BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|5730045 solute carrier family 16, member 2 [Homo sapiens] (613 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|5730045 solute carrier family 16, member 2 [Homo sapiens] 1247 0.0 gi|18699730 solute carrier family 16, member 10 [Homo sapiens] 515 e-146 gi|109288010 solute carrier family 16, member 3 [Homo sapiens] 177 3e-44 gi|109288012 solute carrier family 16, member 3 [Homo sapiens] 177 3e-44 gi|4759112 solute carrier family 16, member 3 [Homo sapiens] 177 3e-44 gi|24431958 solute carrier family 16, member 7 [Homo sapiens] 167 2e-41 gi|115583685 solute carrier family 16, member 1 [Homo sapiens] 164 2e-40 gi|114796626 solute carrier family 16, member 8 [Homo sapiens] 163 4e-40 gi|42475555 monocarboxylate transporter 13 [Homo sapiens] 162 8e-40 gi|23503293 solute carrier family 16, member 11 [Homo sapiens] 154 3e-37 gi|157041233 solute carrier family 16 (monocarboxylic acid trans... 150 3e-36 gi|4759116 solute carrier family 16, member 5 [Homo sapiens] 144 2e-34 gi|41327156 solute carrier family 16 (monocarboxylic acid transp... 141 2e-33 gi|169217968 PREDICTED: similar to solute carrier family 16, mem... 124 3e-28 gi|34916028 solute carrier family 16 (monocarboxylic acid transp... 101 2e-21 gi|40789261 solute carrier family 16, member 6 [Homo sapiens] 94 5e-19 gi|4759114 solute carrier family 16, member 4 [Homo sapiens] 85 2e-16 gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 71 3e-12 gi|4505419 nucleolar protein 3 [Homo sapiens] 62 2e-09 gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 60 8e-09 gi|83977459 pleckstrin homology-like domain, family A, member 1 ... 57 5e-08 gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 55 2e-07 gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 55 2e-07 gi|55741677 SET domain containing 1A [Homo sapiens] 54 3e-07 gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 54 3e-07 gi|108796058 ral guanine nucleotide dissociation stimulator isof... 54 3e-07 gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 52 1e-06 gi|156523246 proline-rich transmembrane protein 2 [Homo sapiens] 52 1e-06 gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 52 2e-06 gi|47132519 Ras association and pleckstrin homology domains 1 is... 52 2e-06 >gi|5730045 solute carrier family 16, member 2 [Homo sapiens] Length = 613 Score = 1247 bits (3226), Expect = 0.0 Identities = 613/613 (100%), Positives = 613/613 (100%) Query: 1 MGRGGGGLDVGGGGEGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQ 60 MGRGGGGLDVGGGGEGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQ Sbjct: 1 MGRGGGGLDVGGGGEGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQ 60 Query: 61 SGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPV 120 SGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPV Sbjct: 61 SGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPV 120 Query: 121 PPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFA 180 PPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFA Sbjct: 121 PPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFA 180 Query: 181 ATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTD 240 ATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTD Sbjct: 181 ATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTD 240 Query: 241 RLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQR 300 RLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQR Sbjct: 241 RLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQR 300 Query: 301 RLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS 360 RLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS Sbjct: 301 RLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPS 360 Query: 361 SQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYV 420 SQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYV Sbjct: 361 SQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYV 420 Query: 421 EEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPL 480 EEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPL Sbjct: 421 EEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPL 480 Query: 481 CRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIA 540 CRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIA Sbjct: 481 CRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIA 540 Query: 541 GLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNG 600 GLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNG Sbjct: 541 GLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNG 600 Query: 601 ELLPGSPNPEEPI 613 ELLPGSPNPEEPI Sbjct: 601 ELLPGSPNPEEPI 613 >gi|18699730 solute carrier family 16, member 10 [Homo sapiens] Length = 515 Score = 515 bits (1326), Expect = e-146 Identities = 266/499 (53%), Positives = 336/499 (67%), Gaps = 18/499 (3%) Query: 97 QEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPA-PLPELEFESERVHEPEPTP 155 QE S SE +P P P PP P P P P+ A E+E EP P Sbjct: 5 QEEPDSARGTSEAQPLG-PAPTGAAPP-PGPGPSDSPEAAVEKVEVELAGPATAEPHEPP 62 Query: 156 TVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEE--EKEKNRQV 213 +PPEGG+GW+V+ AA WCNGS+FGI N+ G+L+ +LE K+ ++ V Sbjct: 63 -----------EPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMV 111 Query: 214 EFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYF 273 F+ AWVG+L+MGMIFFC PIVS+FTD GCR TA GAAV F+GL +SSF SS+ Y Sbjct: 112 -FKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYL 170 Query: 274 TYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKL 333 TYGI+F CGCSFA+QPSLVILGHYF++RLGL NG+V+AGSS+F++ P L+R+L D + L Sbjct: 171 TYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGL 230 Query: 334 AQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRF-LAQLRKYFNMRVFRQ 392 T +VL FMFVL L TYRPL S++D S +L R + +K FN +F+ Sbjct: 231 FYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKV 290 Query: 393 RTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHIS 452 Y +WA GI A GYFVPYVHLMK+V E F + K V+L+CIG TSG+GRL+ G I+ Sbjct: 291 TAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIA 350 Query: 453 DSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFEL 512 D +PG+KK+YLQVLSF +GLMSMMIPLC FG LI VCL +GL DG FI+IMAPIAFEL Sbjct: 351 DYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFEL 410 Query: 513 VGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 572 VG SQAIG+LLG M++PM GPPIAGLLR+ G Y VAFY AGVPP+IG +L F+P Sbjct: 411 VGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIP 470 Query: 573 LMHQRMFKKEQRDSSKDKM 591 +H + ++ + + K+KM Sbjct: 471 WIHSKKQREISKTTGKEKM 489 >gi|109288010 solute carrier family 16, member 3 [Homo sapiens] Length = 465 Score = 177 bits (449), Expect = 3e-44 Identities = 126/465 (27%), Positives = 209/465 (44%), Gaps = 44/465 (9%) Query: 165 GFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALA 224 G + P+GG+GW V+F G + +V + + L++E AW+ ++ Sbjct: 12 GVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT----AWISSIL 67 Query: 225 MGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCS 284 + M++ P+ S+ +R GCR G A +G+ +SF S+ Y T G++ G G + Sbjct: 68 LAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLA 127 Query: 285 FAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFM 344 FQPSL++L YF +R +ANG+ +AGS +F + L ++L D+ F +L + Sbjct: 128 LNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLL 187 Query: 345 FVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAA 404 + + RPL+ ++Q P R R+ ++ VFR R + ++A + Sbjct: 188 LNCCVCAALMRPLVVTAQ--PGSGPPR--------PSRRLLDLSVFRDRGFVLYAVAASV 237 Query: 405 AALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKK---- 460 LG FVP V ++ Y ++ + LL +G R +G ++ GL K Sbjct: 238 MVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVA----GLGKVRPY 293 Query: 461 -IYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 519 +YL S GL + D+GGL+V C+F G+ G + + +VG + S Sbjct: 294 SVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFS 353 Query: 520 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL----FF----- 570 AIG +L M A+ ++ GPP G L + Y F AG + ++IL FF Sbjct: 354 SAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKK 413 Query: 571 -------VPLMHQRMFKKEQRDSSKD-----KMLAPDPDPNGELL 603 V + K DS D L +P+ NGE++ Sbjct: 414 PKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVV 458 >gi|109288012 solute carrier family 16, member 3 [Homo sapiens] Length = 465 Score = 177 bits (449), Expect = 3e-44 Identities = 126/465 (27%), Positives = 209/465 (44%), Gaps = 44/465 (9%) Query: 165 GFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALA 224 G + P+GG+GW V+F G + +V + + L++E AW+ ++ Sbjct: 12 GVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT----AWISSIL 67 Query: 225 MGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCS 284 + M++ P+ S+ +R GCR G A +G+ +SF S+ Y T G++ G G + Sbjct: 68 LAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLA 127 Query: 285 FAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFM 344 FQPSL++L YF +R +ANG+ +AGS +F + L ++L D+ F +L + Sbjct: 128 LNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLL 187 Query: 345 FVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAA 404 + + RPL+ ++Q P R R+ ++ VFR R + ++A + Sbjct: 188 LNCCVCAALMRPLVVTAQ--PGSGPPR--------PSRRLLDLSVFRDRGFVLYAVAASV 237 Query: 405 AALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKK---- 460 LG FVP V ++ Y ++ + LL +G R +G ++ GL K Sbjct: 238 MVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVA----GLGKVRPY 293 Query: 461 -IYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 519 +YL S GL + D+GGL+V C+F G+ G + + +VG + S Sbjct: 294 SVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFS 353 Query: 520 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL----FF----- 570 AIG +L M A+ ++ GPP G L + Y F AG + ++IL FF Sbjct: 354 SAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKK 413 Query: 571 -------VPLMHQRMFKKEQRDSSKD-----KMLAPDPDPNGELL 603 V + K DS D L +P+ NGE++ Sbjct: 414 PKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVV 458 >gi|4759112 solute carrier family 16, member 3 [Homo sapiens] Length = 465 Score = 177 bits (449), Expect = 3e-44 Identities = 126/465 (27%), Positives = 209/465 (44%), Gaps = 44/465 (9%) Query: 165 GFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALA 224 G + P+GG+GW V+F G + +V + + L++E AW+ ++ Sbjct: 12 GVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT----AWISSIL 67 Query: 225 MGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCS 284 + M++ P+ S+ +R GCR G A +G+ +SF S+ Y T G++ G G + Sbjct: 68 LAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLA 127 Query: 285 FAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFM 344 FQPSL++L YF +R +ANG+ +AGS +F + L ++L D+ F +L + Sbjct: 128 LNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLL 187 Query: 345 FVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAA 404 + + RPL+ ++Q P R R+ ++ VFR R + ++A + Sbjct: 188 LNCCVCAALMRPLVVTAQ--PGSGPPR--------PSRRLLDLSVFRDRGFVLYAVAASV 237 Query: 405 AALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKK---- 460 LG FVP V ++ Y ++ + LL +G R +G ++ GL K Sbjct: 238 MVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVA----GLGKVRPY 293 Query: 461 -IYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 519 +YL S GL + D+GGL+V C+F G+ G + + +VG + S Sbjct: 294 SVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFS 353 Query: 520 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL----FF----- 570 AIG +L M A+ ++ GPP G L + Y F AG + ++IL FF Sbjct: 354 SAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKK 413 Query: 571 -------VPLMHQRMFKKEQRDSSKD-----KMLAPDPDPNGELL 603 V + K DS D L +P+ NGE++ Sbjct: 414 PKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVV 458 >gi|24431958 solute carrier family 16, member 7 [Homo sapiens] Length = 478 Score = 167 bits (424), Expect = 2e-41 Identities = 108/433 (24%), Positives = 208/433 (48%), Gaps = 18/433 (4%) Query: 168 PPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGM 227 PP+GG+GW+VV AA G + +V + + +E ++ + AW+ ++ + + Sbjct: 13 PPDGGWGWIVVGAAFISIGFSYAFPKAVTVFF----KEIQQIFHTTYSEIAWISSIMLAV 68 Query: 228 IFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAF 287 ++ P+ S+ ++ G R AG + +G+ +SF+SS+ Y T G + G G +F Sbjct: 69 MYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNL 128 Query: 288 QPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVL 347 QP+L I+G YF R+ +ANG+ AGS +F S + L + +F +L + + Sbjct: 129 QPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNA 188 Query: 348 MLLSLTYRPLLPS------------SQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTY 395 + RPL P+ ++D S + ++T + ++ KY + +F+ R + Sbjct: 189 CVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTW-EKVNKYLDFSLFKHRGF 247 Query: 396 RIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSI 455 I+ G LG+F P + L Y +++ + LL + R G I++S Sbjct: 248 LIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSK 307 Query: 456 PGLKKI-YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVG 514 +I Y + + G+ ++ PL +D+ L++ +F GL G +++ +LVG Sbjct: 308 YIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVG 367 Query: 515 PMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLM 574 + S A+G + + P++ GPP+AG L + G+Y + G + +V L + Sbjct: 368 APRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAI 427 Query: 575 HQRMFKKEQRDSS 587 + R+ KE+++ + Sbjct: 428 NYRLLAKERKEEN 440 >gi|115583685 solute carrier family 16, member 1 [Homo sapiens] Length = 500 Score = 164 bits (415), Expect = 2e-40 Identities = 110/454 (24%), Positives = 205/454 (45%), Gaps = 32/454 (7%) Query: 165 GFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALA 224 G+ PP+GG+GW VV A G + S+ + + +E + + +W+ ++ Sbjct: 10 GYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFF----KEIEGIFHATTSEVSWISSIM 65 Query: 225 MGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCS 284 + +++ PI SI ++ G RI G ++ GL +SF +++ Y G++ G G + Sbjct: 66 LAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLA 125 Query: 285 FAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFM 344 F P+L ++G YF +R LANG+ AGS +F + L ++ +F +L + Sbjct: 126 FNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLL 185 Query: 345 FVLMLLSLTYRPLLP-----------SSQDTPSKRGVRT-LH---------------QRF 377 + RP+ P +S + K GV+ LH + Sbjct: 186 LNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSV 245 Query: 378 LAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCI 437 + ++ ++ +F R + ++ G G F P V L Y + + +++ LL + Sbjct: 246 FQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSIL 305 Query: 438 GATSGLGRLVSGHISDSIPGLKKI-YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGL 496 + R G ++++ P +I Y S + G+ M+ PL + G V F G Sbjct: 306 AFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGF 365 Query: 497 CDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYF 556 G+ +++ +LVGP + S A+G + + P++ GPP+ G L + +GDY ++ Sbjct: 366 AFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWA 425 Query: 557 AGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDK 590 GV II + LF ++ R+ KEQ+ + + K Sbjct: 426 CGVVLIISGIYLFIGMGINYRLLAKEQKANEQKK 459 >gi|114796626 solute carrier family 16, member 8 [Homo sapiens] Length = 504 Score = 163 bits (413), Expect = 4e-40 Identities = 119/432 (27%), Positives = 190/432 (43%), Gaps = 33/432 (7%) Query: 161 GTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWV 220 G RG PP+GG+GWVV+ A G +G +V + + L+ + AWV Sbjct: 5 GPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDT----AWV 60 Query: 221 GALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFG 280 ++ + M++ P+ SI R GCR AG +A G+ +SF + L Y T G+L G Sbjct: 61 SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG 120 Query: 281 CGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVL 340 G + FQPSL++LG YF+RR LANG+ +AGS +F + L + L ++ F +L Sbjct: 121 LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL 180 Query: 341 STFMFVLMLLSLTYRP-----LLPSSQDTPSKRG--------------VRTLHQRFLAQL 381 + RP P + G +R R + Sbjct: 181 GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPR-VRPR 239 Query: 382 RKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATS 441 R+ ++ V R + ++A ALG FVP + L+ Y ++ + LL +G Sbjct: 240 RRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVD 299 Query: 442 GLGRLVSGHISDSIPGLKKI-----YLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGL 496 + R G ++ GL ++ YL L+ L GL + R +G L+ C+ GL Sbjct: 300 IVARPACG----ALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGL 355 Query: 497 CDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYF 556 G + + VG + A+G +L + A ++ GPP AG L + +Y + FY Sbjct: 356 SYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYL 415 Query: 557 AGVPPIIGAVIL 568 AG + V + Sbjct: 416 AGSEVALAGVFM 427 >gi|42475555 monocarboxylate transporter 13 [Homo sapiens] Length = 426 Score = 162 bits (410), Expect = 8e-40 Identities = 115/414 (27%), Positives = 201/414 (48%), Gaps = 27/414 (6%) Query: 163 ARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGA 222 AR +PP+GG+GWVVV +A + + +FG+ S G+ + + +E+ +V +W+ + Sbjct: 2 ARRTEPPDGGWGWVVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARV----SWIAS 57 Query: 223 LAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCG 282 + + + F SP+ S + + G R G +A +G+ +SF +SL+ Y + G+L G G Sbjct: 58 IGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSG 117 Query: 283 CSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLST 342 + F P+L L YF RR LA G+ G + S +F + L + ++S Sbjct: 118 WALTFAPTLACLSCYFSRRRSLATGLALTGVGLSSFTFAPFFQWLLSHYAWRGSLLLVSA 177 Query: 343 FMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGI 402 L+ RP PS + P+ G R AQL + F + T + Sbjct: 178 LSLHLVACGALLRP--PSLAEDPAVGGPR-------AQLTSLLHHGPFLRYT-----VAL 223 Query: 403 AAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIY 462 GYF+PY+HL+ ++++ + LL + + +GR+VSG + D++PG Sbjct: 224 TLINTGYFIPYLHLVAHLQDLDWDPLPAAFLLSVVAISDLVGRVVSGWLGDAVPG-PVTR 282 Query: 463 LQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAF----ELVGPMQA 518 L +L L G+ + P+ + L+ + + G G +AP+AF EL+G + Sbjct: 283 LLMLWTTLTGVSLALFPVAQAPTALVALAVAYGFTSG----ALAPLAFSVLPELIGTRRI 338 Query: 519 SQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVP 572 +G L + ++ + GPP++G LR+ G+Y +F AG + G+ IL +P Sbjct: 339 YCGLGLLQMIESIGGLLGPPLSGYLRDVTGNYTASFVVAGAFLLSGSGILLTLP 392 >gi|23503293 solute carrier family 16, member 11 [Homo sapiens] Length = 471 Score = 154 bits (388), Expect = 3e-37 Identities = 129/458 (28%), Positives = 200/458 (43%), Gaps = 33/458 (7%) Query: 155 PTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVE 214 PT +T T + PP+GG+GWVV AA NG +G+ S+G+ + L E + Sbjct: 19 PTPQTAMTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAEHFDRSAQDT- 77 Query: 215 FQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFT 274 AW+ ALA+ + SP+ S + R G R G +A +G S+F S L Y Sbjct: 78 ---AWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLG 134 Query: 275 YGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLA 334 G+L G G + F P+L L YF RR LA G+ G+ S+ +++L D Sbjct: 135 LGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWR 194 Query: 335 QTFQVLSTFMFVLMLLSLTYRPL-LPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQR 393 +L L PL LP P + + L + +F +R Sbjct: 195 GALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAAL------------GLSLFTRR 242 Query: 394 TYRIWAFGIAAAALGYFVPYVHLMKY-VEEEFSEIKETWVLLVCIGATSGLGRLVSGHIS 452 + I+A G A GYFVPYVHL + ++ V+ V +G RLV G ++ Sbjct: 243 AFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAG-ARLVCGWLA 301 Query: 453 DS----IPGLKKIY--LQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMA 506 D +P L ++ L L ++GL+ ++ G L+ + GL G + ++ Sbjct: 302 DQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAPLVF 361 Query: 507 PIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAV 566 + LVG QA G ++ +M+L + GPP++G LR+ GD+ +F +G + G+ Sbjct: 362 GVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLILSGSF 421 Query: 567 ILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLP 604 I +P + A P GELLP Sbjct: 422 IYIGLP--------RALPSCGPASPPATPPPETGELLP 451 >gi|157041233 solute carrier family 16 (monocarboxylic acid transporters), member 12 [Homo sapiens] Length = 486 Score = 150 bits (379), Expect = 3e-36 Identities = 116/464 (25%), Positives = 205/464 (44%), Gaps = 40/464 (8%) Query: 163 ARGFQPPEGGFGWVVV---FAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAW 219 AR PP+GG+GW++V F T C +V S+ E + Q Q AW Sbjct: 7 ARSTSPPDGGWGWMIVAGCFLVTICT-------RAVTRCISIFFVEFQTYFTQDYAQTAW 59 Query: 220 VGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILF 279 + ++ + C+P+ S+ ++ L C++ G +A GL SSF +SL Y T G+L Sbjct: 60 IHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLT 119 Query: 280 GCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQV 339 G G + + P++ ++G YF RR LA G+ +GS I + ++++L ++ + Sbjct: 120 GLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLI 179 Query: 340 LSTFMFVLMLLSLTYRPL-LPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRT---- 394 L F+ L + RP+ L TP + V + + ++ Y ++ +T Sbjct: 180 LGGFVLNLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVSPYSSLTKEWAQTCLCC 239 Query: 395 -------------YRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATS 441 + + A + A G +V+L+ Y ++ L+ +G Sbjct: 240 CLQQEYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVID 299 Query: 442 GLGRLVSGHISDSIPGLKKIYLQVLSFLLL---GLMSMMIPLCRDFGGLIVVCLFLGLCD 498 +G + G ++D K Y V + GL + +P+ + L+ G D Sbjct: 300 IIGNITFGWLTDR--RCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFD 357 Query: 499 GFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAG 558 G ++T++ + E+VG S A+G + + A+P + PPIAG L + G Y AF G Sbjct: 358 GAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCG 417 Query: 559 VPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGEL 602 I +V+L F L+ +RM K + + +A + DP +L Sbjct: 418 FSMIFSSVLLGFARLI-KRMRKTQL------QFIAKESDPKLQL 454 >gi|4759116 solute carrier family 16, member 5 [Homo sapiens] Length = 505 Score = 144 bits (364), Expect = 2e-34 Identities = 105/412 (25%), Positives = 186/412 (45%), Gaps = 21/412 (5%) Query: 170 EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIF 229 +G + WVV+ A G G +GI ++ L E + N + +W ++ ++ Sbjct: 9 DGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWEFQASNSET----SWFPSILTAVLH 64 Query: 230 FCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQP 289 P+ SI R GCR+T G +A +G+ SSF+ +LS YFT G + G G F+FQ Sbjct: 65 MAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQS 124 Query: 290 SLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLML 349 S+ +LG YF RR LAN + S G S+ +P L R L + + TF V + Sbjct: 125 SITVLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCI 184 Query: 350 LSLTYRPLL-----------PSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRT-YRI 397 RP+ P +TP+ + + ++++ + R T Y + Sbjct: 185 CGAIIRPVATSVAPETKECPPPPPETPALGCLAACGR----TIQRHLAFDILRHNTGYCV 240 Query: 398 WAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIP- 456 + G+ + LG+ +P V L+ Y + ++ +L+ IG ++ R ++G ++ Sbjct: 241 YILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAF 300 Query: 457 GLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPM 516 + YL L+ LL GL +++ DF L+ CL + ++ + ++V Sbjct: 301 ASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMD 360 Query: 517 QASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL 568 Q +A+G + L + PP+AGLL + ++ FY + I A+ + Sbjct: 361 QFPRALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 412 >gi|41327156 solute carrier family 16 (monocarboxylic acid transporters), member 14 [Homo sapiens] Length = 510 Score = 141 bits (356), Expect = 2e-33 Identities = 112/482 (23%), Positives = 205/482 (42%), Gaps = 75/482 (15%) Query: 170 EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIF 229 +GG+ W++V ++ + + I G ++G+L LEE Q AWV +L+MG+ Sbjct: 29 DGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEF----HQSRGLTAWVSSLSMGITL 84 Query: 230 FCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQP 289 P + +F + GCR TA G V +G S++ +++ + T+G+ G G A+ P Sbjct: 85 IVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLP 144 Query: 290 SLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLML 349 ++V++G YFQ+R LA G+ + G+ + L++ L + + L + Sbjct: 145 AVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCV 204 Query: 350 LSLTYRPLLP-SSQDTPSKRGVRTL----------------------------------- 373 RPL P + + P ++ VR L Sbjct: 205 CGALMRPLSPGKNPNDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQA 264 Query: 374 --------HQRFLAQLR-----KYFNMRV-----------------FRQRTYRIWAFGIA 403 H++ + LR + MRV F R + + F Sbjct: 265 QECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWAL 324 Query: 404 AAALGYFVPYVHLMKYVE-EEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIY 462 A + +P++HL + V SE + + L I G+++ G I+D +P + Sbjct: 325 FAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIAD-LPCISVWN 383 Query: 463 LQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAI 522 + +L+ L L ++PL + GL V+C +G G+F ++M + +LVG + A Sbjct: 384 VFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYF-SLMPVVTEDLVGIEHLANAY 442 Query: 523 GYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKE 582 G ++ + + GPP AG + + Y +FY G+ +IG + L P + R+ ++ Sbjct: 443 GIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQPCI--RIIEQS 500 Query: 583 QR 584 +R Sbjct: 501 RR 502 >gi|169217968 PREDICTED: similar to solute carrier family 16, member 5 [Homo sapiens] Length = 453 Score = 124 bits (310), Expect = 3e-28 Identities = 92/349 (26%), Positives = 160/349 (45%), Gaps = 17/349 (4%) Query: 233 PIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLV 292 P+ SI R GCR+T G +A +G+ SSF+ +LS YFT G + G G F+FQ S+ Sbjct: 16 PLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSIT 75 Query: 293 ILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSL 352 +LG YF RR LAN + S G S+ +P L R L + + TF V + Sbjct: 76 VLGFYFVRRRVLANALASMGVSLGITLWPLLSRYLLENLGWRGTFLVFGGIFLHCCICGA 135 Query: 353 TYRPLL-----------PSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRT-YRIWAF 400 RP+ P +TP+ + + ++++ + R T Y ++ Sbjct: 136 IIRPVATSVAPETKECPPPPPETPALGCLAACGR----TIQRHLAFDILRHNTGYCVYIL 191 Query: 401 GIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIP-GLK 459 G+ + LG+ +P V L+ Y + ++ +L+ IG ++ R ++G ++ Sbjct: 192 GVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALLISIIGFSNIFLRPLAGLMAGRPAFASH 251 Query: 460 KIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQAS 519 + YL L+ LL GL +++ DF L+ CL + ++ + ++V Q Sbjct: 252 RKYLFSLALLLNGLTNLVCAASGDFWVLVGYCLAYSVSMSGIGALIFQVLMDIVPMDQFP 311 Query: 520 QAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVIL 568 +A+G + L + PP+AGLL + ++ FY + I A+ + Sbjct: 312 RALGLFTVLDGLAFLISPPLAGLLLDATNNFSYVFYMSSFFLISAALFM 360 >gi|34916028 solute carrier family 16 (monocarboxylic acid transporters), member 9 [Homo sapiens] Length = 509 Score = 101 bits (252), Expect = 2e-21 Identities = 67/210 (31%), Positives = 101/210 (48%), Gaps = 6/210 (2%) Query: 169 PEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMI 228 P+GG+GWV+VF + +G +VG+LY L+ E + AWVG+LA G+ Sbjct: 7 PDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKT----AWVGSLASGVG 62 Query: 229 FFCSPIVSIFTDRLGCR-ITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAF 287 SP+ S+ G R +T +G VA GL SSF ++ +F+YGI+ G GC + Sbjct: 63 LLASPVCSLCVSSFGARPVTIFSGFMVAG-GLMLSSFAPNIYFLFFSYGIVVGLGCGLLY 121 Query: 288 QPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVL 347 ++ I YF R GLA G++S GSS+ + L RML + L ++ + Sbjct: 122 TATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNI 181 Query: 348 MLLSLTYRPLLPSSQDTPSKRGVRTLHQRF 377 + RPL S P K L ++ Sbjct: 182 LACGSLMRPLQSSDCPLPKKIAPEDLPDKY 211 Score = 65.1 bits (157), Expect = 2e-10 Identities = 49/187 (26%), Positives = 89/187 (47%), Gaps = 5/187 (2%) Query: 389 VFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWV--LLVCIGATSGLGRL 446 +F+ + + I +G F P + LM+ V + +E ++ L+ IG + +G+L Sbjct: 300 LFKNKVFSALFIAILLFDIGGFPPSL-LMEDVARSSNVKEEEFIMPLISIIGIMTAVGKL 358 Query: 447 VSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMA 506 + G ++D + +YL V + +++GL IP + + L ++ LG G + +I Sbjct: 359 LLGILAD-FKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNW-SIFP 416 Query: 507 PIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAV 566 + + VG + + A G L+ L GPPI G + Y +AFYF+G ++G Sbjct: 417 YVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGF 476 Query: 567 ILFFVPL 573 IL L Sbjct: 477 ILLLAAL 483 >gi|40789261 solute carrier family 16, member 6 [Homo sapiens] Length = 523 Score = 93.6 bits (231), Expect = 5e-19 Identities = 95/458 (20%), Positives = 187/458 (40%), Gaps = 60/458 (13%) Query: 169 PEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMI 228 P+GG+GW V + + +GI + G+ ++ L++ E N ++ +W+ ++ + ++ Sbjct: 19 PDGGWGWAVAVSFFFVEVFTYGIIKTFGVFFNDLMDSFNESNSRI----SWIISICVFVL 74 Query: 229 FFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFG-------- 280 F +P+ ++ ++R G R+ G + G+ +SF+ +S Y GI+ G Sbjct: 75 TFSAPLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFL 134 Query: 281 -------------------------CGCSFAFQPSLVILGHYFQRRLGLAN-GVVSAGSS 314 C FAF P+++ L R L G++ Sbjct: 135 PTVTILSQYFGKRRSIVTAVASTGECFAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIV 194 Query: 315 IF-SMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRT- 372 IF ++ P IR + Q + + +M + + + T S + V T Sbjct: 195 IFGALLRPIFIRGPASPKIVIQENRKEAQYMLENEKTRTSIDSIDSGVELTTSPKNVPTH 254 Query: 373 --LHQRFLAQLRKYF---------------NMRVFRQRTYRIWAFGIAAAALGYFVPYVH 415 L A +++ + + +++++ +A A LG+F P ++ Sbjct: 255 TNLELEPKADMQQVLVKTSPRPSEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLY 314 Query: 416 LMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMS 475 ++ + LL + GR+ +G + + P ++KIY++++ +LL + Sbjct: 315 IIPLGISLGIDQDRAAFLLSTMAIAEVFGRIGAGFVLNREP-IRKIYIELICVILLTVSL 373 Query: 476 MMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFE--LVGPMQASQAIGYLLGMMALPM 533 +F GL+ +F G G P+ E +VG + S A G + + ++ Sbjct: 374 FAFTFATEFWGLMSCSIFFGFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAG 433 Query: 534 IAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFV 571 +AGPP+AGLL + Y AFY + AV L V Sbjct: 434 LAGPPLAGLLVDQSKIYSRAFYSCAAGMALAAVCLALV 471 >gi|4759114 solute carrier family 16, member 4 [Homo sapiens] Length = 487 Score = 84.7 bits (208), Expect = 2e-16 Identities = 46/192 (23%), Positives = 98/192 (51%), Gaps = 1/192 (0%) Query: 382 RKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATS 441 ++ F++ +FR + I+ + + L YF+P HL+ + +I + L+ G Sbjct: 288 KQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILE 347 Query: 442 GLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFF 501 + +++SG ++D +KK + +L G+ +++ PL F L+ + + G + Sbjct: 348 TVSQIISGWVADQ-NWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGY 406 Query: 502 ITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPP 561 + ++ P+ +L ++ +G + +++GPPIAG L + Y+ +FYF+G+ Sbjct: 407 LALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICY 466 Query: 562 IIGAVILFFVPL 573 ++ +V FFVPL Sbjct: 467 LLSSVSFFFVPL 478 Score = 81.3 bits (199), Expect = 2e-15 Identities = 44/153 (28%), Positives = 79/153 (51%), Gaps = 4/153 (2%) Query: 170 EGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIF 229 +GG+GW++V N + G+ + I + + EE + + Q+ W+G++ + F Sbjct: 16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQI----GWIGSIMSSLRF 71 Query: 230 FCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQP 289 P+V+I D LG + T+ GA V G SS+ +S+ T G+L G G +F +Q Sbjct: 72 CAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLPGLGSAFLYQV 131 Query: 290 SLVILGHYFQRRLGLANGVVSAGSSIFSMSFPF 322 + V+ YF++RL L+ + +G + + PF Sbjct: 132 AAVVTTKYFKKRLALSTAIARSGMGLTFLLAPF 164 >gi|62000702 diacylglycerol kinase kappa [Homo sapiens] Length = 1271 Score = 71.2 bits (173), Expect = 3e-12 Identities = 52/152 (34%), Positives = 64/152 (42%), Gaps = 32/152 (21%) Query: 36 GGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEE---------AK 86 G + + ++PP + + P P +PP A L S+AS E A Sbjct: 4 GAAAAQGTAPPQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAP 63 Query: 87 GPWQEADQEQQ-------------EPVG--SPEPESEPEPEPEPEPVPVPPPEPQPE--P 129 GP EA E EP +PEP +EP PEP EP P P PEP E P Sbjct: 64 GPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAP 123 Query: 130 QPLPDPA------PLPELEFESERVHEPEPTP 155 +P P+PA P PEL E PEPTP Sbjct: 124 EPTPEPALESVPEPAPELTPEVAPELAPEPTP 155 Score = 55.5 bits (132), Expect = 1e-07 Identities = 42/118 (35%), Positives = 52/118 (44%), Gaps = 15/118 (12%) Query: 46 PSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEP 105 P ++S S+ Y + P + PA+ A+E A P A + EP P Sbjct: 67 PEATSESATELYTEPT----PEPATEPASEPAPEPATEPAPEP---ATEPAPEPAPEPAT 119 Query: 106 ESEPEPEPE------PEPVPVPPPEPQPEPQPLPDPAPLPEL--EFESERVHEPEPTP 155 ES PEP PE PEP P PE PE P P P P+ EL EF E E P+P Sbjct: 120 ESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEFCPEAAPEFRPSP 177 Score = 38.5 bits (88), Expect = 0.018 Identities = 30/105 (28%), Positives = 39/105 (37%), Gaps = 11/105 (10%) Query: 66 PSSHSPPAAMALQSQASEEAKGPWQEADQE-----------QQEPVGSPEPESEPEPEPE 114 P + PA A+E A P E E + P +PEP EP E Sbjct: 103 PEPATEPAPEPAPEPATESAPEPTPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELA 162 Query: 115 PEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVET 159 PE P PE +P P P P+ E + P P+P+ T Sbjct: 163 PEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSPSPSPSPSPRT 207 >gi|4505419 nucleolar protein 3 [Homo sapiens] Length = 208 Score = 61.6 bits (148), Expect = 2e-09 Identities = 38/117 (32%), Positives = 49/117 (41%), Gaps = 6/117 (5%) Query: 28 SWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKG 87 +W + G G S PP + P++ SG + P A E Sbjct: 90 AWDWQHVGPGYRDRSYDPPCPGH------WTPEAPGSGTTCPGLPRASDPDEAGGPEGSE 143 Query: 88 PWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFE 144 Q E+ EP E E EPEPEPEP P E +PEP+ P+P P PE +FE Sbjct: 144 AVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFE 200 Score = 31.2 bits (69), Expect = 2.9 Identities = 19/55 (34%), Positives = 22/55 (40%) Query: 116 EPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPE 170 +P PE Q P PELE E+ + EPEP P E A PE Sbjct: 132 DPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPE 186 >gi|4826998 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) [Homo sapiens] Length = 707 Score = 59.7 bits (143), Expect = 8e-09 Identities = 45/134 (33%), Positives = 51/134 (38%), Gaps = 29/134 (21%) Query: 17 SRDRLSRDGLASWGAEPGGGGSGSGS-----SSPPSSSSCSSRNKYQPQSGSSGPSSHSP 71 SRDR G G GGG G G S PP +R P G SGP P Sbjct: 2 SRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIP 61 Query: 72 PAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVP----VPPPEPQP 127 P P Q Q+QQ P P P+ P +P P P P PPP PQ Sbjct: 62 PPP-------------PHQ---QQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQD 105 Query: 128 EPQPL----PDPAP 137 +P+ P PAP Sbjct: 106 SSKPVVAQGPGPAP 119 >gi|83977459 pleckstrin homology-like domain, family A, member 1 [Homo sapiens] Length = 401 Score = 57.0 bits (136), Expect = 5e-08 Identities = 20/42 (47%), Positives = 30/42 (71%) Query: 96 QQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAP 137 QQ+P P+P+ + +P+P+P+P P P P+ QP+PQP P P P Sbjct: 304 QQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQP 345 Score = 55.8 bits (133), Expect = 1e-07 Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 5/71 (7%) Query: 90 QEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPA-----PLPELEFE 144 Q Q+Q P+P+ +P+P+P+P+P P P +PQP+PQP P P P P Sbjct: 300 QHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPH 359 Query: 145 SERVHEPEPTP 155 S P P P Sbjct: 360 SHPHSHPHPHP 370 Score = 55.1 bits (131), Expect = 2e-07 Identities = 23/66 (34%), Positives = 43/66 (65%), Gaps = 3/66 (4%) Query: 91 EADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHE 150 ++ +++Q+ + +P S+P+P+P+ +P P P P+PQP+PQ P P P P+ + +++H Sbjct: 293 KSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKP--QPQQLHP 350 Query: 151 -PEPTP 155 P P P Sbjct: 351 YPHPHP 356 Score = 55.1 bits (131), Expect = 2e-07 Identities = 27/88 (30%), Positives = 41/88 (46%), Gaps = 3/88 (3%) Query: 77 LQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPV---PPPEPQPEPQPLP 133 +Q Q + + Q Q Q +P P+P+S+P+P+P+P+P P P P P P P P Sbjct: 303 VQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHP 362 Query: 134 DPAPLPELEFESERVHEPEPTPTVETRG 161 P P ++ P P P + G Sbjct: 363 HSHPHPHPHPHPHQIPHPHPQPHSQPHG 390 Score = 49.3 bits (116), Expect = 1e-05 Identities = 29/100 (29%), Positives = 38/100 (38%), Gaps = 3/100 (3%) Query: 52 SSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPE---PESE 108 S+R K Q PS P + Q Q + + Q Q Q +P P+ P Sbjct: 294 STRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPH 353 Query: 109 PEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERV 148 P P P P P P P P P +P P P P + R+ Sbjct: 354 PHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRL 393 >gi|116284398 WAS/WASL interacting protein family, member 1 [Homo sapiens] Length = 503 Score = 55.1 bits (131), Expect = 2e-07 Identities = 53/189 (28%), Positives = 67/189 (35%), Gaps = 48/189 (25%) Query: 2 GRGGGGLDVGGGGEGSRDRLSRDGLASWGAEPGGGGSGS-GSSSPPSSSSC--------- 51 G GGGG GGGG +G GGGG GS G PP Sbjct: 66 GAGGGGGGFGGGG-------------GFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLR 112 Query: 52 SSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEP 111 S+ N+ GS P PP + ++ GP + PV SP S P P Sbjct: 113 STANRDNDSGGSRPPLL--PPGGRSTSAKPFSPPSGPGRF-------PVPSPGHRSGP-P 162 Query: 112 EPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHE---------------PEPTPT 156 EP+ +P P P+ +P +P P P +S + P P P Sbjct: 163 EPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPF 222 Query: 157 VETRGTARG 165 RGTA G Sbjct: 223 PGNRGTALG 231 Score = 39.3 bits (90), Expect = 0.011 Identities = 35/121 (28%), Positives = 43/121 (35%), Gaps = 2/121 (1%) Query: 37 GSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQ 96 G GS SP SSSS S P + S PP + ++ S + Q Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNN 290 Query: 97 QEPVGSPEPESEPEPEPEPEPVPV-PPPEPQPEPQPLPDPAP-LPELEFESERVHEPEPT 154 + PV S S P P P P P P P P D P LP+ P P+ Sbjct: 291 KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS 350 Query: 155 P 155 P Sbjct: 351 P 351 Score = 36.2 bits (82), Expect = 0.091 Identities = 58/235 (24%), Positives = 69/235 (29%), Gaps = 84/235 (35%) Query: 2 GRGGGGLDVGGGGE-------------------------GSRDRLSRDGLASWGAEPGGG 36 G GGGG GGGG GSR L G S A+P Sbjct: 84 GGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSP 143 Query: 37 GSGSGSSSPPSSSSCSS-----RNKYQPQSGSSG--PSSHSPPAAMA---LQSQASEEAK 86 SG G PS S RN+ P G P S PP +QS Sbjct: 144 PSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGS 203 Query: 87 GPWQEADQE-----------------------QQEPVGSPEPESEPEP-----------E 112 P ++ +Q P+ S P S P + Sbjct: 204 PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK 263 Query: 113 PEPEPVP-----------VPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPT 156 P P P P VPPP PQ P+P P P S + P P P+ Sbjct: 264 PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS-TPRPS---ASSQAPPPPPPPS 314 Score = 34.7 bits (78), Expect = 0.26 Identities = 25/97 (25%), Positives = 32/97 (32%) Query: 42 SSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVG 101 ++ PP S+ Q PS PP S E + P + P Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPL 348 Query: 102 SPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPL 138 S P P P E P P +P PLP P P+ Sbjct: 349 PSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV 385 >gi|38373695 WAS/WASL interacting protein family, member 1 [Homo sapiens] Length = 503 Score = 55.1 bits (131), Expect = 2e-07 Identities = 53/189 (28%), Positives = 67/189 (35%), Gaps = 48/189 (25%) Query: 2 GRGGGGLDVGGGGEGSRDRLSRDGLASWGAEPGGGGSGS-GSSSPPSSSSC--------- 51 G GGGG GGGG +G GGGG GS G PP Sbjct: 66 GAGGGGGGFGGGG-------------GFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLR 112 Query: 52 SSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEP 111 S+ N+ GS P PP + ++ GP + PV SP S P P Sbjct: 113 STANRDNDSGGSRPPLL--PPGGRSTSAKPFSPPSGPGRF-------PVPSPGHRSGP-P 162 Query: 112 EPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHE---------------PEPTPT 156 EP+ +P P P+ +P +P P P +S + P P P Sbjct: 163 EPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPF 222 Query: 157 VETRGTARG 165 RGTA G Sbjct: 223 PGNRGTALG 231 Score = 39.3 bits (90), Expect = 0.011 Identities = 35/121 (28%), Positives = 43/121 (35%), Gaps = 2/121 (1%) Query: 37 GSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQ 96 G GS SP SSSS S P + S PP + ++ S + Q Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNN 290 Query: 97 QEPVGSPEPESEPEPEPEPEPVPV-PPPEPQPEPQPLPDPAP-LPELEFESERVHEPEPT 154 + PV S S P P P P P P P P D P LP+ P P+ Sbjct: 291 KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS 350 Query: 155 P 155 P Sbjct: 351 P 351 Score = 36.2 bits (82), Expect = 0.091 Identities = 58/235 (24%), Positives = 69/235 (29%), Gaps = 84/235 (35%) Query: 2 GRGGGGLDVGGGGE-------------------------GSRDRLSRDGLASWGAEPGGG 36 G GGGG GGGG GSR L G S A+P Sbjct: 84 GGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSP 143 Query: 37 GSGSGSSSPPSSSSCSS-----RNKYQPQSGSSG--PSSHSPPAAMA---LQSQASEEAK 86 SG G PS S RN+ P G P S PP +QS Sbjct: 144 PSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGS 203 Query: 87 GPWQEADQE-----------------------QQEPVGSPEPESEPEP-----------E 112 P ++ +Q P+ S P S P + Sbjct: 204 PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK 263 Query: 113 PEPEPVP-----------VPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPT 156 P P P P VPPP PQ P+P P P S + P P P+ Sbjct: 264 PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS-TPRPS---ASSQAPPPPPPPS 314 Score = 34.7 bits (78), Expect = 0.26 Identities = 25/97 (25%), Positives = 32/97 (32%) Query: 42 SSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVG 101 ++ PP S+ Q PS PP S E + P + P Sbjct: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPL 348 Query: 102 SPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPL 138 S P P P E P P +P PLP P P+ Sbjct: 349 PSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV 385 >gi|55741677 SET domain containing 1A [Homo sapiens] Length = 1707 Score = 54.3 bits (129), Expect = 3e-07 Identities = 45/162 (27%), Positives = 63/162 (38%), Gaps = 23/162 (14%) Query: 15 EGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAA 74 +G D S +S + S S SSS SSS SS ++ + + ++ PS+ PP Sbjct: 1024 DGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPRE 1083 Query: 75 MALQSQASEEAKGPWQ----------EADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPE 124 + + + A E P + E + P G E P PEP P PP Sbjct: 1084 VPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEP-PAGPPA 1142 Query: 125 PQPEPQPLPDPAPLPELEFESER-----------VHEPEPTP 155 P P P P +P+P L +R V PEP P Sbjct: 1143 PAPRPDERPS-SPIPLLPPPKKRRKTVSFSAIEVVPAPEPPP 1183 Score = 51.2 bits (121), Expect = 3e-06 Identities = 42/146 (28%), Positives = 58/146 (39%), Gaps = 7/146 (4%) Query: 15 EGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAA 74 E + D ++ S G + S S S S + + S SS SS S ++ Sbjct: 991 EEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSS 1050 Query: 75 MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVP------PPEPQPE 128 + S +SE + +E ++ P SP P P P P P VPVP P P PE Sbjct: 1051 SSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPE 1110 Query: 129 PQPLP-DPAPLPELEFESERVHEPEP 153 + P PA E S + PEP Sbjct: 1111 QEASPARPAGPTEESPPSAPLRPPEP 1136 Score = 48.9 bits (115), Expect = 1e-05 Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 5/103 (4%) Query: 37 GSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQ 96 GSG G +PP + + + + SG G + SP A Q+QAS + G E + Sbjct: 533 GSGHGPCTPPPAPA-NFEDVAPTGSGEPGATRESPKANG--QNQASPCSSGDDMEISDDD 589 Query: 97 QEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLP 139 + GSP P P +P P P P PPP P PL P P Sbjct: 590 RG--GSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQP 630 Score = 47.4 bits (111), Expect = 4e-05 Identities = 36/131 (27%), Positives = 49/131 (37%), Gaps = 10/131 (7%) Query: 47 SSSSCS------SRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPV 100 SSS CS N S SS SS S ++ + S +S + E ++E++ P Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPA 1072 Query: 101 GSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETR 160 P P P PVP P P P P+ + P E E+ PT Sbjct: 1073 ALPSAS----PPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPS 1128 Query: 161 GTARGFQPPEG 171 R +PP G Sbjct: 1129 APLRPPEPPAG 1139 Score = 41.2 bits (95), Expect = 0.003 Identities = 53/177 (29%), Positives = 71/177 (40%), Gaps = 15/177 (8%) Query: 38 SGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQ 97 S S SSS SSSS SS + Q SS + PA ++ P + A +E Sbjct: 336 SSSASSSSLSSSSSSSSSSSSSQFRSSDANY---PAYYESWNRYQRHTSYPPRRATRE-- 390 Query: 98 EPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQ---PLPDPAPLPELEFESERVHEPEPT 154 EP G+P E+ E P +PP +P Q P AP PE P+ Sbjct: 391 EPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPS 450 Query: 155 P-TVETRGTARGFQPPEGGFGWVVVFAATWCNGSI-FGIHNSVGILYSMLLEEEKEK 209 P E R + R P G A N S+ F H+S+ MLL+E++ K Sbjct: 451 PEREEVRTSPRPASPARSGSP-----APETTNESVPFAQHSSLDSRIEMLLKEQRSK 502 Score = 38.1 bits (87), Expect = 0.024 Identities = 39/178 (21%), Positives = 49/178 (27%), Gaps = 72/178 (40%) Query: 32 EPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQ---------AS 82 EPGGGG G G S S R +SGS P + + A S Sbjct: 439 EPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKE 498 Query: 83 EEAKGPWQEADQEQQE----------------PVGSPEPESEPEPEP------------- 113 + +K + +D E++E P GS P P P Sbjct: 499 QRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGE 558 Query: 114 ----------------------------------EPEPVPVPPPEPQPEPQPLPDPAP 137 P P P PP +P P P P P P P Sbjct: 559 PGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPP 616 Score = 35.4 bits (80), Expect = 0.16 Identities = 29/112 (25%), Positives = 42/112 (37%), Gaps = 36/112 (32%) Query: 64 SGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVP-VPP 122 +GP+ SPP+A + + P G P P P+ P P+P +PP Sbjct: 1119 AGPTEESPPSAPL-----------------RPPEPPAGPPAPAPRPDERPS-SPIPLLPP 1160 Query: 123 PEPQPE----------PQPLPDPAPLPELEFESERVHEPEPTPTVETRGTAR 164 P+ + + P P P PA P+ +F P P RG R Sbjct: 1161 PKKRRKTVSFSAIEVVPAPEPPPATPPQAKF-------PGPASRKAPRGVER 1205 >gi|24307909 ral guanine nucleotide dissociation stimulator isoform 1 [Homo sapiens] Length = 914 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 13/102 (12%) Query: 69 HSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVP------P 122 HS P ++ + A P E + P +P P P PEPEP P P P Sbjct: 250 HSEPIEAEPEALSPVPALKPTPELELALT-PARAPSPVPAPAPEPEPAPTPAPGSELEVA 308 Query: 123 PEPQPEPQPLPDPA------PLPELEFESERVHEPEPTPTVE 158 P P PE Q P+PA P P LE E +P P+ T+E Sbjct: 309 PAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLE 350 Score = 48.5 bits (114), Expect = 2e-05 Identities = 29/73 (39%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Query: 91 EADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEF----ESE 146 EA+ E PV + +P E E P P P P P PEP+P P PAP ELE E Sbjct: 255 EAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPE 314 Query: 147 RVHEPEPTPTVET 159 PEP +E+ Sbjct: 315 LQQAPEPAVGLES 327 Score = 43.5 bits (101), Expect = 6e-04 Identities = 30/82 (36%), Positives = 35/82 (42%), Gaps = 26/82 (31%) Query: 99 PVGSPEPESEPEPEPEP----EPVPVPPPE----PQP--------------EPQPLPDPA 136 PV +P PE EP P P P E P P PE P+P EP P DPA Sbjct: 285 PVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPA 344 Query: 137 PLPELEFESERVHEPEPTPTVE 158 P LE E P P P+++ Sbjct: 345 PSQTLELEP----APAPVPSLQ 362 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/75 (33%), Positives = 31/75 (41%), Gaps = 3/75 (4%) Query: 66 PSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVG---SPEPESEPEPEPEPEPVPVPP 122 P+ PA E A P E Q + VG +P P E EP PE +P P Sbjct: 289 PAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQT 348 Query: 123 PEPQPEPQPLPDPAP 137 E +P P P+P P Sbjct: 349 LELEPAPAPVPSLQP 363 Score = 33.9 bits (76), Expect = 0.45 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 10/64 (15%) Query: 92 ADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEP 151 A E EP+ + P P +P P P P P+P PAP P EP Sbjct: 246 AQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEP----------EP 295 Query: 152 EPTP 155 PTP Sbjct: 296 APTP 299 >gi|108796058 ral guanine nucleotide dissociation stimulator isoform 2 [Homo sapiens] Length = 859 Score = 54.3 bits (129), Expect = 3e-07 Identities = 35/102 (34%), Positives = 44/102 (43%), Gaps = 13/102 (12%) Query: 69 HSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVP------P 122 HS P ++ + A P E + P +P P P PEPEP P P P Sbjct: 195 HSEPIEAEPEALSPVPALKPTPELELALT-PARAPSPVPAPAPEPEPAPTPAPGSELEVA 253 Query: 123 PEPQPEPQPLPDPA------PLPELEFESERVHEPEPTPTVE 158 P P PE Q P+PA P P LE E +P P+ T+E Sbjct: 254 PAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLE 295 Score = 48.5 bits (114), Expect = 2e-05 Identities = 29/73 (39%), Positives = 35/73 (47%), Gaps = 4/73 (5%) Query: 91 EADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEF----ESE 146 EA+ E PV + +P E E P P P P P PEP+P P PAP ELE E Sbjct: 200 EAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPE 259 Query: 147 RVHEPEPTPTVET 159 PEP +E+ Sbjct: 260 LQQAPEPAVGLES 272 Score = 43.5 bits (101), Expect = 6e-04 Identities = 30/82 (36%), Positives = 35/82 (42%), Gaps = 26/82 (31%) Query: 99 PVGSPEPESEPEPEPEP----EPVPVPPPE----PQP--------------EPQPLPDPA 136 PV +P PE EP P P P E P P PE P+P EP P DPA Sbjct: 230 PVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPA 289 Query: 137 PLPELEFESERVHEPEPTPTVE 158 P LE E P P P+++ Sbjct: 290 PSQTLELEP----APAPVPSLQ 307 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/75 (33%), Positives = 31/75 (41%), Gaps = 3/75 (4%) Query: 66 PSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVG---SPEPESEPEPEPEPEPVPVPP 122 P+ PA E A P E Q + VG +P P E EP PE +P P Sbjct: 234 PAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQT 293 Query: 123 PEPQPEPQPLPDPAP 137 E +P P P+P P Sbjct: 294 LELEPAPAPVPSLQP 308 Score = 33.9 bits (76), Expect = 0.45 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 10/64 (15%) Query: 92 ADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEP 151 A E EP+ + P P +P P P P P+P PAP P EP Sbjct: 191 AQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEP----------EP 240 Query: 152 EPTP 155 PTP Sbjct: 241 APTP 244 >gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] Length = 2400 Score = 52.4 bits (124), Expect = 1e-06 Identities = 46/157 (29%), Positives = 62/157 (39%), Gaps = 33/157 (21%) Query: 9 DVGGGGEGSRDRLSRDGLASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSS 68 + GG G G D L + A +PG G +P + QP+S Sbjct: 1802 ETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEA------QPES------- 1848 Query: 69 HSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPES----EPEPEPEPEPVPVPPPE 124 + + EA+G QEA+ E Q PE E E E E +PE V PE Sbjct: 1849 ---------EGVEAPEAEGDAQEAEGEAQ-----PESEDVEAPEAEGEAQPESEDVETPE 1894 Query: 125 PQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRG 161 + E QP + A PE E E++ E E +ET G Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQ--PETESVEALETEG 1929 Score = 46.2 bits (108), Expect = 9e-05 Identities = 38/105 (36%), Positives = 53/105 (50%), Gaps = 7/105 (6%) Query: 62 GSSGPSSHSPPAAMALQSQASEEAKG-PWQEADQEQQ-EPVGSPEPESEPEPEPEPEPVP 119 G + P S A A + +A E++G QEA++E Q E G PE+E E +PE E + Sbjct: 2139 GEAQPESEGVEAQDA-EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIE 2197 Query: 120 VPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTAR 164 P E + E QP + PE E E++ EPE T E G A+ Sbjct: 2198 AP--EAEGEAQPELEGVEAPEAEEEAQ--PEPEGVETPEAEGEAQ 2238 Score = 43.5 bits (101), Expect = 6e-04 Identities = 38/127 (29%), Positives = 56/127 (44%), Gaps = 16/127 (12%) Query: 41 GSSSPPSSS--SCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQE 98 G + P S + + + QP+S A L+ + EA+G EA Q + E Sbjct: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEG---EA-QPESE 2194 Query: 99 PVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVE 158 + +PE E E +PE E V PE + E QP P+ PE E E+ +P E Sbjct: 2195 GIEAPEAEGEAQPELE----GVEAPEAEEEAQPEPEGVETPEAEGEA------QPESEGE 2244 Query: 159 TRGTARG 165 T+G +G Sbjct: 2245 TQGEKKG 2251 Score = 42.4 bits (98), Expect = 0.001 Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 6/121 (4%) Query: 53 SRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKG---PWQEADQEQQEPVGSPEPESEP 109 + + Q G + P S A A + +A E++G P E + ++ E + +PE E E Sbjct: 2067 AEGEVQEAEGEAHPESEDVDAQEA-EGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125 Query: 110 EPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPP 169 +PE E P E QPE + + E + ESE + E E + G + P Sbjct: 2126 QPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE--EAQPELEGVEAP 2183 Query: 170 E 170 E Sbjct: 2184 E 2184 Score = 40.0 bits (92), Expect = 0.006 Identities = 34/127 (26%), Positives = 51/127 (40%), Gaps = 10/127 (7%) Query: 27 ASWGAEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAK 86 A W +P G+ + + + S + + G P S A A +A++EA+ Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETE-GEDEPESEGAEAQEA--EEAAQEAE 1951 Query: 87 GPWQEADQEQQEPVGSPEPESEPEPEPEPE---PVPVPPPEPQPEPQPLPDPAPLPELEF 143 G Q + E + S E E E +PE E V V E + E QP + PE E Sbjct: 1952 GQ----TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG 2007 Query: 144 ESERVHE 150 E + E Sbjct: 2008 EMQEAEE 2014 Score = 39.3 bits (90), Expect = 0.011 Identities = 35/146 (23%), Positives = 58/146 (39%), Gaps = 16/146 (10%) Query: 41 GSSSPPSSS--SCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEAD---QE 95 G + P S + + + Q + P S A + + ++E +G Q+ + Q Sbjct: 1991 GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQP 2050 Query: 96 QQEPVGSPEPESEP----------EPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFES 145 + + V +PE E E E E PE V E + E QP + PE E E+ Sbjct: 2051 ESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEA 2110 Query: 146 ERVHEPE-PTPTVETRGTARGFQPPE 170 ++ E P E + + G + PE Sbjct: 2111 QKAEGIEAPETEGEAQPESEGIEAPE 2136 Score = 38.1 bits (87), Expect = 0.024 Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 2/114 (1%) Query: 58 QPQSGSSGPSSHSPPAAMAL-QSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPE 116 Q G + P S A A ++Q +E + P E + Q E G PE+E E +PE E Sbjct: 2088 QEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA-QPESEGIEAPEAEGEAQPESE 2146 Query: 117 PVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPE 170 V E + +P+ A E E + E P E + + G + PE Sbjct: 2147 GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE 2200 Score = 34.7 bits (78), Expect = 0.26 Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 6/117 (5%) Query: 58 QPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEP 117 + + + + P + ++SQ +EE P E + + V + E E E +PE E Sbjct: 1942 EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE--- 1998 Query: 118 VPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTV--ETRGTARGFQPPEGG 172 V PE + E Q + A E++ E E V ET+ T QP G Sbjct: 1999 -DVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054 >gi|156523246 proline-rich transmembrane protein 2 [Homo sapiens] Length = 340 Score = 52.4 bits (124), Expect = 1e-06 Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 23/115 (20%) Query: 59 PQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEA------DQEQQEPVGSPEPESEPEPE 112 P++G + P + PA + +QA++ + P E+ + QE V PE E + Sbjct: 63 PKAGLA-PETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATAD 121 Query: 113 ----------PEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTV 157 PEP P P P P+P+P+ QP P PA PEL + +PTP + Sbjct: 122 QGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQE------DPTPEI 170 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/114 (27%), Positives = 46/114 (40%), Gaps = 3/114 (2%) Query: 33 PGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEA 92 P G + + +P +S + G ++ SP Q S+ A Sbjct: 63 PKAGLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPC--QETVSKPEVSKEATA 120 Query: 93 DQEQQ-EPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFES 145 DQ + E PEP EP P+P+P P P P+P +P+ P PE+ ES Sbjct: 121 DQGSRLESAAPPEPAPEPAPQPDPRPDSQPTPKPALQPELPTQEDPTPEILSES 174 Score = 30.4 bits (67), Expect = 5.0 Identities = 35/142 (24%), Positives = 52/142 (36%), Gaps = 12/142 (8%) Query: 25 GLASWGAEPGGGGSGSGSSSPPS-SSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASE 83 GLA E G S + ++ S S S+ P+ S + A Q S Sbjct: 66 GLAPETTETPAGASETAQATDLSLSPGGESKANCSPEDPCQETVSKPEVSKEATADQGSR 125 Query: 84 -EAKGPWQEADQEQQEPVGSPEPESEPEPEP--------EPEPVPVPPPEPQPEPQPLPD 134 E+ P + A + +P P P+S+P P+P + +P P E E Q Sbjct: 126 LESAAPPEPAPEPAPQP--DPRPDSQPTPKPALQPELPTQEDPTPEILSESVGEKQENGA 183 Query: 135 PAPLPELEFESERVHEPEPTPT 156 PL + E EP P+ Sbjct: 184 VVPLQAGDGEEGPAPEPHSPPS 205 >gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sapiens] Length = 2715 Score = 52.0 bits (123), Expect = 2e-06 Identities = 56/195 (28%), Positives = 65/195 (33%), Gaps = 37/195 (18%) Query: 2 GRGGGGLDVGGGGEG-----SRDRLSRDGLASWGAEPGGG----------------GSGS 40 GRGG G GGG SR + + G S G E G G GSG Sbjct: 289 GRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQ 348 Query: 41 GSS-----SPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQAS-EEAKGPWQEADQ 94 G S K + + G A + A EEAK P Sbjct: 349 GGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLP----PP 404 Query: 95 EQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPT 154 P SP P P P P P PPP P P PLP P P P E + E P Sbjct: 405 PLTPPAPSPPPPLPP-PSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEE-----SPP 458 Query: 155 PTVETRGTARGFQPP 169 P V + + +PP Sbjct: 459 PVVPATCSRKRGRPP 473 Score = 40.8 bits (94), Expect = 0.004 Identities = 21/63 (33%), Positives = 23/63 (36%), Gaps = 20/63 (31%) Query: 97 QEPVGSPEPESEPEPEPEPEPVP--------------------VPPPEPQPEPQPLPDPA 136 QEP P P P P P P+P +PPP P P P P P P Sbjct: 575 QEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPP 634 Query: 137 PLP 139 P P Sbjct: 635 PAP 637 Score = 39.7 bits (91), Expect = 0.008 Identities = 32/127 (25%), Positives = 48/127 (37%), Gaps = 31/127 (24%) Query: 31 AEPGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAM--------------- 75 AE +G +SPP+ + P + + GP SP A Sbjct: 480 AEREAARAGPEGTSPPTPT---------PSTATGGPPEDSPTVAPKSTTFLKNIRQFIMP 530 Query: 76 ALQSQASEEAKGPWQEADQE-------QQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPE 128 + +++S K P + D++ + PV P + P EP PVP PP P P Sbjct: 531 VVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPP 590 Query: 129 PQPLPDP 135 P+P P Sbjct: 591 STPVPLP 597 Score = 33.1 bits (74), Expect = 0.77 Identities = 35/138 (25%), Positives = 47/138 (34%), Gaps = 36/138 (26%) Query: 58 QPQSGSSGPSSHSPPAA-MALQSQASEEAKGP---WQEADQEQQEPVGSPEPESEPEPEP 113 +P S P + +PP+ + L + + P W +E P +P P P P P Sbjct: 576 EPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPP 635 Query: 114 EP-------------------------EPVPVPPP-----EPQPEPQPLPD-PA-PLPEL 141 P E V PPP P+PEP P D PA P P Sbjct: 636 APATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRA 695 Query: 142 EFESERVHEPEPTPTVET 159 + + P P V T Sbjct: 696 VGRTNHLSLPRFAPVVTT 713 Score = 30.8 bits (68), Expect = 3.8 Identities = 23/81 (28%), Positives = 31/81 (38%), Gaps = 18/81 (22%) Query: 91 EADQEQQEPVGSPEPESEPEPEPEP---------------EPVPVPPPEPQPEPQPLPDP 135 EA +E Q V SP P SEP +P P+ P +P+ P P Sbjct: 1796 EAAEENQTIVHSPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPP 1855 Query: 136 APLPELEFESERVHEPEPTPT 156 AP F R+ P +P+ Sbjct: 1856 AP---RSFSGARIKVPNYSPS 1873 Score = 30.4 bits (67), Expect = 5.0 Identities = 25/116 (21%), Positives = 45/116 (38%), Gaps = 18/116 (15%) Query: 33 PGGGGSGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSH------SPPAAMALQSQASEEAK 86 P G PP+ S + +P+ + G ++H +P ++++ S Sbjct: 670 PLGAPEAPEPEPPPADDSPA-----EPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGA 724 Query: 87 GPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELE 142 Q Q + + +P + + +P P PQP+ QP P P +P LE Sbjct: 725 PALSNGPQTQAQLL-------QPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLE 773 Score = 30.4 bits (67), Expect = 5.0 Identities = 18/55 (32%), Positives = 25/55 (45%), Gaps = 6/55 (10%) Query: 93 DQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESER 147 D + EP G P P E E +P+P PE Q P+ P P L+ ++ R Sbjct: 1091 DSDDSEPGGPPAPRRRTPRENE---LPLPEPEEQSRPR---KPTLQPVLQLKARR 1139 Score = 29.6 bits (65), Expect = 8.5 Identities = 28/98 (28%), Positives = 39/98 (39%), Gaps = 10/98 (10%) Query: 59 PQSGSSGPSSHSPPAAMALQSQASEEAKGPW---QEADQEQQE------PVGSPE-PESE 108 P P + SPP A A S+ + P EA + E P+G+PE PE E Sbjct: 621 PPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPE 680 Query: 109 PEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESE 146 P P + P P + LP AP+ ++E Sbjct: 681 PPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAE 718 >gi|47132519 Ras association and pleckstrin homology domains 1 isoform 1 [Homo sapiens] Length = 1250 Score = 51.6 bits (122), Expect = 2e-06 Identities = 39/124 (31%), Positives = 49/124 (39%), Gaps = 22/124 (17%) Query: 38 SGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPW------QE 91 SGS SSS P S S S SG S P + QS S W +E Sbjct: 536 SGSSSSSIPESQSNHSNQS------DSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEE 589 Query: 92 ADQEQQEPVGSPEPESEPEPEPEPEPV----------PVPPPEPQPEPQPLPDPAPLPEL 141 + + + E + P P P+P+ V P+PPP P P P P P P P P L Sbjct: 590 SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL 649 Query: 142 EFES 145 +S Sbjct: 650 PSQS 653 Score = 50.1 bits (118), Expect = 6e-06 Identities = 36/121 (29%), Positives = 42/121 (34%), Gaps = 19/121 (15%) Query: 38 SGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQ 97 S S S SSSS SG S P + QS S W+ Q ++ Sbjct: 530 SSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEE 589 Query: 98 ----------EPVGSPEPESEPEP---------EPEPEPVPVPPPEPQPEPQPLPDPAPL 138 P S P P+P +P P P PPP P P P P P P PL Sbjct: 590 SSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPL 649 Query: 139 P 139 P Sbjct: 650 P 650 Score = 46.6 bits (109), Expect = 7e-05 Identities = 31/89 (34%), Positives = 38/89 (42%), Gaps = 5/89 (5%) Query: 72 PAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEP-- 129 PA +A QS + +AK WQ + P P P P P P PVP P P P P Sbjct: 887 PANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTA 946 Query: 130 QPLPDPAPLP---ELEFESERVHEPEPTP 155 P PD + P + S +P PTP Sbjct: 947 SPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975 Score = 36.2 bits (82), Expect = 0.091 Identities = 27/89 (30%), Positives = 34/89 (38%), Gaps = 18/89 (20%) Query: 71 PPAAMALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPE-- 128 PP A++SQ + P Q P +P+ +P P P P PPP P+ Sbjct: 872 PPTPPAMESQPLK----PVPANVAPQSPPAVKAKPKWQPSSIPVPSP-DFPPPPPESSLV 926 Query: 129 -PQPLPDPAPLPELEFESERVHEPEPTPT 156 P P P P P P P P PT Sbjct: 927 FPPPPPSPVPAP----------PPPPPPT 945 Score = 35.8 bits (81), Expect = 0.12 Identities = 42/161 (26%), Positives = 50/161 (31%), Gaps = 43/161 (26%) Query: 43 SSPPSSSSCSSRNKYQPQSGSSGPSSHS-----PPAAMALQSQASEEAKGPWQEADQEQQ 97 S+P + S+ KY + S HS PP +QSQ+ + Q Sbjct: 653 SAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKP---------QILV 703 Query: 98 EPVGSPEPESEPEPEPEP-------EPVP---------VPPPE-------------PQPE 128 P G P P P P P +P P PPP P Sbjct: 704 PPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTP 763 Query: 129 PQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPP 169 P P P PAPLP V P PT T PP Sbjct: 764 PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPP 804 Score = 35.0 bits (79), Expect = 0.20 Identities = 21/59 (35%), Positives = 26/59 (44%), Gaps = 11/59 (18%) Query: 105 PESEPEPEPEPEPVPVPPPE--------PQPEPQPLPDPAPLPELEFESERVHEPEPTP 155 P S P P PVPVPPP +P P PL +P+P + + P PTP Sbjct: 820 PASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPL---SPVPSVVKQIASQFPPPPTP 875 Score = 32.3 bits (72), Expect = 1.3 Identities = 29/113 (25%), Positives = 38/113 (33%), Gaps = 20/113 (17%) Query: 45 PPSSSSCSSRNKYQPQSGSSGPSSHSPPAAMALQSQASEEAKGPWQEADQEQQEPVGSPE 104 PP+ S ++ K P + S S PP Q Q + V P Sbjct: 718 PPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQ---------------VAPPT 762 Query: 105 PESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTV 157 P P P P P P+PP P +P P + + P PTP V Sbjct: 763 P-----PPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPV 810 Score = 31.6 bits (70), Expect = 2.2 Identities = 33/125 (26%), Positives = 45/125 (36%), Gaps = 10/125 (8%) Query: 38 SGSGSSSPPSSSSCSSRNKYQPQSGSSGPSSHS--PPAAMALQSQ---ASEEAKGPWQEA 92 SG+ P S S +K+ P + S PS + PPAA + + G Q+ Sbjct: 985 SGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQQG 1044 Query: 93 DQEQQEPV----GSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERV 148 + PV G P P P P PPPE + P+ PA V Sbjct: 1045 CVSAKAPVLSGRGKDSVVEFPSP-PSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVAV 1103 Query: 149 HEPEP 153 P+P Sbjct: 1104 VNPQP 1108 Score = 30.8 bits (68), Expect = 3.8 Identities = 20/69 (28%), Positives = 28/69 (40%), Gaps = 2/69 (2%) Query: 102 SPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEP-EPTPTVETR 160 +P P P + P PP P P P+P P + F ++ P P P+V + Sbjct: 805 TPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSV-VK 863 Query: 161 GTARGFQPP 169 A F PP Sbjct: 864 QIASQFPPP 872 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.139 0.431 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,898,646 Number of Sequences: 37866 Number of extensions: 1894180 Number of successful extensions: 52545 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 831 Number of HSP's successfully gapped in prelim test: 1479 Number of HSP's that attempted gapping in prelim test: 19032 Number of HSP's gapped (non-prelim): 15970 length of query: 613 length of database: 18,247,518 effective HSP length: 108 effective length of query: 505 effective length of database: 14,157,990 effective search space: 7149784950 effective search space used: 7149784950 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.