Search of human proteins with 58082089

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
         (674 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|58082089 hypothetical protein LOC161394 [Homo sapiens]            1363   0.0  
gi|104526627 triadin [Homo sapiens]                                    91   5e-18
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              86   1e-16
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     83   9e-16
gi|217330641 IWS1 homolog [Homo sapiens]                               82   2e-15
gi|110349719 titin isoform N2-A [Homo sapiens]                         79   1e-14
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   79   1e-14
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   79   1e-14
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   79   1e-14
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    79   1e-14
gi|148746195 trichohyalin [Homo sapiens]                               77   5e-14
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          77   7e-14
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       74   3e-13
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    74   4e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    74   4e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    73   7e-13
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       68   3e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    67   4e-11
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo...    67   7e-11
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    66   9e-11
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    65   2e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    65   3e-10
gi|118722349 RNA binding motif protein 12B [Homo sapiens]              65   3e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    64   3e-10
gi|100816397 MYST histone acetyltransferase (monocytic leukemia)...    64   3e-10
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    64   5e-10
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    64   5e-10
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    64   5e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    64   5e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    63   8e-10

>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
          Length = 674

 Score = 1363 bits (3528), Expect = 0.0
 Identities = 674/674 (100%), Positives = 674/674 (100%)

Query: 1   MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60
           MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE
Sbjct: 1   MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60

Query: 61  EEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFK 120
           EEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFK
Sbjct: 61  EEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFK 120

Query: 121 DLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERN 180
           DLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERN
Sbjct: 121 DLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERN 180

Query: 181 LELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPET 240
           LELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPET
Sbjct: 181 LELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPET 240

Query: 241 PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK 300
           PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK
Sbjct: 241 PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK 300

Query: 301 GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES 360
           GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES
Sbjct: 301 GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES 360

Query: 361 PEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFS 420
           PEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFS
Sbjct: 361 PEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFS 420

Query: 421 KEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQ 480
           KEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQ
Sbjct: 421 KEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQ 480

Query: 481 PLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQF 540
           PLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQF
Sbjct: 481 PLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQF 540

Query: 541 EHLNWDPEEVAEWISQLGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISR 600
           EHLNWDPEEVAEWISQLGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISR
Sbjct: 541 EHLNWDPEEVAEWISQLGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISR 600

Query: 601 HTQELLEIEEPLFKRSISLPYRDIIGLYLEQKGHTGIKSDSLTLSEFVKAAGLQDYAPEI 660
           HTQELLEIEEPLFKRSISLPYRDIIGLYLEQKGHTGIKSDSLTLSEFVKAAGLQDYAPEI
Sbjct: 601 HTQELLEIEEPLFKRSISLPYRDIIGLYLEQKGHTGIKSDSLTLSEFVKAAGLQDYAPEI 660

Query: 661 TAPEENEELPCTEP 674
           TAPEENEELPCTEP
Sbjct: 661 TAPEENEELPCTEP 674


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 131/590 (22%), Positives = 233/590 (39%), Gaps = 79/590 (13%)

Query: 2   AEVPEDYDSGPDED-GELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60
           +E  ED D   D D GE++        +HK     +     K  +K+  +  ++ + +  
Sbjct: 116 SEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVR 175

Query: 61  EEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKS-------ETSR 113
           E++  E +    + ++ K    ++    ++ K     ++E    +EVK        +T+ 
Sbjct: 176 EKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAA 235

Query: 114 EMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTE-----DVFLESAMETDPDP-VPPTET 167
           ++ E  K    P ++  KE       E K          D+F+   ++    P +PP   
Sbjct: 236 KVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLP 295

Query: 168 MSEVSGATVRERNLELLEEE---TEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGES 224
             + S  T     LE  E E    E  V  E+ + + E+   +  ++T  D   ++ G++
Sbjct: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355

Query: 225 LE-----------------ETDLQPPKMTKPETPEETQRESTEKKR--TEPPEQARLEF- 264
            E                 E      K  KP   E+ + +  EKK    EP +  + E  
Sbjct: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHS 415

Query: 265 ------LEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK-GTELPERTKPDFPDHKP 317
                 ++ +  ++ EE G    ++  P   EE   K  E++   E   +T     D +P
Sbjct: 416 VPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP 475

Query: 318 RKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE 377
            K  +E VP  L+E      E E++K  +E + +  + +KP+ P+   K  EK  PQ  +
Sbjct: 476 IKGKEEKVPASLKE-----KEPETKK--DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKK 528

Query: 378 ETGPVLPQEINPQVE-----EKTQT--KPTEKILE------LPDETKPRETHVEFSKEDR 424
           E  P + +++    +     EKT +  KP EK+L+      +    KP+ T     +E  
Sbjct: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHRERE 588

Query: 425 PEPIKS--KYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPL 482
           P  IK+           E  E  + K  +S+K  KE   +  LR  EE + T  E LQ  
Sbjct: 589 PPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLR--EEKVSTRKESLQ-- 644

Query: 483 QKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQP 532
             L NV++       +E    +S+ V +      ++E  E VS   +  P
Sbjct: 645 --LHNVTK-------AEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSP 685



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 66/356 (18%), Positives = 140/356 (39%), Gaps = 33/356 (9%)

Query: 200 QHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE-ETQRESTEKKRTEPPE 258
           + ++ G E  ++ + D P       L + ++   K  K E PE + Q + T K++ +  E
Sbjct: 119 EEDDDGDEDTDKGEIDEPP------LRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKE 172

Query: 259 QARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPR 318
           + R +  EK  +K++ +  +E  E+ + +   + Q+KA   + +E  E+TK +    K  
Sbjct: 173 KVREK--EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSE--EKTKKEVKGGKQE 228

Query: 319 KSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEM------------------MKPES 360
           K   +     ++E++    + + ++  E+  + + E                   +KP  
Sbjct: 229 KV--KQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQ 286

Query: 361 PEEIRKSNEKKNPQPPEETGPVLPQEINPQ--VEEKTQTKPTEKILELPDETKPRETHVE 418
              I      +    P    P L ++   +   E+K  ++  +K  E   +   +ET ++
Sbjct: 287 SPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAID 346

Query: 419 FSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEF 478
             K++  +  ++K        +    K  K   S K +K         + +E    H E 
Sbjct: 347 VEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEP 406

Query: 479 LQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEK 534
            +  +K  +V  +      +E   E    V  K+ V   +E K   + + E + EK
Sbjct: 407 AKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 119/454 (26%), Positives = 188/454 (41%), Gaps = 53/454 (11%)

Query: 12   PDEDGELEPERP--ELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEP 69
            P+ +GE +PE    E P      + AE +   +++     E   E QPE+E+ +     P
Sbjct: 1838 PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVE----TP 1893

Query: 70   DSAKNVQLKPGGTSQEGIAKESKRDVPS----ETEPGIHQEVKSETSREMGEFFKDLEAP 125
            ++   VQ +  G       KE++ +  S    ETE     E +   ++E  E  ++ E  
Sbjct: 1894 EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEG- 1952

Query: 126  MDETHKESDL----EPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNL 181
              +T  ES++    E  EEA+P  +EDV    A+E +       ET      A     ++
Sbjct: 1953 --QTQPESEVIESQEAEEEAQPE-SEDV---EALEVE------VETQEAEGEAQPESEDV 2000

Query: 182  ELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLE-ETDLQPPK--MTKP 238
            E  E E E    EE    Q E  G+E   +++ +   E  GE+ + E D QP    +  P
Sbjct: 2001 EAPEAEGEMQEAEE--EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAP 2058

Query: 239  ETPEETQRESTEKKRTE---PPEQARLEFLEKEPRKSSEEAGLEPPE---ETQP----EV 288
            E  EE Q    E +  E    PE   ++  E E     E  G+E PE   E Q     E 
Sbjct: 2059 EAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118

Query: 289  PEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEET 348
            PE       E +G E PE      P+ +  ++ D        E + E    E+++  EE 
Sbjct: 2119 PETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAE-----GEAQPESEGIEAQEAEEEA 2173

Query: 349  ILEQSEMMKPESPEEIRKSNEK-KNPQPPEETGPVLPQEINPQVEEKTQTKPT-EKILEL 406
              E   +  PE+  E +  +E  + P+   E  P L     P+ EE+ Q +P   +  E 
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEA 2233

Query: 407  PDETKPRETHVEFSKEDRPEPIKSKYSVGNDELE 440
              E +P E+  E   E +  P   + S+G+ + E
Sbjct: 2234 EGEAQP-ESEGETQGEKKGSP---QVSLGDGQSE 2263



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 128/531 (24%), Positives = 205/531 (38%), Gaps = 80/531 (15%)

Query: 5    PEDYD-SGPDEDGELEPERPELPGLHKLYE-----------NAEPDTMAKADSKLPAEIY 52
            PE  D   P+ +GE +PE  ++      +E            AE +   + +S    E  
Sbjct: 1869 PESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETE 1928

Query: 53   QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
             E +PE+E  + +E E ++A+  + +    S+   ++E++ +   E+E     EV+ ET 
Sbjct: 1929 GEDEPESEGAEAQEAE-EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQ 1987

Query: 113  REMGEF---FKDLEAP-----MDETHKESDLEPPE-EAKPNV-----------TEDVFLE 152
               GE     +D+EAP     M E  +E+  E    EA+P             T+    +
Sbjct: 1988 EAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047

Query: 153  SAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQT 212
            +  E+D    P  E  ++ +   V+E   E   E  +    E     Q E  G+E PE  
Sbjct: 2048 AQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAE 2107

Query: 213  KQDFPSEKL------GESLEETD-LQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL 265
             +   +E +      GE+  E++ ++ P+      PE    E+ + +    PE   +E  
Sbjct: 2108 GEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQ 2167

Query: 266  EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENV 325
            E E     E  G+E PE      PE    +A E +G   PE    + P+     + +E  
Sbjct: 2168 EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPE-----AEEEAQ 2222

Query: 326  PEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE------EIRKSNEKKNPQPPEE- 378
            PEP     +E PE E     E     Q E  K  SP+      +  +++E  +P P +  
Sbjct: 2223 PEP---EGVETPEAEGEAQPESEGETQGE--KKGSPQVSLGDGQSEEASESSSPVPEDRP 2277

Query: 379  TGPVLPQEINPQVEEKTQTKPT-----------------EKIL---ELPDETKPRETHVE 418
            T P  P    P     +QT P+                 + +L     PD       H E
Sbjct: 2278 TPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAE 2337

Query: 419  FSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESE 469
              K  R  P  S        L  R P++G     D   +E  ALGSL  +E
Sbjct: 2338 -RKATRMYPESSTSEQEEAPLGSRTPEQGASEGYD--LQEDQALGSLAPTE 2385



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 85/388 (21%), Positives = 155/388 (39%), Gaps = 37/388 (9%)

Query: 65   KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
            K GE    +  ++ PG T  +  +  + +       PG+ Q    +   + GE  + L  
Sbjct: 1696 KRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED-GEGSQRLNR 1754

Query: 125  PMDETHKESD---LEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNL 181
              D    E++   +    E K + +E        E + +    +E        +  E NL
Sbjct: 1755 DKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNL 1814

Query: 182  E---LLEEETEPG---------VPEESLRVQHEETGLEPPEQT----KQDFPSEKLGESL 225
            +       + +PG          PE     Q E  G+E PE      + +  ++   E +
Sbjct: 1815 QGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV 1874

Query: 226  EETDLQ---PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPE 282
            E  + +    P+    ETPE       E +  E PE  +    E +P   S EA LE   
Sbjct: 1875 EAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEK----EAQPETESVEA-LETEG 1929

Query: 283  ETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESR 342
            E +PE  E  + +  EE   E   +T+P+    + +++ +E  PE  E+++    E E++
Sbjct: 1930 EDEPE-SEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPES-EDVEALEVEVETQ 1987

Query: 343  KTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP-EETGPVLPQEINPQVEEKTQ----- 396
            +   E   E  ++  PE+  E++++ E+  P+    E  P    E   +VE +TQ     
Sbjct: 1988 EAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047

Query: 397  TKPTEKILELPD-ETKPRETHVEFSKED 423
             +P    +E P+ E + +E   E  + +
Sbjct: 2048 AQPESDGVEAPEAEEEAQEAEGEVQEAE 2075



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 95/447 (21%), Positives = 155/447 (34%), Gaps = 43/447 (9%)

Query: 132  ESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSG-ATVRERNLELLEEETEP 190
            E  L P     P V E    E +   + D  P    + E  G A  +ER  +    ET  
Sbjct: 1727 EGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPK---LGEAEGDAMAQEREGKTHNSETSA 1783

Query: 191  GVPEESLRVQHEETGLEPPEQTKQDFPSEK---LGESLEETDLQPPKMTKPE---TPEET 244
            G   E    + E  G+    +T       +    GE+    D  P +    E    PE  
Sbjct: 1784 G--SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAE 1841

Query: 245  QRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTEL 304
                 E +  E PE       E + +++  EA  E  +   PE   E Q ++ + +  E 
Sbjct: 1842 GEAQPESEGVEAPEA------EGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895

Query: 305  -----PERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTN--EETILEQSEMMK 357
                 PE    + P+ +     +    E LE    + PE E  +    EE   E     +
Sbjct: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955

Query: 358  PESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELP---------- 407
            PES E I     ++  QP  E    L  E+  Q E + + +P  + +E P          
Sbjct: 1956 PES-EVIESQEAEEEAQPESEDVEALEVEVETQ-EAEGEAQPESEDVEAPEAEGEMQEAE 2013

Query: 408  DETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRE 467
            +E +P    VE   +   E  +             +P+   +   +   +   A G ++E
Sbjct: 2014 EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073

Query: 468  SEESIGTHYEFL--QPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERV- 524
            +E       E +  Q  +       E   +  +E + + +E +   E    +Q   E + 
Sbjct: 2074 AEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIE 2133

Query: 525  --SEDDETQPE-KGTELQFEHLNWDPE 548
                + E QPE +G E Q       PE
Sbjct: 2134 APEAEGEAQPESEGVEAQDAEGEAQPE 2160



 Score = 36.6 bits (83), Expect = 0.078
 Identities = 48/217 (22%), Positives = 82/217 (37%), Gaps = 19/217 (8%)

Query: 53   QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQE--VKSE 110
            +E +  +  E   E        ++    GT  EG+ +E+ +   ++TE G+ +E     E
Sbjct: 1281 EEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE 1340

Query: 111  TSREMGEFFKDLEAPMDETHKES---------DLEPPEEAKPNVTEDVFLESAMETDPDP 161
            T    GE  ++ EA ++E  +            LE  +E      +   LE  ++ +  P
Sbjct: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP 1400

Query: 162  VPPT---ETMSEVS---GATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQD 215
               +   + +SE S   G   +E +    EE        E    +  E   EPP    + 
Sbjct: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET 1460

Query: 216  FP--SEKLGESLEETDLQPPKMTKPETPEETQRESTE 250
             P  SE+   S  E  L+ P        E TQ + T+
Sbjct: 1461 DPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQ 1497



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 65/249 (26%), Positives = 98/249 (39%), Gaps = 37/249 (14%)

Query: 300  KGTELPERTKPDFPDHKPRKSTDENVPEPLE-EIKLEFPEEESRK-----TNEETILEQS 353
            +GTELP +T    PD +  +S     P  LE + +  FP   + +     TNE+     S
Sbjct: 1226 QGTELPLKTSNQRPDSRTYES-----PGDLENQQQCCFPTFLNARACACATNEDEAERDS 1280

Query: 354  EMMKPESPEEIRKSNEKKNPQPPEET-----GPVLPQEINPQVEEKTQTKPTEKILELPD 408
            E  +  S  E    N  +     EET     G  L +E     E KT+    E+ ++L +
Sbjct: 1281 EEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQL-E 1339

Query: 409  ETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRES 468
            ETK  ET  E  +E+              +LE  E   G     +  ++E   L  ++E 
Sbjct: 1340 ETK--ETEGEGQQEEEA------------QLEEIEETGG-----EGLQEEGVQLEEVKEG 1380

Query: 469  EESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDD 528
             E  G   E L+   K   + EE S      S+    +    +E   + +E   R S   
Sbjct: 1381 PEG-GLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASA 1439

Query: 529  ETQPEKGTE 537
            E  P +GTE
Sbjct: 1440 EPCPAEGTE 1448


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 82.8 bits (203), Expect = 9e-16
 Identities = 101/441 (22%), Positives = 180/441 (40%), Gaps = 45/441 (10%)

Query: 20   PERPELPGLHKLYENAEPDTMAKADSKLPAEIY--QEPQPETEEEDFKEGEPDSAKNVQL 77
            PE+ + P   +    AE  +  K ++K PAE+   ++ +  T+EE     +  S +  + 
Sbjct: 601  PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660

Query: 78   KPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEP 137
            K    ++  +  E+K   P + +  +  E KS          +  ++P+ E  K      
Sbjct: 661  KSPEKAKSPVKAEAKS--PEKAKSPVKAEAKSP---------EKAKSPVKEEAKS----- 704

Query: 138  PEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESL 197
            PE+AK  V E+     + E    PV       E + + V+E      +   +   PE++ 
Sbjct: 705  PEKAKSPVKEEA---KSPEKAKSPVKEEAKTPEKAKSPVKEE----AKSPEKAKSPEKAK 757

Query: 198  RVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
             +  +    + P + +   P++K  E  +    +  K   PE  +   +E  +    E P
Sbjct: 758  TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK--SPEKAKSPLKEDAKAPEKEIP 815

Query: 258  EQARLEFLEKEPRKSSEEAGLEPP----EETQPEVPEEMQRKATEEKGTELPERTKPDFP 313
            ++  ++   KE  K  E    EPP    EE  P  P     K  E+K ++  E  K + P
Sbjct: 816  KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATP-----KTEEKKDSKKEEAPKKEAP 870

Query: 314  DHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNE---- 369
              K  +  +  V +P +E K+E  +EE+    +    E+    K E  E+ +   +    
Sbjct: 871  KPKVEEKKEPAVEKP-KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929

Query: 370  KKNPQPPEETGPVLPQEINPQVEEKTQTK--PTEKILELP-DETKPRETHVEFSKE-DRP 425
            KK P   +   P  P E      EK  TK    +K  E P  E K +E     SKE  +P
Sbjct: 930  KKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP 989

Query: 426  EPIKSKYSVGNDELEHREPKR 446
            +  K++ S   D+ + + P++
Sbjct: 990  KAEKAEKSSSTDQKDSKPPEK 1010



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 127/562 (22%), Positives = 214/562 (38%), Gaps = 81/562 (14%)

Query: 36   EPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDV 95
            E +  AK +     E  +E + E  EE+ K    + A + + +     +E     ++   
Sbjct: 473  EEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS 532

Query: 96   PSETEPGIHQEVKS-----ETSREMGEFFKDLEAP-MDETHKESDLEPPEEAKPNVTEDV 149
            P + E     EVKS       ++E  +   + ++P  +E    ++++ PE+AK    E+ 
Sbjct: 533  PEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592

Query: 150  FLES---AMETDPDPV-----PPTETMSEV-----SGATVRERNLELLEEETEPGVPEES 196
               +   + E    PV      P E  S V     S A V+         + E   PE++
Sbjct: 593  KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652

Query: 197  LRVQHEETGLEPPEQTKQDFPSE----KLGESLEETDLQPPKMTKPETPEET----QRES 248
               + EE   + PE+ K    +E    +  +S  + + + P+  K    EE     + +S
Sbjct: 653  KSPEKEEA--KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS 710

Query: 249  TEKKRTEPPEQARLEFLE--KEPRKSS---EEAGLEPPEETQPEVPEEMQRKATEEKGTE 303
              K+  + PE+A+    E  K P K+    +E    P +   PE  + +  K+ E K   
Sbjct: 711  PVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA 770

Query: 304  LPERTKP--DFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESP 361
              E   P   FP+ K +    E V  P    K + P +E  K  E+ I ++ E+  P   
Sbjct: 771  KEEARSPADKFPE-KAKSPVKEEVKSP---EKAKSPLKEDAKAPEKEIPKKEEVKSPVKE 826

Query: 362  EEIRKSNEKKNPQPP----EETGPVLPQ------EINPQVEEKTQTKPTEKILELPDETK 411
            EE  K  E K  +PP    EE  P  P+          +  +K   KP  +  + P   K
Sbjct: 827  EE--KPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884

Query: 412  PRETHVEFSKEDR------PEPIK---SKYSVGND-------ELEHREPKRGKLSLSDKF 455
            P+E+ VE  KE+       P P K   +K  V  D       E+  +EP   K     K 
Sbjct: 885  PKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKP 944

Query: 456  RKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVD 515
             ++  A    ++++E      E     +      ++    +PS+ + E            
Sbjct: 945  AEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAE------------ 992

Query: 516  LSQELKERVSEDDETQPEKGTE 537
               E      + D   PEK TE
Sbjct: 993  -KAEKSSSTDQKDSKPPEKATE 1013



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 104/468 (22%), Positives = 186/468 (39%), Gaps = 39/468 (8%)

Query: 6   EDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFK 65
           E+  S P E+     +  + P   +    AE  +  K ++K PAE+     PE  +   K
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV---KSPEKAKSPAK 555

Query: 66  EG--EPDSAKNVQLKPGGT-----SQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEF 118
           E    P  AK+ + +   +     S E     +K +  S  E    ++ KS    E    
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615

Query: 119 FKDLEAPMDETHKESDLEPPEEAK-PNVTEDVFLESAMETDPDPVPPTETMSEVSGATVR 177
            +      +E    ++++ PE+AK P   E    E A   + +     E       A  +
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAK 675

Query: 178 ERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTK 237
                    + E   PE++     EE   + PE+ K     E       ++ ++    T 
Sbjct: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733

Query: 238 PETPEETQRESTEKKRTEPPEQAR-LEFLEKEPRKSSEEAGLEP----PEETQPEVPEEM 292
            +     + E+   ++ + PE+A+ L+    E +  ++E    P    PE+ +  V EE+
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793

Query: 293 QRKATEEKGTELPERTKP---DFPDHKPRKSTDENVPEPLEEIKLEFP----EEESR--- 342
             K+ E+  + L E  K    + P  +  KS  +   +P +E+K++ P    EEE     
Sbjct: 794 --KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP-QEVKVKEPPKKAEEEKAPAT 850

Query: 343 -KTNEETILEQSEMMKPESPEEIRKSNEKKNP---QPPEETGPVLPQEINPQVEEKTQTK 398
            KT E+   ++ E  K E+P+   K  EKK P   +P E       +E   + +  T  K
Sbjct: 851 PKTEEKKDSKKEEAPKKEAPKP--KVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK 908

Query: 399 PTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKR 446
                +E+ ++ KP+E      KE  P+  K+K      E +   P++
Sbjct: 909 EAPAKVEVKEDAKPKEKTEVAKKE--PDDAKAKEPSKPAEKKEAAPEK 954



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 79/317 (24%), Positives = 132/317 (41%), Gaps = 39/317 (12%)

Query: 2    AEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPD--TMAKADSKLPAEIYQEPQPET 59
            A+ PE   S   E+ +  PE+ + P   K  +   P+  T AK +++ PA+ + E     
Sbjct: 730  AKTPEKAKSPVKEEAK-SPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSP 788

Query: 60   EEEDFKEGEPDSAKNVQLKPGGTSQEGIAK--ESKRDVPSETEPGIHQEVKSETSREMGE 117
             +E+ K   P+ AK+   +     ++ I K  E K  V  E +P   QEVK +   +  E
Sbjct: 789  VKEEVKS--PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKP---QEVKVKEPPKKAE 843

Query: 118  FFKDLEAPMDETHKESDLE--PPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGAT 175
              K    P  E  K+S  E  P +EA                   P P  E   E +   
Sbjct: 844  EEKAPATPKTEEKKDSKKEEAPKKEA-------------------PKPKVEEKKEPAVEK 884

Query: 176  VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDF-PSEKLGESLEETDLQPPK 234
             +E  +E  +EE E     +  +V   E       + K+D  P EK   + +E D    K
Sbjct: 885  PKESKVEAKKEEAE-----DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD--DAK 937

Query: 235  MTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQR 294
              +P  P E +  + EKK T+  +  + E   K   K+ E+      E ++P+  +  + 
Sbjct: 938  AKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKS 997

Query: 295  KATEEKGTELPERTKPD 311
             +T++K ++ PE+   D
Sbjct: 998  SSTDQKDSKPPEKATED 1014



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 104/492 (21%), Positives = 190/492 (38%), Gaps = 49/492 (9%)

Query: 87  IAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVT 146
           + ++S+++     E     +V  E + E  +  K+ E   +E  +E + E  EE     T
Sbjct: 446 VVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE----T 501

Query: 147 EDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGL 206
           +    E A   + +   P +  ++ S A  +    E  +   E   PE++     EE   
Sbjct: 502 KSPPAEEAASPEKEAKSPVKEEAK-SPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560

Query: 207 EPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLE 266
            P  ++ +   ++   E       + P   + ++P E +  S EK ++   E+A+     
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK--SPEKAKSPVKEEAKSPAEA 618

Query: 267 KEPRK--SSEEAGLEPPEETQPEVPEEM----QRKATEEKGTELPERTKPDFPDH--KPR 318
           K P K  +   A ++ PE+ +    EE     + K+ E++  + PE+ K         P 
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678

Query: 319 KSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEE 378
           K+      E     K + P +E  K+ E+      E  K  SPE+ +   +++   P + 
Sbjct: 679 KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK--SPEKAKSPVKEEAKTPEKA 736

Query: 379 TGPVLPQEINPQ---------------VEEKTQTK-----PTEKILE-----LPDETKPR 413
             PV  +  +P+                E KT  K     P +K  E     + +E K  
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796

Query: 414 ETHVEFSKEDRPEP---IKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEE 470
           E      KED   P   I  K  V +   E  +P+  K+    K  +E  A  + +  E+
Sbjct: 797 EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856

Query: 471 SIGTHYEFLQPLQKLLNVSE--ECSYSDPSESQTEL--SEFVHEKEVVDLSQELKERVSE 526
                 E  +       V E  E +   P ES+ E    E   +K+V    +E   +V  
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV 916

Query: 527 DDETQPEKGTEL 538
            ++ +P++ TE+
Sbjct: 917 KEDAKPKEKTEV 928



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 83/367 (22%), Positives = 145/367 (39%), Gaps = 52/367 (14%)

Query: 190 PGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQREST 249
           P +P  S  ++     ++  E+ K    SEK    +EE   +     +    EE + +  
Sbjct: 427 PKIPSVSTHIK-----VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEE 481

Query: 250 EKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEE----MQRKATEEKGTELP 305
           E K  E  E+   E  E+E +    E    P +E +  V EE     + K+ E++  + P
Sbjct: 482 EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSP 541

Query: 306 ERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIR 365
              K       P K   ++ PE       + PE+E  K+  E  ++  E  K  + EE +
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPE------AKSPEKEEAKSPAE--VKSPEKAKSPAKEEAK 593

Query: 366 KSNEKKNPQ------------PPEETGPVLPQEINP-QVEEKTQTK-PTEKILELPDETK 411
              E K+P+            P E   PV  +  +P +V+   + K PT++  + P++ K
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAK 653

Query: 412 PRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEES 471
             E      KE+   P K+K  V   + E + P++ K  +  + +    A   ++E  +S
Sbjct: 654 SPE------KEEAKSPEKAKSPV---KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS 704

Query: 472 IGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQ 531
                    P +    V EE    + ++S  +      EK    + +E K   S +    
Sbjct: 705 ---------PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAK---SPEKAKS 752

Query: 532 PEKGTEL 538
           PEK   L
Sbjct: 753 PEKAKTL 759


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 115/549 (20%), Positives = 217/549 (39%), Gaps = 73/549 (13%)

Query: 47  LPAEIYQEPQPE----TEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPG 102
           + +E Y   Q +    T  +D ++   D   +V  +  G+    + + S+ +  S+ E G
Sbjct: 1   MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENET-SDREDG 59

Query: 103 I---HQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDP 159
           +   H    SE    +     D E+      K+SD E  E A+P          A +++ 
Sbjct: 60  LPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEP---------PASDSEN 110

Query: 160 DPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSE 219
           + V    + SE    +   R L   + E E  +   +   ++E+ G  P   ++ +   +
Sbjct: 111 EDVNQHGSDSE----SEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQK 166

Query: 220 KLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKS-SEEAGL 278
                 E  D   P+++  E+ E  + ++++ +  EPP          +PR S SE   L
Sbjct: 167 SPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP----------KPRMSDSESEEL 216

Query: 279 EPPEETQPEVPEEMQRKATEEKGTELP-----ERTKPDFPDHKPRKSTDENVPEPLEEIK 333
             P+ +  E  E  + +A++ +  ELP     +    D P H+   S +E +P+P    +
Sbjct: 217 PKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKP----R 272

Query: 334 LEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEE 393
           +   E E    N+ +  E  E+ KP   +       +K P    ET      +  P+ ++
Sbjct: 273 ISDSESEDPPRNQASDSENEELPKPRVSDS-ESEGPQKGPASDSETEDASRHKQKPESDD 331

Query: 394 KTQTKPTEKILELPDETKPRETHVE---FSKEDRPEPIKSKYSVGNDELEHREPKRGKLS 450
            +  +   +  E+ +++   ++H++   F   D  E    K  + +DE    + K G+  
Sbjct: 332 DSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE----DEKEGE-- 385

Query: 451 LSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTEL----SE 506
             +K  K   A+ S  E EE           +    + S+  + SD S  + +     SE
Sbjct: 386 -EEKVAKRKAAVLSDSEDEEKASAK---KSRVVSDADDSDSDAVSDKSGKREKTIASDSE 441

Query: 507 FVHEKEVVDLSQELKERVSEDDETQPEK-----------GTELQFEHLNWDPEEVAEWIS 555
               KE+ D   E K+    D E+  E+           G E + E   ++ E++ E   
Sbjct: 442 EEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE--- 498

Query: 556 QLGFPQYKE 564
           + G  Q KE
Sbjct: 499 EKGETQVKE 507



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 108/600 (18%), Positives = 215/600 (35%), Gaps = 30/600 (5%)

Query: 33  ENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESK 92
           EN EP  +  +DS+   E++++   ++E E+  E     ++N  +   G+  E    E  
Sbjct: 70  ENDEPLNLNASDSE-SEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSES---EET 125

Query: 93  RDVP---SETEPGIHQEVKSETSREMGEF-FKDLEAPMDETHKESDLEPPEEAKPNVTED 148
           R +P   SE E  ++       + ++G+    D E    +    SD E  +  KP +++ 
Sbjct: 126 RKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDS 185

Query: 149 VFLESAMETDPDPV---PPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETG 205
              E       D     PP   MS+     + +  +   E E  P    ++   ++EE  
Sbjct: 186 ESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPR--HQASDSENEELP 243

Query: 206 LEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL 265
                 ++ + P        E  +L  P+++  E+ +  + ++++ +  E P+    +  
Sbjct: 244 KPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSE 303

Query: 266 EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPD-HKPRKSTDEN 324
            + P+K               + PE       E KG +   +      D H  RK    +
Sbjct: 304 SEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSS 363

Query: 325 VPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKN---PQPPEETGP 381
             E  E  K +   +E  K  EE  + + +       E+  K++ KK+       +    
Sbjct: 364 DSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSD 423

Query: 382 VLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEP---IKSKYSVGNDE 438
            +  +   + +        E   EL D+    +       E   E    I   +    DE
Sbjct: 424 AVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDE 483

Query: 439 LEHREPKRGKLSLSDKFRKEYYALGSLRESEESI--GTHYEFLQPLQKLLNVSEECSYSD 496
            E       +  L ++  +         +S+++I  G H +FL   + +L    + S S 
Sbjct: 484 EEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMML--QRKKSMSG 541

Query: 497 PSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEWISQ 556
                 +   F+ + + V  +  +K   + +++ Q     +   + L   P  V     Q
Sbjct: 542 KRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQ 601

Query: 557 LGFPQYKECFITNFISGRKLIHVNCSNLPQMGITNFEDMKAISRHTQELLEIEEPLFKRS 616
                 KE FI + +     I    S LP   +   +  + + +  QEL  + +   K S
Sbjct: 602 ----DLKETFIDSGV--MSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHS 655


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 120/521 (23%), Positives = 198/521 (38%), Gaps = 56/521 (10%)

Query: 50    EIYQEPQPETEEEDFKEGEPDSAKN-VQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVK 108
             EI +E +    EE F+EGE    +  ++L+     +E   ++  R +       +    K
Sbjct: 10376 EIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEK 10435

Query: 109   SETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDP------- 161
              +   +  E  + +  P     K    + P    P V + + +E  +    +P       
Sbjct: 10436 PKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKV 10495

Query: 162   ---VPPTETMSE----VSGATVRERNLELLEEETEPGVPEESLRV----QHEETGLEPPE 210
                +PP E + E    V  A   E     + E  +  VPE+ + V    + E    + PE
Sbjct: 10496 PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPE 10555

Query: 211   QTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKK-RTEPPEQARLEFLE--K 267
               K   P +K+ E++      PP    PE PE  +    EKK    PP++  +  ++  +
Sbjct: 10556 VPKAAVPEKKVPEAIPPKPESPP----PEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPE 10611

Query: 268   EPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPE 327
              P++   E  +  P   +PEVP     K  E     +PE+  P+    KP     E   E
Sbjct: 10612 APKEVVPEKKVPVPPPKKPEVP---PTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEE 10668

Query: 328   PLEEIKLEFP------EEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGP 381
             P EE+ LE P      E E     + T+  +  + + ++P  + K  E    + PE    
Sbjct: 10669 P-EEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKE 10727

Query: 382   VLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEH 441
             V+P++  P V  K    P  K+ E+P E  P E  V   K+    P K         LE 
Sbjct: 10728 VVPEKKVPLVVPKKPEAPPAKVPEVPKEVVP-EKKVAVPKKPEVPPAKVPEVPKKPVLEE 10786

Query: 442   RE----PKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDP 497
             +     P+R +    + +           E  E I    E     +K + V+EE     P
Sbjct: 10787 KPAVPVPERAESPPPEVY-----------EEPEEIAPEEEIAPEEEKPVPVAEEEEPEVP 10835

Query: 498   SES-QTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTE 537
               +   E  + + EK+V  +    K       E +PEK  E
Sbjct: 10836 PPAVPEEPKKIIPEKKVPVIK---KPEAPPPKEPEPEKVIE 10873



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 116/474 (24%), Positives = 182/474 (38%), Gaps = 65/474 (13%)

Query: 12    PDEDGELEPER-PELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPD 70
             P +  E+ P + PE+P    + E   P+ +       P E+ + P+    E+      P 
Sbjct: 10542 PPKKPEVPPTKVPEVPKA-AVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPK 10600

Query: 71    SAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA--PMDE 128
               +   +K     +E +  E K  VP   +P +      E  +      K  EA  P  E
Sbjct: 10601 KPEVTPVKVPEAPKE-VVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPE 10659

Query: 129   THKESDLEPPEEAKPNVTEDVFLESAMETDPDP-----VPPTETMSEVSGATVRERNLEL 183
             +      E PEE      E+   E   E +P       VPP + + E     V  +  EL
Sbjct: 10660 SPPPEVFEEPEEV---ALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPEL 10716

Query: 184   ----LEEETEPGVPEESLRV----QHEETGLEPPEQTKQDFPSEKLG---------ESLE 226
                 + E  +  VPE+ + +    + E    + PE  K+  P +K+            + 
Sbjct: 10717 PPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVP 10776

Query: 227   ETDLQPPKMTKPETPEETQRESTEKKRTEPPEQ-ARLEFLEKEPRKSSEEAGLEPPEETQ 285
             E   +P    KP  P   + ES   +  E PE+ A  E +  E  K    A  E PE   
Sbjct: 10777 EVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPP 10836

Query: 286   PEVPEEMQRKATEEKGTELPERTKPDFPDHK--------------------PRKSTDENV 325
             P VPEE ++   E+K   +P   KP+ P  K                    P     E+V
Sbjct: 10837 PAVPEEPKKIIPEKK---VPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDV 10893

Query: 326   PEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEET--GPVL 383
              E + ++K    ++   K      +E + +  P   +++RK   ++ P+P EE     VL
Sbjct: 10894 KEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVL 10953

Query: 384   ---PQEINPQVEEKTQTKPTEKILELPDETKPRETHVE---FSKEDR--PEPIK 429
                P+E  P+VE K   K  +  +  P   KP E  VE    +K +R  PEP K
Sbjct: 10954 RKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVE-EVEVPTVTKRERKIPEPTK 11006



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 109/460 (23%), Positives = 171/460 (37%), Gaps = 73/460 (15%)

Query: 14    EDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAK 73
             E  +  P+ PE+    K+    +P T      + PA++ + P+    EE  +  E     
Sbjct: 10434 EKPKAPPKGPEIS--EKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVP 10491

Query: 74    NVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKES 133
               ++ P     + +  E K  VP   +P        E  +E+    K +  P  +  +  
Sbjct: 10492 PTKV-PEVLPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPE-KKVPVPPPKKPEVP 10549

Query: 134   DLEPPEEAKPNVTEDVFLESAM---ETDPDPVP--PTETMSEVSGATVRERNLEL----L 184
               + PE  K  V E    E+     E+ P  VP  P E + E        +  E+    +
Sbjct: 10550 PTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKV 10609

Query: 185   EEETEPGVPEESLRV----QHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKP-- 238
              E  +  VPE+ + V    + E    + PE  K   P +K+ E++      PPK   P  
Sbjct: 10610 PEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAI------PPKPESPPP 10663

Query: 239   ---ETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE----E 291
                E PEE   E    +  E PE A    +   P+K   E         +PE+P     E
Sbjct: 10664 EVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPE 10723

Query: 292   MQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPE----------------------PL 329
             + ++   EK   L    KP+ P  K  +   E VPE                      P+
Sbjct: 10724 VPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPV 10783

Query: 330   EEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEK-------KNPQPPEETGPV 382
              E K   P  E  ++    + E+ E + PE  EEI    EK       + P+ P    P 
Sbjct: 10784 LEEKPAVPVPERAESPPPEVYEEPEEIAPE--EEIAPEEEKPVPVAEEEEPEVPPPAVPE 10841

Query: 383   LPQEINPQVEEKTQTKP---------TEKILELPDETKPR 413
              P++I P+ +     KP          EK++E P + KPR
Sbjct: 10842 EPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKP-KLKPR 10880



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 108/426 (25%), Positives = 172/426 (40%), Gaps = 56/426 (13%)

Query: 17    ELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGE-PDSAKNV 75
             E+ PE   LP         E + + + +  LP E  +E  PE EE   +E E P   + V
Sbjct: 10112 EIVPEEEVLP--------EEEEVLPEEEEVLPEE--EEVLPEEEEIPPEEEEVPPEEEYV 10161

Query: 76    QLKPGGTSQEGIAKESKRDVPSETE-PGIHQEVKSET----SREMGEFFKDLEAPMDETH 130
               +     +E +  E K  VP     P I ++V  +      +E     K  E P     
Sbjct: 10162 PEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEE 10221

Query: 131   KESDLEPPEEAKP-NVTEDVFLESAMETD-PDPVPPTETMSEVSGATVRERNLELLEEET 188
             K   L   EE  P  VTE+   E   E + P+  P  E + EV+   V E   + + E  
Sbjct: 10222 KRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAP 10281

Query: 189   EPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRES 248
              P VP+   +V+       PP +  +  P EK+   +++ +  P K+  PE P++   + 
Sbjct: 10282 TP-VPK---KVE------APPAKVSKKIPEEKVPVPVQKKEAPPAKV--PEVPKKVPEKK 10329

Query: 249   T--EKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPE 306
                 KK   PP + R    EK      +E            V E ++ +  E +  E+PE
Sbjct: 10330 VLVPKKEAVPPAKGRTVLEEKVSVAFRQEV----------VVKERLELEVVEAEVEEIPE 10379

Query: 307   RTKPDFPDHKPRKSTDENVPEPLEE-IKLE--FPEEESRKTNEETILEQSEMMKPESPEE 363
               +     H+  +  +E     +EE IKLE    EEE R      ++E  E  + E  E+
Sbjct: 10380 EEE----FHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEK 10435

Query: 364   IRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKED 423
                   K  P+ PE +  ++P +  P  +   + +P  K+ E+P +    E  V   +E 
Sbjct: 10436 -----PKAPPKGPEISEKIIPPK-KPPTKVVPRKEPPAKVPEVPKKIVVEE-KVRVPEEP 10488

Query: 424   RPEPIK 429
             R  P K
Sbjct: 10489 RVPPTK 10494



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 113/458 (24%), Positives = 179/458 (39%), Gaps = 55/458 (12%)

Query: 4     VPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEED 63
             +PE+ +  P+E+ E+ PE   +P   +     E     K    +PA     P PE +++ 
Sbjct: 10141 LPEEEEIPPEEE-EVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPA-----PVPEIKKK- 10193

Query: 64    FKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
               E +    K  +  P    +     E KR +  + E  +  EV  E   E      + E
Sbjct: 10194 VTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEP---ISEEE 10250

Query: 124   APMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPP--TETMSEVSGATVRER-N 180
              P +    E   E  E A P V E   ++ A+   P PVP       ++VS     E+  
Sbjct: 10251 IPEEPPSIE---EVEEVAPPRVPE--VIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVP 10305

Query: 181   LELLEEETEPG--------VPEESLRVQHEETGLEPP--------EQTKQDFPSEKLGES 224
             + + ++E  P         VPE+ + V  +E    PP        E+    F  E + + 
Sbjct: 10306 VPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEA--VPPAKGRTVLEEKVSVAFRQEVVVK- 10362

Query: 225   LEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPP--- 281
              E  +L+  +    E PEE +    E+   E       EF++ E  +  EE  +E     
Sbjct: 10363 -ERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRV 10421

Query: 282   -EETQPEVPEEMQRKATEEKGTELPER-TKPDFPDHK--PRKSTDENVPEPLEEIKLEFP 337
              E  + E  E  ++     KG E+ E+   P  P  K  PRK     VPE  ++I +   
Sbjct: 10422 IEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVV--- 10478

Query: 338   EEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQP----PEETGPVLPQEINPQVEE 393
              EE  +  EE  +  +++ +   P+E+    EKK P P    PE   P +P+     V E
Sbjct: 10479 -EEKVRVPEEPRVPPTKVPEVLPPKEV--VPEKKVPVPPAKKPEAPPPKVPEAPKEVVPE 10535

Query: 394   KTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSK 431
             K    P  K  E+P    P        ++  PE I  K
Sbjct: 10536 KKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPK 10573



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 111/454 (24%), Positives = 173/454 (38%), Gaps = 69/454 (15%)

Query: 32    YENAEPDTMAKADSKLPAEIYQ--EPQPETEEEDFKEGE--------PDSAKNVQLKPGG 81
             YE  E     + +   P E Y   E   E E E ++E E        P   K V  +P  
Sbjct: 9745  YEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVP 9804

Query: 82    TSQEGI-AKESKRDVPSETEP-GIHQEVKSETSREMGE----FFKDLEAPMDETHKESDL 135
             T  +   AK  K+ VP E  P  I +++K    +   E    F + +   + +  KE   
Sbjct: 9805  TKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVT 9864

Query: 136   EPP------------EEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLEL 183
             EP             EE  P   ++V     +   P  + P E   E    T  E   E 
Sbjct: 9865  EPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVE---EY 9921

Query: 184   LEEETEPGVPEESLRVQHEET----GLEPPEQTKQDFPSEKLGESLEETDLQPPKMTK-- 237
             L EE E  + EE   +  EE      ++ PE  ++  P EK    + +    PP      
Sbjct: 9922  LVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEV 9981

Query: 238   PETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKAT 297
             P+ PEE       KK   PP  A++  + K+P           PEE  P VP   + +A 
Sbjct: 9982  PKKPEEKVPVLIPKKEKPPP--AKVPEVPKKP----------VPEEKVP-VPVPKKVEAP 10028

Query: 298   EEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMK 357
               K  E+P++  P+     P     E  P  + E+  +   EE + T    + ++ E   
Sbjct: 10029 PAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPT---PVPKKVEAPP 10085

Query: 358   PESPEEIRKSNEKKNPQP-----PEETGPVLPQEINPQVE---EKTQTKPTEKILELPDE 409
             P+ P       +K+ P P     P+E   +  +EI P+ E   E+ +  P E+ + LP+E
Sbjct: 10086 PKVP-------KKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEV-LPEE 10137

Query: 410   TKPRETHVEFSKEDRPEPIKSKYSVGNDELEHRE 443
              +      E   E+   P + +Y    +E    E
Sbjct: 10138 EEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEE 10171



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 108/430 (25%), Positives = 168/430 (39%), Gaps = 66/430 (15%)

Query: 12    PDEDGELEPER-PELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKE--GE 68
             P +  E+ P + PE+P +  + E   P+ +       P E+++EP+    EE   E   E
Sbjct: 10626 PPKKPEVPPTKVPEVPKV-AVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEE 10684

Query: 69    PDSAKNVQL-----KPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
             P+ A   Q+     KP    +       K ++P    P + +EV  E    +    K  E
Sbjct: 10685 PEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPL-VVPKKPE 10743

Query: 124   AP---MDETHKE------------SDLEP---PEEAKPNVTEDVFLESAMETDPDPVP-- 163
             AP   + E  KE             ++ P   PE  K  V E+       E    P P  
Sbjct: 10744 APPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEV 10803

Query: 164   ---PTETMSEVSGATVRERNLELLEEETE----PGVPEESLRVQHEETGLEPPEQTKQDF 216
                P E   E   A   E+ + + EEE      P VPEE  ++  E+   + P   K + 
Sbjct: 10804 YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEK---KVPVIKKPEA 10860

Query: 217   PSEKLGES---LEETDLQP-PKMTKPETPEETQRESTEKKRTEP----PEQARL-EFLEK 267
             P  K  E    +E+  L+P P    P  P+E  +E   + +  P    PE+ ++ E +E 
Sbjct: 10861 PPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVEL 10920

Query: 268   EPRK--SSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENV 325
              P K    E+   +   E +PE  EE+  K+   K    PE  +P     K  K     V
Sbjct: 10921 TPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKR---PEEEEPKVEPKKLEKVKKPAV 10977

Query: 326   PE-----PLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETG 380
             PE     P+EE+++    +  RK  E T +       PE    I     +  P+P  E  
Sbjct: 10978 PEPPPPKPVEEVEVPTVTKRERKIPEPTKV-------PEIKPAIPLPAPEPKPKPEAEVK 11030

Query: 381   PVLPQEINPQ 390
              + P  + P+
Sbjct: 11031 TIKPPPVEPE 11040



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 135/640 (21%), Positives = 230/640 (35%), Gaps = 139/640 (21%)

Query: 17   ELEPERPELPGLHK--LYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF-----KEGEP 69
            ++EP  P++P + K  + E  +P  + K +   P ++ + P+    EE       K+ E 
Sbjct: 9308 KVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEA 9367

Query: 70   DSAKNVQLKPGGTSQEGIA-----KES---------KRDVPSETEPGIHQEVKSETSREM 115
              AK  +++ G  ++E I      +ES         K+ VP E +P   +E +     ++
Sbjct: 9368 PPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKV 9427

Query: 116  GEFFKD------LEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMS 169
                K       +  P+    K          K  V E  F+     +   P     T  
Sbjct: 9428 PALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRH 9487

Query: 170  EVS------------GATV---------RERNLELLE----EETEPGVPEESLRVQHEET 204
            EVS            G ++          E   E+ E    EE E  V EE L +  +  
Sbjct: 9488 EVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRV 9547

Query: 205  GLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRES------TEKKRTEPPE 258
              EP E T++      L   +     +PP    PE P++   E        +K++  PP+
Sbjct: 9548 EAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPK 9607

Query: 259  QARLEFLEKEPRKSSEEAGLEPP----EETQPEVPEEMQRKATEEK-------------G 301
                  + +EP+K   E  + P     EE  P    E   + T+E+              
Sbjct: 9608 ------VPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPK 9661

Query: 302  TELPERTKPDFPDHKPRKSTDENVPEP-------------LEEIKLEFPEEESRKTNEET 348
              +PE  K   P+ K  K   +   EP              E++ +E P+ E +   E T
Sbjct: 9662 ARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVT 9721

Query: 349  ILEQSE-----------MMKPESPEEIRKSNEK--KNPQPPEE----------------- 378
            I+E+ E           + + E  EE  + + K  +  +P EE                 
Sbjct: 9722 IMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEE 9781

Query: 379  -----TGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRE-THVEFSKEDRPEPIK--- 429
                 T P  P  + P  EE   TKP     ++  +  P E   V   K+ +P P K   
Sbjct: 9782 HEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPE 9841

Query: 430  SKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVS 489
                V  +++     KR K  +++   K       +  +EE +    + + P  ++  V 
Sbjct: 9842 EPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRV-VAEEKVPVPRKEVAPPVRVPEVP 9900

Query: 490  EECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDE 529
            +E    +P E   E     H +E   L +E +E + E++E
Sbjct: 9901 KEL---EPEEVAFEEEVVTHVEEY--LVEEEEEYIHEEEE 9935



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 99/445 (22%), Positives = 156/445 (35%), Gaps = 74/445 (16%)

Query: 23   PELPGLHKLYENAEP-----DTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQL 77
            P +P L    E  +P     +   KA  K   ++  +P+  T  E+  +  P     +  
Sbjct: 8963 PPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPA 9022

Query: 78   K-PGGTSQEGIAKESK-----RDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHK 131
            K P        A+E K     R    + E     E K    +E   F +  E P DE   
Sbjct: 9023 KAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEV 9082

Query: 132  ESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPG 191
            E   EP E+                  P    P E   E+     +E     + EE E  
Sbjct: 9083 EPYTEPFEQ------------------PYYEEPDEDYEEIKVEAKKE-----VHEEWEED 9119

Query: 192  VPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEK 251
              E     + EE   E  E+ ++ +   ++        +Q  K    E+ E        +
Sbjct: 9120 FEEGQEYYEREEGYDEGEEEWEEAYQEREV--------IQVQKEVYEESHERKVPAKVPE 9171

Query: 252  KRTEPP----EQARLEFLEKEPRKSSEEAG--LEPPEETQPEVPEEMQRKATEEKGTELP 305
            K+  PP    ++  +E +EK  R+  EE     + PE ++  VP++  R   +E+  E+ 
Sbjct: 9172 KKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVK 9231

Query: 306  -----------ERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEES-------RKTNEE 347
                          K  F  H     T+E V   + E++ E   EE        R     
Sbjct: 9232 VPAVHTKKMVISEEKMFFASH-----TEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPP 9286

Query: 348  TILEQSEMMKPE--SPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILE 405
             + E  E   PE  +P  I K  E   P+ PE     +P+E  P    K +     K+ E
Sbjct: 9287 KVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPE 9346

Query: 406  LPDETKPRE-THVEFSKEDRPEPIK 429
            +P +  P E   V  +K+    P K
Sbjct: 9347 VPKKPVPEEKIPVPVAKKKEAPPAK 9371



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 64/277 (23%), Positives = 116/277 (41%), Gaps = 20/277 (7%)

Query: 137  PPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEES 196
            PPEE  P V   + L   + T  +  PP + + EV+   V++   +++ +  E    EE 
Sbjct: 8953 PPEEIPPVVAPPIPL--LLPTPEEKKPPPKRI-EVTKKAVKKDAKKVVAKPKEMTPREEI 9009

Query: 197  LRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEP 256
            ++     T L P +  +    S K  E    T  +     K E  +E +    +K+    
Sbjct: 9010 VKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITR-----KKEVQKEKEAVYEKKQAVHK 9064

Query: 257  PEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHK 316
             ++  +E  E+   +   E   EP E+   E P+E   +   E   E+ E  + DF + +
Sbjct: 9065 EKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQ 9124

Query: 317  PRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP 376
                 +E   E  EE +  + E E  +  +E   E  E   P       K  EKK P PP
Sbjct: 9125 EYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVP------AKVPEKKAPPPP 9178

Query: 377  EETGPVLPQEINPQVEEKTQTKPTEK--ILELPDETK 411
            +    V+ + +  ++E+ ++    EK  + ++P+ +K
Sbjct: 9179 K----VIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK 9211



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 68/280 (24%), Positives = 111/280 (39%), Gaps = 38/280 (13%)

Query: 302  TELPERTKPDFP-DHKPRKSTDENVPEPLEEI-----KLEFPEEESRKTNEETILEQS-- 353
            TEL E  K +F  D +    T  NV    E +     +LE P  E+R T E  +  +   
Sbjct: 8871 TELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLE-PRGEARSTAELYLTTKEIK 8929

Query: 354  -EMMKPESPEE-IRKSNEKKNPQPPEETGPVL----------PQEINP-----QVEEKTQ 396
             E+  P+ P+  +          PPEE  PV+          P+E  P     +V +K  
Sbjct: 8930 LELKPPDIPDSRVPIPTMPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAV 8989

Query: 397  TKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFR 456
             K  +K++  P E  PRE  V+     +P P  +       E+     K  ++ +    R
Sbjct: 8990 KKDAKKVVAKPKEMTPREEIVK-----KPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITR 9044

Query: 457  KEYYALGSLRESEESIGTHYE---FLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEV 513
            K+          E+    H E   F++  ++  +  E   Y++P E Q    E   +++ 
Sbjct: 9045 KKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFE-QPYYEE--PDEDY 9101

Query: 514  VDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEW 553
             ++  E K+ V E+ E   E+G E       +D  E  EW
Sbjct: 9102 EEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGE-EEW 9140



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 60/264 (22%), Positives = 94/264 (35%), Gaps = 52/264 (19%)

Query: 194   EESLRVQHE-ETGLE--PPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTE 250
             EE LR++ E E G    PP ++   F    L  S       P    K E   +  R ST 
Sbjct: 32110 EERLRLEEELELGFSASPPSRSPPHFELSSLRYS------SPQAHVKVEETRKDFRYSTY 32163

Query: 251   KKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQ----PEVPEEMQRKAT-----EEKG 301
                   P +A       E R+   +A    P++ Q        EE+ R  T      E  
Sbjct: 32164 ----HIPTKAEASTSYAELRERHAQAAYRQPKQRQRIMAEREDEELLRPVTTTQHLSEYK 32219

Query: 302   TELPERTKPDFPDHKPRKSTD-ENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES 360
             +EL   +K +    K R+  +   + E  EE ++    +    ++   +L +   + P  
Sbjct: 32220 SELDFMSKEEKSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRRRSLSPTY 32279

Query: 361   PEEIRKSNE--KKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVE 418
              E +R  +E  +  PQP EE                     TE+    P+ T+PR     
Sbjct: 32280 IELMRPVSELIRSRPQPAEE-----------------YEDDTERRSPTPERTRPRS---- 32318

Query: 419   FSKEDRPEPIKSKYSVGNDELEHR 442
                   P P+ S+ S+   E   R
Sbjct: 32319 ------PSPVSSERSLSRFERSAR 32336



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 24/90 (26%), Positives = 40/90 (44%), Gaps = 16/90 (17%)

Query: 340   ESRKTNEETILEQSEMMKPE----SPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKT 395
             +  +  E+ +     +  PE    SPE ++     K+P+P        P+ ++P    +T
Sbjct: 32651 QKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSH------PKAVSPT---ET 32701

Query: 396   QTKPTEKILELPDETKPRETH---VEFSKE 422
             +  PTEK+  LP    P+ T     E SKE
Sbjct: 32702 KPTPTEKVQHLPVSAPPKITQFLKAEASKE 32731


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 111/458 (24%), Positives = 159/458 (34%), Gaps = 57/458 (12%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTM-AKADSKLPAEIY-QEPQPETEEEDFKE 66
           +  P    E  P  P+ P      E A   T  A    K PA    ++P P T +E    
Sbjct: 261 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 320

Query: 67  GEPDSAKNVQLKPGGTSQEGIA---KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
              +       +P  T++E      KE     P +  P   +E    T +E         
Sbjct: 321 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE--------- 371

Query: 124 APMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTE-----TMSEVSGATVRE 178
            P   T KE     P+E  P  T+     SA  T  +P P T      T  E S  T +E
Sbjct: 372 -PAPTTTKEPSPTTPKEPAPTTTK-----SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 425

Query: 179 RNLELLEEETEPGVPEESLRVQHEE----TGLEP-PEQTKQDFPS---EKLGESLEETDL 230
                  +E  P  P++      +E    T  EP P  TK+  P+   E    + +ET  
Sbjct: 426 P-APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 484

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
             PK   P TPE+    + EK     PE+      E+    + EE     P+   P  P+
Sbjct: 485 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 544

Query: 291 EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEE-----IKLEFPEEESRKTN 345
           E      +E     P+   P  P      +     P  L+E      K   P+E +  T 
Sbjct: 545 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 604

Query: 346 EETILEQSEMMKPESPEEIRKSNEK-------KNPQPP----------EETGPVLPQEIN 388
           +E      +   P +P+    +  K       K P P           +E  P  P++  
Sbjct: 605 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 664

Query: 389 PQVEEKTQTK-PTEKILELPDETKPRETHVEFSKEDRP 425
           P+    T TK PT    + P  T P+ET     KE  P
Sbjct: 665 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 90/366 (24%), Positives = 130/366 (35%), Gaps = 30/366 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           ++P P T +E       + A     KP  T+     KE     P ET P   +++   T 
Sbjct: 440 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP----KEPAPTTPKETAPTTPKKLTPTTP 495

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD-PVPPTETMSEV 171
            ++     +  AP   T +E     PEE  P   E+    +     P+ P  P  T  + 
Sbjct: 496 EKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 553

Query: 172 SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
              T  +       +ET P  P+ +       T L+ P  T    P+ K    L  T  +
Sbjct: 554 PAPTTPKEPAPTTPKETAPTTPKGTA-----PTTLKEPAPTTPKKPAPK---ELAPTTTK 605

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPR--KSSEEAGLEPPEETQPEVP 289
            P  T  + P  T  + T    T P E A     E  P   K +    L+ P  T P+ P
Sbjct: 606 EPTSTTCDKPAPTTPKGTAP--TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 663

Query: 290 EEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETI 349
              +   T  KG   P  T  D P     K T    P+       + P   + +T   T 
Sbjct: 664 APKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 720

Query: 350 LEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDE 409
            E S     + P  I KS        P+E+ P L  E  P+  E +  +P     + P  
Sbjct: 721 SEVSTPTTTKEPTTIHKS--------PDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 772

Query: 410 TKPRET 415
           TKP  T
Sbjct: 773 TKPEMT 778



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 101/448 (22%), Positives = 153/448 (34%), Gaps = 66/448 (14%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIY----QEPQPETEEEDF 64
           ++ P    +L P  PE            P T  K     P E+     +EP P T EE  
Sbjct: 481 ETAPTTPKKLTPTTPE---------KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 531

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
                 +A N   +P  T+     KE     P E  P   +E    T +  G     L+ 
Sbjct: 532 PTTPKAAAPNTPKEPAPTTP----KEPAPTTPKEPAPTTPKETAPTTPK--GTAPTTLKE 585

Query: 125 PMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD---------PVPPTETMSEVSGAT 175
           P   T K+     P+E  P  T++    +  +  P          P  P  T  +    T
Sbjct: 586 PAPTTPKKP---APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 642

Query: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
             +       +E  P  P++    +   T  + P  T  D P+    +    T  + P  
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 702

Query: 236 TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGL-EPPEETQPEVPEEMQR 294
           T P+ P  T  E      T PP  + +      P  + E   + + P+E+ PE+  E   
Sbjct: 703 TTPKKPAPTTPE------TPPPTTSEVS----TPTTTKEPTTIHKSPDESTPELSAEPTP 752

Query: 295 KATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
           KA E    E      P  P  K   +T    PE     K +  E + R T E T    + 
Sbjct: 753 KALENSPKE------PGVPTTKTPAATK---PEMTTTAKDKTTERDLRTTPETTTA--AP 801

Query: 355 MMKPESPEEIRKSNEKKNPQPPEETGPVLPQE-------------INPQVEEKTQTKPTE 401
            M  E+     K+ E K      +      Q+             + P+V    +T  T 
Sbjct: 802 KMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT 861

Query: 402 KILELPDETKPRETHVEFSKEDRPEPIK 429
           +I+  P+ET   +     SK   P+P K
Sbjct: 862 EIMNKPEETAKPKDRATNSKATTPKPQK 889



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 85/366 (23%), Positives = 129/366 (35%), Gaps = 43/366 (11%)

Query: 85  EGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPN 144
           + I K S +D+   ++       K+ET+ + G      + P   T KE     P+E  P 
Sbjct: 177 QSIEKTSAKDLAPTSKVLAKPTPKAETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPT 235

Query: 145 VTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE- 203
                 ++SA  T  +P P T      S  T  +       +E  P  P+E      +E 
Sbjct: 236 T-----IKSAPTTPKEPAPTTTK----SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP 286

Query: 204 ------TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
                 +    P++     P +    + +E     PK   P TP+E    + E   T P 
Sbjct: 287 APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK 346

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPE-------ETQPEVPEEMQRKATEEKGTELPE---- 306
           E A     +  P    E A   P E       E  P  P+E     T+   T   E    
Sbjct: 347 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 406

Query: 307 --RTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEI 364
             ++ P  P      +T E  P   +E     P++ +  T +E          P +P+E 
Sbjct: 407 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--------PTTPKEP 458

Query: 365 RKSNEKKN-PQPPEETGPVLPQEINPQVEEKTQTKPTEKIL----ELPDETKPRETHVEF 419
             +  KK  P  P+E  P  P+E  P   +K      EK+     E P  T P E     
Sbjct: 459 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 518

Query: 420 SKEDRP 425
            +E  P
Sbjct: 519 PEEPTP 524



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 94/418 (22%), Positives = 147/418 (35%), Gaps = 82/418 (19%)

Query: 33  ENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSA----KNVQLKPGGTSQEGIA 88
           +N +  T  K   K P  +  E     +  DFK   PD++      V   P  T+ + I 
Sbjct: 68  DNKKNRTKKKPTPKPP--VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN 125

Query: 89  KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEA-KPNVTE 147
                   S+T       V  ET+ E  E           T+K++  +  E+      T+
Sbjct: 126 PRPSLPPNSDTSKETSLTVNKETTVETKE--------TTTTNKQTSTDGKEKTTSAKETQ 177

Query: 148 DVFLESAMETDPD------PVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQH 201
            +   SA +  P       P P  ET ++    T          +E  P  P+E      
Sbjct: 178 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--------PKEPTPTTPKE------ 223

Query: 202 EETGLEPPEQTKQDFPSEKLGESLEETDLQP-PKMTK--PETPEETQREST-EKKRTEPP 257
                  P  T    P+    +S   T  +P P  TK  P TP+E    +T E   T P 
Sbjct: 224 -------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 276

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKP 317
           E A      KEP  ++ ++    P+E  P  P++      +E     P+   P  P  +P
Sbjct: 277 EPAPTT--TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPK-EP 333

Query: 318 RKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE 377
             +T E  P   +E     P++ +                P +P+E         P  P+
Sbjct: 334 APTTKEPAPTTPKEPAPTAPKKPA----------------PTTPKE-------PAPTTPK 370

Query: 378 ETGPVLPQEINPQVEEK-----TQTKPTEKILELPDETK-----PRETHVEFSKEDRP 425
           E  P   +E +P   ++     T++ PT      P  TK     P+E     +KE  P
Sbjct: 371 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 428



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 58/324 (17%)

Query: 134 DLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVP 193
           D    +  K + +  +     +   P   P ++T  E S    +E  +E  E  T     
Sbjct: 103 DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT---- 158

Query: 194 EESLRVQHEETGLEPPEQTKQDFPSEKLGESLEET---DLQPPK--MTKPETPEETQRES 248
                  +++T  +  E+T     S K  +S+E+T   DL P    + KP    ET   +
Sbjct: 159 -------NKQTSTDGKEKTT----SAKETQSIEKTSAKDLAPTSKVLAKPTPKAET---T 204

Query: 249 TEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEET---------------------QPE 287
           T+      P+       E  P    E A   P E T                      P 
Sbjct: 205 TKGPALTTPK-------EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 257

Query: 288 VPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEE 347
            P+E     T+E     P+   P     +P  +T ++ P   +E     P++ +  T +E
Sbjct: 258 TPKEPAPTTTKEPAPTTPKEPAPT-TTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 316

Query: 348 TILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQV-EEKTQTKPTEKILEL 406
                 +   P +P+E   + ++  P  P+E  P  P++  P   +E   T P E     
Sbjct: 317 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE----- 371

Query: 407 PDETKPRETHVEFSKEDRPEPIKS 430
           P  T  +E      KE  P   KS
Sbjct: 372 PAPTTTKEPSPTTPKEPAPTTTKS 395



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 65/282 (23%), Positives = 103/282 (36%), Gaps = 39/282 (13%)

Query: 200 QHEETGLEPPEQTKQDF-PSEKL---GESLEETDLQPPKMTKPETPEET----------Q 245
           QH +    P   T +   P   L    ++ +ET L   K T  ET E T          +
Sbjct: 108 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 167

Query: 246 RESTEKKRTEPPEQARLEFL--------EKEPRKSSEEAG--LEPPEETQPEVPEEMQRK 295
            ++T  K T+  E+   + L        +  P+  +   G  L  P+E  P  P+E    
Sbjct: 168 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE-PAS 226

Query: 296 ATEEKGTELPERTKPDFPDHKPRKSTDENVP----EPLEEIKLE----FPEEESRKTNEE 347
            T ++ T    ++ P  P  +P  +T ++ P    EP      E     P+E +  T +E
Sbjct: 227 TTPKEPTPTTIKSAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 285

Query: 348 TILEQSEMMKPESPEEIRKSNEKK----NPQPPEETGPVLPQEINPQVEEKTQTKPTEKI 403
                ++   P +P+E   +  KK     P+ P  T P  P    P+    T  +P    
Sbjct: 286 PAPTTTKSA-PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 344

Query: 404 LELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPK 445
            + P  T P++      KE  P   K        E     PK
Sbjct: 345 PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPK 386


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 111/458 (24%), Positives = 159/458 (34%), Gaps = 57/458 (12%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTM-AKADSKLPAEIY-QEPQPETEEEDFKE 66
           +  P    E  P  P+ P      E A   T  A    K PA    ++P P T +E    
Sbjct: 302 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 361

Query: 67  GEPDSAKNVQLKPGGTSQEGIA---KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
              +       +P  T++E      KE     P +  P   +E    T +E         
Sbjct: 362 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE--------- 412

Query: 124 APMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTE-----TMSEVSGATVRE 178
            P   T KE     P+E  P  T+     SA  T  +P P T      T  E S  T +E
Sbjct: 413 -PAPTTTKEPSPTTPKEPAPTTTK-----SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 466

Query: 179 RNLELLEEETEPGVPEESLRVQHEE----TGLEP-PEQTKQDFPS---EKLGESLEETDL 230
                  +E  P  P++      +E    T  EP P  TK+  P+   E    + +ET  
Sbjct: 467 P-APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 525

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
             PK   P TPE+    + EK     PE+      E+    + EE     P+   P  P+
Sbjct: 526 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 585

Query: 291 EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEE-----IKLEFPEEESRKTN 345
           E      +E     P+   P  P      +     P  L+E      K   P+E +  T 
Sbjct: 586 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 645

Query: 346 EETILEQSEMMKPESPEEIRKSNEK-------KNPQPP----------EETGPVLPQEIN 388
           +E      +   P +P+    +  K       K P P           +E  P  P++  
Sbjct: 646 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 705

Query: 389 PQVEEKTQTK-PTEKILELPDETKPRETHVEFSKEDRP 425
           P+    T TK PT    + P  T P+ET     KE  P
Sbjct: 706 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 90/366 (24%), Positives = 130/366 (35%), Gaps = 30/366 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           ++P P T +E       + A     KP  T+     KE     P ET P   +++   T 
Sbjct: 481 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP----KEPAPTTPKETAPTTPKKLTPTTP 536

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD-PVPPTETMSEV 171
            ++     +  AP   T +E     PEE  P   E+    +     P+ P  P  T  + 
Sbjct: 537 EKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 594

Query: 172 SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
              T  +       +ET P  P+ +       T L+ P  T    P+ K    L  T  +
Sbjct: 595 PAPTTPKEPAPTTPKETAPTTPKGTA-----PTTLKEPAPTTPKKPAPK---ELAPTTTK 646

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPR--KSSEEAGLEPPEETQPEVP 289
            P  T  + P  T  + T    T P E A     E  P   K +    L+ P  T P+ P
Sbjct: 647 EPTSTTCDKPAPTTPKGTAP--TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 704

Query: 290 EEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETI 349
              +   T  KG   P  T  D P     K T    P+       + P   + +T   T 
Sbjct: 705 APKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 761

Query: 350 LEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDE 409
            E S     + P  I KS        P+E+ P L  E  P+  E +  +P     + P  
Sbjct: 762 SEVSTPTTTKEPTTIHKS--------PDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 813

Query: 410 TKPRET 415
           TKP  T
Sbjct: 814 TKPEMT 819



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 101/448 (22%), Positives = 153/448 (34%), Gaps = 66/448 (14%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIY----QEPQPETEEEDF 64
           ++ P    +L P  PE            P T  K     P E+     +EP P T EE  
Sbjct: 522 ETAPTTPKKLTPTTPE---------KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 572

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
                 +A N   +P  T+     KE     P E  P   +E    T +  G     L+ 
Sbjct: 573 PTTPKAAAPNTPKEPAPTTP----KEPAPTTPKEPAPTTPKETAPTTPK--GTAPTTLKE 626

Query: 125 PMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD---------PVPPTETMSEVSGAT 175
           P   T K+     P+E  P  T++    +  +  P          P  P  T  +    T
Sbjct: 627 PAPTTPKKP---APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 683

Query: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
             +       +E  P  P++    +   T  + P  T  D P+    +    T  + P  
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 743

Query: 236 TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGL-EPPEETQPEVPEEMQR 294
           T P+ P  T  E      T PP  + +      P  + E   + + P+E+ PE+  E   
Sbjct: 744 TTPKKPAPTTPE------TPPPTTSEVS----TPTTTKEPTTIHKSPDESTPELSAEPTP 793

Query: 295 KATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
           KA E    E      P  P  K   +T    PE     K +  E + R T E T    + 
Sbjct: 794 KALENSPKE------PGVPTTKTPAATK---PEMTTTAKDKTTERDLRTTPETTTA--AP 842

Query: 355 MMKPESPEEIRKSNEKKNPQPPEETGPVLPQE-------------INPQVEEKTQTKPTE 401
            M  E+     K+ E K      +      Q+             + P+V    +T  T 
Sbjct: 843 KMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT 902

Query: 402 KILELPDETKPRETHVEFSKEDRPEPIK 429
           +I+  P+ET   +     SK   P+P K
Sbjct: 903 EIMNKPEETAKPKDRATNSKATTPKPQK 930



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 85/366 (23%), Positives = 129/366 (35%), Gaps = 43/366 (11%)

Query: 85  EGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPN 144
           + I K S +D+   ++       K+ET+ + G      + P   T KE     P+E  P 
Sbjct: 218 QSIEKTSAKDLAPTSKVLAKPTPKAETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPT 276

Query: 145 VTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE- 203
                 ++SA  T  +P P T      S  T  +       +E  P  P+E      +E 
Sbjct: 277 T-----IKSAPTTPKEPAPTTTK----SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP 327

Query: 204 ------TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
                 +    P++     P +    + +E     PK   P TP+E    + E   T P 
Sbjct: 328 APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK 387

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPE-------ETQPEVPEEMQRKATEEKGTELPE---- 306
           E A     +  P    E A   P E       E  P  P+E     T+   T   E    
Sbjct: 388 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 447

Query: 307 --RTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEI 364
             ++ P  P      +T E  P   +E     P++ +  T +E          P +P+E 
Sbjct: 448 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--------PTTPKEP 499

Query: 365 RKSNEKKN-PQPPEETGPVLPQEINPQVEEKTQTKPTEKIL----ELPDETKPRETHVEF 419
             +  KK  P  P+E  P  P+E  P   +K      EK+     E P  T P E     
Sbjct: 500 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 559

Query: 420 SKEDRP 425
            +E  P
Sbjct: 560 PEEPTP 565



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 94/418 (22%), Positives = 147/418 (35%), Gaps = 82/418 (19%)

Query: 33  ENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSA----KNVQLKPGGTSQEGIA 88
           +N +  T  K   K P  +  E     +  DFK   PD++      V   P  T+ + I 
Sbjct: 109 DNKKNRTKKKPTPKPP--VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN 166

Query: 89  KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEA-KPNVTE 147
                   S+T       V  ET+ E  E           T+K++  +  E+      T+
Sbjct: 167 PRPSLPPNSDTSKETSLTVNKETTVETKE--------TTTTNKQTSTDGKEKTTSAKETQ 218

Query: 148 DVFLESAMETDPD------PVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQH 201
            +   SA +  P       P P  ET ++    T          +E  P  P+E      
Sbjct: 219 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--------PKEPTPTTPKE------ 264

Query: 202 EETGLEPPEQTKQDFPSEKLGESLEETDLQP-PKMTK--PETPEETQREST-EKKRTEPP 257
                  P  T    P+    +S   T  +P P  TK  P TP+E    +T E   T P 
Sbjct: 265 -------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPK 317

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKP 317
           E A      KEP  ++ ++    P+E  P  P++      +E     P+   P  P  +P
Sbjct: 318 EPAPTT--TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPK-EP 374

Query: 318 RKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE 377
             +T E  P   +E     P++ +                P +P+E         P  P+
Sbjct: 375 APTTKEPAPTTPKEPAPTAPKKPA----------------PTTPKE-------PAPTTPK 411

Query: 378 ETGPVLPQEINPQVEEK-----TQTKPTEKILELPDETK-----PRETHVEFSKEDRP 425
           E  P   +E +P   ++     T++ PT      P  TK     P+E     +KE  P
Sbjct: 412 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 469



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 58/324 (17%)

Query: 134 DLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVP 193
           D    +  K + +  +     +   P   P ++T  E S    +E  +E  E  T     
Sbjct: 144 DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTT---- 199

Query: 194 EESLRVQHEETGLEPPEQTKQDFPSEKLGESLEET---DLQPPK--MTKPETPEETQRES 248
                  +++T  +  E+T     S K  +S+E+T   DL P    + KP    ET   +
Sbjct: 200 -------NKQTSTDGKEKTT----SAKETQSIEKTSAKDLAPTSKVLAKPTPKAET---T 245

Query: 249 TEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEET---------------------QPE 287
           T+      P+       E  P    E A   P E T                      P 
Sbjct: 246 TKGPALTTPK-------EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPT 298

Query: 288 VPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEE 347
            P+E     T+E     P+   P     +P  +T ++ P   +E     P++ +  T +E
Sbjct: 299 TPKEPAPTTTKEPAPTTPKEPAPT-TTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKE 357

Query: 348 TILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQV-EEKTQTKPTEKILEL 406
                 +   P +P+E   + ++  P  P+E  P  P++  P   +E   T P E     
Sbjct: 358 PAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE----- 412

Query: 407 PDETKPRETHVEFSKEDRPEPIKS 430
           P  T  +E      KE  P   KS
Sbjct: 413 PAPTTTKEPSPTTPKEPAPTTTKS 436



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 65/282 (23%), Positives = 103/282 (36%), Gaps = 39/282 (13%)

Query: 200 QHEETGLEPPEQTKQDF-PSEKL---GESLEETDLQPPKMTKPETPEET----------Q 245
           QH +    P   T +   P   L    ++ +ET L   K T  ET E T          +
Sbjct: 149 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGK 208

Query: 246 RESTEKKRTEPPEQARLEFL--------EKEPRKSSEEAG--LEPPEETQPEVPEEMQRK 295
            ++T  K T+  E+   + L        +  P+  +   G  L  P+E  P  P+E    
Sbjct: 209 EKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKE-PAS 267

Query: 296 ATEEKGTELPERTKPDFPDHKPRKSTDENVP----EPLEEIKLE----FPEEESRKTNEE 347
            T ++ T    ++ P  P  +P  +T ++ P    EP      E     P+E +  T +E
Sbjct: 268 TTPKEPTPTTIKSAPTTPK-EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 326

Query: 348 TILEQSEMMKPESPEEIRKSNEKK----NPQPPEETGPVLPQEINPQVEEKTQTKPTEKI 403
                ++   P +P+E   +  KK     P+ P  T P  P    P+    T  +P    
Sbjct: 327 PAPTTTKSA-PTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 385

Query: 404 LELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPK 445
            + P  T P++      KE  P   K        E     PK
Sbjct: 386 PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPK 427


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 111/458 (24%), Positives = 159/458 (34%), Gaps = 57/458 (12%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTM-AKADSKLPAEIY-QEPQPETEEEDFKE 66
           +  P    E  P  P+ P      E A   T  A    K PA    ++P P T +E    
Sbjct: 354 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 413

Query: 67  GEPDSAKNVQLKPGGTSQEGIA---KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
              +       +P  T++E      KE     P +  P   +E    T +E         
Sbjct: 414 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE--------- 464

Query: 124 APMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTE-----TMSEVSGATVRE 178
            P   T KE     P+E  P  T+     SA  T  +P P T      T  E S  T +E
Sbjct: 465 -PAPTTTKEPSPTTPKEPAPTTTK-----SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 518

Query: 179 RNLELLEEETEPGVPEESLRVQHEE----TGLEP-PEQTKQDFPS---EKLGESLEETDL 230
                  +E  P  P++      +E    T  EP P  TK+  P+   E    + +ET  
Sbjct: 519 P-APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 577

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
             PK   P TPE+    + EK     PE+      E+    + EE     P+   P  P+
Sbjct: 578 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 637

Query: 291 EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEE-----IKLEFPEEESRKTN 345
           E      +E     P+   P  P      +     P  L+E      K   P+E +  T 
Sbjct: 638 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 697

Query: 346 EETILEQSEMMKPESPEEIRKSNEK-------KNPQPP----------EETGPVLPQEIN 388
           +E      +   P +P+    +  K       K P P           +E  P  P++  
Sbjct: 698 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 757

Query: 389 PQVEEKTQTK-PTEKILELPDETKPRETHVEFSKEDRP 425
           P+    T TK PT    + P  T P+ET     KE  P
Sbjct: 758 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 795



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 90/366 (24%), Positives = 130/366 (35%), Gaps = 30/366 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           ++P P T +E       + A     KP  T+     KE     P ET P   +++   T 
Sbjct: 533 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP----KEPAPTTPKETAPTTPKKLTPTTP 588

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD-PVPPTETMSEV 171
            ++     +  AP   T +E     PEE  P   E+    +     P+ P  P  T  + 
Sbjct: 589 EKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 646

Query: 172 SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
              T  +       +ET P  P+ +       T L+ P  T    P+ K    L  T  +
Sbjct: 647 PAPTTPKEPAPTTPKETAPTTPKGTA-----PTTLKEPAPTTPKKPAPK---ELAPTTTK 698

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPR--KSSEEAGLEPPEETQPEVP 289
            P  T  + P  T  + T    T P E A     E  P   K +    L+ P  T P+ P
Sbjct: 699 EPTSTTCDKPAPTTPKGTAP--TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 756

Query: 290 EEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETI 349
              +   T  KG   P  T  D P     K T    P+       + P   + +T   T 
Sbjct: 757 APKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 813

Query: 350 LEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDE 409
            E S     + P  I KS        P+E+ P L  E  P+  E +  +P     + P  
Sbjct: 814 SEVSTPTTTKEPTTIHKS--------PDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 865

Query: 410 TKPRET 415
           TKP  T
Sbjct: 866 TKPEMT 871



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 101/448 (22%), Positives = 153/448 (34%), Gaps = 66/448 (14%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIY----QEPQPETEEEDF 64
           ++ P    +L P  PE            P T  K     P E+     +EP P T EE  
Sbjct: 574 ETAPTTPKKLTPTTPE---------KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 624

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
                 +A N   +P  T+     KE     P E  P   +E    T +  G     L+ 
Sbjct: 625 PTTPKAAAPNTPKEPAPTTP----KEPAPTTPKEPAPTTPKETAPTTPK--GTAPTTLKE 678

Query: 125 PMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD---------PVPPTETMSEVSGAT 175
           P   T K+     P+E  P  T++    +  +  P          P  P  T  +    T
Sbjct: 679 PAPTTPKKP---APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 735

Query: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
             +       +E  P  P++    +   T  + P  T  D P+    +    T  + P  
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 795

Query: 236 TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGL-EPPEETQPEVPEEMQR 294
           T P+ P  T  E      T PP  + +      P  + E   + + P+E+ PE+  E   
Sbjct: 796 TTPKKPAPTTPE------TPPPTTSEVS----TPTTTKEPTTIHKSPDESTPELSAEPTP 845

Query: 295 KATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
           KA E    E      P  P  K   +T    PE     K +  E + R T E T    + 
Sbjct: 846 KALENSPKE------PGVPTTKTPAATK---PEMTTTAKDKTTERDLRTTPETTTA--AP 894

Query: 355 MMKPESPEEIRKSNEKKNPQPPEETGPVLPQE-------------INPQVEEKTQTKPTE 401
            M  E+     K+ E K      +      Q+             + P+V    +T  T 
Sbjct: 895 KMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT 954

Query: 402 KILELPDETKPRETHVEFSKEDRPEPIK 429
           +I+  P+ET   +     SK   P+P K
Sbjct: 955 EIMNKPEETAKPKDRATNSKATTPKPQK 982



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 85/366 (23%), Positives = 129/366 (35%), Gaps = 43/366 (11%)

Query: 85  EGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPN 144
           + I K S +D+   ++       K+ET+ + G      + P   T KE     P+E  P 
Sbjct: 270 QSIEKTSAKDLAPTSKVLAKPTPKAETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPT 328

Query: 145 VTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE- 203
                 ++SA  T  +P P T      S  T  +       +E  P  P+E      +E 
Sbjct: 329 T-----IKSAPTTPKEPAPTTTK----SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP 379

Query: 204 ------TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
                 +    P++     P +    + +E     PK   P TP+E    + E   T P 
Sbjct: 380 APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK 439

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPE-------ETQPEVPEEMQRKATEEKGTELPE---- 306
           E A     +  P    E A   P E       E  P  P+E     T+   T   E    
Sbjct: 440 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 499

Query: 307 --RTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEI 364
             ++ P  P      +T E  P   +E     P++ +  T +E          P +P+E 
Sbjct: 500 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--------PTTPKEP 551

Query: 365 RKSNEKKN-PQPPEETGPVLPQEINPQVEEKTQTKPTEKIL----ELPDETKPRETHVEF 419
             +  KK  P  P+E  P  P+E  P   +K      EK+     E P  T P E     
Sbjct: 552 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 611

Query: 420 SKEDRP 425
            +E  P
Sbjct: 612 PEEPTP 617



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 97/427 (22%), Positives = 151/427 (35%), Gaps = 82/427 (19%)

Query: 24  ELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSA----KNVQLKP 79
           EL    K+ +N +  T  K   K P  +  E     +  DFK   PD++      V   P
Sbjct: 152 ELQKKLKVKDNKKNRTKKKPTPKPP--VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSP 209

Query: 80  GGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPE 139
             T+ + I         S+T       V  ET+ E  E           T+K++  +  E
Sbjct: 210 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE--------TTTTNKQTSTDGKE 261

Query: 140 EA-KPNVTEDVFLESAMETDPD------PVPPTETMSEVSGATVRERNLELLEEETEPGV 192
           +      T+ +   SA +  P       P P  ET ++    T          +E  P  
Sbjct: 262 KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--------PKEPTPTT 313

Query: 193 PEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQP-PKMTK--PETPEETQREST 249
           P+E             P  T    P+    +S   T  +P P  TK  P TP+E    +T
Sbjct: 314 PKE-------------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 360

Query: 250 -EKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERT 308
            E   T P E A      KEP  ++ ++    P+E  P  P++      +E     P+  
Sbjct: 361 KEPAPTTPKEPAPTT--TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 418

Query: 309 KPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSN 368
            P  P  +P  +T E  P   +E     P++ +                P +P+E     
Sbjct: 419 TPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPA----------------PTTPKE----- 456

Query: 369 EKKNPQPPEETGPVLPQEINPQVEEK-----TQTKPTEKILELPDETK-----PRETHVE 418
               P  P+E  P   +E +P   ++     T++ PT      P  TK     P+E    
Sbjct: 457 --PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT 514

Query: 419 FSKEDRP 425
            +KE  P
Sbjct: 515 TTKEPAP 521



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/431 (20%), Positives = 156/431 (36%), Gaps = 69/431 (16%)

Query: 43  ADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPG 102
           A   + +   + P+P  +++  K  E   ++ +  +   +  +  +  S     S T   
Sbjct: 84  ASQTIKSTTKRSPKPPNKKKTKKVIE---SEEITEEHSVSENQESSSSSSSSSSSSTIRK 140

Query: 103 IHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPP--EEAKPNVTEDVFLESAMETDPD 160
           I     S  +RE+ +  K  +   + T K+   +PP  +EA   +    F  +  +T   
Sbjct: 141 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 200

Query: 161 PVPPTETMSEVSGA--------------TVRERNLELLEEETEPGVPEESLRVQHEETGL 206
                 T  +++ A              T +E +L + +E T   V  +     +++T  
Sbjct: 201 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETT---VETKETTTTNKQTST 257

Query: 207 EPPEQTKQDFPSEKLGESLEET---DLQPPK--MTKPETPEETQRESTEKKRTEPPEQAR 261
           +  E+T     S K  +S+E+T   DL P    + KP    ET   +T+      P+   
Sbjct: 258 DGKEKTT----SAKETQSIEKTSAKDLAPTSKVLAKPTPKAET---TTKGPALTTPK--- 307

Query: 262 LEFLEKEPRKSSEEAGLEPPEET---------------------QPEVPEEMQRKATEEK 300
               E  P    E A   P E T                      P  P+E     T+E 
Sbjct: 308 ----EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP 363

Query: 301 GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES 360
               P+   P     +P  +T ++ P   +E     P++ +  T +E      +   P +
Sbjct: 364 APTTPKEPAPT-TTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT 422

Query: 361 PEEIRKSNEKKNPQPPEETGPVLPQEINPQV-EEKTQTKPTEKILELPDETKPRETHVEF 419
           P+E   + ++  P  P+E  P  P++  P   +E   T P E     P  T  +E     
Sbjct: 423 PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE-----PAPTTTKEPSPTT 477

Query: 420 SKEDRPEPIKS 430
            KE  P   KS
Sbjct: 478 PKEPAPTTTKS 488


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 111/458 (24%), Positives = 159/458 (34%), Gaps = 57/458 (12%)

Query: 9   DSGPDEDGELEPERPELPGLHKLYENAEPDTM-AKADSKLPAEIY-QEPQPETEEEDFKE 66
           +  P    E  P  P+ P      E A   T  A    K PA    ++P P T +E    
Sbjct: 395 EPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT 454

Query: 67  GEPDSAKNVQLKPGGTSQEGIA---KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLE 123
              +       +P  T++E      KE     P +  P   +E    T +E         
Sbjct: 455 TPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE--------- 505

Query: 124 APMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTE-----TMSEVSGATVRE 178
            P   T KE     P+E  P  T+     SA  T  +P P T      T  E S  T +E
Sbjct: 506 -PAPTTTKEPSPTTPKEPAPTTTK-----SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 559

Query: 179 RNLELLEEETEPGVPEESLRVQHEE----TGLEP-PEQTKQDFPS---EKLGESLEETDL 230
                  +E  P  P++      +E    T  EP P  TK+  P+   E    + +ET  
Sbjct: 560 P-APTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAP 618

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
             PK   P TPE+    + EK     PE+      E+    + EE     P+   P  P+
Sbjct: 619 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 678

Query: 291 EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEE-----IKLEFPEEESRKTN 345
           E      +E     P+   P  P      +     P  L+E      K   P+E +  T 
Sbjct: 679 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 738

Query: 346 EETILEQSEMMKPESPEEIRKSNEK-------KNPQPP----------EETGPVLPQEIN 388
           +E      +   P +P+    +  K       K P P           +E  P  P++  
Sbjct: 739 KEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPA 798

Query: 389 PQVEEKTQTK-PTEKILELPDETKPRETHVEFSKEDRP 425
           P+    T TK PT    + P  T P+ET     KE  P
Sbjct: 799 PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 836



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 90/366 (24%), Positives = 130/366 (35%), Gaps = 30/366 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           ++P P T +E       + A     KP  T+     KE     P ET P   +++   T 
Sbjct: 574 KKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTP----KEPAPTTPKETAPTTPKKLTPTTP 629

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD-PVPPTETMSEV 171
            ++     +  AP   T +E     PEE  P   E+    +     P+ P  P  T  + 
Sbjct: 630 EKLAPTTPEKPAPT--TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKE 687

Query: 172 SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
              T  +       +ET P  P+ +       T L+ P  T    P+ K    L  T  +
Sbjct: 688 PAPTTPKEPAPTTPKETAPTTPKGTA-----PTTLKEPAPTTPKKPAPK---ELAPTTTK 739

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPR--KSSEEAGLEPPEETQPEVP 289
            P  T  + P  T  + T    T P E A     E  P   K +    L+ P  T P+ P
Sbjct: 740 EPTSTTCDKPAPTTPKGTAP--TTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 797

Query: 290 EEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETI 349
              +   T  KG   P  T  D P     K T    P+       + P   + +T   T 
Sbjct: 798 APKELAPTTTKG---PTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTT 854

Query: 350 LEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDE 409
            E S     + P  I KS        P+E+ P L  E  P+  E +  +P     + P  
Sbjct: 855 SEVSTPTTTKEPTTIHKS--------PDESTPELSAEPTPKALENSPKEPGVPTTKTPAA 906

Query: 410 TKPRET 415
           TKP  T
Sbjct: 907 TKPEMT 912



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 101/448 (22%), Positives = 153/448 (34%), Gaps = 66/448 (14%)

Query: 9    DSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIY----QEPQPETEEEDF 64
            ++ P    +L P  PE            P T  K     P E+     +EP P T EE  
Sbjct: 615  ETAPTTPKKLTPTTPE---------KLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPA 665

Query: 65   KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
                  +A N   +P  T+     KE     P E  P   +E    T +  G     L+ 
Sbjct: 666  PTTPKAAAPNTPKEPAPTTP----KEPAPTTPKEPAPTTPKETAPTTPK--GTAPTTLKE 719

Query: 125  PMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD---------PVPPTETMSEVSGAT 175
            P   T K+     P+E  P  T++    +  +  P          P  P  T  +    T
Sbjct: 720  PAPTTPKKP---APKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPT 776

Query: 176  VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
              +       +E  P  P++    +   T  + P  T  D P+    +    T  + P  
Sbjct: 777  TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAP 836

Query: 236  TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGL-EPPEETQPEVPEEMQR 294
            T P+ P  T  E      T PP  + +      P  + E   + + P+E+ PE+  E   
Sbjct: 837  TTPKKPAPTTPE------TPPPTTSEVS----TPTTTKEPTTIHKSPDESTPELSAEPTP 886

Query: 295  KATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
            KA E    E      P  P  K   +T    PE     K +  E + R T E T    + 
Sbjct: 887  KALENSPKE------PGVPTTKTPAATK---PEMTTTAKDKTTERDLRTTPETTTA--AP 935

Query: 355  MMKPESPEEIRKSNEKKNPQPPEETGPVLPQE-------------INPQVEEKTQTKPTE 401
             M  E+     K+ E K      +      Q+             + P+V    +T  T 
Sbjct: 936  KMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTT 995

Query: 402  KILELPDETKPRETHVEFSKEDRPEPIK 429
            +I+  P+ET   +     SK   P+P K
Sbjct: 996  EIMNKPEETAKPKDRATNSKATTPKPQK 1023



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 85/366 (23%), Positives = 129/366 (35%), Gaps = 43/366 (11%)

Query: 85  EGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPN 144
           + I K S +D+   ++       K+ET+ + G      + P   T KE     P+E  P 
Sbjct: 311 QSIEKTSAKDLAPTSKVLAKPTPKAETTTK-GPALTTPKEPTPTTPKEPASTTPKEPTPT 369

Query: 145 VTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE- 203
                 ++SA  T  +P P T      S  T  +       +E  P  P+E      +E 
Sbjct: 370 T-----IKSAPTTPKEPAPTTTK----SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEP 420

Query: 204 ------TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
                 +    P++     P +    + +E     PK   P TP+E    + E   T P 
Sbjct: 421 APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPK 480

Query: 258 EQARLEFLEKEPRKSSEEAGLEPPE-------ETQPEVPEEMQRKATEEKGTELPE---- 306
           E A     +  P    E A   P E       E  P  P+E     T+   T   E    
Sbjct: 481 EPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 540

Query: 307 --RTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEI 364
             ++ P  P      +T E  P   +E     P++ +  T +E          P +P+E 
Sbjct: 541 TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPA--------PTTPKEP 592

Query: 365 RKSNEKKN-PQPPEETGPVLPQEINPQVEEKTQTKPTEKIL----ELPDETKPRETHVEF 419
             +  KK  P  P+E  P  P+E  P   +K      EK+     E P  T P E     
Sbjct: 593 APTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT 652

Query: 420 SKEDRP 425
            +E  P
Sbjct: 653 PEEPTP 658



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 97/427 (22%), Positives = 151/427 (35%), Gaps = 82/427 (19%)

Query: 24  ELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSA----KNVQLKP 79
           EL    K+ +N +  T  K   K P  +  E     +  DFK   PD++      V   P
Sbjct: 193 ELQKKLKVKDNKKNRTKKKPTPKPP--VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSP 250

Query: 80  GGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPE 139
             T+ + I         S+T       V  ET+ E  E           T+K++  +  E
Sbjct: 251 KITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKE--------TTTTNKQTSTDGKE 302

Query: 140 EA-KPNVTEDVFLESAMETDPD------PVPPTETMSEVSGATVRERNLELLEEETEPGV 192
           +      T+ +   SA +  P       P P  ET ++    T          +E  P  
Sbjct: 303 KTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTT--------PKEPTPTT 354

Query: 193 PEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQP-PKMTK--PETPEETQREST 249
           P+E             P  T    P+    +S   T  +P P  TK  P TP+E    +T
Sbjct: 355 PKE-------------PASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 401

Query: 250 -EKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERT 308
            E   T P E A      KEP  ++ ++    P+E  P  P++      +E     P+  
Sbjct: 402 KEPAPTTPKEPAPTT--TKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 459

Query: 309 KPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSN 368
            P  P  +P  +T E  P   +E     P++ +                P +P+E     
Sbjct: 460 TPTTPK-EPAPTTKEPAPTTPKEPAPTAPKKPA----------------PTTPKE----- 497

Query: 369 EKKNPQPPEETGPVLPQEINPQVEEK-----TQTKPTEKILELPDETK-----PRETHVE 418
               P  P+E  P   +E +P   ++     T++ PT      P  TK     P+E    
Sbjct: 498 --PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPT 555

Query: 419 FSKEDRP 425
            +KE  P
Sbjct: 556 TTKEPAP 562



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 88/431 (20%), Positives = 156/431 (36%), Gaps = 69/431 (16%)

Query: 43  ADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPG 102
           A   + +   + P+P  +++  K  E   ++ +  +   +  +  +  S     S T   
Sbjct: 125 ASQTIKSTTKRSPKPPNKKKTKKVIE---SEEITEEHSVSENQESSSSSSSSSSSSTIRK 181

Query: 103 IHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPP--EEAKPNVTEDVFLESAMETDPD 160
           I     S  +RE+ +  K  +   + T K+   +PP  +EA   +    F  +  +T   
Sbjct: 182 IKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTT 241

Query: 161 PVPPTETMSEVSGA--------------TVRERNLELLEEETEPGVPEESLRVQHEETGL 206
                 T  +++ A              T +E +L + +E T   V  +     +++T  
Sbjct: 242 QHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETT---VETKETTTTNKQTST 298

Query: 207 EPPEQTKQDFPSEKLGESLEET---DLQPPK--MTKPETPEETQRESTEKKRTEPPEQAR 261
           +  E+T     S K  +S+E+T   DL P    + KP    ET   +T+      P+   
Sbjct: 299 DGKEKTT----SAKETQSIEKTSAKDLAPTSKVLAKPTPKAET---TTKGPALTTPK--- 348

Query: 262 LEFLEKEPRKSSEEAGLEPPEET---------------------QPEVPEEMQRKATEEK 300
               E  P    E A   P E T                      P  P+E     T+E 
Sbjct: 349 ----EPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP 404

Query: 301 GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPES 360
               P+   P     +P  +T ++ P   +E     P++ +  T +E      +   P +
Sbjct: 405 APTTPKEPAPT-TTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT 463

Query: 361 PEEIRKSNEKKNPQPPEETGPVLPQEINPQV-EEKTQTKPTEKILELPDETKPRETHVEF 419
           P+E   + ++  P  P+E  P  P++  P   +E   T P E     P  T  +E     
Sbjct: 464 PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE-----PAPTTTKEPSPTT 518

Query: 420 SKEDRPEPIKS 430
            KE  P   KS
Sbjct: 519 PKEPAPTTTKS 529


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 111/531 (20%), Positives = 220/531 (41%), Gaps = 78/531 (14%)

Query: 50   EIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKS 109
            E+ +  Q E  E+  K  EP+  +  QL      +E   ++ +R+     E    Q +K 
Sbjct: 606  EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE----QRLKR 661

Query: 110  ETSREMGEFFKDLEAPMDETHKESDL--EPPEEAKPNVTEDV-FLESAMETDPDPVPPTE 166
            E   E  E  + L+   +E  +E +L  E  E+A+  +   +   +  +E++ D      
Sbjct: 662  EEEEERLE--QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADA----- 714

Query: 167  TMSEVSGATVRERNLELLEEETEPGVPEES-LRVQHEETG--LEPPEQTKQDFP-----S 218
              S+V     ++      +E+ E     ES L+ Q EE     +  E+ ++DF       
Sbjct: 715  RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774

Query: 219  EKLGESLEETDLQPPKMTKPET---------------PEETQRESTEKKRTEPPEQARLE 263
            EK     +    +PP   + E                PEE ++E   ++R E   +  L+
Sbjct: 775  EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE--REKELQ 832

Query: 264  FLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDE 323
            FLE+E +    E   +  EE +  + E+ +R+ ++E+  +   R + +  + K R+ T  
Sbjct: 833  FLEEEEQLQRRERAQQLQEE-EDGLQEDQERRRSQEQRRDQKWRWQLE-EERKRRRHTLY 890

Query: 324  NVPEPLEEIKLE---FPEEES----------RKTNEETILEQSEMMKPESPEEIRKSNEK 370
              P   E+++ E     EEE           R+  +E    + E ++ E  + +R+  EK
Sbjct: 891  AKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950

Query: 371  KNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKS 430
            +  Q          +E   + ++K Q K  + + E P++ + +E   ++ +E+  +  + 
Sbjct: 951  RRRQ---------ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE 1001

Query: 431  KYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSE 490
            +        E RE +R       ++ ++Y     L++ EE +       + LQ+      
Sbjct: 1002 QLL-----REEREKRR-----RQEWERQYRKKDELQQEEEQLLREEREKRRLQE-----R 1046

Query: 491  ECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFE 541
            E  Y +  E Q E  + + E+      QEL+ +  +++E Q E+   L+ E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 87/396 (21%), Positives = 164/396 (41%), Gaps = 54/396 (13%)

Query: 177  RERNLELLEEETEPGVPEESLRVQHEETGLEPPEQ---TKQDFPSEKLGESLEETDLQPP 233
            RE+ L+ LEEE +    E + ++Q EE GL+  ++   +++    +K    LEE   +  
Sbjct: 827  REKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRR 886

Query: 234  KM--TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEE 291
                 KP   E+ ++E    ++    E+  L+  E+E R+  E+      EE   +  E+
Sbjct: 887  HTLYAKPALQEQLRKE----QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942

Query: 292  MQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE 351
            + R+  E++  +  ER          +   D+ + +  E++  E PE+  R+  E+   E
Sbjct: 943  LLREEREKRRRQERER----------QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992

Query: 352  QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETK 411
            + E+ + E  + +R+  EK+             QE   Q  +K + +  E+ L   +  K
Sbjct: 993  EEELQQ-EEEQLLREEREKRR-----------RQEWERQYRKKDELQQEEEQLLREEREK 1040

Query: 412  PRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEES 471
             R    E    +  E  + +  +  +E E R     +  L  ++RKE      L++ EE 
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRR----RQELERQYRKE----EELQQEEEQ 1092

Query: 472  IGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQ 531
            +       +  +K      E    +  E Q E  + + E+      QEL+ +  E++E Q
Sbjct: 1093 L-----LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147

Query: 532  ----------PEKGTELQFEHLNWDPEEVAEWISQL 557
                      PEK    + E    + EE+ +   QL
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 100/476 (21%), Positives = 188/476 (39%), Gaps = 40/476 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           Q+ + E EEE  ++      +  +LK     QE      KR+   ETE    +  K +  
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLK---REQEERRDWLKRE--EETERHEQERRKQQLK 477

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVS 172
           R+  E  ++    ++E  +    E  E+      E+   +     + +        SE  
Sbjct: 478 RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537

Query: 173 -GATVRERNLELLEEETEPGVPEES----LRVQHEETG---LEPPEQTKQDFPSEKLGES 224
                 ER  +LL+ E E  + +E     L+ + EE     L+  E+ +Q    ++L   
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ----QRLKRE 593

Query: 225 LEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEET 284
            EE   Q  K  + E  E+ +R     KR EP E+ R + L+ E ++   +  L   ++ 
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653

Query: 285 QPEVPEEMQRKATEEKGTELPERTKPDF-PDHKPRKSTDENVPEPLEEIKLEFPEEESRK 343
           + E     QR   EE+   L +R K +   + + ++  +E   +  E IK   P+ + + 
Sbjct: 654 RRE-----QRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQL 708

Query: 344 TNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKI 403
            +E    +     +P   E  R+  E++  +   E+      E+  Q EE+   +  E  
Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES------ELQWQEEERAHRQQQE-- 760

Query: 404 LELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALG 463
                E + R+   ++  E++ E  + + S      E RE    +L   ++ ++E   L 
Sbjct: 761 -----EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE---RQLRAEERQQREQRFLP 812

Query: 464 SLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQE 519
              E E+      E  + LQ  L   E+    + ++   E  + + E +    SQE
Sbjct: 813 EEEEKEQRRRQRREREKELQ-FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 84/480 (17%), Positives = 199/480 (41%), Gaps = 29/480 (6%)

Query: 56  QPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREM 115
           Q   +EED +  EP   + ++ +PG   ++   +E +R++    E    QE   +  R+ 
Sbjct: 111 QDRRQEEDQRRFEPRD-RQLEEEPGQRRRQK-RQEQERELAEGEEQSEKQERLEQRDRQR 168

Query: 116 G--EFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSG 173
              E ++  +   +   + ++ E  +  K + TE+ F +       + +       E   
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE-FPDEEQLRRRELLELRRKGREEKQ 227

Query: 174 ATVRERNLELLEEETEPG--VPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
              RER   + +EE E      E  LR + E+   E P++ ++    E+    LE  +L+
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEE 291
             +  + +  +  +RE   +++ E   +      ++E R+  +E      E+ +    ++
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERRE-----QQEERREQQER----REQQEERREQQ 338

Query: 292 MQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE 351
           ++R+  E +  +L    + +  + + R+  +E   E  ++++ E      ++   E  L 
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERRE--QQLRREQQLRREQQLRREQQLR 396

Query: 352 QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETK 411
           + + ++ E  +++R+  + +  Q       +  ++   + E+K + +  E+ L+   E +
Sbjct: 397 REQQLRRE--QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEER 454

Query: 412 PRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEES 471
            R+      + +R E  + K  +  D+ E R  +  KL   ++  ++      LR  +E 
Sbjct: 455 -RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513

Query: 472 IGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQ 531
                   +  Q+L    EE        S+ +L     E+    L +E ++R+ ++   Q
Sbjct: 514 --------RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 100/508 (19%), Positives = 196/508 (38%), Gaps = 65/508 (12%)

Query: 60  EEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFF 119
           EEE  +E EP   + +Q       +E + K  ++++  E      QE + +  R   E  
Sbjct: 256 EEEKLQEEEPQRQRELQ-----EEEEQLRKLERQELRRE-----RQEEEQQQQRLRRE-- 303

Query: 120 KDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRER 179
           + L    +E  +E   E  E+ +    ++   E  +  + +     +   E       ER
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE----EER 359

Query: 180 NLELLEEETEPGVPEESLRVQHE---------ETGLEPPEQTKQDFPSEKLGESLEETDL 230
             + L  E E    E+ LR + +         E  L   +Q +++    +  +   E  L
Sbjct: 360 REQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419

Query: 231 QPPKMTKPETPEETQRESTEKKRTEP----PEQARLEFL--EKEPRKSSEEAGLEPPEET 284
           +  +  + E  EE   +  E++R E      ++ R ++L  E+E  +  +E   +  +  
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479

Query: 285 QPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKT 344
           Q E   E   K  EE+  E  ER      + + R+  +E       E +L+  EEE R  
Sbjct: 480 QEEERRERWLKLEEEERREQQERR-----EQQLRREQEER-----REQRLKRQEEEERLQ 529

Query: 345 NEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKIL 404
                 +Q    + E  E++ K  E+K           L QE   Q  ++ Q +  +++L
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKR----------LEQERREQRLKREQEERRDQLL 579

Query: 405 ELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGS 464
           +  +E   R+  ++  +E+R E    +  V   E E R  +R K    ++ R++      
Sbjct: 580 KREEER--RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637

Query: 465 LRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERV 524
            +E         E  +  ++ L   EE       E   +  +  HE+E        ++ +
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEE------EERLEQRLKREHEEE------RREQEL 685

Query: 525 SEDDETQPEKGTELQFEHLNWDPEEVAE 552
           +E+++ Q  +  + +     W  E  A+
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEAD 713



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 70/370 (18%), Positives = 157/370 (42%), Gaps = 34/370 (9%)

Query: 198 RVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPP 257
           R + ++   EP ++  ++ P ++  +  +E + +  +  +    +E   +   ++R E  
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173

Query: 258 EQARLEFLEKEPRKSSEE--------AGLEPPEETQPEVPE--EMQRKATEEKGTELPER 307
            + R E+ E+E R++ EE           E P+E Q    E  E++RK  EEK  +  ER
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233

Query: 308 TKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKS 367
               F + + ++          EE KL+  EEE ++  E  + E+ E ++    +E+R+ 
Sbjct: 234 QDRVFQEEEEKEWRKRETVLRKEEEKLQ--EEEPQRQRE--LQEEEEQLRKLERQELRRE 289

Query: 368 NEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEP 427
            +++             Q+   + E++ + K  E+  E  +E + ++   E  +E R + 
Sbjct: 290 RQEEE-----------QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338

Query: 428 IKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLN 487
           ++        E E R  ++ +    ++ R++        E  E      + L+  Q+L  
Sbjct: 339 LRR-------EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391

Query: 488 VSE-ECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWD 546
             +         E Q    + +  ++ +   Q+L+ R  E++  + +   E + + L  +
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQEEERHEQKHEQERREQRLKRE 450

Query: 547 PEEVAEWISQ 556
            EE  +W+ +
Sbjct: 451 QEERRDWLKR 460



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 90/436 (20%), Positives = 176/436 (40%), Gaps = 44/436 (10%)

Query: 14   EDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAK 73
            E+ EL+ E  +L G        E +T  + +  L  +  +E + + EEE     EP+  +
Sbjct: 1052 EEEELQQEEEQLLG-------EERETRRRQE--LERQYRKEEELQQEEEQLLREEPEKRR 1102

Query: 74   NVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVK------SETSREMGEFFKDLEAPMD 127
              + +     +E + +E ++ +  E E    QE++       E  +E  +  +  E P  
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR--EEPEK 1160

Query: 128  ETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEE 187
               +E + +  EE +    E+  L    E         E          R++  +   +E
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQE---RERQYREEEELQRQKRKQRYRDE 1217

Query: 188  TEPG------VPEESLRVQHEETGLEPPEQTK-QDFPSEKLGESLEETDLQPPKMTKPET 240
             +         PE+   V+  +   +  E  + +     +L +   + DLQ     + E 
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277

Query: 241  PEETQRESTEKKRTEPPEQARLEFLE-----KEPRKSSEEAGLEPPEETQPEVPEEMQRK 295
              E +R   +++    PE+ +LE  E     +  RKS EE  L   E  +    +E  RK
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337

Query: 296  ATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEET----ILE 351
              EE+        +P     + RK  +E +    +E   +F EEE R   +E     + E
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRH--QEQGRKFLEEEQRLRRQERERKFLKE 1395

Query: 352  QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQV-EEKTQTKPTEKILELPDET 410
            + ++   E  +++R+  ++K     EE   +  QE + +  EE+ Q +  E+  +  +E 
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKF---REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452

Query: 411  KP--RETHVEFSKEDR 424
            +   +E H +F +E++
Sbjct: 1453 QQLRQERHRKFREEEQ 1468



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 108/521 (20%), Positives = 204/521 (39%), Gaps = 79/521 (15%)

Query: 34   NAEPDTMAKADSKLPAEIYQEPQ----PETEEEDFKEGEP-DSAKNVQLKPGGTSQEGIA 88
            +A P    + + +L AE  Q+ +    PE EE++ +  +  +  K +Q       +E + 
Sbjct: 785  SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE---EEEQLQ 841

Query: 89   KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTED 148
            +  +     E E G+ ++ +   S+E     K     ++E  K         AKP + E 
Sbjct: 842  RRERAQQLQEEEDGLQEDQERRRSQEQRRDQK-WRWQLEEERKRR--RHTLYAKPALQEQ 898

Query: 149  VFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEP 208
            +  E  +                    ++E   EL  EE E    +E  R   EE  L+ 
Sbjct: 899  LRKEQQL--------------------LQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938

Query: 209  PEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKE 268
             E+       EK      E   +  K  + +  E+   E  EK+R +  E+   ++ E+E
Sbjct: 939  EEEQLLREEREKRRRQERERQYRKDKKLQ-QKEEQLLGEEPEKRRRQEREK---KYREEE 994

Query: 269  PRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEP 328
              +  EE  L   EE +    +E +R+    K  EL +  +    + + ++   E   + 
Sbjct: 995  ELQQEEEQLLR--EEREKRRRQEWERQY--RKKDELQQEEEQLLREEREKRRLQERERQY 1050

Query: 329  LEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEIN 388
             EE +L+  EE+      ET   Q    +    EE+++  E+   + PE+      QE  
Sbjct: 1051 REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR---RRQERE 1107

Query: 389  PQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGK 448
             Q  E+ + +  E+ L   +  K R   +E    +  E  + +  +  +E E    KR +
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE----KRRR 1163

Query: 449  LSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFV 508
              L  ++R+E      L++ EE      + L+  Q+      E  Y +  E Q       
Sbjct: 1164 QELERQYREE----EELQQEEE------QLLREEQEKRRQERERQYREEEELQ------- 1206

Query: 509  HEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEE 549
                     Q+ K+R  ++D+      ++L+++   W+PE+
Sbjct: 1207 --------RQKRKQRYRDEDQR-----SDLKWQ---WEPEK 1231



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 108/560 (19%), Positives = 210/560 (37%), Gaps = 79/560 (14%)

Query: 14   EDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAK 73
            E+ EL+ E  +L     L E  E     +   +L  +  +E + + EEE     EP+  +
Sbjct: 1112 EEEELQQEEEQL-----LREEREK----RRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162

Query: 74   NVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKES 133
              +L+     +E + +E ++ +  E E    +  +     E  +  K  +   DE  +  
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222

Query: 134  DLEPPEEAKPNVTED--VFLESAMETDPDPVPPTETMSEVSGATVRERNLE-----LLEE 186
                 E  K N   D  V+ +             E   ++  + +R+R  +     LL E
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGR---------ENEQFRQLEDSQLRDRQSQQDLQHLLGE 1273

Query: 187  ETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQR 246
            + E    +E  R Q  +      EQ +++   +K  +  +    +  ++ + E  E+ +R
Sbjct: 1274 QQERDREQERRRWQQRDRHFPEEEQLERE--EQKEAKRRDRKSQEEKQLLREEREEKRRR 1331

Query: 247  ESTEKK----------RTEPP------------------EQARLEFLEKEPRKSSEEAGL 278
            + T++K          R E P                  EQ R +FLE+E R   +E   
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGR-KFLEEEQRLRRQERER 1390

Query: 279  EPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPE 338
            +  +E Q    +E +++  +++  +  E  +      + RK  +E      +E + +F E
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450

Query: 339  EESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTK 398
            EE +       L Q    K    E++ +  E++     E     L +E   + +E+ +  
Sbjct: 1451 EEQQ-------LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503

Query: 399  PTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKE 458
              +++     E K  E   +  ++ R            +E + R  +RG+    D+ RK 
Sbjct: 1504 REQELRSQEPERKFLEEEQQLHRQQRQRKFL------QEEQQLRRQERGQQRRQDRDRKF 1557

Query: 459  YYALGSLRESEESIGTHYE----FLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVV 514
                   +E EE   +  E    F    QK+    +E  + +  E Q    E   +    
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFME-DEQQLRRQEGQQQ---- 1612

Query: 515  DLSQELKERVSEDDETQPEK 534
             L QE   +  ED++   E+
Sbjct: 1613 -LRQERDRKFREDEQLLQER 1631



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 49/222 (22%), Positives = 96/222 (43%), Gaps = 7/222 (3%)

Query: 182  ELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETP 241
            +LL+E  E    ++  R + +   LE   Q ++    ++L    +    +  ++ +    
Sbjct: 1626 QLLQEREE----QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 242  EETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKG 301
            ++ +R+  ++K  E  +Q R +  E+E +   EE  L   E  +    EE  R+ TE++ 
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQ--ERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQ 1739

Query: 302  TELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEM-MKPES 360
                ER +    + + R   +E      E  +    EE+ R+  EE  L   E   K   
Sbjct: 1740 LRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799

Query: 361  PEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEK 402
             E++R+  E++  +P +  G    +E   Q+EE+ Q    E+
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER 1841



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 70/334 (20%), Positives = 124/334 (37%), Gaps = 26/334 (7%)

Query: 53   QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
            ++ + E EE+     E D    ++       Q+   +E +R    + +    QE + +  
Sbjct: 1561 EQLRQEREEQQLSRQERDRKFRLE------EQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614

Query: 113  REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFL-----ESAMETDPDPVPPTET 167
            +E    F++ E  + E  +E  L   E  +  + E+  L     E  +  D D     E 
Sbjct: 1615 QERDRKFREDEQLLQE-REEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673

Query: 168  M----SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGE 223
                  E      +ER+ +  EEE +    E   +   EE  L   E  ++    E+L +
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733

Query: 224  SLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEE 283
              E+  L+          +E  R+  E+++  P  + +    ++  RK  EE  L    E
Sbjct: 1734 ETEQEQLRR---------QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784

Query: 284  TQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRK 343
             Q    +E  RK  EE+        +   P  +  K   E     LEE +    +E  R+
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844

Query: 344  TNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE 377
               E      E  + E  +E+ +  E+K  Q  E
Sbjct: 1845 YRAEEQFATQEKSRREE-QELWQEEEQKRRQERE 1877



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 60/305 (19%), Positives = 129/305 (42%), Gaps = 23/305 (7%)

Query: 243 ETQRESTEKKRTEPPEQARLEFLEKEP----RKSSEEAGLEPPE-ETQPEVPEEMQRKAT 297
           + +R+  +++R EP ++     LE+EP    R+  +E   E  E E Q E  E ++++  
Sbjct: 111 QDRRQEEDQRRFEPRDRQ----LEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166

Query: 298 EEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMK 357
           + +  EL  R + ++ + + R++ +E +         EFP+EE  +  E  +LE     +
Sbjct: 167 QRRDEEL-WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE--LLELRRKGR 223

Query: 358 PESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKP-RETH 416
            E  ++ R+  + +  Q  EE      + +  + EEK Q +  ++  EL +E +  R+  
Sbjct: 224 EEKQQQ-RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 417 VEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHY 476
            +  + +R E  + +  +  ++   R+ +  +    ++ R++        E  E      
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE------ 336

Query: 477 EFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGT 536
              Q L++      E       E +    +   E+E     Q+L+       E Q  +  
Sbjct: 337 ---QQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393

Query: 537 ELQFE 541
           +L+ E
Sbjct: 394 QLRRE 398



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 78/405 (19%), Positives = 144/405 (35%), Gaps = 24/405 (5%)

Query: 19   EPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLK 78
            EPER  L    +L+         + + +L  +   + + +  +  F+E E       QL+
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE-------QLR 1564

Query: 79   PGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPP 138
                 Q+   +E  R    E +    QE + +        F + E  +     +  L   
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERK--------FMEDEQQLRRQEGQQQLRQE 1616

Query: 139  EEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLR 198
             + K    E +  E   +         + + E      +ER  +L  +       EE L 
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLL 1676

Query: 199  VQHEETGLEPPEQTKQDFPSEKL--GESLEETDLQPPKMTKPETPEETQRESTEKKRTEP 256
             + EE  L   E+ ++    E+    +  E   LQ  +  + +  E   RE  + ++   
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETE 1736

Query: 257  PEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHK 316
             EQ R +   +  RK  EE  L P  E Q    +E  RK  EE+        +       
Sbjct: 1737 QEQLRRQ---ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQES 1793

Query: 317  PRK-STDENVPEPLEEIKLEFPEEESRKTNEETIL---EQSEMMKPESPEEIRKSNEKKN 372
             RK   +E + +  EE +L   + + +   EE  L   EQ + ++ E   + R   +   
Sbjct: 1794 DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFAT 1853

Query: 373  PQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHV 417
             +        L QE   +  ++ + K  E+ +    + + R   V
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 97/409 (23%), Positives = 181/409 (44%), Gaps = 46/409 (11%)

Query: 161 PVPPTETMSEV--SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPS 218
           P  P E +  V   G + +   LE LE+       ++ L  Q + TG  P    KQ    
Sbjct: 477 PANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQT--- 533

Query: 219 EKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGL 278
            KL +  +  +   P   KP   +  ++ES E    E PE  ++  +EK P+  S+E  +
Sbjct: 534 -KLKQRADSRESLKPA-AKPLPSKSVRKESKE----ETPEVTKVNHVEKPPKVESKEKVM 587

Query: 279 EPPE-----ETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENV-------P 326
              +     ET+P V E+ +  + EE      E  +    D KP+ + ++ V       P
Sbjct: 588 VKKDKPIKTETKPSVTEK-EVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKP 646

Query: 327 EPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP--EETGPVLP 384
           E  +E K +  +E ++K ++  I ++ +  K E  +E++K  +K+  + P  E      P
Sbjct: 647 EDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706

Query: 385 QEINPQV--EEKTQTK-----PTEKILELPDETKPRETHVEFSKED---RPEPIKSKYSV 434
           +E+  +V  EEK + K     P ++I +LP + K   T +  +K+    +P+  K + SV
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESV 766

Query: 435 GNDELEHREPK-RGKLSLSDKFRKEYYALGS-----LRESEESIGTHYEFLQPLQKLLNV 488
             D +   +PK +GK+ +  K  K   A+ +        +          + P ++L   
Sbjct: 767 KKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKEL--E 824

Query: 489 SEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTE 537
           +E    S P +   +  E   + E VD+++++K ++   ++ +  K TE
Sbjct: 825 AERSLMSSPEDLTKDFEEL--KAEEVDVTKDIKPQLELIEDEEKLKETE 871



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 108/541 (19%), Positives = 215/541 (39%), Gaps = 78/541 (14%)

Query: 53   QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
            Q P P  ++   K+   DS ++++        + + KESK + P  T+    ++     S
Sbjct: 524  QVPTPVVKQTKLKQ-RADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVES 582

Query: 113  REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVS 172
            +E     KD     +     ++ E P + +P+  +    E    TD  P    E      
Sbjct: 583  KEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEK-QATDVKPKAAKEK----- 636

Query: 173  GATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQP 232
                +E  ++  +++ E   P++ +  + ++T ++  E+ K++   +++ + +++ + + 
Sbjct: 637  -TVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKE 695

Query: 233  PKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEM 292
            PK               E K+  PP++ + E ++KE +K  ++   EP +E + ++P++ 
Sbjct: 696  PK--------------KEVKKETPPKEVKKE-VKKEEKKEVKKEEKEPKKEIK-KLPKDA 739

Query: 293  QRKATEEKGTELPERTKPDFPDHKPRKSTDE-NVPEPLEEIKLEFPEEESRKTN------ 345
            ++ +T     + P   KP  P  +     D     +P E+ K++  ++E +         
Sbjct: 740  KKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAV 799

Query: 346  ---------------------EETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLP 384
                                 +E   E+S M    SPE++ K  E+   +  + T  + P
Sbjct: 800  GTGATTAAVMAAAGIAAIGPAKELEAERSLM---SSPEDLTKDFEELKAEEVDVTKDIKP 856

Query: 385  Q-EINPQVEEKTQTKPTEKIL------------ELPDETKPRETHVEFSKEDRPEPIKSK 431
            Q E+    E+  +T+P E  +            E PDE     T  E   E  PE ++  
Sbjct: 857  QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDE-GITTTEGEGECEQTPEELEPV 915

Query: 432  YSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEE 491
               G D++E  E +      S +   +Y       E+EE      E +      ++ S+ 
Sbjct: 916  EKQGVDDIEKFEDEGAGFEESSE-TGDYEEKAETEEAEEPEEDGEEHV-----CVSASKH 969

Query: 492  CSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVA 551
                D   ++ E   ++ EK     S +  +R  ED +   EKG   Q E    D E+ A
Sbjct: 970  SPTEDEESAKAEADAYIREKRESVASGD--DRAEEDMDEAIEKGEAEQSEE-EADEEDKA 1026

Query: 552  E 552
            E
Sbjct: 1027 E 1027



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 122/588 (20%), Positives = 206/588 (35%), Gaps = 74/588 (12%)

Query: 2    AEVPEDYDSGPDEDGELEPERPELPGLHKL----YENAEPDTMAKADSKLPAEIYQEPQP 57
            AE P++  +  + +GE E    EL  + K      E  E +     +S    +  ++ + 
Sbjct: 889  AESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAET 948

Query: 58   ETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGE 117
            E  EE  ++GE     +         +E    E+   +  + E     + ++E   +M E
Sbjct: 949  EEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAE--EDMDE 1006

Query: 118  FFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGA--- 174
              +  EA  +++ +E+D E   E   +  E+ +    ME +   +   +  +E  GA   
Sbjct: 1007 AIEKGEA--EQSEEEADEEDKAE---DAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQ 1061

Query: 175  ----TVRERNLELLEEETEPG--VPEESLRVQHEETGLEPPEQTKQDFPSEKLG-----E 223
                T   + L       EP   + +E+L    E       E+ ++D P E        +
Sbjct: 1062 YGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQ 1121

Query: 224  SLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEE 283
            S  E   +P  M +  TP +   + T  + TE P Q  +   + E    S+E     P +
Sbjct: 1122 STIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQE--YSKPAD 1179

Query: 284  TQP--EVPEEMQRKATEEKGTELPERT---KPDFPDHKPRKST--DENVPEPLEEIKLEF 336
              P     E  +  AT+ K       T        + K  +S   D    E      L+ 
Sbjct: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239

Query: 337  PEEESRKTNEETILEQSEMMKPESPEEIRKS-------------NEKKNPQPPEETGPVL 383
             +  S  ++E+    +S  + P  P  + K+             NE K      E  PV 
Sbjct: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIK-VSAEAEVAPVS 1298

Query: 384  PQEINPQVEEKTQTKPTEKILEL-------------------PDETKPRETHVEFSKEDR 424
            P E+  +V E+    P +K LE+                   P + K      E  ++  
Sbjct: 1299 P-EVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPP 1357

Query: 425  PEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTH--YE-FLQP 481
              P+  ++S   DE E          + D        L  LR S   IG+   YE FL  
Sbjct: 1358 AVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLR-SPPLIGSESAYESFLSA 1416

Query: 482  LQKLLNVSEECSYSDPSESQTELSEF--VHEKEVVDLSQELKERVSED 527
              K      E  + + S  Q    +   V E     L Q+ +E  S D
Sbjct: 1417 DDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTD 1464



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 88/449 (19%), Positives = 173/449 (38%), Gaps = 38/449 (8%)

Query: 3    EVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEE 62
            EVP   +  P +    E +  ++       +  + +T  K + K   E  ++P+ E  ++
Sbjct: 606  EVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDK--KEEKEKPKKEVAKK 663

Query: 63   D----FKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPG-IHQEVKSETSREMGE 117
            +     K+ E    + V+ +     ++   KE K++V  ET P  + +EVK E  +E+ +
Sbjct: 664  EDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKK 723

Query: 118  FFKDLEAPMDETHKE--------SDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMS 169
              K+ +  + +  K+        S+ + P   KP V +    E +++ D       +   
Sbjct: 724  EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK---EESVKKDSVAAGKPKEKG 780

Query: 170  EVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQD----FPSEKLGESL 225
            ++       +  E +      G    ++        + P ++ + +       E L +  
Sbjct: 781  KIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDF 840

Query: 226  EETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQ 285
            EE   +   +TK   P+    E  EK +   P +A +   E+E  K   E+  E    T+
Sbjct: 841  EELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTE 900

Query: 286  PE-----VPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEE 340
             E      PEE++    E++G +  E+ + +    +    T +   E  E  + E PEE+
Sbjct: 901  GEGECEQTPEELE--PVEKQGVDDIEKFEDEGAGFEESSETGD-YEEKAETEEAEEPEED 957

Query: 341  SRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPT 400
                 EE +   +    P   EE  K+      +   E+           ++E  +    
Sbjct: 958  ----GEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEA 1013

Query: 401  EKILELPDETKPRETHVEFSKEDRPEPIK 429
            E+  E  DE    E   E ++E+  EP K
Sbjct: 1014 EQSEEEADE----EDKAEDAREEEYEPEK 1038



 Score = 36.2 bits (82), Expect = 0.10
 Identities = 64/318 (20%), Positives = 113/318 (35%), Gaps = 74/318 (23%)

Query: 132  ESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPG 191
            +SD+ P  E  P++T D  ++S  E++  P   T T   +              +     
Sbjct: 2159 DSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHM--------------DPPPAP 2204

Query: 192  VPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEK 251
            V + S   +H +  +  PE    +   + LG++L++   +  K  KP T  +T+  S  K
Sbjct: 2205 VQDRSPSPRHPDVSMVDPEALAIE---QNLGKALKKDLKEKTKTKKPGT--KTKSSSPVK 2259

Query: 252  KRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPD 311
            K          +   K    S + AGL+       E  +++ R A+ +K   + +  K  
Sbjct: 2260 KS---------DGKSKPLAASPKPAGLK-------ESSDKVSRVASPKKKESVEKAAK-- 2301

Query: 312  FPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKK 371
                          P    E+K    EE+ ++T        S+  K  +         K 
Sbjct: 2302 --------------PTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKS 2347

Query: 372  NPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSK 431
            +  PP      LP  ++              +  +P+ +  +   VEF K  R     S 
Sbjct: 2348 SAVPPG-----LPVYLD--------------LCYIPNHSNSKNVDVEFFKRVR----SSY 2384

Query: 432  YSVGNDELEHREPKRGKL 449
            Y V  ++    EP R  L
Sbjct: 2385 YVVSGNDPAAEEPSRAVL 2402



 Score = 34.3 bits (77), Expect = 0.39
 Identities = 50/245 (20%), Positives = 79/245 (32%), Gaps = 38/245 (15%)

Query: 85   EGIAKESKRDVPS---------ETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDL 135
            EG+A  S   V +         +  P +H EV S  S E+ +           T +E+++
Sbjct: 1547 EGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEM 1606

Query: 136  EPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVR------ERNLELLEEETE 189
             P +E  P        + + +T     P  +  SE S  ++       E++L +      
Sbjct: 1607 SPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQS 1666

Query: 190  PGVPEESLRVQH-EETG----------------------LEPPEQTKQDFPSEKLGESLE 226
            P  P     V H  E G                      +E P  T+ +  SE +  S  
Sbjct: 1667 PDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQV 1726

Query: 227  ETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQP 286
            E          P       +E T      P + +    L  E  +S E   L P  +  P
Sbjct: 1727 EASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDISP 1786

Query: 287  EVPEE 291
              P E
Sbjct: 1787 LTPRE 1791



 Score = 33.5 bits (75), Expect = 0.66
 Identities = 79/387 (20%), Positives = 130/387 (33%), Gaps = 60/387 (15%)

Query: 101  PGIHQEVKSETSREMGEFFKDLEAPMDETHK--ESDLEPPEEAKPNVTEDV---FLESAM 155
            PG+ ++   +T    G+F    + P + T    E D +     K   T DV   + E   
Sbjct: 1854 PGLEKDSGGKTP---GDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSDVGGYYYEKIE 1910

Query: 156  ETDPDPVPPTETMSEVSGATVR----ERNLELLEEETEPGVPEES-LRVQHEETGLEPPE 210
             T   P     +   +   T      + + E++E+ T    PEE        E    PPE
Sbjct: 1911 RTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTR--TPEEGGYSYDISEKTTSPPE 1968

Query: 211  QTKQDFP------------------SEKLGESLEETDLQPPKMTK----PETPEETQRES 248
             +   +                   SE  G +L +         K    PE+   +   S
Sbjct: 1969 VSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITSFPESEGYSYETS 2028

Query: 249  TEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERT 308
            T+  RT        E  EK  R  + +A     E +      E +  +   +  +L   +
Sbjct: 2029 TKTTRTPDTSTYCYETAEKITR--TPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVS 2086

Query: 309  KPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEET-----------ILEQSEMMK 357
              ++   K   S     P PLE    E P EES K   ++              Q +   
Sbjct: 2087 SCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETP 2146

Query: 358  PESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELP---------D 408
            P S  E   S    +  P  E  P +  + N   E++++T PT+K +             
Sbjct: 2147 PTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDKTVTYKHMDPPPAPVQ 2206

Query: 409  ETKPRETHVEFSKEDRPEPIKSKYSVG 435
            +  P   H + S  D PE +  + ++G
Sbjct: 2207 DRSPSPRHPDVSMVD-PEALAIEQNLG 2232



 Score = 30.8 bits (68), Expect = 4.3
 Identities = 50/239 (20%), Positives = 81/239 (33%), Gaps = 33/239 (13%)

Query: 37   PDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVP 96
            P+ +    S+ P E  ++P  ++       G     +     P  +  E    ++  DVP
Sbjct: 2104 PNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVP 2163

Query: 97   SETE--PGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESA 154
             ETE  P I  +   ++  E          P D+T     ++PP    P   +D    S 
Sbjct: 2164 PETEECPSITADANIDSEDESETI------PTDKTVTYKHMDPP----PAPVQD-RSPSP 2212

Query: 155  METDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEES-------------LRVQH 201
               D   V P     E +     +++L+   +  +PG   +S             L    
Sbjct: 2213 RHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASP 2272

Query: 202  EETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQA 260
            +  GL+          S K  ES+E       K  KP T  E +    E+K  E    A
Sbjct: 2273 KPAGLKESSDKVSRVASPKKKESVE-------KAAKPTTTPEVKAARGEEKDKETKNAA 2324


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 116/449 (25%), Positives = 171/449 (38%), Gaps = 68/449 (15%)

Query: 17  ELEPERPELPGLHKLYENAEP----DTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSA 72
           E+EP     P   K     +P    +  AKA+ +   E + + QP TEE    E     A
Sbjct: 256 EIEP-----PSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVA 310

Query: 73  KN-VQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHK 131
           +N V+++P    +  + +      P   E     E+ +E      E     E+P +E   
Sbjct: 311 ENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAE-----ESPSEEPPA 365

Query: 132 ESDLEPPEEAKPNV--TEDVFLESAMETDPDPVP-PTETMSEVSGATVRERNLELLEEET 188
           E  L PP E  P+V    ++   SA +   +  P P E   E + A V    +E    + 
Sbjct: 366 EI-LPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADV 424

Query: 189 EPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRE- 247
           +P +PEE+ R +  E  L     T  + P+E+       T+ Q P + K  T EE   E 
Sbjct: 425 QPLLPEEAPREEARELQL----STAMETPAEE-----APTEFQSP-LPKETTAEEASAEI 474

Query: 248 ----STEKKRTEPPEQARLEFLEKEPRKSSEEAGLE-----PPEETQPEVPEEMQ-RKAT 297
               +TE    E P +AR    E+    S+EEA  E       E T  E   E+Q   A 
Sbjct: 475 QLLAATEPPADETPAEARSPLSEE---TSAEEAHAEVQSPLAEETTAEEASAEIQLLAAI 531

Query: 298 EEKGTELPERTKPDFPDHKPRKSTDENVPEP------LEEIKLEFPEEESRKTNEE---- 347
           E    E P   +    +    +     V  P      +EE  LE       +T  E    
Sbjct: 532 EAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASA 591

Query: 348 --TILEQSEMMKPESPEEIRKSNEKKNP----QPPEETGPVLPQEINPQVEE---KTQTK 398
              +L  +E    E+P E++    ++ P     PP E  P   Q   P  EE   + Q  
Sbjct: 592 AIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP--PPAEEAPAEVQPP 649

Query: 399 PTEKILELPDETKPRETHVEFSKEDRPEP 427
           P E   E P E +P     E   E +P P
Sbjct: 650 PAE---EAPAEVQPPPAE-EAPAEVQPPP 674



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 110/440 (25%), Positives = 167/440 (37%), Gaps = 66/440 (15%)

Query: 1   MAEV-PEDYDSGPDEDGELE---PERPELPGLHKLYENAEPDTMAKADSK---LPAE--I 51
           +AE+ P   +  P E+   E   P   + P +  L E   P    KA  +   LPAE  +
Sbjct: 347 LAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQ-KAPIEVQPLPAEGAL 405

Query: 52  YQEP---QPETEEEDFKEGEP--------DSAKNVQLKPGGTSQEGIAKESKRDVPSETE 100
            + P   +P T EE   + +P        + A+ +QL    T+ E  A+E+    P+E +
Sbjct: 406 EEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLS---TAMETPAEEA----PTEFQ 458

Query: 101 PGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPD 160
             + +E  +E +    +     E P DET        P EA+  ++E+   E A      
Sbjct: 459 SPLPKETTAEEASAEIQLLAATEPPADET--------PAEARSPLSEETSAEEAHAEVQS 510

Query: 161 PVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEK 220
           P+    T  E S        +E   +ET    P E+     EET  E      Q  PS K
Sbjct: 511 PLAEETTAEEASAEIQLLAAIEAPADET----PAEAQSPLSEETSAEEAPAEVQS-PSAK 565

Query: 221 LGESLEET--DLQPPKMTKPETPEETQR----ESTEKKRTEPPEQARLEFLEKEPRKSSE 274
            G S+EE   +LQPP   +    E +       +TE    E P + +    E+ P +   
Sbjct: 566 -GVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQP 624

Query: 275 EAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKL 334
               E P E QP   EE   +       E P   +P   +  P     E  P P EE   
Sbjct: 625 PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA----EVQPPPAEEAPA 680

Query: 335 EFPEEESRKTN-EETI------------LEQSEMMKPESPEEIRKSNEKKNPQPPEETGP 381
           E     + +T  EET+             E++ + K   P ++  + E    +   E  P
Sbjct: 681 EVQSLPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEEFPIGEASAEVSP 740

Query: 382 VLPQEINPQVEEKTQTKPTE 401
             P E  P+ E   +   TE
Sbjct: 741 P-PSEQTPEDEALVENVSTE 759



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 109/529 (20%), Positives = 181/529 (34%), Gaps = 79/529 (14%)

Query: 57  PETEEEDFKEGE---PDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSR 113
           PE +  D +E     P+S ++V++ P   S +     S++   +     ++     +  +
Sbjct: 94  PEEKSADVREAAIELPESVQDVEIPPNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDK 153

Query: 114 EMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSG 173
           E   +F + E  +      S  +  E+A  + +      S     P+  P T +  E+  
Sbjct: 154 EQQTYFSESEIVVISRPDSSSTKSKEDALKHKSSGKIFASE---HPEFQPATNSNEEIGQ 210

Query: 174 ATVRERNL--------------ELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSE 219
             +   +               EL EE T P V E S   +     +EPP   K  FP++
Sbjct: 211 KNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPPSTEK--FPAK 268

Query: 220 KLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLE 279
                +EE   +       ET  + Q  + E    E         ++ +P  + E   +E
Sbjct: 269 IQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVE 328

Query: 280 PPEETQPEVPEE----------MQRKATEEKGTELPERTKPDFPDHKP------------ 317
            P E QP   EE          +   A E    E P    P   +  P            
Sbjct: 329 FPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPS 388

Query: 318 -RKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP 376
            +K+  E  P P E    E P +    T EET+ +   ++  E+P E  +          
Sbjct: 389 AQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARE--------- 439

Query: 377 EETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGN 436
                    +++  +E   +  PTE    LP ET   E   E       EP         
Sbjct: 440 --------LQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEP-----PADE 486

Query: 437 DELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSD 496
              E R P   + S  +   +    L     +EE+            +LL   E  +   
Sbjct: 487 TPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAE--------IQLLAAIEAPADET 538

Query: 497 PSESQTELSEFVHEKEV-VDLSQELKERVSEDD---ETQPEKGTELQFE 541
           P+E+Q+ LSE    +E   ++     + VS ++   E QP  G E   E
Sbjct: 539 PAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAE 587


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 111/462 (24%), Positives = 185/462 (40%), Gaps = 70/462 (15%)

Query: 14  EDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDS-- 71
           E+ E EPE  E           E     K+  K  A   +E + E EEE+ +E E +   
Sbjct: 493 EEKEEEPEAEE-----------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541

Query: 72  -AKNVQLKPGGTSQEGIA-KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDET 129
            AK+ Q + GG+ +EG + KE       ETE     E       +  E   +  A  +E 
Sbjct: 542 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601

Query: 130 HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETE 189
             ++ +E PE+AK  V +        E    PVP +                  +EE+ +
Sbjct: 602 VADAKVEKPEKAKSPVPKS----PVEEKGKSPVPKSP-----------------VEEKGK 640

Query: 190 PGVPEESLRVQHEETGLEP-PEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRES 248
             VP+  +    EE G  P P+   ++     + +S  E   + P    P++P E  +  
Sbjct: 641 SPVPKSPV----EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV---PKSPVEEAKSK 693

Query: 249 TEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKA--TEEKGTELPE 306
            E  + E  E+      EKE +++ +E  +E  EE   +VPE+ + ++   EE   E+  
Sbjct: 694 AEVGKGEQKEEE-----EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 748

Query: 307 RTKPDFPDHKPRKSTDENVPEPLEEIK----------LEFPEEESRKTNEETILEQSEMM 356
            TK     H  +++ +E  P   E+ K           E  ++ ++ + +E I    E+ 
Sbjct: 749 ITK-SVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV- 806

Query: 357 KPESPEEIRKSNEKKNPQPPEETGPVL-PQEINPQVEEKTQTKPTEKILELPDETKPRET 415
             E  EE+ +  ++K     EE G V    +++P  E+K   K  EK++     TK  E 
Sbjct: 807 --EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVV----VTKTVEK 860

Query: 416 HVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRK 457
                 +   + I    +V     EH E    KL  + K  K
Sbjct: 861 ITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 120/538 (22%), Positives = 210/538 (39%), Gaps = 68/538 (12%)

Query: 24  ELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTS 83
           E+    KL E  E      A S +   +Y    P T     ++ + ++ K   LK     
Sbjct: 397 EIAAYRKLLEGEETRFSTFAGS-ITGPLYTHRPPITISSKIQKPKVEAPK---LKVQHKF 452

Query: 84  QEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKP 143
            E I +E+K +           + KSE    +    ++L   M E  KE+  E  EE  P
Sbjct: 453 VEEIIEETKVE-----------DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE--P 499

Query: 144 NVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE 203
              E+   E A +  P      E + E  G    E   E  EEE E    +++     E+
Sbjct: 500 EAEEE---EVAAKKSPVKATAPE-VKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555

Query: 204 TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE-ETQRESTEKKRTEPPEQARL 262
            G    E+ +Q+    +     EE + +  K  + ++ E  T+ E     + E PE+A+ 
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK- 614

Query: 263 EFLEKEPRKSSEEAGLEP----PEETQPEVPEEMQRKATEEKG------TELPERTKPDF 312
                 P+   EE G  P    P E + + P  + +   EEKG      + + E+ K   
Sbjct: 615 ---SPVPKSPVEEKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKSPVPKSPVEEKGKSPV 669

Query: 313 PDHKPRKSTDENVPE-PLEEIKLEF------PEEESRKTNEETILEQSEMMKPESPEEIR 365
                 +     VP+ P+EE K +        +EE  K  +E   E+    K E P+++ 
Sbjct: 670 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 729

Query: 366 KSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRP 425
           +  + ++P   E    V+    + +V  + +TK   K L+   E +  +   E   E+  
Sbjct: 730 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ--QEKEKEKAGGEGGSEEEG 787

Query: 426 EPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKL 485
               +K S   D   +     G++   ++  +E    GS RE E+ + T+   L P    
Sbjct: 788 SDKGAKGSRKEDIAVN-----GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP---- 838

Query: 486 LNVSEECSYSDPSESQTELSEFVHE---------KEVVDLSQELKERVSEDDETQPEK 534
              ++E    D SE +  +++ V +          + +  S  + ++V E +ET  EK
Sbjct: 839 ---ADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 893


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 111/462 (24%), Positives = 185/462 (40%), Gaps = 70/462 (15%)

Query: 14  EDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDS-- 71
           E+ E EPE  E           E     K+  K  A   +E + E EEE+ +E E +   
Sbjct: 117 EEKEEEPEAEE-----------EEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165

Query: 72  -AKNVQLKPGGTSQEGIA-KESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDET 129
            AK+ Q + GG+ +EG + KE       ETE     E       +  E   +  A  +E 
Sbjct: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225

Query: 130 HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETE 189
             ++ +E PE+AK  V +        E    PVP +                  +EE+ +
Sbjct: 226 VADAKVEKPEKAKSPVPKS----PVEEKGKSPVPKSP-----------------VEEKGK 264

Query: 190 PGVPEESLRVQHEETGLEP-PEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRES 248
             VP+  +    EE G  P P+   ++     + +S  E   + P    P++P E  +  
Sbjct: 265 SPVPKSPV----EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPV---PKSPVEEAKSK 317

Query: 249 TEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKA--TEEKGTELPE 306
            E  + E  E+      EKE +++ +E  +E  EE   +VPE+ + ++   EE   E+  
Sbjct: 318 AEVGKGEQKEEE-----EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVT 372

Query: 307 RTKPDFPDHKPRKSTDENVPEPLEEIK----------LEFPEEESRKTNEETILEQSEMM 356
            TK     H  +++ +E  P   E+ K           E  ++ ++ + +E I    E+ 
Sbjct: 373 ITK-SVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEV- 430

Query: 357 KPESPEEIRKSNEKKNPQPPEETGPVL-PQEINPQVEEKTQTKPTEKILELPDETKPRET 415
             E  EE+ +  ++K     EE G V    +++P  E+K   K  EK++     TK  E 
Sbjct: 431 --EGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVV----VTKTVEK 484

Query: 416 HVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRK 457
                 +   + I    +V     EH E    KL  + K  K
Sbjct: 485 ITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 120/538 (22%), Positives = 210/538 (39%), Gaps = 68/538 (12%)

Query: 24  ELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTS 83
           E+    KL E  E      A S +   +Y    P T     ++ + ++ K   LK     
Sbjct: 21  EIAAYRKLLEGEETRFSTFAGS-ITGPLYTHRPPITISSKIQKPKVEAPK---LKVQHKF 76

Query: 84  QEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKP 143
            E I +E+K +           + KSE    +    ++L   M E  KE+  E  EE  P
Sbjct: 77  VEEIIEETKVE-----------DEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE--P 123

Query: 144 NVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEE 203
              E+   E A +  P      E + E  G    E   E  EEE E    +++     E+
Sbjct: 124 EAEEE---EVAAKKSPVKATAPE-VKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179

Query: 204 TGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE-ETQRESTEKKRTEPPEQARL 262
            G    E+ +Q+    +     EE + +  K  + ++ E  T+ E     + E PE+A+ 
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK- 238

Query: 263 EFLEKEPRKSSEEAGLEP----PEETQPEVPEEMQRKATEEKG------TELPERTKPDF 312
                 P+   EE G  P    P E + + P  + +   EEKG      + + E+ K   
Sbjct: 239 ---SPVPKSPVEEKGKSPVPKSPVEEKGKSP--VPKSPVEEKGKSPVPKSPVEEKGKSPV 293

Query: 313 PDHKPRKSTDENVPE-PLEEIKLEF------PEEESRKTNEETILEQSEMMKPESPEEIR 365
                 +     VP+ P+EE K +        +EE  K  +E   E+    K E P+++ 
Sbjct: 294 SKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVP 353

Query: 366 KSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRP 425
           +  + ++P   E    V+    + +V  + +TK   K L+   E +  +   E   E+  
Sbjct: 354 EKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ--QEKEKEKAGGEGGSEEEG 411

Query: 426 EPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKL 485
               +K S   D   +     G++   ++  +E    GS RE E+ + T+   L P    
Sbjct: 412 SDKGAKGSRKEDIAVN-----GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP---- 462

Query: 486 LNVSEECSYSDPSESQTELSEFVHE---------KEVVDLSQELKERVSEDDETQPEK 534
              ++E    D SE +  +++ V +          + +  S  + ++V E +ET  EK
Sbjct: 463 ---ADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 85/379 (22%), Positives = 155/379 (40%), Gaps = 35/379 (9%)

Query: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
           +RE+  ++ E+E +    EE +R Q E+   +           E+L E  ++   Q  KM
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ----------EERLWEQEKQMREQEQKM 354

Query: 236 TKPET----PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEE 291
              E      +E  RE  E+ R +     + E +++E R    E  +   EET  E  E+
Sbjct: 355 RDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414

Query: 292 MQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE 351
           MQ++       E  E  +   P+ K +    E + E          +EE     EE I +
Sbjct: 415 MQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE----------QEEKIWEQEEKIRD 464

Query: 352 QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETK 411
           Q EM   E     ++   ++  Q  E+   +  QE     +E+   +  E++ E   E +
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE--KEER 522

Query: 412 PRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEES 471
            RE    + +E++    K          +  E  R +  + ++ +K       +RE EE 
Sbjct: 523 MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK-------MREEEEM 575

Query: 472 IGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQ 531
           +    E +Q  ++ +   EE  + +  E   E  E + E+E     QE ++++ E +E  
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMW-EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMM 634

Query: 532 PEKGTELQ-FEHLNWDPEE 549
            E+  ++Q  E   W+ EE
Sbjct: 635 WEQEEKMQEQEEKMWEQEE 653



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 103/439 (23%), Positives = 178/439 (40%), Gaps = 48/439 (10%)

Query: 120 KDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRE- 178
           K  +  ++E  KE D    E  +  +T +   +   E            SE+    V+E 
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQ-LNVKEL 213

Query: 179 -RNLE---LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETD----L 230
            R LE    L  + +    +E +  Q EE   +  +  KQ+    +  E L E +     
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
           Q  KM + E     Q +   ++  E  EQ +L   E+E +   +E  +   EE   E  E
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLR--EQEEQMQEQEEKMWEQEEKMREQEE 331

Query: 291 EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETIL 350
           +M R+  EE+   L E+ K      +  +  +E + E  E ++    E+E R   +E + 
Sbjct: 332 KMWRQ--EER---LWEQEKQMREQEQKMRDQEERMWEQDERLR----EKEERMREQEKMW 382

Query: 351 EQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDET 410
           EQ E M+ E  E IR+  +K      EE   +  QE   Q +E+   +  EK  E   + 
Sbjct: 383 EQEEKMQEE--ERIREREKKMR----EEEETMREQEEKMQKQEENMWEQEEK--EWQQQR 434

Query: 411 KPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEE 470
            P +    + +E   E  + K     +++  +E   G+        K+ +    +RE E+
Sbjct: 435 LPEQKEKLWEQEKMQEQ-EEKIWEQEEKIRDQEEMWGQ-------EKKMWRQEKMREQED 486

Query: 471 SIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDET 530
            +    E ++         +E    D  E   E  E + EKE  +  +E K+   ++++ 
Sbjct: 487 QMWEQEEKMR--------DQEQKMWDQEERMWEQDERLREKE--ERMREQKKMWQQEEKM 536

Query: 531 QPEKGTELQFEHLNWDPEE 549
           + EK T+ Q E   WD EE
Sbjct: 537 REEKKTQEQ-EKKTWDQEE 554



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 83/361 (22%), Positives = 147/361 (40%), Gaps = 21/361 (5%)

Query: 36  EPDTMAKADSKLPAEIYQEPQPETEEEDFKEGE-PDSAKNVQLKPGGTSQEGIAKESKRD 94
           E +TM + + K+  +  +E   E EE+++++   P+  + +  +     QE    E +  
Sbjct: 404 EEETMREQEEKMQKQ--EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461

Query: 95  VPSETEPGIHQEV--KSETSREMGEFFKDLEAPM-DETHKESDLEPPE-EAKPNVTEDVF 150
           +  + E    ++   + E  RE  +   + E  M D+  K  D E    E    + E   
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREK-- 519

Query: 151 LESAMETDPDPVPPTETMSEVSGATVRERNLELLEEET--EPGVPEESLRVQHEETGLEP 208
            E  M          E M E      +E+     EE+   E  + E   +++ EE  +  
Sbjct: 520 -EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 578

Query: 209 PEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL-EK 267
            E+  Q+   EK+ E  E+   Q  KM + E     Q E   ++  E   Q + E + E+
Sbjct: 579 QEEKMQE-QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQ 637

Query: 268 EPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPE 327
           E +   +E  +   EE   E  E+M+ +  + +G E   R + +    +  K  ++    
Sbjct: 638 EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697

Query: 328 PLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEE----TGPVL 383
             +E K+ + +EE     EE +  Q EM + E  E IR   EK   + PE     + P L
Sbjct: 698 RGQEEKM-WGQEEKMWGQEEKMWGQEEMREKE--ERIRDQKEKMQERLPEHEERCSEPCL 754

Query: 384 P 384
           P
Sbjct: 755 P 755



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 58/270 (21%), Positives = 117/270 (43%), Gaps = 18/270 (6%)

Query: 298 EEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMK 357
           ++K  EL E+ +    +    +   + +   LE  K   P+ ++    EE   ++ E+ +
Sbjct: 186 KKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELRE 245

Query: 358 PESPEEIRKSNEKKNPQPP---EETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRE 414
            E  ++IRK  EK   Q     E+ G +  QE   + +EK   +  +++ E   E + RE
Sbjct: 246 QE--KKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELRE--QEKELRE 301

Query: 415 THVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGT 474
                 +E++ +  + K     +++  +E K  +        + +     +RE E+ +  
Sbjct: 302 QKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE-----ERLWEQEKQMREQEQKMRD 356

Query: 475 HYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEK 534
             E +    + L   EE       E   E  E + E+E +   +E ++++ E++ET  E+
Sbjct: 357 QEERMWEQDERLREKEERMREQ--EKMWEQEEKMQEEERI---REREKKMREEEETMREQ 411

Query: 535 GTELQFEHLNWDPEEVAEWISQLGFPQYKE 564
             ++Q +  N   +E  EW  Q   P+ KE
Sbjct: 412 EEKMQKQEENMWEQEEKEW-QQQRLPEQKE 440



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 80/368 (21%), Positives = 145/368 (39%), Gaps = 32/368 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           +E +   EEE  +E E    + +Q +     ++   +  ++ +P + E    QE   E  
Sbjct: 397 REKKMREEEETMREQE----EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452

Query: 113 R---EMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMS 169
               E  E  +D E    +  K    E   E +  + E    E  M      +   E   
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ---EEKMRDQEQKMWDQEERM 509

Query: 170 EVSGATVRERNLELLEEETEPGVPEESLRV------QHEETGLEPPEQTKQDFPSEKLGE 223
                 +RE+  E + E+ +    EE +R       Q ++T  +  +  +++   E+  +
Sbjct: 510 WEQDERLREKE-ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKK 568

Query: 224 SLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEE 283
             EE ++   +  K +  EE  RE  EK   +  +    E    E     EE   E  EE
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE----EKMWEQEEKMWEQEEE 624

Query: 284 TQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRK 343
            + +  EEM  +  EEK  E  E+    +   +  +  +E + E  E+++    +EE  +
Sbjct: 625 DKMQEQEEMMWEQ-EEKMQEQEEKM---WEQEEKMREQEEKMREQEEKMQ---GQEEKMR 677

Query: 344 TNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETG---PVLPQEINPQVEEKTQTKPT 400
             EE +  Q E M+ E  E++R   EK   Q  +  G    +  QE   + EE+ + +  
Sbjct: 678 EQEEKMQGQEEKMR-EQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE 736

Query: 401 EKILELPD 408
           +    LP+
Sbjct: 737 KMQERLPE 744


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 107/480 (22%), Positives = 182/480 (37%), Gaps = 51/480 (10%)

Query: 39  TMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSE 98
           T+  A   LP+   Q    E E  + +E      +  +++   T  +   K   RD    
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183

Query: 99  TEPGIHQEVKSETSREMGEFFKD-LEAPMDETHKESDLEPPEEAKPN---VTEDVFLESA 154
            +    +E + E   + G   ++ +E  ++E   ES  E    +  N    +E+   E  
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243

Query: 155 METDPDPVPPTETM-------SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLE 207
            E   D +   E M       +E   A +     E ++ E +  + +E  R++ EE    
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303

Query: 208 PPEQTKQDFPSEKLGESLEET--DLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL 265
              + ++    E++ E  +    + Q  K  +    EE QR   E+KR     + R    
Sbjct: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA---EERQRIK 360

Query: 266 EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPE-RTKPDFPDHK--PRKSTD 322
           E+E R + E       EE + +V E+ + K  EEK   + E + K +  + K   +   +
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420

Query: 323 ENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPE-SPEEIRKSNEKKNPQPPEETGP 381
           +   E   +  +   + E + T  +   E+ +  KP    EEI+    KK+ +P EE   
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480

Query: 382 VLPQ-----EINPQVEE--KTQTKPTEKILELPD-----ETKPRE--THVEFSK------ 421
            + +     E+  Q  E    + K TE     P      +TK  E    VE  K      
Sbjct: 481 FMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540

Query: 422 -------EDRPEPIKSKYSVGNDELEH----REPKRGKLSLSDKFRKEYYALGSLRESEE 470
                   +  E +K K      ELE     RE +R  L   ++ RK+  A   LRE EE
Sbjct: 541 RRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 75/342 (21%), Positives = 133/342 (38%), Gaps = 38/342 (11%)

Query: 139 EEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSG----------ATVRERNLELLEE-- 186
           EE+   VT+ V + +      +    T T ++V G          A   ER  + L+E  
Sbjct: 56  EESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEAL 115

Query: 187 ----ETEPGVPEESLRV--QHEETGLEPPEQTKQDFPSEKLGE--SLEETDLQPPKMTKP 238
               E +P + + SL +  +  +      E T+++  SE   E   +EET+       K 
Sbjct: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175

Query: 239 E--TPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKA 296
           +    EE ++E  EK+  E  +  R    E +     EE   E  EET     +  Q  +
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235

Query: 297 TEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPE------EESRKTNEETIL 350
            E K  E  E+   +   H+  +  D+   E  E  +LE  E      E+ +K  +E   
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAE-AERARLEAEERERIKAEQDKKIADERAR 294

Query: 351 EQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQ----VEEKTQTKPTEKIL-- 404
            ++E        E R++ E++  +  E+      Q I  +     EE+ + K  EK    
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354

Query: 405 ---ELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHRE 443
               + +E K      + ++ +  E  K +    N +LE ++
Sbjct: 355 ERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK 396



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 91/406 (22%), Positives = 156/406 (38%), Gaps = 48/406 (11%)

Query: 19  EPERPELPGLHKLYEN----AEPDTMAKADSKLPAEIYQ-----EPQPETEEEDFKEGEP 69
           E ER E     ++ E     AE     K + K  AE  Q     E +   E +  KE E 
Sbjct: 305 ERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 364

Query: 70  DSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREM----GEFFKDLEAP 125
            +A+  Q       ++   +E KR+   E +    QE K +  +      G++  + +A 
Sbjct: 365 RAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQ 424

Query: 126 MDE--------------THKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTET-MSE 170
            D+              T  ++  E  +E KP   ++   +  ++ D +P    ++ M  
Sbjct: 425 EDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDR 484

Query: 171 VSGAT-VRERNLELLEEE---TEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLE 226
             G T V+ +N E +  +   TE        R   +    E   Q +     E+L     
Sbjct: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG 544

Query: 227 ETDLQPPKMTKPETPEET-QRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQ 285
           ET+ +  +  K +  E   + E  +KKR    E+ R    E+E R+  EEA  +  EE +
Sbjct: 545 ETESEEFEKLKQKQQEAALELEELKKKR----EERRKVLEEEEQRRKQEEADRKLREEEE 600

Query: 286 PE-VPEEMQRKATE--EKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESR 342
              + EE++R+  E  EK  ++PE    D  D KP K           E + EF  +  +
Sbjct: 601 KRRLKEEIERRRAEAAEKRQKMPEDGLSD--DKKPFKCFTPKGSSLKIEERAEFLNKSVQ 658

Query: 343 K------TNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPV 382
           K      T++  I+ + +    +    I  +   K  +P     PV
Sbjct: 659 KSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPV 704


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 55/250 (22%), Positives = 114/250 (45%), Gaps = 10/250 (4%)

Query: 176 VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKM 235
           VRE+  ++ E+E + G  E  +  Q E+ G +  +  KQ+   E++GE  E+   Q  +M
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE---EQMGEQEEQMRKQEEQM 236

Query: 236 TKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVP---EEM 292
            + E   + Q E  +K+  +  +Q      ++E  +  EE  L+  E+T+ E     +E 
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296

Query: 293 QRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQ 352
           Q +  EE+  E  E+ +      + ++       E + E K +  E++ +   +E  + +
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGE 356

Query: 353 SEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKP 412
            E    +  E++RK  E+   Q  +    +  QE   + +E+   +  E++ E  ++ + 
Sbjct: 357 QEEQMQKQEEQVRKQEEQMRKQEEQ----MRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412

Query: 413 RETHVEFSKE 422
           +E  +   KE
Sbjct: 413 QEEQMGEQKE 422



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 60/296 (20%), Positives = 125/296 (42%), Gaps = 22/296 (7%)

Query: 176 VRERNLELLEEETEPGVPEESLRVQ----HEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
           VRE+  ++ E+E +    E  +R Q     E+ G    ++ +     E++GE  E+   Q
Sbjct: 159 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEE 291
             +M + E     Q E   ++  +  +Q      ++E  +  EE   E  E+ + +  + 
Sbjct: 219 EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM 278

Query: 292 MQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE 351
           +++K   E+  +  E+ +      +  +  +E + E  E+++    +EE     EE + E
Sbjct: 279 LKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR---EQEEQMGKQEEQMWE 335

Query: 352 QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETK 411
           Q E M  E  E++ K  E+              QE   Q +E+   K  E++ +  ++ +
Sbjct: 336 QKEQMW-EQKEQMWKQEEQMG-----------EQEEQMQKQEEQVRKQEEQMRKQEEQMR 383

Query: 412 PRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRE 467
            +E  +   +E   E    K  +G  + + RE +       ++ RK+   +G  +E
Sbjct: 384 KQEEQMRKQEEQMGE---QKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 48/261 (18%), Positives = 112/261 (42%), Gaps = 15/261 (5%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETS 112
           +E + +  E++ + GE +     Q +  G  +E + K+ ++    E +    +E   E  
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240

Query: 113 REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDP-VPPTETMSEV 171
            ++ +  + ++   ++  K+ +    +E +    E+  L+   +T+ +      E     
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300

Query: 172 SGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQ 231
               +RE+  ++ E+       EE +R Q E+ G +  +  +Q    E++ E  E+   Q
Sbjct: 301 QEEQMREQEEQMREQ-------EEQMREQEEQMGKQEEQMWEQ---KEQMWEQKEQMWKQ 350

Query: 232 PPKMTKPETPEETQRESTEKKRTEPPEQ-ARLEFLEKEPRKSSEEAGLEPPEETQPEVPE 290
             +M + E   + Q E   K+  +  +Q  ++   E++ RK  E+ G    ++ Q    +
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG---EQKEQMGEQK 407

Query: 291 EMQRKATEEKGTELPERTKPD 311
           E  R+  E+ G +  +  K +
Sbjct: 408 EQMREQEEQMGEQKEQMRKQE 428



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 63/345 (18%), Positives = 136/345 (39%), Gaps = 26/345 (7%)

Query: 233 PKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPE-- 290
           P++T  E  E+      E +  E  E++ ++   KE ++  E   +  P+E Q    E  
Sbjct: 2   PRITNEELKEKNAELQEELQLVET-EKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQ 60

Query: 291 --EMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEET 348
             E + +  E++G    +  +    + + R+   +     + E + +  E+E +   +E 
Sbjct: 61  VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ-----VREQEGQVREQEGQVREQEG 115

Query: 349 ILEQSEMMKPESPEEIRKSN---EKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILE 405
            + + E    E   ++R+      ++  Q  E+ G V  QE   + +E    +   ++ E
Sbjct: 116 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 175

Query: 406 LPDETKPRETHVEFSK----EDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYA 461
              + + +E  V   +    E   +  + +  +G  E + ++ +       ++ RK+   
Sbjct: 176 QEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQ 235

Query: 462 LGSLRES----EESIGTHYEFLQPLQKLLNVSEECSYSDPSE-----SQTELSEFVHEKE 512
           +G   E     EE +    E ++  ++ +   EE       +      QTE  E   E+E
Sbjct: 236 MGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQE 295

Query: 513 VVDLSQELKERVSEDDETQPEKGTELQFEHLNWDPEEVAEWISQL 557
                QE + R  E+   + E+    Q E +    E++ E   Q+
Sbjct: 296 EQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340


>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
           sapiens]
          Length = 1158

 Score = 66.6 bits (161), Expect = 7e-11
 Identities = 91/370 (24%), Positives = 154/370 (41%), Gaps = 60/370 (16%)

Query: 111 TSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSE 170
           T  E+ EF +   + ++   +E D+E P   +P            +    P     T +E
Sbjct: 30  TDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPR-----VRKAQAGGKPGKRPGTAAE 84

Query: 171 VSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDL 230
           V     +++  +  +++  P VP+ESL     E    PP++ K     EK  ++ ++   
Sbjct: 85  VPPEKTKDKG-KKGKKDKGPKVPKESL-----EGSPRPPKKGK-----EKPPKATKKPKE 133

Query: 231 QPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEV-P 289
           +PPK TK   P+E   ++T+K + +PP+  +     K P   +    LE P    P   P
Sbjct: 134 KPPKATK--KPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGP 191

Query: 290 EEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIK---LEFPEEESRKTNE 346
           EE+     +E G  L    +   P  +      E+ PEP EE +   L++ ++  R+  E
Sbjct: 192 EEL----PQEGGAPLSNNWQN--PGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYE 245

Query: 347 --ETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPV-LPQE-INPQVEEKTQTKP--- 399
             E I  Q +   P  P   R+  E+  P+PPEE  P   P+E I P V+      P   
Sbjct: 246 DFEYIRRQKQ---PRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDY 302

Query: 400 -----------TEKILELPDETKP-RETHVEFSKEDRPEPIK---------SKYSVGNDE 438
                       +     P   KP  E   +  KE+  +P K          K++V   +
Sbjct: 303 GDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGK 362

Query: 439 LEHREPKRGK 448
            +H+EP++G+
Sbjct: 363 -DHKEPRKGE 371



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 80/360 (22%), Positives = 117/360 (32%), Gaps = 90/360 (25%)

Query: 12  PDEDGELEPERPE-LPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPD 70
           P ED    P  PE  P + K     +P       +++P        PE  ++  K+G+ D
Sbjct: 49  PREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVP--------PEKTKDKGKKGKKD 100

Query: 71  SAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETH 130
               V  +    S EG  +  K+    E  P   ++ K +  +      K  E P   T 
Sbjct: 101 KGPKVPKE----SLEGSPRPPKKG--KEKPPKATKKPKEKPPKATK---KPKEKPPKATK 151

Query: 131 KESDLEPPEEAKPNVTEDVFLESAMET-----DPDPVPPTETMSEVSGATVRERNLELLE 185
           K  +  P    KP   +   + +  ET      P P P  E + +  GA        L  
Sbjct: 152 KPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAP-------LSN 204

Query: 186 EETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQP------------- 232
               PG   E   V+  E   EP E+T+Q  P+    + +E  D +              
Sbjct: 205 NWQNPG---EETHVEAREHQPEPEEETEQ--PTLDYNDQIEREDYEDFEYIRRQKQPRPP 259

Query: 233 ------PKMTKPETPEETQRESTEKKRTEPPEQARLEFL--------------------- 265
                 P+   PE PEE       ++R EPP +  L  L                     
Sbjct: 260 PSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFG 319

Query: 266 ---------------EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKP 310
                          EKE  K  ++    P EET     E+ +      KG EL E   P
Sbjct: 320 PPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTP 379



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 29/91 (31%), Positives = 41/91 (45%), Gaps = 9/91 (9%)

Query: 188  TEPGVPEESLRVQHEETGLEPPEQTK-QDFPSEKLGESLEE--TDLQPPKMTKPETPEET 244
            T P  P  +L    E  GL PP     ++  +E   E + E  T+++P   TK E   ET
Sbjct: 1052 TLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFET 1111

Query: 245  QRESTEKKRTEPPEQARLEFLEKEPRKSSEE 275
            Q E   + + EP      EF E+E  +  EE
Sbjct: 1112 QLEPEFETQLEP------EFEEEEEEEKEEE 1136


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 95/447 (21%), Positives = 178/447 (39%), Gaps = 39/447 (8%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQL----KPGGTSQEGIAKESKRDVPSETEPGIHQEVK 108
           QE +   +EE  +E E    +  ++    +     QE +  E +  +  + E    +E K
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 378

Query: 109 SETSREM----GEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPP 164
                EM     E  ++LE  M E  K  + E   + +  + E    E   E +      
Sbjct: 379 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ---EKRQEQEAKMWRQ 435

Query: 165 TETMSEVSGATVRERNLELLEEETEPGVPEESL----RVQHEETGLEPPEQTKQD---FP 217
            E         +RE+  ++ E+E +    EE +    +++ EE   E  E  +Q+     
Sbjct: 436 EEK--------IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHE 487

Query: 218 SEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAG 277
            E++    E+   Q  K+ K E     Q E   ++  +  EQ    + ++E  +  EE  
Sbjct: 488 QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547

Query: 278 LEPPE-ETQPEVPEEMQRKATEEKGTELPERTK-PDFPDHKPRKSTDENVPEPLEEIKLE 335
            E  +   Q ++ EE +R+  E+K     E+ +  +    +  +   E   +  E+ +  
Sbjct: 548 REEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKM 607

Query: 336 FPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPP---EETGPVLPQEINPQVE 392
           + +EE  +  EE I EQ E ++ E  E+IR+  E    Q     E+   +  QE   Q +
Sbjct: 608 WKQEEKIREQEEKIQEQEEKIR-EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666

Query: 393 EKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLS 452
           E+T  +  EKI E   + + +E  +   +E   E  +  +       E  E  + +    
Sbjct: 667 EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQ---E 723

Query: 453 DKFRKEYYALGS----LRESEESIGTH 475
           +K R++   +      LR+ EE +  H
Sbjct: 724 EKMRRQEEKMWEQEVRLRQQEEKMQEH 750


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 110/449 (24%), Positives = 153/449 (34%), Gaps = 74/449 (16%)

Query: 12  PDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPET-------EEEDF 64
           P E+  L P   E P          P   A   S  P E+   P PE        EE   
Sbjct: 443 PPEESPLSPPPEESP--------TSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPL 494

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
               P   ++    P  +S     +ES    P E+ P    E       E         +
Sbjct: 495 S---PPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEA--------S 543

Query: 125 PMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELL 184
           P+    +ES L PP E  P          +   +  P+ P    S +S      R     
Sbjct: 544 PLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPF 603

Query: 185 EEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET 244
           EE      PEES         L PP +      + +L    E++ + PP    P +P   
Sbjct: 604 EESPLSPPPEES--------PLSPPPE------ASRLSPPPEDSPMSPPPEESPMSP--- 646

Query: 245 QRESTEKKRTEPPEQARLEFLEKEPRKS--SEEAGLEPPEETQP-EVPEEMQRKA--TEE 299
                      PPE +RL  L    R S   EE+ L PP E  P   P E  R +   E+
Sbjct: 647 -----------PPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPED 695

Query: 300 KGTELPERTKPDFPDHKPRKSTDENVPEPLEEIK-LEFPEEES---RKTNEETILEQSEM 355
             T  P    P  P  +     D  +  PLEE   L  PEE     R           E 
Sbjct: 696 SPTSPPPEDSPASPPPE-----DSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEP 750

Query: 356 MKPESPEEIRKSNEKK----NPQPPEETGPVLPQE--INPQVEEKTQTKPTEKILELPDE 409
                PEE   S + +    +PQP E     +P+E  ++PQ E    +   E++   P  
Sbjct: 751 HLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQT 810

Query: 410 TKPRETHVEFSKEDRPEPIKSKYSVGNDE 438
            +P  + V       P+P +S  S  ++E
Sbjct: 811 EEPHLSPVPEEPCLSPQPEESHLSPQSEE 839



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 98/439 (22%), Positives = 143/439 (32%), Gaps = 70/439 (15%)

Query: 1    MAEVPEDYDSGPDEDG-ELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPET 59
            +  VPE+    P  +G  L P+  EL        +  P T     S +P E    PQPE 
Sbjct: 779  LCAVPEEPHLSPQAEGPHLSPQPEEL--------HLSPQTEEPHLSPVPEEPCLSPQPEE 830

Query: 60   EEEDFKEGEP-------DSAKNVQL----------KPGGTSQEGIAKESKRDVPSETEPG 102
                 +  EP       +S  + +L          KP     +  A E     P   EP 
Sbjct: 831  SHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPS 890

Query: 103  IHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPV 162
            +   +      E GE       P+    +E  L P  E  P+++  +         PDP+
Sbjct: 891  LSPLLGEPALSEPGE------PPLSPLPEELPLSPSGE--PSLSPQLM-------PPDPL 935

Query: 163  PPTETMSEVSGATVRERNLELLEEETEPGV-----PEESLRVQHEETGLEPPEQTKQDFP 217
            PP   +S +  A        L E E   G      PE  L     ET + PP +     P
Sbjct: 936  PPP--LSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDP 993

Query: 218  SEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEA- 276
                   L      PP    P  P           +  P  Q  L      P + S  A 
Sbjct: 994  EPVPPMIL------PPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPAL 1047

Query: 277  GLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEF 336
             L  P    P           E    E  + ++P+ P  +P  S    +P P+ ++    
Sbjct: 1048 PLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEP--SATSPLPSPMGDLSCPA 1105

Query: 337  PE-----EESRKTNEET-----ILEQSEMMKPESPEEIRKSNEKKNPQ--PPEETGPVLP 384
            P      ++     E+T     I       +P        S  K +P    PEE  PV P
Sbjct: 1106 PSPAPALDDFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTP 1165

Query: 385  QEINPQVEEKT-QTKPTEK 402
             E+ P+ ++   Q  P E+
Sbjct: 1166 MEVYPECKQTAGQGSPCEE 1184


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 90/424 (21%), Positives = 172/424 (40%), Gaps = 40/424 (9%)

Query: 53  QEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKS--- 109
           Q+ +   +EE  +E E    +  +++     QE   K   ++   + E  I +  K    
Sbjct: 402 QDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE 461

Query: 110 --ETSREMGEFFKDLEAPM-DETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTE 166
             ET RE  E  +  E  M ++  KE   +   E K  + E   ++   E   +      
Sbjct: 462 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521

Query: 167 TMSEVSGAT--------VRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPS 218
              E+ G          +RE+  ++ E+E +    E+ +  Q E    +  EQ K+ +  
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581

Query: 219 EKLGESLEETDLQPPKMTKPETPEETQRESTEK--KRTEPPEQARLEFLEKEPRKSSEEA 276
           E   E + E +    +  K    EE  RE  EK  ++ E  ++   +  E+E +   +E 
Sbjct: 582 E---EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638

Query: 277 GLEPPEE----------TQPEVPEEMQRKATEEKGTE---LPERTKPDFPDHKPRKSTDE 323
            +   EE           Q  +PE+ ++    EK  E   + E+ +  +   K  K T E
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698

Query: 324 NVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPE--ETGP 381
              +  ++ K+   EEES +  E+ + E+ EMM+ E  E++++  EK   Q  E  E   
Sbjct: 699 QEKKTWDQEKMR--EEESMREREKKMREEEEMMR-EQEEKMQEQEEKMQEQEEEMWEQEE 755

Query: 382 VLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEH 441
            + ++     E++   +  EK+ E     K +E    + +E++    + K     +++  
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWE---HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812

Query: 442 REPK 445
           +E K
Sbjct: 813 QEEK 816



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 87/446 (19%), Positives = 183/446 (41%), Gaps = 23/446 (5%)

Query: 120 KDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRE- 178
           K  +  ++E  KE D    E  +  +T +   +   E   + +P  E+        V+E 
Sbjct: 193 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQ-EKLPLAESEKSEIQLNVKEL 251

Query: 179 -RNLE---LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPK 234
            R LE    L  + +    +E +  Q EE   +  +  KQ+   EK+    E    Q  K
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQE---EKMWRQEERLREQEGK 308

Query: 235 MTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQR 294
           M + E     Q +   ++  E  EQ +    +KE R+  E+  ++  EE   E  E+M+ 
Sbjct: 309 MREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQ--MQEQEEKMWEQEEKMRE 366

Query: 295 KATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
           +  EEK     ER        + ++    +  E + E      E+E R   +E + EQ E
Sbjct: 367 Q--EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424

Query: 355 MMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRE 414
            M+ E   + ++   +   +  +E   +  +E   + EE+T  +  EK ++  +E    +
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK-MQKQEENMWEQ 483

Query: 415 THVEFSKEDRPEPIKSKYSVGNDELEHREPK----RGKLSLSDKF---RKEYYALGSLRE 467
              E+ ++  PE  +  +    ++++ +E K      K+   ++     K+ +    +RE
Sbjct: 484 EEKEWQQQRLPEQKEKLWE--QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 541

Query: 468 SEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSED 527
            E+ +    E ++  ++ +   EE       E + +  +   +    +  +E ++++ E+
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601

Query: 528 DETQPEKGTELQFEHLNWDPEEVAEW 553
           +E   E+  ++Q +      +E   W
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMW 627



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 74/330 (22%), Positives = 143/330 (43%), Gaps = 55/330 (16%)

Query: 240 TPEETQRESTEKKRTEP---PEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKA 296
           T EE ++++ E +   P    E++ ++   KE ++  E A    P+     + EEM R+ 
Sbjct: 219 TNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ- 277

Query: 297 TEEKGTELPERTKPDFPDHKPRKSTDE--NVPEPLEEIKLEFPEEESRKTNEETILEQSE 354
            EE   EL E+ K      K RK  ++     E L E + +  E+E +   +E  L + E
Sbjct: 278 -EE---ELREQEK------KIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQE 327

Query: 355 MMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRE 414
               E  +E+R+  E +             QE   Q +E+   +  EK+ E  ++     
Sbjct: 328 KELREQEKELREQKELRE------------QEEQMQEQEEKMWEQEEKMREQEEKM---- 371

Query: 415 THVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGT 474
               + +E+R         +   E + RE ++    + D+  + +     LRE EE +  
Sbjct: 372 ----WRQEER---------LWEQEKQMREQEQ---KMRDQEERMWEQDERLREKEERMRE 415

Query: 475 HYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEK 534
             +  + ++K+    EE    +  +   +  E + E+E +   +E ++++ E++ET  E+
Sbjct: 416 QEKMWEQVEKM---REEKKMQEQEKKTRDQEEKMQEEERI---REREKKMREEEETMREQ 469

Query: 535 GTELQFEHLNWDPEEVAEWISQLGFPQYKE 564
             ++Q +  N   +E  EW  Q   P+ KE
Sbjct: 470 EEKMQKQEENMWEQEEKEW-QQQRLPEQKE 498



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 69/345 (20%), Positives = 137/345 (39%), Gaps = 23/345 (6%)

Query: 28  LHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGI 87
           + K  +  E  T  + +     E  +E + +  EE+    E +     Q +     +E +
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM 626

Query: 88  AKESKRDVPSETEPGIHQEVKSETSREMGEFFK--DLEAPMDETHKESDLEPPEEAKPNV 145
            ++ ++    E +    +E   E   +M E  +  + +  + E  K  + E  +E +  +
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686

Query: 146 TEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETG 205
            E   +E   +         E M E    ++RER  ++ EEE      EE ++ Q E+  
Sbjct: 687 WEQEKMEKKTQEQEKKTWDQEKMREEE--SMREREKKMREEEEMMREQEEKMQEQEEKMQ 744

Query: 206 LEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFL 265
            +  E  +Q+   EK+ E  E+   Q     + E   E ++   ++K  E  E+ R    
Sbjct: 745 EQEEEMWEQE---EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR---- 797

Query: 266 EKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENV 325
           ++E +   +E  +   EE      E+M  +  +  G E     +  +   +     +E +
Sbjct: 798 DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQE-----EKMWGQEEKMWGQEEKM 852

Query: 326 PEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEK 370
            E ++       +EE  +  EE +  Q E M+ E  E++R   EK
Sbjct: 853 EEKMQ------GQEEKMREQEEKMRGQEEKMR-EQEEKMRGQEEK 890


>gi|118722349 RNA binding motif protein 12B [Homo sapiens]
          Length = 1001

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 77/311 (24%), Positives = 115/311 (36%), Gaps = 24/311 (7%)

Query: 131 KESDLEPPEEAKPNVTEDVFLESAMETDPDPV--PPTETMSEVSGATVRERNLELLEEET 188
           ++ D  PPE+ + +  +  F        P+    P  E     S     E +     EE 
Sbjct: 548 RQPDRHPPEDFRHSSEDFRFPPEDFRHSPEDFRRPREEDFRRPS-----EEDFRRPWEED 602

Query: 189 EPGVPEESLRVQHEETGLEPPEQT-----KQDF---PSEKLGESLEETDLQPPKMTKPET 240
               PE+  R   EE    P E+      ++DF   P+E   +  EE   QPP+      
Sbjct: 603 FRRPPEDDFRHPREEDWRRPLEEDWRRPLEEDFRRSPTEDFRQLPEEDFRQPPEEDLRWL 662

Query: 241 PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK 300
           PEE  R   E+    PPE+     L+ E R+  E+    PPEE     PEE  R++ +E 
Sbjct: 663 PEEDFRRPPEEDWRRPPEEDFRRPLQGEWRRPPEDDFRRPPEEDFRHSPEEDFRQSPQEH 722

Query: 301 GTELPE----RTKPDF-----PDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE 351
               P+    R  P+      P+H  R   +     P E  +   PE   R   E     
Sbjct: 723 FRRPPQEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRPPPEHFRRP 782

Query: 352 QSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETK 411
             E  +    E  R+S E+    PP+E     P E      ++    P E+    P +  
Sbjct: 783 PQEHFRRPPQEHFRRSREEDFRHPPDEDFRGPPDEDFRHPPDEDFRSPQEEDFRCPSDED 842

Query: 412 PRETHVEFSKE 422
            R+   E  +E
Sbjct: 843 FRQLPEEDLRE 853



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 62/230 (26%), Positives = 89/230 (38%), Gaps = 9/230 (3%)

Query: 184 LEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEE 243
           L EE     PEE LR   EE    PPE+  +  P E     L+    +PP+      PEE
Sbjct: 646 LPEEDFRQPPEEDLRWLPEEDFRRPPEEDWRRPPEEDFRRPLQGEWRRPPEDDFRRPPEE 705

Query: 244 TQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTE 303
             R S E+   + P+       E   R   E     PPE  +   PE  +R   E     
Sbjct: 706 DFRHSPEEDFRQSPQ-------EHFRRPPQEHFRRPPPEHFRRPPPEHFRRPPPEHFRRP 758

Query: 304 LPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILE-QSEMMKPESPE 362
            PE  +   P+H  R+   E+   P +E     P+E  R++ EE       E  +    E
Sbjct: 759 PPEHFRRPPPEHF-RRPPPEHFRRPPQEHFRRPPQEHFRRSREEDFRHPPDEDFRGPPDE 817

Query: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKP 412
           + R   ++    P EE       E   Q+ E+   +  E+   LPD  +P
Sbjct: 818 DFRHPPDEDFRSPQEEDFRCPSDEDFRQLPEEDLREAPEEDPRLPDNFRP 867



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 50/187 (26%), Positives = 72/187 (38%), Gaps = 2/187 (1%)

Query: 241 PEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEK 300
           P E  R S E  R  P E+      E++ R+  EE    PPE+      EE  R+  EE 
Sbjct: 568 PPEDFRHSPEDFR-RPREEDFRRPSEEDFRRPWEEDFRRPPEDDFRHPREEDWRRPLEED 626

Query: 301 GTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEM-MKPE 359
                E      P    R+  +E+  +P EE     PEE+ R+  EE      E   +  
Sbjct: 627 WRRPLEEDFRRSPTEDFRQLPEEDFRQPPEEDLRWLPEEDFRRPPEEDWRRPPEEDFRRP 686

Query: 360 SPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEF 419
              E R+  E    +PPEE     P+E   Q  ++   +P ++    P     R    E 
Sbjct: 687 LQGEWRRPPEDDFRRPPEEDFRHSPEEDFRQSPQEHFRRPPQEHFRRPPPEHFRRPPPEH 746

Query: 420 SKEDRPE 426
            +   PE
Sbjct: 747 FRRPPPE 753


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 106/510 (20%), Positives = 205/510 (40%), Gaps = 50/510 (9%)

Query: 38  DTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGI-AKESKRDVP 96
           + + K    L  E+Y+       +E+ KE      + +QL     S+  +  KE KR + 
Sbjct: 257 EELTKERDALSLELYRNT---ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLE 313

Query: 97  SETEPGIHQEVKSETS---REMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLES 153
                   Q++++E     +E+      L+A ++E    + L   +E K           
Sbjct: 314 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEK----------- 362

Query: 154 AMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTK 213
            M    + +   E   +     +RE+  ++ E+E +    EE +  + E+   +     +
Sbjct: 363 -MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 421

Query: 214 QDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSS 273
           ++    +  E + E + +  ++ +    +E  RE  EK++ E   + + +  E+E +   
Sbjct: 422 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR 481

Query: 274 EEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIK 333
           +E  +   EE   E  E+M R+  EEK              H+  K  +E   +  EE+ 
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQ--EEK-------------IHEQEKIREEEKRQEQEEMW 526

Query: 334 LEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEE 393
                +E +   +E I  Q E +  E  E+IRK  EK   Q  +    +  QE   + +E
Sbjct: 527 ----RQEEKIREQEEIWRQKEKIH-EQEEKIRKQEEKMWRQEEK----MHDQEEKIREQE 577

Query: 394 KTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSD 453
           +   +  EKI E  ++ + +E  +   +E   E    +  +G  E +  E +       +
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQE---QEEKMGEQEEKMCEQEEKMQEQEE 634

Query: 454 KFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSDPSESQTELSEFVHEKEV 513
           K R++      +RE E+ I    E ++  ++++   EE  + +  E   E  E + E+E 
Sbjct: 635 KMRRQE---EKIREQEKKIREQEEKIREQEEMMQEQEEKMW-EQEEKMCEQEEKMQEQEE 690

Query: 514 VDLSQELKERVSEDDETQPEKGTELQFEHL 543
               QE K    E    Q E+  +   EHL
Sbjct: 691 KMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720


>gi|100816397 MYST histone acetyltransferase (monocytic leukemia) 4
            [Homo sapiens]
          Length = 2073

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 99/424 (23%), Positives = 169/424 (39%), Gaps = 54/424 (12%)

Query: 21   ERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPG 80
            ER +L  L K  E++E +   + + +   E  +E + E EEE+ +E E +  +N+Q  P 
Sbjct: 1057 ERGQLLELSK--ESSEEEEEEEDEEE---EEEEEEEEEDEEEEEEEEEEEEEENIQSSPP 1111

Query: 81   G-TSQEGIAKESKRDVPSETEPG---------IHQEVKSETSREMGEFF--KDLEAPMDE 128
              T  + +A + KR    + + G         +  E  SET+  + E F   D E PM +
Sbjct: 1112 RLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQ 1171

Query: 129  THKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEET 188
                 ++E  E+ +  V     L  A +  P     TE   E  G   ++ +     +  
Sbjct: 1172 LEPTCEIEVEEDGRKPV-----LRKAFQHQPGKKRQTE---EEEG---KDNHCFKNADPC 1220

Query: 189  EPGVPEESLRVQHEETGLEPPEQTKQDFP-SEKLGESL------EETDLQPPKMTKPETP 241
               + ++S  ++        P + KQ +P   K G S        +T  +    T PETP
Sbjct: 1221 RNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETP 1280

Query: 242  EETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKG 301
                         EP EQ  +E    E +++SE      P   + EV E  +    +E+ 
Sbjct: 1281 ------------MEPDEQVTVE----EQKETSEGKTSPSPIRIEEEVKETGEALLPQEEN 1324

Query: 302  TELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESP 361
                E   P  P+  P +  ++++ +P EE + E  EEE  +  EE   E+      E  
Sbjct: 1325 RR-EETCAPVSPNTSPGEKPEDDLIKPEEEEEEE--EEEEEEEEEEEGEEEEGGGNVEKD 1381

Query: 362  EEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSK 421
             +  KS EK+ P+   E       + + + EE+ +     +  +  DE        E  K
Sbjct: 1382 PDGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHMESAEVEK 1441

Query: 422  EDRP 425
            E+ P
Sbjct: 1442 EELP 1445



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 103/471 (21%), Positives = 176/471 (37%), Gaps = 87/471 (18%)

Query: 136  EPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNL-------------- 181
            E   EA+      +   S  E +   +  T   S  S A V+ +N               
Sbjct: 999  EEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKVQSKNKYLHSPESRPVTGER 1058

Query: 182  -ELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPET 240
             +LLE   E    EE    + EE   E  E+ +++   E+  E  E     PP++TKP++
Sbjct: 1059 GQLLELSKESSEEEEEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEENIQSSPPRLTKPQS 1118

Query: 241  -------PEETQRESTEKKR------TEPPEQARLEFLEKEPRKSSEEAGLEPPEET-QP 286
                   P   +++   K+R      T        E L +    S EE  +   E T + 
Sbjct: 1119 VAIKRKRPFVLKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERPMPQLEPTCEI 1178

Query: 287  EVPEE---------------MQRKATEEKGTEL-------PERTKPDFPDHKPRKSTDEN 324
            EV E+                +R+  EE+G +        P R   +      ++ + +N
Sbjct: 1179 EVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKNADPCRNNMNDDSSNLKEGSKDN 1238

Query: 325  VPEPLEEIKL----------EFPEEESRKTN--------EETILEQSEMMKPESPEEIRK 366
             PEPL+  ++          ++ + + RKT          ET +E  E +  E  +E  +
Sbjct: 1239 -PEPLKCKQVWPKGTKRGLSKWRQNKERKTGFKLNLYTPPETPMEPDEQVTVEEQKETSE 1297

Query: 367  SNEKKNP----QPPEETG-PVLPQEINPQVEEKTQTKPTEKILELPDE--TKPRETHVEF 419
                 +P    +  +ETG  +LPQE N + E      P     E P++   KP E   E 
Sbjct: 1298 GKTSPSPIRIEEEVKETGEALLPQEENRREETCAPVSPNTSPGEKPEDDLIKPEEEEEEE 1357

Query: 420  SKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFL 479
             +E+  E  +            ++P   K        KE   + + +E    +  H E  
Sbjct: 1358 EEEEEEEEEEEGEEEEGGGNVEKDPDGAKSQ-----EKEEPEISTEKEDSARLDDHEEEE 1412

Query: 480  QPLQKLLNVSEECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDET 530
            +  ++  + +E+    D  +S  E +E   EKE  +L +E  + V E+ ET
Sbjct: 1413 EEDEEPSH-NEDHDADDEDDSHMESAEV--EKE--ELPRESFKEVLENQET 1458



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 123/574 (21%), Positives = 208/574 (36%), Gaps = 91/574 (15%)

Query: 13   DEDGELEPERPELPGLHKLYENAEPDTMA-KADSKL-PAEIYQEPQPETEEEDFKEGEPD 70
            +E+ E E E   L      +E  E + ++ +A+S+  PA++    Q + +     E  P 
Sbjct: 999  EEEREAEKEAERLMEQASCWEKEEQEILSTRANSRQSPAKV----QSKNKYLHSPESRPV 1054

Query: 71   SAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETH 130
            + +  QL         ++KES  +   E +    +E + E   E  +  ++ E   +E  
Sbjct: 1055 TGERGQLLE-------LSKESSEEEEEEED----EEEEEEEEEEEEDEEEEEEEEEEEEE 1103

Query: 131  KESDLEPPEEAKP----------------------NVTEDVFLESAMETDPDPVPPTETM 168
            +     PP   KP                       +   V  E+  ET       TE +
Sbjct: 1104 ENIQSSPPRLTKPQSVAIKRKRPFVLKKKRGRKRRRINSSVTTETISET-------TEVL 1156

Query: 169  SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSE-KLGESLEE 227
            +E    +  ER +  LE   E  V E+  +    +     P + +Q    E K     + 
Sbjct: 1157 NEPFDNSDEERPMPQLEPTCEIEVEEDGRKPVLRKAFQHQPGKKRQTEEEEGKDNHCFKN 1216

Query: 228  TDLQPPKMTKPETP-EETQRESTEK---KRTEPPEQARLEFLEKEPRKSSEEAGLEPPEE 283
             D     M    +  +E  +++ E    K+  P    R   L K  +    + G +    
Sbjct: 1217 ADPCRNNMNDDSSNLKEGSKDNPEPLKCKQVWPKGTKR--GLSKWRQNKERKTGFKLNLY 1274

Query: 284  TQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRK 343
            T PE P E   + T E+  E  E      P        +E V E  E +    P+EE+R+
Sbjct: 1275 TPPETPMEPDEQVTVEEQKETSEGKTSPSPIR-----IEEEVKETGEAL---LPQEENRR 1326

Query: 344  TNEETIL----EQSEMMKPE----SPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEE-- 393
              EET        S   KPE     PEE  +  E++  +  EE G    +E    VE+  
Sbjct: 1327 --EETCAPVSPNTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGE--EEEGGGNVEKDP 1382

Query: 394  ---KTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLS 450
               K+Q K   +I    +++   + H E  +ED        +   +++  H E       
Sbjct: 1383 DGAKSQEKEEPEISTEKEDSARLDDHEEEEEEDEEPSHNEDHDADDEDDSHME------- 1435

Query: 451  LSDKFRKEYYALGSLRESEESIGTHYEF-LQPLQKLLNVSEECSYSDPSESQTELSEFVH 509
             S +  KE     S +E  E+  T  +  +QP      V  +C     +   +E  E   
Sbjct: 1436 -SAEVEKEELPRESFKEVLENQETFLDLNVQPGHSNPEVLMDCGVDLTASCNSEPKELAG 1494

Query: 510  EKEVVDLSQEL----KERVSEDDETQPEKGTELQ 539
            + E V  S E     ++   +D +   E  TE +
Sbjct: 1495 DPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFK 1528



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 59/251 (23%), Positives = 109/251 (43%), Gaps = 40/251 (15%)

Query: 34   NAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEG-EPDSAKNVQLKPGGTSQEGIAKESK 92
            N  P    + D   P E  +E + E EEE+ +EG E +   NV+  P G      AK  +
Sbjct: 1336 NTSPGEKPEDDLIKPEEEEEEEEEEEEEEEEEEGEEEEGGGNVEKDPDG------AKSQE 1389

Query: 93   RDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLE 152
            ++     EP I  E   E S  + +  ++ E   + +H E D +  +E      +D  +E
Sbjct: 1390 KE-----EPEISTE--KEDSARLDDHEEEEEEDEEPSHNE-DHDADDE------DDSHME 1435

Query: 153  SAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQT 212
            SA E + + + P E+  E     V E     L+   +PG     + +   + G++     
Sbjct: 1436 SA-EVEKEEL-PRESFKE-----VLENQETFLDLNVQPGHSNPEVLM---DCGVDLTASC 1485

Query: 213  KQDFPSEKLG--ESLEETDLQPP--KMTKPETPEETQRESTEKKRTEPP----EQARLEF 264
              + P E  G  E++ E+D +PP  +  + +  + ++   TE K   P     +   ++ 
Sbjct: 1486 NSE-PKELAGDPEAVPESDEEPPPGEQAQKQDQKNSKEVDTEFKEGNPATMEIDSETVQA 1544

Query: 265  LEKEPRKSSEE 275
            ++   ++SSE+
Sbjct: 1545 VQSLTQESSEQ 1555


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 103/427 (24%), Positives = 173/427 (40%), Gaps = 63/427 (14%)

Query: 5   PEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF 64
           P+  DS    +  ++P+  ++P        A  +T+      LP    +  QP+  E + 
Sbjct: 32  PKQDDSPKSSEETIQPKEGDIP-------KAPEETIQSKKEDLPKSSEKAIQPK--ESNI 82

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
            +    SAK +Q K G   +  +        PS+ + G   +   ET +   E   DL  
Sbjct: 83  PKS---SAKPIQPKLGNIPKASVK-------PSQPKEGDIPKAPEETIQSKKE---DLPK 129

Query: 125 PMDET--HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLE 182
             +E    KE D+ P   AKP   +   L +  +T   P  P E  S++       ++ E
Sbjct: 130 SSEEAIQPKEGDI-PKSSAKPIQPK---LGNIAKTSVKPSQPKE--SDIP------KSPE 177

Query: 183 LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE 242
              +  E  +P+ S +    + G  P    K   P E       E  +QP +   P++ E
Sbjct: 178 ETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 237

Query: 243 ETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGT 302
           E  +   E    + PE+A ++  E +  KS EEA ++P E   P+ PEE      + K  
Sbjct: 238 EAIQPK-EGDIPKSPEEA-IQPKEGDIPKSLEEA-IQPKEGDIPKSPEE----TIQPKKG 290

Query: 303 ELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE 362
           ++P+      P+   +    +    P + I+   P+E     + E  +   E+  P+SPE
Sbjct: 291 DIPKS-----PEEAIQPKEGDIPKSPKQAIQ---PKEGDIPKSLEEAIPPKEIDIPKSPE 342

Query: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKE 422
           E  +  E  +P+  EE  P    +I          KP E+ +E P+  K +   V  SKE
Sbjct: 343 ETIQPKEDDSPKSLEEATPSKEGDI---------LKPEEETMEFPEGDKVK---VILSKE 390

Query: 423 DRPEPIK 429
           D    +K
Sbjct: 391 DFEASLK 397



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/386 (22%), Positives = 160/386 (41%), Gaps = 37/386 (9%)

Query: 53  QEPQPETEEEDF--KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSE 110
           Q+  P++ EE    KEG+   A    ++   + +E + K S++ +  + E  I +     
Sbjct: 34  QDDSPKSSEETIQPKEGDIPKAPEETIQ---SKKEDLPKSSEKAIQPK-ESNIPKSSAKP 89

Query: 111 TSREMGEFFKDLEAPMDETHKESDL-EPPEEAKPNVTEDVFLESAMETDPDPVPPTE-TM 168
              ++G   K    P     KE D+ + PEE   +  ED+      ++  + + P E  +
Sbjct: 90  IQPKLGNIPKASVKPSQP--KEGDIPKAPEETIQSKKEDL-----PKSSEEAIQPKEGDI 142

Query: 169 SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEET 228
            + S   ++ +   + +   +P  P+ES   +  E  ++P E    D P         + 
Sbjct: 143 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEG---DIPKSSAKPIQPKL 199

Query: 229 DLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQP-- 286
              P    KP  P+E     + ++  +P E    + LE+  +    +    P E  QP  
Sbjct: 200 GNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKE 259

Query: 287 -EVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTN 345
            ++P+ ++ +A + K  ++P+  +      +P+K      PE  E I+   P+E     +
Sbjct: 260 GDIPKSLE-EAIQPKEGDIPKSPEETI---QPKKGDIPKSPE--EAIQ---PKEGDIPKS 310

Query: 346 EETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILE 405
            +  ++  E   P+S EE     E   P+ PEET      +    +EE T +K       
Sbjct: 311 PKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEG----- 365

Query: 406 LPDETKPRETHVEFSKEDRPEPIKSK 431
             D  KP E  +EF + D+ + I SK
Sbjct: 366 --DILKPEEETMEFPEGDKVKVILSK 389



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 74/319 (23%), Positives = 128/319 (40%), Gaps = 28/319 (8%)

Query: 137 PPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEES 196
           P ++  P  +E+       +    P  P ET+   S      ++ E   +  E  +P+ S
Sbjct: 32  PKQDDSPKSSEETIQPKEGDI---PKAPEETIQ--SKKEDLPKSSEKAIQPKESNIPKSS 86

Query: 197 LRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET--QRESTEKKRT 254
            +    + G  P    K   P E       E  +Q  K   P++ EE    +E    K +
Sbjct: 87  AKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 146

Query: 255 EPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPD 314
             P Q +L  + K   K S+     P E   P+ PEE      + K  ++P+ +      
Sbjct: 147 AKPIQPKLGNIAKTSVKPSQ-----PKESDIPKSPEE----TIQPKEGDIPKSSA----- 192

Query: 315 HKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQ 374
            KP +    N+P+    +K   P+E     + E  ++  E   P+S EE  +  E   P+
Sbjct: 193 -KPIQPKLGNIPKA--SVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPK 249

Query: 375 PPEETGPVLPQEINPQVEEKTQTKPTEKILELPDET-KPRETHVEFSKEDRPEPIKSKYS 433
            PEE       +I   +EE  Q K  + I + P+ET +P++  +  S E+  +P   +  
Sbjct: 250 SPEEAIQPKEGDIPKSLEEAIQPKEGD-IPKSPEETIQPKKGDIPKSPEEAIQP--KEGD 306

Query: 434 VGNDELEHREPKRGKLSLS 452
           +     +  +PK G +  S
Sbjct: 307 IPKSPKQAIQPKEGDIPKS 325



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 66/292 (22%), Positives = 112/292 (38%), Gaps = 47/292 (16%)

Query: 208 PPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET-----------------QRESTE 250
           P        P +       E  +QP +   P+ PEET                  +ES  
Sbjct: 23  PKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNI 82

Query: 251 KKRTEPPEQARLEFLEK---EPRKSSEEAGLEPPEETQPEVPEEMQR---KATEEKGTEL 304
            K +  P Q +L  + K   +P +  E    + PEET     E++ +   +A + K  ++
Sbjct: 83  PKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDI 142

Query: 305 PERT-KPDFP--------DHKPRKSTDENVPEPLEEI----KLEFPEEESRKTNEETILE 351
           P+ + KP  P          KP +  + ++P+  EE     + + P+  ++    +    
Sbjct: 143 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNI 202

Query: 352 QSEMMKPESPEE--IRKSNE-----KKNPQPPEETGPVLPQE--INPQVEEKTQTKPTEK 402
               +KP  P+E  I KS E     K+   P      + P+E  I    EE  Q K  + 
Sbjct: 203 PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 262

Query: 403 ILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDK 454
              L +  +P+E  +  S E+  +P   K  +     E  +PK G +  S K
Sbjct: 263 PKSLEEAIQPKEGDIPKSPEETIQP--KKGDIPKSPEEAIQPKEGDIPKSPK 312



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/295 (25%), Positives = 123/295 (41%), Gaps = 42/295 (14%)

Query: 256 PPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDH 315
           P   A     +++    S E  ++P E   P+ PEE  +   E+      +  +P    +
Sbjct: 23  PKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPK-ESN 81

Query: 316 KPRKSTDENVPE----PLEEIKLEFPEE-ESRKTNEETILEQSEMMKPESPEEIRKSNEK 370
            P+ S     P+    P   +K   P+E +  K  EETI  + E +   S E I+    K
Sbjct: 82  IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQ---PK 138

Query: 371 KNPQPPEETGPVLPQEINPQVEEKTQTKPTE----KILELPDET-KPRETHVEFSKEDRP 425
           +   P     P+ P+  N     KT  KP++     I + P+ET +P+E  +  S     
Sbjct: 139 EGDIPKSSAKPIQPKLGN---IAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSS---A 192

Query: 426 EPIKSKY-SVGNDELEHREPKRGKLSLSDKFR---KEYYALGSLRESEESIGTHYEFLQP 481
           +PI+ K  ++    ++  +PK G +S S +     KE    G L +S E      E +QP
Sbjct: 193 KPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKE----GDLPKSLE------EAIQP 242

Query: 482 LQKLLNVS-EECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKG 535
            +  +  S EE       +    L E +  KE  D+ +      S ++  QP+KG
Sbjct: 243 KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKE-GDIPK------SPEETIQPKKG 290


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 103/427 (24%), Positives = 173/427 (40%), Gaps = 63/427 (14%)

Query: 5   PEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF 64
           P+  DS    +  ++P+  ++P        A  +T+      LP    +  QP+  E + 
Sbjct: 99  PKQDDSPKSSEETIQPKEGDIP-------KAPEETIQSKKEDLPKSSEKAIQPK--ESNI 149

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
            +    SAK +Q K G   +  +        PS+ + G   +   ET +   E   DL  
Sbjct: 150 PKS---SAKPIQPKLGNIPKASVK-------PSQPKEGDIPKAPEETIQSKKE---DLPK 196

Query: 125 PMDET--HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLE 182
             +E    KE D+ P   AKP   +   L +  +T   P  P E  S++       ++ E
Sbjct: 197 SSEEAIQPKEGDI-PKSSAKPIQPK---LGNIAKTSVKPSQPKE--SDIP------KSPE 244

Query: 183 LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE 242
              +  E  +P+ S +    + G  P    K   P E       E  +QP +   P++ E
Sbjct: 245 ETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 304

Query: 243 ETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGT 302
           E  +   E    + PE+A ++  E +  KS EEA ++P E   P+ PEE      + K  
Sbjct: 305 EAIQPK-EGDIPKSPEEA-IQPKEGDIPKSLEEA-IQPKEGDIPKSPEE----TIQPKKG 357

Query: 303 ELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE 362
           ++P+      P+   +    +    P + I+   P+E     + E  +   E+  P+SPE
Sbjct: 358 DIPKS-----PEEAIQPKEGDIPKSPKQAIQ---PKEGDIPKSLEEAIPPKEIDIPKSPE 409

Query: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKE 422
           E  +  E  +P+  EE  P    +I          KP E+ +E P+  K +   V  SKE
Sbjct: 410 ETIQPKEDDSPKSLEEATPSKEGDI---------LKPEEETMEFPEGDKVK---VILSKE 457

Query: 423 DRPEPIK 429
           D    +K
Sbjct: 458 DFEASLK 464



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/386 (22%), Positives = 160/386 (41%), Gaps = 37/386 (9%)

Query: 53  QEPQPETEEEDF--KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSE 110
           Q+  P++ EE    KEG+   A    ++   + +E + K S++ +  + E  I +     
Sbjct: 101 QDDSPKSSEETIQPKEGDIPKAPEETIQ---SKKEDLPKSSEKAIQPK-ESNIPKSSAKP 156

Query: 111 TSREMGEFFKDLEAPMDETHKESDL-EPPEEAKPNVTEDVFLESAMETDPDPVPPTE-TM 168
              ++G   K    P     KE D+ + PEE   +  ED+      ++  + + P E  +
Sbjct: 157 IQPKLGNIPKASVKPSQP--KEGDIPKAPEETIQSKKEDL-----PKSSEEAIQPKEGDI 209

Query: 169 SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEET 228
            + S   ++ +   + +   +P  P+ES   +  E  ++P E    D P         + 
Sbjct: 210 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEG---DIPKSSAKPIQPKL 266

Query: 229 DLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQP-- 286
              P    KP  P+E     + ++  +P E    + LE+  +    +    P E  QP  
Sbjct: 267 GNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKE 326

Query: 287 -EVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTN 345
            ++P+ ++ +A + K  ++P+  +      +P+K      PE  E I+   P+E     +
Sbjct: 327 GDIPKSLE-EAIQPKEGDIPKSPEETI---QPKKGDIPKSPE--EAIQ---PKEGDIPKS 377

Query: 346 EETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILE 405
            +  ++  E   P+S EE     E   P+ PEET      +    +EE T +K       
Sbjct: 378 PKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEG----- 432

Query: 406 LPDETKPRETHVEFSKEDRPEPIKSK 431
             D  KP E  +EF + D+ + I SK
Sbjct: 433 --DILKPEEETMEFPEGDKVKVILSK 456



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 87/386 (22%), Positives = 148/386 (38%), Gaps = 39/386 (10%)

Query: 83  SQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAK 142
           + EG A ES   V S   P +  E       +   F   +        +ESD     +  
Sbjct: 30  TSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDL 89

Query: 143 PNVTEDVFLESAMETDPDPVPPTETMSEVSG-------ATVRERNLELLE------EETE 189
           P  + +    S  + D  P    ET+    G        T++ +  +L +      +  E
Sbjct: 90  PKSSANT---SHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKE 146

Query: 190 PGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET--QRE 247
             +P+ S +    + G  P    K   P E       E  +Q  K   P++ EE    +E
Sbjct: 147 SNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKE 206

Query: 248 STEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPER 307
               K +  P Q +L  + K   K S+     P E   P+ PEE      + K  ++P+ 
Sbjct: 207 GDIPKSSAKPIQPKLGNIAKTSVKPSQ-----PKESDIPKSPEE----TIQPKEGDIPKS 257

Query: 308 TKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKS 367
           +       KP +    N+P+    +K   P+E     + E  ++  E   P+S EE  + 
Sbjct: 258 SA------KPIQPKLGNIPKA--SVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQP 309

Query: 368 NEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDET-KPRETHVEFSKEDRPE 426
            E   P+ PEE       +I   +EE  Q K  + I + P+ET +P++  +  S E+  +
Sbjct: 310 KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGD-IPKSPEETIQPKKGDIPKSPEEAIQ 368

Query: 427 PIKSKYSVGNDELEHREPKRGKLSLS 452
           P   +  +     +  +PK G +  S
Sbjct: 369 P--KEGDIPKSPKQAIQPKEGDIPKS 392


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 103/427 (24%), Positives = 173/427 (40%), Gaps = 63/427 (14%)

Query: 5   PEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDF 64
           P+  DS    +  ++P+  ++P        A  +T+      LP    +  QP+  E + 
Sbjct: 32  PKQDDSPKSSEETIQPKEGDIP-------KAPEETIQSKKEDLPKSSEKAIQPK--ESNI 82

Query: 65  KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEA 124
            +    SAK +Q K G   +  +        PS+ + G   +   ET +   E   DL  
Sbjct: 83  PKS---SAKPIQPKLGNIPKASVK-------PSQPKEGDIPKAPEETIQSKKE---DLPK 129

Query: 125 PMDET--HKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLE 182
             +E    KE D+ P   AKP   +   L +  +T   P  P E  S++       ++ E
Sbjct: 130 SSEEAIQPKEGDI-PKSSAKPIQPK---LGNIAKTSVKPSQPKE--SDIP------KSPE 177

Query: 183 LLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPE 242
              +  E  +P+ S +    + G  P    K   P E       E  +QP +   P++ E
Sbjct: 178 ETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLE 237

Query: 243 ETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGT 302
           E  +   E    + PE+A ++  E +  KS EEA ++P E   P+ PEE      + K  
Sbjct: 238 EAIQPK-EGDIPKSPEEA-IQPKEGDIPKSLEEA-IQPKEGDIPKSPEE----TIQPKKG 290

Query: 303 ELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPE 362
           ++P+      P+   +    +    P + I+   P+E     + E  +   E+  P+SPE
Sbjct: 291 DIPKS-----PEEAIQPKEGDIPKSPKQAIQ---PKEGDIPKSLEEAIPPKEIDIPKSPE 342

Query: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKE 422
           E  +  E  +P+  EE  P    +I          KP E+ +E P+  K +   V  SKE
Sbjct: 343 ETIQPKEDDSPKSLEEATPSKEGDI---------LKPEEETMEFPEGDKVK---VILSKE 390

Query: 423 DRPEPIK 429
           D    +K
Sbjct: 391 DFEASLK 397



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/386 (22%), Positives = 160/386 (41%), Gaps = 37/386 (9%)

Query: 53  QEPQPETEEEDF--KEGEPDSAKNVQLKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSE 110
           Q+  P++ EE    KEG+   A    ++   + +E + K S++ +  + E  I +     
Sbjct: 34  QDDSPKSSEETIQPKEGDIPKAPEETIQ---SKKEDLPKSSEKAIQPK-ESNIPKSSAKP 89

Query: 111 TSREMGEFFKDLEAPMDETHKESDL-EPPEEAKPNVTEDVFLESAMETDPDPVPPTE-TM 168
              ++G   K    P     KE D+ + PEE   +  ED+      ++  + + P E  +
Sbjct: 90  IQPKLGNIPKASVKPSQP--KEGDIPKAPEETIQSKKEDL-----PKSSEEAIQPKEGDI 142

Query: 169 SEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEET 228
            + S   ++ +   + +   +P  P+ES   +  E  ++P E    D P         + 
Sbjct: 143 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEG---DIPKSSAKPIQPKL 199

Query: 229 DLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQP-- 286
              P    KP  P+E     + ++  +P E    + LE+  +    +    P E  QP  
Sbjct: 200 GNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKE 259

Query: 287 -EVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTN 345
            ++P+ ++ +A + K  ++P+  +      +P+K      PE  E I+   P+E     +
Sbjct: 260 GDIPKSLE-EAIQPKEGDIPKSPEETI---QPKKGDIPKSPE--EAIQ---PKEGDIPKS 310

Query: 346 EETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILE 405
            +  ++  E   P+S EE     E   P+ PEET      +    +EE T +K       
Sbjct: 311 PKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEG----- 365

Query: 406 LPDETKPRETHVEFSKEDRPEPIKSK 431
             D  KP E  +EF + D+ + I SK
Sbjct: 366 --DILKPEEETMEFPEGDKVKVILSK 389



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 74/319 (23%), Positives = 128/319 (40%), Gaps = 28/319 (8%)

Query: 137 PPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEES 196
           P ++  P  +E+       +    P  P ET+   S      ++ E   +  E  +P+ S
Sbjct: 32  PKQDDSPKSSEETIQPKEGDI---PKAPEETIQ--SKKEDLPKSSEKAIQPKESNIPKSS 86

Query: 197 LRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET--QRESTEKKRT 254
            +    + G  P    K   P E       E  +Q  K   P++ EE    +E    K +
Sbjct: 87  AKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSS 146

Query: 255 EPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPD 314
             P Q +L  + K   K S+     P E   P+ PEE      + K  ++P+ +      
Sbjct: 147 AKPIQPKLGNIAKTSVKPSQ-----PKESDIPKSPEE----TIQPKEGDIPKSSA----- 192

Query: 315 HKPRKSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQ 374
            KP +    N+P+    +K   P+E     + E  ++  E   P+S EE  +  E   P+
Sbjct: 193 -KPIQPKLGNIPKA--SVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPK 249

Query: 375 PPEETGPVLPQEINPQVEEKTQTKPTEKILELPDET-KPRETHVEFSKEDRPEPIKSKYS 433
            PEE       +I   +EE  Q K  + I + P+ET +P++  +  S E+  +P   +  
Sbjct: 250 SPEEAIQPKEGDIPKSLEEAIQPKEGD-IPKSPEETIQPKKGDIPKSPEEAIQP--KEGD 306

Query: 434 VGNDELEHREPKRGKLSLS 452
           +     +  +PK G +  S
Sbjct: 307 IPKSPKQAIQPKEGDIPKS 325



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 66/292 (22%), Positives = 112/292 (38%), Gaps = 47/292 (16%)

Query: 208 PPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEET-----------------QRESTE 250
           P        P +       E  +QP +   P+ PEET                  +ES  
Sbjct: 23  PKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNI 82

Query: 251 KKRTEPPEQARLEFLEK---EPRKSSEEAGLEPPEETQPEVPEEMQR---KATEEKGTEL 304
            K +  P Q +L  + K   +P +  E    + PEET     E++ +   +A + K  ++
Sbjct: 83  PKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDI 142

Query: 305 PERT-KPDFP--------DHKPRKSTDENVPEPLEEI----KLEFPEEESRKTNEETILE 351
           P+ + KP  P          KP +  + ++P+  EE     + + P+  ++    +    
Sbjct: 143 PKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNI 202

Query: 352 QSEMMKPESPEE--IRKSNE-----KKNPQPPEETGPVLPQE--INPQVEEKTQTKPTEK 402
               +KP  P+E  I KS E     K+   P      + P+E  I    EE  Q K  + 
Sbjct: 203 PKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDI 262

Query: 403 ILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDK 454
              L +  +P+E  +  S E+  +P   K  +     E  +PK G +  S K
Sbjct: 263 PKSLEEAIQPKEGDIPKSPEETIQP--KKGDIPKSPEEAIQPKEGDIPKSPK 312



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 74/295 (25%), Positives = 123/295 (41%), Gaps = 42/295 (14%)

Query: 256 PPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDH 315
           P   A     +++    S E  ++P E   P+ PEE  +   E+      +  +P    +
Sbjct: 23  PKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPK-ESN 81

Query: 316 KPRKSTDENVPE----PLEEIKLEFPEE-ESRKTNEETILEQSEMMKPESPEEIRKSNEK 370
            P+ S     P+    P   +K   P+E +  K  EETI  + E +   S E I+    K
Sbjct: 82  IPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQ---PK 138

Query: 371 KNPQPPEETGPVLPQEINPQVEEKTQTKPTE----KILELPDET-KPRETHVEFSKEDRP 425
           +   P     P+ P+  N     KT  KP++     I + P+ET +P+E  +  S     
Sbjct: 139 EGDIPKSSAKPIQPKLGN---IAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSS---A 192

Query: 426 EPIKSKY-SVGNDELEHREPKRGKLSLSDKFR---KEYYALGSLRESEESIGTHYEFLQP 481
           +PI+ K  ++    ++  +PK G +S S +     KE    G L +S E      E +QP
Sbjct: 193 KPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKE----GDLPKSLE------EAIQP 242

Query: 482 LQKLLNVS-EECSYSDPSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEKG 535
            +  +  S EE       +    L E +  KE  D+ +      S ++  QP+KG
Sbjct: 243 KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKE-GDIPK------SPEETIQPKKG 290


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 92/449 (20%), Positives = 177/449 (39%), Gaps = 52/449 (11%)

Query: 18  LEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEG-EPDSAKNVQ 76
           L  E P+  G  +     E + +A A+ ++P        P  + E       P  A +  
Sbjct: 363 LNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSP 422

Query: 77  LKPGGTSQEGIAKESKRDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETH--KESD 134
             P    QE  AK  + D P E      Q  + + S      +K   + +DE    ++ +
Sbjct: 423 ETPSAGQQE--AKTDQADGPREPP----QSARRKRS------YKQAVSELDEEQHLEDEE 470

Query: 135 LEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEV-SGATVRERNLELLEEETEPGVP 193
           L+PP    P+                P P ++ +  + +     +RN  L+   + P   
Sbjct: 471 LQPPRSKTPS---------------SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV 515

Query: 194 EESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPKMTKPETPEETQRESTEKKR 253
            +S   ++    ++P E+ +Q   + +  E  E+   Q  +  K    EE + +  E+ R
Sbjct: 516 MKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLR 575

Query: 254 TEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPE-----VPEEMQRKATEEKGTELPERT 308
                + R+E +++E +K  E+   +  E+T+         E+ ++KA  +K  E+  R 
Sbjct: 576 KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 635

Query: 309 KPDFPDHKPR---KSTDENVPEPLEEIKLEFPEEESRKTNEETIL---EQSEMMKPESPE 362
           K +    + R   +  +E   + L + K E  +E  RK  E   L    + E  + E  E
Sbjct: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695

Query: 363 EIRKSNEKKNPQPPEETGPVLPQEINPQVEE---KTQTKPTEKILELPDETKPRETHVEF 419
           + R+  E++  +  E+   +  QE   + E    + + +  EK L L  E   RE   + 
Sbjct: 696 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 755

Query: 420 SKEDRPEPIKSKYSVGNDELEHREPKRGK 448
            KE++         +   +L+  + K+ K
Sbjct: 756 KKEEQQR-------LAERQLQEEQEKKAK 777



 Score = 37.7 bits (86), Expect = 0.035
 Identities = 58/291 (19%), Positives = 117/291 (40%), Gaps = 30/291 (10%)

Query: 126 MDETHKE----SDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNL 181
           MD   KE     +L   EEA+    + V  +     +   +   E + +V  A  RER +
Sbjct: 528 MDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA--RER-V 584

Query: 182 ELLEEETEPGVPEESLRVQHEETGLEPP----EQTKQDFPSEKLGE----SLEETDLQPP 233
           E ++EE +  + ++  ++  +    +      E+ K+   ++K+ E      +E + +  
Sbjct: 585 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL 644

Query: 234 KMTKPETPEETQRESTEKKRTEPPEQAR--------LEFLEKEPRKSSEEAGLEPPEETQ 285
           +  + E  E   +E  +KK+ E  E+ R         E  E+E R+          +E +
Sbjct: 645 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERR 704

Query: 286 PEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKSTDENVPEPLEEIKLEFPEEESRKTN 345
            +   E +R+  E++     ER + +    +  K+      +   E++ +  +EE ++  
Sbjct: 705 EQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLA 764

Query: 346 EETILEQSEMMKPESPEEIRKSNEKKNPQPPEET-------GPVLPQEINP 389
           E  + E+ E    E+    +  N   + Q P  T       G   P +INP
Sbjct: 765 ERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINP 815


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 112/518 (21%), Positives = 195/518 (37%), Gaps = 75/518 (14%)

Query: 33  ENAEPDTMAKADSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPGGTSQEGIAKESK 92
           E  + D+ +K  +K   E+Y       +++DF +  P  AK       G +Q+   K   
Sbjct: 115 ELEDKDSKSKKTAKPKVEMYSGSD---DDDDFNK-LPKKAK-------GKAQKSNKKWDG 163

Query: 93  RDVPSETEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLE 152
            +   +    I +  +  +S E G    D      ++ K        +  PN+      E
Sbjct: 164 SEEDEDNSKKIKERSRINSSGESG----DESDEFLQSRKGQKKNQKNKPGPNI------E 213

Query: 153 SAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEES-LRVQHEETGLEP--P 209
           S  E D          +     TV ++  E  E E +    E++ LR   E+  LE    
Sbjct: 214 SGNEDDD---------ASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKK 264

Query: 210 EQTKQDFPSEKLGESLE------ETDLQPPKMTKPETPE--ETQRESTEKKRTEPPEQAR 261
           +Q+KQ     K  E         +T + P    K ETP   E   E  +KK+ +  ++  
Sbjct: 265 DQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGE 324

Query: 262 LEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKATEEKGTELPERTKPDFPDHKPRKST 321
            E  EKE +K   +A ++  +E   ++ EE +R+  EE+     ER K        RK  
Sbjct: 325 KEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE-----ERIKRLEELEAKRKEE 379

Query: 322 DENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETG- 380
           +    E  E  K +  E + R   E  +L +S+       E   K  + +  + P +   
Sbjct: 380 ERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSL 439

Query: 381 ----PVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGN 436
               P+   +   ++ ++ ++K   + +EL    +  E  V   KE+ P P++       
Sbjct: 440 PKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVP-EKEETPPPVEP------ 492

Query: 437 DELEHREPKRGKLSLSDKFRKEYYALGSLRESEESIGTHYEFLQPLQKLLNVSEECSYSD 496
           +E E  E         D    ++ A+ S  E+E+  G            + V E     +
Sbjct: 493 EEEEDTE---------DAGLDDWEAMASDEETEKVEGNKVH--------IEVKENPEEEE 535

Query: 497 PSESQTELSEFVHEKEVVDLSQELKERVSEDDETQPEK 534
             E + E  E   E+E  +   E  E   ED++   EK
Sbjct: 536 EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEK 573



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 86/400 (21%), Positives = 157/400 (39%), Gaps = 50/400 (12%)

Query: 174 ATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPP 233
           +T  + +L+ L  E E G      +   +  G +  E+ KQDF  + + + LEE  L+  
Sbjct: 12  STKDDIDLDALAAEIE-GAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ 70

Query: 234 KMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQ 293
            +       +  RE+   K TE  E+   EF  K+ +K  ++   +  ++   E  E+  
Sbjct: 71  GI-------KADRETVAVKPTENNEE---EFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120

Query: 294 RKA--TEEKGTELPERTKPDFPDHK-PRKSTDENVPEPLEEIKLEFPEEESRKTNEETIL 350
            K+  T +   E+   +  D   +K P+K+  +      +    E  E+ S+K  E + +
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180

Query: 351 EQSEMMKPESPEEI-----RKSNEKKNPQPPEETG------------------PVLPQEI 387
             S     ES E +     +K N+K  P P  E+G                      +E 
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERER 240

Query: 388 NPQVEEKTQTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRG 447
             + EEK + +  ++  EL    K +    E  ++   E +KSK +V    +   E K  
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300

Query: 448 KLSLSD---------KFRKEYYALGSLRESEESIGTHYEFLQPLQKL---LNVSEECSYS 495
             + ++         K +K+       +E E+  G     ++ +Q+    L   EE    
Sbjct: 301 TPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR 360

Query: 496 DPSESQTELSEF-VHEKEVVDLSQELKERVSEDDETQPEK 534
           +  E    L E     KE   L QE +ER  + ++ + E+
Sbjct: 361 EEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKER 400



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 105/478 (21%), Positives = 174/478 (36%), Gaps = 76/478 (15%)

Query: 44  DSKLPAEIYQEPQPETEEEDFKEGEPDSAKNVQLKPG-----GTSQEGIAKESKRDVPSE 98
           D+    +   + + E +E + K+ + + AK  +LK       G   +   KES+R    E
Sbjct: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279

Query: 99  TEPGIHQEVKSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESA-MET 157
           T       VKS+ + + G      E     T  E D E  ++ K    +    E    E 
Sbjct: 280 T-------VKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332

Query: 158 DPDPVPPTETMSEVSGATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFP 217
              P   T    + + A ++E       EE E     E L  + +E   E  EQ K++  
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEE--ERLEQEKRERK 390

Query: 218 SEKLGESLEETDLQPPKMTKPETPEETQREST-------------------------EKK 252
            +K  E  E    +   +TK +     + E+T                         +KK
Sbjct: 391 KQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKK 450

Query: 253 RTEPPEQARLEFLEKEPRKSSE--------EAGLEPPEETQPEVPEEMQRKATEEKGTEL 304
           R + P+Q       KE  +S E        E G+   EET P V  E + + TE+ G + 
Sbjct: 451 RKKIPQQLE----SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE-EEEDTEDAGLDD 505

Query: 305 PERTKPDFPDHKPR-KSTDENVPEPLEEIKLEFPEEESRKTNEETILEQSEMMKPESPEE 363
            E    D    K         V E  EE + E  EEE  + +EE   E+ E    E  EE
Sbjct: 506 WEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEE 565

Query: 364 IRKSNEKKNPQPPEETGPVLPQEINPQVEEKTQTKPTEKILELPDETKPRETHVEFSKED 423
             K +++K      ++G  L ++ + ++   ++    +      D TK    + +  +  
Sbjct: 566 DEKVSDEK------DSGKTLDKKPSKEMSSDSEYDSDD------DRTKEERAYDKAKRRI 613

Query: 424 RPEPIKSKYSVGNDELEHREP--------KRGKLSLSDKFRKEYYALGSLRESEESIG 473
               ++   +V  ++L  R P          GK  + DK R  +   G      + IG
Sbjct: 614 EKRRLEHSKNVNTEKL--RAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIG 669



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 66/298 (22%), Positives = 114/298 (38%), Gaps = 30/298 (10%)

Query: 1   MAEVPEDYDSGPDEDGELEPERPELPGLHKLYENAEPDTMAKADSKLPAEIYQEPQPETE 60
           +A++ E+ +    E+ E      EL    K  E  E +   +   K         + E +
Sbjct: 348 LAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQK---------EKERK 398

Query: 61  EEDFKEGE--PDSAKNVQLKPGGTSQ----EGIAKESKRDVPSET-------EPGIHQEV 107
           E   KEG+    S +  + +   T +    +G+   SK  +P +           I Q++
Sbjct: 399 ERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQL 458

Query: 108 KSETSREMGEFFKDLEAPMDETHKESDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTET 167
           +S+   E  E    +E       ++ +  PP E  P   ED   E A   D + +   E 
Sbjct: 459 ESKEVSESMELCAAVEVMEQGVPEKEETPPPVE--PEEEEDT--EDAGLDDWEAMASDEE 514

Query: 168 MSEVSG----ATVRERNLELLEEETEPGVPEESLRVQHEETGLEPPEQTKQDFPSEKLGE 223
             +V G      V+E   E  EEE E    EES   + EE   E  E  ++D       +
Sbjct: 515 TEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKD 574

Query: 224 SLEETDLQPPKMTKPETPEETQRESTEKKRTEPPEQARLEFLEKEPRKSSEEAGLEPP 281
           S +  D +P K    ++  ++  + T+++R     + R+E    E  K+     L  P
Sbjct: 575 SGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAP 632


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.303    0.127    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,860,504
Number of Sequences: 37866
Number of extensions: 1905473
Number of successful extensions: 14170
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 214
Number of HSP's successfully gapped in prelim test: 1367
Number of HSP's that attempted gapping in prelim test: 7291
Number of HSP's gapped (non-prelim): 4720
length of query: 674
length of database: 18,247,518
effective HSP length: 109
effective length of query: 565
effective length of database: 14,120,124
effective search space: 7977870060
effective search space used: 7977870060
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.