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Search of human proteins with 57529246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
(1318 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 2692 0.0
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 399 e-110
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 399 e-110
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 390 e-108
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 383 e-106
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 199 2e-50
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 198 2e-50
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 179 1e-44
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 179 1e-44
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 179 1e-44
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 153 9e-37
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 150 8e-36
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 149 2e-35
gi|148612811 ubiquitin specific protease 43 [Homo sapiens] 126 2e-28
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 124 5e-28
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 124 5e-28
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 101 5e-21
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 96 2e-19
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 96 2e-19
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 96 2e-19
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 95 5e-19
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 95 5e-19
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 95 5e-19
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 91 7e-18
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 90 1e-17
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 89 4e-17
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 87 1e-16
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 87 1e-16
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 87 1e-16
gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens] 81 6e-15
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 2692 bits (6978), Expect = 0.0
Identities = 1318/1318 (100%), Positives = 1318/1318 (100%)
Query: 1 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD 60
MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD
Sbjct: 1 MSGGASATGPRRGPPGLEDTTSKKKQKDRANQESKDGDPRKETGSRYVAQAGLEPLASGD 60
Query: 61 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW 120
PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW
Sbjct: 61 PSASASHAAGITGSRHRTRLFFPSSSGSASTPQEEQTKEGACEDPHDLLATPTPELLLDW 120
Query: 121 RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR 180
RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR
Sbjct: 121 RQSAEEVIVKLRVGVGPLQLEDVDAAFTDTDCVVRFAGGQQWGGVFYAEIKSSCAKVQTR 180
Query: 181 KGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN 240
KGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN
Sbjct: 181 KGSLLHLTLPKKVPMLTWPSLLVEADEQLCIPPLNSQTCLLGSEENLAPLAGEKAVPPGN 240
Query: 241 DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH 300
DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH
Sbjct: 241 DPVSPAMVRSRNPGKDDCAKEEMAVAADAATLVDEPESMVNLAFVKNDSYEKGPDSVVVH 300
Query: 301 VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT 360
VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT
Sbjct: 301 VYVKEICRDTSRVLFREQDFTLIFQTRDGNFLRLHPGCGPHTTFRWQVKLRNLIEPEQCT 360
Query: 361 FCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE 420
FCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE
Sbjct: 361 FCFTASRIDICLRKRQSQRWGGLEAPAARVGGAKVAVPTGPTPLDSTPPGGAPHPLTGQE 420
Query: 421 EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDS 480
EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDS
Sbjct: 421 EARAVEKDKSKARSEDTGLDSVATRTPMEHVTPKPETHLASPKPTCMVPPMPHSPVSGDS 480
Query: 481 VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL 540
VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL
Sbjct: 481 VEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPL 540
Query: 541 GTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL 600
GTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL
Sbjct: 541 GTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL 600
Query: 601 HEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCA 660
HEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCA
Sbjct: 601 HEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCA 660
Query: 661 KVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQS 720
KVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQS
Sbjct: 661 KVSITFDPFLYLPVPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQS 720
Query: 721 VHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQR 780
VHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQR
Sbjct: 721 VHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQR 780
Query: 781 PQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGY 840
PQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGY
Sbjct: 781 PQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGY 840
Query: 841 PFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEA 900
PFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEA
Sbjct: 841 PFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTGSLEA 900
Query: 901 GDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLP 960
GDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLP
Sbjct: 901 GDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLP 960
Query: 961 AGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLA 1020
AGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLA
Sbjct: 961 AGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLA 1020
Query: 1021 LVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWY 1080
LVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWY
Sbjct: 1021 LVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWY 1080
Query: 1081 CPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140
CPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG
Sbjct: 1081 CPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140
Query: 1141 QKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQ 1200
QKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQ
Sbjct: 1141 QKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQ 1200
Query: 1201 VVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPE 1260
VVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPE
Sbjct: 1201 VVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAASQASRIWQELEAEEEPVPE 1260
Query: 1261 GSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR 1318
GSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR
Sbjct: 1261 GSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPLVSQSRWR 1318
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 399 bits (1024), Expect = e-110
Identities = 266/739 (35%), Positives = 370/739 (50%), Gaps = 106/739 (14%)
Query: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553
PG GL NLGNTCFMNS +Q LSNT L D+F +EAEIN +NPLG G +A +A L
Sbjct: 299 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 358
Query: 554 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613
++ +W G P K V A QF+GY Q D+QE +AFLLDGLHEDLNR++ KPY
Sbjct: 359 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 614 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673
E D++GRPD VVA+EAW+ H++RNDS IVD F G +KS LVCP CAKVS+TFDPF YL
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
Query: 674 VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732
+PLP +K +V+ VF +PH +P ++ V+V + S++ ++LS+ + EN+ +A+
Sbjct: 479 LPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGA-VSDLCEALSRLSGIAAENMVVAD 537
Query: 733 VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792
V +RFH++F L+ + P D + +E+ S+ + V L V
Sbjct: 538 VYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVY-------------- 583
Query: 793 ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852
R+++S + Y G P L+SVP +LT
Sbjct: 584 --FRERKSRPSSTSSASALY--------------------------GQPLLLSVPKHKLT 615
Query: 853 YARLAQLLEGYARYSVSVFQP-PFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPP 911
L Q + R S V QP P + G LE PG S S E D E
Sbjct: 616 LESLYQAV--CDRISRYVKQPLPDEFGSSPLE---PGACN-GSRNSCEGEDEEE------ 663
Query: 912 ELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAA 971
+ EG L SE SG E G+ P+ +
Sbjct: 664 ----MEHQEEGKEQL-------------------SETEGSGEDEPGNDPS----ETTQKK 696
Query: 972 VPGYQHPSEAMN-AHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQ 1030
+ G P + + I+S + +L L+L +LA+ W + R
Sbjct: 697 IKGQPCPKRLFTFSLVNSYGTADINSLAADGKL-------LKLNSRSTLAMDWDSETRR- 748
Query: 1031 EFVLVASKELECAEDPGSAGEAARAGHFT--LDQCLNLFTRPEVLAPEEAWYCPQCKQHR 1088
+ +E E E S + + T L C+ LFT E L + WYCP CK+H+
Sbjct: 749 --LYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQ 806
Query: 1089 EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS 1148
+A+K+ LW LP +L+V LKRFS+ + WRDK++ +VEFP+R L++S+F
Sbjct: 807 QATKKFDLWSLPKILVVHLKRFSYNRY-WRDKLDTVVEFPIRGLNMSEFVCNLSARPY-V 864
Query: 1149 YDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYV 1208
YDL AV NHYG M GHYTA A+ + + W FDDS V+ E Q+VT+ AYV
Sbjct: 865 YDLIAVSNHYGAMGVGHYTAYAK-------NKLNGKWYYFDDSNVSLASEDQIVTKAAYV 917
Query: 1209 LFYRRRNSPVERPPRAGHS 1227
LFY+RR+ + P S
Sbjct: 918 LFYQRRDDEFYKTPSLSSS 936
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 399 bits (1024), Expect = e-110
Identities = 266/739 (35%), Positives = 370/739 (50%), Gaps = 106/739 (14%)
Query: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553
PG GL NLGNTCFMNS +Q LSNT L D+F +EAEIN +NPLG G +A +A L
Sbjct: 252 PGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAEL 311
Query: 554 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613
++ +W G P K V A QF+GY Q D+QE +AFLLDGLHEDLNR++ KPY
Sbjct: 312 IKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 614 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673
E D++GRPD VVA+EAW+ H++RNDS IVD F G +KS LVCP CAKVS+TFDPF YL
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
Query: 674 VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732
+PLP +K +V+ VF +PH +P ++ V+V + S++ ++LS+ + EN+ +A+
Sbjct: 432 LPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGA-VSDLCEALSRLSGIAAENMVVAD 490
Query: 733 VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792
V +RFH++F L+ + P D + +E+ S+ + V L V
Sbjct: 491 VYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVY-------------- 536
Query: 793 ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852
R+++S + Y G P L+SVP +LT
Sbjct: 537 --FRERKSRPSSTSSASALY--------------------------GQPLLLSVPKHKLT 568
Query: 853 YARLAQLLEGYARYSVSVFQP-PFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPP 911
L Q + R S V QP P + G LE PG S S E D E
Sbjct: 569 LESLYQAV--CDRISRYVKQPLPDEFGSSPLE---PGACN-GSRNSCEGEDEEE------ 616
Query: 912 ELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAA 971
+ EG L SE SG E G+ P+ +
Sbjct: 617 ----MEHQEEGKEQL-------------------SETEGSGEDEPGNDPS----ETTQKK 649
Query: 972 VPGYQHPSEAMN-AHTPQFFIYKIDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQ 1030
+ G P + + I+S + +L L+L +LA+ W + R
Sbjct: 650 IKGQPCPKRLFTFSLVNSYGTADINSLAADGKL-------LKLNSRSTLAMDWDSETRR- 701
Query: 1031 EFVLVASKELECAEDPGSAGEAARAGHFT--LDQCLNLFTRPEVLAPEEAWYCPQCKQHR 1088
+ +E E E S + + T L C+ LFT E L + WYCP CK+H+
Sbjct: 702 --LYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQ 759
Query: 1089 EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS 1148
+A+K+ LW LP +L+V LKRFS+ + WRDK++ +VEFP+R L++S+F
Sbjct: 760 QATKKFDLWSLPKILVVHLKRFSYNRY-WRDKLDTVVEFPIRGLNMSEFVCNLSARPY-V 817
Query: 1149 YDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYV 1208
YDL AV NHYG M GHYTA A+ + + W FDDS V+ E Q+VT+ AYV
Sbjct: 818 YDLIAVSNHYGAMGVGHYTAYAK-------NKLNGKWYYFDDSNVSLASEDQIVTKAAYV 870
Query: 1209 LFYRRRNSPVERPPRAGHS 1227
LFY+RR+ + P S
Sbjct: 871 LFYQRRDDEFYKTPSLSSS 889
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 390 bits (1003), Expect = e-108
Identities = 267/783 (34%), Positives = 383/783 (48%), Gaps = 117/783 (14%)
Query: 470 PMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRS 529
P V +++ EE+E+ K PG GL NLGNTCFMNS +Q LSN +L ++F +
Sbjct: 284 PSAQLHVMNNNMSEEDEDFKGQ--PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNC 341
Query: 530 FEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDA 589
+ E+N+ NPLG G +A +A L++ W G H + P K V ASQF GY QHD+
Sbjct: 342 YLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDS 401
Query: 590 QEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQ 649
QE ++FLLDGLHEDLNR++ K Y E D+ GRPD+ VA+EAWQ HK RNDS IVD F G
Sbjct: 402 QELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGL 461
Query: 650 YKSKLVCPVCAKVSITFDPFLYLPVPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENS 708
+KS LVCP C VS+TFDPF YL VPLP ++VL VF+ +P KP + + V K+
Sbjct: 462 FKSTLVCPDCGNVSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGK 521
Query: 709 TASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL---LSS 765
S++ +LS+ + PE + +A+V +RF++++ L ++ D + +E+ + +
Sbjct: 522 -ISDLCVALSKHTGISPERMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEA 580
Query: 766 ELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTH 825
+V+ V R + P+ R Y Y +
Sbjct: 581 IEGSREDIVVPVYLRERTPA------------------------RDYNNSYYGLML---- 612
Query: 826 WPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQ 885
G+P LVSVP R T+ L +L Y +S +
Sbjct: 613 ------------FGHPLLVSVPRDRFTWEGLYNVL----MYRLSRY-------------- 642
Query: 886 SPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGIS 945
T ++ + GD + D + + + P G R P P +G S
Sbjct: 643 ----VTKPNSDDEDDGDEKEDDEEDKD-DVPGPSTGGSL----------RDPEPEQAGPS 687
Query: 946 SEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLED 1005
S + P + + + Q P Q F + +SN D
Sbjct: 688 SGVTNRCPFLL------------DNCLGTSQWPP---RRRRKQLFTLQTVNSN---GTSD 729
Query: 1006 KGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLN 1065
+ +P E+ +A+ W + + + V E E G + L +C+
Sbjct: 730 RTTSPEEVHAQPYIAIDWEPEMKKRYYDEV---EAEGYVKHDCVGYVMKKAPVRLQECIE 786
Query: 1066 LFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLV 1125
LFT E L E WYCP CKQH+ A+K+L LW LP +LI+ LKRFS+ F R+K++ LV
Sbjct: 787 LFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFS-REKLDTLV 845
Query: 1126 EFPVRNLDLSKFCIGQKEEQLP---SYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSD 1182
EFP+R+LD S+F I + E P YDL AV NHYGGM GHYT A N S Q
Sbjct: 846 EFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFA--CNKDSGQ--- 900
Query: 1183 VGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAGHSEHHPDLGPAAEAAAS 1242
W FDD++V+ V+E+Q+ ++ AYVLFY+R++ AG S PA+ A +S
Sbjct: 901 --WHYFDDNSVSPVNENQIESKAAYVLFYQRQDVARRLLSPAGSSG-----APASPACSS 953
Query: 1243 QAS 1245
S
Sbjct: 954 PPS 956
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 383 bits (984), Expect = e-106
Identities = 250/739 (33%), Positives = 372/739 (50%), Gaps = 105/739 (14%)
Query: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVL 553
PG GL NLGNTCFMNS IQ LSNT L ++F + ++ E+N++NPLG G +A +A L
Sbjct: 257 PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAEL 316
Query: 554 LRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613
++ +W G P K V A QF+GY Q D QE +AFLLDGLHEDLNRI+ KPY
Sbjct: 317 IKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYI 376
Query: 614 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673
+ D+DGRPD+VVAEEAW+ H RNDS IVD+F G +KS LVCP CAK+S+TFDPF YL
Sbjct: 377 QLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLT 436
Query: 674 VPLP-QKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAE 732
+PLP +K++ L V+ +P +KP+++ V V K + ++ +LS + + + + +
Sbjct: 437 LPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNIL-DLCTALSALSGIPADKMIVTD 495
Query: 733 VIKNRFHRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCA 792
+ +RFHR+F ++D E LSS + ++ + V E+
Sbjct: 496 IYNHRFHRIF----AMD-----------ENLSSIMERDDIYVFEIN-------------- 526
Query: 793 ACQRKQQSEDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLT 852
R + +E + C R + + + + H G G PFL++VP +
Sbjct: 527 -INRTEDTEHVIIPVCLR--------EKFRHSSYTHHTG---SSLFGQPFLMAVPRNNTE 574
Query: 853 YARLAQLLEGYARYSVSVFQPPFQPGRMA------LESQSP-GCTTLLSTGSLEAGDSER 905
LL RY + G + + P G S +E + +
Sbjct: 575 DKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNGPNGIHEEGSPSEMETDEPDD 634
Query: 906 DPIQPPELQLVTPMAEGDTGLPRVWAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERV 965
+ Q EL ++ + + G S +G+ +E G +
Sbjct: 635 ESSQDQELPSENENSQSEDSVG--------GDNDSENGLCTEDTCKGQL----------- 675
Query: 966 SRPEAAVPGYQHPSEAMNAHTPQFFIYKIDSSNREQRLEDKGDT--------PLELGDDC 1017
H + F ++ ++ K DT L L +
Sbjct: 676 -----------------TGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERS 718
Query: 1018 SLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEE 1077
LAL W + + + F A+++ E E + + L C+ LFT E L E+
Sbjct: 719 FLALDWDPDLKKRYFDENAAEDFEKHESVEY--KPPKKPFVKLKDCIELFTTKEKLGAED 776
Query: 1078 AWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKF 1137
WYCP CK+H++A+K+L LW LP VL+V LKRFS+ ++ RDK++ LV+FP+ +LD+S+F
Sbjct: 777 PWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYM-RDKLDTLVDFPINDLDMSEF 835
Query: 1138 CIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVD 1197
I Y+L AV NHYGGM GGHYTA A+ + D W FDDS+V+T
Sbjct: 836 LINPNAGPC-RYNLIAVSNHYGGMGGGHYTAFAK-------NKDDGKWYYFDDSSVSTAS 887
Query: 1198 ESQVVTRYAYVLFYRRRNS 1216
E Q+V++ AYVLFY+R+++
Sbjct: 888 EDQIVSKAAYVLFYQRQDT 906
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 199 bits (505), Expect = 2e-50
Identities = 112/272 (41%), Positives = 152/272 (55%), Gaps = 10/272 (3%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G TGL NLGNTCFMNS IQ +SNT+ L +F E+N NP+G G +A + L+
Sbjct: 732 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 791
Query: 555 RALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTE 614
+ LW GT P KL+ +A A +F G+ Q D+QE +AFLLDGLHEDLNR+ KPY E
Sbjct: 792 QELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 851
Query: 615 TVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPV 674
DSDGRPD VA EAW H RN S +VDLF GQ +S++ C C +S+ FDPF +L +
Sbjct: 852 LKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
Query: 675 PLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEV- 733
PLP + + + P+++ + ++ + + LS + E + LAEV
Sbjct: 912 PLPMDSYMHLEITVIKLDGTTPVRYGLRLNMDEKYTG-LKKQLSDLCGLNSEQILLAEVH 970
Query: 734 ---IKNRFHRVFLPSHSLDTVSPSDTLLCFEL 762
IKN F + +S S L FE+
Sbjct: 971 GSNIKN-----FPQDNQKVRLSVSGFLCAFEI 997
Score = 74.3 bits (181), Expect = 7e-13
Identities = 39/87 (44%), Positives = 51/87 (58%), Gaps = 1/87 (1%)
Query: 1053 ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSF 1112
A+A LD CL FT E L E +YC +CK H A+K+L LWRLP +LI+ LKRF F
Sbjct: 1228 AQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQF 1287
Query: 1113 RSFIWRDKINDLVEFPVRNLDLSKFCI 1139
+ W K +V+FP + D S F +
Sbjct: 1288 VNGRW-IKSQKIVKFPRESFDPSAFLV 1313
Score = 46.2 bits (108), Expect = 2e-04
Identities = 23/68 (33%), Positives = 37/68 (54%), Gaps = 8/68 (11%)
Query: 1147 PSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYA 1206
P Y+LYA+ H G + GGHY A+ PN + W ++DS+ + ++ T A
Sbjct: 1508 PIYNLYAISCHSGILGGGHYVTYAKNPNCK--------WYCYNDSSCKELHPDEIDTDSA 1559
Query: 1207 YVLFYRRR 1214
Y+LFY ++
Sbjct: 1560 YILFYEQQ 1567
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 198 bits (504), Expect = 2e-50
Identities = 96/183 (52%), Positives = 120/183 (65%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G TGL NLGNTCFMNS IQ +SNT+ L +F E+N NP+G G +A + L+
Sbjct: 530 GATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLV 589
Query: 555 RALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTE 614
+ LW GT + P KL+ +A A +F G+ Q D+QE +AFLLDGLHEDLNR+ KPY E
Sbjct: 590 QELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE 649
Query: 615 TVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPV 674
DSDGRPD VA EAW H RN S IVDLF GQ +S++ C C +S+ FDPF +L +
Sbjct: 650 LKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 709
Query: 675 PLP 677
PLP
Sbjct: 710 PLP 712
Score = 68.6 bits (166), Expect = 4e-11
Identities = 38/87 (43%), Positives = 48/87 (55%), Gaps = 1/87 (1%)
Query: 1053 ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSF 1112
A+A LD CL FT E L E +YC +CK H A+K+L LWRLP LI+ LKRF F
Sbjct: 1026 AQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQF 1085
Query: 1113 RSFIWRDKINDLVEFPVRNLDLSKFCI 1139
+ W K +V F + D S F +
Sbjct: 1086 VNDQW-IKSQKIVRFLRESFDPSAFLV 1111
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/68 (33%), Positives = 37/68 (54%), Gaps = 8/68 (11%)
Query: 1147 PSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYA 1206
P Y+LYA+ H G + GGHY A+ PN + W ++DS+ + ++ T A
Sbjct: 1310 PIYNLYAISCHSGILSGGHYITYAKNPNCK--------WYCYNDSSCEELHPDEIDTDSA 1361
Query: 1207 YVLFYRRR 1214
Y+LFY ++
Sbjct: 1362 YILFYEQQ 1369
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 179 bits (455), Expect = 1e-44
Identities = 108/280 (38%), Positives = 144/280 (51%), Gaps = 13/280 (4%)
Query: 406 STPPGGAPHPLTGQEEARAVEKDKSKARSEDT--GLDSVATRTPMEHVTPKPETHLASPK 463
STPP P E R K K S D + R P VTP T K
Sbjct: 691 STPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPT--VTP---TVNRENK 745
Query: 464 PTCMVPPMPHSPVSGDSVEEEEEEEKKV--CLPGFTGLVNLGNTCFMNSVIQSLSNTREL 521
PTC P + +S S + P TGL NLGNTC+MNS++Q L N L
Sbjct: 746 PTCY----PKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHL 801
Query: 522 RDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQF 581
D+F+ ++ +IN +N LG G +A F ++++ALW G + P K + QF
Sbjct: 802 ADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQF 861
Query: 582 TGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSF 641
GY+Q D+QE + FL+DGLHEDLN+ N+ + ++D D AE AWQ+HK N+S
Sbjct: 862 AGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESI 921
Query: 642 IVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQK 681
IV LFQGQ+KS + C C K S TF+ F+YL +PL K
Sbjct: 922 IVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSK 961
Score = 131 bits (330), Expect = 4e-30
Identities = 81/232 (34%), Positives = 123/232 (53%), Gaps = 28/232 (12%)
Query: 996 SSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVA------SKELEC--AEDPG 1047
+ NR++ E+ D L D + W+ +++L E ++VA ++C
Sbjct: 887 ADNRKRYKEENND---HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKS 943
Query: 1048 SAGEA--------ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRL 1099
EA A TL CL LF++ E L +YC C+ R++ K++ +W+L
Sbjct: 944 RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKL 1003
Query: 1100 PNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYG 1159
P VL+V LKRFS+ W+ K+ V+FP+ NLDLS++ IG K L Y+L++V NHYG
Sbjct: 1004 PPVLLVHLKRFSYDG-RWKQKLQTSVDFPLENLDLSQYVIGPK-NNLKKYNLFSVSNHYG 1061
Query: 1160 GMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFY 1211
G+ GGHYTA + + + QR W FDD V+ + S V + AY+LFY
Sbjct: 1062 GLDGGHYTAYCK---NAARQR----WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 179 bits (455), Expect = 1e-44
Identities = 108/280 (38%), Positives = 144/280 (51%), Gaps = 13/280 (4%)
Query: 406 STPPGGAPHPLTGQEEARAVEKDKSKARSEDT--GLDSVATRTPMEHVTPKPETHLASPK 463
STPP P E R K K S D + R P VTP T K
Sbjct: 691 STPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPT--VTP---TVNRENK 745
Query: 464 PTCMVPPMPHSPVSGDSVEEEEEEEKKV--CLPGFTGLVNLGNTCFMNSVIQSLSNTREL 521
PTC P + +S S + P TGL NLGNTC+MNS++Q L N L
Sbjct: 746 PTCY----PKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHL 801
Query: 522 RDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQF 581
D+F+ ++ +IN +N LG G +A F ++++ALW G + P K + QF
Sbjct: 802 ADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQF 861
Query: 582 TGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSF 641
GY+Q D+QE + FL+DGLHEDLN+ N+ + ++D D AE AWQ+HK N+S
Sbjct: 862 AGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESI 921
Query: 642 IVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQK 681
IV LFQGQ+KS + C C K S TF+ F+YL +PL K
Sbjct: 922 IVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSK 961
Score = 131 bits (330), Expect = 4e-30
Identities = 81/232 (34%), Positives = 123/232 (53%), Gaps = 28/232 (12%)
Query: 996 SSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVA------SKELEC--AEDPG 1047
+ NR++ E+ D L D + W+ +++L E ++VA ++C
Sbjct: 887 ADNRKRYKEENND---HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKS 943
Query: 1048 SAGEA--------ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRL 1099
EA A TL CL LF++ E L +YC C+ R++ K++ +W+L
Sbjct: 944 RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKL 1003
Query: 1100 PNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYG 1159
P VL+V LKRFS+ W+ K+ V+FP+ NLDLS++ IG K L Y+L++V NHYG
Sbjct: 1004 PPVLLVHLKRFSYDG-RWKQKLQTSVDFPLENLDLSQYVIGPK-NNLKKYNLFSVSNHYG 1061
Query: 1160 GMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFY 1211
G+ GGHYTA + + + QR W FDD V+ + S V + AY+LFY
Sbjct: 1062 GLDGGHYTAYCK---NAARQR----WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 179 bits (455), Expect = 1e-44
Identities = 108/280 (38%), Positives = 144/280 (51%), Gaps = 13/280 (4%)
Query: 406 STPPGGAPHPLTGQEEARAVEKDKSKARSEDT--GLDSVATRTPMEHVTPKPETHLASPK 463
STPP P E R K K S D + R P VTP T K
Sbjct: 691 STPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPT--VTP---TVNRENK 745
Query: 464 PTCMVPPMPHSPVSGDSVEEEEEEEKKV--CLPGFTGLVNLGNTCFMNSVIQSLSNTREL 521
PTC P + +S S + P TGL NLGNTC+MNS++Q L N L
Sbjct: 746 PTCY----PKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHL 801
Query: 522 RDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQF 581
D+F+ ++ +IN +N LG G +A F ++++ALW G + P K + QF
Sbjct: 802 ADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQF 861
Query: 582 TGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSF 641
GY+Q D+QE + FL+DGLHEDLN+ N+ + ++D D AE AWQ+HK N+S
Sbjct: 862 AGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESI 921
Query: 642 IVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQK 681
IV LFQGQ+KS + C C K S TF+ F+YL +PL K
Sbjct: 922 IVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSK 961
Score = 131 bits (330), Expect = 4e-30
Identities = 81/232 (34%), Positives = 123/232 (53%), Gaps = 28/232 (12%)
Query: 996 SSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVA------SKELEC--AEDPG 1047
+ NR++ E+ D L D + W+ +++L E ++VA ++C
Sbjct: 887 ADNRKRYKEENND---HLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKS 943
Query: 1048 SAGEA--------ARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRL 1099
EA A TL CL LF++ E L +YC C+ R++ K++ +W+L
Sbjct: 944 RTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKL 1003
Query: 1100 PNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYG 1159
P VL+V LKRFS+ W+ K+ V+FP+ NLDLS++ IG K L Y+L++V NHYG
Sbjct: 1004 PPVLLVHLKRFSYDG-RWKQKLQTSVDFPLENLDLSQYVIGPK-NNLKKYNLFSVSNHYG 1061
Query: 1160 GMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFY 1211
G+ GGHYTA + + + QR W FDD V+ + S V + AY+LFY
Sbjct: 1062 GLDGGHYTAYCK---NAARQR----WFKFDDHEVSDISVSSVKSSAAYILFY 1106
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 153 bits (387), Expect = 9e-37
Identities = 87/232 (37%), Positives = 125/232 (53%), Gaps = 9/232 (3%)
Query: 455 PETHLASPKPTCMVPPMPHSPVSGDSVEEE------EEEEKKVCLPGFTGLVNLGNTCFM 508
PE A+P P P SP+S + + + G GL NLGNTCFM
Sbjct: 10 PEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFM 69
Query: 509 NSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGT-HHAFQP 567
NS++Q LSNTRELRD+ R + ++++ + T L FA L++ +W + + P
Sbjct: 70 NSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTA--LVEEFAKLIQTIWTSSPNDVVSP 127
Query: 568 SKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVA 627
S+ K + A +F GY Q DAQEF+ FLLDGLH ++NR+ +P + + D PD+
Sbjct: 128 SEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKG 187
Query: 628 EEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQK 679
+ W+++ R DS I DLF GQ KS L C C S FDPF L +P+ ++
Sbjct: 188 RQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 239
Score = 109 bits (272), Expect = 2e-23
Identities = 63/159 (39%), Positives = 87/159 (54%), Gaps = 10/159 (6%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL C+ LFT+ +VL +E C +C+ + K+ + R P +L++ LKRFS S I
Sbjct: 245 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS-ESRIRT 303
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
K+ V FP+R+LDL +F + Y+LYAV NH G +GGHYTA R P
Sbjct: 304 SKLTTFVNFPLRDLDLREFASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGE- 360
Query: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSP 1217
W F+DS+VT + SQV T AY+LFY + P
Sbjct: 361 ------WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPP 393
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 150 bits (379), Expect = 8e-36
Identities = 78/186 (41%), Positives = 111/186 (59%), Gaps = 3/186 (1%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G GL NLGNTCFMNS++Q LSNTRELRD+ R + ++++ + T L FA L+
Sbjct: 265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTA--LVEEFAKLI 322
Query: 555 RALWKGT-HHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYT 613
+ +W + + PS+ K + A +F GY Q DAQEF+ FLLDGLH ++NR+ +P +
Sbjct: 323 QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 382
Query: 614 ETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 673
+ D PD+ + W+++ R DS I DLF GQ KS L C C S FDPF L
Sbjct: 383 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 442
Query: 674 VPLPQK 679
+P+ ++
Sbjct: 443 LPIAKR 448
Score = 109 bits (272), Expect = 2e-23
Identities = 63/159 (39%), Positives = 87/159 (54%), Gaps = 10/159 (6%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL C+ LFT+ +VL +E C +C+ + K+ + R P +L++ LKRFS S I
Sbjct: 454 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS-ESRIRT 512
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
K+ V FP+R+LDL +F + Y+LYAV NH G +GGHYTA R P
Sbjct: 513 SKLTTFVNFPLRDLDLREFASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGE- 569
Query: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSP 1217
W F+DS+VT + SQV T AY+LFY + P
Sbjct: 570 ------WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPP 602
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 149 bits (376), Expect = 2e-35
Identities = 122/386 (31%), Positives = 170/386 (44%), Gaps = 58/386 (15%)
Query: 410 GGAPHPLTGQEEARAVEKDKSKARSEDTGLDSVA-TRTPMEHVTPK-------------- 454
GGA P A + S ARS + + V T + + H++ +
Sbjct: 36 GGAGGPGASGPAAPSSPSSPSSARSVGSFMSRVLKTLSTLSHLSSEGAAPDRGGLRSCFP 95
Query: 455 PETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQS 514
P A P C PP P SP E +PG GL N GNTCFMN+ +Q
Sbjct: 96 PGPAAAPTPPPC--PPPPASPAPPACAAEP--------VPGVAGLRNHGNTCFMNATLQC 145
Query: 515 LSNTRELRDFFHDRSFEA-----EINYNNPLGTG----GRLAIGFAVLLRALWKGTHHAF 565
LSNT ++ + A + P G G G + A L+RALW +
Sbjct: 146 LSNTELFAEYLALGQYRAGRPEPSPDPEQPAGRGAQGQGEVTEQLAHLVRALWTLEYTPQ 205
Query: 566 QPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQN-------KPYTETVDS 618
K IV+ A Q+ G +QHDAQEF+ +LLD +HEDLN KP +ET
Sbjct: 206 HSRDFKTIVSKNALQYRGNSQHDAQEFLLWLLDRVHEDLNHSVKQSGQPPLKPPSETDMM 265
Query: 619 DGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFL--YLPVPL 676
P V +F+ +LFQ QY+S L CP C K S TFDPFL LP+PL
Sbjct: 266 PEGPSFPVC-----------STFVQELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPIPL 314
Query: 677 PQKQKV-LPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIK 735
P + + + V Y + H I V +S T + + +++S + + + L E+
Sbjct: 315 PHTRPLYVTVVYQGKCSHCMRIGVAVPLS---GTVARLREAVSMETKIPTDQIVLTEMYY 371
Query: 736 NRFHRVFLPSHSLDTVSPSDTLLCFE 761
+ FHR F + L+TV SD + FE
Sbjct: 372 DGFHRSFCDTDDLETVHESDCIFAFE 397
Score = 129 bits (325), Expect = 1e-29
Identities = 95/276 (34%), Positives = 130/276 (47%), Gaps = 52/276 (18%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL QC L+T+ E LAP++AW CP CKQ ++ S L LW LP+VLI+ LKRF + R
Sbjct: 597 TLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGSITLSLWTLPDVLIIHLKRFR-QEGDRR 655
Query: 1119 DKINDLVEFPVRNLDLSKFCI--GQKEEQLPS-------------------YDLYAVINH 1157
K+ ++V+FP+ LD++ + Q LPS YDLYAV NH
Sbjct: 656 MKLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWRRPYGLGRDPEDYIYDLYAVCNH 715
Query: 1158 YGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRR--- 1214
+G M GGHYTA + D W FDDS V + E +V T+ AY+LFY+RR
Sbjct: 716 HGTMQGGHYTAYCK-------NSVDGLWYCFDDSDVQQLSEDEVCTQTAYILFYQRRTAI 768
Query: 1215 -----NSPVERPPRAGHSEHH----PDLGPAAEAAASQASRI-WQELEAEEEPVPEGSGP 1264
NS V + EH P PA+ +A+ + R L E E S
Sbjct: 769 PSWSANSSVAGSTSSSLCEHWVSRLPGSKPASVTSAASSRRTSLASLSESVEMTGERSED 828
Query: 1265 LGPWGPQDWVGPLPR----------GPTTPDEGCLR 1290
G + + +V + R P +E C+R
Sbjct: 829 DGGFSTRPFVRSVQRQSLSSRSSVTSPLAVNENCMR 864
>gi|148612811 ubiquitin specific protease 43 [Homo sapiens]
Length = 1123
Score = 126 bits (316), Expect = 2e-28
Identities = 89/273 (32%), Positives = 135/273 (49%), Gaps = 16/273 (5%)
Query: 494 PGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIG--FA 551
PG GL N GNTCFMN+V+Q LSNT L +F + A GR + A
Sbjct: 98 PGAQGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRA---------APGRAEVTEQLA 148
Query: 552 VLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKP 611
L+RALW + ++ K V+ SQF G +QHDA EF+ +LLD +HEDL P
Sbjct: 149 ALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQHDALEFLLWLLDRVHEDLEGSSRGP 208
Query: 612 YTETVDSDG-RPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFL 670
+E + + + E + Q SF+ FQ QY+S L CP C K S TFDPFL
Sbjct: 209 VSEKLPPEATKTSENCLSPSAQ--LPLGQSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFL 266
Query: 671 YLPVPLPQKQ-KVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLR 729
+ +P+P +Q + L V + ++ ++V ST + + +++ V + +
Sbjct: 267 CVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAV-PILSTVAALRKMVAEEGGVPADEVI 325
Query: 730 LAEVIKNRFHRVFLPSHSLDTVSPSDTLLCFEL 762
L E+ + F R F L+T++ D + F++
Sbjct: 326 LVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQV 358
Score = 122 bits (306), Expect = 2e-27
Identities = 75/220 (34%), Positives = 118/220 (53%), Gaps = 30/220 (13%)
Query: 1019 LALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEA 1078
LA+ W ++ + + F + + + A+ +A + TLD+C +T+ E LA ++A
Sbjct: 501 LAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQLAQDDA 560
Query: 1079 WYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLD----- 1133
W CP C+ ++ +L LW LP++LI+ LKRF + R+K++ LV+FP+ L+
Sbjct: 561 WKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFC-QVGERRNKLSTLVKFPLSGLNMAPHV 619
Query: 1134 ----------LSKFCIGQKEEQLPS-------YDLYAVINHYGGMIGGHYTACARLPNDR 1176
L + ++ + LP+ YDLYAV NH+G + GGHYTA R
Sbjct: 620 AQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCR----- 674
Query: 1177 SSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNS 1216
D W +DDSTV + E +V TR AY+LFY++RNS
Sbjct: 675 --NSLDGQWYSYDDSTVEPLREDEVNTRGAYILFYQKRNS 712
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 124 bits (312), Expect = 5e-28
Identities = 78/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G GL NLGNTCF+N+V+Q LS+TR LRDF R F E+ G L FA ++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 555 RALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNR------- 606
ALW + A P++ +A+ F+GY+Q DAQEF+ L++ LH ++NR
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 607 -IQNKPYTETVDSDGR-------PDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 658
+ N P G D+ A W+R+ R DS IVDLF GQ KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 659 CAKVSITFDPFLYLPVPLPQK 679
C S TF+ F L +P+P+K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407
Score = 104 bits (259), Expect = 6e-22
Identities = 62/169 (36%), Positives = 90/169 (53%), Gaps = 18/169 (10%)
Query: 1056 GHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFS-FRS 1114
G +L C NLFT+ E L E A C +C+Q ++K+L + R P +L++ L RFS R
Sbjct: 412 GKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRG 471
Query: 1115 FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN 1174
I + + V+FP++ L L F + P Y LYA+ NH G + GHYTA
Sbjct: 472 SIKKSSVG--VDFPLQRLSLGDF--ASDKAGSPVYQLYALCNHSGSVHYGHYTALC---- 523
Query: 1175 DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
R GW +++DS V+ V E+QV + YVLFY+ ++ PPR
Sbjct: 524 -----RCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQL----MQEPPR 563
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 124 bits (312), Expect = 5e-28
Identities = 78/201 (38%), Positives = 105/201 (52%), Gaps = 19/201 (9%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G GL NLGNTCF+N+V+Q LS+TR LRDF R F E+ G L FA ++
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGG---GRAQELTEAFADVI 266
Query: 555 RALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNR------- 606
ALW + A P++ +A+ F+GY+Q DAQEF+ L++ LH ++NR
Sbjct: 267 GALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPP 326
Query: 607 -IQNKPYTETVDSDGR-------PDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 658
+ N P G D+ A W+R+ R DS IVDLF GQ KS L C
Sbjct: 327 ILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQA 386
Query: 659 CAKVSITFDPFLYLPVPLPQK 679
C S TF+ F L +P+P+K
Sbjct: 387 CGYRSTTFEVFCDLSLPIPKK 407
Score = 104 bits (259), Expect = 6e-22
Identities = 62/169 (36%), Positives = 90/169 (53%), Gaps = 18/169 (10%)
Query: 1056 GHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFS-FRS 1114
G +L C NLFT+ E L E A C +C+Q ++K+L + R P +L++ L RFS R
Sbjct: 412 GKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRG 471
Query: 1115 FIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPN 1174
I + + V+FP++ L L F + P Y LYA+ NH G + GHYTA
Sbjct: 472 SIKKSSVG--VDFPLQRLSLGDF--ASDKAGSPVYQLYALCNHSGSVHYGHYTALC---- 523
Query: 1175 DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
R GW +++DS V+ V E+QV + YVLFY+ ++ PPR
Sbjct: 524 -----RCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQL----MQEPPR 563
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 101 bits (251), Expect = 5e-21
Identities = 65/171 (38%), Positives = 96/171 (56%), Gaps = 21/171 (12%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
+L CL FT E L E + C +CK+ ++++K+ + +LP VL + LKRF + +++ R
Sbjct: 363 SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYL-R 421
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPS---YDLYAVINHYGGMIG-GHYTACARLPN 1174
+K++ VEFP+R LD+ + + + E P YDL AV+ H+G +G GHYTA A
Sbjct: 422 NKVDTYVEFPLRGLDMKCYLL-EPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYA---- 476
Query: 1175 DRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPRAG 1225
+ W F+DSTVT DE VV AY+LFY VE +AG
Sbjct: 477 -----THEGRWFHFNDSTVTLTDEETVVKAKAYILFY------VEHQAKAG 516
Score = 87.8 bits (216), Expect = 6e-17
Identities = 61/201 (30%), Positives = 92/201 (45%), Gaps = 30/201 (14%)
Query: 497 TGLVNLGNTCFMNSVIQSLSNTRELRDFFHD--------------RSFEAEINYNNPLGT 542
TGL NLGNTCFMN+++QSLSN + +F + R++ +N +
Sbjct: 159 TGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVS- 217
Query: 543 GGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHE 602
L F L ALW+G+ AF P L +V F GY Q DA EFM +LLD LH
Sbjct: 218 ---LVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHL 274
Query: 603 DL----NRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPV 658
+L N + + + ++ A + + +F G ++++ C +
Sbjct: 275 ELQGGFNGVSRSAILQENSTLSASNKCCINGA--------STVVTAIFGGILQNEVNCLI 326
Query: 659 CAKVSITFDPFLYLPVPLPQK 679
C S FDPFL L + +P +
Sbjct: 327 CGTESRKFDPFLDLSLDIPSQ 347
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 95.9 bits (237), Expect = 2e-19
Identities = 59/163 (36%), Positives = 81/163 (49%), Gaps = 10/163 (6%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL+ CL F + L + + C +CK+ R K + RLP +L + LKRF ++
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFR-HEVMYS 596
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTA-CARLPNDRS 1177
KIN V FP+ LDL F + Q+ +YDL +VI H+G GHY A C + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQ- 655
Query: 1178 SQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVER 1220
W FDD VT V E+ V YVLFYR+ + R
Sbjct: 656 -------WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMR 691
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/164 (31%), Positives = 78/164 (47%), Gaps = 16/164 (9%)
Query: 461 SPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRE 520
SP P+ P+ P++ E E E+ + G TG+ NLGN+C+MN+ +Q+LSN
Sbjct: 112 SPPPS---HPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPP 168
Query: 521 LRDFFHDRSFEAEINYNNPLGTGGRLAI--GFAVLLRALWKGTHHAF-QPSKLKAIVASK 577
L FF + + T + A+ + L+ +W ++ P+ L +
Sbjct: 169 LTQFF--------LECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLV 220
Query: 578 ASQFTGYAQHDAQEFMAFLLDGLHEDLNR--IQNKPYTETVDSD 619
F GYAQ D QEF+ L+D LHE+L + TE DSD
Sbjct: 221 NPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSD 264
Score = 37.7 bits (86), Expect = 0.073
Identities = 19/57 (33%), Positives = 32/57 (56%)
Query: 624 EVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
+V++ + +R + R S I D+F G S + C C +VS T + F L +P+P K+
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 483
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 95.9 bits (237), Expect = 2e-19
Identities = 59/163 (36%), Positives = 81/163 (49%), Gaps = 10/163 (6%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL+ CL F + L + + C +CK+ R K + RLP +L + LKRF ++
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFR-HEVMYS 596
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTA-CARLPNDRS 1177
KIN V FP+ LDL F + Q+ +YDL +VI H+G GHY A C + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQ- 655
Query: 1178 SQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVER 1220
W FDD VT V E+ V YVLFYR+ + R
Sbjct: 656 -------WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMR 691
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/164 (31%), Positives = 78/164 (47%), Gaps = 16/164 (9%)
Query: 461 SPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRE 520
SP P+ P+ P++ E E E+ + G TG+ NLGN+C+MN+ +Q+LSN
Sbjct: 112 SPPPS---HPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPP 168
Query: 521 LRDFFHDRSFEAEINYNNPLGTGGRLAI--GFAVLLRALWKGTHHAF-QPSKLKAIVASK 577
L FF + + T + A+ + L+ +W ++ P+ L +
Sbjct: 169 LTQFF--------LECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLV 220
Query: 578 ASQFTGYAQHDAQEFMAFLLDGLHEDLNR--IQNKPYTETVDSD 619
F GYAQ D QEF+ L+D LHE+L + TE DSD
Sbjct: 221 NPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSD 264
Score = 37.7 bits (86), Expect = 0.073
Identities = 19/57 (33%), Positives = 32/57 (56%)
Query: 624 EVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
+V++ + +R + R S I D+F G S + C C +VS T + F L +P+P K+
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 483
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 95.9 bits (237), Expect = 2e-19
Identities = 59/163 (36%), Positives = 81/163 (49%), Gaps = 10/163 (6%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL+ CL F + L + + C +CK+ R K + RLP +L + LKRF ++
Sbjct: 538 TLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFR-HEVMYS 596
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTA-CARLPNDRS 1177
KIN V FP+ LDL F + Q+ +YDL +VI H+G GHY A C + N +
Sbjct: 597 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQ- 655
Query: 1178 SQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVER 1220
W FDD VT V E+ V YVLFYR+ + R
Sbjct: 656 -------WYEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMR 691
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/164 (31%), Positives = 78/164 (47%), Gaps = 16/164 (9%)
Query: 461 SPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRE 520
SP P+ P+ P++ E E E+ + G TG+ NLGN+C+MN+ +Q+LSN
Sbjct: 112 SPPPS---HPLKAVPIAVADEGESESEDDDLKPRGLTGMKNLGNSCYMNAALQALSNCPP 168
Query: 521 LRDFFHDRSFEAEINYNNPLGTGGRLAI--GFAVLLRALWKGTHHAF-QPSKLKAIVASK 577
L FF + + T + A+ + L+ +W ++ P+ L +
Sbjct: 169 LTQFF--------LECGGLVRTDKKPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLV 220
Query: 578 ASQFTGYAQHDAQEFMAFLLDGLHEDLNR--IQNKPYTETVDSD 619
F GYAQ D QEF+ L+D LHE+L + TE DSD
Sbjct: 221 NPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSD 264
Score = 37.7 bits (86), Expect = 0.073
Identities = 19/57 (33%), Positives = 32/57 (56%)
Query: 624 EVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
+V++ + +R + R S I D+F G S + C C +VS T + F L +P+P K+
Sbjct: 427 QVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKE 483
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 94.7 bits (234), Expect = 5e-19
Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL CL F + L + + C +CK+ R K + P +L + LKRF ++
Sbjct: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-HELMFS 618
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
KI+ V FP+ LDL F Q+ +YDL +VI H+G GHY A R N+ ++
Sbjct: 619 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR--NNLNN 676
Query: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
W FDD +VT V ES V AYVLFYR+ + ++ R
Sbjct: 677 L-----WYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERR 716
Score = 78.6 bits (192), Expect = 4e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 479 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 538
D ++ E +EE ++ G TGL N+GNTC+MN+ +Q+LSN L FF D A +
Sbjct: 167 DDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKK- 225
Query: 539 PLGTGGRLAIGFAVLLRALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 597
+ + L+ LW K + P+ L + + F GY+Q DAQEF+ L+
Sbjct: 226 -----PAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
Query: 598 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRND 639
D LHE+L + ++ + P + EE + K ++D
Sbjct: 281 DLLHEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
Score = 36.2 bits (82), Expect = 0.21
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 632 QRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
++HK + S I D+F G S + C C +VS+T + F L +P+P K+
Sbjct: 466 KQHK-KYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKE 513
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 94.7 bits (234), Expect = 5e-19
Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL CL F + L + + C +CK+ R K + P +L + LKRF ++
Sbjct: 568 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-HELMFS 626
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
KI+ V FP+ LDL F Q+ +YDL +VI H+G GHY A R N+ ++
Sbjct: 627 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR--NNLNN 684
Query: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
W FDD +VT V ES V AYVLFYR+ + ++ R
Sbjct: 685 L-----WYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERR 724
Score = 78.6 bits (192), Expect = 4e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 479 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 538
D ++ E +EE ++ G TGL N+GNTC+MN+ +Q+LSN L FF D A +
Sbjct: 167 DDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKK- 225
Query: 539 PLGTGGRLAIGFAVLLRALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 597
+ + L+ LW K + P+ L + + F GY+Q DAQEF+ L+
Sbjct: 226 -----PAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 280
Query: 598 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRND 639
D LHE+L + ++ + P + EE + K ++D
Sbjct: 281 DLLHEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 315
Score = 36.2 bits (82), Expect = 0.21
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 632 QRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
++HK + S I D+F G S + C C +VS+T + F L +P+P K+
Sbjct: 466 KQHK-KYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKE 513
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 94.7 bits (234), Expect = 5e-19
Identities = 58/165 (35%), Positives = 82/165 (49%), Gaps = 8/165 (4%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
TL CL F + L + + C +CK+ R K + P +L + LKRF ++
Sbjct: 537 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFR-HELMFS 595
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
KI+ V FP+ LDL F Q+ +YDL +VI H+G GHY A R N+ ++
Sbjct: 596 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCR--NNLNN 653
Query: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSPVERPPR 1223
W FDD +VT V ES V AYVLFYR+ + ++ R
Sbjct: 654 L-----WYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERR 693
Score = 78.6 bits (192), Expect = 4e-14
Identities = 50/162 (30%), Positives = 80/162 (49%), Gaps = 14/162 (8%)
Query: 479 DSVEEEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNN 538
D ++ E +EE ++ G TGL N+GNTC+MN+ +Q+LSN L FF D A +
Sbjct: 136 DDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKK- 194
Query: 539 PLGTGGRLAIGFAVLLRALW-KGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 597
+ + L+ LW K + P+ L + + F GY+Q DAQEF+ L+
Sbjct: 195 -----PAICKSYLKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLM 249
Query: 598 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRND 639
D LHE+L + ++ + P + EE + K ++D
Sbjct: 250 DLLHEELKE-------QVMEVEEDPQTITTEETMEEDKSQSD 284
Score = 36.2 bits (82), Expect = 0.21
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 632 QRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
++HK + S I D+F G S + C C +VS+T + F L +P+P K+
Sbjct: 435 KQHK-KYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKE 482
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 90.9 bits (224), Expect = 7e-18
Identities = 59/179 (32%), Positives = 85/179 (47%), Gaps = 24/179 (13%)
Query: 1050 GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKR 1109
GE+ +G TL CL FTRPE L C C ++E++KQL + +LP V LKR
Sbjct: 352 GESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKR 411
Query: 1110 FSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQL--------------PSYDLYAVI 1155
F + + R KI V FP+ LD++ F KE ++ Y L+AV+
Sbjct: 412 FEHSAKL-RRKITTYVSFPL-ELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVV 469
Query: 1156 NHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRR 1214
NH G + GHYT+ R D+ W DD+ +T V+ Y+LFY ++
Sbjct: 470 NHQGTLESGHYTSFIRQHKDQ--------WFKCDDAIITKASIKDVLDSEGYLLFYHKQ 520
Score = 85.5 bits (210), Expect = 3e-16
Identities = 59/187 (31%), Positives = 84/187 (44%), Gaps = 26/187 (13%)
Query: 492 CLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFA 551
C G GL+NLGNTCFMN ++Q+L++T LRDFF E+ L +
Sbjct: 171 CTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQ-----SPSSCLVCEMS 225
Query: 552 VLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKP 611
L + + G P KL +V + A GY Q DA EF+ LD LH
Sbjct: 226 SLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKG----- 280
Query: 612 YTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVD-LFQGQYKSKLVCPVCAKVSITFDPFL 670
D +G+ + + + + I+D +F G +S + C VC VS T DPF
Sbjct: 281 -----DDNGK----------KANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFW 325
Query: 671 YLPVPLP 677
+ + LP
Sbjct: 326 DISLDLP 332
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 90.1 bits (222), Expect = 1e-17
Identities = 61/179 (34%), Positives = 85/179 (47%), Gaps = 24/179 (13%)
Query: 1050 GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKR 1109
GE+ G TL CL FTRPE L C C+ ++E++KQL + +LP V KR
Sbjct: 253 GESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKR 312
Query: 1110 FSFRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEE------QLPS--------YDLYAVI 1155
F S R KI + FP+ LD++ F KE QLP+ Y L+AV+
Sbjct: 313 FE-HSAKQRRKITTYISFPL-ELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVV 370
Query: 1156 NHYGGMIGGHYTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRR 1214
NH G + GHYT+ R D+ W DD+ +T V+ Y+LFY ++
Sbjct: 371 NHQGTLESGHYTSFIRHHKDQ--------WFKCDDAVITKASIKDVLDSEGYLLFYHKQ 421
Score = 79.7 bits (195), Expect = 2e-14
Identities = 59/189 (31%), Positives = 81/189 (42%), Gaps = 36/189 (19%)
Query: 495 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL 554
G GL+NLGNTCFMN ++Q+L++T LRDFF E+ L + L
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELC-----LVCEMSSLF 130
Query: 555 RALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLH-----EDLNRIQN 609
R L+ G P KL +V A GY Q DA EF+ LD LH +D+ + N
Sbjct: 131 RELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAAN 190
Query: 610 KPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVD-LFQGQYKSKLVCPVCAKVSITFDP 668
P + + I+D +F G +S + C C VS T DP
Sbjct: 191 NP-------------------------NHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDP 225
Query: 669 FLYLPVPLP 677
+ + LP
Sbjct: 226 CWDISLDLP 234
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 88.6 bits (218), Expect = 4e-17
Identities = 70/254 (27%), Positives = 112/254 (44%), Gaps = 32/254 (12%)
Query: 452 TPKPETHLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKK-----------VCLPGFTGLV 500
TPKPE + + + + + +S E+E E+K+ C GL
Sbjct: 146 TPKPEKDNGNIE-------LENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLS 198
Query: 501 NLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNP------------LGTGGRLAI 548
NLGNTCF N+V+Q+LS T LR+ + I P L G L +
Sbjct: 199 NLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTL 258
Query: 549 GFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLH-EDLNRI 607
+ L + + P +L + V KA +F GY Q D+QE + +LLDG+ E+ R+
Sbjct: 259 AMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRV 318
Query: 608 QNKPYTETVDSDGRPDEVVAEEAWQRHKMRN-DSFIVDLFQGQYKSKLVCPVCAKVSITF 666
+S + DE + + K ++ SF+ +F G+ S ++C C VS+
Sbjct: 319 SKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVH 378
Query: 667 DPFLYLPVPLPQKQ 680
+ FL L +P+ Q
Sbjct: 379 ESFLDLSLPVLDDQ 392
Score = 70.9 bits (172), Expect = 8e-12
Identities = 64/214 (29%), Positives = 86/214 (40%), Gaps = 47/214 (21%)
Query: 1044 EDPGSA------GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHR--------- 1088
EDP +A E ++ CL FTR E L C C + +
Sbjct: 610 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIK 669
Query: 1089 --------EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140
A KQ+L+ P VL + LKRF F R K+N ++FP LDL+ FC
Sbjct: 670 GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFP-EILDLAPFCTL 727
Query: 1141 Q-----KEEQLPSYDLYAVINHYGGMIGGHYTACAR----------------LPNDRSSQ 1179
+ +E Y LY V+ H G M GHYTA A+ +P D
Sbjct: 728 KCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQD-FEM 786
Query: 1180 RSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1213
S W D+ V V ++V+ AY+LFY R
Sbjct: 787 ESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 820
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/227 (28%), Positives = 102/227 (44%), Gaps = 25/227 (11%)
Query: 479 DSVEEEEEEEKK-----------VCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHD 527
+S E+E E+K+ C GL NLGNTCF N+V+Q+LS T LR+ +
Sbjct: 167 ESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKE 226
Query: 528 RSFEAEINYNNP------------LGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVA 575
I P L G L + + L + + P +L + V
Sbjct: 227 VKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVC 286
Query: 576 SKASQFTGYAQHDAQEFMAFLLDGLH-EDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRH 634
KA +F GY Q D+QE + +LLDG+ E+ R+ +S + DE + +
Sbjct: 287 KKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYE 346
Query: 635 KMRN-DSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
K ++ SF+ +F G+ S ++C C VS+ + FL L +P+ Q
Sbjct: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQ 393
Score = 70.9 bits (172), Expect = 8e-12
Identities = 64/214 (29%), Positives = 86/214 (40%), Gaps = 47/214 (21%)
Query: 1044 EDPGSA------GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHR--------- 1088
EDP +A E ++ CL FTR E L C C + +
Sbjct: 611 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIK 670
Query: 1089 --------EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140
A KQ+L+ P VL + LKRF F R K+N ++FP LDL+ FC
Sbjct: 671 GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFP-EILDLAPFCTL 728
Query: 1141 Q-----KEEQLPSYDLYAVINHYGGMIGGHYTACAR----------------LPNDRSSQ 1179
+ +E Y LY V+ H G M GHYTA A+ +P D
Sbjct: 729 KCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQD-FEM 787
Query: 1180 RSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1213
S W D+ V V ++V+ AY+LFY R
Sbjct: 788 ESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/227 (28%), Positives = 102/227 (44%), Gaps = 25/227 (11%)
Query: 479 DSVEEEEEEEKK-----------VCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHD 527
+S E+E E+K+ C GL NLGNTCF N+V+Q+LS T LR+ +
Sbjct: 167 ESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKE 226
Query: 528 RSFEAEINYNNP------------LGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVA 575
I P L G L + + L + + P +L + V
Sbjct: 227 VKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVC 286
Query: 576 SKASQFTGYAQHDAQEFMAFLLDGLH-EDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRH 634
KA +F GY Q D+QE + +LLDG+ E+ R+ +S + DE + +
Sbjct: 287 KKAVRFKGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYE 346
Query: 635 KMRN-DSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQKQ 680
K ++ SF+ +F G+ S ++C C VS+ + FL L +P+ Q
Sbjct: 347 KKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQ 393
Score = 70.9 bits (172), Expect = 8e-12
Identities = 64/214 (29%), Positives = 86/214 (40%), Gaps = 47/214 (21%)
Query: 1044 EDPGSA------GEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHR--------- 1088
EDP +A E ++ CL FTR E L C C + +
Sbjct: 611 EDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIK 670
Query: 1089 --------EASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFCIG 1140
A KQ+L+ P VL + LKRF F R K+N ++FP LDL+ FC
Sbjct: 671 GERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLR-KVNKHIKFP-EILDLAPFCTL 728
Query: 1141 Q-----KEEQLPSYDLYAVINHYGGMIGGHYTACAR----------------LPNDRSSQ 1179
+ +E Y LY V+ H G M GHYTA A+ +P D
Sbjct: 729 KCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGDIPQD-FEM 787
Query: 1180 RSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1213
S W D+ V V ++V+ AY+LFY R
Sbjct: 788 ESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYER 821
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 86.7 bits (213), Expect = 1e-16
Identities = 55/169 (32%), Positives = 81/169 (47%), Gaps = 23/169 (13%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
+L CL FTRPE L C C+ ++E++KQL + +LP V LKRF R
Sbjct: 548 SLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVG-KQR 606
Query: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLP-------------SYDLYAVINHYGGMIGGH 1165
KIN + FP+ LD++ F KE ++ Y L+AVINH+G + GH
Sbjct: 607 RKINTFISFPL-ELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGH 665
Query: 1166 YTACARLPNDRSSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRR 1214
YT+ R D+ W DD+ +T ++ Y+LFY ++
Sbjct: 666 YTSFIRQQKDQ--------WFSCDDAIITKATIEDLLYSEGYLLFYHKQ 706
Score = 77.8 bits (190), Expect = 6e-14
Identities = 55/195 (28%), Positives = 86/195 (44%), Gaps = 24/195 (12%)
Query: 483 EEEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGT 542
+++ +K V G GL+NLGNTCFMN ++Q+L++ L+DFF + + +
Sbjct: 349 KKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLC-- 406
Query: 543 GGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHE 602
L + L A++ G+ P KL ++ A GY Q DA EF+ +LD LH
Sbjct: 407 ---LVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHR 463
Query: 603 DLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKV 662
D+ +EA + + I +F G +S + C C V
Sbjct: 464 H-----------------SKDDSGGQEA--NNPNCCNCIIDQIFTGGLQSDVTCQACHSV 504
Query: 663 SITFDPFLYLPVPLP 677
S T DP + + LP
Sbjct: 505 STTIDPCWDISLDLP 519
>gi|122937412 ubiquitin specific peptidase 45 [Homo sapiens]
Length = 814
Score = 81.3 bits (199), Expect = 6e-15
Identities = 60/210 (28%), Positives = 102/210 (48%), Gaps = 25/210 (11%)
Query: 498 GLVNLGNTCFMNSVIQSLSNTRELRDFFHD--------RSFEAEINYNNP----LGTGGR 545
G+ NLGNTCF N+V+Q+L+ T L D ++ + F + + +P L G
Sbjct: 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDSQLDPLVVELSRPGP 250
Query: 546 LAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLH-EDL 604
L + L ++ + P L + KA +F + Q D+QE + +LLD + E+
Sbjct: 251 LTSALFLFLHSMKETEKGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEET 310
Query: 605 NRIQ-------NKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCP 657
RIQ N P T+T D + R + V + KM +FI +F G+ S ++C
Sbjct: 311 KRIQASILKAFNNPTTKTADDETR--KKVKAYGKEGVKM---NFIDRIFIGELTSTVMCE 365
Query: 658 VCAKVSITFDPFLYLPVPLPQKQKVLPVFY 687
CA +S DPF+ + +P+ +++ P+ +
Sbjct: 366 ECANISTVKDPFIDISLPIIEERVSKPLLW 395
Score = 71.2 bits (173), Expect = 6e-12
Identities = 58/200 (29%), Positives = 86/200 (43%), Gaps = 51/200 (25%)
Query: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHRE-------------------ASKQLLLWRL 1099
++ CL FT E+L C C ++++ A KQLL+ +
Sbjct: 619 SIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEKKVEGVYTNARKQLLISAV 678
Query: 1100 PNVLIVQLKRFSFRSFIWRDKINDLVEFPVRNLDLSKFC--------IGQKEEQLPSYDL 1151
P VLI+ LKRF R K+N V+FP+ LDL+ FC +G K Y L
Sbjct: 679 PAVLILHLKRFHQAGLSLR-KVNRHVDFPLM-LDLAPFCSATCKNASVGDKV----LYGL 732
Query: 1152 YAVINHYGGMIGGHYTACAR-----------------LPNDRSSQRSDVG-WRLFDDSTV 1193
Y ++ H G M GHYTA + +P +++ G W D+ +
Sbjct: 733 YGIVEHSGSMREGHYTAYVKVRTPSRKLSEHNTKKKNVPGLKAADNESAGQWVHVSDTYL 792
Query: 1194 TTVDESQVVTRYAYVLFYRR 1213
V ES+ ++ AY+LFY R
Sbjct: 793 QVVPESRALSAQAYLLFYER 812
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,303,695
Number of Sequences: 37866
Number of extensions: 3151213
Number of successful extensions: 14444
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 13476
Number of HSP's gapped (non-prelim): 901
length of query: 1318
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1204
effective length of database: 13,930,794
effective search space: 16772675976
effective search space used: 16772675976
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.