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Search of human proteins with 134142342
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|134142342 ATP-binding cassette, sub-family C, member 1
isoform 4 [Homo sapiens]
(1416 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 2802 0.0
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 2694 0.0
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 2610 0.0
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 1416 0.0
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 1416 0.0
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 811 0.0
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 717 0.0
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 637 0.0
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 635 0.0
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 589 e-168
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 494 e-139
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 474 e-133
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 458 e-128
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 457 e-128
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 446 e-125
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 446 e-125
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 429 e-119
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 404 e-112
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 404 e-112
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 398 e-110
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 347 6e-95
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 276 1e-73
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 240 6e-63
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 177 6e-44
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 168 4e-41
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 164 4e-40
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 162 3e-39
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 162 3e-39
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 155 2e-37
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 154 6e-37
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 2802 bits (7263), Expect = 0.0
Identities = 1416/1416 (100%), Positives = 1416/1416 (100%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
Query: 721 DVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ 780
DVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ
Sbjct: 721 DVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQ 780
Query: 781 MENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT 840
MENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT
Sbjct: 781 MENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT 840
Query: 841 GQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 900
GQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR
Sbjct: 841 GQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVR 900
Query: 901 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 960
LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR
Sbjct: 901 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 960
Query: 961 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1020
FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA
Sbjct: 961 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1020
Query: 1021 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1080
SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA
Sbjct: 1021 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1080
Query: 1081 NRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEME 1140
NRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEME
Sbjct: 1081 NRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEME 1140
Query: 1141 TNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINV 1200
TNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINV
Sbjct: 1141 TNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINV 1200
Query: 1201 TINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQ 1260
TINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQ
Sbjct: 1201 TINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQ 1260
Query: 1261 DPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQR 1320
DPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQR
Sbjct: 1261 DPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQR 1320
Query: 1321 QLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYT 1380
QLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYT
Sbjct: 1321 QLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYT 1380
Query: 1381 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1381 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 2694 bits (6982), Expect = 0.0
Identities = 1380/1478 (93%), Positives = 1393/1478 (94%), Gaps = 65/1478 (4%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRIL----------- 709
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK +
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND 720
Query: 710 -------------------VTHSMSYLPQVDVIIVMSGGKISEMGSYQELL--------- 741
V + + LP ++ ++ G +E+G +L
Sbjct: 721 SLRENILFGCQLEEPYYRSVIQACALLPDLE---ILPSGDRTEIGEKTRILVTHSMSYLP 777
Query: 742 -------------ARDGAFAEFL----------RTYASTEQEQDAEENGVTGVSGPGKEA 778
+ G++ E L RTYASTEQEQDAEENGVTGVSGPGKEA
Sbjct: 778 QVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEA 837
Query: 779 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 838
KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA
Sbjct: 838 KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKA 897
Query: 839 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 898
QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK
Sbjct: 898 QTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTK 957
Query: 899 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 958
VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV
Sbjct: 958 VRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLV 1017
Query: 959 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1018
NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY
Sbjct: 1018 NRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFY 1077
Query: 1019 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1078
VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI
Sbjct: 1078 VASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSI 1137
Query: 1079 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1138
VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE
Sbjct: 1138 VANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSE 1197
Query: 1139 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1198
METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI
Sbjct: 1198 METNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHI 1257
Query: 1199 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1258
NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII
Sbjct: 1258 NVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITII 1317
Query: 1259 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1318
PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG
Sbjct: 1318 PQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVG 1377
Query: 1319 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1378
QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD
Sbjct: 1378 QRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMD 1437
Query: 1379 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1438 YTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1475
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 2610 bits (6764), Expect = 0.0
Identities = 1343/1472 (91%), Positives = 1360/1472 (92%), Gaps = 56/1472 (3%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK--------------T 706
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLA 720
Query: 707 RILVTHSMSY-----LPQVDVII--------------------VMSGGKISEMGSYQELL 741
R + +++ Y L VD + ++ +S + ++
Sbjct: 721 RAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 780
Query: 742 ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK-------- 793
G + +Y A + + +E ENG+ GK
Sbjct: 781 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 840
Query: 794 ---------QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 844
QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 841 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 900
Query: 845 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 904
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 901 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 960
Query: 905 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 964
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 961 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1020
Query: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1024
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 1021 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1080
Query: 1025 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1084
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1081 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1140
Query: 1085 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1144
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1141 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1200
Query: 1145 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1204
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1201 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1260
Query: 1205 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1264
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1261 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1320
Query: 1265 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1324
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC
Sbjct: 1321 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1380
Query: 1325 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1384
LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV
Sbjct: 1381 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1440
Query: 1385 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1441 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1472
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 1416 bits (3665), Expect = 0.0
Identities = 709/719 (98%), Positives = 712/719 (99%), Gaps = 6/719 (0%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK S++Y+PQ
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK------GSVAYVPQ 713
Score = 1205 bits (3118), Expect = 0.0
Identities = 632/713 (88%), Positives = 648/713 (90%), Gaps = 19/713 (2%)
Query: 605 SIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGI 664
S++QA L L I S + E E+ GG +++ A ++ A +
Sbjct: 739 SVIQACALLPDLEILPSGDRTEIG--EKGVNLSGGQKQRVSLARAVYSNA-------DIY 789
Query: 665 TFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVII 724
F P A+ A VG+ + + +G + KTRILVTHSMSYLPQVDVII
Sbjct: 790 LFDDPLSAVDAHVGK----------HIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
Query: 725 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 784
VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG
Sbjct: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
Query: 785 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 844
MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
Query: 845 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 904
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 960 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 1019
Query: 905 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 964
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 1020 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
Query: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1024
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1139
Query: 1025 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1084
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1140 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1199
Query: 1085 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1144
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1200 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1259
Query: 1145 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1204
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1260 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1319
Query: 1205 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1264
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1320 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1379
Query: 1265 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSV 1317
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL V
Sbjct: 1380 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLRV 1432
Score = 95.9 bits (237), Expect = 2e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 1041 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1094
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
Query: 1095 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1154
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
Query: 1155 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1214
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
Query: 1215 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1274
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
Query: 1275 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 1335 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1391
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 1392 EYGAPSDLLQQRGLF 1406
E G+ +LL + G F
Sbjct: 848 EMGSYQELLARDGAF 862
Score = 73.6 bits (179), Expect = 1e-12
Identities = 36/36 (100%), Positives = 36/36 (100%)
Query: 1381 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1431 RVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1466
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 1416 bits (3665), Expect = 0.0
Identities = 709/719 (98%), Positives = 712/719 (99%), Gaps = 6/719 (0%)
Query: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
Sbjct: 1 MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH 60
Query: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
Sbjct: 61 DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA 120
Query: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
Sbjct: 121 TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS 180
Query: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
Sbjct: 181 LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD 240
Query: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
Sbjct: 241 LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL 300
Query: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
Sbjct: 301 IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD 360
Query: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
Sbjct: 361 WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV 420
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN 480
Query: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
Sbjct: 481 AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK 540
Query: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
Sbjct: 541 KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
Query: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
Sbjct: 601 MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT 660
Query: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK S++Y+PQ
Sbjct: 661 LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK------GSVAYVPQ 713
Score = 1396 bits (3613), Expect = 0.0
Identities = 732/812 (90%), Positives = 748/812 (92%), Gaps = 19/812 (2%)
Query: 605 SIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGI 664
S++QA L L I S + E E+ GG +++ A ++ A +
Sbjct: 739 SVIQACALLPDLEILPSGDRTEIG--EKGVNLSGGQKQRVSLARAVYSNA-------DIY 789
Query: 665 TFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQVDVII 724
F P A+ A VG+ + + +G + KTRILVTHSMSYLPQVDVII
Sbjct: 790 LFDDPLSAVDAHVGK----------HIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVII 839
Query: 725 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 784
VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG
Sbjct: 840 VMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENG 899
Query: 785 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 844
MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK
Sbjct: 900 MLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVK 959
Query: 845 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 904
LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY
Sbjct: 960 LSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVY 1019
Query: 905 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 964
GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE
Sbjct: 1020 GALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
Query: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1024
LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ
Sbjct: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQ 1139
Query: 1025 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1084
LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL
Sbjct: 1140 LKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL 1199
Query: 1085 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1144
AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV
Sbjct: 1200 AVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIV 1259
Query: 1145 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1204
AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING
Sbjct: 1260 AVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTING 1319
Query: 1205 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1264
GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL
Sbjct: 1320 GEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVL 1379
Query: 1265 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1324
FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC
Sbjct: 1380 FSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVC 1439
Query: 1325 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1384
LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV
Sbjct: 1440 LARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIV 1499
Query: 1385 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Sbjct: 1500 LDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1531
Score = 95.9 bits (237), Expect = 2e-19
Identities = 96/375 (25%), Positives = 159/375 (42%), Gaps = 27/375 (7%)
Query: 1041 NETLLGVSVIR------AFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNC 1094
NE L G+ V++ AF+++ I Q +LKV + + AY ++ W+ V C
Sbjct: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK-KSAYLSAVGTFTWVCTPF-LVALC 563
Query: 1095 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1154
FA + + L A +S++ + LN L + S + V+++RL+ +
Sbjct: 564 T--FAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLS 621
Query: 1155 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1214
E+ P I E P + RN + L I +I G V +VG+
Sbjct: 622 HEELEPDSI-ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQV 680
Query: 1215 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1274
G GKSSL L + EG + I G + +PQ + + SLR N+
Sbjct: 681 GCGKSSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENIL 727
Query: 1275 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
Q + + ++ L + LP E E G NLS GQ+Q V LARA+
Sbjct: 728 FGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNAD 787
Query: 1335 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1391
I + D+ +AVD I + + ++ T + + H ++ + +IV+ G+I
Sbjct: 788 IYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKIS 847
Query: 1392 EYGAPSDLLQQRGLF 1406
E G+ +LL + G F
Sbjct: 848 EMGSYQELLARDGAF 862
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 811 bits (2095), Expect = 0.0
Identities = 418/732 (57%), Positives = 539/732 (73%), Gaps = 17/732 (2%)
Query: 699 EGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTE 758
EG +A KTR+LVTH +S+LPQ D IIV++ G++SEMG Y LL R+G+FA FL YA E
Sbjct: 797 EGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDE 856
Query: 759 QEQDAEENGVTGVSGPGKEAKQMENGML----------VTDSAGKQLQRQLSSSSS---- 804
+ E++ KEA +E+ + VT KQ RQLS+ SS
Sbjct: 857 DQGHLEDSWTALEGAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEG 916
Query: 805 YSGDISRHHNSTAE-LQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLS 863
+ R H +E +Q EAK + L + +KA G V+LSV+WDY KA+GL +
Sbjct: 917 QGRPVPRRHLGPSEKVQVTEAKADGA--LTQEEKAAIGTVELSVFWDYAKAVGLCTTLAI 974
Query: 864 IFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVS 923
L++ +A+ +N WLS WT+D + + Q +T +RL VY ALGI QG V +MA++
Sbjct: 975 CLLYVGQSAAAIGANVWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMA 1034
Query: 924 IGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSL 983
GGI A+R LH LLH+ +RSP SFF+ TPSG ++N FSK++ VD ++ VI M + S
Sbjct: 1035 AGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSF 1094
Query: 984 FNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNET 1043
FN I +VI+ +TP+ ++I PL ++Y VQRFY A+SRQLKRLESVSRSP+YSHF+ET
Sbjct: 1095 FNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSET 1154
Query: 1044 LLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA 1103
+ G SVIRA+ F SD KVD NQ++ YP I++NRWL++ +E VGNC+VLFAALFA
Sbjct: 1155 VTGASVIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFA 1214
Query: 1104 VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
VI R SL+ GLVGLSVSYSLQVT LNW++RM S++E+NIVAVER+KEYS+TE EAPW +
Sbjct: 1215 VIGRSSLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVV 1274
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
+ + PP WP G VEFRNY +RYR LD VLR +++ ++GGEKVGIVGRTGAGKSS+TL
Sbjct: 1275 EGSRPPEGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTL 1334
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
LFRI E+A+GEI IDG+N+A IGLHDLR ++TIIPQDP+LFSG+LRMNLDPF YS+E+
Sbjct: 1335 CLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEED 1394
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
+W +LEL+HL FVS+ P LD +C+EGGENLSVGQRQLVCLARALLRK++ILVLDEATA
Sbjct: 1395 IWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATA 1454
Query: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
A+DLETD+LIQ+TIRTQF+ CTVLTIAHRLNTIMDYTRV+VLDKG + E+ +P++L+ R
Sbjct: 1455 AIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAAR 1514
Query: 1404 GLFYSMAKDAGL 1415
G+FY MA+DAGL
Sbjct: 1515 GIFYGMARDAGL 1526
Score = 758 bits (1956), Expect = 0.0
Identities = 380/712 (53%), Positives = 505/712 (70%), Gaps = 22/712 (3%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIV 607
TFTW+C+PFLV L T VYV +D NN+LDA+ AFVS++LFNILR PLN+LP +IS++
Sbjct: 534 TTTFTWMCSPFLVTLITLWVYVYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLT 593
Query: 608 QASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFS 667
QASVSLKR++ FLS EEL+P S+ER+ + G +IT+ + TFTWA+ PPTL+ +
Sbjct: 594 QASVSLKRIQQFLSQEELDPQSVERKTISPG---YAITIHSGTFTWAQDLPPTLHSLDIQ 650
Query: 668 IPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
+P+GALVAVVG VGCGKSSL+SALL EM+K+EG V +K S++Y+PQ
Sbjct: 651 VPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMK------GSVAYVPQ 696
Score = 86.7 bits (213), Expect = 1e-16
Identities = 98/422 (23%), Positives = 178/422 (42%), Gaps = 36/422 (8%)
Query: 993 ILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRA 1052
+L ++IP G + ++ F V +Q+K +S + +E L G+ V++
Sbjct: 452 VLAGVAFMVLLIPLNGAVAVKMRAFQV---KQMKLKDSRIKL-----MSEILNGIKVLKL 503
Query: 1053 FEEQERFIHQSD-LKVDENQ----KAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
+ + F+ Q + ++ E Q AY + W+ + I L+ ++ V
Sbjct: 504 YAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPF--LVTLITLWVYVY-VDPN 560
Query: 1108 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1167
+ L A +SVS + LN L ++ S + V+++R++++ E+ P ++
Sbjct: 561 NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKT 620
Query: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
+ + + + +DL L +++ + G V +VG G GKSSL L
Sbjct: 621 ISPGYA----ITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
Query: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
E EG++ + G + +PQ + + +L+ N+ + + +
Sbjct: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
Query: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
LE L + LP E E G NLS GQRQ V LARA+ I +LD+ +AVD
Sbjct: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
Query: 1348 ETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1404
I + T + + H ++ + +IVL G++ E G LLQ+ G
Sbjct: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
Query: 1405 LF 1406
F
Sbjct: 844 SF 845
Score = 45.4 bits (106), Expect = 4e-04
Identities = 63/290 (21%), Positives = 116/290 (40%), Gaps = 12/290 (4%)
Query: 421 GEIVNLMSVDAQRFMD-LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPV 479
G I+N S D + LA I M+ ++ I L ++ + + + + VL V
Sbjct: 1066 GRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLV 1125
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYA----WELAFKDKVLAIRQEE 535
A ++ + S+ +E + G V++ Y +E+ KV A ++
Sbjct: 1126 QRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRSC 1185
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFP 595
+ + +LS F C AL FAV N L + SL + F
Sbjct: 1186 YPYIISNRWLSIGVEFVGNCVVLFAAL--FAVIGRSSLNPGLVGLSVSYSLQV----TFA 1239
Query: 596 LNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE-RRPVKDGGGTNSITVRNATFTWA 654
LN + ++S + V+++R++ + E P +E RP + + RN + +
Sbjct: 1240 LNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYR 1299
Query: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
L ++ + G V +VG+ G GKSS+ L ++ +G + I
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRI 1349
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 717 bits (1850), Expect = 0.0
Identities = 381/728 (52%), Positives = 510/728 (70%), Gaps = 20/728 (2%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS-TEQEQDA 763
KTR+LVTHSM +LPQVD I+V+ G I E GSY LLA+ G FA+ L+T+ T E++A
Sbjct: 813 KTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEA 872
Query: 764 -------EENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNST 816
EE+ G+ +E E+ +T +R LS SS +G + ++
Sbjct: 873 TVHDGSEEEDDDYGLISSVEEIP--EDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNS 930
Query: 817 AELQKAEAKKEET-----WKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNH 871
+ + + KE+ KL++ + +TG+VK S+Y +Y++AIGLF F I F+ N
Sbjct: 931 LKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNS 990
Query: 872 VSALASNYWLSLWTDDP-IVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGI 927
V+ + SN WLS WT D I N T +R+ VYGALG++QGI VF + G +
Sbjct: 991 VAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFV 1050
Query: 928 LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI 987
AS LH LL++ILR+PM FF+ TP+G +VNRF+ ++ TVD +P+ ++ ++ +I
Sbjct: 1051 HASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGII 1110
Query: 988 GACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1047
++I +ATP+ II+ PLG+IY VQ FYV++SRQL+RL+SV+RSP+YSHF+ET+ G+
Sbjct: 1111 STLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGL 1170
Query: 1048 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
VIRAFE Q+RF+ +++++D NQK + I +NRWLA+RLE VGN V F+AL VI R
Sbjct: 1171 PVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYR 1230
Query: 1108 HSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETA 1167
+LS VG +S +L +T LNWLVRM+SE+ETNIVAVER+ EY++ E EAPW + +
Sbjct: 1231 DTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPW-VTDKR 1289
Query: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
PP WP G+++F NY +RYR +LD VLR I I EK+G+VGRTGAGKSSLT LFR
Sbjct: 1290 PPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFR 1349
Query: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
I E+A G+IIIDG++IA IGLHDLR K+TIIPQDP+LFSGSLRMNLDPF+ YSDEE+W +
Sbjct: 1350 ILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKA 1409
Query: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
LELAHLK FV++L L HE E G NLS+GQRQL+CL RALLRK+KILVLDEATAAVDL
Sbjct: 1410 LELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDL 1469
Query: 1348 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFY 1407
ETD+LIQ+TI+ +F CTV+TIAHRL+TIMD +V+VLD G+I E G+P +LLQ G FY
Sbjct: 1470 ETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFY 1529
Query: 1408 SMAKDAGL 1415
MAK+AG+
Sbjct: 1530 FMAKEAGI 1537
Score = 486 bits (1251), Expect = e-137
Identities = 280/717 (39%), Positives = 427/717 (59%), Gaps = 40/717 (5%)
Query: 22 WNTS-----NPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKTA 76
WN+S D CF+ TVLVW+P +LW P+ L++ + T L K
Sbjct: 11 WNSSFLDSPEADLPLCFEQTVLVWIPLGFLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQV 70
Query: 77 -LGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
+GFLL I+ +L E S + V +P+L T LL LIQ R+ VQ +
Sbjct: 71 FVGFLL-ILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLV-LLIQYSRQWCVQKN 128
Query: 136 GIMLT-FWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDR 194
L+ FW+++++C ++ I T L+ D +L F++ + ++ L+ S FS+
Sbjct: 129 SWFLSLFWILSILCGTFQFQTLIRTLLQGDNS-NLAYSCLFFISYGFQILILIFSAFSEN 187
Query: 195 SPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVV 254
+ + + P S ASFLS IT+ W +I++GY++PL D+W +++E ++ +V
Sbjct: 188 N--------ESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLV 239
Query: 255 PVLVKNWKKECAKTRK--QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPS 312
+ K+E K R+ Q + S ++ + ++ +AL+++ +K+ S
Sbjct: 240 SKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKS 299
Query: 313 ----------LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQ 362
L K L+KTF L SF K ++D+ F PQ+LKLLI F +D W
Sbjct: 300 GTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWI 359
Query: 363 GYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGE 422
GY +LLF A +Q+ L YF +CF G++++TA++ +VY+KAL ++N ARK TVGE
Sbjct: 360 GYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGE 419
Query: 423 IVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
VNLMSVDAQ+ MD+ +++M+WS+ LQ++L+++ LW LGPSVLAGV VMVL++P+NA+
Sbjct: 420 TVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAI 479
Query: 483 MAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++ K+KT QV +MK+KD R+K+MNEIL+GIK+LK +AWE +F+D+V +R++ELK L
Sbjct: 480 LSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAF 539
Query: 543 AYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMV 602
+ L V F + TP LV++ TF+VYV +D NNILDAQ AF S+ LFNILRFPL++LPM+
Sbjct: 540 SQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMM 599
Query: 603 ISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLN 662
ISS++QASVS +RL +L ++L+ +I D ++ A+FTW T+
Sbjct: 600 ISSMLQASVSTERLEKYLGGDDLDTSAIRH----DCNFDKAMQFSEASFTWEHDSEATVR 655
Query: 663 GITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
+ I G LVAV+G VG GKSSL+SA+L EM+ V GH+ IK + +Y+PQ
Sbjct: 656 DVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIK------GTTAYVPQ 706
Score = 92.4 bits (228), Expect = 3e-18
Identities = 94/375 (25%), Positives = 159/375 (42%), Gaps = 31/375 (8%)
Query: 1041 NETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWL------AVRLECVGNC 1094
NE L G+ +++ F + F Q V +K +++A L +L V
Sbjct: 503 NEILSGIKILKYFAWEPSFRDQ----VQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVS 558
Query: 1095 IVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSE 1154
+V F+ V S + L A S++ + L+ L M S M V+ ERL++Y
Sbjct: 559 VVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLG 618
Query: 1155 TEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRT 1214
+ I+ Q F + D + +R +N+ I G+ V ++G
Sbjct: 619 GDDLDTSAIRHDCNFDKAMQFSEASFT-----WEHDSEATVRDVNLDIMAGQLVAVIGPV 673
Query: 1215 GAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD 1274
G+GKSSL + E+ G I I G +PQ + +G+++ N+
Sbjct: 674 GSGKSSLISAMLGEMENVHGHITIKGTT-------------AYVPQQSWIQNGTIKDNIL 720
Query: 1275 PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
++++++ LE L + LP E E G NLS GQ+Q + LARA +
Sbjct: 721 FGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLD 780
Query: 1335 ILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQ 1391
I +LD+ +AVD I + + + T L + H ++ + ++VL G I
Sbjct: 781 IYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIV 840
Query: 1392 EYGAPSDLLQQRGLF 1406
E G+ S LL ++G F
Sbjct: 841 EKGSYSALLAKKGEF 855
Score = 46.6 bits (109), Expect = 2e-04
Identities = 60/294 (20%), Positives = 115/294 (39%), Gaps = 13/294 (4%)
Query: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIW-SAPLQVILALYLLWLNLGPSVLAGVAVMVL 475
++ G IVN + D D W + L +I L ++ + + + + ++
Sbjct: 1074 TTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGII 1133
Query: 476 MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
V V ++ + ++ +E ++G+ V++ AF+ + ++ E
Sbjct: 1134 YVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIR------AFEHQQRFLKHNE 1187
Query: 536 LKV-LKKSAYLSAVGTFTWVCTPF-LVALCTF---AVYVTIDENNILDAQTAFVSLALFN 590
+++ + S + + W+ LV T A+ + I + + FV N
Sbjct: 1188 VRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALN 1247
Query: 591 ILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNAT 650
I + LN L + S I V+++R+ + E P ++RP D I N
Sbjct: 1248 ITQ-TLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQ 1306
Query: 651 FTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+ L GIT I + VVG+ G GKSSL + L ++ G + I
Sbjct: 1307 VRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIII 1360
Score = 32.7 bits (73), Expect = 2.5
Identities = 17/50 (34%), Positives = 26/50 (52%)
Query: 698 VEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF 747
++ A T I + H + + D ++V+ GKI E GS +ELL G F
Sbjct: 1479 IQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPF 1528
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 637 bits (1642), Expect = 0.0
Identities = 345/716 (48%), Positives = 477/716 (66%), Gaps = 23/716 (3%)
Query: 706 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
TRILVTH++ LPQ D IIV++ G I+EMGSYQELL R GA L +Q + +
Sbjct: 806 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL------DQARQPGD 859
Query: 766 NGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQLSSSSSYSGDISRHHNSTAELQKA- 822
G G + PG K SAG+ +L+R+ S S + +T+E Q
Sbjct: 860 RG-EGETEPGTSTKDPRG-----TSAGRRPELRRERSIKS-----VPEKDRTTSEAQTEV 908
Query: 823 --EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 880
+ W + D Q G+VK +V+ Y++A+G + ++FLF+C V++ YW
Sbjct: 909 PLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYW 967
Query: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
LSLW DDP V G Q +R ++G LG Q I +F AV +GG ASR L LL
Sbjct: 968 LSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 1027
Query: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
++RSP+SFFERTP G+L+NRFSKE DTVD IP+ ++ + F ++ +V+ +ATP+A
Sbjct: 1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLA 1087
Query: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
+ I PL L+Y Q YV SS QL+RLES S S V SH ET G +V+RAF Q F+
Sbjct: 1088 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 1147
Query: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V AA AV+S+ LSAGLVG SVS
Sbjct: 1148 AQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS 1207
Query: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEF 1180
+LQVT L W+VR +++E +IV+VER+++Y+ T KEAPW++ A WPQ G++EF
Sbjct: 1208 AALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF 1267
Query: 1181 RNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1240
R++ LRYR +L ++ ++ I+ GEKVGIVGRTGAGKSSL GL R+ E+AEG I IDG
Sbjct: 1268 RDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDG 1327
Query: 1241 INIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSAL 1300
+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD ++SDE +W +LE LK V++L
Sbjct: 1328 VPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASL 1387
Query: 1301 PDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQ 1360
P +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL+LDEATAAVD T+ +Q+ + +
Sbjct: 1388 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1447
Query: 1361 FEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
F CTVL IAHRL ++MD RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1448 FAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
Score = 518 bits (1335), Expect = e-146
Identities = 276/704 (39%), Positives = 413/704 (58%), Gaps = 25/704 (3%)
Query: 22 WNTSNPD------FTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQMTPLNKTKT 75
WN + P+ + CF T VWVP YLW P Y L++ H RGY++M+PL K K
Sbjct: 14 WNQTEPEPAATSLLSLCFLRTAGVWVPPMYLWVLGPIYLLFIHHHGRGYLRMSPLFKAKM 73
Query: 76 ALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLERRKGVQSS 135
LGF L ++C + + + W+ +G AP FL+ PT+ TM A FLI ER+KGVQSS
Sbjct: 74 VLGFALIVLCTSSVAVALWKIQQGTPEAPEFLIHPTVWLTTMSFAVFLIHTERKKGVQSS 133
Query: 136 GIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRS 195
G++ +WL+ C + + A Q D R ++ Y+ SL++ Q VLSC +D+
Sbjct: 134 GVLFGYWLL---CFVLPATNAAQQASGAGFQSDPVRHLSTYLCLSLVVAQFVLSCLADQP 190
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P F E NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 191 PFFPEDPQQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVS 250
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 251 RLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLK 301
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTAC 375
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++AC
Sbjct: 302 AIWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSAC 361
Query: 376 LQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFM 435
LQTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR
Sbjct: 362 LQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLT 421
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+ Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M
Sbjct: 422 ESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQM 481
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
+ KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++
Sbjct: 482 RQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQV 541
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
+ FLVAL FAV+ + E N ++A+ AFV+L + NIL LP I S+VQA VS R
Sbjct: 542 STFLVALVVFAVHTLVAE-NAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDR 600
Query: 616 LRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVA 675
L FL EE++P ++ G + IT+ +ATF W++ PP L+ I ++P+G L+A
Sbjct: 601 LVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLTVPQGCLLA 660
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
VVG VG GKSSLLSALL E+ KVEG V+I+ +++Y+PQ
Sbjct: 661 VVGPVGAGKSSLLSALLGELSKVEGFVSIE------GAVAYVPQ 698
Score = 82.0 bits (201), Expect = 4e-15
Identities = 62/222 (27%), Positives = 102/222 (45%), Gaps = 16/222 (7%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
L IN+T+ G + +VG GAGKSSL L EG + I+G
Sbjct: 646 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------------- 692
Query: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
+ +PQ+ + + S+ N+ + + LE L+ V + P+ + E G N
Sbjct: 693 VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMN 752
Query: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAH 1371
LS GQ+Q + LARA+ RK + +LD+ AA+D + + + + T + + H
Sbjct: 753 LSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTH 812
Query: 1372 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDA 1413
L+ + +IVL G I E G+ +LLQ++G + A
Sbjct: 813 ALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQA 854
Score = 40.8 bits (94), Expect = 0.009
Identities = 26/78 (33%), Positives = 36/78 (46%), Gaps = 3/78 (3%)
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
P + P GG I R+ + P + G++F I G V +VG+ G GKSS
Sbjct: 1251 PTCAAQPPWPQGG---QIEFRDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSS 1307
Query: 687 LLSALLAEMDKVEGHVAI 704
L S LL + EG + I
Sbjct: 1308 LASGLLRLQEAAEGGIWI 1325
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 635 bits (1638), Expect = 0.0
Identities = 344/716 (48%), Positives = 477/716 (66%), Gaps = 23/716 (3%)
Query: 706 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
TRILVTH++ LPQ D IIV++ G I+EMGSYQELL R GA L +Q + +
Sbjct: 615 TRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLL------DQARQPGD 668
Query: 766 NGVTGVSGPGKEAKQMENGMLVTDSAGK--QLQRQLSSSSSYSGDISRHHNSTAELQKA- 822
G G + PG K SAG+ +L+R+ S S + +T+E Q
Sbjct: 669 RG-EGETEPGTSTKDPRG-----TSAGRRPELRRERSIKS-----VPEKDRTTSEAQTEV 717
Query: 823 --EAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYW 880
+ W + D Q G+VK +V+ Y++A+G + ++FLF+C V++ YW
Sbjct: 718 PLDDPDRAGWPAGK-DSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYW 776
Query: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
LSLW DDP V G Q +R ++G LG Q I +F AV +GG ASR L LL
Sbjct: 777 LSLWADDPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 836
Query: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
++RSP+SFFERTP G+L+NRFSKE DTVD IP+ ++ + F ++ +V+ +ATP+A
Sbjct: 837 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLA 896
Query: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
+ I PL L+Y Q YV SS QL+RLES S S V SH ET G +V+RAF Q F+
Sbjct: 897 TVAILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFV 956
Query: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
Q++ +VDE+Q+ +P +VA+RWLA +E +GN +V AA AV+S+ LSAGLVG SVS
Sbjct: 957 AQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVS 1016
Query: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEF 1180
+LQVT L W+VR +++E +IV+VER+++Y+ T KEAPW++ A WPQ G++EF
Sbjct: 1017 AALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPPWPQGGQIEF 1076
Query: 1181 RNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDG 1240
+++ LRYR +L ++ ++ I+ GEKVGIVGRTGAGKSSL GL R+ E+AEG I IDG
Sbjct: 1077 QDFGLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDG 1136
Query: 1241 INIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSAL 1300
+ IA +GLH LR +I+IIPQDP+LF GSLRMNLD ++SDE +W +LE LK V++L
Sbjct: 1137 VPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASL 1196
Query: 1301 PDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQ 1360
P +L ++CA+ GE+LSVGQ+QL+CLARALLRKT+IL+LDEATAAVD T+ +Q+ + +
Sbjct: 1197 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1256
Query: 1361 FEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV 1416
F CTVL IAHRL ++MD RV+V+DKG++ E G+P+ LL Q+GLFY +A+++GLV
Sbjct: 1257 FAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
Score = 388 bits (997), Expect = e-107
Identities = 205/523 (39%), Positives = 316/523 (60%), Gaps = 16/523 (3%)
Query: 197 LFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPV 256
+F+ + NPCPE+ A+F S+ TFWW++GL+ RGYR+PL DLWSL +E++SE++V
Sbjct: 1 MFTFSTKYTNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSR 60
Query: 257 LVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKV 316
L K W + + R+ + + K + K E E + + +W P L K
Sbjct: 61 LEKEWMRNRSAARRHNKAIAFKRKGGSGMKAP-------ETEPFL-RQEGSQWRP-LLKA 111
Query: 317 LYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACL 376
+++ F FL+ I D+ F+ P++L L ++F+ D K P W+GY VL+F++ACL
Sbjct: 112 IWQVFHSTFLLGTLSLIISDVFRFTVPKLLSLFLEFIGDPKPPAWKGYLLAVLMFLSACL 171
Query: 377 QTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD 436
QTL Q + V MR+++A+ G VYRK L +++ +RK+S VG++VNL+SVD QR +
Sbjct: 172 QTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTE 231
Query: 437 LATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMK 496
Y+N +W + +++ LW LGPS L +AV + ++P+N ++ K +Q M+
Sbjct: 232 SVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMR 291
Query: 497 SKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCT 556
KD+R +L + IL K +K + WE AF D+VL IR +EL L+ S L +V ++ +
Sbjct: 292 QKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVS 351
Query: 557 PFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRL 616
FLVAL FAV+ + EN ++A+ AFV+L + NIL LP I S+VQA VS RL
Sbjct: 352 TFLVALVVFAVHTLVAEN-AMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRL 410
Query: 617 RIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAV 676
FL EE++P +++ G + IT+++ATF W++ PP L+ I ++P+G L+AV
Sbjct: 411 VTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLTVPQGCLLAV 470
Query: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQ 719
VG VG GKSSLLSALL E+ KVEG V+I+ +++Y+PQ
Sbjct: 471 VGPVGAGKSSLLSALLGELSKVEGFVSIE------GAVAYVPQ 507
Score = 82.0 bits (201), Expect = 4e-15
Identities = 62/222 (27%), Positives = 102/222 (45%), Gaps = 16/222 (7%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
L IN+T+ G + +VG GAGKSSL L EG + I+G
Sbjct: 455 LHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------------- 501
Query: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
+ +PQ+ + + S+ N+ + + LE L+ V + P+ + E G N
Sbjct: 502 VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMN 561
Query: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTI---RTQFEDCTVLTIAH 1371
LS GQ+Q + LARA+ RK + +LD+ AA+D + + + + T + + H
Sbjct: 562 LSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTH 621
Query: 1372 RLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDA 1413
L+ + +IVL G I E G+ +LLQ++G + A
Sbjct: 622 ALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQA 663
Score = 40.4 bits (93), Expect = 0.012
Identities = 20/47 (42%), Positives = 27/47 (57%)
Query: 658 PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
P + G++F I G V +VG+ G GKSSL S LL + EG + I
Sbjct: 1088 PLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWI 1134
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 589 bits (1518), Expect = e-168
Identities = 292/557 (52%), Positives = 387/557 (69%), Gaps = 13/557 (2%)
Query: 8 SADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRHDRGYIQM 67
S + WD N++ +T NPD T CFQN++L WVPC YLW P Y LYL H RGYI +
Sbjct: 7 SGELGSKFWDSNLSVHTENPDLTPCFQNSLLAWVPCIYLWVALPCYLLYLRHHCRGYIIL 66
Query: 68 TPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLATFLIQLE 127
+ L+K K LG LLW V WADLFYSF G APVF V+P ++G+TMLLAT LIQ E
Sbjct: 67 SHLSKLKMVLGVLLWCVSWADLFYSFHGLVHGRAPAPVFFVTPLVVGVTMLLATLLIQYE 126
Query: 128 RRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFSLLLIQLV 187
R +GVQSSG+++ FW + +VCA+ RSKI+ A E D FR TFY++F+L+L L+
Sbjct: 127 RLQGVQSSGVLIIFWFLCVVCAIVPFRSKILLAKAEGEISDPFRFTTFYIHFALVLSALI 186
Query: 188 LSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKE 247
L+CF ++ P FS DPNP PE+SA FLSR+ FWW T + + GYR PLE DLWSL +E
Sbjct: 187 LACFREKPPFFSAKNVDPNPYPETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEE 246
Query: 248 DTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQK 307
D S+ VV L++ W+K+ +T + K A P ++ A+ E E L+ P+
Sbjct: 247 DRSQMVVQQLLEAWRKQEKQTARH--------KASAAPGKN----ASGEDEVLLGARPRP 294
Query: 308 EWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYT 367
PS K L TFG FL+S FK I DL+ F PQ+L +LI+F+++ AP W G+
Sbjct: 295 R-KPSFLKALLATFGSSFLISACFKLIQDLLSFINPQLLSILIRFISNPMAPSWWGFLVA 353
Query: 368 VLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLM 427
L+F+ + +Q+L+L Y+H FV+G++ +T ++G +YRKALVITNS +++STVGEIVNLM
Sbjct: 354 GLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIYRKALVITNSVKRASTVGEIVNLM 413
Query: 428 SVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKT 487
SVDAQRFMDLA ++N++WSAPLQ+ILA+Y LW NLGPSVLAGVA MVL++P+N +A+K
Sbjct: 414 SVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKM 473
Query: 488 KTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA 547
+ +QV MK KD+RIKLM+EILNGIKVLKLYAWE +F +V IRQ EL++L+ +AYL
Sbjct: 474 RAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGIRQGELQLLRTAAYLHT 533
Query: 548 VGTFTWVCTPFLVALCT 564
TFTW+C+PFLV L T
Sbjct: 534 TTTFTWMCSPFLVRLGT 550
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 494 bits (1272), Expect = e-139
Identities = 293/725 (40%), Positives = 432/725 (59%), Gaps = 47/725 (6%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
K ILVTH + YL I+++ GK+ + G+Y E L F L+ +D E
Sbjct: 585 KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK--------KDNE 636
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
E+ V G + N R S SS +S SR L+ +
Sbjct: 637 ESEQPPVPG----TPTLRN-------------RTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALA---SNYWL 881
+ L E ++++ G+V Y +Y +A +I F IFL + N + +A ++WL
Sbjct: 680 ENVPV-TLSEENRSE-GKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWL 735
Query: 882 SLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV----FGYSMAVSIGGIL--AS 930
S W + + VNG T+ +L + LGI G+ V FG + ++ + +L +S
Sbjct: 736 SYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSS 794
Query: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGAC 990
+ LH + SIL++P+ FF+R P G ++NRFSK++ +D ++P F+ +L V+G
Sbjct: 795 QTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVV 854
Query: 991 IVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
V + P AI + PLG+I+ F++R+++ +SR +KRLES +RSPV+SH + +L G+ I
Sbjct: 855 SVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTI 914
Query: 1051 RAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSL 1110
RA++ +ER D D + +A++ + +RW AVRL+ + V+ A ++I +L
Sbjct: 915 RAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTL 974
Query: 1111 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1170
AG VGL++SY+L + W VR S+E+E +++VER+ EY++ EKEAPW+ Q+ PP+
Sbjct: 975 DAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPA 1034
Query: 1171 SWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINE 1230
WP G + F N Y VL+H+ I EKVGIVGRTGAGKSSL LFR++E
Sbjct: 1035 -WPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSE 1093
Query: 1231 SAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLEL 1290
EG+I ID I +IGLHDLR K++IIPQ+PVLF+G++R NLDPF++++DEE+W +L+
Sbjct: 1094 P-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQE 1152
Query: 1291 AHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD 1350
LK+ + LP K+D E AE G N SVGQRQLVCLARA+LRK +IL++DEATA VD TD
Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212
Query: 1351 DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR-GLFYSM 1409
+LIQ IR +F CTVLTIAHRLNTI+D +++VLD G ++EY P LLQ + LFY M
Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKM 1272
Query: 1410 AKDAG 1414
+ G
Sbjct: 1273 VQQLG 1277
Score = 240 bits (613), Expect = 6e-63
Identities = 150/520 (28%), Positives = 262/520 (50%), Gaps = 54/520 (10%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRI 708
G L+AVVG VG GKSSLLSA+L E+ G V++ RI
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI 475
Score = 83.2 bits (204), Expect = 2e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 933 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 988
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
Query: 989 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1048
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
Query: 1049 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
Query: 1108 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 1344 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 1403 RGLFYSMAK 1411
F S+ K
Sbjct: 624 GIDFGSLLK 632
Score = 44.7 bits (104), Expect = 6e-04
Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 10/121 (8%)
Query: 611 VSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPE 670
+S++R+ + E+ P ++RP I N F ++ P L +T I
Sbjct: 1008 ISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKS 1067
Query: 671 GALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTH--------SMSYLPQVDV 722
V +VG+ G GKSSL+SAL + + EG + I +IL T MS +PQ V
Sbjct: 1068 QEKVGIVGRTGAGKSSLISALF-RLSEPEGKIWI-DKILTTEIGLHDLRKKMSIIPQEPV 1125
Query: 723 I 723
+
Sbjct: 1126 L 1126
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 474 bits (1221), Expect = e-133
Identities = 280/730 (38%), Positives = 418/730 (57%), Gaps = 50/730 (6%)
Query: 698 VEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAST 757
+ H+ KT + VTH + YL D +I M G I+E G+++EL+ +G +A
Sbjct: 728 IRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLG 787
Query: 758 EQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTA 817
E E N SG K+++ D K T
Sbjct: 788 ETPP-VEINSKKETSGSQKKSQ---------DKGPK----------------------TG 815
Query: 818 ELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIF-LFMCNHVSALA 876
++K +A K E +L++ ++ G V SVY Y++A G ++FL I LFM N S
Sbjct: 816 SVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF 875
Query: 877 SNYWLSLWTDDPIVNGTQ---EHTKVRLSVYGALGISQGIAVFGYSMAVSI--------- 924
S +WLS W N T T V S+ + +++ SMAV +
Sbjct: 876 STWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVV 935
Query: 925 ---GGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMG 981
G + AS LH +L ILRSPM FF+ TP+G ++NRFSK++D VD +P +MF+
Sbjct: 936 FVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQ 995
Query: 982 SLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1041
++ V +I P + + PL +++ + R+LKRL+++++SP SH
Sbjct: 996 NVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHIT 1055
Query: 1042 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAAL 1101
++ G++ I A+ + + F+H+ +D+NQ ++ A RWLAVRL+ + ++ L
Sbjct: 1056 SSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGL 1115
Query: 1102 FAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAP 1160
V+ + GL++SY++Q+T + VR++SE E +VER+ Y +T EAP
Sbjct: 1116 MIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAP 1175
Query: 1161 WQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSS 1220
+I+ AP WPQ G V F N +RYRE+L VL+ ++ TI EK+GIVGRTG+GKSS
Sbjct: 1176 ARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSS 1235
Query: 1221 LTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYS 1280
L + LFR+ E + G I IDG+ I+ IGL DLR K++IIPQ+PVLFSG++R NLDPF+QY+
Sbjct: 1236 LGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYT 1295
Query: 1281 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1340
++++W +LE H+K+ ++ LP KL+ E E G+N SVG+RQL+C+ARALLR KIL+LDE
Sbjct: 1296 EDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDE 1355
Query: 1341 ATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1400
ATAA+D ETD LIQ TIR F DCT+LTIAHRL+T++ R++VL +G++ E+ PS LL
Sbjct: 1356 ATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL 1415
Query: 1401 -QQRGLFYSM 1409
FY+M
Sbjct: 1416 SNDSSRFYAM 1425
Score = 146 bits (369), Expect = 1e-34
Identities = 113/450 (25%), Positives = 210/450 (46%), Gaps = 49/450 (10%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQ-PLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAK 267
P +A S +TF W++ L +++ L D+WSL+K ++S+ L + W++E +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEELNE 159
Query: 268 TRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLM 327
D A SL +V++ ++
Sbjct: 160 V----------GPDAA----------------------------SLRRVVWIFCRTRLIL 181
Query: 328 SFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFH 386
S I L FSGP + K L+++ T++ + L +T +++ L +
Sbjct: 182 SIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTWA 241
Query: 387 ICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWS 446
+ + +G+R++ A++ ++K L + N KS +GE++N+ S D QR + A +++
Sbjct: 242 LNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICSNDGQRMFEAAAVGSLLAG 299
Query: 447 APLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN 506
P+ IL + + LGP+ G AV +L P + T ++ + + D R++ MN
Sbjct: 300 GPVVAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMN 359
Query: 507 EILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA 566
E+L IK +K+YAW AF V IR+EE ++L+K+ Y ++ + ++ TF+
Sbjct: 360 EVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFS 419
Query: 567 VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE 626
V++T+ + L A AF + +FN + F L + P + S+ +ASV++ R + EE+
Sbjct: 420 VHMTLGFD--LTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVH 477
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS 656
I+ +P I ++NAT W S
Sbjct: 478 --MIKNKPASP---HIKIEMKNATLAWDSS 502
Score = 90.1 bits (222), Expect = 1e-17
Identities = 66/215 (30%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 1191 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1250
L L I++ I G+ VGI G G+GK+SL + EG I I G
Sbjct: 574 LQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT--------- 624
Query: 1251 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1310
+ Q + + +LR N+ +Y +E + L L+ ++ LP E E
Sbjct: 625 ----FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGE 680
Query: 1311 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTI 1369
G NLS GQRQ + LARAL I +LD+ +A+D + + S IR + TVL +
Sbjct: 681 RGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFV 740
Query: 1370 AHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG 1404
H+L ++D VI + +G I E G +L+ G
Sbjct: 741 THQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
Score = 48.1 bits (113), Expect = 6e-05
Identities = 23/45 (51%), Positives = 31/45 (68%)
Query: 660 TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
TL+ I I EG LV + G VG GK+SL+SA+L +M +EG +AI
Sbjct: 577 TLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAI 621
Score = 39.3 bits (90), Expect = 0.027
Identities = 69/357 (19%), Positives = 142/357 (39%), Gaps = 34/357 (9%)
Query: 366 YTVLLFVTACLQTLVLHQYFHICFVSG-MRIKTAVIGAVYRKALVITNSARKSSTVGEIV 424
Y ++ + L+L + FV G +R + + ++R+ L ++ G I+
Sbjct: 913 YYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRIL 972
Query: 425 NLMSVDAQRFMDLATYINMIWSAPL---QVILALYLLWLNLG--PSVLAGVAVMVLMVPV 479
N S D + + + A + VIL + + + G P L V +V++ V
Sbjct: 973 NRFSKDMDE-----VDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSV 1027
Query: 480 NAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNGIKVLK-LYAWELAFKDKVLAIRQEEL 536
+++ + +K DN + ++ I + I+ L ++A+ K + R +EL
Sbjct: 1028 LHIVSRVL----IRELKRLDNITQSPFLSHITSSIQGLATIHAYN---KGQEFLHRYQEL 1080
Query: 537 KVLKKSAYLSAVGTFTWVCTPF----LVALCTFAVYVTIDENNILDAQTAFV---SLALF 589
++ + W+ + + T + + + I A ++ L
Sbjct: 1081 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLT 1140
Query: 590 NILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELE-PDSIERR-PVKDGGGTNSITVR 647
+ +F + + S S++R+ ++ LE P I+ + P D +T
Sbjct: 1141 GLFQFTVRLA----SETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFE 1196
Query: 648 NATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
NA + + P L ++F+I + +VG+ G GKSSL AL ++ G + I
Sbjct: 1197 NAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKI 1253
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 458 bits (1179), Expect = e-128
Identities = 268/716 (37%), Positives = 412/716 (57%), Gaps = 44/716 (6%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
+T +LVTH + YLP D II M G I G+ ++ + E +T + Q+Q+ E
Sbjct: 881 RTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMN-RQDQELE 939
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
+ VT ++A + G L R +SS D E ++ EA
Sbjct: 940 KETVTE-----RKATEPPQG----------LSRAMSSRDGLLQD--------EEEEEEEA 976
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
+ E + + Q ++ Y+ + G+ + L +F + H+ +A +YWL+ W
Sbjct: 977 AESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKW 1036
Query: 885 TDDPIV--------NGTQEHT------KVRLSVYGALGISQGIAVFGYSMAVSIGGILAS 930
TD + + +QE T + +V +LGI + S+ V G+ +
Sbjct: 1037 TDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVA 1093
Query: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGAC 990
+ LH LL+ I+ +PM FFE TP G+++NRFS + +T+D IP ++ S + A
Sbjct: 1094 KRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSAL 1153
Query: 991 IVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVI 1050
VI TP+ + + PL ++ +F+Q+++ +SR L++L+ ++ P+ SHF ET+ G++ I
Sbjct: 1154 AVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1213
Query: 1051 RAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS--RH 1108
RAF + RF + D N A ANRWL VR+E +G C+VL AA+ ++ +
Sbjct: 1214 RAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHR 1273
Query: 1109 SLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETA 1167
LSAGLVGL ++Y+L V+ YLNW+VR ++ME + AV+R+ +TE E+ + +
Sbjct: 1274 ELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSL 1333
Query: 1168 PPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
P +WP G+++ +N +RY L VL+H+N I G+K+GI GRTG+GKSS +L FR
Sbjct: 1334 IPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFR 1393
Query: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS 1287
+ ++ EG IIIDGI+IAK+ LH LR +++II QDPVLFSG++R NLDP + SD +W +
Sbjct: 1394 MVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEA 1453
Query: 1288 LELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDL 1347
LE+A LK V ALP LD EGGEN S GQRQL CLARA +RKT I ++DEATA++D+
Sbjct: 1454 LEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDM 1513
Query: 1348 ETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
T++++Q + T F D TV+TIAHR++TI+ VIVL +G I E+ P LL ++
Sbjct: 1514 ATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 211 bits (538), Expect = 3e-54
Identities = 154/553 (27%), Positives = 253/553 (45%), Gaps = 102/553 (18%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVK---NWKKECAKTRK 270
+ LS+ T+WW+ I +++P+ DL ++ K +P+ ++ N+++ C
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPI---DLRAIGK-------LPIAMRALTNYQRLCEAFDA 272
Query: 271 QPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFF 330
Q K + ++ ++++ L FG ++S
Sbjct: 273 QVRKDIQGTQGAR----------------------------AIWQALSHAFGRRLVLSST 304
Query: 331 FKAIHDLMMFSGPQILKLLIKFV---NDTKAPDWQ---------------GYFYTVLLFV 372
F+ + DL+ F+GP + ++ + ND P Q Y VLLF+
Sbjct: 305 FRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFL 364
Query: 373 TACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVD 430
LQ L +++ +G+ ++ A+ +Y K + ++ S + T G+I NL+++D
Sbjct: 365 ALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAID 424
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+ M +W+ P+Q+I+ + LL+ LG S L G AV++L+ PV +A K
Sbjct: 425 TNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA 484
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
Q + ++ + R+K NE+L GIK+LKLYAWE F+ +V R++E+ L+ A +++
Sbjct: 485 QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISI 544
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQAS 610
F P L TF +V+ + AF SL+LF+IL PL +L V+ S V+A
Sbjct: 545 FMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKAL 604
Query: 611 VSLKRLRIFLSHEELEPDSI-----------------------ERRPVK----------- 636
VS+++L FLS E+ + +RP +
Sbjct: 605 VSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQ 664
Query: 637 ------DGGGTN-SITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLS 689
DG N + + FTW PTL+ IT IP G L +VGQVGCGKSSLL
Sbjct: 665 SLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLL 724
Query: 690 ALLAEMDKVEGHV 702
A L EM KV G V
Sbjct: 725 AALGEMQKVSGAV 737
Score = 74.7 bits (182), Expect = 6e-13
Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 16/220 (7%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH----- 1249
L +I + I G+ IVG+ G GKSSL L + G + + ++IG
Sbjct: 696 LSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPER 755
Query: 1250 ------DLRFK--ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALP 1301
D+R + + Q P L + ++ N+ S ++ + +E L+ + LP
Sbjct: 756 ETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILP 815
Query: 1302 DKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQ 1360
+ E G NLS GQRQ + +ARAL + ++ LD+ +A+D+ +D L+Q+ I
Sbjct: 816 HGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILEL 875
Query: 1361 FED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSD 1398
D TV+ + H+L + +I + G IQ G D
Sbjct: 876 LRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKD 915
Score = 50.1 bits (118), Expect = 2e-05
Identities = 76/358 (21%), Positives = 149/358 (41%), Gaps = 39/358 (10%)
Query: 366 YTVL--LFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
+TVL L + CL T V ++ +G+++ + ++ + ++ +++ +G I
Sbjct: 1067 FTVLCSLGIVLCLVTSVTVEW------TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSI 1120
Query: 424 VNLMSVDAQRF-MDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAV 482
+N S D + + + + + L + AL ++ S + V +V ++P+ V
Sbjct: 1121 LNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVI------SYVTPV-FLVALLPLAIV 1173
Query: 483 MAMKTKTYQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEE 535
K ++VA ++ D+ +L E + G+ ++ + +E F+ K+L
Sbjct: 1174 CYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSN 1233
Query: 536 LKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNI-LDAQTAFVSLALFNILRF 594
S +L+A + V ++ A VT N++ + V L L L
Sbjct: 1234 NIA---SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMV 1290
Query: 595 PLNILPMVISSIVQASVSL---KRLRIFL-----SHEELEPDSIERRPVKDGGGTNSITV 646
N L ++ ++ + L KR+ L S+E L S+ + D G I +
Sbjct: 1291 S-NYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQG---KIQI 1346
Query: 647 RNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+N + + S P L + I G + + G+ G GKSS A +D EGH+ I
Sbjct: 1347 QNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIII 1404
Score = 32.7 bits (73), Expect = 2.5
Identities = 17/51 (33%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 703 AIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR-DGAFAEFLR 752
A +T + + H + + D++IV+ G I E ++LL+R D FA F+R
Sbjct: 1528 ADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1578
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 457 bits (1175), Expect = e-128
Identities = 258/713 (36%), Positives = 410/713 (57%), Gaps = 36/713 (5%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+ E
Sbjct: 864 RTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELE 922
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
++ EA Q L+R+ + YS + E ++ E
Sbjct: 923 KD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+ W
Sbjct: 962 DEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
Query: 885 TDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
T + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNK 1075
Query: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
Query: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
Query: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLL 1253
Query: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVE 1179
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G ++
Sbjct: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Query: 1180 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1239
+ C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+ID
Sbjct: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
Query: 1240 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1299
GI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +
Sbjct: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
Query: 1300 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1359
LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T
Sbjct: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
Query: 1360 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL-QQRGLFYSMAK 1411
F D TV+TIAHR++TI+ VIV+ +G I EY P LL Q+ G+F S +
Sbjct: 1494 AFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
Score = 219 bits (559), Expect = 1e-56
Identities = 163/548 (29%), Positives = 256/548 (46%), Gaps = 98/548 (17%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
L FL H ++P +I R RP
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 695 MDKVEGHV 702
M +EG V
Sbjct: 722 MQTLEGKV 729
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 972 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1030
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1031 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1090
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1091 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1141
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1142 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1183
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
Query: 1184 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1224
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
Query: 1225 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1280
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
Query: 1281 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1340
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
Query: 1341 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1397
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
Query: 1398 DL 1399
D+
Sbjct: 898 DI 899
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 71/473 (15%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+ + P L + I G V + G+ G GKSSL A +D +G + I
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
Score = 33.9 bits (76), Expect = 1.1
Identities = 18/51 (35%), Positives = 30/51 (58%), Gaps = 1/51 (1%)
Query: 703 AIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARD-GAFAEFLR 752
A +T + + H + + D++IVM G I E + + LLA++ G FA F+R
Sbjct: 1496 ADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 446 bits (1148), Expect = e-125
Identities = 254/711 (35%), Positives = 408/711 (57%), Gaps = 36/711 (5%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+ E
Sbjct: 828 RTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELE 886
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
++ EA Q L+R+ + YS + E ++ E
Sbjct: 887 KD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEE 925
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+ W
Sbjct: 926 DEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 982
Query: 885 TDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
T + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 983 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNK 1039
Query: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1040 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1099
Query: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1100 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1159
Query: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1160 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLL 1217
Query: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVE 1179
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G ++
Sbjct: 1218 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1277
Query: 1180 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1239
+ C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+ID
Sbjct: 1278 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1337
Query: 1240 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1299
GI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +
Sbjct: 1338 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1397
Query: 1300 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1359
LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T
Sbjct: 1398 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1457
Query: 1360 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1409
F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1458 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1508
Score = 230 bits (586), Expect = 8e-60
Identities = 160/510 (31%), Positives = 253/510 (49%), Gaps = 58/510 (11%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFLSHEELEPDSI---ERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGA 672
L FL +E+ DS E + ++ V N F+W S TL+ I IP G
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWG-SGLATLSNIDIRIPTGQ 663
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHV 702
L +VGQVGCGKSSLL A+L EM +EG V
Sbjct: 664 LTMIVGQVGCGKSSLLLAILGEMQTLEGKV 693
Score = 95.5 bits (236), Expect = 3e-19
Identities = 105/447 (23%), Positives = 198/447 (44%), Gaps = 39/447 (8%)
Query: 972 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1030
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1031 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1090
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1091 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1141
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1142 NIVAVERLKEY--SETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHIN 1199
I++V++L E+ S+ + W+ E++ P + N + L L +I+
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLA-TLSNID 656
Query: 1200 VTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLR----FKI 1255
+ I G+ IVG+ G GKSSL L + ++ EG++ +N ++ R + +
Sbjct: 657 IRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSV 716
Query: 1256 TIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENL 1315
Q P L + ++ N+ S ++ + + L+ + LP E E G NL
Sbjct: 717 AYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINL 776
Query: 1316 SVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHR 1372
S GQRQ +C+ARAL + T I+ LD+ +A+D+ +D L+Q I +D T++ + H+
Sbjct: 777 SGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHK 836
Query: 1373 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
L + +I + G + G D+
Sbjct: 837 LQYLTHADWIIAMKDGSVLREGTLKDI 863
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 71/473 (15%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 898 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 953
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 954 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1009
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1010 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1063
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1064 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1116
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1117 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1171
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1172 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1227
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1283
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+ + P L + I G V + G+ G GKSSL A +D +G + I
Sbjct: 1284 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1336
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 446 bits (1148), Expect = e-125
Identities = 254/711 (35%), Positives = 408/711 (57%), Gaps = 36/711 (5%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
+T +LVTH + YL D II M G + G+ +++ +D E +T + Q+Q+ E
Sbjct: 864 RTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMN-RQDQELE 922
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
++ EA Q L+R+ + YS + E ++ E
Sbjct: 923 KD---------MEADQTT------------LERKTLRRAMYSREAKAQMEDEDEEEEEEE 961
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLW 884
+++ M ++ W Y+ + G F+ L IF + H +A +YWL+ W
Sbjct: 962 DEDDN---MSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATW 1018
Query: 885 TDDPIVNGT----QEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHS 940
T + +N T Q + S+ GI + S+ V G+ A++ LH +LL+
Sbjct: 1019 TSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVT---SLTVEWMGLTAAKNLHHNLLNK 1075
Query: 941 ILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIA 1000
I+ P+ FF+ TP G ++NRFS + + +D IP ++ S + A +I ATP+
Sbjct: 1076 IILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVF 1135
Query: 1001 AIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFI 1060
+ + PLG+ ++F+Q+++ +S+ L+ L+ ++ P+ HF+ET G++ IRAF + RF
Sbjct: 1136 LVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFK 1195
Query: 1061 HQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVS 1120
+ D N AY ANRWL VR + +G CIVL A++ ++ S ++GLVGL +
Sbjct: 1196 QRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISG--SSNSGLVGLGLL 1253
Query: 1121 YSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEA-PWQIQETAPPSSWPQVGRVE 1179
Y+L +T YLNW+VR +++E + AV+++ + E E + + P WPQ G ++
Sbjct: 1254 YALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIK 1313
Query: 1180 FRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIID 1239
+ C+RY +L VL+H+ I G+KVGI GRTG+GKSSL+L FR+ + +G+I+ID
Sbjct: 1314 IHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVID 1373
Query: 1240 GINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSA 1299
GI+I+K+ LH LR +++II QDP+LFSGS+R NLDP + +D+ +W +LE+A LK+ V +
Sbjct: 1374 GIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKS 1433
Query: 1300 LPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRT 1359
LP LD EGGEN SVGQRQL CLARA +RK+ IL++DEATA++D+ T++++Q + T
Sbjct: 1434 LPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT 1493
Query: 1360 QFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG-APSDLLQQRGLFYSM 1409
F D TV+TIAHR+++IMD V+V +G + E P+ L + GLF ++
Sbjct: 1494 AFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTL 1544
Score = 219 bits (559), Expect = 1e-56
Identities = 163/548 (29%), Positives = 256/548 (46%), Gaps = 98/548 (17%)
Query: 214 SFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 273
+ LS+ T+WW+ LI+ +++P+ DL ++ K + + V V C K
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPI---DLKAIGKLPIAMRAVTNYV------CLK------ 265
Query: 274 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKA 333
DA EE + + P + PS++ +Y+ FG L+S F+
Sbjct: 266 ------------------DAYEEQKKKVADHPNR--TPSIWLAMYRAFGRPILLSSTFRY 305
Query: 334 IHDLMMFSGPQILKLLIKFVNDTKAPD----------------WQGYFYTVLLFVTACLQ 377
+ DL+ F+GP + +++ VN+T+ Y VLLF+ LQ
Sbjct: 306 LADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQ 365
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNS--ARKSSTVGEIVNLMSVDAQRFM 435
L +++ +G+ ++ A++ +Y K L ++ S + T+G+I NL++++ + M
Sbjct: 366 RTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLM 425
Query: 436 DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHM 495
+W+ P+Q+I+ + LL+ LG S L G AV+VL+ P+ +A K Q + +
Sbjct: 426 WFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTL 485
Query: 496 KSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVC 555
R+K NEIL GIK+LKLYAWE F V R +EL LK A +++ F
Sbjct: 486 DYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAA 545
Query: 556 TPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKR 615
P L TF + NN+ A+ AF SL+LF+IL PL +L V+ V+A +S+++
Sbjct: 546 IPIAAVLATFVTHAYASGNNLKPAE-AFASLSLFHILVTPLFLLSTVVRFAVKAIISVQK 604
Query: 616 LRIFL-----------------------SHEELEPDSIER------------------RP 634
L FL H ++P +I R RP
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRP 664
Query: 635 VKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAE 694
+ +I V N F+W S TL+ I IP G L +VGQVGCGKSSLL A+L E
Sbjct: 665 AET--EDIAIKVTNGYFSWG-SGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 721
Query: 695 MDKVEGHV 702
M +EG V
Sbjct: 722 MQTLEGKV 729
Score = 90.1 bits (222), Expect = 1e-17
Identities = 110/482 (22%), Positives = 205/482 (42%), Gaps = 73/482 (15%)
Query: 972 IPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLES 1030
+P I M + L+N++G+ ++ AA+I+ + YF + A L E
Sbjct: 437 MPVQIIMGVILLYNLLGSSALVG-----AAVIVLLAPIQYFIATKLAEAQKSTLDYSTER 491
Query: 1031 VSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLEC 1090
+ ++ NE L G+ +++ + + F V+E + S+ L L
Sbjct: 492 LKKT------NEILKGIKLLKLYAWEHIFCKS----VEETRMKELSSLKTFA-LYTSLSI 540
Query: 1091 VGNCIVLFAALFAVISRHSLSAG--------LVGLSVSYSLQVTTYL-NWLVRMSSEMET 1141
N + AA+ A H+ ++G LS+ + L +L + +VR + +
Sbjct: 541 FMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKA-- 598
Query: 1142 NIVAVERLKEY--SETEKEAPWQIQETAPPS--------------SWPQVGRVEFRNY-- 1183
I++V++L E+ S+ + W+ E++ P + Q GR +Y
Sbjct: 599 -IISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQ 657
Query: 1184 ---CLRYREDLDFVLR----------------HINVTINGGEKVGIVGRTGAGKSSLTLG 1224
LR E D ++ +I++ I G+ IVG+ G GKSSL L
Sbjct: 658 STRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLA 717
Query: 1225 LFRINESAEGEIIIDGINIAKIGLHDLR----FKITIIPQDPVLFSGSLRMNLDPFSQYS 1280
+ ++ EG++ +N ++ R + + Q P L + ++ N+ S ++
Sbjct: 718 ILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFN 777
Query: 1281 DEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDE 1340
+ + L+ + LP E E G NLS GQRQ +C+ARAL + T I+ LD+
Sbjct: 778 KQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 837
Query: 1341 ATAAVDLE-TDDLIQSTIRTQFED--CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1397
+A+D+ +D L+Q I +D T++ + H+L + +I + G + G
Sbjct: 838 PFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLK 897
Query: 1398 DL 1399
D+
Sbjct: 898 DI 899
Score = 46.2 bits (108), Expect = 2e-04
Identities = 100/473 (21%), Positives = 180/473 (38%), Gaps = 71/473 (15%)
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
RK + +YS + AQ ++ + + EE E + + + K+ +KT Y
Sbjct: 934 RKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRT----KMPWKTCWRYLTSG 989
Query: 329 FFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYF-----------YTVLLFVTACLQ 377
FF I LM+FS ++LK + D W + Y V F C
Sbjct: 990 GFFLLI--LMIFS--KLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGA 1045
Query: 378 TLVLHQYFHICFVSGMRIKTAVIGA-------VYRKALVITNSARKSSTVGEIVNLMSVD 430
+ L C V+ + ++ + A + K ++ ++ +G I+N S D
Sbjct: 1046 GIFL------CLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSAD 1099
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLN-LGPSVLAGVAVMVLMVPVNAVMAMKTKT 489
I+ L+ + LL L+ +G A +V ++P+ K
Sbjct: 1100 TN-------IIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKY 1152
Query: 490 YQVAH--MKSKDNRIKL-----MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKS 542
++VA ++ D+ +L +E G+ ++ + E FK ++L EL
Sbjct: 1153 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRML-----ELTDTNNI 1207
Query: 543 AYL--SAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP 600
AYL SA + V T +L A + + + + V L L L N L
Sbjct: 1208 AYLFLSAANRWLEVRTDYLGACIVLTASIASISGS---SNSGLVGLGLLYALTIT-NYLN 1263
Query: 601 MVISSIVQASVSL---KRLRIFLSHEE------LEPDSIERRPVKDGGGTNSITVRNATF 651
V+ ++ V + K++ FL+ E ++P + ++G I + +
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEG----EIKIHDLCV 1319
Query: 652 TWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+ + P L + I G V + G+ G GKSSL A +D +G + I
Sbjct: 1320 RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1372
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 429 bits (1102), Expect = e-119
Identities = 255/726 (35%), Positives = 403/726 (55%), Gaps = 48/726 (6%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
KT +LVTH + +L D +I++ G+I E G+++EL+ G +A+ + Q +D E
Sbjct: 653 KTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGL-QFKDPE 711
Query: 765 ENGVTGVSGPGKEA---KQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
+ KE+ ++ + G++V ++ + + S + S D
Sbjct: 712 HLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDT------------ 759
Query: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFI-SFLSIFLFMCNHVSALASNYW 880
K +L++ + Q G V Y Y+KA G ++ S ++FLF+ SA SN+W
Sbjct: 760 ----KVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWW 815
Query: 881 LSLWTDD-------PIVNGTQEHTKVRLSVYGA---LGISQGIAVFGYSMAVSIGGI--- 927
L LW D P N T L+ G + VF V+ G +
Sbjct: 816 LGLWLDKGSRMTCGPQGNRTMCEVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTK 875
Query: 928 ---LASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
+AS LH + IL+SPMSFF+ TP+G L+NRFSK++D +D +P + F+ F
Sbjct: 876 TTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFF 935
Query: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
V+ +++ P +++ L + +F + R + ++LK++E+VSRSP ++H ++
Sbjct: 936 MVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSM 995
Query: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
G+ +I A+ ++E I L + A RW A+R++ + N + AL
Sbjct: 996 QGLGIIHAYGKKESCITYHLLYFN----------CALRWFALRMDVLMNILTFTVALLVT 1045
Query: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
+S S+S GLS+SY +Q++ L VR +E + +VE L+EY T E +
Sbjct: 1046 LSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPL 1105
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
+ P WP G + FR+Y +RYR++ VL +N+ I G+ VGIVGRTG+GKSSL +
Sbjct: 1106 KVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
LFR+ E A G I ID ++I + L DLR K+T+IPQDPVLF G++R NLDPF ++DE
Sbjct: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESHTDEM 1225
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
+W LE ++D + LP+KL E E GEN SVG+RQL+C+ARALLR +KI++LDEATA
Sbjct: 1226 LWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATA 1285
Query: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
++D +TD L+Q+TI+ F+ CTVLTIAHRLNT+++ V+V++ G++ E+ P L ++
Sbjct: 1286 SMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLAEKP 1345
Query: 1404 GLFYSM 1409
++M
Sbjct: 1346 DSAFAM 1351
Score = 163 bits (413), Expect = 1e-39
Identities = 133/557 (23%), Positives = 241/557 (43%), Gaps = 93/557 (16%)
Query: 207 PCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECA 266
P P A LS TF W+T ++V+GYRQ L L L+ D+S+ W +E A
Sbjct: 43 PNPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVA 102
Query: 267 KTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFL 326
+ P+K SL V++K L
Sbjct: 103 RV-----------------------------------GPEKA---SLSHVVWKFQRTRVL 124
Query: 327 MSFFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYF 385
M + +M GP IL +++ T W G + LF T + +
Sbjct: 125 MDIVANILCIIMAAIGPVILIHQILQQTERTSGKVWVGIGLCIALFATEFTKVFFWALAW 184
Query: 386 HICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIW 445
I + + +R+K A+ V+ +++ +VGE++N++S D+ + A + +
Sbjct: 185 AINYRTAIRLKVALSTLVFEN--LVSFKTLTHISVGEVLNILSSDSYSLFEAALFCPLPA 242
Query: 446 SAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLM 505
+ P+ ++ + LGP+ L G++V V+ +PV MA ++ + + D R++ M
Sbjct: 243 TIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTM 302
Query: 506 NEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTF 565
NE L I+++K+YAWE +F + + IR+ E K+L+K+ ++ + + + + T
Sbjct: 303 NEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTL 362
Query: 566 AVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEEL 625
+ ++ + L A AF +A+FN+++F + ILP I ++ +A+VSL+R++ L +
Sbjct: 363 SCHILLRRK--LTAPVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILI--DK 418
Query: 626 EPDSIERRPVKDGGGTNSITVRNATFTW-----------------------------ARS 656
P S +P + + NAT TW +
Sbjct: 419 SPPSYITQPEDP---DTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSER 475
Query: 657 DPP----------------TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEG 700
PP L+ I+F + +G ++ + G VG GKSSLL+ALL +M +G
Sbjct: 476 SPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKG 535
Query: 701 HVAIKTRILVTHSMSYL 717
VA+ + +++
Sbjct: 536 VVAVNGTLAYVSQQAWI 552
Score = 90.5 bits (223), Expect = 1e-17
Identities = 62/219 (28%), Positives = 107/219 (48%), Gaps = 14/219 (6%)
Query: 1189 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1248
+ L VL I+ + G+ +GI G G+GKSSL L + +G + ++G
Sbjct: 490 DSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT------- 542
Query: 1249 HDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHEC 1308
+ + Q +F G++R N+ +Y + ++ + L+ +S LP E
Sbjct: 543 ------LAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEI 596
Query: 1309 AEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVL 1367
E G NLS GQRQ + LARA+ ++ +LD+ +AVD + + I+ TV+
Sbjct: 597 GERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVV 656
Query: 1368 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1406
+ H+L + VI+L+ GEI E G +L+++RG +
Sbjct: 657 LVTHQLQFLESCDEVILLEDGEICEKGTHKELMEERGRY 695
Score = 39.3 bits (90), Expect = 0.027
Identities = 22/69 (31%), Positives = 33/69 (47%)
Query: 636 KDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 695
KD IT R+ + + P L+ + +I G V +VG+ G GKSSL AL +
Sbjct: 1112 KDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLV 1171
Query: 696 DKVEGHVAI 704
+ G + I
Sbjct: 1172 EPASGTIFI 1180
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 404 bits (1038), Expect = e-112
Identities = 243/725 (33%), Positives = 389/725 (53%), Gaps = 58/725 (8%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761
KT +LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ Q
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
D + E ++E+ L T S S +G+ H T E
Sbjct: 744 DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780
Query: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880
++ + G + VY Y++A G ++ IF F+ V + S +W
Sbjct: 781 --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826
Query: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928
LS W + + + ++ G + + ++ V+G + + V GI
Sbjct: 827 LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886
Query: 929 ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+
Sbjct: 887 VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946
Query: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
VI +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L
Sbjct: 947 MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006
Query: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
G+S I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP +
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
+ T+ P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL +
Sbjct: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
LFR+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D++
Sbjct: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
+W +LE L +S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA
Sbjct: 1247 IWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATA 1306
Query: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
++D+ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++
Sbjct: 1307 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1366
Query: 1404 GLFYS 1408
G ++
Sbjct: 1367 GSLFA 1371
Score = 108 bits (270), Expect = 4e-23
Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571
Query: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764
S++Y+PQ I+ G+ +E + GA+ A +L+ +D E
Sbjct: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 39.3 bits (90), Expect = 0.027
Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+V +VG+ G GKSSL AL ++ + G + I
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 404 bits (1038), Expect = e-112
Identities = 243/725 (33%), Positives = 389/725 (53%), Gaps = 58/725 (8%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761
KT +LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ Q
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
D + E ++E+ L T S S +G+ H T E
Sbjct: 744 DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780
Query: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880
++ + G + VY Y++A G ++ IF F+ V + S +W
Sbjct: 781 --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826
Query: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928
LS W + + + ++ G + + ++ V+G + + V GI
Sbjct: 827 LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886
Query: 929 ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+
Sbjct: 887 VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946
Query: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
VI +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L
Sbjct: 947 MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006
Query: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
G+S I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP +
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
+ T+ P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL +
Sbjct: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
LFR+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D++
Sbjct: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
+W +LE L +S P KL + E G N SVG+RQL+C+ARA+LR +KI+++DEATA
Sbjct: 1247 IWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEATA 1306
Query: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
++D+ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++
Sbjct: 1307 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1366
Query: 1404 GLFYS 1408
G ++
Sbjct: 1367 GSLFA 1371
Score = 108 bits (270), Expect = 4e-23
Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571
Query: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764
S++Y+PQ I+ G+ +E + GA+ A +L+ +D E
Sbjct: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 39.3 bits (90), Expect = 0.027
Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+V +VG+ G GKSSL AL ++ + G + I
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 398 bits (1023), Expect = e-110
Identities = 260/795 (32%), Positives = 410/795 (51%), Gaps = 103/795 (12%)
Query: 663 GITFSIPEGALVAVVGQVGCGKSS-LLSALLAEMDK----------VEGHVAIKTRILVT 711
G+T S + A +A+ V K LL LA +D + G ++ TR+L T
Sbjct: 695 GVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCT 754
Query: 712 HSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGV 771
H YL + D +++M G++ G E+L A + A E Q+++ V
Sbjct: 755 HRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK-----AWAENGQESDSATAQSV 809
Query: 772 SGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWK 831
P K + +E +++ L + E+KKE
Sbjct: 810 QNPEKTKEGLEE----------------------------EQSTSGRLLQEESKKE---- 837
Query: 832 LMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDD-PIV 890
G V L VY Y KA+G ++ +F + + A+++WLS W
Sbjct: 838 ---------GAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAE 888
Query: 891 NGTQE-----------------------------------------HTKVRLSVYGALGI 909
N +QE + L+VY +
Sbjct: 889 NSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG 948
Query: 910 SQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVD 969
+ ++ + G + A+ LH LLH +L +P++FF TP+G ++NRFS ++ D
Sbjct: 949 VNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACAD 1008
Query: 970 SMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLE 1029
+P ++ + + + ++G V+ P +++PPL ++Y+ VQR Y ASSR+L+RL
Sbjct: 1009 DSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
Query: 1030 SVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLE 1089
S++ SP+YSH +TL G+SV+RA RF ++ ++ NQ+ + + +WL +RL+
Sbjct: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
Query: 1090 CVGNCIVLFAALFAVISRHS--LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE 1147
+G +V A A++ + GLVGLS+SY+L +T L+ LV ++ E +V+VE
Sbjct: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
Query: 1148 RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEK 1207
RL+EY+ + P Q Q + W G VEF++ L YR L L + + GEK
Sbjct: 1189 RLEEYTCDLPQEP-QGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEK 1247
Query: 1208 VGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSG 1267
+GIVGRTG+GKSSL L LFR+ E + G +++DG++ +++ L LR ++ IIPQ+P LFSG
Sbjct: 1248 LGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSG 1307
Query: 1268 SLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLAR 1327
++R NLDP + D +W +L+ HL + ++++ LD E EGG +LS+GQRQL+CLAR
Sbjct: 1308 TVRENLDPQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLAR 1366
Query: 1328 ALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDK 1387
ALL KIL +DEATA+VD +TD L+Q TI +F + TVLTIAHRLNTI++ RV+VL
Sbjct: 1367 ALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQA 1426
Query: 1388 GEIQEYGAPSDLLQQ 1402
G + E +P+ L Q
Sbjct: 1427 GRVVELDSPATLRNQ 1441
Score = 212 bits (539), Expect = 2e-54
Identities = 133/420 (31%), Positives = 218/420 (51%), Gaps = 28/420 (6%)
Query: 306 QKEWNPS--LFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQG 363
Q W L++ LY FG +L K + ++ FSGP +L LL+ F+ + + P G
Sbjct: 221 QAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHG 280
Query: 364 YFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEI 423
Y + L A L ++ +QY + + ++ + AV+ +Y KAL + S + GE
Sbjct: 281 LLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPT---GEA 337
Query: 424 VNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVM 483
+NL+ D++R ++ A + W PLQ+ + LYLL+ +G + + G+ + +L+VPVN V+
Sbjct: 338 LNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVI 397
Query: 484 AMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSA 543
A + ++ KD R+KL+ E+L+GI+V+K WE A +V A R EL L+
Sbjct: 398 ATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIK 457
Query: 544 YLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVI 603
YL A + W P ++++ F YV + L A F +LAL +L PLN P VI
Sbjct: 458 YLDAACVYLWAALPVVISIVIFITYVLMGHQ--LTATKVFTALALVRMLILPLNNFPWVI 515
Query: 604 SSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGG--------------TNSITVRNA 649
+ +++A VSL R+++FL P + G + + + A
Sbjct: 516 NGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGA 575
Query: 650 TFTWARSDPPTLNGITF----SIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIK 705
F+W DP + TF + +G LV +VG+VGCGKSSLL+A+ E+ ++ GHVA++
Sbjct: 576 LFSW---DPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR 632
Score = 73.6 bits (179), Expect = 1e-12
Identities = 60/212 (28%), Positives = 99/212 (46%), Gaps = 15/212 (7%)
Query: 1191 LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHD 1250
L+ + H+ V G VGIVG+ G GKSSL + G + + G++
Sbjct: 586 LETFISHLEV--KKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG------ 637
Query: 1251 LRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTS-LELAHLKDFVSALPDKLDHECA 1309
+ Q+P + ++R N+ F + D +++ LE L D +S LP E
Sbjct: 638 ----FGLATQEPWIQFATIRDNI-LFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 692
Query: 1310 EGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLE-TDDLIQSTIRTQFEDCTVLT 1368
E G LS GQR + LARA+ ++ ++ +LD+ AAVD + + L+ I T L
Sbjct: 693 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL 752
Query: 1369 IAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLL 1400
HR + V++++ G + G PS++L
Sbjct: 753 CTHRTEYLERADAVLLMEAGRLIRAGPPSEIL 784
Score = 47.0 bits (110), Expect = 1e-04
Identities = 66/306 (21%), Positives = 125/306 (40%), Gaps = 35/306 (11%)
Query: 417 SSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM 476
++ G I+N S D D +I L ++LA L L + +G+ ++L+
Sbjct: 990 ATPTGRILNRFSSDVACADDSLPFI-------LNILLANAAGLLGLLAVLGSGLPWLLLL 1042
Query: 477 VPVNAVMAMKTKTYQVAHMKSKDNRIKL--------MNEILNGIKVLKLYAWELAFKDKV 528
+P ++M + + A + L + + L G+ VL+ F+++
Sbjct: 1043 LPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEEN 1102
Query: 529 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLAL 588
L + + L + + T W+ + L AV I ++ Q + L
Sbjct: 1103 LRLLE-----LNQRCQFATSATMQWL--DIRLQLMGAAVVSAIAGIALVQHQQGLANPGL 1155
Query: 589 FNI-LRFPLNI---LPMVISSIVQAS---VSLKRLRIFLSHEELEPDSIERRPVKDGGG- 640
+ L + L++ L ++SS Q VS++RL + EP +P++ G G
Sbjct: 1156 VGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQG---QPLQLGTGW 1212
Query: 641 --TNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKV 698
+ ++ + P L+G+TF + G + +VG+ G GKSSLL L ++
Sbjct: 1213 LTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPS 1272
Query: 699 EGHVAI 704
G V +
Sbjct: 1273 SGRVLL 1278
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 347 bits (889), Expect = 6e-95
Identities = 225/725 (31%), Positives = 364/725 (50%), Gaps = 96/725 (13%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTY---ASTEQEQ 761
KT +LVTH + YL II++ GKI E G++ EL+ + G +A+ ++ A+++ Q
Sbjct: 684 KTVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQ 743
Query: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
D + E ++E+ L T S S +G+ H T E
Sbjct: 744 DTAKIA---------EKPKVESQALAT-----------SLEESLNGNAVPEHQLTQE--- 780
Query: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVS-ALASNYW 880
++ + G + VY Y++A G ++ IF F+ V + S +W
Sbjct: 781 --------------EEMEEGSLSWRVYHHYIQAAGGYMVSCIIFFFVVLIVFLTIFSFWW 826
Query: 881 LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIA----VFGYS------MAVSIGGIL-- 928
LS W + + + ++ G + + ++ V+G + + V GI
Sbjct: 827 LSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTK 886
Query: 929 ----ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLF 984
AS LH L + + R PMSFF+ P G L+N F+ +L+ +D ++P + F+
Sbjct: 887 VTRKASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSL 946
Query: 985 NVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETL 1044
VI +++ + +P ++ + +I F + + KRLE+ SRSP++SH +L
Sbjct: 947 MVIAVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSL 1006
Query: 1045 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAV 1104
G+S I + + E FI Q D + + RW+A+RLE + N + L ALF
Sbjct: 1007 QGLSSIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVA 1066
Query: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSET-EKEAPWQI 1163
S ++V+ LQ+ + R+ E E AVER+ +Y + EAP +
Sbjct: 1067 FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPLHM 1126
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
+ T+ P WPQ G + F++Y ++YR++ VL IN+TI G E VGIVGRTG+GKSSL +
Sbjct: 1127 EGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGM 1186
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
LFR+ E G I+IDG++I IGL DLR K+++IPQDPVL SG++R NLDPF +++D++
Sbjct: 1187 ALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRHTDQQ 1246
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
+W +LE R L K I+++DEATA
Sbjct: 1247 IWDALE-------------------------------------RTFLTKA-IILIDEATA 1268
Query: 1344 AVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQR 1403
++D+ETD LIQ TIR F+ CTVL IAHR+ T+++ ++V+ G++ E+ P L ++
Sbjct: 1269 SIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKKP 1328
Query: 1404 GLFYS 1408
G ++
Sbjct: 1329 GSLFA 1333
Score = 108 bits (270), Expect = 4e-23
Identities = 122/600 (20%), Positives = 243/600 (40%), Gaps = 103/600 (17%)
Query: 205 PNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKE 264
P P P +A S +T W+T L+++ R L+ + + L+ D S++ V L + W++E
Sbjct: 81 PAPQPLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEE 140
Query: 265 CAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPY 324
++ + V+ L++ Q+ +F L G
Sbjct: 141 VSRRGIEKASVL-----------------------LVMLRFQR--TRLIFDAL---LGIC 172
Query: 325 FLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQY 384
F ++ I I+ ++++ + G LF++ C+++L
Sbjct: 173 FCIASVLGPI---------LIIPKILEYSEEQLGNVVHGVGLCFALFLSECVKSLSFSSS 223
Query: 385 FHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMI 444
+ I + +R + AV + K + + +S GE ++ + D + Y ++
Sbjct: 224 WIINQRTAIRFRAAVSSFAFEKLIQFKSVIHITS--GEAISFFTGDVNYLFEGVCYGPLV 281
Query: 445 WSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKL 504
+++ + +G + + +L+ P+ M Q + D RI++
Sbjct: 282 LITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAVFMTRMAVKAQHHTSEVSDQRIRV 341
Query: 505 MNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCT 564
+E+L IK++K+Y WE F + +R++E K+L+K + ++ + T F++
Sbjct: 342 TSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEKCGLVQSLTSITL----FIIPTVA 397
Query: 565 FAVYVTIDEN--NILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSH 622
AV+V I + L A AF LA N+LR + +P+ + + + ++ R + F
Sbjct: 398 TAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQ 457
Query: 623 EELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNG------------------- 663
E + ++D + ++ AT +W ++ P +NG
Sbjct: 458 ES---PVFYVQTLQD--PSKALVFEEATLSWQQTCPGIVNGALELERNGHASEGMTRPRD 512
Query: 664 -----------------ITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKT 706
I + +G ++ V G G GKSSLLSA+L EM +EG V ++
Sbjct: 513 ALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQ- 571
Query: 707 RILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAF--AEFLRTYASTEQEQDAE 764
S++Y+PQ I+ G+ +E + GA+ A +L+ +D E
Sbjct: 572 -----GSLAYVPQQAWIV---------SGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Score = 90.9 bits (224), Expect = 8e-18
Identities = 65/224 (29%), Positives = 105/224 (46%), Gaps = 18/224 (8%)
Query: 1195 LRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFK 1254
L IN+ ++ G +G+ G TG+GKSSL + EG + + G
Sbjct: 527 LHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG-------------S 573
Query: 1255 ITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGEN 1314
+ +PQ + SG++R N+ Y L L + LP E E G N
Sbjct: 574 LAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGERGLN 633
Query: 1315 LSVGQRQLVCLARALLRKTKILVLDEATAAVDLET-DDLIQSTIRTQFEDCTVLTIAHRL 1373
LS GQ+Q + LARA+ +I +LD+ +AVD + + I+ TV+ + H+L
Sbjct: 634 LSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQL 693
Query: 1374 NTIMDYTRVIVLDKGEIQEYGAPSDLLQQRG----LFYSMAKDA 1413
+ ++I+L+ G+I E G S+L+Q++G L M K+A
Sbjct: 694 QYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEA 737
Score = 39.3 bits (90), Expect = 0.027
Identities = 64/332 (19%), Positives = 134/332 (40%), Gaps = 41/332 (12%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVIL 453
+ TA+ ++ K S + +G ++N + D ++ L + + +++
Sbjct: 890 KASTALHNKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVI 949
Query: 454 ALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDN--RIKLMNEILNG 511
A+ L+ L P +L A+++++ + +M K + K +N R L + ILN
Sbjct: 950 AVLLIVSVLSPYILLMGAIIMVICFIYYMMFKKA----IGVFKRLENYSRSPLFSHILNS 1005
Query: 512 IKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTI 571
++ L + + K + + + L + + L + + W+ A+ + I
Sbjct: 1006 LQGLS--SIHVYGKTEDFISQFKRLTDAQNNYLLLFLSSTRWM-----------ALRLEI 1052
Query: 572 DENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIE 631
N + A FV+ F I P + M ++ ++Q + S + E + ++E
Sbjct: 1053 MTNLVTLAVALFVA---FGISSTPYSFKVMAVNIVLQLASSFQATARIGLETEAQFTAVE 1109
Query: 632 R-----------RPVKDGGGT--------NSITVRNATFTWARSDPPTLNGITFSIPEGA 672
R P+ G + I ++ + + P L+GI +I
Sbjct: 1110 RILQYMKMCVSEAPLHMEGTSCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHE 1169
Query: 673 LVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
+V +VG+ G GKSSL AL ++ + G + I
Sbjct: 1170 VVGIVGRTGSGKSSLGMALFRLVEPMAGRILI 1201
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 904 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 961
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Query: 962 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1021
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
Query: 1022 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1081
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
Query: 1082 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1141
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
Query: 1142 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1182
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
Query: 1183 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1242
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
Query: 1243 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1302
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
Query: 1303 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1362
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
Query: 1363 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1406
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
Score = 142 bits (359), Expect = 2e-33
Identities = 113/543 (20%), Positives = 222/543 (40%), Gaps = 84/543 (15%)
Query: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
Query: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
+ NP L L + F F+
Sbjct: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
Query: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
Query: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
Query: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
Query: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
Query: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Query: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
+ ++ T + + N T W
Sbjct: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
Query: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSM 714
P L I F I G L+AV G G GK+SLL ++ E++ EG + RI
Sbjct: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
Query: 715 SYL 717
S++
Sbjct: 495 SWI 497
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 1194 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1253
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
Query: 1254 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1313
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
Query: 1314 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1372
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
Query: 1373 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
+ + ++++L +G YG S+L
Sbjct: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
Score = 42.4 bits (98), Expect = 0.003
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
Query: 685 SSLLSALLAEMDKVEGHVAI 704
S+LLSA L ++ EG + I
Sbjct: 1251 STLLSAFLRLLN-TEGEIQI 1269
Score = 33.9 bits (76), Expect = 1.1
Identities = 21/67 (31%), Positives = 32/67 (47%)
Query: 702 VAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQ 761
+A KTRILVT M +L + D I+++ G G++ EL F+ L S +Q
Sbjct: 595 MANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFS 654
Query: 762 DAEENGV 768
N +
Sbjct: 655 AERRNSI 661
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 240 bits (613), Expect = 6e-63
Identities = 150/520 (28%), Positives = 262/520 (50%), Gaps = 54/520 (10%)
Query: 196 PLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVP 255
P++ E P P A+ SR+ FWW+ L G+++ LE D++S+ ED S+ +
Sbjct: 3 PVYQEV----KPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGE 58
Query: 256 VLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFK 315
L W KE + K PSL +
Sbjct: 59 ELQGFWDKEVLRAENDAQK------------------------------------PSLTR 82
Query: 316 VLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVN-----DTKAPDWQGYFYTVLL 370
+ K + +L+ F I + P L +I + D+ A + + TVL
Sbjct: 83 AIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLT 142
Query: 371 FVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVD 430
F T L ++ H YF+ +GMR++ A+ +YRKAL ++N A +T G+IVNL+S D
Sbjct: 143 FCTLIL-AILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSND 201
Query: 431 AQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTY 490
+F + +++ +W+ PLQ I LLW+ +G S LAG+AV+++++P+ + +
Sbjct: 202 VNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSL 261
Query: 491 QVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGT 550
+ D RI+ MNE++ GI+++K+YAWE +F + + +R++E+ + +S+ L +
Sbjct: 262 RSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNL 321
Query: 551 FTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQA 609
++ ++ TF YV + +++ A FV++ L+ +R + + P I + +A
Sbjct: 322 ASFFSASKIIVFVTFTTYVLL--GSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 610 SVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWAR-SDPPTLNGITFSI 668
VS++R++ FL +E+ +R G + V++ T W + S+ PTL G++F++
Sbjct: 380 IVSIRRIQTFLLLDEIS----QRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV 435
Query: 669 PEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRI 708
G L+AVVG VG GKSSLLSA+L E+ G V++ RI
Sbjct: 436 RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRI 475
Score = 92.8 bits (229), Expect = 2e-18
Identities = 81/283 (28%), Positives = 134/283 (47%), Gaps = 44/283 (15%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAE 764
K ILVTH + YL I+++ GK+ + G+Y E L F L+ +D E
Sbjct: 585 KITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLLK--------KDNE 636
Query: 765 ENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEA 824
E+ V G + N R S SS +S SR L+ +
Sbjct: 637 ESEQPPVPG----TPTLRN-------------RTFSESSVWSQQSSRPSLKDGALESQDT 679
Query: 825 KKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALA---SNYWL 881
+ L E ++++ G+V Y +Y +A +I F IFL + N + +A ++WL
Sbjct: 680 ENVPV-TLSEENRSE-GKVGFQAYKNYFRAGAHWIVF--IFLILLNTAAQVAYVLQDWWL 735
Query: 882 SLWTD-----DPIVNGTQEHTKVRLSVYGALGISQGIAV----FGYSMAVSIGGIL--AS 930
S W + + VNG T+ +L + LGI G+ V FG + ++ + +L +S
Sbjct: 736 SYWANKQSMLNVTVNGGGNVTE-KLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSS 794
Query: 931 RCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP 973
+ LH + SIL++P+ FF+R P G ++NRFSK++ +D ++P
Sbjct: 795 QTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLP 837
Score = 83.2 bits (204), Expect = 2e-15
Identities = 106/489 (21%), Positives = 204/489 (41%), Gaps = 32/489 (6%)
Query: 933 LHVDLLHSILRSPMSFFE----RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIG 988
L V + H I R + +T +G +VN S +++ D + + ++ G L I
Sbjct: 166 LRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPL-QAIA 224
Query: 989 ACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVS 1048
++ + I+ + + +I +Q + L+ + NE + G+
Sbjct: 225 VTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIR 284
Query: 1049 VIRAFEEQERFIHQ-SDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISR 1107
+I+ + ++ F + ++L+ E K S + LA IV V+
Sbjct: 285 IIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSA-SKIIVFVTFTTYVLLG 343
Query: 1108 HSLSAGLVGLSVSY----SLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI 1163
++A V ++V+ L VT + + SE IV++ R++ + ++ + Q
Sbjct: 344 SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA---IVSIRRIQTFLLLDEIS--QR 398
Query: 1164 QETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
P V +F + + E L+ ++ T+ GE + +VG GAGKSSL
Sbjct: 399 NRQLPSDGKKMVHVQDFTAFWDKASETP--TLQGLSFTVRPGELLAVVGPVGAGKSSLLS 456
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEE 1283
+ + G + + G +I + Q P +FSG+LR N+ +Y E
Sbjct: 457 AVLGELAPSHGLVSVHG-------------RIAYVSQQPWVFSGTLRSNILFGKKYEKER 503
Query: 1284 VWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATA 1343
++ LK + L D + G LS GQ+ V LARA+ + I +LD+ +
Sbjct: 504 YEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLS 563
Query: 1344 AVDLETD-DLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
AVD E L + I + + + H+L + +++++L G++ + G ++ L+
Sbjct: 564 AVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKS 623
Query: 1403 RGLFYSMAK 1411
F S+ K
Sbjct: 624 GIDFGSLLK 632
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 177 bits (449), Expect = 6e-44
Identities = 143/488 (29%), Positives = 238/488 (48%), Gaps = 21/488 (4%)
Query: 933 LHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIK--MFMGSLFNVIGAC 990
L L SILR ++FF++T +G L+NR S + + + E + + G+ +V G
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASV-GIS 305
Query: 991 IVILLATPIAAII---IPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGV 1047
++ ++ +A + +PP+ +I R+ R+L ++ S + E + V
Sbjct: 306 MMFFVSPNLATFVLSVVPPVSIIAVIYGRYL----RKLTKVTQDSLAQATQLAEERIGNV 361
Query: 1048 SVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFA---V 1104
+RAF ++ I + KVD + A GN IVL + L+ +
Sbjct: 362 RTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVL-SVLYKGGLL 420
Query: 1105 ISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQ 1164
+ ++ G + + Y+ V + L SE+ + A RL E E E + P+
Sbjct: 421 MGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEG 480
Query: 1165 ETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTL 1223
S+ G +EF+N Y + + + +++I G +VG +G+GKS++
Sbjct: 481 VILNEKSFQ--GALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLS 538
Query: 1224 GLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL----DPFSQY 1279
L R+ + A G I +DG +I ++ LR KI + Q+P+LFS S+ N+ D S
Sbjct: 539 LLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSV 598
Query: 1280 SDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLD 1339
+ EE+ E+A+ F+ P + E G LS GQ+Q + +ARALL+ KIL+LD
Sbjct: 599 TAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLD 658
Query: 1340 EATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
EAT+A+D E + L+Q + + TVL IAHRL+TI + V VLD+G+I EYG +L
Sbjct: 659 EATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEEL 718
Query: 1400 LQQRGLFY 1407
L + Y
Sbjct: 719 LSKPNGIY 726
Score = 47.4 bits (111), Expect = 1e-04
Identities = 64/325 (19%), Positives = 136/325 (41%), Gaps = 31/325 (9%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRF-MDLATYINMIWSAPLQVI 452
R++T++ ++ R+ + + R GE++N +S D + ++ A Q
Sbjct: 246 RLRTSLFSSILRQEVAFFDKTR----TGELINRLSSDTALLGRSVTENLSDGLRAGAQAS 301
Query: 453 LALYLLWL---NLGPSVLAGVA-VMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI 508
+ + +++ NL VL+ V V ++ V + TK Q S +L E
Sbjct: 302 VGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQ----DSLAQATQLAEER 357
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSA--------VGTFTWVCTPFLV 560
+ ++ ++ + E+ +K + +++ +K A+ A G + +
Sbjct: 358 IGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKG 417
Query: 561 ALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFL 620
L + ++T+ E + +V +++ + F S +++ + RL L
Sbjct: 418 GLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF--------YSELMKGLGAGGRLWELL 469
Query: 621 SHEELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQ 679
E P + E + + ++ +N F + AR + P + SIP G++ A+VG
Sbjct: 470 EREPKLPFN-EGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGP 528
Query: 680 VGCGKSSLLSALLAEMDKVEGHVAI 704
G GKS++LS LL D G +++
Sbjct: 529 SGSGKSTVLSLLLRLYDPASGTISL 553
Score = 33.9 bits (76), Expect = 1.1
Identities = 12/39 (30%), Positives = 27/39 (69%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
+T +++ H +S + +++ V+ GKI+E G ++ELL++
Sbjct: 683 RTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSK 721
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 168 bits (425), Expect = 4e-41
Identities = 171/732 (23%), Positives = 326/732 (44%), Gaps = 68/732 (9%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS---TEQEQ 761
+T I++ H +S + DVI G I E G++ EL+ G + + + + E E
Sbjct: 580 RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELEN 639
Query: 762 DAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQK 821
A+E+ E +E M DS ++++ + S ST E
Sbjct: 640 AADESK--------SEIDALE--MSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALD 689
Query: 822 AEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWL 881
W++M+ + + W Y +G+F + ++ L A+ + +
Sbjct: 690 ESIPPVSFWRIMKLNLTE---------WPYF-VVGVFCAIINGGL---QPAFAIIFSKII 736
Query: 882 SLWT--DDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLH 939
++T DDP ++++ + ++ ALGI I F G + ++ L +
Sbjct: 737 GVFTRIDDPETK--RQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFR 794
Query: 940 SILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILL-- 995
S+LR +S+F+ + +G L R + + V I + + ++ N+ I+ +
Sbjct: 795 SMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYG 854
Query: 996 --ATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF 1053
T + I+P + + V + S + LK + + S + E + + +
Sbjct: 855 WQLTLLLLAIVPIIAIAG--VVEMKMLSGQALKDKKELEGSGKIA--TEAIENFRTVVSL 910
Query: 1054 EEQERFIHQ--SDLKV---DENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRH 1108
++++F H L+V + +KA+ I + A+ C A L A
Sbjct: 911 TQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMS 970
Query: 1109 SLSAGLVGLSVSYSL----QVTTYLNWLVRMSSEMETNIVAVER---LKEYSETEKEAPW 1161
LV +V + QV+++ + I+ +E+ + YS TE P
Sbjct: 971 FEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYS-TEGLMPN 1029
Query: 1162 QIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSS 1220
++ G V F Y D VL+ +++ + G+ + +VG +G GKS+
Sbjct: 1030 TLE-----------GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKST 1078
Query: 1221 LTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFS 1277
+ L R + G++++DG I ++ + LR + I+ Q+P+LF S+ N+ D
Sbjct: 1079 VVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR 1138
Query: 1278 QYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILV 1337
S EE+ + + A++ F+ +LP+K + + G LS GQ+Q + +ARAL+R+ IL+
Sbjct: 1139 VVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
Query: 1338 LDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPS 1397
LDEAT+A+D E++ ++Q + E T + IAHRL+TI + ++V G ++E+G
Sbjct: 1199 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1258
Query: 1398 DLLQQRGLFYSM 1409
LL Q+G+++SM
Sbjct: 1259 QLLAQKGIYFSM 1270
Score = 155 bits (392), Expect = 3e-37
Identities = 138/522 (26%), Positives = 249/522 (47%), Gaps = 36/522 (6%)
Query: 908 GISQGIAVFGYSMAVSIGGILASRCLHV---DLLHSILRSPMSFFERTPSGNLVNRFSKE 964
GI G+ V Y + VS + A R +H H+I+R + +F+ G L R + +
Sbjct: 120 GIGAGVLVAAY-IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDD 178
Query: 965 LDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVA 1020
+ ++ I + I MF S+ IV T + I P LGL + +
Sbjct: 179 VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAK--IL 236
Query: 1021 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQK-AYYPSIV 1079
SS K L + +++ + E L + + AF Q++ + + + ++E ++ +I
Sbjct: 237 SSFTDKELLAYAKAGAVA--EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT 294
Query: 1080 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVG-------LSVSYSLQVTTYLNWL 1132
AN +G +L A +A+ + + L G L+V +S+ + +
Sbjct: 295 AN-------ISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
Query: 1133 VRMSSEMETNI--VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRY--R 1188
S E N A E K + P + G +EFRN Y R
Sbjct: 348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI---KGNLEFRNVHFSYPSR 404
Query: 1189 EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGL 1248
+++ +L+ +N+ + G+ V +VG +G GKS+ + R+ + EG + +DG +I I +
Sbjct: 405 KEVK-ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
Query: 1249 HDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHE 1307
LR I ++ Q+PVLF+ ++ N+ + +E+ +++ A+ DF+ LP K D
Sbjct: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
Query: 1308 CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVL 1367
E G LS GQ+Q + +ARAL+R KIL+LDEAT+A+D E++ ++Q + + T +
Sbjct: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 583
Query: 1368 TIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1409
IAHRL+T+ + + D G I E G +L++++G+++ +
Sbjct: 584 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/77 (31%), Positives = 42/77 (54%), Gaps = 5/77 (6%)
Query: 689 SALLAEMDKVEGHVAIKTR-----ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
SAL E +KV K R I++ H +S + D+I+V G++ E G++Q+LLA+
Sbjct: 1204 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1263
Query: 744 DGAFAEFLRTYASTEQE 760
G + + A T+++
Sbjct: 1264 KGIYFSMVSVQAGTKRQ 1280
Score = 44.3 bits (103), Expect = 8e-04
Identities = 25/94 (26%), Positives = 47/94 (50%), Gaps = 1/94 (1%)
Query: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
DS + K ++ RN F++ +R + L G+ + G VA+VG GCGKS+
Sbjct: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
Query: 687 LLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
+ + D EG V++ + + T ++ +L ++
Sbjct: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
Score = 42.0 bits (97), Expect = 0.004
Identities = 65/297 (21%), Positives = 115/297 (38%), Gaps = 40/297 (13%)
Query: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV-LAGVAVMVLMVPV 479
G I + ++V Q +L T I + + Q L LL L + P + +AGV M ++
Sbjct: 827 GAIGSRLAVITQNIANLGTGIIISFIYGWQ----LTLLLLAIVPIIAIAGVVEMKML--- 879
Query: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELK-V 538
+ A+K K K + K+ E + + + E F+ Q +
Sbjct: 880 -SGQALKDK-------KELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS 931
Query: 539 LKKSAYLSAVGTFTWVCTPFLVALC-TFAVYVTIDENNILDAQTAFVSLALFNILRFPLN 597
L+K+ +FT F A C F Y+ + + S +F
Sbjct: 932 LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGA------ 985
Query: 598 ILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---------SITVRN 648
M + + + + +I +H + IE+ P+ D T ++T
Sbjct: 986 ---MAVGQVSSFAPDYAKAKISAAHIIM---IIEKTPLIDSYSTEGLMPNTLEGNVTFGE 1039
Query: 649 ATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
F + R D P L G++ + +G +A+VG GCGKS+++ L D + G V +
Sbjct: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLL 1096
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 164 bits (416), Expect = 4e-40
Identities = 182/744 (24%), Positives = 323/744 (43%), Gaps = 79/744 (10%)
Query: 706 TRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
T I V H +S + D II G E G+++ELL R G + F ++ Q E
Sbjct: 609 TIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVY--FTLVTLQSQGNQALNE 666
Query: 766 NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISR----HHNSTAELQK 821
+ + A+ G DS ++++ S SY H ST E
Sbjct: 667 EDIKDATEDDMLARTFSRGSY-QDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYE--- 722
Query: 822 AEAKKEETWKLME-ADKAQTGQV-KLSV-YWDYMK--AIGLFIS--FLSIFLFMCNHVSA 874
E +K++ + E + A ++ K S W YM ++G ++ ++ F+ + +
Sbjct: 723 -EDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILG 781
Query: 875 LASNYWLSLWTDDPIVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRC 932
S I + ++ +++ ++ A+G F A + G L ++
Sbjct: 782 TFS-----------IPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKR 830
Query: 933 LHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGAC 990
L ++L +++F+ R G L R + + V I M + S NV A
Sbjct: 831 LRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAM 890
Query: 991 IVILLATPIAAIII----PPLGLIYFFVQRFYVA-SSRQLKRLESVSRSPVYSHFNETLL 1045
I+ + +++I P L L R +SR + LE V + NE L
Sbjct: 891 IIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQIT-----NEALS 945
Query: 1046 GVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECV-------------- 1091
+ + ++ RFI + ++++ K + +C+
Sbjct: 946 NIRTVAGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGY 1005
Query: 1092 --GNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERL 1149
N + F+ +F VIS LSA +G + SY+ S + I A
Sbjct: 1006 LISNEGLHFSYVFRVISAVVLSATALGRAFSYT-------------PSYAKAKISAA--- 1049
Query: 1150 KEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF-VLRHINVTINGGEKV 1208
+ + +++ P + TA G+++F + Y D VL ++V+I+ G+ +
Sbjct: 1050 RFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTL 1109
Query: 1209 GIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGS 1268
VG +G GKS+ L R + +G+++IDG + K+ + LR I I+ Q+PVLF+ S
Sbjct: 1110 AFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACS 1169
Query: 1269 LRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL 1325
+ N+ D + E V + + A L DFV +LP+K + G LS G++Q + +
Sbjct: 1170 IMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAI 1229
Query: 1326 ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL 1385
ARA++R KIL+LDEAT+A+D E++ +Q + E T + IAHRL+TI + + V+
Sbjct: 1230 ARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRTCIVIAHRLSTIQNADIIAVM 1289
Query: 1386 DKGEIQEYGAPSDLLQQRGLFYSM 1409
+G + E G +L+ Q+G +Y +
Sbjct: 1290 AQGVVIEKGTHEELMAQKGAYYKL 1313
Score = 139 bits (350), Expect = 2e-32
Identities = 135/555 (24%), Positives = 255/555 (45%), Gaps = 40/555 (7%)
Query: 880 WLSLWTDDPIVNGTQ------EHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILASRCL 933
W + + + NGT+ E ++ + Y A GI+ + + GY + + I A+R +
Sbjct: 114 WTNSSLNQNMTNGTRCGLLNIESEMIKFASYYA-GIAVAVLITGY-IQICFWVIAAARQI 171
Query: 934 HVD---LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVI-GA 989
I+R + +F+ G L RFS +++ ++ I + + +F+ + + I G
Sbjct: 172 QKMRKFYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGF 231
Query: 990 CIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLK-RLESVSRSPVYSHFNETLLGVS 1048
+ + +II LI ++ S+ L++ +++ V + +E + +
Sbjct: 232 LLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA--DEVISSMR 289
Query: 1049 VIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGN-------CIVL--FA 1099
+ AF ++R + + + + + A RW +R V C++ +A
Sbjct: 290 TVAAFGGEKREVERYEKNL----------VFAQRW-GIRKGIVMGFFTGFVWCLIFLCYA 338
Query: 1100 ALFAVISRHSLSAG--LVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK 1157
F S L G G V L V L S +E ET
Sbjct: 339 LAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETID 398
Query: 1158 EAPWQIQETAPPSSWPQV-GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTG 1215
P + ++ G +EF N Y + +L +N+ I GE +VG +G
Sbjct: 399 RKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSG 458
Query: 1216 AGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDP 1275
AGKS+ + R + EG + +DG +I + + LR +I I+ Q+PVLFS ++ N+
Sbjct: 459 AGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRY 518
Query: 1276 FSQYSD-EEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTK 1334
+ + E++ + + A+ +F+ LP + D EGG +S GQ+Q V +ARAL+R K
Sbjct: 519 GREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPK 578
Query: 1335 ILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYG 1394
IL+LD AT+A+D E++ ++Q + T++++AHRL+T+ +I + G E G
Sbjct: 579 ILLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERG 638
Query: 1395 APSDLLQQRGLFYSM 1409
+LL+++G+++++
Sbjct: 639 THEELLERKGVYFTL 653
Score = 41.6 bits (96), Expect = 0.005
Identities = 17/49 (34%), Positives = 33/49 (67%)
Query: 705 KTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 753
+T I++ H +S + D+I VM+ G + E G+++EL+A+ GA+ + + T
Sbjct: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVTT 1316
Score = 40.0 bits (92), Expect = 0.016
Identities = 23/55 (41%), Positives = 31/55 (56%), Gaps = 1/55 (1%)
Query: 651 FTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAI 704
FT+ +R D LNG++ SI G +A VG GCGKS+ + L D +G V I
Sbjct: 1085 FTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMI 1139
Score = 36.2 bits (82), Expect = 0.23
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 628 DSIERRPVKDGGGTNS---------ITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVV 677
++I+R+P+ D + I N TF + +R + LN + I G + A+V
Sbjct: 395 ETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALV 454
Query: 678 GQVGCGKSSLLSALLAEMDKVEGHVAI 704
G G GKS+ L + D EG V +
Sbjct: 455 GPSGAGKSTALQLIQRFYDPCEGMVTV 481
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 937 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 997 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1053
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1054 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1109
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1110 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1169
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1170 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1228
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1229 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1282
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1403 RGLFYSMAK 1411
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 43.9 bits (102), Expect = 0.001
Identities = 70/345 (20%), Positives = 147/345 (42%), Gaps = 37/345 (10%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
+VG G GKSS ++ L G V + + + + YL +V
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
Score = 40.0 bits (92), Expect = 0.016
Identities = 19/69 (27%), Positives = 42/69 (60%), Gaps = 5/69 (7%)
Query: 689 SALLAEMD-----KVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
SAL AE + + G++ T +++ H +S + +I+V+ G++ + G++Q+LLA+
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 744 DGAFAEFLR 752
G +A+ ++
Sbjct: 731 GGLYAKLVQ 739
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 162 bits (409), Expect = 3e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 937 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
Query: 997 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1053
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
Query: 1054 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1109
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
Query: 1110 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1169
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
Query: 1170 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1228
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
Query: 1229 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1282
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
Query: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
Query: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 1403 RGLFYSMAK 1411
GL+ + +
Sbjct: 731 GGLYAKLVQ 739
Score = 43.9 bits (102), Expect = 0.001
Identities = 70/345 (20%), Positives = 147/345 (42%), Gaps = 37/345 (10%)
Query: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
Query: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
Query: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
Query: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
Query: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT--LNGITFSIPEGALVA 675
L PD +E R + N TFT+ R+ P T L ++FS+ G + A
Sbjct: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTA 536
Query: 676 VVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
+VG G GKSS ++ L G V + + + + YL +V
Sbjct: 537 LVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
Score = 40.0 bits (92), Expect = 0.016
Identities = 19/69 (27%), Positives = 42/69 (60%), Gaps = 5/69 (7%)
Query: 689 SALLAEMD-----KVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
SAL AE + + G++ T +++ H +S + +I+V+ G++ + G++Q+LLA+
Sbjct: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
Query: 744 DGAFAEFLR 752
G +A+ ++
Sbjct: 731 GGLYAKLVQ 739
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 155 bits (393), Expect = 2e-37
Identities = 138/532 (25%), Positives = 246/532 (46%), Gaps = 35/532 (6%)
Query: 901 LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNR 960
L +YG QG+ FGY + +S G + + L S+LR ++FF+ +G LV+R
Sbjct: 182 LILYGV----QGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSR 237
Query: 961 FSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVA 1020
+ ++ S VI + S V G + + + + +++ V +
Sbjct: 238 LTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTLMGS 297
Query: 1021 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA 1080
R+L R + +E L V +RAF ++R ++ Y + A
Sbjct: 298 GLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQR-----------EEERYGAELEA 346
Query: 1081 NRWLAVRL-----------ECVGNCIVLFAALF---AVISRHSLSAGLVGLSVSYSLQVT 1126
R A L NC+VL LF ++++ L+ G + + S V
Sbjct: 347 CRCRAEELGRGIALFQGLSNIAFNCMVL-GTLFIGGSLVAGQQLTGGDLMSFLVASQTVQ 405
Query: 1127 TYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLR 1186
+ L + ++ + A R+ EY P P G V F+N C
Sbjct: 406 RSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR--GSVTFQNVCFS 463
Query: 1187 YREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAK 1245
Y F VL+ +T+ G+ V +VG++G GK+++ L R + G +++DG ++
Sbjct: 464 YPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRT 523
Query: 1246 IGLHDLRFKIT-IIPQDPVLFSGSLRMNLDPFS-QYSDEEVWTSLELAHLKDFVSALPDK 1303
+ LR ++ I Q+PVLF ++ N+ + SDEEV+T+ A+ +F+++ P+
Sbjct: 524 LDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREANAHEFITSFPEG 583
Query: 1304 LDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1363
+ E G LS GQ+Q + +ARAL+++ +L+LDEAT+A+D E++ ++Q +
Sbjct: 584 YNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
Query: 1364 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGL 1415
TVL IAHRL+T+ ++V+ G + E G +LL++ GL+ + + L
Sbjct: 644 RTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQAL 695
Score = 42.4 bits (98), Expect = 0.003
Identities = 24/72 (33%), Positives = 42/72 (58%), Gaps = 5/72 (6%)
Query: 689 SALLAEMDKVEGHV-----AIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
SAL AE ++V A +T +++ H +S + I+VM+ G++ E G+++ELL +
Sbjct: 623 SALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKK 682
Query: 744 DGAFAEFLRTYA 755
G +AE +R A
Sbjct: 683 GGLYAELIRRQA 694
Score = 41.2 bits (95), Expect = 0.007
Identities = 27/76 (35%), Positives = 40/76 (52%), Gaps = 1/76 (1%)
Query: 643 SITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGH 701
S+T +N F++ R L T ++P G +VA+VGQ G GK+++ S L D G
Sbjct: 454 SVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGV 513
Query: 702 VAIKTRILVTHSMSYL 717
V + R L T S+L
Sbjct: 514 VMLDGRDLRTLDPSWL 529
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B isoform
1 [Homo sapiens]
Length = 703
Score = 154 bits (389), Expect = 6e-37
Identities = 119/466 (25%), Positives = 233/466 (50%), Gaps = 22/466 (4%)
Query: 937 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996
L S+LR + FF+ T +G L +R S + + + +P + + SL V+G +L
Sbjct: 229 LFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSI 288
Query: 997 TPIAAIIIPPLGLIY--FFVQRFYVASSRQLKRLESVSRSPVYSH--FNETLLGVSVIRA 1052
+P + L L++ F + V ++R + L + + + E + G+ +R+
Sbjct: 289 SPRLTL----LSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRS 344
Query: 1053 FEEQERFIHQSDLKVDENQKAYYPSIV--ANRWLAVRLECVGNCIVLFAALFAVISRHSL 1110
F +E + + +++ ++ Y+ + A L R+ +G +++ + + L
Sbjct: 345 FGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGEL 404
Query: 1111 SAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPS 1170
+ G + + Y V +Y+ LV + +M +N+ A E++ Y + + P +P +
Sbjct: 405 TQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLP------SPGT 458
Query: 1171 SWPQV--GRVEFRNYCLRYREDLDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFR 1227
P G V+F++ Y D VL+ + T+ GE +VG G+GKS++ L
Sbjct: 459 LAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 518
Query: 1228 INESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWT 1286
+ + G++++D I++ L ++ + Q+PVLFSGS+R N+ D++V
Sbjct: 519 LYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMA 578
Query: 1287 SLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVD 1346
+ + AH DF+ + + + E G L+ GQ+Q + +ARAL+R ++L+LDEAT+A+D
Sbjct: 579 AAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD 638
Query: 1347 LETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQE 1392
++ + +Q D TVL IAHRL + +++VL +G++Q+
Sbjct: 639 VQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
Score = 37.7 bits (86), Expect = 0.079
Identities = 20/63 (31%), Positives = 32/63 (50%)
Query: 655 RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSM 714
R D P L G+TF++ G + A+VG G GKS++ + L G V + + + +
Sbjct: 480 RPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEH 539
Query: 715 SYL 717
YL
Sbjct: 540 CYL 542
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,091,479
Number of Sequences: 37866
Number of extensions: 2057599
Number of successful extensions: 6004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 5514
Number of HSP's gapped (non-prelim): 343
length of query: 1416
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1301
effective length of database: 13,892,928
effective search space: 18074699328
effective search space used: 18074699328
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.