Search of human proteins with 55749708

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|55749708 outer dense fiber of sperm tails 2-like isoform b
[Homo sapiens]
         (513 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|55749708 outer dense fiber of sperm tails 2-like isoform b [H...   996   0.0  
gi|55749696 outer dense fiber of sperm tails 2-like isoform a [H...   996   0.0  
gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo s...   264   2e-70
gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo s...   162   7e-40
gi|55770834 centromere protein F [Homo sapiens]                       105   1e-22
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   100   3e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    99   9e-21
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    96   6e-20
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    96   8e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    96   8e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    96   8e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    96   8e-20
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    96   1e-19
gi|4758650 kinesin family member 5C [Homo sapiens]                     94   2e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             94   2e-19
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    94   3e-19
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]     92   1e-18
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap...    92   1e-18
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    92   1e-18
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     92   1e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    91   2e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    91   3e-18
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    90   6e-18
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...    89   7e-18
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     88   2e-17
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              88   2e-17
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    87   4e-17
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    87   5e-17
gi|42794779 myosin 18A isoform b [Homo sapiens]                        87   5e-17
gi|28416946 myosin 18A isoform a [Homo sapiens]                        87   5e-17

>gi|55749708 outer dense fiber of sperm tails 2-like isoform b [Homo
           sapiens]
          Length = 513

 Score =  996 bits (2576), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60
           MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI
Sbjct: 1   MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60

Query: 61  QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
           QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ
Sbjct: 61  QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120

Query: 121 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
           RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN
Sbjct: 121 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180

Query: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
           LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE
Sbjct: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240

Query: 241 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300
           LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES
Sbjct: 241 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300

Query: 301 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
           HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE
Sbjct: 301 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360

Query: 361 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
           EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE
Sbjct: 361 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420

Query: 421 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 480
           AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL
Sbjct: 421 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 480

Query: 481 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
           KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE
Sbjct: 481 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513


>gi|55749696 outer dense fiber of sperm tails 2-like isoform a [Homo
           sapiens]
          Length = 644

 Score =  996 bits (2576), Expect = 0.0
 Identities = 513/513 (100%), Positives = 513/513 (100%)

Query: 1   MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60
           MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI
Sbjct: 132 MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 191

Query: 61  QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
           QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ
Sbjct: 192 QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 251

Query: 121 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
           RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN
Sbjct: 252 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 311

Query: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
           LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE
Sbjct: 312 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 371

Query: 241 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300
           LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES
Sbjct: 372 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 431

Query: 301 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
           HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE
Sbjct: 432 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 491

Query: 361 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
           EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE
Sbjct: 492 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 551

Query: 421 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 480
           AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL
Sbjct: 552 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 611

Query: 481 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
           KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE
Sbjct: 612 KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 644



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 66/348 (18%), Positives = 153/348 (43%), Gaps = 33/348 (9%)

Query: 183 EDLKKMEDHGKNSC--EEILRKVHSIEYENETLNLENTKLKTTLAALKD--EVVSVEN-- 236
           EDL +       SC  ++IL +   +E   +   L    ++  L   KD  E ++ EN  
Sbjct: 25  EDLPRCTSESHLSCLKQDILNEKTELEATLKEAELVTHSVELLLPLFKDTIEKINFENAN 84

Query: 237 ------ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKS--RCENLLHKNNQITKTKN 288
                 ++SE +E+  K+    +  K  ++ L    +  ++     ++L +N    +++N
Sbjct: 85  LSALNLKISEQKEILIKELDTFKSVKLALEHLLRKRDYKQTGDNLSSMLLENLTDNESEN 144

Query: 289 KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 348
            N++K   + E+H++EL  +  S  A   + +   +S++    +   Q H  RE +    
Sbjct: 145 TNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHK-REAEND-- 201

Query: 349 GNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEE--CLKHSNLKFK 406
                  KL    ++   ++   NLQ ++     +N+ +  K A++++   LK ++  +K
Sbjct: 202 -------KLKEYVKSLETKIAKWNLQSRMN----KNEAIVMKEASRQKTVALKKASKVYK 250

Query: 407 EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES---ALQIKILDLETELRKKNEEQN 463
           ++   +T    +L + + +   K++E I   ++ +S    + I+  +LE ++    ++  
Sbjct: 251 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQII 310

Query: 464 QLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
            L+  +     H +   +E+   +   E +NE++      LKT+   +
Sbjct: 311 NLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAAL 358


>gi|24430181 outer dense fiber of sperm tails 2 isoform 1 [Homo
           sapiens]
          Length = 805

 Score =  264 bits (674), Expect = 2e-70
 Identities = 156/516 (30%), Positives = 286/516 (55%), Gaps = 5/516 (0%)

Query: 2   LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
           LL+ L + +SE   L   + +K+  ++EL    Q EKA    A+  S+S++ +   LQ Q
Sbjct: 269 LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ 328

Query: 62  IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR 121
           +  +EAEN +L   +K+LE    +   +      +   +K+   +   +LKKA +  K+R
Sbjct: 329 LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKER 388

Query: 122 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
            +      E+L  Q+ D++  ++E +S   +W+S Y ++V EK +LE++I  +  ++ +L
Sbjct: 389 AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDL 448

Query: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
           +   + +E+  +   + ++ ++H    E     LEN +LK + A ++D++     E+ +L
Sbjct: 449 VNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 508

Query: 242 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
           +   K  + +I+ YK+QV K +  A+ V ++ E    +N  +    NK +E  R Q +S 
Sbjct: 509 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 568

Query: 302 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL---- 357
           L +L+++ D L   E +L ECQ+ LQ  + K  D    I +L+ +++   + L       
Sbjct: 569 LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKH 628

Query: 358 -SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALA 416
            + ++EN  + LK + L++KLE   A+N E  + +A +EE +  S L+ +EK+ E   LA
Sbjct: 629 QASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLA 688

Query: 417 RQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQ 476
           RQLE+A+E+ R++V +  E   S+E A Q KILDLET+L +   E +QL    +   +  
Sbjct: 689 RQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRY 748

Query: 477 EVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMF 512
           +  L+++++ LE+SE+ N S++NY+QFLK+SY  +F
Sbjct: 749 QSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVF 784



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 108/502 (21%), Positives = 196/502 (39%), Gaps = 69/502 (13%)

Query: 62  IHKREAENDKLKEYVKSLETKIAKWNLQS--RMNKNEAIVMKEASRQKTVALKKASKVYK 119
           +H    EN  +  ++K L    A  + +S  R  K + + ++ + R KT       K   
Sbjct: 10  LHVHVDENTPVHVHIKKLPKPSATSSQKSHKRGMKGDTVNVRRSVRVKT-------KNPP 62

Query: 120 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKI-----VIEKTELEVQIETM 174
             L+    + EKL S +R  +    +  S       + +KI      +   + EV+++  
Sbjct: 63  HCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKG 122

Query: 175 KKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETL--NLENTKLKTTLAALKDEVV 232
           ++Q+       K+  +  K   EE+  ++   E+EN  L  N+E  K +     L+ + +
Sbjct: 123 ERQMA------KRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHL 176

Query: 233 SVENE--LSELQEVEK-----------------KQKTLIEMYKTQVQKLQEAAEIVKSRC 273
             E E  +S+L E E                  K KT  +M  T +  L    E++  + 
Sbjct: 177 QQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKL 236

Query: 274 ENLLHKN--------NQITKTKNKNVEKMRGQMESHLKELE----RVCDSLTAAERRLHE 321
                 N         Q  K  ++ + + +G +   L E +    R+   L   ++ + E
Sbjct: 237 STFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEE 296

Query: 322 CQESLQCCKGKCADQEHTIRELQGQVDG--NHNLLTKLSLEEENCLIQLKCENLQQKLEQ 379
             + +QC K     Q  T  EL   ++    H      S E EN  + ++ +NL++   Q
Sbjct: 297 LLQEIQCEKA----QAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQ 352

Query: 380 MDAE-------NKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 432
             AE        KEL++K    +E LK +    KE++ +    A QL   L +    VAE
Sbjct: 353 HKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAE 412

Query: 433 ---EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 489
               +E   SR + +  +  DLE E+   N+    LV +  +  +        +   L +
Sbjct: 413 ALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHR 472

Query: 490 SENQNESIKNYLQFLKTSYVTM 511
              +  + K   + LK S+  M
Sbjct: 473 QTAEYSAFKLENERLKASFAPM 494


>gi|24430183 outer dense fiber of sperm tails 2 isoform 2 [Homo
           sapiens]
          Length = 638

 Score =  162 bits (410), Expect = 7e-40
 Identities = 98/356 (27%), Positives = 186/356 (52%), Gaps = 4/356 (1%)

Query: 2   LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
           LL+ L + +SE   L   + +K+  ++EL    Q EKA    A+  S+S++ +   LQ Q
Sbjct: 274 LLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQ 333

Query: 62  IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR 121
           +  +EAEN +L   +K+LE    +   +      +   +K+   +   +LKKA +  K+R
Sbjct: 334 LRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKER 393

Query: 122 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
            +      E+L  Q+ D++  ++E +S   +W+S Y ++V EK +LE++I  +  ++ +L
Sbjct: 394 AEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDL 453

Query: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
           +   + +E+  +   + ++ ++H    E     LEN +LK + A ++D++     E+ +L
Sbjct: 454 VNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQL 513

Query: 242 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
           +   K  + +I+ YK+QV K +  A+ V ++ E    +N  +    NK +E  R Q +S 
Sbjct: 514 KASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQ 573

Query: 302 LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV----DGNHNL 353
           L +L+++ D L   E +L ECQ+ LQ  + K  D    I +L+ +V     G+H L
Sbjct: 574 LADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHEL 629



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 92/415 (22%), Positives = 174/415 (41%), Gaps = 40/415 (9%)

Query: 118 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 177
           Y +++D    A+  L S+++ Q+ +           K   E++  E  E E +   ++  
Sbjct: 104 YDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHN 163

Query: 178 IINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENE 237
           I    E +K+ +D        IL+K H ++ E E L  +  + +   AA   +V+++++ 
Sbjct: 164 I----ERMKEEKDF------TILQKKH-LQQEKECLMSKLVEAEMDGAAAAKQVMALKDT 212

Query: 238 LSELQEVEKKQ-----KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 292
           + +L+  EK+       TL    +  +QKL    E  ++  + L     Q  K  ++ + 
Sbjct: 213 IGKLK-TEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLL---REQHCKEDSERLM 268

Query: 293 KMRGQMESHLKELE----RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 348
           + +G +   L E +    R+   L   ++ + E  + +QC K     Q  T  EL   ++
Sbjct: 269 EQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKA----QAKTASELSKSME 324

Query: 349 G--NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAEN-------KELEKKLANQEECLK 399
               H      S E EN  + ++ +NL++   Q  AE        KEL++K    +E LK
Sbjct: 325 SMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLK 384

Query: 400 HSNLKFKEKSAEYTALARQLEAALEEGRQKVAE---EIEKMSSRESALQIKILDLETELR 456
            +    KE++ +    A QL   L +    VAE    +E   SR + +  +  DLE E+ 
Sbjct: 385 KAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEII 444

Query: 457 KKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
             N+    LV +  +  +        +   L +   +  + K   + LK S+  M
Sbjct: 445 VLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPM 499



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 84/460 (18%), Positives = 185/460 (40%), Gaps = 44/460 (9%)

Query: 6   LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR 65
           L + E ENT L+  +              + EK  T+   +  Q  K   E L  ++ + 
Sbjct: 150 LAETEHENTVLRHNIER-----------MKEEKDFTILQKKHLQQEK---ECLMSKLVEA 195

Query: 66  EAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHF 125
           E +     + V +L+  I K   + +M   +   +   +RQK + L        Q+L  F
Sbjct: 196 EMDGAAAAKQVMALKDTIGKLKTEKQMTCTD---INTLTRQKELLL--------QKLSTF 244

Query: 126 TGAIEKLTSQIRDQEAK--LSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 183
                 L   +R+Q  K      +    A      +   EK  L + ++   K++  LL+
Sbjct: 245 EETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQ 304

Query: 184 DLKKMEDHGKNSCE----------EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVS 233
           +++  +   K + E           +  ++ S E EN  L ++   L+ +    K EV +
Sbjct: 305 EIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEA 364

Query: 234 VENELSEL-QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 292
           +  +L EL Q+ ++ +++L +  + Q ++ +++ E  +     L  K+  + +  +  +E
Sbjct: 365 IMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALS-TLE 423

Query: 293 KMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHN 352
             R +    +KE   +   +     R+ +     Q  + K  +   ++ E   +    ++
Sbjct: 424 SWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYS 483

Query: 353 LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEY 412
                + + EN  ++     ++ KL Q   E ++L+  + N E  + +   +  +   E 
Sbjct: 484 -----AFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEA 538

Query: 413 TALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLE 452
             +A QLE   +E +    E  +++ +     Q ++ DL+
Sbjct: 539 DEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQ 578


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  105 bits (261), Expect = 1e-22
 Identities = 127/550 (23%), Positives = 248/550 (45%), Gaps = 77/550 (14%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKV---VHERL 58
            L   L++++ E  N+ K +        E +    S +    +  R  + ++V     E+ 
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKK 2134

Query: 59   QIQI----HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALK-- 112
            Q+ I     +RE END LK+ V++LE ++      S  N+   I+  E S+ +   LK  
Sbjct: 2135 QLHIAEKLKERERENDSLKDKVENLERELQ----MSEENQELVILDAENSKAEVETLKTQ 2190

Query: 113  -----KASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTEL 167
                 ++ KV++  L       E LT QI++++ +LSE     +++KS  E    EK + 
Sbjct: 2191 IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE----EKEQA 2246

Query: 168  EVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAAL 227
            E+QI+   K  + +L+          N  +E+   V ++  + E +      L   +   
Sbjct: 2247 EIQIKEESKTAVEMLQ----------NQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296

Query: 228  KDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTK 287
                 S+E   + L+  EKKQ  +++    Q+++ +  A+++K R EN L +  +I +T 
Sbjct: 2297 HQLRNSIEKLRARLEADEKKQLCVLQ----QLKESEHHADLLKGRVEN-LERELEIARTN 2351

Query: 288  NKN----VEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIREL 343
             ++     E  +G++E+   ++E +  SL   E  +   +   +    +   ++  I EL
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISEL 2411

Query: 344  QGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLA----NQEECLK 399
            +       N+L     E+E   +Q+K E     +E +  + KEL +++A    +QE C  
Sbjct: 2412 EIINSSFENILQ----EKEQEKVQMK-EKSSTAMEMLQTQLKELNERVAALHNDQEAC-- 2464

Query: 400  HSNLKFKEKSAEYTALARQLE-AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKK 458
                K KE++        +LE A L +G  +       + S  + L  ++ D + +L KK
Sbjct: 2465 ----KAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKK 2520

Query: 459  NEE----------QNQLVCKMNS--------KAQHQEV--CLKEVQNSLEKSENQNESIK 498
            +EE          Q QLV K++         K Q+ E+     E++  ++  +++N S++
Sbjct: 2521 DEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQ 2580

Query: 499  NYLQFLKTSY 508
            + L+ L++SY
Sbjct: 2581 DTLEVLQSSY 2590



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 122/521 (23%), Positives = 221/521 (42%), Gaps = 88/521 (16%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
           +++N  L+ K+ E E  +Q        EK    + N+F +        LQ+Q+ K + E 
Sbjct: 284 KAQNQELRNKINELELRLQG------HEKEMKGQVNKFQE--------LQLQLEKAKVEL 329

Query: 70  DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAI 129
            + ++ +     ++ +   Q     ++A     A  QK   LKK ++    +  +   A 
Sbjct: 330 IEKEKVLNKCRDELVRTTAQY----DQASTKYTALEQK---LKKLTEDLSCQRQNAESAR 382

Query: 130 EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKME 189
             L  +I+++E +  E +S         ++  I+          MK ++   L+  K M 
Sbjct: 383 CSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ----------MKARLTQELQQAKNMH 432

Query: 190 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSV-ENELSELQEVEKKQ 248
               N  +  L K+ S++ + E  NLE  K K   A    +   + ENEL    E  KK+
Sbjct: 433 ----NVLQAELDKLTSVKQQLEN-NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487

Query: 249 KTLIEMYKTQ----VQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE 304
             L++ +  Q    V  L+   + +K +C N      +  K KN + E M   ++  + +
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIK-QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546

Query: 305 LERVCDSLTAAERRLH--ECQESLQCCKGKCADQEHTIRELQGQVDGNHN----LLTKLS 358
            E   +SLT  + +L   + ++   C +     +EH I +L  ++         LL+ L 
Sbjct: 547 QE---NSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603

Query: 359 L---------EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 409
           L         EE+      K EN ++ L QM++E + L+ K+ + E CLK   +    KS
Sbjct: 604 LKKKEYEELKEEKTLFSCWKSEN-EKLLTQMESEKENLQSKINHLETCLKTQQI----KS 658

Query: 410 AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLET------ELRKKNEEQN 463
            EY    R     LE  R+ ++ EI  +    + L  K +++ET      EL++K E  +
Sbjct: 659 HEYNERVR----TLEMDRENLSVEIRNL---HNVLDSKSVEVETQKLAYMELQQKAEFSD 711

Query: 464 QLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFL 504
           Q       + + + +CLK  Q +      Q E +++ LQ L
Sbjct: 712 Q-----KHQKEIENMCLKTSQLT-----GQVEDLEHKLQLL 742



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 123/605 (20%), Positives = 230/605 (38%), Gaps = 154/605 (25%)

Query: 5    NLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANR----FSQSVKVVHERLQI 60
            +L    SE  NL K++ EK+  + EL  L  S K+   +  +      +  K   E LQ 
Sbjct: 2204 DLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQN 2263

Query: 61   QIHKRE-------AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKK 113
            Q+ +          + + +K   +SL+  I + + Q R +  +     EA  +K + + +
Sbjct: 2264 QLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH-QLRNSIEKLRARLEADEKKQLCVLQ 2322

Query: 114  ASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIET 173
              K  +   D   G +E L     ++E +++ T         + E   +E    + ++ET
Sbjct: 2323 QLKESEHHADLLKGRVENL-----ERELEIART---------NQEHAALEAENSKGEVET 2368

Query: 174  MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVS 233
            +K +I  + + L+ +E             V +I  E E L  E  K +  ++ L+    S
Sbjct: 2369 LKAKIEGMTQSLRGLE-----------LDVVTIRSEKENLTNELQKEQERISELEIINSS 2417

Query: 234  VENELSELQE----VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 289
             EN L E ++    +++K  T +EM +TQ+++L E            LH + +  K K +
Sbjct: 2418 FENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA--------LHNDQEACKAKEQ 2469

Query: 290  NV-------EKMRGQMESHLKELER-----------VCDSLTAAERRLHECQESLQCCKG 331
            N+       E  + Q+   L E +            +   +   +++L +  E +   K 
Sbjct: 2470 NLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKN 2529

Query: 332  KCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELE--- 388
            +  DQE  + +L  QV+G H L  + +LE  N  ++L     +QK++ + ++N  L+   
Sbjct: 2530 QIQDQEQLVSKLS-QVEGEHQLWKEQNLELRNLTVEL-----EQKIQVLQSKNASLQDTL 2583

Query: 389  -------KKLANQEECLKHSNLKFKEK-----------------------------SAEY 412
                   K L N+ E  K   + F EK                             S E 
Sbjct: 2584 EVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643

Query: 413  TALARQLEAALEE-----------------------------------GRQKVAEEIEKM 437
              LA +L+  LEE                                    R+++AE   ++
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL 2703

Query: 438  SSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 497
               E   Q  +LD        N++    +     K   +E CL   +  ++  ++  E +
Sbjct: 2704 HEAEKKHQALLLD-------TNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEEL 2756

Query: 498  KNYLQ 502
             N L+
Sbjct: 2757 NNSLK 2761



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 88/402 (21%), Positives = 178/402 (44%), Gaps = 44/402 (10%)

Query: 61   QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEAS---RQKTVALKKASKV 117
            ++ K++ E  +LK  ++  E  ++K +      + E  + KE +   R  TV L++  +V
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLS----QVEGEHQLWKEQNLELRNLTVELEQKIQV 2571

Query: 118  YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 177
             + +       +E L S  ++ E +L  T     ++     K+  ++TEL+ ++  M ++
Sbjct: 2572 LQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQK 2631

Query: 178  IINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENE 237
               L E+L   ++      + +L ++ S + + + L LEN++LK +L  +  + V  E +
Sbjct: 2632 TAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK 2691

Query: 238  LSE--------LQEVEKK-QKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN 288
            + E        L E EKK Q  L++  K    ++Q   E + S+ E L  +  +I   K+
Sbjct: 2692 VREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKS 2751

Query: 289  KNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVD 348
                             E + +SL A  + L E +++    K       + +++   +  
Sbjct: 2752 SK---------------EELNNSLKATTQILEELKKT----KMDNLKYVNQLKKENERAQ 2792

Query: 349  GNHNLLTK--LSLEEENCLIQLKCENLQQKLEQ------MDAENKELEKKLANQEECLKH 400
            G   LL K    LEEE  ++Q +   LQ   E+      MD +  EL  ++   +E L+ 
Sbjct: 2793 GKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEE 2852

Query: 401  SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 442
               +  E   +Y +L    E  LE+ ++ +  ++  + S++S
Sbjct: 2853 KTKEADEYLDKYCSLLISHE-KLEKAKEMLETQVAHLCSQQS 2893



 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 102/487 (20%), Positives = 214/487 (43%), Gaps = 53/487 (10%)

Query: 40  NTLKANRFSQSVKVVHERLQIQIHKR---EAEN--DKLKEYVKSLETKIAKWNLQSRMNK 94
           N LK++   ++ +V H   +++  K+   +++N  +++K    S ET +   +LQ ++N+
Sbjct: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR--DLQEKINQ 546

Query: 95  NEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWK 154
            E  +  E  +     L+K     +  L      IE+L  ++   E +    +SA    K
Sbjct: 547 QENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKK 606

Query: 155 SHYEKIVIEKT----------ELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH 204
             YE++  EKT          +L  Q+E+ K+ + + +  L+      +    E   +V 
Sbjct: 607 KEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVR 666

Query: 205 SIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQE 264
           ++E + E L++E   L   L +   + V VE +     E+++K +   + ++ +++ +  
Sbjct: 667 TLEMDRENLSVEIRNLHNVLDS---KSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCL 723

Query: 265 AAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRL---HE 321
               +  + E+L HK   ++   N+ ++K R   + H  E E + D L + +  L    +
Sbjct: 724 KTSQLTGQVEDLEHKLQLLS---NEIMDKDRCYQDLHA-EYESLRDLLKSKDASLVTNED 779

Query: 322 CQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE-----NCLIQLKCENLQQK 376
            Q SL     + A   H+   + G+     +  ++  LE +     + ++Q + ++L+  
Sbjct: 780 HQRSLLAFDQQPA-MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFS 838

Query: 377 LEQMDAENKELEKK---LANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG----RQK 429
           LE     N +L+K+   L   +  ++ + +K ++    + A   Q  + L+E     +  
Sbjct: 839 LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV 898

Query: 430 VAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQ----- 484
           VAE +  + ++E  LQ+        L  K E +   + ++       E  LKE+Q     
Sbjct: 899 VAETLSALENKEKELQL--------LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSET 950

Query: 485 NSLEKSE 491
            SLEK E
Sbjct: 951 LSLEKKE 957



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 100/553 (18%), Positives = 235/553 (42%), Gaps = 78/553 (14%)

Query: 3   LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEK----------ANTLKANR----FS 48
           L+ + + E +   LKK+  +++  +  L    Q +K           N  + N+      
Sbjct: 17  LQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEIC 76

Query: 49  QSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKT 108
           +S++   +++  ++  +E++ +  +  + S + +I K   + +  K+E    ++A++   
Sbjct: 77  ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136

Query: 109 VALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELE 168
           V+L   +   K      T +     S+  D + K ++ +      ++  + +  +K    
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196

Query: 169 VQIETMKKQIINLLE--------DLKKMEDH-GKNSCEEILRKVHSIEY---------EN 210
           +   TM  + I   +          +K   H   NS    +R+  S  Y           
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256

Query: 211 ETLNL----------ENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLIEMYKTQV 259
            TL +          +N+     L  LK +   + N+++EL+  ++  +K +    K QV
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM----KGQV 312

Query: 260 QKLQEAA-EIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERR 318
            K QE   ++ K++ E +          K K + K R ++     + ++     TA E++
Sbjct: 313 NKFQELQLQLEKAKVELI---------EKEKVLNKCRDELVRTTAQYDQASTKYTALEQK 363

Query: 319 LHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLE 378
           L +  E L C +        ++ +                ++E+    Q +    Q+  +
Sbjct: 364 LKKLTEDLSCQRQNAESARCSLEQ---------------KIKEKEKEFQEELSRQQRSFQ 408

Query: 379 QMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKV--AEEIEK 436
            +D E  +++ +L  + +  K+ +   + +  + T++ +QLE  LEE +QK+  AE+  +
Sbjct: 409 TLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQ 468

Query: 437 MSS-RESALQIKILDLETE---LRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSEN 492
            S  +E+ L+  + +++ E   L+  +E++ + VC + ++ ++ + CL + QN  E+ + 
Sbjct: 469 ASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKA 528

Query: 493 QNESIKNYLQFLK 505
           +N S +  L+ L+
Sbjct: 529 KNTSQETMLRDLQ 541



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 102/511 (19%), Positives = 218/511 (42%), Gaps = 62/511 (12%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
            +S +TN +    +K     E          N L    F  + + +H  LQ+++ +   EN
Sbjct: 1725 QSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHN-LQLRVKETSNEN 1783

Query: 70   DKLKEYVKSLETKIAKW-----NLQSRMNKNEAIVMKEASR----QKTVA-LKKASKVYK 119
             +L   ++  + K+         L S+++  E  +M +       +K V  LKK +    
Sbjct: 1784 LRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLS 1843

Query: 120  QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQII 179
            ++L++F+   ++L  ++   E   S+     +A KS  E I     ++    ++ K++ +
Sbjct: 1844 EKLEYFSCDHQELLQRVETSEGLNSDL--EMHADKSSREDIGDNVAKVN---DSWKERFL 1898

Query: 180  NLLEDLKKMEDHGKNSCEEIL---RKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            ++  +L ++     +   E L     +  ++ E   L  +N   +  +  L++E+  V +
Sbjct: 1899 DVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTS 1958

Query: 237  ELSELQ---EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEK 293
            E ++L+   +   K+ T ++    ++++  +  E  +S C + +       K K + ++ 
Sbjct: 1959 ERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQT 2018

Query: 294  MRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNL 353
            +   +   LK+   + + L + E+      +S      KC        EL+ Q+      
Sbjct: 2019 LSSDVSELLKDKTHLQEKLQSLEK------DSQALSLTKC--------ELENQI------ 2058

Query: 354  LTKLSLEEENCLIQLKCENLQQKLEQMDAE----NKELEKKLANQEECLKHSNLKFKEKS 409
                 L +E  L+  + E+LQ +L + D E    +K LE  L  + E      L+     
Sbjct: 2059 ---AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA----LRLSSTQ 2111

Query: 410  AEYTALARQLE------AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQN 463
             E   L R +E       A E+ +  +AE++++      +L+ K+ +LE EL+   E Q 
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQE 2171

Query: 464  QLVCKM-NSKAQHQ--EVCLKEVQNSLEKSE 491
             ++    NSKA+ +  +  ++E+  SL+  E
Sbjct: 2172 LVILDAENSKAEVETLKTQIEEMARSLKVFE 2202



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 108/548 (19%), Positives = 216/548 (39%), Gaps = 111/548 (20%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ-IHK-REA 67
           ES   +L++K+ EKE   QE     Q     TL         ++  E  Q + +H   +A
Sbjct: 379 ESARCSLEQKIKEKEKEFQE-ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQA 437

Query: 68  ENDKLKEYVKSLETKIAKWNLQ----------SRMNKNEAIVMKEASRQKTVALKKASKV 117
           E DKL    + LE  + ++  +          S++ +NE     E  +++   LK  S+ 
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497

Query: 118 YKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 177
             + + H    ++ +  Q  +Q    +E + A N  +    + + EK   +    T++K 
Sbjct: 498 KAREVCHLEAELKNI-KQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556

Query: 178 IINLLEDLKKMEDHGKNSCEEILRK-VHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            +  + DL+K  D      +++L+K  H IE  N+ L+    + K  L+AL       E 
Sbjct: 557 KL-AVADLEKQRD----CSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL-------EL 604

Query: 237 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLL--------------HKNNQ 282
           +  E +E+ K++KTL   +K++ +KL    E  K   ++ +              H+ N+
Sbjct: 605 KKKEYEEL-KEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNE 663

Query: 283 ITKT-------------------KNKNVE-------------KMRGQMESHLKELERVCD 310
             +T                    +K+VE             K     + H KE+E +C 
Sbjct: 664 RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCL 723

Query: 311 SLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKC 370
             +    ++ + +  LQ    +  D++   ++L  +                        
Sbjct: 724 KTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEY----------------------- 760

Query: 371 ENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL--EAALEEGRQ 428
           E+L+  L+  DA        + N++   + S L F ++ A + + A  +  + ++   R 
Sbjct: 761 ESLRDLLKSKDA------SLVTNEDH--QRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812

Query: 429 KVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLE 488
           +   E ++     + LQ ++  LE  L    E Q Q+   +  + +       E++ +L 
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSL----ESQKQMNSDLQKQCEELVQIKGEIEENLM 868

Query: 489 KSENQNES 496
           K+E  ++S
Sbjct: 869 KAEQMHQS 876



 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 113/567 (19%), Positives = 229/567 (40%), Gaps = 93/567 (16%)

Query: 6    LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVH-ERLQIQIHK 64
            LT  ESE  NL+ K+   E      +CL    K   +K++ +++ V+ +  +R  + +  
Sbjct: 630  LTQMESEKENLQSKINHLE------TCL----KTQQIKSHEYNERVRTLEMDRENLSVEI 679

Query: 65   REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDH 124
            R   N    + V+    K+A   LQ +   ++    KE         +   +V  + L+H
Sbjct: 680  RNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQV--EDLEH 737

Query: 125  FTGAIEKLTSQIRDQEAKL----SETISASNAWKSHYEKIVIEKTELEV-----QIETMK 175
                ++ L+++I D++       +E  S  +  KS    +V  +          Q   M 
Sbjct: 738  ---KLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMH 794

Query: 176  KQIINLLEDLKKME----------DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLA 225
                N++ +   M           D    +   +  +V S+E+  E+    N+ L+    
Sbjct: 795  HSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC- 853

Query: 226  ALKDEVVSVENELSE-LQEVEKKQKTLIEMYKTQVQKLQE--------AAEIVKSRCEN- 275
               +E+V ++ E+ E L + E+  ++ +     ++ KLQE         AE + S  EN 
Sbjct: 854  ---EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETL-SALENK 909

Query: 276  -----LLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCK 330
                 LL+   +  + + + ++K    +E  LKEL+ + ++L+  ++ +       +   
Sbjct: 910  EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969

Query: 331  GKCADQEHTIRELQGQVDGNH-NLLTKLSL------EEENCLIQLKCENLQQKLE--QMD 381
             +   +  T++E+   ++    NL+ K         E E  + +L  +  Q+KL   Q  
Sbjct: 970  EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029

Query: 382  AENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEE----IEKM 437
             E     + L+ + +  +  N K +    E T+L    +  LE+ ++  A+E    + K+
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089

Query: 438  SSRESALQIKILDLET-------------------------ELRKKNEEQNQLVCKMNSK 472
            +  E   Q  +L+LET                         E+    EEQN++  ++N  
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149

Query: 473  AQHQEVCLKEVQNSLEKSENQNESIKN 499
             Q  E  +K ++   E    ++E I+N
Sbjct: 1150 LQENEQLMKVMKTKHECQNLESEPIRN 1176



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 109/516 (21%), Positives = 216/516 (41%), Gaps = 61/516 (11%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            ENL   E  + +   +  ++ + +QE +   Q+  A TL A      ++   + LQ+   
Sbjct: 865  ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA------LENKEKELQLLND 918

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD 123
            K E E  +++E  KS    + + +L+     +E + +++      ++L K          
Sbjct: 919  KVETEQAEIQELKKS--NHLLEDSLKELQLLSETLSLEKKEMSSIISLNKRE-------- 968

Query: 124  HFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ-IETMKKQIINLL 182
                 IE+LT +        + T+   NA  +  +  +I+K+E     I+  +K I  L 
Sbjct: 969  -----IEELTQE--------NGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELS 1015

Query: 183  EDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 242
            +  K+ +      CEE       +  + +    +N+KL+  L        + +NEL +L+
Sbjct: 1016 DQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLK 1075

Query: 243  EVEKKQK----TLIEMYKTQVQKLQEAAEIVKS--RCENLLHKNNQIT-----KTKNKNV 291
            E   K+     T +   + + Q L    E V+   R E   ++NN  +     K +   +
Sbjct: 1076 EAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTL 1135

Query: 292  EKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNH 351
            ++ + +M+  + +L +  + L    +  HECQ +L+    + + +E      Q       
Sbjct: 1136 KEEQNKMQKEVNDLLQENEQLMKVMKTKHECQ-NLESEPIRNSVKERESERNQCNFKPQM 1194

Query: 352  NLLTK-LSLEEENC-LIQLKC--ENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE 407
            +L  K +SL+  N  L+QL+    N + KL++ + E + L+ +L      L+ SNL+   
Sbjct: 1195 DLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ-DM 1253

Query: 408  KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE------- 460
            +S E + L +  E   EE       E+    +  + LQ     L+T + K NE       
Sbjct: 1254 QSQEISGL-KDCEIDAEEKYISGPHELSTSQNDNAHLQ---CSLQTTMNKLNELEKICEI 1309

Query: 461  ---EQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQ 493
               E+ +LV ++N          +++   + K  N+
Sbjct: 1310 LQAEKYELVTELNDSRSECITATRKMAEEVGKLLNE 1345



 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 97/441 (21%), Positives = 181/441 (41%), Gaps = 72/441 (16%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQEL-SCLFQSEKANTLKANRFSQSVKVVHE---RL 58
            L  L   E  N NL   + E E   Q L S +  ++  +  +A    Q +  + E   ++
Sbjct: 1086 LTKLAFAEERNQNL---MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKM 1142

Query: 59   QIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVY 118
            Q +++    EN++L   +K ++TK    NL+S   +N     +    Q     +   +V 
Sbjct: 1143 QKEVNDLLQENEQL---MKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVK 1199

Query: 119  KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQI 178
            +  LD +   + +L + +R++E KL E+           EK   EK  L+ +++T++  +
Sbjct: 1200 EISLDSYNAQLVQLEAMLRNKELKLQES-----------EK---EKECLQHELQTIRGDL 1245

Query: 179  -INLLEDLKKMEDHGKNSCE-EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
              + L+D++  E  G   CE +   K  S  +E  T   +N  L+           S++ 
Sbjct: 1246 ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQ----------CSLQT 1295

Query: 237  ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
             +++L E+EK  + L      Q +K +   E+  SR E        IT T+     KM  
Sbjct: 1296 TMNKLNELEKICEIL------QAEKYELVTELNDSRSE-------CITATR-----KMAE 1337

Query: 297  QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTK 356
            ++   L E++ + D        L E     +   G+  +++H +         ++  LT 
Sbjct: 1338 EVGKLLNEVKILNDDSGLLHGELVEDIPGGEF--GEQPNEQHPVSLAPLDESNSYEHLTL 1395

Query: 357  LSLEEENCLIQLKCENLQQKLEQMDAENKELE----------KKLANQEECLKHSNLKFK 406
               E     +Q+    LQ+K   + +E+K L            +L    + LK  NL   
Sbjct: 1396 SDKE-----VQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLS 1450

Query: 407  EKSAEYTA-LARQLEAALEEG 426
                 +   L ++++  LEEG
Sbjct: 1451 TNLRNFQGDLVKEMQLGLEEG 1471


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  100 bits (249), Expect = 3e-21
 Identities = 103/521 (19%), Positives = 226/521 (43%), Gaps = 52/521 (9%)

Query: 1    MLLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60
            M  E++ D E++   +++K+ +KE  + +L      E+ ++L+  +  + ++   E L+ 
Sbjct: 1065 MSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEE 1124

Query: 61   QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
            +I        K+++    L  ++ + + +            E ++++    +K  +  ++
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184

Query: 121  RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
                       L  +  D  A+L E I      K   EK   EK+EL+++I+ M   I  
Sbjct: 1185 ATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEK---EKSELKMEIDDMASNI-- 1239

Query: 181  LLEDLKKMEDHGKNSCEEILRKVHSIEYENET-------LNLENTKLKTTLAALKDEVVS 233
              E L K + + + +C  +  +   I+ ++E        LN++  +L+T    L   V  
Sbjct: 1240 --EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297

Query: 234  VENELSELQEVEKKQKTLIEMYKTQVQK-------LQEAAEIVKSRCENLLHKNNQITKT 286
             E+ +S+L + ++     +E  K Q+++       +  A +  +  C+ L  +  +  + 
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA 1357

Query: 287  K----------NKNVEKMRGQMESH-LKELERVCDSLTAAERRLHECQESLQCCKGKCAD 335
            K          N  V + R + E+  ++  E + ++     +RL E +E+ +    KCA 
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCAS 1417

Query: 336  QEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQE 395
             E T + LQG+V+   +L+  L      C               +D + +  +K LA  +
Sbjct: 1418 LEKTKQRLQGEVE---DLMRDLERSHTAC-------------ATLDKKQRNFDKVLAEWK 1461

Query: 396  ECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETEL 455
            + L  S  + +    E  +L+ +L   +    ++V +++E +      LQ +I DL  ++
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTEL-FKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520

Query: 456  RK--KNEEQNQLVCKM-NSKAQHQEVCLKEVQNSLEKSENQ 493
             +  KN ++ +   K+   +    +V L+EV+ SLE  E++
Sbjct: 1521 AETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 122/572 (21%), Positives = 248/572 (43%), Gaps = 106/572 (18%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
            +++N  L  +V EKE+ I +L+   +S++A T +     + ++   +      H  ++  
Sbjct: 1285 QTQNGELSHRVEEKESLISQLT---KSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341

Query: 70   ---DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQ 120
               D L+E  +  E + AK  LQ  ++K  + V +  ++      Q+T  L++A K   Q
Sbjct: 1342 HDCDLLREQYE--EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399

Query: 121  RLDHFT----------GAIEKLTSQIRDQEAKLSETISASNAW-------KSHYEKIVIE 163
            RL               ++EK   +++ +   L   +  S+         + +++K++ E
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459

Query: 164  ----KTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK 219
                  E + ++E  +K+  +L  +L KM    +N+ EE++ ++ ++  EN+ L  E + 
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKM----RNAYEEVVDQLETLRRENKNLQEEISD 1515

Query: 220  LKTTLA-------------------------ALKDEVVSVENELSEL-----------QE 243
            L   +A                         AL++   S+E+E S++            E
Sbjct: 1516 LTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSE 1575

Query: 244  VEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK 303
            +++K     E  +   +  Q AAE ++S  +  +   N   + K K        ME  L 
Sbjct: 1576 LDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKK--------MEGDLN 1627

Query: 304  ELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL-EEE 362
            E+E     L  + R++ E Q+ L+  +G+  D +     L   +  N +L  +L++ E  
Sbjct: 1628 EME---IQLGHSNRQMAETQKHLRTVQGQLKDSQ---LHLDDALRSNEDLKEQLAIVERR 1681

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKL--ANQEECLKHS------NLKFKEKSAEYTA 414
            N L+  + E ++  LEQ +   +  E++L  A+    L HS      N K K+  A+   
Sbjct: 1682 NGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTK-KKLEADIAQ 1740

Query: 415  LARQLEAALEEGRQKVAEEIEKMSSRESALQIKIL----DLETELRKKNEEQNQLVCKMN 470
               ++E +++E R   AEE  K +  ++A+  + L    D    L +  +   Q V  + 
Sbjct: 1741 CQAEVENSIQESRN--AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1798

Query: 471  SKA-QHQEVCLKEVQNSLEKSENQNESIKNYL 501
             +  + +++ LK  +  ++K EN+   ++N L
Sbjct: 1799 HRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 108/535 (20%), Positives = 231/535 (43%), Gaps = 65/535 (12%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            ENL D E     L K     EA ++EL+   + E+    +     ++++     L+  I 
Sbjct: 900  ENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDID 959

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD 123
              E    K+++   + E K+   NL   M   E  + K    +K++      + ++Q LD
Sbjct: 960  DLELTLTKVEKEKHATENKVK--NLSEEMTALEENISKLTKEKKSL-----QEAHQQTLD 1012

Query: 124  HF------TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQ 177
                       + K+ +++  Q   L  ++      ++  E+    K +LE  ++  ++ 
Sbjct: 1013 DLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERA---KRKLEGDLKMSQES 1069

Query: 178  IINLLEDLKKMEDHGKNSCEEILR--------KVHSIEYENETLNLENTKLKTTLAALKD 229
            I++L  D +++E+  K    E+ +        +VHS++++         K+K   A +++
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK--------KIKELQARIEE 1121

Query: 230  EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK 289
                +E E +   ++EK++  L    +   ++L+EA+    ++ E        + K +  
Sbjct: 1122 LEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE--------MNKKREA 1173

Query: 290  NVEKMRGQMESHLKELERVCDSLTAAE----RRLHECQESLQCCKGKCADQEHTIRELQG 345
              +KMR  +E    + E    +L   +      L E  ++LQ  K K   ++    EL+ 
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK---SELKM 1230

Query: 346  QVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQM---DAENKELEKKLANQEECLKHSN 402
            ++D   + +  LS  + N  I+  C  ++ +  ++   D +  +L   L  Q+  L+  N
Sbjct: 1231 EIDDMASNIEALSKSKSN--IERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQN 1288

Query: 403  LKFKEKSAEYTALARQLEAA-------LEEGRQKVAEEIEKMSSRESALQIKILDLETEL 455
             +   +  E  +L  QL  +       LEE ++++ EE +  ++   ALQ    D +  L
Sbjct: 1289 GELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDL-L 1347

Query: 456  RKKNEEQNQLVCKMN---SKAQHQ--EVCLKEVQNSLEKSENQNESIKNYLQFLK 505
            R++ EE+ +   ++    SKA  +  +   K   ++++++E   E+ K   Q L+
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 92/501 (18%), Positives = 204/501 (40%), Gaps = 55/501 (10%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV 76
            K+K+ E +A ++        +++ +L    F   ++  +E +  Q+     EN  L+E +
Sbjct: 1461 KQKLDESQAELEAAQ-----KESRSLSTELFK--MRNAYEEVVDQLETLRRENKNLQEEI 1513

Query: 77   KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 136
              L  +IA    ++  N  EA              +K  K+ +Q       A+E++   +
Sbjct: 1514 SDLTEQIA----ETGKNLQEA--------------EKTKKLVEQEKSDLQVALEEVEGSL 1555

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
              +E+K+       +  KS  ++ VIEK E   Q++   ++    L+ +   E   +N  
Sbjct: 1556 EHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDA 1615

Query: 197  EEILRKVH--------SIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 248
              + +K+          + + N  +      L+T    LKD  + +++ L   +++ K+Q
Sbjct: 1616 LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDL-KEQ 1674

Query: 249  KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL---KEL 305
              ++E     + +  E  ++   + E     + Q     +  V+ +  Q  S +   K+L
Sbjct: 1675 LAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKL 1734

Query: 306  ER-VCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENC 364
            E  +       E  + E + + +  K    D      EL+ + D      T   LE    
Sbjct: 1735 EADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQD------TSAHLERMKK 1788

Query: 365  LIQLKCENLQQKLEQMD----AENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
             ++   ++LQ +L++ +       K+  +KL N+   L++     +++ AE    A + E
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYE 1848

Query: 421  AALEEGRQKVAEE---IEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQE 477
              ++E   +  E+   I ++      LQ K+   + +  +  E+ N  + +   + QH+ 
Sbjct: 1849 RKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCR-RVQHE- 1906

Query: 478  VCLKEVQNSLEKSENQNESIK 498
              L+E     + +E+Q   ++
Sbjct: 1907 --LEEAAERADIAESQVNKLR 1925



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 74/370 (20%), Positives = 171/370 (46%), Gaps = 37/370 (10%)

Query: 153  WKSHYEKI--VIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVH-----S 205
            W + + KI  +++  E E ++ TMK+      E+L + E   K   E+++  +       
Sbjct: 833  WMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQ 892

Query: 206  IEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEA 265
            ++ ++ET NL + + +     +K +++ +E ++ EL E  ++++ +      + + L++ 
Sbjct: 893  LQVQSETENLMDAEERCE-GLIKSKIL-LEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950

Query: 266  AEIVKSRCENL------LHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAA-ERR 318
               +K   ++L      + K    T+ K KN+ +    +E ++ +L +   SL  A ++ 
Sbjct: 951  CSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT 1010

Query: 319  LHECQESLQCCKGKC---ADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQ 375
            L + Q       G     A  E    +L+G ++    L  +  LE     ++   +  Q+
Sbjct: 1011 LDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKL--RADLERAKRKLEGDLKMSQE 1068

Query: 376  KLEQMDAENKELEKKLANQEECLKHSNLKFKEK---SAEYTALARQLEAALEEGRQKVAE 432
             +  ++ + +++E+KL  +E  L     K  ++   S ++    ++L+A +EE    + E
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE----LEE 1124

Query: 433  EIEKMSSRESALQIKILDLETELRKKNEEQNQ------LVCKMNSKAQHQEVCLKEVQNS 486
            EIE   +  + ++ +  DL  EL + +E   +         +MN K   +E   ++++  
Sbjct: 1125 EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK---REAEFQKMRRD 1181

Query: 487  LEKSENQNES 496
            LE++  Q+E+
Sbjct: 1182 LEEATLQHEA 1191



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 32/164 (19%), Positives = 72/164 (43%), Gaps = 18/164 (10%)

Query: 353 LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEY 412
           LL     E+E   ++   E  +++L + +A  KELE+K+ +  +  + ++L+ + +S   
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQ--EKNDLQLQVQSE-- 898

Query: 413 TALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCK---M 469
                       E      E  E +   +  L+ K+ +L   L ++ E  ++LV K   +
Sbjct: 899 -----------TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947

Query: 470 NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
             K    +  + +++ +L K E +  + +N ++ L      + E
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEE 991


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 108/510 (21%), Positives = 234/510 (45%), Gaps = 74/510 (14%)

Query: 13  NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL 72
           NT   +++ EK A +QE   L +SEK+  ++ N      K+   +L +   + +AE D L
Sbjct: 273 NTITDEELKEKNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHL 331

Query: 73  KEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKL 132
            + ++S+  K     LQ+++ +NE  +    ++Q+   + +     ++++  +   I++ 
Sbjct: 332 GKELQSVSAK-----LQAQVEENE--LWNRLNQQQEEKMWRQ----EEKIQEWEEKIQEQ 380

Query: 133 TSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM--ED 190
             +IR+QE K+ E            EK+  ++  +  + E M++Q   + E  +KM  ++
Sbjct: 381 EEKIREQEEKIRE----------QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 430

Query: 191 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 250
                 EE +R++    +E E +  +  K                 E  +++E EK+Q+ 
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEK---------------RQEEEKIREQEKRQEQ 475

Query: 251 LIEMYKTQVQKLQEAAEIVKS------RCENLLHKNNQITKTKNKNVEKMRGQMESHLKE 304
             +M++ Q +K++E  E ++       R E  +H+  +I + + +  ++   + E  ++E
Sbjct: 476 EAKMWR-QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534

Query: 305 LERVC---DSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 361
            E +    + +   E ++ + +E +   + K  DQE  IRE + +V        K+  +E
Sbjct: 535 QEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEE---KIREQE 591

Query: 362 ENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEA 421
           E      K    ++K+ + +   +E E+K+  QEE +     K +E+  +     R+ E 
Sbjct: 592 E------KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKM----RRQEE 641

Query: 422 ALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLK 481
            + E  +K+ E+ EK+  +E  +Q        E  +K  EQ + +C+   K Q QE  ++
Sbjct: 642 KIREQEKKIREQEEKIREQEEMMQ--------EQEEKMWEQEEKMCEQEEKMQEQEEKMR 693

Query: 482 EVQNSLEKSE----NQNESIKNYLQFLKTS 507
             +  + + E     Q E ++ + + L+ +
Sbjct: 694 RQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 106/518 (20%), Positives = 227/518 (43%), Gaps = 48/518 (9%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
           E E  +L  ++ +      EL     +      KA+R+ + +    + L +++++    +
Sbjct: 218 EGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITD 277

Query: 70  DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAI 129
           ++LKE    L+ K+    L         + +KE  R+    L++A  +  Q+        
Sbjct: 278 EELKEKNAKLQEKL---QLVESEKSEIQLNVKELKRK----LERAKLLLPQQ--QLQAEA 328

Query: 130 EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKME 189
           + L  +++   AKL   +  +  W    ++   +    E +I+  +++I    E +++ E
Sbjct: 329 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 388

Query: 190 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENEL-----SELQEV 244
           +  +   EE +R+   + +E E    E  + +  +   K+E +  + E+      +++E+
Sbjct: 389 EKIREQ-EEKMRRQEEMMWEKE----EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL 443

Query: 245 EKKQKTLIEMYKTQVQKLQEAAEI--VKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
           E+K     E  + Q +K QE  +I   + R E       Q  K + +  EK+R Q E   
Sbjct: 444 EEKMHEQ-EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE-EKIREQEEKMW 501

Query: 303 KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 362
           ++ E++ +     E    + QE +   + K  +QE    E+  Q +  H    K+  +EE
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE----EIWRQKEKIHEQEEKIRKQEE 557

Query: 363 NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
               Q      ++K+   + + +E E+K+  QEE ++    K +E+  +     R+ E  
Sbjct: 558 KMWRQ------EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI----REQEEM 607

Query: 423 LEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE---EQNQLVCKMNSKAQHQEVC 479
            +E  +K+ E+ EKM  +E  +Q    + E ++R++ E   EQ + + +   K + QE  
Sbjct: 608 TQEQEEKMGEQEEKMCEQEEKMQ----EQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 663

Query: 480 LKEVQNSL----EKSENQNESIKNYLQFLKTSYVTMFE 513
           ++E +  +    EK   Q E ++   + ++     M+E
Sbjct: 664 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701



 Score = 72.4 bits (176), Expect = 9e-13
 Identities = 82/413 (19%), Positives = 188/413 (45%), Gaps = 44/413 (10%)

Query: 24  EAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKI 83
           +A ++E     +  +    K  R  + ++   E++Q Q  K   + +K++E  + +  + 
Sbjct: 343 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 402

Query: 84  AK-WNLQSRMNKNEAIVMKEAS---RQKTVALKKASKVYKQRLDHFTGAIEKLTSQ---- 135
              W  + +M + E ++ ++     RQ+ +  +K  K+  + L+      EK+  Q    
Sbjct: 403 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKI--RELEEKMHEQEKIREQEEKR 460

Query: 136 -----IRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 190
                IR+QE +  +    +  W+   EKI  ++ ++  Q E M +Q   + E  K  E+
Sbjct: 461 QEEEKIREQEKRQEQE---AKMWRQE-EKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516

Query: 191 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 250
             +   EE+ R+   I  E E +  +  K+      ++ +   +  +  ++ + E+K + 
Sbjct: 517 EKRQEQEEMWRQEEKIR-EQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIRE 575

Query: 251 LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCD 310
             E    Q +K++E  E ++ + E  + +  ++T+ +    EKM G+ E      E++C+
Sbjct: 576 QEEKVWRQEEKIREQEEKIREQ-EEKIREQEEMTQEQE---EKM-GEQE------EKMCE 624

Query: 311 SLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKC 370
                E ++ E +E ++  + K  +QE  IRE + ++     ++ +   +EE    Q   
Sbjct: 625 Q----EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE---QEEKMWEQ--- 674

Query: 371 ENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 423
              ++K+ + + + +E E+K+  QEE +    ++ +++  +       LEAA+
Sbjct: 675 ---EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAAI 724



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 94/416 (22%), Positives = 183/416 (43%), Gaps = 55/416 (13%)

Query: 96  EAIVMKEASRQKTVALKKASKVYKQRLDHFTG-AIEKLTSQIRDQEAKLSETISASNAWK 154
           EA+  +  ++  T+ +    K   Q   +++  A+++L  + RD  ++L ++      WK
Sbjct: 180 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS------WK 233

Query: 155 SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLN 214
                   E  +    + T KK+    +E+L K  D              S+E    T+ 
Sbjct: 234 -----FAGELEQALSAVATQKKKADRYIEELTKERD------------ALSLELYRNTIT 276

Query: 215 LENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQV--QKLQEAAEIVKSR 272
            E  K K   A L++++  VE+E SE+Q   K+ K  +E  K  +  Q+LQ  A+ +   
Sbjct: 277 DEELKEKN--AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 334

Query: 273 CENLLHK------NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESL 326
            +++  K       N++    N+  E+   + E  ++E E   + +   E ++ E +E +
Sbjct: 335 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 391

Query: 327 QCCKGKCADQEHTIRELQGQVDGNHNLL----TKLSLEEENCLIQLKCENLQQKLEQMDA 382
           +  + K   QE  + E + ++     ++     K+  +EE  ++  K E +++  E+M  
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE--MMWEKEEKIRELEEKMHE 449

Query: 383 ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 442
           + K  E++   QEE      ++ +EK  E  A   + E  + E  +K+ E+ EKM  +E 
Sbjct: 450 QEKIREQEEKRQEE----EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE 505

Query: 443 ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIK 498
            +  +    E E R++ EE    + +   K + QE    E+    EK   Q E I+
Sbjct: 506 KIHEQEKIREEEKRQEQEE----MWRQEEKIREQE----EIWRQKEKIHEQEEKIR 553



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 73/361 (20%), Positives = 160/361 (44%), Gaps = 42/361 (11%)

Query: 4   ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
           E + + E +    ++K+ E+E  I+E     Q EK    +   + +  K+   R +  + 
Sbjct: 368 EKIQEWEEKIQEQEEKIREQEEKIRE-----QEEKMRRQEEMMWEKEEKM--RRQEEMMW 420

Query: 64  KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD 123
           ++E +  + +E +   E KI +  L+ +M++ E I  +E  RQ+   +++  K  +Q   
Sbjct: 421 EKEEKMRRQEEMMWEKEEKIRE--LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 478

Query: 124 HFTGAIEKLTSQIRDQEAKLSETISASNAW----KSHYEKIVIEKTELEVQIET------ 173
            +     +   +IR+QE K+ E       W    K H ++ + E+ + + Q E       
Sbjct: 479 MW-----RQEEKIREQEEKIRE--QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 531

Query: 174 ---------MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTL 224
                     K++I    E ++K E+      E++  +   I  + E +  +  K++   
Sbjct: 532 IREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQE 591

Query: 225 AALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQIT 284
             ++++   +  +    QE E+K     E    Q +K+QE  E ++ + E +  +  +I 
Sbjct: 592 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIR 651

Query: 285 KTKNK---NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIR 341
           + + K     E M+ Q E   ++ E++C+     E ++ E +E ++  + K  +QE  +R
Sbjct: 652 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQ----EEKMQEQEEKMRRQEEKMWEQEVRLR 707

Query: 342 E 342
           +
Sbjct: 708 Q 708



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 67/302 (22%), Positives = 133/302 (44%), Gaps = 32/302 (10%)

Query: 12  ENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKV--VHERLQIQIHKREAEN 69
           E  + ++K+ E+E   QE   + + EK    +A  + Q  K+    E+++ Q  K   + 
Sbjct: 445 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQE 504

Query: 70  DKLKEYVKSLETKIAKWNLQSRMNKNEAIV--MKEASRQKTVALKKASKVYKQRLDHFTG 127
           +K+ E  K  E +  K   Q  M + E  +   +E  RQK    ++  K+ KQ       
Sbjct: 505 EKIHEQEKIREEE--KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE------ 556

Query: 128 AIEKLTSQ---IRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED 184
             EK+  Q   + DQE K+ E       W+   EKI  ++ ++  Q E +++Q     E 
Sbjct: 557 --EKMWRQEEKMHDQEEKIRE--QEEKVWRQE-EKIREQEEKIREQEEKIREQEEMTQEQ 611

Query: 185 LKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEV 244
            +KM +  +  CE+       ++ + E +  +  K++     ++++   +  +   +QE 
Sbjct: 612 EEKMGEQEEKMCEQ----EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQ 667

Query: 245 EKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE 304
           E+K     E    Q +K+QE  E ++ + E +  +  ++ + + K        M+ H + 
Sbjct: 668 EEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK--------MQEHQEH 719

Query: 305 LE 306
           LE
Sbjct: 720 LE 721


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 109/511 (21%), Positives = 239/511 (46%), Gaps = 72/511 (14%)

Query: 38   KANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEA 97
            KA++ K+++  +  + + E+LQ ++   + EN++LKE            N    + + E 
Sbjct: 1029 KASSKKSHQIEELEQQI-EKLQAEVKGYKDENNRLKEKEHK--------NQDDLLKEKET 1079

Query: 98   IV--MKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWK- 154
            ++  +KE  ++K V L     V  Q +     A+ +LT  +   +AK+ E  +     K 
Sbjct: 1080 LIQQLKEELQEKNVTLD----VQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKV 1135

Query: 155  --SHYEKI---VIEKTELEVQIETMKKQIINLLED--------------LKKMEDHGKNS 195
              SH  K+   ++EK  + +++E   K+    L+D              LK+      N+
Sbjct: 1136 ECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNN 1195

Query: 196  CEEILRKVHSIEYENETLNLENTKLKTTLAA-------LKDEVVSVENELSELQEVEKKQ 248
             +++   +   E E ET   E  KLK  L+A       LK ++   E + ++L+E     
Sbjct: 1196 LQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDA 1255

Query: 249  KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKT---KNKNVEKMRGQM-----ES 300
            K  I+  + +V  +++  ++++ +   L  K NQ ++    K + +++++ Q+     E 
Sbjct: 1256 KKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEE 1315

Query: 301  HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
             +++ ER C  L   E+ + + + +L+  +    +Q+     L+ +++    L T+L   
Sbjct: 1316 AIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQV---LEAKLEEVERLATELEKW 1372

Query: 361  EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFK-------EKSAEYT 413
            +E C   L+ +N Q+  ++ +  N ++  KL N ++ L+ S  K+        E+     
Sbjct: 1373 KEKCN-DLETKNNQRSNKEHE-NNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLI 1430

Query: 414  ALARQLEAALEEGRQKVAEEIEKMSSRESALQI---KILDLETELRKKNEEQNQLVCKMN 470
              A++ E    +  +K AE+ E+   +++ ++I   ++ + +++L+K  EE++QLV  + 
Sbjct: 1431 TQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAAL- 1489

Query: 471  SKAQHQEVCLKEVQNSLEKSENQNESIKNYL 501
                  E+ LK + +S  + +N+ E +K  +
Sbjct: 1490 ------EIQLKALISSNVQKDNEIEQLKRII 1514



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 115/538 (21%), Positives = 235/538 (43%), Gaps = 82/538 (15%)

Query: 8    DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ-IHKRE 66
            D++S+  + +K+V E E    E      S   ++       +S +V     +I+ I   +
Sbjct: 782  DSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQ 841

Query: 67   AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEA----SRQKTVALKKASKVYKQRL 122
              N+ L+ ++ ++E ++ K   + +   N+ IV  +     S +K + L K  +  +   
Sbjct: 842  ENNEGLRAFLLTIENEL-KNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNY 900

Query: 123  DHFTGAIEKLTSQIRDQEAKL----SETISASNAWKSHYEKIVIEKTELEVQIETMKK-- 176
            D     +    S+ ++QE K+    +E  +A+ +  ++  +I +  T+++ ++ T+    
Sbjct: 901  DIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKID-ELRTLDSVS 959

Query: 177  QIINL----LEDLKK--MEDHGKNSCEEILRKVHSI-----EYENETLNLENTKLKTTLA 225
            QI N+    L DL     ED+  N+  ++L   + +     EY  +  N EN+       
Sbjct: 960  QISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENS------- 1012

Query: 226  ALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK 285
                 + ++  E  E+ +   K+   IE  + Q++KLQ   +  K        +NN++ +
Sbjct: 1013 -FHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKD-------ENNRLKE 1064

Query: 286  TKNKNVEKMRGQMESHLKELERVCDS-----------LTAAERRLHECQESLQCCKGKCA 334
             ++KN + +  + E+ +++L+                +   +R L E  + + C K K  
Sbjct: 1065 KEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIK 1124

Query: 335  DQEHTIRELQGQVDGNHNL-LTKLSLEEENCLIQLK--CENLQQKLEQMDAENKELEKKL 391
            + E TI E Q +V+ +H+  L +  LE+E+ +++L+   +  Q+ L+      K+L  K 
Sbjct: 1125 ELE-TILETQ-KVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVK- 1181

Query: 392  ANQEECLKHSNLKFKEKSAEYTALARQLEAAL---EEGRQKVAEEIEKMSSRESALQIKI 448
                       LK KE+  + T   + ++  L   EE  +   +E EK+    SA   + 
Sbjct: 1182 ----------ELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSART 1231

Query: 449  LDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQ-------------NSLEKSENQ 493
             +L+ +L++K E+   L  K+    +  +   KEV              N LEK +NQ
Sbjct: 1232 QNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQ 1289



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 107/490 (21%), Positives = 210/490 (42%), Gaps = 100/490 (20%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            ++++ + +   + L + V   +A I+EL  + +++K     + +  Q + +  E + +++
Sbjct: 1099 IQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDI-LEKESIILKL 1157

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 122
             +       LKE+ + L+  +        +N  E + +KE   Q T  L        Q +
Sbjct: 1158 ERN------LKEFQEHLQDSVKN---TKDLNVKE-LKLKEEITQLTNNL--------QDM 1199

Query: 123  DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTE----LEVQIETMKKQI 178
             H     E+     R +  KL E +SAS+A   + +  +  K E    L+ ++   KKQI
Sbjct: 1200 KHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQI 1259

Query: 179  INLLEDLKKMEDHGK-------------NSC-EEILRKVHSIEYENETLNLENTKLKTTL 224
              + +++  M D  K             N C +E+  K  +I+   E LN  N K++  +
Sbjct: 1260 KQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLN--NQKVEEAI 1317

Query: 225  AA---------LKDEVVS-VENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCE 274
                       +K++++  +   L E ++ + +Q  ++E    +V++L    E  K +C 
Sbjct: 1318 QQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCN 1377

Query: 275  NLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCA 334
            +L  KNNQ +  +++N   + G++ +   EL                 QES Q       
Sbjct: 1378 DLETKNNQRSNKEHENNTDVLGKLTNLQDEL-----------------QESEQ------- 1413

Query: 335  DQEHTIRELQGQVDGNHNLLTKLSLEEENCLI--QLKCENLQQKLEQMDAENKELEKKLA 392
                            +N   K  LEE+  LI    + EN++ K  +  AE++E   K  
Sbjct: 1414 ---------------KYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQ 1458

Query: 393  NQEECL------KHSNLK--FKEKSAEYTALARQLEAALEEGRQK--VAEEIEKMSSRES 442
            N+ E L      K S+L+   +E+     AL  QL+A +    QK    E+++++ S  S
Sbjct: 1459 NEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETS 1518

Query: 443  ALQIKILDLE 452
             ++ +I+D++
Sbjct: 1519 KIETQIMDIK 1528



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 84/432 (19%), Positives = 178/432 (41%), Gaps = 49/432 (11%)

Query: 74  EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLT 133
           E  +++ETK+   +L   + +N+A +  E  R+    ++   K             EKLT
Sbjct: 543 EETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKL------INEKKEKLT 596

Query: 134 SQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGK 193
            + + +E    E        ++ +++ ++++ E+   +E   ++ + + +DL    D  +
Sbjct: 597 LEFKIREEVTQEFTQYWAQREADFKETLLQEREI---LEENAERRLAIFKDLVGKCDTRE 653

Query: 194 NSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENEL--------SELQEVE 245
            + ++I       E     L L+  ++K  LA  K E++  + EL        S +QE+E
Sbjct: 654 EAAKDICATKVETEEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELE 713

Query: 246 KKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKEL 305
              K +I    TQ Q+++E   I+         K + I + +N     ++  ME+  K  
Sbjct: 714 TSNKKII----TQNQRIKELINIID-------QKEDTINEFQN-----LKSHMENTFKCN 757

Query: 306 ERVCDSLTAAERRL--HECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEEN 363
           ++   S      +L  +E  E  +  K K   +   + E + Q D        + +    
Sbjct: 758 DKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAI 817

Query: 364 CLIQLKCENLQQKLEQMD------AENKELEKKLANQEECLKHSNLKFKEKSAEYTALAR 417
              Q K E ++  + +++        N+ L   L   E  LK+     KE+ AE      
Sbjct: 818 TEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNE----KEEKAELNKQIV 873

Query: 418 QLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQE 477
             +  L    +K     +++   +S   I I +L  + + KN+EQ + + K++++    E
Sbjct: 874 HFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQ-KSKNQEQEEKIMKLSNEI---E 929

Query: 478 VCLKEVQNSLEK 489
              + + N++ +
Sbjct: 930 TATRSITNNVSQ 941


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 103/519 (19%), Positives = 239/519 (46%), Gaps = 51/519 (9%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L  L D  ++  N  KK+ E E HI +L     SE+A   KA +  + +    E L+ ++
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 122
                           +L++   +  L+++  + E  V+K+A  ++T + +  ++V + R 
Sbjct: 1156 ED-------------TLDSTATQQELRAK-REQEVTVLKKALDEETRSHE--AQVQEMRQ 1199

Query: 123  DHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 176
             H   A+E+LT Q+   +       K  +T+   NA  +   +++ +  +   ++E  KK
Sbjct: 1200 KH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ---EVEHKKK 1255

Query: 177  QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            ++   +++L+     G+ +  E+  KVH ++ E E++     + +     L  +V S+ +
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 237  ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
            +L + QE+ +++        T++++L+E     ++  ++ L +  +  +   +++  +  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 297  QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRELQGQVDG 349
            Q+    K+L+    ++ A E      Q+ ++    +  ++       E T   LQ ++D 
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 350  NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 409
                   + L+ +  L+    E  Q+K +Q+ AE K +  K A++ +    +  + +EK 
Sbjct: 1432 -----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKE 1482

Query: 410  AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 469
             +  +LAR LE ALE       EE+E+ +    A    ++  + ++ K   E  +    +
Sbjct: 1483 TKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 470  NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
             ++ +  +  L+E+++ L+ +E+    ++  +Q LK  +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 109/483 (22%), Positives = 215/483 (44%), Gaps = 60/483 (12%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV 76
            KK+  E+  H  E     + ++   L+A R   + +++   L+ Q+ + EA   KL+   
Sbjct: 916  KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEK 973

Query: 77   KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 136
             + E KI K        ++E +VM + + +    L K  K+ ++R       I  LT+ +
Sbjct: 974  VTAEAKIKKL-------EDEILVMDDQNNK----LSKERKLLEER-------ISDLTTNL 1015

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
             ++E K        N  +S         +ELEV+++  +K    L +  +K+E    +  
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 197  EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIE--- 253
            E+I      I      L  +  +L+  LA L DE+    N L +++E+E     L E   
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 254  -----MYKTQVQK--LQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 306
                   K + QK  L E  E +K+  E+ L      T T+    +++R + E  +  L+
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDS----TATQ----QELRAKREQEVTVLK 1180

Query: 307  RVCDSLTAA-ERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE---EE 362
            +  D  T + E ++ E ++       +  +Q    +  +  +D N   L K + +   E 
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
              L Q K + ++ K ++++A+ +EL+ K ++ E      N K  +   E  ++   L  A
Sbjct: 1241 RVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 423  LEEGRQ-KVAEEIEKMSSRESALQIKI-------LDLETELRKKNEEQNQLVCKMNSKAQ 474
              EG+  K+A+++  +SS+    Q  +       L++ T+LR+  EE+N L  +++ + +
Sbjct: 1300 --EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357

Query: 475  HQE 477
             ++
Sbjct: 1358 AKQ 1360



 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 128/565 (22%), Positives = 231/565 (40%), Gaps = 110/565 (19%)

Query: 18   KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVK 77
            KK F+KE  I+ L+  ++ + A   K  +          RLQ ++     + D  ++ V 
Sbjct: 1394 KKRFQKE--IENLTQQYEEKAAAYDKLEK-------TKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 78   SLETKIAKWNLQSRMNKN-EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTS 134
            +LE K  K++      KN  +    E  R +  A +K +K     + L+    A E+L  
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 135  QIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---- 190
              +  +A++ + +S+ +    +  ++   K  LE Q+E MK Q+  L ++L+  ED    
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 191  ---------------------HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 229
                                   +    ++ R++H  EYE E   LE+ + +  LAA   
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAK 1619

Query: 230  EVVSVENELSELQ-EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN 288
            +   +E +L +L+ + +   K   E  K Q++KLQ   +  +   E+     ++I  T  
Sbjct: 1620 K--KLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 289  KNVEKMRGQMESHLKELERVCDSLTAAERRLHEC---------------------QESLQ 327
            +N EK    +E+ L +L+   + L AAER   +                      Q+  +
Sbjct: 1677 EN-EKKAKSLEADLMQLQ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDA 382
              + + A  E  + E QG ++   + + K + + E    +L  E +  QK E    Q++ 
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 383  ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALE-EGRQKVA---------- 431
            +NKEL  KL   E  +K    KFK   A   A   QLE  +E E R+K A          
Sbjct: 1793 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 432  --------------------EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNS 471
                                E+ EK ++R   L+ ++ + E E ++ N  + +L  +++ 
Sbjct: 1850 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1909

Query: 472  KAQHQEVCLKEVQNSLEKSENQNES 496
              +  E   +EV     K    NE+
Sbjct: 1910 ATESNEAMGREVNALKSKLRRGNET 1934



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)

Query: 86   WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 145
            W L +++     +  +E   Q      + +K  +Q+ ++    +E+  SQ+ +++  L E
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 146  TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 194
             + A         ++  E  E+ V++   K+++  +L +    L++ ED G       K 
Sbjct: 895  QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947

Query: 195  SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 251
              +++L     +E E    + L LE    +  +  L+DE++ ++++ ++L    K++K L
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1004

Query: 252  IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 311
             E        L E  E           K   +TK KNK+ E M  ++E  LK+ E+    
Sbjct: 1005 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1052

Query: 312  LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 371
            L   +R+L          +G  +D    I +LQ Q+      L K   E +  L +L  E
Sbjct: 1053 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 372  -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
                 N  +K+ +++    +L++ L ++      +  + ++   E  AL  +LE  L+  
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1161

Query: 427  RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 478
                 +E+     +E  +  K LD ET        E+R+K+ +  + + +   + +  + 
Sbjct: 1162 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 479  CLKEVQNSLEK 489
             L + + +LEK
Sbjct: 1221 NLDKNKQTLEK 1231



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 43/230 (18%), Positives = 102/230 (44%), Gaps = 12/230 (5%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLK--- 73
            K+   EKE   +EL+       A   +  R    +  + E L+ +    EA +D+++   
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 74   EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLT 133
            +  + L  ++A     ++ N++    ++  +++    L +     K +      A+E   
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823

Query: 134  SQIRDQ-EAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG 192
            +Q+ +Q E +  E  +A+ + K   +K+     E+ +Q+E  +K    + E  K+  + G
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERK----MAEQYKEQAEKG 1875

Query: 193  KNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 242
                +++ R++   E E++ +N    KL+  L    +   ++  E++ L+
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 374
           C+G  A +    R+ Q         LT + + + NC   LK  N Q              
Sbjct: 797 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 847

Query: 375 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 430
            ++ E+M A+  EL+K    Q++    LK    K  + + E   L  QL+A  E     +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 902

Query: 431 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 490
             E E+M  R +A + ++ ++  E+  + EE+     ++ ++ +     + +++  LE+ 
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962

Query: 491 ENQNESIK 498
           E   + ++
Sbjct: 963 EAARQKLQ 970



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)

Query: 367  QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
            Q K EN  ++LEQ  ++  E +  L  Q +       + +E      A  ++LE  L E 
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 427  RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 486
              ++ EE E    +  A + K+     +L ++ EE+     K+  +    E  +K++++ 
Sbjct: 928  EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986

Query: 487  LEKSENQNESIKNYLQFLK 505
            +   ++QN  +    + L+
Sbjct: 987  ILVMDDQNNKLSKERKLLE 1005


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 103/519 (19%), Positives = 239/519 (46%), Gaps = 51/519 (9%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L  L D  ++  N  KK+ E E HI +L     SE+A   KA +  + +    E L+ ++
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 122
                           +L++   +  L+++  + E  V+K+A  ++T + +  ++V + R 
Sbjct: 1163 ED-------------TLDSTATQQELRAK-REQEVTVLKKALDEETRSHE--AQVQEMRQ 1206

Query: 123  DHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 176
             H   A+E+LT Q+   +       K  +T+   NA  +   +++ +  +   ++E  KK
Sbjct: 1207 KH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ---EVEHKKK 1262

Query: 177  QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            ++   +++L+     G+ +  E+  KVH ++ E E++     + +     L  +V S+ +
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 237  ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
            +L + QE+ +++        T++++L+E     ++  ++ L +  +  +   +++  +  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 297  QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRELQGQVDG 349
            Q+    K+L+    ++ A E      Q+ ++    +  ++       E T   LQ ++D 
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 350  NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 409
                   + L+ +  L+    E  Q+K +Q+ AE K +  K A++ +    +  + +EK 
Sbjct: 1439 -----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKE 1489

Query: 410  AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 469
             +  +LAR LE ALE       EE+E+ +    A    ++  + ++ K   E  +    +
Sbjct: 1490 TKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 470  NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
             ++ +  +  L+E+++ L+ +E+    ++  +Q LK  +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 109/483 (22%), Positives = 215/483 (44%), Gaps = 60/483 (12%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV 76
            KK+  E+  H  E     + ++   L+A R   + +++   L+ Q+ + EA   KL+   
Sbjct: 923  KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEK 980

Query: 77   KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 136
             + E KI K        ++E +VM + + +    L K  K+ ++R       I  LT+ +
Sbjct: 981  VTAEAKIKKL-------EDEILVMDDQNNK----LSKERKLLEER-------ISDLTTNL 1022

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
             ++E K        N  +S         +ELEV+++  +K    L +  +K+E    +  
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 197  EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIE--- 253
            E+I      I      L  +  +L+  LA L DE+    N L +++E+E     L E   
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 254  -----MYKTQVQK--LQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 306
                   K + QK  L E  E +K+  E+ L      T T+    +++R + E  +  L+
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDS----TATQ----QELRAKREQEVTVLK 1187

Query: 307  RVCDSLTAA-ERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE---EE 362
            +  D  T + E ++ E ++       +  +Q    +  +  +D N   L K + +   E 
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
              L Q K + ++ K ++++A+ +EL+ K ++ E      N K  +   E  ++   L  A
Sbjct: 1248 RVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 423  LEEGRQ-KVAEEIEKMSSRESALQIKI-------LDLETELRKKNEEQNQLVCKMNSKAQ 474
              EG+  K+A+++  +SS+    Q  +       L++ T+LR+  EE+N L  +++ + +
Sbjct: 1307 --EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364

Query: 475  HQE 477
             ++
Sbjct: 1365 AKQ 1367



 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 128/565 (22%), Positives = 231/565 (40%), Gaps = 110/565 (19%)

Query: 18   KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVK 77
            KK F+KE  I+ L+  ++ + A   K  +          RLQ ++     + D  ++ V 
Sbjct: 1401 KKRFQKE--IENLTQQYEEKAAAYDKLEK-------TKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 78   SLETKIAKWNLQSRMNKN-EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTS 134
            +LE K  K++      KN  +    E  R +  A +K +K     + L+    A E+L  
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 135  QIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---- 190
              +  +A++ + +S+ +    +  ++   K  LE Q+E MK Q+  L ++L+  ED    
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 191  ---------------------HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 229
                                   +    ++ R++H  EYE E   LE+ + +  LAA   
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAK 1626

Query: 230  EVVSVENELSELQ-EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN 288
            +   +E +L +L+ + +   K   E  K Q++KLQ   +  +   E+     ++I  T  
Sbjct: 1627 K--KLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 289  KNVEKMRGQMESHLKELERVCDSLTAAERRLHEC---------------------QESLQ 327
            +N EK    +E+ L +L+   + L AAER   +                      Q+  +
Sbjct: 1684 EN-EKKAKSLEADLMQLQ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDA 382
              + + A  E  + E QG ++   + + K + + E    +L  E +  QK E    Q++ 
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 383  ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALE-EGRQKVA---------- 431
            +NKEL  KL   E  +K    KFK   A   A   QLE  +E E R+K A          
Sbjct: 1800 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 432  --------------------EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNS 471
                                E+ EK ++R   L+ ++ + E E ++ N  + +L  +++ 
Sbjct: 1857 KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDE 1916

Query: 472  KAQHQEVCLKEVQNSLEKSENQNES 496
              +  E   +EV     K    NE+
Sbjct: 1917 ATESNEAMGREVNALKSKLRRGNET 1941



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)

Query: 86   WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 145
            W L +++     +  +E   Q      + +K  +Q+ ++    +E+  SQ+ +++  L E
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 146  TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 194
             + A         ++  E  E+ V++   K+++  +L +    L++ ED G       K 
Sbjct: 902  QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954

Query: 195  SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 251
              +++L     +E E    + L LE    +  +  L+DE++ ++++ ++L    K++K L
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1011

Query: 252  IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 311
             E        L E  E           K   +TK KNK+ E M  ++E  LK+ E+    
Sbjct: 1012 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1059

Query: 312  LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 371
            L   +R+L          +G  +D    I +LQ Q+      L K   E +  L +L  E
Sbjct: 1060 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 372  -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
                 N  +K+ +++    +L++ L ++      +  + ++   E  AL  +LE  L+  
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1168

Query: 427  RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 478
                 +E+     +E  +  K LD ET        E+R+K+ +  + + +   + +  + 
Sbjct: 1169 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 479  CLKEVQNSLEK 489
             L + + +LEK
Sbjct: 1228 NLDKNKQTLEK 1238



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 43/230 (18%), Positives = 102/230 (44%), Gaps = 12/230 (5%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLK--- 73
            K+   EKE   +EL+       A   +  R    +  + E L+ +    EA +D+++   
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 74   EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLT 133
            +  + L  ++A     ++ N++    ++  +++    L +     K +      A+E   
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830

Query: 134  SQIRDQ-EAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHG 192
            +Q+ +Q E +  E  +A+ + K   +K+     E+ +Q+E  +K    + E  K+  + G
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKL----KEILLQVEDERK----MAEQYKEQAEKG 1882

Query: 193  KNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 242
                +++ R++   E E++ +N    KL+  L    +   ++  E++ L+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 374
           C+G  A +    R+ Q         LT + + + NC   LK  N Q              
Sbjct: 804 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 854

Query: 375 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 430
            ++ E+M A+  EL+K    Q++    LK    K  + + E   L  QL+A  E     +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 909

Query: 431 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 490
             E E+M  R +A + ++ ++  E+  + EE+     ++ ++ +     + +++  LE+ 
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969

Query: 491 ENQNESIK 498
           E   + ++
Sbjct: 970 EAARQKLQ 977



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)

Query: 367  QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
            Q K EN  ++LEQ  ++  E +  L  Q +       + +E      A  ++LE  L E 
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 427  RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 486
              ++ EE E    +  A + K+     +L ++ EE+     K+  +    E  +K++++ 
Sbjct: 935  EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993

Query: 487  LEKSENQNESIKNYLQFLK 505
            +   ++QN  +    + L+
Sbjct: 994  ILVMDDQNNKLSKERKLLE 1012


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 103/519 (19%), Positives = 239/519 (46%), Gaps = 51/519 (9%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L  L D  ++  N  KK+ E E HI +L     SE+A   KA +  + +    E L+ ++
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 122
                           +L++   +  L+++  + E  V+K+A  ++T + +  ++V + R 
Sbjct: 1163 ED-------------TLDSTATQQELRAK-REQEVTVLKKALDEETRSHE--AQVQEMRQ 1206

Query: 123  DHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 176
             H   A+E+LT Q+   +       K  +T+   NA  +   +++ +  +   ++E  KK
Sbjct: 1207 KH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ---EVEHKKK 1262

Query: 177  QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            ++   +++L+     G+ +  E+  KVH ++ E E++     + +     L  +V S+ +
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322

Query: 237  ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
            +L + QE+ +++        T++++L+E     ++  ++ L +  +  +   +++  +  
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 297  QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRELQGQVDG 349
            Q+    K+L+    ++ A E      Q+ ++    +  ++       E T   LQ ++D 
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438

Query: 350  NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 409
                   + L+ +  L+    E  Q+K +Q+ AE K +  K A++ +    +  + +EK 
Sbjct: 1439 -----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKE 1489

Query: 410  AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 469
             +  +LAR LE ALE       EE+E+ +    A    ++  + ++ K   E  +    +
Sbjct: 1490 TKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1544

Query: 470  NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
             ++ +  +  L+E+++ L+ +E+    ++  +Q LK  +
Sbjct: 1545 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/535 (22%), Positives = 231/535 (43%), Gaps = 87/535 (16%)

Query: 18   KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVK 77
            KK F+KE  I+ L+  ++ + A   K  +          RLQ ++     + D  ++ V 
Sbjct: 1401 KKRFQKE--IENLTQQYEEKAAAYDKLEK-------TKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 78   SLETKIAKWNLQSRMNKN-EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTS 134
            +LE K  K++      KN  +    E  R +  A +K +K     + L+    A E+L  
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 135  QIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---- 190
              +  +A++ + +S+ +    +  ++   K  LE Q+E MK Q+  L ++L+  ED    
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 191  ---------------------HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 229
                                   +    ++ R++H  EYE E   LE+ + +  LAA   
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAK 1626

Query: 230  EVVSVENELSELQ-EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN 288
            +   +E +L +L+ + +   K   E  K Q++KLQ   +  +   E+     ++I  T  
Sbjct: 1627 K--KLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 289  KNVEKMRGQMESHLKELERVCDSLTAAERRLHEC---------------------QESLQ 327
            +N EK    +E+ L +L+   + L AAER   +                      Q+  +
Sbjct: 1684 EN-EKKAKSLEADLMQLQ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDA 382
              + + A  E  + E QG ++   + + K + + E    +L  E +  QK E    Q++ 
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799

Query: 383  ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 442
            +NKEL  KL   E  +K    KFK   A   A   QLE  +E+  ++     + +  ++ 
Sbjct: 1800 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856

Query: 443  ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 497
             L+  +L +E E RK  E+  +   K N++       +K+++  LE++E +++ I
Sbjct: 1857 KLKEILLQVEDE-RKMAEQYKEQAEKGNAR-------VKQLKRQLEEAEEESQRI 1903



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 109/483 (22%), Positives = 215/483 (44%), Gaps = 60/483 (12%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV 76
            KK+  E+  H  E     + ++   L+A R   + +++   L+ Q+ + EA   KL+   
Sbjct: 923  KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEK 980

Query: 77   KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 136
             + E KI K        ++E +VM + + +    L K  K+ ++R       I  LT+ +
Sbjct: 981  VTAEAKIKKL-------EDEILVMDDQNNK----LSKERKLLEER-------ISDLTTNL 1022

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
             ++E K        N  +S         +ELEV+++  +K    L +  +K+E    +  
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075

Query: 197  EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIE--- 253
            E+I      I      L  +  +L+  LA L DE+    N L +++E+E     L E   
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 254  -----MYKTQVQK--LQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 306
                   K + QK  L E  E +K+  E+ L      T T+    +++R + E  +  L+
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDS----TATQ----QELRAKREQEVTVLK 1187

Query: 307  RVCDSLTAA-ERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE---EE 362
            +  D  T + E ++ E ++       +  +Q    +  +  +D N   L K + +   E 
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
              L Q K + ++ K ++++A+ +EL+ K ++ E      N K  +   E  ++   L  A
Sbjct: 1248 RVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 423  LEEGRQ-KVAEEIEKMSSRESALQIKI-------LDLETELRKKNEEQNQLVCKMNSKAQ 474
              EG+  K+A+++  +SS+    Q  +       L++ T+LR+  EE+N L  +++ + +
Sbjct: 1307 --EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1364

Query: 475  HQE 477
             ++
Sbjct: 1365 AKQ 1367



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)

Query: 86   WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 145
            W L +++     +  +E   Q      + +K  +Q+ ++    +E+  SQ+ +++  L E
Sbjct: 842  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901

Query: 146  TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 194
             + A         ++  E  E+ V++   K+++  +L +    L++ ED G       K 
Sbjct: 902  QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 954

Query: 195  SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 251
              +++L     +E E    + L LE    +  +  L+DE++ ++++ ++L    K++K L
Sbjct: 955  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1011

Query: 252  IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 311
             E        L E  E           K   +TK KNK+ E M  ++E  LK+ E+    
Sbjct: 1012 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1059

Query: 312  LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 371
            L   +R+L          +G  +D    I +LQ Q+      L K   E +  L +L  E
Sbjct: 1060 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1109

Query: 372  -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
                 N  +K+ +++    +L++ L ++      +  + ++   E  AL  +LE  L+  
Sbjct: 1110 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1168

Query: 427  RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 478
                 +E+     +E  +  K LD ET        E+R+K+ +  + + +   + +  + 
Sbjct: 1169 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 479  CLKEVQNSLEK 489
             L + + +LEK
Sbjct: 1228 NLDKNKQTLEK 1238



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 103/465 (22%), Positives = 203/465 (43%), Gaps = 72/465 (15%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER-LQIQI 62
            +N+ + E     L+ ++ E +  ++EL    Q+ +   L+     Q++K   ER LQ + 
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 63   HKREAENDKLK----EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVY 118
             + E +  +L+    EY   LE +  +  L +   K     +K+   Q   A+K   +  
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 119  KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQI 178
            KQ        + KL +Q++D + +L +        ++  ++I     E E + ++++  +
Sbjct: 1652 KQ--------LRKLQAQMKDFQRELEDA-------RASRDEIFATAKENEKKAKSLEADL 1696

Query: 179  INLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENEL 238
            + L EDL   E   K +           + E E L  E     +   AL+DE   +E  +
Sbjct: 1697 MQLQEDLAAAERARKQA-----------DLEKEELAEELASSLSGRNALQDEKRRLEARI 1745

Query: 239  SELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQM 298
            ++L+E  ++++  +E    +V+K  + AE + +          + T  KN   E  R Q+
Sbjct: 1746 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----ERSTAQKN---ESARQQL 1797

Query: 299  ESHLKELERVCDSLTAAERRLHECQESLQC-CKGKCADQEHTIRELQGQVDGNHNLLTKL 357
            E   KEL            +LHE + +++   K   A  E  I +L+ QV          
Sbjct: 1798 ERQNKELRS----------KLHEMEGAVKSKFKSTIAALEAKIAQLEEQV---------- 1837

Query: 358  SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALAR 417
              E+E    Q   ++L+QK    D + KE+  ++ ++ +  +    + ++ +A    L R
Sbjct: 1838 --EQEAREKQAATKSLKQK----DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891

Query: 418  QLEAALEE------GRQKVAEEIEKMSSRESALQIKILDLETELR 456
            QLE A EE       R+K+  E+++ +    A+  ++  L+++LR
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 374
           C+G  A +    R+ Q         LT + + + NC   LK  N Q              
Sbjct: 804 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 854

Query: 375 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 430
            ++ E+M A+  EL+K    Q++    LK    K  + + E   L  QL+A  E     +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 909

Query: 431 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 490
             E E+M  R +A + ++ ++  E+  + EE+     ++ ++ +     + +++  LE+ 
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969

Query: 491 ENQNESIK 498
           E   + ++
Sbjct: 970 EAARQKLQ 977



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)

Query: 367  QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
            Q K EN  ++LEQ  ++  E +  L  Q +       + +E      A  ++LE  L E 
Sbjct: 875  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 427  RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 486
              ++ EE E    +  A + K+     +L ++ EE+     K+  +    E  +K++++ 
Sbjct: 935  EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 993

Query: 487  LEKSENQNESIKNYLQFLK 505
            +   ++QN  +    + L+
Sbjct: 994  ILVMDDQNNKLSKERKLLE 1012


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 103/519 (19%), Positives = 239/519 (46%), Gaps = 51/519 (9%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L  L D  ++  N  KK+ E E HI +L     SE+A   KA +  + +    E L+ ++
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRL 122
                           +L++   +  L+++  + E  V+K+A  ++T + +  ++V + R 
Sbjct: 1156 ED-------------TLDSTATQQELRAK-REQEVTVLKKALDEETRSHE--AQVQEMRQ 1199

Query: 123  DHFTGAIEKLTSQIRDQEA------KLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 176
             H   A+E+LT Q+   +       K  +T+   NA  +   +++ +  +   ++E  KK
Sbjct: 1200 KH-AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ---EVEHKKK 1255

Query: 177  QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVEN 236
            ++   +++L+     G+ +  E+  KVH ++ E E++     + +     L  +V S+ +
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315

Query: 237  ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
            +L + QE+ +++        T++++L+E     ++  ++ L +  +  +   +++  +  
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEE----RNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 297  QMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRELQGQVDG 349
            Q+    K+L+    ++ A E      Q+ ++    +  ++       E T   LQ ++D 
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431

Query: 350  NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKS 409
                   + L+ +  L+    E  Q+K +Q+ AE K +  K A++ +    +  + +EK 
Sbjct: 1432 -----LVVDLDNQRQLVS-NLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKE 1482

Query: 410  AEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKM 469
             +  +LAR LE ALE       EE+E+ +    A    ++  + ++ K   E  +    +
Sbjct: 1483 TKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL 1537

Query: 470  NSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
             ++ +  +  L+E+++ L+ +E+    ++  +Q LK  +
Sbjct: 1538 ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576



 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 123/535 (22%), Positives = 231/535 (43%), Gaps = 87/535 (16%)

Query: 18   KKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVK 77
            KK F+KE  I+ L+  ++ + A   K  +          RLQ ++     + D  ++ V 
Sbjct: 1394 KKRFQKE--IENLTQQYEEKAAAYDKLEK-------TKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 78   SLETKIAKWNLQSRMNKN-EAIVMKEASRQKTVALKKASKVYK--QRLDHFTGAIEKLTS 134
            +LE K  K++      KN  +    E  R +  A +K +K     + L+    A E+L  
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 135  QIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED---- 190
              +  +A++ + +S+ +    +  ++   K  LE Q+E MK Q+  L ++L+  ED    
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 191  ---------------------HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 229
                                   +    ++ R++H  EYE E   LE+ + +  LAA   
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH--EYETE---LEDERKQRALAAAAK 1619

Query: 230  EVVSVENELSELQ-EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN 288
            +   +E +L +L+ + +   K   E  K Q++KLQ   +  +   E+     ++I  T  
Sbjct: 1620 K--KLEGDLKDLELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 289  KNVEKMRGQMESHLKELERVCDSLTAAERRLHEC---------------------QESLQ 327
            +N EK    +E+ L +L+   + L AAER   +                      Q+  +
Sbjct: 1677 EN-EKKAKSLEADLMQLQ---EDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE-NLQQKLE----QMDA 382
              + + A  E  + E QG ++   + + K + + E    +L  E +  QK E    Q++ 
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792

Query: 383  ENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 442
            +NKEL  KL   E  +K    KFK   A   A   QLE  +E+  ++     + +  ++ 
Sbjct: 1793 QNKELRSKLHEMEGAVKS---KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849

Query: 443  ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 497
             L+  +L +E E RK  E+  +   K N++       +K+++  LE++E +++ I
Sbjct: 1850 KLKEILLQVEDE-RKMAEQYKEQAEKGNAR-------VKQLKRQLEEAEEESQRI 1896



 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 109/483 (22%), Positives = 215/483 (44%), Gaps = 60/483 (12%)

Query: 17   KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYV 76
            KK+  E+  H  E     + ++   L+A R   + +++   L+ Q+ + EA   KL+   
Sbjct: 916  KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD--LEEQLEEEEAARQKLQLEK 973

Query: 77   KSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQI 136
             + E KI K        ++E +VM + + +    L K  K+ ++R       I  LT+ +
Sbjct: 974  VTAEAKIKKL-------EDEILVMDDQNNK----LSKERKLLEER-------ISDLTTNL 1015

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
             ++E K        N  +S         +ELEV+++  +K    L +  +K+E    +  
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068

Query: 197  EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIE--- 253
            E+I      I      L  +  +L+  LA L DE+    N L +++E+E     L E   
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 254  -----MYKTQVQK--LQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 306
                   K + QK  L E  E +K+  E+ L      T T+    +++R + E  +  L+
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDS----TATQ----QELRAKREQEVTVLK 1180

Query: 307  RVCDSLTAA-ERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE---EE 362
            +  D  T + E ++ E ++       +  +Q    +  +  +D N   L K + +   E 
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
              L Q K + ++ K ++++A+ +EL+ K ++ E      N K  +   E  ++   L  A
Sbjct: 1241 RVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 423  LEEGRQ-KVAEEIEKMSSRESALQIKI-------LDLETELRKKNEEQNQLVCKMNSKAQ 474
              EG+  K+A+++  +SS+    Q  +       L++ T+LR+  EE+N L  +++ + +
Sbjct: 1300 --EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME 1357

Query: 475  HQE 477
             ++
Sbjct: 1358 AKQ 1360



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 90/431 (20%), Positives = 185/431 (42%), Gaps = 61/431 (14%)

Query: 86   WNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSE 145
            W L +++     +  +E   Q      + +K  +Q+ ++    +E+  SQ+ +++  L E
Sbjct: 835  WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894

Query: 146  TISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED----LKKMEDHG-------KN 194
             + A         ++  E  E+ V++   K+++  +L +    L++ ED G       K 
Sbjct: 895  QLQAET-------ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK 947

Query: 195  SCEEILRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTL 251
              +++L     +E E    + L LE    +  +  L+DE++ ++++ ++L    K++K L
Sbjct: 948  MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL---SKERKLL 1004

Query: 252  IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDS 311
             E        L E  E           K   +TK KNK+ E M  ++E  LK+ E+    
Sbjct: 1005 EERISDLTTNLAEEEE-----------KAKNLTKLKNKH-ESMISELEVRLKKEEKSRQE 1052

Query: 312  LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCE 371
            L   +R+L          +G  +D    I +LQ Q+      L K   E +  L +L  E
Sbjct: 1053 LEKLKRKL----------EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDE 1102

Query: 372  -----NLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
                 N  +K+ +++    +L++ L ++      +  + ++   E  AL  +LE  L+  
Sbjct: 1103 IAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS- 1161

Query: 427  RQKVAEEIEKMSSRESALQIKILDLET--------ELRKKNEEQNQLVCKMNSKAQHQEV 478
                 +E+     +E  +  K LD ET        E+R+K+ +  + + +   + +  + 
Sbjct: 1162 -TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 479  CLKEVQNSLEK 489
             L + + +LEK
Sbjct: 1221 NLDKNKQTLEK 1231



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 103/465 (22%), Positives = 203/465 (43%), Gaps = 72/465 (15%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER-LQIQI 62
            +N+ + E     L+ ++ E +  ++EL    Q+ +   L+     Q++K   ER LQ + 
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 63   HKREAENDKLK----EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVY 118
             + E +  +L+    EY   LE +  +  L +   K     +K+   Q   A+K   +  
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 119  KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQI 178
            KQ        + KL +Q++D + +L +        ++  ++I     E E + ++++  +
Sbjct: 1645 KQ--------LRKLQAQMKDFQRELEDA-------RASRDEIFATAKENEKKAKSLEADL 1689

Query: 179  INLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENEL 238
            + L EDL   E   K +           + E E L  E     +   AL+DE   +E  +
Sbjct: 1690 MQLQEDLAAAERARKQA-----------DLEKEELAEELASSLSGRNALQDEKRRLEARI 1738

Query: 239  SELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQM 298
            ++L+E  ++++  +E    +V+K  + AE + +          + T  KN   E  R Q+
Sbjct: 1739 AQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT-----ERSTAQKN---ESARQQL 1790

Query: 299  ESHLKELERVCDSLTAAERRLHECQESLQC-CKGKCADQEHTIRELQGQVDGNHNLLTKL 357
            E   KEL            +LHE + +++   K   A  E  I +L+ QV          
Sbjct: 1791 ERQNKELRS----------KLHEMEGAVKSKFKSTIAALEAKIAQLEEQV---------- 1830

Query: 358  SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALAR 417
              E+E    Q   ++L+QK    D + KE+  ++ ++ +  +    + ++ +A    L R
Sbjct: 1831 --EQEAREKQAATKSLKQK----DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884

Query: 418  QLEAALEE------GRQKVAEEIEKMSSRESALQIKILDLETELR 456
            QLE A EE       R+K+  E+++ +    A+  ++  L+++LR
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 32/188 (17%)

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-------------- 374
           C+G  A +    R+ Q         LT + + + NC   LK  N Q              
Sbjct: 797 CRGYLARKAFAKRQQQ---------LTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQV 847

Query: 375 -QKLEQMDAENKELEKKLANQEEC---LKHSNLKFKEKSAEYTALARQLEAALEEGRQKV 430
            ++ E+M A+  EL+K    Q++    LK    K  + + E   L  QL+A  E     +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-----L 902

Query: 431 AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS 490
             E E+M  R +A + ++ ++  E+  + EE+     ++ ++ +     + +++  LE+ 
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962

Query: 491 ENQNESIK 498
           E   + ++
Sbjct: 963 EAARQKLQ 970



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 30/139 (21%), Positives = 62/139 (44%), Gaps = 1/139 (0%)

Query: 367  QLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEG 426
            Q K EN  ++LEQ  ++  E +  L  Q +       + +E      A  ++LE  L E 
Sbjct: 868  QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 427  RQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNS 486
              ++ EE E    +  A + K+     +L ++ EE+     K+  +    E  +K++++ 
Sbjct: 928  EARLEEE-EDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDE 986

Query: 487  LEKSENQNESIKNYLQFLK 505
            +   ++QN  +    + L+
Sbjct: 987  ILVMDDQNNKLSKERKLLE 1005


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 107/529 (20%), Positives = 239/529 (45%), Gaps = 61/529 (11%)

Query: 13  NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL 72
           NT   +++ EK A +QE   L +SEK+  ++ N      K+   +L +   + +AE D L
Sbjct: 212 NTITDEELKEKNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHL 270

Query: 73  KEYVKSLETKIAKWNLQSRMNKNEAIV-MKEASRQKTVALKKASKVYKQRLDHFTGAIEK 131
            + ++S+  K     LQ+++ +NE    + +   +K    ++  + +++++      I +
Sbjct: 271 GKELQSVSAK-----LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325

Query: 132 LTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM--E 189
              +IR+QE K+         W+   EK+  ++  +  + E M++Q   + E  +KM  +
Sbjct: 326 QEEKIREQEEKMRR--QEEMMWEKE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ 382

Query: 190 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQK 249
           +      EE +R++    +E E +  +  K                 E  +++E EK+Q+
Sbjct: 383 EEMMWEKEEKIRELEEKMHEQEKIREQEEK---------------RQEEEKIREQEKRQE 427

Query: 250 TLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVC 309
              +M++ Q +K++E  E ++ + + +  +  +I + +    E+ R + E   ++ E++ 
Sbjct: 428 QEAKMWR-QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIH 486

Query: 310 DS--LTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL-------- 359
           +   +   + ++HE +E ++  + K   QE  IRE + ++      + +           
Sbjct: 487 EQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546

Query: 360 --------EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKE---K 408
                   E+E    + K +  + K+ + + + +E E+K+  QEE ++    K +E   K
Sbjct: 547 WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606

Query: 409 SAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCK 468
             +     R+ E  ++E  +K+ E+ EK+  +E   Q        E  +K  EQ + +C+
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ--------EQEEKMGEQEEKMCE 658

Query: 469 MNSKAQHQEVCL----KEVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
              K Q QE  +    ++++   +K   Q E I+   + ++     M+E
Sbjct: 659 QEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 104/491 (21%), Positives = 213/491 (43%), Gaps = 58/491 (11%)

Query: 24  EAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKI 83
           +A ++E     +  +    K  R  + ++   E++Q Q  K   + +K++E  + +  + 
Sbjct: 282 QAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQE 341

Query: 84  AK-WNLQSRMNKNEAIVMKEAS---RQKTVALKKASKVYKQ------RLDHFTGAIEKLT 133
              W  + +M + E ++ ++     RQ+ +  +K  K+ +Q      + +      EK+ 
Sbjct: 342 EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 401

Query: 134 SQ--IRDQEAKLSETISA----------SNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
            Q  IR+QE K  E              +  W+   EKI  ++ ++  Q + M +Q   +
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE-EKIREQEEKIREQEKKMWRQEEKI 460

Query: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
            E  K  E+  +   EE+ R+   I +E E +  +  K+      ++ +   V  +  ++
Sbjct: 461 HEQEKIREEEKRQEQEEMWRQEEKI-HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKI 519

Query: 242 QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQI-TKTKNKNVEKMRGQMES 300
           +E E+K +   E    Q +K++E  E+ +   E  +H+  +I  + K +  E    + E 
Sbjct: 520 REQEEKIREQEEKMWRQEEKIREQEEMWRE--EEKMHEQEKIWEEEKRQEQEDKMWRQEE 577

Query: 301 HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
            ++E E   + +   E ++ E +E  Q  + K   QE  IRE +           K+  +
Sbjct: 578 KIREQE---EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE----------EKIQEQ 624

Query: 361 EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
           EE      K    ++K+ + +   +E E+K+  QEE +     K +E+      + RQ E
Sbjct: 625 EE------KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE---TMWRQ-E 674

Query: 421 AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCL 480
             + E  +K+ E+ EK+  +E  +Q        E  +K  EQ + +C+   K Q QE  +
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQ--------EQEEKMWEQEEKMCEQEEKMQEQEEKM 726

Query: 481 KEVQNSLEKSE 491
           +  +  + + E
Sbjct: 727 RRQEEKMWEQE 737



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 94/426 (22%), Positives = 187/426 (43%), Gaps = 61/426 (14%)

Query: 96  EAIVMKEASRQKTVALKKASKVYKQRLDHFTG-AIEKLTSQIRDQEAKLSETISASNAWK 154
           EA+  +  ++  T+ +    K   Q   +++  A+++L  + RD  ++L ++      WK
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS------WK 172

Query: 155 SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLN 214
                   E  +    + T KK+    +E+L K  D              S+E    T+ 
Sbjct: 173 -----FAGELEQALSAVATQKKKADRYIEELTKERD------------ALSLELYRNTIT 215

Query: 215 LENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQV--QKLQEAAEIVKSR 272
            E  K K   A L++++  VE+E SE+Q   K+ K  +E  K  +  Q+LQ  A+ +   
Sbjct: 216 DEELKEKN--AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273

Query: 273 CENLLHK------NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESL 326
            +++  K       N++    N+  E+   + E  ++E E   + +   E ++ E +E +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 330

Query: 327 QCCKGKCADQEHTIRELQGQVDGNHNLL----TKLSLEEENCLIQLKCENLQQKLEQM-- 380
           +  + K   QE  + E + ++     ++     K+  +EE  ++  K E ++++ E M  
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE--MMWEKEEKMRRQEEMMWE 388

Query: 381 -DAENKELEKKLANQEECLKHSN-------LKFKEKSAEYTALARQLEAALEEGRQKVAE 432
            + + +ELE+K+  QE+  +          ++ +EK  E  A   + E  + E  +K+ E
Sbjct: 389 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448

Query: 433 EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSEN 492
           + +KM  +E  +  +    E E R++ EE    + +   K   QE    E+    EK   
Sbjct: 449 QEKKMWRQEEKIHEQEKIREEEKRQEQEE----MWRQEEKIHEQE----EIWRQKEKMHE 500

Query: 493 QNESIK 498
           Q E I+
Sbjct: 501 QEEKIR 506



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 57/292 (19%), Positives = 129/292 (44%), Gaps = 19/292 (6%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLF-QSEKANTLKANRFSQSVKV--VHERLQIQIHKRE 66
           E E    +++++ +E  I E   ++ Q EK +  +     Q  KV    E+++ Q  K  
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIR 527

Query: 67  AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 126
            + +K+    + +  +   W  + +M++ E I  +E  +++   + +  +  +++ +   
Sbjct: 528 EQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVW 587

Query: 127 GAIEKLTSQIRDQEAKLSETISASNAWK------SHYEKIVIEKTELEVQIETMKKQIIN 180
              EK    IR+QE K  E       WK         EKI  ++ ++  Q E +++Q   
Sbjct: 588 RQEEK----IREQEEKRQE--QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM 641

Query: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
             E  +KM +  +  CE+       ++ + ET+  +  K++     ++++   +  +   
Sbjct: 642 TQEQEEKMGEQEEKMCEQ----EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM 697

Query: 241 LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 292
           +QE E+K     E    Q +K+QE  E ++ + E +  +  ++ + + K  E
Sbjct: 698 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749



 Score = 38.1 bits (87), Expect = 0.019
 Identities = 42/198 (21%), Positives = 84/198 (42%), Gaps = 20/198 (10%)

Query: 4   ENLTDNESENTNLKKKVFEKEAHI--QELSCLFQSEKANTLKANRFSQSVKV--VHERLQ 59
           E   + E +    ++K+ E+E  +  QE     Q EK    +   + Q  K+    E++Q
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQ 622

Query: 60  IQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYK 119
            Q  K   + +K++E  +  + +  K   Q      +   M+E   Q+    ++  K+ +
Sbjct: 623 EQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE---QEETMWRQEEKIRE 679

Query: 120 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHY------EKIVIEKTELEVQIET 173
           Q        I +   +IR+QE  + E       W+         EK+  ++ ++  Q E 
Sbjct: 680 QEKK-----IREQEEKIREQEEMMQE--QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732

Query: 174 MKKQIINLLEDLKKMEDH 191
           M +Q + L +  +KM++H
Sbjct: 733 MWEQEVRLRQQEEKMQEH 750


>gi|4758650 kinesin family member 5C [Homo sapiens]
          Length = 957

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 104/504 (20%), Positives = 220/504 (43%), Gaps = 70/504 (13%)

Query: 31  SCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQS 90
           S L   ++A T+K N  S ++++  E  + +  K + +N  LK  ++ LE ++ +W    
Sbjct: 316 STLMFGQRAKTIK-NTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGE 374

Query: 91  RMNKNEAIVMKE-----------------------ASRQKTVALKKASKVYKQ------R 121
            + ++E I  K+                       ++ +K    ++ S +Y+Q       
Sbjct: 375 AVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDE 434

Query: 122 LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
           ++  +   EKL  Q+ DQ+  L+ T       +  YEKI  E T L+++ E  K ++  +
Sbjct: 435 INQQSQLAEKLKQQMLDQDELLAST-------RRDYEKIQEELTRLQIENEAAKDEVKEV 487

Query: 182 LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
           L+ L+++  +     +E+  K  + E   + L  + T L TT           + ELS+L
Sbjct: 488 LQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTT-----------QRELSQL 536

Query: 242 QEVEKKQKT-LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300
           QE+   QK    E+    ++ L E   I+ +     L   N + + +         +M+S
Sbjct: 537 QELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKS 596

Query: 301 HLKELERVCDSLTAAE----RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTK 356
            +K L      L +A+    R+++  +  L  C+   +  E  I+ L   +        +
Sbjct: 597 EVKSLVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQ 656

Query: 357 LSLEEENCLIQLKCENLQQKLEQMDAENKELE--KKLANQEECLKHSNLKFKEKSAEYTA 414
           L   +++   +L     Q+K+ ++  ++KE E   +L + EE  K              A
Sbjct: 657 LEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKK--------------A 702

Query: 415 LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 474
           L +Q+E+  E  +++++   +++  ++  +  +I DL  +L+ + E+ +    K+  + Q
Sbjct: 703 LEQQMESHREAHQKQLSRLRDEIEEKQKIID-EIRDLNQKLQLEQEKLSSDYNKLKIEDQ 761

Query: 475 HQEVCLKEVQNSLEKSENQNESIK 498
            +E+ L+++    +K E   E +K
Sbjct: 762 EREMKLEKLLLLNDKREQAREDLK 785



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 76/329 (23%), Positives = 146/329 (44%), Gaps = 43/329 (13%)

Query: 9   NESENTNLKKKVFEKEAHIQELSCLFQS--EKANTLKANRFSQSVKVVHERLQIQIHKRE 66
           +E E    +  + + EA I+ L+   Q+  +K   L+ ++ S S ++   R Q ++H+  
Sbjct: 622 SERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKMHEVS 681

Query: 67  AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 126
            + DK KE++  L+               +A  MK+A  Q+  + ++A +    RL    
Sbjct: 682 FQ-DKEKEHLTRLQ---------------DAEEMKKALEQQMESHREAHQKQLSRLRDEI 725

Query: 127 GAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN-----L 181
              +K+  +IRD   KL           S Y K+ IE  E E+++E  K  ++N      
Sbjct: 726 EEKQKIIDEIRDLNQKLQ---LEQEKLSSDYNKLKIEDQEREMKLE--KLLLLNDKREQA 780

Query: 182 LEDLKKMEDHGKNSCEEI--LRKVHSIEYE---NETLNLENTKLKTTLAALKDEVVSVEN 236
            EDLK +E+      + +  LRK+   +      +++ L+N     + AA K ++  +EN
Sbjct: 781 REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGS-AAQKQKISFLEN 839

Query: 237 ELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG 296
            L +L +V K+        + ++ KL++       R + L        K   +N  + R 
Sbjct: 840 NLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKAL----ESALKEAKENAMRDR- 894

Query: 297 QMESHLKELERVCDSLTAAE--RRLHECQ 323
             + + +E++R+ +++ A    RR H  Q
Sbjct: 895 --KRYQQEVDRIKEAVRAKNMARRAHSAQ 921


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 116/530 (21%), Positives = 238/530 (44%), Gaps = 51/530 (9%)

Query: 2   LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKA-NRFSQSVKVVHERLQI 60
           L E L +  + +T L+ ++ + +   QE   L QS  A   +A N   Q ++ + ++ Q 
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ- 523

Query: 61  QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVM----------KEASRQKTVA 110
           +I   EA   K KE +  LE +      + +  + E  V+          +E   Q T  
Sbjct: 524 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583

Query: 111 LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ 170
           LK  S+ +KQ  ++    +++  + +R  + ++    ++ N   S   +   + ++L++Q
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643

Query: 171 IETMKKQIINL-------LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTT 223
           I+   + +++          DL+   D  +N+ ++          + + LN   T+L   
Sbjct: 644 IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD----------KQQELNKITTQLDQV 693

Query: 224 LAALKDEVVSVENELSELQEVEKKQKTL---IEMYKTQVQKLQEAAEIVKSRCENLLHKN 280
            A L+D+        S L+E ++K  +L    E  + Q++KL+  +  VK+  E  L   
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753

Query: 281 NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTI 340
            Q  +  N ++E    ++    K+LE   + +++    L +  E+L+  K K   QE   
Sbjct: 754 QQ-QRQLNTDLELRATELS---KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 341 RELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKEL---EKKLANQEEC 397
           + L+   +   +  TK+  EE N  IQ     LQ+   + +A   EL   + KL+   + 
Sbjct: 810 QILKQDFE-TLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868

Query: 398 LKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRK 457
           LK+S  +F++++ +  A    LE   +E + ++  ++E     +        +L+  L K
Sbjct: 869 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK-------ELKKSLEK 921

Query: 458 KNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTS 507
           + E  +QL  ++NS  +     L + QN+L+++E + + ++  +  LK S
Sbjct: 922 EKEASHQLKLELNSMQEQ----LIQAQNTLKQNEKEEQQLQGNINELKQS 967



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 111/537 (20%), Positives = 221/537 (41%), Gaps = 58/537 (10%)

Query: 2   LLENLTDNESENTNLKKKVFEKEAHIQELSC-LFQSEKANTLKANRFSQSVKVVHERLQI 60
           L ENL   E + T L++K  E+    + +   L Q +       +R S S   +H R+ +
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH-RIHV 365

Query: 61  QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
           ++ ++     KLKE +  +ETK      + +  + +    +E   Q  + L+        
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQ----REEKEQHGLQLQSE------ 415

Query: 121 RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
                   I +L S++ + E +L E        +    + +++K   E Q+  ++ ++  
Sbjct: 416 --------INQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK---EQQVADLQLKLSR 464

Query: 181 LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTK--------LKTTLAALKDEVV 232
           L E LK+   +     +  L K      E + L    T         L+  L  + D+  
Sbjct: 465 LEEQLKEKVTNS-TELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 523

Query: 233 SVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE 292
            ++N L  L +  K+  +L+E  +  +    +A E   +    L  KN+ + +   +  E
Sbjct: 524 KIQN-LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTE 582

Query: 293 KMRGQMESHLKELERVCDS-------LTAAERRLHECQESLQCCKGKCADQEHTIRELQG 345
           K++ Q ESH +  E + D        L AA+ R+   + S+     +  + +  + +L  
Sbjct: 583 KLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642

Query: 346 QVDGNHNLL---------TKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEE 396
           Q+     LL          +  L+      Q   ++ QQ+L ++  +  ++  KL +++E
Sbjct: 643 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702

Query: 397 CLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQ------IKILD 450
                    KE   +Y +L ++ E    + ++  A+ +E  +S+E ALQ          D
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762

Query: 451 LE---TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFL 504
           LE   TEL K+ E + ++V       Q +   L+ ++  L K E + + +K   + L
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 123/537 (22%), Positives = 235/537 (43%), Gaps = 103/537 (19%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            L  + ++ E EN   K  + + E   +EL    Q +  NTLK  +           L+  
Sbjct: 869  LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK----------ELKKS 918

Query: 62   IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTV-ALKKASKVYKQ 120
            + K +  + +LK  + S++ ++ +   Q+ + +NE    +E   Q  +  LK++S+  K+
Sbjct: 919  LEKEKEASHQLKLELNSMQEQLIQ--AQNTLKQNEK---EEQQLQGNINELKQSSEQKKK 973

Query: 121  RLDHFTGAIEKLTSQIRDQEAKLSETIS-ASNAWKSHYEKIVIEKTELEVQIETMKK--- 176
            +++   G ++    Q  + E KL + ++ A+    +  EKI + +   E   ET K+   
Sbjct: 974  QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033

Query: 177  -------QIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD 229
                   +++   +DLK +E+    + E+++   + I  +N+ +     +LKT  A L+ 
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ----ELKTAKATLEQ 1089

Query: 230  EVVSVENELSE----LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK 285
            +    E +L E    LQ+++ K+K+L E  K  V +  + AEI + +C            
Sbjct: 1090 DSAKKEQQLQERCKALQDIQ-KEKSLKE--KELVNEKSKLAEIEEIKCR----------- 1135

Query: 286  TKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQG 345
             + K + K+  +++SH  E  +   +L  A++ L   Q+ L               ELQG
Sbjct: 1136 -QEKEITKLNEELKSHKLESIKEITNLKDAKQLL--IQQKL---------------ELQG 1177

Query: 346  QVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKF 405
            + D       K ++E+E         N Q   +Q+  E +EL+K+   +E  L HS +K 
Sbjct: 1178 KADS-----LKAAVEQEK-------RNQQILKDQVKKEEEELKKEFIEKEAKL-HSEIKE 1224

Query: 406  KE----KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELR----- 456
            KE    K  E  A       AL E    V +E +    R S L+ +  DL  E+      
Sbjct: 1225 KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1284

Query: 457  -KKNEEQNQLVCKMNSKAQHQ----EVCLKEVQNSLEKS---------ENQNESIKN 499
             + N+++ + + +   K + +    +  + E+Q  L+ +         ENQ+  IK+
Sbjct: 1285 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 122/582 (20%), Positives = 236/582 (40%), Gaps = 113/582 (19%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTL---------KANRFSQSVKVV 54
            EN++  E E  +L  K+   E     L+ L   EK +TL         K    S+S K  
Sbjct: 537  ENISLLEKEREDLYAKIQAGEGETAVLNQL--QEKNHTLQEQVTQLTEKLKNQSESHKQA 594

Query: 55   HERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA 114
             E L  Q+ +++A     ++ V SLET + + N Q   +K +   +    + KT  L  A
Sbjct: 595  QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654

Query: 115  SKVY---------------------KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAW 153
                                     +Q L+  T  ++++T++++D++   S+  S    +
Sbjct: 655  EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714

Query: 154  KSHY------------------------------------------EKIVIEKTELEVQI 171
            K  Y                                            + +  TEL  Q+
Sbjct: 715  KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774

Query: 172  ETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEV 231
            E  K+ + +   DL+K  +    + E I +K+   E E + L  +   L        +E+
Sbjct: 775  EMEKEIVSSTRLDLQKKSE----ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830

Query: 232  VS-VENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKN 290
             + ++  ++ELQ+V+ +++ L+    T   KL + ++ +K+  ++   K NQ  K    +
Sbjct: 831  NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN-SKSEFEKENQKGKAAILD 889

Query: 291  VEK--------MRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRE 342
            +EK        ++ QME+ LKE + +  SL   +   H+ +  L   + +    ++T+++
Sbjct: 890  LEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ 949

Query: 343  ---LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLK 399
                + Q+ GN N L + S +++      + E LQ +L+    +  ELE KL  Q     
Sbjct: 950  NEKEEQQLQGNINELKQSSEQKKK-----QIEALQGELKIAVLQKTELENKLQQQ----- 999

Query: 400  HSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSS----RESALQIKILDLETEL 455
                    ++A+  A  ++  + L+   +K  E  +++ S    RES L     DL++  
Sbjct: 1000 ------LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVE 1053

Query: 456  RKKNEEQNQLVCKMNSKAQHQEVC--LKEVQNSLEKSENQNE 495
             K +  Q  L+   N      ++   LK  + +LE+   + E
Sbjct: 1054 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 108/505 (21%), Positives = 212/505 (41%), Gaps = 85/505 (16%)

Query: 17  KKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH------KREAEND 70
           ++KV      + + + + Q  K   L+         +  E +Q+Q        +RE E++
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249

Query: 71  KLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 130
           KLK+  K L+++ A                                           + E
Sbjct: 250 KLKDECKKLQSQYA-------------------------------------------SSE 266

Query: 131 KLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 190
              SQ+R + AK  + ++    +    +K+     EL  + +T+ + ++   +D  K+E+
Sbjct: 267 ATISQLRSELAKGPQEVA---VYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323

Query: 191 HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQK- 249
             K++ E + +K  +I+      +L+  +L++ L+A +  +  +  ELSE  E  +K K 
Sbjct: 324 --KHNEESVSKK--NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379

Query: 250 ------TLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK 303
                 T  +  K + ++LQ+  E  +     L  + NQ+  +K    E+  G+    LK
Sbjct: 380 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLLETERQLGEAHGRLK 438

Query: 304 ELERV-CDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 362
           E  ++  + L   E+++ + Q  L   + +  ++     ELQ Q+D      TK   +E+
Sbjct: 439 EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD-----KTKQQHQEQ 493

Query: 363 NCLIQ---LKCENLQQKLEQMDAENKELEKKLANQEECLKHS--NLKFKEKSAEYTALAR 417
             L Q    K    Q  LEQ+  +  + ++K+ N E  L+ S  N+   EK  E      
Sbjct: 494 QALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE------ 547

Query: 418 QLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQE 477
            L A ++ G  + A  + ++  +   LQ ++  L  +L+ ++E   Q    ++ + Q Q+
Sbjct: 548 DLYAKIQAGEGETA-VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQK 606

Query: 478 VCLKEVQN---SLEKSENQNESIKN 499
             L+  Q+   SLE S N+  S  N
Sbjct: 607 AHLRAAQDRVLSLETSVNELNSQLN 631



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 70/302 (23%), Positives = 136/302 (45%), Gaps = 32/302 (10%)

Query: 221 KTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAE--------IVKSR 272
           ++ LA  +D+V  +  E+ +LQ   K++K   E  K +++K Q   +        +  S 
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 273 CE-NLLHKNNQITKTKNKNVEKMRGQMESHLKEL-ERVCD--SLTAAERRLHECQESLQC 328
            E   L +  +  +T+N N+++M+   E    +L   + D  S    ER L E  E    
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELE 388
              +  ++E T+ +     D    LL +  +E+   +++ +   +Q  ++ M  E +   
Sbjct: 195 RLTEELNKEATVIQ-----DLKTELLQRPGIEDV-AVLKKELVQVQTLMDNMTLERERES 248

Query: 389 KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVA---EEIEKMSSRESALQ 445
           +KL  ++EC      K + + A   A   QL + L +G Q+VA   +E++K+ S  + L 
Sbjct: 249 EKL--KDEC-----KKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELT 301

Query: 446 IKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK 505
            K   L   L KK ++      K+  K   + V  K +Q +L + +   + +++ L   +
Sbjct: 302 QKNQTLTENLLKKEQDYT----KLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASE 357

Query: 506 TS 507
           TS
Sbjct: 358 TS 359


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 110/493 (22%), Positives = 226/493 (45%), Gaps = 56/493 (11%)

Query: 13  NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL 72
           NT   +++ EK A +QE   L +SEK+  ++ N      K+   +L +   + +AE D L
Sbjct: 212 NTITDEELKEKNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHL 270

Query: 73  KEYVKSLETKIAKWNLQSRMNKNEAIV-MKEASRQKTVALKKASKVYKQRLDHFTGAIEK 131
            + ++S+  K     LQ+++ +NE    + +   +K    ++  + +++++      I +
Sbjct: 271 GKELQSVSAK-----LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 325

Query: 132 LTSQIRDQEAKL---SETISASNAWKSHYEKIVIEKTELEVQIETM---KKQIINLLEDL 185
              +IR+QE K+    E +          E+++ EK E   ++E M   K++ I  LE+ 
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEK 385

Query: 186 -----KKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
                K  E   K   EE +R+    + +   +  +  K++     ++++   +  +  +
Sbjct: 386 MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445

Query: 241 LQEVEK-----KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMR 295
           + E EK     K++   EM++ Q +K++E  EI +              K K    EK+R
Sbjct: 446 IHEQEKIREEEKRQEQEEMWR-QEEKIREQEEIWRQ-------------KEKMHEQEKIR 491

Query: 296 GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 355
            Q E   ++ E++ D     E ++ E +E +   + K  +QE  IRE + ++     ++ 
Sbjct: 492 KQEEKVWRQEEKMHDQ----EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ 547

Query: 356 KLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTAL 415
           +   +EE    Q +    Q+K+ + + + +E E+K+  Q+E ++      +EK  E    
Sbjct: 548 E---QEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ----EEKIWEQEEK 600

Query: 416 ARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQH 475
            R+ E  ++E  +K+ E+ EKM  +E  +Q        E  +K   Q + + +   + + 
Sbjct: 601 IREQEEMMQEQEEKMWEQEEKMCEQEEKMQ--------EQEEKMRRQEEKMWEQEVRLRQ 652

Query: 476 QEVCLKEVQNSLE 488
           QE  ++E Q  LE
Sbjct: 653 QEEKMQEHQEHLE 665



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 101/527 (19%), Positives = 223/527 (42%), Gaps = 61/527 (11%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
           E E  +L  ++ +      EL     +      KA+R+ + +    + L +++++    +
Sbjct: 157 EGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITD 216

Query: 70  DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAI 129
           ++LKE    L+ K+    L         + +KE  R+    L++A  +  Q+        
Sbjct: 217 EELKEKNAKLQEKL---QLVESEKSEIQLNVKELKRK----LERAKLLLPQQ--QLQAEA 267

Query: 130 EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKME 189
           + L  +++   AKL   +  +  W    ++   +    E +I+  +++I    E +++ E
Sbjct: 268 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE 327

Query: 190 DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQK 249
           +  +   EE +R+   + +E                  K+E +  + E+  + E E+K +
Sbjct: 328 EKIREQ-EEKMRRQEEMMWE------------------KEEKMRRQEEM--MWEKEEKMR 366

Query: 250 TLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE--- 306
            L EM   + +K++E         E  +H+  +I + + K  E+ + + +   +E E   
Sbjct: 367 RLEEMMWEKEEKIREL--------EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 418

Query: 307 -RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCL 365
            R  + +   E ++ E ++ +   + K  +QE    E + Q         +   E+E   
Sbjct: 419 WRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIW 478

Query: 366 IQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKF---KEKSAEYTALARQLEAA 422
            Q +  + Q+K+ + + +    E+K+ +QEE ++    K    +EK  E     R+ E  
Sbjct: 479 RQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK 538

Query: 423 LEEGRQKVAEEIEKMSSRESALQ---------IKILDLETELRKKNE---EQNQLVCKMN 470
           + E  + + E+ EKM  +E  +Q          KI + E ++R++ E   EQ + + +  
Sbjct: 539 IREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQE 598

Query: 471 SKAQHQEVCLKEVQNSL----EKSENQNESIKNYLQFLKTSYVTMFE 513
            K + QE  ++E +  +    EK   Q E ++   + ++     M+E
Sbjct: 599 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 88/413 (21%), Positives = 181/413 (43%), Gaps = 45/413 (10%)

Query: 96  EAIVMKEASRQKTVALKKASKVYKQRLDHFTG-AIEKLTSQIRDQEAKLSETISASNAWK 154
           EA+  +  ++  T+ +    K   Q   +++  A+++L  + RD  ++L ++      WK
Sbjct: 119 EALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDS------WK 172

Query: 155 SHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLN 214
                   E  +    + T KK+    +E+L K  D              S+E    T+ 
Sbjct: 173 -----FAGELEQALSAVATQKKKADRYIEELTKERD------------ALSLELYRNTIT 215

Query: 215 LENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQV--QKLQEAAEIVKSR 272
            E  K K   A L++++  VE+E SE+Q   K+ K  +E  K  +  Q+LQ  A+ +   
Sbjct: 216 DEELKEKN--AKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273

Query: 273 CENLLHK------NNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESL 326
            +++  K       N++    N+  E+   + E  ++E E   + +   E ++ E +E +
Sbjct: 274 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKI 330

Query: 327 QCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKE 386
           +  + K   QE  + E + ++     ++ +   EE+   ++      ++K+ +++ +  E
Sbjct: 331 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRLEEMMWEKEEKIRELEEKMHE 388

Query: 387 LEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQI 446
            EK    +E+  +   ++ +EK  E  A   + E  + E  +K+ E+ +KM  +E  +  
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448

Query: 447 KILDLETELRKKNEEQNQLVCKMNSKAQHQEVC--LKEVQNSLEKSENQNESI 497
           +    E E R++ EE    + +   K + QE     KE  +  EK   Q E +
Sbjct: 449 QEKIREEEKRQEQEE----MWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497


>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
          Length = 1979

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 138/568 (24%), Positives = 250/568 (44%), Gaps = 97/568 (17%)

Query: 8   DNESENTNLKKK----VFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHER---LQI 60
           DN     NLK K    V EKE  +  LS   +  + + LK N   + +K    R   L  
Sbjct: 410 DNSLAEDNLKLKMRIEVLEKEKSL--LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDS 467

Query: 61  QIH----KREAENDKLKEYVKSLETKIAKWNLQSRMN----KNEAIVMKEASRQKTVA-- 110
           ++H      EA+  +L + +   ET IA+     R N    K+  ++  + S+Q+     
Sbjct: 468 ELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDS 527

Query: 111 ----LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTE 166
               LK+     K+R+         +T ++  Q+ KL ++  A N      +K+  +   
Sbjct: 528 IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVEN 587

Query: 167 LEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLE-NTKLKTTLA 225
           L  Q+   ++  +++ ++  ++++H + + EE+ R  + +    ++LN + N+  K TL 
Sbjct: 588 LVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM---QSLNQDSNSNFKDTLL 644

Query: 226 ALKD-EVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQIT 284
             ++ EV +++  LSEL+++ +  K +    K + +KL  A E V+ + E  L  NNQ++
Sbjct: 645 KEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704

Query: 285 KTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQ 344
             KN  VE ++  ME    E E     L  A++RL E          +    E TI EL 
Sbjct: 705 LEKNTIVETLK--MEKGEIEAE-----LCWAKKRLLE----------EANKYEKTIEELS 747

Query: 345 GQVDGNHNLLTKLSLEEENCL-----IQLKCENLQQKLEQMDAENKE----LEKKLANQE 395
              + N    + L LE E+ +       ++   L++ +EQMD ++KE    L   L  Q+
Sbjct: 748 NARNLN---TSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQK 804

Query: 396 -------------ECLKHSNLKFKEKSAEYTALARQLE-------------AALEEGRQK 429
                        E LK  + K +E+  +Y+   R+ E              +++E    
Sbjct: 805 QLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864

Query: 430 VAEEIEKMSSRES----ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQN 485
           + EE+E++   +S        K LD  TEL  +       V ++N+  +H E   +E+++
Sbjct: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASE-------VSQLNTIKEHLE---EEIKH 914

Query: 486 SLEKSENQNESIKNYLQFLKTSYVTMFE 513
             +  E+QN+S    LQ L+     M E
Sbjct: 915 HQKIIEDQNQSKMQLLQSLQEQKKEMDE 942



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 95/471 (20%), Positives = 208/471 (44%), Gaps = 71/471 (15%)

Query: 55  HERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA 114
           H++   +I +R  E  +L +Y + +E ++     Q      E  + K    QKT+ + + 
Sbjct: 243 HQQKLTEISRRHRE--ELSDYEERIE-ELENLLQQGGSGVIETDLSKIYEMQKTIQVLQI 299

Query: 115 SKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETM 174
            KV        T  +E+L  +I+D   KLS   +  +  +   E++ +EK ++  + E +
Sbjct: 300 EKVES------TKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENL 353

Query: 175 KKQIINLLEDLKKMED---------HGKNSCEEILRKVHSI-EYENETLNLENTKLKTTL 224
           K +   L     K  D             S EE+ R   ++ + ENE + L +     +L
Sbjct: 354 KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL 413

Query: 225 AALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQ----KLQEAAEIVKSRCENLLHKN 280
           A  +D +     +L    EV +K+K+L+   K ++Q    KL    E++KS     +  +
Sbjct: 414 A--EDNL-----KLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLD 466

Query: 281 NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTI 340
           +++   +  N+E    ++   + E E +   +   +R+  E  + +   K + + Q++  
Sbjct: 467 SELHDLR-LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE- 524

Query: 341 RELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKH 400
                      ++++KL  +           + ++++ Q++ +  ++ K+L  Q+E L  
Sbjct: 525 ---------GDSIISKLKQD---------LNDEKKRVHQLEDDKMDITKELDVQKEKLIQ 566

Query: 401 SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNE 460
           S +   +       L +Q    LE+  + + +++ K      ++Q + L+L+  +R+  E
Sbjct: 567 SEVALND-----LHLTKQ---KLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEE 618

Query: 461 E----QNQLVCKMN--SKAQHQEVCLKE-------VQNSLEKSENQNESIK 498
           E    +N+L+  +N  S +  ++  LKE       ++ +L + E  NE++K
Sbjct: 619 ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 80/443 (18%), Positives = 176/443 (39%), Gaps = 38/443 (8%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
            + E   L+K + EK+A I+ L    ++    +      S+  +  HE+   +I + + + 
Sbjct: 1346 QQELEELRKSLQEKDATIRTLQ---ENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQ 1402

Query: 70   DKLKEYVKSLETKIAKWN---LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 126
            D L++ +K  +  I   +   L S  N    +   E  RQ    LK+   + +  +    
Sbjct: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLK 1462

Query: 127  GAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLK 186
            G  EK+    R +E +  + +  +N       K  +   E E +  +MK++ +   + LK
Sbjct: 1463 GENEKIVETYRGKETEY-QALQETNM------KFSMMLREKEFECHSMKEKALAFEQLLK 1515

Query: 187  KMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEK 246
            + E        ++L  V S++ +      E  ++   L   + E  +++NE+  L++ E 
Sbjct: 1516 EKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEF 1575

Query: 247  KQKTLIEMYKTQVQKLQEA----AEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
            +    +E  +  + + +++    A   + R   L  K   + +    +   M        
Sbjct: 1576 RSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS 1635

Query: 303  KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 362
             ++E + + L    ++  E    L   + +      ++  LQ        ++ +   +EE
Sbjct: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQ--------MVLEHFQQEE 1687

Query: 363  NCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
              +   + E  +Q + +     + LE K+ + +ECL  +N      S     L  QL+  
Sbjct: 1688 KAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSAS----RLTEQLDVK 1743

Query: 423  LE---------EGRQKVAEEIEK 436
             E         E RQ++ ++++K
Sbjct: 1744 EEQIEELKRQNELRQEMLDDVQK 1766



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 112/527 (21%), Positives = 225/527 (42%), Gaps = 82/527 (15%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKA----NRFSQSVKVVHER 57
            L +NL++ E  N NLKK  F+ +   ++L    +  +    +     N+ S     + E 
Sbjct: 654  LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713

Query: 58   LQIQIHKREAE----NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKK 113
            L+++  + EAE      +L E     E  I +  L +  N N + +  E      +  KK
Sbjct: 714  LKMEKGEIEAELCWAKKRLLEEANKYEKTIEE--LSNARNLNTSALQLEHEHLIKLNQKK 771

Query: 114  ASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIET 173
              ++ +         ++K   Q+     +  + +S+S   +    +++ +K   E+ IE 
Sbjct: 772  DMEIAE---------LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK---EIFIEK 819

Query: 174  MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNL---ENTKLKTTLAALKDE 230
            +K++   L E+L K     + +  EILR+  +IE ++ +L     EN  L+  L  L++E
Sbjct: 820  LKERSSKLQEELDKYSQALRKN--EILRQ--TIEEKDRSLGSMKEENNHLQEELERLREE 875

Query: 231  ---------------VVSVENELSEL--------QEVEKKQKTLIEMYKTQVQKLQEAAE 267
                           V  + +E+S+L        +E++  QK + +  ++++Q LQ   E
Sbjct: 876  QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQE 935

Query: 268  IVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQ 327
              K   +   +++ Q+  T  +   +   +++S  K +E++       + +LHE ++ +Q
Sbjct: 936  -QKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQI-------KTQLHEERQDIQ 987

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE-------EENCLIQLKCENLQQKLEQM 380
                    QE  ++ L  +     + L+K   E       E    I+L  E      +Q+
Sbjct: 988  TDNSDIF-QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQI 1046

Query: 381  DAENKELEKKLAN--QEECLK----HSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEI 434
            D  +K+   KL    Q++ L+    H+ +     + +   L +QL+A   E R+KV   +
Sbjct: 1047 DQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME-REKVFAVL 1105

Query: 435  EKMSSRESALQI---KILDL----ETELRKKNEEQNQLVCKMNSKAQ 474
             + +   S L+    K++D+    E  L K  +E  +L  +  S  Q
Sbjct: 1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQ 1152



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 103/551 (18%), Positives = 231/551 (41%), Gaps = 67/551 (12%)

Query: 15   NLKKKVFEKEAHIQELSCLFQS-----------EKANTLKANRFSQSVKVVHERLQIQIH 63
            NL + + EK+  I  LS   Q+            +A  + +N+F + ++   ++L+ Q+ 
Sbjct: 1161 NLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQE-RDKLKQQVK 1219

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKV--YKQ- 120
            K E    ++   V++++ + A+  LQ  +++ +A V+ ++     + +     +  Y+Q 
Sbjct: 1220 KMEEWKQQVMTTVQNMQHESAQ--LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQN 1277

Query: 121  --RLDHF---TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMK 175
              +L +F      ++    Q+ + +  L   +   +   S    +  +  E    +   K
Sbjct: 1278 ETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAEC---LRASK 1334

Query: 176  KQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKD-EVVSV 234
             ++++   +L + E       EE+ + +   +    TL   N +L  ++AA  + E    
Sbjct: 1335 SEVLSESSELLQQE------LEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388

Query: 235  ENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQ-------ITKTK 287
            E   SE++++++KQ  L ++ K +   ++  ++ + S  EN  +K N+       +T  K
Sbjct: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLK 1448

Query: 288  NK------NVEKMRGQMESHLK-------ELERVCDSLTAAERRLHECQESLQCCKGKCA 334
             +      ++ K++G+ E  ++       E + + ++       L E +      K K  
Sbjct: 1449 ERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKAL 1508

Query: 335  DQEHTIRELQGQVDGNHNLLTKL--SLEEENCLIQLKCENLQQKLEQMDAENKELEKKL- 391
              E  ++E +    G  N L     S++E+  + Q + + +   L+Q   EN  L+ ++ 
Sbjct: 1509 AFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQ 1568

Query: 392  --------ANQE-ECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRES 442
                    +NQE E L++  L+ ++        A   EA L   R+KV    EK+ S  +
Sbjct: 1569 RLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL---RKKVTVLEEKLVSSSN 1625

Query: 443  ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 502
            A++        ++    E+ N +  + +  A    V  ++V+       N    ++++ Q
Sbjct: 1626 AMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ 1685

Query: 503  FLKTSYVTMFE 513
              K  Y    E
Sbjct: 1686 EEKAMYSAELE 1696



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 27/116 (23%), Positives = 56/116 (48%), Gaps = 12/116 (10%)

Query: 339 TIRELQGQVDG-NHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEEC 397
           ++  L GQ+     ++L + + E E  L   + + ++     + +EN+ L+K   + EE 
Sbjct: 22  SLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEK 81

Query: 398 LKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLET 453
            + S ++ K++S  Y    +Q E            EI  + +R+ ALQ ++L L++
Sbjct: 82  HEASEIQIKQQSTSYRNQLQQKEV-----------EISHLKARQIALQDQLLKLQS 126


>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
           sapiens]
          Length = 955

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 115/557 (20%), Positives = 253/557 (45%), Gaps = 63/557 (11%)

Query: 4   ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
           E L   +  + +++K +  K   I+EL  L++S++  T       ++++ + +++Q  I 
Sbjct: 271 EKLKLQQKHDADVQKILERKNNEIEELKTLYRSKQHET------EETIRKLEKKVQTLIR 324

Query: 64  K----REAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYK 119
                RE + D++ E  K  E      N       + A+   E  ++K    K+ ++  +
Sbjct: 325 DCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNAVA--EMEQEKFDLQKQHTENIQ 382

Query: 120 QRLDHFTGAIEKLTSQ-----------IRDQEAKLSETISASNAWKSHYEKIVIEKTELE 168
           + L+     + K+ S+           I++ EA++ +    +       +K++ EK ELE
Sbjct: 383 ELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQKLIQEKAELE 442

Query: 169 --VQIETMKKQIINLLED-LKKMEDHGKNSCEEILRKVHS-----IEYENETLNLENTKL 220
              QI   + Q +    + L K +DH  N  E+ ++ + +     I    +   L  +K 
Sbjct: 443 RCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINLLKQEHALSASKA 502

Query: 221 KTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKN 280
            + +  L+  V  ++ +L E  E+++KQ+   +  K Q++K      I + +  +L  + 
Sbjct: 503 SSMIEELEQNVCQLKQQLQE-SELQRKQQLRDQENKFQMEK-SHLKHIYEKKAHDLQSEL 560

Query: 281 NQITKTKNKNVEKMRGQMESHLKELERVCD----SLTAAERRLHECQESLQCCKGKC-AD 335
           ++  +   K + K    ++   ++L RV +        A+  L E +  ++    K  A+
Sbjct: 561 DKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAE 620

Query: 336 QEHTIRELQGQVDGNHNLLTKLSLE-----------EENCLIQLKCENLQQK---LEQMD 381
            +  + +++  +  + +L  K S E            E  +++LK E+ Q+K   L+Q +
Sbjct: 621 MKEQMEKVEADLTRSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHN 680

Query: 382 AENKEL----EKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKM 437
           AE   L    E+++ N E+ L+ +N++ + +  E+     Q+ A +E    K+ EE+  +
Sbjct: 681 AEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVIADMEAQVHKLREELINV 740

Query: 438 SSRESALQIKI-LDLETELRKKNEEQNQLVCKMNSKAQHQEVCLK-----EVQNSLEKSE 491
           +S+     +++ L  E E ++   E   +V K+ ++++  ++ LK     E + +LEK+ 
Sbjct: 741 NSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIELKKTHAAETEMTLEKAN 800

Query: 492 NQNESI-KNYLQFLKTS 507
           ++ + I K Y Q L  S
Sbjct: 801 SKLKQIEKEYTQKLAKS 817



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 108/507 (21%), Positives = 221/507 (43%), Gaps = 73/507 (14%)

Query: 10  ESENTNLKK-KVFEKEAHIQ---ELSCLFQSE---KANTLK------ANRFSQSVKVVHE 56
           E+EN+NL++ K+ +++A ++   +++C    E   + NTL        N + Q++K++  
Sbjct: 423 EAENSNLQRQKLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQT 482

Query: 57  RLQIQIHKREAEN----DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALK 112
           +    I+  + E+     K    ++ LE  + +   Q          ++E+  Q+   L+
Sbjct: 483 KYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQ----------LQESELQRKQQLR 532

Query: 113 KASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSH-YEKIVIEKTELEVQI 171
                ++    H     EK    ++ +  K  E        K H +E+ + EK E   ++
Sbjct: 533 DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQK----KIHKFEEALKEKEEQLTRV 588

Query: 172 ETMKK----QIINLLEDLKK-MEDHGKNSCEEILRKVHSIEYE-NETLNLENTKLKTTLA 225
             +++    Q    LE+ K+ +E + +    E+  ++  +E +   + +L   + K  L 
Sbjct: 589 TEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLW 648

Query: 226 ALKDEVVSVENELSELQEVEKKQKT-LIEMYKTQVQKL-----QEAAEIVKS-RCENLLH 278
            L+D     E ++ EL+   +++KT L++ +  +   L     +E   + K  R  N+ H
Sbjct: 649 QLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEH 708

Query: 279 KNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEH 338
           +N QI + K ++ + +   ME+ + +L     ++ +  ++       L+  + + A +EH
Sbjct: 709 EN-QIQEFKKRDAQVI-ADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREH 766

Query: 339 TIRELQGQVDGNHNLLTKLSLEEENCLIQLK---CENLQQKLEQMDAENKELEK----KL 391
            I            ++ KL  E E   I+LK       +  LE+ +++ K++EK    KL
Sbjct: 767 EI------------VVNKLKAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKEYTQKL 814

Query: 392 ANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDL 451
           A   + +            E +      E  L++ RQK  +E +K   R++   IK+L  
Sbjct: 815 AKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQKFEDE-KKQLIRDNDQAIKVLQD 873

Query: 452 ETELRKKNEEQNQLVCKMNSKAQHQEV 478
           E E R      NQ+ C    K QH+E+
Sbjct: 874 ELENR-----SNQVRC-AEKKLQHKEL 894



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 100/459 (21%), Positives = 196/459 (42%), Gaps = 72/459 (15%)

Query: 52  KVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVAL 111
           K   E+L++Q  K +A+  K+ E  K+ E +  K   +S+ ++ E  + K   + +T  L
Sbjct: 267 KFHEEKLKLQ-QKHDADVQKILER-KNNEIEELKTLYRSKQHETEETIRKLEKKVQT--L 322

Query: 112 KKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQI 171
            +  +V ++  +     ++K+  Q          T S +N W+      V E  + +  +
Sbjct: 323 IRDCQVIRETKEDQIAELKKICEQ---------STESLNNDWEKKLHNAVAEMEQEKFDL 373

Query: 172 ETMKKQIIN-LLED----LKKMEDH-------GKNSCEEILRKVHSIEYENETLNLENTK 219
           +    + I  LLED    L KME           +  +E+  +V  +  E E  NL+  K
Sbjct: 374 QKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARVQQLTGEAENSNLQRQK 433

Query: 220 LKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCE---NL 276
           L    A L+      +   SELQEV+ ++ TL +     V   ++  ++++++ +   NL
Sbjct: 434 LIQEKAELER---CYQITCSELQEVKARRNTLHKEKDHLVNDYEQNMKLLQTKYDADINL 490

Query: 277 LHKNNQITKTKNKNVEKMRGQMESHLKELER-VCDSLTAAERRLHECQESLQCCKGKCAD 335
           L + + ++ +K            S ++ELE+ VC       +   + QES    K +  D
Sbjct: 491 LKQEHALSASK----------ASSMIEELEQNVC-------QLKQQLQESELQRKQQLRD 533

Query: 336 QEHTIRELQGQVDGNHNLLTKLSLEEENC--LIQLKCENLQQKLEQMDAENKELEKKLAN 393
           QE+                 K  +E+ +   + + K  +LQ +L   D   ++ +KK+  
Sbjct: 534 QEN-----------------KFQMEKSHLKHIYEKKAHDLQSEL---DKGKEDTQKKIHK 573

Query: 394 QEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKI-LDLE 452
            EE LK    +    +      A+Q +AALEE +++V    EK+ +       K+  DL 
Sbjct: 574 FEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLT 633

Query: 453 TELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE 491
                + ++  + + ++    Q  E  + E++   E+ +
Sbjct: 634 RSKSLREKQSKEFLWQLEDIRQRYEQQIVELKLEHEQEK 672



 Score = 56.2 bits (134), Expect = 7e-08
 Identities = 91/410 (22%), Positives = 179/410 (43%), Gaps = 49/410 (11%)

Query: 4   ENLTDNES----ENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERL- 58
           + L D E+    E ++LK  ++EK+AH  + S L + ++    K ++F +++K   E+L 
Sbjct: 529 QQLRDQENKFQMEKSHLKH-IYEKKAHDLQ-SELDKGKEDTQKKIHKFEEALKEKEEQLT 586

Query: 59  ---QIQIHKREAENDKLKEYVKSLETKIAKW--NLQSRMNKNEAIVMKEAS-RQKT---- 108
              ++Q  + +  +  L+E+ + +E    K    ++ +M K EA + +  S R+K     
Sbjct: 587 RVTEVQRLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEF 646

Query: 109 ------VALKKASKVYKQRLDHFTGAIEKLT-------SQIRDQEAKLSETISASNAWKS 155
                 +  +   ++ + +L+H       L        S +RD E ++        A   
Sbjct: 647 LWQLEDIRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANM 706

Query: 156 HYEKIVIEKTELEVQ-IETMKKQIINLLEDLKKMEDHGKNSCEEI--LRKVHSIEYENET 212
            +E  + E  + + Q I  M+ Q+  L E+L  +    K    E+  LR+        E 
Sbjct: 707 EHENQIQEFKKRDAQVIADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREH 766

Query: 213 LNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIV--- 269
             + N KLK     +K E+       +E+  +EK    L ++ K   QKL ++++I+   
Sbjct: 767 EIVVN-KLKAESEKMKIELKKTHAAETEMT-LEKANSKLKQIEKEYTQKLAKSSQIIAEL 824

Query: 270 KSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCD-SLTAAERRLHECQESLQC 328
           ++   +L  +N+Q      + ++ +R + E   K+L R  D ++   +  L      ++C
Sbjct: 825 QTTISSLKEENSQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRC 884

Query: 329 CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLE 378
            + K    +H   E Q Q+       T +  E E  L  L   +L+Q+LE
Sbjct: 885 AEKKL---QHKELESQEQI-------TYIRQEYETKLKGLMPASLRQELE 924


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 114/514 (22%), Positives = 213/514 (41%), Gaps = 106/514 (20%)

Query: 8    DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREA 67
            D E EN  L + + E  + + ++    + EK    K     +      E L+ ++H  E 
Sbjct: 584  DIEKENKILHESIKETSSKLSKI----EFEKRQIKKELEHYKEKGERAEELENELHHLEK 639

Query: 68   ENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG 127
            EN+ L++ + +L+    K                EA  Q+   L++ ++  K+ LD F  
Sbjct: 640  ENELLQKKITNLKITCEKI---------------EALEQENSELERENRKLKKTLDSFKN 684

Query: 128  ------AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
                  ++EK  SQ+ ++  +L   + +         ++ +E  ELE + E +KK +  L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 182  LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
                KK E                +E   + L++EN +L+ TL     ++  +E   SEL
Sbjct: 745  KASFKKTE---------------RLEVSYQGLDIENQRLQKTLENSNKKIQQLE---SEL 786

Query: 242  QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
            Q++E + +TL        QK  E  +I   R E L        + +NK++E+   Q+E  
Sbjct: 787  QDLEMENQTL--------QKNLEELKISSKRLEQL--------EKENKSLEQETSQLEKD 830

Query: 302  LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 361
             K+LE+         +RL +  E       K    E    ++      N  L  ++ + +
Sbjct: 831  KKQLEK-------ENKRLRQQAEI------KDTTLEENNVKIGNLEKENKTLSKEIGIYK 877

Query: 362  ENCLIQLKCENLQQKLEQMDAENKELEKK-------LANQEECLKHSNLKFKEKSAEYTA 414
            E+C+          +L++++ ENKEL K+       L    E L    LK ++ + +   
Sbjct: 878  ESCV----------RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 415  LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 474
            L  +LE       + + +E     SR   L+ K   LE+ L+K  E + + +  + ++  
Sbjct: 928  LTHELEKIGLNKERLLHDEQSTDDSRYKLLESK---LESTLKKSLEIKEEKIAALEAR-- 982

Query: 475  HQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
                        LE+S N N+ ++  L+ +K +Y
Sbjct: 983  ------------LEESTNYNQQLRQELKTVKKNY 1004



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 112/527 (21%), Positives = 220/527 (41%), Gaps = 81/527 (15%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
           ESE +  K+++ + E +           KA   +    +Q +      L+ Q+    A +
Sbjct: 326 ESEVSRYKERLHDIEFY-----------KARVEELKEDNQVLLETKTMLEDQLEGTRARS 374

Query: 70  DKLKEYVKS---LETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 126
           DKL E  K    L+ K+    ++  M++ +     E   ++ + L+ A K       H  
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKI----EELMEENMTLEMAQKQSMDESLHLG 430

Query: 127 GAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLK 186
             +E+++        + SE   A      H    +     L++++E   + +   +E+L+
Sbjct: 431 WELEQIS--------RTSELSEAPQKSLGHEVNELTSSRLLKLEMEN--QSLTKTVEELR 480

Query: 187 KMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ---- 242
              D  + +  +IL+    +E EN+ L+ +   L+  +   K  + + +N   +L     
Sbjct: 481 TTVDSVEGNASKILK----MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536

Query: 243 EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
           ++EK  +TL E  + Q++ L++  E +     +L  ++    + + K++EK    +   +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596

Query: 303 KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 362
           KE       L+  E    + ++ L+  K K    E    EL               LE+E
Sbjct: 597 KE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-------------HLEKE 640

Query: 363 NCLIQLKCENLQ---QKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL 419
           N L+Q K  NL+   +K+E ++ EN ELE++           N K K+    +  L  QL
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERE-----------NRKLKKTLDSFKNLTFQL 689

Query: 420 EAALEEGRQKVAEEIEKMSSRES--ALQIKILDLETELRKKNEEQNQLVCKMN------S 471
           E+  +E  Q   E +E   + ES     +K+  L+ E ++   E+ QL   +        
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 472 KAQHQEVCL-------KEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
           K +  EV         + +Q +LE S  + + +++ LQ L+    T+
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 112/512 (21%), Positives = 205/512 (40%), Gaps = 63/512 (12%)

Query: 6    LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR 65
            L + E EN  L K+       +  L     SEK  T + N   +  K+ HE  +I ++K 
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE--KLTHELEKIGLNKE 940

Query: 66   EAENDKLK---EYVKSLETKIAKWNLQSRMNKNEAIVMKEAS-----------RQKTVAL 111
               +D+        K LE+K+     +S   K E I   EA            RQ+   +
Sbjct: 941  RLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 1000

Query: 112  KKASKVYKQRLDH-----------------------FTGAIEKLTSQIRDQEAKLSETIS 148
            KK  +  KQR D                         T  + K+  ++ + E   +   +
Sbjct: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1060

Query: 149  ASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEY 208
               A K+  +++  +   L+ QI  +++Q ++L E    ++                ++ 
Sbjct: 1061 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK-----------LQV 1109

Query: 209  ENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEI 268
            EN TLN ++T L    A L  +  S+ENE   + +  +  K+L +      +KL+   E 
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169

Query: 269  VKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC 328
              S  E+L+ K+  + K+ +KN+E     +E    +L +    L   E+ L   QE +  
Sbjct: 1170 QASEYESLISKHGTL-KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1228

Query: 329  CKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELE 388
                        ++L G+ D  ++  ++L  E E  ++Q   +NL+  L     E   LE
Sbjct: 1229 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--VLQTDHKNLKSLLNNSKLEQTRLE 1286

Query: 389  KKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKI 448
             + +  +E  +  ++    K      L  QL+  LEE  + + ++I+ +  +   L    
Sbjct: 1287 AEFSKLKEQYQQLDIT-STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL---- 1341

Query: 449  LDLETELRKK---NEEQNQLVCKMNSKAQHQE 477
              LE  +  K   + EQ Q + K+N   + +E
Sbjct: 1342 --LEQNMESKDLFHVEQRQYIDKLNELRRQKE 1371



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 111/525 (21%), Positives = 220/525 (41%), Gaps = 54/525 (10%)

Query: 3    LEN-LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            LEN L   E EN  L+KK+   +   +++  L Q E +   + NR  +      + L  Q
Sbjct: 630  LENELHHLEKENELLQKKITNLKITCEKIEALEQ-ENSELERENRKLKKTLDSFKNLTFQ 688

Query: 62   IHKREAENDKLKEY----------VKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVAL 111
            +   E EN +L E           +K    K+A+  L+++  ++E   +K+       + 
Sbjct: 689  LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 112  KKASKV-------------YKQRLDHFTGAIEKLTSQIRDQEAK---LSETISASNAWKS 155
            KK  ++              ++ L++    I++L S+++D E +   L + +        
Sbjct: 749  KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808

Query: 156  HYEKIVIEKTELEV---QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENET 212
              E++  E   LE    Q+E  KKQ+    + L++  +    + EE   K+ ++E EN+T
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868

Query: 213  LNLENTKLKTTLAALKDEVVSVENELSELQE---------VEKKQKTLIEMYKTQ----- 258
            L+ E    K +   LK+    +E E  EL +         V  ++  + E  KTQ     
Sbjct: 869  LSKEIGIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924

Query: 259  VQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE-LERVCDSLTAAER 317
            ++KL    E +    E LLH       ++ K +E    ++ES LK+ LE   + + A E 
Sbjct: 925  LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLES---KLESTLKKSLEIKEEKIAALEA 981

Query: 318  RLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKL 377
            RL E     Q  + +    +     L+ + D    + +   +  E+   + + +   ++L
Sbjct: 982  RLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1041

Query: 378  EQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKM 437
             ++     E+E+  A  +   +    + K+   +   L  Q+  AL+     + E+   +
Sbjct: 1042 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI-LALQRQTVSLQEQNTTL 1100

Query: 438  SSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKE 482
             ++ + LQ++   L ++      +  QL+ + +S     E  +KE
Sbjct: 1101 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 86/393 (21%), Positives = 162/393 (41%), Gaps = 60/393 (15%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            + L + E  N  L+ +    +  +++L     + +A  L   R + S++  +  LQ Q  
Sbjct: 1046 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1105

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEAS-RQKTVALKKASKVYKQRL 122
            K + EN  L     SL            MN+N  ++++++S   +  ++ K  +  K   
Sbjct: 1106 KLQVENSTLNSQSTSL------------MNQNAQLLIQQSSLENENESVIKEREDLKSLY 1153

Query: 123  DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL 182
            D      EKL      Q ++    IS     KS ++ + +E  +LE +   + KQ    L
Sbjct: 1154 DSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ-KGQL 1212

Query: 183  EDLKKMEDHGKNSCEEILRKVHSIEYEN-ETLNLENTKLKTTLAALKDEVVSVENELSEL 241
            EDL+KM    K   E++L     +E +N ET+  E  KL      L      +  E   L
Sbjct: 1213 EDLEKML---KVEQEKML-----LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264

Query: 242  QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
            Q   K  K+L+   K +  +L+     +K + + L      IT TK  N  ++  Q++ +
Sbjct: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL-----DITSTKLNNQCELLSQLKGN 1319

Query: 302  LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 361
            L+E                              +  H + ++Q  +  N  LL + ++E 
Sbjct: 1320 LEE------------------------------ENRHLLDQIQTLMLQNRTLLEQ-NMES 1348

Query: 362  ENCLIQLKCENLQQKLEQMDAENKELEKKLANQ 394
            ++ L  ++      KL ++  + ++LE+K+ +Q
Sbjct: 1349 KD-LFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 119/565 (21%), Positives = 244/565 (43%), Gaps = 77/565 (13%)

Query: 13   NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL 72
            N +LK+  F +E  + EL  L + +K    K +  +  +K   E  Q      E  N  L
Sbjct: 1144 NKSLKENTFLQE-QLVELKMLAEEDKR---KVSELTSKLKTTDEEFQSLKSSHEKSNKSL 1199

Query: 73   KEYVKSLETKIAKWNLQSRMN----KNEAIVMKEASRQKTVALKKASKVYKQ--RLDHFT 126
            ++  KSLE K     L  +++    K EA++  + +    ++  K + +  +     H T
Sbjct: 1200 ED--KSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257

Query: 127  GAIEKL----TSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL 182
              +++     T  + + EA+L +     N     +++   +  E E QI++MK  I +L+
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317

Query: 183  EDLKKMEDHG---------KNSC-----EEILRKVHSIEYENETLNLENTKLKTTLAALK 228
             + + ++  G         K SC     +E+   ++++    E L  +  ++ +    L 
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377

Query: 229  DEVVSVENELSELQEVEKKQKTLIEMYK-------TQVQKLQEAAEIVK----SRCENLL 277
            D  V ++N +S L E E    +L + Y         QVQ L    + +     S  E + 
Sbjct: 1378 DLNVQLQNSIS-LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVD 1436

Query: 278  HKNNQITKTKNK----------NVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQ 327
              +N+ ++ K K           V++++ Q+E   KE     + +   +  L +  +   
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD 1496

Query: 328  CCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQ--LKCENLQQKL----EQMD 381
            C KG+  D +  + + +  ++      T   +E E+ + Q  ++ E+L + L    +Q D
Sbjct: 1497 CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556

Query: 382  AENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQ---LEAALEEGRQK-------VA 431
             E+KEL +KL + +E  +  + + KE   +   L  Q   ++A LE  +++       V 
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616

Query: 432  EEIEKMSSRESALQIKILDLETELRKKNEE-----QNQLVCKMNSKAQH----QEVCLKE 482
             + E++ + E  L+ +      EL++K E+     + QL+ +M  K +      E  L E
Sbjct: 1617 SKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE 1676

Query: 483  VQNSLEKSENQNESIKNYLQFLKTS 507
            +   L++ E +   ++  L+ +++S
Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESS 1701



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 146/645 (22%), Positives = 281/645 (43%), Gaps = 166/645 (25%)

Query: 3   LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
           LE L        NL K+  E     +E   L  SEK                 E LQ Q+
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK-----------------EALQEQL 323

Query: 63  HKREAENDKLKEYVKSLETKI------AKWNLQSRMNKNEAIVMKEASRQKTVALKKASK 116
            +R  E +K+K+   + +TK+      AK NL  ++ +++ +V+ E  RQ    + +  +
Sbjct: 324 DERLQELEKIKDLHMAEKTKLITQLRDAK-NLIEQLEQDKGMVIAETKRQ----MHETLE 378

Query: 117 VYKQRLDHFTGAIEKLTSQ---IRDQEAK--------LSETISASNAWKSHYEKIVIEKT 165
           + ++ +      I+++T+Q   +R+Q+ K        L + +S +   +    K+   K 
Sbjct: 379 MKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKL---KA 435

Query: 166 ELEVQIETMKK----QIINLLEDLKKME----DHGKNSCEEILRKVHSIEYENETLNLE- 216
           E++ QI+T++K    + I+L ++L +++    D  K S EE + K+  + +E E    E 
Sbjct: 436 EMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL-HEKELARKEQ 494

Query: 217 --NTKLKTTLAALKDEV-VSVENELSE---------------LQEVEKKQKTLIEMYKTQ 258
               KL+T     ++++ V++E   SE               L+E+E ++K ++   + +
Sbjct: 495 ELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554

Query: 259 VQKLQEAAEIVKSR---CENLLHKNNQITKT------------KNKNVEKMRGQMESHLK 303
           ++ LQ+ AE  ++R    E+ L K+ Q  K             KNK+ +++   +E H  
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT 614

Query: 304 ELERV---CDSLTAAERRL--HECQESLQCCKGKCADQEHTI---RELQGQV---DGNHN 352
           ELE +    D+L   + ++   + Q  ++  + KC  ++ T+   +E+  Q    + N  
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEK 674

Query: 353 LLTKL----------------------SLEEENCLIQLKCENLQQKLE------------ 378
            L KL                       LEEE  +++ + + ++Q+LE            
Sbjct: 675 TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQ 734

Query: 379 QMDAENKELEKKLANQEECLKHS----NLKFKEKS---AEYTALARQLEAALEEGR---Q 428
           Q+D+  KE E  +   E+ LK       L  KE+     E+ A    LEA ++      Q
Sbjct: 735 QVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQ 794

Query: 429 KVAEEIEKMSSRESA--------------LQIKILDLETELRKKNEEQNQLVCKMNSKAQ 474
           + + +++   S +SA              LQ K+LDLETE     ++  ++      +AQ
Sbjct: 795 QASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV------EAQ 848

Query: 475 HQEVCLK------EVQNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
            ++VC +      +VQ+ +++ E QN  ++  ++ L   Y +  E
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 106/520 (20%), Positives = 230/520 (44%), Gaps = 47/520 (9%)

Query: 2   LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
           L + L   E E     K   EK +  + L    + E+  +L         K +    + +
Sbjct: 496 LTKKLQTREREFQEQMKVALEK-SQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554

Query: 62  IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQK-----TVALKKASK 116
           +   + E +  +  +  LE+ + K   +++    +  V  EA + K     TV ++K  K
Sbjct: 555 LRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK-HK 613

Query: 117 VYKQRLDH-----FTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTE---LE 168
              + L H     +T  ++ L  Q + +  KL E        K   EK  + K +    +
Sbjct: 614 TELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE--------KCEQEKETLLKDKEIIFQ 665

Query: 169 VQIETMKKQIINLLEDLKKMEDHGKNS-CEEILRKVHSIEYENETLNLENTKLKTTLAAL 227
             IE M ++ +  L D+K+ E    +S   E+L+  H +E E   L  +  K+K  L A 
Sbjct: 666 AHIEEMNEKTLEKL-DVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAK 724

Query: 228 KDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTK 287
            DE         +    +++  ++I+ ++  +Q+ ++A +   ++ E LL + ++  K  
Sbjct: 725 MDE---------QKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775

Query: 288 NKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQV 347
             +VE +   ++    EL++    L   +       E  +  + + A  +  + +L+ + 
Sbjct: 776 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835

Query: 348 DGNHNLLTKLSLEEENCLIQLKCENLQQK--LEQMDAENKELEKKLAN----QEECLKHS 401
                 + ++  ++++   +L    +Q +  ++Q++ +N E+E+K+ +     E  L+  
Sbjct: 836 ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895

Query: 402 NLKFKEKSAEYTALARQLEAALEEGRQKVAEEI-EKMSSRESALQIKILDLETELRKKNE 460
           N K +E++ +       +   + EG++K  E + +K+S++E +  I IL+ E E + KN+
Sbjct: 896 N-KEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDS--IHILNEEYETKFKNQ 952

Query: 461 EQNQLVCKMNSKAQHQEVCLKEV--QNSLEKSENQNESIK 498
           E+     K  +K + QE   K++  Q +  K E +N +++
Sbjct: 953 EKKMEKVKQKAK-EMQETLKKKLLDQEAKLKKELENTALE 991



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 116/533 (21%), Positives = 227/533 (42%), Gaps = 57/533 (10%)

Query: 3    LENLTDNES--ENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQI 60
            LE+  ++ES  +   LK+K  +K A I++   L Q E+    K  ++ +  +     L  
Sbjct: 1625 LEDRLESESAAKLAELKRKAEQKIAAIKK-QLLSQMEE----KEEQYKKGTESHLSELNT 1679

Query: 61   QIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
            ++ +RE E   L+E +KS+E+  ++  +  R  KN A   ++        ++K  +    
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739

Query: 121  RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
             L       EKL  ++  ++    ET+S+    +  Y++ +I+    E +    +  I +
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEK---EETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH 1796

Query: 181  LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENT--KLKTTLAALKDEVVSVENEL 238
            L E+L++          + + K           NLEN    ++ TL   +     +E ++
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856

Query: 239  SELQEVEKKQKTL----IEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKN------ 288
             EL     +QK +    +E   ++ +KLQ   ++        L + N   K+K+      
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPK 1916

Query: 289  --KNVEKMRGQMESHLKELERVCDSLTAAERRLH--------ECQESLQCCKGKC-ADQE 337
               N+E     +E  L   ER    L     RL         E Q+ L+  K +   ++E
Sbjct: 1917 LLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976

Query: 338  HTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ---------------QKLEQMDA 382
              I++ Q  ++  HN   K  + E N  +  K + L+               + LE    
Sbjct: 1977 EKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQE 2036

Query: 383  ENKELEKKLANQEECLKHSNLKFKE----KSAEYTALARQLEAALEEGRQKVAEEIEKMS 438
            E  +L KK+A +++ LK +  +++E    +  E TA  R L+  LEE ++K  +++E+  
Sbjct: 2037 ETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEE 2096

Query: 439  SRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE 491
            +  +   + I++L+T+L +K      L+     K Q     +  +++ L+K E
Sbjct: 2097 NPGND-NVTIMELQTQLAQK----TTLISDSKLKEQEFREQIHNLEDRLKKYE 2144



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 121/554 (21%), Positives = 232/554 (41%), Gaps = 108/554 (19%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            L + L D E+E   L K+V E EA  +++     + K                  ++Q  
Sbjct: 824  LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI-----------------QVQDL 866

Query: 62   IHKREAENDKLKEYVKSL----ETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKV 117
            + + E +N ++++ VKSL    E+K+   N +    K   +  +    Q     KK  ++
Sbjct: 867  MQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926

Query: 118  YKQRLDHFTGAI----EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIET 173
              Q+L     +I    E+  ++ ++QE K+ +    +   +   +K +++      Q   
Sbjct: 927  LTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLD------QEAK 980

Query: 174  MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVS 233
            +KK++ N   +L + E        E + + +S    +    LE T  K  + +L +    
Sbjct: 981  LKKELENTALELSQKEKQFNAKMLE-MAQANSAGISDAVSRLE-TNQKEQIESLTEVHRR 1038

Query: 234  VENELSELQEVEKKQKT--LIEMYKTQVQ-KLQEAAEIVKS----RCENLLHKNNQITKT 286
              N++  + E +  Q+   L E+++ Q+Q K QE AE+ +      CE     N +IT  
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKE-EMNKEITWL 1097

Query: 287  KNKNVEK--MRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQ 344
            K + V++     +++  LK+     +SL   E +L    E L+                 
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLE----------------- 1140

Query: 345  GQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLK 404
              VD N +L     L+E+   +++  E  ++K+ ++ ++ K  +++  + +   + SN  
Sbjct: 1141 --VDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKS 1198

Query: 405  FKEKSAEYTALARQL-----------EAALEEGRQKVAEEIEKMSSR------------- 440
             ++KS E+  L+ +L           EA LE    K  E I   SS+             
Sbjct: 1199 LEDKSLEFKKLSEELAIQLDICCKKTEALLE---AKTNELINISSSKTNAILSRISHCQH 1255

Query: 441  -----ESALQIK---ILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSEN 492
                 + AL IK   + +LE +LR+  EEQN L            +  ++  + LE+ EN
Sbjct: 1256 RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTL-----------NISFQQATHQLEEKEN 1304

Query: 493  QNESIKNYLQFLKT 506
            Q +S+K  ++ L T
Sbjct: 1305 QIKSMKADIESLVT 1318



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 86/411 (20%), Positives = 178/411 (43%), Gaps = 71/411 (17%)

Query: 112 KKASKVYKQRLDHFTGAIEKLTSQIR-DQEAK--LSETISASNAWKSHYEKIVIEKTELE 168
           KK   +  Q  D     I +L  +++ DQ+AK  L E   AS   K  Y  +      L+
Sbjct: 172 KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISV------LQ 225

Query: 169 VQIETMKKQI------INLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKT 222
            Q+  +K+++      +++L+ L ++E        E+  K  + E + E +  + T +KT
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQA-----EVFTKEENPESDGEPVVEDGTSVKT 280

Query: 223 TLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQ 282
                          L  LQ+  K+Q+ L++  K  +Q  +E   ++ S  E L      
Sbjct: 281 ---------------LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEAL------ 319

Query: 283 ITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRE 342
                       + Q++  L+ELE++ D   A + +L            +  D ++ I +
Sbjct: 320 ------------QEQLDERLQELEKIKDLHMAEKTKLIT----------QLRDAKNLIEQ 357

Query: 343 LQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 402
           L+ Q  G     TK  + E   + + +   L+ +++QM  + +EL ++    E       
Sbjct: 358 LE-QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416

Query: 403 LKFKEKSAEYTALARQLEAALEEGRQKV--AEEIEKMSSRESALQIKILDLETELRKKNE 460
            K    + +     R+L+A ++E  + +    E E++S ++   ++K  ++   ++K +E
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK-QEVVDVMKKSSE 475

Query: 461 EQNQLVCKMNSK--AQHQEVCLKEVQNSLEKSENQNESI--KNYLQFLKTS 507
           EQ   + K++ K  A+ ++   K++Q    + + Q +    K+  ++LK S
Sbjct: 476 EQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKIS 526


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 112/514 (21%), Positives = 215/514 (41%), Gaps = 107/514 (20%)

Query: 8    DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREA 67
            D E EN  L + + E  + + ++    + EK    K     +      E L+ ++H  E 
Sbjct: 584  DIEKENKILHESIKETSSKLSKI----EFEKRQIKKELEHYKEKGERAEELENELHHLEK 639

Query: 68   ENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTG 127
            EN+ L++ + +L+    K                EA  Q+   L++ ++  K+ LD F  
Sbjct: 640  ENELLQKKITNLKITCEKI---------------EALEQENSELERENRKLKKTLDSFKN 684

Query: 128  ------AIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
                  ++EK  SQ+ ++  +L   + +         ++ +E  ELE + E +KK +  L
Sbjct: 685  LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 182  LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
                KK E                +E   + L++EN +L+ TL     ++  +E   SEL
Sbjct: 745  KASFKKTE---------------RLEVSYQGLDIENQRLQKTLENSNKKIQQLE---SEL 786

Query: 242  QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
            Q++E + +TL        QK  E  +I   R E L        + +NK++E+   Q+E  
Sbjct: 787  QDLEMENQTL--------QKNLEELKISSKRLEQL--------EKENKSLEQETSQLEKD 830

Query: 302  LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 361
             K+LE+         +RL +  E       K    E    ++      N  L  ++ + +
Sbjct: 831  KKQLEK-------ENKRLRQQAEI------KDTTLEENNVKIGNLEKENKTLSKEIGIYK 877

Query: 362  ENCLIQLKCENLQQKLEQMDAENKELEKK-------LANQEECLKHSNLKFKEKSAEYTA 414
            E+C+          +L++++ ENKEL K+       L    E L    LK ++ + +   
Sbjct: 878  ESCV----------RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927

Query: 415  LARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQ 474
            L  +LE  +   ++++  + +    R   L+ K   LE+ L+K  E + + +  + ++  
Sbjct: 928  LTHELE-KIGLNKERLLHDEQSTDDRYKLLESK---LESTLKKSLEIKEEKIAALEAR-- 981

Query: 475  HQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
                        LE+S N N+ ++  L+ +K +Y
Sbjct: 982  ------------LEESTNYNQQLRQELKTVKKNY 1003



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 112/511 (21%), Positives = 206/511 (40%), Gaps = 62/511 (12%)

Query: 6    LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR 65
            L + E EN  L K+       +  L     SEK  T + N   +  K+ HE  +I ++K 
Sbjct: 883  LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE--KLTHELEKIGLNKE 940

Query: 66   EAENDKLK--EYVKSLETKIAKWNLQSRMNKNEAIVMKEAS-----------RQKTVALK 112
               +D+    +  K LE+K+     +S   K E I   EA            RQ+   +K
Sbjct: 941  RLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1000

Query: 113  KASKVYKQRLDH-----------------------FTGAIEKLTSQIRDQEAKLSETISA 149
            K  +  KQR D                         T  + K+  ++ + E   +   + 
Sbjct: 1001 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1060

Query: 150  SNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYE 209
              A K+  +++  +   L+ QI  +++Q ++L E    ++                ++ E
Sbjct: 1061 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK-----------LQVE 1109

Query: 210  NETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIV 269
            N TLN ++T L    A L  +  S+ENE   + +  +  K+L +      +KL+   E  
Sbjct: 1110 NSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQ 1169

Query: 270  KSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCC 329
             S  E+L+ K+  + K+ +KN+E     +E    +L +    L   E+ L   QE +   
Sbjct: 1170 ASEYESLISKHGTL-KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE 1228

Query: 330  KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEK 389
                       ++L G+ D  ++  ++L  E E  ++Q   +NL+  L     E   LE 
Sbjct: 1229 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--VLQTDHKNLKSLLNNSKLEQTRLEA 1286

Query: 390  KLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKIL 449
            + +  +E  +  ++    K      L  QL+  LEE  + + ++I+ +  +   L     
Sbjct: 1287 EFSKLKEQYQQLDIT-STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL----- 1340

Query: 450  DLETELRKK---NEEQNQLVCKMNSKAQHQE 477
             LE  +  K   + EQ Q + K+N   + +E
Sbjct: 1341 -LEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 112/527 (21%), Positives = 220/527 (41%), Gaps = 81/527 (15%)

Query: 10  ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
           ESE +  K+++ + E +           KA   +    +Q +      L+ Q+    A +
Sbjct: 326 ESEVSRYKERLHDIEFY-----------KARVEELKEDNQVLLETKTMLEDQLEGTRARS 374

Query: 70  DKLKEYVKS---LETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFT 126
           DKL E  K    L+ K+    ++  M++ +     E   ++ + L+ A K       H  
Sbjct: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKI----EELMEENMTLEMAQKQSMDESLHLG 430

Query: 127 GAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLK 186
             +E+++        + SE   A      H    +     L++++E   + +   +E+L+
Sbjct: 431 WELEQIS--------RTSELSEAPQKSLGHEVNELTSSRLLKLEMEN--QSLTKTVEELR 480

Query: 187 KMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ---- 242
              D  + +  +IL+    +E EN+ L+ +   L+  +   K  + + +N   +L     
Sbjct: 481 TTVDSVEGNASKILK----MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536

Query: 243 EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
           ++EK  +TL E  + Q++ L++  E +     +L  ++    + + K++EK    +   +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596

Query: 303 KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEE 362
           KE       L+  E    + ++ L+  K K    E    EL               LE+E
Sbjct: 597 KE---TSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-------------HLEKE 640

Query: 363 NCLIQLKCENLQ---QKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL 419
           N L+Q K  NL+   +K+E ++ EN ELE++           N K K+    +  L  QL
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERE-----------NRKLKKTLDSFKNLTFQL 689

Query: 420 EAALEEGRQKVAEEIEKMSSRES--ALQIKILDLETELRKKNEEQNQLVCKMN------S 471
           E+  +E  Q   E +E   + ES     +K+  L+ E ++   E+ QL   +        
Sbjct: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749

Query: 472 KAQHQEVCL-------KEVQNSLEKSENQNESIKNYLQFLKTSYVTM 511
           K +  EV         + +Q +LE S  + + +++ LQ L+    T+
Sbjct: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL 796



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 113/525 (21%), Positives = 222/525 (42%), Gaps = 55/525 (10%)

Query: 3    LEN-LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            LEN L   E EN  L+KK+   +   +++  L Q E +   + NR  +      + L  Q
Sbjct: 630  LENELHHLEKENELLQKKITNLKITCEKIEALEQ-ENSELERENRKLKKTLDSFKNLTFQ 688

Query: 62   IHKREAENDKLKEY----------VKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVAL 111
            +   E EN +L E           +K    K+A+  L+++  ++E   +K+       + 
Sbjct: 689  LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 112  KKASKV-------------YKQRLDHFTGAIEKLTSQIRDQEAK---LSETISASNAWKS 155
            KK  ++              ++ L++    I++L S+++D E +   L + +        
Sbjct: 749  KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808

Query: 156  HYEKIVIEKTELEV---QIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENET 212
              E++  E   LE    Q+E  KKQ+    + L++  +    + EE   K+ ++E EN+T
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868

Query: 213  LNLENTKLKTTLAALKDEVVSVENELSELQE---------VEKKQKTLIEMYKTQ----- 258
            L+ E    K +   LK+    +E E  EL +         V  ++  + E  KTQ     
Sbjct: 869  LSKEIGIYKESCVRLKE----LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924

Query: 259  VQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKE-LERVCDSLTAAER 317
            ++KL    E +    E LLH + Q T  + K +E    ++ES LK+ LE   + + A E 
Sbjct: 925  LEKLTHELEKIGLNKERLLH-DEQSTDDRYKLLES---KLESTLKKSLEIKEEKIAALEA 980

Query: 318  RLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKL 377
            RL E     Q  + +    +     L+ + D    + +   +  E+   + + +   ++L
Sbjct: 981  RLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL 1040

Query: 378  EQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKM 437
             ++     E+E+  A  +   +    + K+   +   L  Q+  AL+     + E+   +
Sbjct: 1041 LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI-LALQRQTVSLQEQNTTL 1099

Query: 438  SSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKE 482
             ++ + LQ++   L ++      +  QL+ + +S     E  +KE
Sbjct: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 86/393 (21%), Positives = 162/393 (41%), Gaps = 60/393 (15%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            + L + E  N  L+ +    +  +++L     + +A  L   R + S++  +  LQ Q  
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEAS-RQKTVALKKASKVYKQRL 122
            K + EN  L     SL            MN+N  ++++++S   +  ++ K  +  K   
Sbjct: 1105 KLQVENSTLNSQSTSL------------MNQNAQLLIQQSSLENENESVIKEREDLKSLY 1152

Query: 123  DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLL 182
            D      EKL      Q ++    IS     KS ++ + +E  +LE +   + KQ    L
Sbjct: 1153 DSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ-KGQL 1211

Query: 183  EDLKKMEDHGKNSCEEILRKVHSIEYEN-ETLNLENTKLKTTLAALKDEVVSVENELSEL 241
            EDL+KM    K   E++L     +E +N ET+  E  KL      L      +  E   L
Sbjct: 1212 EDLEKML---KVEQEKML-----LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263

Query: 242  QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESH 301
            Q   K  K+L+   K +  +L+     +K + + L      IT TK  N  ++  Q++ +
Sbjct: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL-----DITSTKLNNQCELLSQLKGN 1318

Query: 302  LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEE 361
            L+E                              +  H + ++Q  +  N  LL + ++E 
Sbjct: 1319 LEE------------------------------ENRHLLDQIQTLMLQNRTLLEQ-NMES 1347

Query: 362  ENCLIQLKCENLQQKLEQMDAENKELEKKLANQ 394
            ++ L  ++      KL ++  + ++LE+K+ +Q
Sbjct: 1348 KD-LFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 128/587 (21%), Positives = 242/587 (41%), Gaps = 119/587 (20%)

Query: 6    LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRF----SQSVKVVHERLQ-- 59
            + D ++  + L+KK+ E +A I+EL    ++E+    K  +     S+ ++ + ERL+  
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153

Query: 60   -----IQIH---KREAENDKLKEYVKSLETK-------IAKWNLQSRMNKNEAIVMKEAS 104
                 +QI    KREAE  K++  ++    +       + K +  S     E I   +  
Sbjct: 1154 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213

Query: 105  RQKTVALKKASKVYKQRLDHFTGAIEK--------------LTSQIRDQEAKLSETISAS 150
            +QK   L+K    +K  LD  T  +E+              L  Q+ +  +K  ET  + 
Sbjct: 1214 KQK---LEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270

Query: 151  NAWKSHYEKIVIEKTELEVQIETMKKQIINL----------LEDLKKM---EDHGKNSCE 197
            N   S   K+  E  EL  Q++  +  I  L          LEDLK+    E   KN+  
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330

Query: 198  EILRKVHSI------EYENETLNLENTKLKTTLAALKDEVVSVENE-----LSELQEVEK 246
              L+           +YE ET      +L+  L+    EV     +     +   +E+E+
Sbjct: 1331 HALQSARHDCDLLREQYEEETE--AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1388

Query: 247  KQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELE 306
             +K L +    ++Q+ +EA E V ++C +L        KTK++    ++ ++E  + ++E
Sbjct: 1389 AKKKLAQ----RLQEAEEAVEAVNAKCSSL-------EKTKHR----LQNEIEDLMVDVE 1433

Query: 307  RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLI 366
            R   +  A +++     + L   K K  + +  +   Q +       L KL    E  L 
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493

Query: 367  QLKC-----ENLQQKL---------------------EQMDAENKELEKKLANQEECLKH 400
             L+      +NLQ+++                     +Q++AE  EL+  L   E  L+H
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1553

Query: 401  SNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILD-----LETEL 455
               K      E+  +  ++E       +K+AE+ E+M   +    ++++D     L+ E 
Sbjct: 1554 EEGKILRAQLEFNQIKAEIE-------RKLAEKDEEMEQAKRN-HLRVVDSLQTSLDAET 1605

Query: 456  RKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 502
            R +NE   ++  KM       E+ L        +++ Q +S+++ L+
Sbjct: 1606 RSRNEAL-RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 140/575 (24%), Positives = 256/575 (44%), Gaps = 103/575 (17%)

Query: 10   ESENTNLKKKVFEKEAHIQELSC--LFQSEKANTLKANRFSQSVKVVHERLQIQIHKREA 67
            ++EN  L +++ EKEA I +L+   L  +++   LK  +  + VK  +  L   +     
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK-RQLEEEVKAKNA-LAHALQSARH 1338

Query: 68   ENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQR 121
            + D L+E  +  ET+ AK  LQ  ++K  + V +  ++      Q+T  L++A K   QR
Sbjct: 1339 DCDLLREQYEE-ETE-AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396

Query: 122  LDHFTGAIE--------------KLTSQIRDQEAKLSETISASNAW---KSHYEKIVIE- 163
            L     A+E              +L ++I D    +  + +A+ A    + +++KI+ E 
Sbjct: 1397 LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEW 1456

Query: 164  ---KTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKL 220
                 E + ++E+ +K+  +L  +L K+    KN+ EE L  + + + EN+ L  E + L
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKL----KNAYEESLEHLETFKRENKNLQEEISDL 1512

Query: 221  KTTLAA-------LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRC 273
               L +       L+     +E E  ELQ   ++ +  +E  + ++ + Q     +K+  
Sbjct: 1513 TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI 1572

Query: 274  EN-LLHKNNQITKTKNKNVE--------------------KMRGQMESHLKELERVCDSL 312
            E  L  K+ ++ + K  ++                     +++ +ME  L E+E     L
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI---QL 1629

Query: 313  TAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL-EEENCLIQLKCE 371
            + A R   E Q+ ++  +    D   T  +L   V  N +L   +++ E  N L+Q + E
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKD---TQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686

Query: 372  NLQQKLEQMDAENKELEKKLANQEE--CLKHS------NLKFKEKSAEYTALARQLEAAL 423
             L+  +EQ +   K  E++L    E   L HS      N K K+  A+ + L  ++E A+
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK-KKMDADLSQLQTEVEEAV 1745

Query: 424  EEGRQKVAEEIEKMSSRESALQIKILDLE------TELRKKNEEQ------------NQL 465
            +E R   AEE  K +  ++A+  + L  E       E  KKN EQ             Q+
Sbjct: 1746 QECRN--AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1803

Query: 466  VCKMNSK-AQHQEVCLKEVQNSLEKSENQN-ESIK 498
              K   K  Q  E  ++E++N LE  + +N ES+K
Sbjct: 1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVK 1838



 Score = 79.3 bits (194), Expect = 8e-15
 Identities = 99/443 (22%), Positives = 192/443 (43%), Gaps = 42/443 (9%)

Query: 74   EYVKSLETK----IAKWNLQSRMNKNE----AIVMKEASRQKTVALKKASKVYKQRLDHF 125
            EY K LE +    + +WN+++ M         +  K     K+   +K     K+     
Sbjct: 800  EYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRL 859

Query: 126  TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 185
              A+EK  ++ ++ E K+   +   N  +   +       + E + + + K  I L   +
Sbjct: 860  KEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKV 919

Query: 186  KKMEDHGKNSCE---EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 242
            K+M +  ++  E   E+  K   +E E   L  +   L+ TLA ++ E  + EN++  L 
Sbjct: 920  KEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLT 979

Query: 243  EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
            E       +I     + + LQEA +      +    K N +TK K K +E+    +E  L
Sbjct: 980  EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVK-LEQQVDDLEGSL 1038

Query: 303  KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLS--LE 360
            ++ ++V   L  A+R+L   +  L+  +    D E+  ++L  ++      L  L+  +E
Sbjct: 1039 EQEKKVRMDLERAKRKL---EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIE 1095

Query: 361  EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
            +E  L       LQ+KL+++ A  +ELE++L    E  + +  K ++  ++ +    ++ 
Sbjct: 1096 DEQAL----GSQLQKKLKELQARIEELEEEL----EAERTARAKVEKLRSDLSRELEEIS 1147

Query: 421  AALEEGRQKVAEEIEKMSSRESALQIKILDLE----------TELRKKNEEQNQLVCKMN 470
              LEE     + +IE    RE+  Q    DLE            LRKK+ +    V ++ 
Sbjct: 1148 ERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS---VAELG 1204

Query: 471  SKAQHQEVCLKEVQNSLEKSENQ 493
             +  +    L+ V+  LEK +++
Sbjct: 1205 EQIDN----LQRVKQKLEKEKSE 1223



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 67/332 (20%), Positives = 137/332 (41%), Gaps = 46/332 (13%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L+  T + +E   +KKK+   E  + E+            +A +  +S++ + +  QIQ+
Sbjct: 1601 LDAETRSRNEALRVKKKM---EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMK-EASRQ--------------- 106
                  ND LKE +  +E +     LQ+ + +  A+V + E SR+               
Sbjct: 1658 DDAVRANDDLKENIAIVERRNNL--LQAELEELRAVVEQTERSRKLAEQELIETSERVQL 1715

Query: 107  ---KTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIE 163
               +  +L    K     L      +E+   + R+ E K  + I+ +       +K    
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKK---- 1771

Query: 164  KTELEVQIETMKKQIINLLEDLKKMEDH--------GKNSCEEILRKVHSIEYENET--- 212
            + +    +E MKK +   ++DL+   D         GK   +++  +V  +E E E    
Sbjct: 1772 EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQK 1831

Query: 213  LNLENTK-LKTTLAALKDEVVSVENE---LSELQEVEKKQKTLIEMYKTQVQKLQEAAEI 268
             N E+ K ++ +   +K+     E +   L  LQ++  K +  ++ YK Q ++ +E A  
Sbjct: 1832 RNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1891

Query: 269  VKSRCENLLHKNNQITKTKN---KNVEKMRGQ 297
              S+   + H+ ++  +  +     V K+R +
Sbjct: 1892 NLSKFRKVQHELDEAEERADIAESQVNKLRAK 1923


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 108/549 (19%), Positives = 244/549 (44%), Gaps = 67/549 (12%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANR----FSQSVKVVHER 57
            L   + D ++     +KK+ E +A I+EL    ++E+A   K  +    +++ ++ + ER
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSER 1150

Query: 58   L---------QIQIH-KREAENDKLKEYV-------KSLETKIAKWNLQSRMNKNEAIVM 100
            L         QI+++ KREAE  KL+  +       +++   + K +  S     E I  
Sbjct: 1151 LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN 1210

Query: 101  KEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQ-------IRDQEAKLSETISASNAW 153
             +  +QK   L+K    +K  +D  + ++E ++          R  E +LSE    +   
Sbjct: 1211 LQRVKQK---LEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267

Query: 154  KSHYEKIVIEKTELEVQIETMKKQI---INLLEDLKKMEDHGKNSCEEILRKVHSIEYEN 210
            +    ++  +K+ L+ +   + +Q+    +++  L + +       EE+ R+   +E EN
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ---LEEEN 1324

Query: 211  ETLNLENTKLKTT---LAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQ-----VQKL 262
            +  N     L+++      L+++    +   +ELQ    K  + +  ++T+     +Q+ 
Sbjct: 1325 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1384

Query: 263  QEAAEIVKSRCENLLHKNNQITKTK------NKNVEKMRGQMESHLKELERVCDSLTAAE 316
            +E  E  K   + L     Q+           K  ++++G++E  + ++ER      A +
Sbjct: 1385 EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444

Query: 317  RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK 376
            ++     + L   K KC   E +  EL+  +  + +L T+L        ++   E    +
Sbjct: 1445 KKQRNFDKVLAEWKTKC---EESQAELEASLKESRSLSTEL------FKLKNAYEEALDQ 1495

Query: 377  LEQMDAENKELEKKLANQEECLKHS--NLKFKEKSAEYTALAR-QLEAALEEGRQKVAEE 433
            LE +  ENK LE+++A+  E +  +   +   EKS +   L +  ++ ALEE    +  E
Sbjct: 1496 LETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555

Query: 434  IEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQ 493
              K+      +Q+++  +++E+ +K  E+++ + ++    Q     ++   ++  +S N+
Sbjct: 1556 EAKI----LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNE 1611

Query: 494  NESIKNYLQ 502
               +K  ++
Sbjct: 1612 AIRLKKKME 1620



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 119/569 (20%), Positives = 246/569 (43%), Gaps = 81/569 (14%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
            ++E   L +++ EKE+ + +LS   Q+    T +  R  +        L   +     + 
Sbjct: 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC 1341

Query: 70   DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQRLD 123
            D L+E  +  E +  K  LQ  ++K  + V +  ++      Q+T  L++A K   QRL 
Sbjct: 1342 DLLREQYE--EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399

Query: 124  HFT----------GAIEKLTSQIRDQEAKLSETISASNAWKS-------HYEKIVIE-KT 165
                          ++EK   +++ +   L   +  +N+  +       +++K++ E KT
Sbjct: 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKT 1459

Query: 166  ELE---VQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKT 222
            + E    ++E   K+  +L  +L K+    KN+ EE L ++ +++ EN+ L  E   L  
Sbjct: 1460 KCEESQAELEASLKESRSLSTELFKL----KNAYEEALDQLETVKRENKNLEQEIADLTE 1515

Query: 223  TLAA-------LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCEN 275
             +A        L+     +E E +++Q   ++ +  +E  + ++ ++Q     VKS  + 
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR 1575

Query: 276  LLHKNN----QITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKG 331
             + + +    Q+ +   + VE M+  +++ ++            E  L+E +  L     
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 1635

Query: 332  KCADQEHTIRELQGQVD-----------GNHNLLTKLSLEEENC-LIQLKCENLQQKLEQ 379
            + A+    +R +QGQ+            G  +L  +L++ E    L+Q + E L+  LEQ
Sbjct: 1636 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695

Query: 380  MDAENKELEKKLANQEE----------CLKHSNLKFK----EKSAEYTALARQLEAALEE 425
             +   K  E++L +  E           L H+  K +    +  +E    +R    A E+
Sbjct: 1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755

Query: 426  GRQKV------AEEIEKMSSRESALQIKILDLE---TELRKKNEEQNQLVCKMNSK-AQH 475
             ++ +      AEE++K     + L+    +LE    +L+ + +E  QL  K   K  Q 
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1815

Query: 476  QEVCLKEVQNSLEKSENQN-ESIKNYLQF 503
             E  ++E++  LE  + +N ES+K   ++
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKY 1844



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 118/537 (21%), Positives = 225/537 (41%), Gaps = 93/537 (17%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            E++ D E++   L +++ +K+    +L    + E+   L+  +  + ++   E L+ +I 
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124

Query: 64   KREAENDKLK----EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYK 119
               A   K +    +Y + LE       L  R+ +   +   +    K    K+ ++  K
Sbjct: 1125 AERATRAKTEKQRSDYARELE------ELSERLEEAGGVTSTQIELNK----KREAEFLK 1174

Query: 120  QR--LDHFTGAIEKLTSQIR----DQEAKLSETISASNAWKSHYEKIVIEKTELEVQI-- 171
             R  L+  T   E + + +R    D  A+L E I      K   EK   EK+E +++I  
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEK---EKSEFKLEIDD 1231

Query: 172  -----ETMKKQIINLLEDLKKMEDH-----GKNSCEEILRKVHSIEYENETLNLENTKLK 221
                 E++ K   NL +  + +ED      GKN  EEI R +  +  +   L  E  +L 
Sbjct: 1232 LSSSMESVSKSKANLEKICRTLEDQLSEARGKN--EEIQRSLSELTTQKSRLQTEAGELS 1289

Query: 222  TTLAALKDEVVSVENELSE-----LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENL 276
              L    +E  S+ ++LS       Q+ E+ ++ L E  K +   L  A +  +  C+ L
Sbjct: 1290 RQL----EEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK-NALAHALQSSRHDCDLL 1344

Query: 277  LHKNNQITKTK----------NKNVEKMRGQMESH-LKELERVCDSLTAAERRLHECQES 325
              +  +  + K          N  V + R + E+  ++  E + ++     +RL + +E 
Sbjct: 1345 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQ 1404

Query: 326  LQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENK 385
            ++    KCA  E T + LQG+V                       E+L   +E+ ++   
Sbjct: 1405 VEAVNAKCASLEKTKQRLQGEV-----------------------EDLMVDVERANSLAA 1441

Query: 386  ELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQ 445
             L+KK  N ++ L     K +E  AE       LEA+L+E R    E  +  ++ E AL 
Sbjct: 1442 ALDKKQRNFDKVLAEWKTKCEESQAE-------LEASLKESRSLSTELFKLKNAYEEALD 1494

Query: 446  IKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 502
                 LET ++++N+   Q +  +  +       + E++ S ++ E +   I+  L+
Sbjct: 1495 ----QLET-VKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 96/471 (20%), Positives = 196/471 (41%), Gaps = 65/471 (13%)

Query: 71   KLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIE 130
            K+K  +KS ET+     ++    K +  + K  +++K +  K  + V  Q  +     ++
Sbjct: 836  KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLV--QEKNDLQLQVQ 893

Query: 131  KLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMED 190
              +  + D E +  + I A                  + Q+E   K++    ED +++  
Sbjct: 894  AESENLLDAEERCDQLIKA------------------KFQLEAKIKEVTERAEDEEEIN- 934

Query: 191  HGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKT 250
                   E+  K   +E E   L  +   L+ TLA ++ E  + EN++  L E       
Sbjct: 935  ------AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988

Query: 251  LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNK---NVEKMRGQMESHLK---E 304
             I     + + LQEA +      +    K N + KTK+K    VE +   +E   K   +
Sbjct: 989  TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD 1048

Query: 305  LER----VCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
            LER    +   L  A+  + + +   Q    +   ++    +LQ +V+    L   L  +
Sbjct: 1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTL--GLQFQ 1106

Query: 361  EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKF--------------K 406
            ++   +Q + E L++++E   A   + EK+ ++    L+  + +               K
Sbjct: 1107 KKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166

Query: 407  EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLV 466
            ++ AE+  L R LE A  +    VA   +K +   + L  +I +L+   +K  +E+++  
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226

Query: 467  CKMN-----------SKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKT 506
             +++           SKA  +++C + +++ L ++  +NE I+  L  L T
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKIC-RTLEDQLSEARGKNEEIQRSLSELTT 1276



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 57/269 (21%), Positives = 115/269 (42%), Gaps = 24/269 (8%)

Query: 24   EAHIQEL-SCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETK 82
            +A ++EL + L Q+E+A  L       S    +ER+Q+ +H    +N  L    K LET 
Sbjct: 1683 QAEVEELRATLEQTERARKLAEQELLDS----NERVQL-LH---TQNTSLIHTKKKLETD 1734

Query: 83   IAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD---HFTGAIEKLTSQIRDQ 139
            + +   +      +A   +E +++        ++  K+  D   H     + L   ++D 
Sbjct: 1735 LMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1794

Query: 140  EAKLSETIS-ASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEE 198
            + +L E    A    K   +K+     ELE ++E  +K+    ++ L+K E         
Sbjct: 1795 QHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE--------- 1845

Query: 199  ILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQ 258
              R+V  + Y++E       +L+  +  L+ +V S + +  E  E      T     + +
Sbjct: 1846 --RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHE 1903

Query: 259  VQKLQEAAEIVKSRCENLLHKNNQITKTK 287
            +++ +E A+I +S+   L  K    T ++
Sbjct: 1904 LEEAEERADIAESQVNKLRAKTRDFTSSR 1932


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 109/505 (21%), Positives = 230/505 (45%), Gaps = 49/505 (9%)

Query: 10   ESENTNLKKKVFEKEAHIQELS-CLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAE 68
            E E + L+ +V +  A+++ L+     +EK      ++ S++ K+  E LQ Q+     +
Sbjct: 1267 EKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEA-KIKVEELQRQLADASTQ 1325

Query: 69   NDKLK----EYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDH 124
              +L+    E  + LE K    +  SR     A  ++E  RQ    L++ SK  K  L H
Sbjct: 1326 RGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQ----LEEESKA-KSALAH 1380

Query: 125  FTGAIEKLTSQIRDQ-------EAKLSETISASNA----WKSHYEKIVIEKTELEVQIET 173
               A+      +R+Q       +A+L   +S +NA    W+S YE   I++TE   ++E 
Sbjct: 1381 AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE---ELEE 1437

Query: 174  MKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVS 233
             KK++   L++ ++  +     C  + +    ++ E+E + LE  +  +  AAL  +   
Sbjct: 1438 AKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRH 1497

Query: 234  VENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEK 293
            +E  L E +  E++ +  +E  + + + L      ++   E  L     + K +NKN++ 
Sbjct: 1498 LERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETL-KRENKNLQ- 1555

Query: 294  MRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNL 353
                     +E+  + D ++ + + + E +++ +  +G+ ++ +  + E +G ++     
Sbjct: 1556 ---------EEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 1606

Query: 354  LTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYT 413
              ++ LE    L Q+K E + +KL + D E   L +      E L+ S         E  
Sbjct: 1607 TLRIQLE----LSQVKAE-VDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL 1661

Query: 414  ALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKA 473
             L +++E  L +   ++     + +  ++A ++    L+ E   ++EEQ +L  +++ +A
Sbjct: 1662 RLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ-RLAAELHEQA 1720

Query: 474  QHQE-------VCLKEVQNSLEKSE 491
            Q  E         L+E++ +LE+ E
Sbjct: 1721 QALERRASLLAAELEELRAALEQGE 1745



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 97/517 (18%), Positives = 203/517 (39%), Gaps = 62/517 (11%)

Query: 8    DNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREA 67
            D +     ++KK+ E +A  +EL    ++E+A   +  +         E L  ++ +   
Sbjct: 1145 DEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGG 1204

Query: 68   ENDKLKEYVKSLETKIAKW--NLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHF 125
             +   +E  +  E ++ +    L+    ++EA V     +Q   A +   +V    L   
Sbjct: 1205 ASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV--DSLQRV 1262

Query: 126  TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIV----IEKTELEVQIETMKKQIINL 181
               +EK  S++R +   L+  +      K+  EK+      + +E ++++E +++Q    
Sbjct: 1263 RQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQ---- 1318

Query: 182  LEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSEL 241
            L D        +    E+ R +     E E L  + ++ K   A       S+E    +L
Sbjct: 1319 LADASTQRGRLQTESGELSRLLE----EKECLISQLSRGKALAAQ------SLEELRRQL 1368

Query: 242  QEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITK---TKNKNVEKMRGQM 298
            +E  K +  L       VQ L+   ++++ + E       ++ +     N  V + R + 
Sbjct: 1369 EEESKAKSALAH----AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKY 1424

Query: 299  ESH-LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKL 357
            E+  ++  E + ++      RL E +E ++    KC+                       
Sbjct: 1425 EADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCS----------------------- 1461

Query: 358  SLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALAR 417
            SLE+    +Q + E++  +LE+  +    L+KK  + E  L+    + +E   E  A  R
Sbjct: 1462 SLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQR 1521

Query: 418  QLEA------ALEEGRQKVAEEIEKMSSRESALQIKILDLETELR---KKNEEQNQLVCK 468
            +          L  G ++  E +E +      LQ +I DL  ++    K  +E  +    
Sbjct: 1522 ESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKA 1581

Query: 469  MNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK 505
            +  +    +  L+E + +LE  E +   I+  L  +K
Sbjct: 1582 LEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK 1618



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 82/392 (20%), Positives = 164/392 (41%), Gaps = 43/392 (10%)

Query: 132  LTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLED---LKKM 188
            L +++R     L+   +     +  +  I  EK +L +Q++  +  + +  E    L K 
Sbjct: 901  LRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKS 960

Query: 189  EDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQ 248
            +   +   +E+  ++   E  N  L     KL+     LK ++  ++  L++ ++ ++  
Sbjct: 961  KVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQAT 1020

Query: 249  KTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERV 308
            +  ++    ++  L E+                ++TK K K +++   Q    L+  E  
Sbjct: 1021 ENKVKNLTEEMAALDESVA--------------RLTKEK-KALQEAHQQALGDLQAEEDR 1065

Query: 309  CDSLTAAERRLHECQESLQCC----KGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENC 364
              +LT A+ RL +  E L+C     K    D E   R+L+G +        KL+ E    
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL--------KLTQESVAD 1117

Query: 365  LIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE---- 420
              Q K + L++KL++ D+E  +L  ++ +++        K KE  A    L  +LE    
Sbjct: 1118 AAQDK-QQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERA 1176

Query: 421  --AALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEV 478
              A +E+ R + A E+E++S R               RK+  E  +L  ++   A   E 
Sbjct: 1177 ARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEA 1236

Query: 479  CL-----KEVQNSLEKSENQNESIKNYLQFLK 505
             +     K+ + + E  E Q +S++   Q L+
Sbjct: 1237 TVAALRRKQAEGAAELGE-QVDSLQRVRQKLE 1267



 Score = 60.1 bits (144), Expect = 5e-09
 Identities = 90/462 (19%), Positives = 194/462 (41%), Gaps = 58/462 (12%)

Query: 94   KNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAW 153
            KN+  +  +A +      ++   +  +      G +++L+ ++ D+E      ++A  A 
Sbjct: 933  KNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEE-----VNADLA- 986

Query: 154  KSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEIL---RKVHSIEYEN 210
             +   K+  E TEL+  I+ +K  +    ++ +  E+  KN  EE+      V  +  E 
Sbjct: 987  -ARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045

Query: 211  ETLNLENTKLKTTLAALKDEV-------VSVENELSELQ---EVEKKQKTLIEMYKTQV- 259
            + L   + +    L A +D V       + +E ++ +L+   E EKK +   E  K ++ 
Sbjct: 1046 KALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLE 1105

Query: 260  -------QKLQEAAEIVKSRCENLLHKNNQITK--TKNKNVEKMRGQMESHLKELE---- 306
                   + + +AA+  +   E L  K++++++   + ++ + +  QM+  +KEL+    
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165

Query: 307  --------------RVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHN 352
                          RV      A R L E  E L+   G  A Q    R+ + ++     
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR 1225

Query: 353  LLTKLSLEEENCLIQLK------CENLQQKLEQMDAENKELEK---KLANQEECLKHSNL 403
             L + +L  E  +  L+         L ++++ +    ++LEK   +L  + + L  +  
Sbjct: 1226 ELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVE 1285

Query: 404  KFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQN 463
                  A    L R  E  L E + KV EE+++  +  S  + ++     EL +  EE+ 
Sbjct: 1286 TLTRAKASAEKLCRTYEDQLSEAKIKV-EELQRQLADASTQRGRLQTESGELSRLLEEKE 1344

Query: 464  QLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLK 505
             L+ +++         L+E++  LE+      ++ + +Q L+
Sbjct: 1345 CLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALR 1386



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 38/156 (24%), Positives = 74/156 (47%), Gaps = 16/156 (10%)

Query: 353  LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEK----------KLANQEECLKHSN 402
            LL     EEE   ++ +   L+  L   +A+ +ELE+           LA Q +  +  N
Sbjct: 888  LLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQA-EQDN 946

Query: 403  LKFKEKSAEYTALAR-QLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEE 461
            L   E+       ++ QLE  ++E  +++ +E E++++  +A + K+ D  TEL+K  ++
Sbjct: 947  LADAEERCHLLIKSKVQLEGKVKELSERLEDE-EEVNADLAARRRKLEDECTELKKDIDD 1005

Query: 462  QNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESI 497
                + K   + Q  E    +V+N  E+    +ES+
Sbjct: 1006 LKLTLAKAEKEKQATE---NKVKNLTEEMAALDESV 1038


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 110/505 (21%), Positives = 212/505 (41%), Gaps = 58/505 (11%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            E L + E    NL+K++    A + ++    +        A    + ++   E L  +  
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD 123
            ++ A  DKL++          K  LQ  ++  + +V  +  RQ    L+K  K + Q L 
Sbjct: 1403 EKVAAYDKLEK---------TKTRLQQELD--DLLVDLDHQRQSACNLEKKQKKFDQLLA 1451

Query: 124  HFTGAIEKLTSQIRDQ---EAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
                   K   + RD+   EA+  ET + S A      + + E  E + ++E + KQ   
Sbjct: 1452 EEKTISAKYAEE-RDRAEAEAREKETKALSLA------RALEEAMEQKAELERLNKQFRT 1504

Query: 181  LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSE 240
             +EDL   +D       ++ + VH +E     L  +  ++KT L  L+DE+ + E+    
Sbjct: 1505 EMEDLMSSKD-------DVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLR 1557

Query: 241  LQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMES 300
            L+               Q  K Q   ++ + R E    K  Q+     + V +M  ++E 
Sbjct: 1558 LE------------VNLQAMKAQFERDL-QGRDEQSEEKKKQLV----RQVREMEAELED 1600

Query: 301  HLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLE 360
              K+      +    E  L + +  +        +    +R+LQ Q+      L      
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660

Query: 361  EENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLE 420
             E  L Q K EN ++KL+ M+AE  +L+++LA  E   + +  +  E + E    + +  
Sbjct: 1661 REEILAQAK-EN-EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718

Query: 421  AALEEGRQ---KVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQE 477
             ALEE R+   ++A+  E++   +   ++    +   L+K N + +Q+   +N +  H +
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTEL----INDRLKKANLQIDQINTDLNLERSHAQ 1774

Query: 478  VCLKEVQNSLEKSENQNESIKNYLQ 502
                + +N+ ++ E QN+ +K  LQ
Sbjct: 1775 ----KNENARQQLERQNKELKVKLQ 1795



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 120/530 (22%), Positives = 230/530 (43%), Gaps = 72/530 (13%)

Query: 15   NLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKE 74
            +L+ +V E+E   Q L    +  + N  +     +  +   ++LQ++    EA+  KL+E
Sbjct: 919  DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978

Query: 75   YVKSLE---TKIAKWN--LQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAI 129
                LE    K+AK    L+ R+ +    + +E  + K++A  K                
Sbjct: 979  EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK---------------- 1022

Query: 130  EKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKME 189
             K  + I D E +L          +    K+  + T+L  QI  ++ QI  L   L K E
Sbjct: 1023 NKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE 1082

Query: 190  DHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQK 249
                   EE+   +  +E E    N+   K++   + + +    +E+E +   + EK+++
Sbjct: 1083 -------EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135

Query: 250  TL---IEMYKTQVQKLQE---AAEIVKSRCE---NLLHKN-NQITKTKNKNVEKMRGQME 299
             L   +E  KT+++   +   A + ++S+ E   N+L K   +  KT    +++MR +  
Sbjct: 1136 DLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 300  SHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSL 359
              ++EL    +     +  L + +++L+  +G+ A++   +  LQG+ D  H    +  +
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL--LQGKGDSEHK---RKKV 1250

Query: 360  EEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQL 419
            E +   +Q+K    ++   ++  +  +L+ +L N    L  S+ K  + + +++AL  QL
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL 1310

Query: 420  ----EAALEEGRQKVA-------EEIEKMSSRESALQIKILDLETELRKKNEEQ----NQ 464
                E   EE RQK++        E EK S RE       L+ E E +   E+Q    + 
Sbjct: 1311 QDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ------LEEEEEAKHNLEKQIATLHA 1364

Query: 465  LVCKMNSKAQHQEVCL---KEVQNSLEK-----SENQNESIKNYLQFLKT 506
             V  M  K +    CL   +EV+  L+K     S+   E +  Y +  KT
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 91/516 (17%), Positives = 230/516 (44%), Gaps = 45/516 (8%)

Query: 3    LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
            L  + +  ++     KK+ E E+ I EL    +SE+A+  KA +  + +    E L+ ++
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148

Query: 63   HKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMK---EASRQKTVALKKASKVYK 119
                           +L++  A+  L+S+  +   I+ K   E ++     +++  + + 
Sbjct: 1149 E-------------DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 120  QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQII 179
            Q ++     +E+ T +++    K  +T+       ++  K++++    +   E  +K++ 
Sbjct: 1196 QAVEELAEQLEQ-TKRVKANLEKAKQTLENERGELANEVKVLLQG---KGDSEHKRKKVE 1251

Query: 180  NLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELS 239
              L++L+   + G+    E+  KV  ++ E + +    ++  +  + L  +  ++E++L 
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQ 1311

Query: 240  ELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQME 299
            + QE+ +++        T+++++++     K+     L +  +      K +  +  Q+ 
Sbjct: 1312 DTQELLQEENRQKLSLSTKLKQVEDE----KNSFREQLEEEEEAKHNLEKQIATLHAQVA 1367

Query: 300  SHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQ-------EHTIRELQGQVDGNHN 352
               K++E     L  AE    + Q+ L+    +  ++       E T   LQ ++D   +
Sbjct: 1368 DMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELD---D 1424

Query: 353  LLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEY 412
            LL  L  + ++       E  Q+K +Q+ AE K +  K A + +    +  + +EK  + 
Sbjct: 1425 LLVDLDHQRQSA---CNLEKKQKKFDQLLAEEKTISAKYAEERD---RAEAEAREKETKA 1478

Query: 413  TALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSK 472
             +LAR LE A+E+       E+E+++ +       ++  + ++ K   E  +    +  +
Sbjct: 1479 LSLARALEEAMEQ-----KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533

Query: 473  AQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
             +  +  L+E+++ L+ +E+    ++  LQ +K  +
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF 1569



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 110/505 (21%), Positives = 211/505 (41%), Gaps = 87/505 (17%)

Query: 26   HIQELSCLFQSE--KANTLKANRFSQSVKVVHERLQIQIHKREAENDKLK-----EYVKS 78
            H ++ +C  + +  K + L A   + S K   ER + +   RE E   L      E    
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490

Query: 79   LETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRD 138
             + ++ + N Q R    + +  K+   +    L+K+ +  +Q+       +E++ +Q+ +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ-------VEEMKTQLEE 1543

Query: 139  QEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEE 198
             E +L  T  A              K  LEV ++ MK Q      DL+  ++  +   ++
Sbjct: 1544 LEDELQATEDA--------------KLRLEVNLQAMKAQFER---DLQGRDEQSEEKKKQ 1586

Query: 199  ILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLIEMYKT 257
            ++R+V  +E E E    E  +    +AA K     +E +L +L+  ++   K   E  K 
Sbjct: 1587 LVRQVREMEAELED---ERKQRSMAVAARK----KLEMDLKDLEAHIDSANKNRDEAIK- 1638

Query: 258  QVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAER 317
            Q++KLQ   +      ++      +I     +N +K++  ME+ + +L+   + L AAER
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS-MEAEMIQLQ---EELAAAER 1694

Query: 318  RLHECQ---------------------ESLQCCKGKCADQEHTIRELQGQVDGNHNLLTK 356
               + Q                     E  +  + + A  E  + E QG  +  ++ L K
Sbjct: 1695 AKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKK 1754

Query: 357  LSLEEENCLIQL--------KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEK 408
             +L+ +     L        K EN +Q+LE+   +NKEL+ KL   E  +K    K+K  
Sbjct: 1755 ANLQIDQINTDLNLERSHAQKNENARQQLER---QNKELKVKLQEMEGTVKS---KYKAS 1808

Query: 409  SAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCK 468
                 A   QLE  L+   ++     +++   E  L+  +L ++ E R   + ++Q    
Sbjct: 1809 ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQ---- 1864

Query: 469  MNSKAQHQEVCLKEVQNSLEKSENQ 493
                A      LK+++  LE++E +
Sbjct: 1865 ----ADKASTRLKQLKRQLEEAEEE 1885



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 94/441 (21%), Positives = 198/441 (44%), Gaps = 43/441 (9%)

Query: 82   KIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA-----IEKLTSQI 136
            K+  W       K + ++  + SRQ+   + K  ++ K R            +E L SQ+
Sbjct: 821  KLRNWQWWRLFTKVKPLL--QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQL 878

Query: 137  RDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSC 196
              ++ +L E + A         ++  E  EL  ++   K+++  +  DL+   +  +  C
Sbjct: 879  MAEKLQLQEQLQAET-------ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERC 931

Query: 197  EEILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYK 256
            + +  +   ++   + L  +  + ++    L+ E V+ E +L +L+E    ++ ++E   
Sbjct: 932  QHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE----EQIILE--- 984

Query: 257  TQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAE 316
             Q  KL +  ++++ R       N    + K+K++ K++ + E+ + +LE   + L   E
Sbjct: 985  DQNCKLAKEKKLLEDRIAEFT-TNLTEEEEKSKSLAKLKNKHEAMITDLE---ERLRREE 1040

Query: 317  RRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQ-- 374
            ++  E +++ +  +G   D    I ELQ Q+      L K   E +  L +++ E  Q  
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100

Query: 375  ---QKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVA 431
               +K+ +++++  EL++ L ++      +  + ++   E  AL  +LE  L+      A
Sbjct: 1101 MALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD----STA 1156

Query: 432  EEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKA----QHQEVCLKEVQNSL 487
             + E  S RE  + I    LE E  K +E Q Q + + +S+A      Q    K V+ +L
Sbjct: 1157 AQQELRSKREQEVNILKKTLEEE-AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215

Query: 488  EKS----ENQNESIKNYLQFL 504
            EK+    EN+   + N ++ L
Sbjct: 1216 EKAKQTLENERGELANEVKVL 1236



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 114/570 (20%), Positives = 234/570 (41%), Gaps = 104/570 (18%)

Query: 4    ENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH 63
            + L     +  N+ KK  E+EA   E       +K         SQ+V+ + E+L+ Q  
Sbjct: 1159 QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK--------HSQAVEELAEQLE-QTK 1209

Query: 64   KREAENDKLKEYVKSLETKIA---------KWNLQSRMNKNEA------IVMKEASRQKT 108
            + +A  +K K+ +++   ++A         K + + +  K EA      +   E  R +T
Sbjct: 1210 RVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRT 1269

Query: 109  VALKKASKVYKQRLDHFTGAIEK--------------LTSQIRDQE-------------- 140
                K +K+  + LD+ TG + +              L SQ++D +              
Sbjct: 1270 ELADKVTKLQVE-LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLS 1328

Query: 141  AKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGK--NSCEE 198
             KL +     N+++   E+    K  LE QI T+  Q+ ++    KKMED      + EE
Sbjct: 1329 TKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK---KKMEDSVGCLETAEE 1385

Query: 199  ILRKVHS----IEYENETLNLENTKLKTTLAALKDEV----VSVENELSELQEVEKKQKT 250
            + RK+      +   +E       KL+ T   L+ E+    V ++++      +EKKQK 
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 251  ---LIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLK---- 303
               L+   KT   K  E  +  ++       K   + +   + +E+ + ++E   K    
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQ-KAELERLNKQFRT 1504

Query: 304  ELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEEN 363
            E+E +  S     + +HE ++S +  + +  + +  + EL+ ++    +   KL LE   
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED--AKLRLEVN- 1561

Query: 364  CLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAAL 423
              +Q      ++ L+  D +++E +K+L  Q                      R++EA L
Sbjct: 1562 --LQAMKAQFERDLQGRDEQSEEKKKQLVRQ---------------------VREMEAEL 1598

Query: 424  EEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEV 483
            E+ R++ +  +    +    L++ + DLE  +   N+ +++ + ++       + C++E+
Sbjct: 1599 EDERKQRSMAV----AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654

Query: 484  QNSLEKSENQNESIKNYLQFLKTSYVTMFE 513
             ++    E      K   + LK+    M +
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQ 1684


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 118/543 (21%), Positives = 228/543 (41%), Gaps = 80/543 (14%)

Query: 3   LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQI 62
           LE LT+  +E    +      E  +QEL    ++E+       R    + ++  +LQ  +
Sbjct: 200 LEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERE---LVERRQDQLGLMSLQLQEAL 256

Query: 63  HKREAENDKLKEYVKSL--ETKIAKWNLQSRMNKNEAIV-MKEASRQKTVALKKASKVYK 119
            K+EA+ D+ +  +K+   +T+  K  L+  +  +  ++   E SR+  +   +  +   
Sbjct: 257 KKQEAKADEHEGAIKNKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVEELRTQL 316

Query: 120 QRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQI- 178
            + +     ++   SQI  Q++   +       ++   E+   EK +LE Q+  ++ Q+ 
Sbjct: 317 TKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVER---EKQDLEKQMSDLRVQLN 373

Query: 179 -------------------------INLLEDLKKMEDHGKNSCEEILRKVHSIEYENETL 213
                                     + +E+L +  ++G+    ++L ++  I+   +T 
Sbjct: 374 FSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTC 433

Query: 214 NLENTKLKTTLAAL----KDEVVSVENELSELQ-------EVEKKQKTL-------IEMY 255
             E       ++ L    +D     E  LSELQ       E EK+++ L       I  +
Sbjct: 434 EAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQW 493

Query: 256 KTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRG---QMESHLKELERVCDSL 312
           K + +KL+ A E      + L  KNNQI K K++   ++     Q+E+  KEL  V    
Sbjct: 494 KLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKR 553

Query: 313 TAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCEN 372
              E  LH  +E L+  K   AD E    E++  +D  H L ++L  + +   IQ     
Sbjct: 554 ALQEEELHSKEEKLRDIKSHQADLE---LEVKNSLDTIHRLESELKKQSK---IQ----- 602

Query: 373 LQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAE 432
                 QM  E   LE+++A     LK S  + K K  E     + L A   +   K+AE
Sbjct: 603 -----SQMKVEKAHLEEEIAE----LKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAE 653

Query: 433 EIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSEN 492
           E       + A+   + DL  + + ++EE   ++ ++  +    +  LK++ +SL+  + 
Sbjct: 654 E----ERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKT 709

Query: 493 QNE 495
           ++E
Sbjct: 710 KHE 712



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 133/612 (21%), Positives = 264/612 (43%), Gaps = 132/612 (21%)

Query: 5   NLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIH- 63
           N +   SE   +K+ +  K+     L+   Q E       N   Q ++++    +IQ H 
Sbjct: 373 NFSAMASELEEVKRCMERKDKEKAHLAS--QVENLTRELENGEKQQLQMLDRLKEIQNHF 430

Query: 64  -----KREAENDKLKEYVKSLE--TKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASK 116
                +R+  + ++ E  +  E  TK A+  L S + ++EA+  +   R++ + LK    
Sbjct: 431 DTCEAERKHADLQISELTRHAEDATKQAERYL-SELQQSEALKEEAEKRREDLKLKAQES 489

Query: 117 VYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKK 176
           + + +L H     +KL   +  Q   + E    +N       +I+ EK EL+ Q+    +
Sbjct: 490 IRQWKLKH-----KKLERALEKQSETVDELTGKNN-------QILKEKDELKTQLYAALQ 537

Query: 177 QIINLLEDL------KKMEDHGKNSCEEILR--KVHSIEYENETLNLENT--KLKTTL-- 224
           QI NL ++L      + +++   +S EE LR  K H  + E E  N  +T  +L++ L  
Sbjct: 538 QIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKK 597

Query: 225 -----AALKDEVVSVENELSELQEVEKKQKT-LIEMYKTQVQKLQEAAEIVKSRCENLLH 278
                + +K E   +E E++EL++ + + K  L+EM     Q+  +    +++   N L 
Sbjct: 598 QSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEM-----QESIKDLSAIRADLANKLA 652

Query: 279 KNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAA----ERRLHECQESLQCCKGKCA 334
           +  +  K   K++  +  Q +S  +E   +   L       +R L +   SLQ  K K  
Sbjct: 653 EEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTK-- 710

Query: 335 DQEHTIREL-------QGQVDGNHNLLTKLSLEEENCL---------IQLKCENLQQKLE 378
             E  I+EL       + + + +   L   SLEE+N           ++ +C+ L ++L 
Sbjct: 711 -HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELT 769

Query: 379 QMDAENKEL--------------EKKLANQEECLKH---SNLKFK--------EKSAEYT 413
           Q + ENK+L              EK ++ +EE L+    + L+ K        E+ +   
Sbjct: 770 QNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILG 829

Query: 414 ALARQLEAA----------------------------LEEGRQKV---AEEIEKMSSRES 442
            + ++++AA                            L E + K+    EE+++  +RE 
Sbjct: 830 VIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERENREK 889

Query: 443 ALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEV----QNSLEKSENQNE--- 495
            L+ +++    +LR   E +   +  +  + + QE  L E+    ++ LE+++ ++E   
Sbjct: 890 NLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEETQRKDEEMG 949

Query: 496 SIKNYLQFLKTS 507
           S+++ +  L+TS
Sbjct: 950 SLQDRVIALETS 961



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 87/454 (19%), Positives = 191/454 (42%), Gaps = 62/454 (13%)

Query: 61  QIHKREAENDKLKEYVKSLETKIAK-----WNLQSRMNKNEAI-----VMKEASRQKTVA 110
           ++H +E +   +K +   LE ++         L+S + K   I     V K    ++   
Sbjct: 559 ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAE 618

Query: 111 LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ 170
           LKK+    K +L     +I+ L++   D   KL+E   A  A       ++ + ++L  Q
Sbjct: 619 LKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKA-------VLKDLSDLTAQ 671

Query: 171 IETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAALKDE 230
            ++  ++   ++  LK   D  +   +++   + S++ ++E        ++  +   K E
Sbjct: 672 AKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQ------NIQELMKHFKKE 725

Query: 231 VVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKN 290
               EN +  L+    ++K + ++++ Q++KL       KS+C+ L     ++T+ +N+N
Sbjct: 726 KSEAENHIRTLKAESLEEKNMAKIHRGQLEKL-------KSQCDRL---TEELTQNENEN 775

Query: 291 ------VEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQ 344
                  + ++ Q+E   K +    + L   E    + ++ L C +    +QE  +  + 
Sbjct: 776 KKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLE---TEQESILGVIG 832

Query: 345 GQVDGNHNLLTKLSLEEENCLIQLK---------CENLQQKLEQMDAENKELEKKLANQE 395
            ++D      +K S+E+                     + KL+ +  E KE E    N+E
Sbjct: 833 KEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELKERE----NRE 888

Query: 396 ECLKHSNLKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETEL 455
           + L+H  +  +++        R L    E   Q + ++IE+       +  +  DL  E 
Sbjct: 889 KNLRHQLMLCRQQ-------LRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLLEET 941

Query: 456 RKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK 489
           ++K+EE   L  ++ +     +V L  +++  EK
Sbjct: 942 QRKDEEMGSLQDRVIALETSTQVALDHLESVPEK 975



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 86/424 (20%), Positives = 177/424 (41%), Gaps = 60/424 (14%)

Query: 3   LENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHE-----R 57
           +ENL   E  +   K+ + E+E H +E       EK   +K+++    ++V +      R
Sbjct: 539 IENLR-KELNDVLTKRALQEEELHSKE-------EKLRDIKSHQADLELEVKNSLDTIHR 590

Query: 58  LQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEA-------------- 103
           L+ ++ K+     ++K     LE +IA+       +K + + M+E+              
Sbjct: 591 LESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANK 650

Query: 104 ----SRQKTVALKKASKVY---KQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSH 156
                R K   LK  S +    K R +     I +L  +    + +L +  S+  + K+ 
Sbjct: 651 LAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTK 710

Query: 157 YEKIVIE--------KTELEVQIETMKKQII---NLLEDLKKMEDHGKNSCEEILRKVHS 205
           +E+ + E        K+E E  I T+K + +   N+ +  +   +  K+ C+ +  ++  
Sbjct: 711 HEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQ 770

Query: 206 IEYENETLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKL--- 262
            E EN+ L L+   LK  L   +  +   E  L  ++E   + K  +   +T+ + +   
Sbjct: 771 NENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGV 830

Query: 263 --QEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLH 320
             +E     K+  ++ + K    +   + + +  R   ES  K L+ +C+ L   E R  
Sbjct: 831 IGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTK-LQWLCEELKERENREK 889

Query: 321 ECQESLQCCKGK----CADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK 376
             +  L  C+ +      ++E  ++ L  Q++    LL ++  E+ + L     E  Q+K
Sbjct: 890 NLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIHREKRDLL-----EETQRK 944

Query: 377 LEQM 380
            E+M
Sbjct: 945 DEEM 948


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 111/511 (21%), Positives = 220/511 (43%), Gaps = 73/511 (14%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANR----FSQSVKVVHER 57
            L+  + D ++    L+KK+ E +A I+EL    ++E+A+  KA +     S+ ++ + ER
Sbjct: 1093 LISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISER 1152

Query: 58   L---------QIQIH-KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQK 107
            L         Q++++ KREAE  KL+  ++  E  +    + + + K  A  M E   Q 
Sbjct: 1153 LEEAGGATSAQVELNKKREAEFQKLRRDLE--EATLQHEAMVAALRKKHADSMAELGEQ- 1209

Query: 108  TVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTEL 167
               +    +V KQ+L       EK  S+++ +   LS    A +  K + EK+     + 
Sbjct: 1210 ---IDNLQRV-KQKL-------EKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQ 1258

Query: 168  EVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTLAAL 227
              +++T +++   L+ DL       +    E  R++   +     L+         +  L
Sbjct: 1259 VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEEL 1318

Query: 228  KDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTK 287
            K ++       + L    +  +   ++ + Q ++ QE     K+  +  L K        
Sbjct: 1319 KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEG----KAELQRALSK-------A 1367

Query: 288  NKNVEKMRGQMESH-LKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQ 346
            N  V + R + E+  ++  E + ++     +RL E +E ++    KCA  E T + LQ +
Sbjct: 1368 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNE 1427

Query: 347  VDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFK 406
            V                       E+L   +E+ +A    L+KK  N ++ L     K++
Sbjct: 1428 V-----------------------EDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464

Query: 407  EKSAEYTAL---ARQLEAALEEGR---QKVAEEIEKMSSRESALQIKILDLETELRKKNE 460
            E  AE  A    +R L   L + +   ++  +++E +      LQ +I DL  ++ +  +
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGK 1524

Query: 461  EQNQLVCKMNSKAQHQEVCLKEVQNSLEKSE 491
            + ++L  +   K   QE C  E+Q +LE++E
Sbjct: 1525 QIHEL--EKIKKQVEQEKC--EIQAALEEAE 1551



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 123/575 (21%), Positives = 241/575 (41%), Gaps = 103/575 (17%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKREAEN 69
            ++E     +++ EK+A + +LS   +S++A+T +       ++   +      H  ++  
Sbjct: 1284 QTEAGEYSRQLDEKDALVSQLS---RSKQASTQQIEELKHQLEEETKAKNALAHALQSSR 1340

Query: 70   ---DKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASR------QKTVALKKASKVYKQ 120
               D L+E  +  E +  K  LQ  ++K  + V +  ++      Q+T  L++A K   Q
Sbjct: 1341 HDCDLLREQYE--EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1398

Query: 121  RLDHFT----------GAIEKLTSQIRDQEAKLSETISASNA------------------ 152
            RL               ++EK   +++++   L   +  SNA                  
Sbjct: 1399 RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSE 1458

Query: 153  WKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYENET 212
            WK  YE       E + ++E  +K+  +L  +L K+    KN  EE L ++ ++  EN+ 
Sbjct: 1459 WKQKYE-------ETQAELEASQKESRSLSTELFKV----KNVYEESLDQLETLRRENKN 1507

Query: 213  LNLENTKLKTTLAA-------LKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEA 265
            L  E + L   +A        L+     VE E  E+Q   ++ +  +E  + ++ ++Q  
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567

Query: 266  AEIVKSRCEN-LLHKNNQITKTKNKN---VEKMRGQMESHLKELERVCDSLTAAERRLHE 321
               VKS  +  +  K+ +I + K  +   VE M+  +++ ++            E  L+E
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNE 1627

Query: 322  CQESLQCCKGKCADQEHTIRELQG-----------QVDGNHNLLTKLSLEEENC-LIQLK 369
             +  L       A+     R  QG            + G  +L  +L++ E    L+Q +
Sbjct: 1628 MEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1687

Query: 370  CENLQQKLEQMDAENKELEKKL--ANQEECLKHS------NLKFKEKSAEYTALARQLEA 421
             E L   LEQ +   K  E++L  A++   L H+      N K K+   + + L  ++E 
Sbjct: 1688 IEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTK-KKLENDVSQLQSEVEE 1746

Query: 422  ALEEGRQ-------------KVAEEIEKMSSRESALQIKILDLE---TELRKKNEEQNQL 465
             ++E R               +AEE++K     + L+    +LE    +L+ + +E  QL
Sbjct: 1747 VIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1806

Query: 466  VCKMNSK-AQHQEVCLKEVQNSLEKSENQN-ESIK 498
              K   K  Q  E  ++E++  +E  + +N E++K
Sbjct: 1807 ALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 90/444 (20%), Positives = 191/444 (43%), Gaps = 33/444 (7%)

Query: 74   EYVKSLETKIA----KWNLQSRMNKNE----AIVMKEASRQKTVALKKASKVYKQRLDHF 125
            EY K L+ + A    ++N+++ MN        +  K     K+   +K     K+     
Sbjct: 803  EYQKMLQRREALFCIQYNVRAFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKT 862

Query: 126  TGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDL 185
               + K  ++ ++ E K+   +   N  +   +       + E + E + K  I L   +
Sbjct: 863  KDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKI 922

Query: 186  KKMEDHGKNSCE---EILRKVHSIEYENETLNLENTKLKTTLAALKDEVVSVENELSELQ 242
            K++ +  +   E   E+  K   +E E   L  +   L+ TLA ++ E  + EN++  L 
Sbjct: 923  KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 982

Query: 243  EVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVEKMRGQMESHL 302
            E        I     + + LQE  +      +    K N +TK K K +E+    +E  L
Sbjct: 983  EEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK-LEQQVDDLEGSL 1041

Query: 303  KELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNH----NLLTKLS 358
            ++ +++   L  A+R+L   +  L+  +    D E+  ++L  +++       NL++K+ 
Sbjct: 1042 EQEKKLRMDLERAKRKL---EGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIE 1098

Query: 359  LEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQ 418
             +E+   IQ     LQ+K++++ A  +EL +++    E  + S  K +++ ++ +    +
Sbjct: 1099 -DEQAVEIQ-----LQKKIKELQARIEELGEEI----EAERASRAKAEKQRSDLSRELEE 1148

Query: 419  LEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEV 478
            +   LEE     + ++E    RE+  Q     L  +L +   +   +V  +  K      
Sbjct: 1149 ISERLEEAGGATSAQVELNKKREAEFQ----KLRRDLEEATLQHEAMVAALRKKHADSMA 1204

Query: 479  CLKEVQNSLEKSENQNESIKNYLQ 502
             L E  ++L++ + + E  K+ L+
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELK 1228



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 67/366 (18%), Positives = 155/366 (42%), Gaps = 39/366 (10%)

Query: 35   QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKLKEYVKSLETKIAKWNLQS---- 90
            + E+ + LK N  ++ V+ +   L  +I  R   ND L+   K +E  + +  +Q     
Sbjct: 1582 KDEEIDQLKRNH-TRVVETMQSTLDAEIRSR---NDALR-VKKKMEGDLNEMEIQLNHAN 1636

Query: 91   -------RMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKL 143
                   R  +N   ++KE       AL+    + +Q        +E+  + ++ +  +L
Sbjct: 1637 RLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ-----LAIVERRANLLQAEIEEL 1691

Query: 144  SETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKV 203
              T+  +   +   E+ +++ +E    + T    +IN  + L+      ++  EE++++ 
Sbjct: 1692 WATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQES 1751

Query: 204  HSIEYENE-------TLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLIEMY 255
             + E + +        +  E  K + T A L+    ++E  + +LQ  +++ ++  ++  
Sbjct: 1752 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1811

Query: 256  KTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKN---VEKMRGQMESHLKELERVCD-- 310
            K Q+QKL+     ++   EN   +N +  K   K+   V+++  Q E   K + R+ D  
Sbjct: 1812 KKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLV 1871

Query: 311  -----SLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCL 365
                  + + +R+  E +E       K    +H + E + + D   + + KL ++     
Sbjct: 1872 DKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVH 1931

Query: 366  IQLKCE 371
             ++  E
Sbjct: 1932 TKISAE 1937



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 12/194 (6%)

Query: 10   ESENTNLK-KKVFEKEAHIQELSCLFQSEKANTLKANR-FSQSVKVVHERL----QIQIH 63
            ES N   K KK     A + E     Q   A+  +  +   Q+VK +  RL    Q+ + 
Sbjct: 1750 ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1809

Query: 64   KREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLD 123
              + +  KL+  V+ LE ++   N Q R    EA+       ++   L   ++  ++ + 
Sbjct: 1810 GGKKQIQKLEARVRELEGEVE--NEQKR--NAEAVKGLRKHERRVKELTYQTEEDRKNVL 1865

Query: 124  HFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLE 183
                 ++KL ++++  + +  E    SNA  S + K+  E  E E + +  + Q+  L  
Sbjct: 1866 RLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKL-- 1923

Query: 184  DLKKMEDHGKNSCE 197
             +K  E H K S E
Sbjct: 1924 RVKSREVHTKISAE 1937


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 104/545 (19%), Positives = 226/545 (41%), Gaps = 64/545 (11%)

Query: 6    LTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQIHKR 65
            L + E +     K     E+ +Q+   L Q E    L  +   + ++     LQ Q  + 
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355

Query: 66   EAENDKLKEYVKSLETKIAKW------------NLQSRMNK--NEAIVMKEASRQKTVAL 111
            E     L++ V +L++++A              +L+    K   +A  + +   +K +A 
Sbjct: 1356 EEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 112  KKASKV---YKQRLDHFTGAIE---KLTSQIRDQEAKLSETISASNAWKSHY----EKIV 161
             K  K     +Q LD  T  ++   ++ S +  ++ K  + ++   +  + Y    ++  
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 162  IEKTELEVQIETMKKQIINLLEDLKKMEDHGK----------NSCEEILRKVHSIEYENE 211
             E  E E +  ++ + +   LE  ++ E   K          +S +++ + VH +E    
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535

Query: 212  TLNLENTKLKTTLAALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKS 271
             L  +  +++T L  L+DE+ + E+    L+   +  K   E      + LQ   E    
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE------RDLQTRDE---- 1585

Query: 272  RCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKG 331
                   +N +  +   K V ++  ++E   K+      S    E  L + +  ++    
Sbjct: 1586 -------QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638

Query: 332  KCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKL 391
               +    +R+LQ Q+      L +     +    Q K    ++KL+ ++AE  +L+++L
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK--ESEKKLKSLEAEILQLQEEL 1696

Query: 392  ANQEECLKHSNLKFKEKSAEYTALARQLEAALEEGRQ---KVAEEIEKMSSRESALQIKI 448
            A+ E   +H+  +  E + E T  A    A L+E R+   ++A+  E++   +S +++  
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMEL-- 1754

Query: 449  LDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
              L    RK   +    V  +N++   +    ++  N+ ++ E QN+ +K  LQ L+ + 
Sbjct: 1755 --LNDRFRKTTLQ----VDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808

Query: 509  VTMFE 513
             + F+
Sbjct: 1809 KSKFK 1813



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 104/526 (19%), Positives = 234/526 (44%), Gaps = 52/526 (9%)

Query: 3    LENLTDNESE-NTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            LE+  + E E N  L+ +  + +AHIQ+L      E+                 ++LQ++
Sbjct: 927  LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG--------------ARQKLQLE 972

Query: 62   IHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQR 121
                EA+  K++E +  LE + +K+  + ++ ++    + E S Q     +KA  + K R
Sbjct: 973  KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR---IAECSSQLAEEEEKAKNLAKIR 1029

Query: 122  LDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINL 181
             +     I  L  +++ +E    E   A          +  +  EL+ QI+ +K Q+   
Sbjct: 1030 -NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088

Query: 182  LEDLKKMEDHG------KNSCEEILRKVHS----IEYENETLNLENTKLKTTLAALKDEV 231
             E+L+     G      KN+  +++R++ +    ++ + E+      K +     L +E+
Sbjct: 1089 EEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEEL 1148

Query: 232  VSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNV 291
             +++ EL +  +    Q+ L      + ++ QE AE+ K+  E   +   QI   + ++ 
Sbjct: 1149 EALKTELEDTLDTTAAQQEL------RTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202

Query: 292  EKMRGQMESHLKELERVCDSLTAAERRLHECQESLQC----CKGKCADQEHTIRELQGQV 347
              +  ++   L++ +R   +L   ++ L    + L C     +   A+ EH  ++L  QV
Sbjct: 1203 TALE-ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261

Query: 348  DGNHNLLT-----KLSLEEENCLIQLKCENLQQKLEQMDAENKELEKKLANQEECLKHSN 402
               H  ++     ++ L E+   +Q + +N+   LE+ + +  +  K  A+ E  L+ + 
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321

Query: 403  LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 462
               +E++ +   L+ ++   LEE +  + E+ E+       L+ ++L L+++L    ++ 
Sbjct: 1322 ELLQEETRQKLNLSSRIR-QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380

Query: 463  NQLVCKMNSKAQHQEVCLKEVQNSLEKSE------NQNESIKNYLQ 502
            +  +  + S  + ++  LK+ +   ++ E      ++ E  KN LQ
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 107/491 (21%), Positives = 213/491 (43%), Gaps = 79/491 (16%)

Query: 35   QSEKANTLKANRFSQSVKVVHERLQIQIHKREAENDKL---KEYVKSLETK--IAKWNLQ 89
            + +K + L A   S S +   ER + +   RE E   L   +   ++LE K    + N Q
Sbjct: 1449 KQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQ 1508

Query: 90   SRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISA 149
             R +  + +  K+   +    L+K+ +  +Q+       +E++ +Q+ + E +L  T  A
Sbjct: 1509 LRADMEDLMSSKDDVGKNVHELEKSKRALEQQ-------VEEMRTQLEELEDELQATEDA 1561

Query: 150  SNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKMEDHGKNSCEEILRKVHSIEYE 209
                          K  LEV ++ MK Q      DL+  ++  +     ++++V  +E E
Sbjct: 1562 --------------KLRLEVNMQAMKAQFER---DLQTRDEQNEEKKRLLIKQVRELEAE 1604

Query: 210  NETLNLENTKLKTTLAALKDEVVSVENELSELQ-EVEKKQKTLIEMYKTQVQKLQEAAEI 268
                 LE+ + +  LA    +   +E +L +L+ ++E   K   E+ K Q++KLQ   + 
Sbjct: 1605 -----LEDERKQRALAVASKK--KMEIDLKDLEAQIEAANKARDEVIK-QLRKLQAQMKD 1656

Query: 269  VKSRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESL-- 326
             +   E      ++I   ++K  EK    +E+ + +L+    S   A R   + ++ L  
Sbjct: 1657 YQRELEEARASRDEIF-AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715

Query: 327  ----------------QCCKGKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQL-- 368
                            +  + + A  E  + E Q  ++  ++   K +L+ +    +L  
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA 1775

Query: 369  ------KCENLQQKLEQMDAENKELEKKLANQEECLKHSNLKFKEKSAEYTALARQLEAA 422
                  K +N +Q+LE+   +NKEL+ KL   E  +K    KFK   +   A   QLE  
Sbjct: 1776 ERSAAQKSDNARQQLER---QNKELKAKLQELEGAVKS---KFKATISALEAKIGQLEEQ 1829

Query: 423  LEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKE 482
            LE+  ++ A   + +   E  L+   + +E E R  ++ + Q+  K N++       +K+
Sbjct: 1830 LEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME-KANAR-------MKQ 1881

Query: 483  VQNSLEKSENQ 493
            ++  LE++E +
Sbjct: 1882 LKRQLEEAEEE 1892



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 73/333 (21%), Positives = 141/333 (42%), Gaps = 65/333 (19%)

Query: 215  LENTKLKTTLAALKDEVVSVENELS----ELQEVEKKQKTLIEMYKTQVQKLQEAAEIVK 270
            L+ T+ +  L A  +E++ V+ + +    EL+E+E+K + L+E      ++LQ   E+  
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF- 903

Query: 271  SRCENLLHKNNQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCK 330
                                 E+MR ++ +  +ELE +   L   E R+ E +E  Q  +
Sbjct: 904  ------------------AEAEEMRARLAAKKQELEEILHDL---ESRVEEEEERNQILQ 942

Query: 331  GKCADQEHTIRELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAENKEL--E 388
             +    +  I++L+ Q+D       KL LE+     + K + +++++  ++ +N +   E
Sbjct: 943  NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTA--EAKIKKMEEEILLLEDQNSKFIKE 1000

Query: 389  KKLANQEECLKHSNLKFKEKSAEYTALARQLEAA------------------LEEGRQKV 430
            KKL         S L  +E+ A+  A  R  +                    LE+ ++K+
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060

Query: 431  AEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVCKMNSKAQHQEVCLKEVQN----- 485
              E   +  + + LQ +I +L+ +L KK EE    + + + +  H+   LK V+      
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120

Query: 486  ------------SLEKSENQNESIKNYLQFLKT 506
                        S  K+E Q   +   L+ LKT
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKT 1153



 Score = 35.8 bits (81), Expect = 0.096
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 21/200 (10%)

Query: 57   RLQIQIHKREAENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVA---LKK 113
            RL+ +I + E E ++ +  ++ L  +  K  LQ      E    + A+++   A   L++
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER 1792

Query: 114  ASKVYKQRLDHFTGAIE-KLTSQIRDQEAK---LSETISASNAWKSHYEKIVIEKTELEV 169
             +K  K +L    GA++ K  + I   EAK   L E +      ++   K+V  +TE ++
Sbjct: 1793 QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV-RRTEKKL 1851

Query: 170  QIETMKKQIINLLEDLKKMEDHGKNSCE-------EILRKVHSIEYENETLNLENTKLKT 222
                  K+I   +ED ++  D  K   E       ++ R++   E E    N    KL+ 
Sbjct: 1852 ------KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905

Query: 223  TLAALKDEVVSVENELSELQ 242
             L    +    +  E+S L+
Sbjct: 1906 ELDDATEANEGLSREVSTLK 1925



 Score = 33.1 bits (74), Expect = 0.62
 Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 38/224 (16%)

Query: 3    LENLTDNESENTNLKKKVFEKEA-HIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            LE   + E  N  L    F K    +  L+    +E++   K++   Q ++  ++ L+ +
Sbjct: 1741 LEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK 1800

Query: 62   IHKRE-AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQ 120
            + + E A   K K  + +LE KI +   Q          +++ ++++  A K   +  K+
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQ----------LEQEAKERAAANKLVRRTEKK 1850

Query: 121  RLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN 180
                    ++++  Q+ D+              + H ++   +  +   +++ +K+Q   
Sbjct: 1851 --------LKEIFMQVEDE--------------RRHADQYKEQMEKANARMKQLKRQ--- 1885

Query: 181  LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTL 224
             LE+ ++       S  ++ R++      NE L+ E + LK  L
Sbjct: 1886 -LEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 114/521 (21%), Positives = 220/521 (42%), Gaps = 77/521 (14%)

Query: 16   LKKKVFEKEAHIQELSCLFQSEKANT----LKANRFSQSVKVVHERLQ---IQIHKREAE 68
            LKKK     A +Q+     + ++        K  RF   +   HE  Q   +Q  K + E
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487

Query: 69   NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 128
             D L     SL+ ++ + ++                 QK V+L+   +    +      +
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIA-----------GFTQKVVSLEAELQDISSQESKDEAS 1536

Query: 129  IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 188
            + K+  Q+RD EAK+ +     +      + +   K  LE+++E M++     +E   + 
Sbjct: 1537 LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEE 1596

Query: 189  EDHGKNSCEEILRKVH---SIEYENETLNL-ENTKLKTTLAALKDEVVSVENELSELQEV 244
             +  + SC++ L+++      EYE++   L E  +L+  LA L D+V          ++ 
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQV--------NRRDF 1648

Query: 245  EKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE---------KMR 295
            E +++   ++ +T+   L   A+++    +N      +I + KN+  E         K R
Sbjct: 1649 ESEKRLRKDLKRTKA--LLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706

Query: 296  GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 355
              ME  +++L    D +  A+  L E    LQ  K           E+Q +++ +   + 
Sbjct: 1707 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN----------EIQNRLEEDQEDMN 1756

Query: 356  KLSLEEENCLIQL-----KCENLQQKLEQMDAENKELEKK---LANQEECLKHSNLKFKE 407
            +L  + +  + Q      +  +LQ +LE+ + E +EL++K   L +Q E L+ S +  K 
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD-KS 1815

Query: 408  KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVC 467
              +   A  R+LE  LE  R +V + +E ++SR          L+  + K  EE++Q + 
Sbjct: 1816 LVSRQEAKIRELETRLEFERTQV-KRLESLASR----------LKENMEKLTEERDQRIA 1864

Query: 468  ------KMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 502
                  + N + Q Q    KE    L + E +    K+ L+
Sbjct: 1865 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELE 1905



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 101/524 (19%), Positives = 216/524 (41%), Gaps = 52/524 (9%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            L   L   E E   L+      E+ I EL+     E+     A++   +      R + +
Sbjct: 1266 LRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKE 1325

Query: 62   IHKREAENDKLKEYVKSLETKIAKWNL------QSRMNKNEA-----IVMKEASRQKTVA 110
            + + + + D LK+ ++ +E ++ +  L         ++ ++A     +  + A R+    
Sbjct: 1326 MKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFT 1385

Query: 111  LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ 170
             K+  + ++ +L+       +L  ++ D +A   E+  A    K   +++  E  + ++ 
Sbjct: 1386 KKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLH 1445

Query: 171  IETMKKQIINLLEDLKKMEDHGKNSCEEILRKV---HSIEYENETLNLENTKLKTTL--- 224
            +E  + +   L +  ++ +     + EE  R+      ++ E + L  E   LK  L   
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEK 1505

Query: 225  ----AALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKN 280
                A    +VVS+E EL ++   E K +  +   K Q++ L+   +  +   +      
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1565

Query: 281  NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTI 340
              + + K +   +M    ++H KE+          E R  E +E+ Q C+ K       +
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEM----------ESRDEEVEEARQSCQKK-------L 1608

Query: 341  RELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAEN-KELEKKLANQEECLK 399
            ++++ Q++  +    K+  E+    ++ K   L  ++ + D E+ K L K L   +  L 
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKRE--LEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA 1666

Query: 400  HSNLKFK--EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRK 457
             + L     + SA       QL+  LEE     A  ++   + E  ++   L ++   + 
Sbjct: 1667 DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKA 1726

Query: 458  KNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK-SENQNESIKNY 500
            K   + QL     S+ Q ++    E+QN LE+  E+ NE +K +
Sbjct: 1727 KTALEEQL-----SRLQREK---NEIQNRLEEDQEDMNELMKKH 1762



 Score = 66.6 bits (161), Expect = 5e-11
 Identities = 113/527 (21%), Positives = 214/527 (40%), Gaps = 64/527 (12%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQ---IQIHKRE 66
            + E    +K   EK+  + E   L Q  +   +    F+Q V  +   LQ    Q  K E
Sbjct: 1475 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1534

Query: 67   AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA----SKVYKQRL 122
            A   K+K+ ++ LE K+     +         ++++A  +  + +++     SK  + R 
Sbjct: 1535 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1594

Query: 123  DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN-- 180
            +    A +    +++  E +L E            +K++ EK ELE ++ T+  Q+    
Sbjct: 1595 EEVEEARQSCQKKLKQMEVQLEEEYEDK-------QKVLREKRELEGKLATLSDQVNRRD 1647

Query: 181  ----------------LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTL 224
                            LL D + M DH KNS      K    + +N+   LE ++     
Sbjct: 1648 FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS---KREIAQLKNQ---LEESEFTCAA 1701

Query: 225  AALKDEVVSVENELSELQEVE-KKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQI 283
            A    + + VE E   LQ  +  K KT +E    Q+ +LQ     +++R E      N++
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALE---EQLSRLQREKNEIQNRLEEDQEDMNEL 1758

Query: 284  TKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIREL 343
             K     V     Q    L ++  +   L  A +   E QE LQ  + +    E      
Sbjct: 1759 MKKHKAAV----AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE------ 1808

Query: 344  QGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK-LEQMDAENKELEKKLANQEECLKHSN 402
            Q  VD   +L+++   +      +L+ E  Q K LE + +  KE  +KL  + +    + 
Sbjct: 1809 QSMVD--KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAE 1866

Query: 403  LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEK-------MSSRESALQIKILDLETEL 455
             + KE++       R  +  + E  +K AE   K       + S E+A Q    DL+   
Sbjct: 1867 NREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAF 1926

Query: 456  RKKNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEKS-ENQNESIKNYL 501
            ++  + Q  +  +M S  +++++   E  + ++   E++ + +K++L
Sbjct: 1927 KRIGDLQAAIEDEMESD-ENEDLINSEGDSDVDSELEDRVDGVKSWL 1972


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 114/521 (21%), Positives = 220/521 (42%), Gaps = 77/521 (14%)

Query: 16   LKKKVFEKEAHIQELSCLFQSEKANT----LKANRFSQSVKVVHERLQ---IQIHKREAE 68
            LKKK     A +Q+     + ++        K  RF   +   HE  Q   +Q  K + E
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487

Query: 69   NDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKASKVYKQRLDHFTGA 128
             D L     SL+ ++ + ++                 QK V+L+   +    +      +
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIA-----------GFTQKVVSLEAELQDISSQESKDEAS 1536

Query: 129  IEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIINLLEDLKKM 188
            + K+  Q+RD EAK+ +     +      + +   K  LE+++E M++     +E   + 
Sbjct: 1537 LAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEE 1596

Query: 189  EDHGKNSCEEILRKVH---SIEYENETLNL-ENTKLKTTLAALKDEVVSVENELSELQEV 244
             +  + SC++ L+++      EYE++   L E  +L+  LA L D+V          ++ 
Sbjct: 1597 VEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQV--------NRRDF 1648

Query: 245  EKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQITKTKNKNVE---------KMR 295
            E +++   ++ +T+   L   A+++    +N      +I + KN+  E         K R
Sbjct: 1649 ESEKRLRKDLKRTKA--LLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706

Query: 296  GQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIRELQGQVDGNHNLLT 355
              ME  +++L    D +  A+  L E    LQ  K           E+Q +++ +   + 
Sbjct: 1707 KAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKN----------EIQNRLEEDQEDMN 1756

Query: 356  KLSLEEENCLIQL-----KCENLQQKLEQMDAENKELEKK---LANQEECLKHSNLKFKE 407
            +L  + +  + Q      +  +LQ +LE+ + E +EL++K   L +Q E L+ S +  K 
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVD-KS 1815

Query: 408  KSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQNQLVC 467
              +   A  R+LE  LE  R +V + +E ++SR          L+  + K  EE++Q + 
Sbjct: 1816 LVSRQEAKIRELETRLEFERTQV-KRLESLASR----------LKENMEKLTEERDQRIA 1864

Query: 468  ------KMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQ 502
                  + N + Q Q    KE    L + E +    K+ L+
Sbjct: 1865 AENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELE 1905



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 101/524 (19%), Positives = 216/524 (41%), Gaps = 52/524 (9%)

Query: 2    LLENLTDNESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQIQ 61
            L   L   E E   L+      E+ I EL+     E+     A++   +      R + +
Sbjct: 1266 LRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKE 1325

Query: 62   IHKREAENDKLKEYVKSLETKIAKWNL------QSRMNKNEA-----IVMKEASRQKTVA 110
            + + + + D LK+ ++ +E ++ +  L         ++ ++A     +  + A R+    
Sbjct: 1326 MKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFT 1385

Query: 111  LKKASKVYKQRLDHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQ 170
             K+  + ++ +L+       +L  ++ D +A   E+  A    K   +++  E  + ++ 
Sbjct: 1386 KKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLH 1445

Query: 171  IETMKKQIINLLEDLKKMEDHGKNSCEEILRKV---HSIEYENETLNLENTKLKTTL--- 224
            +E  + +   L +  ++ +     + EE  R+      ++ E + L  E   LK  L   
Sbjct: 1446 LEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEK 1505

Query: 225  ----AALKDEVVSVENELSELQEVEKKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKN 280
                A    +VVS+E EL ++   E K +  +   K Q++ L+   +  +   +      
Sbjct: 1506 DMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTI 1565

Query: 281  NQITKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTI 340
              + + K +   +M    ++H KE+          E R  E +E+ Q C+ K       +
Sbjct: 1566 QMLEQAKLRLEMEMERMRQTHSKEM----------ESRDEEVEEARQSCQKK-------L 1608

Query: 341  RELQGQVDGNHNLLTKLSLEEENCLIQLKCENLQQKLEQMDAEN-KELEKKLANQEECLK 399
            ++++ Q++  +    K+  E+    ++ K   L  ++ + D E+ K L K L   +  L 
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKRE--LEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA 1666

Query: 400  HSNLKFK--EKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRK 457
             + L     + SA       QL+  LEE     A  ++   + E  ++   L ++   + 
Sbjct: 1667 DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKA 1726

Query: 458  KNEEQNQLVCKMNSKAQHQEVCLKEVQNSLEK-SENQNESIKNY 500
            K   + QL     S+ Q ++    E+QN LE+  E+ NE +K +
Sbjct: 1727 KTALEEQL-----SRLQREK---NEIQNRLEEDQEDMNELMKKH 1762



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 115/526 (21%), Positives = 208/526 (39%), Gaps = 68/526 (12%)

Query: 10   ESENTNLKKKVFEKEAHIQELSCLFQSEKANTLKANRFSQSVKVVHERLQ---IQIHKRE 66
            + E    +K   EK+  + E   L Q  +   +    F+Q V  +   LQ    Q  K E
Sbjct: 1475 QREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDE 1534

Query: 67   AENDKLKEYVKSLETKIAKWNLQSRMNKNEAIVMKEASRQKTVALKKA----SKVYKQRL 122
            A   K+K+ ++ LE K+     +         ++++A  +  + +++     SK  + R 
Sbjct: 1535 ASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRD 1594

Query: 123  DHFTGAIEKLTSQIRDQEAKLSETISASNAWKSHYEKIVIEKTELEVQIETMKKQIIN-- 180
            +    A +    +++  E +L E            +K++ EK ELE ++ T+  Q+    
Sbjct: 1595 EEVEEARQSCQKKLKQMEVQLEEEYEDK-------QKVLREKRELEGKLATLSDQVNRRD 1647

Query: 181  ----------------LLEDLKKMEDHGKNSCEEILRKVHSIEYENETLNLENTKLKTTL 224
                            LL D + M DH KNS      K    + +N+   LE ++     
Sbjct: 1648 FESEKRLRKDLKRTKALLADAQLMLDHLKNSAPS---KREIAQLKNQ---LEESEFTCAA 1701

Query: 225  AALKDEVVSVENELSELQEVE-KKQKTLIEMYKTQVQKLQEAAEIVKSRCENLLHKNNQI 283
            A    + + VE E   LQ  +  K KT +E    Q+ +LQ     +++R E      N++
Sbjct: 1702 AVKARKAMEVEIEDLHLQIDDIAKAKTALE---EQLSRLQREKNEIQNRLEEDQEDMNEL 1758

Query: 284  TKTKNKNVEKMRGQMESHLKELERVCDSLTAAERRLHECQESLQCCKGKCADQEHTIREL 343
             K     V     Q    L ++  +   L  A +   E QE LQ  + +    E      
Sbjct: 1759 MKKHKAAV----AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLE------ 1808

Query: 344  QGQVDGNHNLLTKLSLEEENCLIQLKCENLQQK-LEQMDAENKELEKKLANQEECLKHSN 402
            Q  VD   +L+++   +      +L+ E  Q K LE + +  KE  +KL  + +    + 
Sbjct: 1809 QSMVD--KSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAE 1866

Query: 403  LKFKEKSAEYTALARQLEAALEEGRQKVAEEIEKMSSRESALQIKILDLETELRKKNEEQ 462
             + KE++     L RQL        +   EE+ +++ +E+    K  +LE +L       
Sbjct: 1867 NREKEQNKR---LQRQL--------RDTKEEMGELARKEAEASRKKHELEMDLESLEAAN 1915

Query: 463  NQLVCKMNSKAQHQEVCLKEVQNSLEKSENQNESIKNYLQFLKTSY 508
              L   +    +        +++ +E  E  NE + N LQ + T Y
Sbjct: 1916 QSLQADLKLAFKRIGDLQAAIEDEMESDE--NEDLINSLQDMVTKY 1959


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.123    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,302,984
Number of Sequences: 37866
Number of extensions: 711132
Number of successful extensions: 12439
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 388
Number of HSP's successfully gapped in prelim test: 1033
Number of HSP's that attempted gapping in prelim test: 4647
Number of HSP's gapped (non-prelim): 4182
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.