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Search of human proteins with 55743075
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55743075 angio-associated, migratory cell protein [Homo
sapiens]
(434 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55743075 angio-associated, migratory cell protein [Homo sapiens] 895 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 122 5e-28
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 103 4e-22
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 92 9e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 92 9e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 92 9e-19
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 86 5e-17
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 85 1e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 84 3e-16
gi|16554627 WD repeat domain 5 [Homo sapiens] 84 3e-16
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 83 6e-16
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 83 6e-16
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 82 1e-15
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 79 6e-15
gi|26665869 WD repeat domain 51B [Homo sapiens] 79 1e-14
gi|157266266 WD repeat domain 86 [Homo sapiens] 77 3e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 77 3e-14
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 75 9e-14
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 75 9e-14
gi|16445436 bromodomain and WD repeat domain containing 1 isofor... 75 9e-14
gi|13376840 WD repeat domain 61 [Homo sapiens] 74 2e-13
gi|113865883 WD repeat domain 38 [Homo sapiens] 74 3e-13
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 72 8e-13
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 69 1e-11
gi|21071067 TBP-associated factor 5 [Homo sapiens] 68 1e-11
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 68 1e-11
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 68 1e-11
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 66 7e-11
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 66 7e-11
gi|19913367 transducin beta-like 1Y [Homo sapiens] 66 7e-11
>gi|55743075 angio-associated, migratory cell protein [Homo sapiens]
Length = 434
Score = 895 bits (2313), Expect = 0.0
Identities = 434/434 (100%), Positives = 434/434 (100%)
Query: 1 MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEG 60
MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEG
Sbjct: 1 MESESESGAAADTPPLETLSFHGDEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEG 60
Query: 61 NEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWR 120
NEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWR
Sbjct: 61 NEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWR 120
Query: 121 LSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWM 180
LSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWM
Sbjct: 121 LSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWM 180
Query: 181 EWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIR 240
EWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIR
Sbjct: 181 EWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIR 240
Query: 241 IWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRP 300
IWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRP
Sbjct: 241 IWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRP 300
Query: 301 ETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSG 360
ETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSG
Sbjct: 301 ETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSG 360
Query: 361 IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSG 420
IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSG
Sbjct: 361 IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSG 420
Query: 421 DHKAKVFCVQRPDR 434
DHKAKVFCVQRPDR
Sbjct: 421 DHKAKVFCVQRPDR 434
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 122 bits (307), Expect = 5e-28
Identities = 89/331 (26%), Positives = 151/331 (45%), Gaps = 23/331 (6%)
Query: 102 KTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD-STLVATGDMSGLLKV 160
K+ + +TG D +W + GE L GH++ V F++ +ATG K+
Sbjct: 102 KSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161
Query: 161 WQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGD-CKTFQGPNCP 217
W V+T + +F ++ + ++P++ ++ G+ D +W + NG+ T +G +
Sbjct: 162 WSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE 221
Query: 218 ATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILT 277
G R + G D T+ +WD G +++L G H ++ + N D SLILT
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG---HCAEISSASFNWDCSLILT 278
Query: 278 GSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYL 337
GS+D KL AT GK V G +E + + G L A
Sbjct: 279 GSMDKTCKLWDATNGKCVATLT----------GHDDEILDSCFDYTG-----KLIATASA 323
Query: 338 DGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDY 396
DGT I+ AT+ + + H+ I ++ + + T S D R+WDA+TG+ L
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL 383
Query: 397 RGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
GHT EI A + ++V+T S D+ +++
Sbjct: 384 EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 90.5 bits (223), Expect = 3e-18
Identities = 61/220 (27%), Positives = 98/220 (44%), Gaps = 7/220 (3%)
Query: 86 TFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
TF H+A + C+S +P+ +TL TG D A +W + +GE ++ GH + F+
Sbjct: 172 TFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTS 230
Query: 146 STLVATGDMSGLLKVWQVDT--KEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKV 203
+ TG + VW DT K + ++ ++ ++L G+ D +W
Sbjct: 231 GDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDA 290
Query: 204 PNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGP 262
NG C T G + GK DGT RI+ I L EGH+G
Sbjct: 291 TNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKL---EGHEGE 347
Query: 263 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPET 302
++ ++ N G+ +LTGS D A++ A TG+ + V T
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT 387
Score = 81.3 bits (199), Expect = 2e-15
Identities = 66/216 (30%), Positives = 92/216 (42%), Gaps = 26/216 (12%)
Query: 217 PATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQD-GSLI 275
P T + G + G D T ++WD G ++ L EGH+ + +A N G I
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL---EGHRNVVYAIAFNNPYGDKI 150
Query: 276 LTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVG 335
TGS D KL S TGK FR T + L F L A G
Sbjct: 151 ATGSFDKTCKLWSVETGKCYHTFRGHTA---------------EIVCLSFNPQSTLVATG 195
Query: 336 YLDGTLAIYDLAT----QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGR 391
+D T ++D+ TLR H + I+ L + + T S D V +WDA TGR
Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 392 LLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
+ GH AEI + + D SL++T S D K++
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLW 288
Score = 68.6 bits (166), Expect = 1e-11
Identities = 50/179 (27%), Positives = 80/179 (44%), Gaps = 17/179 (9%)
Query: 251 HVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLG 310
++ K + H PLT VA N+ GS +TGS D KL +G+ +
Sbjct: 83 YLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTL------------ 130
Query: 311 EGEESESNSVESLGFCSVM-PLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEA 368
E N V ++ F + A G D T ++ + T H + H + IV L +
Sbjct: 131 ---EGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 369 GTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
+ +V T S+D +LWD + G + RGH+AEI+ + + ++T S DH V+
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 45.4 bits (106), Expect = 1e-04
Identities = 22/58 (37%), Positives = 34/58 (58%)
Query: 373 VYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
+ T S D +LW TG+ +RGHTAEI+ + + ++LV T S D AK++ +Q
Sbjct: 150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Score = 44.7 bits (104), Expect = 2e-04
Identities = 20/73 (27%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H + +S +P+ N L +TG D A +W G+ L GH D + F++ +V
Sbjct: 344 HEGEISKISFNPQGNHL-LTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIV 402
Query: 150 ATGDMSGLLKVWQ 162
TG ++W+
Sbjct: 403 ITGSKDNTCRIWR 415
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 103 bits (256), Expect = 4e-22
Identities = 99/353 (28%), Positives = 150/353 (42%), Gaps = 33/353 (9%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
HS +V V+ P LA G+ F W LS F C GH+ V +S D +
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRF-WDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEW---MEW-----HPRAPVLLAGTADGNTWMW 201
A+G +G + +W T ++V AG +W + W +P + + + DG+ +W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231
Query: 202 KVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQ 260
G C + G TC R DG +D TI++W G L +GH
Sbjct: 232 DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL---QGHG 287
Query: 261 GPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSV 320
+ +A + D +L TG+ + V+ + S L E S N V
Sbjct: 288 HWVNTMALSTDYAL-RTGAFEPAEASVNP----------QDLQGSLQELKERALSRYNLV 336
Query: 321 ESLGFCSVMPLAAV-GYLDGTLAIYDLA--TQTLRHQCQHQSGIVQLLWEAGTAVVYTCS 377
G P V G D TL ++ A + L HQ+ I Q+L+ + +V + S
Sbjct: 337 RGQG-----PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASAS 391
Query: 378 LDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
D ++LWD RTG+ L RGH A + A S D+ L+V+ S D KV+ V+
Sbjct: 392 FDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Score = 46.6 bits (109), Expect = 4e-05
Identities = 36/143 (25%), Positives = 61/143 (42%), Gaps = 12/143 (8%)
Query: 108 VTGGEDDKAFVWR-LSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTK 166
V+G +D F+W D + L GH+ + FS DS +VA+ +K+W T
Sbjct: 345 VSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTG 404
Query: 167 EEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVL 224
+ + S + + W + +L++G++D +W V + P V
Sbjct: 405 KYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAM----DLPGHADEVY 460
Query: 225 -----PDGKRAVVGYEDGTIRIW 242
PDG+R G +D +RIW
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIW 483
Score = 39.3 bits (90), Expect = 0.007
Identities = 28/115 (24%), Positives = 48/115 (41%), Gaps = 3/115 (2%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H A + V P + +A + D +W G+ L GH +V +S DS L+
Sbjct: 371 HQALINQVLFSPDSRIVA-SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLL 429
Query: 150 ATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWK 202
+G LKVW V ++ A ++ ++W P + +G D +W+
Sbjct: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 4/96 (4%)
Query: 297 VFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ 356
+FR V S EG S +V S+ F A G D T+ +DL+T+T C+
Sbjct: 97 IFRVRAVTRCTSSLEGH---SEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCK 153
Query: 357 -HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGR 391
H+ ++ + W + + +G + LWD TG+
Sbjct: 154 GHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGK 189
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 92.0 bits (227), Expect = 9e-19
Identities = 76/291 (26%), Positives = 122/291 (41%), Gaps = 33/291 (11%)
Query: 108 VTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKE 167
V+G +D+ VW G+ L GH V + + ++ +G LKVW +T E
Sbjct: 277 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGE 334
Query: 168 EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPD 226
+ + H +++G+ D +W + G C G C V D
Sbjct: 335 CIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYD 392
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G+R V G D +++WD + + +H L+G L DG +++GS+D ++
Sbjct: 393 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-----DGIHVVSGSLDTSIRV 447
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
TG + T+ SL G E + N + S G D T+ I+D+
Sbjct: 448 WDVETGNCI-----HTLTGHQSLTSGMELKDNILVS------------GNADSTVKIWDI 490
Query: 347 AT----QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 393
T QTL+ +HQS + L + V T S DG V+LWD +TG +
Sbjct: 491 KTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 539
Score = 85.5 bits (210), Expect = 9e-17
Identities = 78/314 (24%), Positives = 135/314 (42%), Gaps = 34/314 (10%)
Query: 119 WRLSDGELLFECAGHKDSV-TCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDL 177
WR + + GH D V TC F + + +G LKVW T + + +
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 304
Query: 178 EWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYED 236
R ++++G+ D +W G+C T G C + KR V G D
Sbjct: 305 GVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRD 362
Query: 237 GTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVG 296
T+R+WD++ G +HVL G H + CV DG +++G+ D K
Sbjct: 363 ATLRVWDIETGQCLHVLMG---HVAAVRCV--QYDGRRVVSGAYDFMVK----------- 406
Query: 297 VFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ 356
V+ PET +L + +N V SL F + ++ G LD ++ ++D+ T H
Sbjct: 407 VWDPETETCLHTL----QGHTNRVYSLQFDGIHVVS--GSLDTSIRVWDVETGNCIHTLT 460
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRG---HTAEILDFALSKDAS 413
+ + E ++ + + D V++WD +TG+ L +G H + + +K +
Sbjct: 461 GHQSLTSGM-ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--N 517
Query: 414 LVVTTSGDHKAKVF 427
V+T+S D K++
Sbjct: 518 FVITSSDDGTVKLW 531
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/206 (27%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+++V C+ L K V+G D VW + G+ L GH +V C +D V
Sbjct: 342 HTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV--QYDGRRV 396
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK 209
+G ++KVW +T+ + + + +++G+ D + +W V G+C
Sbjct: 397 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 456
Query: 210 TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAAN 269
+ T G L D V G D T++IWD+K G + L+G HQ +TC+ N
Sbjct: 457 HTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 515
Query: 270 QDGSLILTGSVDCQAKLVSATTGKVV 295
+ + ++T S D KL TG+ +
Sbjct: 516 K--NFVITSSDDGTVKLWDLKTGEFI 539
Score = 56.2 bits (134), Expect = 6e-08
Identities = 56/246 (22%), Positives = 101/246 (41%), Gaps = 34/246 (13%)
Query: 189 LLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKR---AVVGYEDGTIRIWDL 244
+++G+ D +W G C +T G G V R + G D T+++W+
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHT-----GGVWSSQMRDNIIISGSTDRTLKVWNA 330
Query: 245 KQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVA 304
+ G IH L G H + C+ ++ +++GS D ++ TG+ + V A
Sbjct: 331 ETGECIHTLYG---HTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAA 385
Query: 305 SQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQL 364
+ +G S G D + ++D T+T H Q + V
Sbjct: 386 VRCVQYDGRRVVS-----------------GAYDFMVKVWDPETETCLHTLQGHTNRVYS 428
Query: 365 LWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKA 424
L G VV + SLD +R+WD TG + GH + L + +++V+ + D
Sbjct: 429 LQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTV 485
Query: 425 KVFCVQ 430
K++ ++
Sbjct: 486 KIWDIK 491
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/204 (25%), Positives = 87/204 (42%), Gaps = 25/204 (12%)
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G R V G +D T+++W G + L GH G + ++ ++I++GS D K+
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTL---VGHTGGVW--SSQMRDNIIISGSTDRTLKV 327
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
+A TG+ + T+ S V S G D TL ++D+
Sbjct: 328 WNAETGECI-----HTLYGHTSTVRCMHLHEKRVVS------------GSRDATLRVWDI 370
Query: 347 ATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDF 406
T H V+ + G VV + + D +V++WD T L +GHT + +
Sbjct: 371 ETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNRV--Y 427
Query: 407 ALSKDASLVVTTSGDHKAKVFCVQ 430
+L D VV+ S D +V+ V+
Sbjct: 428 SLQFDGIHVVSGSLDTSIRVWDVE 451
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 92.0 bits (227), Expect = 9e-19
Identities = 76/291 (26%), Positives = 122/291 (41%), Gaps = 33/291 (11%)
Query: 108 VTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKE 167
V+G +D+ VW G+ L GH V + + ++ +G LKVW +T E
Sbjct: 395 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGE 452
Query: 168 EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPD 226
+ + H +++G+ D +W + G C G C V D
Sbjct: 453 CIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYD 510
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G+R V G D +++WD + + +H L+G L DG +++GS+D ++
Sbjct: 511 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-----DGIHVVSGSLDTSIRV 565
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
TG + T+ SL G E + N + S G D T+ I+D+
Sbjct: 566 WDVETGNCI-----HTLTGHQSLTSGMELKDNILVS------------GNADSTVKIWDI 608
Query: 347 AT----QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 393
T QTL+ +HQS + L + V T S DG V+LWD +TG +
Sbjct: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 657
Score = 85.5 bits (210), Expect = 9e-17
Identities = 78/314 (24%), Positives = 135/314 (42%), Gaps = 34/314 (10%)
Query: 119 WRLSDGELLFECAGHKDSV-TCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDL 177
WR + + GH D V TC F + + +G LKVW T + + +
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422
Query: 178 EWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYED 236
R ++++G+ D +W G+C T G C + KR V G D
Sbjct: 423 GVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRD 480
Query: 237 GTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVG 296
T+R+WD++ G +HVL G H + CV DG +++G+ D K
Sbjct: 481 ATLRVWDIETGQCLHVLMG---HVAAVRCV--QYDGRRVVSGAYDFMVK----------- 524
Query: 297 VFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ 356
V+ PET +L + +N V SL F + ++ G LD ++ ++D+ T H
Sbjct: 525 VWDPETETCLHTL----QGHTNRVYSLQFDGIHVVS--GSLDTSIRVWDVETGNCIHTLT 578
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRG---HTAEILDFALSKDAS 413
+ + E ++ + + D V++WD +TG+ L +G H + + +K +
Sbjct: 579 GHQSLTSGM-ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--N 635
Query: 414 LVVTTSGDHKAKVF 427
V+T+S D K++
Sbjct: 636 FVITSSDDGTVKLW 649
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/206 (27%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+++V C+ L K V+G D VW + G+ L GH +V C +D V
Sbjct: 460 HTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV--QYDGRRV 514
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK 209
+G ++KVW +T+ + + + +++G+ D + +W V G+C
Sbjct: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
Query: 210 TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAAN 269
+ T G L D V G D T++IWD+K G + L+G HQ +TC+ N
Sbjct: 575 HTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 633
Query: 270 QDGSLILTGSVDCQAKLVSATTGKVV 295
+ + ++T S D KL TG+ +
Sbjct: 634 K--NFVITSSDDGTVKLWDLKTGEFI 657
Score = 56.2 bits (134), Expect = 6e-08
Identities = 56/246 (22%), Positives = 101/246 (41%), Gaps = 34/246 (13%)
Query: 189 LLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKR---AVVGYEDGTIRIWDL 244
+++G+ D +W G C +T G G V R + G D T+++W+
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHT-----GGVWSSQMRDNIIISGSTDRTLKVWNA 448
Query: 245 KQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVA 304
+ G IH L G H + C+ ++ +++GS D ++ TG+ + V A
Sbjct: 449 ETGECIHTLYG---HTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAA 503
Query: 305 SQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQL 364
+ +G S G D + ++D T+T H Q + V
Sbjct: 504 VRCVQYDGRRVVS-----------------GAYDFMVKVWDPETETCLHTLQGHTNRVYS 546
Query: 365 LWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKA 424
L G VV + SLD +R+WD TG + GH + L + +++V+ + D
Sbjct: 547 LQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTV 603
Query: 425 KVFCVQ 430
K++ ++
Sbjct: 604 KIWDIK 609
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/204 (25%), Positives = 87/204 (42%), Gaps = 25/204 (12%)
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G R V G +D T+++W G + L GH G + ++ ++I++GS D K+
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTL---VGHTGGVW--SSQMRDNIIISGSTDRTLKV 445
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
+A TG+ + T+ S V S G D TL ++D+
Sbjct: 446 WNAETGECI-----HTLYGHTSTVRCMHLHEKRVVS------------GSRDATLRVWDI 488
Query: 347 ATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDF 406
T H V+ + G VV + + D +V++WD T L +GHT + +
Sbjct: 489 ETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNRV--Y 545
Query: 407 ALSKDASLVVTTSGDHKAKVFCVQ 430
+L D VV+ S D +V+ V+
Sbjct: 546 SLQFDGIHVVSGSLDTSIRVWDVE 569
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 92.0 bits (227), Expect = 9e-19
Identities = 76/291 (26%), Positives = 122/291 (41%), Gaps = 33/291 (11%)
Query: 108 VTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKE 167
V+G +D+ VW G+ L GH V + + ++ +G LKVW +T E
Sbjct: 315 VSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGE 372
Query: 168 EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPD 226
+ + H +++G+ D +W + G C G C V D
Sbjct: 373 CIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQYD 430
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G+R V G D +++WD + + +H L+G L DG +++GS+D ++
Sbjct: 431 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-----DGIHVVSGSLDTSIRV 485
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
TG + T+ SL G E + N + S G D T+ I+D+
Sbjct: 486 WDVETGNCI-----HTLTGHQSLTSGMELKDNILVS------------GNADSTVKIWDI 528
Query: 347 AT----QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLL 393
T QTL+ +HQS + L + V T S DG V+LWD +TG +
Sbjct: 529 KTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI 577
Score = 85.5 bits (210), Expect = 9e-17
Identities = 78/314 (24%), Positives = 135/314 (42%), Gaps = 34/314 (10%)
Query: 119 WRLSDGELLFECAGHKDSV-TCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDL 177
WR + + GH D V TC F + + +G LKVW T + + +
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTG 342
Query: 178 EWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYED 236
R ++++G+ D +W G+C T G C + KR V G D
Sbjct: 343 GVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRD 400
Query: 237 GTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVG 296
T+R+WD++ G +HVL G H + CV DG +++G+ D K
Sbjct: 401 ATLRVWDIETGQCLHVLMG---HVAAVRCV--QYDGRRVVSGAYDFMVK----------- 444
Query: 297 VFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ 356
V+ PET +L + +N V SL F + ++ G LD ++ ++D+ T H
Sbjct: 445 VWDPETETCLHTL----QGHTNRVYSLQFDGIHVVS--GSLDTSIRVWDVETGNCIHTLT 498
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRG---HTAEILDFALSKDAS 413
+ + E ++ + + D V++WD +TG+ L +G H + + +K +
Sbjct: 499 GHQSLTSGM-ELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--N 555
Query: 414 LVVTTSGDHKAKVF 427
V+T+S D K++
Sbjct: 556 FVITSSDDGTVKLW 569
Score = 81.6 bits (200), Expect = 1e-15
Identities = 56/206 (27%), Positives = 94/206 (45%), Gaps = 8/206 (3%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+++V C+ L K V+G D VW + G+ L GH +V C +D V
Sbjct: 380 HTSTVRCMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV--QYDGRRV 434
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK 209
+G ++KVW +T+ + + + +++G+ D + +W V G+C
Sbjct: 435 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 494
Query: 210 TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAAN 269
+ T G L D V G D T++IWD+K G + L+G HQ +TC+ N
Sbjct: 495 HTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN 553
Query: 270 QDGSLILTGSVDCQAKLVSATTGKVV 295
+ + ++T S D KL TG+ +
Sbjct: 554 K--NFVITSSDDGTVKLWDLKTGEFI 577
Score = 56.2 bits (134), Expect = 6e-08
Identities = 56/246 (22%), Positives = 101/246 (41%), Gaps = 34/246 (13%)
Query: 189 LLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKR---AVVGYEDGTIRIWDL 244
+++G+ D +W G C +T G G V R + G D T+++W+
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHT-----GGVWSSQMRDNIIISGSTDRTLKVWNA 368
Query: 245 KQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVA 304
+ G IH L G H + C+ ++ +++GS D ++ TG+ + V A
Sbjct: 369 ETGECIHTLYG---HTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAA 423
Query: 305 SQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQL 364
+ +G S G D + ++D T+T H Q + V
Sbjct: 424 VRCVQYDGRRVVS-----------------GAYDFMVKVWDPETETCLHTLQGHTNRVYS 466
Query: 365 LWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKA 424
L G VV + SLD +R+WD TG + GH + L + +++V+ + D
Sbjct: 467 LQFDGIHVV-SGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADSTV 523
Query: 425 KVFCVQ 430
K++ ++
Sbjct: 524 KIWDIK 529
Score = 53.9 bits (128), Expect = 3e-07
Identities = 52/204 (25%), Positives = 87/204 (42%), Gaps = 25/204 (12%)
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G R V G +D T+++W G + L GH G + ++ ++I++GS D K+
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTL---VGHTGGVW--SSQMRDNIIISGSTDRTLKV 365
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
+A TG+ + T+ S V S G D TL ++D+
Sbjct: 366 WNAETGECI-----HTLYGHTSTVRCMHLHEKRVVS------------GSRDATLRVWDI 408
Query: 347 ATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDF 406
T H V+ + G VV + + D +V++WD T L +GHT + +
Sbjct: 409 ETGQCLHVLMGHVAAVRCVQYDGRRVV-SGAYDFMVKVWDPETETCLHTLQGHTNRV--Y 465
Query: 407 ALSKDASLVVTTSGDHKAKVFCVQ 430
+L D VV+ S D +V+ V+
Sbjct: 466 SLQFDGIHVVSGSLDTSIRVWDVE 489
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 86.3 bits (212), Expect = 5e-17
Identities = 70/309 (22%), Positives = 131/309 (42%), Gaps = 12/309 (3%)
Query: 128 FECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTK--EEVWSFEAGDLEWMEWHPR 185
+ +GH+ VT F +++ + +KVW +T E ++ + +
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
Query: 186 APVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDL 244
+L + +AD +W +C +T G + + ++P+G V D TI++W++
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 245 KQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRP---- 300
+ G + +K GH+ + V NQDG+LI + S D ++ T + R
Sbjct: 222 QTG---YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
Query: 301 -ETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQ 358
E ++ P SE+ E+ P G D T+ ++D++T L H
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
Query: 359 SGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTT 418
+ + +L+ +G + +C+ D +R+WD + R + H + K A VVT
Sbjct: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTG 398
Query: 419 SGDHKAKVF 427
S D KV+
Sbjct: 399 SVDQTVKVW 407
Score = 58.2 bits (139), Expect = 1e-08
Identities = 53/220 (24%), Positives = 89/220 (40%), Gaps = 27/220 (12%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H +V V++ P + + V+ D +W + G + GH++ V + D TL+
Sbjct: 191 HDHNVSSVAIMPNGDHI-VSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLI 249
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGD--LEWMEWHPRA--------------------P 187
A+ ++VW V TKE + +E + W P + P
Sbjct: 250 ASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGP 309
Query: 188 VLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQ 246
LL+G+ D MW V G C T G + GK + +D T+R+WD K
Sbjct: 310 FLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Query: 247 GSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
+K H+ +T + ++ ++TGSVD K+
Sbjct: 370 K---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 43.9 bits (102), Expect = 3e-04
Identities = 35/173 (20%), Positives = 71/173 (41%), Gaps = 16/173 (9%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESES 317
GH+ P+T V + S++++ S D K+ TG + T
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHT--------------- 150
Query: 318 NSVESLGFCSVMPLAAVGYLDGTLAIYDL-ATQTLRHQCQHQSGIVQLLWEAGTAVVYTC 376
+SV+ + F L A D T+ ++D + +R H + + + +
Sbjct: 151 DSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA 210
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCV 429
S D +++W+ +TG + + GH + ++D +L+ + S D +V+ V
Sbjct: 211 SRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263
Score = 40.8 bits (94), Expect = 0.002
Identities = 18/74 (24%), Positives = 37/74 (50%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H+S + ++++ +V+ + S D +++WD TG +GHT + D + L+
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 417 TTSGDHKAKVFCVQ 430
+ S D K++ Q
Sbjct: 167 SCSADMTIKLWDFQ 180
Score = 38.1 bits (87), Expect = 0.016
Identities = 20/94 (21%), Positives = 42/94 (44%), Gaps = 1/94 (1%)
Query: 338 DGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDY 396
D T+ ++D T + H + + ++ ++ +CS D ++LWD + +
Sbjct: 129 DATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTM 188
Query: 397 RGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
GH + A+ + +V+ S D K++ VQ
Sbjct: 189 HGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
Score = 35.8 bits (81), Expect = 0.078
Identities = 22/103 (21%), Positives = 42/103 (40%), Gaps = 2/103 (1%)
Query: 102 KTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW 161
K ++G D +W +S G L GH + V F + + L+VW
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Query: 162 QVDTKEEVWSFEAGD--LEWMEWHPRAPVLLAGTADGNTWMWK 202
K + + A + + +++H AP ++ G+ D +W+
Sbjct: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 84.7 bits (208), Expect = 1e-16
Identities = 47/195 (24%), Positives = 91/195 (46%), Gaps = 6/195 (3%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+++V + L + L TGG+D + +W ++ + GH V + L+
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 150 ATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGD 207
G SG ++VW ++ + + + ++ +++HP + +G+ D N +W +
Sbjct: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
Query: 208 CK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCV 266
C ++G + C R PDGK +D T+++WDL G ++ GH GP+ V
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK---MMSEFPGHTGPVNVV 195
Query: 267 AANQDGSLILTGSVD 281
+ + L+ +GS D
Sbjct: 196 EFHPNEYLLASGSSD 210
Score = 52.4 bits (124), Expect = 8e-07
Identities = 41/163 (25%), Positives = 69/163 (42%), Gaps = 16/163 (9%)
Query: 266 VAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGF 325
V G L+ TG DC+ L S + +P + S ++ VES+
Sbjct: 27 VLGKASGRLLATGGDDCRVNLWS--------INKPNCIMSLTG-------HTSPVESVRL 71
Query: 326 CSVMPLAAVGYLDGTLAIYDL-ATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRL 384
+ L G G++ ++DL A + LR H++ I L + V + S D ++L
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
Query: 385 WDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
WD R + YRGH+ + S D + + + DH K++
Sbjct: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/212 (19%), Positives = 81/212 (38%), Gaps = 31/212 (14%)
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKL 286
G+ G +D + +W + + + I L G H P+ V N LI+ GS ++
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTG---HTSPVESVRLNTPEELIVAGSQSGSIRV 89
Query: 287 VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL 346
K++ ++ SL F A G D + ++D+
Sbjct: 90 WDLEAAKILRTLM---------------GHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
Query: 347 ATQTLRHQCQHQSGIVQLL-------WEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGH 399
+ + + S V+ L W A A +T V+LWD G++++++ GH
Sbjct: 135 RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHT------VKLWDLTAGKMMSEFPGH 188
Query: 400 TAEILDFALSKDASLVVTTSGDHKAKVFCVQR 431
T + + L+ + S D + + +++
Sbjct: 189 TGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/108 (25%), Positives = 49/108 (45%), Gaps = 3/108 (2%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
HS +V C+ P LA + +D +W L+ G+++ E GH V F + L+
Sbjct: 146 HSQAVRCLRFSPDGKWLA-SAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLL 204
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTAD 195
A+G ++ W ++ + V E G + + ++P L +G D
Sbjct: 205 ASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 83.6 bits (205), Expect = 3e-16
Identities = 75/301 (24%), Positives = 130/301 (43%), Gaps = 24/301 (7%)
Query: 126 LLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW-QVDTK-EEVWSFEAGDLEWMEWH 183
L F AGH +V+ FS + +A+ L+K+W D K E+ S + + W
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 184 PRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
+ +L++ + D +W V +G C KT +G + C P V G D ++RIW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 243 DLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPET 302
D+K G LK H P++ V N+DGSLI++ S D G+ R
Sbjct: 157 DVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYD--------------GLCRIWD 199
Query: 303 VASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSG- 360
AS L + ++ V + F LD TL ++D + + L+ H++
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259
Query: 361 --IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTT 418
I G + + S D +V +W+ +T ++ +GHT ++ A +++ +
Sbjct: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319
Query: 419 S 419
+
Sbjct: 320 A 320
Score = 77.0 bits (188), Expect = 3e-14
Identities = 55/219 (25%), Positives = 101/219 (46%), Gaps = 11/219 (5%)
Query: 84 EVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
E T + H + V+ +N L V+ +D +W +S G+ L GH + V C F+
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLL-VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 144 HDSTLVATGDMSGLLKVWQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMW 201
S L+ +G +++W V T + + + A + + ++ ++++ + DG +W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 202 KVPNGDC-KT-FQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGH 259
+G C KT N P + + P+GK + D T+++WD +G LK GH
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK---CLKTYTGH 255
Query: 260 QGPLTCVAAN---QDGSLILTGSVDCQAKLVSATTGKVV 295
+ C+ AN G I++GS D + + T ++V
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Score = 73.9 bits (180), Expect = 3e-13
Identities = 54/216 (25%), Positives = 95/216 (43%), Gaps = 6/216 (2%)
Query: 86 TFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
T A H+ +V V P LA + D +W DG+ +GHK ++ +S D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLA-SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 146 STLVATGDMSGLLKVWQVDTKE--EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKV 203
S L+ + LK+W V + + + + + ++P++ ++++G+ D + +W V
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 204 PNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGP 262
G C KT + P + DG V DG RIWD G + L + P
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPP 216
Query: 263 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVF 298
++ V + +G IL ++D KL + GK + +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 47.0 bits (110), Expect = 3e-05
Identities = 43/181 (23%), Positives = 80/181 (44%), Gaps = 17/181 (9%)
Query: 249 PIHVLKGT-EGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
P + LK T GH ++ V + +G + + S D K+ A GK E S
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF------EKTISGH 86
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLW 366
LG + + + S L D TL I+D+++ + L+ H + + +
Sbjct: 87 KLG---------ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 367 EAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+ ++ + S D VR+WD +TG+ L H+ + ++D SL+V++S D ++
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 427 F 427
+
Sbjct: 198 W 198
Score = 41.6 bits (96), Expect = 0.001
Identities = 17/74 (22%), Positives = 41/74 (55%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H+ GI + W + + ++ + S D +++WD +G+ L +GH+ + + ++L+V
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 417 TTSGDHKAKVFCVQ 430
+ S D +++ V+
Sbjct: 146 SGSFDESVRIWDVK 159
Score = 37.4 bits (85), Expect = 0.027
Identities = 18/53 (33%), Positives = 29/53 (54%)
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCV 429
S D ++++W A G+ GH I D A S D++L+V+ S D K++ V
Sbjct: 64 SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Score = 34.7 bits (78), Expect = 0.17
Identities = 18/83 (21%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 86 TFALHSASVFCV--SLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
T+ H +C+ + V+G ED+ ++W L E++ + GH D V
Sbjct: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 144 HDSTLVATGDMSG--LLKVWQVD 164
++A+ + +K+W+ D
Sbjct: 311 PTENIIASAALENDKTIKLWKSD 333
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 83.6 bits (205), Expect = 3e-16
Identities = 75/301 (24%), Positives = 130/301 (43%), Gaps = 24/301 (7%)
Query: 126 LLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVW-QVDTK-EEVWSFEAGDLEWMEWH 183
L F AGH +V+ FS + +A+ L+K+W D K E+ S + + W
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
Query: 184 PRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
+ +L++ + D +W V +G C KT +G + C P V G D ++RIW
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 243 DLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPET 302
D+K G LK H P++ V N+DGSLI++ S D G+ R
Sbjct: 157 DVKTGK---CLKTLPAHSDPVSAVHFNRDGSLIVSSSYD--------------GLCRIWD 199
Query: 303 VASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSG- 360
AS L + ++ V + F LD TL ++D + + L+ H++
Sbjct: 200 TASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEK 259
Query: 361 --IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTT 418
I G + + S D +V +W+ +T ++ +GHT ++ A +++ +
Sbjct: 260 YCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASA 319
Query: 419 S 419
+
Sbjct: 320 A 320
Score = 77.0 bits (188), Expect = 3e-14
Identities = 55/219 (25%), Positives = 101/219 (46%), Gaps = 11/219 (5%)
Query: 84 EVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
E T + H + V+ +N L V+ +D +W +S G+ L GH + V C F+
Sbjct: 80 EKTISGHKLGISDVAWSSDSNLL-VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFN 138
Query: 144 HDSTLVATGDMSGLLKVWQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMW 201
S L+ +G +++W V T + + + A + + ++ ++++ + DG +W
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 202 KVPNGDC-KT-FQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGH 259
+G C KT N P + + P+GK + D T+++WD +G LK GH
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGK---CLKTYTGH 255
Query: 260 QGPLTCVAAN---QDGSLILTGSVDCQAKLVSATTGKVV 295
+ C+ AN G I++GS D + + T ++V
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Score = 73.9 bits (180), Expect = 3e-13
Identities = 54/216 (25%), Positives = 95/216 (43%), Gaps = 6/216 (2%)
Query: 86 TFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
T A H+ +V V P LA + D +W DG+ +GHK ++ +S D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLA-SSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 146 STLVATGDMSGLLKVWQVDTKE--EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKV 203
S L+ + LK+W V + + + + + ++P++ ++++G+ D + +W V
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 204 PNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGP 262
G C KT + P + DG V DG RIWD G + L + P
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPP 216
Query: 263 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVF 298
++ V + +G IL ++D KL + GK + +
Sbjct: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Score = 47.0 bits (110), Expect = 3e-05
Identities = 43/181 (23%), Positives = 80/181 (44%), Gaps = 17/181 (9%)
Query: 249 PIHVLKGT-EGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
P + LK T GH ++ V + +G + + S D K+ A GK E S
Sbjct: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKF------EKTISGH 86
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLW 366
LG + + + S L D TL I+D+++ + L+ H + + +
Sbjct: 87 KLG---------ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 367 EAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+ ++ + S D VR+WD +TG+ L H+ + ++D SL+V++S D ++
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197
Query: 427 F 427
+
Sbjct: 198 W 198
Score = 41.6 bits (96), Expect = 0.001
Identities = 17/74 (22%), Positives = 41/74 (55%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H+ GI + W + + ++ + S D +++WD +G+ L +GH+ + + ++L+V
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 417 TTSGDHKAKVFCVQ 430
+ S D +++ V+
Sbjct: 146 SGSFDESVRIWDVK 159
Score = 37.4 bits (85), Expect = 0.027
Identities = 18/53 (33%), Positives = 29/53 (54%)
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCV 429
S D ++++W A G+ GH I D A S D++L+V+ S D K++ V
Sbjct: 64 SADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Score = 34.7 bits (78), Expect = 0.17
Identities = 18/83 (21%), Positives = 36/83 (43%), Gaps = 4/83 (4%)
Query: 86 TFALHSASVFCV--SLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
T+ H +C+ + V+G ED+ ++W L E++ + GH D V
Sbjct: 251 TYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACH 310
Query: 144 HDSTLVATGDMSG--LLKVWQVD 164
++A+ + +K+W+ D
Sbjct: 311 PTENIIASAALENDKTIKLWKSD 333
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 82.8 bits (203), Expect = 6e-16
Identities = 71/301 (23%), Positives = 123/301 (40%), Gaps = 24/301 (7%)
Query: 132 GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGD--LEWMEWHPRAPVL 189
GH+D+VTC FS ++ +A+G M L VW + + + F + + + P +L
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 190 LAGTADGNTWMWKVPN--GDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQG 247
+G+ D +W VPN G+ F+ DG+ V +D T+++W +
Sbjct: 77 ASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 248 SPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
+ L H + C + DG LI++ S D KL ++ + V +
Sbjct: 136 KFLFSLSQ---HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY--------- 183
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLW 366
G G C +AA G +D T+ ++D+ T + L+H H + + L +
Sbjct: 184 -CEHGGFVTYVDFHPSGTC----IAAAG-MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 367 EAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+ T S D +++ D GRLL GH A S+ + D + V
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 427 F 427
+
Sbjct: 298 W 298
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/228 (27%), Positives = 98/228 (42%), Gaps = 13/228 (5%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H+A+V V + VT +D VW + LF + H + V CA FS D
Sbjct: 99 FRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L+ + +K+W ++E V S+ G + ++++HP + A D +W V
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 205 NGDCKTFQGPNCPATCGRVL-PDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+ A G P G + D T++I DL +G ++ L GHQGP
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPA 274
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSAT-----TGKVVGVFR-PETVAS 305
T VA ++ G +G D Q + + G+V V R P T+AS
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS 322
Score = 66.6 bits (161), Expect = 4e-11
Identities = 51/221 (23%), Positives = 87/221 (39%), Gaps = 7/221 (3%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H +V CV T LA +G D VW + + GHKD+VTC FS
Sbjct: 15 FKGHRDAVTCVDFSINTKQLA-SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L+A+G +++W + K E F A + + + + + D +W
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 205 NGDCKTFQGPNCP-ATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+ C + PDG+ V +D T+++WD +H H G +
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH---SYCEHGGFV 190
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVA 304
T V + G+ I +D K+ T +++ ++ + A
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 231
Score = 58.9 bits (141), Expect = 9e-09
Identities = 53/244 (21%), Positives = 97/244 (39%), Gaps = 31/244 (12%)
Query: 211 FQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQ 270
F+G TC + K+ G D + +W +K S + GH+ +TCV +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF---TGHKDAVTCVNFSP 71
Query: 271 DGSLILTGSVDCQAKLVSATTGKVVGVFRPE--TVASQPSLGEGEE----SESNSV---- 320
G L+ +GS D ++ VFR TV S +G+ S+ +V
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 321 -----------ESLGFCSVMPLAAVGYL------DGTLAIYDLATQTLRHQ-CQHQSGIV 362
+ + + + G L D T+ ++D +++ H C+H +
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ + + +D V++WD RT RLL Y+ H+A + + + ++T S D
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Query: 423 KAKV 426
K+
Sbjct: 252 TLKI 255
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/129 (23%), Positives = 52/129 (40%), Gaps = 1/129 (0%)
Query: 304 ASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIV 362
A PSL + ++V + F A G +D L ++ + Q+ ++ H+ +
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ + ++ + S D VR+W T +R HTA + D VT S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 423 KAKVFCVQR 431
KV+ R
Sbjct: 126 TVKVWATHR 134
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 82.8 bits (203), Expect = 6e-16
Identities = 71/301 (23%), Positives = 123/301 (40%), Gaps = 24/301 (7%)
Query: 132 GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGD--LEWMEWHPRAPVL 189
GH+D+VTC FS ++ +A+G M L VW + + + F + + + P +L
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 190 LAGTADGNTWMWKVPN--GDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQG 247
+G+ D +W VPN G+ F+ DG+ V +D T+++W +
Sbjct: 77 ASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135
Query: 248 SPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
+ L H + C + DG LI++ S D KL ++ + V +
Sbjct: 136 KFLFSLSQ---HINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY--------- 183
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLW 366
G G C +AA G +D T+ ++D+ T + L+H H + + L +
Sbjct: 184 -CEHGGFVTYVDFHPSGTC----IAAAG-MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 367 EAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+ T S D +++ D GRLL GH A S+ + D + V
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 427 F 427
+
Sbjct: 298 W 298
Score = 79.3 bits (194), Expect = 6e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 26/285 (9%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H+A+V V + VT +D VW + LF + H + V CA FS D
Sbjct: 99 FRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L+ + +K+W ++E V S+ G + ++++HP + A D +W V
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Query: 205 NGDCKTFQGPNCPATCGRVL-PDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+ A G P G + D T++I DL +G ++ L GHQGP
Sbjct: 218 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPA 274
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSAT-----TGKVVGVFR-PETVASQPSLGEGEE--- 314
T VA ++ G +G D Q + + G+V V R P T+AS S+G E
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS--SMGNLPEVDF 332
Query: 315 ----SESNSVESLGFCSVMPLAAVGYLDGTL----AIYDLATQTL 351
SVES+ P++ L TL D+ TQT+
Sbjct: 333 PVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTV 377
Score = 66.6 bits (161), Expect = 4e-11
Identities = 51/221 (23%), Positives = 87/221 (39%), Gaps = 7/221 (3%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H +V CV T LA +G D VW + + GHKD+VTC FS
Sbjct: 15 FKGHRDAVTCVDFSINTKQLA-SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSG 73
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSFEA--GDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L+A+G +++W + K E F A + + + + + D +W
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 205 NGDCKTFQGPNCP-ATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+ C + PDG+ V +D T+++WD +H H G +
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH---SYCEHGGFV 190
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVA 304
T V + G+ I +D K+ T +++ ++ + A
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAA 231
Score = 58.9 bits (141), Expect = 9e-09
Identities = 53/244 (21%), Positives = 97/244 (39%), Gaps = 31/244 (12%)
Query: 211 FQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQ 270
F+G TC + K+ G D + +W +K S + GH+ +TCV +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF---TGHKDAVTCVNFSP 71
Query: 271 DGSLILTGSVDCQAKLVSATTGKVVGVFRPE--TVASQPSLGEGEE----SESNSV---- 320
G L+ +GS D ++ VFR TV S +G+ S+ +V
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 321 -----------ESLGFCSVMPLAAVGYL------DGTLAIYDLATQTLRHQ-CQHQSGIV 362
+ + + + G L D T+ ++D +++ H C+H +
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ + + +D V++WD RT RLL Y+ H+A + + + ++T S D
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Query: 423 KAKV 426
K+
Sbjct: 252 TLKI 255
Score = 40.8 bits (94), Expect = 0.002
Identities = 30/129 (23%), Positives = 52/129 (40%), Gaps = 1/129 (0%)
Query: 304 ASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIV 362
A PSL + ++V + F A G +D L ++ + Q+ ++ H+ +
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ + ++ + S D VR+W T +R HTA + D VT S D
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125
Query: 423 KAKVFCVQR 431
KV+ R
Sbjct: 126 TVKVWATHR 134
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 81.6 bits (200), Expect = 1e-15
Identities = 94/378 (24%), Positives = 143/378 (37%), Gaps = 73/378 (19%)
Query: 100 DPKTNTLAVTGGEDDKAFVWRLSDGELLFEC-AGHKDSVTCAGFSHDSTLVATGDMSGLL 158
DPK N T G K + R D L + H V A ++ +A+GD+SG L
Sbjct: 26 DPKGNNFLYTNG---KCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKL 82
Query: 159 KVWQVDTKEEVWSFE----AG---DLEWMEWHPRAPVLLAGTAD-GNTWMW--------- 201
++W KE + +E AG D+ W E R V+ G G ++W
Sbjct: 83 RIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEI 142
Query: 202 ----KVPNG-DCK--------TFQGPNCPA--------------------TCGRVLPDGK 228
KV N D K T NC A C R PDG
Sbjct: 143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGN 202
Query: 229 RAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVS 288
R DG I I+D K G + L G++ H G + ++ + D + +L+ S D +K+
Sbjct: 203 RFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Query: 289 ATTGKVVGVFRPETVASQPSLG-EGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLA 347
+ VV F + LG ++ SV G+ + YLD L
Sbjct: 263 VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY--------INYLDRNNPSKPL- 313
Query: 348 TQTLRHQCQHQSGIVQLLW---EAGTAVVYTCSLDGIVRLWDARTGRLLT-DYRGHTAEI 403
H + S +Q L G + +Y+ S DG + WD+ TG + +GHT ++
Sbjct: 314 -----HVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQV 368
Query: 404 LDFALSKDASLVVTTSGD 421
+ + L+ + D
Sbjct: 369 SRMTVDESGQLISCSMDD 386
Score = 49.3 bits (116), Expect = 7e-06
Identities = 49/220 (22%), Positives = 80/220 (36%), Gaps = 25/220 (11%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+ + V + TG +D+ A + + F H V C FS D
Sbjct: 145 HNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRF 204
Query: 150 ATGDMSGLLKVWQVDTKEEVWSF-----EAGDLEWMEWHPRAPVLLAGTADGNTWMWKV- 203
AT G + ++ T E+V + G + + W P + LL+ + D + +W V
Sbjct: 205 ATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVS 264
Query: 204 --------PNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKG 255
P G Q C +L + Y D P+HV+K
Sbjct: 265 VNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN------NPSKPLHVIK- 317
Query: 256 TEGHQGPLTCVAANQDG--SLILTGSVDCQAKLVSATTGK 293
GH + C+ +++G S I +GS D + TG+
Sbjct: 318 --GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 355
Score = 32.0 bits (71), Expect = 1.1
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 78 EGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE--LLFECAGHKD 135
+G ++ V + H A + C++ P A +GG D +VW LSD E + + A
Sbjct: 520 DGYSENNVFYG-HHAKIVCLAWSPDNEHFA-SGGMDMMVYVWTLSDPETRVKIQDAHRLH 577
Query: 136 SVTCAGFSHDSTLVATGDMSGLLKVWQV 163
V+ + + TLV T +K W +
Sbjct: 578 HVSSLAWLDEHTLVTTSH-DASVKEWTI 604
Score = 28.9 bits (63), Expect = 9.5
Identities = 41/180 (22%), Positives = 70/180 (38%), Gaps = 17/180 (9%)
Query: 208 CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVA 267
C + P V P G +G DG +R++ + G+ + +GP+T VA
Sbjct: 438 CFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-LGTTLKDEGKLLEAKGPVTDVA 496
Query: 268 ANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCS 327
+ DG+ + C A KVV VF S+ ++ G ++ + L +
Sbjct: 497 YSHDGAFLAV----CDA-------SKVVTVFSVADGYSENNVFYGHHAK---IVCLAWSP 542
Query: 328 VMPLAAVGYLDGTLAIYDLATQTLRHQCQ--HQSGIVQLLWEAGTAVVYTCSLDGIVRLW 385
A G +D + ++ L+ R + Q H+ V L + T S D V+ W
Sbjct: 543 DNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 602
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 79.3 bits (194), Expect = 6e-15
Identities = 78/285 (27%), Positives = 119/285 (41%), Gaps = 26/285 (9%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H+A+V V + VT +D VW + LF + H + V CA FS D
Sbjct: 61 FRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L+ + +K+W ++E V S+ G + ++++HP + A D +W V
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 205 NGDCKTFQGPNCPATCGRVL-PDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+ A G P G + D T++I DL +G ++ L GHQGP
Sbjct: 180 THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL---HGHQGPA 236
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSAT-----TGKVVGVFR-PETVASQPSLGEGEE--- 314
T VA ++ G +G D Q + + G+V V R P T+AS S+G E
Sbjct: 237 TTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLAS--SMGNLPEVDF 294
Query: 315 ----SESNSVESLGFCSVMPLAAVGYLDGTL----AIYDLATQTL 351
SVES+ P++ L TL D+ TQT+
Sbjct: 295 PVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTV 339
Score = 62.8 bits (151), Expect = 6e-10
Identities = 68/318 (21%), Positives = 111/318 (34%), Gaps = 62/318 (19%)
Query: 113 DDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSF 172
D VW + + GHKD+VTC FS
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS----------------------------- 32
Query: 173 EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPN--GDCKTFQGPNCPATCGRVLPDGKRA 230
P +L +G+ D +W VPN G+ F+ DG+
Sbjct: 33 -----------PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 231 VVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSAT 290
V +D T+++W + + L H + C + DG LI++ S D KL +
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQ---HINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 291 TGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-Q 349
+ + V + G G C +AA G +D T+ ++D+ T +
Sbjct: 138 SRECVHSY----------CEHGGFVTYVDFHPSGTC----IAAAG-MDNTVKVWDVRTHR 182
Query: 350 TLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALS 409
L+H H + + L + + T S D +++ D GRLL GH A S
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Query: 410 KDASLVVTTSGDHKAKVF 427
+ + D + V+
Sbjct: 243 RTGEYFASGGSDEQVMVW 260
Score = 34.3 bits (77), Expect = 0.23
Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 1/96 (1%)
Query: 337 LDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTD 395
+D L ++ + Q+ ++ H+ + + + ++ + S D VR+W T
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 396 YRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQR 431
+R HTA + D VT S D KV+ R
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 96
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 78.6 bits (192), Expect = 1e-14
Identities = 56/203 (27%), Positives = 88/203 (43%), Gaps = 7/203 (3%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H+A V V LA T ED VW + L+ H V CA FS D
Sbjct: 98 FKAHTAPVRSVDFSADGQFLA-TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDG 156
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKV- 203
L+ + +K+W K+ V +F G +++++P + + +D +W V
Sbjct: 157 RLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
Query: 204 PNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
N + +Q + C P G + DGT++I DL +G I+ L +GH GP+
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTL---QGHTGPV 273
Query: 264 TCVAANQDGSLILTGSVDCQAKL 286
V+ ++ G L +G D Q L
Sbjct: 274 FTVSFSKGGELFASGGADTQVLL 296
Score = 69.3 bits (168), Expect = 6e-12
Identities = 73/340 (21%), Positives = 120/340 (35%), Gaps = 67/340 (19%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H A++ + L P LA T D +W + GHKD VT FS
Sbjct: 14 FKGHKAAITSLDLSPNGKQLA-TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG 72
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNG 206
L+A+ +++W D + G
Sbjct: 73 NLLASASRDRTVRLWIPDKR---------------------------------------G 93
Query: 207 DCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCV 266
F+ P DG+ ED +I++W + + ++ L H + C
Sbjct: 94 KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSL---YRHTHWVRCA 150
Query: 267 AANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFC 326
+ DG LI++ S D K+ T + V F S+SV F
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF------------------SDSVGFANFV 192
Query: 327 SVMP----LAAVGYLDGTLAIYDL-ATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGI 381
P +A+ G D T+ ++D+ + L+H H G+ + + + T S DG
Sbjct: 193 DFNPSGTCIASAG-SDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 382 VRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGD 421
+++ D GRL+ +GHT + + SK L + D
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGAD 291
Score = 48.1 bits (113), Expect = 2e-05
Identities = 57/299 (19%), Positives = 103/299 (34%), Gaps = 64/299 (21%)
Query: 132 GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGD--LEWMEWHPRAPVL 189
GHK ++T S + +AT L +W + + + +++ P +L
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 190 LAGTADGNTWMWKVPN--GDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQG 247
+ + D +W +P+ G F+ P DG+ ED +I++W + +
Sbjct: 76 ASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 248 SPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
++ L H + C + DG LI++ S D K+ T + V F
Sbjct: 135 RFLYSLYR---HTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF--------- 182
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWE 367
S+SV F P
Sbjct: 183 ---------SDSVGFANFVDFNP------------------------------------- 196
Query: 368 AGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+GT + S D V++WD R +LL Y+ H+ + + + ++T S D K+
Sbjct: 197 SGTCIASAGS-DQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 42.0 bits (97), Expect = 0.001
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
+ +HS V C+S P N L +T D + L +G L++ GH V FS
Sbjct: 224 YQVHSGGVNCISFHPSGNYL-ITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282
Query: 147 TLVATGDMSGLLKVWQVDTKE 167
L A+G + +W+ + E
Sbjct: 283 ELFASGGADTQVLLWRTNFDE 303
Score = 33.9 bits (76), Expect = 0.30
Identities = 18/75 (24%), Positives = 33/75 (44%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H+ + + + ++ + S D VRLW ++++ HTA + S D +
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118
Query: 417 TTSGDHKAKVFCVQR 431
T S D KV+ + R
Sbjct: 119 TASEDKSIKVWSMYR 133
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 77.0 bits (188), Expect = 3e-14
Identities = 81/327 (24%), Positives = 126/327 (38%), Gaps = 41/327 (12%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H + +SL P L +TG ED A +W +DG+ GH+ VT ++
Sbjct: 14 HRGGINWLSLSPDGQRL-LTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFT 72
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGD-C 208
+ D + ++ W V T + + + L + + D +W V G
Sbjct: 73 CSADCT--IRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMS 130
Query: 209 KTFQG-PNCPAT-------------CGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLK 254
+ F+G NC T C G V G DGT ++W + G L+
Sbjct: 131 REFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLR 190
Query: 255 GTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEE 314
GH G + C+ + G TGS D + +G+ + VFR
Sbjct: 191 ---GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR--------------- 232
Query: 315 SESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSGIVQLLWEAGTAVV 373
SV L V L G D T+ + T + +R H+ + L + AGT +
Sbjct: 233 EHRGSVICLEL--VNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--L 288
Query: 374 YTCSLDGIVRLWDARTGRLLTDYRGHT 400
+T S D R +DA++G L +RGHT
Sbjct: 289 FTGSGDACARAFDAQSGELRRVFRGHT 315
Score = 64.3 bits (155), Expect = 2e-10
Identities = 69/266 (25%), Positives = 106/266 (39%), Gaps = 38/266 (14%)
Query: 175 GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGD-CKTFQGPNCPATCGRVLPDGKRAVVG 233
G + W+ P LL G+ DG +W +G C QG T ++ + + A
Sbjct: 16 GGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTC 73
Query: 234 YEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGK 293
D TIR WD+ G + V +G + VA NQ + + S D A++ S G+
Sbjct: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVNRI-LVANNQ----LFSSSYDRTARVWSVDKGQ 128
Query: 294 VVGVFRPE-----TVA-----SQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAI 343
+ FR T+A PS EE+ + L G DGT +
Sbjct: 129 MSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGG-----------LLVTGSTDGTAKV 177
Query: 344 YDLAT----QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGH 399
+ +A+ QTLR H ++ L+ + +T S D +R WD +G L +R H
Sbjct: 178 WQVASGCCHQTLR---GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREH 234
Query: 400 TAEILDFALSKDASLVVTTSGDHKAK 425
++ L LV + S D K
Sbjct: 235 RGSVICLELVN--RLVYSGSADRTVK 258
Score = 62.8 bits (151), Expect = 6e-10
Identities = 73/320 (22%), Positives = 115/320 (35%), Gaps = 34/320 (10%)
Query: 124 GELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWH 183
G L CA H+ + S D + TG G ++W + + +
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64
Query: 184 PRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIW 242
+AD W V G C + ++G + R+L + D T R+W
Sbjct: 65 LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHT--SIVNRILVANNQLFSSSYDRTARVW 122
Query: 243 DLKQGSPIHVLKG------TEGHQGP-----LTCVAANQDGSLILTGSVDCQAKLVSATT 291
+ +G +G T + P C G L++TGS D AK+ +
Sbjct: 123 SVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVAS 182
Query: 292 GKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYD-LATQT 350
G R T +V L + A G D T+ +D L+ +
Sbjct: 183 GCCHQTLRGHT---------------GAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQ 227
Query: 351 LRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSK 410
LR +H+ ++ L E +VY+ S D V+ W A TG + + H + AL
Sbjct: 228 LRVFREHRGSVICL--ELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNV--SALKY 283
Query: 411 DASLVVTTSGDHKAKVFCVQ 430
A + T SGD A+ F Q
Sbjct: 284 HAGTLFTGSGDACARAFDAQ 303
Score = 44.7 bits (104), Expect = 2e-04
Identities = 43/184 (23%), Positives = 71/184 (38%), Gaps = 12/184 (6%)
Query: 106 LAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
L VTG D A VW+++ G GH +V C TG ++ W + +
Sbjct: 165 LLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILS 224
Query: 166 KEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGR 222
E++ F G + +E R ++ +G+AD W G+C +TF
Sbjct: 225 GEQLRVFREHRGSVICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHR--RNVSA 280
Query: 223 VLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDC 282
+ G D R +D + G V + GH + C+ + G ++ T S D
Sbjct: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFR---GHTFIINCIQVH--GQVLYTASHDG 335
Query: 283 QAKL 286
+L
Sbjct: 336 ALRL 339
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/173 (23%), Positives = 66/173 (38%), Gaps = 60/173 (34%)
Query: 259 HQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESN 318
H+G + ++ + DG +LTGS D A+L S G+ + +G ES
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALL------------QGHESY-- 59
Query: 319 SVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSL 378
+ FC + AA +TCS
Sbjct: 60 ----VTFCQLEDEAA----------------------------------------FTCSA 75
Query: 379 DGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQR 431
D +R WD TG+ L YRGHT+ + ++ + + ++S D A+V+ V +
Sbjct: 76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDK 126
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 77.0 bits (188), Expect = 3e-14
Identities = 55/219 (25%), Positives = 102/219 (46%), Gaps = 11/219 (5%)
Query: 84 EVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
E T H+ + V+ ++ L V+ +D +W + G+ L GH + V C F+
Sbjct: 76 EKTLYGHNLEISDVAWSSDSSRL-VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN 134
Query: 144 HDSTLVATGDMSGLLKVWQVDTKE--EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMW 201
S L+ +G +K+W+V T + + S + + + ++ ++++G+ DG +W
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Query: 202 KVPNGDC-KTF-QGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGH 259
+G C KT N P + + P+GK + D T+++WD +G LK GH
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRG---RCLKTYTGH 251
Query: 260 QGPLTCVAAN---QDGSLILTGSVDCQAKLVSATTGKVV 295
+ C+ AN G I++GS D + + T ++V
Sbjct: 252 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
Score = 77.0 bits (188), Expect = 3e-14
Identities = 48/199 (24%), Positives = 92/199 (46%), Gaps = 11/199 (5%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
HS VFC + +P +N L ++G D+ +W + G+ L + H D V+ F+ +L+
Sbjct: 124 HSNYVFCCNFNPPSN-LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLI 182
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGD---LEWMEWHPRAPVLLAGTADGNTWMWKVPNG 206
+G GL ++W + + + + D + ++++ P +L T D +W G
Sbjct: 183 VSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRG 242
Query: 207 DC-KTFQGPNCPATC---GRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGP 262
C KT+ G C + GK V G ED + IW+L+ +++ +GH
Sbjct: 243 RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK---EIVQKLQGHTDV 299
Query: 263 LTCVAANQDGSLILTGSVD 281
+ A + +LI + +++
Sbjct: 300 VISAACHPTENLIASAALE 318
Score = 76.3 bits (186), Expect = 5e-14
Identities = 69/298 (23%), Positives = 126/298 (42%), Gaps = 30/298 (10%)
Query: 132 GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQV-DTKEEVWSF----EAGDLEWMEWHPRA 186
GH ++V+ FS + +A+ L+ +W D K E + E D+ W R
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR- 97
Query: 187 PVLLAGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLK 245
L++ + D +W V +G C KT +G + C P + G D T++IW++K
Sbjct: 98 --LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 246 QGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAS 305
G LK H P++ V N GSLI++GS D ++ A +G+ +
Sbjct: 156 TGK---CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------- 205
Query: 306 QPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLAT-QTLRHQCQHQSG---I 361
+ ++ V + F LD TL ++D + + L+ H++ I
Sbjct: 206 -------VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCI 258
Query: 362 VQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTS 419
G + + S D +V +W+ +T ++ +GHT ++ A +L+ + +
Sbjct: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 67.0 bits (162), Expect = 3e-11
Identities = 51/216 (23%), Positives = 92/216 (42%), Gaps = 6/216 (2%)
Query: 86 TFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
T H+ +V V P LA + D +W DG+ GH ++ +S D
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLA-SSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD 94
Query: 146 STLVATGDMSGLLKVWQVDTKE--EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKV 203
S+ + + LK+W V + + + + + ++P + ++++G+ D +W+V
Sbjct: 95 SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Query: 204 PNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGP 262
G C KT + P + G V G DG RIWD G + L + P
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL--VDDDNPP 212
Query: 263 LTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVF 298
++ V + +G ILT ++D KL + G+ + +
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Score = 40.4 bits (93), Expect = 0.003
Identities = 18/74 (24%), Positives = 40/74 (54%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H I + W + ++ + + S D ++LWD R+G+ L +GH+ + + ++L++
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141
Query: 417 TTSGDHKAKVFCVQ 430
+ S D K++ V+
Sbjct: 142 SGSFDETVKIWEVK 155
Score = 36.2 bits (82), Expect = 0.060
Identities = 19/54 (35%), Positives = 29/54 (53%)
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
S D ++ +W A G+ GH EI D A S D+S +V+ S D K++ V+
Sbjct: 60 SADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVR 113
Score = 32.3 bits (72), Expect = 0.86
Identities = 19/91 (20%), Positives = 45/91 (49%), Gaps = 1/91 (1%)
Query: 338 DGTLAIYDLAT-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDY 396
D TL ++D+ + + L+ H + + + + ++ + S D V++W+ +TG+ L
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 397 RGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
H+ + + SL+V+ S D +++
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 75.5 bits (184), Expect = 9e-14
Identities = 56/206 (27%), Positives = 85/206 (41%), Gaps = 11/206 (5%)
Query: 89 LHSASV---FCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
LHSAS+ + L P +TGG D V+ S ++L GH VT F
Sbjct: 216 LHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPS 275
Query: 146 STLVATGDMSGLLKVWQVDTKEEVWSFEAGD--LEWMEWHPRAPVLLAGTADGNTWMWKV 203
LV + +++W V V A + + + H LL+ + D +
Sbjct: 276 QDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDI 335
Query: 204 PNGDC---KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQ 260
G T + C TC + PDG G D I+IWDLK+ + + GH
Sbjct: 336 QTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNV---ANFPGHS 392
Query: 261 GPLTCVAANQDGSLILTGSVDCQAKL 286
GP+T +A +++G + T + D KL
Sbjct: 393 GPITSIAFSENGYYLATAADDSSVKL 418
Score = 36.6 bits (83), Expect = 0.046
Identities = 49/244 (20%), Positives = 88/244 (36%), Gaps = 58/244 (23%)
Query: 189 LLAGTADGNTWMW-KVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQG 247
+L G AD N ++ K T +G T P D TIRIW +
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 248 SPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQP 307
S + V++ H+ +T ++ + G +L+ S D TG+V+ ET
Sbjct: 297 SCVQVVRA---HESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSG--- 350
Query: 308 SLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWE 367
CS+ T A + H G L++
Sbjct: 351 ------------------CSL-----------TCAQF------------HPDG---LIFG 366
Query: 368 AGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVF 427
GT +D +++WD + + ++ GH+ I A S++ + T + D K++
Sbjct: 367 TGT-------MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLW 419
Query: 428 CVQR 431
+++
Sbjct: 420 DLRK 423
Score = 32.3 bits (72), Expect = 0.86
Identities = 19/81 (23%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 83 SEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGF 142
++VT S+ C P + TG D + +W L + + GH +T F
Sbjct: 342 TKVTDETSGCSLTCAQFHPD-GLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAF 400
Query: 143 SHDSTLVATGDMSGLLKVWQV 163
S + +AT +K+W +
Sbjct: 401 SENGYYLATAADDSSVKLWDL 421
Score = 31.2 bits (69), Expect = 1.9
Identities = 28/154 (18%), Positives = 61/154 (39%), Gaps = 5/154 (3%)
Query: 270 QDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFC-SV 328
QD + +LT + K V K + + VAS L + + +L C S
Sbjct: 177 QDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGL---HSASIPGILALDLCPSD 233
Query: 329 MPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDA 387
G D + ++D +++ + + H + +++ +V++ S D +R+W
Sbjct: 234 TNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293
Query: 388 RTGRLLTDYRGHTAEILDFALSKDASLVVTTSGD 421
+ R H + + +L ++++S D
Sbjct: 294 PNASCVQVVRAHESAVTGLSLHATGDYLLSSSDD 327
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 75.5 bits (184), Expect = 9e-14
Identities = 78/365 (21%), Positives = 147/365 (40%), Gaps = 82/365 (22%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H ++V+CV+ D +T TG +D +W +G LL GH ++ ++++T++
Sbjct: 185 HLSAVYCVAFD-RTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFE--AGDLEWMEWHPRAP----VLLAGTADGNTWMWKV 203
A G +++VW + T V + G + +++ P A +++ ADG W+
Sbjct: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ- 302
Query: 204 PNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLK--QGSPIHVLKGTEGHQG 261
WDL+ + SP LK TE +
Sbjct: 303 --------------------------------------WDLESLKFSP-RPLKFTEKPRP 323
Query: 262 --PLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNS 319
+ C + + G + TGS D ++ +G PE +A ES ++
Sbjct: 324 GVQMLCSSFSVGGMFLATGSTDHVIRMY------FLGFEAPEKIAEL-------ESHTDK 370
Query: 320 VESLGFCSVMPLAAVGYLDGTLAIY------------DLATQ-----TLRHQCQHQSGIV 362
V+S+ FC+ G DGT I+ D+AT+ + + + +
Sbjct: 371 VDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVT 430
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ W ++V T D ++++W++ TG+LL + GH E+ S ++ ++G H
Sbjct: 431 MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAG-H 489
Query: 423 KAKVF 427
+F
Sbjct: 490 DGSIF 494
Score = 49.7 bits (117), Expect = 5e-06
Identities = 23/74 (31%), Positives = 44/74 (59%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H S + + ++ ++T S D +V++W GRLL+ RGH+AEI D A++ + +++
Sbjct: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
Query: 417 TTSGDHKAKVFCVQ 430
S D +V+C++
Sbjct: 245 AGSCDKIIRVWCLR 258
Score = 35.0 bits (79), Expect = 0.13
Identities = 16/42 (38%), Positives = 23/42 (54%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFR 299
GH + CVA ++ G I TGS DC K+ S G+++ R
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLR 225
>gi|16445436 bromodomain and WD repeat domain containing 1 isoform A
[Homo sapiens]
Length = 2320
Score = 75.5 bits (184), Expect = 9e-14
Identities = 78/365 (21%), Positives = 147/365 (40%), Gaps = 82/365 (22%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H ++V+CV+ D +T TG +D +W +G LL GH ++ ++++T++
Sbjct: 185 HLSAVYCVAFD-RTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMI 243
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFE--AGDLEWMEWHPRAP----VLLAGTADGNTWMWKV 203
A G +++VW + T V + G + +++ P A +++ ADG W+
Sbjct: 244 AAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQ- 302
Query: 204 PNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLK--QGSPIHVLKGTEGHQG 261
WDL+ + SP LK TE +
Sbjct: 303 --------------------------------------WDLESLKFSP-RPLKFTEKPRP 323
Query: 262 --PLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNS 319
+ C + + G + TGS D ++ +G PE +A ES ++
Sbjct: 324 GVQMLCSSFSVGGMFLATGSTDHVIRMY------FLGFEAPEKIAEL-------ESHTDK 370
Query: 320 VESLGFCSVMPLAAVGYLDGTLAIY------------DLATQ-----TLRHQCQHQSGIV 362
V+S+ FC+ G DGT I+ D+AT+ + + + +
Sbjct: 371 VDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVT 430
Query: 363 QLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDH 422
+ W ++V T D ++++W++ TG+LL + GH E+ S ++ ++G H
Sbjct: 431 MIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAG-H 489
Query: 423 KAKVF 427
+F
Sbjct: 490 DGSIF 494
Score = 49.7 bits (117), Expect = 5e-06
Identities = 23/74 (31%), Positives = 44/74 (59%)
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
H S + + ++ ++T S D +V++W GRLL+ RGH+AEI D A++ + +++
Sbjct: 185 HLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIA 244
Query: 417 TTSGDHKAKVFCVQ 430
S D +V+C++
Sbjct: 245 AGSCDKIIRVWCLR 258
Score = 35.0 bits (79), Expect = 0.13
Identities = 16/42 (38%), Positives = 23/42 (54%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFR 299
GH + CVA ++ G I TGS DC K+ S G+++ R
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLR 225
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 74.3 bits (181), Expect = 2e-13
Identities = 65/290 (22%), Positives = 121/290 (41%), Gaps = 34/290 (11%)
Query: 108 VTGGEDDKAFVWRLSDG--ELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDT 165
VTG DD VW+ D +L + GH+ V SH + A+ + +++W ++
Sbjct: 36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLEN 95
Query: 166 KEEVWSFEAGDLE-W-MEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRV 223
+++ S +AG ++ W + + P + L GT G ++ V +G + T G+
Sbjct: 96 GKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESG-----KKEYSLDTRGKF 150
Query: 224 L------PDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILT 277
+ PDGK G DG I I+D+ G +H L EGH P+ + + D L++T
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL---EGHAMPIRSLTFSPDSQLLVT 207
Query: 278 GSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYL 337
S D K+ + G ++ V ++ FC
Sbjct: 208 ASDDGYIKIYDVQHANLAGTL---------------SGHASWVLNVAFCPDDTHFVSSSS 252
Query: 338 DGTLAIYDLATQTLRHQ-CQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWD 386
D ++ ++D+ T+T H HQ + + + + + + D + ++D
Sbjct: 253 DKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 65.1 bits (157), Expect = 1e-10
Identities = 74/314 (23%), Positives = 124/314 (39%), Gaps = 66/314 (21%)
Query: 124 GELLFECAGHKDSVTCAGFS----HDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEW 179
G L + H D++ + +S V TG + L+KVW+ W E DL+W
Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWK-------WRDERLDLQW 58
Query: 180 -MEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVVGYEDGT 238
+E H V + LP + + D
Sbjct: 59 SLEGHQLGVVSV----------------------------DISHTLPIAASSSL---DAH 87
Query: 239 IRIWDLKQGSPIHVLKGTEGHQGPLTC--VAANQDGSLILTGSVDCQAKLVSATTGKVVG 296
IR+WDL+ G I + GP+ +A + D + TG+ GKV
Sbjct: 88 IRLWDLENGKQIKSIDA-----GPVDAWTLAFSPDSQYLATGT----------HVGKV-N 131
Query: 297 VFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ 356
+F E+ + SL ++ + S+ + A G +DG + I+D+AT L H +
Sbjct: 132 IFGVESGKKEYSL----DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE 187
Query: 357 -HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLV 415
H I L + + ++ T S DG ++++D + L GH + +L+ A D +
Sbjct: 188 GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF 247
Query: 416 VTTSGDHKAKVFCV 429
V++S D KV+ V
Sbjct: 248 VSSSSDKSVKVWDV 261
Score = 48.9 bits (115), Expect = 9e-06
Identities = 43/206 (20%), Positives = 84/206 (40%), Gaps = 17/206 (8%)
Query: 226 DGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAK 285
+ + V G D +++W + + + EGHQ + V + + + S+D +
Sbjct: 31 NSETVVTGSLDDLVKVWKWRD-ERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIR 89
Query: 286 LVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYD 345
L GK + +++ + P +L F A G G + I+
Sbjct: 90 LWDLENGKQI-----KSIDAGPV----------DAWTLAFSPDSQYLATGTHVGKVNIFG 134
Query: 346 LATQTLRHQCQHQSG-IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEIL 404
+ + + + I+ + + + + ++DGI+ ++D TG+LL GH I
Sbjct: 135 VESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
Query: 405 DFALSKDASLVVTTSGDHKAKVFCVQ 430
S D+ L+VT S D K++ VQ
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQ 220
Score = 31.2 bits (69), Expect = 1.9
Identities = 20/83 (24%), Positives = 34/83 (40%), Gaps = 1/83 (1%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H+ + ++ P + L VT +D ++ + L +GH V F D T
Sbjct: 189 HAMPIRSLTFSPDSQLL-VTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHF 247
Query: 150 ATGDMSGLLKVWQVDTKEEVWSF 172
+ +KVW V T+ V +F
Sbjct: 248 VSSSSDKSVKVWDVGTRTCVHTF 270
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 73.9 bits (180), Expect = 3e-13
Identities = 60/257 (23%), Positives = 105/257 (40%), Gaps = 22/257 (8%)
Query: 175 GDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVG 233
G++ + P +LL G+ DG + W+ +G G P R PDG
Sbjct: 22 GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASA 81
Query: 234 YEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGK 293
D T+R+WD+ + + VLKG HQ + V+ + D + +G D + L +G+
Sbjct: 82 SCDCTVRLWDVARAKCLRVLKG---HQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 294 VVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDL--ATQTL 351
++ + +S++S F + A G D T+ I+DL T +
Sbjct: 139 MLRLL---------------VGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAV 183
Query: 352 RHQC-QHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSK 410
HQ + S + L + + ++ + S D + +W T LL +GH + A S
Sbjct: 184 SHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Query: 411 DASLVVTTSGDHKAKVF 427
D + + KV+
Sbjct: 244 DELWLASAGYSRMVKVW 260
Score = 70.5 bits (171), Expect = 3e-12
Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 5/212 (2%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H V + P L +TG ED + W G+LL+ GH V FS D
Sbjct: 17 FGQHGGEVNSSAFSPDGQML-LTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDG 75
Query: 147 TLVATGDMSGLLKVWQVDTKE--EVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVP 204
L A+ +++W V + V +E + + P + L +G D +W V
Sbjct: 76 HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQ 135
Query: 205 NGD-CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPL 263
+G + G P G D T+ IWDL+ +P + EGH +
Sbjct: 136 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI 195
Query: 264 TCVAANQDGSLILTGSVDCQAKLVSATTGKVV 295
+C+ + G L+ +GS D + TT ++
Sbjct: 196 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLL 226
Score = 63.5 bits (153), Expect = 3e-10
Identities = 59/293 (20%), Positives = 117/293 (39%), Gaps = 20/293 (6%)
Query: 133 HKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLL 190
H V + FS D ++ TG G + W+ + + +W G +++ + P +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 191 AGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSP 249
+ + D +W V C + +G PD ++ G D + +WD++ G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 250 IHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSL 309
+ +L G H+ + + + + TGS D +T + + S +L
Sbjct: 140 LRLLVG---HRDSIQSSDFSPTVNCLATGSWD--------STVHIWDLRMVTPAVSHQAL 188
Query: 310 GEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEA 368
E S ++ L + S L A G D T+ I+ T +L Q + H + + + +
Sbjct: 189 ----EGHSANISCLCY-SASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Query: 369 GTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGD 421
+ + +V++WD TG+ L +G A + D ++V+ + D
Sbjct: 244 DELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 58.9 bits (141), Expect = 9e-09
Identities = 52/214 (24%), Positives = 86/214 (40%), Gaps = 23/214 (10%)
Query: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLV 149
H SV VS P + LA +GG D + +W + G++L GH+DS+ + FS +
Sbjct: 104 HQRSVETVSFSPDSRQLA-SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCL 162
Query: 150 ATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWH---------PRAPVLLAGTADGNTWM 200
ATG + +W + S +A +E H + +L +G+ D +
Sbjct: 163 ATGSWDSTVHIWDLRMVTPAVSHQA-----LEGHSANISCLCYSASGLLASGSWDKTIHI 217
Query: 201 WKVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGT--E 257
WK +G PD +++WD G + LKG
Sbjct: 218 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDV 277
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATT 291
H TC A DG ++++G+ D + +S T+
Sbjct: 278 AH----TC-AFTPDGKILVSGAADQTRRQISRTS 306
Score = 36.6 bits (83), Expect = 0.046
Identities = 24/86 (27%), Positives = 39/86 (45%)
Query: 346 LATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILD 405
LA + ++ QH + + ++ T S DG V W+ R+G+LL GHT +
Sbjct: 9 LAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKF 68
Query: 406 FALSKDASLVVTTSGDHKAKVFCVQR 431
S D L + S D +++ V R
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVAR 94
Score = 31.6 bits (70), Expect = 1.5
Identities = 23/82 (28%), Positives = 33/82 (40%), Gaps = 14/82 (17%)
Query: 363 QLLWEAG--TAVVYTC------------SLDGIVRLWDARTGRLLTDYRGHTAEILDFAL 408
QLLW G T V C S D VRLWD + L +GH + +
Sbjct: 54 QLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF 113
Query: 409 SKDASLVVTTSGDHKAKVFCVQ 430
S D+ + + D + ++ VQ
Sbjct: 114 SPDSRQLASGGWDKRVMLWDVQ 135
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 72.4 bits (176), Expect = 8e-13
Identities = 80/360 (22%), Positives = 140/360 (38%), Gaps = 62/360 (17%)
Query: 73 VVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE------- 125
V G +E P + V H + VF + +P ++ LA +G D A +W LS+
Sbjct: 151 VDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLA-SGSGDSTARIWNLSENSTSGSTQL 209
Query: 126 LLFECA--GHKD-----SVTCAGFSHDSTLVATGDMSGLLKVWQVDTK-EEVWSFEAGDL 177
+L C G +D VT ++ + TL+ATG G ++W D G +
Sbjct: 210 VLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPI 269
Query: 178 EWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKT-------------FQGPNCPATCGRVL 224
++W+ + +L+ D T +W G+ K +Q N A+C
Sbjct: 270 FALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCST-- 327
Query: 225 PDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQA 284
D I + L Q PI K +GH + + + G+L+ + S D
Sbjct: 328 -----------DMCIHVCKLGQDRPI---KTFQGHTNEVNAIKWDPTGNLLASCSDDMTL 373
Query: 285 KLVSATTGKVVGVFRPE-----TVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDG 339
K+ S V + T+ P+ G G + + ++ + A D
Sbjct: 374 KIWSMKQDNCVHDLQAHNKEIYTIKWSPT-GPGTNNPNANL----------MLASASFDS 422
Query: 340 TLAIYDLATQTLRHQC-QHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRG 398
T+ ++D+ H +HQ + + + + + S D V +W+ +TG L+ YRG
Sbjct: 423 TVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
Score = 52.4 bits (124), Expect = 8e-07
Identities = 48/211 (22%), Positives = 82/211 (38%), Gaps = 14/211 (6%)
Query: 82 DSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAG 141
+++ F HSA + +D ++N + D V +L + GH + V
Sbjct: 299 EAKQQFPFHSAPA--LDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIK 356
Query: 142 FSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLE--WMEWHPRAP---------VLL 190
+ L+A+ LK+W + V +A + E ++W P P +L
Sbjct: 357 WDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLA 416
Query: 191 AGTADGNTWMWKVPNGDC-KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSP 249
+ + D +W V G C T P PDG+ G D + IW+ + G+
Sbjct: 417 SASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGAL 476
Query: 250 IHVLKGTEGHQGPLTCVAANQDGSLILTGSV 280
+H +GT G A ++ G+ GSV
Sbjct: 477 VHSYRGTGGIFEVCWNAAGDKVGASASDGSV 507
Score = 48.9 bits (115), Expect = 9e-06
Identities = 68/301 (22%), Positives = 105/301 (34%), Gaps = 57/301 (18%)
Query: 182 WHPRAPVLLAGTADGNTWMWKVPNGD-----------CKTFQGPNCPATCGRVLPD---- 226
W+P + +L +G+ D +W + C G + P+ D
Sbjct: 177 WNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSE 236
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEG-HQGPLTCVAANQDGSLILTGSVDCQAK 285
G G DG RIW K G+ L T G H+GP+ + N+ G+ IL+ VD
Sbjct: 237 GTLLATGSYDGFARIWT-KDGN----LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTI 291
Query: 286 LVSATTGKVVGVF-------------RPETVASQPS--------LGEGE-----ESESNS 319
+ A TG+ F T AS + LG+ + +N
Sbjct: 292 IWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNE 351
Query: 320 VESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEA---------G 369
V ++ + L A D TL I+ + H Q H I + W
Sbjct: 352 VNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNA 411
Query: 370 TAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCV 429
++ + S D VRLWD G + H + A S D + + S D ++
Sbjct: 412 NLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNT 471
Query: 430 Q 430
Q
Sbjct: 472 Q 472
Score = 46.2 bits (108), Expect = 6e-05
Identities = 39/149 (26%), Positives = 59/149 (39%), Gaps = 3/149 (2%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESES 317
GH+ + A N L+ +GS D A++ + + G + V G++ S
Sbjct: 167 GHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSG--STQLVLRHCIREGGQDVPS 224
Query: 318 NS-VESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTC 376
N V SL + S L A G DG I+ QH+ I L W + +
Sbjct: 225 NKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILD 405
+D +WDA TG + H+A LD
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALD 313
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/217 (23%), Positives = 89/217 (41%), Gaps = 41/217 (18%)
Query: 233 GYEDGTIRIWDLKQ----GSPIHVLKGT--EGHQG-----PLTCVAANQDGSLILTGSVD 281
G D T RIW+L + GS VL+ EG Q +T + N +G+L+ TGS D
Sbjct: 187 GSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYD 246
Query: 282 CQAKL------VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVG 335
A++ +++T G+ G P + N + S G
Sbjct: 247 GFARIWTKDGNLASTLGQHKG----------PIFALKWNKKGNFILSAG----------- 285
Query: 336 YLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLT 394
+D T I+D T + Q H + + + W++ +CS D + + R +
Sbjct: 286 -VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA-SCSTDMCIHVCKLGQDRPIK 343
Query: 395 DYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQR 431
++GHT E+ +L+ + S D K++ +++
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ 380
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 68.6 bits (166), Expect = 1e-11
Identities = 56/307 (18%), Positives = 120/307 (39%), Gaps = 33/307 (10%)
Query: 131 AGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSF---EAGDLEWMEWHPRAP 187
+GH+ V C F + + +A+ L+ +W V + ++ +G + + ++
Sbjct: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGS 122
Query: 188 VLLAGTADGNTWMWKVPNGD-CKTFQG-PNCPATCGRVLPDGKRAVVGYEDGTIRIWDLK 245
+L + + D +W G+ K +G + +C + G +DGT+++WD++
Sbjct: 123 MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIR 182
Query: 246 QGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAS 305
+ + I + T + V N I++G +D K+ K+ R
Sbjct: 183 KKAAIQTFQNTY----QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR------ 232
Query: 306 QPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQC---------Q 356
++SV L S +D T+ ++D+ + +C
Sbjct: 233 ---------GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
Query: 357 HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVV 416
+ +++ W + + S D V +WD + R+L GH I + A D +++
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIII 343
Query: 417 TTSGDHK 423
+ S D +
Sbjct: 344 SASSDKR 350
Score = 54.7 bits (130), Expect = 2e-07
Identities = 48/211 (22%), Positives = 90/211 (42%), Gaps = 16/211 (7%)
Query: 220 CGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGS 279
C + P+G D I +W++ + +GH G + + N DGS+
Sbjct: 71 CCKFHPNGSTLASAGFDRLILLWNVYGDCDNYAT--LKGHSGAVMELHYNTDGSM----- 123
Query: 280 VDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDG 339
L SA+T K V V+ ET L +G S NS L G DG
Sbjct: 124 ------LFSASTDKTVAVWDSETGERVKRL-KGHTSFVNSCYPAR--RGPQLVCTGSDDG 174
Query: 340 TLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGH 399
T+ ++D+ + Q+ ++ + + + + + +D +++WD R +L RGH
Sbjct: 175 TVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234
Query: 400 TAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
+ +LS + S +++ + D+ +V+ V+
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 48.5 bits (114), Expect = 1e-05
Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 10/109 (9%)
Query: 103 TNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQ 162
T+ ++GG D+ VW L +L + GH DSVT S + + + + M ++VW
Sbjct: 204 TSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
Query: 163 V---DTKEEVWSFEAGDLEWME-------WHPRAPVLLAGTADGNTWMW 201
V KE G++ E W P + AG+AD ++W
Sbjct: 264 VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 68.2 bits (165), Expect = 1e-11
Identities = 84/389 (21%), Positives = 152/389 (39%), Gaps = 43/389 (11%)
Query: 49 DVDFEEEEEEEGNEEGWVLE--PQEGVVGSME------GPDDSEVTFA-LHSASVFCVSL 99
+V ++E+EE NEEG + P++ +GS P + + L + +
Sbjct: 383 EVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIM 442
Query: 100 DPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLK 159
+ K T V G D + + +T + DS+L+A G ++
Sbjct: 443 NMKETTKRVRLGPDCLPSI-------CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVR 495
Query: 160 VWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPAT 219
VW V K+ +A DL ++ + +L D T + K G + P
Sbjct: 496 VWSVTPKKLRSVKQASDLSLID--KESDDVLERIMDEKT------ASELKILYGHSGPVY 547
Query: 220 CGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGS 279
PD + EDGT+R+W L+ + L G +GH P+ + G ++G
Sbjct: 548 GASFSPDRNYLLSSSEDGTVRLWSLQTFT---CLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
Query: 280 VDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDG 339
D A+L + + + +F G ++ N F A G D
Sbjct: 605 HDRVARLWATDHYQPLRIFA------------GHLADVNCTR---FHPNSNYVATGSADR 649
Query: 340 TLAIYDLAT-QTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRG 398
T+ ++D+ +R H+ I L + + T + DG V LWD G ++ + +G
Sbjct: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 709
Query: 399 HTAEILDFALSKDASLVVTTSGDHKAKVF 427
HT + S+D ++ + S D+ +++
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 59.7 bits (143), Expect = 5e-09
Identities = 53/223 (23%), Positives = 85/223 (38%), Gaps = 15/223 (6%)
Query: 24 DEEIIEVVELDPGPPDPDDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDS 83
DE+ +++ G P A D ++ E+G W L+ +VG
Sbjct: 529 DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVG-------- 580
Query: 84 EVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFS 143
+ H+ V+ P V+GG D A +W + L AGH V C F
Sbjct: 581 ---YKGHNYPVWDTQFSPY-GYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFH 636
Query: 144 HDSTLVATGDMSGLLKVWQV--DTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMW 201
+S VATG +++W V +++ G + + + P L G DG +W
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Query: 202 KVPNGDCKTFQGPNCPATCG-RVLPDGKRAVVGYEDGTIRIWD 243
+ +G + C R DG+ G D T+R+WD
Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 48.1 bits (113), Expect = 2e-05
Identities = 31/111 (27%), Positives = 47/111 (42%), Gaps = 7/111 (6%)
Query: 87 FALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDS 146
F H + ++ P LA TG D + +W + G ++ E GH D+V FS D
Sbjct: 665 FTGHKGPIHSLTFSPNGRFLA-TGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDG 723
Query: 147 TLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAP----VLLAGT 193
++A+G M +++W D + E D H P LL GT
Sbjct: 724 EILASGSMDNTVRLW--DAIKAFEDLETDDFTTATGHINLPENSQELLLGT 772
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/288 (24%), Positives = 121/288 (42%), Gaps = 35/288 (12%)
Query: 108 VTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKE 167
+T G D +W G LL +GH V A S D++ + +G + +W V + +
Sbjct: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQ 100
Query: 168 EVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLP 225
V F AG + ++++ A V+L+G+ D + W DC++ + P T
Sbjct: 101 VVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW-----DCRS-RRPEPVQTLDEAR- 153
Query: 226 DGKRAV--------VGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILT 277
DG +V G DG +R +DL+ G G+ P+TC ++DG L
Sbjct: 154 DGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGS-----PITCTCFSRDGQCTLV 208
Query: 278 GSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYL 337
S+D +L+ TG+++G ++ + +E + + S V+ +
Sbjct: 209 SSLDSTLRLLDKDTGELLGEYKGH---------KNQEYKLDCCLSERDTHVVSCSE---- 255
Query: 338 DGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLW 385
DG + +DL L SG+VQ L T ++ G V+ W
Sbjct: 256 DGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSVQCW 303
Score = 57.4 bits (137), Expect = 3e-08
Identities = 55/200 (27%), Positives = 82/200 (41%), Gaps = 21/200 (10%)
Query: 226 DGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAK 285
D G D + +WD+ G V++ GH G + V N++ ++IL+GS+D +
Sbjct: 78 DNSSLCSGGGDKAVVLWDVASGQ---VVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIR 134
Query: 286 LVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYD 345
+ RPE V + +G S S + G +DG + YD
Sbjct: 135 CWDCRSR------RPEPVQTLDEARDGVSSVKVSDHEI---------LAGSVDGRVRRYD 179
Query: 346 LATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAE--I 403
L L S I + SLD +RL D TG LL +Y+GH +
Sbjct: 180 LRMGQLFSDYVG-SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
Query: 404 LDFALSKDASLVVTTSGDHK 423
LD LS+ + VV+ S D K
Sbjct: 239 LDCCLSERDTHVVSCSEDGK 258
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/184 (21%), Positives = 77/184 (41%), Gaps = 23/184 (12%)
Query: 104 NTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQV 163
N+ +GG D +W ++ G+++ + GH V F+ ++T++ +G + ++ W
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDC 138
Query: 164 ------------DTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTF 211
+ ++ V S + D E +LAG+ DG + + G +
Sbjct: 139 RSRRPEPVQTLDEARDGVSSVKVSDHE----------ILAGSVDGRVRRYDLRMGQLFS- 187
Query: 212 QGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQD 271
P TC DG+ +V D T+R+ D G + KG + + L C + +D
Sbjct: 188 DYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERD 247
Query: 272 GSLI 275
++
Sbjct: 248 THVV 251
Score = 39.7 bits (91), Expect = 0.005
Identities = 20/47 (42%), Positives = 26/47 (55%)
Query: 375 TCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGD 421
TC D ++LW+ G LL Y GH E+LD A S D S + + GD
Sbjct: 42 TCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGD 88
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 68.2 bits (165), Expect = 1e-11
Identities = 70/288 (24%), Positives = 121/288 (42%), Gaps = 35/288 (12%)
Query: 108 VTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKE 167
+T G D +W G LL +GH V A S D++ + +G + +W V + +
Sbjct: 41 LTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQ 100
Query: 168 EVWSFE--AGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPNCPATCGRVLP 225
V F AG + ++++ A V+L+G+ D + W DC++ + P T
Sbjct: 101 VVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCW-----DCRS-RRPEPVQTLDEAR- 153
Query: 226 DGKRAV--------VGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILT 277
DG +V G DG +R +DL+ G G+ P+TC ++DG L
Sbjct: 154 DGVSSVKVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGS-----PITCTCFSRDGQCTLV 208
Query: 278 GSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYL 337
S+D +L+ TG+++G ++ + +E + + S V+ +
Sbjct: 209 SSLDSTLRLLDKDTGELLGEYKGH---------KNQEYKLDCCLSERDTHVVSCSE---- 255
Query: 338 DGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLW 385
DG + +DL L SG+VQ L T ++ G V+ W
Sbjct: 256 DGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAMGGSVQCW 303
Score = 57.4 bits (137), Expect = 3e-08
Identities = 55/200 (27%), Positives = 82/200 (41%), Gaps = 21/200 (10%)
Query: 226 DGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAK 285
D G D + +WD+ G V++ GH G + V N++ ++IL+GS+D +
Sbjct: 78 DNSSLCSGGGDKAVVLWDVASGQ---VVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIR 134
Query: 286 LVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYD 345
+ RPE V + +G S S + G +DG + YD
Sbjct: 135 CWDCRSR------RPEPVQTLDEARDGVSSVKVSDHEI---------LAGSVDGRVRRYD 179
Query: 346 LATQTLRHQCQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAE--I 403
L L S I + SLD +RL D TG LL +Y+GH +
Sbjct: 180 LRMGQLFSDYVG-SPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
Query: 404 LDFALSKDASLVVTTSGDHK 423
LD LS+ + VV+ S D K
Sbjct: 239 LDCCLSERDTHVVSCSEDGK 258
Score = 55.5 bits (132), Expect = 1e-07
Identities = 39/184 (21%), Positives = 77/184 (41%), Gaps = 23/184 (12%)
Query: 104 NTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGLLKVWQV 163
N+ +GG D +W ++ G+++ + GH V F+ ++T++ +G + ++ W
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDC 138
Query: 164 ------------DTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTF 211
+ ++ V S + D E +LAG+ DG + + G +
Sbjct: 139 RSRRPEPVQTLDEARDGVSSVKVSDHE----------ILAGSVDGRVRRYDLRMGQLFS- 187
Query: 212 QGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQD 271
P TC DG+ +V D T+R+ D G + KG + + L C + +D
Sbjct: 188 DYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERD 247
Query: 272 GSLI 275
++
Sbjct: 248 THVV 251
Score = 39.7 bits (91), Expect = 0.005
Identities = 20/47 (42%), Positives = 26/47 (55%)
Query: 375 TCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGD 421
TC D ++LW+ G LL Y GH E+LD A S D S + + GD
Sbjct: 42 TCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGD 88
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 65.9 bits (159), Expect = 7e-11
Identities = 55/217 (25%), Positives = 98/217 (45%), Gaps = 12/217 (5%)
Query: 89 LHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE----LLFECAGHKDSVTCAGFSH 144
L S+ V + P N +A GG D+ ++ L E + E GH ++C F
Sbjct: 95 LRSSWVMTCAYAPSGNYVAC-GGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLD 153
Query: 145 DSTLV-ATGDMSGLLKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMW 201
DS +V ++GD + L W ++T ++ +F +GD+ + P ++G D ++ +W
Sbjct: 154 DSQIVTSSGDTTCAL--WDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLW 211
Query: 202 KVPNGDCK-TFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEGHQ 260
+ +G C+ +F G P+G G +D T R++DL+ + +L +
Sbjct: 212 DIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL-LLYSHDNII 270
Query: 261 GPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGV 297
+T VA ++ G L+L G D + G GV
Sbjct: 271 CGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGV 307
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/163 (25%), Positives = 65/163 (39%), Gaps = 6/163 (3%)
Query: 86 TFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHD 145
TF HS V +SL P T V+G D + +W + DG GH + F +
Sbjct: 179 TFTGHSGDVMSLSLSPDMRTF-VSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPN 237
Query: 146 STLVATGDMSGLLKVWQVDTKEEVWSFEAGDL----EWMEWHPRAPVLLAGTADGNTWMW 201
ATG +++ + +E+ + ++ + + +LLAG D N +W
Sbjct: 238 GYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVW 297
Query: 202 KVPNGD-CKTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 243
GD G + +C V DG G D +RIW+
Sbjct: 298 DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 41.6 bits (96), Expect = 0.001
Identities = 38/169 (22%), Positives = 69/169 (40%), Gaps = 29/169 (17%)
Query: 266 VAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGF 325
V+A+QDG LI+ S TT K+ + S+ V + +
Sbjct: 71 VSASQDGKLIIWDSY---------TTNKMHAI----------------PLRSSWVMTCAY 105
Query: 326 CSVMPLAAVGYLDGTLAIYDLATQT----LRHQCQHQSGIVQLLWEAGTAVVYTCSLDGI 381
A G LD +IY+L T+ + + +G + + + T S D
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT 165
Query: 382 VRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQ 430
LWD T + T + GH+ +++ +LS D V+ + D +K++ ++
Sbjct: 166 CALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIR 214
Score = 40.0 bits (92), Expect = 0.004
Identities = 60/307 (19%), Positives = 105/307 (34%), Gaps = 31/307 (10%)
Query: 132 GHKDSVTCAGFSHDSTLVATGDMSGLLKVWQVDTKEEVWSFEAGDLEWM---EWHPRAPV 188
GH + + +DS L+ + G L +W T ++ + W+ + P
Sbjct: 53 GHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRS-SWVMTCAYAPSGNY 111
Query: 189 LLAGTADG--NTWMWKVPNGDCKT---FQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWD 243
+ G D + + K G+ + G +C R L D + V D T +WD
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFL-DDSQIVTSSGDTTCALWD 170
Query: 244 LKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETV 303
++ GH G + ++ + D ++G+ D +KL G F
Sbjct: 171 IETAQQTTTF---TGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF----- 222
Query: 304 ASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQS---G 360
G S+ N+V F A G D T ++DL H + G
Sbjct: 223 -------TGHVSDINAV---SFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICG 272
Query: 361 IVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSG 420
I + + ++ D +WD G GH + ++ D V T S
Sbjct: 273 ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332
Query: 421 DHKAKVF 427
D +++
Sbjct: 333 DSFLRIW 339
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 65.9 bits (159), Expect = 7e-11
Identities = 57/252 (22%), Positives = 102/252 (40%), Gaps = 22/252 (8%)
Query: 38 PDPDDLAQEMEDVDFEEEEEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCV 97
PD + +D + E G + + ++G G G HS+ V C+
Sbjct: 156 PDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG----------HSSHVLCM 205
Query: 98 SLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAGHKDSVTCAGFSHDSTLVATGDMSGL 157
++ LA +G +W + L+ GH+D+V+ F + + +
Sbjct: 206 AISSDGKYLA-SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRS 264
Query: 158 LKVWQVDTKEEVWSF--EAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDCKTFQGPN 215
+KVW V V + + ++ R + AG DG +WK+P F G
Sbjct: 265 VKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQ 324
Query: 216 CPATCGRVLPDGKRAVVGYEDGTIRIWDLKQGSPI------HVLKGTEGHQGP--LTCVA 267
C ++ + + V G +DG++ +W L + P+ H L+G G + P ++ VA
Sbjct: 325 GSIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVA 383
Query: 268 ANQDGSLILTGS 279
A + L+ TGS
Sbjct: 384 ALLNTDLVATGS 395
Score = 38.9 bits (89), Expect = 0.009
Identities = 43/170 (25%), Positives = 70/170 (41%), Gaps = 18/170 (10%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESE- 316
GHQ +TC+ D S I + + DC S +G+ + V P +G E +
Sbjct: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVI--------PRAKKGAEGKP 195
Query: 317 ---SNSVESLGFCSVMPLAAVGYLDGTLAIYDL-ATQTLRHQCQHQSGIVQLLWEAGTAV 372
S+ V + S A G + I++ + Q L H+ + L + GT
Sbjct: 196 PGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQ 255
Query: 373 VYTCSLDGIVRLWDARTGRLLTDYRGHTAEI--LDFALSKDASLVVTTSG 420
+Y+ S D V++W+ + GH + LD ALS++ VT G
Sbjct: 256 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALD-ALSREC--CVTAGG 302
Score = 34.3 bits (77), Expect = 0.23
Identities = 26/104 (25%), Positives = 48/104 (46%), Gaps = 13/104 (12%)
Query: 70 QEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLF- 128
++G V + P++S++ F H S+ C+ L + + V+G +D +W LS L
Sbjct: 303 RDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHM--VSGADDGSVALWGLSKKRPLAL 360
Query: 129 --ECAGHKDS--------VTCAGFSHDSTLVATGDMSGLLKVWQ 162
E G + ++ ++ LVATG S +++WQ
Sbjct: 361 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 404
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 65.9 bits (159), Expect = 7e-11
Identities = 83/388 (21%), Positives = 142/388 (36%), Gaps = 68/388 (17%)
Query: 56 EEEEGNEEGWVLEPQEGVVGSMEGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDK 115
EE +E +P E + G +E P + H + VF + +P ++ LA +G D
Sbjct: 145 EENGAHEINNHSKPME-IDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLA-SGSGDST 202
Query: 116 AFVWRLSDGE-------LLFEC---AGH----KDSVTCAGFSHDSTLVATGDMSGLLKVW 161
A +W L++ +L C GH VT ++ D TL+A G G ++W
Sbjct: 203 ARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIW 262
Query: 162 -QVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNTWMWKVPNGDC------------ 208
+ G + ++W+ + +L+ D T +W G+
Sbjct: 263 TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPAL 322
Query: 209 ------------------------------KTFQGPNCPATCGRVLPDGKRAVVGYEDGT 238
KTFQG + P G +D T
Sbjct: 323 DVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMT 382
Query: 239 IRIWDLKQGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVF 298
++IW +KQ + +H L + H + + + G T + + L SA+ V ++
Sbjct: 383 LKIWSMKQDACVHDL---QAHSKEIYTIKWSPTGP--ATSNPNSSIMLASASFDSTVRLW 437
Query: 299 RPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQ 358
E +L + +E V S+ F A G D + I++ + +L H Q
Sbjct: 438 DVEQGVCTHTLMKHQE----PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGT 493
Query: 359 SGIVQLLWEAGTAVVYTCSLDGIVRLWD 386
GI ++ W A V + DG V + D
Sbjct: 494 GGIFEVCWNARGDKVGASASDGSVCVLD 521
Score = 49.3 bits (116), Expect = 7e-06
Identities = 66/304 (21%), Positives = 106/304 (34%), Gaps = 63/304 (20%)
Query: 182 WHPRAPVLLAGTADGNTWMWKV---PNGDCKTFQGPNCPATCGRVLP------------D 226
W+P + +L +G+ D +W + NG +C G +P D
Sbjct: 187 WNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSD 246
Query: 227 GKRAVVGYEDGTIRIWDLKQGSPIHVLKGTEG-HQGPLTCVAANQDGSLILTGSVDCQAK 285
G +G DG RIW + G+ L T G H+GP+ + N+ G+ +L+ VD
Sbjct: 247 GTLLAMGSYDGFARIWT-ENGN----LASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTI 301
Query: 286 LVSATTGKVVGVFRPETVASQPSLG-----------------------------EGEESE 316
+ A TG+ F S P+L + +
Sbjct: 302 IWDAHTGEAKQQF---PFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGH 358
Query: 317 SNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEA------- 368
+N V ++ + L A D TL I+ + H Q H I + W
Sbjct: 359 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSN 418
Query: 369 --GTAVVYTCSLDGIVRLWDARTGRLLTDYRGHTAEILDFALSKDASLVVTTSGDHKAKV 426
+ ++ + S D VRLWD G H + A S D + + S D +
Sbjct: 419 PNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHI 478
Query: 427 FCVQ 430
+ Q
Sbjct: 479 WNTQ 482
Score = 44.7 bits (104), Expect = 2e-04
Identities = 48/181 (26%), Positives = 68/181 (37%), Gaps = 13/181 (7%)
Query: 258 GHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVASQPSLGEGEESES 317
GH+ + A N L+ +GS D A++ + G + V G + S
Sbjct: 177 GHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG--STQLVLRHCIREGGHDVPS 234
Query: 318 NS-VESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQLLWEAGTAVVYTC 376
N V SL + S L A+G DG I+ QH+ I L W V +
Sbjct: 235 NKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 377 SLDGIVRLWDARTGRLLTDYRGHTAEILDF---------ALSKDASLVVTTSG-DHKAKV 426
+D +WDA TG + H+A LD + S D + V G DH K
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKT 354
Query: 427 F 427
F
Sbjct: 355 F 355
Score = 37.4 bits (85), Expect = 0.027
Identities = 50/217 (23%), Positives = 85/217 (39%), Gaps = 41/217 (18%)
Query: 233 GYEDGTIRIWDLKQ----GSPIHVLKGT---EGHQGP----LTCVAANQDGSLILTGSVD 281
G D T RIW+L + GS VL+ GH P +T + N DG+L+ GS D
Sbjct: 197 GSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYD 256
Query: 282 CQAKL------VSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVG 335
A++ +++T G+ G P + N V S G
Sbjct: 257 GFARIWTENGNLASTLGQHKG----------PIFALKWNKKGNYVLSAG----------- 295
Query: 336 YLDGTLAIYDLATQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLT 394
+D T I+D T + Q H + + + W+ +CS D + + +
Sbjct: 296 -VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFA-SCSTDMCIHVCRLGCDHPVK 353
Query: 395 DYRGHTAEILDFALSKDASLVVTTSGDHKAKVFCVQR 431
++GHT E+ L+ + S D K++ +++
Sbjct: 354 TFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQ 390
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,382,212
Number of Sequences: 37866
Number of extensions: 984020
Number of successful extensions: 8458
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 271
Number of HSP's successfully gapped in prelim test: 181
Number of HSP's that attempted gapping in prelim test: 4753
Number of HSP's gapped (non-prelim): 2302
length of query: 434
length of database: 18,247,518
effective HSP length: 105
effective length of query: 329
effective length of database: 14,271,588
effective search space: 4695352452
effective search space used: 4695352452
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.