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Search of human proteins with 57164979
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
(958 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 1831 0.0
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 1822 0.0
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 1822 0.0
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 1822 0.0
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 1441 0.0
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 1441 0.0
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 149 2e-35
gi|163965366 nascent polypeptide-associated complex alpha subuni... 129 1e-29
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 115 2e-25
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 114 3e-25
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 114 3e-25
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 114 3e-25
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 114 3e-25
gi|150170670 piccolo isoform 2 [Homo sapiens] 102 1e-21
gi|150378539 piccolo isoform 1 [Homo sapiens] 102 1e-21
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 98 4e-20
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 97 7e-20
gi|112821681 G protein-regulated inducer of neurite outgrowth 1 ... 94 5e-19
gi|110832843 TBP-associated factor 4 [Homo sapiens] 94 8e-19
gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens] 91 7e-18
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 88 4e-17
gi|91982772 mucin 17 [Homo sapiens] 87 7e-17
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 87 7e-17
gi|149773456 hypothetical protein LOC643314 [Homo sapiens] 86 2e-16
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom... 85 4e-16
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom... 85 4e-16
gi|148806908 fibronectin type III domain containing 1 [Homo sapi... 83 1e-15
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens] 82 3e-15
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 79 2e-14
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens] 79 3e-14
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 1831 bits (4743), Expect = 0.0
Identities = 958/958 (100%), Positives = 958/958 (100%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV
Sbjct: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS
Sbjct: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 1822 bits (4719), Expect = 0.0
Identities = 953/953 (100%), Positives = 953/953 (100%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV
Sbjct: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ
Sbjct: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Score = 413 bits (1062), Expect = e-115
Identities = 347/973 (35%), Positives = 448/973 (46%), Gaps = 115/973 (11%)
Query: 60 GRKRKAEEDAALQAKKTRVSD-----PISTSESSEEEEEAEAETAKATP-RLASTNSSVL 113
G+ + ED + + +T V P SS +E+ A A P ++ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVK 253
Query: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
G LP + + K E ++ + G+ A T + + K+ K + A + T
Sbjct: 254 GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV---KASEKILQVRAASAPAKGT 310
Query: 174 EEEGSVPA--FGAAAKPGMVSAGQ----ADSSSEDTSSSSDETD-----VEGKPSVKPAQ 222
+G+ PA A A AG+ ++SSSE++S S +ET ++ K S K +Q
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 223 VKASSVSTKESPARKAAPAP-GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE 281
V A+S KESP + AAPAP GK G + + G K EE+S+SS E S+SEE
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG---------KREEDSQSSSEESDSEE 421
Query: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
EAPA Q K S K QVRAASAPAK +P KGA PAPP K G A+Q + GK EEDS S
Sbjct: 422 EAPA----QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
SSEES DS+ E AA Q K GK+ QV AS KGA P PPGK GPA A
Sbjct: 478 SSEES-DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Query: 402 QAGKREEDSQSSSEESDSEEE-------APAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
Q GK EEDS+SSSEES + APAQ K G Q + S+PAK
Sbjct: 537 QVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK---------G 587
Query: 455 PPRKTGPAAAQVQVGKQEEDSRSSSEESDS--DREALAAMNAAQVKPLGKSPQVKPASTM 512
PP+K GP A QV+ K ++S SS E SDS EA AAM AAQ KP K PQ K
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 513 GMGPLGKGAGPV-----PPGKVGPAT------PSAQVGKWEEDSESSSEESSDSSDGEVP 561
PV P K G AT P+ G +SSS E SDS + +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707
Query: 562 TAVAPAQEKSLGNILQAKPTSSPAKGP---------PQKAGPVAVQVKAEKPMDNSESSE 612
AV Q KS+G LQ K S P KG P K GP QVKAEK D SESSE
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED-SESSE 766
Query: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
E SDS ++ +PA + + K K A T SA V QA +++ +
Sbjct: 767 EESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826
Query: 673 TSPAGSSP------------------AVAGGTQR---PAEDSSSSEE-SDSEEEKTGLAV 710
P +P AVA Q P EDS SSEE SDSEEE A
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE----AE 882
Query: 711 TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD 770
T+ Q K GK Q++AA P K S +G AP PGKTGP+ Q A KQ+DS SS EESD
Sbjct: 883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQDDSGSSSEESD 940
Query: 771 SE---EAAASPAQVKTS----VKKTQAKANPAA--ARAPSAKGTISAPGKVVTAAAQAKQ 821
S+ AA + AQV V ++ A PAA A+A +A A TA + + +
Sbjct: 941 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000
Query: 822 RSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
V P + P T + P + P + + A + + +++
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 1060
Query: 880 EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEES 939
+ ++ P+ + Q + A RK P T + + +DS SS S
Sbjct: 1061 QVDSAVGTLPA-TSPQSTSVQAKGTNKLRKPKLPEVQQAT-KAPESSDDSEDSSDSSSGS 1118
Query: 940 DSDGEAPAAVTSA 952
+ DGE P SA
Sbjct: 1119 EEDGEGPQGAKSA 1131
Score = 265 bits (676), Expect = 2e-70
Identities = 294/977 (30%), Positives = 391/977 (40%), Gaps = 160/977 (16%)
Query: 63 RKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
RK AA + D S+SE S+ + EA A A + + V A
Sbjct: 457 RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP 516
Query: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG----- 177
A GK G + P GK + S + T V+ +E+
Sbjct: 517 LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 178 -----SVPAFGAAAKPG----MVSAGQADSSSEDTSSSSDETDVE----------GKPSV 218
S PA G K G V A + +SE + SSD D E KP++
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 219 KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA-------KKPEEESE 271
K Q KA T + + K AP +VG P+ G A PA + ++P E+S
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPV--RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694
Query: 272 SSEEG-SESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
SSEE SE E+ A T Q K+ K LQV+AAS P KG+ G+G P PGK G +Q
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390
KA K +EDSESS EES DSEE AA + Q K S K +Q A A A+ KG AP
Sbjct: 755 KAEK-QEDSESSEEES-DSEE---AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 391 --------------PGKTGPAV--------------------------AKAQAGKREEDS 410
P K P V A+AQ G EEDS
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP-EEDS 868
Query: 411 QSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV 468
SS EESDSEEEA AQ KPSGK Q+RAA APAKESPRKGAAP PP KTGP+AA Q
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QA 926
Query: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGP-VPPG 527
GKQ +DS SSSEESDSD EA AA+ +AQV +KP + + P AGP P
Sbjct: 927 GKQ-DDSGSSSEESDSDGEAPAAVTSAQV--------IKP-PLIFVDPNRSPAGPAATPA 976
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
+ A+ + E + SSS ES D + P ++ + A P +P
Sbjct: 977 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP--- 1033
Query: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSAD--SEEAPAAM--TAAQAKPALKIPQTKA 643
+ M + SS+ESS +D +E PA +A PA T
Sbjct: 1034 --------------KASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSV 1079
Query: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
K TN K+ V+ T+AP + + + SS S S E+ + +
Sbjct: 1080 QAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSS-------------SGSEEDGEGPQ 1126
Query: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV--KAEKQED 761
VG S + L + A+ + + + +L G P +T +A K
Sbjct: 1127 GAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP 1186
Query: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
S S AA K K QA A +P G +A G K
Sbjct: 1187 KLDSSPSVSSTLAAKDDPDGKQEAKPQQA----AGMLSPKTGGKEAASG-----TTPQKS 1237
Query: 822 RSPSKVKPPVRNPQNSTVLARGPAS---------------VPSVGKAVATAAQAQTGPEE 866
R P K NPQ ST+ + + SV K + + +
Sbjct: 1238 RKPKK---GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1294
Query: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA 926
D+ E L+ +P+ +T R+ + G A P KT ++
Sbjct: 1295 DTTKESSRKGWESRKRKLSGDQPAARTP--RSKKKKKLGAGEGGEASVSPEKTSTTSKGK 1352
Query: 927 GKQDDSGSSSEESDSDG 943
K+D + +E G
Sbjct: 1353 AKRDKASGDVKEKKGKG 1369
Score = 233 bits (594), Expect = 6e-61
Identities = 215/585 (36%), Positives = 268/585 (45%), Gaps = 111/585 (18%)
Query: 399 AKAQAGK-REEDSQSSSEESDSEEEAPAQA-----KPSGKAPQVRAASAPAKESPRKGAA 452
A QA K R D S+SE S+ EEEA A+ + + V A P+ + A
Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAE 128
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512
KTG + GK + S S + ++ + G P A+
Sbjct: 129 TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKP 188
Query: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572
GM G+ + S + SSD +D E +V PAQ K+
Sbjct: 189 GMVSAGQA----------------------DSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVK---------AEKPMDNSESSEESSDSADSEEA 623
+ P A P K G V QVK A+KP + SESSEE S+S EEA
Sbjct: 227 SVSTKESPARKAAPAPG-KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--EEEA 283
Query: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA 683
PA T +Q K + KI Q +A +A AK P + G +P G + AVA
Sbjct: 284 PAG-TRSQVKASEKILQVRAA------SAPAKGTPGK---------GATPAPPGKAGAVA 327
Query: 684 GGTQ--RPAEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTA 740
T+ +P EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G A
Sbjct: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 741 PVLPGKTGPTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
P PGKTGP V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKE 445
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
KG AP P K GPA AAQ
Sbjct: 446 SPRKGAAPAP--------------PRKT---------------GPA-----------AAQ 465
Query: 860 AQTGP-EEDSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Q G EEDS SS EESDS+ EA AQVKP GK+ Q++ A KGA P P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 916 PGKTGPS--AAQAGK-QDDSGSSSEES--DSDGEAPAAVTSAQDQ 955
PGK GP+ +AQ GK ++DS SSSEES SDGE P AV AQ++
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Score = 117 bits (294), Expect = 4e-26
Identities = 124/372 (33%), Positives = 165/372 (44%), Gaps = 89/372 (23%)
Query: 596 AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL---KIPQTKACPKKTNTTA 652
A + + P+ SESSEE + A++E A A A ++ +P + K T
Sbjct: 73 AKKTRVSDPISTSESSEEEEE-AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Query: 653 SAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
+ K G P A T + ++G + R + + S++ SE E+ G
Sbjct: 132 AGKT-----GNSMPHPATGKTV----ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
G AA+ P S GQ + ED+ SS +E+D E
Sbjct: 183 G------------AAAKPGMVSAGQADS-----------------SSEDTSSSSDETDVE 213
Query: 773 -EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV 831
+ + PAQVK S T K +PA AP APGKV Q K
Sbjct: 214 GKPSVKPAQVKASSVST--KESPARKAAP-------APGKVGDVTPQVK----------- 253
Query: 832 RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE--TLAQVKP 889
G A+ A +A+ PEE+S SSEE S+SEEEA T +QVK
Sbjct: 254 -------------------GGALPPAKRAKK-PEEESESSEEGSESEEEAPAGTRSQVKA 293
Query: 890 SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGK-QDDSGSSSEES-DSDGEA 945
S K Q+RAA APAK +P KGA P PPGK G A+Q AGK ++DS SSSEES DS+ E
Sbjct: 294 SEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 353
Query: 946 PAAVTSAQDQES 957
PAA Q + S
Sbjct: 354 PAAKALLQAKAS 365
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA-STNSSVLGADLPSSMKEKAK 126
+A +QA +V +E E+E + +T K + R + L D P++ ++K
Sbjct: 1271 EAQVQASVVKV-----LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK 1325
Query: 127 AETEK-AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+ + AG+ G + P T + GK+ R A V E + +GS+ + GA
Sbjct: 1326 KKKKLGAGEGGEASVSPEKTSTTSK---GKAKRDKASGD-----VKEKKGKGSLGSQGAK 1377
Query: 186 AKP--------GMVSAG-QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+P G V G Q++ S+ SD+ + + K + K +S ESP++
Sbjct: 1378 DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1437
Query: 237 KAAPAPGKVGDVT 249
K K + T
Sbjct: 1438 KKKKKKKKTAEQT 1450
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 1822 bits (4719), Expect = 0.0
Identities = 953/953 (100%), Positives = 953/953 (100%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV
Sbjct: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ
Sbjct: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Score = 410 bits (1053), Expect = e-114
Identities = 355/1015 (34%), Positives = 457/1015 (45%), Gaps = 161/1015 (15%)
Query: 60 GRKRKAEEDAALQAKKTRVSD-----PISTSESSEEEEEAEAETAKATP-RLASTNSSVL 113
G+ + ED + + +T V P SS +E+ A A P ++ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVK 253
Query: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
G LP + + K E ++ + G+ A T + + K+ K + A + T
Sbjct: 254 GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV---KASEKILQVRAASAPAKGT 310
Query: 174 EEEGSVPA--FGAAAKPGMVSAGQ----ADSSSEDTSSSSDETD-----VEGKPSVKPAQ 222
+G+ PA A A AG+ ++SSSE++S S +ET ++ K S K +Q
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 223 VKASSVSTKESPARKAAPAP-GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE 281
V A+S KESP + AAPAP GK G + + G K EE+S+SS E S+SEE
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG---------KREEDSQSSSEESDSEE 421
Query: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
EAPA Q K S K QVRAASAPAK +P KGA PAPP K G A+Q + GK EEDS S
Sbjct: 422 EAPA----QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
SSEES DS+ E AA Q K GK+ QV AS KGA P PPGK GPA A
Sbjct: 478 SSEES-DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Query: 402 QAGKREEDSQSSSEESDSEEE-------APAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
Q GK EEDS+SSSEES + APAQ K G Q + S+PAK
Sbjct: 537 QVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK---------G 587
Query: 455 PPRKTGPAAAQVQVGKQEEDSRSSSEESDS--DREALAAMNAAQVKPLGKSPQVKPASTM 512
PP+K GP A QV+ K ++S SS E SDS EA AAM AAQ KP K PQ K
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 513 GMGPLGKGAGPV-----PPGKVGPAT------PSAQVGKWEEDSESSSEESSDSSDGEVP 561
PV P K G AT P+ G +SSS E SDS + +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707
Query: 562 TAVAPAQEKSLGNILQAKPTSSPAKGP---------PQKAGPVAVQVKAEKPMDNSESSE 612
AV Q KS+G LQ K S P KG P K GP QVKAEK D SESSE
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED-SESSE 766
Query: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
E SDS ++ +PA + + K K A T SA V QA +++ +
Sbjct: 767 EESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826
Query: 673 TSPAGSSP------------------AVAGGTQR---PAEDSSSSEE-SDSEEEKTGLAV 710
P +P AVA Q P EDS SSEE SDSEEE A
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE----AE 882
Query: 711 TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD 770
T+ Q K GK Q++AA P K S +G AP PGKTGP+ Q A KQ+DS SS EESD
Sbjct: 883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQDDSGSSSEESD 940
Query: 771 SE-EA--------------------------AASPAQVKTSVKKTQAKANPAAARAPSAK 803
S+ EA AA+PAQ + + +A+A+ + AR+ S++
Sbjct: 941 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000
Query: 804 GTIS---------APG---KVVTA-------------AAQAKQRSPSKVKPPVRNPQNST 838
PG VVT A + + S++ + +T
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 1060
Query: 839 -VLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIR 897
V + PAS+P A+ AQ + + ++ S + TL P + Q
Sbjct: 1061 QVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQ-- 1118
Query: 898 AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 952
A RK P T + + +DS SS S+ DGE P SA
Sbjct: 1119 ---AKGTNKLRKPKLPEVQQAT-KAPESSDDSEDSSDSSSGSEEDGEGPQGAKSA 1169
Score = 266 bits (681), Expect = 5e-71
Identities = 303/1001 (30%), Positives = 402/1001 (40%), Gaps = 171/1001 (17%)
Query: 63 RKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
RK AA + D S+SE S+ + EA A A + + V A
Sbjct: 457 RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP 516
Query: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG----- 177
A GK G + P GK + S + T V+ +E+
Sbjct: 517 LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 178 -----SVPAFGAAAKPG----MVSAGQADSSSEDTSSSSDETDVE----------GKPSV 218
S PA G K G V A + +SE + SSD D E KP++
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 219 KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA-------KKPEEESE 271
K Q KA T + + K AP +VG P+ G A PA + ++P E+S
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPV--RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694
Query: 272 SSEEG-SESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
SSEE SE E+ A T Q K+ K LQV+AAS P KG+ G+G P PGK G +Q
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390
KA K +EDSESS EES DSEE AA + Q K S K +Q A A A+ KG AP
Sbjct: 755 KAEK-QEDSESSEEES-DSEE---AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 391 --------------PGKTGPAV--------------------------AKAQAGKREEDS 410
P K P V A+AQ G EEDS
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP-EEDS 868
Query: 411 QSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV 468
SS EESDSEEEA AQ KPSGK Q+RAA APAKESPRKGAAP PP KTGP+AA Q
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QA 926
Query: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGP-VPPG 527
GKQ +DS SSSEESDSD EA AA+ +AQV +KP + + P AGP P
Sbjct: 927 GKQ-DDSGSSSEESDSDGEAPAAVTSAQV--------IKP-PLIFVDPNRSPAGPAATPA 976
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
+ A+ + E + SSS ES D + P ++ + A P +P
Sbjct: 977 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP--- 1033
Query: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
+ M + SS+ESS +D ++ T K +P T+A K
Sbjct: 1034 --------------KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKV 1079
Query: 648 TNTTASAKVAPV---RVGTQAPRKAGT--ATSPAGSS--------------PAVAGGTQR 688
AS PV + + GT ATSP +S P V T+
Sbjct: 1080 LAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKA 1139
Query: 689 P--AEDSSSSEESDSEEEKTG-------LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739
P ++DS S +S S E+ G A T+G S + L + A+ + + +
Sbjct: 1140 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPS 1199
Query: 740 APVLPGKTGPTVTQV--KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAA 797
+L G P +T +A K S S AA K K QA A
Sbjct: 1200 QSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQA----AGM 1255
Query: 798 RAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS----------- 846
+P G +A G K R P K NPQ ST+ + +
Sbjct: 1256 LSPKTGGKEAASG-----TTPQKSRKPKK---GAGNPQASTLALQSNITQCLLGQPWPLN 1307
Query: 847 ----VPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
SV K + + + D+ E L+ +P+ +T R+
Sbjct: 1308 EAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTP--RSKKKK 1365
Query: 903 AKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 943
+ G A P KT ++ K+D + +E G
Sbjct: 1366 KLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKG 1406
Score = 233 bits (594), Expect = 6e-61
Identities = 215/585 (36%), Positives = 268/585 (45%), Gaps = 111/585 (18%)
Query: 399 AKAQAGK-REEDSQSSSEESDSEEEAPAQA-----KPSGKAPQVRAASAPAKESPRKGAA 452
A QA K R D S+SE S+ EEEA A+ + + V A P+ + A
Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAE 128
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512
KTG + GK + S S + ++ + G P A+
Sbjct: 129 TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKP 188
Query: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572
GM G+ + S + SSD +D E +V PAQ K+
Sbjct: 189 GMVSAGQA----------------------DSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVK---------AEKPMDNSESSEESSDSADSEEA 623
+ P A P K G V QVK A+KP + SESSEE S+S EEA
Sbjct: 227 SVSTKESPARKAAPAPG-KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--EEEA 283
Query: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA 683
PA T +Q K + KI Q +A +A AK P + G +P G + AVA
Sbjct: 284 PAG-TRSQVKASEKILQVRAA------SAPAKGTPGK---------GATPAPPGKAGAVA 327
Query: 684 GGTQ--RPAEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTA 740
T+ +P EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G A
Sbjct: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 741 PVLPGKTGPTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
P PGKTGP V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKE 445
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
KG AP P K GPA AAQ
Sbjct: 446 SPRKGAAPAP--------------PRKT---------------GPA-----------AAQ 465
Query: 860 AQTGP-EEDSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Q G EEDS SS EESDS+ EA AQVKP GK+ Q++ A KGA P P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 916 PGKTGPS--AAQAGK-QDDSGSSSEES--DSDGEAPAAVTSAQDQ 955
PGK GP+ +AQ GK ++DS SSSEES SDGE P AV AQ++
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Score = 117 bits (294), Expect = 4e-26
Identities = 124/372 (33%), Positives = 165/372 (44%), Gaps = 89/372 (23%)
Query: 596 AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL---KIPQTKACPKKTNTTA 652
A + + P+ SESSEE + A++E A A A ++ +P + K T
Sbjct: 73 AKKTRVSDPISTSESSEEEEE-AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Query: 653 SAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
+ K G P A T + ++G + R + + S++ SE E+ G
Sbjct: 132 AGKT-----GNSMPHPATGKTV----ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
G AA+ P S GQ + ED+ SS +E+D E
Sbjct: 183 G------------AAAKPGMVSAGQADS-----------------SSEDTSSSSDETDVE 213
Query: 773 -EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV 831
+ + PAQVK S T K +PA AP APGKV Q K
Sbjct: 214 GKPSVKPAQVKASSVST--KESPARKAAP-------APGKVGDVTPQVK----------- 253
Query: 832 RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE--TLAQVKP 889
G A+ A +A+ PEE+S SSEE S+SEEEA T +QVK
Sbjct: 254 -------------------GGALPPAKRAKK-PEEESESSEEGSESEEEAPAGTRSQVKA 293
Query: 890 SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGK-QDDSGSSSEES-DSDGEA 945
S K Q+RAA APAK +P KGA P PPGK G A+Q AGK ++DS SSSEES DS+ E
Sbjct: 294 SEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 353
Query: 946 PAAVTSAQDQES 957
PAA Q + S
Sbjct: 354 PAAKALLQAKAS 365
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA-STNSSVLGADLPSSMKEKAK 126
+A +QA +V +E E+E + +T K + R + L D P++ ++K
Sbjct: 1308 EAQVQASVVKV-----LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK 1362
Query: 127 AETEK-AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+ + AG+ G + P T + GK+ R A V E + +GS+ + GA
Sbjct: 1363 KKKKLGAGEGGEASVSPEKTSTTSK---GKAKRDKASGD-----VKEKKGKGSLGSQGAK 1414
Query: 186 AKP--------GMVSAG-QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+P G V G Q++ S+ SD+ + + K + K +S ESP++
Sbjct: 1415 DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1474
Query: 237 KAAPAPGKVGDVT 249
K K + T
Sbjct: 1475 KKKKKKKKTAEQT 1487
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 1822 bits (4719), Expect = 0.0
Identities = 953/953 (100%), Positives = 953/953 (100%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP
Sbjct: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV
Sbjct: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ
Sbjct: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Score = 413 bits (1062), Expect = e-115
Identities = 347/973 (35%), Positives = 448/973 (46%), Gaps = 115/973 (11%)
Query: 60 GRKRKAEEDAALQAKKTRVSD-----PISTSESSEEEEEAEAETAKATP-RLASTNSSVL 113
G+ + ED + + +T V P SS +E+ A A P ++ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVK 253
Query: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
G LP + + K E ++ + G+ A T + + K+ K + A + T
Sbjct: 254 GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV---KASEKILQVRAASAPAKGT 310
Query: 174 EEEGSVPA--FGAAAKPGMVSAGQ----ADSSSEDTSSSSDETD-----VEGKPSVKPAQ 222
+G+ PA A A AG+ ++SSSE++S S +ET ++ K S K +Q
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 223 VKASSVSTKESPARKAAPAP-GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE 281
V A+S KESP + AAPAP GK G + + G K EE+S+SS E S+SEE
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG---------KREEDSQSSSEESDSEE 421
Query: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSES 341
EAPA Q K S K QVRAASAPAK +P KGA PAPP K G A+Q + GK EEDS S
Sbjct: 422 EAPA----QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 342 SSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
SSEES DS+ E AA Q K GK+ QV AS KGA P PPGK GPA A
Sbjct: 478 SSEES-DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Query: 402 QAGKREEDSQSSSEESDSEEE-------APAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
Q GK EEDS+SSSEES + APAQ K G Q + S+PAK
Sbjct: 537 QVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK---------G 587
Query: 455 PPRKTGPAAAQVQVGKQEEDSRSSSEESDS--DREALAAMNAAQVKPLGKSPQVKPASTM 512
PP+K GP A QV+ K ++S SS E SDS EA AAM AAQ KP K PQ K
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 513 GMGPLGKGAGPV-----PPGKVGPAT------PSAQVGKWEEDSESSSEESSDSSDGEVP 561
PV P K G AT P+ G +SSS E SDS + +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707
Query: 562 TAVAPAQEKSLGNILQAKPTSSPAKGP---------PQKAGPVAVQVKAEKPMDNSESSE 612
AV Q KS+G LQ K S P KG P K GP QVKAEK D SESSE
Sbjct: 708 LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED-SESSE 766
Query: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
E SDS ++ +PA + + K K A T SA V QA +++ +
Sbjct: 767 EESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSK 826
Query: 673 TSPAGSSP------------------AVAGGTQR---PAEDSSSSEE-SDSEEEKTGLAV 710
P +P AVA Q P EDS SSEE SDSEEE A
Sbjct: 827 VKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEE----AE 882
Query: 711 TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD 770
T+ Q K GK Q++AA P K S +G AP PGKTGP+ Q A KQ+DS SS EESD
Sbjct: 883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGKQDDSGSSSEESD 940
Query: 771 SE---EAAASPAQVKTS----VKKTQAKANPAA--ARAPSAKGTISAPGKVVTAAAQAKQ 821
S+ AA + AQV V ++ A PAA A+A +A A TA + + +
Sbjct: 941 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000
Query: 822 RSPSKVKPPVR--NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
V P + P T + P + P + + A + + +++
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 1060
Query: 880 EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEES 939
+ ++ P+ + Q + A RK P T + + +DS SS S
Sbjct: 1061 QVDSAVGTLPA-TSPQSTSVQAKGTNKLRKPKLPEVQQAT-KAPESSDDSEDSSDSSSGS 1118
Query: 940 DSDGEAPAAVTSA 952
+ DGE P SA
Sbjct: 1119 EEDGEGPQGAKSA 1131
Score = 265 bits (678), Expect = 1e-70
Identities = 295/977 (30%), Positives = 393/977 (40%), Gaps = 161/977 (16%)
Query: 63 RKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
RK AA + D S+SE S+ + EA A A + + V A
Sbjct: 457 RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP 516
Query: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG----- 177
A GK G + P GK + S + T V+ +E+
Sbjct: 517 LGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNIL 576
Query: 178 -----SVPAFGAAAKPG----MVSAGQADSSSEDTSSSSDETDVE----------GKPSV 218
S PA G K G V A + +SE + SSD D E KP++
Sbjct: 577 QAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL 636
Query: 219 KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA-------KKPEEESE 271
K Q KA T + + K AP +VG P+ G A PA + ++P E+S
Sbjct: 637 KIPQTKACPKKTNTTASAKVAPV--RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694
Query: 272 SSEEG-SESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
SSEE SE E+ A T Q K+ K LQV+AAS P KG+ G+G P PGK G +Q
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 754
Query: 331 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 390
KA K +EDSESS EES DSEE AA + Q K S K +Q A A A+ KG AP
Sbjct: 755 KAEK-QEDSESSEEES-DSEE---AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAP 809
Query: 391 --------------PGKTGPAV--------------------------AKAQAGKREEDS 410
P K P V A+AQ G EEDS
Sbjct: 810 GKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP-EEDS 868
Query: 411 QSSSEESDSEEEAP--AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV 468
SS EESDSEEEA AQ KPSGK Q+RAA APAKESPRKGAAP PP KTGP+AA Q
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA--QA 926
Query: 469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGP-VPPG 527
GKQ +DS SSSEESDSD EA AA+ +AQV +KP + + P AGP P
Sbjct: 927 GKQ-DDSGSSSEESDSDGEAPAAVTSAQV--------IKP-PLIFVDPNRSPAGPAATPA 976
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
+ A+ + E + SSS ES D + P ++ + A P +P
Sbjct: 977 QAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP--- 1033
Query: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSAD--SEEAPAAM--TAAQAKPALKIPQTKA 643
+ M + SS+ESS +D +E PA +A PA T
Sbjct: 1034 --------------KASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSV 1079
Query: 644 CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
K TN K+ V+ T+AP + ++ ++ SS SEE
Sbjct: 1080 QAKGTNKLRKPKLPEVQQATKAPES--------------SDDSEDSSDSSSGSEEDGEGP 1125
Query: 704 EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV--KAEKQED 761
+ A T+G S + L + A+ + + + +L G P +T +A K
Sbjct: 1126 QGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATP 1185
Query: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
S S AA K K QA A +P G +A G K
Sbjct: 1186 KLDSSPSVSSTLAAKDDPDGKQEAKPQQA----AGMLSPKTGGKEAASG-----TTPQKS 1236
Query: 822 RSPSKVKPPVRNPQNSTVLARGPAS---------------VPSVGKAVATAAQAQTGPEE 866
R P K NPQ ST+ + + SV K + + +
Sbjct: 1237 RKPKK---GAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1293
Query: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA 926
D+ E L+ +P+ +T R+ + G A P KT ++
Sbjct: 1294 DTTKESSRKGWESRKRKLSGDQPAARTP--RSKKKKKLGAGEGGEASVSPEKTSTTSKGK 1351
Query: 927 GKQDDSGSSSEESDSDG 943
K+D + +E G
Sbjct: 1352 AKRDKASGDVKEKKGKG 1368
Score = 233 bits (594), Expect = 6e-61
Identities = 215/585 (36%), Positives = 268/585 (45%), Gaps = 111/585 (18%)
Query: 399 AKAQAGK-REEDSQSSSEESDSEEEAPAQA-----KPSGKAPQVRAASAPAKESPRKGAA 452
A QA K R D S+SE S+ EEEA A+ + + V A P+ + A
Sbjct: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAE 128
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512
KTG + GK + S S + ++ + G P A+
Sbjct: 129 TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKP 188
Query: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572
GM G+ + S + SSD +D E +V PAQ K+
Sbjct: 189 GMVSAGQA----------------------DSSSEDTSSSSDETDVEGKPSVKPAQVKAS 226
Query: 573 GNILQAKPTSSPAKGPPQKAGPVAVQVK---------AEKPMDNSESSEESSDSADSEEA 623
+ P A P K G V QVK A+KP + SESSEE S+S EEA
Sbjct: 227 SVSTKESPARKAAPAPG-KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES--EEEA 283
Query: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA 683
PA T +Q K + KI Q +A +A AK P + G +P G + AVA
Sbjct: 284 PAG-TRSQVKASEKILQVRAA------SAPAKGTPGK---------GATPAPPGKAGAVA 327
Query: 684 GGTQ--RPAEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTA 740
T+ +P EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G A
Sbjct: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 741 PVLPGKTGPTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
P PGKTGP V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKE 445
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
KG AP P K GPA AAQ
Sbjct: 446 SPRKGAAPAP--------------PRKT---------------GPA-----------AAQ 465
Query: 860 AQTGP-EEDSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Q G EEDS SS EESDS+ EA AQVKP GK+ Q++ A KGA P P
Sbjct: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
Query: 916 PGKTGPS--AAQAGK-QDDSGSSSEES--DSDGEAPAAVTSAQDQ 955
PGK GP+ +AQ GK ++DS SSSEES SDGE P AV AQ++
Sbjct: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
Score = 117 bits (294), Expect = 4e-26
Identities = 124/372 (33%), Positives = 165/372 (44%), Gaps = 89/372 (23%)
Query: 596 AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL---KIPQTKACPKKTNTTA 652
A + + P+ SESSEE + A++E A A A ++ +P + K T
Sbjct: 73 AKKTRVSDPISTSESSEEEEE-AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Query: 653 SAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
+ K G P A T + ++G + R + + S++ SE E+ G
Sbjct: 132 AGKT-----GNSMPHPATGKTV----ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
G AA+ P S GQ + ED+ SS +E+D E
Sbjct: 183 G------------AAAKPGMVSAGQADS-----------------SSEDTSSSSDETDVE 213
Query: 773 -EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV 831
+ + PAQVK S T K +PA AP APGKV Q K
Sbjct: 214 GKPSVKPAQVKASSVST--KESPARKAAP-------APGKVGDVTPQVK----------- 253
Query: 832 RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE--TLAQVKP 889
G A+ A +A+ PEE+S SSEE S+SEEEA T +QVK
Sbjct: 254 -------------------GGALPPAKRAKK-PEEESESSEEGSESEEEAPAGTRSQVKA 293
Query: 890 SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGK-QDDSGSSSEES-DSDGEA 945
S K Q+RAA APAK +P KGA P PPGK G A+Q AGK ++DS SSSEES DS+ E
Sbjct: 294 SEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 353
Query: 946 PAAVTSAQDQES 957
PAA Q + S
Sbjct: 354 PAAKALLQAKAS 365
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA-STNSSVLGADLPSSMKEKAK 126
+A +QA +V +E E+E + +T K + R + L D P++ ++K
Sbjct: 1270 EAQVQASVVKV-----LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK 1324
Query: 127 AETEK-AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+ + AG+ G + P T + GK+ R A V E + +GS+ + GA
Sbjct: 1325 KKKKLGAGEGGEASVSPEKTSTTSK---GKAKRDKASGD-----VKEKKGKGSLGSQGAK 1376
Query: 186 AKP--------GMVSAG-QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+P G V G Q++ S+ SD+ + + K + K +S ESP++
Sbjct: 1377 DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1436
Query: 237 KAAPAPGKVGDVT 249
K K + T
Sbjct: 1437 KKKKKKKKTAEQT 1449
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 1441 bits (3729), Expect = 0.0
Identities = 788/953 (82%), Positives = 810/953 (84%), Gaps = 77/953 (8%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEE
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEE----------------------------- 91
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
E+A+AET KA P T +++L P E + +ETE+ G
Sbjct: 92 --EEAEAETAKAT--------PRLASTNSSVLGADLPSSMKEKAK-----AETEKAGKT- 135
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
+S + + + GK K A+ A++ E+ + P
Sbjct: 136 ---------------GNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
A G K G + + E+ S SS+E T +VKASEKILQV
Sbjct: 181 AFGAAA------KPGMVSAGQADSSSEDTSSSSDE-----------TDVEVKASEKILQV 223
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 224 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 283
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 284 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 343
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 344 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 403
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 404 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 463
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 464 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 523
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 524 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 704 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 823
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ
Sbjct: 824 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 876
Score = 268 bits (685), Expect = 2e-71
Identities = 302/993 (30%), Positives = 402/993 (40%), Gaps = 194/993 (19%)
Query: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
+A K S+ ESS+ EEE A A + + S V A P+ + A
Sbjct: 254 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP 313
Query: 132 AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMV 191
GKTG PA K A S S E + ++ + G P AA+ P
Sbjct: 314 PGKTG-----PAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 368
Query: 192 SAG------------------QADSSSEDTSSSSDETD-----------VEGKPSVKPAQ 222
S Q ED+ SSS+E+D + KP K Q
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 223 VKASSVSTKESPARKAAPAP-GKVGDVTPQVKGG-----------------------ALP 258
VK +S + A P P GKVG TP + G A+
Sbjct: 429 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 488
Query: 259 PAK-------------------------------RAKKPEEESESSEEGSES--EEEAPA 285
PA+ +A+KP + SESSEE S+S EEAPA
Sbjct: 489 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 548
Query: 286 G-TRSQVKASEKILQVRAA------SAPAKGTPGK---------GATPAPPGKAGAVASQ 329
T +Q K + KI Q +A +A AK P + G +P G + AVA
Sbjct: 549 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 608
Query: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
T+ +P EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G AP
Sbjct: 609 TQ--RPAEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 665
Query: 390 PPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKESP 447
PGKTGP V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+
Sbjct: 666 LPGKTGPTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 724
Query: 448 RKGAAPAP--------------PRKT---------------GPA-----------AAQVQ 467
KG AP P K GPA AAQ Q
Sbjct: 725 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 784
Query: 468 VGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
G EEDS SS EESDS+ EA AQVKP GK+ Q++ A KGA P PPG
Sbjct: 785 TGP-EEDSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPG 840
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
K GP+ +AQ GK ++DS SSSEES SDGE P AV AQ ++ P SPA G
Sbjct: 841 KTGPS--AAQAGK-QDDSGSSSEESD--SDGEAPAAVTSAQVIK-PPLIFVDPNRSPA-G 893
Query: 588 P---PQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT--K 642
P P +A + KA + SS S+ D A +T + +P +
Sbjct: 894 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPR 953
Query: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED-SSSSEESDS 701
PK + AS+ R+ + ++ G AT + +PA TQ + + + E+
Sbjct: 954 IAPKASMAGASSSKESSRI-SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
+T + V A ++ SV KG+ + P LP Q + E
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGT-NKLRKPKLPE------VQQATKAPES 1065
Query: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
S+ SE+ SDS + + K P +R + +A A + Q
Sbjct: 1066 SDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPS-Q 1124
Query: 822 RSPSKVKPPVRNPQNSTVLARGPA--SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
S P P NS P S PSV +A +D ++E+ ++
Sbjct: 1125 SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA---------KDDPDGKQEAKPQQ 1175
Query: 880 EAETLAQVKPSGKTHQIRAALAPAK-ESPRKGA 911
A L+ K GK + + P K P+KGA
Sbjct: 1176 AAGMLSP-KTGGK--EAASGTTPQKSRKPKKGA 1205
Score = 197 bits (501), Expect = 4e-50
Identities = 174/457 (38%), Positives = 222/457 (48%), Gaps = 88/457 (19%)
Query: 544 DSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSS---PAKGPPQKAGP----- 594
D S+SE S + + E TA A P + ++L A SS AK +KAG
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 595 --------VAVQVKAEKPMDNSESSEESSDSADSEEA-----------PAAMTAAQAKPA 635
VA + + P ++E S ++ +++EE P ++A QA +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA----GTATSPAGSSPAVAGGTQ--RP 689
+ + + AS K+ VR + AP K G +P G + AVA T+ +P
Sbjct: 200 SEDTSSSSDETDVEVKASEKILQVRAAS-APAKGTPGKGATPAPPGKAGAVASQTKAGKP 258
Query: 690 AEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G AP PGKTG
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG 318
Query: 749 PTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
P V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+ KG
Sbjct: 319 PAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKESPRKGAAP 376
Query: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP-EE 866
AP P K GPA AAQ Q G EE
Sbjct: 377 AP--------------PRKT---------------GPA-----------AAQVQVGKQEE 396
Query: 867 DSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS- 922
DS SS EESDS+ EA AQVKP GK+ Q++ A KGA P PPGK GP+
Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 456
Query: 923 -AAQAGK-QDDSGSSSEES--DSDGEAPAAVTSAQDQ 955
+AQ GK ++DS SSSEES SDGE P AV AQ++
Sbjct: 457 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 493
Score = 94.4 bits (233), Expect = 5e-19
Identities = 80/215 (37%), Positives = 109/215 (50%), Gaps = 30/215 (13%)
Query: 761 DSESSEEESDSEEAAASP--AQVKTSV------KKTQAKANPAAARAPSAKGTISAPGKV 812
+S EEE+++E A A+P A +SV + KA +A ++ P
Sbjct: 86 ESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATG 145
Query: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP--ASVPSVGKA----VATAAQAQTGPEE 866
T A +SP K P N+T+++ SVP+ G A + +A QA + E+
Sbjct: 146 KTVANLLSGKSPRKSAEP---SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ- 925
S SS+E T +VK S K Q+RAA APAK +P KGA P PPGK G A+Q
Sbjct: 203 TSSSSDE---------TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 253
Query: 926 -AGK-QDDSGSSSEES-DSDGEAPAAVTSAQDQES 957
AGK ++DS SSSEES DS+ E PAA Q + S
Sbjct: 254 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 288
Score = 68.2 bits (165), Expect = 4e-11
Identities = 153/750 (20%), Positives = 257/750 (34%), Gaps = 175/750 (23%)
Query: 45 TLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKAT-- 102
T+ + Q+ SE + E+AA A +V + +++ A A +AK T
Sbjct: 673 TVTQVKAEKQEDSESSEEESDSEEAA--ASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 730
Query: 103 ----------------------PRLASTNSSVLG---ADLPS---SMKEKAKAETEKAGK 134
P NS+VL A +PS ++ A+A+T
Sbjct: 731 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEED 790
Query: 135 TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAG 194
+G+S + + L K K+ + A E+ +G+ P P AG
Sbjct: 791 SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAG 850
Query: 195 QADSSSEDTSSSSDETDVEGK--------------------------PSVKPAQVKASSV 228
+ D D+ SSS+E+D +G+ P+ PAQ +A+S
Sbjct: 851 KQD----DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAAST 906
Query: 229 STK----ESPARKAA---------PA-----PG-KVGDVTPQVKGGALPPAKRAKKPEEE 269
K ES AR ++ PA PG + VT + P
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSS 966
Query: 270 SESSEEGSESEEEAPAGTRSQ--------VKASEKILQVRAASA--------PAKGTPG- 312
ESS ++E PA S+ +A+ K+L +A+ A P+ G
Sbjct: 967 KESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSA 1026
Query: 313 ----------------KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEE---- 352
KG K V TKA + +DSE SS+ SS SEE+
Sbjct: 1027 VGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP 1086
Query: 353 ------------TPAAKALLQAKASGKTSQ---VGAASAPAKESPRKGAAPAPPGKTGPA 397
TP+ L + + ++S+ V + + G PA + A
Sbjct: 1087 QGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA-NSQASKA 1145
Query: 398 VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP---- 453
K + + ++ ++ D ++EA Q +P+ A + +P+K P
Sbjct: 1146 TPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGA 1205
Query: 454 -------------------APPRKTGPAAAQVQVGK------QEEDSRSSSEESDSDREA 488
P A Q V K ++E + +S R+
Sbjct: 1206 GNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKG 1265
Query: 489 LAA--MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSE 546
+ + +P ++P+ K +G G G+ + V P K +T S K ++ S
Sbjct: 1266 WESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEAS--VSPEKT--STTSKGKAKRDKASG 1321
Query: 547 SSSEESSDSSDGEVPTAVAPAQE--KSLGNIL---QAKPTSSPAKGPPQKAGPVAVQVKA 601
E+ S G P +E K +G + Q+ P S K K + K
Sbjct: 1322 DVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR-KKDKEKKE 1380
Query: 602 EKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
+K S+++S + ++ TA Q
Sbjct: 1381 KKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1410
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA-STNSSVLGADLPSSMKEKAK 126
+A +QA +V +E E+E + +T K + R + L D P++ ++K
Sbjct: 1232 EAQVQASVVKV-----LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK 1286
Query: 127 AETEK-AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+ + AG+ G + P T + GK+ R A V E + +GS+ + GA
Sbjct: 1287 KKKKLGAGEGGEASVSPEKTSTTSK---GKAKRDKASGD-----VKEKKGKGSLGSQGAK 1338
Query: 186 AKP--------GMVSAG-QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+P G V G Q++ S+ SD+ + + K + K +S ESP++
Sbjct: 1339 DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1398
Query: 237 KAAPAPGKVGDVT 249
K K + T
Sbjct: 1399 KKKKKKKKTAEQT 1411
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 1441 bits (3729), Expect = 0.0
Identities = 788/953 (82%), Positives = 810/953 (84%), Gaps = 77/953 (8%)
Query: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG
Sbjct: 1 MAEARKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELG 60
Query: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
RKRKAEEDAALQAKKTRVSDPISTSESSEEE
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEE----------------------------- 91
Query: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
E+A+AET KA P T +++L P E + +ETE+ G
Sbjct: 92 --EEAEAETAKAT--------PRLASTNSSVLGADLPSSMKEKAK-----AETEKAGKT- 135
Query: 181 AFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP 240
+S + + + GK K A+ A++ E+ + P
Sbjct: 136 ---------------GNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 241 APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
A G K G + + E+ S SS+E T +VKASEKILQV
Sbjct: 181 AFGAAA------KPGMVSAGQADSSSEDTSSSSDE-----------TDVEVKASEKILQV 223
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 360
RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL
Sbjct: 224 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALL 283
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE
Sbjct: 284 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSE 343
Query: 421 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 480
EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE
Sbjct: 344 EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSE 403
Query: 481 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 540
ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK
Sbjct: 404 ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGK 463
Query: 541 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK
Sbjct: 464 WEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 523
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR
Sbjct: 524 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 583
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK
Sbjct: 584 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ
Sbjct: 644 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 703
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL
Sbjct: 704 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 763
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL
Sbjct: 764 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 823
Query: 901 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ
Sbjct: 824 APAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 876
Score = 197 bits (501), Expect = 4e-50
Identities = 174/457 (38%), Positives = 222/457 (48%), Gaps = 88/457 (19%)
Query: 544 DSESSSEESSDSSDGEVPTAVA-PAQEKSLGNILQAKPTSS---PAKGPPQKAGP----- 594
D S+SE S + + E TA A P + ++L A SS AK +KAG
Sbjct: 80 DPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSM 139
Query: 595 --------VAVQVKAEKPMDNSESSEESSDSADSEEA-----------PAAMTAAQAKPA 635
VA + + P ++E S ++ +++EE P ++A QA +
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 636 LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA----GTATSPAGSSPAVAGGTQ--RP 689
+ + + AS K+ VR + AP K G +P G + AVA T+ +P
Sbjct: 200 SEDTSSSSDETDVEVKASEKILQVRAAS-APAKGTPGKGATPAPPGKAGAVASQTKAGKP 258
Query: 690 AEDS-SSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
EDS SSSEES EE+T A + QAK+ GK QV AAS P K S +G AP PGKTG
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG 318
Query: 749 PTVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
P V + +A K +EDS+SS EESDSEE A PAQ K S K Q +A A A+ KG
Sbjct: 319 PAVAKAQAGKREEDSQSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKESPRKGAAP 376
Query: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP-EE 866
AP P K GPA AAQ Q G EE
Sbjct: 377 AP--------------PRKT---------------GPA-----------AAQVQVGKQEE 396
Query: 867 DSGSSEEESDSEEEA---ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS- 922
DS SS EESDS+ EA AQVKP GK+ Q++ A KGA P PPGK GP+
Sbjct: 397 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 456
Query: 923 -AAQAGK-QDDSGSSSEES--DSDGEAPAAVTSAQDQ 955
+AQ GK ++DS SSSEES SDGE P AV AQ++
Sbjct: 457 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 493
Score = 152 bits (383), Expect = 2e-36
Identities = 229/932 (24%), Positives = 360/932 (38%), Gaps = 159/932 (17%)
Query: 73 AKKTRVSDPISTSESSEEEEE-AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
A + + P+ SESSEE + A++E A A A ++ +P + K T
Sbjct: 519 AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL---KIPQTKACPKKTNTTA 575
Query: 132 AGKT-----GNSMPHPATGKTV----ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
+ K G P A T + ++G + R + + S++ SE E+ G
Sbjct: 576 SAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
Query: 183 G------------AAAKPGMVSAGQADS-----------------SSEDTSSSSDETDVE 213
G AA+ P S GQ + ED+ SS +E+D E
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695
Query: 214 GKPSVKPAQVKASSVST--KESPARKAAP-------APGKVGDVTPQVK----------- 253
+ + PAQVK S T K +PA AP APGKV Q K
Sbjct: 696 -EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV 754
Query: 254 -------------------GGALPPAKRAKK-PEEESESSEEGSESEEEAPAGTRSQVKA 293
G A+ A +A+ PEE+S SSEE S+SEEEA T +QVK
Sbjct: 755 RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE--TLAQVKP 812
Query: 294 SEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 353
S K Q+RAA APAK +P KGA P PPGK G A+Q AGK ++S S EE+
Sbjct: 813 SGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ--AGK--------QDDSGSSSEES 862
Query: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP-APPGKTGPAVAKAQAGKREEDSQS 412
+ +A A+ ++QV + R A P A P + A +A E ++S
Sbjct: 863 DSDG---EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARS 919
Query: 413 SSEESDSEEEAPAQ--AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
SS ES+ E+ PA P + V +A + +P+ A A K ++++ GK
Sbjct: 920 SSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK---ESSRISDGK 976
Query: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP--ASTMGMGPLGKGAGPVP--- 525
++E +++ S + +L AA K+ + +P A T + G +P
Sbjct: 977 KQEG--PATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATS 1034
Query: 526 PGKVG-----------PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN 574
P P P Q +S SE+SSDSS G P KS
Sbjct: 1035 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1094
Query: 575 ILQAKPTSSPAKGP-PQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 633
+ GP P + + + AE D+ + S S S +T A ++
Sbjct: 1095 L-----------GPTPSRTETLVEETAAESSEDDVVA---PSQSLLSGYMTPGLTPANSQ 1140
Query: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT-----QR 688
+ P+ + P ++T A AK P P++A SP A GT ++
Sbjct: 1141 ASKATPKLDSSPSVSSTLA-AKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRK 1199
Query: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
P + + + + S + +GQ + + QV+A+ V V L L +
Sbjct: 1200 PKKGAGNPQASTLALQSNITQCLLGQPWPLNEA-QVQASVVKVLTEL-------LEQERK 1251
Query: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
V K ++ ES + + ++ AA + K K + A+ T
Sbjct: 1252 KVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKG 1311
Query: 809 PGKVVTAAAQAKQR--------SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQA 860
K A+ K++ +K +P + + G S P K + +
Sbjct: 1312 KAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1371
Query: 861 QTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 892
+ E+ + + S +++E+ +Q K K
Sbjct: 1372 KKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1403
Score = 94.4 bits (233), Expect = 5e-19
Identities = 80/215 (37%), Positives = 109/215 (50%), Gaps = 30/215 (13%)
Query: 761 DSESSEEESDSEEAAASP--AQVKTSV------KKTQAKANPAAARAPSAKGTISAPGKV 812
+S EEE+++E A A+P A +SV + KA +A ++ P
Sbjct: 86 ESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATG 145
Query: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP--ASVPSVGKA----VATAAQAQTGPEE 866
T A +SP K P N+T+++ SVP+ G A + +A QA + E+
Sbjct: 146 KTVANLLSGKSPRKSAEP---SANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ- 925
S SS+E T +VK S K Q+RAA APAK +P KGA P PPGK G A+Q
Sbjct: 203 TSSSSDE---------TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 253
Query: 926 -AGK-QDDSGSSSEES-DSDGEAPAAVTSAQDQES 957
AGK ++DS SSSEES DS+ E PAA Q + S
Sbjct: 254 KAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 288
Score = 50.4 bits (119), Expect = 8e-06
Identities = 100/448 (22%), Positives = 170/448 (37%), Gaps = 59/448 (13%)
Query: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSES---SEEEEEAEAETAKATPRLASTNS 110
+++S + +K E A +KK S P++ + +++ EA+ A+ P + +S
Sbjct: 967 KESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS-SGVDS 1025
Query: 111 SV--LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
+V L A P S +AK T K K AT K+P S + ++
Sbjct: 1026 AVGTLPATSPQSTSVQAKG-TNKLRKPKLPEVQQAT----------KAPESSDDSEDSSD 1074
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
S +EE+G P +A + + ++ E+T++ S E DV + +
Sbjct: 1075 SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1134
Query: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE--SSEEGSESEEEAPAG 286
+ S A KA P V+ + P K+ KP++ + S + G +EA +G
Sbjct: 1135 TPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG---KEAASG 1191
Query: 287 TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES 346
T Q K G G A + +Q G+P +E+ + S
Sbjct: 1192 TTPQKSRKPK--------------KGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQAS 1237
Query: 347 SDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG--PAVAKAQAG 404
K L + + V KES RKG +G PA ++
Sbjct: 1238 --------VVKVLTELLEQERKKVVDT----TKESSRKGWESRKRKLSGDQPAARTPRSK 1285
Query: 405 KREE-DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGP-- 461
K+++ + E S S E+ +K GKA + + AS KE KG+ + K P
Sbjct: 1286 KKKKLGAGEGGEASVSPEKTSTTSK--GKAKRDK-ASGDVKEKKGKGSLGSQGAKDEPEE 1342
Query: 462 ---AAAQVQVGKQEEDSRSSSEESDSDR 486
G + + +S E+ SD+
Sbjct: 1343 ELQKGMGTVEGGDQSNPKSKKEKKKSDK 1370
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/193 (23%), Positives = 81/193 (41%), Gaps = 24/193 (12%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA-STNSSVLGADLPSSMKEKAK 126
+A +QA +V +E E+E + +T K + R + L D P++ ++K
Sbjct: 1231 EAQVQASVVKV-----LTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSK 1285
Query: 127 AETEK-AGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+ + AG+ G + P T + GK+ R A V E + +GS+ + GA
Sbjct: 1286 KKKKLGAGEGGEASVSPEKTSTTSK---GKAKRDKASGD-----VKEKKGKGSLGSQGAK 1337
Query: 186 AKP--------GMVSAG-QADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+P G V G Q++ S+ SD+ + + K + K +S ESP++
Sbjct: 1338 DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1397
Query: 237 KAAPAPGKVGDVT 249
K K + T
Sbjct: 1398 KKKKKKKKTAEQT 1410
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 149 bits (375), Expect = 2e-35
Identities = 209/798 (26%), Positives = 297/798 (37%), Gaps = 169/798 (21%)
Query: 1 MAEARKRR----ELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQT 56
MA+A RR +L PL+ L A + + +G A +LLDIY+ W ++
Sbjct: 1 MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKS 60
Query: 57 SEL-GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
+++ RK +A A +AKK S + +SSEEEEE + AK
Sbjct: 61 AKVPERKLQANGPVAKKAKKKASSS--DSEDSSEEEEEVQGPPAK--------------- 103
Query: 116 DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
KA ++ G +P GK A S +S++ + +
Sbjct: 104 --------KAAVPAKRVG-----LP---PGKAAAKASESSSSEESSDDDDEEDQKKQPVQ 147
Query: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPA 235
+G P AA P A +DS S+ SSS DE KP + P VKA +
Sbjct: 148 KGVKPQAKAAKAPPK-KAKSSDSDSD--SSSEDEPPKNQKPKITPVTVKAQT-------- 196
Query: 236 RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASE 295
KA P P + P++ G +A S SS +SEEE
Sbjct: 197 -KAPPKPAR---AAPKIANG------KAASSSSSSSSSSSSDDSEEE------------- 233
Query: 296 KILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
+AA+ P K P K P KA A P S SS + SSD EEE
Sbjct: 234 -----KAAATPKKTVPKKQVVAKAPVKA--------ATTPTRKSSSSEDSSSDEEEE--- 277
Query: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
K ++ K G S V SAP P+K PP K AV K Q + EDS S+
Sbjct: 278 QKKPMKNK-PGPYSSVPPPSAP---PPKKSLGTQPPKK---AVEKQQPVESSEDSSDESD 330
Query: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
S EE+ P P K K PP K+ +S
Sbjct: 331 SSSEEEKKP-----------------PTKAVVSKATTKPPP------------AKKAAES 361
Query: 476 RSSSEESDSDREALAAMNAAQVKPLG--KSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
S S +SDS + + A KP G K+ KPA T + A P P G
Sbjct: 362 SSDSSDSDSSED-----DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKL 416
Query: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG 593
+ + DS SS EESS S + + VA + K+ S PAK PQ +
Sbjct: 417 LTRKA-----DSSSSEEESSSSEEEKTKKMVATTKPKATAK----AALSLPAKQAPQGS- 466
Query: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL----KIPQTKACPKKTN 649
SS+ S S++ EE + +A + KP P A KK
Sbjct: 467 -------------RDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGK 513
Query: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES-DSEEEKTGL 708
+S + + K SP +P G + A++ +++ S + EEEK
Sbjct: 514 AESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKA 573
Query: 709 AVTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAPVLPGK-------TGPTVTQVKAEK 758
AV V ++ S+ K Q K A P + T P + + P + E
Sbjct: 574 AVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEI 633
Query: 759 QEDSESSEEESDSEEAAA 776
+ DS ++ D++ AA
Sbjct: 634 EVDSRVADNSFDAKRGAA 651
Score = 139 bits (351), Expect = 1e-32
Identities = 191/698 (27%), Positives = 260/698 (37%), Gaps = 196/698 (28%)
Query: 258 PPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATP 317
P AK+AKK S+S E+ SE EEE + A+ PAK
Sbjct: 73 PVAKKAKKKASSSDS-EDSSEEEEEVQGPP------------AKKAAVPAK------RVG 113
Query: 318 APPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAP 377
PPGKA A AS++ SSSEESSD ++E K +Q
Sbjct: 114 LPPGKAAAKASES----------SSSEESSDDDDEEDQKKQPVQKGVK------------ 151
Query: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
P+ AA APP K S S +S SE+E P KP V+
Sbjct: 152 ----PQAKAAKAPPKKA--------------KSSDSDSDSSSEDEPPKNQKPKITPVTVK 193
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
A + ++P K A AP G AA+ S SSS++S+ ++ A
Sbjct: 194 AQT----KAPPKPARAAPKIANGKAASS----SSSSSSSSSSDDSEEEKAAATPKKTVPK 245
Query: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD 557
K + VK A+T P K + S+ EE+ + ++
Sbjct: 246 KQVVAKAPVKAATT-------------PTRKSSSSEDSSSD---EEEEQKKPMKNKPGPY 289
Query: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
VP AP +KSLG PP+KA V+ ++P+++SE S + SDS
Sbjct: 290 SSVPPPSAPPPKKSLGT------------QPPKKA------VEKQQPVESSEDSSDESDS 331
Query: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAG 677
+ EE K P TKA K T K P +
Sbjct: 332 SSEEE--------------KKPPTKAVVSKATT----KPPPAK----------------- 356
Query: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737
+ AE SS S +SDS E+ + G K+ V S VK +
Sbjct: 357 ----------KAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPA--- 403
Query: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA--NPA 795
AP P G + KA DS SSEEES S E + V T+ K AKA +
Sbjct: 404 -AAPKQPVGGGQKLLTRKA----DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLP 458
Query: 796 AARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
A +AP S+ ++ + ++ S S VK + PQ + G A +
Sbjct: 459 AKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVK---KKPQK-----------VAGGAAPS 504
Query: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
A A+ G E S SS + SEEE E L K SPR P
Sbjct: 505 KPASAKKGKAESSNSSSSDDSSEEEEEKL-----------------KGKGSPR----PQA 543
Query: 916 PGKTGPSA--AQAGKQDDSGSSSEESDSDGEAPAAVTS 951
P G SA AQ GK + +SEE + + + A V S
Sbjct: 544 PKANGTSALTAQNGK---AAKNSEEEEEEKKKAAVVVS 578
Score = 138 bits (348), Expect = 2e-32
Identities = 169/658 (25%), Positives = 246/658 (37%), Gaps = 137/658 (20%)
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV----- 223
L S E + A G AK A SSS+ SS +E +V+G P+ K A
Sbjct: 58 LKSAKVPERKLQANGPVAKKAKKKA----SSSDSEDSSEEEEEVQGPPAKKAAVPAKRVG 113
Query: 224 ----KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES 279
KA++ +++ S + +++ + V+ G P AK AK P ++++SS+ S+S
Sbjct: 114 LPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDS 173
Query: 280 --EEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE 337
E+E P + ++ Q +A PA+ P GKA + +S
Sbjct: 174 SSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAP-----KIANGKAASSSS--------- 219
Query: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA 397
S SSS S DSEEE AA+ P K P+K P K
Sbjct: 220 -SSSSSSSSDDSEEEK-------------------AAATPKKTVPKKQVVAKAPVKAATT 259
Query: 398 VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457
+ SSSE+S S+EE + K + P+ P+K PP+
Sbjct: 260 PTR---------KSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK 310
Query: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL 517
K V+ + E S SS+ESDS E K P K
Sbjct: 311 KA------VEKQQPVESSEDSSDESDSSSEE------------EKKPPTKAV-------- 344
Query: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGN--I 575
V AT K +S S S +S S D E P+ A + S +
Sbjct: 345 -----------VSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAV 393
Query: 576 LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE--------EAPAAM 627
P PA P Q G Q + D+S S EESS S + + + A
Sbjct: 394 TTKSPAVKPAAAPKQPVG--GGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATA 451
Query: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK--AGTATSPAGSSPAVAGG 685
AA + PA + PQ + ++S++ + A +K A A S PA A
Sbjct: 452 KAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKK 511
Query: 686 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 745
+ + +SSSS++S EEE+ K GKG + AP G
Sbjct: 512 GKAESSNSSSSDDSSEEEEE----------KLKGKGSP-------------RPQAPKANG 548
Query: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK 803
+ T KA K +SEEE + ++ AA S+KK + A P AK
Sbjct: 549 TSALTAQNGKAAK-----NSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
Score = 98.6 bits (244), Expect = 2e-20
Identities = 119/434 (27%), Positives = 156/434 (35%), Gaps = 89/434 (20%)
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
GP A+ DSE SSEE + A PA+ L PP
Sbjct: 72 GPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGL---------------PP 116
Query: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
KA A + S SSEESSD D E+ KP K KA PKK
Sbjct: 117 GKAAAKASE---------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKA--AKAPPKKAK 165
Query: 650 TTAS---------------AKVAPVRVG--TQAPRKAGTATSPAGSSPAVAGGTQRPAED 692
++ S K+ PV V T+AP K PA ++P +A G +
Sbjct: 166 SSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPK------PARAAPKIANGKAASSSS 219
Query: 693 SSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT 750
SSSS S DSEEEK AA+ P K + P K T
Sbjct: 220 SSSSSSSSDDSEEEK--------------------AAATPKKTVPKKQVVAKAPVKAATT 259
Query: 751 VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPG 810
T+ K+ EDS S EEE + P + P + P K + P
Sbjct: 260 PTR-KSSSSEDSSSDEEEEQKKPMKNKPGPYSSV---------PPPSAPPPKKSLGTQPP 309
Query: 811 KVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS 870
K A KQ+ + +S+ + P + V KA A+ E S S
Sbjct: 310 K----KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS 365
Query: 871 SEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD 930
S+ +S ++EA + KP+G T A +SP A P G ++
Sbjct: 366 SDSDSSEDDEAPS----KPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA 421
Query: 931 DSGSSSEESDSDGE 944
DS SS EES S E
Sbjct: 422 DSSSSEEESSSSEE 435
Score = 63.9 bits (154), Expect = 7e-10
Identities = 73/300 (24%), Positives = 121/300 (40%), Gaps = 50/300 (16%)
Query: 73 AKKTRVSDPISTSESSEEEEEAEAETAKAT------PRLASTNSSVLGADLP-------- 118
AKK S S+ S E++EA ++ A T P + + + +V A P
Sbjct: 355 AKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
Query: 119 ----------SSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
SS +E + +E EK K + AT K +L + ++P+ S + S+++
Sbjct: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
Query: 169 LVSETEEE-----------------GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211
S EEE G+ P+ A+AK G A ++SSS D SS +E
Sbjct: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKG--KAESSNSSSSDDSSEEEEEK 532
Query: 212 VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV-----KGGALPPAKR--AK 264
++GK S +P KA+ S + KAA + + + K G+L K+ A
Sbjct: 533 LKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592
Query: 265 KPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAG 324
K E ++ + ++ P + + +AS +VR + A G AG
Sbjct: 593 KEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAG 652
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 129 bits (324), Expect = 1e-29
Identities = 213/869 (24%), Positives = 294/869 (33%), Gaps = 93/869 (10%)
Query: 78 VSDPISTSESSE-EEEEAEAETAKATPRL--ASTNSSVLGADLPSSMKEKAKAETEKAGK 134
+S P+S E+S E + +K +P + T S GA PS++ T + K
Sbjct: 824 LSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAV-------TPLSPK 876
Query: 135 TGNSMPHPATGKTVANLLSGK----SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
P +V NL K +P P+ + T S + + G A P
Sbjct: 877 GVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSP 936
Query: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTP 250
A +++ + T PA S +P+ K AP P P
Sbjct: 937 KGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAA--TPP 994
Query: 251 QVKGG-ALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPA-K 308
KGG A P K A P + S +GS + P G + A+ + A+ P K
Sbjct: 995 SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054
Query: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
G P A P K G K G P + ++ S TP+ K A+
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLK-GAPTPPA--ATPPSPKGGPATPSPKGAPMPPAATPP 1111
Query: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
S G + P P KGA P P T P+ A + + ++ + +
Sbjct: 1112 SPKGGLATP----PHKGA-PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATP 1166
Query: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPR--KTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
P AP AA+ P SP+ G A P+ T PAA S + S +
Sbjct: 1167 PPKGAPTTPAATPP---SPKGGLATPSPKGAPTTPAATP--------PSPKGGLATPSPK 1215
Query: 487 EALAAMNAAQVKPLG----KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
A A P G SP+ P + P KG PP K P P+A +
Sbjct: 1216 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLK 1275
Query: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
+ + + + P V P K P +SP KG P A
Sbjct: 1276 GGLATPPHKGAPN-----PAVVTPPSPKG-------GPATSPPKGAPTPPA-------AT 1316
Query: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
P S + P A+T K +P T K TT S+K P
Sbjct: 1317 PP---SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPA 1373
Query: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKT-GLAVTVGQAKSVGKG 721
K G A +P SP P D +S +K VT A + KG
Sbjct: 1374 ATPSHKGGPAMTPP--SPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKG 1431
Query: 722 LQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 781
A PV SL + A P K GP K D S + +P QV
Sbjct: 1432 DLTPPAVTPV--SLKKAPATSAP-KGGPATPSSKG----DPTLPAVTPPSPKEPPAPKQV 1484
Query: 782 KTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSP--------SKVKPPVRN 833
TS +A A PA AP+ I + K V A ++ R P SK P
Sbjct: 1485 ATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSR-RDPIAPTATLLSKKTPATLA 1543
Query: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
P+ + + P A+ T +A P SS+E S + + PS K
Sbjct: 1544 PKEALIPPAMTVPSPKKTPAIPTPKEAPATP-----SSKEASSPPAVTPSTYKGAPSPK- 1597
Query: 894 HQIRAALAPAKESPRKGAAPTPPGKTGPS 922
+ PA SP APTPP T PS
Sbjct: 1598 ---ELLIPPAVTSPSPKEAPTPPAVTPPS 1623
Score = 118 bits (296), Expect = 2e-26
Identities = 217/894 (24%), Positives = 316/894 (35%), Gaps = 140/894 (15%)
Query: 100 KATPRLASTNSSV-LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPR 158
K +P ST+SS + +++ +K+ E GK +SM P + A+++ S
Sbjct: 568 KNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYA 627
Query: 159 --KSAEPSANTTLVSETEEEGSVPAFGA-AAKPGMVSAGQADSSSEDTSSSSDETDVEGK 215
SA P ++L++ T V AF +A P V+ A +S T+++S +EG
Sbjct: 628 GPDSAGPLLKSSLITPT-----VAAFPLESADPAGVAPTTAKGTSTYTTTASPF--LEGT 680
Query: 216 PSVKPAQ--VKASSVST-------------KESPARKAAPAPGKV--GDVTPQVKGGALP 258
S+ P VK +++T SP AP V ++ V +LP
Sbjct: 681 VSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLP 740
Query: 259 PAKR---AKKPEEESESSEEG--SESEEEAPA--GTRSQVKASEKILQVRAASAPAKGTP 311
PA KK + S +S + S +E P S +S+ L A S G
Sbjct: 741 PAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVS 800
Query: 312 GKGATPAPPGKAGAVASQTKAGK------PEE-----DSESSSEESSDSEEET-----PA 355
T PP K G+ T G P E ++ S + S DS T P+
Sbjct: 801 VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPS 860
Query: 356 AKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSE 415
K A S G + P KE+P P K GPA
Sbjct: 861 PKGAPTPSAVTPLSPKGV-TLPPKETPTPSVVNLPFPKEGPA------------------ 901
Query: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPA--KESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
+ + ++APA + S + RA AP SP AP PP T P
Sbjct: 902 -TPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPP------------ 948
Query: 474 DSRSSSEESDSDREALAAMNAAQVKPLG----KSPQVKPASTMGMGPLGKGAGPVPPGKV 529
S + S + A A P G SP+ P P KG GP P
Sbjct: 949 -SPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKG-GPATPSPK 1006
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
G TP A + S +++ +S T +P + + + PT+ A P
Sbjct: 1007 GAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPS 1066
Query: 590 QKAGPVAVQVK-AEKPMDNSESSEESSDSADSEEA---PAAMTAAQAKPALKIPQTKACP 645
K GP +K A P + S + + S + P A T K L P K P
Sbjct: 1067 PKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAP 1126
Query: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
TT +A + G P G T+PA + P+ GG P + + + +
Sbjct: 1127 ----TTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP 1182
Query: 706 TGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT-----APVLPGKTGPTVTQVKAEKQE 760
G G A KG A+ P G T AP P T P + K
Sbjct: 1183 KG-----GLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP------SPKGG 1231
Query: 761 DSESSEEESDSEEAAASPA-QVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
+ S + + + AA P+ + + + P AA PS KG ++ P
Sbjct: 1232 LATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATP-------PHK 1284
Query: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
+P+ V PP +P+ GPA+ P G AA P+ G+ +
Sbjct: 1285 GAPNPAVVTPP--SPKG------GPATSPPKGAPTPPAA-TPPSPKGSPGTPPPKGAPTP 1335
Query: 880 EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
A T PS K A P+ KG TP K GP+ A G
Sbjct: 1336 PAVT----PPSPKGTPTLPATTPSS----KGGPTTPSSKEGPTPPAATPSHKGG 1381
Score = 114 bits (286), Expect = 3e-25
Identities = 208/930 (22%), Positives = 311/930 (33%), Gaps = 120/930 (12%)
Query: 78 VSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPS----SMKEKAKAETEKAG 133
+S + + + +E E + A+ +S + AD PS S+ + K K G
Sbjct: 754 ISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKG 813
Query: 134 KTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSV------PAFGAAAK 187
G P + NL S SP +++ N+ +++ + P+ A
Sbjct: 814 SAGPDTP-------IGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPT 866
Query: 188 PGMVSAGQADSSSEDTSSSSDETDV------EGKPSVKPAQVKASSVSTKESPARKAAPA 241
P V+ + + + V EG + P Q A S+++ +A PA
Sbjct: 867 PSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPA 926
Query: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301
P + +P KG PPA A P + + + PA T K +
Sbjct: 927 PKGI-PASPSPKGAPTPPA--ATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPK 983
Query: 302 AASAPAKGTP----GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
A P TP G ATP+P G A A P S + TP A
Sbjct: 984 GAPTPPAATPPSPKGGPATPSPKG-----APTPPAVTPPSPKGSPAATPFPKGASTPPAA 1038
Query: 358 ALLQAKASGKTSQV--GAASAPAKE--SPRKG-------AAPAPPGKTGPAVAKAQAGKR 406
K S + + GA + PA SP+ G AP PP T P+ A
Sbjct: 1039 TPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPS 1098
Query: 407 EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR--KTGPAAA 464
+ + + + P AP AA+ P SP+ G A PP+ T PAA
Sbjct: 1099 PKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPP---SPKGGLATPPPKGAPTTPAAT 1155
Query: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG----KSPQVKPASTMGMGPLGKG 520
S + + A A P G SP+ P + P KG
Sbjct: 1156 P--------PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1207
Query: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKP 580
P K P TP+A + + S + + ++ P A P+ +
Sbjct: 1208 GLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT----PAATPPSPKGGPATPPPKGA 1263
Query: 581 TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ 640
+ PA PP G +A P + + S A + A PA P
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAP----NPAVVTPPSPKGGPATSPPKGAPTPPAATPPS 1319
Query: 641 TKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD 700
K P T K AP P GT T PA ++P+ GG P+ + +
Sbjct: 1320 PKGSPG----TPPPKGAPTPPAVTPPSPKGTPTLPA-TTPSSKGGPTTPSSKEGPTPPAA 1374
Query: 701 SEEEKTGLAVTV-----GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755
+ K G A+T G A KG A +P L AP P VT+
Sbjct: 1375 TPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIP----LSPKKAPATP------VTR-- 1422
Query: 756 AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTA 815
+ ++ + D A +P +K + + K PA PS+KG + P
Sbjct: 1423 -----EGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPAT---PSSKGDPTLPAVT--- 1471
Query: 816 AAQAKQRSPSKVKPPV-RNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE 874
PS +PP + S+ + PA+ +G A A + P+E +
Sbjct: 1472 -------PPSPKEPPAPKQVATSSSPKKAPATPAPMG-APTLPAVIPSSPKEVPATPSSR 1523
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGS 934
D TL K A + PA P P P A + K+ S
Sbjct: 1524 RDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPP 1583
Query: 935 SSEESDSDGE-------APAAVTSAQDQES 957
+ S G P AVTS +E+
Sbjct: 1584 AVTPSTYKGAPSPKELLIPPAVTSPSPKEA 1613
Score = 89.7 bits (221), Expect = 1e-17
Identities = 163/707 (23%), Positives = 261/707 (36%), Gaps = 96/707 (13%)
Query: 216 PSVKPAQVKASSVSTKESPA----RKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE 271
P P +S K++PA R+ A P K GD+TP A+ P K P +
Sbjct: 1398 PKGDPTSPAVIPLSPKKAPATPVTREGAATPSK-GDLTPP----AVTPVSLKKAPATSAP 1452
Query: 272 S---SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
+ S+ + PA T K QV +S+P K ATPAP G A
Sbjct: 1453 KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAP----ATPAPMG-----AP 1503
Query: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
A P E + SS + P A L S KT PA +P++ A
Sbjct: 1504 TLPAVIPSSPKEVPATPSSRRDPIAPTATLL-----SKKT--------PATLAPKE--AL 1548
Query: 389 APPGKTGPAVAKAQA--GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
PP T P+ K A +E + SS+E+ S +P+ PA S
Sbjct: 1549 IPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPK-ELLIPPAVTS 1607
Query: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV 506
P AP PP T P+ + + + +S + S L SP
Sbjct: 1608 PSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSS--------------LKDSPTS 1653
Query: 507 KPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAP 566
+ T MG A P K GP +E + + ES+ PT P
Sbjct: 1654 PASVTCKMGATVPQASKGLPAKKGPTA-------LKEVLVAPAPESTPIITA--PTRKGP 1704
Query: 567 AQEKSLGNILQAKPTSSP---AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEA 623
+KS P S +KGP P + + +K + +++S S A
Sbjct: 1705 QTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPL-LPVQKDSSKTAKGKDASHSPKGPLA 1763
Query: 624 P------AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA- 676
P +TAA + L P++ + + S +AP V T P++ +SP
Sbjct: 1764 PPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGL 1823
Query: 677 ---GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPV-K 732
S +A + E + V + KS G + +A PV K
Sbjct: 1824 VLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTK 1883
Query: 733 GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA 792
+ G GT ++ + + E+Q+ ++++ ++ ++ AAA+ + K Q+++
Sbjct: 1884 NNKGSGT------ESDSDESVPELEEQDSTQATTQQ--AQLAAAAEIDEEPVSKAKQSRS 1935
Query: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPV-RNPQNSTVLARGPASVPSVG 851
A +A S G G ++K KP V ++P + T + G A + +
Sbjct: 1936 EKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLS 1995
Query: 852 KAVATAAQAQTGPEEDSGSS----------EEESDSEEEAETLAQVK 888
+ AA + + ++ S+ +EES+ EE ET +VK
Sbjct: 1996 QQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVK 2042
Score = 80.1 bits (196), Expect = 9e-15
Identities = 184/786 (23%), Positives = 277/786 (35%), Gaps = 151/786 (19%)
Query: 100 KATPRLASTNSSVLGADLPSSMKE----KAKAETEKAG--------KTGNSMPHPATGKT 147
K TP L +T S G S KE A + K G K G ++P P G
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPK-GDP 1402
Query: 148 VANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM--VSAGQADSSSEDTSS 205
+ + SP+K+ T E + P+ G P + VS +A ++S
Sbjct: 1403 TSPAVIPLSPKKAPATPV-------TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGG 1455
Query: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARK--AAPAPGKVGDVTPQVKGGALPPAKRA 263
+ + +G P++ PA + S KE PA K A + K TP G PA
Sbjct: 1456 PATPSS-KGDPTL-PA---VTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIP 1510
Query: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
P+E + S + AP T K + A PA P TPA P
Sbjct: 1511 SSPKEVPATPS--SRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK 1568
Query: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383
A A+ SS+E+S TP+ G S PA SP
Sbjct: 1569 EAPATP------------SSKEASSPPAVTPSTY-------KGAPSPKELLIPPAVTSPS 1609
Query: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVR 437
AP PP T P+ K A + + + SS + A K PQ
Sbjct: 1610 PKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQA- 1668
Query: 438 AASAPAKESPR--KGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREA------ 488
+ PAK+ P K AP P T A + G Q + S ++S D A
Sbjct: 1669 SKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG 1728
Query: 489 -LAAMNAAQVKPL----GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543
L+ + A + P+ K+ + K AS GPL P K +A K
Sbjct: 1729 PLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAP-----PESKASTPLTAAAFEKVLP 1783
Query: 544 DSESSSEESSDSSDGEVPTA----------------------------VAPAQEKSLGNI 575
ES+S ++ S +P A +APA E L +
Sbjct: 1784 KPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPL 1843
Query: 576 LQAKPTSSPA--------KGPPQKAGPVAVQVKAEKPM-DNSESSEESSDSADS------ 620
+ +P S P+ AG A++P+ N++ S SDS +S
Sbjct: 1844 IPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEE 1903
Query: 621 -EEAPAAMTAAQAKPALKI---PQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
+ A AQ A +I P +KA K++ + A+ A ++G + + G
Sbjct: 1904 QDSTQATTQQAQLAAAAEIDEEPVSKA--KQSRSEKKARKAMSKLGLR--QVTGVTRVTI 1959
Query: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLG 736
S + +P D S SD+ + G+AK Q + A+ G
Sbjct: 1960 RKSKNILFVITKP--DVYKSPASDT-------YIVFGEAKIEDLSQQAQLAAAEKFKVQG 2010
Query: 737 QGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAA 796
+ + + PTV +EES+ EE + +VK ++ ++AN +
Sbjct: 2011 EAVSNIQENTQTPTV--------------QEESEEEEVDETGVEVK-DIELVMSQANVSR 2055
Query: 797 ARAPSA 802
A+A A
Sbjct: 2056 AKAVRA 2061
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 115 bits (288), Expect = 2e-25
Identities = 155/595 (26%), Positives = 241/595 (40%), Gaps = 98/595 (16%)
Query: 159 KSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS-SDETDVEGKPS 217
+ E + T V+E EE+ + G + G +A+ E+T S ++E K +
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGG--EEEEAEGGEEETKSPPAEEAASPEKEA 516
Query: 218 VKPAQVKASSVSTKESPARKAAPAPGKVGDV----TPQVKGGALPPAKRAKKPEEESESS 273
P + +A S + +SP ++ A +P +V +P + PP AK PE+E S
Sbjct: 517 KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPP--EAKSPEKEEAKS 574
Query: 274 EEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VAS 328
+S E+A + + + K+ + A +P K A P K A V S
Sbjct: 575 PAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKS 634
Query: 329 QTKAGKPEEDSESSSEE--SSDSEEETPAAKALLQAKASGKTSQVGA------------A 374
KA P ++ S E+ S + EE KA KA K+ + A
Sbjct: 635 PEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKA 694
Query: 375 SAPAKE---SPRKGAAPAPPGKTGPAVAKA----QAGKREEDSQSSSEESDSEEEA--PA 425
+P KE SP K +P P AK+ +A E+ EE+ S E+A P
Sbjct: 695 KSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPE 754
Query: 426 QAK------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS 479
+AK P K P A +PA + P K +P P A+ + +ED+++
Sbjct: 755 KAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPL---KEDAKAPE 811
Query: 480 EESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV----GPATPS 535
+E E + VK K +VK PP K PATP
Sbjct: 812 KEIPKKEEV-----KSPVKEEEKPQEVKVKE--------------PPKKAEEEKAPATP- 851
Query: 536 AQVGKWEEDSESSSEES--SDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK---GPPQ 590
K EE +S EE+ ++ +V PA EK + ++AK + K P+
Sbjct: 852 ----KTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 591 KAGPVAVQVKAE-KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
K P V+VK + KP + +E +++ D A ++E +KPA K +A P+K +
Sbjct: 908 KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE--------PSKPAEK---KEAAPEKKD 956
Query: 650 T-TASAKVAPVRVGTQAPRKAGTAT-SPAGSSPAVAGGTQRPAEDSSSSEESDSE 702
T AK + T+A K T S S P AE SSS+++ DS+
Sbjct: 957 TKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKA-----EKAEKSSSTDQKDSK 1006
Score = 110 bits (274), Expect = 8e-24
Identities = 150/690 (21%), Positives = 254/690 (36%), Gaps = 102/690 (14%)
Query: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVK-ASEKILQVRA 302
K+ V+ +K + K +K E+E+ EE +E + T + K A E+ +
Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
+ G+ T +PP + A + +E+++S +E S +EE + +
Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547
Query: 363 KASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEE 422
+ + ++ A S P +SP K A +P P AK+ A ++ S E+ S E+
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPA----KEEAKSPAEAKSPEK 603
Query: 423 APAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES 482
A + K K+P A +P KE + A P K + + + E+ EE+
Sbjct: 604 AKSPVKEEAKSP--AEAKSPVKEEAKSPAEVKSPEK-AKSPTKEEAKSPEKAKSPEKEEA 660
Query: 483 DSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWE 542
S +A + VK KSP+ K PV P
Sbjct: 661 KSPEKA-----KSPVKAEAKSPE-------------KAKSPVKAEAKSP----------- 691
Query: 543 EDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
E ++S +E + S + A +P +E++ P AK P + PV + K+
Sbjct: 692 EKAKSPVKEEAKSPE----KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP 747
Query: 603 KPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVG 662
+ + E ++ + + PA A PA K P+ AK +PV+
Sbjct: 748 EKAKSPEKAKTLDVKSPEAKTPAKEEA--RSPADKFPE------------KAK-SPVKEE 792
Query: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
++P KA SP ED+ + E+ ++E+ V K K
Sbjct: 793 VKSPEKA--------KSPL--------KEDAKAPEKEIPKKEEVKSPV-----KEEEKPQ 831
Query: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK 782
+VK P K + A P + K K+E++ E E PA K
Sbjct: 832 EVKVKEPPKKAEEEKAPAT-------PKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK 884
Query: 783 TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR 842
K +AK A K + P K A + K+ + K K V + A+
Sbjct: 885 PKESKVEAKKEEA-----EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939
Query: 843 GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
P+ A + + PE+ E+ EE+ +T A+ K KT +
Sbjct: 940 EPSK---------PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPK 990
Query: 903 AKESPRKGAA----PTPPGKTGPSAAQAGK 928
A+++ + + PP K A GK
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 109 bits (272), Expect = 1e-23
Identities = 131/580 (22%), Positives = 229/580 (39%), Gaps = 74/580 (12%)
Query: 407 EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA-APAPPRKTGPAAAQ 465
EE+ + + EE EEE + + G + ++ A SP K A +P PA A+
Sbjct: 472 EEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAK 531
Query: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
++E+++S +E ++ A A+ P KSP+ + A +
Sbjct: 532 ---SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS-------------- 574
Query: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPT-AVAPAQEKSLGNILQAKPTSSP 584
A+V E+ + EE+ ++ + P A +P +E++ P
Sbjct: 575 ---------PAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKA 643
AK P + P KA+ P S E + S + EEA + A + K K P+
Sbjct: 626 AKSPAEVKSPE----KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 644 CPKKTNTTASAKV-APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSE 702
P K + K +PV+ ++P KA + SP A + E++ + E++ S
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK--EEAKTPEKAKSP 739
Query: 703 EEKTGLAVTVGQAKSVGKGLQVKA--ASVPVKGSLGQGTAPVLPGKT-GPTVTQVKAEKQ 759
++ + ++ K L VK+ A P K + A P K P +VK+ ++
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE-ARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 760 ------EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV 813
ED+++ E+E +E SP + + ++ + K P A A T K
Sbjct: 799 AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKD 858
Query: 814 TAAAQAKQRSPSKVK------PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEED 867
+ +A ++ K K P V P+ S V A+ K A + PE++
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK---------KEEAEDKKKVPTPEKE 909
Query: 868 SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP---------TPPGK 918
+ + E +E+A+ + + + K A P+K + +K AAP +
Sbjct: 910 APAKVEV---KEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE 966
Query: 919 TGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958
P K+DD S E S E A +S+ DQ+ S
Sbjct: 967 EKPKTEAKAKEDDKTLSKEPSKPKAE-KAEKSSSTDQKDS 1005
Score = 95.1 bits (235), Expect = 3e-19
Identities = 129/551 (23%), Positives = 202/551 (36%), Gaps = 66/551 (11%)
Query: 66 EEDAALQAKKTRVSDPISTSESSEEE------EEAEAETAKATPRLASTNSSVLGADLPS 119
EE+ A ++ S P + S E+E EEA++ +P S A++ S
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSP---AEVKS 546
Query: 120 SMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSV 179
K K+ A+ E P K+ A + S + + A+ A + +++ E+
Sbjct: 547 PEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKS 606
Query: 180 PAFGAAAKPGMVSAGQADSSSEDTSSSSDE-----TDVEGKPSVK---PAQVKASSVSTK 231
P A P + + + S E T E K K P + +A S
Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKA 666
Query: 232 ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEG-SESEEEAPAGTRSQ 290
+SP + A +P K VK A P K +EE++S E+ S +EEA + +++
Sbjct: 667 KSPVKAEAKSPEKAKS---PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAK 723
Query: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
E+ A +P K P KA + ++ K E+ S E
Sbjct: 724 SPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
Query: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP---PGKTGPAVAKAQAGKRE 407
+ K +++ K+ A AP KE P+K +P K K K E
Sbjct: 784 KAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE 843
Query: 408 ED----SQSSSEESDSE-EEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA-------- 454
E+ + + E+ DS+ EEAP + P P+V PA E P++ A
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPK---PKVEEKKEPAVEKPKESKVEAKKEEAEDK 900
Query: 455 ----PPRKTGPAAAQV----------QVGKQEEDSRSSSEESDSDREALAAMNAAQVK-P 499
P K PA +V +V K+E D + E S + AA K
Sbjct: 901 KKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960
Query: 500 LGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGE 559
K P+ KP + K P+ P A E+ +SSS + DS E
Sbjct: 961 KAKKPEEKPKTE------AKAKEDDKTLSKEPSKPKA-----EKAEKSSSTDQKDSKPPE 1009
Query: 560 VPTAVAPAQEK 570
T A+ K
Sbjct: 1010 KATEDKAAKGK 1020
Score = 63.5 bits (153), Expect = 9e-10
Identities = 59/214 (27%), Positives = 103/214 (48%), Gaps = 26/214 (12%)
Query: 751 VTQVKAEKQEDSESSEEESDSE---------------EAAASPAQVKTSVKKTQAKANPA 795
VT+ + ++ ++ E EEE E E AASP + S K +AK +PA
Sbjct: 470 VTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAK-SPA 528
Query: 796 AARAPSAKGTISAPGKVVT-AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV 854
A++P K +P +V + A++ + +K P ++P+ A+ PA V S KA
Sbjct: 529 EAKSPE-KEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE--AKSPAEVKSPEKAK 585
Query: 855 ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK-ESPRKGAAP 913
+ A + P E + +S +EEA++ A+ K K A +PA+ +SP K +P
Sbjct: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK----EEAKSPAEVKSPEKAKSP 641
Query: 914 TPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA 947
T P A++ +++++ S E++ S +A A
Sbjct: 642 TKEEAKSPEKAKSPEKEEA-KSPEKAKSPVKAEA 674
Score = 39.3 bits (90), Expect = 0.018
Identities = 39/161 (24%), Positives = 68/161 (42%), Gaps = 16/161 (9%)
Query: 811 KVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT-------- 862
K+ + + K +S K+K V + TV+ V + V + +
Sbjct: 428 KIPSVSTHIKVKSEEKIKV-VEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEE 486
Query: 863 --GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK-ESPRKGAAPTPPGKT 919
G EE++ EEE+ S AE A + K+ A +PA+ +SP K A +P
Sbjct: 487 EGGEEEEAEGGEEETKS-PPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 920 GPSAAQAGKQDDSGSSSEESDSDGE---APAAVTSAQDQES 957
P A++ ++++ S E + E +PA V S + +S
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 114 bits (286), Expect = 3e-25
Identities = 172/875 (19%), Positives = 301/875 (34%), Gaps = 121/875 (13%)
Query: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
+QTS G+++ +KT D TS+ + +AET P L +
Sbjct: 160 KQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT- 217
Query: 114 GADLPSSMKEKAKAE-------TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
P++ KE A T K+ T P P T K+ +P + EP+
Sbjct: 218 ----PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 273
Query: 167 TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE-----TDVEGKPSVK-- 219
T PA +P + A ++ ++ + ++ + T E P+
Sbjct: 274 TP---------KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 324
Query: 220 --PAQVKASSVSTKE----SPARKAAPAPGKVGDVTPQVKGGALP--PAKRAKKPEEESE 271
P K + +TKE +P A AP K TP+ P PA K +
Sbjct: 325 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 384
Query: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK---AGAVAS 328
E + + AP T+ + K A + P + +P PAP A
Sbjct: 385 PKEPAPTTTKSAPTTTKEPAPTTTK----SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 440
Query: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR--KGA 386
+ P+E + ++ +E + + + PA + + T + A + P K +P +
Sbjct: 441 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTT--PKEPAPTTPKETAPTTPKKLTPTTPEKL 498
Query: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
AP P K P + A E+ ++ E + A A + K P PA +
Sbjct: 499 APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT 558
Query: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE----------ALAAMNAAQ 496
P++ AP P++T P + ++ ++ + + +E + A
Sbjct: 559 PKE-PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 617
Query: 497 VKPLGKSPQV--KPASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEE 551
P G +P +PA T P KG P + P TP K E ++
Sbjct: 618 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGP 676
Query: 552 SSDSSDGEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+S +SD PT AP K KP + + PP V+ ++P
Sbjct: 677 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 736
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+S +ES+ +E P A+ + +P + +T A K TT + K
Sbjct: 737 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA--------------K 782
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T ++P + ++++++ E +E ++ A +
Sbjct: 783 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTES-------------------KITATT 823
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
V + Q T P T K + + ++ E + E A P
Sbjct: 824 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-------- 875
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
RA ++K T P K A + K P VR P+ + + +++P
Sbjct: 876 ---------RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 926
Query: 849 SV---GKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
+ + Q T P + S E + + E
Sbjct: 927 ELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 961
Score = 101 bits (251), Expect = 4e-21
Identities = 165/900 (18%), Positives = 311/900 (34%), Gaps = 97/900 (10%)
Query: 66 EEDAALQAKKTRVSDP-ISTSESSEEEEEAEAETAKA-TPRLASTNSSVLGADLPSSMKE 123
E + L +V+ P ST++ ++ + TAK PR + +S + ++ +
Sbjct: 87 EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNK 146
Query: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
+ ET++ T N + ++ + T + +T + P
Sbjct: 147 ETTVETKET--------------TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 192
Query: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPG 243
AKP + + T T + S P + +++ + + ++ AP
Sbjct: 193 VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 252
Query: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
K TP+ P K+P + + ++E AP T+S ++
Sbjct: 253 KSAPTTPKE-----PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE------- 300
Query: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK 363
PA TP K A P A + P+E + ++ E + + +E PA A K
Sbjct: 301 --PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE-PAPTA--PKK 355
Query: 364 ASGKTSQVGAASAPAKESPRKGAAPAP--PGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421
+ T + A + P + +P P+P P + P K+ +E + ++++ + +
Sbjct: 356 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 415
Query: 422 EAPAQA---KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
+ P+ +P+ P+ A + P K +P PAP PA +
Sbjct: 416 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----------- 464
Query: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQV 538
KP +P+ +PA T K P P K+ P TP
Sbjct: 465 -------------------KPAPTTPK-EPAPT-----TPKETAPTTPKKLTPTTPEKLA 499
Query: 539 GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT-SSPAKGPPQKAGPVAV 597
E ++ E + E PT P + A T PA P++ P
Sbjct: 500 PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 559
Query: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 657
+ A + + + + + PA T + P P T P T A
Sbjct: 560 KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 619
Query: 658 PVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA--EDSSSSEESDSEEEKTGLAVTVGQA 715
P P K T+P +P GT E + ++ + + +E A
Sbjct: 620 PKGTAPTTP-KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKE---------LA 669
Query: 716 KSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAA 775
+ KG + P + + TAP P + PT + A + + + SE +
Sbjct: 670 PTTTKGPTSTTSDKPAP-TTPKETAPTTPKEPAPTTPKKPA---PTTPETPPPTTSEVST 725
Query: 776 ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQ 835
+ + T++ K+ ++ P + P+ K ++P + ++P+ KP +
Sbjct: 726 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE----PGVPTTKTPAATKPEMTTTA 781
Query: 836 NSTVLARGPASVPSVGKAV-ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH 894
R + P A + T E+ + S + ++ + T P T
Sbjct: 782 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITT 841
Query: 895 QIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
LAP + +K T K +A + +S +++ + +AP TS +
Sbjct: 842 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 901
Score = 42.4 bits (98), Expect = 0.002
Identities = 76/393 (19%), Positives = 135/393 (34%), Gaps = 71/393 (18%)
Query: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-----APAAMT 628
N + KPT P V +A +DN + + D++ ++ +P T
Sbjct: 72 NRTKKKPTPKPP-----------VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT 120
Query: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR 688
A P +P K+T+ T + + T K T T+ S+
Sbjct: 121 AKPINPRPSLPPNSDTSKETSLTVNKE-------TTVETKETTTTNKQTST--------- 164
Query: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
D +E+ T T K+ K L P L + T G
Sbjct: 165 -----------DGKEKTTSAKETQSIEKTSAKDL------APTSKVLAKPTPKAETTTKG 207
Query: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
P +T K+ + +E + + +P +K++ PA SA T
Sbjct: 208 PALT---TPKEPTPTTPKEPASTTPKEPTPTTIKSA---PTTPKEPAPTTTKSAPTTPKE 261
Query: 809 PGKVVT---AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
P T A K+ +P+ K P + + + P A T P+
Sbjct: 262 PAPTTTKEPAPTTPKEPAPTTTKEP------APTTTKSAPTTPKEPAPTTPKKPAPTTPK 315
Query: 866 EDSGSSEEESDSEEEAETLAQVK-PSGKTHQIRAALAPAKESPR--KGAAPTPPGKTGPS 922
E + ++ +E E K P+ T + A AP K +P K APT P + P+
Sbjct: 316 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 375
Query: 923 AAQ----AGKQDDSGSSSEESDSDGEAPAAVTS 951
+ ++ + ++++ + + + PA T+
Sbjct: 376 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 408
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 114 bits (286), Expect = 3e-25
Identities = 172/875 (19%), Positives = 301/875 (34%), Gaps = 121/875 (13%)
Query: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
+QTS G+++ +KT D TS+ + +AET P L +
Sbjct: 201 KQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT- 258
Query: 114 GADLPSSMKEKAKAE-------TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
P++ KE A T K+ T P P T K+ +P + EP+
Sbjct: 259 ----PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 314
Query: 167 TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE-----TDVEGKPSVK-- 219
T PA +P + A ++ ++ + ++ + T E P+
Sbjct: 315 TP---------KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 365
Query: 220 --PAQVKASSVSTKE----SPARKAAPAPGKVGDVTPQVKGGALP--PAKRAKKPEEESE 271
P K + +TKE +P A AP K TP+ P PA K +
Sbjct: 366 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 425
Query: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK---AGAVAS 328
E + + AP T+ + K A + P + +P PAP A
Sbjct: 426 PKEPAPTTTKSAPTTTKEPAPTTTK----SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 481
Query: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR--KGA 386
+ P+E + ++ +E + + + PA + + T + A + P K +P +
Sbjct: 482 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTT--PKEPAPTTPKETAPTTPKKLTPTTPEKL 539
Query: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
AP P K P + A E+ ++ E + A A + K P PA +
Sbjct: 540 APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT 599
Query: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE----------ALAAMNAAQ 496
P++ AP P++T P + ++ ++ + + +E + A
Sbjct: 600 PKE-PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 658
Query: 497 VKPLGKSPQV--KPASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEE 551
P G +P +PA T P KG P + P TP K E ++
Sbjct: 659 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGP 717
Query: 552 SSDSSDGEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+S +SD PT AP K KP + + PP V+ ++P
Sbjct: 718 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 777
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+S +ES+ +E P A+ + +P + +T A K TT + K
Sbjct: 778 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA--------------K 823
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T ++P + ++++++ E +E ++ A +
Sbjct: 824 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTES-------------------KITATT 864
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
V + Q T P T K + + ++ E + E A P
Sbjct: 865 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-------- 916
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
RA ++K T P K A + K P VR P+ + + +++P
Sbjct: 917 ---------RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 967
Query: 849 SV---GKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
+ + Q T P + S E + + E
Sbjct: 968 ELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1002
Score = 101 bits (251), Expect = 4e-21
Identities = 165/900 (18%), Positives = 311/900 (34%), Gaps = 97/900 (10%)
Query: 66 EEDAALQAKKTRVSDP-ISTSESSEEEEEAEAETAKA-TPRLASTNSSVLGADLPSSMKE 123
E + L +V+ P ST++ ++ + TAK PR + +S + ++ +
Sbjct: 128 EAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNK 187
Query: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
+ ET++ T N + ++ + T + +T + P
Sbjct: 188 ETTVETKET--------------TTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSK 233
Query: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPG 243
AKP + + T T + S P + +++ + + ++ AP
Sbjct: 234 VLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 293
Query: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
K TP+ P K+P + + ++E AP T+S ++
Sbjct: 294 KSAPTTPKE-----PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE------- 341
Query: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK 363
PA TP K A P A + P+E + ++ E + + +E PA A K
Sbjct: 342 --PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE-PAPTA--PKK 396
Query: 364 ASGKTSQVGAASAPAKESPRKGAAPAP--PGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421
+ T + A + P + +P P+P P + P K+ +E + ++++ + +
Sbjct: 397 PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTP 456
Query: 422 EAPAQA---KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
+ P+ +P+ P+ A + P K +P PAP PA +
Sbjct: 457 KEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK----------- 505
Query: 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQV 538
KP +P+ +PA T K P P K+ P TP
Sbjct: 506 -------------------KPAPTTPK-EPAPT-----TPKETAPTTPKKLTPTTPEKLA 540
Query: 539 GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT-SSPAKGPPQKAGPVAV 597
E ++ E + E PT P + A T PA P++ P
Sbjct: 541 PTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP 600
Query: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 657
+ A + + + + + PA T + P P T P T A
Sbjct: 601 KEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTT 660
Query: 658 PVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA--EDSSSSEESDSEEEKTGLAVTVGQA 715
P P K T+P +P GT E + ++ + + +E A
Sbjct: 661 PKGTAPTTP-KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKE---------LA 710
Query: 716 KSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAA 775
+ KG + P + + TAP P + PT + A + + + SE +
Sbjct: 711 PTTTKGPTSTTSDKPAP-TTPKETAPTTPKEPAPTTPKKPA---PTTPETPPPTTSEVST 766
Query: 776 ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQ 835
+ + T++ K+ ++ P + P+ K ++P + ++P+ KP +
Sbjct: 767 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE----PGVPTTKTPAATKPEMTTTA 822
Query: 836 NSTVLARGPASVPSVGKAV-ATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH 894
R + P A + T E+ + S + ++ + T P T
Sbjct: 823 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITT 882
Query: 895 QIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
LAP + +K T K +A + +S +++ + +AP TS +
Sbjct: 883 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 942
Score = 42.4 bits (98), Expect = 0.002
Identities = 76/393 (19%), Positives = 135/393 (34%), Gaps = 71/393 (18%)
Query: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE-----APAAMT 628
N + KPT P V +A +DN + + D++ ++ +P T
Sbjct: 113 NRTKKKPTPKPP-----------VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITT 161
Query: 629 AAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQR 688
A P +P K+T+ T + + T K T T+ S+
Sbjct: 162 AKPINPRPSLPPNSDTSKETSLTVNKE-------TTVETKETTTTNKQTST--------- 205
Query: 689 PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
D +E+ T T K+ K L P L + T G
Sbjct: 206 -----------DGKEKTTSAKETQSIEKTSAKDL------APTSKVLAKPTPKAETTTKG 248
Query: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
P +T K+ + +E + + +P +K++ PA SA T
Sbjct: 249 PALT---TPKEPTPTTPKEPASTTPKEPTPTTIKSA---PTTPKEPAPTTTKSAPTTPKE 302
Query: 809 PGKVVT---AAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
P T A K+ +P+ K P + + + P A T P+
Sbjct: 303 PAPTTTKEPAPTTPKEPAPTTTKEP------APTTTKSAPTTPKEPAPTTPKKPAPTTPK 356
Query: 866 EDSGSSEEESDSEEEAETLAQVK-PSGKTHQIRAALAPAKESPR--KGAAPTPPGKTGPS 922
E + ++ +E E K P+ T + A AP K +P K APT P + P+
Sbjct: 357 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 416
Query: 923 AAQ----AGKQDDSGSSSEESDSDGEAPAAVTS 951
+ ++ + ++++ + + + PA T+
Sbjct: 417 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT 449
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 114 bits (286), Expect = 3e-25
Identities = 172/875 (19%), Positives = 301/875 (34%), Gaps = 121/875 (13%)
Query: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
+QTS G+++ +KT D TS+ + +AET P L +
Sbjct: 253 KQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT- 310
Query: 114 GADLPSSMKEKAKAE-------TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
P++ KE A T K+ T P P T K+ +P + EP+
Sbjct: 311 ----PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 366
Query: 167 TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE-----TDVEGKPSVK-- 219
T PA +P + A ++ ++ + ++ + T E P+
Sbjct: 367 TP---------KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 417
Query: 220 --PAQVKASSVSTKE----SPARKAAPAPGKVGDVTPQVKGGALP--PAKRAKKPEEESE 271
P K + +TKE +P A AP K TP+ P PA K +
Sbjct: 418 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 477
Query: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK---AGAVAS 328
E + + AP T+ + K A + P + +P PAP A
Sbjct: 478 PKEPAPTTTKSAPTTTKEPAPTTTK----SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 533
Query: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR--KGA 386
+ P+E + ++ +E + + + PA + + T + A + P K +P +
Sbjct: 534 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTT--PKEPAPTTPKETAPTTPKKLTPTTPEKL 591
Query: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
AP P K P + A E+ ++ E + A A + K P PA +
Sbjct: 592 APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT 651
Query: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE----------ALAAMNAAQ 496
P++ AP P++T P + ++ ++ + + +E + A
Sbjct: 652 PKE-PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 710
Query: 497 VKPLGKSPQV--KPASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEE 551
P G +P +PA T P KG P + P TP K E ++
Sbjct: 711 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGP 769
Query: 552 SSDSSDGEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+S +SD PT AP K KP + + PP V+ ++P
Sbjct: 770 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 829
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+S +ES+ +E P A+ + +P + +T A K TT + K
Sbjct: 830 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA--------------K 875
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T ++P + ++++++ E +E ++ A +
Sbjct: 876 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTES-------------------KITATT 916
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
V + Q T P T K + + ++ E + E A P
Sbjct: 917 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-------- 968
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
RA ++K T P K A + K P VR P+ + + +++P
Sbjct: 969 ---------RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1019
Query: 849 SV---GKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
+ + Q T P + S E + + E
Sbjct: 1020 ELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1054
Score = 102 bits (254), Expect = 2e-21
Identities = 166/915 (18%), Positives = 316/915 (34%), Gaps = 91/915 (9%)
Query: 58 ELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAE-----AETAKATPRLASTNSSV 112
EL +K K +++ + KK P E+ + + +T+ ST+ +
Sbjct: 152 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKI 211
Query: 113 LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSP----RKSAEPSANTT 168
A P + + ++ + +T ++ T +T + K ++ + T
Sbjct: 212 TTAK-PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 270
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
+ +T + P AKP + + T T + S P + +++
Sbjct: 271 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 330
Query: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
+ + ++ AP K TP+ P K+P + + ++E AP T+
Sbjct: 331 KSAPTTPKEPAPTTTKSAPTTPKE-----PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 385
Query: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 348
S ++ PA TP K A P A + P+E + ++ E +
Sbjct: 386 SAPTTPKE---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT 436
Query: 349 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP--PGKTGPAVAKAQAGKR 406
+ +E PA A K + T + A + P + +P P+P P + P K+
Sbjct: 437 TPKE-PAPTA--PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 493
Query: 407 EEDSQSSSEESDSEEEAPAQA---KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
+E + ++++ + + + P+ +P+ P+ A + P K +P PAP PA
Sbjct: 494 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 553
Query: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGP 523
+ KP +P+ +PA T K P
Sbjct: 554 TTTK------------------------------KPAPTTPK-EPAPT-----TPKETAP 577
Query: 524 VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT-S 582
P K+ P TP E ++ E + E PT P + A T
Sbjct: 578 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 637
Query: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
PA P++ P + A + + + + + PA T + P P T
Sbjct: 638 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 697
Query: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA--EDSSSSEESD 700
P T A P P K T+P +P GT E + ++ +
Sbjct: 698 KEPTSTTCDKPAPTTPKGTAPTTP-KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 756
Query: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
+ +E A + KG + P + + TAP P + PT + A
Sbjct: 757 APKE---------LAPTTTKGPTSTTSDKPAP-TTPKETAPTTPKEPAPTTPKKPA---P 803
Query: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
+ + + SE + + + T++ K+ ++ P + P+ K ++P +
Sbjct: 804 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE----PGVPT 859
Query: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV-ATAAQAQTGPEEDSGSSEEESDSEE 879
++P+ KP + R + P A + T E+ + S + ++
Sbjct: 860 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 919
Query: 880 EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGKQDDSGSSSEE 938
+ T P T LAP + +K T K +A + +S +++ +
Sbjct: 920 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 979
Query: 939 SDSDGEAPAAVTSAQ 953
+AP TS +
Sbjct: 980 PQKPTKAPKKPTSTK 994
Score = 99.8 bits (247), Expect = 1e-20
Identities = 166/837 (19%), Positives = 280/837 (33%), Gaps = 83/837 (9%)
Query: 148 VANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAG--QADSSSEDTSS 205
V N S S +K+ PS + + T + P K + S + S SE+ S
Sbjct: 66 VHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQES 125
Query: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
SS + +++ + +S + +E + +VK K+
Sbjct: 126 SSSSSSSSSSSTIRKIKSSKNSAANRELQKKL-------------KVKDNKKNRTKKKPT 172
Query: 266 PE----EESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRAASAPAKGTPGKGATPA 318
P+ +E+ S + + + P + +Q V S KI + + P P T
Sbjct: 173 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN-PRPSLPPNSDTSK 231
Query: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL-----LQAKASGKTSQVGA 373
+ ++ + +E + ++ + S+D +E+T +AK AK TS+V A
Sbjct: 232 ---ETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 288
Query: 374 ASAPAKESPRKGAA---PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
P E+ KG A P P T P + K + S + +E AP K +
Sbjct: 289 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 348
Query: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ----VGKQEEDSRSSSEESDSDR 486
P+ A + + +P PAP PA + K+ + + +
Sbjct: 349 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 408
Query: 487 EALAAMNAAQVKPLGKSP---QVKPASTMGMGP---LGKGAGPVPPGKVGPATPSAQV-G 539
E K P +PA T P K P P + P TP
Sbjct: 409 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 468
Query: 540 KWEEDSESSSEESSDSSDGEVPTAV---APAQEKSLGNI-LQAKPTSS--PAKGPPQKAG 593
+E S ++ +E + ++ PT AP KS + PT++ PA P++
Sbjct: 469 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 528
Query: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653
P + A + + + + PA T + P PKK T
Sbjct: 529 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP 588
Query: 654 AKVAPVRVGTQAPR----------KAGTATSPAGSSP----AVAGGTQRPAEDSSSSEES 699
K+AP AP + T T+P +P A A T + ++ E +
Sbjct: 589 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 648
Query: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 759
+ ++ A + KG P AP P K P K+
Sbjct: 649 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEP---------APTTPKKPAPKELAPTTTKE 699
Query: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
S + ++ + + +P K T + P + +A T+ P
Sbjct: 700 PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAP 758
Query: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA---QAQTGPEEDSGSSEEESD 876
K+ +P+ K P + + P+ K A A T PE ++ E S
Sbjct: 759 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 818
Query: 877 SEEEAE-TLAQVKPSGKTHQIRAALAP--AKESPRKGAAPT--PPGKTGPSAAQAGK 928
E T P T ++ A P + SP++ PT P T P K
Sbjct: 819 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 875
Score = 88.2 bits (217), Expect = 3e-17
Identities = 144/767 (18%), Positives = 258/767 (33%), Gaps = 67/767 (8%)
Query: 230 TKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKP----------------EEESESS 273
T ++KA P G + K PP K+ K +E S SS
Sbjct: 70 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSS 129
Query: 274 EEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333
S S + A+ ++ + K K TP PP V + +G
Sbjct: 130 SSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPP-----VVDEAGSG 184
Query: 334 KPEEDSESSSEESSDSE-EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392
D + ++ ++S ++ + + + AK + S +KE+
Sbjct: 185 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 244
Query: 393 KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ---------AKPSGKA------PQVR 437
Q ++ +S++E+ S E+ A+ AKP+ KA P +
Sbjct: 245 TKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 304
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
P +P++ A+ P T +E ++ + +E
Sbjct: 305 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA 364
Query: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW-EEDSESSSEESSDSS 556
K P P +T P + P P + P TP +E + ++ +E + ++
Sbjct: 365 PTTPKEP--APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT 422
Query: 557 DGE-VPTA--VAPAQEKSLGNILQAKPTSSPAKGP----PQKAGPVAV-QVKAEKPMDNS 608
E PT AP K KP + K P P++ P + P + +
Sbjct: 423 PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA 482
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
++ +S+ + E AP +A P P T P T A P + P K
Sbjct: 483 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP-K 541
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T+P +P T++PA ++ E + + ++T + + L
Sbjct: 542 EPAPTTPKEPAPTT---TKKPA-PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 597
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
P + + AP P + PT + A +++ + E A +P + + K
Sbjct: 598 KPAP-TTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 654
Query: 789 QAKANPAAARAPSAKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 844
A P + KG T+ P K+ +P+ K P +
Sbjct: 655 PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 714
Query: 845 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
+ P+ K A + P G++ + +E A T + KP+ K P
Sbjct: 715 GTAPTTPKEPAPTTPKEPAPTTPKGTA--PTTLKEPAPTTPK-KPAPKELAPTTTKGPTS 771
Query: 905 ESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
+ K APT P +T P+ K+ + + + + E P TS
Sbjct: 772 TTSDK-PAPTTPKETAPTTP---KEPAPTTPKKPAPTTPETPPPTTS 814
Score = 69.7 bits (169), Expect = 1e-11
Identities = 114/530 (21%), Positives = 184/530 (34%), Gaps = 49/530 (9%)
Query: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA------AAQVQVGKQE 472
+E P S KAP AS K + ++ P +KT + V + +
Sbjct: 64 AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQ 123
Query: 473 EDSRSSSEESDSD--REALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 530
E S SSS S S R+ ++ N+A + L K +VK K P
Sbjct: 124 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNK--------KNRTKKKPTPKP 175
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 590
P A G D + ++ ++S + +V T+ K + P S +K
Sbjct: 176 PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSL 235
Query: 591 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK---PALKIPQTKACPKK 647
E N ++S + + S + ++ AK P K+ K PK
Sbjct: 236 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV-LAKPTPKA 294
Query: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP-AVAGGTQRPAEDSSSSEESDSEEEKT 706
TT + + T K +T+P +P + P E + ++ +S K
Sbjct: 295 ETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 354
Query: 707 GLAVTVGQ-----AKSVGKGLQVKAASVPVKG--SLGQGTAPVLPGKTGPTVTQVKA--E 757
T + K + A K + + AP P K PT + A
Sbjct: 355 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 414
Query: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817
+E + ++ +E +P K K P + P A T P T
Sbjct: 415 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP-APTTPKEPAPTTT--- 470
Query: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--- 874
K+ SP+ K P S A + A T A T P+E S ++ +E
Sbjct: 471 --KEPSPTTPKEPAPTTTKS-------APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 521
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESP--RKGAAPTPPGKTGPS 922
+ +E A T + KP+ T + A P + +P K APT P + P+
Sbjct: 522 TTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 570
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 114 bits (286), Expect = 3e-25
Identities = 172/875 (19%), Positives = 301/875 (34%), Gaps = 121/875 (13%)
Query: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
+QTS G+++ +KT D TS+ + +AET P L +
Sbjct: 294 KQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT- 351
Query: 114 GADLPSSMKEKAKAE-------TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSAN 166
P++ KE A T K+ T P P T K+ +P + EP+
Sbjct: 352 ----PTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 407
Query: 167 TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDE-----TDVEGKPSVK-- 219
T PA +P + A ++ ++ + ++ + T E P+
Sbjct: 408 TP---------KEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 458
Query: 220 --PAQVKASSVSTKE----SPARKAAPAPGKVGDVTPQVKGGALP--PAKRAKKPEEESE 271
P K + +TKE +P A AP K TP+ P PA K +
Sbjct: 459 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 518
Query: 272 SSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGK---AGAVAS 328
E + + AP T+ + K A + P + +P PAP A
Sbjct: 519 PKEPAPTTTKSAPTTTKEPAPTTTK----SAPTTPKEPSPTTTKEPAPTTPKEPAPTTPK 574
Query: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR--KGA 386
+ P+E + ++ +E + + + PA + + T + A + P K +P +
Sbjct: 575 KPAPTTPKEPAPTTPKEPAPTTTKKPAPTT--PKEPAPTTPKETAPTTPKKLTPTTPEKL 632
Query: 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKES 446
AP P K P + A E+ ++ E + A A + K P PA +
Sbjct: 633 APTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT 692
Query: 447 PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDRE----------ALAAMNAAQ 496
P++ AP P++T P + ++ ++ + + +E + A
Sbjct: 693 PKE-PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAP 751
Query: 497 VKPLGKSPQV--KPASTMGMGPLG---KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEE 551
P G +P +PA T P KG P + P TP K E ++
Sbjct: 752 TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK-ELAPTTTKGP 810
Query: 552 SSDSSDGEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+S +SD PT AP K KP + + PP V+ ++P
Sbjct: 811 TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIH 870
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+S +ES+ +E P A+ + +P + +T A K TT + K
Sbjct: 871 KSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA--------------K 916
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T ++P + ++++++ E +E ++ A +
Sbjct: 917 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTES-------------------KITATT 957
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
V + Q T P T K + + ++ E + E A P
Sbjct: 958 TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKD-------- 1009
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
RA ++K T P K A + K P VR P+ + + +++P
Sbjct: 1010 ---------RATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMP 1060
Query: 849 SV---GKAVATAAQAQTGPEEDSGSSEEESDSEEE 880
+ + Q T P + S E + + E
Sbjct: 1061 ELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1095
Score = 102 bits (254), Expect = 2e-21
Identities = 166/915 (18%), Positives = 316/915 (34%), Gaps = 91/915 (9%)
Query: 58 ELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAE-----AETAKATPRLASTNSSV 112
EL +K K +++ + KK P E+ + + +T+ ST+ +
Sbjct: 193 ELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKI 252
Query: 113 LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSP----RKSAEPSANTT 168
A P + + ++ + +T ++ T +T + K ++ + T
Sbjct: 253 TTAK-PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 311
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
+ +T + P AKP + + T T + S P + +++
Sbjct: 312 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 371
Query: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
+ + ++ AP K TP+ P K+P + + ++E AP T+
Sbjct: 372 KSAPTTPKEPAPTTTKSAPTTPKE-----PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTK 426
Query: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 348
S ++ PA TP K A P A + P+E + ++ E +
Sbjct: 427 SAPTTPKE---------PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT 477
Query: 349 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAP--PGKTGPAVAKAQAGKR 406
+ +E PA A K + T + A + P + +P P+P P + P K+
Sbjct: 478 TPKE-PAPTA--PKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTT 534
Query: 407 EEDSQSSSEESDSEEEAPAQA---KPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
+E + ++++ + + + P+ +P+ P+ A + P K +P PAP PA
Sbjct: 535 KEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAP 594
Query: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGP 523
+ KP +P+ +PA T K P
Sbjct: 595 TTTK------------------------------KPAPTTPK-EPAPT-----TPKETAP 618
Query: 524 VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT-S 582
P K+ P TP E ++ E + E PT P + A T
Sbjct: 619 TTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPK 678
Query: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
PA P++ P + A + + + + + PA T + P P T
Sbjct: 679 EPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 738
Query: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA--EDSSSSEESD 700
P T A P P K T+P +P GT E + ++ +
Sbjct: 739 KEPTSTTCDKPAPTTPKGTAPTTP-KEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKP 797
Query: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
+ +E A + KG + P + + TAP P + PT + A
Sbjct: 798 APKE---------LAPTTTKGPTSTTSDKPAP-TTPKETAPTTPKEPAPTTPKKPA---P 844
Query: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
+ + + SE + + + T++ K+ ++ P + P+ K ++P +
Sbjct: 845 TTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKE----PGVPT 900
Query: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAV-ATAAQAQTGPEEDSGSSEEESDSEE 879
++P+ KP + R + P A + T E+ + S + ++
Sbjct: 901 TKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQV 960
Query: 880 EAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGKQDDSGSSSEE 938
+ T P T LAP + +K T K +A + +S +++ +
Sbjct: 961 TSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPK 1020
Query: 939 SDSDGEAPAAVTSAQ 953
+AP TS +
Sbjct: 1021 PQKPTKAPKKPTSTK 1035
Score = 99.8 bits (247), Expect = 1e-20
Identities = 166/837 (19%), Positives = 280/837 (33%), Gaps = 83/837 (9%)
Query: 148 VANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAG--QADSSSEDTSS 205
V N S S +K+ PS + + T + P K + S + S SE+ S
Sbjct: 107 VHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQES 166
Query: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
SS + +++ + +S + +E + +VK K+
Sbjct: 167 SSSSSSSSSSSTIRKIKSSKNSAANRELQKKL-------------KVKDNKKNRTKKKPT 213
Query: 266 PE----EESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRAASAPAKGTPGKGATPA 318
P+ +E+ S + + + P + +Q V S KI + + P P T
Sbjct: 214 PKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPIN-PRPSLPPNSDTSK 272
Query: 319 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL-----LQAKASGKTSQVGA 373
+ ++ + +E + ++ + S+D +E+T +AK AK TS+V A
Sbjct: 273 ---ETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLA 329
Query: 374 ASAPAKESPRKGAA---PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
P E+ KG A P P T P + K + S + +E AP K +
Sbjct: 330 KPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSA 389
Query: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ----VGKQEEDSRSSSEESDSDR 486
P+ A + + +P PAP PA + K+ + + +
Sbjct: 390 PTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPK 449
Query: 487 EALAAMNAAQVKPLGKSP---QVKPASTMGMGP---LGKGAGPVPPGKVGPATPSAQV-G 539
E K P +PA T P K P P + P TP
Sbjct: 450 EPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPT 509
Query: 540 KWEEDSESSSEESSDSSDGEVPTAV---APAQEKSLGNI-LQAKPTSS--PAKGPPQKAG 593
+E S ++ +E + ++ PT AP KS + PT++ PA P++
Sbjct: 510 TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPA 569
Query: 594 PVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653
P + A + + + + PA T + P PKK T
Sbjct: 570 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP 629
Query: 654 AKVAPVRVGTQAPR----------KAGTATSPAGSSP----AVAGGTQRPAEDSSSSEES 699
K+AP AP + T T+P +P A A T + ++ E +
Sbjct: 630 EKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPA 689
Query: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ 759
+ ++ A + KG P AP P K P K+
Sbjct: 690 PTTPKEPAPTTPKETAPTTPKGTAPTTLKEP---------APTTPKKPAPKELAPTTTKE 740
Query: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
S + ++ + + +P K T + P + +A T+ P
Sbjct: 741 PTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG-TAPTTLKEPAPTTPKKPAP 799
Query: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA---QAQTGPEEDSGSSEEESD 876
K+ +P+ K P + + P+ K A A T PE ++ E S
Sbjct: 800 KELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 859
Query: 877 SEEEAE-TLAQVKPSGKTHQIRAALAP--AKESPRKGAAPT--PPGKTGPSAAQAGK 928
E T P T ++ A P + SP++ PT P T P K
Sbjct: 860 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAK 916
Score = 88.2 bits (217), Expect = 3e-17
Identities = 144/767 (18%), Positives = 258/767 (33%), Gaps = 67/767 (8%)
Query: 230 TKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKP----------------EEESESS 273
T ++KA P G + K PP K+ K +E S SS
Sbjct: 111 TSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSS 170
Query: 274 EEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAG 333
S S + A+ ++ + K K TP PP V + +G
Sbjct: 171 SSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPP-----VVDEAGSG 225
Query: 334 KPEEDSESSSEESSDSE-EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392
D + ++ ++S ++ + + + AK + S +KE+
Sbjct: 226 LDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVE 285
Query: 393 KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ---------AKPSGKA------PQVR 437
Q ++ +S++E+ S E+ A+ AKP+ KA P +
Sbjct: 286 TKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALT 345
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
P +P++ A+ P T +E ++ + +E
Sbjct: 346 TPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPA 405
Query: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKW-EEDSESSSEESSDSS 556
K P P +T P + P P + P TP +E + ++ +E + ++
Sbjct: 406 PTTPKEP--APTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTT 463
Query: 557 DGE-VPTA--VAPAQEKSLGNILQAKPTSSPAKGP----PQKAGPVAV-QVKAEKPMDNS 608
E PT AP K KP + K P P++ P + P + +
Sbjct: 464 PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPA 523
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
++ +S+ + E AP +A P P T P T A P + P K
Sbjct: 524 PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP-K 582
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T+P +P T++PA ++ E + + ++T + + L
Sbjct: 583 EPAPTTPKEPAPTT---TKKPA-PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 638
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
P + + AP P + PT + A +++ + E A +P + + K
Sbjct: 639 KPAP-TTPEELAPTTPEEPTPTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEPAPTTPKE 695
Query: 789 QAKANPAAARAPSAKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 844
A P + KG T+ P K+ +P+ K P +
Sbjct: 696 PAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPK 755
Query: 845 ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
+ P+ K A + P G++ + +E A T + KP+ K P
Sbjct: 756 GTAPTTPKEPAPTTPKEPAPTTPKGTA--PTTLKEPAPTTPK-KPAPKELAPTTTKGPTS 812
Query: 905 ESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
+ K APT P +T P+ K+ + + + + E P TS
Sbjct: 813 TTSDK-PAPTTPKETAPTTP---KEPAPTTPKKPAPTTPETPPPTTS 855
Score = 69.7 bits (169), Expect = 1e-11
Identities = 114/530 (21%), Positives = 184/530 (34%), Gaps = 49/530 (9%)
Query: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA------AAQVQVGKQE 472
+E P S KAP AS K + ++ P +KT + V + +
Sbjct: 105 AEVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQ 164
Query: 473 EDSRSSSEESDSD--REALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG 530
E S SSS S S R+ ++ N+A + L K +VK K P
Sbjct: 165 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNK--------KNRTKKKPTPKP 216
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 590
P A G D + ++ ++S + +V T+ K + P S +K
Sbjct: 217 PVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSL 276
Query: 591 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK---PALKIPQTKACPKK 647
E N ++S + + S + ++ AK P K+ K PK
Sbjct: 277 TVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV-LAKPTPKA 335
Query: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSP-AVAGGTQRPAEDSSSSEESDSEEEKT 706
TT + + T K +T+P +P + P E + ++ +S K
Sbjct: 336 ETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKE 395
Query: 707 GLAVTVGQ-----AKSVGKGLQVKAASVPVKG--SLGQGTAPVLPGKTGPTVTQVKA--E 757
T + K + A K + + AP P K PT + A
Sbjct: 396 PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTT 455
Query: 758 KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAA 817
+E + ++ +E +P K K P + P A T P T
Sbjct: 456 PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEP-APTTPKEPAPTTT--- 511
Query: 818 QAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE--- 874
K+ SP+ K P S A + A T A T P+E S ++ +E
Sbjct: 512 --KEPSPTTPKEPAPTTTKS-------APTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAP 562
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKESP--RKGAAPTPPGKTGPS 922
+ +E A T + KP+ T + A P + +P K APT P + P+
Sbjct: 563 TTPKEPAPTTPK-KPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPT 611
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 102 bits (255), Expect = 1e-21
Identities = 168/731 (22%), Positives = 275/731 (37%), Gaps = 83/731 (11%)
Query: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
P+ PAQ S + E P KA P VG Q G A PP ++ P+ ++ +
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ--QP 425
Query: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
G +S +AP T++ V+ PG G PA G ++Q + G
Sbjct: 426 GLQSPAKAPGPTKTPVQ-----------------QPGPGKIPAQQAGPGKTSAQ-QTGPT 467
Query: 336 EEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPAKESPRKGAAPAPPGKT 394
+ S+ ++ PA Q A + Q G+ P ++ +P PG T
Sbjct: 468 KPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGST 527
Query: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
P + + K S ++ S + P SGK Q S AK+ P +G
Sbjct: 528 KPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGL--- 584
Query: 455 PPRKTGPA--AAQVQVGKQEEDSRSSSEESDSDREALAAMN----AAQVKP-LGKSPQVK 507
P+ P ++ + E+ + ++ E + +L N +VK L + Q+K
Sbjct: 585 -PKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMK 643
Query: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
A + P+ + P P K P T ++ V K S +++S D ++ A
Sbjct: 644 RALGGDLAPV--PSSPQPKLKTAPVTTTSAVSK----SSPQPQQTSPKKDAAPKQDLSKA 697
Query: 568 QEKSLGNILQAKPT-----SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
E L +PT S+ AK PP+ A ++ ++P SE ++ + AD +
Sbjct: 698 PEPKKPPPLVKQPTLHGSPSAKAKQPPE-ADSLSKPAPPKEPSVPSE--QDKAPVADDKP 754
Query: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-----SPAG 677
M KP + + + K + +S + T P K +A P G
Sbjct: 755 KQPKM----VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTG 810
Query: 678 S--SPAVAGGTQRPAEDSS-SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGS 734
SP + RPA DS S S E K V Q K K Q K + P
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKP 870
Query: 735 LGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE----------SDSEEAAASPAQVKTS 784
+ +G +P PG PT Q Q+ + E+ +D+ ++ + Q +T
Sbjct: 871 MPKG-SPTPPGPR-PTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQ-ETV 927
Query: 785 VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 844
K ++A + T PG +Q+ +P K P P S +GP
Sbjct: 928 TGKLFGFGASIFSQASNLISTAGQPG----PHSQSGPGAPMKQAPAPSQPPTS----QGP 979
Query: 845 ASVPSVGKA-VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
S G+A A A E + ++E+ E+A T+ + + K I+ + +
Sbjct: 980 PK--STGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLT 1037
Query: 904 KESPRKGAAPT 914
E P+K PT
Sbjct: 1038 AE-PQKAVLPT 1047
Score = 99.0 bits (245), Expect = 2e-20
Identities = 209/977 (21%), Positives = 339/977 (34%), Gaps = 146/977 (14%)
Query: 85 SESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP-- 142
S+ SEEE A L + A+ PS M K + ++ K P P
Sbjct: 46 SQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPS-MHRKQELDSSHPPKQSGRPPDPGR 104
Query: 143 ------ATGKTVANL-----LSGKSPRK-SAEPSANTTLVSETEEEGSVPAF-----GAA 185
+ +T L G+SP S + S + T + E + +P F +
Sbjct: 105 PAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALS 164
Query: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
A +V+ D+ +S +ET + K V+ Q K + + P P +
Sbjct: 165 AVSSVVNKFNPFDLISDSEASQEETTKKQKV-VQKEQGKPEGIIKPPLQQQPPKPIPKQQ 223
Query: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
G ++ P + +++PE+ +S G+ + P T A K+ R AS
Sbjct: 224 GPGRDPLQQDGTPKSISSQQPEK-IKSQPPGTGKPIQGPTQTPQTDHA--KLPLQRDASR 280
Query: 306 P----AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361
P A G+ P+ P + Q GKP + E+S + PA
Sbjct: 281 PQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQ-QPGHEKSQPGPAKPPA------ 333
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAPA-PPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Q + P + P P PPG T P A+ + Q+ SE+ SE
Sbjct: 334 --------QPSGLTKPLAQQPGTVKPPVQPPGTTKPP-AQPLGPAKPPAQQTGSEKPSSE 384
Query: 421 EEAP-AQAKPSGKAPQVRAASAPAKESPRKGAAP----------APPRKTGPAAAQVQ-- 467
+ P A A+P G PAK ++ P +P + GP VQ
Sbjct: 385 QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444
Query: 468 -----VGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG---PLGK 519
+Q ++S++++ + A+ P P P G
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP 504
Query: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ-- 577
G+ PP + GPA PS Q + S + S + P+ P+ ++S + Q
Sbjct: 505 GSTKPPPQQPGPAKPSPQ--QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562
Query: 578 -AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES-----SEESSDSADSEEAPAAMTAAQ 631
KP P P K P K P+ N+ E+++ + +E +
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG 622
Query: 632 AKPALKIPQTKA-----CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT 686
P + + K C K +APV Q K T+P ++ AV+ +
Sbjct: 623 FNPNPHLTEVKEWLCLNCQMK--RALGGDLAPVPSSPQPKLK----TAPVTTTSAVSKSS 676
Query: 687 QRPAEDSSSSEESDSEE---------------------EKTGLAVTVGQAKSVGKGLQVK 725
+P + S + + ++ + A +A S+ K K
Sbjct: 677 PQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPK 736
Query: 726 AASVPVKGSLGQGTAPVLPGK---------TGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
SVP + Q APV K T V+ A + D SS+ +S +EE
Sbjct: 737 EPSVPSE----QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTT 792
Query: 777 SP-----AQVKTSVKKTQAKANP----AAARAPSAKGTISAPGKVVTAAAQ------AKQ 821
P A+ S T K +P A R S IS PG + Q K+
Sbjct: 793 PPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852
Query: 822 RSPSKVKPPVRNPQNSTVLARG----PASVPSVGKAVATAAQAQTGPEED---SGSSEEE 874
P K + + ++ + +G P P+ G+ V T Q+ E+ S +
Sbjct: 853 EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAAL-APAKESPRKGAAPTPPGKTGPSA--AQAGKQDD 931
+D+ + T Q +GK A++ + A P P ++GP A QA
Sbjct: 913 TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972
Query: 932 SGSSSEESDSDGEAPAA 948
+S S G+AP A
Sbjct: 973 PPTSQGPPKSTGQAPPA 989
Score = 89.4 bits (220), Expect = 1e-17
Identities = 193/899 (21%), Positives = 311/899 (34%), Gaps = 112/899 (12%)
Query: 103 PRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMP-HPATGKTVANLLSGKSPRKSA 161
P S+ A PS K A+ T+ +TG+ P P T A + K+
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI 588
Query: 162 EPSANTT-LVSETEEEG-------------SVPAFGAAAKPGMVSAGQADSSSEDTSSSS 207
P NTT L+ E+ S+ F V + +
Sbjct: 589 CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 648
Query: 208 DETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
D V P K +K + V+T S K++P P + K A P +K PE
Sbjct: 649 DLAPVPSSPQPK---LKTAPVTTT-SAVSKSSPQPQQTSP-----KKDAAPKQDLSKAPE 699
Query: 268 EESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV- 326
+ + +P+ Q ++ + S PA P + + P+ KA
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSL------SKPAP--PKEPSVPSEQDKAPVAD 751
Query: 327 --ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384
Q K KP D SSS S+ ++ + P++K +Q++A KT+ P K K
Sbjct: 752 DKPKQPKMVKPTTDLVSSS--SATTKPDIPSSK--VQSQAEEKTTP------PLKTDSAK 801
Query: 385 GAAPAPPG--KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
+ PP K P +KA + S SE + Q P K + + A
Sbjct: 802 PSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT- 860
Query: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
K SP+ A P P P + G+ + S + + R ++N + K
Sbjct: 861 -KMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRF--SLNLGSITDAPK 917
Query: 503 SPQVKPASTMGMGPLGKGAG--------------PVPPGKVGPATPSAQVGKWEEDSESS 548
S P T+ G GA P P + GP P Q S+
Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQA---PAPSQPP 974
Query: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+ + S G+ P PA KS I K T +PA +K P A Q K +
Sbjct: 975 TSQGPPKSTGQAP----PAPAKS---IPVKKETKAPAA---EKLEPKAEQAPTVKRTETE 1024
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+ DS ++TA K L K+ PK +T K + +G++ P
Sbjct: 1025 KKPPPIKDSK-------SLTAEPQKAVLPTKLEKS-PKPESTCPLCKTE-LNIGSKDPPN 1075
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVK 725
T T + G P + + + ++ +G + + G +
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 726 AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE---ESDSEEAAAS--PAQ 780
VP + S + P P V VK ++QE +E+ E E + P
Sbjct: 1136 PMPVPTESSSQKTAVP-------PQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPM 1188
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRN----PQN 836
V T K+ ++K A A K + K++ + K RS K KP + P++
Sbjct: 1189 VTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPE--EEKIRSEEK-KPLLEEKKPTPED 1245
Query: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE-EEAETLAQVKPSGKTHQ 895
+L S P K +Q Q E+ G ++ E ++ +T + PSG
Sbjct: 1246 KKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQS 1305
Query: 896 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQD 954
+ ++ ++ P PP P + GK+ + S + P + D
Sbjct: 1306 LPKEDDKTTKTIKE--QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSD 1362
Score = 89.4 bits (220), Expect = 1e-17
Identities = 208/955 (21%), Positives = 327/955 (34%), Gaps = 173/955 (18%)
Query: 113 LGADL---PSSMKEKAK-AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
LG DL PSS + K K A S P P + + K+ EP
Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV-EGKPS----VKPAQ 222
LV + GS P+ A P S + A S D+ V + KP VKP
Sbjct: 706 LVKQPTLHGS-PSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTT 764
Query: 223 --VKASSVSTK--------ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
V +SS +TK +S A + P K P + PP P +
Sbjct: 765 DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQ---SFPPTGEKVSPFDSKAI 821
Query: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT----------PGKGATPAPPGK 322
S+S+ + G S+ K +++ V+ P K P +P PPG
Sbjct: 822 PRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGP 881
Query: 323 ---AG-AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS-AP 377
AG V + ++ KP+E S S + + Q +GK GA+ +
Sbjct: 882 RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941
Query: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
A P P ++GP QA + S K +G+AP
Sbjct: 942 ASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-----------KSTGQAPPAP 990
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
A S P K+ + AA K P A Q K+ E + DS A
Sbjct: 991 AKSIPVKKETKAPAA----EKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP 1046
Query: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT-------------PSAQVGKWEE- 543
L KSP KP ST + G P T P+ + + +E
Sbjct: 1047 TKLEKSP--KPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 544 -DSESSSEESSDSSDGEV-PTAVAPAQEKSLGNILQAKPTSSPAKGPPQ----KAGPVAV 597
++ + G++ AP+ K+ + + +S PPQ K V
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP--KKTNTTASAK 655
+ +AEK + E+ ++ E+ P +T Q + K+ + KA +K K
Sbjct: 1165 KTEAEKVI-----LEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219
Query: 656 VAP----VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE---DSSSSEESDSEEEKTGL 708
+ P +R + P +P T P E D S+ +EE+ G
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279
Query: 709 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 768
+ GK Q K +P GT LP + T +K + Q
Sbjct: 1280 VAP--KTVQEGKQPQTKMEGLP------SGTPQSLPKEDDKTTKTIKEQPQPP------- 1324
Query: 769 SDSEEAAASPAQVKTSVKKTQA---KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
A P QV+ +KT+ K++ ++++ P + +S G + + PS
Sbjct: 1325 -----CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPS 1379
Query: 826 KVKPPVRN---------------PQNSTVLARGPASVPSVGKAVATA-----AQAQTGPE 865
+ ++ P + + LA+ ++V S+ +A A+ ++ +T P
Sbjct: 1380 LIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPH 1439
Query: 866 EDSG--------------------SSEEESDSEEEAETL-----AQVKPSGKTHQIRAAL 900
E S S EE +S+EE + Q PS K H+ ++
Sbjct: 1440 EVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEF 1499
Query: 901 AP-----------AKESPRKGAAPTPPGK----TGPSAAQAGKQDDSGSSSEESD 940
+ES +P P K G S++ KQ+DS S EE D
Sbjct: 1500 VDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEED 1554
Score = 60.8 bits (146), Expect = 6e-09
Identities = 136/686 (19%), Positives = 236/686 (34%), Gaps = 100/686 (14%)
Query: 73 AKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMK-EKAKAETEK 131
++KT V + + E+E + EAE + + + + + K E++K E +K
Sbjct: 1145 SQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDK 1204
Query: 132 AGKTGNSMPHPATGKTVAN-----------LLSGKSPR---KSAEPSANTTLVSETEEE- 176
A P P K + LL K P K P A T+ E + +
Sbjct: 1205 ASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDL 1264
Query: 177 -GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV-KASSVSTKESP 234
S G V+ + +T +EG PS P + K +TK
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQP------QTKMEGLPSGTPQSLPKEDDKTTKTIK 1318
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
+ P K V P +K E+E + S+ S + ++P G +S
Sbjct: 1319 EQPQPPCTAKPDQVEPG-----------KEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSS 1367
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
+ I + G+ + P + + K +E S SS + + E
Sbjct: 1368 DGI----------SSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLES--- 1414
Query: 355 AAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
++L+A+AS + P + SP + P KT + EE+ + S
Sbjct: 1415 TVLSILEAQASTLADEKSEKKTQPHEVSPEQ---PKDQEKTQSLSETLEITISEEEIKES 1471
Query: 414 SEE------SDSEEEAPAQAKPSGKAPQV------RAASAPAKESPRKGAAPAPPRKTGP 461
EE DS+++ P+ K+ V R +ES +P P RK
Sbjct: 1472 QEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRT 1531
Query: 462 AAAQVQVGK-QEEDSRSSSEESDSDREALAAMNA--------------AQVKPLGKSPQ- 505
+ + ++EDS+ S EE D R+ + M+A Q+K + S +
Sbjct: 1532 SVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTES 1591
Query: 506 VKPASTMGMGPL--GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTA 563
K T G G + GK + + W ++ + + +ES + E +
Sbjct: 1592 QKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQ 1651
Query: 564 VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA-----EKPMDNSESSEESSDSA 618
+ + G L+ T K + Q K E+P ES +S +
Sbjct: 1652 ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDR 1711
Query: 619 DSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS 678
E +++ A+ P + + ++++ S K + +A + P
Sbjct: 1712 SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPT-- 1769
Query: 679 SPAVAGGTQRPAEDSSSSEESDSEEE 704
EDSS EE EEE
Sbjct: 1770 -----------IEDSSEEEELREEEE 1784
Score = 52.0 bits (123), Expect = 3e-06
Identities = 133/656 (20%), Positives = 228/656 (34%), Gaps = 108/656 (16%)
Query: 79 SDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNS 138
S P ++ + +A AK+ P T + P++ K + KAE K +
Sbjct: 971 SQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA-------PAAEKLEPKAEQAPTVKRTET 1023
Query: 139 MPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS 198
P K +L + P+K+ P T L + E + P G ++
Sbjct: 1024 EKKPPPIKDSKSLTA--EPQKAVLP---TKLEKSPKPESTCPLCKTELNIGSKDPPNFNT 1078
Query: 199 SSEDTSSSSDETDVEGKPSVKPAQV-------KASSVSTKESPARKAAPAPG-------K 244
+E + + P + Q ++S + RK PAP
Sbjct: 1079 CTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMP 1138
Query: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
V + K P K KK E+E ++ E E+ + + EKI
Sbjct: 1139 VPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKV------KETLSMEKI------- 1185
Query: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 364
P T + + K A A Q K PEE EE SEE+ P LL+ K
Sbjct: 1186 -PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKP----LLEEK- 1239
Query: 365 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
P P K AK A + ++ S+ +EE+
Sbjct: 1240 ----------------------KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLE 1277
Query: 425 AQAKP----SGKAPQVRAASAPA-----------KESPRKGAAPAPPRKTGPAAAQVQVG 469
+ P GK PQ + P+ K + P PP P QV+ G
Sbjct: 1278 GRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPG 1335
Query: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV 529
K++ + ++ S ++ KSPQ + + G +P +
Sbjct: 1336 KEKTEKEDDKSDTSSSQQP-------------KSPQGLSDTGYSSDGISSSLGEIP--SL 1380
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
P + ++D S S+ESS SS ++ E ++ +IL+A+ ++ +
Sbjct: 1381 IPTDEKDILKGLKKD--SFSQESSPSSPSDLAKL-----ESTVLSILEAQASTLADEKSE 1433
Query: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
+K P V + K + ++S E+ + SEE + + K K + P +
Sbjct: 1434 KKTQPHEVSPEQPKDQEKTQSLSETLEITISEE-EIKESQEERKDTFKKDSQQDIPSSKD 1492
Query: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
++ + P + +S + +SP V +R + SSSS+E E+ +
Sbjct: 1493 HKEKSEFVDDITTRREPYDSVEESSESENSP-VPQRKRRTSVGSSSSDEYKQEDSQ 1547
Score = 32.3 bits (72), Expect = 2.2
Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 19/288 (6%)
Query: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG--KAPQVR 437
+ P + A GK G ++ +A K + S+ SS + E Q +P G + P +R
Sbjct: 3483 DMPTRSRRKARVGKYGDSM--TEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIR 3540
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
A E + +AP K G Q E DS + S + S
Sbjct: 3541 ARVDAKVEIIKHISAPEKTYKGGSLGCQT-----EADSDTQSPQYLSATSPPKDKKRPTP 3595
Query: 498 KPLGKSPQVKPASTMGMGPLGKGA-----GPVPPGKVGPATPSAQVGKWEEDSESSSEES 552
+G S ++ ST+ + P + P+ P G A SA V + + S +
Sbjct: 3596 LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQK 3655
Query: 553 SDSSD-GEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
D +VP A A ++S+ + PT+ + P + K + M +S
Sbjct: 3656 VLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQY-TEGYTTKGSQTMTSS 3714
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV 656
+ ++ + + T Q+ + ++ +TNT A AK+
Sbjct: 3715 GAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKI 3762
Score = 30.4 bits (67), Expect = 8.3
Identities = 85/414 (20%), Positives = 152/414 (36%), Gaps = 45/414 (10%)
Query: 5 RKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRK 64
+K+ E L + HLL R+ + Q+ Q + L I QQ + ++K
Sbjct: 3254 QKKLEELQSMKQHLLFQQ--EEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQK 3311
Query: 65 AEEDAALQAKKTRVSDPISTSESSEEEEE---AEAETAKATPRLASTNSSVLGADLPSSM 121
+ + + P +T+E + E + E AT +T S+V+ ++P S
Sbjct: 3312 IRQIYQYNYDPSGTASPQTTTEQAILEGQYAALEGSQFWATEDATTTASAVVAIEIPQS- 3370
Query: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANL----LSGKSPRKSAEPSANTTLVSETEEEG 177
+ + G T P P TV+ + + K ++ + S+ + + ++ G
Sbjct: 3371 --QGWYTVQSDGVTQYIAP-PGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDDMG 3427
Query: 178 SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPA-QVKASSVSTKESPAR 236
+ +V +G + T S K SV + Q + P R
Sbjct: 3428 ENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTR 3487
Query: 237 KAAPAP-GKVGDVTPQVKGGALPPAKRAKKPEEESESSEE--GSESEEEAPAGT------ 287
A GK GD ++ A + K + S + + S + P GT
Sbjct: 3488 SRRKARVGKYGD--------SMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSI 3539
Query: 288 RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS 347
R++V A +I ++ SAP K G G++ QT+A + + S S
Sbjct: 3540 RARVDAKVEI--IKHISAPEKTYKG-----------GSLGCQTEADSDTQSPQYLSATSP 3586
Query: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
+++ P + + S V A +P K SP+ +P P G A+ A
Sbjct: 3587 PKDKKRPTPLEIGYSSHLRADSTVQLAPSPPK-SPKVLYSPISPLSPGKALESA 3639
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 102 bits (255), Expect = 1e-21
Identities = 168/731 (22%), Positives = 275/731 (37%), Gaps = 83/731 (11%)
Query: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
P+ PAQ S + E P KA P VG Q G A PP ++ P+ ++ +
Sbjct: 368 PAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQ--QP 425
Query: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
G +S +AP T++ V+ PG G PA G ++Q + G
Sbjct: 426 GLQSPAKAPGPTKTPVQ-----------------QPGPGKIPAQQAGPGKTSAQ-QTGPT 467
Query: 336 EEDSESSSEESSDSEEETPAAKALLQ-AKASGKTSQVGAASAPAKESPRKGAAPAPPGKT 394
+ S+ ++ PA Q A + Q G+ P ++ +P PG T
Sbjct: 468 KPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGST 527
Query: 395 GPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA 454
P + + K S ++ S + P SGK Q S AK+ P +G
Sbjct: 528 KPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGL--- 584
Query: 455 PPRKTGPA--AAQVQVGKQEEDSRSSSEESDSDREALAAMN----AAQVKP-LGKSPQVK 507
P+ P ++ + E+ + ++ E + +L N +VK L + Q+K
Sbjct: 585 -PKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMK 643
Query: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
A + P+ + P P K P T ++ V K S +++S D ++ A
Sbjct: 644 RALGGDLAPV--PSSPQPKLKTAPVTTTSAVSK----SSPQPQQTSPKKDAAPKQDLSKA 697
Query: 568 QEKSLGNILQAKPT-----SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
E L +PT S+ AK PP+ A ++ ++P SE ++ + AD +
Sbjct: 698 PEPKKPPPLVKQPTLHGSPSAKAKQPPE-ADSLSKPAPPKEPSVPSE--QDKAPVADDKP 754
Query: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-----SPAG 677
M KP + + + K + +S + T P K +A P G
Sbjct: 755 KQPKM----VKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTG 810
Query: 678 S--SPAVAGGTQRPAEDSS-SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGS 734
SP + RPA DS S S E K V Q K K Q K + P
Sbjct: 811 EKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKP 870
Query: 735 LGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE----------SDSEEAAASPAQVKTS 784
+ +G +P PG PT Q Q+ + E+ +D+ ++ + Q +T
Sbjct: 871 MPKG-SPTPPGPR-PTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQ-ETV 927
Query: 785 VKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 844
K ++A + T PG +Q+ +P K P P S +GP
Sbjct: 928 TGKLFGFGASIFSQASNLISTAGQPG----PHSQSGPGAPMKQAPAPSQPPTS----QGP 979
Query: 845 ASVPSVGKA-VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
S G+A A A E + ++E+ E+A T+ + + K I+ + +
Sbjct: 980 PK--STGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLT 1037
Query: 904 KESPRKGAAPT 914
E P+K PT
Sbjct: 1038 AE-PQKAVLPT 1047
Score = 99.0 bits (245), Expect = 2e-20
Identities = 209/977 (21%), Positives = 339/977 (34%), Gaps = 146/977 (14%)
Query: 85 SESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP-- 142
S+ SEEE A L + A+ PS M K + ++ K P P
Sbjct: 46 SQLSEEERRQIAAVMSRAQGLPKGSVPPAAAESPS-MHRKQELDSSHPPKQSGRPPDPGR 104
Query: 143 ------ATGKTVANL-----LSGKSPRK-SAEPSANTTLVSETEEEGSVPAF-----GAA 185
+ +T L G+SP S + S + T + E + +P F +
Sbjct: 105 PAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALS 164
Query: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
A +V+ D+ +S +ET + K V+ Q K + + P P +
Sbjct: 165 AVSSVVNKFNPFDLISDSEASQEETTKKQKV-VQKEQGKPEGIIKPPLQQQPPKPIPKQQ 223
Query: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
G ++ P + +++PE+ +S G+ + P T A K+ R AS
Sbjct: 224 GPGRDPLQQDGTPKSISSQQPEK-IKSQPPGTGKPIQGPTQTPQTDHA--KLPLQRDASR 280
Query: 306 P----AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361
P A G+ P+ P + Q GKP + E+S + PA
Sbjct: 281 PQTKQADIVRGESVKPSLPSPSKPPIQQPTPGKPPAQ-QPGHEKSQPGPAKPPA------ 333
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAPA-PPGKTGPAVAKAQAGKREEDSQSSSEESDSE 420
Q + P + P P PPG T P A+ + Q+ SE+ SE
Sbjct: 334 --------QPSGLTKPLAQQPGTVKPPVQPPGTTKPP-AQPLGPAKPPAQQTGSEKPSSE 384
Query: 421 EEAP-AQAKPSGKAPQVRAASAPAKESPRKGAAP----------APPRKTGPAAAQVQ-- 467
+ P A A+P G PAK ++ P +P + GP VQ
Sbjct: 385 QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444
Query: 468 -----VGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG---PLGK 519
+Q ++S++++ + A+ P P P G
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP 504
Query: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ-- 577
G+ PP + GPA PS Q + S + S + P+ P+ ++S + Q
Sbjct: 505 GSTKPPPQQPGPAKPSPQ--QPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTG 562
Query: 578 -AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES-----SEESSDSADSEEAPAAMTAAQ 631
KP P P K P K P+ N+ E+++ + +E +
Sbjct: 563 SGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCG 622
Query: 632 AKPALKIPQTKA-----CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT 686
P + + K C K +APV Q K T+P ++ AV+ +
Sbjct: 623 FNPNPHLTEVKEWLCLNCQMK--RALGGDLAPVPSSPQPKLK----TAPVTTTSAVSKSS 676
Query: 687 QRPAEDSSSSEESDSEE---------------------EKTGLAVTVGQAKSVGKGLQVK 725
+P + S + + ++ + A +A S+ K K
Sbjct: 677 PQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPK 736
Query: 726 AASVPVKGSLGQGTAPVLPGK---------TGPTVTQVKAEKQEDSESSEEESDSEEAAA 776
SVP + Q APV K T V+ A + D SS+ +S +EE
Sbjct: 737 EPSVPSE----QDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTT 792
Query: 777 SP-----AQVKTSVKKTQAKANP----AAARAPSAKGTISAPGKVVTAAAQ------AKQ 821
P A+ S T K +P A R S IS PG + Q K+
Sbjct: 793 PPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKK 852
Query: 822 RSPSKVKPPVRNPQNSTVLARG----PASVPSVGKAVATAAQAQTGPEED---SGSSEEE 874
P K + + ++ + +G P P+ G+ V T Q+ E+ S +
Sbjct: 853 EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSI 912
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAAL-APAKESPRKGAAPTPPGKTGPSA--AQAGKQDD 931
+D+ + T Q +GK A++ + A P P ++GP A QA
Sbjct: 913 TDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQ 972
Query: 932 SGSSSEESDSDGEAPAA 948
+S S G+AP A
Sbjct: 973 PPTSQGPPKSTGQAPPA 989
Score = 89.4 bits (220), Expect = 1e-17
Identities = 193/899 (21%), Positives = 311/899 (34%), Gaps = 112/899 (12%)
Query: 103 PRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMP-HPATGKTVANLLSGKSPRKSA 161
P S+ A PS K A+ T+ +TG+ P P T A + K+
Sbjct: 529 PPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTI 588
Query: 162 EPSANTT-LVSETEEEG-------------SVPAFGAAAKPGMVSAGQADSSSEDTSSSS 207
P NTT L+ E+ S+ F V + +
Sbjct: 589 CPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGG 648
Query: 208 DETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPE 267
D V P K +K + V+T S K++P P + K A P +K PE
Sbjct: 649 DLAPVPSSPQPK---LKTAPVTTT-SAVSKSSPQPQQTSP-----KKDAAPKQDLSKAPE 699
Query: 268 EESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAV- 326
+ + +P+ Q ++ + S PA P + + P+ KA
Sbjct: 700 PKKPPPLVKQPTLHGSPSAKAKQPPEADSL------SKPAP--PKEPSVPSEQDKAPVAD 751
Query: 327 --ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRK 384
Q K KP D SSS S+ ++ + P++K +Q++A KT+ P K K
Sbjct: 752 DKPKQPKMVKPTTDLVSSS--SATTKPDIPSSK--VQSQAEEKTTP------PLKTDSAK 801
Query: 385 GAAPAPPG--KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
+ PP K P +KA + S SE + Q P K + + A
Sbjct: 802 PSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQT- 860
Query: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
K SP+ A P P P + G+ + S + + R ++N + K
Sbjct: 861 -KMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRF--SLNLGSITDAPK 917
Query: 503 SPQVKPASTMGMGPLGKGAG--------------PVPPGKVGPATPSAQVGKWEEDSESS 548
S P T+ G GA P P + GP P Q S+
Sbjct: 918 SQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQA---PAPSQPP 974
Query: 549 SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
+ + S G+ P PA KS I K T +PA +K P A Q K +
Sbjct: 975 TSQGPPKSTGQAP----PAPAKS---IPVKKETKAPAA---EKLEPKAEQAPTVKRTETE 1024
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
+ DS ++TA K L K+ PK +T K + +G++ P
Sbjct: 1025 KKPPPIKDSK-------SLTAEPQKAVLPTKLEKS-PKPESTCPLCKTE-LNIGSKDPPN 1075
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG---KGLQVK 725
T T + G P + + + ++ +G + + G +
Sbjct: 1076 FNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKAS 1135
Query: 726 AASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE---ESDSEEAAAS--PAQ 780
VP + S + P P V VK ++QE +E+ E E + P
Sbjct: 1136 PMPVPTESSSQKTAVP-------PQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPM 1188
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRN----PQN 836
V T K+ ++K A A K + K++ + K RS K KP + P++
Sbjct: 1189 VTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPE--EEKIRSEEK-KPLLEEKKPTPED 1245
Query: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE-EEAETLAQVKPSGKTHQ 895
+L S P K +Q Q E+ G ++ E ++ +T + PSG
Sbjct: 1246 KKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQS 1305
Query: 896 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQD 954
+ ++ ++ P PP P + GK+ + S + P + D
Sbjct: 1306 LPKEDDKTTKTIKE--QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSD 1362
Score = 89.4 bits (220), Expect = 1e-17
Identities = 208/955 (21%), Positives = 327/955 (34%), Gaps = 173/955 (18%)
Query: 113 LGADL---PSSMKEKAK-AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
LG DL PSS + K K A S P P + + K+ EP
Sbjct: 646 LGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPP 705
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQ-ADSSSEDTSSSSDETDV-EGKPS----VKPAQ 222
LV + GS P+ A P S + A S D+ V + KP VKP
Sbjct: 706 LVKQPTLHGS-PSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTT 764
Query: 223 --VKASSVSTK--------ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
V +SS +TK +S A + P K P + PP P +
Sbjct: 765 DLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSAKPSQ---SFPPTGEKVSPFDSKAI 821
Query: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGT----------PGKGATPAPPGK 322
S+S+ + G S+ K +++ V+ P K P +P PPG
Sbjct: 822 PRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGP 881
Query: 323 ---AG-AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS-AP 377
AG V + ++ KP+E S S + + Q +GK GA+ +
Sbjct: 882 RPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQ 941
Query: 378 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVR 437
A P P ++GP QA + S K +G+AP
Sbjct: 942 ASNLISTAGQPGPHSQSGPGAPMKQAPAPSQPPTSQGPP-----------KSTGQAPPAP 990
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
A S P K+ + AA K P A Q K+ E + DS A
Sbjct: 991 AKSIPVKKETKAPAA----EKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLP 1046
Query: 498 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT-------------PSAQVGKWEE- 543
L KSP KP ST + G P T P+ + + +E
Sbjct: 1047 TKLEKSP--KPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEW 1104
Query: 544 -DSESSSEESSDSSDGEV-PTAVAPAQEKSLGNILQAKPTSSPAKGPPQ----KAGPVAV 597
++ + G++ AP+ K+ + + +S PPQ K V
Sbjct: 1105 LCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQEQEV 1164
Query: 598 QVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP--KKTNTTASAK 655
+ +AEK + E+ ++ E+ P +T Q + K+ + KA +K K
Sbjct: 1165 KTEAEKVI-----LEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKK 1219
Query: 656 VAP----VRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAE---DSSSSEESDSEEEKTGL 708
+ P +R + P +P T P E D S+ +EE+ G
Sbjct: 1220 LIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGR 1279
Query: 709 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEE 768
+ GK Q K +P GT LP + T +K + Q
Sbjct: 1280 VAP--KTVQEGKQPQTKMEGLP------SGTPQSLPKEDDKTTKTIKEQPQPP------- 1324
Query: 769 SDSEEAAASPAQVKTSVKKTQA---KANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
A P QV+ +KT+ K++ ++++ P + +S G + + PS
Sbjct: 1325 -----CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPS 1379
Query: 826 KVKPPVRN---------------PQNSTVLARGPASVPSVGKAVATA-----AQAQTGPE 865
+ ++ P + + LA+ ++V S+ +A A+ ++ +T P
Sbjct: 1380 LIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPH 1439
Query: 866 EDSG--------------------SSEEESDSEEEAETL-----AQVKPSGKTHQIRAAL 900
E S S EE +S+EE + Q PS K H+ ++
Sbjct: 1440 EVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEF 1499
Query: 901 AP-----------AKESPRKGAAPTPPGK----TGPSAAQAGKQDDSGSSSEESD 940
+ES +P P K G S++ KQ+DS S EE D
Sbjct: 1500 VDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSGEEED 1554
Score = 60.8 bits (146), Expect = 6e-09
Identities = 136/686 (19%), Positives = 236/686 (34%), Gaps = 100/686 (14%)
Query: 73 AKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMK-EKAKAETEK 131
++KT V + + E+E + EAE + + + + + K E++K E +K
Sbjct: 1145 SQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDK 1204
Query: 132 AGKTGNSMPHPATGKTVAN-----------LLSGKSPR---KSAEPSANTTLVSETEEE- 176
A P P K + LL K P K P A T+ E + +
Sbjct: 1205 ASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDL 1264
Query: 177 -GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV-KASSVSTKESP 234
S G V+ + +T +EG PS P + K +TK
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQP------QTKMEGLPSGTPQSLPKEDDKTTKTIK 1318
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
+ P K V P +K E+E + S+ S + ++P G +S
Sbjct: 1319 EQPQPPCTAKPDQVEPG-----------KEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSS 1367
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
+ I + G+ + P + + K +E S SS + + E
Sbjct: 1368 DGI----------SSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLES--- 1414
Query: 355 AAKALLQAKASGKTSQVGAASA-PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
++L+A+AS + P + SP + P KT + EE+ + S
Sbjct: 1415 TVLSILEAQASTLADEKSEKKTQPHEVSPEQ---PKDQEKTQSLSETLEITISEEEIKES 1471
Query: 414 SEE------SDSEEEAPAQAKPSGKAPQV------RAASAPAKESPRKGAAPAPPRKTGP 461
EE DS+++ P+ K+ V R +ES +P P RK
Sbjct: 1472 QEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRT 1531
Query: 462 AAAQVQVGK-QEEDSRSSSEESDSDREALAAMNA--------------AQVKPLGKSPQ- 505
+ + ++EDS+ S EE D R+ + M+A Q+K + S +
Sbjct: 1532 SVGSSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTES 1591
Query: 506 VKPASTMGMGPL--GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTA 563
K T G G + GK + + W ++ + + +ES + E +
Sbjct: 1592 QKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQ 1651
Query: 564 VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA-----EKPMDNSESSEESSDSA 618
+ + G L+ T K + Q K E+P ES +S +
Sbjct: 1652 ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDR 1711
Query: 619 DSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGS 678
E +++ A+ P + + ++++ S K + +A + P
Sbjct: 1712 SRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPT-- 1769
Query: 679 SPAVAGGTQRPAEDSSSSEESDSEEE 704
EDSS EE EEE
Sbjct: 1770 -----------IEDSSEEEELREEEE 1784
Score = 52.0 bits (123), Expect = 3e-06
Identities = 133/656 (20%), Positives = 228/656 (34%), Gaps = 108/656 (16%)
Query: 79 SDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNS 138
S P ++ + +A AK+ P T + P++ K + KAE K +
Sbjct: 971 SQPPTSQGPPKSTGQAPPAPAKSIPVKKETKA-------PAAEKLEPKAEQAPTVKRTET 1023
Query: 139 MPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS 198
P K +L + P+K+ P T L + E + P G ++
Sbjct: 1024 EKKPPPIKDSKSLTA--EPQKAVLP---TKLEKSPKPESTCPLCKTELNIGSKDPPNFNT 1078
Query: 199 SSEDTSSSSDETDVEGKPSVKPAQV-------KASSVSTKESPARKAAPAPG-------K 244
+E + + P + Q ++S + RK PAP
Sbjct: 1079 CTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMP 1138
Query: 245 VGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
V + K P K KK E+E ++ E E+ + + EKI
Sbjct: 1139 VPTESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKV------KETLSMEKI------- 1185
Query: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 364
P T + + K A A Q K PEE EE SEE+ P LL+ K
Sbjct: 1186 -PPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKP----LLEEK- 1239
Query: 365 SGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAP 424
P P K AK A + ++ S+ +EE+
Sbjct: 1240 ----------------------KPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLE 1277
Query: 425 AQAKP----SGKAPQVRAASAPA-----------KESPRKGAAPAPPRKTGPAAAQVQVG 469
+ P GK PQ + P+ K + P PP P QV+ G
Sbjct: 1278 GRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPPCTAKP--DQVEPG 1335
Query: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV 529
K++ + ++ S ++ KSPQ + + G +P +
Sbjct: 1336 KEKTEKEDDKSDTSSSQQP-------------KSPQGLSDTGYSSDGISSSLGEIP--SL 1380
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP 589
P + ++D S S+ESS SS ++ E ++ +IL+A+ ++ +
Sbjct: 1381 IPTDEKDILKGLKKD--SFSQESSPSSPSDLAKL-----ESTVLSILEAQASTLADEKSE 1433
Query: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
+K P V + K + ++S E+ + SEE + + K K + P +
Sbjct: 1434 KKTQPHEVSPEQPKDQEKTQSLSETLEITISEE-EIKESQEERKDTFKKDSQQDIPSSKD 1492
Query: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
++ + P + +S + +SP V +R + SSSS+E E+ +
Sbjct: 1493 HKEKSEFVDDITTRREPYDSVEESSESENSP-VPQRKRRTSVGSSSSDEYKQEDSQ 1547
Score = 32.3 bits (72), Expect = 2.2
Identities = 61/288 (21%), Positives = 107/288 (37%), Gaps = 19/288 (6%)
Query: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG--KAPQVR 437
+ P + A GK G ++ +A K + S+ SS + E Q +P G + P +R
Sbjct: 3483 DMPTRSRRKARVGKYGDSM--TEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSIR 3540
Query: 438 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 497
A E + +AP K G Q E DS + S + S
Sbjct: 3541 ARVDAKVEIIKHISAPEKTYKGGSLGCQT-----EADSDTQSPQYLSATSPPKDKKRPTP 3595
Query: 498 KPLGKSPQVKPASTMGMGPLGKGA-----GPVPPGKVGPATPSAQVGKWEEDSESSSEES 552
+G S ++ ST+ + P + P+ P G A SA V + + S +
Sbjct: 3596 LEIGYSSHLRADSTVQLAPSPPKSPKVLYSPISPLSPGKALESAFVPYEKPLPDDISPQK 3655
Query: 553 SDSSD-GEVPTA---VAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608
D +VP A A ++S+ + PT+ + P + K + M +S
Sbjct: 3656 VLHPDMAKVPPASPKTAKMMQRSMSDPKPLSPTADESSRAPFQY-TEGYTTKGSQTMTSS 3714
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV 656
+ ++ + + T Q+ + ++ +TNT A AK+
Sbjct: 3715 GAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKI 3762
Score = 30.4 bits (67), Expect = 8.3
Identities = 85/414 (20%), Positives = 152/414 (36%), Gaps = 45/414 (10%)
Query: 5 RKRRELLPLIYHHLLRAGYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRK 64
+K+ E L + HLL R+ + Q+ Q + L I QQ + ++K
Sbjct: 3254 QKKLEELQSMKQHLLFQQ--EEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQK 3311
Query: 65 AEEDAALQAKKTRVSDPISTSESSEEEEE---AEAETAKATPRLASTNSSVLGADLPSSM 121
+ + + P +T+E + E + E AT +T S+V+ ++P S
Sbjct: 3312 IRQIYQYNYDPSGTASPQTTTEQAILEGQYAALEGSQFWATEDATTTASAVVAIEIPQS- 3370
Query: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANL----LSGKSPRKSAEPSANTTLVSETEEEG 177
+ + G T P P TV+ + + K ++ + S+ + + ++ G
Sbjct: 3371 --QGWYTVQSDGVTQYIAP-PGILSTVSEIPLTDVVVKEEKQPKKRSSGAKVRGQYDDMG 3427
Query: 178 SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPA-QVKASSVSTKESPAR 236
+ +V +G + T S K SV + Q + P R
Sbjct: 3428 ENMTDDPRSFKKIVDSGVQTDDEDATDRSYVSRRRRTKKSVDTSVQTDDEDQDEWDMPTR 3487
Query: 237 KAAPAP-GKVGDVTPQVKGGALPPAKRAKKPEEESESSEE--GSESEEEAPAGT------ 287
A GK GD ++ A + K + S + + S + P GT
Sbjct: 3488 SRRKARVGKYGD--------SMTEADKTKPLSKVSSIAVQTVAEISVQTEPVGTIRTPSI 3539
Query: 288 RSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESS 347
R++V A +I ++ SAP K G G++ QT+A + + S S
Sbjct: 3540 RARVDAKVEI--IKHISAPEKTYKG-----------GSLGCQTEADSDTQSPQYLSATSP 3586
Query: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA 401
+++ P + + S V A +P K SP+ +P P G A+ A
Sbjct: 3587 PKDKKRPTPLEIGYSSHLRADSTVQLAPSPPK-SPKVLYSPISPLSPGKALESA 3639
Score = 30.4 bits (67), Expect = 8.3
Identities = 30/122 (24%), Positives = 40/122 (32%), Gaps = 15/122 (12%)
Query: 744 PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK 803
P K T K+ S S E S +Q KTSV +T + AA
Sbjct: 4863 PSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHLEDAGAA------- 4915
Query: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863
+ A A +Q KPP P S+V S G +V + + T
Sbjct: 4916 --------IAAAEAAVQQLRIQPTKPPNHRPAESSVSTGSSGSSFGSGYSVDSEGSSSTA 4967
Query: 864 PE 865
E
Sbjct: 4968 GE 4969
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 97.8 bits (242), Expect = 4e-20
Identities = 202/1009 (20%), Positives = 364/1009 (36%), Gaps = 157/1009 (15%)
Query: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEA---------------ETAKATPRLA 106
+R++ +++ + KK+R+S S S SS + + ++ PR +
Sbjct: 738 QRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797
Query: 107 STNSSVLGADL---------PSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSP 157
+ SS A SS K K++T +S PHP + SG P
Sbjct: 798 RSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHP-------KVKSGTPP 850
Query: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTS-----SSSDETDV 212
R+ + S S T + S F ++ P + S + S +S SS+
Sbjct: 851 RQGSITSPQANEQSVTPQRRS--CFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQS 908
Query: 213 EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAK-------- 264
+ S +VKA + S + ++P+P +V T + ++ P +
Sbjct: 909 PSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYS 968
Query: 265 -----------KPEEESESSEEGSES-----EEEAPAGTRSQVKASEKILQVRAASAPAK 308
KPE S GS S + + P G S + Q ++ + +
Sbjct: 969 HSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGP-SLSGSKSPCPQEKSKDSLVQ 1027
Query: 309 GTPG--------KGATPAPPGKAGAVASQTKAGK---PEEDSESSSEESSDSEEETPAAK 357
PG K +TP G + Q K P+ S++SS E S E+P+ +
Sbjct: 1028 SCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQ 1087
Query: 358 ALLQ-------AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS 410
+ Q +++S +++ + S ++ A+P P ++ Q+ +
Sbjct: 1088 SKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPT 1147
Query: 411 --------QSSSEESDSEEEA--PAQAKPSGKAPQVRAASAPAKESPR-------KGAAP 453
QS E ++S+E+ P Q + P+ + +P R K
Sbjct: 1148 VDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLR 1207
Query: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK-----SPQVKP 508
PPR+ A + + +Q +SS+ D E + + ++ +P G+ S ++K
Sbjct: 1208 TPPRERSGAGSSPETKEQNSALPTSSQ----DEELMEVVEKSE-EPAGQILSHLSSELKE 1262
Query: 509 ASTMGMGPLGK-GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
ST + P + + A + E S +SS S + +P
Sbjct: 1263 MSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPL 1322
Query: 568 QEKSLGNILQAKP---------TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA 618
+E S G+ L+ + T ++ GP Q++ + +D E S SS +
Sbjct: 1323 RENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHS 1382
Query: 619 DSEEAPAAMTAA--QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
SE +P A+ A + ++ P A P+ + S+ + + PR + S +
Sbjct: 1383 SSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTP-SRRSRS 1441
Query: 677 GSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLG 736
GSSP + G+ P+ S S ++ + + S G+ + S P +L
Sbjct: 1442 GSSPGLRDGSGTPSRHSLSGSSPGMKD--------IPRTPSRGRS---ECDSSPEPKALP 1490
Query: 737 QGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAA 796
Q P + P + Q + SE D + A +P ++ +Q +
Sbjct: 1491 QTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPS 1550
Query: 797 ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVAT 856
A + S+P +QRS S P V + + S P V
Sbjct: 1551 ASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRA 1610
Query: 857 AAQAQTGPEED----------------SGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
A +AQ+G + SGSS + E + + P + R A
Sbjct: 1611 APRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPE-HPPKSRTAR 1669
Query: 901 APAKESPR-KGAAPTPP----GKTGPS---AAQAGKQDDSGSSSEESDS 941
++ SP K + TPP ++ P A+ ++ S SSS E+ S
Sbjct: 1670 RGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRS 1718
Score = 80.9 bits (198), Expect = 5e-15
Identities = 190/981 (19%), Positives = 349/981 (35%), Gaps = 141/981 (14%)
Query: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEK 131
Q KK + D SESS E + + K R S + S + K K K++ +K
Sbjct: 187 QKKKKKKKDRGRRSESSSPRRERKKSSKKKKHR--SESESKKRKHRSPTPKSKRKSKDKK 244
Query: 132 AGKTGNSMPHP--------ATGKTVANLLSGKSPRKSAEPSANTTLV--------SETEE 175
++ ++ P P + + ++ + +S +SA +TT + S
Sbjct: 245 RKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRG 304
Query: 176 EGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSD-----ETDVEGKPSVKPAQVKASSVST 230
EG P ++PG S + S T S + D + K + +P+ S +
Sbjct: 305 EGDAP----FSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTG 360
Query: 231 KESPARKAAPAPGKVGD-----VTPQVKGGALPPAK----RAKKPEEESESSEEGSESEE 281
E PA A G TP + PP++ R + P + E + S SE
Sbjct: 361 PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSES 420
Query: 282 EAPAGTRSQVKASEKILQVRAASAPAKGTPGK-GATPAPPGKAGAVA------SQTKAGK 334
P+ ++V APA G+ + ++P ++ A S T + +
Sbjct: 421 SPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRR 480
Query: 335 PEEDSESSSEESSDSEEETPAAKALLQAKA-----SGKTSQVGAASAPAKESPRKGAAPA 389
++ + S TP + ++++ S + G + +P + + +P
Sbjct: 481 MGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRG--RSRSPQ 538
Query: 390 PPG----------------KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKA 433
PG + G + +++ A + S++ + S PA+ + +
Sbjct: 539 RPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRT 598
Query: 434 PQVRAASA--PAKESPRKGAAPA------------------PPRKTGPAAAQVQVGKQEE 473
P R + + PA+ + PA P R++G + ++ +
Sbjct: 599 PTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRS 658
Query: 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPAT 533
SR+ + S R A + + + + + + S + V G+ T
Sbjct: 659 RSRTPARRGRS-RSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRT 717
Query: 534 PSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP-AKGPPQKA 592
P + S S + S +S + +P +KS + +++ SSP +K + +
Sbjct: 718 PQR---RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLS 774
Query: 593 GPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP---QTKACPKKTN 649
++ + P S++ S S S+ + T + + P Q P + +
Sbjct: 775 LRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQS 834
Query: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLA 709
++S+ V+ GT P + G+ TSP + +V +R +SS E S
Sbjct: 835 HSSSSPHPKVKSGT--PPRQGSITSPQANEQSVT-PQRRSCFESSPDPELKSR------- 884
Query: 710 VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAP-------VLP------GKTGPTVTQVKA 756
T + G +S P + S + ++P + P G + P+ ++V +
Sbjct: 885 -TPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS 943
Query: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
S + E+ P + K P S G+IS KV
Sbjct: 944 RTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQT 1003
Query: 817 AQAKQRSPSKVKPPVRNPQNSTV--------LARGPASVPSVGK------AVATAAQAQT 862
S SK P ++S V L G S G+ ++ Q+QT
Sbjct: 1004 PPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQT 1063
Query: 863 GPEEDSG-SSEEESDSEEEAETL---AQVKP-SGKTHQIRAALAPAKESP----RKGAAP 913
P+ S SS E S E+ +L +Q P G++ A SP R +
Sbjct: 1064 SPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSA 1123
Query: 914 TPPGKTGPSAAQAGKQDDSGS 934
+P K+G S Q+ Q DS S
Sbjct: 1124 SPMLKSGMSPEQSRFQSDSSS 1144
Score = 76.3 bits (186), Expect = 1e-13
Identities = 152/761 (19%), Positives = 277/761 (36%), Gaps = 93/761 (12%)
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
A++ AP P K + + P K+ KK +++ + G SE +P R + K S
Sbjct: 160 AKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKK----DRGRRSESSSP---RRERKKS 212
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAV-------ASQTKAGKPEEDSESSSEESS 347
K + R+ S K K +P P K + S T A K S+S +S+
Sbjct: 213 SKKKKHRSESESKKR---KHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSA 269
Query: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
S + T +++ A + T+ G + +PA S R+G AP ++ G
Sbjct: 270 SSSD-TSRSRSRSAAAKTHTTALAGRSPSPA--SGRRGEGDAP---------FSEPGTTS 317
Query: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQ 467
SS E + + +P + K K + ++A+ P+ R P PP T P A+
Sbjct: 318 TQRPSSPETATKQPSSPYEDKDKDK--KEKSATRPSPSPERSSTGPEPPAPT-PLLAERH 374
Query: 468 VGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP-P 526
G + + + + + + A+ + P KSP+ P S+ + + P P P
Sbjct: 375 GGSPQPLATTPLSQEPVNPPSEASPTRDRSPP--KSPEKLPQSSS-----SESSPPSPQP 427
Query: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS-SPA 585
KV S+ + S E S S PT ++ +S G + K S +P+
Sbjct: 428 TKVSRHASSSPESPKPAPAPGSHREISSS-----PT----SKNRSHGRAKRDKSHSHTPS 478
Query: 586 KGPPQKAGPVAV---QVKAEKPMDNSESSEESSDSADSEEAP--AAMTAAQAKPALKIPQ 640
+ + P + ++ P S S S A + Q + + PQ
Sbjct: 479 RRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQ 538
Query: 641 TKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAG--GTQRPAEDSSSSEE 698
+ NT + R G R T +PA G ++ PA S S
Sbjct: 539 RPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRT 598
Query: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV---------LPGKTGP 749
++ G+++S + PV+ + +P P + G
Sbjct: 599 PTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVR-RRSRSRSPARRSGRSRSRTPARRGR 657
Query: 750 TVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAA----------ARA 799
+ ++ A + + + +PA+ S +T + + +R
Sbjct: 658 SRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRT 717
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
P +G + + + +++RS S P ++ + S+ +R +S S K+ + +
Sbjct: 718 PQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRR 777
Query: 860 AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919
+ +G S +++S + +P K+ P + S R ++P P K
Sbjct: 778 SLSG---SSPCPKQKSQTPPRRSRSGSSQPKAKSR------TPPRRS-RSSSSPPPKQK- 826
Query: 920 GPSAAQAGKQDDSGSSSEESDSDGEAP--AAVTSAQDQESS 958
+ +Q S SS G P ++TS Q E S
Sbjct: 827 ---SKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQS 864
Score = 71.6 bits (174), Expect = 3e-12
Identities = 121/513 (23%), Positives = 191/513 (37%), Gaps = 66/513 (12%)
Query: 43 PVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRV-SDPISTSESSEEEEEAEAETAKA 101
PV L+ + T + L + A AA+ R + P + + + A A A
Sbjct: 2214 PVPLMSLRT--APAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLA 2271
Query: 102 TPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRK 159
+PR A S+V AD P++ A S+ T T AN S +
Sbjct: 2272 SPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSS---R 2328
Query: 160 SAEPSANTTLVSETEEEGSVPA-------FGAAAKPGMVSAGQADSSSEDTSSS-----S 207
+ + A+ LV + P A A + SA A + S +S S
Sbjct: 2329 TPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLS 2388
Query: 208 DETDVEGKPSVKPAQVKASSVSTKESPAR-----KAAPAPG-KVGDVTPQVKGGALPPAK 261
V G+ S P +A S + +P++ + AP+P ++G Q LPPA+
Sbjct: 2389 AYERVSGRTS-PPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQ---SLLPPAQ 2444
Query: 262 ---RAKKPEEESESSE---------EGSES-EEEAPAGTRSQVKASEKILQVRAASAPAK 308
R+ P S+ S GS+S A A T S +L V A P
Sbjct: 2445 DQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHS 2504
Query: 309 --GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
G P P A+ + S SSS SS S + ++ + + S
Sbjct: 2505 DVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSE 2564
Query: 367 KTS----------QVGAASAPAKESPRKGAAPAP-PGKTGPAVAKAQAGKREEDSQSSSE 415
+S +V + + KE+ R+G P P P K + + + S SSS
Sbjct: 2565 GSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSS 2624
Query: 416 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDS 475
S S + + + S + ++ +PAK P+ PA P+K P E S
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPG---------ERRS 2675
Query: 476 RSSSEESDSDREALAAMNAAQVKPLGKSPQVKP 508
RS + DS R++ +++ + V+ SPQ P
Sbjct: 2676 RSPRKPIDSLRDS-RSLSYSPVERRRPSPQPSP 2707
Score = 70.1 bits (170), Expect = 9e-12
Identities = 104/464 (22%), Positives = 164/464 (35%), Gaps = 44/464 (9%)
Query: 26 AAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTS 85
AA + S + V L D T L R AAL + +
Sbjct: 2264 AAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANY 2323
Query: 86 ESSEEEEEAEAETAKATPRLASTNSSV-------LGADLPSSMKEKAKAET-EKAGKTGN 137
SS +A A PR A + V A P+S+ A A T
Sbjct: 2324 PSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSP 2383
Query: 138 SMPHPA----TGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSA 193
+P A +G+T LL R + + + SE S G A ++
Sbjct: 2384 RVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPS-SRMGQAPSQSLLPP 2442
Query: 194 GQADSSSEDTSSSSDE--------TDVEGKPSVKPAQVKASSVSTKESPARKAAPAPG-- 243
Q S S+ SD+ T V G S+ V ++ S + + PAPG
Sbjct: 2443 AQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVP 2502
Query: 244 --KVGDVTPQVKGGALPPAKRAKKPEEE---SESSEEGSESEEEAPAGTRSQVKASEKIL 298
VG+ P G P A A +P +E S SS S S + + + S +
Sbjct: 2503 HSDVGE-PPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS 2561
Query: 299 QVRAASAPAKGTPGKGATPAP-PGKAGAV----------ASQTKAGKPEEDSESSSEESS 347
+S P + P+P P AV A + + S SSS SS
Sbjct: 2562 DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSS 2621
Query: 348 DSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
S + ++ + + +S +S ++ +PAK P+ PA P K P ++++ ++
Sbjct: 2622 SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKP 2681
Query: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVR-AASAPAKESPRKG 450
D S +S S +P + + P R S+ ++ R+G
Sbjct: 2682 ID---SLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRG 2722
Score = 69.7 bits (169), Expect = 1e-11
Identities = 170/918 (18%), Positives = 301/918 (32%), Gaps = 63/918 (6%)
Query: 60 GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLA------STNSSVL 113
G +R + + TR D +S+S+ + ++ T R S + +
Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQ 1828
Query: 114 GADLPSSMKEKAKAETEKAG-KTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSE 172
+ SS + + ++ T K S PA K + S + R+S + T L+S
Sbjct: 1829 ESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSR---SRTPLISR 1885
Query: 173 TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232
S + S S S S P V + ++ + +T+
Sbjct: 1886 RRSRSRTSPVSRRRSRSRTSVTRRRSRSR-ASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944
Query: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVK 292
+ P VT + PP R + S + S S RS+ +
Sbjct: 1945 RSRSRTPP-------VTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSR 1997
Query: 293 ASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES--SDSE 350
S + + R+ S + T + + PP S+T P + S S S + S
Sbjct: 1998 TSP-VTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPL-LPRKRSRSRSPLAIRRRSR 2055
Query: 351 EETP-AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKR 406
TP A+ S + +AS + + R PA +G P VA +
Sbjct: 2056 SRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMS 2115
Query: 407 EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQV 466
S S +P +P G + + A S G P P
Sbjct: 2116 CFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIP---------- 2165
Query: 467 QVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526
+ R+S E+ + A+ A + P + A + + PVP
Sbjct: 2166 ------DHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAAR--MSQVPAPVPL 2217
Query: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS---LGNILQAKPTSS 583
+ A P+A + + +++ + + +PTAV A ++ + A P ++
Sbjct: 2218 MSLRTA-PAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTA 2276
Query: 584 PAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 643
A A P A + ++ S P TAA + + PQ A
Sbjct: 2277 VAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPP--TAANYPSSSRTPQAPA 2334
Query: 644 CPKKTNTTASAKVAPVRVGTQ--APRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
++ APV + A A + + A +PA++G S+ E S
Sbjct: 2335 SANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVS 2394
Query: 702 EEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
L + + S P + + AP + G +Q +D
Sbjct: 2395 GRTSPPL---------LDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQD 2445
Query: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
S S + + T V +Q+ ++ A A S+ G + V
Sbjct: 2446 QPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSD 2505
Query: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
+ P L S + ++++ + + S SS S S+ E
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565
Query: 882 ETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGKQDDSGSSSEESD 940
+L V+P ++ + KE+ R+G P P P K ++ + S SSS S
Sbjct: 2566 SSLP-VQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSS 2624
Query: 941 SDGEAPAAVTSAQDQESS 958
S + ++ +S+ SS
Sbjct: 2625 SSSSSSSSSSSSSSSSSS 2642
Score = 67.0 bits (162), Expect = 8e-11
Identities = 157/801 (19%), Positives = 280/801 (34%), Gaps = 144/801 (17%)
Query: 243 GKVGDVTPQVKG--GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQV------KAS 294
G+ TPQ +G G+ K + + S E ++ + RS+ KA
Sbjct: 711 GRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAK 770
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
++ R+ S + K TP ++G+ + K+ P S SSS + +TP
Sbjct: 771 SRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTP 830
Query: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSS 414
S+ +S+ + G P T P + + SS
Sbjct: 831 --------------SRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESS 876
Query: 415 EESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAP-------PRK------TGP 461
+ + + P++ SG +P +S P ++SP + ++P P PR+ + P
Sbjct: 877 PDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSP 936
Query: 462 AAAQVQVGKQEEDSRSSSEESDSDREAL-------AAMNAAQVKP-----------LGKS 503
+ ++V SRS S S+ + L ++ +VKP +
Sbjct: 937 SPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPY 996
Query: 504 PQVKPASTMG-----------------------MGPLGKGAG---PVPPGKVGPATPSAQ 537
P+VK + G G L AG PPG+ S Q
Sbjct: 997 PKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQ 1056
Query: 538 VGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAV 597
+ + S++S + SD+S EV Q S LQ+K +SP G + + PV
Sbjct: 1057 L---KGQSQTSPDHRSDTSSPEV------RQSHSESPSLQSKSQTSPKGGRSRSSSPVTE 1107
Query: 598 ------------QVKAEKPMDNSESSEESSDSADSEEAP----------AAMTAAQAKPA 635
+ A + + S E+S +DS P + + A++K
Sbjct: 1108 LASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK 1167
Query: 636 LKIP---QTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED 692
+ +P A P + S R + K T P S AG + E
Sbjct: 1168 MALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSG--AGSSPETKEQ 1225
Query: 693 SSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVT 752
+S+ S +EE + V + G+ L ++ + + ++P + + ++T
Sbjct: 1226 NSALPTSSQDEEL--MEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLT 1283
Query: 753 QVKAEKQEDSESSEEESDSEEAAA---SP--AQVKTSVKKTQAKANPAAARAPSAKGTIS 807
+++ Q E+ E S + SP ++ S + + +P R GT
Sbjct: 1284 LDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEM 1343
Query: 808 APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE-- 865
G S+VK + P + + + + + ++ P+
Sbjct: 1344 NTG------------FSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAV 1391
Query: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
E +G S +S S + + + PS R + A K P P + S +
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRT-PS------RERSSSASSPEMKDGLPRTPSRRSRSGSS 1444
Query: 926 AGKQDDSGSSSEESDSDGEAP 946
G +D SG+ S S S G +P
Sbjct: 1445 PGLRDGSGTPSRHSLS-GSSP 1464
Score = 64.7 bits (156), Expect = 4e-10
Identities = 156/764 (20%), Positives = 250/764 (32%), Gaps = 119/764 (15%)
Query: 188 PGMVSAGQADSSSEDTSSSSDETDVEGKPSVK--PAQVKASSVSTKESPARKAAPAPGKV 245
P + A SS D S S+ + P + +S +S P+ P
Sbjct: 2072 PPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTP----- 2126
Query: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA-GTRSQVKASEKILQVRAAS 304
+ G L P ++ P + + GS + P + E Q R A
Sbjct: 2127 --LDRCRSPGMLEPLGSSRTPMSVLQQAG-GSMMDGPGPRIPDHQRTSVPENHAQSRIAL 2183
Query: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKA 364
A + G P AG A ++ P + +++ PAA A A
Sbjct: 2184 ALTAISLGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLA 2243
Query: 365 SGKTSQV------------GAASAPAKESPRKGAAPA------PPGKTGPAVAKAQAGKR 406
S +T + AA+A SPR AP+ P T PAV A A
Sbjct: 2244 SARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGA--- 2300
Query: 407 EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQV 466
A A +G AA+ P+ S R APA GP +A
Sbjct: 2301 ------------RTPAALAALSLTGSGTPPTAANYPS--SSRTPQAPASANLVGPRSAHA 2346
Query: 467 QVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526
SR+++ ALA + + M P GA
Sbjct: 2347 TAPVNIAGSRTAA--------ALAPASLTSAR---------------MAPALSGANLT-- 2381
Query: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586
+P + +E S +S D + P + AP+Q + TS A
Sbjct: 2382 ------SPRVPLSAYERVSGRTSPPLLDRARSRTPPS-APSQSRM---------TSERAP 2425
Query: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPK 646
P + G Q D S S+ S S A T +L
Sbjct: 2426 SPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAV----- 2480
Query: 647 KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ-------RPAED--SSSSE 697
TT+SA + AP G S G PA G Q +PA++ SSSS
Sbjct: 2481 -ATTTSSAGDHNGMLSVPAP---GVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSS 2536
Query: 698 ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL------GQGTAPVLPGKTGPTV 751
S S + + + + S + +S+PV+ + AP + G
Sbjct: 2537 SSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPP 2596
Query: 752 TQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGK 811
A+++ S SS S S +++S + +S + + ++ +++ + S+ + + PG
Sbjct: 2597 EPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPG- 2655
Query: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSS 871
A K SP K P R ++ R P ++++ + + P
Sbjct: 2656 ---PQALPKPASPKKPPPGERRSRS----PRKPIDSLRDSRSLSYSPVERRRPSPQPSPR 2708
Query: 872 EEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
+++S S E Q S R P+ R ++ +P
Sbjct: 2709 DQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752
Score = 64.3 bits (155), Expect = 5e-10
Identities = 95/450 (21%), Positives = 166/450 (36%), Gaps = 56/450 (12%)
Query: 66 EEDAALQAKK--TRVSDPISTSESSEEEEEA--------EAETAKATPRLASTNSSVLGA 115
E D +L K+ TR S S+ S + E+A + A PR S S +
Sbjct: 1364 ETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSAS 1423
Query: 116 DLPSSMKEKAKAETEKAGKTGNSMP-HPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
MK+ + ++G+S +G + LSG SP P + SE +
Sbjct: 1424 S--PEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECD 1481
Query: 175 EEGSVPAFGAAAKPGMVSAGQADSSSE----DTSSSSDETDVEGKPSVK-PAQVKASSVS 229
A +P S + +++ S E+ V+ K + P ++ S S
Sbjct: 1482 SSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGS 1541
Query: 230 TKESPAR-KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
++E + A+P D +P K P ++ + E + S + +G+
Sbjct: 1542 SQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS 1601
Query: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD 348
+VK + A + G ++P P A + S E S
Sbjct: 1602 PEVKDKPR--------AAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSS 1653
Query: 349 SEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE 408
S E +P + +T++ G+ S+P ++ + ++ P + + R
Sbjct: 1654 STESSP------EHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRS 1707
Query: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQV----------RAASAP-AKESPRKGAAPAP-P 456
S SSS E+ S + PS +P+ R+AS+P K + R+G +P+P P
Sbjct: 1708 RSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKP 1767
Query: 457 RKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
R G Q SRS E++ + R
Sbjct: 1768 R-----------GLQRSRSRSRREKTRTTR 1786
Score = 57.4 bits (137), Expect = 6e-08
Identities = 180/920 (19%), Positives = 343/920 (37%), Gaps = 105/920 (11%)
Query: 72 QAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG-ADLPSSMKEKAKAETE 130
+ +++ P S+S + + ++ LAS + + +S K+ E
Sbjct: 1075 EVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPE 1134
Query: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
++ +S +P +N L G+S ++AE L + + S P
Sbjct: 1135 QSRFQSDSSSYPTVD---SNSLLGQSRLETAESKEKMALPPQEDATASPPR--------- 1182
Query: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVK-PAQVKASSVSTKESPARKAAPAPGKVGDVT 249
Q D S E+ + K +++ P + ++ + S+ E+ + +A +
Sbjct: 1183 ----QKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEEL 1238
Query: 250 PQVKGGALPPAKR-----AKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAAS 304
+V + PA + + + +E S S+ E S EE PA + + + S+ + A
Sbjct: 1239 MEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLT-LDQSQSQASLEAVE 1297
Query: 305 APAKGTPGKGATPAPPGK--AGAVASQTKAGKPEE-------DSESSSEESSDSEEET-- 353
P+ + G +P K + + + G P E +E ++ SS+ +E+
Sbjct: 1298 VPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNG 1357
Query: 354 PAAKAL-----LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV-AKAQAGKRE 407
P L L K S ++S + ++ K + + P + A + RE
Sbjct: 1358 PFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRE 1417
Query: 408 EDSQSSSEE-SDSEEEAPAQAKPSGKAPQVRAASA-PAKES--------------PRKG- 450
S +SS E D P++ SG +P +R S P++ S P +G
Sbjct: 1418 RSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGR 1477
Query: 451 ----AAPAP--------PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK 498
++P P PR P++ ++ S ES D++ +A Q
Sbjct: 1478 SECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRS 1537
Query: 499 PLGKSPQ--VKPASTMGMGPLGKG-AGPVPPGKVGPATPSAQVGKW----EEDSES--SS 549
G S + VKP+++ P + + P K TP Q + E DS+S S
Sbjct: 1538 RSGSSQELDVKPSAS----PQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSP 1593
Query: 550 EESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE 609
S S EV A G+ +P + + P+++ + K P
Sbjct: 1594 RRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSS-KGRGPSPEGS 1652
Query: 610 SSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA--CPKKTNTTASAKVAPVRVGTQAPR 667
SS ESS E P + TA + + P+TK+ P++ ++ +S ++ ++ R
Sbjct: 1653 SSTESSP----EHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708
Query: 668 KAGTATSPAGSSP-----AVAGGTQRPAEDSSSSEESDS-EEEKTGLAVTVGQAKS-VGK 720
A ++ +P + + + PAE S SS S +T G++ S +
Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPR 1768
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
GLQ ++ S + G + T + + + + S + SPA+
Sbjct: 1769 GLQ-RSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPAR 1827
Query: 781 ---VKTSVKKTQAKA-NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQN 836
+TS ++ + ++ P +R S T AP K + A S+ + P+ + +
Sbjct: 1828 QESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRR 1887
Query: 837 STVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQI 896
S + S + T ++++ S S S S T + + T +
Sbjct: 1888 SRSRTSPVSRRRSRSRTSVTRRRSRS---RASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944
Query: 897 RAALAPAKESPRKGAAPTPP 916
R+ + R+ + TPP
Sbjct: 1945 RSRSRTPPVTRRRSRSRTPP 1964
Score = 47.8 bits (112), Expect = 5e-05
Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 19/226 (8%)
Query: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAE 128
AALQ K R S S+S SS + + ++ ++ +S++S G+ LP +
Sbjct: 2522 AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSE--GSSLP--------VQ 2571
Query: 129 TEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS-ANTTLVSETEEEGSVPAFGAAAK 187
E A K S P PA + V G+ P EP+ A S + S + +++
Sbjct: 2572 PEVALKRVPS-PTPAPKEAVRE---GRPP----EPTPAKRKRRSSSSSSSSSSSSSSSSS 2623
Query: 188 PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGD 247
S+ + SSS +SSSS + P + + K P + + +P K D
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPID 2683
Query: 248 VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293
+ + P +R + + S ++ S SE + G R ++
Sbjct: 2684 SLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRS 2729
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 97.1 bits (240), Expect = 7e-20
Identities = 148/735 (20%), Positives = 260/735 (35%), Gaps = 121/735 (16%)
Query: 244 KVGDVTPQVKGGALP-PAKRA---KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
KV ++P+ GA P K A ++ + E+ E AP T + ++ +
Sbjct: 1666 KVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQG 1725
Query: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTK---AGKPEEDSESSSEESSDSEEETPAA 356
P + G G G+ ++ K G+ E D+ + E ET A
Sbjct: 1726 AEGGLGPGL-SQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAG 1784
Query: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
L G+ Q G + E+ +G+ G +A AG ++ QS E
Sbjct: 1785 SEL------GEAEQEGEGISERGETGGQGS-----GHEDNLQGEAAAGGDQDPGQSDGAE 1833
Query: 417 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA-------APAPPRKTGPAAAQVQVG 469
EA +A+P + + A A+E+ + AP + P + V+
Sbjct: 1834 GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETP 1893
Query: 470 KQEEDSRSSSEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
+ E + + SE +++ + E A V+ L + +P S + A G+
Sbjct: 1894 EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQ 1953
Query: 529 VGPATPSAQVGKWEEDSESSSEE-----------------SSDSSDGEVPTAVAPAQEKS 571
P + + + EE+++ SE+ +S D E P A QE
Sbjct: 1954 TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013
Query: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
+A+P S + P+ G A +V+ E ++ ES D EAP A AQ
Sbjct: 2014 E----EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES----DGVEAPEAEEEAQ 2065
Query: 632 -AKPALKIPQTKACPKKTNTTAS---AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
A+ ++ + +A P+ + A + P G +AP G A G G
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
Query: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKT 747
+P + + E++ E + P
Sbjct: 2126 QPESEGIEAPEAEGEAQ---------------------------------------PESE 2146
Query: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
G + E Q +SE E + EEA V+ + +A+ AP A+G
Sbjct: 2147 GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206
Query: 808 APGKVVTA--AAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
+ V A A + Q P V+ P A G A S G+ T + + P+
Sbjct: 2207 PELEGVEAPEAEEEAQPEPEGVETPE---------AEGEAQPESEGE---TQGEKKGSPQ 2254
Query: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
G + E ++ E + + + +P+ +P ++P + P +TGPS+++
Sbjct: 2255 VSLGDGQSE-EASESSSPVPEDRPTPPP-------SPGGDTPHQ----RPGSQTGPSSSR 2302
Query: 926 AGKQDDSGSSSEESD 940
A + E+D
Sbjct: 2303 ASSWGNCWQKDSEND 2317
Score = 84.7 bits (208), Expect = 4e-16
Identities = 133/677 (19%), Positives = 254/677 (37%), Gaps = 48/677 (7%)
Query: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE-KA 125
ED + R DP + E E +A A+ + + T++ G++L + +E +
Sbjct: 1744 EDGEGSQRLNRDKDP----KLGEAEGDAMAQEREGKTHNSETSA---GSELGEAEQEGEG 1796
Query: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
+E + G G+ G+ A + P +S A E E E + G
Sbjct: 1797 ISERGETGGQGSGHEDNLQGEAAAG--GDQDPGQS--DGAEGIEAPEAEGEAQPESEGVE 1852
Query: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
A A +A+ ++ S + + EG+ + V+ + P + A AP
Sbjct: 1853 APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912
Query: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRA 302
+ P+ + + +PE E ++E E+ +EA T+ + +++ E + +
Sbjct: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQP 1972
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES---SDSEEETPAAKAL 359
S + + T G+A + +A + E + + + EE+ SD E P ++
Sbjct: 1973 ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
Query: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
+ G+T + + P + AP + A+ + + E ++ SE+ D+
Sbjct: 2033 EAQEVEGETQKTEGDAQPESD-----GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA 2087
Query: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRKG-AAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
+EA +A+P + V A A + +G AP + P + ++ + E +++
Sbjct: 2088 -QEAEGEAQPESEG--VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144
Query: 479 SEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG-AGPVPPGKVGP-ATPS 535
SE ++ D E A + ++ + +P P +G A P G P A
Sbjct: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
Query: 536 AQVGKWEEDSESSSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA-- 592
AQ ++ + EE+ +G E P A AQ +S G T KG PQ +
Sbjct: 2205 AQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGE------TQGEKKGSPQVSLG 2258
Query: 593 -GPVAVQVKAEKPMDNSESSEESSDSADS-EEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
G ++ P+ + S D+ + P + T + A + +
Sbjct: 2259 DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318
Query: 651 TASAKVAPVRVGTQAPRKAGTAT-----SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
+P T P AT S G++ P + +S + ++
Sbjct: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQAL 2378
Query: 706 TGLAVT--VGQAKSVGK 720
LA T VG+A G+
Sbjct: 2379 GSLAPTEAVGRADGFGQ 2395
Score = 80.5 bits (197), Expect = 7e-15
Identities = 95/451 (21%), Positives = 175/451 (38%), Gaps = 33/451 (7%)
Query: 57 SELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA- 115
SE ++AEE A +T+ + S+ +EEE + E+E +A T + A
Sbjct: 1935 SEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQ 1994
Query: 116 ------DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRK--SAEPSANT 167
+ P + E +AE E ++ P + A + G++ + A+P ++
Sbjct: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054
Query: 168 TLVSETEE-----EGSVPAFGAAAKPGM--VSAGQADSSSEDTSSSSDETDVEGKPSVKP 220
E EE EG V A P V A +A+ ++ S + + EG+ + K
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE-AQKA 2113
Query: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE---ESESSEEGS 277
++A + P + AP G+ P+ +G A+ +PE E++ +EE +
Sbjct: 2114 EGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
Query: 278 ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE 337
+ E E ++ +A + + A A + P AP + A PE
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEA 2233
Query: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG----- 392
+ E+ E +++ E + + + G++ + +S+P E R P+P G
Sbjct: 2234 EGEAQPESEGETQGEKKGSPQV--SLGDGQSEEASESSSPVPED-RPTPPPSPGGDTPHQ 2290
Query: 393 ----KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448
+TGP+ ++A + S ++ + +P AK +G R A+ ES
Sbjct: 2291 RPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSP-DAKSTGTPHAERKATRMYPESST 2349
Query: 449 KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS 479
AP P + +ED S
Sbjct: 2350 SEQEEAPLGSRTPEQGASEGYDLQEDQALGS 2380
Score = 72.8 bits (177), Expect = 1e-12
Identities = 170/841 (20%), Positives = 302/841 (35%), Gaps = 124/841 (14%)
Query: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-----VKPAQVKASSVSTKESPAR- 236
G A + G+ G + S S+ + +GK S V+ + +S S + PA
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
Query: 237 --KAAPAPGKVGDVTPQVK----GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
+ P + + P G L P +KP + +E ++++ A RS
Sbjct: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPG--LEKPPGATMMGQEHTQAQPTQGAAERSS 1504
Query: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
A L + A A A AVA + +A +D++ + +++ +
Sbjct: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH--LASAVA-ELRARWGLQDNDLLDQMAAELQ 1561
Query: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--- 407
++ A+ L + G A E PR+ TG + + Q +
Sbjct: 1562 QDV--AQRLQDSTKRELQKLQGRAGRMVLEPPREAL-------TGELLLQTQQRRHRLRG 1612
Query: 408 --------EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPP 456
E + S + E+ PA + G A P + RK +P P
Sbjct: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSP 1672
Query: 457 RKT-----GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511
+ T GP + Q+ R E +D + AA+V P GK+ P ST
Sbjct: 1673 KATMGATRGPIKEAFDL--QQILQRKRGEHTDGE--------AAEVAP-GKT-HTDPTST 1720
Query: 512 M-------GMGPLGKGAGP-VPPGKVGPATP------SAQVGKWEEDSESSSEES-SDSS 556
G+GP G GP V G+ G + ++G+ E D+ + E + +S
Sbjct: 1721 RTVQGAEGGLGP-GLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNS 1779
Query: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
+ + + A+++ G I + T G A + P SD
Sbjct: 1780 ETSAGSELGEAEQEGEG-ISERGETGGQGSGHEDNLQGEAAAGGDQDP--------GQSD 1830
Query: 617 SADSEEAPAAMTAAQAKP-ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-- 673
A+ EAP A AQ + ++ P+ + ++ A + P +AP G A
Sbjct: 1831 GAEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPE 1886
Query: 674 SPAGSSPAVAGGTQRPAEDSSSSE---ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
S +P Q +E + + E E+ E E T G+ + +G + + A
Sbjct: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
Query: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE-ESDSEEAAASPAQVKTSVKKTQ 789
+ + GQ TQ ++E E E+ EE + +SE+ A +V+T + +
Sbjct: 1947 AQEAEGQ--------------TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
Query: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
A+ AP A+G + + + + P + + T G A S
Sbjct: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
Query: 850 VGKAVATA-------------AQAQTGPE-EDSGSSEEESDSEEEAETLAQVKPSGKTHQ 895
G A A+ + PE ED + E E +++ E+E + + G+ +
Sbjct: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQK 2112
Query: 896 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQ 955
AP E A P G P A + + G +++++ + + + AQ+
Sbjct: 2113 AEGIEAPETEGE---AQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEA 2169
Query: 956 E 956
E
Sbjct: 2170 E 2170
Score = 65.9 bits (159), Expect = 2e-10
Identities = 175/875 (20%), Positives = 298/875 (34%), Gaps = 152/875 (17%)
Query: 204 SSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263
+++ DE + + + + ++ + +T + + G G+ Q + L K
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGL-QEEAVQLEETKTE 1328
Query: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
+ +EE EE E+E E +Q+ E+I + +G + P G
Sbjct: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQL---EEIEETGGEGLQEEGVQLEEVKEGPEGGL 1385
Query: 324 GAVASQT---KAGKPEEDS-------ESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
A + + G PEE S E+SS + S+E+ P +Q + +G+ S A
Sbjct: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDP-----VQEEEAGRAS-ASA 1439
Query: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE--------------------DSQSS 413
PA+ + P+ +T P+ ++ Q+G + E +Q +
Sbjct: 1440 EPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGA 1499
Query: 414 SEESDSEEEAPA----------QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
+E S S + A K + KA ASA A+ R G A
Sbjct: 1500 AERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAE 1559
Query: 464 AQVQVGKQEEDS----------RSSSEESDSDREALAAMNAAQVKPLG------KSPQVK 507
Q V ++ +DS R+ + REAL Q + ++
Sbjct: 1560 LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF 1619
Query: 508 PASTMGMGP--------------LGKGAGPVPPG------------KVGPATPSAQVGKW 541
T+G+GP LG G G KV P +P A +G
Sbjct: 1620 SERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGAT 1679
Query: 542 EEDSESS-------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS-PAKGPPQKAG 593
+ + + + +DGE VAP + PTS+ +G G
Sbjct: 1680 RGPIKEAFDLQQILQRKRGEHTDGEA-AEVAPGK-------THTDPTSTRTVQGAEGGLG 1731
Query: 594 PVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
P Q ++ E S+ + D + EA A + + +T A +
Sbjct: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
Query: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
+ R G + +G + G A AGG Q P + + E E
Sbjct: 1792 QEGEGISER-GETGGQGSGHEDNLQGE--AAAGGDQDPGQSDGAEGIEAPEAE------- 1841
Query: 712 VGQAKSVGKGLQVKAASVPVKGSLGQG-------TAPVLPGKTGPTVTQV---KAEKQED 761
G+A+ +G++ A + + G+ AP G+ P V +AE +
Sbjct: 1842 -GEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ 1900
Query: 762 SESSEEESDSEEAAASPAQVKTSVKKTQ---------AKANPAAARAPSAKGTISAPGKV 812
ES E+ E A P +T+ A+A A A A+G +V
Sbjct: 1901 PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEV 1960
Query: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA------AQAQTGPEE 866
+ + ++ P + T A G A S A A+ + PE
Sbjct: 1961 IESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPES 2020
Query: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQ-----IRAALAPAKESPRKGAAPTPPGKTGP 921
D ++ +S+ EE E + + + Q + A A + +G G+ P
Sbjct: 2021 DGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
Query: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQE 956
+ Q+ G + ES+ EAP A AQ E
Sbjct: 2081 ESEDVDAQEAEGEAQPESEG-VEAPEAEGEAQKAE 2114
Score = 60.1 bits (144), Expect = 1e-08
Identities = 143/661 (21%), Positives = 245/661 (37%), Gaps = 99/661 (14%)
Query: 56 TSELGRKRKAE----EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
++++G +RKA ED L + P + E ++ ++ S S
Sbjct: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGS 545
Query: 112 VLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171
P KA+AET + + P SP S + L +
Sbjct: 546 SEWGGRPQGCPGKARAETSQQEASEGGDP--------------ASPALSLSSLRSDDLQA 591
Query: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
ET+ +G+ A GAA + G + S + +SS+ T + + + +AS++S+
Sbjct: 592 ETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSP 651
Query: 232 ESP-----ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
SP A + P T ++ K+ +P E + ++GS +
Sbjct: 652 SSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV--TKQVPRPPERRRACQDGSVPRYSG-SS 708
Query: 287 TRSQVKASEKILQVRAASAPAK---GTPGKGATPA---------------PPGKAGAVAS 328
+ ++ +AS + + S P++ GT TPA G AG S
Sbjct: 709 SSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGS 768
Query: 329 QTKAGKP----EEDSESSSEESSDSEE--ETPAAKALLQAKASGKTSQVGAASAPAKESP 382
+T + P DS S S +S EE +TP + L QVG A P
Sbjct: 769 RTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPL-------VLQVGRPEQGA-VGP 820
Query: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
+ + PG T PA +AQ G E S + P + +P PQ R++S
Sbjct: 821 HRSHCCSQPG-TQPA-QEAQRGPSPEASWLCGRYCPT----PPRGRP---CPQRRSSSCG 871
Query: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
+ S + A GP + + +Q + S S + R + A+ A + L +
Sbjct: 872 STGSSHQSTA------RGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGS-RGLSE 924
Query: 503 SPQVKPASTMGMGPLG-KGAGPVPPGKVGPATPSAQVGKWEED---------SESSSEES 552
++ G GP G + A V P + ++P A V +W ++ E + E +
Sbjct: 925 EKTLR----SGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETT 980
Query: 553 SDSSDGEVPTAVAPAQEKS---LGNILQAKPTS---SPAKGPPQKAGPVAVQVKAEKPMD 606
+ G V P + S LG QA S P + P + A+ ++
Sbjct: 981 GAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEG---ALLGSSDTGPQ 1037
Query: 607 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666
+ E + + EAPA A + PA +A P + +AS ++ +G++
Sbjct: 1038 SGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGR--VSASTQIMRALMGSKQG 1095
Query: 667 R 667
R
Sbjct: 1096 R 1096
Score = 35.0 bits (79), Expect = 0.34
Identities = 98/475 (20%), Positives = 164/475 (34%), Gaps = 64/475 (13%)
Query: 508 PASTMGMGPLGKGAGP-------VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG-- 558
PAS+ G L +G+ P P V A+PSAQ+G + S E+ DG
Sbjct: 455 PASSTG---LPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAG 511
Query: 559 ----EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG-PVAVQVKAEKPMDNSESSEE 613
E + P G + ++ +G + G P KA +E+S++
Sbjct: 512 LGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKA-----RAETSQQ 566
Query: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
+ +PA ++ L+ +T+ + T A+ P+ +G +
Sbjct: 567 EASEGGDPASPALSLSSLRSDDLQ-AETQGQGTEQATGAAVTREPLVLGL----SCSWDS 621
Query: 674 SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
A S+P+ +Q+ S + S GL + + K P+
Sbjct: 622 EGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYR-KDTHSPLDS 680
Query: 734 SLGQ--------------GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD---SEEAAA 776
S+ + G+ P G + T TQ + S S D + A
Sbjct: 681 SVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATV 740
Query: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV--TAAAQAKQRSPSKVKPPVRNP 834
+PA V P+A A A +P + T+ + +K + S + P
Sbjct: 741 TPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTP 800
Query: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH 894
Q S+ L V VG+ Q GP S+ + +E AQ PS +
Sbjct: 801 QPSSPL------VLQVGR----PEQGAVGPHRSHCCSQPGTQPAQE----AQRGPSPEAS 846
Query: 895 QI--RAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA 947
+ R P + P + G TG S+ Q+ + GS E + G P+
Sbjct: 847 WLCGRYCPTPPRGRPCPQRRSSSCGSTG-SSHQSTARGPGGSPQEGTRQPGPTPS 900
>gi|112821681 G protein-regulated inducer of neurite outgrowth 1
[Homo sapiens]
Length = 1008
Score = 94.4 bits (233), Expect = 5e-19
Identities = 184/824 (22%), Positives = 296/824 (35%), Gaps = 139/824 (16%)
Query: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293
P P G +G + ++ K + P + G ES +P+G
Sbjct: 24 PTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASC 83
Query: 294 SEKILQVRAASAPA----KGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349
S+ A +P + +P K A T +GKPE S +E S S
Sbjct: 84 SDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKS-S 142
Query: 350 EEETPAAKALLQAKASGKTSQVGAASAPAKESP---RKG---------------AAPAPP 391
++ P + K K+S+ +++ KE P RK P P
Sbjct: 143 DDRNP----MFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAP 198
Query: 392 GKTGPAVAKAQ----AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASA-PAKES 446
G+ P + + GK + S + +E P + + P KE
Sbjct: 199 GRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEE 258
Query: 447 PRKGAA--PAPPRKTGPAAAQ----VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
PR P K P +A+ V GK+ D S + E++ + + + +P
Sbjct: 259 PRYSGKEHPVSSEKVAPTSAEKVDLVLSGKR--DPGPSGKADPMPLESMDSASTGKTEP- 315
Query: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPS-------AQVGKWE------EDSE- 546
G ++ P S+ GP+ G G PG +G P+ A VG E EDS
Sbjct: 316 GLLGKLIPGSSGKNGPVSSGTGA--PGSLGRLDPTCLGMADPASVGNVETVPATKEDSRF 373
Query: 547 ------SSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 600
+SS E S TA A SL N+ P SS K P G +
Sbjct: 374 LGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNV---DPMSS-GKVDPVSLGKMDPMCS 429
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAM--TAAQAKPALKIPQTKACPKKTNTTASAKVAP 658
+ + + +E S +P +++ + + K +K N +S K P
Sbjct: 430 GKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNP 489
Query: 659 VRVGTQAPRKAGTATSP-------------------------AGSSPAVAGGTQRP---- 689
V G PR GTA P +G + A G P
Sbjct: 490 VSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVG 549
Query: 690 AEDSSSSEESDSEEEKTGLAVTVGQAKSV-GKGLQVKAASV-PVK----GSLGQGTAPVL 743
ED S ++D+ G +V++G+ S GK + V + V PV ++ +G L
Sbjct: 550 KEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSL 609
Query: 744 PGKTGPTVTQVKAEKQEDSES-------SEEESDSEEAAASPAQ-----VKTSVKKTQAK 791
P + G VT KA+ + ++ +E + +E AA+P + +K + K
Sbjct: 610 PLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEK 669
Query: 792 ANPAAAR----APSAKGTISAPGKVVTAAAQAKQRSPS--KVKPPVRNPQNSTVLARGPA 845
+P + R S KG + GK +A ++ K SPS KV P S + +
Sbjct: 670 VDPGSCRKAEPLASGKGEPVSLGKADSAPSR-KTESPSLGKVVP------LSLEKTKPSS 722
Query: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPA 903
S + + +A++ G G E +++ S EA +L Q + AA A
Sbjct: 723 SSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQ-------KDLEAAGAER 775
Query: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPA 947
P + AAP P +T + +A + S D+ +A A
Sbjct: 776 SPCP-EAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGA 818
Score = 84.0 bits (206), Expect = 6e-16
Identities = 198/881 (22%), Positives = 313/881 (35%), Gaps = 173/881 (19%)
Query: 171 SETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVST 230
S+ + + P PGM S ++ S + + +S SD P A + S
Sbjct: 48 SQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDG------PRGSLACPSPTCFSP 101
Query: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEES--------------ESSEEG 276
+ESP+++ A G TP+ P + K E +S +SS++
Sbjct: 102 QESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQA 161
Query: 277 SESE--EEAPAGTRS-----QVKASEKILQVRAASAPAKGTP------------------ 311
+ +E P +R KA +IL AP + P
Sbjct: 162 DSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLC 221
Query: 312 -GKGATPAP----PGKAGAV--ASQTKAG----KPEEDSESSSEESSDSEEETPAAKALL 360
K T +P PG V S K + EE S E SE+ P + +
Sbjct: 222 SSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKV 281
Query: 361 QAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPA----VAKAQAGKREEDSQSSSEE 416
SGK S A P + A GKT P + +GK S +
Sbjct: 282 DLVLSGKRDP--GPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAP 339
Query: 417 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR 476
P + A + PA + + P +G + + D+
Sbjct: 340 GSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSG----EGRPVSGHTDTT 395
Query: 477 SSSEESDSDREALAAMNAAQVKP--LGK-------SPQVKPASTMGMGPLGKGAGPVPPG 527
+S++ + + + M++ +V P LGK P++ +GK AG V PG
Sbjct: 396 ASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGK-AGTVSPG 454
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEV-PTAVAPAQEKSLG-----NILQAKPT 581
K P + + ++SSE+ + S G+ P + P +SLG + ++A+P
Sbjct: 455 KEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPA 514
Query: 582 SSPAKGPP---QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP---- 634
+ KG P +KAG VA A +S ++ A +E P + A A P
Sbjct: 515 TG-GKGDPLSSEKAGLVASGKAA------PTASGKAEPLAVGKEDPVSKGKADAGPSGQG 567
Query: 635 -ALKIPQTKACPKKTNTTASAKVAPVRVG-----------------------TQA-PRKA 669
++ I + + P KT S KV PV +G T+A PR +
Sbjct: 568 DSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRAS 627
Query: 670 GTATSPAG-------------SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAK 716
G A +G ++P AG E +SE+ D + + G+ +
Sbjct: 628 GKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGE 687
Query: 717 SVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE-ESDSEEAA 775
V G KA S P + + V+P + EK + S SS + + + +A
Sbjct: 688 PVSLG---KADSAPSRKTESPSLGKVVP---------LSLEKTKPSSSSRQLDRKALGSA 735
Query: 776 ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQ 835
SP + S + + KA P ++ S+ G K + AA + P PP
Sbjct: 736 RSPEGARGSEGRVEPKAEPVSSTEASSLGQ-----KDLEAAGAERSPCPEAAAPP----- 785
Query: 836 NSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG--SSEEESDSEEEAETLAQVKPSGKT 893
GP + + KA + A A P ED+G + + S + Q G
Sbjct: 786 ------PGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSA 839
Query: 894 HQIRAA-LAPAKESPRK-------GAAPTPPGKTGPSAAQA 926
+AA AP+ S R GAA T TGP QA
Sbjct: 840 FSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQA 880
Score = 44.3 bits (103), Expect = 6e-04
Identities = 90/409 (22%), Positives = 143/409 (34%), Gaps = 79/409 (19%)
Query: 91 EEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVAN 150
E+ + T KA PR + G P S KAET+ G+ G + P G+ A
Sbjct: 612 EKGSPVTTTKADPRAS-------GKAQPQS---GGKAETKLPGQEGAAAP----GEAGAV 657
Query: 151 LLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADS------------ 198
L ++P+ S + + +E G K VS G+ADS
Sbjct: 658 CLKKETPQASEKVDPGSCRKAEPLASG---------KGEPVSLGKADSAPSRKTESPSLG 708
Query: 199 -----SSEDTSSSSDETDVEGKP------------SVKPAQVKASSVSTKESPARKAAPA 241
S E T SS ++ K S + KA VS+ E+ +
Sbjct: 709 KVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDL 768
Query: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVR 301
+ +P + A PP R + ++ S E + AGT++ +A V
Sbjct: 769 EAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQAC-----VS 823
Query: 302 AASAPAKGTPGKGAT----------PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEE 351
A +P G G + P+PP + A Q G +E+ S +
Sbjct: 824 VAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDA-GLQVSLGA----AETRSVATGPMTP 878
Query: 352 ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKT----GPAVAKAQAGKRE 407
+ A A + + ++ A + P P + + G T G A+ G
Sbjct: 879 QAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAI 938
Query: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456
+ E + APA P+ +A R+ S + +P GAA PP
Sbjct: 939 QKHLERQIEEHGRQGAPA-PPPAARAGPGRSGS--VRTAPPDGAAKRPP 984
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 93.6 bits (231), Expect = 8e-19
Identities = 183/760 (24%), Positives = 264/760 (34%), Gaps = 100/760 (13%)
Query: 146 KTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSS 205
K V++L+ + +A + + L T E V A A A V +G S +
Sbjct: 20 KVVSDLVGSLESQLAASAAHHHHLAPRTPE---VRAAAAGALGNHVVSG----SPAGAAG 72
Query: 206 SSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK 265
+ EG P P A + P PG P V G PPA + +
Sbjct: 73 AGPAAPAEGAPGAAPEPPPAG----RARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRP 128
Query: 266 PEEESESS-------EEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPA 318
P E S S + E APAG A L RA P G PG G P
Sbjct: 129 PPEGSAGSCAPVPAAAAVAAGPEPAPAGPAK--PAGPAALAARAGPGPGPG-PGPGPGPG 185
Query: 319 PPGKAGAVASQTKAGKPE-EDSESSSEESSDSEEETPAAKALLQAKASGKT-----SQVG 372
P AG A+QT G +S ++ + PAA L A+ T VG
Sbjct: 186 PGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVG 245
Query: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
AA+ PA +P AAPAP A A A + ++ P A P+
Sbjct: 246 AAAPPAPAAPSPPAAPAP-------AAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVP 298
Query: 433 APQVRAASAPAKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSS--EESDSDREAL 489
P A A+ GAAPAP P GPA Q G + + + R
Sbjct: 299 PP------AAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQ 352
Query: 490 AAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSS 549
AA AAQ L S A++M +GP +GA P P V P P G + + + +
Sbjct: 353 AAPPAAQT--LAASGPASTAASMVIGPTMQGALP-SPAAVPPPAPGTPTGLPKGAAGAVT 409
Query: 550 EESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE 609
+ S PTA +L PT + P P +Q P
Sbjct: 410 QSLS-----RTPTATTSGIRATL------TPTVLAPRLPQPPQNPTNIQNFQLPPGMVLV 458
Query: 610 SSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGT-QAPRK 668
SE ++A A M A A PQT P+ T++ PV++ T QAP
Sbjct: 459 RSENGQLLMIPQQALAQMQA----QAHAQPQTTMAPRPATPTSA---PPVQISTVQAP-- 509
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
+P +A S+ + + L + G + G + AS
Sbjct: 510 ---------GTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTAS 560
Query: 729 VPVKGSLGQGTAP-VLPGKT------GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 781
+ ++ GT +PG T T+ VK K S + S +++ + A V
Sbjct: 561 LGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANV 620
Query: 782 K----------------TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825
K TS + ++P P K ++ A ++ +A Q+S
Sbjct: 621 KELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQ 680
Query: 826 KVKPPVRNPQNS-TVLARGPASVPSVGKAVATAAQAQTGP 864
+ PP + T + + + GK AT A P
Sbjct: 681 QPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPP 720
Score = 85.1 bits (209), Expect = 3e-16
Identities = 155/640 (24%), Positives = 226/640 (35%), Gaps = 79/640 (12%)
Query: 268 EESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 327
+E S+ E + A + + +VRAA+A A G +PA G AGA
Sbjct: 18 DEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPA--GAAGAGP 75
Query: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG-- 385
+ G P + E PA +A + G G P SPR+
Sbjct: 76 AAPAEGAP-----------GAAPEPPPAGRA----RPGG-----GGPQRPGPPSPRRPLV 115
Query: 386 -AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAK 444
A PAPP + AG +++ + E AKP+G A A
Sbjct: 116 PAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPG 175
Query: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSP 504
P G P P + GP AAQ G S+ +S A A++ P P
Sbjct: 176 PGPGPGPGPGPGKPAGPGAAQTLNG--------SAALLNSHHAAAPAVSLVNNGPAALLP 227
Query: 505 QVKPAST---------MGMGPLGKGAGPVPPGKVGPATP-SAQVGKWEEDSESSSEESSD 554
KPA+ +G A P PP PA P +A + +
Sbjct: 228 LPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHP 287
Query: 555 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ----KAGPVAVQVKAEKPMDNSES 610
+ AV P G A P +PA G P + GP A A P +ES
Sbjct: 288 AGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAA-AAAPAPGVKAES 346
Query: 611 SEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAG 670
+ +A PAA T A + PA T A T A +P V AP G
Sbjct: 347 PKRVVQAA----PPAAQTLAASGPA----STAASMVIGPTMQGALPSPAAVPPPAP---G 395
Query: 671 TATS-PAGSSPAVAGGTQR-PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAAS 728
T T P G++ AV R P +S + + Q + + Q+
Sbjct: 396 TPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGM 455
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
V V+ GQ ++P + + Q++A+ +++ + +A P Q+ T
Sbjct: 456 VLVRSENGQ--LLMIPQQ---ALAQMQAQAHAQPQTTMAPRPATPTSAPPVQIST----V 506
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 848
QA P AR + I K V+ A Q S + + P PQ ++ G A
Sbjct: 507 QAPGTPIIARQVTPTTII----KQVSQAQTTVQPSATLQRSPGVQPQ---LVLGGAAQTA 559
Query: 849 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVK 888
S+G ATA Q T G++ S + E E + + K
Sbjct: 560 SLG--TATAVQTGTPQRTVPGATTTSSAATETMENVKKCK 597
Score = 50.1 bits (118), Expect = 1e-05
Identities = 119/497 (23%), Positives = 162/497 (32%), Gaps = 124/497 (24%)
Query: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG-------PLG-KGAGP 523
E D + S+ S LAA A ++P+V+ A+ +G P G GAGP
Sbjct: 16 EVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGP 75
Query: 524 VPP--GKVGPATPSAQVGKWEEDSESSSEESSDS------SDGEVPTA--VAPAQEKSLG 573
P G G A G+ S G P A + P E S G
Sbjct: 76 AAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAG 135
Query: 574 N--------ILQAKPTSSPAKGPPQKAGPVAVQVKA----------------EKPMDNSE 609
+ + A P +PA GP + AGP A+ +A KP
Sbjct: 136 SCAPVPAAAAVAAGPEPAPA-GPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGA 194
Query: 610 SSEESSDSA--DSEEAPA-AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666
+ + +A +S A A A++ PA +P K P T P VG AP
Sbjct: 195 AQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPK--PAAPGTVIQ---TPPFVGAAAP 249
Query: 667 RKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKA 726
+ PA +PA P + + T+ + G A
Sbjct: 250 PAPAAPSPPAAPAPAAPAAAPPPPPPAPA---------------TLARPPGHPAGPPTAA 294
Query: 727 ASVPVK------GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
+VP GS G AP P GP + S + AAA
Sbjct: 295 PAVPPPAAAQNGGSAGAAPAPA-PAAGGP------------AGVSGQPGPGAAAAAPAPG 341
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTIS-APGKVVTAAAQAKQRSPSKVKPPVRNPQNSTV 839
VK K +A P AA+ +A G S A V+ Q SP+ V PP P T
Sbjct: 342 VKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPA--PGTPTG 399
Query: 840 LARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA 899
L +G A T + ++T P+ T IRA
Sbjct: 400 LPKGAA-------GAVTQSLSRT--------------------------PTATTSGIRAT 426
Query: 900 LAPAKESPRKGAAPTPP 916
L P +PR P PP
Sbjct: 427 LTPTVLAPR---LPQPP 440
Score = 39.3 bits (90), Expect = 0.018
Identities = 78/364 (21%), Positives = 116/364 (31%), Gaps = 21/364 (5%)
Query: 607 NSESSEES-SDSADSEEAPAAMTAAQAKP-ALKIPQTKACPKKT---NTTASAKVAPVRV 661
NSE E+ SD S E+ A +AA A + P+ +A + + +
Sbjct: 14 NSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGA 73
Query: 662 GTQAPRKAGTATSP----AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKS 717
G AP + +P AG + GG QRP S + G A + +
Sbjct: 74 GPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPA-----GPAPPAAKLRP 128
Query: 718 VGKGLQVKAASVPVKGSLGQGT--APVLPGK-TGPTVTQVKAEKQEDSESSEEESDSEEA 774
+G A VP ++ G AP P K GP +A
Sbjct: 129 PPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGK 188
Query: 775 AASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP 834
A P +T + + A N A AP+ + P ++ A + + P V
Sbjct: 189 PAGPGAAQT-LNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAA 247
Query: 835 QNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTH 894
A P + P+ A AA P + + V P
Sbjct: 248 APPAPAAPSPPAAPA---PAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQ 304
Query: 895 QIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQD 954
+A A +P G G+ GP AA A + S + PAA T A
Sbjct: 305 NGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAAS 364
Query: 955 QESS 958
+S
Sbjct: 365 GPAS 368
>gi|226509740 SR-related CTD-associated factor 1 [Homo sapiens]
Length = 1312
Score = 90.5 bits (223), Expect = 7e-18
Identities = 226/1052 (21%), Positives = 354/1052 (33%), Gaps = 215/1052 (20%)
Query: 41 AQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAK 100
A P DIY + T E A E + T + S S EEEE E E +
Sbjct: 219 APPAPRFDIYDPFHPTDEAYSPPPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEE 278
Query: 101 ATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLS-----GK 155
+E+ + E E ++ + + G N LS +
Sbjct: 279 E--------------------EEEDEEEEEGLSQSISRISETLAGIYDDNSLSQDFPGDE 318
Query: 156 SPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSS-------- 207
SPR A+P+ T + S A GA + V +A++ E S
Sbjct: 319 SPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEACREGKVSVEVVTAGGAA 378
Query: 208 --------DETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
++++E V+P + ++S R A P P TP + PP
Sbjct: 379 LPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTPA--ASATPTAQPLPQPP 436
Query: 260 AKRAKKPEE----ESESSEEGS---ESEEEAPAGTRSQVK-----ASEKILQVRA----- 302
A RA + ++ +ES EG+ + E APA + + KIL R
Sbjct: 437 APRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLDLRRKILTQRRERYRQ 496
Query: 303 ---------ASAPAKGTPGK---------------------GATPAPPGKAGAVASQ--- 329
A A A G P + G PAPP A S+
Sbjct: 497 RSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQPAPPAPASPWDSKKHR 556
Query: 330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA 389
++ KP + SS+ S S + + + ++ + + S + R+ A+P
Sbjct: 557 SRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRRSASPP 616
Query: 390 PPGKTGPAVAKAQ----------AGKREEDSQSSSEE--SDSEEEAPAQAKPSGKAPQVR 437
P + + + + + K+++ S+S E+ D E+APA A P +
Sbjct: 617 PATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGS---- 672
Query: 438 AASAPAKESPRKGAAP-------------------------APPRKTGPAAA-------- 464
S ++S R+GA P + PR PA A
Sbjct: 673 -TSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVL 731
Query: 465 --------QVQVGKQEEDSR---------SSSEESDSDREALAAMNAAQVKPLGKSPQVK 507
+ + GK + R SSS E S R+AL + + + +
Sbjct: 732 YDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRS 791
Query: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
+GP P V + S SSS S S ++ + VA
Sbjct: 792 SKKARPPKESAPSSGPPPKPPVSSGSGS-----------SSSSSSCSSRKVKLQSKVAVL 840
Query: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
+ + + AK +S AG ++ VK + ++ + + A +E A AA
Sbjct: 841 IREGVSSTTPAKDAAS--------AGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAA- 891
Query: 628 TAAQAKPALKIPQTKACPKKTN-TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGT 686
KP + KA KKT T K + R ++ +G + + A
Sbjct: 892 -PGSTKPKKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSC 950
Query: 687 QRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGK 746
+ A + E S S EE+ + K+ + S V S LP +
Sbjct: 951 SQAAGTKGAEETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEE 1010
Query: 747 -TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 805
T + AE++E+ E EEE + EE TS A A + APSA T
Sbjct: 1011 ATEEAGVRGGAEEEEEEEEEEEEEEEEEEQQPATTTATST------AAAAPSTAPSAGST 1064
Query: 806 ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
G A++ Q + PP+ P N PA V V E
Sbjct: 1065 AGDSGAEDGPASRVSQL--PTLPPPM--PWNL------PAGVDCTTSGVLALTALLFKME 1114
Query: 866 EDSGSSEEESDSEEEA--ETLAQVKPSGKTHQIRA------ALAPAKES-------PRKG 910
E + +S ++ +A + L+ KP A L P S P G
Sbjct: 1115 EANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGG 1174
Query: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSD 942
TPP TG AA + K++ S SS D+D
Sbjct: 1175 CGSTPPTPTG-LAATSDKREGSSSSEGRGDTD 1205
Score = 67.4 bits (163), Expect = 6e-11
Identities = 163/752 (21%), Positives = 249/752 (33%), Gaps = 148/752 (19%)
Query: 73 AKKTRVSD--PISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETE 130
+KK R D P S + SS +++T R + + G S +EK +
Sbjct: 552 SKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRSRSREKRRRRRR 611
Query: 131 KAGKTGNSMPHPATGKTVANLLS----------GKSPRKSAEPSANTTLVSETEEEGSVP 180
A P PAT + ++ G +K S + E+ P
Sbjct: 612 SAS------PPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAP 665
Query: 181 AFGAAAKPGMVSAGQADSSSEDT--SSSSDETDVEGKPSVKPAQVKASSVSTKESPARKA 238
A G S G DS S D TD + + V S P+
Sbjct: 666 A---PPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAP 722
Query: 239 APAPGKV-----GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG---TRSQ 290
A +P + ++ + +GG R + S SS S +A G R +
Sbjct: 723 ASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDRDR 782
Query: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
+ ++ + A P + P G P PP +G S SSS SS S
Sbjct: 783 DRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSG--------------SGSSSSSSSCSS 828
Query: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS 410
K LQ+K + + +++ PAK+ AA A G G ++ + +
Sbjct: 829 R-----KVKLQSKVAVLIREGVSSTTPAKD-----AASAGLGSIGVKFSRDRESRSPFLK 878
Query: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA-PAPPRK-------TGPA 462
++ + AP KP K +V+A + K KG P+ RK +G +
Sbjct: 879 PDERAPTEMAKAAPGSTKP--KKTKVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGS 936
Query: 463 AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522
QV + K + DS S +A A + G+ K ST
Sbjct: 937 GGQVSLKKSKADSCS---------QAAGTKGAEETSWSGEERAAKVPST----------- 976
Query: 523 PVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582
PP K P P+ DS + E S
Sbjct: 977 --PPPKAAPPPPALTPDSQTVDSSCKTPEVSFL--------------------------- 1007
Query: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
P + V+ AE+ + E EE + + E+ PA TA A P T
Sbjct: 1008 -----PEEATEEAGVRGGAEE--EEEEEEEEEEEEEEEEQQPATTTATSTAAAA--PSTA 1058
Query: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTA--TSPAGSSPAVAGGTQRPA-----EDSSS 695
T + A+ P +Q P PAG +G A E+++
Sbjct: 1059 PSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANL 1118
Query: 696 SEESDSEEEKTGLAVTVGQAKSVGKG-LQVKAASVPVKGSLGQGTAP---VLPGK----- 746
+ + ++E L Q S K + PV SLG P +LPG
Sbjct: 1119 ASRAKAQE----LIQATNQILSHRKPPSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGG 1174
Query: 747 ---TGPTVTQVKA--EKQEDSESSEEESDSEE 773
T PT T + A +K+E S SSE D+++
Sbjct: 1175 CGSTPPTPTGLAATSDKREGSSSSEGRGDTDK 1206
Score = 58.9 bits (141), Expect = 2e-08
Identities = 132/686 (19%), Positives = 210/686 (30%), Gaps = 108/686 (15%)
Query: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
PAPP A + AS + + P S S P A T + +
Sbjct: 184 PAPP-PAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEA-YSPP 241
Query: 377 PAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV 436
PA E P + A + + EE+ + EE D EEE S + +
Sbjct: 242 PAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISETL 301
Query: 437 R--------AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSR----------SS 478
+ P ESPR A P P QV + + R +
Sbjct: 302 AGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAEA 361
Query: 479 SEESDSDREALAAMNAAQVKPL---GKS---------PQVKPASTMGM-GPLGKGAGPVP 525
E E + A AA PL G S P+ +P + + P G+ A P P
Sbjct: 362 CREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPTP 421
Query: 526 PGKVGPAT---PSAQVGKWEEDSESSSEESSDSSDGEV------PTAVAPAQEKSLGNI- 575
P P + E + S + +G + P PA + G +
Sbjct: 422 AASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGLD 481
Query: 576 -------------LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEE 622
Q P+ +PA P AGP + + + E+ E +S S+ ++
Sbjct: 482 LRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQP 541
Query: 623 APAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV 682
AP A A P + S P + + R+ + S + S+
Sbjct: 542 APPA---------------PASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRR 586
Query: 683 AGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
+ T R S S + + + A+ P S
Sbjct: 587 SRSTDRRRGGSRRSRSREKRRRR-----------------RRSASPPPATSSSSSSRRER 629
Query: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT-SVKKTQAKANPAAARAPS 801
GK K +K+ S + D E A +PA + S + A PS
Sbjct: 630 HRGKHRDGGGSKKKKKRSRSRGEKRSGDGSEKAPAPAPPPSGSTSCGDRDSRRRGAVPPS 689
Query: 802 AKG----TISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA 857
+ + A + +T K P +P+ + S G +
Sbjct: 690 IQDLTDHDLFAIKRTITVGRLDKSDPRGPSPAPASSPKREVLYDSEGLSGEERGGKSSQK 749
Query: 858 AQAQTGPEEDSGSSEEESDSEEEAE----TLAQVKPSGKTHQIRAALAPAKESPRKGAAP 913
+ ++G S SS E+ + + + + + + A P + +P G P
Sbjct: 750 DRRRSGAASSSSSSREKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPP 809
Query: 914 TPPGKTGPSAAQAGKQDDSGSSSEES 939
PP +G SGSSS S
Sbjct: 810 KPPVSSG-----------SGSSSSSS 824
Score = 55.8 bits (133), Expect = 2e-07
Identities = 109/475 (22%), Positives = 161/475 (33%), Gaps = 79/475 (16%)
Query: 58 ELGRKRKAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGAD 116
E G +RKA + + R D +S+ + +E A + P ++S + S +
Sbjct: 765 EKGSRRKALDGGDRDRDRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSS 824
Query: 117 LPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE 176
SS K K +++ + G S PA A L S + S + + + + E
Sbjct: 825 SCSSRKVKLQSKVAVLIREGVSSTTPAKDAASAGLGS-IGVKFSRDRESRSPFLKPDER- 882
Query: 177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
P A A PG S+ +T V+ K K + K + TK S R
Sbjct: 883 --APTEMAKAAPG--------------STKPKKTKVKAKAGAK--KTKGTKGKTKPSKTR 924
Query: 237 KAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEK 296
K + G G QV KK + +S S G++ EE +
Sbjct: 925 KKVRSGGGSGGSGGQVS---------LKKSKADSCSQAAGTKGAEETSWSGEERAAKVPS 975
Query: 297 ILQVRAASAPAKGTPGKGATPAP---------PGKAGAVASQTKAGKPEEDSESSSEESS 347
+AA P TP + P +A A + EE+ E EE
Sbjct: 976 TPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGGAEEEEEEEEEEEEEE 1035
Query: 348 DSEEETP--------AAKALLQAKASGKTS-QVGAASAPAKESPRKGAAPAPPGKTGPA- 397
+ EE+ P AA A A ++G T+ GA PA + P P PA
Sbjct: 1036 EEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQLPTLPPPMPWNLPAG 1095
Query: 398 ---------VAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP-QVRAASAPAKES- 446
A K EE + +S ++ +A Q K P + AP S
Sbjct: 1096 VDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKPPSSLGMTPAPVPTSL 1155
Query: 447 ---------------PRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR 486
P G PP TG AA + E S SS D+D+
Sbjct: 1156 GLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAA----TSDKREGSSSSEGRGDTDK 1206
Score = 50.4 bits (119), Expect = 8e-06
Identities = 89/386 (23%), Positives = 141/386 (36%), Gaps = 47/386 (12%)
Query: 601 AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
A P +S SS S + S +P A PA P+ T + P
Sbjct: 185 APPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSPPP-- 242
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGK 720
AP + P GS+P+ + GT P E+ EE + EEE G ++S+ +
Sbjct: 243 ----APEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDE--EEEEGLSQSISR 296
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
+ A + SL Q PG P + + + + + DS A + +
Sbjct: 297 -ISETLAGIYDDNSLSQD----FPGDESPR-PDAQPTQPTPAPGTPPQVDSTRADGAMRR 350
Query: 781 VKTSVKKTQAKA---NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNS 837
+ V T+A+A + +A G P + ++ ++ ++ P P+ +
Sbjct: 351 -RVFVVGTEAEACREGKVSVEVVTAGGAALPPPLLPPGDSEIEE---GEIVQPEEEPRLA 406
Query: 838 TVLAR--GPASVPSVGKAVATAAQ------AQTGPE-EDSGSSEEESDSEEEAET-LAQV 887
L R G A+ P+ + AQ A PE +D S ESD E + L +
Sbjct: 407 LSLFRPGGRAARPTPAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEP 466
Query: 888 KPS--------GKTHQIRAALAPAKE-----SPRKGAAPTPPGKTGPSAAQAGKQD--DS 932
P+ G R L +E SP AP P GP + +++ S
Sbjct: 467 APAPPAADSRWGGLDLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRS 526
Query: 933 GSSSE-ESDSDGEAPAAVTSAQDQES 957
G + E S S G PA A +S
Sbjct: 527 GEAKEAASSSSGTQPAPPAPASPWDS 552
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 87.8 bits (216), Expect = 4e-17
Identities = 139/876 (15%), Positives = 318/876 (36%), Gaps = 48/876 (5%)
Query: 74 KKTRVSDPISTSESS-EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKA 132
K + DP S+ ES+ ++ +E++ ++ AS NS K+ K
Sbjct: 458 KSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSD--------ESKDNGNGSDSKG 509
Query: 133 GKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVS 192
+ +S T + +N +G + + S + S++ + S + ++ S
Sbjct: 510 AEDDDSDSTSDTNNSDSNG-NGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD-----S 563
Query: 193 AGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQV 252
+ +DS S D++SSSD + S + S ++ +S + D +
Sbjct: 564 SDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSK 623
Query: 253 KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
+ + + + S S+S + + + S S +S + +
Sbjct: 624 SDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683
Query: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
++ + + +S++ DS+SS +SSDS + + S +S
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSS--DSSDSSNSNSSDSDSSNSSDSSDSSNSS 741
Query: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
+S + S ++ + + + DS +SS+ +DS + + +
Sbjct: 742 DSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSS 801
Query: 433 APQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA-A 491
+ S+ + +S ++ + ++ DS SS+ SDSD + +
Sbjct: 802 DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Query: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS--- 548
N++ S +S + + S+ + S+SS
Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921
Query: 549 -SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDN 607
S ESS+SSD + + + + S + SS + + N
Sbjct: 922 DSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSN 981
Query: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667
S S +SSDS+DS ++ + ++ + + + +N++ S+ + + +
Sbjct: 982 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041
Query: 668 KAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAA 727
+ ++ S S + + + ++ S SS+ SDS + + S +
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSD 1101
Query: 728 SVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKK 787
S + + + DS +S + SDS +++ S +S
Sbjct: 1102 S----------------SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145
Query: 788 TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV 847
++++ ++ + S+ + S+ + ++ + S S + +S+ + S
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1205
Query: 848 PSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESP 907
S ++ + + DS S + SDS E +++ S ++ + + +S
Sbjct: 1206 DSSD----SSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNS-----SDSSDSS 1256
Query: 908 RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG 943
+ + S +++G +++GS S +SDS+G
Sbjct: 1257 DSSDSTSDSNDESDSQSKSGNGNNNGSDS-DSDSEG 1291
Score = 78.6 bits (192), Expect = 3e-14
Identities = 102/633 (16%), Positives = 249/633 (39%), Gaps = 23/633 (3%)
Query: 79 SDPISTSESSEEEEEAEA-ETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGN 137
SD S+S+SS + +++ +++ ++ S++SS + S ++++ + + +
Sbjct: 675 SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDS 734
Query: 138 SMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE--EGSVPAFGAAAKPGMVSAGQ 195
S ++ + ++ S S + S+N++ S++ + + S + + + S+
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDS 794
Query: 196 ADSS-SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKG 254
+DSS S D+S+SSD +D + SS S+ S + ++ + D + G
Sbjct: 795 SDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDS----SDSSDSSDG 850
Query: 255 GALPPAKRA--KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
+ R+ + S+SS+ + S+ + + +S+ ++ + + +
Sbjct: 851 SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910
Query: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
+ + + S + S+S +SSDS + + ++ + + +S +
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ-AKPSG 431
+ S+ + +S ++ + + + DS SS+ SDS + + + S
Sbjct: 971 SNSSDSSDS--SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
+ +S + S ++ + ++ DS SS+ SDS + ++
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Query: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS-SE 550
++ S + + + ++ S+ S+SS S
Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148
Query: 551 ESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSES 610
ESSDSSD + + + + S + SS + + + D+S+S
Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD-------SSDSSDSSDS 1201
Query: 611 SE--ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
S+ +SSDS+DS ++ + ++ + + ++ ++++ S+ + + +
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261
Query: 669 AGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
+ + S G ++ S SE SDS
Sbjct: 1262 TSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDS 1294
Score = 77.4 bits (189), Expect = 6e-14
Identities = 98/643 (15%), Positives = 236/643 (36%), Gaps = 28/643 (4%)
Query: 64 KAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE 123
K+E D++ K+ SD S+ S + + ++ ++ S++SS + SS
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687
Query: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
+ ++ + + +S ++ ++ + S S+N++ S++
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPG 243
++ S S+S D+S SSD +D + + ++S + +S +
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS 807
Query: 244 KVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAA 303
D + + + + + S+ S ++ G+ S +
Sbjct: 808 DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSD------------S 855
Query: 304 SAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK 363
S + + ++ + + +S + +S SS+ S+ S+ ++ + +
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Query: 364 ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA 423
S +S +S + S ++ + + + DS +SS+ SDS
Sbjct: 916 DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSD 975
Query: 424 PAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483
+ + S + +S + S ++ + ++ DS +SS+ SD
Sbjct: 976 SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 1035
Query: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543
S + ++ ++ S + + + ++ S+ +
Sbjct: 1036 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSD 1095
Query: 544 DSESS-SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE 602
S+SS S +SSDSSD + + + S + SS + +
Sbjct: 1096 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS---------- 1145
Query: 603 KPMDNSESSE--ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR 660
D+SESS+ +SSDS+DS ++ + ++ + + + ++++ S+ +
Sbjct: 1146 ---DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202
Query: 661 VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
+ + + ++ S S + + + E S SS+ SDS +
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSD 1245
Score = 76.3 bits (186), Expect = 1e-13
Identities = 145/915 (15%), Positives = 322/915 (35%), Gaps = 52/915 (5%)
Query: 57 SELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD 116
S +G+ ++E + K+ ++ S EE A + R+ T
Sbjct: 293 SSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRES 352
Query: 117 LPSSMKEKAKAETEKAGKT---GNSMPHPATG-----KTVANLLSGKSPRKSAEPSANTT 168
+ ++ET GK+ G + P++G K V GK +
Sbjct: 353 KRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKG 412
Query: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
V E ++ G ++PG G +++ S+ S D D + K S++ +S
Sbjct: 413 NVKTQGEVVNIEGPGQKSEPGN-KVGHSNTGSDSNSDGYDSYDFDDK-SMQGDDPNSSDE 470
Query: 229 STKESPARKAAPAPGKV-GDVT----PQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
S A + GD + G +K A+ + +S S S+S
Sbjct: 471 SNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNG 530
Query: 284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSS 343
G K+ GKG + + + +S + DS+SS
Sbjct: 531 NNGNDDNDKSDS----------------GKGKSDSSDSDSSD-SSNSSDSSDSSDSDSSD 573
Query: 344 EESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQA 403
SS + + + + S +S +S + S ++ + K+ + K+++
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS--KSES 631
Query: 404 GKREEDSQSSSEESDSEEEAP-AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA 462
+ DS+S S +S+S + + + + S + +S + S ++ +
Sbjct: 632 DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 463 AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522
++ + DS SS+ SD + N++ S +++ +
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 523 PVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582
++ S+ + S+SS +SS+SSD + + + + S + S
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSSDSS--DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 583 SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
S + + +S +S +SSDS+DS + + ++ ++ + +
Sbjct: 810 SDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869
Query: 643 ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSE 702
+ ++ +S + + +S + SS + + +SS S ES +
Sbjct: 870 SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929
Query: 703 EEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDS 762
+ + + + + S +S S ++ + + + DS
Sbjct: 930 SDNSNSSDSSNSSDSSDSS-DSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988
Query: 763 ESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQR 822
S + SDS +++ S +S + ++ ++ + S+ + S+ + ++ +
Sbjct: 989 SDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS 1048
Query: 823 SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAE 882
S S + +S+ + S S ++ +++ DS +S + SDS + ++
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDSSD----SSDSSESSDSSDSSNSSDSSDSSDSSD 1104
Query: 883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSD 942
+ S + S ++ + ++ + DS SSE SDS
Sbjct: 1105 SSDSSDSSDSSDS----------SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154
Query: 943 GEAPAAVTSAQDQES 957
+ ++ +S S
Sbjct: 1155 DSSDSSDSSDSSDSS 1169
Score = 74.7 bits (182), Expect = 4e-13
Identities = 154/967 (15%), Positives = 341/967 (35%), Gaps = 90/967 (9%)
Query: 55 QTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEA----EAETAKATPRLASTNS 110
Q ++G E+ A +Q +V+ +++++ +E E E T++ TP++ S +
Sbjct: 163 QNGDVGDAGHNEDVAVVQEDGPQVAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRN 222
Query: 111 SVLGADLPSSMKEKAKAETEKAGKTGNSMPHP-------------ATGKTVANLLSGKSP 157
A++ E A + +GN GK +N G+
Sbjct: 223 GTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEG 282
Query: 158 RKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS 217
+ + + + + + + P G S SE+ S+ E + G
Sbjct: 283 QDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDN--GSQR 340
Query: 218 VKPAQV-------KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEES 270
++ Q + + TKES A GK D ++KG P+ + +E
Sbjct: 341 IEDTQKLNHRESKRVENRITKESETH----AVGKSQDKGIEIKG----PSSGNRNITKEV 392
Query: 271 ESSEEGSESE-EEAPAGTRSQVKASEKILQVRAASAPAK--GTPGKGATPAPPGKAGAVA 327
EG E + + + VK +++ + ++ G T + G +
Sbjct: 393 GKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDS 452
Query: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
+ D +SS+ES+ +++ +++ +S G AS + ES G
Sbjct: 453 YDFDDKSMQGDDPNSSDESNGNDDAN--------SESDNNSSSRGDASYNSDESKDNGNG 504
Query: 388 PAPPG-----------------------------KTGPAVAKAQAGKREE-DSQSSSEES 417
G K+ K+ + + DS +SS+ S
Sbjct: 505 SDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS 564
Query: 418 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
DS + + + S + + S+ + +S ++ + ++ DS+S
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 478 SSEESDSDR-EALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
S +S+SD ++ + +++ S + + + ++ S+
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS 684
Query: 537 QVGKWEEDSESS-SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPV 595
+ S+SS S ESSDSSD + + + + S N + ++S +
Sbjct: 685 NSSDSSDSSDSSNSSESSDSSDSSDSDS-SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743
Query: 596 AVQVKAEKPMDNSESSEES--SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653
+ + D+S+SS+ S SDS+DS ++ + ++ + + + +N++ S
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803
Query: 654 AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG 713
+ + + ++ S+ + + + ++ S+SS+ SDS + G
Sbjct: 804 SN-------SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS 856
Query: 714 QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEE 773
+S S ++ + DS S SDS +
Sbjct: 857 NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD 916
Query: 774 AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRN 833
++ S ++S + ++ ++ + S+ + S+ + ++ + S S +
Sbjct: 917 SSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEE-DSGSSEEESDSEEEAETL--AQVKPS 890
+S +S S + ++ + + DS S SDS +++ + S
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 891 GKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT 950
+ + + S ++ + ++ + DS SSE SDS + ++ +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDS 1096
Query: 951 SAQDQES 957
S S
Sbjct: 1097 SDSSDSS 1103
Score = 36.2 bits (82), Expect = 0.15
Identities = 39/220 (17%), Positives = 93/220 (42%), Gaps = 10/220 (4%)
Query: 68 DAALQAKKTRVSDPISTSESSEEEEEAEA----ETAKATPRLASTNSSVLGADLPSSMKE 123
D++ ++ + SD ++S+SS+ + +++ +++ ++ S+NSS SS
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1136
Query: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFG 183
+ ++ + + +S ++ + ++ S S + S+N++ S++ +
Sbjct: 1137 DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1196
Query: 184 AAAKPGMVSAGQADSSSEDTSSSSDETD----VEGKPSVKPAQVKASSVSTKESPARKAA 239
++ S S S D+S SSD +D + S + SS S+ S + ++
Sbjct: 1197 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSS 1256
Query: 240 PAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSES 279
+ D + + + +S+S EGS+S
Sbjct: 1257 DSSDSTSDSNDE--SDSQSKSGNGNNNGSDSDSDSEGSDS 1294
Score = 30.8 bits (68), Expect = 6.3
Identities = 20/111 (18%), Positives = 47/111 (42%), Gaps = 3/111 (2%)
Query: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
GK + ++ + + +S S + SDS+ + S + ++ + + +S
Sbjct: 543 GKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSS 602
Query: 911 AAPTPPGKTGPSAAQAG---KQDDSGSSSEESDSDGEAPAAVTSAQDQESS 958
+ + S + K D S S S+ SDSD ++ ++ +++ D +
Sbjct: 603 DSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653
>gi|91982772 mucin 17 [Homo sapiens]
Length = 4493
Score = 87.0 bits (214), Expect = 7e-17
Identities = 188/911 (20%), Positives = 303/911 (33%), Gaps = 136/911 (14%)
Query: 67 EDAALQAKKTRVSDPISTS-ESSEEEEEAEAETAK-ATPRLASTN-SSVLGADLPSSMKE 123
E + L S P++TS E+S AE + + +TP ST +S+L + LP + E
Sbjct: 2708 EASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSE 2767
Query: 124 KAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEE-GSVPAF 182
+ T T P T T A+ SP + S T+ SET S+P
Sbjct: 2768 ASTVST-----TAVDTSIPVTTSTEAS----SSPTTAEVTSMPTSTPSETSTPLTSMPVN 2818
Query: 183 G---AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAA 239
A+++ G +S D+S+ T+S T P+ V S +++ S +
Sbjct: 2819 HTPVASSEAGTLSTTPVDTSTPVTTS----TKASSSPTTAEGIVVPISTASEGSTLLTSI 2874
Query: 240 PAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA-----PAGTRSQVKAS 294
P TP A + +S EGS S A P T S+V S
Sbjct: 2875 PV-----STTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEV--S 2927
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEE-SSDSEEET 353
+ + ++ P G+ + P V + +A +E +S S+ E T
Sbjct: 2928 TPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRT 2987
Query: 354 PAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS 413
P + + ++ P S + P + P +A SS
Sbjct: 2988 PL-------------TSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEA--------SS 3026
Query: 414 SEESDSEEEAPAQAKPSGKAP--QVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQ 471
S + P G P + ++ P + P P +V
Sbjct: 3027 SPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSS 3086
Query: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPA-STMGMGPLGKGAGPVPPGKVG 530
+ +S + E + P+ +P A ST+ P+
Sbjct: 3087 PTPAEGTSMPISTYSEGSTPLTGV---PVSTTPVTSSAISTLSTTPVDTST--------- 3134
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQE----KSLGNILQAKP------ 580
P T S + SE +S +S S+G P P S + L A P
Sbjct: 3135 PVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTP 3194
Query: 581 ---------------TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625
TS P P + P+ + P+ +SE+S S+ DS
Sbjct: 3195 VTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLT 3254
Query: 626 AMTAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT---- 673
T A + P P + P + ++ VA T + A T+T
Sbjct: 3255 TSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTT 3314
Query: 674 -SPAGSSPAVAGGTQRPAEDSS-----------------SSEES--DSEEEKTGLAVTVG 713
S A SSP +A GT P S SSE S + T VT
Sbjct: 3315 YSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTS 3374
Query: 714 QAKSVGKGLQVKAASVPVKGSLGQGTAPV--LPGKTGPTV-TQVKAEKQEDSESSEEESD 770
S+ + S+P S +GT P+ +P T P V ++V +S+ +
Sbjct: 3375 TEASLSP-TTAEGTSIPT-SSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTT 3432
Query: 771 SEEAAASP--AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK 828
S EA++SP A+ + T ++ + + P + +++ + +P
Sbjct: 3433 STEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTS 3492
Query: 829 PPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP---EEDSGSSEEESDSEEEAETLA 885
P + + + P S G T T P E S S DS + +
Sbjct: 3493 SPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSS 3552
Query: 886 QVKPSGKTHQI 896
Q S T Q+
Sbjct: 3553 QASSSPATLQV 3563
Score = 83.2 bits (204), Expect = 1e-15
Identities = 163/841 (19%), Positives = 281/841 (33%), Gaps = 106/841 (12%)
Query: 106 ASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSA 165
A + S D + + +A + G SMP G+ G +P S S
Sbjct: 881 AISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGE-------GSTPLTSMPDST 933
Query: 166 NTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
+ SE + P + A + +++E TS + T EG + V
Sbjct: 934 TPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTS-TPSEGTTPLTSTPVSH 992
Query: 226 SSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPA 285
+ V+ E+ P T P A+ P + + EGS P
Sbjct: 993 TLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMP---TSTPSEGSTPLTRMPV 1049
Query: 286 GTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEE 345
T + V +SE ++ TP +TP + A +S T A + + SE
Sbjct: 1050 ST-TMVASSE--------TSTLSTTPADTSTPVTT-YSQASSSSTTADGTSMPTSTYSEG 1099
Query: 346 SSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP----------APPGKTG 395
S+ + + ++ ++AS ++ S P S ++P +PP +
Sbjct: 1100 STPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEGT 1159
Query: 396 PAVAKAQAGKR----EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA 451
+A E + S+ DS+ + + S P S P +P + +
Sbjct: 1160 TPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTS-TPGERS 1218
Query: 452 APA---PPRKTGPAAAQVQVGKQEEDSRS-----SSEESDSDREALAAMNAAQVKPLGKS 503
P P R T A+++ S S+E S S A G +
Sbjct: 1219 TPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGST 1278
Query: 504 --PQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP 561
+ ++T+ P P GP S +V +E +S +S S+G P
Sbjct: 1279 LLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTP 1338
Query: 562 TAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE 621
P + + A+ + + P+DNS S+++ S
Sbjct: 1339 LTSIPVNTTLVASS--------------------AISILSTTPVDNSTPVTTSTEACSSP 1378
Query: 622 EAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPA 681
+ + P+ + P T S++ + + GT ++ A SSP
Sbjct: 1379 TTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPT 1438
Query: 682 VAGG----TQRPAEDSS-------SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
A G T P+E + S+ + E T V V V ++ P
Sbjct: 1439 TAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSSSPTP 1498
Query: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKK-TQ 789
+G+ A P + +T + S ++ S+ + +PA T V +Q
Sbjct: 1499 AEGT---SIAISTPSEGSTALTSIPV-----STTTVASSEINSLSTTPAVTSTPVTTYSQ 1550
Query: 790 AKANPAAARAPSAKGTISAPGK------------VVTAAAQAKQRSP--SKVKPPVRNPQ 835
A ++P A S + + + G VV++ A +P SK +
Sbjct: 1551 ASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEA 1610
Query: 836 NSTVLARGPA---SVPSVGKAVATAAQAQTGP---EEDSGSSEEESDSEEEAETLAQVKP 889
+S+ A G + S PS G + T+ T P E S S DS T +V
Sbjct: 1611 SSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSS 1670
Query: 890 S 890
S
Sbjct: 1671 S 1671
Score = 81.6 bits (200), Expect = 3e-15
Identities = 176/914 (19%), Positives = 307/914 (33%), Gaps = 103/914 (11%)
Query: 70 ALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAET 129
A + T + S SE + TP ++S S++ + +S AE
Sbjct: 1374 ACSSPTTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEA 1433
Query: 130 EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG 189
+ T + P + + GK+P KS S SE + P +
Sbjct: 1434 TSSPTTAEGISIPTSTPS-----EGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVT 1488
Query: 190 MVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVT 249
+ + + +E TS + T EG ++ V ++V++ E + PA VT
Sbjct: 1489 STAVSSSPTPAEGTSIAIS-TPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTST-PVT 1546
Query: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKIL---------QV 300
+ + P A ++ + EGS P T V + L QV
Sbjct: 1547 TYSQASSSPTT--ADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQV 1604
Query: 301 RAASAPAKGTPGKGA-----TPAP--PGKAGAVASQTKAGKPEEDSESSSEESSDS---- 349
A++ + T +G+ TP+ P S T PE + S++ S+S
Sbjct: 1605 TASTEASSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVIT 1664
Query: 350 -----EEETPAAKALLQAKA--SGKT--SQVGAASAPAKESPRKGAAPAPPGKTGPAVAK 400
TPA + G+T + + + P S + P + P
Sbjct: 1665 STEVSSSPTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTS 1724
Query: 401 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP--QVRAASAPAKESPRKGAAPAPPRK 458
+A S ++SE + P++ G P + ++ P S + P
Sbjct: 1725 TEA----RSSPTTSEGTSMPNSTPSE----GTTPLTSIPVSTTPVLSSEASTLSATPIDT 1776
Query: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
+ P + + +S + + E + + + V + AST+ P+
Sbjct: 1777 STPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANS--EASTLSTTPVD 1834
Query: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
+ P S V +E +S +S S+G P ++ +
Sbjct: 1835 SNS---------PVVTSTAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVAS---- 1881
Query: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
T++ + P + PV + S +AD P + T + +P L
Sbjct: 1882 SETNTLSTTPAVTSTPVTTYAQVSS----------SPTTADGSSMPTS-TPREGRPPLT- 1929
Query: 639 PQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
+ P T T AS+++ + R T S A SSP A GT P S
Sbjct: 1930 ----SIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGST 1985
Query: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG-----PTVTQ 753
+ + V +A ++ S P S ++P G T P+
Sbjct: 1986 PLTSMPLSTTLVVSSEASTL--STTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERT 2043
Query: 754 VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV 813
S + S+ + +P KT V + ++ A A S TISAP +
Sbjct: 2044 TPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSM--TISAPSE-- 2099
Query: 814 TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEE 873
S PV +P+ ST L+ P S V T+ + + P G+S +
Sbjct: 2100 ---GSPLLTSIPLSTTPVASPEAST-LSTTPVDSNS---PVITSTEVSSSPIPTEGTSMQ 2152
Query: 874 ESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
S + L + P T +A++ +P + P T + A++ G
Sbjct: 2153 TSTYSDRRTPLTSM-PVSTTVVASSAISTLSTTPVDTSTPV----TNSTEARSSPTTSEG 2207
Query: 934 SSSEES-DSDGEAP 946
+S S S+G P
Sbjct: 2208 TSMPTSTPSEGSTP 2221
Score = 78.6 bits (192), Expect = 3e-14
Identities = 163/915 (17%), Positives = 297/915 (32%), Gaps = 135/915 (14%)
Query: 79 SDPISTSE--SSEEEEEAEAETAKATP-----RLASTNSSVLGADLPSSMKEKAKAETEK 131
S P+ST+ SSE + +TP +++S+ ++ G+ +P+S + +
Sbjct: 1871 SIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRPPLTS 1930
Query: 132 AGKTGNSMPHPATGKTVANLLSGKSP-----RKSAEPSA--NTTLVSETEEEGSVPAFGA 184
+ ++ L ++P + S+ P+ T++ + EGS P
Sbjct: 1931 IPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSM 1990
Query: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK 244
+V + +A + S +S + S P +S+ T +P+ + P G
Sbjct: 1991 PLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTS-TPSERTTPLAGM 2049
Query: 245 VGDVTPQV--KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
T V +G L K + + + S + E + + + S + +
Sbjct: 2050 PVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPL 2109
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSD-SEEETPAAKALLQ 361
++ P + P V + T+ +E +S ++S S+ TP L
Sbjct: 2110 STTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTP-----LT 2164
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421
+ T +A + +P + P +A++ + S + SE
Sbjct: 2165 SMPVSTTVVASSAISTLSTTPVDTSTPVTNS------TEARSSPTTSEGTSMPTSTPSEG 2218
Query: 422 EAPAQAKPSGKAPQVRA-----------ASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
P + P P V + S P S ++P T + + G
Sbjct: 2219 STPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGT 2278
Query: 471 --------------QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP 516
E S S+ DS+ + A+ P + + P ST G
Sbjct: 2279 TPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSM-PTSTSSEGN 2337
Query: 517 LGKGAGPV----------------PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
PV P P T +Q G ++ +S +S S+G
Sbjct: 2338 TPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGST 2397
Query: 561 PTAVAPAQE--------------------------KSLGNILQAKPTSSPAKGPPQKAGP 594
P P ++ + A+ TS P P + P
Sbjct: 2398 PLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTP 2457
Query: 595 VAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASA 654
+A + P+ +SE+ S+ D+ T A + P + P T + S
Sbjct: 2458 LASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTTA--EDIVVPISTASEGST 2515
Query: 655 KVAPVRVGTQ---APRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
+ + V T +P + +T+P S+ V +S+E S S G ++
Sbjct: 2516 LLTSIPVSTTPVASPEASTLSTTPVDSNSPVV----------TSTEISSSATSAEGTSMP 2565
Query: 712 VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDS 771
L+ S S T P T VT E S S D+
Sbjct: 2566 TSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTT----STETSSSPTTAKDT 2621
Query: 772 EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVK--- 828
++P++V TS+ P A+ S T + + + SP+ +
Sbjct: 2622 SMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSS 2681
Query: 829 PPVRNP-----------QNSTVLARGPASVPS-----VGKAVATAAQAQTGPEEDSGSSE 872
P P ++T+LA AS S V T+A+A + P G+S
Sbjct: 2682 MPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSM 2741
Query: 873 EESDSEEEAETLAQV 887
S + + L +
Sbjct: 2742 RISTPSDGSTPLTSI 2756
Score = 74.3 bits (181), Expect = 5e-13
Identities = 170/869 (19%), Positives = 293/869 (33%), Gaps = 99/869 (11%)
Query: 81 PISTSESSEEEEEAEAETAKATPR---LASTNSSVLGADLPSSMKEKAKAETEKAGKTGN 137
P ST ++S + +TP ++ST + V A LPS +A T K
Sbjct: 130 PSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSF-----EAYTSLTYKVDM 184
Query: 138 SMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQAD 197
S P L + S +TT+ T EGS P A V++ +A
Sbjct: 185 STP----------LTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAI 234
Query: 198 SSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP---APGKVGDVTPQVKG 254
+ S + + S P + S+S +P+ + P P V V
Sbjct: 235 TLLTTPVEISTPVTISAQASSSPTTAEGPSLS-NSAPSGGSTPLTRMPLSVMLVVSSEAS 293
Query: 255 GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
P S + + E T + + S + A++ P +
Sbjct: 294 TLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMST 353
Query: 315 ATPAPPGKAGAVASQTKAGKPEEDSESSS------EESSDSEEETPAAKALLQAKASGKT 368
+ P + V + T+ +E++S E S P + L+ + + T
Sbjct: 354 LSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTT 413
Query: 369 SQV------------GAASAP--------AKESPRKGAAP--APPGKTGPAVAKAQAGKR 406
S + A+S+P A +P +G+ P + P T P +
Sbjct: 414 STIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVAS------- 466
Query: 407 EEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQV 466
E S S+ DS+ + + S P S P +P +G+ P T + + +
Sbjct: 467 SEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPT-STPSEGSTPL----TSMSVSTM 521
Query: 467 QVGKQEEDSRSSSE-ESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
V E + S++ ++ + + +++ P G S P ST G PV
Sbjct: 522 PVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTS---IPTSTPSEGSTPLTNMPVS 578
Query: 526 PGKV--GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583
V A+ ++ ++S E+S SS T++ + G + + S+
Sbjct: 579 TRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVST 638
Query: 584 PAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP--QT 641
+ + V + P+ S + SS +A+ P + + P +P T
Sbjct: 639 TLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTT 698
Query: 642 KACPKKTNTTASAKV---APVRVGTQAPRKAGTA--------TSPAGSSPAVAGGTQRPA 690
+ +T ++ V PV T+A TA T GS+P + +
Sbjct: 699 LVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTL 758
Query: 691 EDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT 750
SS + + T +T S + S+P+ S +P+L T
Sbjct: 759 LTSSEASTLSTTPLDTSTHITTSTEASCSP-TTTEGTSMPI--STPSEGSPLL---TSIP 812
Query: 751 VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPG 810
V+ E S S DS + +V +S + + P + + S P
Sbjct: 813 VSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPV 872
Query: 811 K---VVTAAAQAKQRSPSKVKPPVRN---PQNSTVLARG---PASVPSVGKAVATAAQAQ 861
V T+A +P PV N ++S + G P S P G T+
Sbjct: 873 STTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDS 932
Query: 862 TGPEEDSGSSEEESDSEEEAETLAQVKPS 890
T P SSE + S +T V S
Sbjct: 933 TTPVV---SSEARTLSATPVDTSTPVTTS 958
Score = 73.9 bits (180), Expect = 7e-13
Identities = 157/855 (18%), Positives = 288/855 (33%), Gaps = 95/855 (11%)
Query: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
ST ++ E + TA+AT L ST S G+ ++M T +++P
Sbjct: 362 STLVTTSTEPSSLPTTAEATSMLTSTLSE--GSTPLTNMPVSTILVASSEASTTSTIP-- 417
Query: 143 ATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQAD----- 197
KT S S S + +T++ + T EGS P V++ +A
Sbjct: 418 VDSKTFVTTASEAS--SSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNLSTT 475
Query: 198 --------SSSEDTSSSSDETDVEGKPSVKPAQ----VKASSVSTKESPARKAAPAPGKV 245
++S + SSS +V P+ P++ + + SVST + +A+
Sbjct: 476 PVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTP 535
Query: 246 GDVTPQVKGGALPPAKRAKKPEEES---ESSEEGSESEEEAPAGTR----------SQVK 292
D + V + + + PE S + EGS P TR S
Sbjct: 536 VDTSTPVTTSS-EASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTP 594
Query: 293 ASEKILQVRAASAPAKGTPGKGA---TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 349
A ++ A + T +G T + + S + + SE+S+ ++
Sbjct: 595 ADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPV 654
Query: 350 EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409
+ TP + +A+ ++ S P + +G+ P + + E
Sbjct: 655 DSNTPVTTS---TEATSSSTTAEGTSMPT-STYTEGSTPLTSMPVNTTLVAS-----SEA 705
Query: 410 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP---APPRKTGPAAAQV 466
S S+ D+ + S AS P +P +G+ P P KT +++
Sbjct: 706 STLSTTPVDTSTPVTTSTEASSSPTTADGASMPT-STPSEGSTPLTSMPVSKTLLTSSEA 764
Query: 467 QVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKP-------ASTMGMGPLGK 519
S+ + ++ P+ + P + T P
Sbjct: 765 STLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEAS 824
Query: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579
P P T S +V +E +S +S S+G P P + +
Sbjct: 825 TLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAIST 884
Query: 580 PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIP 639
+++P V P+ NS + S +++ P + + P +P
Sbjct: 885 LSTTP--------------VDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMP 930
Query: 640 QTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEES 699
+ P ++ + PV T T ++ A SSP A GT P S
Sbjct: 931 DS-TTPVVSSEARTLSATPVDTSTPV-----TTSTEATSSPTTAEGTSIPTSTPSEGTTP 984
Query: 700 DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE-- 757
+ + V +A ++ V + + + P G + PT T +
Sbjct: 985 LTSTPVSHTLVANSEASTLST-TPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTP 1043
Query: 758 --KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTA 815
+ S + S++ + +PA T V + A++ + +A GT S P +
Sbjct: 1044 LTRMPVSTTMVASSETSTLSTTPADTSTPV----TTYSQASSSSTTADGT-SMPTSTYSE 1098
Query: 816 AAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEES 875
+ P + V + ++ S+P V T+ +A + P G+S S
Sbjct: 1099 GSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIP-----VTTSTEASSSPTTAEGTSIPTS 1153
Query: 876 DSEEEAETLAQVKPS 890
E LA + S
Sbjct: 1154 PPSEGTTPLASMPVS 1168
Score = 72.8 bits (177), Expect = 1e-12
Identities = 170/930 (18%), Positives = 305/930 (32%), Gaps = 113/930 (12%)
Query: 83 STSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHP 142
S S+ + +EA T TP ST ++ A SS + +G S P
Sbjct: 220 SMPASTMKVASSEAITLLTTPVEISTPVTI-SAQASSSPTTAEGPSLSNSAPSGGSTPLT 278
Query: 143 ATGKTVANLLSGKSPRKSAEPSAN-------------------TTLVSETEEEGSVPAFG 183
+V ++S ++ S P+A T++ + T EGS P
Sbjct: 279 RMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTS 338
Query: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPG 243
A V+ + + S +S +PS P +A+S+ T
Sbjct: 339 TPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNM 398
Query: 244 KVGDV---TPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300
V + + + + P SE+S + +E+ + A T + + S + +
Sbjct: 399 PVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIA-TSTPSEGSTPLTSM 457
Query: 301 RAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE-SSSEESSDSEEETP----- 354
++ P + + P V + T+A +E +S S+ SE TP
Sbjct: 458 PVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMS 517
Query: 355 -AAKALLQAKASG-KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGK------- 405
+ + ++AS T+ V ++ S ++ P G + P ++
Sbjct: 518 VSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNMPV 577
Query: 406 ------REEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT 459
E S +S+ +DS ++ S + S P +G +
Sbjct: 578 STRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVS 637
Query: 460 GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPL-- 517
A + S+ + EA ++ A+ + S + ++ + P+
Sbjct: 638 TTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNT 697
Query: 518 -------GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK 570
P P T S + ++ +S +S S+G P P +
Sbjct: 698 TLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKT 757
Query: 571 SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAA 630
L TSS A + P+D S S++++ S +
Sbjct: 758 LL--------TSSEA------------STLSTTPLDTSTHITTSTEASCSPTTTEGTSMP 797
Query: 631 QAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
+ P+ P + P S + + + T ++ SSP A GT P
Sbjct: 798 ISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMP- 856
Query: 691 EDSSSSEESDSEEEKTGLAV-TVGQAKSVGKGLQVKA--ASVPVKGSLGQGTAPVL-PGK 746
+S S+ T + V T A S L S PV S ++P G
Sbjct: 857 ----TSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGT 912
Query: 747 TGPTVT----QVKAEKQEDSESSEEESDSEEAAASPAQVKTSV-KKTQAKANPAAARAPS 801
+ PT T DS + S++ +A+P T V T+A ++P A S
Sbjct: 913 SMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTS 972
Query: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV-----GKAVAT 856
+ + G P P + T++A AS S + T
Sbjct: 973 IPTSTPSEG----------------TTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTT 1016
Query: 857 AAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPP 916
+ +A + P G+S S E + L ++ P T + + +P A + P
Sbjct: 1017 STEASSPPPTAEGTSMPTSTPSEGSTPLTRM-PVSTTMVASSETSTLSTTP---ADTSTP 1072
Query: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAP 946
T A+ + D S + S+G P
Sbjct: 1073 VTTYSQASSSSTTADGTSMPTSTYSEGSTP 1102
Score = 61.6 bits (148), Expect = 3e-09
Identities = 184/966 (19%), Positives = 312/966 (32%), Gaps = 159/966 (16%)
Query: 65 AEEDAALQAKKTRVSDPISTSESSEEEEEAEAET-AKATPR---------------LAST 108
+ ED+ L A S P++TS + AE + +TP +AS+
Sbjct: 3178 SSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASS 3237
Query: 109 NSSVLG---ADLPSSMKEKAKAETEKAGKTGNSMP-------------HPATGKTVANL- 151
+S+L D + + +A + G SMP P + TVA+
Sbjct: 3238 EASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSE 3297
Query: 152 --------------LSGKSPRKSAEPSAN-TTLVSETEEEGSVPAFGAAAKPGMVSAGQA 196
++ S S+ P A+ T++ + T EGS P + V + +A
Sbjct: 3298 TSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEA 3357
Query: 197 DSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
+ S +S + S+ P + +S+ T SP+ P TP V
Sbjct: 3358 STLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPT-SSPSEGTTPLASMPVSTTPVVSSEV 3416
Query: 257 LPPAKRAKKPEEESESSEEGSESEEEA-----PAGTRSQVKASEKILQVRAASAPAKGTP 311
+ +S E S S A P T S+ I+ + +
Sbjct: 3417 NTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEAS 3476
Query: 312 GKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP------AAKALLQAKAS 365
TP +S T + P +S S+ E TP + + ++AS
Sbjct: 3477 TLSTTPVDTSTPVTTSSPTNS-SPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEAS 3535
Query: 366 GKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPA 425
++ ++ S + ++PA T ++ G + S + EA
Sbjct: 3536 TLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEAST 3595
Query: 426 QAKPSGKAPQVRAASAPAKESPRKGAAPAPPR-----KTGPAAAQVQVGKQEEDSRSSSE 480
+ PS S P S + + P PP + P+ + + S +
Sbjct: 3596 PSTPSVD------RSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTI 3649
Query: 481 ESDSDREALAAMNAAQV---KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGP------ 531
L + V + SP +TM + +G+ P+ V
Sbjct: 3650 SEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSS 3709
Query: 532 -----ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586
+TPS V + + + SS + D + P + +LG + T P
Sbjct: 3710 EGSTLSTPSV-VTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTT--PVT 3766
Query: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSD----------SADSEEAP----------AA 626
P+ + P V M + S S SE + +
Sbjct: 3767 RFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISV 3826
Query: 627 MTAAQAKPALKIPQTKACPKKTNTTAS-----AKVAPVRVGTQAPRKAGTAT-------- 673
M+ ++A P + P T+T A A+V +R+ + R T
Sbjct: 3827 MSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLP 3886
Query: 674 ------SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAA 727
S A + P T P+ D++S+ + +T G G +
Sbjct: 3887 TSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGST----PGTTIFIP 3942
Query: 728 SVPVKGSLGQGTAPVLPGKTG----PTVTQVKAEKQEDSESSEEESDSEE--------AA 775
S PV S TA V P TG P +T + S SS S S
Sbjct: 3943 STPVTSS----TADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTT 3998
Query: 776 ASPAQVKT-----SVKKTQAKANPAAARAPSAKGT----ISAPGKVVTAAAQAKQRS--P 824
A+P T S +T ++ +A SA T S + VT ++++ + S
Sbjct: 3999 AAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTIT 4058
Query: 825 SKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETL 884
S PP P +S+ AS +V T +T P + S + + T
Sbjct: 4059 SHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTT 4118
Query: 885 AQVKPS 890
+ P+
Sbjct: 4119 IKSNPT 4124
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 87.0 bits (214), Expect = 7e-17
Identities = 195/867 (22%), Positives = 313/867 (36%), Gaps = 115/867 (13%)
Query: 57 SELGRKRKAEEDAALQAK--KTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
S+ GR R D ALQ+ T + + ++ +EE A T R S
Sbjct: 1482 SKPGRTRG---DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
Query: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
+ P KE K + P PA +T +L++ ++P + S+ ++L +E
Sbjct: 1539 RERPQGRKE-----APAPSKAAPAAPPPA--RTQPSLIADETPPCYSLSSSASSL---SE 1588
Query: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
E S P P + G+ + ++D + PS + A+ + P
Sbjct: 1589 PEPSEP-------PAVHPRGREPAVTKDPGPGGGR---DSSPSPRAAEELLQRCISSALP 1638
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE------------- 281
R+ P + P+ PA+ +++ EE+ S+ S+ +
Sbjct: 1639 RRR--PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI 1696
Query: 282 -----EAPAGTRSQVKASEKILQ------VRAASAPAKGTPGKGA-----TPAPPGKAGA 325
+A A TR S+ IL V + P K G+ A + P K GA
Sbjct: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA 1756
Query: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
+ +T +G P S + E+ +++ TP A+L+ + + P K +P
Sbjct: 1757 ASVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPR 1812
Query: 386 AAP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
A P APP PA ++ S+S + + E A P P R A P
Sbjct: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
Query: 443 AKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
+ S + A P PRK P Q +S R LA + Q P+
Sbjct: 1873 SSSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV- 1928
Query: 502 KSPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDS 555
+ P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD
Sbjct: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
Query: 556 SDGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
S +P + + A+ +S +G + G A+ P SS
Sbjct: 1989 SGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSR 2042
Query: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA--- 669
A + PA A+ +P P P + T+ S PVR P
Sbjct: 2043 CEELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
Query: 670 ------GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKS 717
A P G+ PA PA ++ SD E G + +
Sbjct: 2100 ASLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDED 2153
Query: 718 VGKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEE 773
V L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 2154 VPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETRE 2213
Query: 774 AAASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PP 830
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 2214 PPGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPP 2272
Query: 831 VRNPQNSTVLARGPASVPSVGKAVATA 857
+ V+A S A A+A
Sbjct: 2273 FNYVPSPMVVAATTDSAAEKAPATASA 2299
Score = 66.6 bits (161), Expect = 1e-10
Identities = 188/847 (22%), Positives = 292/847 (34%), Gaps = 128/847 (15%)
Query: 171 SETEEEGSVPAFGAAAKPGMVSA-----GQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
SE E + + A GA + P + A G+ + T SSS E V+ P V
Sbjct: 1106 SEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSV 1165
Query: 226 SSVSTKESPARKAA----PAPGK-VGDVT----PQVKGGALPPAKR-----AKKPEEESE 271
SS+ + ESP+ ++ P G+ G ++ P G +PP++ A P+ E
Sbjct: 1166 SSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPE 1225
Query: 272 SSEEGSE---------------------SEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
+++ + SE +A + + K E + SA A
Sbjct: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
Query: 311 PG----------KGATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKA 358
A P G AG + E+ + + S +++E +
Sbjct: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
Query: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS-------- 410
L A + +V +A P + A P P PA A AQ DS
Sbjct: 1346 CLGAAVPARLRKVASALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNF 1400
Query: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
S++ SD + P + +P G A + R P G K G A G+
Sbjct: 1401 SSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GR 1450
Query: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP-LGKGAGPVPPGKV 529
E SR + + A PLG+ P PA G P +G G + +
Sbjct: 1451 SAEQSRGAGKN-----------RAGLELPLGRPPSA-PADKDGSKPGRTRGDGALQSLCL 1498
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA--QEKSLGNILQAKPT-SSPAK 586
T A + DS+ ++ + +A+ A +E+ G P+ ++PA
Sbjct: 1499 TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAA 1558
Query: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL-KIPQTKACP 645
PP + P + E P S SS SS S P A+ +PA+ K P
Sbjct: 1559 PPPARTQPSL--IADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGR 1616
Query: 646 KKTNTTASAKVAPVR-VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEE 703
+ + +A+ R + + PR+ + P +RPAE S EE+ +
Sbjct: 1617 DSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSD 1676
Query: 704 EKTGL------AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG-KTGPTVTQVKA 756
+ L A+ G A S+ L AA+ S + G G T+ K
Sbjct: 1677 RASDLDSVEWRAIQEG-ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKH 1735
Query: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
K +E + E + SVK + + +PA P +GT + T
Sbjct: 1736 RKGRQAEGEMGSARRPEKRGA-----ASVKTSGSPRSPAGPEKP--RGT-----QKTTPG 1783
Query: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ-------TGPEEDSG 869
A R + + P P+ GP + P + VA AQ P +
Sbjct: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRS 1840
Query: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGK 928
S E TL+Q P T R A P+ S + A P P K P AG
Sbjct: 1841 RSLHRPAKTSELATLSQ-PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA 1899
Query: 929 QDDSGSS 935
G+S
Sbjct: 1900 LPGPGAS 1906
Score = 60.5 bits (145), Expect = 7e-09
Identities = 192/944 (20%), Positives = 312/944 (33%), Gaps = 176/944 (18%)
Query: 85 SESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPAT 144
+E E A A AKA LA L D+ + + + +G G P
Sbjct: 829 AEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGR 888
Query: 145 GKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTS 204
++ + + R+ A A+ L + A A S++ +
Sbjct: 889 AQSCSPCRGPEGGRREAGSRAHPLL--------------------RLKAAHASLSNDSLN 928
Query: 205 SSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG-DVTPQVKGGALPPAKRA 263
S S + + P + A+ S +E P R P P ++ D+ P +A
Sbjct: 929 SGSASDGYCPREHMLPCPL-AALASRREDP-RCGQPRPSRLDLDL----------PGCQA 976
Query: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
+ P E+ S++ + + +P T V E A+ A A+ G G +P +A
Sbjct: 977 EPPAREATSADARVRTIKLSP--TYQHVPLLEG-----ASRAGAEPLAGPGISPGARKQA 1029
Query: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383
A PE+ + + +S + ++ A + L S + +A
Sbjct: 1030 WLPADHLSK-VPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSA--------- 1079
Query: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
G+ GP+ G +DS SS E + + A+ + +AP A S P
Sbjct: 1080 --------GRPGPS-----EGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPG--ATSLPV 1124
Query: 444 KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG-- 501
A PAP R G E+ + SSS E+ L + V LG
Sbjct: 1125 -------AIPAPRRNRGRGLGV------EDATPSSSSENYVQETPLVLSRCSSVSSLGSF 1171
Query: 502 KSPQV------KPASTMGMGPLGKGAGPVPPG--------KVGPATPSAQVG-------- 539
+SP + +P S G G + P PG K P P+ Q
Sbjct: 1172 ESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSL 1231
Query: 540 KWEE---------DSESSSEESSDSSDGEVPTAVAPAQEK-----SLGNI---------- 575
+WE D S+ G V V E SL +
Sbjct: 1232 QWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQD 1291
Query: 576 --LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE------------ 621
L+ P++ P +G + + + + +AD E
Sbjct: 1292 VELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAV 1351
Query: 622 ------EAPAAMTAAQAKPA---LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
A A + +A P + +P + + T SA+ PV + A T
Sbjct: 1352 PARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETL 1411
Query: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLA-VTVGQAKSVGK---GLQVKAAS 728
P P G QRP +S+ ++ K G A + Q++ GK GL++
Sbjct: 1412 QGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGR 1471
Query: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
P + G+ P G + E++ +DS+E + A T ++T
Sbjct: 1472 PPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH-RRT 1530
Query: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKV---KPPVRNPQN--STVLARG 843
A P + AP K AA + PS + PP + + S++
Sbjct: 1531 SAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPE 1590
Query: 844 PASVPSV-GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
P+ P+V + A GP G + S S AE L Q I +AL P
Sbjct: 1591 PSEPPAVHPRGREPAVTKDPGP----GGGRDSSPSPRAAEELLQ-------RCISSAL-P 1638
Query: 903 AKESPRKGAAPTPPGKT----GPSAAQAGKQDDSGSSSEESDSD 942
+ P G P T P+ + +++ S SD D
Sbjct: 1639 RRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLD 1682
Score = 53.1 bits (126), Expect = 1e-06
Identities = 156/749 (20%), Positives = 263/749 (35%), Gaps = 143/749 (19%)
Query: 258 PPAKRA--KKPEE---------ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAP 306
PPA A KKP + +S+ G +++AP+ A+A
Sbjct: 747 PPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSL---------------AAAA 791
Query: 307 AKGTPGKGA-------TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359
A G P A +P G+A A T+ G E + ++S E + ++ + A A+
Sbjct: 792 ATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAV 851
Query: 360 LQAK----------ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE- 408
+ S S ++ P +E+PR+G A + GP + +AG R
Sbjct: 852 ARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHP 911
Query: 409 -------DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGP 461
+ S++ +S + P AA A +E PR G P P R
Sbjct: 912 LLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG-QPRPSRLDLD 970
Query: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGA 521
G Q E + +D+ + Q PL ++ AS G PL G
Sbjct: 971 LP-----GCQAEPPAREATSADARVRTIKLSPTYQHVPL-----LEGASRAGAEPLA-GP 1019
Query: 522 GPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581
G P + P+ + K E ++ + + ++ P SL
Sbjct: 1020 GISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPL---SLSRCSSLSSL 1076
Query: 582 SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT 641
SS + P + G +D+S+SS E + A EA ++ T
Sbjct: 1077 SSAGRPGPSEGG----------DLDDSDSSLEGLEEAGPSEA-------------ELDST 1113
Query: 642 KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDS 701
P T+ + V APR+ G ED++ S S++
Sbjct: 1114 WRAPGATS---------LPVAIPAPRR--------------NRGRGLGVEDATPSSSSEN 1150
Query: 702 EEEKTGLAVT-VGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTGPTVTQ-VKAEK 758
++T L ++ S+G A+S+P + GQG+ + P + + Q + +
Sbjct: 1151 YVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSR 1210
Query: 759 QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGK 811
+ + EA Q ++ VK+ A+ P+ A S + T+ P +
Sbjct: 1211 SKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDE 1270
Query: 812 VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA-------QAQTGP 864
+ A+ S S + Q L P++ P G A + + GP
Sbjct: 1271 NFSCAS-----SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGP 1325
Query: 865 EEDSGSSEEESDSEEE--AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS 922
+D E E E L P+ + ++ +AL P + A P P P+
Sbjct: 1326 APTGSRPRGAADQELELLRECLGAAVPA-RLRKVASALVPGRR-----ALPVPVYMLVPA 1379
Query: 923 AAQAGKQDDSGSSSEESDSDGEAPAAVTS 951
A A ++DDS + S E + AA S
Sbjct: 1380 PAPA-QEDDSCTDSAEGTPVNFSSAASLS 1407
>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
Length = 1427
Score = 85.9 bits (211), Expect = 2e-16
Identities = 139/590 (23%), Positives = 215/590 (36%), Gaps = 70/590 (11%)
Query: 56 TSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA 115
+SE G + + D+ L + +E EE + T + + + L A
Sbjct: 791 SSEGGEMERRDSDSFLNIFPEKQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDA-LDA 849
Query: 116 DLPSSMKEKAKAET---EKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSE 172
LPS + + A E +P P VA+++S E T
Sbjct: 850 ALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVS-------LEEEDVTAAAVS 902
Query: 173 TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232
E +VPA + G + S E + + EG +V + +++
Sbjct: 903 APERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAAL---- 958
Query: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVK 292
A P D TP+ G + PA PEE ++ S EE PA + V
Sbjct: 959 -----AITVPITEEDGTPE---GPVTPATTVHAPEEPDTAAVRVSTPEE--PASPAAAVP 1008
Query: 293 ASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEE 352
E+ AA+ P P A PP PEE + ++ + E
Sbjct: 1009 TPEEPTSP-AAAVPTPEEPTSPAAAVPP--------------PEEPTSPAAAVPTPEEPT 1053
Query: 353 TPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS 412
+PAA A + + AA+ P E P AA P + + A A E S +
Sbjct: 1054 SPAA-----AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPA 1108
Query: 413 SSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
++ + E +PA A P+ + P AA+ P E P APA P A+A V V E
Sbjct: 1109 AAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEP-AFPAPAVPTPEESASAAVAVPTPE 1167
Query: 473 ED-SRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP--PGKV 529
E S +++ + ++ + AA+ A +P + V + M + L + P P
Sbjct: 1168 ESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAM-VATLEEFTSPAASVPTSE 1226
Query: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG-- 587
PA+ +A V S+ E S VPT P S +L + SSPA
Sbjct: 1227 EPASLAAAV---------SNPEEPTSPAAAVPTLEEPT--SSAAAVLTPEELSSPAASVP 1275
Query: 588 -PPQKAGPVAVQVKAEKP------MDNSESSEESSDSADSEEAPAAMTAA 630
P + A P A E+P + E + + S + E PA AA
Sbjct: 1276 TPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAA 1325
Score = 71.6 bits (174), Expect = 3e-12
Identities = 138/594 (23%), Positives = 203/594 (34%), Gaps = 82/594 (13%)
Query: 335 PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA-PAPPGK 393
PE+ + EE P L + + V A A SP +G + A P
Sbjct: 810 PEKQVTKAGNTEPVLEEWIPV---LQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAP 866
Query: 394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP 453
G AV A ED +S S EE+ A A + + V A + E AA
Sbjct: 867 EGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAV 926
Query: 454 APPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG 513
+ P +T PA A ++ S+ + ALA + V PA+T+
Sbjct: 927 SSPEETAPAVAAAIT----QEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPATTVH 982
Query: 514 MGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLG 573
A PA+P+A V EE + ++ + AV P +E
Sbjct: 983 APEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEE---- 1038
Query: 574 NILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAK 633
PTS PA P P + P E + + + E P + AA
Sbjct: 1039 ------PTS-PAAAVPTPEEPTSPAAAVPTP----EEPTSPAAAVPTPEEPTSPAAAVPT 1087
Query: 634 PALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS 693
P A P T+ A P +P A T +SPA A T P E +
Sbjct: 1088 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPA-AAVPTPEEPASPAAAVPT--PEEPA 1144
Query: 694 SSSEESDSEEEKTGLAVTVG---QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT 750
+ + EE AV V ++ S + A S + P P + PT
Sbjct: 1145 FPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPT 1204
Query: 751 VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPG 810
+ A +E + + SEE PA + +V + +PAAA P+ + S+
Sbjct: 1205 PAAMVATLEEFTSPAASVPTSEE----PASLAAAVSNPEEPTSPAAA-VPTLEEPTSSAA 1259
Query: 811 KVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGS 870
V+T P ++ P ASVP+ PEE +
Sbjct: 1260 AVLT---------PEELSSPA-------------ASVPT--------------PEEPASP 1283
Query: 871 SEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
+ S+ EE A A V P+ + I AA + PTP P+AA
Sbjct: 1284 AAAVSNLEEPASPAAAV-PTPEVAAIPAA-----------SVPTPEVPAIPAAA 1325
Score = 69.3 bits (168), Expect = 2e-11
Identities = 142/578 (24%), Positives = 198/578 (34%), Gaps = 104/578 (17%)
Query: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361
A +P +GT A PAP G A A P ED +S S + E+ T AA +
Sbjct: 850 ALPSPEEGT-SIAAVPAPEGTAVVAAL---VPFPHEDILVASIVSLEEEDVTAAAVS--- 902
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKA--QAGKREEDSQSSS----- 414
+ + + V A + E AA + P +T PAVA A Q G S
Sbjct: 903 ---APERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAALA 959
Query: 415 -----EESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA-----PPRKTGPAAA 464
E D E P + AP+ +A +P + A+PA P T PAAA
Sbjct: 960 ITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAA 1019
Query: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 524
V EE + ++ + + A P + P PA+ +
Sbjct: 1020 ---VPTPEEPTSPAAAVPPPEEPT----SPAAAVPTPEEP-TSPAAAVPTPEEPTSPAAA 1071
Query: 525 PPGKVGPATPSAQVGKWEEDSESSSE----ESSDSSDGEVPTAVAPAQEKSLGNILQAKP 580
P P +P+A V EE + ++ E S VPT PA + A P
Sbjct: 1072 VPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAA------AVP 1125
Query: 581 TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ 640
T P + A P A E+P + + P +A A A+ P+
Sbjct: 1126 T------PEEPASPAAAVPTPEEP------------AFPAPAVPTPEESASAAVAVPTPE 1167
Query: 641 TKACPKKTNTTA--SAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
A P T SA A V + P TSPA S P A E +S +
Sbjct: 1168 ESASPAAAVPTPAESASFAAVVATLEEP------TSPAASVPTPAAMVATLEEFTSPAAS 1221
Query: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEK 758
+ EE LA V + AA+VP A VL
Sbjct: 1222 VPTSEEPASLAAAVSNPEEPTS----PAAAVPTLEEPTSSAAAVLT-------------- 1263
Query: 759 QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQ 818
E+ S + E ASPA +V + A+PAAA P+ + V T
Sbjct: 1264 PEELSSPAASVPTPEEPASPA---AAVSNLEEPASPAAA-VPTPEVAAIPAASVPTPEVP 1319
Query: 819 AKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVAT 856
A P+ PP+ P VP +G + T
Sbjct: 1320 A---IPAAAVPPMEEV--------SPIGVPFLGVSAHT 1346
Score = 65.1 bits (157), Expect = 3e-10
Identities = 109/428 (25%), Positives = 159/428 (37%), Gaps = 51/428 (11%)
Query: 66 EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125
EED + T P +T + EE + A + TP ++ ++ + + A
Sbjct: 966 EEDGTPEGPVT----PATTVHAPEEPDTAAVRVS--TPEEPASPAAAVPTPEEPTSPAAA 1019
Query: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
E+ ++P P + A + +P + P+A T EE + PA
Sbjct: 1020 VPTPEEPTSPAAAVPPPEEPTSPAAAVP--TPEEPTSPAAAVP----TPEEPTSPAAAVP 1073
Query: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
S A + E+ +S + +P+ A++V T E PA AA P
Sbjct: 1074 TPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSP-----AAAVPTPEEPASPAAAVP--- 1125
Query: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
TP+ PA PEE + + EE A A V E+ A+ A
Sbjct: 1126 ---TPEEPAS---PAAAVPTPEEPAFPAPAVPTPEESASAAVA--VPTPEE----SASPA 1173
Query: 306 PAKGTPGKGATPA--------PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAK 357
A TP + A+ A P A +V T A E +S +S E PA+
Sbjct: 1174 AAVPTPAESASFAAVVATLEEPTSPAASVP--TPAAMVATLEEFTSPAASVPTSEEPASL 1231
Query: 358 ALLQAKASGKTSQVGAASAPAKESPRKGAAPA--PPGKTGPAVAKAQAGKREEDSQSSSE 415
A + TS AA+ P E P AA P + PA A EE + ++
Sbjct: 1232 AAAVSNPEEPTSP--AAAVPTLEEPTSSAAAVLTPEELSSPA---ASVPTPEEPASPAAA 1286
Query: 416 ESDSEEEA-PAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP-RKTGPAAAQVQVGKQEE 473
S+ EE A PA A P+ + + AAS P E P AA PP + P
Sbjct: 1287 VSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHT 1346
Query: 474 DSRSSSEE 481
DS SEE
Sbjct: 1347 DSVPISEE 1354
Score = 57.0 bits (136), Expect = 8e-08
Identities = 135/557 (24%), Positives = 193/557 (34%), Gaps = 99/557 (17%)
Query: 410 SQSSSEESDSEEEAPAQAKPSGKA--PQVRAASAPAKESPRKGAA-PAPPRKTGPAAAQV 466
+++ + E EE P +PS A P V+ A A SP +G + A P G A
Sbjct: 815 TKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAA 874
Query: 467 QVGKQEED----SRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522
V ED S S EE D A++A A V PA T+ + P G A
Sbjct: 875 LVPFPHEDILVASIVSLEEEDVTAAAVSAPERATV----------PAVTVSV-PEGTAAV 923
Query: 523 PV--PPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKP 580
P + PA +A E S + S + P E+
Sbjct: 924 AAVSSPEETAPAVAAAIT------QEGMSAVAGFSPEWAALAITVPITEED--------- 968
Query: 581 TSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ 640
G P+ GPV P E + ++ + E PA+ AA P
Sbjct: 969 ------GTPE--GPVTPATTVHAP----EEPDTAAVRVSTPEEPASPAAAVPTPEEPTSP 1016
Query: 641 TKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD 700
A P T+ A P +P A T +SPA A T P E +S +
Sbjct: 1017 AAAVPTPEEPTSPAAAVPPPEEPTSPA-AAVPTPEEPTSPAAAVPT--PEEPTSPAAAVP 1073
Query: 701 SEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE 760
+ EE T AA+VP P P PT E
Sbjct: 1074 TPEEPTS-----------------PAAAVPTPEE------PTSPAAAVPT--------PE 1102
Query: 761 DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAK 820
+ S + E ASPA +V + A+PAAA + AP A +
Sbjct: 1103 EPTSPAAAVPTPEEPASPA---AAVPTPEEPASPAAAVPTPEEPAFPAP-----AVPTPE 1154
Query: 821 QRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSE-- 878
+ + + V P P+ S A A+VP+ ++ + AA T E S ++ + +
Sbjct: 1155 ESASAAVAVPT--PEES---ASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMV 1209
Query: 879 ---EEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSS 935
EE + A P+ + AA E P AA P + S+A A + SS
Sbjct: 1210 ATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSS 1269
Query: 936 SEESDSDGEAPAAVTSA 952
S E PA+ +A
Sbjct: 1270 PAASVPTPEEPASPAAA 1286
Score = 53.9 bits (128), Expect = 7e-07
Identities = 79/318 (24%), Positives = 126/318 (39%), Gaps = 30/318 (9%)
Query: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
++ + TA+A AP R A A T + P G++ A P E + + + ++E
Sbjct: 892 EEEDVTAAAVSAPER----ATVPAVTVSVPEGTAAVAA--VSSPEETAPAVAAAITQE-- 943
Query: 706 TGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
G++ G + A +VP+ G PV P T V A ++ D+ ++
Sbjct: 944 -GMSAVAGFSPEWA----ALAITVPITEEDGTPEGPVTPATT------VHAPEEPDT-AA 991
Query: 766 EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT--AAAQAKQRS 823
S EE A+ A V T + T A P++ P + T AAA
Sbjct: 992 VRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEE 1051
Query: 824 PSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAET 883
P+ V P+ T A A+VP+ + + AA T PEE + + EE
Sbjct: 1052 PTSPAAAVPTPEEPTSPA---AAVPTPEEPTSPAAAVPT-PEEPTSPAAAVPTPEEPTSP 1107
Query: 884 LAQVKPSGKTHQIRAALAPAKESPRKGAA--PTPPGKTGPS-AAQAGKQDDSGSSSEESD 940
A V P+ + AA P E P AA PTP P+ A ++ S + + +
Sbjct: 1108 AAAV-PTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTP 1166
Query: 941 SDGEAPAAVTSAQDQESS 958
+ +PAA + +S
Sbjct: 1167 EESASPAAAVPTPAESAS 1184
>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 1487
Score = 84.7 bits (208), Expect = 4e-16
Identities = 181/821 (22%), Positives = 254/821 (30%), Gaps = 125/821 (15%)
Query: 214 GKPSVKPAQVKASSVSTKESPARKAAPA-PGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
GKP K + P + A PG G P VKG P K E +
Sbjct: 249 GKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPG--LPGVKGHRGYPGLDGAKGEAGAPG 306
Query: 273 --SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
E GS E +P + E+ A +A A+G G+ PPG G
Sbjct: 307 VKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPG 366
Query: 331 KAGKPEEDSES--------SSEESSDSEEETPAAKALLQAK----------ASGKTSQVG 372
G P E+ + E TP + A A G G
Sbjct: 367 FPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPG 426
Query: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
A AP PR P P G TGP K Q G E + + + P A P G
Sbjct: 427 IAGAPGFPGPR--GPPGPQGATGPLGPKGQTG---EPGIAGFKGEQGPKGEPGPAGPQG- 480
Query: 433 APQVRAASAPAKESPRKGA-----APAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR- 486
A PA E ++GA P G A G +D + + + +R
Sbjct: 481 ------APGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERG 534
Query: 487 -EALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
LA A P G+ + P G G+ P GKVGP+ + G+
Sbjct: 535 PSGLAGPKGANGDP-GRPGE--PGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPG 591
Query: 546 ESSSEESSDSSDGEVPTAV----APAQEKSLGNI-----LQAKPTSSPAKGPPQKAGPVA 596
+ P A EK L L K + A GPP AGP
Sbjct: 592 PQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAG 651
Query: 597 VQVKAEKPMDN------------SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
+ + P + E + E + + + P +
Sbjct: 652 ERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERG--FPGERGS 709
Query: 645 PKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS--PAVAG--------GTQRPAED-- 692
P + P GT P+ A P G+ P + G G P D
Sbjct: 710 P-GAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRG 768
Query: 693 ---SSSSEESDSEEEKTGLAVTVGQAKSVG-KGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
E + ++ GL +G G G + + GS G AP G+TG
Sbjct: 769 DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 828
Query: 749 PT-----VTQVKAEKQEDSESSEEESDSEEAAASPA----------QVKTSVKKTQ---- 789
P A+ Q ++ + E+ + A +P Q T V +
Sbjct: 829 PPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 888
Query: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
A+ P A P A G + PG +P PP + ++ ARG + P
Sbjct: 889 AQGPPGATGFPGAAGRVGPPG---------SNGNPGPPGPPGPSGKDGPKGARGDSGPP- 938
Query: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 909
G+A Q GP + G ++ S E P G Q P + R
Sbjct: 939 -GRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPP----GPQGLAGQRGIVGLPGQRGERG 993
Query: 910 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT 950
PG GPS + GKQ G+S + P +T
Sbjct: 994 F-----PGLPGPS-GEPGKQGAPGASGDRGPPGPVGPPGLT 1028
Score = 69.3 bits (168), Expect = 2e-11
Identities = 187/870 (21%), Positives = 248/870 (28%), Gaps = 141/870 (16%)
Query: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
+AG TG P A G G A + T + + GS A G A PG
Sbjct: 376 EAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAK--GSAGAPGIAGAPGF 433
Query: 191 VS--------------AGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+ + + E +G+P PA + + E R
Sbjct: 434 PGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPG--PAGPQGAPGPAGEEGKR 491
Query: 237 KAAPAPGKVGDVTPQVKGGALPPAKRA-----------KKPEEESESSEEGSESEEEAPA 285
A PG VG + P + GA P R P E S G + P
Sbjct: 492 GARGEPGGVGPIGPPGERGA--PGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPG 549
Query: 286 GTRSQVKASEKILQVRAASAPAKG------TPGKGATPAPPGKAGAVASQTKAGKPEEDS 339
+ L R A +G PG+ P PPG GA G P
Sbjct: 550 RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKG 609
Query: 340 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR----KGAAPAPPGKTG 395
++ E E+ P A L GK + GAA P P + AP P G G
Sbjct: 610 -ANGEPGKAGEKGLPGAPGL--RGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG 666
Query: 396 PAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKA--PQVRAA-SAPAKESPRKGAA 452
G E + + E AP P G+ P R + A + PR
Sbjct: 667 ---LPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPR--GL 721
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREA--LAAMNAAQVKPLGKSPQVKPAS 510
P P GP A G + +R A +A + K P+ P
Sbjct: 722 PGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGK 781
Query: 511 TMGMGPLGKGAGPVPPG------KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
G G G P P G +VGP P+ G + E G A
Sbjct: 782 DGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGA----RGAPGERGETGPPGPAGFAG 837
Query: 565 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624
P + G AKG +AG A P S P
Sbjct: 838 PPGADGQPG-----------AKGEQGEAGQKG---DAGAPGPQGPSGAPGPQGPTGVTGP 883
Query: 625 AAMTAAQAKP-ALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS-- 679
AQ P A P + P +N P G P+ A + P G +
Sbjct: 884 KGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGE 943
Query: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739
P + G P E ++ S E +GL + V + G G+
Sbjct: 944 PGLQGPAGPPGEKGEPGDDGPSGAE----------GPPGPQGLAGQRGIVGLPGQRGERG 993
Query: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
P LPG +G Q P A+
Sbjct: 994 FPGLPGPSGEPGKQ--------------------------------------GAPGASGD 1015
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
G + PG A ++ SP PP R+ RG +VG A
Sbjct: 1016 RGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETG--AVGAPGAPGPP 1073
Query: 860 AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919
GP +G + EA + PSG R P KG A PG+
Sbjct: 1074 GSPGPAGPTGKQGDRG----EAGAQGPMGPSGPA-GARGIQGPQGPRGDKGEA-GEPGER 1127
Query: 920 GPSAAQ--AGKQDDSGSSSEESDSDGEAPA 947
G + G Q G D PA
Sbjct: 1128 GLKGHRGFTGLQGLPGPPGPSGDQGASGPA 1157
Score = 57.8 bits (138), Expect = 5e-08
Identities = 108/443 (24%), Positives = 139/443 (31%), Gaps = 81/443 (18%)
Query: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361
A SA A+G PG+ PPG AG AG P D + P AK
Sbjct: 812 AGSAGARGAPGERGETGPPGPAGF------AGPPGADGQ-------------PGAKG--- 849
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAP-APPGKTGPAVAKAQAGKREED------SQSSS 414
G+ Q G A AP + P P P G TGP A+ G +
Sbjct: 850 --EQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGP 907
Query: 415 EESDSEEEAPAQAKPSGK-APQ-VRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
S+ P PSGK P+ R S P P + P GP + + G
Sbjct: 908 PGSNGNPGPPGPPGPSGKDGPKGARGDSGP----PGRAGEPGLQGPAGPPGEKGEPG--- 960
Query: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK-GA---------- 521
D S E + LA P + + P G GK GA
Sbjct: 961 -DDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPP 1019
Query: 522 GPV-PPGKVGPATPSAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQA 578
GPV PPG GPA + G D + ++ GE AP G+ A
Sbjct: 1020 GPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPA 1079
Query: 579 KPT-------SSPAKGPPQKAGPV---AVQVKAEKPMDNSESSEESS------------D 616
PT + A+GP +GP +Q D E+ E
Sbjct: 1080 GPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQ 1139
Query: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
P+ A P+ P + A P +G PR T PA
Sbjct: 1140 GLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPA 1199
Query: 677 G--SSPAVAG--GTQRPAEDSSS 695
G +P G G P D S+
Sbjct: 1200 GPPGNPGPPGPPGPPGPGIDMSA 1222
Score = 55.1 bits (131), Expect = 3e-07
Identities = 152/741 (20%), Positives = 217/741 (29%), Gaps = 124/741 (16%)
Query: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
G+ GD+ + G PP + E+ + G + E+ AP G R +
Sbjct: 107 GEPGDIK-DIVGPKGPPGPQGPAGEQ-GPRGDRGDKGEKGAP-GPRGR--------DGEP 155
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
+ G PG P PPG G A+Q G E+ A ++Q
Sbjct: 156 GTPGNPGPPGPPGPPGPPGLGGNFAAQMAGG--------------FDEKAGGAQLGVMQG 201
Query: 363 KAS--GKTSQVGAASAPAKE----SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
G G A AP + +P + P G GP GK +D ++
Sbjct: 202 PMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPG 261
Query: 417 SDSEEEAPAQAKPSG-----KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQ 471
E P G P V+ KG A AP G G+
Sbjct: 262 KAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAP----GVKGESGSPGEN 317
Query: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-MGPLGKGAGPVPPGKVG 530
+R AA + G Q PA G +GP G P PG G
Sbjct: 318 GSPGPMGPRGLPGERGRTGPAGAAGAR--GNDGQPGPAGPPGPVGPAGGPGFPGAPGAKG 375
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 590
A P+ G E + GE T +P + GN P + G
Sbjct: 376 EAGPTGARG----------PEGAQGPRGEPGTPGSPGPAGASGN-----PGTDGIPGAKG 420
Query: 591 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
AG + A P A P T +P + + + PK
Sbjct: 421 SAGAPGI---AGAPGFPGPRGPPGPQGATGPLGPKGQT---GEPGIAGFKGEQGPKGEPG 474
Query: 651 TASAKVAPVRVGTQAPRKAGTATSPAGSSP-------AVAGGTQRPAEDS-SSSEESDSE 702
A + AP G + K G P G P G P +D + + + E
Sbjct: 475 PAGPQGAPGPAGEEG--KRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGE 532
Query: 703 EEKTGLAVTVGQAKSVG----------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPT-- 750
+GLA G G +GL + +G +G AP G+ GP
Sbjct: 533 RGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGP 592
Query: 751 --------VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802
V K + E + A + +T A P A
Sbjct: 593 QGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGE 652
Query: 803 KGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 862
+G APG Q P PP + G A P +
Sbjct: 653 RGEQGAPG------PSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL-----------V 695
Query: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT-PPGKTGP 921
GP + G E + + P P + P+ + P PPG GP
Sbjct: 696 GPRGERGFPGERGSPGAQGLQGPRGLPG----------TPGTDGPKGASGPAGPPGAQGP 745
Query: 922 SAAQA--GKQDDSGSSSEESD 940
Q G++ +G + + D
Sbjct: 746 PGLQGMPGERGAAGIAGPKGD 766
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/298 (23%), Positives = 86/298 (28%), Gaps = 39/298 (13%)
Query: 183 GAAAKPGMVSAGQADSSSEDTSSSSD-ETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241
G A +PG+ G A E D + EG P + + V + P
Sbjct: 939 GRAGEPGL--QGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPG 996
Query: 242 -------PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
PGK G P G PP P + E G E A A
Sbjct: 997 LPGPSGEPGKQG--APGASGDRGPPGP-VGPPGLTGPAGEPGREGSPGADGPPGRDGAAG 1053
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
K + + A G PG +P P G G + +AG S P
Sbjct: 1054 VKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSG-----------P 1102
Query: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKG--------AAPAPPGKTGPAVAKAQA--- 403
A +Q G G A P E KG P PPG +G A A
Sbjct: 1103 AGARGIQG-PQGPRGDKGEAGEPG-ERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPS 1160
Query: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGP 461
G R D P P G P+ R+ P P PP GP
Sbjct: 1161 GPRGPPGPVGPSGKDGANGIPGPIGPPG--PRGRSGETGPAGPPGNPGPPGPPGPPGP 1216
>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 1418
Score = 84.7 bits (208), Expect = 4e-16
Identities = 181/821 (22%), Positives = 254/821 (30%), Gaps = 125/821 (15%)
Query: 214 GKPSVKPAQVKASSVSTKESPARKAAPA-PGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
GKP K + P + A PG G P VKG P K E +
Sbjct: 180 GKPGDDGEAGKPGKAGERGPPGPQGARGFPGTPG--LPGVKGHRGYPGLDGAKGEAGAPG 237
Query: 273 --SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQT 330
E GS E +P + E+ A +A A+G G+ PPG G
Sbjct: 238 VKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPG 297
Query: 331 KAGKPEEDSES--------SSEESSDSEEETPAAKALLQAK----------ASGKTSQVG 372
G P E+ + E TP + A A G G
Sbjct: 298 FPGAPGAKGEAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPG 357
Query: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGK 432
A AP PR P P G TGP K Q G E + + + P A P G
Sbjct: 358 IAGAPGFPGPR--GPPGPQGATGPLGPKGQTG---EPGIAGFKGEQGPKGEPGPAGPQG- 411
Query: 433 APQVRAASAPAKESPRKGA-----APAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDR- 486
A PA E ++GA P G A G +D + + + +R
Sbjct: 412 ------APGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERG 465
Query: 487 -EALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
LA A P G+ + P G G+ P GKVGP+ + G+
Sbjct: 466 PSGLAGPKGANGDP-GRPGE--PGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPG 522
Query: 546 ESSSEESSDSSDGEVPTAV----APAQEKSLGNI-----LQAKPTSSPAKGPPQKAGPVA 596
+ P A EK L L K + A GPP AGP
Sbjct: 523 PQGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAG 582
Query: 597 VQVKAEKPMDN------------SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKAC 644
+ + P + E + E + + + P +
Sbjct: 583 ERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERG--FPGERGS 640
Query: 645 PKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS--PAVAG--------GTQRPAED-- 692
P + P GT P+ A P G+ P + G G P D
Sbjct: 641 P-GAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRG 699
Query: 693 ---SSSSEESDSEEEKTGLAVTVGQAKSVG-KGLQVKAASVPVKGSLGQGTAPVLPGKTG 748
E + ++ GL +G G G + + GS G AP G+TG
Sbjct: 700 DVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGARGAPGERGETG 759
Query: 749 PT-----VTQVKAEKQEDSESSEEESDSEEAAASPA----------QVKTSVKKTQ---- 789
P A+ Q ++ + E+ + A +P Q T V +
Sbjct: 760 PPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 819
Query: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
A+ P A P A G + PG +P PP + ++ ARG + P
Sbjct: 820 AQGPPGATGFPGAAGRVGPPG---------SNGNPGPPGPPGPSGKDGPKGARGDSGPP- 869
Query: 850 VGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRK 909
G+A Q GP + G ++ S E P G Q P + R
Sbjct: 870 -GRAGEPGLQGPAGPPGEKGEPGDDGPSGAEGPP----GPQGLAGQRGIVGLPGQRGERG 924
Query: 910 GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT 950
PG GPS + GKQ G+S + P +T
Sbjct: 925 F-----PGLPGPS-GEPGKQGAPGASGDRGPPGPVGPPGLT 959
Score = 69.3 bits (168), Expect = 2e-11
Identities = 187/870 (21%), Positives = 248/870 (28%), Gaps = 141/870 (16%)
Query: 131 KAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGM 190
+AG TG P A G G A + T + + GS A G A PG
Sbjct: 307 EAGPTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAK--GSAGAPGIAGAPGF 364
Query: 191 VS--------------AGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
+ + + E +G+P PA + + E R
Sbjct: 365 PGPRGPPGPQGATGPLGPKGQTGEPGIAGFKGEQGPKGEPG--PAGPQGAPGPAGEEGKR 422
Query: 237 KAAPAPGKVGDVTPQVKGGALPPAKRA-----------KKPEEESESSEEGSESEEEAPA 285
A PG VG + P + GA P R P E S G + P
Sbjct: 423 GARGEPGGVGPIGPPGERGA--PGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPG 480
Query: 286 GTRSQVKASEKILQVRAASAPAKG------TPGKGATPAPPGKAGAVASQTKAGKPEEDS 339
+ L R A +G PG+ P PPG GA G P
Sbjct: 481 RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKG 540
Query: 340 ESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR----KGAAPAPPGKTG 395
++ E E+ P A L GK + GAA P P + AP P G G
Sbjct: 541 -ANGEPGKAGEKGLPGAPGL--RGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQG 597
Query: 396 PAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKA--PQVRAA-SAPAKESPRKGAA 452
G E + + E AP P G+ P R + A + PR
Sbjct: 598 ---LPGPPGPPGEGGKPGDQGVPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPR--GL 652
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREA--LAAMNAAQVKPLGKSPQVKPAS 510
P P GP A G + +R A +A + K P+ P
Sbjct: 653 PGTPGTDGPKGASGPAGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGK 712
Query: 511 TMGMGPLGKGAGPVPPG------KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
G G G P P G +VGP P+ G + E G A
Sbjct: 713 DGGRGLTGPIGPPGPAGANGEKGEVGPPGPAGSAGA----RGAPGERGETGPPGPAGFAG 768
Query: 565 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624
P + G AKG +AG A P S P
Sbjct: 769 PPGADGQPG-----------AKGEQGEAGQKG---DAGAPGPQGPSGAPGPQGPTGVTGP 814
Query: 625 AAMTAAQAKP-ALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS-- 679
AQ P A P + P +N P G P+ A + P G +
Sbjct: 815 KGARGAQGPPGATGFPGAAGRVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPPGRAGE 874
Query: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739
P + G P E ++ S E +GL + V + G G+
Sbjct: 875 PGLQGPAGPPGEKGEPGDDGPSGAE----------GPPGPQGLAGQRGIVGLPGQRGERG 924
Query: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799
P LPG +G Q P A+
Sbjct: 925 FPGLPGPSGEPGKQ--------------------------------------GAPGASGD 946
Query: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859
G + PG A ++ SP PP R+ RG +VG A
Sbjct: 947 RGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETG--AVGAPGAPGPP 1004
Query: 860 AQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT 919
GP +G + EA + PSG R P KG A PG+
Sbjct: 1005 GSPGPAGPTGKQGDRG----EAGAQGPMGPSGPA-GARGIQGPQGPRGDKGEA-GEPGER 1058
Query: 920 GPSAAQ--AGKQDDSGSSSEESDSDGEAPA 947
G + G Q G D PA
Sbjct: 1059 GLKGHRGFTGLQGLPGPPGPSGDQGASGPA 1088
Score = 57.8 bits (138), Expect = 5e-08
Identities = 108/443 (24%), Positives = 139/443 (31%), Gaps = 81/443 (18%)
Query: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361
A SA A+G PG+ PPG AG AG P D + P AK
Sbjct: 743 AGSAGARGAPGERGETGPPGPAGF------AGPPGADGQ-------------PGAKG--- 780
Query: 362 AKASGKTSQVGAASAPAKESPRKGAAP-APPGKTGPAVAKAQAGKREED------SQSSS 414
G+ Q G A AP + P P P G TGP A+ G +
Sbjct: 781 --EQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGP 838
Query: 415 EESDSEEEAPAQAKPSGK-APQ-VRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 472
S+ P PSGK P+ R S P P + P GP + + G
Sbjct: 839 PGSNGNPGPPGPPGPSGKDGPKGARGDSGP----PGRAGEPGLQGPAGPPGEKGEPG--- 891
Query: 473 EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK-GA---------- 521
D S E + LA P + + P G GK GA
Sbjct: 892 -DDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPP 950
Query: 522 GPV-PPGKVGPATPSAQVGKWEEDSESSSEESS--DSSDGEVPTAVAPAQEKSLGNILQA 578
GPV PPG GPA + G D + ++ GE AP G+ A
Sbjct: 951 GPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAPGAPGPPGSPGPA 1010
Query: 579 KPT-------SSPAKGPPQKAGPV---AVQVKAEKPMDNSESSEESS------------D 616
PT + A+GP +GP +Q D E+ E
Sbjct: 1011 GPTGKQGDRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFTGLQ 1070
Query: 617 SADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
P+ A P+ P + A P +G PR T PA
Sbjct: 1071 GLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGANGIPGPIGPPGPRGRSGETGPA 1130
Query: 677 G--SSPAVAG--GTQRPAEDSSS 695
G +P G G P D S+
Sbjct: 1131 GPPGNPGPPGPPGPPGPGIDMSA 1153
Score = 55.1 bits (131), Expect = 3e-07
Identities = 152/741 (20%), Positives = 217/741 (29%), Gaps = 124/741 (16%)
Query: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
G+ GD+ + G PP + E+ + G + E+ AP G R +
Sbjct: 38 GEPGDIK-DIVGPKGPPGPQGPAGEQ-GPRGDRGDKGEKGAP-GPRGR--------DGEP 86
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
+ G PG P PPG G A+Q G E+ A ++Q
Sbjct: 87 GTPGNPGPPGPPGPPGPPGLGGNFAAQMAGG--------------FDEKAGGAQLGVMQG 132
Query: 363 KAS--GKTSQVGAASAPAKE----SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
G G A AP + +P + P G GP GK +D ++
Sbjct: 133 PMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPG 192
Query: 417 SDSEEEAPAQAKPSG-----KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQ 471
E P G P V+ KG A AP G G+
Sbjct: 193 KAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAP----GVKGESGSPGEN 248
Query: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG-MGPLGKGAGPVPPGKVG 530
+R AA + G Q PA G +GP G P PG G
Sbjct: 249 GSPGPMGPRGLPGERGRTGPAGAAGAR--GNDGQPGPAGPPGPVGPAGGPGFPGAPGAKG 306
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQ 590
A P+ G E + GE T +P + GN P + G
Sbjct: 307 EAGPTGARG----------PEGAQGPRGEPGTPGSPGPAGASGN-----PGTDGIPGAKG 351
Query: 591 KAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
AG + A P A P T +P + + + PK
Sbjct: 352 SAGAPGI---AGAPGFPGPRGPPGPQGATGPLGPKGQT---GEPGIAGFKGEQGPKGEPG 405
Query: 651 TASAKVAPVRVGTQAPRKAGTATSPAGSSP-------AVAGGTQRPAEDS-SSSEESDSE 702
A + AP G + K G P G P G P +D + + + E
Sbjct: 406 PAGPQGAPGPAGEEG--KRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGE 463
Query: 703 EEKTGLAVTVGQAKSVG----------KGLQVKAASVPVKGSLGQGTAPVLPGKTGPT-- 750
+GLA G G +GL + +G +G AP G+ GP
Sbjct: 464 RGPSGLAGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGP 523
Query: 751 --------VTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 802
V K + E + A + +T A P A
Sbjct: 524 QGARGQPGVMGFPGPKGANGEPGKAGEKGLPGAPGLRGLPGKDGETGAAGPPGPAGPAGE 583
Query: 803 KGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQT 862
+G APG Q P PP + G A P +
Sbjct: 584 RGEQGAPG------PSGFQGLPGPPGPPGEGGKPGDQGVPGEAGAPGL-----------V 626
Query: 863 GPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPT-PPGKTGP 921
GP + G E + + P P + P+ + P PPG GP
Sbjct: 627 GPRGERGFPGERGSPGAQGLQGPRGLPG----------TPGTDGPKGASGPAGPPGAQGP 676
Query: 922 SAAQA--GKQDDSGSSSEESD 940
Q G++ +G + + D
Sbjct: 677 PGLQGMPGERGAAGIAGPKGD 697
Score = 42.4 bits (98), Expect = 0.002
Identities = 70/298 (23%), Positives = 86/298 (28%), Gaps = 39/298 (13%)
Query: 183 GAAAKPGMVSAGQADSSSEDTSSSSD-ETDVEGKPSVKPAQVKASSVSTKESPARKAAPA 241
G A +PG+ G A E D + EG P + + V + P
Sbjct: 870 GRAGEPGL--QGPAGPPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPG 927
Query: 242 -------PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
PGK G P G PP P + E G E A A
Sbjct: 928 LPGPSGEPGKQG--APGASGDRGPPGP-VGPPGLTGPAGEPGREGSPGADGPPGRDGAAG 984
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
K + + A G PG +P P G G + +AG S P
Sbjct: 985 VKGDRGETGAVGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSG-----------P 1033
Query: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKG--------AAPAPPGKTGPAVAKAQA--- 403
A +Q G G A P E KG P PPG +G A A
Sbjct: 1034 AGARGIQG-PQGPRGDKGEAGEPG-ERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPS 1091
Query: 404 GKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGP 461
G R D P P G P+ R+ P P PP GP
Sbjct: 1092 GPRGPPGPVGPSGKDGANGIPGPIGPPG--PRGRSGETGPAGPPGNPGPPGPPGPPGP 1147
>gi|148806908 fibronectin type III domain containing 1 [Homo sapiens]
Length = 1894
Score = 82.8 bits (203), Expect = 1e-15
Identities = 192/854 (22%), Positives = 310/854 (36%), Gaps = 142/854 (16%)
Query: 203 TSSSSD---ETDVEGKPSV-KPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALP 258
T+S +D T+ GKP +P+ + ++ + P+ A+P D+ +K L
Sbjct: 456 TTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILA 515
Query: 259 PAKRAKKPEEESESSEE----GSESEEEAPAGTR--SQVKASEKILQVRAASAPAKG--- 309
+KP+ ++ +EE +E E G+R S + S+ Q R P++
Sbjct: 516 NGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHS 575
Query: 310 --TPGKGAT----PAPPGKAG------AVASQTKAGKPEEDSESSSEESS---------- 347
PG+ A PA P + G ++A+Q + G P S S + +S
Sbjct: 576 VVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHASTQGTSHRPSL 635
Query: 348 ----------DSEEETPAAKALLQAKASGKTSQVGAASAPAKESP----------RKGAA 387
DS+E+ A +L G +Q A +P+++SP GA
Sbjct: 636 PASLNDNDLVDSDEDERAVGSL---HPKGAFAQPRPALSPSRQSPSSVLRDRSSVHPGAK 692
Query: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
PA P + P +G EEDS +S+ S +P S P S+P +
Sbjct: 693 PASPARRTP-----HSGAAEEDSSASAPPS---RLSPPHGGSSRLLPTQPHLSSPLSKGG 744
Query: 448 RKGA-AP-----APPRKTGPAA--------AQVQVGKQEED--SRSSSEESDSDREALAA 491
+ G AP AP R T ++ QV G + D S + D R+A A
Sbjct: 745 KDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGGRQAEAT 804
Query: 492 MNAAQVKPLGKSPQV---KPASTMGMGP----LGKGAGPVPPGKVGPATPSAQVGKWEED 544
+ +P + KP + G P +G+G P PS +
Sbjct: 805 AQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSRAHPRVPSH 864
Query: 545 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 604
S+S + SS E PA ++ SS + + + +
Sbjct: 865 SDSHPKLSSGIHGDEEDEKPLPA------TVVNDHVPSSSRQPISRGWEDLRRSPQRGAS 918
Query: 605 MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQT----------KACPKKTNTTASA 654
+ E E+ S ++ P ++ A A + Q+ KA P T+ AS
Sbjct: 919 LHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGSTDRHASP 978
Query: 655 KVAPVRVGTQ---APRKAGTATSPAGS-SPAVAGGTQRPAEDSSSSEESDSEEEKTGLAV 710
P Q PR+ +P P VA P S + S S+ L++
Sbjct: 979 ARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQPR---LSL 1035
Query: 711 T-VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
T G+ + +G + ++S P S +G P T A+ D +S+E E+
Sbjct: 1036 TQAGRPRPTSQG-RSHSSSDPYTAS-SRGMLP-----TALQNQDEDAQGSYDDDSTEVEA 1088
Query: 770 DSEEAAASPAQVK---TSVKKTQAKANPAAARA----------PSAKGTISAPGKVVTAA 816
A A A+ K S+ K Q +P A A ++ S PG + A
Sbjct: 1089 QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQSRA 1148
Query: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEE-- 874
+ +P K +PP + P +S + SV + A + G E+ SS +
Sbjct: 1149 RVPSRAAPGKSEPPSKRPLSS----KSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP 1204
Query: 875 SDSEEEAETLAQVKPSGKTHQIRAALAPAKES--PRKGAAPTPPGKTGPSAAQAGKQDDS 932
S S A + + + ALAP S P K P PPG + P A+ +
Sbjct: 1205 SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPG-SSPRASHVPSRLPP 1263
Query: 933 GSSSEESDSDGEAP 946
S++ S G P
Sbjct: 1264 RSAATVSPVAGTHP 1277
Score = 54.3 bits (129), Expect = 5e-07
Identities = 126/672 (18%), Positives = 221/672 (32%), Gaps = 126/672 (18%)
Query: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
+R + A+L K+ +P ST + + + + +KA ST++ G +
Sbjct: 910 RRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQP 969
Query: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS---ETEEEGS 178
+ + S HP+ + + G++P++ P T+ ++ + G
Sbjct: 970 GSTDRHASPARPPAARSQQHPSVPR---RMTPGRAPQQQPPPPVATSQHHPGPQSRDAGR 1026
Query: 179 VPA-----FGAAAKPGMVSAGQADSSSEDTSSSS---------------------DETDV 212
P+ A +P S G++ SSS+ ++SS D T+V
Sbjct: 1027 SPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEV 1086
Query: 213 EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
E + PA + + P + +P G GG + S+
Sbjct: 1087 EAQDVRAPAHAARAKEAAASLPKHQQVESPTGAG------AGG-----------DHRSQR 1129
Query: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
S + P G +S+ A P++ PGK PP K + ++
Sbjct: 1130 GHAASPARPSRPGGPQSR------------ARVPSRAAPGKS---EPPSKRPLSSKSQQS 1174
Query: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392
E+D E + +E+ ++ +S A + AKE A AP G
Sbjct: 1175 VSAEDDEEEDAGFFKGGKEDLLSSSVPKWPSSSTPRGGKDADGSLAKEEREPAIALAPRG 1234
Query: 393 KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452
+ V + P G +P RA+ P++ PR A
Sbjct: 1235 GSLAPVKR------------------------PLPPPPGSSP--RASHVPSRLPPRSAAT 1268
Query: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM 512
+P T P Q + S+ S R+ + M+A PL + P +P+
Sbjct: 1269 VSPVAGTHP---WPQYTTRAPPGHFSTTPMLSLRQRM--MHARFRNPLSRQP-ARPSYRQ 1322
Query: 513 GMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL 572
G P GKV P + G+ + ++ D G V A + S
Sbjct: 1323 GY-----NGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSH 1377
Query: 573 GNILQAK------------------PTSSPAKGPPQKAGPVA------VQVKAEKPMDNS 608
GN L+ K P P G + P+A + KP+
Sbjct: 1378 GNPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGL 1437
Query: 609 ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRK 668
E ++++ + P T P T A ++T TT + +
Sbjct: 1438 EVIKKTTHPPTTTMQPTTTTTPLPTTTTPRP-TTATTRRTTTTRRTTTRRPTTTVRTTTR 1496
Query: 669 AGTATSPAGSSP 680
T T+P ++P
Sbjct: 1497 TTTTTTPTPTTP 1508
>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
Length = 1464
Score = 81.6 bits (200), Expect = 3e-15
Identities = 166/734 (22%), Positives = 211/734 (28%), Gaps = 98/734 (13%)
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
A AA PG G P GA+ A +G E P + A
Sbjct: 327 ATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAG 386
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
+ + A G PG P PG G Q G P + + E P
Sbjct: 387 NPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPP-------GPKGNSGEPGAP 439
Query: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKTGPAVAKAQAGKR---EED 409
+K AK V PA E ++GA P P G GP + G R D
Sbjct: 440 GSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGAD 499
Query: 410 SQSSSEESDSEEEAPAQAKPSGKAPQV----RAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
+ + E +P A P G + A AK +P P KTGP
Sbjct: 500 GVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPP--- 556
Query: 466 VQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVP 525
G +D R R M K P G G+ P P
Sbjct: 557 ---GPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEP----------GKAGERGVPGP 603
Query: 526 PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA 585
PG VGPA DGE P G + P SP
Sbjct: 604 PGAVGPA----------------------GKDGEAGAQGPPGPAGPAGERGEQGPAGSPG 641
Query: 586 -KGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQ-TKA 643
+G P AGP K + + A E Q P P+
Sbjct: 642 FQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANG 701
Query: 644 CPKKTNTTASAKVAPVRVGTQA-------PRKAGTATSPAGSSPAVAGGTQRPAEDSSSS 696
P A AP G+Q P + G A P P G P + + S
Sbjct: 702 APGNDGAKGDAG-APGAPGSQGAPGLQGMPGERGAAGLP---GPKGDRGDAGP-KGADGS 756
Query: 697 EESDSEEEKTGLAVTVGQAKSVG----KGLQVKAASVPVKGSLGQGTAPVLPGKTG---- 748
D TG G A + G G A +G+ G P PG G
Sbjct: 757 PGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGP 816
Query: 749 PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK---TSVKKTQAKANPAAARAPSAKGT 805
P K E ++ + A PA +V AK +A P A G
Sbjct: 817 PGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGF 876
Query: 806 ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
A G+V P P + GPA P + GP
Sbjct: 877 PGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRP-----------GEVGPP 925
Query: 866 EDSGSSEEESD--SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSA 923
G + E+ ++ A P G Q P + R PG GPS
Sbjct: 926 GPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGF-----PGLPGPS- 979
Query: 924 AQAGKQDDSGSSSE 937
+ GKQ SG+S E
Sbjct: 980 GEPGKQGPSGASGE 993
Score = 68.6 bits (166), Expect = 3e-11
Identities = 124/507 (24%), Positives = 157/507 (30%), Gaps = 51/507 (10%)
Query: 113 LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRK--SAEPSANTTLV 170
LGA PS A+ E G+ G P G AN G K + P A +
Sbjct: 667 LGAPGPSG----ARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQ- 721
Query: 171 SETEEEGSVPAFGAAAKPGMVS-AGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVS 229
+G GAA PG G A D S D P P A
Sbjct: 722 GAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDK 781
Query: 230 TKESPARKAAP-----APGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
+ P+ A P APG G+ P G P +P + E + G++ + P
Sbjct: 782 GESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDA-GP 840
Query: 285 AGTRSQVKASEKILQVRAASAP----AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 340
G I V A A + G PG P G+ G AG P
Sbjct: 841 PGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGP 900
Query: 341 SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAK 400
+ E ET A + G G +P + P AP PG G A +
Sbjct: 901 AGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGP--AGAPGTPGPQGIAGQR 958
Query: 401 AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAP----APP 456
G + E P PSG+ + + A + P P PP
Sbjct: 959 GVVGLPGQRG---------ERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPP 1009
Query: 457 RKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG--- 513
++G A G D S + D A A P P V PA G
Sbjct: 1010 GESGREGAPGAEGSPGRDG-SPGAKGDRGETGPAGPPGAPGAPGAPGP-VGPAGKSGDRG 1067
Query: 514 -MGPLGKGAGPVPP-GKVGPATPSAQVGKWEEDSES-----SSEESSDSSDGEVPTAVAP 566
GP G AGPV P G GPA P G E E G +P
Sbjct: 1068 ETGPAGP-AGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSP 1126
Query: 567 AQEKSLGNILQAKPTSSPAKGPPQKAG 593
++ G A P +GPP AG
Sbjct: 1127 GEQGPSGASGPAGP-----RGPPGSAG 1148
Score = 66.6 bits (161), Expect = 1e-10
Identities = 149/669 (22%), Positives = 197/669 (29%), Gaps = 98/669 (14%)
Query: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
A G G P PPGK G K G+P E + P L K
Sbjct: 213 ASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQ----GARGLPGTAGLPGMKGHR 268
Query: 367 KTSQVGAASAPAKESPRKGAAPAP-----PGKTGPAVAKAQAGKREEDSQSSSEESDSEE 421
S + A A + KG +P PG+ GP + G+ + + +D
Sbjct: 269 GFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGAT 328
Query: 422 EAPAQAKPSGKA------PQVRAASAPAKESPRKGAAP----APPRKTGPAAAQVQVGKQ 471
A P+G A V A + PR P P GPA A G
Sbjct: 329 GAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNP 388
Query: 472 EEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVG- 530
D + ++ ++ + A P + P GP G G P P G G
Sbjct: 389 GADGQPGAKGAN----GAPGIAGAPGFPGARGPS---------GPQGPGGPPGPKGNSGE 435
Query: 531 PATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPP- 589
P P + + D+ + E G A +E G + PT P GPP
Sbjct: 436 PGAPGS-----KGDTGAKGEPGPVGVQGPPGPA---GEEGKRGARGEPGPTGLP--GPPG 485
Query: 590 QKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTN 649
++ GP AD P + P P K P +
Sbjct: 486 ERGGP----------------GSRGFPGADGVAGPKGPAGERGSPGPAGP--KGSPGEAG 527
Query: 650 TTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLA 709
A + P G SP P G PA D G
Sbjct: 528 RPGEAGL---------PGAKGLTGSPGSPGPDGKTGPPGPA-------GQDGRPGPPGPP 571
Query: 710 VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQ---------- 759
GQA +G AA P G G+ P PG GP +A Q
Sbjct: 572 GARGQAGVMGFPGPKGAAGEP--GKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAG 629
Query: 760 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
E E S + PA K + P AP G A G+ +
Sbjct: 630 ERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSG---ARGERGFPGERG 686
Query: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSV-GKAVATAAQAQTGPEEDSGSSEEESDSE 878
Q P P N A+G A P G A Q G +G + D
Sbjct: 687 VQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRG 746
Query: 879 EEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEE 938
+ A P GK +R P P AP G++GPS AG G+ +
Sbjct: 747 DAGPKGADGSP-GK-DGVRGLTGPI-GPPGPAGAPGDKGESGPS-GPAGPTGARGAPGDR 802
Query: 939 SDSDGEAPA 947
+ PA
Sbjct: 803 GEPGPPGPA 811
Score = 63.9 bits (154), Expect = 7e-10
Identities = 136/619 (21%), Positives = 187/619 (30%), Gaps = 95/619 (15%)
Query: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-A 241
GA PG A + D+ + S ++G P + A + K A +
Sbjct: 698 GANGAPGNDGA-KGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGS 756
Query: 242 PGKVGDVTPQVKG--GALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
PGK G V+G G + P A P ++ ES G PAG
Sbjct: 757 PGKDG-----VRGLTGPIGPPGPAGAPGDKGESGPSG-------PAGPTG---------- 794
Query: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE-SSSEESSDSEEETPAAKA 358
A+G PG P PPG AG G+P E + D+ PA A
Sbjct: 795 -------ARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPA 847
Query: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 418
G +G AP + R A P PG TG A + G S
Sbjct: 848 -------GPPGPIGNVGAPGAKGARGSAGP--PGATGFPGAAGRVGP----PGPSGNAGP 894
Query: 419 SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
PA K GK P R + PA P + P PP G + G
Sbjct: 895 PGPPGPA-GKEGGKGP--RGETGPAGR-PGEVGPPGPPGPAGEKGSPGADGPAGAPGTPG 950
Query: 479 SEESDSDREA--LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
+ R L + P P +P GP G PPG +GP +
Sbjct: 951 PQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGK---QGPSGASGERGPPGPMGPPGLAG 1007
Query: 537 QVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP-AKGPPQKAGPV 595
G+ S E + ++G +P + G A P +P A G P GP
Sbjct: 1008 PPGE-------SGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPA 1060
Query: 596 AVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAK 655
+S + P A+ + P+ K
Sbjct: 1061 ------------GKSGDRGETGPAGPAGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIK 1108
Query: 656 VAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQA 715
G Q P G SP P+ A G P S + ++ GL +G
Sbjct: 1109 GHRGFSGLQGP--PGPPGSPGEQGPSGASGPAGP-RGPPGSAGAPGKDGLNGLPGPIGPP 1165
Query: 716 KSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPT--------VTQVKAEKQEDSESSEE 767
G+ G +G P PG GP + Q EK D
Sbjct: 1166 GPRGR--------TGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRYYR 1217
Query: 768 ESDSEEAAASPAQVKTSVK 786
D+ +V T++K
Sbjct: 1218 ADDANVVRDRDLEVDTTLK 1236
Score = 56.6 bits (135), Expect = 1e-07
Identities = 100/427 (23%), Positives = 133/427 (31%), Gaps = 72/427 (16%)
Query: 125 AKAETEKAGKTGNSMPHPATGKT-----VANLLS--GKSPRKSAEPSANTTLVSETEEEG 177
AK E AG G++ P G + N+ + K R SA P T G
Sbjct: 825 AKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVG 884
Query: 178 SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP-AR 236
G A PG + E ET G+P K SP A
Sbjct: 885 PPGPSGNAGPPGP----PGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGAD 940
Query: 237 KAAPAPGKVGDVTPQVKGGALP-PAKRAKK--PEEESESSEEGSESEEEAPAGTRSQVKA 293
A APG G + G + P +R ++ P S E G ++ P+G +
Sbjct: 941 GPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPG----KQGPSGASGE--- 993
Query: 294 SEKILQVRAASAPAKGTPGKGATPA---PPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
+G PG P PPG++G + G P D ++ D
Sbjct: 994 --------------RGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAK--GDRG 1037
Query: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA-PPGKTGPAVAKAQAGKREED 409
E PA A G G K R PA P G GP A+ AG +
Sbjct: 1038 ETGPAGPP----GAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGARGPAGPQGPR 1093
Query: 410 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 469
+ SG +P ++ P + PA PR GP + G
Sbjct: 1094 GDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPR--GPPGSAGAPG 1151
Query: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV 529
K + P+G P T GP+G P PPG
Sbjct: 1152 KDGLNGLPG--------------------PIG--PPGPRGRTGDAGPVGPPGPPGPPGPP 1189
Query: 530 GPATPSA 536
GP PSA
Sbjct: 1190 GP--PSA 1194
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 79.3 bits (194), Expect = 2e-14
Identities = 170/828 (20%), Positives = 300/828 (36%), Gaps = 121/828 (14%)
Query: 188 PGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGD 247
P V+ +S+ ++ + VE + V+ ++VS + PA + APAP + +
Sbjct: 1639 PPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPVEQLE 1698
Query: 248 VTPQVKGGALPPAKRAKKPE--EESESSEEGSESEEEAPAGTRSQVKASEKI----LQVR 301
+ GA P + A P EE S ++ + + P S +A + +
Sbjct: 1699 QV-DLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757
Query: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA---KA 358
S PA+ + A A A A K E ES S D E + P A K
Sbjct: 1758 PLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKK 1817
Query: 359 LLQAKASGKTSQVGAASAPAKESPRKG---------AAPAPPGKTGPAVAKAQAGKREED 409
++K S Q A S K RK + +P G+ + ++
Sbjct: 1818 PNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITR 1877
Query: 410 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASA---------PAK---ESPR--------- 448
+ S + +D E P+ + VR+ A P K E PR
Sbjct: 1878 TASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERE 1937
Query: 449 ---KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEES----DSDREALAAMNAAQVKPLG 501
A P PR+ P + + ++EE+ E+ + R + AA P G
Sbjct: 1938 LQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQG 1997
Query: 502 K----SPQV---KPASTMGMGP-LGKGAGPVPPGKVGPATPSAQVGKWEE---------- 543
K P+V +P +T +GP +G + P S Q ++
Sbjct: 1998 KKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPET 2057
Query: 544 ------DSESSSEESSDSSDGEVPTA-VAPAQEKSLGNILQA-KPTSSPAKGPPQKAGPV 595
+ + + E++S S G + +A + SL N+ A P + A+ +++G V
Sbjct: 2058 APVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVV 2117
Query: 596 AVQ-VKAEKPM-DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653
AV K+E P ++ SS+ SD D ++ P + + P+ P+ K+ +
Sbjct: 2118 AVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPS---PEATQLAKQMELEQA 2174
Query: 654 AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG 713
+ ++ + A A +P G +P +PA +S +E LA +G
Sbjct: 2175 VEHI-AKLAEASASAAYKADAPEGLAPE---DRDKPAHQASETE----------LAAAIG 2220
Query: 714 QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQE---------DSES 764
S+ + + + P + L G Q E E ++E+
Sbjct: 2221 ---SIINDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEA 2277
Query: 765 SEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA--------PGKVVTAA 816
+ E S A P+ T K+ + ++ + P AKG+ G+ T
Sbjct: 2278 ATESSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTR 2337
Query: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 876
++ K+ + KV PV + + A+G + + G T Q P+E+ S + S
Sbjct: 2338 SRRKRNTNKKVVAPVESHVPESNQAQGESPAANEG----TTVQHPEAPQEEKQSEKPHST 2393
Query: 877 SEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAP---TPPGKTGP 921
+ + PS T ++ + +P K + P PP + P
Sbjct: 2394 PPQSCTSDLSKIPS--TENSSQEISVEERTPTKASVPPDLPPPPQPAP 2439
Score = 76.6 bits (187), Expect = 1e-13
Identities = 205/971 (21%), Positives = 336/971 (34%), Gaps = 141/971 (14%)
Query: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKA--------TPRLASTNSS-- 111
+R+ +E AA+ R P + + EEEE E A+ +PR T +
Sbjct: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGG 1994
Query: 112 ---VLGADLPSSMKEKAKAETEKAGKTG---NSMPHPATGKTVANLLSGKSPRKSAEPSA 165
G + P + +A TE + G +SM A + + K RK A
Sbjct: 1995 PQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGS--EQKRDRKDAGTDK 2052
Query: 166 NT--TLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQV 223
N T E E+ P + +K G + + D S+S D P AQ
Sbjct: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGR---SRNSRLAVDKSASLKNVDAAVSPRGAAAQA 2109
Query: 224 -KASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEE 282
+ S SP + +P K ++ Q+K + P K +PE+E S+ G E
Sbjct: 2110 GERESGVVAVSPEKSESPQ--KEDGLSSQLKSDPVDPDK---EPEKEDVSAS-GPSPEAT 2163
Query: 283 APAGTRSQVKASEKILQVRAASAPA--KGTPGKGATPAPPGKAGAVASQTK--------- 331
A +A E I ++ ASA A K +G P K AS+T+
Sbjct: 2164 QLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSII 2223
Query: 332 ---AGKPEE-DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
+G+PE + S ++ + PA LQ G + + E+ + +
Sbjct: 2224 NDISGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSR 2283
Query: 388 P---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEE----------------------- 421
P AP GP K G E S S E S+E
Sbjct: 2284 PPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRN 2343
Query: 422 -----------EAPAQAKPSGKAPQVR-AASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 469
P + G++P + E+P++ P T P + +
Sbjct: 2344 TNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLS 2403
Query: 470 KQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQV--KPASTMGMGPLGKGAGPVPPG 527
K SS E S +R A + P + V +P + + + + + PV P
Sbjct: 2404 KIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIE-SDPVTP- 2461
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEK---SLGNILQAKPTSSP 584
P+ PS + S ++++ S + G +P P + + +A+ T SP
Sbjct: 2462 ---PSDPSIPIPTLP--SVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSP 2516
Query: 585 AKGPPQKAGPVAVQVKA-------EKPMDNSESSEESSDSADSEEAPAAMTAAQAKP--- 634
A P KA V K + + + S +A +E AA +A P
Sbjct: 2517 ALPPDTKASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPV 2576
Query: 635 -ALKIPQTKACPKKTNTT---ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPA 690
+ K + K P TN + AS + AP A TS P +
Sbjct: 2577 DSKKPLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKITSVISRMPV--------S 2628
Query: 691 EDSSSSEE----SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ--------- 737
D +S++ + + TGL + +V + V A PVKGS+
Sbjct: 2629 IDLENSQKITLAKPAPQTLTGLVSALTGLVNVSL-VPVNALKGPVKGSVTTLKSLVSTPA 2687
Query: 738 GTAPVLPGK----TGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
G VL G TGP + AA++ ++V T
Sbjct: 2688 GPVNVLKGPVNVLTGPVNVLTTPVNATVGTVNAAPGTVNAAASAVNATASAVTVTAGAVT 2747
Query: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
A+ + GT++ G V+ + + KQR+ + +P + V+ PA G
Sbjct: 2748 AASGGVTATTGTVTMAGAVIAPSTKCKQRASANENSRF-HPGSMPVIDDRPA---DAGSG 2803
Query: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKP-SGKTHQIRAALAPAKESPRKGAA 912
G S S ++ + + ++Q+ P S + + +++ ++ P A
Sbjct: 2804 AGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKPDSVTA 2863
Query: 913 PTPPGKTGPSA 923
PP K GP A
Sbjct: 2864 SQPPSK-GPQA 2873
Score = 61.6 bits (148), Expect = 3e-09
Identities = 127/628 (20%), Positives = 230/628 (36%), Gaps = 107/628 (17%)
Query: 405 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA 464
++E++ +E + +E+ K AP+ + + S + ++ P+A
Sbjct: 1595 QKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSAL 1654
Query: 465 QVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGK-GAGP 523
+ G + ++ +EE V+P S + KPAS P+ +
Sbjct: 1655 EKTTGDKTVEAPLVTEEK-------------TVEPATVSEEAKPASEPAPAPVEQLEQVD 1701
Query: 524 VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS 583
+PPG P +A + E E SS + D + PT A + N+ ++
Sbjct: 1702 LPPG-ADPDKEAAMMPAGVE--EGSSGDQPPYLDAKPPTPGASFSQAE-SNVDPEPDSTQ 1757
Query: 584 PAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADS--EEAPAAMTAAQAKPALKIPQT 641
P P QK+ A + KAEKP +++ +++ A++ E P A + P +
Sbjct: 1758 PLSKPAQKS-EEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDK 1816
Query: 642 KACPKKTNTT----ASAKVAPVRVGTQAPR----KAGTATSPAGSSPAVAG---GTQRPA 690
K K + T A+ + V ++ R K + SP G + + ++
Sbjct: 1817 KPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKIT 1876
Query: 691 EDSSSSEESDSEEEKTGLAVTVGQ---AKSVGKGLQVKAASVPVKGSLGQ---------- 737
+S + +D E + L ++ + +SV + PVK + Q
Sbjct: 1877 RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLER 1936
Query: 738 -----GTAPVLPGKTGPTVTQVKAEKQEDSESSE--EESDSEEAAASPAQVKTS------ 784
P P + P T+ +A+++E++E+ E E E SP KT+
Sbjct: 1937 ELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQ 1996
Query: 785 --------------------------VKKTQAKANPAAARAPSAK-------GTISAPGK 811
VK++ + A A S + GT P +
Sbjct: 1997 GKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPE 2056
Query: 812 VVTAAAQAKQRSPSKVKPPVR-NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG- 869
K+ +P K R +NS + AS+ +V AV+ A E +SG
Sbjct: 2057 TAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGV 2116
Query: 870 --SSEEESDSEEEAETLAQVKPSGKTHQIRA-ALAPAKESPRKGAAPTPPGKTGPSAAQA 926
S E+S+S + K G + Q+++ + P KE ++ + + P P A Q
Sbjct: 2117 VAVSPEKSESPQ--------KEDGLSSQLKSDPVDPDKEPEKEDVSASGP---SPEATQL 2165
Query: 927 GKQDDSGSSSEESDSDGEAPAAVTSAQD 954
KQ + + E EA A+ D
Sbjct: 2166 AKQMELEQAVEHIAKLAEASASAAYKAD 2193
Score = 39.7 bits (91), Expect = 0.014
Identities = 91/415 (21%), Positives = 149/415 (35%), Gaps = 79/415 (19%)
Query: 54 QQTSELGRKRKAEEDAA-LQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSV 112
++ L RK K E+D Q +K +V P +S+SSE ++E E E + PR +
Sbjct: 803 ERERRLIRKEKVEKDKTDKQKRKGKVHSP--SSQSSETDQENEREQSPEKPRSCN----- 855
Query: 113 LGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSE 172
K EKA K G + R P T V E
Sbjct: 856 -------------KLSREKADKEGIA-----------------KNRLELMPCVVLTRVKE 885
Query: 173 TEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKE 232
E G V +A ++ SS+ ++ K V + S +S E
Sbjct: 886 KE--------GKVIDHTPVEKLKAKLDNDTVKSSA----LDQKLQVSQTEPAKSDLSKLE 933
Query: 233 SPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESE--SSEEGSESEEEAPAGTRSQ 290
S K G V K G L A++ KPE+ ++ S+ + + E S
Sbjct: 934 SVRMKVPKEKGLSSHVEVVEKEGRL-KARKHLKPEQPADGVSAVDLEKLEARKRRFADSN 992
Query: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
+KA ++ +V+ +S P + V S+ +P+ S
Sbjct: 993 LKAEKQKPEVKKSS--------------PEMEDARVLSKK---QPDVSSREVILLREGEA 1035
Query: 351 EETPAAKALLQAKASG-KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409
E P K +L+ ++ K ++ ++P K+ + G + +A+ G E
Sbjct: 1036 ERKPVRKEILKRESKKIKLDRLNTVASP-KDCQELASISVGSGSRPSSDLQARLG---EL 1091
Query: 410 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA----PAPPRKTG 460
+ S E + + + P +KP K QV P +E RK P RK+G
Sbjct: 1092 AGESVENQEVQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSG 1146
Score = 33.9 bits (76), Expect = 0.75
Identities = 34/139 (24%), Positives = 58/139 (41%), Gaps = 29/139 (20%)
Query: 247 DVTPQVKGGALPPAKRAKKPEEESES-SEEGSESEEEAPAGTRSQVKASEKILQVRAASA 305
D+T +V+G +R ++ + S S S S+S ++P SQ AS
Sbjct: 223 DITREVRG------RRPERNYQHSRSRSPHSSQSRNQSPQRLASQ------------ASR 264
Query: 306 PAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKAS 365
P + G G+ +S + + + S SSS++S A+++ A
Sbjct: 265 PTRSPSGSGSRSRSSSSDSISSSSSTSSDSSDSSSSSSDDS--------PARSVQSAAVP 316
Query: 366 GKTSQVGAASAPAKESPRK 384
TSQ+ S+ K+ PRK
Sbjct: 317 APTSQL--LSSLEKDEPRK 333
Score = 32.0 bits (71), Expect = 2.8
Identities = 73/361 (20%), Positives = 118/361 (32%), Gaps = 53/361 (14%)
Query: 69 AALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAE 128
+++ +++ + P S +++ ++ E TP L S S+ L S +
Sbjct: 3069 SSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTLPSITYSIRPEALHSPRAPLQPQQ 3128
Query: 129 TEKAGKTGNSMPHPATGKTVANLLSGKSPR----------KSAEPSANTTLVSETE---E 175
E S P PA A L S P ++ P + LV ++E
Sbjct: 3129 IEVRAPQRASTPQPAPAGVPA-LASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEYRLH 3187
Query: 176 EGSVPAFGAAAKPGMVSAGQADSSSED----TSSSSDETDVEGKPSVKPAQVKASSVSTK 231
+VP V+A + D +S GK + K KA+ T
Sbjct: 3188 PYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPTPTP 3247
Query: 232 ES---PARKAAPAPGKVGD-----VTP--QVKGGALPPAKRAKKPEEESESSEE------ 275
P APAP G+ VTP Q++G L P + SS E
Sbjct: 3248 APVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQEYR 3307
Query: 276 -GSESEEEAPAG-TRSQVKASEKILQVRAASAPAKGTPGKG-----------------AT 316
G PA T +Q A+ + A+G P +G A
Sbjct: 3308 YGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQPAP 3367
Query: 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
P PP + G + P+ E+ ++ + PA A + + + A +
Sbjct: 3368 PCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRPPEPHTQVQRAQAETG 3427
Query: 377 P 377
P
Sbjct: 3428 P 3428
>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
Length = 1466
Score = 78.6 bits (192), Expect = 3e-14
Identities = 183/795 (23%), Positives = 228/795 (28%), Gaps = 124/795 (15%)
Query: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAP 242
G A +PG A E + G P K K S E A A
Sbjct: 429 GGAGEPGKNGA----KGEPGPRGERGEAGIPGVPGAKGEDGKDGSPG--EPGANGLPGAA 482
Query: 243 GKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRA 302
G+ G P +G A P P E+ + E G+ PAG R A E
Sbjct: 483 GERG--APGFRGPAGPNGI----PGEKGPAGERGAPG----PAGPRGA--AGEPGRDGVP 530
Query: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA 362
+G PG P GK G SQ ++G+P S P K
Sbjct: 531 GGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPG-PSGPRGQPGVMGFPGPKG--ND 587
Query: 363 KASGKTSQVGAASAPAKESP----RKGAAPAPPGKTGPAVAKAQAGK------------- 405
A GK + G P + P + PPG TGP K G
Sbjct: 588 GAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTG 647
Query: 406 REEDSQSSSEESDSEEEAPAQAKPSGK----------------APQVRAASAPAKESPRK 449
E + +A A P GK AP +R + P K
Sbjct: 648 GPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGK 707
Query: 450 GAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVK----PLGKSPQ 505
GAA PP G A G E S D+ A V P G +
Sbjct: 708 GAA-GPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGP 766
Query: 506 VKPASTMGM-GPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAV 564
+ P G G G+G P PG GP S E G
Sbjct: 767 IGPPGPAGQPGDKGEGGAPGLPGIAGP-------------RGSPGERGETGPPGPAGFPG 813
Query: 565 APAQE-KSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEA 623
AP Q + G + P GPP AGP A P E S
Sbjct: 814 APGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPG-----G 868
Query: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR-KAGTATSPAGSSPAV 682
P A A+ P + P + S P + G P G SP S P
Sbjct: 869 PGAAGFPGARGLPGPPGSNGNPGPPGPSGS----PGKDGPPGPAGNTGAPGSPGVSGP-- 922
Query: 683 AGGTQRPAEDSS-SSEESDSEEEKTGLAVTVGQAKSVG----KGLQVKAASVPVKGSLGQ 737
G +P E S ++ G+A G G G + VKG G+
Sbjct: 923 KGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGK 982
Query: 738 GTAPVLPGKTGPTVTQ----VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKAN 793
A L G+ GP Q + E SD
Sbjct: 983 PGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSD---------------------GL 1021
Query: 794 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKA 853
P +P KG G A P V P ++ GPA P G A
Sbjct: 1022 PGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAP--GPA 1079
Query: 854 VATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPS-----GKTHQIRAALAPAKESPR 908
+ A GP D G + E + + P G Q A +P PR
Sbjct: 1080 GSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPR 1139
Query: 909 KGAAPT-PPGKTGPS 922
P+ PPGK G S
Sbjct: 1140 GPVGPSGPPGKDGTS 1154
Score = 76.6 bits (187), Expect = 1e-13
Identities = 172/759 (22%), Positives = 224/759 (29%), Gaps = 120/759 (15%)
Query: 242 PGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE-----EAPAGTRSQVKASEK 296
PG+ G P GA R P +G+ + P GT +
Sbjct: 290 PGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGA 349
Query: 297 ILQVRAASAP-AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPA 355
+V A +P + G PG+ P P G AGA Q G P + S + P
Sbjct: 350 KGEVGPAGSPGSNGAPGQRGEPGPQGHAGA---QGPPGPPGING-SPGGKGEMGPAGIPG 405
Query: 356 AKALLQAKASGKTSQVGAASAP-----AKESPRKGA--APAPPGKTGPAVAKAQAGKREE 408
A L+ A+ G GA AP A E + GA P P G+ G A G + E
Sbjct: 406 APGLMGAR--GPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGE 463
Query: 409 DSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR-KTGPAAAQVQ 467
D + S P A G AP R + P KG PA R GPA +
Sbjct: 464 DGKDGSPGEPGANGLPGAAGERG-APGFRGPAGPNGIPGEKG--PAGERGAPGPAGPRGA 520
Query: 468 VGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPG 527
G+ D M P G KP GP G PG
Sbjct: 521 AGEPGRDGVPGG----------PGMRGMPGSPGGPGSDGKP------GPPGSQGESGRPG 564
Query: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPA-- 585
GP+ P Q G + + + +GE P + G + P P
Sbjct: 565 PPGPSGPRGQPGVMGFPGPKGN-DGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPT 623
Query: 586 --------KGPPQKAGPVAVQVKAEKPMDNSESSEES-SDSADSEEAPAAMTAAQAKPAL 636
GPP G + P +N + E A + AP A A
Sbjct: 624 GPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGER 683
Query: 637 KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA-GSSPAVAGGTQRPAEDSSS 695
P P + P G A +P P GG P
Sbjct: 684 GPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDK 743
Query: 696 SEE----SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTV 751
E +D K G G G Q G G+G AP LPG GP
Sbjct: 744 GEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQ--------PGDKGEGGAPGLPGIAGPRG 795
Query: 752 TQ----------------VKAEKQEDSESSEEESDSEEAAASPAQV-------------- 781
+ + E E + E+ P V
Sbjct: 796 SPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPG 855
Query: 782 KTSVK-KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
VK + + P AA P A+G PG SP K PP
Sbjct: 856 PQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPP---------- 905
Query: 841 ARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAAL 900
GPA G A + +GP+ D+G E+ AQ P A +
Sbjct: 906 --GPA-----GNTGAPGSPGVSGPKGDAGQPGEKGSPG------AQGPPGAPGPLGIAGI 952
Query: 901 APAKESPRKGAAPTPPGKTGPSA--AQAGKQDDSGSSSE 937
A+ P P G GP ++GK +G S E
Sbjct: 953 TGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGE 991
Score = 64.7 bits (156), Expect = 4e-10
Identities = 111/511 (21%), Positives = 155/511 (30%), Gaps = 50/511 (9%)
Query: 177 GSVPAFGAAAKPGMVSAGQADS--SSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
G + G A +PG G A S E G P PA + E
Sbjct: 765 GPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPG--PAGFPGAPGQNGEPG 822
Query: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
+ APG+ G+ P G + A P + E GS A ++
Sbjct: 823 GKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPG 882
Query: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
G+PGK P P G GA S +G P+ D+ E+ S + P
Sbjct: 883 PPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSG-PKGDAGQPGEKGSPGAQGPP 941
Query: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAP-------------------APPGKTG 395
A L +G T G A P PR P PPG G
Sbjct: 942 GAPGPL--GIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQG 999
Query: 396 PAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAP 455
AG+ D S+ + +P G+ A AP P PA
Sbjct: 1000 LPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAG 1059
Query: 456 PR----KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511
++GPA G + D+ AA +K P P +
Sbjct: 1060 KSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPG-NPGAP 1118
Query: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS--------------SEESSDSSD 557
GP G+ PG GP P G +D S E S+ S
Sbjct: 1119 GSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSP 1178
Query: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
G P + G ++ A +KAG A ++PMD +++E S
Sbjct: 1179 GHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFA-PYYGDEPMDFKINTDEIMTS 1237
Query: 618 ADSE----EAPAAMTAAQAKPALKIPQTKAC 644
S E+ + ++ PA K C
Sbjct: 1238 LKSVNGQIESLISPDGSRKNPARNCRDLKFC 1268
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/651 (21%), Positives = 185/651 (28%), Gaps = 98/651 (15%)
Query: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
G PG P PPG G G P + A+ + +GK
Sbjct: 171 GYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKD 230
Query: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
+ G P + P PPG GPA G + E AP
Sbjct: 231 GESGRPGRPGER-----GLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKG 285
Query: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREA 488
+G P + AP P GP A + G+ + + +D R
Sbjct: 286 ENG--------------LPGENGAPGP---MGPRGAPGERGRPGLPGAAGARGNDGAR-- 326
Query: 489 LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548
G Q P G G P G+VGPA G + E
Sbjct: 327 ------------GSDGQPGPPGPPGTA--GFPGSPGAKGEVGPAGSPGSNGAPGQRGEPG 372
Query: 549 SEESSDSSDGEVPTAV--APAQEKSLGNI-LQAKPTSSPAKGPPQKAGPVAVQVKAEKPM 605
+ + + P + +P + +G + P A+GPP AG P
Sbjct: 373 PQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGA------PG 426
Query: 606 DNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTA--SAKVAPVRVGT 663
+ E + A E P P +P K K + A P G
Sbjct: 427 LRGGAGEPGKNGAKGEPGPRGERGEAGIPG--VPGAKGEDGKDGSPGEPGANGLPGAAGE 484
Query: 664 Q-AP---RKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVG 719
+ AP AG P PA G PA ++ E + G + G
Sbjct: 485 RGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGG 544
Query: 720 KGLQVKAASVPVKGSLGQGTAPVLPGKTGPT----VTQVKAEKQEDSESSEEESDSEEAA 775
G K GS G+ P PG +GP V K D +
Sbjct: 545 PGSDGKPGP---PGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGG 601
Query: 776 ASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQ 835
P +T + P KG PG Q Q P PP N +
Sbjct: 602 PGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPG------PQGLQGLPGTGGPPGENGK 655
Query: 836 NSTVLARGPASVPSV--GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
+G A P GK A A + GP +G+
Sbjct: 656 PGEPGPKGDAGAPGAPGGKGDA-GAPGERGPPGLAGAP---------------------- 692
Query: 894 HQIRAALAPAKESPRKGAA--PTPPGKTGPSAAQA--GKQDDSGSSSEESD 940
+R P KGAA P PPG G Q G++ GS + D
Sbjct: 693 -GLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGD 742
Score = 57.0 bits (136), Expect = 8e-08
Identities = 131/645 (20%), Positives = 196/645 (30%), Gaps = 93/645 (14%)
Query: 309 GTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKT 368
G PG+ P PG+ G+ S G E S + ++ + ++ K+ G
Sbjct: 115 GIPGRNGDPGIPGQPGSPGSPGPPGICE--SCPTGPQNYSPQYDSYDVKS--GVAVGGLA 170
Query: 369 SQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAK 428
G A P P PPG +G + G + + P
Sbjct: 171 GYPGPAGPP--------GPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIG 222
Query: 429 PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAA---QVQVGKQEEDSRSSSEESDSD 485
PSG A + + P + P + P PP GPA G + D R + E+ ++
Sbjct: 223 PSGPAGKDGESGRPGR--PGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGR-NGEKGETG 279
Query: 486 REALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS 545
L N P GP+G P G+ P P A + + +
Sbjct: 280 APGLKGENGL------------PGENGAPGPMGPRGAPGERGR--PGLPGAAGARGNDGA 325
Query: 546 ESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP-AKGPPQKAGPVAVQVKAEKP 604
S + G TA P + G + P SP + G P + G Q A
Sbjct: 326 RGS--DGQPGPPGPPGTAGFPGSPGAKGEV---GPAGSPGSNGAPGQRGEPGPQGHAGAQ 380
Query: 605 MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQ 664
S E PA + AP +G +
Sbjct: 381 GPPGPPGINGSPGGKGEMGPAGIPG---------------------------APGLMGAR 413
Query: 665 APRKAGTATSPAGS--SPAVAGGTQRPAEDSSSSEESD-SEEEKTGLAVTVGQAKSVGK- 720
P PAG+ +P + GG P ++ + E E + G+ G GK
Sbjct: 414 GP------PGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKD 467
Query: 721 GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780
G + + + G+ G+ AP G GP + EK E A P
Sbjct: 468 GSPGEPGANGLPGAAGERGAPGFRGPAGP--NGIPGEKGPAGER------GAPGPAGPRG 519
Query: 781 VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVL 840
+ P P + G + GK +Q + P P Q +
Sbjct: 520 AAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMG 579
Query: 841 ARGP-ASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAET-----LAQVKPSGK-- 892
GP + + GK GP+ G + E T P G
Sbjct: 580 FPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQG 639
Query: 893 THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSE 937
+ P E+ + G P P G G A GK D+G+ E
Sbjct: 640 LQGLPGTGGPPGENGKPG-EPGPKGDAGAPGAPGGK-GDAGAPGE 682
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.295 0.113 0.295
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,228,137
Number of Sequences: 37866
Number of extensions: 2437457
Number of successful extensions: 40691
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 466
Number of HSP's successfully gapped in prelim test: 2412
Number of HSP's that attempted gapping in prelim test: 15381
Number of HSP's gapped (non-prelim): 15499
length of query: 958
length of database: 18,247,518
effective HSP length: 112
effective length of query: 846
effective length of database: 14,006,526
effective search space: 11849520996
effective search space used: 11849520996
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.