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Search of human proteins with 55741677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55741677 SET domain containing 1A [Homo sapiens]
(1707 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55741677 SET domain containing 1A [Homo sapiens] 3458 0.0
gi|210032580 SET domain containing 1B [Homo sapiens] 1035 0.0
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 156 2e-37
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [... 150 8e-36
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 129 2e-29
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s... 129 2e-29
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 105 4e-22
gi|209862789 microtubule associated monoxygenase, calponin and L... 104 8e-22
gi|153792074 proline rich 12 [Homo sapiens] 102 3e-21
gi|110349719 titin isoform N2-A [Homo sapiens] 100 2e-20
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens] 97 1e-19
gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens] 97 1e-19
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens] 97 1e-19
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 97 2e-19
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 91 7e-18
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ... 91 1e-17
gi|149773456 hypothetical protein LOC643314 [Homo sapiens] 91 1e-17
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 90 2e-17
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 89 4e-17
gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 88 8e-17
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 86 2e-16
gi|197313748 SET domain containing 2 [Homo sapiens] 86 3e-16
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 85 7e-16
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens] 84 1e-15
gi|27477095 nuclear receptor binding SET domain protein 1 isofor... 84 1e-15
gi|19923586 nuclear receptor binding SET domain protein 1 isofor... 84 1e-15
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 83 2e-15
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 83 2e-15
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 82 3e-15
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform... 82 3e-15
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 3458 bits (8966), Expect = 0.0
Identities = 1707/1707 (100%), Positives = 1707/1707 (100%)
Query: 1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDL 60
MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDL
Sbjct: 1 MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDL 60
Query: 61 QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV 120
QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV
Sbjct: 61 QDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEV 120
Query: 121 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY 180
EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY
Sbjct: 121 EEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY 180
Query: 181 ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNG 240
ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNG
Sbjct: 181 ELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNG 240
Query: 241 TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR 300
TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR
Sbjct: 241 TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRR 300
Query: 301 SENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFR 360
SENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFR
Sbjct: 301 SENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFR 360
Query: 361 SSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRP 420
SSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRP
Sbjct: 361 SSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRP 420
Query: 421 TDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV 480
TDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV
Sbjct: 421 TDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV 480
Query: 481 PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT 540
PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT
Sbjct: 481 PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT 540
Query: 541 PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP 600
PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP
Sbjct: 541 PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP 600
Query: 601 PQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFV 660
PQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFV
Sbjct: 601 PQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFV 660
Query: 661 NSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPP 720
NSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPP
Sbjct: 661 NSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPP 720
Query: 721 PQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELA 780
PQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELA
Sbjct: 721 PQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELA 780
Query: 781 EGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNA 840
EGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNA
Sbjct: 781 EGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNA 840
Query: 841 AKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEP 900
AKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEP
Sbjct: 841 AKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEP 900
Query: 901 SEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFA 960
SEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFA
Sbjct: 901 SEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFA 960
Query: 961 LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020
LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY
Sbjct: 961 LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020
Query: 1021 ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP 1080
ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP
Sbjct: 1021 ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP 1080
Query: 1081 PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGP 1140
PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGP
Sbjct: 1081 PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGP 1140
Query: 1141 PAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP 1200
PAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP
Sbjct: 1141 PAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP 1200
Query: 1201 RGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLA 1260
RGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLA
Sbjct: 1201 RGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLA 1260
Query: 1261 LTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEP 1320
LTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEP
Sbjct: 1261 LTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEP 1320
Query: 1321 VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS 1380
VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS
Sbjct: 1321 VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS 1380
Query: 1381 SSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDM 1440
SSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDM
Sbjct: 1381 SSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDM 1440
Query: 1441 SYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEGYY 1500
SYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEGYY
Sbjct: 1441 SYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEGYY 1500
Query: 1501 PISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKL 1560
PISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKL
Sbjct: 1501 PISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLLKL 1560
Query: 1561 NQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIG 1620
NQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIG
Sbjct: 1561 NQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIG 1620
Query: 1621 SSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEI 1680
SSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEI
Sbjct: 1621 SSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEI 1680
Query: 1681 TYDYKFPLEDNKIPCLCGTESCRGSLN 1707
TYDYKFPLEDNKIPCLCGTESCRGSLN
Sbjct: 1681 TYDYKFPLEDNKIPCLCGTESCRGSLN 1707
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 1035 bits (2675), Expect = 0.0
Identities = 756/2018 (37%), Positives = 975/2018 (48%), Gaps = 430/2018 (21%)
Query: 7 GDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRC- 65
G + + WR+YKL++DPAL ++ K+YRYDG HFS+ S PVE ++DPR
Sbjct: 19 GPSGERRNHHWRSYKLMIDPAL----KKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVV 74
Query: 66 HVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEI 125
+ +KN++ L VPKFK+DEFY+G +P K+VTFA+LNDN+RE FL+DMC+KYGEVEEVEI
Sbjct: 75 GIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNIRENFLRDMCKKYGEVEEVEI 134
Query: 126 LLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSVMGNIIHAQLDIKGQQRMKYYELIVN 185
L +P+T+KHLG+A+V+F + RGAK+ V++LH TSVMGNIIH +LD KG+ RM++YEL+V
Sbjct: 135 LYNPKTKKHLGIAKVVFATVRGAKDAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVT 194
Query: 186 GSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQ 245
G YTPQT+P G A R + +A +G+++V GTP SQ
Sbjct: 195 GRYTPQTLPVGELDAVSPIVNETLQLSDALKRLKDGGLSAGCGSGSSSVTPNSGGTPFSQ 254
Query: 246 DTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTS---------- 295
DT++SS R DTP+S+GQ GTP T R TP+SQDS+YSS + S
Sbjct: 255 DTAYSSCRLDTPNSYGQ-------GTPLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPAVT 307
Query: 296 FKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSS 355
FK RR E+ + DA++RRH ++ A TA+A ATA+ SS + + SS
Sbjct: 308 FKARRHESKFTDAYNRRHEHHYVHNSPAVTAVAG---ATAAFRGSSDLPFGAVGGTGGSS 364
Query: 356 SSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYT--SYL 413
F++ + + HT PP +AT PG A F P T ++
Sbjct: 365 GPPFKAQPQDSATF--------AHTP-PPAQAT--PAPGFKSA------FSPYQTPVAHF 407
Query: 414 PPEPSRPT---------DQDYRPPASEAPPPEPP-EPGG----GGGGGGPSPEREEVRTS 459
PP P PT ++R + APPP PP EP G G P P+ +
Sbjct: 408 PPPPEEPTATAAFGARDSGEFR--RAPAPPPLPPAEPLAKEKPGTPPGPPPPDTNSMELG 465
Query: 460 PRPA---SPARSGSPAPETTNESV--PFAQHSSLDSRIEMLLKEQRSKFSFLA---SDTE 511
RP SP SP T S P H SLDSRIEMLLKEQR+K FL SDTE
Sbjct: 466 GRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLLFLREPDSDTE 525
Query: 512 EEEENSSMVLGARDTGSEVPSGSGHGPC----TPP---PAPANFEDVAPT---------- 554
+ E S + + P G+ P TPP P+ ED++PT
Sbjct: 526 LQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSSTGLEDISPTPLPDSDEDEE 585
Query: 555 ---GSG-----EPGA---------TRE---------SPKANGQNQASPCSSGDDMEISDD 588
G G EPG T E +P + ++ SSG+DMEISDD
Sbjct: 586 LDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQ-SSGEDMEISDD 644
Query: 589 DRGGSP-------------------------------PPAPTPPQQPPPPPPPPPPP--- 614
+ +P PP P P PPPPPPPPP P
Sbjct: 645 EMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPPPGFPPLPPPPPPPPPQPGFP 704
Query: 615 -PPYLASLPLGYPPHQPAYLLPPRP-----DGPPPPEYPPPPPPPPHIYDFVNSLELMDR 668
PP L P PP PA +PP P PPPP PP PP PP ++ V +++
Sbjct: 705 MPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFP-VMQVDMSHV 763
Query: 669 LGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIA----ASAGPPGGAFGEAFLPFPPPQEA 724
LG QWGGMPMSFQMQTQ+L+RL G+G +A + G F+ PP
Sbjct: 764 LGGQWGGMPMSFQMQTQVLSRL---MTGQGACPYPPFMAAAAAAASAGLQFVNLPP---- 816
Query: 725 AYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKT 784
Y P++L G GRG H P PLP S PR+E
Sbjct: 817 -YRGPFSLSNSGP-GRGQ------HWP------PLPKFDPSVPPPGYMPRQED------- 855
Query: 785 LPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQ- 843
P TV VL ++++E+K+IM+RDLNRKMVE VAF AFD+WW+ KE AK K
Sbjct: 856 -PHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSG 914
Query: 844 QAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEI 903
+ K+ED+ K K + L L W K G G E G GLRGA+RLPSFKVKRKEP +
Sbjct: 915 EHKDEDRPKPKDRIASCL-LESWGKGEGL-GYEGLGLGIGLRGAIRLPSFKVKRKEPPDT 972
Query: 904 SEASEEKRPRPSTPAEEDEDDPEQEKEAG--------------------EPGRPGTKPPK 943
+ + ++KR RPST +E++++ E+E++ P RP
Sbjct: 973 TSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSG 1032
Query: 944 RDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDD-----------------EEDEE 986
+E+ ++ + ++S + E EE +E + D+ DD E+DE
Sbjct: 1033 GEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEG 1092
Query: 987 DEDREEAVDTTKKETEV--------------------SDGEDEES-------DSSSKCSL 1019
D D EE V + E S EDEE + + +
Sbjct: 1093 DSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEM 1152
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERP-------- 1071
A+ + D E ++ + + + S + +E EERP
Sbjct: 1153 VAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPL 1212
Query: 1072 -----------------------AALPSASPPPREV----------------------PV 1086
A L S PP +EV P+
Sbjct: 1213 PVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPM 1272
Query: 1087 PTPAPVEVPVPERVAGSPVTPLPEQEAS----PARPAGP-TEESPPSAP----------- 1130
P P++ P+P P +P PE E + P+ P P E+ PP P
Sbjct: 1273 MLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQS 1332
Query: 1131 ----------------------LRPPEPPAGP---PAPAPRPDE---------------- 1149
L P+ P P PAP+P
Sbjct: 1333 TETVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPT 1392
Query: 1150 --RPSSPI--PLLPPPKKRRKTVSFSAIEVV------PAPEPPPATPPQAKFPGPASRKA 1199
PS P+ P+ P P RR S V P P P P P A PA +A
Sbjct: 1393 FSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLAL---PAVLRA 1449
Query: 1200 PRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADL 1259
+ PL A L P + GR R L+ + A+ +L
Sbjct: 1450 QARAPTPLP--PLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVR-PPAGAALGREL 1506
Query: 1260 ALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPE 1319
L P + P P+ D PR + L+ A P PP P PP
Sbjct: 1507 LLLPGQPQTPVFPSTHD------------PRT----VTLDFRNAGIPAPPPPLPPQPPPP 1550
Query: 1320 PVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDS 1379
P P P P E+ +EA P P+ G +E EE E + S
Sbjct: 1551 PPPPPVEPTKLPFKEL---DNQWPSEAIPPGPR------------GRDEVTEEYMELAKS 1595
Query: 1380 SSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRA-YEPRSEFEQMTILYDIWNSGLDSE 1438
G RR + H P P PP+ + PRSEFE+MTILYDIWN G+D E
Sbjct: 1596 ------RGPWRRPPKKRHEDLVPPAGSPELSPPQPLFRPRSEFEEMTILYDIWNGGIDEE 1649
Query: 1439 DMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSARSEG 1498
D+ +L +TYERLLQQ +G DWLNDT WV+H T+L++ K+K+R DG REH TG ARSEG
Sbjct: 1650 DIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKR-DDGIREHVTGCARSEG 1708
Query: 1499 YYPISKKEKDKYLDVCPVSARQLEGVDTQG---------TNRVLSERRSEQRRLLSAIGT 1549
+Y I KK+K +YL+ S + DTQG + R SERRSEQRRLLS+
Sbjct: 1709 FYTIDKKDKLRYLNSSRASTDE-PPADTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTG 1767
Query: 1550 SAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADM 1609
S DSDLLK NQLKFRKKKL+F +S IH+WGLFAMEPIAADEMVIEYVGQNIRQ++ADM
Sbjct: 1768 SC--DSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADM 1825
Query: 1610 REKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIY 1669
REKRY EGIGSSY+FRVDHDTIIDATKCGN ARFINH C PNCYAKVIT+ESQKKIVIY
Sbjct: 1826 REKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIY 1885
Query: 1670 SKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN 1707
SKQ I V+EEITYDYKFP+ED KIPCLCG+E+CRG+LN
Sbjct: 1886 SKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN 1923
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 156 bits (394), Expect = 2e-37
Identities = 181/650 (27%), Positives = 245/650 (37%), Gaps = 135/650 (20%)
Query: 1080 PPREVPVPTPAPV-------EVPVPERVAGSPVTPLPEQEASPAR--PAGPTEESPPSAP 1130
P E P P + + +V V G PV P +Q P P PT + P P
Sbjct: 2179 PAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTSWTLPPGP 2238
Query: 1131 LRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAK 1190
L P G PAP P P + + P R+ + + PPA PP
Sbjct: 2239 LLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTFSG-RSPPAPPPY-- 2295
Query: 1191 FPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTE 1250
KAPR LD G +E+ PG
Sbjct: 2296 -------KAPR----------LDED---------------------GEASEDTPQVPG-- 2315
Query: 1251 VDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTP 1310
L + R P + V D + E P PL P
Sbjct: 2316 -----LGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQER-----------SPLL 2359
Query: 1311 PAPALRPPEPVPAPAALFSSPADEVLEAP------EVVVAEAEEPKPQQLQQQREEGEEE 1364
P P PP+ VP P D +LE+ E +E E P P + Q +
Sbjct: 2360 PLPEDGPPQ-VP------DGPPDLLLESQWHHYSGEASSSEEEPPSPDDKENQAPK--RT 2410
Query: 1365 GEEEGEEEEEESSDSSSSSDGEGALRR-----RSLRSHARRRRPPPPPPPPPPRAYEPRS 1419
G E E S + EGA R + R HAR R ++ S
Sbjct: 2411 GPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRH----------LSFSGMS 2460
Query: 1420 EFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRK 1479
+ I +D L +Q GA + +H ++
Sbjct: 2461 GARLLGIHHD----------------AVIFLAEQLPGAQRCQHYKFRYH---------QQ 2495
Query: 1480 RRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSE 1539
Q+ P + G+AR+E Y + K D + + EG E E
Sbjct: 2496 GEGQEEPPLNPHGAARAEVY--LRKCTFDMFNFLASQHRVLPEGA-------TCDEEEDE 2546
Query: 1540 QRRLLSAIGTSAIMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVG 1599
+ + TS + + + K K+ + RS IH GLF I A EMVIEY G
Sbjct: 2547 VQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSG 2606
Query: 1600 QNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVIT 1659
IR ++ D REK Y +GIG Y+FR+D ++DAT GN ARFINH C PNC+++VI
Sbjct: 2607 IVIRSVLTDKREKFYDGKGIGC-YMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIH 2665
Query: 1660 IESQKKIVIYSKQPIGVDEEITYDYKFPLED--NKIPCLCGTESCRGSLN 1707
+E QK IVI++ + I EE+TYDYKFP+ED NK+PC CG + CR LN
Sbjct: 2666 VEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2715
Score = 81.3 bits (199), Expect = 8e-15
Identities = 87/312 (27%), Positives = 117/312 (37%), Gaps = 51/312 (16%)
Query: 1059 ESSSEDEEEEERPAA---LPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
E E EE+EER A +P+A ++P P P+ P P SP PLP SP
Sbjct: 373 EKDKEGEEKEERAVAEEMMPAAEKEEAKLP---PPPLTPPAP-----SPPPPLPPPSTSP 424
Query: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLP---------PPKKRRK 1166
P P PP P+ PP P+ PP PA +E+ SP P++P PP +
Sbjct: 425 PPPLCP----PPPPPVSPPPLPSPPPPPA--QEEQEESPPPVVPATCSRKRGRPPLTPSQ 478
Query: 1167 TVSFSAIEVVPAPEPPPATPPQAKFPGP---ASRKAPRGVE--RTIRNLPLDHASLVKSW 1221
A P PP P GP + AP+ + IR +
Sbjct: 479 RAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIM--------- 529
Query: 1222 PEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPA-VEDSEAT 1280
P +R R R + E+ P EV + + +P +P PA V
Sbjct: 530 PVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPP---VPQEPAPVPSPPRA 586
Query: 1281 ETSDEAERPRPLLSHILLEH------NYALAVKPTPPAPALRPPEPVPAPAALFSSPADE 1334
T P P +L + + P PPAP PP P P PA SS
Sbjct: 587 PTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPP-PPPAPSPPPAPATSSRRPL 645
Query: 1335 VLEAPEVVVAEA 1346
+L AP+ +EA
Sbjct: 646 LLRAPQFTPSEA 657
Score = 68.9 bits (167), Expect = 4e-11
Identities = 89/361 (24%), Positives = 112/361 (31%), Gaps = 80/361 (22%)
Query: 346 SSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEP-----PGAPFAEN 400
S + SS S RS P R + T PP R P P E
Sbjct: 128 SDEDVAPSSLRSALRSQRGRAP---RGRGRKHKTTPLPPPRLADVAPTPPKTPARKRGEE 184
Query: 401 TAERFPPSYTSYLPP------------EPSRPTDQDYRPPASEA---------------- 432
ER + T L EPS P RPP A
Sbjct: 185 GTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAA 244
Query: 433 ---PPPEPPEP--------GGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVP 481
P PEPP P G GP P R + + R G +P
Sbjct: 245 VTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGR--GGGLP 302
Query: 482 FAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSE-VPSGSGHGPCT 540
F I+ + + ++ K L+ E + +D V SG G PC
Sbjct: 303 FV--------IKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCW 354
Query: 541 PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP 600
++ E E G+ + + + M ++ + PPP TP
Sbjct: 355 KK------QEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTP 408
Query: 601 PQQPPPPPPPPP---PPPPYLASLPLGYPPHQPAYLLPPRPDGPPPP------EYPPPPP 651
P PPPP PPP PPPP PP P PP P PPPP E PPP
Sbjct: 409 PAPSPPPPLPPPSTSPPPPLC-------PPPPPPVSPPPLPSPPPPPAQEEQEESPPPVV 461
Query: 652 P 652
P
Sbjct: 462 P 462
Score = 67.0 bits (162), Expect = 1e-10
Identities = 106/385 (27%), Positives = 139/385 (36%), Gaps = 73/385 (18%)
Query: 1043 SSSSSSSSSSSSSSSSESSSEDEEEEERPAALP--SASPPPREVPVPTPAPVEVPVPERV 1100
S+ SS + E + + E P P + SPP + P P P+P P P
Sbjct: 533 SARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPAPVPSPPRAPTPP-- 590
Query: 1101 AGSPVTPLPEQEASPARP-----AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPI 1155
S PLPE+ S R T E PP PP PP PPAP+P P SS
Sbjct: 591 --STPVPLPEKRRSILREPTFRWTSLTRELPPP----PPAPPP-PPAPSPPPAPATSSRR 643
Query: 1156 PLLP-----PPKKRRKTVSFSAIEVVP--APEPPPATPPQAKFPGPASRKAPRGVERTIR 1208
PLL P + + S + P APE P PP A PA + PR V RT
Sbjct: 644 PLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPAD-DSPAEPE-PRAVGRT-N 700
Query: 1209 NLPLDHASLVKSWP--EEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARR 1266
+L L + V + P EVS G + A G T+ + +P + +L AL P
Sbjct: 701 HLSLPRFAPVVTTPVKAEVSPHG-APALSNGPQTQAQLLQPLQALQTQLLPQ-ALPP--- 755
Query: 1267 GLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAA 1326
P+P L PP+P PP A
Sbjct: 756 ----------------------PQPQLQ--------------PPPSPQQMPPLEKARIAG 779
Query: 1327 LFSSPADEVLEAPEVVVAEAEEP--KPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSD 1384
+ S P V E ++ A+ K Q QQQ+ G+ EE + S
Sbjct: 780 VGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISD- 838
Query: 1385 GEGALRRRSLRSHARRRRPPPPPPP 1409
G +R A+R RP P P
Sbjct: 839 -RGPVRSEDESVEAKRERPSGPESP 862
Score = 65.5 bits (158), Expect = 4e-10
Identities = 83/305 (27%), Positives = 102/305 (33%), Gaps = 88/305 (28%)
Query: 386 RATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGG 445
RA EE P AE + PP + PP PS P PP++ PPP P P
Sbjct: 384 RAVAEEM--MPAAEKEEAKLPPPPLT--PPAPSPPPPLP--PPSTSPPPPLCPPP----- 432
Query: 446 GGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSF 505
P P SP SP P E Q S + +R +
Sbjct: 433 --------------PPPVSPPPLPSPPPPPAQEE----QEESPPPVVPATCSRKRGRPPL 474
Query: 506 LASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRES 565
S E E A G E G P TP P+ A TG + +
Sbjct: 475 TPSQRAERE--------AARAGPE-----GTSPPTPTPSTA-------TGGPPEDSPTVA 514
Query: 566 PKA-----NGQNQASPCSSGDDMEI-------SDDDRGGSP---------PP---APTPP 601
PK+ N + P S + D+D P PP +P P
Sbjct: 515 PKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVP 574
Query: 602 QQPPPPPPPPPPPPPYLASLPLGYPPHQPAYL-------------LPPRPDGPPPPEYPP 648
Q+P P P PP P P S P+ P + + L LPP P PPPP P
Sbjct: 575 QEPAPVPSPPRAPTP--PSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPS 632
Query: 649 PPPPP 653
PPP P
Sbjct: 633 PPPAP 637
Score = 63.9 bits (154), Expect = 1e-09
Identities = 89/385 (23%), Positives = 127/385 (32%), Gaps = 111/385 (28%)
Query: 1047 SSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVT 1106
S S E +DEEEE++ +E ER +
Sbjct: 346 SGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKE--------------ERAVAEEMM 391
Query: 1107 PLPEQEASPARPAGPTEESPPSAPLRP-PEPPAGPPAPAPRPDERPSSPIPLLPPPKKRR 1165
P E+E + P PP P P P PP PP+ +P P P P P+ PPP
Sbjct: 392 PAAEKEEAKLPP-------PPLTPPAPSPPPPLPPPSTSPPPPLCPPPPPPVSPPP---- 440
Query: 1166 KTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEV 1225
+P+P PPPA Q + P P P R PL P +
Sbjct: 441 ----------LPSPPPPPAQEEQEESPPPV---VPATCSRKRGRPPLT--------PSQR 479
Query: 1226 SRGGRSRAGGRGR---LTEEEEAEPGTEVDLAVLADLALT---PARRGLPALPAVEDSEA 1279
+ +RAG G A G D +A + T R+ + + + S
Sbjct: 480 AEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRV 539
Query: 1280 TET------SDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPAD 1333
+T D + P+ +S +L + +PP P + P PVP+P + P+
Sbjct: 540 IKTPRRFMDEDPPKPPKVEVSPVLRP-----PITTSPPVP--QEPAPVPSPPRAPTPPST 592
Query: 1334 EVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRS 1393
V P P++ + LR +
Sbjct: 593 PV-------------PLPEKRRS-------------------------------ILREPT 608
Query: 1394 LR-SHARRRRPPPPPPPPPPRAYEP 1417
R + R PPPPP PPPP A P
Sbjct: 609 FRWTSLTRELPPPPPAPPPPPAPSP 633
Score = 58.2 bits (139), Expect = 7e-08
Identities = 86/335 (25%), Positives = 104/335 (31%), Gaps = 95/335 (28%)
Query: 392 PPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSP 451
PP P A + PP TS PP P P PP +PPP P P P P
Sbjct: 404 PPLTPPAPSPPPPLPPPSTS--PPPPLCPP-----PPPPVSPPPLPSPP--------PPP 448
Query: 452 EREEVRTSPRPASP----------------------ARSG-------SPAPETTNESVPF 482
+EE SP P P AR+G +P P T P
Sbjct: 449 AQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPP- 507
Query: 483 AQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGA----RDTGSEVPSGSGHGP 538
++ + LK R + S SS V+ D P P
Sbjct: 508 EDSPTVAPKSTTFLKNIRQFIMPVVS------ARSSRVIKTPRRFMDEDPPKPPKVEVSP 561
Query: 539 CTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPA- 597
PP + P EP P+A P + + + R P
Sbjct: 562 VLRPPITTS-----PPVPQEPAPVPSPPRA-------PTPPSTPVPLPEKRRSILREPTF 609
Query: 598 ---------PTPPQQPPPPPPPPPPPPPYLAS---LPLGYPPHQPA--------YLLPPR 637
P PP PPPPP P PPP P +S L L P P+ +L P
Sbjct: 610 RWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPP 669
Query: 638 PDGPPPPEYPPPPP-------PPPHIYDFVNSLEL 665
P G P P PPP P P N L L
Sbjct: 670 PLGAPEAPEPEPPPADDSPAEPEPRAVGRTNHLSL 704
Score = 50.4 bits (119), Expect = 1e-05
Identities = 63/246 (25%), Positives = 92/246 (37%), Gaps = 34/246 (13%)
Query: 1069 ERPAALPSASPP--PREVPVPTPAP-------VEVP--VPER--VAGSPVTPLPEQEASP 1115
ER + + + PP P P PAP ++VP P R + G PLP SP
Sbjct: 1833 ERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLP----SP 1888
Query: 1116 ARPAGPTEESPPSAPLRPPEPPA-----GPPAPAPRPDERPSSPIP-----LLPPPKKRR 1165
P+ T P P PP P AP P P S P+ +PPP
Sbjct: 1889 GSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVV 1948
Query: 1166 KTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWP--E 1223
++ ++ E+ P P PP+ P + G+ + ASL+ + P E
Sbjct: 1949 TALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFA---ASLLGTEPFQE 2005
Query: 1224 EVSRGGR--SRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATE 1281
E+ G S GG G +EEE + + V A A P P +E + +
Sbjct: 2006 EIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVD 2065
Query: 1282 TSDEAE 1287
++E
Sbjct: 2066 DGTDSE 2071
Score = 48.9 bits (115), Expect = 4e-05
Identities = 94/419 (22%), Positives = 129/419 (30%), Gaps = 66/419 (15%)
Query: 1027 NDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPV 1086
+D SD E S + SS S+ S + + + LP PPR V
Sbjct: 114 SDGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLP----PPRLADV 169
Query: 1087 PTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPR 1146
AP P R G T Q + ++P S P P R
Sbjct: 170 ---APTPPKTPARKRGEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRS----RGR 222
Query: 1147 PDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPP-----------QAKFPGPA 1195
P RP+ P +K++ V A +P PEPPP P + PGP
Sbjct: 223 PPGRPAGPCR-----RKQQAVVVAEAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPG 277
Query: 1196 -------SRKAPRGVERTIRNLPLDHASLVKSWPEEVSRG----GRSRAGGRGRLTEEEE 1244
S + RG R L S ++V G G G+G+ E +
Sbjct: 278 TPRRGGQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQ 337
Query: 1245 AEPGTEVDLAVLADLALTPARRGLPALPAVE---DSEATETSDEAERP--------RPLL 1293
P V + G P E D E E +E E+ R +
Sbjct: 338 DVPQRRVG----------SGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVA 387
Query: 1294 SHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQ 1353
++ A P PP P P P P +SP + P V+ P P
Sbjct: 388 EEMMPAAEKEEAKLPPPPLTPPAPSPPPPLPPP-STSPPPPLCPPPPPPVSPPPLPSPPP 446
Query: 1354 LQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPP 1412
Q E +EE ++ S +R+ R AR PP P P
Sbjct: 447 PPAQEE------QEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTP 499
Score = 45.8 bits (107), Expect = 4e-04
Identities = 87/375 (23%), Positives = 112/375 (29%), Gaps = 127/375 (33%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTS---YLPPEPS-----RPTDQDYRPPASEAPP 434
PPRR+ R P AP + PP TS +PP S PT + PP AP
Sbjct: 1909 PPRRSRRPSPL-APRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGP-APS 1966
Query: 435 PEPPEP-----------------------------------------GGGGGGGGPSPER 453
P PPE G GG G S E
Sbjct: 1967 PPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEE 2026
Query: 454 EEVRTSPR---PASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDT 510
E TS P + + AP T + Q +D +D+
Sbjct: 2027 ESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGVDD----------------GTDS 2070
Query: 511 EEEEENSSMVLGARDTG-----SEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRES 565
E E G +G + V +G P P+ D G PG
Sbjct: 2071 EAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAG 2130
Query: 566 PKANGQNQASPCSSGDD------MEISDDDRG-----GSPP-------PAPTPPQ----- 602
P+ A P ++G +D R G+P PAP PP+
Sbjct: 2131 PREESLPPAPPLANGSQPSQGLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSK 2190
Query: 603 ------------------QPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPP 644
+P PPP PP PP ++ P ++ LPP P P
Sbjct: 2191 IILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTIS------PTAPTSWTLPPGPLLGVLP 2244
Query: 645 EY-----PPPPPPPP 654
PPPPPPP
Sbjct: 2245 VVGVVRPAPPPPPPP 2259
Score = 44.3 bits (103), Expect = 0.001
Identities = 50/202 (24%), Positives = 69/202 (34%), Gaps = 21/202 (10%)
Query: 541 PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP 600
PPPAP +F P + G + S G ++ P P P
Sbjct: 1853 PPPAPRSFSGARIK---VPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAP 1909
Query: 601 PQQPPPPPP-PPPPPPPYLASLPLGY-------PPHQPAYLLPPRPDGPPPPEYPPPPPP 652
P++ P P P PPP AS PL PP L P PP P PPP
Sbjct: 1910 PRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPP 1969
Query: 653 PPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFG 712
P + +E++ L A + F + G + +S G PG +
Sbjct: 1970 PEDLGPDFEDMEVVSGLSA----ADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSE 2025
Query: 713 E------AFLPFPPPQEAAYGL 728
E ++ FP +A GL
Sbjct: 2026 EESSPTSRYIHFPVTVVSAPGL 2047
Score = 43.5 bits (101), Expect = 0.002
Identities = 72/271 (26%), Positives = 89/271 (32%), Gaps = 59/271 (21%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGG 443
PRR E+PP P E + PP TS PP P P AP P PP
Sbjct: 543 PRRFMDEDPPKPPKVEVSPVLRPPITTS--PPVPQEP-----------APVPSPPRAPTP 589
Query: 444 GGGGGPSPE-REEVRTSPR-----------PASPARSGSPAPETTNESVPFAQHSSLDSR 491
P PE R + P P PA PAP S P A +S SR
Sbjct: 590 PSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAP-----SPPPAPATS--SR 642
Query: 492 IEMLLKEQRSKFSFLASDTEEEEENSSMV---LGARDTGSEVPSGSGHGPCTPPPAPA-- 546
+LL+ + F S+ + S + LGA + P + P P P
Sbjct: 643 RPLLLRAPQ----FTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAVGR 698
Query: 547 -------NFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPT 599
F V T P SP P + ++ + P A
Sbjct: 699 TNHLSLPRFAPVVTT----PVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALP 754
Query: 600 PPQQPPPPPPPPPPPPPY-------LASLPL 623
PPQ PPP P PP + SLPL
Sbjct: 755 PPQPQLQPPPSPQQMPPLEKARIAGVGSLPL 785
Score = 43.5 bits (101), Expect = 0.002
Identities = 83/362 (22%), Positives = 123/362 (33%), Gaps = 59/362 (16%)
Query: 1059 ESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARP 1118
E++ E++ PA PS+ PP E P P +V VP G+P P Q P
Sbjct: 1796 EAAEENQTIVHSPA--PSSEPPGGEDP---PLDTDVLVP----GAPERHSPIQNLDP--- 1843
Query: 1119 AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPA 1178
PLRP A P PAPR +P P ++ VSF P
Sbjct: 1844 -----------PLRPDSGSA--PPPAPRSFSGARIKVPNYSPSRRPLGGVSFG-----PL 1885
Query: 1179 PEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGR 1238
P P + P P R+ R PL W A +
Sbjct: 1886 PSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRW-----------ASPPLK 1934
Query: 1239 LTEEEEAEPGTEVDLAVLADLALTPARRGL-PALPAVEDSEATETSDEAERPRPLLSHIL 1297
+ + P T V ALTP L P PA + + E +
Sbjct: 1935 TSPQLRVPPPTSV------VTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSA 1988
Query: 1298 LEHNYALAVKPTPP-------APALRPPEPVPAPAA-LFSSPADEVLEAPEVVVAE---A 1346
+ ++A ++ T P A A+ P ++ SSP + P VV+ A
Sbjct: 1989 ADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLA 2048
Query: 1347 EEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPP 1406
P + ++ +G ++G + E ++ + G G +R L + R RPP
Sbjct: 2049 PSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPPED 2108
Query: 1407 PP 1408
P
Sbjct: 2109 LP 2110
Score = 40.0 bits (92), Expect = 0.019
Identities = 84/381 (22%), Positives = 124/381 (32%), Gaps = 102/381 (26%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPAS--EAPPPEPPEPG 441
P AT P +P + F + ++ P S + + + P + PP+PP+
Sbjct: 499 PSTATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVE 558
Query: 442 GGGGGGGPSPE-REEVRTSPR-PASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQ 499
SP R + TSP P PA SP T S P L + +L+E
Sbjct: 559 -------VSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVP----LPEKRRSILREP 607
Query: 500 RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEP 559
+++ L + PPP PA AP+ P
Sbjct: 608 TFRWTSLTREL------------------------------PPPPPAPPPPPAPSPPPAP 637
Query: 560 GATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPP----PPPPP 615
+ P Q +P + + + +PPP P + P P PPP P P
Sbjct: 638 ATSSRRPLLLRAPQFTP----SEAHLKIYESVLTPPPLGAP-EAPEPEPPPADDSPAEPE 692
Query: 616 PYLA------SLP---------------------LGYPPHQPAYLLPP--------RPDG 640
P SLP L P A LL P P
Sbjct: 693 PRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQA 752
Query: 641 PPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMS------FQMQTQMLTRLHQLR 694
PPP+ PPP P + + A G +P+S F + + +L ++
Sbjct: 753 LPPPQPQLQPPPSPQQMPPLEKARI-----AGVGSLPLSGVEEKMFSLLKRAKVQLFKID 807
Query: 695 QGKGLIAASAGP--PGGAFGE 713
Q + A++ P PGG E
Sbjct: 808 QQQQQKVAASMPLSPGGQMEE 828
Score = 38.1 bits (87), Expect = 0.074
Identities = 62/255 (24%), Positives = 76/255 (29%), Gaps = 47/255 (18%)
Query: 434 PPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIE 493
P P GGGGG GG E VR + R A P E + L +
Sbjct: 21 PGRPRGAGGGGGRGGRGNGAERVRVALRRGGGATG--PGGAEPGEDTALLRLLGLRRGLR 78
Query: 494 MLLK------EQRSKFSFL---------------ASDTEEEEEN------------SSMV 520
L + QR + +SD E +EE SS+
Sbjct: 79 RLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESSDGESDEEEFQGFHSDEDVAPSSLR 138
Query: 521 LGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSG 580
R P G G T P P DVAPT P R QA
Sbjct: 139 SALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPARKRGEEGTERMVQA------ 192
Query: 581 DDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDG 640
+++ R P AP P P PP + P Q A ++
Sbjct: 193 ----LTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPC--RRKQQAVVVAEAAVT 246
Query: 641 PPPPEYPPPPPPPPH 655
P PE PPP P H
Sbjct: 247 IPKPEPPPPVVPVKH 261
Score = 37.0 bits (84), Expect = 0.16
Identities = 52/226 (23%), Positives = 74/226 (32%), Gaps = 65/226 (28%)
Query: 522 GARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGD 581
G R+ + + + + PAP++ P G +P + + SP + D
Sbjct: 1787 GPREEPAHLEAAEENQTIVHSPAPSS----EPPGGEDPPLDTDVLVPGAPERHSPIQNLD 1842
Query: 582 DMEISDDDRGGSPPPAP-------------TPPQQPP-----PPPPPPPPPPPYLASLPL 623
D G +PPPAP +P ++P P P P P +P
Sbjct: 1843 PP--LRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPT 1900
Query: 624 GYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQ 683
P PA PPR P P P PPP ++W P+ Q
Sbjct: 1901 VGDPDFPA---PPRRSRRPSPLAPRPPP-------------------SRWASPPLKTSPQ 1938
Query: 684 ------TQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQE 723
T ++T L + PPG A P PPP E
Sbjct: 1939 LRVPPPTSVVTALTP-------TSGELAPPGPA------PSPPPPE 1971
Score = 34.7 bits (78), Expect = 0.82
Identities = 34/134 (25%), Positives = 42/134 (31%), Gaps = 30/134 (22%)
Query: 537 GPCTPPPAPAN------------FEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDME 584
GP PP PA F +A G P ++ P + +P S
Sbjct: 2178 GPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLPPTISPTAPTS------ 2231
Query: 585 ISDDDRGGSPPPAPTPPQQPP-----PPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPD 639
+ PP P P P PPPPPPP + S PP Q +
Sbjct: 2232 -------WTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQAIRVKRVSTF 2284
Query: 640 GPPPPEYPPPPPPP 653
P PPP P
Sbjct: 2285 SGRSPPAPPPYKAP 2298
Score = 32.3 bits (72), Expect = 4.0
Identities = 43/158 (27%), Positives = 56/158 (35%), Gaps = 36/158 (22%)
Query: 1066 EEEERPAALPSASPP--------PREVPVPTPAPVEVP--VPERVAGSPVTPLPEQEASP 1115
+ +E P A P P PRE V P P E + + A V P +
Sbjct: 1031 DSDESPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIF- 1089
Query: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPA----PAPRPDERPSSPIPLLPP--PKKRRKTVS 1169
E+S S P PP P P P P P+E+ P L P K R+ +
Sbjct: 1090 -------EDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRPRKPTLQPVLQLKARRRLD 1142
Query: 1170 FSAIEVVPAPEPPPATPPQAKFPG--PASRKAPRGVER 1205
A+ A P A FP +K+P GV R
Sbjct: 1143 KDAL----------APGPFASFPNGWTGKQKSPDGVHR 1170
Score = 32.3 bits (72), Expect = 4.0
Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 9/101 (8%)
Query: 913 RPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQES 972
RP PA E+ P QE+ P P PP+ + L+S+ S E+
Sbjct: 2339 RPGEPAGEESPGPLQERSPLLP-LPEDGPPQVPDGP--------PDLLLESQWHHYSGEA 2389
Query: 973 SSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDS 1013
SS ++E +D+E++ + + E DG E++S
Sbjct: 2390 SSSEEEPPSPDDKENQAPKRTGPHLRFEISSEDGFSVEAES 2430
Score = 31.2 bits (69), Expect = 9.0
Identities = 20/43 (46%), Positives = 20/43 (46%), Gaps = 7/43 (16%)
Query: 420 PTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRP 462
P D D P AS P PP P G G GG REEV P P
Sbjct: 1029 PWDSDESPEAS----PGPPGPRRGAGAGG---PREEVVAHPGP 1064
Score = 31.2 bits (69), Expect = 9.0
Identities = 38/138 (27%), Positives = 43/138 (31%), Gaps = 42/138 (30%)
Query: 367 PAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPP------EPSRP 420
PA+ E+ Q P A EPPG PP T L P P +
Sbjct: 1792 PAHLEAAEENQTIVHSP---APSSEPPGG--------EDPPLDTDVLVPGAPERHSPIQN 1840
Query: 421 TDQDYRPPASEAPPPEPPEPGG---------------GGGGGGPSPER----------EE 455
D RP + APPP P G GG GP P
Sbjct: 1841 LDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPT 1900
Query: 456 VRTSPRPASPARSGSPAP 473
V PA P RS P+P
Sbjct: 1901 VGDPDFPAPPRRSRRPSP 1918
>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
sapiens]
Length = 3969
Score = 150 bits (380), Expect = 8e-36
Identities = 78/146 (53%), Positives = 96/146 (65%), Gaps = 3/146 (2%)
Query: 1564 KFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSY 1623
K K+ + RS IH GLF I A EMVIEY G IR + D REK Y +GIG Y
Sbjct: 3825 KTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGC-Y 3883
Query: 1624 LFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYD 1683
+FR+D ++DAT GN ARFINH C PNCY++VI I+ QK IVI++ + I EE+TYD
Sbjct: 3884 MFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYD 3943
Query: 1684 YKFPLED--NKIPCLCGTESCRGSLN 1707
YKFP+ED NK+PC CG + CR LN
Sbjct: 3944 YKFPIEDASNKLPCNCGAKKCRKFLN 3969
Score = 56.2 bits (134), Expect = 3e-07
Identities = 65/234 (27%), Positives = 93/234 (39%), Gaps = 24/234 (10%)
Query: 1034 ESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVE 1093
E S +S S SS + SS+ + E+ P S+ PPPR+ PVE
Sbjct: 1217 EKKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKK-SSSEPPPRK-------PVE 1268
Query: 1094 VPVPERVAGSPVTPLPE--QEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERP 1151
E G+ P PE Q +PA + S P+ + PP+PP P P P
Sbjct: 1269 EKSEE---GNVSAPGPESKQATTPASRKSSKQVSQPALVI-PPQPPTTGPPRKEVPKTTP 1324
Query: 1152 SSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAK-FPGPASRKAPRGVERTIRNL 1210
S P PPP + S +V P P P P+ K P P +++ G + L
Sbjct: 1325 SEPKKKQPPPPESGPEQS-KQKKVAPRPSIPVKQKPKEKEKPPPVNKQENAGTLNILSTL 1383
Query: 1211 PLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEV-DLAVLADLALTP 1263
++S K + V R R E+ EAE E+ L +L + +TP
Sbjct: 1384 SNGNSSKQKIPADGVHR-------IRVDFKEDCEAENVWEMGGLGILTSVPITP 1430
Score = 49.7 bits (117), Expect = 2e-05
Identities = 138/608 (22%), Positives = 205/608 (33%), Gaps = 115/608 (18%)
Query: 623 LGYPPHQ--PAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMS- 679
LG P Q PA LLPP GPP P PP P + G G S
Sbjct: 27 LGGAPRQRVPALLLPP---GPPVGGGGPGAPPSPPAVAAAAAAAGSSGAGVPGGAAAASA 83
Query: 680 ----------------------------FQMQTQMLTRLH-QLRQGKGLIAASAGPPGGA 710
F Q+ + LR+ + + S G G
Sbjct: 84 ASSSSASSSSSSSSSASSGPALLRVGPGFDAALQVSAAIGTNLRRFRAVFGESGGGGGSG 143
Query: 711 FGEAFLPFPPPQEAAYGLPY---ALYAQGQEGRG----AYSREAYHLPMPMAAEPLPSSS 763
E FL F +E P ++ ++ RG R + L P PL S
Sbjct: 144 EDEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSE 203
Query: 764 V-SGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGA 822
SG++ + + E G+ G ++K +D++ N
Sbjct: 204 TKSGDKIKKKDSKSIEKKRGRPPTFPGV----------KIKITHGKDISELPKGN----- 248
Query: 823 FDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSG----GTTGIEAF 878
KE+ K + ++ K K KL+ L L K+G G G++
Sbjct: 249 -------KEDSLKKIKRTPSATFQQATKIK-KLRAGKLSPLKSKFKTGKLQIGRKGVQI- 299
Query: 879 AFGSGLRGALRLPSFKVKRKEPSEISEASEEKRP------RPSTP--AEEDEDDPEQEKE 930
+R R PS + + K PS + SE ++P + TP +ED+ Q
Sbjct: 300 -----VRRRGRPPSTE-RIKTPSGLLINSELEKPQKVRKDKEGTPPLTKEDKTVVRQSPR 353
Query: 931 AGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDR 990
+P R + D K + K A +EA+Q + + +
Sbjct: 354 RIKPVRIIPSSKRTDATIAKQLLQRAKKGAQKKIEKEAAQLQGRKVKTQVKNIRQFIMPV 413
Query: 991 EEAVDTTKKETEVSDGEDEESD---------SSSKCSLYADSDGENDSTSDSESSSSSSS 1041
A+ + +T EDE+ D S+ A S G ++ +S + SS S
Sbjct: 414 VSAISSRIIKTPRRFIEDEDYDPPIKIARLESTPNSRFSAPSCGSSEKSSAASQHSSQMS 473
Query: 1042 SSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVE-------- 1093
S SS SSS S +S+ S++S E + E + P PP +P+ E
Sbjct: 474 SDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPP---LPISQSPENESNDRRSRR 530
Query: 1094 VPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSS 1153
V ER GS T + + P T SPP PP P P +P S
Sbjct: 531 YSVSERSFGSRTT--KKLSTLQSAPQQQTSSSPP--------PPLLTPPPPLQPASSISD 580
Query: 1154 PIPLLPPP 1161
P L PP
Sbjct: 581 HTPWLMPP 588
Score = 47.4 bits (111), Expect = 1e-04
Identities = 41/177 (23%), Positives = 64/177 (36%), Gaps = 19/177 (10%)
Query: 990 REEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSS 1049
+++A KKE + E ++S SS DS S + S+ + SSS
Sbjct: 1207 QKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDS-------SQKPTPSAREDPAPKKSSS 1259
Query: 1050 SSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLP 1109
E S E P + + +P R+ P V P+ P T P
Sbjct: 1260 EPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQ----PPTTGPP 1315
Query: 1110 EQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRK 1166
+E P+ P ++ PP PP P + + P IP+ PK++ K
Sbjct: 1316 RKEVPKTTPSEPKKKQPP--------PPESGPEQSKQKKVAPRPSIPVKQKPKEKEK 1364
Score = 45.8 bits (107), Expect = 4e-04
Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 25/174 (14%)
Query: 1015 SKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAAL 1074
SK L + S++S S SS + SS + S+ ED PA
Sbjct: 1202 SKAYLQKQAKAVKKKEKKSKTSEKKDSKESSVVKNVVDSSQKPTPSARED------PAPK 1255
Query: 1075 PSASPPPREVPVPTPAP---VEVPVPE-------------RVAGSPVTPLPEQEASPARP 1118
S+S PP PV + V P PE + P +P Q + P
Sbjct: 1256 KSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPP 1315
Query: 1119 AGPTEESPPSAPLR--PPEPPAGPP-APAPRPDERPSSPIPLLPPPKKRRKTVS 1169
++ PS P + PP P +GP + + RPS P+ P K++ V+
Sbjct: 1316 RKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPPVN 1369
Score = 42.4 bits (98), Expect = 0.004
Identities = 117/607 (19%), Positives = 195/607 (32%), Gaps = 110/607 (18%)
Query: 466 ARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARD 525
+R +P+ ++ +S +QHSS +M RS + + T+ + VL
Sbjct: 449 SRFSAPSCGSSEKSSAASQHSS-----QMSSDSSRSSSPSVDTSTDSQASEEIQVL---- 499
Query: 526 TGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEI 585
P P PP P + +SP+ ++ S S +
Sbjct: 500 -----PEERSDTPEVHPPLPIS----------------QSPENESNDRRSRRYSVSERSF 538
Query: 586 SDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPE 645
P QQ PPPP PP PP QPA + PP
Sbjct: 539 GSRTTKKLSTLQSAPQQQTSSSPPPPLLTPP---------PPLQPASSISDHTPWLMPPT 589
Query: 646 YPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRL-HQLRQGKGLIAASA 704
P P P G + T T L H + + +A
Sbjct: 590 IPLASPFLPA------------STAPMQGKRKSILREPTFRWTSLKHSRSEPQYFSSAKY 637
Query: 705 GPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAE-PLPSSS 763
G F F PP + +A G G + P+ + S
Sbjct: 638 AKEGLIRKPIFDNFRPPPLTPEDVGFA---SGFSASGTAASARLFSPLHSGTRFDMHKRS 694
Query: 764 VSGEEARLPPRE-EAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGA 822
R P E + + E TLP+ T + + R RK+ +
Sbjct: 695 PLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSS------SGVSNRKRKRKVFSPI---- 744
Query: 823 FDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGS 882
+ E P + + + E + L P +S S + + A S
Sbjct: 745 -------RSEPRSPSHSMRTRSGRLSSSELSPLTPPSSVS------SSLSISVSPLAT-S 790
Query: 883 GLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPP 942
L PS + + S A + +RPR T A + PG++
Sbjct: 791 ALNPTFTFPSHSLTQSGES----AEKNQRPRKQTSAPAEPFSSSSPTPLFPWFTPGSQT- 845
Query: 943 KRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETE 1002
ERG+ + K + + D + +++ ++ +K E D E E++ RE + KK +E
Sbjct: 846 ----ERGRNKDKAPEELSKDRDADKSVEK---DKSRERDREREKENKRESRKEKRKKGSE 898
Query: 1003 VSDGEDEESDSSSKCSLYADSD-------GENDSTSDSESSSSSSSSSSSSSSSSSSSSS 1055
+ S +LY GE+ +TS S ++ SSS S + +S
Sbjct: 899 IQ----------SSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGTDITSV 948
Query: 1056 SSSESSS 1062
+ ++++
Sbjct: 949 TLGDTTA 955
Score = 41.6 bits (96), Expect = 0.007
Identities = 76/402 (18%), Positives = 149/402 (37%), Gaps = 55/402 (13%)
Query: 773 PREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEE 832
P E E + P++ TV + + + + + K V ++ A Q + ++
Sbjct: 981 PSLEKEKTLCLSTPSSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKIEKS 1040
Query: 833 KAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPS 892
K+ + K Q +E D +T ++ P + + ++ G + F + LP
Sbjct: 1041 KSLKQTDQPKAQGQESDSSETSVRGPRIKHVC--RRAAVALGRKRAVFPDDMPTLSALP- 1097
Query: 893 FKVKRKEPSEISE-------ASEEKRP-----RPSTPAEEDEDDPEQEKEAGEPGR---- 936
++ + K S + SE+ P +P P ++ E + G R
Sbjct: 1098 WEEREKILSSMGNDDKSSIAGSEDAEPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQ 1157
Query: 937 -PGTKPPK------RDEERGKTQGKHRKSFA-----------LDSEGEEASQESSSEKDE 978
PG + P+ ++ K G++ K + S+ Q + +K E
Sbjct: 1158 CPGCQVPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKE 1217
Query: 979 EDDEEDEEDEDREEAV-----DTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDS 1033
+ + E+ + +E +V D+++K T + + SSS E
Sbjct: 1218 KKSKTSEKKDSKESSVVKNVVDSSQKPTPSAREDPAPKKSSS----------EPPPRKPV 1267
Query: 1034 ESSSSSSSSSSSSSSSSSSSSSSSSESSSE-DEEEEERPAALPSASPPPREVPVPTPAPV 1092
E S + S+ S +++ +S +SS + + P P+ PP +EVP TP+
Sbjct: 1268 EEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEP 1327
Query: 1093 EVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPP 1134
+ P P +Q+ RP+ P ++ P PP
Sbjct: 1328 KKKQPPPPESGP--EQSKQKKVAPRPSIPVKQKPKEKEKPPP 1367
Score = 39.3 bits (90), Expect = 0.033
Identities = 22/41 (53%), Positives = 29/41 (70%)
Query: 316 ASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSS 356
A++A+ S+ A A+S+ASSSS SSSSSSSSS+SS
Sbjct: 61 AAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASS 101
Score = 38.1 bits (87), Expect = 0.074
Identities = 44/204 (21%), Positives = 83/204 (40%), Gaps = 12/204 (5%)
Query: 223 DTAAYPAGTTAVGTPGNG---TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGST 279
+ + +G +A GT + +P T F ++ +FTP + + S +
Sbjct: 659 EDVGFASGFSASGTAASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESV-TL 717
Query: 280 PYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSA 339
P ++ SA +SS+ ++ K +R FS S S + T +++ S
Sbjct: 718 PSNRTSAGTSSSGVSNRKRKRK------VFSPIRSEPRSPSHSMRTRSGRLSSSELSPLT 771
Query: 340 SSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAE 399
SS+SSS S S S ++ + +P++ + + + PR+ T P PF+
Sbjct: 772 PPSSVSSSLSISVSPLATSALNPTFTFPSHSLTQSGESAEKNQRPRKQT--SAPAEPFSS 829
Query: 400 NTAERFPPSYTSYLPPEPSRPTDQ 423
++ P +T E R D+
Sbjct: 830 SSPTPLFPWFTPGSQTERGRNKDK 853
Score = 37.0 bits (84), Expect = 0.16
Identities = 20/43 (46%), Positives = 31/43 (72%)
Query: 315 SASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSS 357
+ ++A+ A ++ A A++SA+SSS +SSSSSSSSS+SS
Sbjct: 59 AVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASS 101
Score = 37.0 bits (84), Expect = 0.16
Identities = 40/163 (24%), Positives = 60/163 (36%), Gaps = 19/163 (11%)
Query: 497 KEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGS 556
KE++SK S +++ + SS+V D+ S+ P+ S P + + P
Sbjct: 1216 KEKKSKTS-----EKKDSKESSVVKNVVDS-SQKPTPSAREDPAPKKSSSEPPPRKPVEE 1269
Query: 557 GEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPT-PPQQPPPPPPPPPP-- 613
+P + +P S ++S P P T PP++ P P P
Sbjct: 1270 KSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKK 1329
Query: 614 --PPPYLASLPLGYPPHQPAYLLPPRPDGP---PPPEYPPPPP 651
PPP P P + PRP P P E PPP
Sbjct: 1330 KQPPP-----PESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPP 1367
Score = 35.0 bits (79), Expect = 0.62
Identities = 20/46 (43%), Positives = 29/46 (63%)
Query: 317 SSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSS 362
S + A+ A A ++ A A+++S +SSSS+SSSSSSS SS
Sbjct: 56 SPPAVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASS 101
Score = 35.0 bits (79), Expect = 0.62
Identities = 18/46 (39%), Positives = 32/46 (69%)
Query: 315 SASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFR 360
+A++A+ ++ + AA +++S+SS+S SSSSSSS+SS + R
Sbjct: 62 AAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPALLR 107
Score = 34.3 bits (77), Expect = 1.1
Identities = 23/46 (50%), Positives = 29/46 (63%), Gaps = 7/46 (15%)
Query: 326 AIAATTAATASS-------SASSSSLSSSSSSSSSSSSSQFRSSDA 364
A+AA AA SS +A++S+ SSSS+SSSSSSSS S A
Sbjct: 59 AVAAAAAAAGSSGAGVPGGAAAASAASSSSASSSSSSSSSASSGPA 104
Score = 33.9 bits (76), Expect = 1.4
Identities = 27/98 (27%), Positives = 40/98 (40%), Gaps = 14/98 (14%)
Query: 384 PRRATREEPPGAPFAENTAE---RFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEP 440
P++++ E PP P E + E P + SR + + PA PP+PP
Sbjct: 1254 PKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPAL-VIPPQPPTT 1312
Query: 441 GGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNE 478
G P R+EV P+ P + P PE+ E
Sbjct: 1313 G---------PPRKEV-PKTTPSEPKKKQPPPPESGPE 1340
Score = 33.5 bits (75), Expect = 1.8
Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 3/87 (3%)
Query: 1342 VVAEAEEPKPQQLQQ---QREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHA 1398
VV +++P P + ++ E + EE+ EE + S+ + + A S +S
Sbjct: 1237 VVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSK 1296
Query: 1399 RRRRPPPPPPPPPPRAYEPRSEFEQMT 1425
+ +P PP PP PR E + T
Sbjct: 1297 QVSQPALVIPPQPPTTGPPRKEVPKTT 1323
Score = 33.5 bits (75), Expect = 1.8
Identities = 24/76 (31%), Positives = 28/76 (36%), Gaps = 17/76 (22%)
Query: 596 PAPTPPQQPPPPPPP-----------PPPPPPYLASLPLGYPPH----QPAYLLPPRP-- 638
PAP PPP P P P A+ P QPA ++PP+P
Sbjct: 1252 PAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASRKSSKQVSQPALVIPPQPPT 1311
Query: 639 DGPPPPEYPPPPPPPP 654
GPP E P P P
Sbjct: 1312 TGPPRKEVPKTTPSEP 1327
Score = 32.7 bits (73), Expect = 3.1
Identities = 38/143 (26%), Positives = 56/143 (39%), Gaps = 6/143 (4%)
Query: 224 TAAYPAGTT-AVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTS-RGSTPY 281
+A P TT + T G+ S S S R T S +PQ S+ + R Y
Sbjct: 2164 SAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSS----LSPQRSKLRIMSPMRTGNTY 2219
Query: 282 SQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASS 341
S+++ S STT T+ S + S S T++++ T T + S
Sbjct: 2220 SRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSH 2279
Query: 342 SSLSSSSSSSSSSSSSQFRSSDA 364
SSSS SS+S S +
Sbjct: 2280 LDGSSSSEMKQSSASDLVSKSSS 2302
Score = 32.3 bits (72), Expect = 4.0
Identities = 43/189 (22%), Positives = 66/189 (34%), Gaps = 15/189 (7%)
Query: 1008 DEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
D+ +DS+ + D D E + S S+ SS + SSS +S E +E
Sbjct: 2380 DQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKE 2439
Query: 1068 EERPAAL--PSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEES 1125
+ + P E + EV PE + P + + G S
Sbjct: 2440 KHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDK------IGDKGLS 2493
Query: 1126 PPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPAT 1185
P P PP G P +R L P K ++ S +A++ E PA+
Sbjct: 2494 MPGVPKAPPMQVEGSAKELQAPRKRTVK--VTLTPLKMENESQSKNALK-----ESSPAS 2546
Query: 1186 PPQAKFPGP 1194
P Q + P
Sbjct: 2547 PLQIESTSP 2555
Score = 32.3 bits (72), Expect = 4.0
Identities = 106/469 (22%), Positives = 155/469 (33%), Gaps = 87/469 (18%)
Query: 923 DDPEQ--EKEAGEPGRPGTK-PPKRDE----ERGKTQGKHRKSFALDSEGEEASQESSSE 975
D PE EKE G K PK D R KTQG+ L S +S+
Sbjct: 2756 DRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTP 2815
Query: 976 KDE-----------EDDEEDEEDED-----REEAVDTTKKETEVSDGEDEESDSSSKCSL 1019
D+ + D ++ +D + +D K T E +SSS L
Sbjct: 2816 SDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELL 2875
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPS--- 1076
DS + + S ++ SS SSS S+ EE+ E P LPS
Sbjct: 2876 NLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISA---EEQFELPLELPSDLS 2932
Query: 1077 ----------ASPPPREVPVPTPAPVEVPVPERVAGSP----------VTPLPEQEASPA 1116
+ P R + V + E+ S V P PE +P
Sbjct: 2933 VLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPD 2992
Query: 1117 R--PAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPP-PKKRRKTVSFSAI 1173
+ S P E G R P +P+ P P + +K V S
Sbjct: 2993 HFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTD 3052
Query: 1174 EVVPAPEPPPA---TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGR 1230
P+ A TPP K PA+ K + N + ++++ P V++
Sbjct: 3053 SPGPSQISNAAVQTTPPHLK---PATEKL------IVVNQNMQPLYVLQTLPNGVTQ--- 3100
Query: 1231 SRAGGRGRLTEEEEAEPGT-EVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERP 1289
+ +LT + P E + +VL P GL + S T S
Sbjct: 3101 -----KIQLTSSVSSTPSVMETNTSVLG-----PMGGGLTLTTGLNPSLPTSQSLFPSAS 3150
Query: 1290 RPLL--SHILLEHNYALAVKPTPPAPALRPP-------EPVPAPAALFS 1329
+ LL SH H++ A + + P PP +P P P L S
Sbjct: 3151 KGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVS 3199
Score = 31.2 bits (69), Expect = 9.0
Identities = 33/118 (27%), Positives = 43/118 (36%), Gaps = 20/118 (16%)
Query: 336 SSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTS--YPP--------- 384
SS+AS S SS SS SSS S S+D+ + + T +PP
Sbjct: 462 SSAASQHSSQMSSDSSRSSSPSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPEN 521
Query: 385 ----RRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPP 438
RR+ R F T ++ S L P + T PP PPP P
Sbjct: 522 ESNDRRSRRYSVSERSFGSRTTKKL-----STLQSAPQQQTSSSPPPPLLTPPPPLQP 574
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 129 bits (324), Expect = 2e-29
Identities = 66/143 (46%), Positives = 92/143 (64%), Gaps = 3/143 (2%)
Query: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
K + RSRI GL+A + + MVIEY+G IR VA+ REK Y ++ G Y+FR
Sbjct: 5396 KNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGI-YMFR 5454
Query: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
++++ +IDAT G AR+INH C PNC A+V+T + + KI+I S + I EE+TYDY+F
Sbjct: 5455 INNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQF 5514
Query: 1687 PLED--NKIPCLCGTESCRGSLN 1707
ED +KIPC CG +CR +N
Sbjct: 5515 DFEDDQHKIPCHCGAWNCRKWMN 5537
Score = 88.6 bits (218), Expect = 5e-17
Identities = 132/437 (30%), Positives = 170/437 (38%), Gaps = 77/437 (17%)
Query: 1043 SSSSSSSSSSSSSSSSESSSEDEEEEERPAA-LPSA------------SPPPREVPVPTP 1089
S S S +S E+S EE PA+ LP A SPPP E P+ P
Sbjct: 447 SPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPP 506
Query: 1090 ------APVE---VPVPERVAGSPV--TPL-PEQEASPARPAGPTEESPPSAPLRPPEPP 1137
+P+E + PE SP TPL P EASP P P EESP S P P E P
Sbjct: 507 PESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSP--PFEESPLSPP--PEELP 562
Query: 1138 AGPPAPA----PRPDERPSSP----IPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQA 1189
PP A P P+E P SP P+ PPP+ R F + P PE P +PP
Sbjct: 563 TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPP- 621
Query: 1190 KFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEE--AEP 1247
ASR +P + + P + S P EVSR R EE + P
Sbjct: 622 ----EASRLSPPPEDSPMSPPPEESP---MSPPPEVSRLSPLPVVSRLSPPPEESPLSPP 674
Query: 1248 GTEVDLAVLADLA-LTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILL-------- 1298
E + + + L+P P P EDS A+ +++ PL LL
Sbjct: 675 PEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQL 734
Query: 1299 ---EHNYALAVKPTPPAPALRPPEPVPAPAA----LFSSPADEVLEA-PEV--VVAEAE- 1347
L+ +P P + RP EP +P A L P + L A PE + +AE
Sbjct: 735 CPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEG 794
Query: 1348 ---EPKPQQLQQQREEGEEEGEEEGEE-----EEEESSDSSSSSDGEGALRRRSLRSHAR 1399
P+P++L + E EE + EES S S E L R SH
Sbjct: 795 PHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSE--EPCLSPRPEESHLS 852
Query: 1400 RRRPPPPPPPPPPRAYE 1416
PP P P + E
Sbjct: 853 PELEKPPLSPRPEKPPE 869
Score = 76.6 bits (187), Expect = 2e-13
Identities = 126/519 (24%), Positives = 180/519 (34%), Gaps = 68/519 (13%)
Query: 883 GLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPP 942
G G P + E + EE P P EE P E P P + P
Sbjct: 420 GKAGVQLEPQLEAPLNEEMPLLPPPEESPLSP--PPEESPTSPPPEASRLSP--PPEELP 475
Query: 943 KRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETE 1002
+ + L EE+ E E+ EE+ + ET
Sbjct: 476 ASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETP 535
Query: 1003 VSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSS 1062
+S + +S S + + + +S +S S S S ES
Sbjct: 536 LSPPPE-----ASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPM 590
Query: 1063 EDEEEEER---PAALPSASPPPREVPVP--------TPAPVEVPVPERVAGSPVTPLPE- 1110
E R P SPPP E P+ +P P + P+ SP++P PE
Sbjct: 591 SPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEV 650
Query: 1111 QEASP----ARPAGPTEESPPSAPLRPPEPPAGPPAPA----PRPDERPSSP----IPLL 1158
SP +R + P EESP S P P E P PP A P P++ P+SP P
Sbjct: 651 SRLSPLPVVSRLSPPPEESPLSPP--PEESPTSPPPEASRLSPPPEDSPTSPPPEDSPAS 708
Query: 1159 PPPKKRRKTVSFSAIEVVPAPEPPPATP--------PQAKFPGPASRK-----APRGVER 1205
PPP+ ++ ++P PE P P P+ + P + R +P+ E
Sbjct: 709 PPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEP 768
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265
+ P + + PEE ++ EE P TE + L+P
Sbjct: 769 HLS--PQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTE-------EPHLSPVP 819
Query: 1266 RGLPALPAVEDSEATETSDE-AERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAP 1324
P E+S + S+E PRP SH+ E L P P P P EP P
Sbjct: 820 EEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE----LEKPPLSPRPEKPPEEPGQCP 875
Query: 1325 A----ALFSSPADEVLE--APEVVVAEAEEPKPQQLQQQ 1357
A LF P + L E ++E EP L ++
Sbjct: 876 APEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEE 914
Score = 72.0 bits (175), Expect = 5e-12
Identities = 86/282 (30%), Positives = 109/282 (38%), Gaps = 25/282 (8%)
Query: 390 EEPPGAPFAENTAERFPPSYTSYLPPE--PSRPTDQDYRPPASEAPPPEPPE--PGGGGG 445
EE P +P E + PP + + P E P P ++ PA E P PPE P
Sbjct: 490 EESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF 549
Query: 446 GGGP-SPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFS 504
P SP EE+ TSP P A SP PE + S P + S + E + S
Sbjct: 550 EESPLSPPPEELPTSPPPE--ASRLSPPPEESPMSPP-PEESPMSPPPEASRLFPPFEES 606
Query: 505 FLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPP--APANFEDVAPTGSGEPGAT 562
L+ EE L S + P +PPP +P + S P +
Sbjct: 607 PLSPPPEESP------LSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660
Query: 563 RESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLP 622
R SP ++ SP + SPPP +P PP P PPP L SLP
Sbjct: 661 RLSPPPE-ESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLP 719
Query: 623 LGYPPHQPAYLLP---PRPDGP---PPPEYP--PPPPPPPHI 656
L P P P PR +GP P PE P P P PH+
Sbjct: 720 LEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHL 761
Score = 65.9 bits (159), Expect = 3e-10
Identities = 106/439 (24%), Positives = 148/439 (33%), Gaps = 91/439 (20%)
Query: 394 GAPFAENTAERFPPSYTSYLPPEPS-RPTDQ--------DYRPPASEAPPPEPPEPGG-- 442
G + AE+ P + + PPEP PTD+ +P +P EPG
Sbjct: 354 GGQTIRSVAEQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQ 413
Query: 443 ------GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV--PFAQHSSLDSRIEM 494
G G P+ E P P SP ES P + S L E
Sbjct: 414 CEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEE 473
Query: 495 LLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPP-----APANFE 549
L + L+ EE S + P +PPP +P
Sbjct: 474 LPASPLPEALHLSRPLEE---------------SPLSPPPEESPLSPPPESSPFSPLEES 518
Query: 550 DVAPTGSGEPGATRESPKANGQNQASPCS---SGDDMEISDDDRGGSPPPAPT----PPQ 602
++P P E+P + +ASP S + ++ SPPP + PP+
Sbjct: 519 PLSPPEESPPSPALETP-LSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPE 577
Query: 603 QPPPPPPP---PPPPPPYLASL-------PLGYPPHQP--------AYLLPPRPDGP--P 642
+ P PPP P PPP + L PL PP + + L PP D P P
Sbjct: 578 ESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSP 637
Query: 643 PPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAA 702
PPE P PPP ++ L ++ RL P+S + + + L
Sbjct: 638 PPEESPMSPPPE--VSRLSPLPVVSRLSPPPEESPLSPPPEESPTS---PPPEASRLSPP 692
Query: 703 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSS 762
P E PPP+++ LP E+ LP+P + P S
Sbjct: 693 PEDSPTSPPPEDSPASPPPEDSLMSLPL--------------EESPLLPLPEEPQLCPRS 738
Query: 763 -----SVSGEEARLPPREE 776
S EE L PR E
Sbjct: 739 EGPHLSPRPEEPHLSPRPE 757
Score = 63.5 bits (153), Expect = 2e-09
Identities = 99/412 (24%), Positives = 137/412 (33%), Gaps = 76/412 (18%)
Query: 1067 EEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVT------PLPEQ-EASPARPA 1119
E+ P + P P + P P + V + G VT P P Q EA P A
Sbjct: 363 EQHTPVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKA 422
Query: 1120 G-------------------PTEESPPSAPLRPPEPPAGPPAPA----PRPDERPSSPI- 1155
G P EESP S P P E P PP A P P+E P+SP+
Sbjct: 423 GVQLEPQLEAPLNEEMPLLPPPEESPLSPP--PEESPTSPPPEASRLSPPPEELPASPLP 480
Query: 1156 ------------PLLPPPKKR-----RKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198
PL PPP++ ++ FS +E P PP +PP P S
Sbjct: 481 EALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPL-SPPEESPPSPALETPLSPP 539
Query: 1199 APRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLAD 1258
E + + P + + L PEE+ A EE P E +
Sbjct: 540 P----EASPLSPPFEESPLSPP-PEELPTSPPPEASRLSPPPEESPMSPPPE-------E 587
Query: 1259 LALTPARRGLPALPAVEDSEATETSDEAE-RPRPLLSHILLEHNYALAVKPTPPAPALRP 1317
++P P E+S + +E+ P P S + + P +P P
Sbjct: 588 SPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPP 647
Query: 1318 PE-----PVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEE 1372
PE P+P + L P + L P + P+ +L E+ E
Sbjct: 648 PEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPA 707
Query: 1373 EEESSDSSSSSDGEGA-------LRRRSLRSHARRRRPPPPPPPPPPRAYEP 1417
DS S E + + RS P P P PR EP
Sbjct: 708 SPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEP 759
Score = 59.3 bits (142), Expect = 3e-08
Identities = 198/927 (21%), Positives = 285/927 (30%), Gaps = 190/927 (20%)
Query: 531 PSGSGHGPCTPPPAPANFED---VAPTGSGEPG-ATRESPKANG--QNQASPCS-SGDDM 583
P S P P P + D VA G + G T PK G Q +A P +G +
Sbjct: 367 PVCSRFSPPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQL 426
Query: 584 EISDDDRGGSPPPAPTPPQQPPPPPPP---PPPPPPYLASLPLGYPPHQPAYLLPPRPDG 640
E + P PP++ P PPP P PPP + L
Sbjct: 427 EPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRL------------------S 468
Query: 641 PPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLI 700
PPP E P P P LE L P+S ++ + L + L
Sbjct: 469 PPPEELPAS--PLPEALHLSRPLE-ESPLSPPPEESPLSPPPESSPFSPLEE----SPLS 521
Query: 701 AASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLP 760
PP A P PP+ + P+ P+ E LP
Sbjct: 522 PPEESPPSPALETPLSP--PPEASPLSPPFE-----------------ESPLSPPPEELP 562
Query: 761 SSSVSGEEARLPPREEAELA---EGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVEN 817
+S PP EE+ ++ E + R+ + S
Sbjct: 563 TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSP------------ 610
Query: 818 VAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEA 877
+E P A++ ED + E +S + +
Sbjct: 611 ----------PPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVS 660
Query: 878 FAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDE--DDPEQEKEAGEPG 935
L P + P E S S P++P ED P ++ P
Sbjct: 661 RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL 720
Query: 936 RPGTKPPKRDEER--GKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDE---EDEDR 990
P +E + +++G H L EE E+ + +E +
Sbjct: 721 EESPLLPLPEEPQLCPRSEGPH-----LSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPE 775
Query: 991 EEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSD--SESSSSSSSSSSSSSS 1048
E + +E +S + S L+ E S E S S S
Sbjct: 776 EPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSP 835
Query: 1049 SSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERV-------- 1100
S S S E E+P P PP E P + P PE +
Sbjct: 836 QSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEE-------PGQCPAPEELPLFPPPGE 888
Query: 1101 ---------------AGSPVTPLPEQEASPARPAGPTEESP---PSAPLRPPEPP----A 1138
P++PLPE+ P P+G SP P PL PP P A
Sbjct: 889 PSLSPLLGEPALSEPGEPPLSPLPEE--LPLSPSGEPSLSPQLMPPDPLPPPLSPIITAA 946
Query: 1139 GPPAPAP----------RPDERPSSPI-------PLLPPPKKRRKTVSFSAIEVVPAPEP 1181
PPA +P + D P SP+ P+ PPP+ A P P P
Sbjct: 947 APPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPE---------ANCTDPEPVP 997
Query: 1182 PPATPPQAKFP-GPAS----RKAPRGVERTI------RNLPLDHAS---LVKSWPEEVSR 1227
P PP P GPAS P + +N P S L S P +S
Sbjct: 998 PMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSP 1057
Query: 1228 GGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAE 1287
G+ E E E +E + L A +P LP S + S A
Sbjct: 1058 IGKVVGVSDEAELHEMETEKVSEPECPALEPSATSP----LP-------SPMGDLSCPAP 1106
Query: 1288 RPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAE 1347
P P L +++ + T P + P P P S A E+ +P ++ E
Sbjct: 1107 SPAPALD------DFSGLGEDTAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEEL 1160
Query: 1348 EP-KPQQLQQQREEGEEEGEEEGEEEE 1373
P P ++ + ++ +G E+EE
Sbjct: 1161 APVTPMEVYPECKQTAGQGSPCEEQEE 1187
Score = 55.5 bits (132), Expect = 4e-07
Identities = 82/294 (27%), Positives = 111/294 (37%), Gaps = 47/294 (15%)
Query: 390 EEPPGAPFAENTAERFPPSYTSYLPPEPS------RPTDQDYRPPASE---APPPEPP-- 438
EE P P E + P S +L P P RP + P A E +P PE P
Sbjct: 721 EESPLLPLPEEP-QLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCL 779
Query: 439 -----EPGGGGGGGGP--SPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSR 491
EP GP SP+ EE+ SP+ P S P PE S P + S L +
Sbjct: 780 CAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLS--PVPEEPCLS-PQPEESHLSPQ 836
Query: 492 IEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDV 551
E R + S L+ + E+ + + G + P+ P PPP + +
Sbjct: 837 SEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPG-QCPAPE-ELPLFPPPGEPSLSPL 894
Query: 552 APTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPP 611
GEP + G+ SP +++ +S S P+ +P PP P PPP
Sbjct: 895 L----GEPALSEP-----GEPPLSPLP--EELPLSP-----SGEPSLSPQLMPPDPLPPP 938
Query: 612 PPP------PPYLASL-PLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYD 658
P PP L+ L L YP P P P E P PPP + D
Sbjct: 939 LSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTD 992
Score = 54.3 bits (129), Expect = 1e-06
Identities = 93/358 (25%), Positives = 116/358 (32%), Gaps = 85/358 (23%)
Query: 381 SYPPRRATREEPPGA-----PFAENTAERFPPSYTSYLPPEPSR----PTDQDYRPPASE 431
S PP + PP A PF E+ P PPE SR P D PP E
Sbjct: 582 SPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEE 641
Query: 432 ---APPPE---------------PPE-----PGGGGGGGGPSPEREEVRTSPR--PASPA 466
+PPPE PPE P P PE + P P SP
Sbjct: 642 SPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPP 701
Query: 467 RSGSPA---PETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGA 523
SPA PE + S+P + L E L RS+ L+ EE +
Sbjct: 702 PEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLC-PRSEGPHLSPRPEEPHLSPRPEEPH 760
Query: 524 RDTGSEVP--SGSGHGPC---TPPPAPANFEDVAPTGSGEPGATRESPKANGQNQA---- 574
+E P S PC P + + P S +P SP+ + +
Sbjct: 761 LSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPE 820
Query: 575 SPCSSGDDMEISDDDRGGSPPPAPTPPQ-------QPPPPPPPPPPPP------PYLASL 621
PC S E + P +P P + + PP P P PP P L
Sbjct: 821 EPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEEL 880
Query: 622 PLGYPPHQPAYL----------------------LPPRPDGPP---PPEYPPPPPPPP 654
PL PP +P+ LP P G P P PP P PPP
Sbjct: 881 PLFPPPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPP 938
Score = 50.1 bits (118), Expect = 2e-05
Identities = 77/286 (26%), Positives = 99/286 (34%), Gaps = 41/286 (14%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGG 443
P + ++P G A RFP + +Y PP PS PT +PP A PG G
Sbjct: 2168 PAQVPSQDPFGLAPAYPLEPRFPTAPPTY-PPYPS-PTGAPAQPPMLGASS----RPGAG 2221
Query: 444 GGGGGPSPEREEVRTSP------RPASPARSGSP-APETTNESVPFAQHSSLDSRIEMLL 496
G E T+P +P++P P P N +VP + E LL
Sbjct: 2222 QPG--------EFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLL 2273
Query: 497 KEQRSKFSFLASDTEEEEENSSMV------LGARDTGSEVPSGSGHGPCTPP----PAPA 546
S A + ++EE +S LG D+ S G TP P
Sbjct: 2274 SPPPFGESRKALEVKKEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTP 2333
Query: 547 NFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPP 606
V P G +E P A + P D R GS P QPP
Sbjct: 2334 RASQVEPQSPGLGLRPQEPPPAQALAPSPPSHP-------DIFRPGS---YTDPYAQPPL 2383
Query: 607 PPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPP 652
P P PPPP +LP P P +P P + P P P
Sbjct: 2384 TPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRP 2429
Score = 49.3 bits (116), Expect = 3e-05
Identities = 38/115 (33%), Positives = 49/115 (42%), Gaps = 21/115 (18%)
Query: 1082 REVPVPTPAPVEVPVPERVAGSPV----TPLPEQEASPARPAGPTEESPPSAPL--RPPE 1135
+E P P P P + V+ V P PE+ + P P P+ SPP+ PL P E
Sbjct: 4881 QESPAPEP-PTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTE 4939
Query: 1136 PPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAK 1190
P A PP P+P P SSP P P+ R P E + PP+ K
Sbjct: 4940 PLAEPPVPSPLP--LASSPESARPKPRAR------------PPEEGEDSRPPRLK 4980
Score = 47.0 bits (110), Expect = 2e-04
Identities = 34/108 (31%), Positives = 44/108 (40%), Gaps = 3/108 (2%)
Query: 1075 PSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPP 1134
P + P P TP P + P PE P LP S PA P +S +PL P
Sbjct: 2371 PGSYTDPYAQPPLTPRP-QPPPPESCCALPPRSLPSDPFSRV-PASPQSQSSSQSPLTPR 2428
Query: 1135 EPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP 1182
A P+P R SP P PP + + F+ + P P+PP
Sbjct: 2429 PLSAEAFCPSP-VTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPP 2475
Score = 42.4 bits (98), Expect = 0.004
Identities = 85/357 (23%), Positives = 118/357 (33%), Gaps = 49/357 (13%)
Query: 330 TTAATASSSASSSSLSSSSSSSSSSSSSQ-FRSSDANYPAYYESWNRYQRHTSYP--PRR 386
TT A S+SA + S S + F PA S + + +YP PR
Sbjct: 2130 TTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRF 2189
Query: 387 ATREEPPGAPFAENT-AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEP----- 440
T P P+ T A PP + P +P + PP + P P+P
Sbjct: 2190 PTAP-PTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPR 2248
Query: 441 -----------GGGGGGGGPSPEREEVRTSPRPASPARS---------GSPAPETTNESV 480
G GGG S E SP P +R G+ +P ++
Sbjct: 2249 CPSLDNLAVPESPGVGGGKAS----EPLLSPPPFGESRKALEVKKEELGASSPSYGPPNL 2304
Query: 481 PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT 540
F S + + L + F + + E S LG R E P P +
Sbjct: 2305 GFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRP--QEPPPAQALAP-S 2361
Query: 541 PPPAPANFEDVAPTGS-GEPGATRESPKANGQNQASPCSSGDDMEISDD-DRGGSPPPAP 598
PP P F + T +P T P+ S C+ SD R + P +
Sbjct: 2362 PPSHPDIFRPGSYTDPYAQPPLT---PRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQ 2418
Query: 599 TPPQQPPPPPP-------PPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPP 648
+ Q P P P P P P + + P PP +P P P PP PP
Sbjct: 2419 SSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPP 2475
Score = 41.2 bits (95), Expect = 0.009
Identities = 39/138 (28%), Positives = 56/138 (40%), Gaps = 21/138 (15%)
Query: 1066 EEEERPAALPSASPPPREVPVPTPAP------VEVPVPERVAGSPVTPLPEQEASPARPA 1119
++EE A+ PS PP V +P+ +E+ P+ V +P+TP Q +
Sbjct: 2288 KKEELGASSPSYGPPNLGF-VDSPSSGTHLGGLELKTPD-VFKAPLTPRASQVEPQSPGL 2345
Query: 1120 GPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAP 1179
G + PP A P PP+ P P P + PL P P+ P P
Sbjct: 2346 GLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQP-------------PPP 2392
Query: 1180 EPPPATPPQAKFPGPASR 1197
E A PP++ P SR
Sbjct: 2393 ESCCALPPRSLPSDPFSR 2410
Score = 40.0 bits (92), Expect = 0.019
Identities = 26/88 (29%), Positives = 31/88 (35%), Gaps = 10/88 (11%)
Query: 579 SGDDMEISDDDRGGSPPPAPTPPQQ----------PPPPPPPPPPPPPYLASLPLGYPPH 628
+G E+ R PP P PP P PPP P P + LP
Sbjct: 4271 TGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQL 4330
Query: 629 QPAYLLPPRPDGPPPPEYPPPPPPPPHI 656
LPP G P P+ P PPP +
Sbjct: 4331 PTEAQLPPTHPGTPKPQGPTLEPPPGRV 4358
Score = 38.5 bits (88), Expect = 0.056
Identities = 24/73 (32%), Positives = 27/73 (36%), Gaps = 14/73 (19%)
Query: 596 PAPTPP--------------QQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGP 641
PAP PP +Q PPP P PPP + PP +P LP P
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943
Query: 642 PPPEYPPPPPPPP 654
PP P P P
Sbjct: 4944 PPVPSPLPLASSP 4956
Score = 38.1 bits (87), Expect = 0.074
Identities = 26/90 (28%), Positives = 35/90 (38%), Gaps = 4/90 (4%)
Query: 563 RESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQP--PPPPPPPPPPPPYLAS 620
+ESP Q S + ++++ PP P+PP P P P PP P L +
Sbjct: 4881 QESPAPEPPTQHSYTYNVSNLDVRQ--LSAPPPEEPSPPPSPLAPSPASPPTEPLVELPT 4938
Query: 621 LPLGYPPHQPAYLLPPRPDGPPPPEYPPPP 650
PL PP L P+ P PP
Sbjct: 4939 EPLAEPPVPSPLPLASSPESARPKPRARPP 4968
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 3/73 (4%)
Query: 538 PCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPA 597
P T P ANF AP GSG P + + + A P ++ + +PP
Sbjct: 4563 PLTEPAITANFSLFAPFGSGCPVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPP-- 4620
Query: 598 PTPPQQPPPPPPP 610
TPP PP PPP
Sbjct: 4621 -TPPSSLPPTPPP 4632
Score = 37.0 bits (84), Expect = 0.16
Identities = 29/89 (32%), Positives = 35/89 (39%), Gaps = 12/89 (13%)
Query: 1085 PVPTPAPV-EVPVPERVAGSPVTPLPEQEASPARPAGPTEES-PPSAPLRP------PEP 1136
P P P+ E+ R G P P P S GP + PPS+P P P P
Sbjct: 4267 PGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSP 4326
Query: 1137 PAGPPAPAPRPDERPSSPIP----LLPPP 1161
+ P A P P +P P L PPP
Sbjct: 4327 SSQLPTEAQLPPTHPGTPKPQGPTLEPPP 4355
Score = 36.6 bits (83), Expect = 0.21
Identities = 76/341 (22%), Positives = 118/341 (34%), Gaps = 37/341 (10%)
Query: 1052 SSSSSSSESSSEDEEEEERPAALPSASPPPR----EVPVPTPAPVEVPVPERVAGSPVTP 1107
++S+ SE + D E + L + PP +V + + + P A SP +
Sbjct: 4655 AASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESI 4714
Query: 1108 LPEQEAS-PARPAGPTEESPPS-APLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPK--- 1162
L E+ P +G E+ + +P+ P P A P PD +P + L P K
Sbjct: 4715 LGEEAPRFPHLGSGRWEQEDRALSPVIPLIPRASIPV---FPDTKPYGALGLEVPGKLPV 4771
Query: 1163 ---KRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVK 1219
++ K S + V A S K P E P +
Sbjct: 4772 TTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGT--- 4828
Query: 1220 SWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEA 1279
E +G GG+ + E + + G + A L + L L ++
Sbjct: 4829 ----EPKKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQ--- 4881
Query: 1280 TETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPA----DEV 1335
E+ P P H + L V+ P P EP P P+ L SPA + +
Sbjct: 4882 -----ESPAPEPPTQHSYTYNVSNLDVRQLSAPP---PEEPSPPPSPLAPSPASPPTEPL 4933
Query: 1336 LEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEES 1376
+E P +AE P P L E + EE E+S
Sbjct: 4934 VELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDS 4974
Score = 35.8 bits (81), Expect = 0.37
Identities = 62/256 (24%), Positives = 94/256 (36%), Gaps = 43/256 (16%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGG 443
P A + P +P A E T PP + TD + PP PP PG
Sbjct: 960 PFGAKGDSDPESPLAAPILE------TPISPPPEANCTDPEPVPPMIL-----PPSPGSP 1008
Query: 444 GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNES------VPFAQHSSLDSRIEMLLK 497
G P + P SP S P+ + S +P + S L +++
Sbjct: 1009 VGPASPIL----MEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGV 1064
Query: 498 EQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPC-TPPPAPA--NF----ED 550
++ + ++ E E ++ A S +PS G C P PAPA +F ED
Sbjct: 1065 SDEAELHEMETEKVSEPECPALEPSAT---SPLPSPMGDLSCPAPSPAPALDDFSGLGED 1121
Query: 551 VAPT-GSGEPGATRESPKANG----QNQASPCSSGDD-------MEISDDDRGGSPPPAP 598
AP G PG+ E + G + + SP + ME+ + + + +P
Sbjct: 1122 TAPLDGIDAPGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTPMEVYPECKQTAGQGSP 1181
Query: 599 TPPQQPPPPPPPPPPP 614
Q+ P P P PP
Sbjct: 1182 CEEQEEPRAPVAPTPP 1197
Score = 35.8 bits (81), Expect = 0.37
Identities = 69/269 (25%), Positives = 97/269 (36%), Gaps = 43/269 (15%)
Query: 1071 PAALPSAS-----PPPREVPVP-TPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
PA L +++ PP VP P +P + + +P +V +P Q+ PA P E
Sbjct: 2132 PAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQ----VPSQDPFGLAPAYPLEP 2187
Query: 1125 SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA 1184
P+AP P P+ APA +P +S P P + T PP
Sbjct: 2188 RFPTAPPTYPPYPSPTGAPA-QPPMLGASSRPGAGQPGEFHTT--------------PPG 2232
Query: 1185 TP-PQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEE 1243
TP Q P P + R LD+ ++ PE GG +
Sbjct: 2233 TPRHQPSTPDPFLKP---------RCPSLDNLAV----PESPGVGGGKASEPLLSPPPFG 2279
Query: 1244 EAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYA 1303
E+ EV +L + G P L V+ + E P + L A
Sbjct: 2280 ESRKALEVK---KEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPR-A 2335
Query: 1304 LAVKPTPPAPALRPPEPVPAPAALFSSPA 1332
V+P P LRP EP PA A S P+
Sbjct: 2336 SQVEPQSPGLGLRPQEPPPAQALAPSPPS 2364
Score = 35.8 bits (81), Expect = 0.37
Identities = 97/412 (23%), Positives = 133/412 (32%), Gaps = 64/412 (15%)
Query: 1027 NDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPV 1086
+D S +S S SSS S + S+ + S + P + P + P R+
Sbjct: 2405 SDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFA 2464
Query: 1087 PTPAPVEVPVPERV--AGSPV-TPLPEQEASPARPAGPTEESPPSAP-------LRPPEP 1136
P P PE AGS T L A PAGP E P +R P
Sbjct: 2465 PLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGT 2524
Query: 1137 PAGPPAPAP----------RPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATP 1186
A P+P P +P P P LPPP F + P+ T
Sbjct: 2525 GAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINS--HFGPGPTLGKPQSTNYTV 2582
Query: 1187 PQAKFPGPASRKAPRG--VERTIRNLPLDHASLVKSWPEE-----VSRGGRSRAGGRGRL 1239
F S P + PL S++ + +S G R+G +
Sbjct: 2583 ATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPV 2642
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLE 1299
+ E+ G LA A+L T P + + +E E + +R R LL ++
Sbjct: 2643 EKREDPGTGMGSSLAT-AELPGTQD----PGMSGLSQTEL-EKQRQRQRLRELLIRQQIQ 2696
Query: 1300 HNYALAVKPTPPAPA--LRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQ 1357
N K T A A + PP A SSPA E L + A
Sbjct: 2697 RNTLRQEKETAAAAAGAVGPPGSWGAEP---SSPAFEQLSRGQTPFA------------- 2740
Query: 1358 REEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPP 1409
G +++ S L S S R RPPPP P
Sbjct: 2741 -----------GTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATP 2781
Score = 35.4 bits (80), Expect = 0.48
Identities = 37/149 (24%), Positives = 50/149 (33%), Gaps = 25/149 (16%)
Query: 1078 SPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGP----------TEESPP 1127
+P + P+ A P + P P P Q +P+ P+ P PP
Sbjct: 2323 TPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPP 2382
Query: 1128 SAPLRPPEPP----AGPPAPAP---------RPDERPSSPIPLLPPPKKRRKTVSFSAIE 1174
P P PP A PP P P + SS PL P P
Sbjct: 2383 LTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTP 2442
Query: 1175 VVPAPEP--PPATPPQAKFPGPASRKAPR 1201
+P+P P + PQ++ P K PR
Sbjct: 2443 RFQSPDPYSRPPSRPQSRDPFAPLHKPPR 2471
Score = 35.4 bits (80), Expect = 0.48
Identities = 51/233 (21%), Positives = 81/233 (34%), Gaps = 38/233 (16%)
Query: 446 GGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSF 505
G G P + + P PA+P+ + + S F Q + + + ++Q+
Sbjct: 2762 GPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLW--- 2818
Query: 506 LASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRES 565
+++ ++ R + S P TP P GS G +
Sbjct: 2819 -------QQQQATAATSMRF------AMSARFPSTPGPELGR----QALGSPLAGISTRL 2861
Query: 566 PKANGQNQASPCSSGDDMEISDDDR-----GGSPPPAPTPPQQP---PPPPPPPPPPPPY 617
P G+ P +E+ + + GG+P P PPQ+P P P P
Sbjct: 2862 P-GPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEG 2920
Query: 618 LASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIY--DFVNSLELMDR 668
L L + P P +P PP PE P PH LEL++R
Sbjct: 2921 LRGLAVSGLP-------PQKPSAPPAPELNNSLHPTPHTKGPTLPTGLELVNR 2966
Score = 35.4 bits (80), Expect = 0.48
Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 11/67 (16%)
Query: 593 SPPP---APTPPQQPPPP----PPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPE 645
SPPP AP+P P P P P PP + LPL P P+P PP E
Sbjct: 4915 SPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESAR----PKPRARPPEE 4970
Query: 646 YPPPPPP 652
PP
Sbjct: 4971 GEDSRPP 4977
Score = 35.0 bits (79), Expect = 0.62
Identities = 30/113 (26%), Positives = 43/113 (38%), Gaps = 13/113 (11%)
Query: 1075 PSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPP 1134
P PPR +P P A PV V +P P++ P++ P+ + P A L
Sbjct: 4281 PRPQGPPR-LPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQL--- 4336
Query: 1135 EPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPP 1187
PP P P P+ P L PP R + + + + P PP
Sbjct: 4337 -PPTHPGTPKPQG--------PTLEPPPGRVSPAAAQLADTLFSKGLGPWDPP 4380
Score = 33.5 bits (75), Expect = 1.8
Identities = 23/82 (28%), Positives = 29/82 (35%), Gaps = 5/82 (6%)
Query: 1119 AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPA 1178
AGP + PP P P GP P PSSP KR + + ++
Sbjct: 4279 AGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSP-----QEPKRPSQLPSPSSQLPTE 4333
Query: 1179 PEPPPATPPQAKFPGPASRKAP 1200
+ PP P K GP P
Sbjct: 4334 AQLPPTHPGTPKPQGPTLEPPP 4355
Score = 33.1 bits (74), Expect = 2.4
Identities = 35/119 (29%), Positives = 43/119 (36%), Gaps = 15/119 (12%)
Query: 1070 RPAALPSASPPPREV-------PV-PTPAPVEVPVPERVAG--SPVTPLP-EQEASPARP 1118
RP P PP + PV PTP P P+R + SP + LP E + P P
Sbjct: 4282 RPQGPPRLPAPPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHP 4341
Query: 1119 AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVP 1177
P P P P P PA A D S + PP +T +VP
Sbjct: 4342 GTPK----PQGPTLEPPPGRVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPEQSSLVP 4396
Score = 32.7 bits (73), Expect = 3.1
Identities = 28/87 (32%), Positives = 30/87 (34%), Gaps = 24/87 (27%)
Query: 592 GSPPPA---------PTPPQ----------QPPPPPPPPPPPPPYL-----ASLPLGYPP 627
GSPPPA PT P +PP P P P L +P P
Sbjct: 2114 GSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPS 2173
Query: 628 HQPAYLLPPRPDGPPPPEYPPPPPPPP 654
P L P P P P PP PP P
Sbjct: 2174 QDPFGLAPAYPLEPRFPTAPPTYPPYP 2200
Score = 32.7 bits (73), Expect = 3.1
Identities = 29/78 (37%), Positives = 35/78 (44%), Gaps = 11/78 (14%)
Query: 1060 SSSEDEEEEERPAAL-PSASPPPRE--VPVPTPAPVEVPVPER--VAGSPVTPLPEQEAS 1114
S+ EE P+ L PS + PP E V +PT E PVP +A SP + A
Sbjct: 4907 SAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSP------ESAR 4960
Query: 1115 PARPAGPTEESPPSAPLR 1132
P A P EE S P R
Sbjct: 4961 PKPRARPPEEGEDSRPPR 4978
Score = 32.3 bits (72), Expect = 4.0
Identities = 22/64 (34%), Positives = 24/64 (37%), Gaps = 4/64 (6%)
Query: 593 SPPPAPTPPQQPPPPPPPPPPP--PPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPP 650
S P P P P P PP PPY + P G P P RP P E+ P
Sbjct: 2173 SQDPFGLAPAYPLEPRFPTAPPTYPPYPS--PTGAPAQPPMLGASSRPGAGQPGEFHTTP 2230
Query: 651 PPPP 654
P P
Sbjct: 2231 PGTP 2234
Score = 32.0 bits (71), Expect = 5.3
Identities = 54/237 (22%), Positives = 78/237 (32%), Gaps = 46/237 (19%)
Query: 1023 SDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPR 1082
S G+ S S SE+SS + S S S + + ERP + PP+
Sbjct: 4115 SHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPK 4174
Query: 1083 EVPV-------------PTPAPVEVPVPERVAGSP----VTPLPEQE------------- 1112
PV PT + + +A +P ++P +Q+
Sbjct: 4175 PGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQS 4234
Query: 1113 ----ASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRP------DERPSSPIPLLPPPK 1162
+P T+ SP L G P P P RP P P LP P
Sbjct: 4235 QAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGP-PRLPAPP 4293
Query: 1163 KRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVK 1219
+S + P PPP++P + K P+ +P T LP H K
Sbjct: 4294 ---GALSTGPVLGPVHPTPPPSSPQEPK--RPSQLPSPSSQLPTEAQLPPTHPGTPK 4345
>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
sapiens]
Length = 4911
Score = 129 bits (324), Expect = 2e-29
Identities = 69/143 (48%), Positives = 88/143 (61%), Gaps = 3/143 (2%)
Query: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
K + RSRI GL+A I MVIEY+G IR VA+ +EK Y + G Y+FR
Sbjct: 4770 KSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGV-YMFR 4828
Query: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
+D+D +IDAT G AR+INH C PNC A+V+T E KI+I S + I EE+ YDYKF
Sbjct: 4829 MDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKF 4888
Query: 1687 PLED--NKIPCLCGTESCRGSLN 1707
ED +KIPC CG +CR +N
Sbjct: 4889 DFEDDQHKIPCHCGAVNCRKWMN 4911
Score = 48.1 bits (113), Expect = 7e-05
Identities = 102/470 (21%), Positives = 154/470 (32%), Gaps = 73/470 (15%)
Query: 219 RSSSDTAAYPAGTTAVGTPGNGTPCSQDTS----FSSSRQDTPSSFGQ----FTPQSSQG 270
+S SDT + + PGNG + F+ TP+S PQ+
Sbjct: 1796 QSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPP 1855
Query: 271 TPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDA--------------------FS 310
P SR S A +S S S NS + FS
Sbjct: 1856 PPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFS 1915
Query: 311 RRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYY 370
RR+ +A + T ++++ +++ S + SSS++++ + D P
Sbjct: 1916 RRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMT 1975
Query: 371 ESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPAS 430
+ + + + P E+ P A T++ F P P Q R P S
Sbjct: 1976 DQFPKSLGLSRSP---VVSEQTAKGPIAAGTSDHF-------TKPSPRADVFQRQRIPDS 2025
Query: 431 EAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV-PFAQHSSLD 489
A P P P G G +P P P+S GS + + SV P+ + +
Sbjct: 2026 YARPLLTPAPLDSGPGPFKTP------MQPPPSSQDPYGSVSQASRRLSVDPYERPALTP 2079
Query: 490 SRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFE 549
I+ Q + T N S +R + S G + P + +
Sbjct: 2080 RPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSR-------AFSQPGTISRPTSQDPY- 2131
Query: 550 DVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPP 609
S PG R P + +Q+S + S+ D PP P P P
Sbjct: 2132 ------SQPPGTPR--PVVDSYSQSSGTAR------SNTDPYSQPPGTPRPTTVDPYSQQ 2177
Query: 610 PPPPPPPYLASL---PLGYPPHQPAYLLP---PRPDGPPPPEYPPPPPPP 653
P P P L P+ H Y P PRP P PP P P
Sbjct: 2178 PQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRP 2227
Score = 45.4 bits (106), Expect = 5e-04
Identities = 38/200 (19%), Positives = 80/200 (40%), Gaps = 16/200 (8%)
Query: 954 KHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDS 1013
+ ++ ++D S+ + + E ++E + R++ +K++ ++ + E
Sbjct: 1718 RQQQQDSIDPSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVK 1777
Query: 1014 SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAA 1073
+ + G S S + SS S + + + S ++S ++ ++ P+
Sbjct: 1778 NEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPST 1837
Query: 1074 LPSASPPP----REVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSA 1129
S S + P P PAP +P+ + ++ +A ++P P SP S+
Sbjct: 1838 PTSTSSDDVFVKPQAPPPPPAPSRIPIQDSLS----------QAQTSQPPSPQVFSPGSS 1887
Query: 1130 PLRPPEP--PAGPPAPAPRP 1147
RPP P P PRP
Sbjct: 1888 NSRPPSPMDPYAKMVGTPRP 1907
Score = 38.1 bits (87), Expect = 0.074
Identities = 98/507 (19%), Positives = 159/507 (31%), Gaps = 78/507 (15%)
Query: 187 SYTPQT--VPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCS 244
S+ P + +P G S QG G + T S ++S + PA A + PC
Sbjct: 3514 SFVPDSPSIPVGSPNFSSVKQGHGNLSGT--SFQQSPVRPSFTPALPAAPPVANSSLPCG 3571
Query: 245 QDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENS 304
QD++ + G P S+Q S YS K +R+
Sbjct: 3572 QDSTITH---------GHSYPGSTQ------------SLIQLYSDIIPEEKGKKKRTRKK 3610
Query: 305 YQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDA 364
+D + ++ A +T + I A S + S+ ++S+ S +
Sbjct: 3611 KRDDDAE----STKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGP 3666
Query: 365 NYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFP---PSYTSYLPPEPSRPT 421
+ P + P ++ P +A + ++ P+ T + E +
Sbjct: 3667 STPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETE 3726
Query: 422 DQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVP 481
P E P E G P +PA G E +
Sbjct: 3727 SC----PGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLK 3782
Query: 482 FAQHSSLDSRIEMLLKEQRSKFSFLASD--TEEEE--ENSSMVLGARDTGSEVPSGSGHG 537
+ SSL Q+ + S + D T++ + E + G + G+++ G G G
Sbjct: 3783 NKKSSSL--------LNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCG 3834
Query: 538 ---PCTPPPAPANFEDVAPTG-SGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGS 593
P T + + T +GE A R + + + S D +
Sbjct: 3835 NQLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNL 3894
Query: 594 PPPAPTPPQQPPPPPPPPP--------PPPPYLASLPLGYPPHQPAYLLPPRP------- 638
P PTPP PP PPP LA H+ L P+P
Sbjct: 3895 SNP-PTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRP 3953
Query: 639 ----------DGPPPPEYPPPPPPPPH 655
GP + P P PPH
Sbjct: 3954 QDDLLARALAQGPKTVDVPASLPTPPH 3980
Score = 37.7 bits (86), Expect = 0.096
Identities = 28/123 (22%), Positives = 54/123 (43%), Gaps = 6/123 (4%)
Query: 901 SEISEASEEKRPRPSTPAEEDEDDPE----QEKEAGEPGRPGTKPPKRDEERGKTQGKHR 956
SE ++ E+ +P P P E P ++ G P + G P +R ++ +++GK
Sbjct: 3 SEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTA 62
Query: 957 KSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSK 1016
+G E ++ + + E ++ EED + E VD +K+ E ++S
Sbjct: 63 VEDEDSMDGLETTETETIVETEIKEQSAEEDAEAE--VDNSKQLIPTLQRSVSEESANSL 120
Query: 1017 CSL 1019
S+
Sbjct: 121 VSV 123
Score = 37.7 bits (86), Expect = 0.096
Identities = 46/200 (23%), Positives = 66/200 (33%), Gaps = 60/200 (30%)
Query: 484 QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGAR----DTGSEVPSGSGHGPC 539
Q S ++IE K ++ K E+++ G++ +GS+ PS P
Sbjct: 1759 QKSKQQAKIEATQKLEQVK--------NEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPL 1810
Query: 540 TPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCS-SGDDMEISDDDRGGSPPPAP 598
TP P N P + Q ++P S S DD+ +
Sbjct: 1811 TPQPGNGNMS---------PAQSFHKELFTKQPPSTPTSTSSDDVFVK------------ 1849
Query: 599 TPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRP---------DGPPPPEYP-- 647
P PPPPP + +P+ Q PP P PP P P
Sbjct: 1850 ----------PQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYA 1899
Query: 648 -----PPPPPPPHIYDFVNS 662
P PPP H + NS
Sbjct: 1900 KMVGTPRPPPVGHSFSRRNS 1919
Score = 37.4 bits (85), Expect = 0.13
Identities = 36/151 (23%), Positives = 58/151 (38%), Gaps = 7/151 (4%)
Query: 942 PKRDEERGKT---QGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTK 998
PK+ E+ KT KH E ++ S E E E++++ ++ VDT
Sbjct: 2794 PKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVESKCETEKNDENKDNVDTPC 2853
Query: 999 KETEV-SDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSS 1057
+ SD D E S C N T+ ++ +S+ + +S +
Sbjct: 2854 SQASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITG 2913
Query: 1058 SE---SSSEDEEEEERPAALPSASPPPREVP 1085
S SS E+ + PS SPPP +P
Sbjct: 2914 STPVLSSLLANEKSDNSDIRPSGSPPPPTLP 2944
Score = 36.6 bits (83), Expect = 0.21
Identities = 77/383 (20%), Positives = 134/383 (34%), Gaps = 43/383 (11%)
Query: 968 ASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGEN 1027
+SQE + + D ++ + + + K + D D S S+ L+ D +
Sbjct: 1686 SSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSE--LFKDPLKQR 1743
Query: 1028 DSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAA-----LPSASPPPR 1082
+S + E S + ++ + +E ++++++ + S S P
Sbjct: 1744 ESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSDTPS 1803
Query: 1083 EVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPA 1142
+ +P P P SP ++ + P+ PT S ++P PP PPA
Sbjct: 1804 S-GIQSPL---TPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPP-PPA 1858
Query: 1143 PAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRG 1202
P+ P + S PP + + S PP P AK G R P G
Sbjct: 1859 PSRIPIQDSLSQAQTSQPPSPQVFSPGSS------NSRPPSPMDPYAKMVG-TPRPPPVG 1911
Query: 1203 VERTIRN--LPLDHASLVKSWPEEV-------SRGGRSRAGGRGRLTEEEEAEPGTEVDL 1253
+ RN P+++ + + S + +R R T + +
Sbjct: 1912 HSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPR 1971
Query: 1254 AVLADLALTPARRGLPALPAVEDSE-----ATETSDEAERPRP---LLSHILLEHNYAL- 1304
V+ D P GL P V + A TSD +P P + + +YA
Sbjct: 1972 PVMTD--QFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARP 2029
Query: 1305 AVKPTP----PAPALRPPEPVPA 1323
+ P P P P P +P P+
Sbjct: 2030 LLTPAPLDSGPGPFKTPMQPPPS 2052
Score = 36.2 bits (82), Expect = 0.28
Identities = 32/109 (29%), Positives = 42/109 (38%), Gaps = 21/109 (19%)
Query: 1071 PAALPSASPPPREVPVPTPAPVEVP----VPERVAGSPVTPLPEQEASPARPAGPTEESP 1126
P +PS P P +P TP + P VP+++ T + SP R P
Sbjct: 3278 PTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQP 3337
Query: 1127 PSA----PLRPP--EPPAG-------PPAPAPRPDERPSSPIPLLPPPK 1162
SA PL PP +PP PAP + P S PPP+
Sbjct: 3338 NSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSG----PPPR 3382
Score = 35.0 bits (79), Expect = 0.62
Identities = 28/112 (25%), Positives = 48/112 (42%), Gaps = 20/112 (17%)
Query: 421 TDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRP----ASPARSGSPAPET- 475
+++D + PPP P EP G PSP + R RP ASP + P +
Sbjct: 3 SEEDKSVEQPQPPPPPPEEP----GAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSR 58
Query: 476 ------TNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVL 521
+S+ + + ++ +E +KEQ ++ D E E +NS ++
Sbjct: 59 GKTAVEDEDSMDGLETTETETIVETEIKEQSAE-----EDAEAEVDNSKQLI 105
Score = 34.3 bits (77), Expect = 1.1
Identities = 39/179 (21%), Positives = 70/179 (39%), Gaps = 16/179 (8%)
Query: 998 KKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSS 1057
KK T ++ + E +SK +++ +ND D+ + S +S+ S + +S
Sbjct: 2814 KKSTVTNEVKTEVLSPNSKVESKCETE-KNDENKDNVDTPCSQASAHSDLNDGEKTSLHP 2872
Query: 1058 SESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPAR 1117
+ E+ R A PSA+ A ++P + + +T ++P
Sbjct: 2873 CDPDLF-EKRTNRETAGPSANV--------IQASTQLPAQDVINSCGITG-----STPVL 2918
Query: 1118 PAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVV 1176
+ E ++ +RP P P PA P SS P + PP + S + VV
Sbjct: 2919 SSLLANEKSDNSDIRPSGSPPPPTLPA-SPSNHVSSLPPFIAPPGRVLDNAMNSNVTVV 2976
Score = 33.5 bits (75), Expect = 1.8
Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 7/162 (4%)
Query: 989 DREEAVDTTKKETEVSDG--EDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSS 1046
+R + K+ +E+S G + E + + C G SE+ SS SSS+ S
Sbjct: 718 ERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADIS 777
Query: 1047 SSSSSSSSSSSSESSSEDEEEEERPAALPSAS---PPPREVPVPTPAPVEVPVPERVAGS 1103
+ SSS + SS+ S D P+AL S++ P + V + P + S
Sbjct: 778 KADVSSSPTPSSDLPSHD-MLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFS 836
Query: 1104 PVTPLPEQEA-SPARPAGPTEESPPSAPLRPPEPPAGPPAPA 1144
P P +Q A S P SP + R P P A
Sbjct: 837 PGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSA 878
Score = 33.1 bits (74), Expect = 2.4
Identities = 90/420 (21%), Positives = 131/420 (31%), Gaps = 56/420 (13%)
Query: 248 SFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFK-----PRRSE 302
+FS ++ + P S TP + + + S +SQ S T+ + PR
Sbjct: 2084 NFSHNQSNDPYSQPPLTPHPAVNESF-AHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVV 2142
Query: 303 NSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSS 362
+SY + + S T TT S + S+ + + ++Q S
Sbjct: 2143 DSYSQSSGTARSNTDPYSQPPGTP-RPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSD 2201
Query: 363 DANYPAYYESWNRYQRHTSYPPRRATREEPPGAP-------FAENTAER--FPPSYTSYL 413
+P T P +PP P F ++ R P+ +L
Sbjct: 2202 PYAHPP----------GTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQDPFL 2251
Query: 414 PPEPSRPTDQD---YRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGS 470
+R RPP + + P PP PG SP P +P RS S
Sbjct: 2252 QAAQNRGPALPGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTP-RSQS 2310
Query: 471 PAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEV 530
+ T+ + H D S+ SF AS G V
Sbjct: 2311 DSFGTSQTA-----HDVADQ------PRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPV 2359
Query: 531 P-SGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDD 589
P SG T A A+ E + R+ + Q E D
Sbjct: 2360 PTSGVTDTQNTVNMAQADTEKLRQ---------RQKLREIILQQQQQKKIAGRQEKGSQD 2410
Query: 590 RGGSPPPAPTPPQQPPPPPPP---PPPPPPYLASLPLGYPPHQPAYLLPPRPD-GPPPPE 645
P P P QP PPPP P P+ PP P Y + P+ GP PP+
Sbjct: 2411 SPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVA-PPLGPRYAVFPKDQRGPYPPD 2469
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 105 bits (262), Expect = 4e-22
Identities = 143/593 (24%), Positives = 233/593 (39%), Gaps = 82/593 (13%)
Query: 866 WAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDP 925
+AK+ G T +A A + L S KV ++ +++ + + S+ ED +
Sbjct: 34 FAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEE 93
Query: 926 EQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDE 985
E+E + G P + P KR G GK A + +S+ESS + DEED ++
Sbjct: 94 EEEVQ-GPPAKKAAVPAKRV---GLPPGKA----AAKASESSSSEESSDDDDEEDQKKQP 145
Query: 986 EDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDS------TSDSESSSSS 1039
+ + K + + D +SDSSS+ D +N T +++ +
Sbjct: 146 VQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE-----DEPPKNQKPKITPVTVKAQTKAPP 200
Query: 1040 SSSSSS---SSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPV 1096
+ ++ ++ ++SSSSSSS SSS D+ EEE+ AA P + P ++V P
Sbjct: 201 KPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKA-ATT 259
Query: 1097 PERVAGSPVTPLPEQEASPARP----AGP-TEESPPSAPLRPPEPPAG--PPAPA----- 1144
P R + S ++E +P GP + PPSAP PP+ G PP A
Sbjct: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP--PPKKSLGTQPPKKAVEKQQ 317
Query: 1145 ------PRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198
DE SS PP K VS + + PA + ++ + +
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTK--AVVSKATTKPPPAKKAAESSSDSSDSDSSEDDE 375
Query: 1199 APRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRL--------TEEEEA----E 1246
AP T +N A KS + + + GG +L + EEE+ E
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435
Query: 1247 PGTEVDLAVLADLALTPARRGLPALPAVE-------DSEATETSDEAERPRPLLSHILLE 1299
T+ +A A A LPA A + DS+++ + +E E+
Sbjct: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEK----------T 485
Query: 1300 HNYALAVKPTPPAPALRPPEPVPA----PAALFSSPADEVLEAPEVVVAEAEEPKPQQLQ 1355
A+ KP A P +P A + SS +D+ E E + P+PQ +
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
Query: 1356 QQREEG----EEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPP 1404
+ + EEEEEE ++ G+L++R A+ P
Sbjct: 546 ANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETP 598
Score = 55.5 bits (132), Expect = 4e-07
Identities = 72/380 (18%), Positives = 127/380 (33%), Gaps = 12/380 (3%)
Query: 198 KALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPC-SQDTSFSSSRQDT 256
K K Q +G + A+ + SS + G P ++ +
Sbjct: 62 KVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121
Query: 257 PSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSA 316
+S + +SS + P + + K +S +S D+ S
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
Query: 317 SSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRY 376
+ + A T A + ++ +++ ++SSSSSSS SSD + E
Sbjct: 182 NQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDS----EEEKAAA 237
Query: 377 QRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRP-PASEAPPP 435
+ P ++ + P A A + S S E + +P P S PPP
Sbjct: 238 TPKKTVPKKQVVAKAPVKA--ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPP 295
Query: 436 EPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEML 495
P P G P E+ + + + E + A S ++
Sbjct: 296 SAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
Query: 496 LKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTG 555
K S SD+ E++E S G S P+ + P P A P G
Sbjct: 356 KKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK----QPVG 411
Query: 556 SGEPGATRESPKANGQNQAS 575
G+ TR++ ++ + ++S
Sbjct: 412 GGQKLLTRKADSSSSEEESS 431
Score = 48.5 bits (114), Expect = 5e-05
Identities = 83/396 (20%), Positives = 149/396 (37%), Gaps = 52/396 (13%)
Query: 753 PMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNR 812
P+ A P+ S E EE + K P G V K + +
Sbjct: 253 PVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKP--GPYSSVPPPSAPPPKKSLGTQPPK 310
Query: 813 KMVENV-----AFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWA 867
K VE + + D+ S EE+ KP A +A + K E S D +
Sbjct: 311 KAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAE----SSSDSS 366
Query: 868 KSGGTTGIEAFAFGSGL-RGALRLPSFKVKRKEPSEISEASEEKRP---------RPSTP 917
S + EA + +G + + P+ V K P+ + A+ K+P R +
Sbjct: 367 DSDSSEDDEAPSKPAGTTKNSSNKPA--VTTKSPA-VKPAAAPKQPVGGGQKLLTRKADS 423
Query: 918 AEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKD 977
+ +E+ E+E + TKP + K + DS + +SSS ++
Sbjct: 424 SSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDS---DSSSSEE 480
Query: 978 EEDDEEDEEDEDREEAV---DTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSE 1034
EE+ + + + V K G+ E S+SSS DS E + +
Sbjct: 481 EEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSS----DDSSEEEEEKLKGK 536
Query: 1035 SSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSAS---------PPPREVP 1085
S + ++ +S+ ++ + ++++S E+EEE+++ A + S S +E
Sbjct: 537 GSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE 596
Query: 1086 VPTPAPVEVPVP---------ERVAGSPVTPLPEQE 1112
P +++ P E+ A SP + E+E
Sbjct: 597 TPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEE 632
Score = 38.9 bits (89), Expect = 0.043
Identities = 54/259 (20%), Positives = 97/259 (37%), Gaps = 34/259 (13%)
Query: 1159 PPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLV 1218
P KK +K S S E E PP K PA R LP A+
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVG----------LPPGKAAA- 121
Query: 1219 KSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSE 1278
+ S S E+++ +P + + A A P ++ A + DS+
Sbjct: 122 -----KASESSSSEESSDDDDEEDQKKQP-VQKGVKPQAKAAKAPPKK---AKSSDSDSD 172
Query: 1279 ATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEA 1338
++ + + +P ++ + ++ A PP PA P+ AA SS + +
Sbjct: 173 SSSEDEPPKNQKPKITPVTVK-----AQTKAPPKPARAAPKIANGKAASSSSSSSSSSSS 227
Query: 1339 PEVVVAEAEEPK----PQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSL 1394
+ +EE K P++ +++ + + +SS S SS E +++ +
Sbjct: 228 DD-----SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPM 282
Query: 1395 RSHARRRRPPPPPPPPPPR 1413
++ PPP PPP+
Sbjct: 283 KNKPGPYSSVPPPSAPPPK 301
Score = 35.8 bits (81), Expect = 0.37
Identities = 53/291 (18%), Positives = 97/291 (33%), Gaps = 22/291 (7%)
Query: 202 EKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQD--TPSS 259
E + S ++++ + A TT S D+S S S +D PS
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 260 FGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSA 319
T SS T++ + R++++S + S +
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 320 STTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRH 379
A+T AT A S A + S SSS S SSS S ++
Sbjct: 440 KMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS--------------SEEEEEKT 485
Query: 380 TSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPE 439
+ ++ ++ GA ++ + + + +S +++ + +P P+ P+
Sbjct: 486 SKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPK 545
Query: 440 PGG------GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQ 484
G G + E EE ++SGS NE+ A+
Sbjct: 546 ANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAE 596
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 104 bits (259), Expect = 8e-22
Identities = 155/679 (22%), Positives = 244/679 (35%), Gaps = 136/679 (20%)
Query: 829 SKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGA- 887
S +E P Q+ A A + + S + G G+E + LRG
Sbjct: 837 SGKEAKGPLQDGATTDANG--------RANAVASSTERTPGSGVNGLEEPSIAKRLRGTP 888
Query: 888 --LRLPSFKVKRKEPSEISEASEEKRPRPS------TPAEEDEDDPEQEKEAGEPGRPGT 939
+ L ++++ ++ + E EE + + T AEED E E E G
Sbjct: 889 ERIELENYRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEEGEEEE 948
Query: 940 KPPKRDEE-----------------RGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDE 982
+ P+ +GK++ + S + EE +E ++EE+++
Sbjct: 949 EEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEED 1008
Query: 983 EDEEDEDREEAVDTTKKE----------------TEVSDGEDEE-----SDSSSKCSLYA 1021
DEE+E+ EA + ++ T + + E+EE S+SS+ +
Sbjct: 1009 YDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGAPLD 1068
Query: 1022 DSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPP 1081
++D E D DSE + ++ + + + S+ + +R LP
Sbjct: 1069 ENDLEEDV--DSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPC----- 1121
Query: 1082 REVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSA----PLRPP--E 1135
P A +E+ V E P +P QE P++ P SA P+ P E
Sbjct: 1122 ---PAEGEAELELRVSEDEEKLPASP-KHQERGPSQATSPIRSPQESALLFIPVHSPSTE 1177
Query: 1136 PPAGPPAPAPRPDERPSS---PIPLLPPPKKRRKTVSFSAIEVVPAP-EPPPATPPQAKF 1191
P PP PA ++ P P PLLP K++ K + S ++ V +P P T P+A+
Sbjct: 1178 GPQLPPVPAATQEKSPEERLFPEPLLP--KEKPKADAPSDLKAVHSPIRSQPVTLPEART 1235
Query: 1192 PGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEV 1251
P P+ P AS P + + +P TE
Sbjct: 1236 PVSPGSPQPQ---------PPVAASTPPPSPLPIC----------------SQPQPSTEA 1270
Query: 1252 DLAVLADLAL----TPARRGLPALPAVEDSEATETS--------DEAERPRPLLSHILL- 1298
+ + PA+ P P S++ DEA R L+ +
Sbjct: 1271 TVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMK 1330
Query: 1299 --EHNYALAVKPTPPAPALRPPEPVPA--PAALFS-----SPADE------VLEAPEVVV 1343
E +L + P + P P PA P +L S SP DE L P+ +
Sbjct: 1331 SAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLG 1390
Query: 1344 AEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS----SSSDGEGALRRRSLR-SHA 1398
E +P L R + E EE E SS S SS L +S S +
Sbjct: 1391 LPKPEGEPLSLPTPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDS 1450
Query: 1399 RRRRPPPPPPPPPPRAYEP 1417
PP PPPPPP EP
Sbjct: 1451 AMLTPPSSPPPPPPPGEEP 1469
Score = 51.6 bits (122), Expect = 6e-06
Identities = 144/650 (22%), Positives = 204/650 (31%), Gaps = 125/650 (19%)
Query: 414 PPEPSRPTDQDYRPPASEAPPPEP----PEPGGGGGGGGPSPEREEVRTSPRPASPARSG 469
P P P Q P A+ PPP P +P PSP + +R P PA +
Sbjct: 1236 PVSPGSPQPQP--PVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKTSTPL 1293
Query: 470 SPAPETTNESV------PFA-----QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSS 518
+P P + P A + S L M E R D + E S
Sbjct: 1294 APLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIRRSLGLTPVDRSKGPEPSF 1353
Query: 519 MVLGARDTG------SEVPSGSGHGPCTPPPAPANFEDVAPTGSGEP--------GATRE 564
R + P G P P P GEP + RE
Sbjct: 1354 PTPAFRPVSLKSYSVEKSPQDEGLHLLKPLSIPKRLG--LPKPEGEPLSLPTPRSPSDRE 1411
Query: 565 SPKANGQNQASPCSSGDDMEISDDDR--------GGSPPPAPTPPQQPPPPPPPPPPPPP 616
A + + SSG + S + S TPP PPPPPPP P
Sbjct: 1412 LRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPPGEEPAT 1471
Query: 617 YLASLPLGYPPHQPAYLLPPRP-DGPPPPEYPPPPPPPPHIYDFVNSLE---LMDRLGAQ 672
L P + + PP P PP P PP FV S+E D +
Sbjct: 1472 LRRKLREAEP--NASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDT 1529
Query: 673 WGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYAL 732
+ +Q + T P + P PP G AL
Sbjct: 1530 YDDKTEDSSLQEKFFT------------------PPSCWPRPEKPRHPPLAKENGRLPAL 1571
Query: 733 YAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVG 792
G + LP+ A E ELAE +
Sbjct: 1572 -------EGTLQPQKRGLPLVSA-------------------EAKELAEERMR------A 1599
Query: 793 RVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEK 852
R ++ Q ++ M R L+R +A GA + KA + K++ +
Sbjct: 1600 REKSVKSQALRDAMARQLSRMQQMELASGA------PRPRKASSAPSQGKERRPDSPTRP 1653
Query: 853 T--KLKEPGLLS-------LVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEI 903
T +EP L L + SGG G + GS + R F +R + +
Sbjct: 1654 TLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFSPRRNKKEKK 1713
Query: 904 SEASEEKRPRPSTP-AEEDEDDPEQEKEAGEPGRPGTKPPKRDEE-------RGKT--QG 953
S+ +PS+ EE P+ ++ G K K D++ G T G
Sbjct: 1714 SKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSG 1773
Query: 954 KHRKSFALDSEGEEASQESSSEKDE---EDDEEDEEDEDREEAVDTTKKE 1000
KHR + +E + Q S SE + +D E + R E T++E
Sbjct: 1774 KHRVLPVVRAELQLRRQLSFSEDSDLSSDDVLEKSSQKSRREPRTYTEEE 1823
Score = 47.4 bits (111), Expect = 1e-04
Identities = 158/750 (21%), Positives = 234/750 (31%), Gaps = 125/750 (16%)
Query: 386 RATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGG 445
R EE AP +E++A P E D D P E E +PG G
Sbjct: 1046 REREEEERMAPASESSASGAPLD-------ENDLEEDVDSEPAEIEGEAAEDGDPGDTGA 1098
Query: 446 --------GGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLK 497
PS E+R P PA E +P + K
Sbjct: 1099 ELDDDQHWSDSPSDADRELRL-PCPAEGEAELELRVSEDEEKLPASP------------K 1145
Query: 498 EQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGS- 556
Q S S +E++ + + +E P PP PA ++ +P
Sbjct: 1146 HQERGPSQATSPIRSPQESALLFIPVHSPSTEGPQ--------LPPVPAATQEKSPEERL 1197
Query: 557 -GEPGATRESPKANGQNQA----SPCSSGDDM--EISDDDRGGSPPPAPTPPQQPPPPPP 609
EP +E PKA+ + SP S E GSP P P PPP P
Sbjct: 1198 FPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSP 1257
Query: 610 PP---PPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELM 666
P P P A++P P Q P P P P P D + S +
Sbjct: 1258 LPICSQPQPSTEATVP---SPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAV 1314
Query: 667 DRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL--IAASAGPPGGAFGEAFLPFPPPQEA 724
D + + F M++ ++R+ GL + S GP FP P
Sbjct: 1315 DE-ALRRSDLVEEFWMKSA------EIRRSLGLTPVDRSKGPEPS--------FPTPAFR 1359
Query: 725 AYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKT 784
L + + G + + +P + +S R P E A+ +
Sbjct: 1360 PVSLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEER 1419
Query: 785 LPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQ 844
+ + G L MK++ + N + A S P + A +
Sbjct: 1420 RELSSSSGLGLHGSSSNMKTLGSQSFN------TSDSAMLTPPSSPPPPPPPGEEPATLR 1473
Query: 845 AKEEDKEKTKLKEPGLLSLV-------------DWAKSGGTTGIEAFAFGSGLRGALRLP 891
K + E P L + + +E F +
Sbjct: 1474 RKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDTY--- 1530
Query: 892 SFKVKRKEPSEISEASEEKRPRPST-PAEEDEDDPEQEKEAGE-PGRPGTKPPKRD---- 945
+ +E S E+ PS P E P KE G P GT P++
Sbjct: 1531 ------DDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRGLPL 1584
Query: 946 ---------EERGKTQGKHRKSFAL-DSEGEEASQ----ESSSEKDEEDDEEDEEDEDRE 991
EER + + K KS AL D+ + S+ E +S + +E
Sbjct: 1585 VSAEAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASSAPSQGKE 1644
Query: 992 EAVDTTKKETEVSDGED---EESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSS 1048
D+ + T E E+ S S +DS G + S + SE SS S SS S
Sbjct: 1645 RRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLFS 1704
Query: 1049 SSSSSSSSSSESSSEDEEEEERPAALPSAS 1078
+ S+ E RP PS++
Sbjct: 1705 PRRNKKEKKSKG-------EGRPPEKPSSN 1727
Score = 40.0 bits (92), Expect = 0.019
Identities = 33/116 (28%), Positives = 43/116 (37%), Gaps = 19/116 (16%)
Query: 1029 STSDSESSSSSSSSSSSSSSSS---SSSSSSSSESSSEDEEEEERPAALPSASPPPREVP 1085
S SD E S+ SSSS SSS+ S+ + P +SPPP P
Sbjct: 1406 SPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPPP 1465
Query: 1086 VPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPP 1141
PA + + E + V P P P+ +RPP PA PP
Sbjct: 1466 GEEPATLRRKLREAEPNASVVPPP----------------LPATWMRPPREPAQPP 1505
Score = 37.0 bits (84), Expect = 0.16
Identities = 77/389 (19%), Positives = 120/389 (30%), Gaps = 62/389 (15%)
Query: 1055 SSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEAS 1114
S S S + ++E P + P +P P P+ +P P + + E+
Sbjct: 1362 SLKSYSVEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLPTPRSPSDRELRSAQEERRE 1421
Query: 1115 PARPAG---------------PTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLP 1159
+ +G + + SA L PP P PP P E P++
Sbjct: 1422 LSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPPPP----PGEEPAT------ 1471
Query: 1160 PPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPL------- 1212
+R+ + VVP P P P + P + + ++ +P
Sbjct: 1472 --LRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSFVESVEEIPFADDVEDT 1529
Query: 1213 -----DHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRG 1267
+ +SL + + S R L +E P E L P +RG
Sbjct: 1530 YDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEG--------TLQPQKRG 1581
Query: 1268 LPALPAVEDSEATETSDEAERPR--PLLSHIL-------LEHNYALAVKPTPPAPALRPP 1318
LP + A EA E ++E R R + S L L + + P P
Sbjct: 1582 LPLVSA----EAKELAEERMRAREKSVKSQALRDAMARQLSRMQQMELASGAPRPRKASS 1637
Query: 1319 EPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD 1378
P SP L E + E + L + G +G E S
Sbjct: 1638 APSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDG--SFTSSEGSSGK 1695
Query: 1379 SSSSSDGEGALRRRSLRSHARRRRPPPPP 1407
S S R + + RPP P
Sbjct: 1696 SKKRSSLFSPRRNKKEKKSKGEGRPPEKP 1724
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 102 bits (254), Expect = 3e-21
Identities = 236/1075 (21%), Positives = 351/1075 (32%), Gaps = 215/1075 (20%)
Query: 416 EPSRPTDQDYRPPASEAPP-----------PEPPEPGGGGGGGGPSPEREEVRTSPRPAS 464
EP+ P+ + RP S PP P PP PG G G P+ E ++ PA
Sbjct: 860 EPAAPSPR-LRPEESLDPPGAMQELLGALEPLPPAPGDTGVGP-PNSEGKD------PAG 911
Query: 465 PARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGAR 524
RS SP VP DS +L E+RS F T EE
Sbjct: 912 AYRSPSPQGTKAPRFVPLTSICFPDS---LLQDEERSFFP-----TMEEMFGGGAADDYG 963
Query: 525 DTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEP-GATRESPKANGQNQASPCSSGDDM 583
G G PPP P ++ P G GA E+P P
Sbjct: 964 KAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPP------- 1016
Query: 584 EISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLG------YPPHQPAYLLPP- 636
E+ + P Q PPPPPPPPPPP AS P G + +P LL
Sbjct: 1017 ELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTS 1076
Query: 637 -----RPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLH 691
R PP + P Y+F + D +P ++ + L L
Sbjct: 1077 SFHLLRRRDPP---FQTPKKLYAQEYEFEADEDKAD--------VPADIRLNPRRLPDL- 1124
Query: 692 QLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLP 751
+ + + P G+ + F PP G + GR + P
Sbjct: 1125 -------VSSCRSRPALSPLGD--IDFCPPNPGPDG-------PRRRGRKPTKAKRDGPP 1168
Query: 752 MPMA---AEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQR 808
P PL + +G + P + A+ G+ ++ +K + +
Sbjct: 1169 RPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIK 1228
Query: 809 DLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQA--KEEDKEKTKLKEPGLLSLVDW 866
K E + + D + K +A KE ++++ ++K + S +D+
Sbjct: 1229 LSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDF 1288
Query: 867 AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPE 926
KSG + +GL L P K PS PA + P
Sbjct: 1289 LKSGKR---HPPLYQAGLTPPLSPP------------------KSVPPSVPARGLQPQP- 1326
Query: 927 QEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEE 986
P P P G AL++ E + DEE +
Sbjct: 1327 -------PATPAVPHP-------PPSGAFGLGGALEAAESEGLGLGCPSPCKRLDEELKR 1372
Query: 987 DEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSS 1046
+ + + + ++++ + + +ES SS+ +L TS + + +++
Sbjct: 1373 NLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPG 1432
Query: 1047 SSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVT 1106
S++S + E EE+P P +P P+ P P P P + +P
Sbjct: 1433 PPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALP--------- 1483
Query: 1107 PLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRK 1166
SP PT SPP PL PP PPA P P P P + PL PP++
Sbjct: 1484 -------SPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPP----PPPAAAPLAAPPEE--- 1529
Query: 1167 TVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVS 1226
P+PE P + P ++K + A++ EE
Sbjct: 1530 -------PAAPSPEDPELPDTR---PLHLAKKQ-------------ETAAVCGETDEEA- 1565
Query: 1227 RGGRSRAGGRGRLTEEEE----AEPGTEVDLAVLADLALTPARRGLPAL-----PAVEDS 1277
+GG G E +E AE + LA+ P R AL P ++D
Sbjct: 1566 ----GESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEIKDG 1621
Query: 1278 E----ATET-----SDEAERPRPLLSHILLEHN-----YALAVKP--TPPAPALR----- 1316
+ AT D R + L L N A KP PP P R
Sbjct: 1622 QRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSGQAK 1681
Query: 1317 ----------PPEPVPAPAALFSSPADEVLE-----APEVVVAEAEEP-KPQQLQQQREE 1360
PP PAP +P E PE + E P KP L+ +E
Sbjct: 1682 NPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKE 1741
Query: 1361 GEEEGEEEGEE--EEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPR 1413
E+E GE E ++ + + S + RP PPP+
Sbjct: 1742 KEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPK 1796
Score = 96.7 bits (239), Expect = 2e-19
Identities = 83/267 (31%), Positives = 105/267 (39%), Gaps = 53/267 (19%)
Query: 401 TAERFPPSYTSYLPPEPSRPTDQ---------DYRPPASEAPPPEPPEPGGGGGGGGPSP 451
+ +R PP Y + L P S P +PPA+ A P PP G GG +
Sbjct: 1291 SGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAA 1350
Query: 452 EREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTE 511
E E + G P+P + L +E L + +A + +
Sbjct: 1351 ESEGLGL----------GCPSPCKRLDE-------ELKRNLETLPSFSSDEEDSVAKNRD 1393
Query: 512 EEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQ 571
+E SS + D P + P PP APA P PG P AN
Sbjct: 1394 LQESISSAISALDDPPLAGPKDTST-PDGPPLAPAA---AVPGPPPLPGL----PSANSN 1445
Query: 572 NQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPP----PPPPPYLASLPLGYPP 627
P + ++ +PPPAPTP QPPPPPPPP P PPP +A P PP
Sbjct: 1446 GTPEP-------PLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPP 1498
Query: 628 HQPAYLLPPRPDGPPPPEYPPPPPPPP 654
PP P PPPP P PPPPPP
Sbjct: 1499 -------PPLPP-PPPPAMPSPPPPPP 1517
Score = 86.7 bits (213), Expect = 2e-16
Identities = 242/1100 (22%), Positives = 336/1100 (30%), Gaps = 211/1100 (19%)
Query: 393 PGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPE 452
PG P AE T + P P R + D A G GG GG P
Sbjct: 628 PGGPPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGTP 687
Query: 453 REEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512
E + P+ R + T+ S+ ++L+ + L +++ K +T E
Sbjct: 688 YELAKEDPQ-----RYHLQSVIRTSASLDEGATAALELGLGRL--KEKKKGPERGGETPE 740
Query: 513 EEENSSMVLGA--RDTGSEVPSGSGHGPCTPPPAPANFEDVAPTG------SGEPGATRE 564
S + GA ++ G+ + +PPP P + PT +G P
Sbjct: 741 GLATSVVHYGAGAKELGAFLQK-------SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLV 793
Query: 565 SPKANGQNQASPCSSGDDMEISDDDRGGS--PPPAPTPPQQPPPPPPPPPPPPPYLASLP 622
P Q S S S G P QPPPPPPPPPPP P
Sbjct: 794 LPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAH 853
Query: 623 L---GYPPHQPAYLLPPRPDGPPP-------PEYPPPPPPPPHIYDFVNSLELMDRLGAQ 672
L G P P+ L P PP P PP P + E D GA
Sbjct: 854 LRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAY 913
Query: 673 WGGMPMSFQ----------------MQTQMLTRLHQLRQGKGLIAA----SAGPPGGAFG 712
P + +Q + + + + G AA AGPP
Sbjct: 914 RSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGD 973
Query: 713 EAFLPFPPPQEAAYGLPYALYAQGQ--------EGRGAYSREAYHLPMPMAAEPLPSSSV 764
PPP AY PY Y G+ G G + LP + AEPL
Sbjct: 974 PKAGAGPPPGPPAYD-PYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQS 1032
Query: 765 SGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFD 824
+A PP P + G + + + K +K+++ +F
Sbjct: 1033 GPHQAAPPPPPP---PPPPPAPASEPKGGLTSPIFCSTKP-------KKLLKTSSFHLL- 1081
Query: 825 QWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGL 884
+ PFQ K A+E + E D K+ I
Sbjct: 1082 ------RRRDPPFQTPKKLYAQEYEFE------------ADEDKADVPADI--------- 1114
Query: 885 RGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKR 944
R P + + R RP+ D D P R G KP K
Sbjct: 1115 ------------RLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKA 1162
Query: 945 DEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVS 1004
+ G + + R A S+S + + R ++ E +
Sbjct: 1163 KRD-GPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGR-------GRKAEEA 1214
Query: 1005 DGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSED 1064
G E K L GE TS ++ S + +S SS + + E +
Sbjct: 1215 GGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVEEKQ 1274
Query: 1065 EEEEE-------------------RPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPV 1105
E + A L PP+ VP PA P P P
Sbjct: 1275 PEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQP------PA 1328
Query: 1106 TP-LPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLP----- 1159
TP +P S A G E+ S L G P+P R DE + LP
Sbjct: 1329 TPAVPHPPPSGAFGLGGALEAAESEGL-----GLGCPSPCKRLDEELKRNLETLPSFSSD 1383
Query: 1160 --PPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASL 1217
+ + + S + A + PP GP P G PL A+
Sbjct: 1384 EEDSVAKNRDLQESISSAISALDDPP-------LAGPKDTSTPDGP-------PLAPAAA 1429
Query: 1218 VKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDS 1277
V P + + + G EE P T P PALP+
Sbjct: 1430 VPG-PPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPL 1488
Query: 1278 EATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLE 1337
A S P P P PPA PP P PA A L + P +
Sbjct: 1489 VAPTPSSPPPPPLP---------------PPPPPAMPSPPPPPPPAAAPLAAPPEEPAAP 1533
Query: 1338 APEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRR----- 1392
+PE E + +P L +++E GE + E E S GEG R R
Sbjct: 1534 SPE--DPELPDTRPLHLAKKQETAAVCGETDEEAGE---------SGGEGIFRERDEFVI 1582
Query: 1393 ------SLRSHARRRRPPPP 1406
SL+ + R PPP
Sbjct: 1583 RAEDIPSLKLALQTGREPPP 1602
Score = 48.5 bits (114), Expect = 5e-05
Identities = 32/88 (36%), Positives = 36/88 (40%), Gaps = 28/88 (31%)
Query: 596 PAPTPPQQPPPPPPPPPP---PPPY--LASLPLGYPPHQPA----YLLPPRPDGPPPPE- 645
PA TPP +P PP PPPPP P + LAS + + Y GPPPPE
Sbjct: 221 PAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPER 280
Query: 646 ------------------YPPPPPPPPH 655
PPPPPPP H
Sbjct: 281 ALPRQDTVIKHYQRPASAQPPPPPPPAH 308
Score = 46.2 bits (108), Expect = 3e-04
Identities = 71/330 (21%), Positives = 113/330 (34%), Gaps = 49/330 (14%)
Query: 912 PRPSTPAEEDEDDPEQEKEAG---EPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEA 968
P P+ P+ P A EP P + P+ + R K +++ A+ E +E
Sbjct: 1505 PPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEE 1564
Query: 969 SQESSSEKD-EEDDEEDEEDED------------------REEAVDTTKKETEVSDGEDE 1009
+ ES E E DE ED R + K E+ DG+ +
Sbjct: 1565 AGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQ 1624
Query: 1010 ESDSSSKCSLYADSDG----------ENDSTSDSESSSSSSS----------SSSSSSSS 1049
+S+ + D+ EN + D + S + +
Sbjct: 1625 FCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPV 1684
Query: 1050 SSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLP 1109
S+ SS+ + + E P S PP + P A E P PE+ +
Sbjct: 1685 SAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQ---TPETAMPEPPAPEKPSLLRPVEKE 1741
Query: 1110 EQEASPARPAGPT--EESPPSAPLRPPEPPA-GPPAPAPRPDERPSSPIPLLPPPKKRRK 1166
+++ R P E + RP A G PA + P RP+ + PPPKKR+K
Sbjct: 1742 KEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARPTK-VKAEPPPKKRKK 1800
Query: 1167 TVSFSAIEVVPAPEPPPATPPQAKFPGPAS 1196
+ + PP ++ PG S
Sbjct: 1801 WLKEAGGNATAGGGPPGSSSDSESSPGAPS 1830
Score = 44.7 bits (104), Expect = 8e-04
Identities = 69/304 (22%), Positives = 92/304 (30%), Gaps = 65/304 (21%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGG 442
PP + +PP P A PP + P P P PPA +PPP PP
Sbjct: 1462 PPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPP--- 1518
Query: 443 GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSK 502
+P A P +P+PE + +P D+R L K+Q +
Sbjct: 1519 --------------AAAPLAAPPEEPAAPSPE--DPELP-------DTRPLHLAKKQETA 1555
Query: 503 FSFLASDTEEEEENSSMVLGARD----TGSEVPS-----GSGHGPCTPP------PAPAN 547
+D E E + RD ++PS +G P PP
Sbjct: 1556 AVCGETDEEAGESGGEGIFRERDEFVIRAEDIPSLKLALQTGREP--PPIWRVQKALLQK 1613
Query: 548 FEDVAPTGSGEPGATRE----SPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPP-- 601
F G + AT A + Q +++ D R + P PP
Sbjct: 1614 FTPEIKDGQRQFCATSNYLGYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVP 1673
Query: 602 ----------------QQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPE 645
PPP P PPP P PP Q P P P P
Sbjct: 1674 VRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPS 1733
Query: 646 YPPP 649
P
Sbjct: 1734 LLRP 1737
Score = 40.4 bits (93), Expect = 0.015
Identities = 101/428 (23%), Positives = 130/428 (30%), Gaps = 102/428 (23%)
Query: 383 PPRRATREEPPGAP--------------FAENTAERFPPSYTSYL-----PPEPSRPTDQ 423
PP R +PP P A AE+ P ++ PP P R +
Sbjct: 225 PPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPR 284
Query: 424 D------YRPPASEAPPPEPPEPGG-------GG----------------GGGGPSPERE 454
Y+ PAS PPP PP GG GGG PSP
Sbjct: 285 QDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAG 344
Query: 455 EVRTSPRPASP--ARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512
E P A P A +G+ T E+ +++ K
Sbjct: 345 E----PSKAGPSGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSPGYK---------- 390
Query: 513 EEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQN 572
TG G+ G T PP P + G P A + KA+G
Sbjct: 391 -------------TGKG-GYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAG 436
Query: 573 QAS--PCSSGDDMEISDDDR-------GGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPL 623
A S G + G + + P PP PP PPPP LA+
Sbjct: 437 GAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQ- 495
Query: 624 GYPPHQ---PAYLLPPRP-DGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMS 679
Y P Q Y + P GP P P Y +S L G WG +
Sbjct: 496 SYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTGHSPALSGH-GGGWGPSSLG 554
Query: 680 FQMQTQMLTRLHQLRQ----GKGLIAASAGPPGGAFGE--AFLPFPPPQEAAYGLPYALY 733
+ + L+ G+ S G PG A PF P A YA
Sbjct: 555 GGGEASPSHIIRPLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAG---SYAAG 611
Query: 734 AQGQEGRG 741
A G +G+G
Sbjct: 612 AGGYKGKG 619
Score = 40.0 bits (92), Expect = 0.019
Identities = 109/498 (21%), Positives = 147/498 (29%), Gaps = 125/498 (25%)
Query: 265 PQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS 324
P + G P + Y + + S S+ ++ ++ A++ H S A+
Sbjct: 6 PSAGFGDPLGAGAGWSYERSAKASLVYGSSRTSHPETDILHRQAYAAPHPLQSYATNHHP 65
Query: 325 TAIAATT------AATASSSASSSSLSSSSSS-------SSSSSSSQFRSSDANYPAYYE 371
++ A +A AS +L S+ S S+SS SQFRS
Sbjct: 66 AGLSGLFDTGLHHAGSAGPDASVMNLISALESRGPQPGPSASSLLSQFRSP--------- 116
Query: 372 SWNRYQRHTSYPPRRATREEPPGAPFAENT----AERFPPSYTSYLPPEPSRPTDQD--Y 425
SW HT P PG+ ++ A + P S+ S P PS + QD +
Sbjct: 117 SWQTAM-HTPGPTELFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPF 175
Query: 426 RPPASEA----------PPPEPPEPGGGG-----GGGGPSPEREEVRTSPRPASPARSGS 470
PPA+ P P P G GGG P P P R G
Sbjct: 176 SPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGP----AGLGPAQTPPYRPGP 231
Query: 471 PAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEV 530
P P +P + S EQ S + S L +DT +
Sbjct: 232 PDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKH 291
Query: 531 PSGSGHGPCTPPPAPANFED-------------------VAPTGSGEPGATRESPKANGQ 571
PPP PA+ +P G GEP P G
Sbjct: 292 YQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGP 351
Query: 572 NQASPCSSG--DDMEISDDDRGGSPPPAPTPPQQPP-----------------PPPPPPP 612
+ A+ +SG E + G P Q P PPPP
Sbjct: 352 SGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRS 411
Query: 613 PPPPYLASL-------------------PLGYPPHQPAYLLPPR---------------- 637
P SL Y P QP LL P+
Sbjct: 412 TATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQGLLGPQAYGQGFGGGQAQDLSK 471
Query: 638 ----PDGPPPPEYPPPPP 651
GPP P PPPP
Sbjct: 472 APSYSGGPPQPPSGPPPP 489
Score = 39.3 bits (90), Expect = 0.033
Identities = 75/321 (23%), Positives = 99/321 (30%), Gaps = 60/321 (18%)
Query: 1104 PVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLP---- 1159
P T P SP P SAP P P AG A + LL
Sbjct: 572 PATGRPPGVGSPGAPGKYLSSVLASAPFLAP-PGAGSYAAGAGGYKGKGDGSELLAGPGG 630
Query: 1160 PPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERT--IRNLPLDHASL 1217
PP +R + F ++ AP PP + + A +G+ + P L
Sbjct: 631 PPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPYEL 690
Query: 1218 VKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDS 1277
K P+ R + +E A E+ L L + P R G
Sbjct: 691 AKEDPQRYHLQSVIRTSA----SLDEGATAALELGLGRLKEKKKGPERGG---------- 736
Query: 1278 EATETSDEAERPRPLLSHIL------LEHNYALAVKPTPPAPALRPPEPVPAPAALFSSP 1331
E P L + ++ E L P PP P + +P P L +
Sbjct: 737 ---------ETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGG 787
Query: 1332 ADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRR 1391
D L P P PQ L S S S+S L
Sbjct: 788 PDLPLVLPP--------PPPQLLPSVLSHAP--------------SPSPSASKVGVHLLE 825
Query: 1392 RSLRSHARRRRPPPPPPPPPP 1412
+ R A + PPPPPPPPPP
Sbjct: 826 PATRDGAPQ--PPPPPPPPPP 844
Score = 35.8 bits (81), Expect = 0.37
Identities = 74/340 (21%), Positives = 105/340 (30%), Gaps = 70/340 (20%)
Query: 1103 SPVTPLPEQEASPARPAGPT-EESPPSAPL-RPPEPPAGPP-----APAPRPDE------ 1149
SP P P +++ P G E P PL PP PP P AP+P P
Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVH 822
Query: 1150 -----------RPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198
+P P P PPP + + + PA P P ++ P A ++
Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQE 882
Query: 1199 APRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLAD 1258
+E PL A S G R + +A + D
Sbjct: 883 LLGALE------PLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPD 936
Query: 1259 LALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPP 1318
L R P +E+ +D+ + P E + P P PA P
Sbjct: 937 SLLQDEERSF--FPTMEEMFGGGAADDYGKAGPPED----EGDPKAGAGPPPGPPAYDPY 990
Query: 1319 EPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD 1378
P P PE + KP +L
Sbjct: 991 GPY--------CPGRASGAGPETPGLGLDPNKPPELP----------------------- 1019
Query: 1379 SSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPR 1418
S+ +++ G ++ H PPPPPPPPP A EP+
Sbjct: 1020 STVNAEPLGLIQSGP---HQAAPPPPPPPPPPPAPASEPK 1056
Score = 34.7 bits (78), Expect = 0.82
Identities = 63/229 (27%), Positives = 75/229 (32%), Gaps = 60/229 (26%)
Query: 591 GGSPPPAPTPPQQPPPPPPPP--------------PPPPPYLASLPLGYPPHQPAYLLPP 636
G P P P+ PP PP P P + S LG+ +L P
Sbjct: 158 GSRPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTVPS-SLGFERLAGGGVLGP 216
Query: 637 RPDGP---PP--PEYPPPPPPPPHIYDFVNSL---------------ELMDRLGAQWGGM 676
GP PP P P PPPPP H+ N L +L + GA G
Sbjct: 217 AGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPP 276
Query: 677 PMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEA-----AYGLPYA 731
P + Q H R ASA PP P PPP A + G Y
Sbjct: 277 PPERALPRQDTVIKHYQR------PASAQPP---------PPPPPAHALQHYLSCGGSYP 321
Query: 732 LYAQGQEGRGAYSREAYHLPMPMAAEPL---PSSSVSGEEARLPPREEA 777
+ G A S P P A EP PS + +G R E A
Sbjct: 322 --SMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAA 368
Score = 33.1 bits (74), Expect = 2.4
Identities = 42/172 (24%), Positives = 62/172 (36%), Gaps = 13/172 (7%)
Query: 1039 SSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP--PREVPVPTPAPVEVPV 1096
S + SS+ SSS+ S+ +S P++L PP P + +P V
Sbjct: 133 SGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLK 192
Query: 1097 PERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDE---RPSS 1153
P + P + L + + GP P P P PP PP P P + SS
Sbjct: 193 PSQAPTVP-SSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASS 251
Query: 1154 PIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQ-----AKFPGPASRKAP 1200
+ + +FS P P PP P+ + PAS + P
Sbjct: 252 SAAAAAAEQSSPQLYNFSG--AAPGPPPPERALPRQDTVIKHYQRPASAQPP 301
Score = 32.0 bits (71), Expect = 5.3
Identities = 35/108 (32%), Positives = 40/108 (37%), Gaps = 16/108 (14%)
Query: 380 TSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPP---PE 436
+S PP +A PP E T PP T PE + P PPA E P P
Sbjct: 1689 SSAPPPKAP-APPPKPETPEKTTSEKPPEQT----PETAMP-----EPPAPEKPSLLRPV 1738
Query: 437 PPEPGGGGGGGGPSPEREEVRTSPRPASPARS---GSPAPETTNESVP 481
E G P R E TS R P RS G PA ++ P
Sbjct: 1739 EKEKEKEKVTRGERPLRGERATSGRQTRPERSLATGQPATSRLPKARP 1786
Score = 32.0 bits (71), Expect = 5.3
Identities = 42/188 (22%), Positives = 64/188 (34%), Gaps = 12/188 (6%)
Query: 406 PPSYTSYLPPEPSRPTDQDYRPPASEAPP---PEPPEPGGGG--GGGGPSPEREEVRTSP 460
PP PP+P P P + P PEPP P E+E+V
Sbjct: 1692 PPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGE 1751
Query: 461 RPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMV 520
RP R+ S S+ Q ++ L K + +K A ++ +
Sbjct: 1752 RPLRGERATSGRQTRPERSLATGQPAT-----SRLPKARPTKVK--AEPPPKKRKKWLKE 1804
Query: 521 LGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSG 580
G T P GS + P AP+ E P + A RE ++ + S
Sbjct: 1805 AGGNATAGGGPPGSSSDSESSPGAPSEDERAVPGRLLKTRAMREMYRSYVEMLVSTALDP 1864
Query: 581 DDMEISDD 588
D ++ +D
Sbjct: 1865 DMIQALED 1872
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 99.8 bits (247), Expect = 2e-20
Identities = 263/1201 (21%), Positives = 397/1201 (33%), Gaps = 233/1201 (19%)
Query: 366 YPAYYE-SWNRYQRHTSYP-------PRRATREEP----PGAPFAENTAERFPPSYTSY- 412
Y Y E + RY+ H Y P + EEP P AP A+ + P
Sbjct: 9768 YEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVP 9827
Query: 413 -----------LPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPR 461
+P EP + ++ R ++ + EP EE PR
Sbjct: 9828 IPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPR 9887
Query: 462 P--ASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSM 519
A P R E E V F + + + +E L E+ ++ + EEE +
Sbjct: 9888 KEVAPPVRVPEVPKELEPEEVAFEEE--VVTHVEEYLVEEEEEYIHEEEEFITEEEVVPV 9945
Query: 520 V-----------LGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPT-----GSGEPGATR 563
+ + VP P P P E+ P P
Sbjct: 9946 IPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVP 10005
Query: 564 ESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP--PQQPPPPPPPPPPPPPYLASL 621
E PK + P +E PPA P P++P P P P P + +
Sbjct: 10006 EVPKKPVPEEKVPVPVPKKVEA---------PPAKVPEVPKKPVPEKKVPVPAPKKVEAP 10056
Query: 622 PLGYPPHQPAYLLPP-RPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSF 680
P P P L+P + P P + PPP P + V +P++
Sbjct: 10057 PAKVP-EVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVP--------------VPVAL 10101
Query: 681 QMQTQMLTRLHQLRQGKGLIAASAGPPGGAF----GEAFLP----FPPPQEAAYGLPYAL 732
+ ++L + + + L P E LP PP +E P
Sbjct: 10102 PQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVP--PEEE 10159
Query: 733 YAQGQEGRGAYSREAYHLPMPMAAEPLPS------SSVSGEEARLPPREEAELAEGKTLP 786
Y +E + E LP P+P+ V+ ++ +P +EEA A+ +P
Sbjct: 10160 YVPEEE---EFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVP 10216
Query: 787 TAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAK 846
V+E + I+ ++ VE ++E + +P +
Sbjct: 10217 KK----------VEEKRIILPKEEEVLPVE-----------VTEEPEEEPISEEEIPEEP 10255
Query: 847 EEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSE-ISE 905
+E ++ P + ++ A T + + P KV +K P E +
Sbjct: 10256 PSIEEVEEVAPPRVPEVIKKAVPEAPTPVPK---------KVEAPPAKVSKKIPEEKVPV 10306
Query: 906 ASEEKRPRPSTPAEEDEDDPEQE-----KEAGEPGRPGTKPPKRDEE--RGKTQGKHRKS 958
++K P+ E + PE++ KEA P + T ++ R + K R
Sbjct: 10307 PVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLE 10366
Query: 959 F-ALDSEGEEASQESSSEKDEEDDEEDEEDE------------DREEAVDTTKKETEVSD 1005
+++E EE +E + EE EE E E + E V+ + EV +
Sbjct: 10367 LEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFE 10426
Query: 1006 GEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065
E+ E K E + + E E
Sbjct: 10427 AEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPE 10486
Query: 1066 EEEERPAALPSASPPP-----REVPVPTPAPVEVPVPERVAGSPVTPLPEQEAS---PAR 1117
E P +P PP ++VPVP E P P +V +P +PE++ P +
Sbjct: 10487 EPRVPPTKVPEVLPPKEVVPEKKVPVPPAKKPEAP-PPKVPEAPKEVVPEKKVPVPPPKK 10545
Query: 1118 PAGPTEESPPSAPLRPPE---PPAGPPAPAPRPDERPSSPIPLLP-------PPKKRRKT 1167
P P + P PE P A PP P P E P +P ++P PPKK T
Sbjct: 10546 PEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVT 10605
Query: 1168 ---VSFSAIEVVP---APEPPPATP--PQAKFPGPASRKAP-RGVERTIRNLPLDHASLV 1218
V + EVVP P PPP P P K P P + V I P V
Sbjct: 10606 PVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEV 10665
Query: 1219 KSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSE 1278
PEEV+ EE AE E + A + + P + P E
Sbjct: 10666 FEEPEEVA-------------LEEPPAEVVEEPEPAAPPQVTVPPKK------PVPEKKA 10706
Query: 1279 ATETSDEAERP----RPLLSHILLEHNYALAVKPTPPAPALRPPE--------------- 1319
+ + E P + ++ E L V P AP + PE
Sbjct: 10707 PAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPK 10766
Query: 1320 -PVPAPAALFSSPADEVL-EAPEVVVAE-AEEPKPQQLQQQREEGEEE---GEEE----- 1368
P PA + P VL E P V V E AE P P+ ++ E EE EEE
Sbjct: 10767 KPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPV 10826
Query: 1369 GEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPP---------------PPPPPPPR 1413
EEEE E + + + + + + + PPP P PPPPP
Sbjct: 10827 AEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPP 10886
Query: 1414 A 1414
A
Sbjct: 10887 A 10887
Score = 74.7 bits (182), Expect = 7e-13
Identities = 92/368 (25%), Positives = 126/368 (34%), Gaps = 49/368 (13%)
Query: 1069 ERPAALPSASP-PPREVPVPTPAPV-----EVPVPERVAGSPVTPLPE-QEASPARPAGP 1121
E+ A+P PP +VP PV VPVPER P E +E +P P
Sbjct: 10759 EKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAP 10818
Query: 1122 TEESPPSAPLRPPEPPAGPPAPAPRPDER--PSSPIPLL-----PPPKKRRKTVSFSAIE 1174
EE P P+ E P PP P ++ P +P++ PPPK+ +
Sbjct: 10819 EEEKP--VPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPK 10876
Query: 1175 VVPAPEPPPATPPQ-------------AKFPGPASRKAPRGVERTIRNLPLDHASLVKSW 1221
+ P P PPP PP+ K P + P VE T +P + K
Sbjct: 10877 LKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLL 10936
Query: 1222 PEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATE 1281
PE EE EP +V+ L + P P E T
Sbjct: 10937 PERKPEPKEEVVLKSVLRKRPEEEEP--KVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTV 10994
Query: 1282 TSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLE-APE 1340
T E + P P +KP P PA PEP P P A + +E P
Sbjct: 10995 TKRERKIPEP---------TKVPEIKPAIPLPA---PEPKPKPEAEVKTIKPPPVEPEPT 11042
Query: 1341 VVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARR 1400
+ A P + + + EE + +G + S RR LR +
Sbjct: 11043 PIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIE-----AERRKLRPGSGG 11097
Query: 1401 RRPPPPPP 1408
+PP P
Sbjct: 11098 EKPPDEAP 11105
Score = 73.2 bits (178), Expect = 2e-12
Identities = 106/415 (25%), Positives = 154/415 (37%), Gaps = 90/415 (21%)
Query: 1065 EEEEERPAALPSASP---PPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGP 1121
++ E P +P A P ++VPVP P EVP P +V P +PE++ A P P
Sbjct: 10600 KKPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVP-PTKVPEVPKVAVPEKKVPEAIP--P 10656
Query: 1122 TEESPPSAPLRPPEPPAGPPAPAPRPDE-RPSSPIPLLPPPKKRRKTVSFSAIEVVPAPE 1180
ESPP PE A PA +E P++P + PPKK A+ V PE
Sbjct: 10657 KPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAV-VAKKPE 10715
Query: 1181 PPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLT 1240
PP P+ +K P V + P + V P+EV +
Sbjct: 10716 LPPVKVPEVPKEVVPEKKVPLVVPKKPEAPP----AKVPEVPKEV-------------VP 10758
Query: 1241 EEEEAEPGT-EVDLAVLADLALTPARRGLPALPAVEDSEAT---------------ETSD 1284
E++ A P EV A + ++ P PA+P E +E+ E +
Sbjct: 10759 EKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAP 10818
Query: 1285 EAERPRPLLSH----------------ILLEHNYALAVKPTPPAPAL------------- 1315
E E+P P+ I+ E + KP P P
Sbjct: 10819 EEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLK 10878
Query: 1316 -RPPEPVPAPAA---------LFSSPADEVLEAPEVVVAEAEEPKPQQL----QQQREEG 1361
RPP P PAP L + P +V E P+V E E P ++ ++ R+
Sbjct: 10879 PRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQV--PEKVELTPLKVPGGEKKVRKLL 10936
Query: 1362 EEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYE 1416
E E EE +S + E + + L + + P P PPPP+ E
Sbjct: 10937 PERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLE----KVKKPAVPEPPPPKPVE 10987
Score = 72.4 bits (176), Expect = 4e-12
Identities = 128/612 (20%), Positives = 202/612 (33%), Gaps = 161/612 (26%)
Query: 894 KVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE------- 946
++ ++E ++ +E P+ P E PE++ +P R P K E
Sbjct: 9642 QITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVK 9701
Query: 947 ------ERGKTQGKHRKSFALDSEGEEA---SQESSSEKDEEDDEEDEEDEDRE-EAVDT 996
E K + + K + E E A +E+ S + EE+ EE EE + +E E +
Sbjct: 9702 EEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEP 9761
Query: 997 TKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSS 1056
T++ + + E+ E + + Y +E + +
Sbjct: 9762 TEEYDQYEEYEEREYERYEEHEEYI-----------TEPEKPIPVKPVPEEPVPTKPKAP 9810
Query: 1057 SSESSSEDEEEEERPAALP-SASPPPREVP----------------------VPTPAPVE 1093
++ + EE+ P +P PPP +VP V PA
Sbjct: 9811 PAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKV 9870
Query: 1094 VPVPERVAGSPVTPLPEQEASP--ARPAGPTEESP------------------------- 1126
P+RV P+P +E +P P P E P
Sbjct: 9871 PMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYI 9930
Query: 1127 -------------PSAPLRPPEPPAGP------PAPAPRPDERPSSPIPLLPPPKKRRKT 1167
P P++ PE P P P P P+ E P + +P +P +
Sbjct: 9931 HEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPE---- 9986
Query: 1168 VSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSR 1227
E VP P PP AK P + P +P+ V++ P +V
Sbjct: 9987 ------EKVPVLIPKKEKPPPAKVPEVPKKPVPE------EKVPVPVPKKVEAPPAKV-- 10032
Query: 1228 GGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAE 1287
E +P E + V PA + + A PA + E +
Sbjct: 10033 -------------PEVPKKPVPEKKVPV-------PAPKKVEAPPAKVPEVPKKLIPEEK 10072
Query: 1288 RPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSS----------PADEVLE 1337
+P P+ + PP + EPVP P AL P +EVL
Sbjct: 10073 KPTPVPKKV-----------EAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLP 10121
Query: 1338 APEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSH 1397
E V+ E EE P++ EE E EE EEEE + + E + +
Sbjct: 10122 EEEEVLPEEEEVLPEE-----EEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPE 10176
Query: 1398 ARRRRPPPPPPP 1409
+ + P P P P
Sbjct: 10177 VKPKVPVPAPVP 10188
Score = 70.1 bits (170), Expect = 2e-11
Identities = 100/386 (25%), Positives = 140/386 (36%), Gaps = 57/386 (14%)
Query: 1063 EDEE---EEERPAALPSASPPPREVPVPTPA-PVEVPVPERVAGSPVTPLPEQEASPARP 1118
E+EE EEE +P P PVP PV VP + + V +P++
Sbjct: 9932 EEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPV 9991
Query: 1119 AGPTEESPPSAPLRPPEPPAGP------PAPAPRPDERPSSPIPLLPP---PKKRRKTVS 1169
P +E PP P + PE P P P P P+ E P + +P +P P+K+ +
Sbjct: 9992 LIPKKEKPP--PAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPA 10049
Query: 1170 FSAIEVVPA--PEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSR 1227
+E PA PE P P+ K P P P+ VE +P + P V+
Sbjct: 10050 PKKVEAPPAKVPEVPKKLIPEEKKPTP----VPKKVEAPPPKVPKKREPV----PVPVAL 10101
Query: 1228 GGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVED--SEATETSDE 1285
+ EEE P E L ++ LP E+ E E E
Sbjct: 10102 PQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEV-----------LPEEEEVLPEEEEIPPE 10150
Query: 1286 AERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVL-------EA 1338
E P ++ E + V P ++P PVPAP E EA
Sbjct: 10151 EEEVPPEEEYVPEEEEF---VPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEA 10207
Query: 1339 PEVVVAE----AEEPK---PQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRR 1391
P V E EE + P++ + E EE EEE EEE + S + E
Sbjct: 10208 PPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPP 10267
Query: 1392 RSLRSHARRRRPPPPPPPPPPRAYEP 1417
R ++ P P P P + P
Sbjct: 10268 RV--PEVIKKAVPEAPTPVPKKVEAP 10291
Score = 66.6 bits (161), Expect = 2e-10
Identities = 122/534 (22%), Positives = 181/534 (33%), Gaps = 60/534 (11%)
Query: 890 LPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERG 949
LP +V ++ + A + + P P P E PE++ P +P P K E
Sbjct: 10499 LPPKEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEV-- 10556
Query: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
K+ + + EA E E +E ++ K+ EV+ +
Sbjct: 10557 ------PKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVP 10610
Query: 1010 ESDS----SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDE 1065
E+ K + E T E + + S E E E
Sbjct: 10611 EAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEVFEEPE 10670
Query: 1066 EEEERPAALPSASPPPREVPVPTP-APVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
E + PP V P P AP +V VP P P+PE++A PA A E
Sbjct: 10671 E-------VALEEPPAEVVEEPEPAAPPQVTVP------PKKPVPEKKA-PAVVAKKPEL 10716
Query: 1125 SPPSAPLRPPE--PPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP 1182
P P P E P P P+ E P + +P +P ++ V + V PE P
Sbjct: 10717 PPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVP-----KEVVPEKKVAVPKKPEVP 10771
Query: 1183 PATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEE 1242
PA P+ K V + P + V PEE++ +
Sbjct: 10772 PAKVPEVPKKPVLEEKPAVPVPERAESPPPE----VYEEPEEIAPEEEIAPEEEKPVPVA 10827
Query: 1243 EEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNY 1302
EE EP + P ++ +P + E E E +P L
Sbjct: 10828 EEEEPEVPPPAVPEEPKKIIPEKK-VPVIKKPEAPPPKEPEPEKVIEKPKL--------- 10877
Query: 1303 ALAVKPTPPAPALRPP-EPVPAPA-ALFSSPADEVLEAPEVVVAEAEEPKPQQL----QQ 1356
KP PP P PP E V L + P +V E P+ V E E P ++ ++
Sbjct: 10878 ----KPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQ--VPEKVELTPLKVPGGEKK 10931
Query: 1357 QREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPP 1410
R+ E E EE +S + E + + L + P PPPP P
Sbjct: 10932 VRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKP 10985
Score = 62.0 bits (149), Expect = 5e-09
Identities = 130/586 (22%), Positives = 201/586 (34%), Gaps = 130/586 (22%)
Query: 896 KRKEPSE---ISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQ 952
K+K P E + EE P P PA + PE++ P PP R E KT
Sbjct: 9404 KKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKAPPP-RAEVSKKTV 9462
Query: 953 GKHRK-------SFALDSEGEEASQESSSEKDEEDDEEDE-------EDEDREEAVDTTK 998
+ ++ SFA+ E E S+E++ EE+E +E+REE +
Sbjct: 9463 VEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEV 9522
Query: 999 KETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSS 1058
E EV + E EE K + S + + +
Sbjct: 9523 TEYEVME-EPEEYVVEEKLHII-----------------SKRVEAEPAEVTERQEKKIVL 9564
Query: 1059 ESSSEDEEEEERPAALPSASP---PPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
+ + EE PA +P A P ++VP P P +VP P +V P P+PE++ P
Sbjct: 9565 KPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEKVP-PPKVPEEPKKPVPEKKVPP 9623
Query: 1116 -------ARPAGPTE------------------ESPPSAPLRPPEPPAGPPAP-----AP 1145
PA TE E+PP A + P EP P P
Sbjct: 9624 KVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARV-PEEPKRAVPEEKVLKLKP 9682
Query: 1146 RPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVER 1205
+ +E P + + + + VS A P EP P K +E
Sbjct: 9683 KREEEPPAKVTEFRKRVVKEEKVSIEA----PKREPQPI-------------KEVTIMEE 9725
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265
R L+ E VS + EEE E E D + T
Sbjct: 9726 KERAYTLEE--------EAVS------------VQREEEYEEYEEYDYKEFEEYEPT--- 9762
Query: 1266 RGLPALPAVEDSEATETSDEAERPR-PLLSHILLEHNYALAVKPTPPAPALRPPEPVPAP 1324
E+ + E +E E R + E + VKP P P P+ PA
Sbjct: 9763 ---------EEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAK 9813
Query: 1325 AALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSD 1384
+ P ++V P + + + P P+ ++ ++ EE+ + E+E ++
Sbjct: 9814 VLKKAVPEEKV---PVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAK- 9869
Query: 1385 GEGALRRRSLRSHARRRRP-PPPPPPPPPRAYEPRSEFEQMTILYD 1429
+ + R A + P P PP R E E E + ++
Sbjct: 9870 ----VPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFE 9911
Score = 59.3 bits (142), Expect = 3e-08
Identities = 81/329 (24%), Positives = 119/329 (36%), Gaps = 50/329 (15%)
Query: 1062 SEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGP 1121
S+ E + LP P PVP P VE P P +V P P+PE++ +P P
Sbjct: 9279 SKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAP-KVPEVPKKPVPEEK----KPV-P 9332
Query: 1122 TEESPPSAPLRPPEPPAGP------PAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEV 1175
+ P+AP + PE P P P P + E P + +P + ++ V+ I +
Sbjct: 9333 VPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVP-----EVQKGVVTEEKITI 9387
Query: 1176 VPAPE--PPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEE-------VS 1226
V E PPPA P K P RK E + P A K PEE V+
Sbjct: 9388 VTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVA 9447
Query: 1227 RGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATE----- 1281
+ + T EE E L+ + R + A SE E
Sbjct: 9448 KKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSIS 9507
Query: 1282 ----TSDEAERPRPLLSHILLE-----------HNYALAVKPTPPAPALRPPEPV----P 1322
E E + + ++E H + V+ P R + +
Sbjct: 9508 VYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPK 9567
Query: 1323 APAALFSSPADEVLEAPEVVVAEAEEPKP 1351
PA + P +V EAP+ +V E + P P
Sbjct: 9568 IPAKIEEPPPAKVPEAPKKIVPEKKVPAP 9596
Score = 56.6 bits (135), Expect = 2e-07
Identities = 127/562 (22%), Positives = 191/562 (33%), Gaps = 134/562 (23%)
Query: 899 EPSEISEASE--EKRPRPST--PAEEDE--DDPEQEKEAGEPGRPGTKPPKRDEER--GK 950
+P E++ E +K P P+T PA+ E D + +E K ++++E K
Sbjct: 8999 KPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEK 9058
Query: 951 TQGKHRKSFALDSEGEEASQESSSEKDEEDDEE---DEEDEDREEAVDTTKKETEVSDGE 1007
Q H++ EE E E E E+ +E DED EE KKE E
Sbjct: 9059 KQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYEEIKVEAKKEVH----E 9114
Query: 1008 DEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
+ E D Y +G ++ + E + + E+ E
Sbjct: 9115 EWEEDFEEGQEYYEREEGYDEGEEEWE------------EAYQEREVIQVQKEVYEESHE 9162
Query: 1068 EERPAALP--SASPPPREVPVPTPAPVE---------------VP------VPERVAGSP 1104
+ PA +P A PPP+ + P +E VP VP++ + +P
Sbjct: 9163 RKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTP 9222
Query: 1105 V------TPLP--------------------EQEASPARPAGPTE--------------- 1123
V +P E+E S P E
Sbjct: 9223 VQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRV 9282
Query: 1124 ESPPSAPLRP--PEPPAGPPAPAPRPDERPSSPIPLLP--PPKKRRKTVSFSAIEVVPAP 1179
E PP P P P P P P P+ E P+ +P +P P + +K VP P
Sbjct: 9283 EPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKP--------VPVP 9334
Query: 1180 EPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRL 1239
+ PA PP K P + P +P+ A ++ P +V +G +
Sbjct: 9335 KKEPAAPP--KVPEVPKKPVPE------EKIPVPVAKKKEAPPAKVPE------VQKGVV 9380
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLE 1299
TEE ++ + + + PA +P E+ + +E P P +
Sbjct: 9381 TEE-------KITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVP----- 9428
Query: 1300 HNYALAVKPTPPAPALRP-PEPVPAPAALFSSPADEVLEAPEVVVAE-AEEPKPQQLQQQ 1357
AL KP P P P AP V+E V E PQ+++
Sbjct: 9429 ---ALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVT 9485
Query: 1358 REEGEEEGEEEGEEEEEESSDS 1379
R E E E EEEE S S
Sbjct: 9486 RHEVSAEEEWSYSEEEEGVSIS 9507
Score = 44.7 bits (104), Expect = 8e-04
Identities = 45/173 (26%), Positives = 61/173 (35%), Gaps = 24/173 (13%)
Query: 1063 EDEEEEERPAALPSAS-------PPPR-----EVPVPTPAPVEVPVPERVAG-SPVTPLP 1109
E+EE + P L PPP+ EVP T ++P P +V P PLP
Sbjct: 10958 EEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTKVPEIKPAIPLP 11017
Query: 1110 EQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVS 1169
E P A PP P+ P P P P ++ + P K
Sbjct: 11018 APEPKPKPEAEVKTIKPP--PVEPEPTPIAAPVTVPVVGKKAEAKAP------KEEAAKP 11069
Query: 1170 FSAIEVVPAPEPPPATPPQAKF-PGPASRKAPRGVERT--IRNLPLDHASLVK 1219
I+ VP P P + K PG K P T ++ +PL +K
Sbjct: 11070 KGPIKGVPKKTPSPIEAERRKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIK 11122
Score = 40.8 bits (94), Expect = 0.011
Identities = 46/185 (24%), Positives = 62/185 (33%), Gaps = 44/185 (23%)
Query: 1067 EEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESP 1126
EEE P P ++ VP P P P P +E P E
Sbjct: 10958 EEEEPKVEPKKLEKVKKPAVPEPPP---------------PKPVEEVEV--PTVTKRERK 11000
Query: 1127 PSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATP 1186
P + PE P PAP P +P + + + PP +E P P P T
Sbjct: 11001 IPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPP----------PVEPEPTPIAAPVTV 11050
Query: 1187 P------QAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLT 1240
P +AK P + K P+G I+ +P K P + R G G
Sbjct: 11051 PVVGKKAEAKAPKEEAAK-PKG---PIKGVP-------KKTPSPIEAERRKLRPGSGGEK 11099
Query: 1241 EEEEA 1245
+EA
Sbjct: 11100 PPDEA 11104
Score = 39.7 bits (91), Expect = 0.025
Identities = 64/302 (21%), Positives = 98/302 (32%), Gaps = 55/302 (18%)
Query: 377 QRHTSYPPRRATREEPPGAPFAENTA---ERFPPSYTSYLPPEPSRPTDQDYRPP---AS 430
++ PP + P P A ++ P + +PP+P P + + P A
Sbjct: 10619 EKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEA----IPPKPESPPPEVFEEPEEVAL 10674
Query: 431 EAPPPEP-PEPGGGGGGGGPSPEREEVRTSPRPASPARSGS----PAPETTNESVPFAQH 485
E PP E EP P ++ V PA A+ PE E VP
Sbjct: 10675 EEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVP---- 10730
Query: 486 SSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGS-GHGPCTPPPA 544
+ ++ +++ ++ + +E V A EVP P P
Sbjct: 10731 ---EKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKV--AVPKKPEVPPAKVPEVPKKPVLE 10785
Query: 545 PANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPA-PTPPQQ 603
V P E P+ + + +++++ PPPA P P++
Sbjct: 10786 EKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKK 10845
Query: 604 -----------PPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPP 652
P PPP P P + P L PRP PPPPP
Sbjct: 10846 IIPEKKVPVIKKPEAPPPKEPEPEKVIEKP----------KLKPRP--------PPPPPA 10887
Query: 653 PP 654
PP
Sbjct: 10888 PP 10889
Score = 38.9 bits (89), Expect = 0.043
Identities = 65/284 (22%), Positives = 92/284 (32%), Gaps = 41/284 (14%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGG 443
P EEPP A E PP T +PP+ P + + PA A PE P
Sbjct: 10669 PEEVALEEPP-AEVVEEPEPAAPPQVT--VPPKKPVP---EKKAPAVVAKKPELPPVKVP 10722
Query: 444 GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKF 503
PE++ P+ P + PE E VP + ++ + K +
Sbjct: 10723 EVPKEVVPEKKVPLVVPK--KPEAPPAKVPEVPKEVVP-------EKKVAVPKKPE---- 10769
Query: 504 SFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATR 563
+ E VL + VP PP E++AP P +
Sbjct: 10770 ---VPPAKVPEVPKKPVLEEKPA-VPVPE---RAESPPPEVYEEPEEIAPEEEIAPEEEK 10822
Query: 564 ESPKANGQNQA--SPCSSGDDMEISDDDR-------GGSPPPAPTP------PQQPPPPP 608
P A + P + +I + + PP P P P+ P PP
Sbjct: 10823 PVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPP 10882
Query: 609 PPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPP 652
PPPP PP + P +P +P P E P P
Sbjct: 10883 PPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVP 10926
Score = 37.7 bits (86), Expect = 0.096
Identities = 44/178 (24%), Positives = 66/178 (37%), Gaps = 10/178 (5%)
Query: 1012 DSSSKCSLYADSDGENDSTSD-----SESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEE 1066
DS + +S G ST++ E + + + S++ S S + E E
Sbjct: 170 DSGTYSVNATNSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHF 229
Query: 1067 EEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESP 1126
+ A + +P P +P P+ + SP P +A AR P+
Sbjct: 230 DARSIATVEMVIDGAAGQQLPHKTPPRIP-PKPKSRSPTPPSIAAKAQLARQQSPSPIRH 288
Query: 1127 PSAPLRPPEPPAGPPAPAPRPDERPS-SPIPLLPPPKKRRKTVSFSAIEVVPAPEPPP 1183
+P+R P P + P R S SPI + P RKT A V PE PP
Sbjct: 289 SPSPVRHVRAPTPSPVRSVSPAARISTSPIRSVRSPLLMRKT---QASTVATGPEVPP 343
Score = 37.7 bits (86), Expect = 0.096
Identities = 59/270 (21%), Positives = 99/270 (36%), Gaps = 32/270 (11%)
Query: 1146 RPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKF--PGPASRKAP-RG 1202
+P + P S +P+ P I VP E PP P P P +K P +
Sbjct: 8933 KPPDIPDSRVPIPTMP-----------IRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKR 8981
Query: 1203 VERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALT 1262
+E T + + D A V + P+E++ R ++ P T + A ++
Sbjct: 8982 IEVTKKAVKKD-AKKVVAKPKEMTP----------REEIVKKPPPPTTLIPAKAPEIIDV 9030
Query: 1263 PARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVP 1322
++ + + + + EA + H E + P P P
Sbjct: 9031 SSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVH--KEKRVFIESFEEPYDELEVEPYTEP 9088
Query: 1323 APAALFSSPADEV----LEAPEVVVAEAEEPKPQ-QLQQQREEGEEEGEEEGEEEEEESS 1377
+ P ++ +EA + V E EE + Q +REEG +EGEEE EE +E
Sbjct: 9089 FEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQERE 9148
Query: 1378 DSSSSSDGEGALRRRSLRSHARRRRPPPPP 1407
+ R + + ++ PPPP
Sbjct: 9149 VIQVQKEVYEESHERKVPAKVPEKKAPPPP 9178
Score = 37.7 bits (86), Expect = 0.096
Identities = 64/269 (23%), Positives = 86/269 (31%), Gaps = 66/269 (24%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPAS--EAPPPEPPEP 440
P EE P AE PP +P EP + + P EAPPP+ PEP
Sbjct: 10812 PEEEIAPEEEKPVPVAEEEEPEVPPPA---VPEEPKKIIPEKKVPVIKKPEAPPPKEPEP 10868
Query: 441 GG---------GGGGGGPSPEREEVRTS-------PRPASPARSGSPAP-ETTNESVPFA 483
P+P +E+V+ P+ P + P E T VP
Sbjct: 10869 EKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGG 10928
Query: 484 QHSSLDSRIEMLLKEQRSK-------FSFLASDTEEEEENSSMVLGARDTGSEVPSGSGH 536
+ ++ LL E++ + S L EEEE + VP
Sbjct: 10929 E-----KKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPE---- 10979
Query: 537 GPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPP 596
PPP P +V E R+ P+ + P P P
Sbjct: 10980 ---PPPPKPVEEVEVPTVTKRE----RKIPEPTKVPEIKPAI---------------PLP 11017
Query: 597 APTPPQQPP------PPPPPPPPPPPYLA 619
AP P +P PPP P P P A
Sbjct: 11018 APEPKPKPEAEVKTIKPPPVEPEPTPIAA 11046
Score = 35.4 bits (80), Expect = 0.48
Identities = 60/284 (21%), Positives = 86/284 (30%), Gaps = 28/284 (9%)
Query: 384 PRRATREEPPGAPFAENTAERFPPSY---TSYLPPEPSRPTDQDYRPPASEAPPPEPPEP 440
P++ EE P P E AE PP + PE +++ P +E PE P P
Sbjct: 10779 PKKPVLEEKPAVPVPER-AESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPP 10837
Query: 441 GGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQR 500
PE+ +V +P +P P PE E +
Sbjct: 10838 AVPEEPKKIIPEK-KVPVIKKPEAPPPK-EPEPEKVIEKPKLKPRPPPPPPAPPKEDVKE 10895
Query: 501 SKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGH-GPCTPPPAPANFEDVAPTGSGEP 559
F A ++ E + T +VP G P P E+V
Sbjct: 10896 KIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRK 10955
Query: 560 GATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPP---------PP 610
E PK + ++ + P P P P + P P
Sbjct: 10956 RPEEEEPKV------------EPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPE 11003
Query: 611 PPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654
P P ++PL P +P + PPP E P P P
Sbjct: 11004 PTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAP 11047
Score = 35.4 bits (80), Expect = 0.48
Identities = 52/225 (23%), Positives = 73/225 (32%), Gaps = 47/225 (20%)
Query: 414 PPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREE----VRTSPRPASPARSG 469
PP+ P +P PPP PP P P + +E ++ P+ P +
Sbjct: 10862 PPKEPEPEKVIEKPKLKPRPPPPPPAP--------PKEDVKEKIFQLKAIPKKKVPEKPQ 10913
Query: 470 SPAP-ETTNESVPFAQHSSLDSRIEMLLKEQRSK-------FSFLASDTEEEEENSSMVL 521
P E T VP + ++ LL E++ + S L EEEE
Sbjct: 10914 VPEKVELTPLKVPGG-----EKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKK 10968
Query: 522 GARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGD 581
+ VP PPP P +V PT + E K A P
Sbjct: 10969 LEKVKKPAVPE-------PPPPKPVEEVEV-PTVTKRERKIPEPTKVPEIKPAIPLP--- 11017
Query: 582 DMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYP 626
+P P P P + PPP P P + P+ P
Sbjct: 11018 -----------APEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVP 11051
Score = 33.9 bits (76), Expect = 1.4
Identities = 30/89 (33%), Positives = 36/89 (40%), Gaps = 31/89 (34%)
Query: 1127 PSAPLRPPEPPAGPPAPAPRPDERPSSPIPLL--------PPPKK---RRKTVSFSAIEV 1175
P+ P+R P PP AP PIPLL PPPK+ +K V A +V
Sbjct: 8945 PTMPIRAVPPEEIPPVVAP--------PIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKV 8996
Query: 1176 VPAPE------------PPPATPPQAKFP 1192
V P+ PPP T AK P
Sbjct: 8997 VAKPKEMTPREEIVKKPPPPTTLIPAKAP 9025
Score = 33.9 bits (76), Expect = 1.4
Identities = 25/79 (31%), Positives = 36/79 (45%), Gaps = 7/79 (8%)
Query: 1074 LPSASPPPREVP--VPTPAPVEVPVPERVAGSP----VTPLPEQEASPARPAGPTEESPP 1127
+P + PP E+P V P P+ +P PE P VT ++ + A P E +P
Sbjct: 8947 MPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAVKKDAKKVVAKPKEMTPR 9006
Query: 1128 SAPLRPPEPPAG-PPAPAP 1145
++ P PP PA AP
Sbjct: 9007 EEIVKKPPPPTTLIPAKAP 9025
Score = 33.5 bits (75), Expect = 1.8
Identities = 37/173 (21%), Positives = 58/173 (33%), Gaps = 15/173 (8%)
Query: 486 SSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGS----GHGPCTP 541
+ + S ++ + ++ +S L ++ E+ + V G + G
Sbjct: 142 AEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEEV-- 199
Query: 542 PPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPP 601
PA V+ E TR K A ++ +E+ D G P TPP
Sbjct: 200 -PAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIAT---VEMVIDGAAGQQLPHKTPP 255
Query: 602 QQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654
+ PP P P PP A L P+ P P P + P P P
Sbjct: 256 RIPPKPKSRSPTPPSIAAKAQLA-RQQSPS----PIRHSPSPVRHVRAPTPSP 303
Score = 33.1 bits (74), Expect = 2.4
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 1110 EQEASPARPAGPTEESPPSAPLRPPEPPAGPP 1141
E + ++P E P PL PPEPP+ PP
Sbjct: 30305 ENQFGISKPLKSEEPVTPKTPLNPPEPPSNPP 30336
Score = 32.7 bits (73), Expect = 3.1
Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 12/149 (8%)
Query: 991 EEAVDTTKKETEVSDGEDEESDSSS-KCSLYADSDGENDSTSDSESSSSSSSSSSSSS-- 1047
EE V K +T VS + ES + + + A D + +T + ++ +
Sbjct: 196 EEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLPHKTPP 255
Query: 1048 ----SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVP-ERVAG 1102
S S + S ++ ++ P+ + + P R V PTP+PV P R++
Sbjct: 256 RIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARIST 315
Query: 1103 SPV----TPLPEQEASPARPAGPTEESPP 1127
SP+ +PL ++ + A E PP
Sbjct: 316 SPIRSVRSPLLMRKTQASTVATGPEVPPP 344
Score = 31.6 bits (70), Expect = 6.9
Identities = 52/237 (21%), Positives = 74/237 (31%), Gaps = 48/237 (20%)
Query: 455 EVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEE- 513
EV P P+R+ P E E A H+ +M++ E++ F AS TEEE
Sbjct: 9208 EVSKKIVPQKPSRT--PVQEEVIEVKVPAVHTK-----KMVISEEKM---FFASHTEEEV 9257
Query: 514 -------------EENSSMVLGAR----DTGSEVPSGSGHGPCTPPPAPANFEDVAPTGS 556
EE + + R E+P P P P E AP
Sbjct: 9258 SVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAPVPIPKKVEPPAPKVP 9317
Query: 557 GEPGA-TRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPP--- 612
P E K + P + E+ P P ++ PP P
Sbjct: 9318 EVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQK 9377
Query: 613 ----------------PPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPP 653
PPP + +P P + + + PPPP+ P P P
Sbjct: 9378 GVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKP 9434
Score = 31.6 bits (70), Expect = 6.9
Identities = 39/146 (26%), Positives = 56/146 (38%), Gaps = 22/146 (15%)
Query: 239 NGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSS--------- 289
N P S ++ S SR S S YT + Q SA +S
Sbjct: 33170 NNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEE 33229
Query: 290 --------STTSTSFKPRRSENSYQDAFSRRH-----FSASSASTTASTAIAATTAATAS 336
++ TS + S S Q + S++ FS+SSAS+ A+ +A + S
Sbjct: 33230 PSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSASSMTEMKFASMSAQSMS 33289
Query: 337 SSASSSSLSSSSSSSSSSSSSQFRSS 362
S S SSSS S+ +Q SS
Sbjct: 33290 SMQESFVEMSSSSFMGISNMTQLESS 33315
Score = 31.2 bits (69), Expect = 9.0
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 8/63 (12%)
Query: 590 RGGSPPPA--PTPPQQPPPPPPPPP------PPPPYLASLPLGYPPHQPAYLLPPRPDGP 641
R SPPPA P ++ P P P PPPP + +LP P + + P
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKA 9450
Query: 642 PPP 644
PPP
Sbjct: 9451 PPP 9453
Score = 31.2 bits (69), Expect = 9.0
Identities = 16/39 (41%), Positives = 21/39 (53%)
Query: 1119 AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL 1157
AGP + SPPS P +P + P P PR + S+ I L
Sbjct: 14982 AGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIEL 15020
>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
Length = 707
Score = 97.4 bits (241), Expect = 1e-19
Identities = 48/124 (38%), Positives = 73/124 (58%), Gaps = 2/124 (1%)
Query: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
KK L S + WG+F +P+ +E + EY G+ I Q AD R K Y + S+LF
Sbjct: 572 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFLFN 629
Query: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
+++D ++DAT+ GN RF NH PNCYAKV+ + +I I++K+ I EE+ +DY++
Sbjct: 630 LNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 689
Query: 1687 PLED 1690
D
Sbjct: 690 SQAD 693
Score = 35.4 bits (80), Expect = 0.48
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 13/78 (16%)
Query: 1306 VKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEG 1365
+K P P R +P ++ S+P VLE+ + RE G E G
Sbjct: 304 IKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDT-------------DSDREAGTETG 350
Query: 1366 EEEGEEEEEESSDSSSSS 1383
E ++EEEE D +SSS
Sbjct: 351 GENNDKEEEEKKDETSSS 368
>gi|21361095 enhancer of zeste 2 isoform a [Homo sapiens]
Length = 751
Score = 97.4 bits (241), Expect = 1e-19
Identities = 48/124 (38%), Positives = 73/124 (58%), Gaps = 2/124 (1%)
Query: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
KK L S + WG+F +P+ +E + EY G+ I Q AD R K Y + S+LF
Sbjct: 616 KKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVY--DKYMCSFLFN 673
Query: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
+++D ++DAT+ GN RF NH PNCYAKV+ + +I I++K+ I EE+ +DY++
Sbjct: 674 LNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 733
Query: 1687 PLED 1690
D
Sbjct: 734 SQAD 737
Score = 35.4 bits (80), Expect = 0.48
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 13/78 (16%)
Query: 1306 VKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEG 1365
+K P P R +P ++ S+P VLE+ + RE G E G
Sbjct: 348 IKTPPKRPGGRRRGRLPNNSSRPSTPTINVLESKDT-------------DSDREAGTETG 394
Query: 1366 EEEGEEEEEESSDSSSSS 1383
E ++EEEE D +SSS
Sbjct: 395 GENNDKEEEEKKDETSSS 412
>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
Length = 747
Score = 97.1 bits (240), Expect = 1e-19
Identities = 49/124 (39%), Positives = 72/124 (58%), Gaps = 2/124 (1%)
Query: 1567 KKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFR 1626
KK L S + WG F E + +E + EY G+ I Q AD R K Y + SS+LF
Sbjct: 612 KKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVY--DKYMSSFLFN 669
Query: 1627 VDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKF 1686
+++D ++DAT+ GN RF NH PNCYAKV+ + +I I++K+ I EE+ +DY++
Sbjct: 670 LNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRY 729
Query: 1687 PLED 1690
D
Sbjct: 730 SQAD 733
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 96.7 bits (239), Expect = 2e-19
Identities = 93/319 (29%), Positives = 132/319 (41%), Gaps = 38/319 (11%)
Query: 906 ASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEG 965
+SE K P P + +P + G P + + E+ G + + S S G
Sbjct: 2510 SSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSS---SSSG 2566
Query: 966 EEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEV--------------SDGEDEES 1011
+S SSS E + E+E D++ + T + S S
Sbjct: 2567 SSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSS 2626
Query: 1012 DSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSE---SSSEDEEEE 1068
SSS S + S + S+S S SSSSSSSSSSSSSSSSSSSSSS+++ S S D+E
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAA 2686
Query: 1069 ERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPS 1128
P A PSA + +PT A + A SP P P ++PP
Sbjct: 2687 PAPTAGPSA-----QAALPTKATKQAGKARPSAHSPGKKTP----------APQPQAPPP 2731
Query: 1129 APLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQ 1188
P +P +P A A + RP +R +P KR++ S + A PA
Sbjct: 2732 QPTQPLQPKAQAGAKS-RPKKREGVHLPTTKELAKRQRLPSVENRPKIAA--FLPARQLW 2788
Query: 1189 AKFPGPASRKAPRGVERTI 1207
F P R+ +G R +
Sbjct: 2789 KWFGKPTQRRGMKGKARKL 2807
Score = 67.0 bits (162), Expect = 1e-10
Identities = 61/237 (25%), Positives = 108/237 (45%), Gaps = 11/237 (4%)
Query: 207 SGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQ 266
+G++ A + + D A P GN + + +++ SS +
Sbjct: 2508 AGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGS 2567
Query: 267 SSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTA 326
SS + +S GS ++ + R + A S S+SS+S+++S++
Sbjct: 2568 SSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSS 2627
Query: 327 IAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRR 386
++++++++SSS+SSSS SSSSSSSSSSSSS SS ++ + T
Sbjct: 2628 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS--------SSSSSTTDEDSSC 2679
Query: 387 ATREEPPGAPFAENTAERFPPSYTSYL--PPEPSRPTDQDYRP-PASEAPPPEPPEP 440
++ +E AP A +A+ P+ + PS + P P +APPP+P +P
Sbjct: 2680 SSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQP 2736
Score = 59.7 bits (143), Expect = 2e-08
Identities = 76/288 (26%), Positives = 99/288 (34%), Gaps = 54/288 (18%)
Query: 1099 RVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLL 1158
+ G L E + P+ P P S P PP A P RP+ P P
Sbjct: 2339 KAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSP 2398
Query: 1159 PPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLV 1218
PP A PAPE P A+ P PA+ AP PL
Sbjct: 2399 APP----------AFTSCPAPE------PFAELPAPATSLAP---------APLITMPAT 2433
Query: 1219 KSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLAD---LALTPARRGLPALPAVE 1275
+ P++ S A G R PG E +L V D + +++ AL E
Sbjct: 2434 RPKPKKARAAEESGAKGPRR--------PGEEAELLVKLDHEGVTSPKSKKAKEALLLRE 2485
Query: 1276 DSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEV 1335
D A + P+ LLS + PPA P+ P P A A E
Sbjct: 2486 DPGA----GGWQEPKSLLS-----------LGSYPPAAGSSEPK-APWPKATDGDLAQE- 2528
Query: 1336 LEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSS 1383
P + ++ PK Q ++G EE E SS SSSSS
Sbjct: 2529 -PGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSS 2575
Score = 59.3 bits (142), Expect = 3e-08
Identities = 85/336 (25%), Positives = 114/336 (33%), Gaps = 85/336 (25%)
Query: 897 RKEPSEISEASEEKRPRPSTPAEEDE------------DDPEQEKEA----GEPGRPGTK 940
R +P + A E P P EE E ++ KEA +PG G +
Sbjct: 2434 RPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQ 2493
Query: 941 PPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKD-EEDDEEDEEDEDREEAVDTTKK 999
PK G A S +A +++ D ++ ED K
Sbjct: 2494 EPKSLLSLGSYPP------AAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKA 2547
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSS------------------- 1040
+ E E+ ES SSS + +S S SSSSSS
Sbjct: 2548 QAEQDGAEESESSSSS-----------SSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCG 2596
Query: 1041 ----------------SSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREV 1084
+SSSSSSSSSSSSSSSSS SSS ++ S+S
Sbjct: 2597 TGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2656
Query: 1085 PVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAG-------PTEESPPSAPLRPPEPP 1137
+ + + + EA+PA AG PT+ + + RP
Sbjct: 2657 SSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHS 2716
Query: 1138 AGPPAPAPRPDERPSSPIPLLPP---------PKKR 1164
G PAP+P P P L P PKKR
Sbjct: 2717 PGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKR 2752
Score = 57.4 bits (137), Expect = 1e-07
Identities = 64/251 (25%), Positives = 105/251 (41%), Gaps = 51/251 (20%)
Query: 195 TGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTP---------CS- 244
+G +K Q E +ES SSS +++ + +++ G+ G C
Sbjct: 2538 SGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGT 2597
Query: 245 --QDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSE 302
++ S +SSR +P+S + SS + +S S+ S S+ SSS++S+S
Sbjct: 2598 GGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSS--SSSSSSSSSSSSSS------- 2648
Query: 303 NSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSS 362
S+SS+S +SSS+SSSS SSSSSSS++ S S
Sbjct: 2649 ------------SSSSSS--------------SSSSSSSSSSSSSSSSSTTDEDSSCSSD 2682
Query: 363 DANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTD 422
D PA + P +AT++ P A + ++ P PP+P++P
Sbjct: 2683 DEAAPAPTAG----PSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQ 2738
Query: 423 QDYRPPASEAP 433
+ A P
Sbjct: 2739 PKAQAGAKSRP 2749
Score = 47.0 bits (110), Expect = 2e-04
Identities = 88/381 (23%), Positives = 140/381 (36%), Gaps = 77/381 (20%)
Query: 926 EQEKEAGEP-------GRPGTKPPKRDEERGKT------QGKHRKSFALDSEGEEASQES 972
+ K AG P P T PK R + + + R SF+ DS E Q+
Sbjct: 1767 KNSKAAGGPKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFS-DSSEESFDQDE 1825
Query: 973 SSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEES----DSSSKCSLYADSDGEND 1028
SSE+++E++E +EEDE +E +S G +E + +L + + G +
Sbjct: 1826 SSEEEDEEEELEEEDEASGGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSL 1885
Query: 1029 STSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPT 1088
S E+ + S + + SE SE + + PA L P + + P
Sbjct: 1886 SVVQLEAKQKARKKEERQSLLGTEFEYTDSE--SEVKVRKRSPAGL---LRPKKGLGEPG 1940
Query: 1089 PAPVEVPVPERVAGSPVTP----LPEQEASPAR----PAGPTEESPPSAP---------- 1130
P+ + P P P +P L ++ AR P P E+ P A
Sbjct: 1941 PS-LAAPTPGARGPDPSSPDKAKLAVEKGRKARKLRGPKEPGFEAGPEASDDDLWTRRRS 1999
Query: 1131 --LRPPEPPAGPPAPAPRPDERPSSPI----PLLP-----------PPKKRRKTVSFSAI 1173
+ + A PAP +S PL P P+K++K
Sbjct: 2000 ERIFLHDASAAAPAPVSTAPATKTSRCAKGGPLSPRKDAGRAKDRKDPRKKKKGKEAGPG 2059
Query: 1174 EVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRA 1233
+P P PA P +A+ P +S A + S K+ +EV + R +
Sbjct: 2060 AGLPPPR-APALPSEARAPHASSLTAAK-------------RSKAKAKGKEVKKENRGKG 2105
Query: 1234 GGRGRLTE----EEEAEPGTE 1250
G +L E EE+ EP +
Sbjct: 2106 GAVSKLMESMAAEEDFEPNQD 2126
Score = 46.6 bits (109), Expect = 2e-04
Identities = 53/245 (21%), Positives = 84/245 (34%), Gaps = 30/245 (12%)
Query: 427 PPASEAPPPEPPEPGGGGG------GGGPSPEREEVRTSPRPASPARSGSPAPETTNESV 480
PPA+ + P+ P P G G G + E SP A + G+ E+++ S
Sbjct: 2505 PPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSS 2564
Query: 481 PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT 540
+ SS S S S+TE EEE G TG S + +
Sbjct: 2565 SGSSSSSSSS-------------SSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAAS 2611
Query: 541 PPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTP 600
P + ++ + + S ++ S ++ + +S SS S S + +
Sbjct: 2612 PASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2671
Query: 601 P-------QQPPPPPPPPPPPPPYLASLPLGYPPH----QPAYLLPPRPDGPPPPEYPPP 649
P P P A+LP +P+ P + P P+ PPP
Sbjct: 2672 TTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQAPPP 2731
Query: 650 PPPPP 654
P P
Sbjct: 2732 QPTQP 2736
Score = 45.1 bits (105), Expect = 6e-04
Identities = 95/441 (21%), Positives = 140/441 (31%), Gaps = 42/441 (9%)
Query: 527 GSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEIS 586
GSE P G P A A + A G P S + ++P S E
Sbjct: 2321 GSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPE-P 2379
Query: 587 DDDRGGSPPPAPTPPQQPPPPP--PPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPP- 643
D R +P P PPQ P PP P P P+ A LP PA L+ P P
Sbjct: 2380 VDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPF-AELPAPATSLAPAPLITMPATRPKPK 2438
Query: 644 -----PEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTR----LHQLR 694
E P P EL+ +L + P S + + +L R +
Sbjct: 2439 KARAAEESGAKGPRRPG-----EEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQ 2493
Query: 695 QGKGLIAASAGPPGGAFGEAFLPFPP------PQEAAYGL-------PYALYAQGQEGRG 741
+ K L++ + PP E P+P QE GL P + E G
Sbjct: 2494 EPKSLLSLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDG 2553
Query: 742 AYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQE 801
A E+ ++ SSS SG E E E + GT GR +
Sbjct: 2554 AEESESSSSSSSGSSSSSSSSSSSGSET-----EGEEEGDKNGDGGCGTGGRNCSAASSR 2608
Query: 802 MKS--IMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPG 859
S + + + + S + +++ + +
Sbjct: 2609 AASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2668
Query: 860 LLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVK---RKEPSEISEASEEKRPRPST 916
S D S + A A +G LP+ K + PS S + P+P
Sbjct: 2669 SSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQAGKARPSAHSPGKKTPAPQPQA 2728
Query: 917 PAEEDEDDPEQEKEAGEPGRP 937
P + + + +AG RP
Sbjct: 2729 PPPQPTQPLQPKAQAGAKSRP 2749
Score = 44.7 bits (104), Expect = 8e-04
Identities = 44/178 (24%), Positives = 65/178 (36%), Gaps = 15/178 (8%)
Query: 429 ASEAPPPEPPEPGGGGGGGG-PSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSS 487
+S E E G G GG + R S R ASPA S S + +++ S + SS
Sbjct: 2575 SSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSS 2634
Query: 488 LDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPAN 547
S S S +S + +SS + T + S P A +
Sbjct: 2635 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPS 2694
Query: 548 FEDVAPT-GSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQP 604
+ PT + + G R S + G+ +P + +PPP PT P QP
Sbjct: 2695 AQAALPTKATKQAGKARPSAHSPGKKTPAP-------------QPQAPPPQPTQPLQP 2739
Score = 43.1 bits (100), Expect = 0.002
Identities = 49/185 (26%), Positives = 67/185 (36%), Gaps = 24/185 (12%)
Query: 430 SEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLD 489
SE E + G GG G + R S R ASPA S S + +++ S + SS
Sbjct: 2579 SETEGEEEGDKNGDGGCG--TGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSS 2636
Query: 490 SRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFE 549
S S S +S + +SS + T + S P A + +
Sbjct: 2637 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQ 2696
Query: 550 DVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPP 609
PT AT+++ KA + SP G PAP P Q PPP P
Sbjct: 2697 AALPTK-----ATKQAGKAR-PSAHSP---------------GKKTPAPQP-QAPPPQPT 2734
Query: 610 PPPPP 614
P P
Sbjct: 2735 QPLQP 2739
Score = 41.6 bits (96), Expect = 0.007
Identities = 85/385 (22%), Positives = 128/385 (33%), Gaps = 68/385 (17%)
Query: 1050 SSSSSSSSSESSSEDEEEE---ERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPV- 1105
+ + + E++ +DE LP P P +P P P P P + V
Sbjct: 298 AEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAATPAGVY 357
Query: 1106 ---------------TPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDER 1150
T +P EA RP GP + + + R E AG P P
Sbjct: 358 TVFREQGREHRVVAPTFVPSVEAFDERP-GPIQIASQARDARAREREAGRPGVLQAP--- 413
Query: 1151 PSSPIPLLPPPKKRRKTVSFSAIEVVP------------APEPPPATP------PQAKFP 1192
P SP PL P R K +++ P +P+P P P+A P
Sbjct: 414 PGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKELLKPEAD-P 472
Query: 1193 GPASRKAPRG-----VERTIRNLPLDHASLVKSWPE------EVSRGGRSRAG------G 1235
P R APRG ++ + L+ + PE E+ ++
Sbjct: 473 RPCER-APRGPAGPAAQQAAKLFGLEPGRPPPTGPEHKWKPFELGNFAATQMAVLAAQHH 531
Query: 1236 RGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSH 1295
R EE + A L A+ P P + A S EA + L+ +
Sbjct: 532 HSRAEEEAAVVAASSSKKAYLDPGAVLPRSAATCGRPVADMHSAAHGSGEASAMQSLIKY 591
Query: 1296 ILLEHNYALAVKP-----TPPAPALRPPEPVPAPAALFSSPADEVLE---APEVVVAEAE 1347
A+AV+P P L +P PAP + +S A L P
Sbjct: 592 SGSFARDAVAVRPGGCGKKSPFGGLGTMKPEPAPTSAGASRAQARLPHSGGPAAGGGRQL 651
Query: 1348 EPKPQQLQQQREEGEEEGEEEGEEE 1372
+ P++ + + G E +GE E
Sbjct: 652 KRDPERPESAKAFGREGSGAQGEAE 676
Score = 40.0 bits (92), Expect = 0.019
Identities = 47/173 (27%), Positives = 64/173 (36%), Gaps = 19/173 (10%)
Query: 1267 GLPALPAVED---SEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPA 1323
GLPAL A ++ DE R +L + P PPAP PP P A
Sbjct: 292 GLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPPKGPPAPPAA 351
Query: 1324 -PAALFSSPADEVLEAPEV-------VVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEE 1375
PA +++ ++ E V V A E P P Q+ Q + E G +
Sbjct: 352 TPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIASQARDARAREREAGRPGVLQ 411
Query: 1376 SSDSSSSS-DGEGALRRRSLRSHARRRRPPPPPP-------PPPPRAYEPRSE 1420
+ S D LR ++ + +R PP P P PRAY P E
Sbjct: 412 APPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTVRATRASPDPRAYVPAKE 464
Score = 36.6 bits (83), Expect = 0.21
Identities = 107/472 (22%), Positives = 150/472 (31%), Gaps = 82/472 (17%)
Query: 1059 ESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPAR- 1117
E S+ E A L +A P +P P P G V+P P ASP
Sbjct: 948 EKGSKRGLEAAGKAGLATAGPGL----LPRKPPGLAAGPAGTYGKAVSPPPSPRASPVAA 1003
Query: 1118 ---------------PAGPTEESPPSAPLRPPEPPAGPPAPA-PRPDERPSSPIPLLPPP 1161
PA +P S P PP P + PP P R +E P + +
Sbjct: 1004 LKAKVIQKLEDVSKPPAYAYPATPSSHPTSPP-PASPPPTPGITRKEEAPENVVEKKDLE 1062
Query: 1162 KKRRKTVSFSAI-EVVPAPEPPPATPPQAKFPGP------------------------AS 1196
++ F A+ +P P A PP P P
Sbjct: 1063 LEKEAPSPFQALFSDIPPRYPFQALPPHYGRPYPFLLQPTAAADADGLAPDVPLPADGPE 1122
Query: 1197 RKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAV- 1255
R A ++ IR P ++ PEE R + E P E L +
Sbjct: 1123 RLALSPEDKPIRLSPSKITEPLREGPEEEPLAEREVKAEVEDMDEGPTELPPLESPLPLP 1182
Query: 1256 LADLALTPARRG--------LPALPAVEDS--EATETSDEAERPRPLL-SHILLEHNYA- 1303
A+ TP+ G AL A S E +E D E P P + S E A
Sbjct: 1183 AAEAMATPSPAGGCGGGLLEAQALSATGQSCAEPSECPDFVEGPEPRVDSPGRTEPCTAA 1242
Query: 1304 --LAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEG 1361
L V+ TP EPV P A+ P E + + E +P +
Sbjct: 1243 LDLGVQLTPETLVEAKEEPVEVPVAV---PVVEAVPEEGLAQVAPSESQPTLEMSDCDVP 1299
Query: 1362 EEEGEEEGEEE-------------EEESSDS--SSSSDGEGALRRRSLRSHARRRRPPPP 1406
EG+ E EE SSD S D + + + + RP P
Sbjct: 1300 AGEGQCPSLEPQEAVPVLGSTCFLEEASSDQFLPSLEDPLAGMNALAAAAELPQARPLPS 1359
Query: 1407 PPPPPPRAYEPRSEFEQMTILYDIWNSGLDSEDMSYLRLTYERLLQQTSGAD 1458
P +A E E + + + +++ L L ER Q+ GA+
Sbjct: 1360 PGAAGAQALEKLEAAESLVLEQSFLHGITLLSEIAELEL--ERRSQEMGGAE 1409
Score = 35.4 bits (80), Expect = 0.48
Identities = 64/310 (20%), Positives = 100/310 (32%), Gaps = 44/310 (14%)
Query: 327 IAATTAATASSSASSSSLSSSSSSSSSSSSS----QFRSSDAN----------YPAYYES 372
+A+ +ASS S L S S S + S+ Q ++ A+ YP+Y
Sbjct: 71 VASGMGPSASSHGSPVPLPSDLSFRSPTPSNLPMVQLWAAHAHEGFSHLPSGLYPSYL-- 128
Query: 373 WNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEA 432
+ H P + G P +T + P + P P P++
Sbjct: 129 ---HLNHLEPPSSGSPLLSQLGQPSIFDTQKGQGPGGDGFYLPTAGAPGSLHSHAPSART 185
Query: 433 PPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFA--QHSSLDS 490
P GGG G + R P R G P P + P A + +S
Sbjct: 186 P--------GGGHSSGAPAKGSSSRDGPAKERAGRGGEPPP-LFGKKDPRARGEEASGPR 236
Query: 491 RIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFED 550
+ L +E R+ E ++ L R + S + + P +
Sbjct: 237 GVVDLTQEARA---------EGRQDRGPPRLAERLSPFLAESKTKNAALQP-----SVLT 282
Query: 551 VAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPP 610
+ G+G+ G +A + + P P P P PPPP PP
Sbjct: 283 MCNGGAGDVGLPALVAEAGRGGAKEAARQDEGARLLRRTETLLPGPRPCPSPLPPPPAPP 342
Query: 611 PPPPPPYLAS 620
PP P A+
Sbjct: 343 KGPPAPPAAT 352
Score = 35.4 bits (80), Expect = 0.48
Identities = 33/110 (30%), Positives = 39/110 (35%), Gaps = 15/110 (13%)
Query: 511 EEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANG 570
E EE+ S L A +G G P PP A P + R SP A
Sbjct: 945 EMEEKGSKRGLEAAGKAGLATAGPGLLPRKPPGLAAGPAGTYGKAVSPPPSPRASPVA-- 1002
Query: 571 QNQASPCSSGDDMEISDDDRGGSPPPA----PTPPQQPPPPPPPPPPPPP 616
+A +D+ S PPA TP P PPP PPP P
Sbjct: 1003 ALKAKVIQKLEDV---------SKPPAYAYPATPSSHPTSPPPASPPPTP 1043
Score = 34.7 bits (78), Expect = 0.82
Identities = 60/243 (24%), Positives = 77/243 (31%), Gaps = 41/243 (16%)
Query: 385 RRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEP-PEPGGG 443
R AT EE +T PS T P P D+ + P + PP+P P P
Sbjct: 2344 RAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAF 2403
Query: 444 GGGGGPSPERE-----------------EVRTSPRPASPA-RSGSPAPETTNESVPFAQH 485
P P E R P+ A A SG+ P E
Sbjct: 2404 TSCPAPEPFAELPAPATSLAPAPLITMPATRPKPKKARAAEESGAKGPRRPGEEAELL-- 2461
Query: 486 SSLDSRIEMLLKEQRSKFSFLASDTEE----EEENSSMVLGARD--TGSEVPSG----SG 535
LD K +++K + L + +E S + LG+ GS P +
Sbjct: 2462 VKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLLSLGSYPPAAGSSEPKAPWPKAT 2521
Query: 536 HGPCTPPPAPA-NFEDVAPTGSGEP----GATRESPKANGQNQASPCSSGDDMEISDDDR 590
G P P FED SG P A E A +S SSG S
Sbjct: 2522 DGDLAQEPGPGLTFED-----SGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSS 2576
Query: 591 GGS 593
GS
Sbjct: 2577 SGS 2579
Score = 33.5 bits (75), Expect = 1.8
Identities = 17/34 (50%), Positives = 19/34 (55%), Gaps = 5/34 (14%)
Query: 591 GGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLG 624
G P P+P PP PP PP PP PP A+ P G
Sbjct: 327 GPRPCPSPLPP--PPAPPKGPPAPP---AATPAG 355
Score = 33.5 bits (75), Expect = 1.8
Identities = 39/145 (26%), Positives = 62/145 (42%), Gaps = 19/145 (13%)
Query: 1284 DEAERPRPLLSHI-LLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVV 1342
D+ + R LSHI LL +Y ++ P+PAL VP+ + + E +
Sbjct: 2265 DDGDTGRIPLSHIRLLPPDYK--IQCAEPSPALL----VPSAKRRSRKTSKDTGEGKDGG 2318
Query: 1343 VAEAEEPKPQQLQQQRE-EGEEEGE-----EEGEEEEEESSD------SSSSSDGEGALR 1390
A +EEP + + R+ + +G+ EEG +E S SS+ +
Sbjct: 2319 TAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTPGSKKSPPE 2378
Query: 1391 RRSLRSHARRRRPPPPPPPPPPRAY 1415
R+ A + RP PP P P P A+
Sbjct: 2379 PVDKRAKAPKARPAPPQPSPAPPAF 2403
Score = 32.7 bits (73), Expect = 3.1
Identities = 22/64 (34%), Positives = 24/64 (37%), Gaps = 3/64 (4%)
Query: 596 PAPTPPQQPPPPPPPPPPPPPYLASL---PLGYPPHQPAYLLPPRPDGPPPPEYPPPPPP 652
PA T + PPP P P L + L PAY P P P P PPP
Sbjct: 982 PAGTYGKAVSPPPSPRASPVAALKAKVIQKLEDVSKPPAYAYPATPSSHPTSPPPASPPP 1041
Query: 653 PPHI 656
P I
Sbjct: 1042 TPGI 1045
Score = 31.6 bits (70), Expect = 6.9
Identities = 36/161 (22%), Positives = 60/161 (37%), Gaps = 24/161 (14%)
Query: 990 REEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSS 1049
R+ + DT + + + G +E + + + D + E + + S+ +
Sbjct: 2305 RKTSKDTGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLAL 2364
Query: 1050 SSSSSSSSSESSSEDEEEEERPAALPSASP-PPREVPVPT--------------PAPVEV 1094
SS+ S +S E ++ A P A P PP+ P P PAP
Sbjct: 2365 EPSSTPGSKKSPPEPVDKR---AKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPA-- 2419
Query: 1095 PVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPE 1135
+A +P+ +P P + A EES P RP E
Sbjct: 2420 ---TSLAPAPLITMPATRPKP-KKARAAEESGAKGPRRPGE 2456
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 91.3 bits (225), Expect = 7e-18
Identities = 102/484 (21%), Positives = 182/484 (37%), Gaps = 28/484 (5%)
Query: 944 RDEERGKTQGKHRKSFALDSEGEEASQ--------ESSSEKDEEDDEEDEEDEDREEAVD 995
+ EE+ K K K + E E +Q E K+EE EE+ +E+ E +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 996 TTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSS-SSSSSSSSSSSSSS 1054
K + E ++ S A S E S E+ S + S + S + +
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 1055 SSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEAS 1114
S E+ S ++EE + PA + S +P E PE+ +P+ E+ S
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK----SPVKEEAKS 614
Query: 1115 PARPAGPT-EESPPSAPLRPPEPPAGPPAPAPRPDERPSSP-IPLLPPPKKRRKTVSFSA 1172
PA P EE+ A ++ PE P + E+ SP P+K + V A
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 1173 IEVVPAPEPPPA---TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGG 1229
A P A +P +AK P K+P + ++ EE
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 1230 RSRAGGRGRLTEEEEAE-PGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAER 1288
++++ + E+A+ P L V + A TPA+ + PA + E ++ + E
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS-PADKFPEKAKSPVKEEV 793
Query: 1289 PRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEE 1348
P + L+ + K P E V +P P + ++ P E +
Sbjct: 794 KSPEKAKSPLKEDAKAPEKEIP------KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 1349 PKPQQLQQQREEGEEEG--EEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPP 1406
P + +++++ +EE +E + + EE + + E + + + +++ P P
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 1407 PPPP 1410
P
Sbjct: 908 KEAP 911
Score = 88.6 bits (218), Expect = 5e-17
Identities = 98/471 (20%), Positives = 184/471 (39%), Gaps = 43/471 (9%)
Query: 975 EKDEED----DEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDST 1030
EK E++ +E+ EE + EE + +KE + +G++EE +++G + T
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEE------EAEGGEEET 501
Query: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAAL--PSASPPPREVPVPT 1088
S + ++S + S + S +E+ S ++EE + PA + P + P + +
Sbjct: 502 K-SPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 1089 PAPVEVPVPERVAGSPVTPLPEQEASPARPAG--PTEESPPSAPLRPPEPPAGPPAPAPR 1146
P + P E PE+ SPA+ P E P P + A PA A
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKS 620
Query: 1147 P-DERPSSPIPLLPPPKKRRKTVSFS-AIEVVPAPEPPPA-TPPQAKFPGPASRKAPRGV 1203
P E SP + P K + T + + E +PE A +P +AK P A K+P
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Query: 1204 ERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTP 1263
+ ++ EE ++++ + E+A+ + + A TP
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE-------AKTP 733
Query: 1264 ARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPA 1323
+ P E ++ ++A+ P + + K +PA + PE +
Sbjct: 734 EKAKSPV------KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 1324 PAA-------LFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEES 1376
P SP E +APE + + EE K ++++ + + E + EEE++
Sbjct: 788 PVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 1377 -----SDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFE 1422
++ S E A ++ + + ++ P P + + E E
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898
Score = 82.4 bits (202), Expect = 3e-15
Identities = 129/569 (22%), Positives = 216/569 (37%), Gaps = 57/569 (10%)
Query: 898 KEPSEISEASEEKRPRPSTPAEEDEDDPEQ--EKEAGEPGRPGTKPPKRDEERGKTQGKH 955
+E +E ++ +EE A+E+E E+ E+E E G TK P +E + K
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEE--AASPEKE 515
Query: 956 RKSFALDSEGEEASQESSSEKDEEDD--EEDEEDEDREEAVDTTKKETEVSDGEDEESDS 1013
KS + E + ++ S EK+E E ++ + A + K E E EE+ S
Sbjct: 516 AKS-PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574
Query: 1014 SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAA 1073
++ + + S + + S + S + S +E+ S +EE + PA
Sbjct: 575 PAEVK---SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
Query: 1074 LPSA----SPPPREVPVP----TPAPVEVPVPERVAGSPV---TPLPEQEASPARPAGPT 1122
+ S SP E P +P E PE+ A SPV PE+ SP + +
Sbjct: 632 VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEK-AKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 1123 EE---SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL-LPPPKKRRKTVSFSAIEVVPA 1178
E SP + PE P + E+ SP+ P+K + V A A
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 1179 PEPPPATP-----PQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGR--S 1231
P A P+AK P ++P P+ VKS PE+ + +
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE--VKS-PEKAKSPLKEDA 807
Query: 1232 RAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRP 1291
+A + +EE P E + + P + PA +E + S + E P+
Sbjct: 808 KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKK 867
Query: 1292 LLSHILLEHNYALAV-KPTPPAPALRPPE-------PVP---APAALFSSPADEVLEAPE 1340
+E AV KP + E P P APA + + E E
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE 927
Query: 1341 VVV-----AEAEEP-KPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSL 1394
V A+A+EP KP + ++ E ++ EE+ ++ EE+ + + + + L +
Sbjct: 928 VAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPS 987
Query: 1395 RSHARRRR----PPPPPPPPPPRAYEPRS 1419
+ A + PP +A E ++
Sbjct: 988 KPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Score = 77.4 bits (189), Expect = 1e-13
Identities = 132/669 (19%), Positives = 232/669 (34%), Gaps = 70/669 (10%)
Query: 730 YALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSV---SGEEARLPPREEAE--LAEGKT 784
Y +G+E R + + LP + P S+ + S E+ ++ + E E + E +T
Sbjct: 402 YRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT 461
Query: 785 LPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQ 844
T T V +E K ++ E G + EE A P + AK
Sbjct: 462 EETQVTE-EVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASP-EKEAKSP 519
Query: 845 AKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEIS 904
KEE K + K P + AKS A A P K KE E
Sbjct: 520 VKEEAKSPAEAKSPEK----EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKE--EAK 573
Query: 905 EASEEKRP-RPSTPAEEDEDDPEQEK---EAGEPGRPGTKPPKRDEERGKTQGKHRKSFA 960
+E K P + +PA+E+ P + K +A P + K P + K + K
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633
Query: 961 LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020
+ + ++E + ++ E EE + E+A K E + + + +K
Sbjct: 634 SPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693
Query: 1021 ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP 1080
A S + ++ S ++ S + S + S + +E + A P
Sbjct: 694 AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Query: 1081 PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE---SPPSAPLRPPEP- 1136
+ + +P + A SP PE+ SP + + E SP + PE
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
Query: 1137 -PAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPA 1195
P +P +E + + PPKK + E PATP +
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE-------------EKAPATPKTEEKKDSK 860
Query: 1196 SRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAV 1255
+AP+ + P K E + + A ++EEAE +V
Sbjct: 861 KEEAPK------KEAPKPKVEEKKEPAVEKPKESKVEA-------KKEEAEDKKKVP--- 904
Query: 1256 LADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPAL 1315
TP + + ED++ E ++ A++ E + A A +P+ PA
Sbjct: 905 ------TPEKEAPAKVEVKEDAKPKEKTEVAKK----------EPDDAKAKEPSKPA--- 945
Query: 1316 RPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEE 1375
E P A + E P+ E+ K + + + E+ + ++++
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Query: 1376 SSDSSSSSD 1384
++ D
Sbjct: 1006 KPPEKATED 1014
Score = 58.9 bits (141), Expect = 4e-08
Identities = 121/603 (20%), Positives = 213/603 (35%), Gaps = 73/603 (12%)
Query: 494 MLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAP 553
++++EQ + TEEEE+ + G + G E G T P PA E+ A
Sbjct: 455 VIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP-PA--EEAA- 510
Query: 554 TGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPP 613
P +SP + S + E SP A +P ++ PP
Sbjct: 511 ----SPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 614 PPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQW 673
P A P + A P + + P E P + + S
Sbjct: 567 PEKEEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPEKAKSPVKEEAKSP---------- 615
Query: 674 GGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALY 733
+ + + + + K A P A P++A P
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS--PVKAE 673
Query: 734 AQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPT---AGT 790
A+ E + + P A P+ + S E+A+ P +EEA+ E P A T
Sbjct: 674 AKSPEKAKSPVKAEAKSP-EKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 791 VGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKP---FQNAAKQQAKE 847
+ + + +E KS ++ + + + + + + +KEE P F AK KE
Sbjct: 733 PEKAKSPVKEEAKS-PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE 791
Query: 848 EDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKR---------- 897
E K K K P L + AK+ + S ++ + KVK
Sbjct: 792 EVKSPEKAKSP----LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 898 --------KEPSEISEASEEKRPRPSTPAEED-------EDDPEQEKEAGEPGRPGTKPP 942
K+ S+ EA +++ P+P +++ E E +KE E + P
Sbjct: 848 PATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPE 907
Query: 943 KRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETE 1002
K E K + K D++ +E ++ + E D+ +E + +++EA K E
Sbjct: 908 K--EAPAKVEVKE------DAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKE 959
Query: 1003 VSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSS 1062
+ EE + ++ + D + S+ S + + SSS+ S E ++
Sbjct: 960 EKAKKPEEKPKT-------EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKAT 1012
Query: 1063 EDE 1065
ED+
Sbjct: 1013 EDK 1015
Score = 41.2 bits (95), Expect = 0.009
Identities = 96/514 (18%), Positives = 168/514 (32%), Gaps = 42/514 (8%)
Query: 390 EEPPGAPFAENTAE-----RFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGG 444
EE +P AE A + P + P E P ++ + PA P + P
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 445 GGGGP---SPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRS 501
P SPE+EE ++ SP ++ SPA E S + KE+
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV----KEEAK 613
Query: 502 KFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPP------------APANFE 549
+ S +EE ++ + V S + P +P E
Sbjct: 614 SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Query: 550 DVAPTGSGEP-GATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPP 608
+P + P A +SP+ S + + + SP A +P ++ P
Sbjct: 674 AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733
Query: 609 PPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDR 668
P A P + A L + P P + S +
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793
Query: 669 LGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGL 728
+ P+ + + + + K + P E P +E A
Sbjct: 794 KSPEKAKSPLKEDAKAPE-KEIPKKEEVKSPVKEEEKPQEVKVKEP--PKKAEEEKAPAT 850
Query: 729 PYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTA 788
P + + A +EA P P E + +E+++ ++E E + K +PT
Sbjct: 851 PKTEEKKDSKKEEAPKKEA---PKPKVEEKKEPAVEKPKESKVEAKKE-EAEDKKKVPTP 906
Query: 789 GTVGRVLAMLVQEMKSIMQRDLNRKMVENVAF----------GAFDQWWESKEEKAKPFQ 838
+ ++ K + ++ +K ++ A + ++KEEKAK +
Sbjct: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE 966
Query: 839 NAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGT 872
K +AK ++ +KT KEP KS T
Sbjct: 967 EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 32.7 bits (73), Expect = 3.1
Identities = 40/218 (18%), Positives = 79/218 (36%), Gaps = 20/218 (9%)
Query: 282 SQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASS 341
S + A S + P ++A S + + + + A + A S +
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAK 605
Query: 342 SSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENT 401
S + + S + + S +A PA +S + + P + + P A E
Sbjct: 606 SPVKEEAKSPAEAKSPV--KEEAKSPAEVKSPEKAKS-----PTKEEAKSPEKAKSPEKE 658
Query: 402 AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPR 461
+ P S + E P ++ P +EA PE + SP +EE ++ +
Sbjct: 659 EAKSPEKAKSPVKAEAKSP-EKAKSPVKAEAKSPEKAK----------SPVKEEAKSPEK 707
Query: 462 PASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQ 499
SP + + +PE P + + + + +KE+
Sbjct: 708 AKSPVKEEAKSPEKAKS--PVKEEAKTPEKAKSPVKEE 743
>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
sapiens]
Length = 1362
Score = 90.9 bits (224), Expect = 1e-17
Identities = 122/531 (22%), Positives = 183/531 (34%), Gaps = 130/531 (24%)
Query: 894 KVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQG 953
K KRKE E ++ S+ K P P + + + K+ P + P EE K +
Sbjct: 550 KHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKP 609
Query: 954 ---KHRKSFALDSE---GEEASQE----SSSEKDEEDDEEDEEDEDREEAVDTTKKETE- 1002
+ ++ +LD GE+ + S E ++ DE + D E +T +E E
Sbjct: 610 MSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELER 669
Query: 1003 --VSDGEDEESDSSSKCSLYADSDG-ENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSE 1059
S + + K + A S + S+S+SESSS SSSS S S + + S
Sbjct: 670 YVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKG 729
Query: 1060 SSSEDEEE---------EERPAALPSASPPPREVPVPTPAP------------------- 1091
++++ ++ PA +P PPP + P P P P
Sbjct: 730 HPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQA 789
Query: 1092 -------------VEVPVPE-RVAGS----------PVTPLPEQEASPARPAGPTEESPP 1127
+VPV E ++ GS P+ LP+ E P P P +PP
Sbjct: 790 APAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPP 849
Query: 1128 SAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPP 1187
P P+ RPS+ LPP R VS + + P+PP A PP
Sbjct: 850 HLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPP 909
Query: 1188 QAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEE--A 1245
Q L E+EE A
Sbjct: 910 QV-------------------------------------------------LLEDEEPPA 920
Query: 1246 EPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALA 1305
P T + + + L + P LP+V + + P P H ++ L
Sbjct: 921 PPLTSMQMQLYLQ-QLQKVQPPTPLLPSV------KVQSQPPPPLPPPPHPSVQQQ--LQ 971
Query: 1306 VKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQ 1356
+P PP PP+P P P P V P ++P P Q QQ
Sbjct: 972 QQPPPPP----PPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQ 1018
Score = 84.0 bits (206), Expect = 1e-15
Identities = 92/350 (26%), Positives = 123/350 (35%), Gaps = 45/350 (12%)
Query: 335 ASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRA-TREEPP 393
+SS + SSS SSSS S S + +S +P + + + H A ++PP
Sbjct: 699 SSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPP 758
Query: 394 GAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPP----------EPPEPGGG 443
P + PP PP P P+ PA ++ PP EP PG
Sbjct: 759 PPP--QQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSV 816
Query: 444 GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDS-RIEMLLKEQRSK 502
G + + P+P P P +T + QH+ + + L +Q S+
Sbjct: 817 FDPIGHFTQ--PILHLPQPELPPHLPQPPEHSTPPHLN--QHAVVSPPALHNALPQQPSR 872
Query: 503 FSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGAT 562
S A+ + V A +P P P ED P
Sbjct: 873 PSNRAAALPPKPARPPAVSPALTQTPLLPQ-----PPMAQPPQVLLEDEEPPAPPLTSMQ 927
Query: 563 RESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPP---------QQPPPPPPPPPP 613
+ Q P +++ PPP P PP QQPPPPPPP P
Sbjct: 928 MQLYLQQLQKVQPPTPLLPSVKVQSQP----PPPLPPPPHPSVQQQLQQQPPPPPPPQPQ 983
Query: 614 PPPYLASLPLGYPPH-QPAYL-----LPPRPDGPPPPEYPP---PPPPPP 654
PPP P P H QP PP P G PP PP PPPP P
Sbjct: 984 PPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQP 1033
Score = 82.8 bits (203), Expect = 3e-15
Identities = 128/585 (21%), Positives = 203/585 (34%), Gaps = 108/585 (18%)
Query: 887 ALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDE 946
A RL + + K E A + + E+D+ + ++EK + K K E
Sbjct: 508 AQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKE 567
Query: 947 ERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDE-----EDEDREEAVDTTK--- 998
K K+ S + S+ E A +S E +EED+ +E R+ ++D K
Sbjct: 568 PPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPG 627
Query: 999 ----KETEVSDGEDEESDSSSKCSLYADSDGENDST-------------------SDSES 1035
+ + + +S+ + D + ST ++
Sbjct: 628 EKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVD 687
Query: 1036 SSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPRE-----------V 1084
+ SS SSS S SSS SS S SED E E P + P +
Sbjct: 688 VIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQ 747
Query: 1085 PVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPA 1144
P P P + P P + P P P+Q+ P P P +AP PP P
Sbjct: 748 QAPAPVPQQPPPPPQ--QPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPP--PFIAT 803
Query: 1145 PRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVE 1204
P P P + P + + +P PE PP P + P P +
Sbjct: 804 QVPVLEPQLPGSVFDPIGHFTQPILH-----LPQPELPPHLPQPPEHSTP-----PHLNQ 853
Query: 1205 RTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPA 1264
+ + P H +L P++ SR R + A P A++PA
Sbjct: 854 HAVVSPPALHNAL----PQQ-----PSRPSNRAAALPPKPARPP-----------AVSPA 893
Query: 1265 RRGLPALPAVEDSEATET-SDEAERPRPLLSHILLEHNYALAVKPTPPAPAL-------R 1316
P LP ++ + ++ E P P L+ + ++ K PP P L +
Sbjct: 894 LTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQ 953
Query: 1317 PPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEES 1376
PP P+P P S ++ + P +P PQQ Q + + S
Sbjct: 954 PPPPLPPPP--HPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVH------LQPMQFS 1005
Query: 1377 SDSSSSSDGEGALRRRSLRSHARRRRPPPPPP---PPPPRAYEPR 1418
+ +G ++PP PPP PPPP+ +P+
Sbjct: 1006 THIQQPPPPQG-------------QQPPHPPPGQQPPPPQPAKPQ 1037
Score = 62.4 bits (150), Expect = 4e-09
Identities = 93/443 (20%), Positives = 147/443 (33%), Gaps = 110/443 (24%)
Query: 1071 PAALPSASPPPREVPVPTPAPVEVPVPERVAGSP--VTPLPEQEASPARPAGPTEESPPS 1128
P +++PP + P P P PV+ A +P + P P +P ++PP
Sbjct: 197 PNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPL----QTPPP 252
Query: 1129 APLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAP-----EPP- 1182
P +P PPA PAP+P + I P P K +K V A P EPP
Sbjct: 253 VPPQPQPPPA----PAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPS 308
Query: 1183 ------------------PATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVK----- 1219
P PP+ P AP + L L +
Sbjct: 309 LPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKK 368
Query: 1220 ----SWPE---------------EVSRGGRSRAGGRGRLTEEE---EAEPGTEVDLAVLA 1257
+WP ++ + + + +L E E G +V L
Sbjct: 369 HAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSN 428
Query: 1258 DLALTPARRGLPA----LPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAP 1313
P + A L V + + DE E P +S +P
Sbjct: 429 CYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVS-----------------SP 471
Query: 1314 ALRPPEPVPAPAALFSSPAD------------------------EVLEAPEVVVAEAEEP 1349
A+ PP V AP + S +D E L+A +A +P
Sbjct: 472 AVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQP 531
Query: 1350 ---KPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPP 1406
KP++ ++ ++E ++E + EE EE + + + S S+ ++ P P
Sbjct: 532 QQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPM 591
Query: 1407 PPPPPPRAYEPRSEFEQMTILYD 1429
PPP YE E + + Y+
Sbjct: 592 KSKPPP-TYESEEEDKCKPMSYE 613
Score = 58.2 bits (139), Expect = 7e-08
Identities = 78/395 (19%), Positives = 132/395 (33%), Gaps = 63/395 (15%)
Query: 315 SASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWN 374
+ SS + T + A +++ SSS SSS SS+ S + + A +E
Sbjct: 467 AVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLA 526
Query: 375 RYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYL---PPEPSRPTDQDYRPPASE 431
+ P++ +++ E + S PP+ ++ + + +
Sbjct: 527 ALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKK 586
Query: 432 APPPEPPEPGGGGGGGGPSPEREEVRTSPRPAS--------------PARSGSPAPETTN 477
P P +P P+ E EE +P S P
Sbjct: 587 EPAPMKSKPP-------PTYESEE-EDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQ 638
Query: 478 ESVPFAQHSSLDS--------RIEMLLKEQRSKFSFLASDTEEEEENSSMVLGA-RDTGS 528
P ++S+ D + L + +R S L + + E ++ G+ + G
Sbjct: 639 SREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGF 698
Query: 529 EVPSGSGHGPCTPPPAPANFEDVAPTGS--GEPGATRESPKANGQNQASPCSSGDDMEIS 586
+ + + ++AP G PG RE K + + + +
Sbjct: 699 SSSESESSSESSSSDSEDSETEMAPKSKKKGHPG--REQKKHHHHHHQQMQQAPAPVPQQ 756
Query: 587 DDDRGGSPPPAPTPPQQPPPPPPPPPP-------------PPPYLASLPLGYPPHQPAYL 633
PPP P P QQ PPPPPPPP PPP++A+ P P +
Sbjct: 757 PPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSV 816
Query: 634 LP------------PRPDGPPPPEYPPPPPPPPHI 656
P+P+ PP PP PPH+
Sbjct: 817 FDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHL 851
Score = 51.6 bits (122), Expect = 6e-06
Identities = 71/338 (21%), Positives = 119/338 (35%), Gaps = 61/338 (18%)
Query: 1066 EEEERPAALPSASPP-PREVPVPTPAPVEVPV-PERVAGSPVTPLPEQEASPARPAGPTE 1123
++ RP+ +A PP P P +PA + P+ P+ P L E E PA P +
Sbjct: 868 QQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQ 927
Query: 1124 -----------------------ESPPSAPLRPPE------------PPAGPPAPAPRPD 1148
+S P PL PP PP PP P P P
Sbjct: 928 MQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQ 987
Query: 1149 ERPSSPIPLLPPPKKRRKTVSFSAIEVVPAP--EPPPATPPQAKFPGPASRKAPRGVERT 1206
++ P P P + + I+ P P + PP PP + P P K + ++
Sbjct: 988 QQHQPP----PRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQH- 1042
Query: 1207 IRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARR 1266
+ P H KS P G R + + + + P ++
Sbjct: 1043 -HHSPRHH----KSDPYST---GHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQ 1094
Query: 1267 GLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAA 1326
L A V+ +E + S I+ ++ +++P PP + PE + AP
Sbjct: 1095 ELRAASVVQPQPLVVVKEE-----KIHSPIIRSEPFSPSLRPEPP----KHPESIKAPVH 1145
Query: 1327 LFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEE 1364
L P + ++ V+ E+ P +++ ++E
Sbjct: 1146 LPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQE 1183
Score = 51.2 bits (121), Expect = 8e-06
Identities = 113/581 (19%), Positives = 197/581 (33%), Gaps = 141/581 (24%)
Query: 906 ASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEG 965
+S + S+ ++ DD E+E+ + E + + + H + AL
Sbjct: 484 SSSDSSSDSSSDSDSSTDDSEEERAQ-----------RLAELQEQLKAVHEQLAALS--- 529
Query: 966 EEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDG 1025
+ Q +K+++ E+ +E R+E V+ KK S ++ + K
Sbjct: 530 -QPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKK----SKAKEPPPKKTKK--------- 575
Query: 1026 ENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE------------------ 1067
N+S++ + S + S + S + S +E+
Sbjct: 576 -NNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVV 634
Query: 1068 ---EERPAALPSASPPPREVPVPTPAPVEVPVPER-------------------VAG-SP 1104
+ R +L +++P E+ T P + ER +AG S
Sbjct: 635 HIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSK 694
Query: 1105 VTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPP-----------------APAPRP 1147
+ E+ + + ++ + P G P APAP P
Sbjct: 695 MKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVP 754
Query: 1148 DERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTI 1207
+ P P PPP +++ + P P PPP+ P QA PA + +P T
Sbjct: 755 QQPPPPPQQPPPPPPPQQQ-------QQPPPPPPPPSMPQQA---APAMKSSPPPFIAT- 803
Query: 1208 RNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRG 1267
+P+ L S + + G T+ P E+
Sbjct: 804 -QVPVLEPQLPGSVFDPI-----------GHFTQPILHLPQPELP--------------- 836
Query: 1268 LPALP-AVEDSEATETSDEAERPRPLLSHILLEH-----NYALAVKPTPPAPALRPPEPV 1321
P LP E S + A P L + L + N A A+ PP PA RPP
Sbjct: 837 -PHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAAL---PPKPA-RPPAVS 891
Query: 1322 PAPAALFSSPADEVLEAPEVVVAEAEEPKP--QQLQQQREEGEEEGEEEGEEEEEESSDS 1379
PA P + + P+V++ + E P P +Q Q + + +
Sbjct: 892 PALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQ 951
Query: 1380 SSSSDGEGALRRRSLRSHARRRRPPPPPP---PPPPRAYEP 1417
S S++ +++ PPPPPP PPP + ++P
Sbjct: 952 SQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQP 992
Score = 47.0 bits (110), Expect = 2e-04
Identities = 30/108 (27%), Positives = 39/108 (36%), Gaps = 6/108 (5%)
Query: 553 PTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPP 612
PT E + + G+ + G + + + +PP TP PPP P
Sbjct: 165 PTEETEIMIVQAKGRGRGRKETGTAKPGVST-VPNTTQASTPPQTQTPQPNPPPVQATPH 223
Query: 613 PPPPYLASLPLGYP-----PHQPAYLLPPRPDGPPPPEYPPPPPPPPH 655
P P L + P P QP PP P P PP P P P H
Sbjct: 224 PFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSH 271
Score = 45.8 bits (107), Expect = 4e-04
Identities = 139/687 (20%), Positives = 232/687 (33%), Gaps = 110/687 (16%)
Query: 451 PEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDT 510
P+ E+V + S E+++ES + S DS EM K ++
Sbjct: 681 PQAEKVDVIAGSSKMKGFSSSESESSSES---SSSDSEDSETEMAPKSKKKGHPGREQKK 737
Query: 511 EEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANG 570
+ M + + VP P PPP P + P P + + A
Sbjct: 738 HHHHHHQQM----QQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQA-APA 792
Query: 571 QNQASPCSSGDDMEISDDDRGGS---------PPPAPTPPQQPPP--PPPPPPPPPPYLA 619
+ P + + + GS P P + PP P PP PP+L
Sbjct: 793 MKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLN 852
Query: 620 SLPLGYP-------PHQP------AYLLPPRPDGP---------------PPPEYPP--- 648
+ P P QP A LPP+P P PP PP
Sbjct: 853 QHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVL 912
Query: 649 -----PPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRL----HQLRQGKGL 699
PP PP L+ + ++ +P S ++Q+Q L H Q +
Sbjct: 913 LEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLP-SVKVQSQPPPPLPPPPHPSVQQQLQ 971
Query: 700 IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPL 759
PP P PPPQ+ P ++ Q + +S P P +P
Sbjct: 972 QQPPPPPPP-------QPQPPPQQQHQPPPRPVHLQPMQ----FSTHIQQPPPPQGQQP- 1019
Query: 760 PSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVA 819
P + P + ++ + P ++E S + M+ +
Sbjct: 1020 PHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPL-------MIHSPQ 1072
Query: 820 FGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFA 879
F +S ++ P QN Q K+++ + +P L +V K I +
Sbjct: 1073 MSQF----QSLTHQSPPQQNV---QPKKQELRAASVVQPQPLVVVKEEKIHSPI-IRSEP 1124
Query: 880 FGSGLRGALRLPSFKVKRKEPSEISEASEEK-----RP--RPSTPAEEDEDDPEQEKEAG 932
F LR P K P + + E K RP RP P+++K+
Sbjct: 1125 FSPSLRP--EPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQ 1182
Query: 933 EPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREE 992
EP P PK+D + K G ++ +SSS+ E+ E E+RE+
Sbjct: 1183 EPKTP--VAPKKD-LKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREK 1239
Query: 993 AV----DTTKKETE------VSDGEDEES-DSSSKCSLYADSDGENDSTSDSESSSSSSS 1041
A+ + +KE E + EDE++ + + + A E E
Sbjct: 1240 ALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQ 1299
Query: 1042 SSSSSSSSSSSSSSSSSESSSEDEEEE 1068
+++ +++++ + SS S D++ E
Sbjct: 1300 QAAAVAAAATPQAQSSQPQSMLDQQRE 1326
Score = 38.9 bits (89), Expect = 0.043
Identities = 35/161 (21%), Positives = 56/161 (34%), Gaps = 35/161 (21%)
Query: 1034 ESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVE 1093
E+ ++ S+ +++ +S+ + + P P+ +P ++ V TP
Sbjct: 185 ETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTP---DLIVQTPVMTV 241
Query: 1094 VPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSS 1153
VP PV P P+ PPAPAP+P +
Sbjct: 242 VPPQPLQTPPPVPPQPQP----------------------------PPAPAPQPVQSHPP 273
Query: 1154 PIPLLPPPKKRRKTVSFSAIEVVPAP----EPPPATPPQAK 1190
I P P K +K V A P PP+ PP+ K
Sbjct: 274 IIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPK 314
Score = 38.5 bits (88), Expect = 0.056
Identities = 81/393 (20%), Positives = 139/393 (35%), Gaps = 69/393 (17%)
Query: 1060 SSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPA 1119
S + +++ P P PPP++ P P PV + P + + P P Q P P
Sbjct: 965 SVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQ-PMQFSTHIQQPPPPQGQQPPHPP 1023
Query: 1120 GPTEESPPSAPLRPPEPPAGPPAPAPRPDERPS------SPIPLL--------------- 1158
P ++ PP P +P + +P + S +P PL+
Sbjct: 1024 -PGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQ 1082
Query: 1159 PPPK-----KRRKTVSFSAIEVVP----------------APEPPPATPPQAKFPGPASR 1197
PP+ K+++ + S ++ P P P P K P S
Sbjct: 1083 SPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKH--PESI 1140
Query: 1198 KAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVL- 1256
KAP + + P+D V PE+ A + + +E + + DL +
Sbjct: 1141 KAPVHLPQRPEMKPVDVGRPVIRPPEQ--NAPPPGAPDKDKQKQEPKTPVAPKKDLKIKN 1198
Query: 1257 --ADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPA 1314
+ +L P+ A S++ E A R + E AL + A
Sbjct: 1199 MGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKE-------EREKALKAQ----AEH 1247
Query: 1315 LRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEE-----EG 1369
+ + S ++ LE EA + QQ QQ++E+ +++ ++
Sbjct: 1248 AEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAA 1307
Query: 1370 EEEEEESSDSSSSSDGEGALRRRSLRSHARRRR 1402
+ +SS S D + L R+ R RRRR
Sbjct: 1308 ATPQAQSSQPQSMLDQQRELARK--REQERRRR 1338
Score = 37.7 bits (86), Expect = 0.096
Identities = 25/75 (33%), Positives = 28/75 (37%), Gaps = 22/75 (29%)
Query: 594 PPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRP-----------DGPP 642
P P TPP PP P PPP P P + S H P P+P D
Sbjct: 244 PQPLQTPPPVPPQPQPPPAPAPQPVQS-------HPPIIAATPQPVKTKKGVKRKADTTT 296
Query: 643 P----PEYPPPPPPP 653
P P + PP PP
Sbjct: 297 PTTIDPIHEPPSLPP 311
Score = 37.0 bits (84), Expect = 0.16
Identities = 29/100 (29%), Positives = 37/100 (37%), Gaps = 20/100 (20%)
Query: 1111 QEASPARPAGPT------EESPPSAPLRPPEPP---AGP-PAPAPRPDERPSSPIPLLPP 1160
+E A+P T +PP P PP A P P PA PD +P+ + P
Sbjct: 184 KETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVP 243
Query: 1161 PKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP 1200
P+ + P P PP PP A P P P
Sbjct: 244 PQPLQ----------TPPPVPPQPQPPPAPAPQPVQSHPP 273
Score = 33.5 bits (75), Expect = 1.8
Identities = 27/107 (25%), Positives = 39/107 (36%), Gaps = 13/107 (12%)
Query: 1119 AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPA 1178
A P + P+ P P P P P + P P + P V + VVP
Sbjct: 189 AKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDL----IVQTPVMTVVP- 243
Query: 1179 PEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEV 1225
P+P PP P P AP+ V+ H ++ + P+ V
Sbjct: 244 PQPLQTPPPVPPQPQPPPAPAPQPVQ--------SHPPIIAATPQPV 282
Score = 32.7 bits (73), Expect = 3.1
Identities = 14/43 (32%), Positives = 25/43 (58%)
Query: 455 EVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLK 497
+ + P+PA+ A + P PET+N + P Q + L + ++LK
Sbjct: 30 QAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLK 72
>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
Length = 1427
Score = 90.5 bits (223), Expect = 1e-17
Identities = 94/325 (28%), Positives = 130/325 (40%), Gaps = 38/325 (11%)
Query: 1037 SSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPV 1096
S+ +S +++ + +S ++ EE PAA A PPP E PT VP
Sbjct: 995 STPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAA---AVPPPEE---PTSPAAAVPT 1048
Query: 1097 PER-VAGSPVTPLPEQEASPARPAGPTEESP--PSAPLRPPEPPAGPPAPAPRPDERPSS 1153
PE + + P PE+ SPA A PT E P P+A + PE P P A P P+E P+S
Sbjct: 1049 PEEPTSPAAAVPTPEEPTSPAA-AVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEE-PTS 1106
Query: 1154 PIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA------TPPQAKFPGPASRKAPRGVERTI 1207
P +P P++ S VP PE P + TP + FP PA +
Sbjct: 1107 PAAAVPTPEEPA-----SPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAV 1161
Query: 1208 R-NLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARR 1266
P + AS + P S + T EE P V L
Sbjct: 1162 AVPTPEESASPAAAVPTP----AESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTS 1217
Query: 1267 GLPALPAVED--SEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAP 1324
++P E+ S A S+ E P + LE +PT A A+ PE + +P
Sbjct: 1218 PAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLE-------EPTSSAAAVLTPEELSSP 1270
Query: 1325 AALFSSPADEVLEAPEVVVAEAEEP 1349
AA S P E +P V+ EEP
Sbjct: 1271 AA--SVPTPEEPASPAAAVSNLEEP 1293
Score = 86.7 bits (213), Expect = 2e-16
Identities = 106/374 (28%), Positives = 142/374 (37%), Gaps = 47/374 (12%)
Query: 1062 SEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAG-SPVTPLPEQEASPARPAG 1120
+E++ E P + P E P A V V PE A + P PE+ SPA A
Sbjct: 965 TEEDGTPEGPVTPATTVHAPEE---PDTAAVRVSTPEEPASPAAAVPTPEEPTSPAA-AV 1020
Query: 1121 PTEESP--PSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPA 1178
PT E P P+A + PPE P P A P P+E P+SP +P P++ S VP
Sbjct: 1021 PTPEEPTSPAAAVPPPEEPTSPAAAVPTPEE-PTSPAAAVPTPEE-----PTSPAAAVPT 1074
Query: 1179 PEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGR 1238
PE P T P A P P +P T P A+ V + PEE + +
Sbjct: 1075 PEEP--TSPAAAVPTPEEPTSPAAAVPTPEE-PTSPAAAVPT-PEEPASPAAAVP----- 1125
Query: 1239 LTEEEEAEPGTEVDLAVLADLALTPARRGL--PALPAVEDSE----ATETSDEAERPRPL 1292
T EE A P V TP PA+P E+S A T +E+ P
Sbjct: 1126 -TPEEPASPAAAVP---------TPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAA 1175
Query: 1293 LSHILLEHNYALAV----KPTPPAPALRPPEPVPAPAALFSSPADEVLEAPE-----VVV 1343
+ ++A V +PT PA ++ P + A F+SPA V + E V
Sbjct: 1176 VPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAV 1235
Query: 1344 AEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRP 1403
+ EEP E EE SS ++S E + S+
Sbjct: 1236 SNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPAS 1295
Query: 1404 PPPPPPPPPRAYEP 1417
P P P A P
Sbjct: 1296 PAAAVPTPEVAAIP 1309
Score = 77.4 bits (189), Expect = 1e-13
Identities = 108/400 (27%), Positives = 143/400 (35%), Gaps = 61/400 (15%)
Query: 982 EEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSS 1041
EED E T E S S A + TS + + +
Sbjct: 966 EEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEE 1025
Query: 1042 SSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPER-V 1100
+S +++ +S ++ EE PAA A P P E PT VP PE
Sbjct: 1026 PTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAA---AVPTPEE---PTSPAAAVPTPEEPT 1079
Query: 1101 AGSPVTPLPEQEASPARPAGPTEESPPS------APLRPPEPPAGPPAP---------AP 1145
+ + P PE+ SPA A PT E P S P P P A P P P
Sbjct: 1080 SPAAAVPTPEEPTSPAA-AVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVP 1138
Query: 1146 RPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVER 1205
P+E P+ P P +P P++ SA V P P + P A P PA + V
Sbjct: 1139 TPEE-PAFPAPAVPTPEE-------SASAAVAVPTPEESASPAAAVPTPAESASFAAVVA 1190
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEV----DLAVLADLAL 1261
T+ P A+ V + V+ T EE P V + A LA
Sbjct: 1191 TLEE-PTSPAASVPTPAAMVA-------------TLEEFTSPAASVPTSEEPASLAAAVS 1236
Query: 1262 TPARRGLP--ALPAVED----SEATETSDEAERPRPLLSHILLEHNYALAV----KPTPP 1311
P P A+P +E+ + A T +E P + + A AV +P P
Sbjct: 1237 NPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASP 1296
Query: 1312 APALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKP 1351
A A+ PE PAA S P EV P V EE P
Sbjct: 1297 AAAVPTPEVAAIPAA--SVPTPEVPAIPAAAVPPMEEVSP 1334
Score = 59.3 bits (142), Expect = 3e-08
Identities = 51/179 (28%), Positives = 75/179 (41%), Gaps = 18/179 (10%)
Query: 1034 ESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAAL---------PSASPPPREV 1084
ES+S +++ + + S+S ++ ++ E + PAA+ P+AS P E
Sbjct: 1168 ESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEE 1227
Query: 1085 PVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPA 1144
P A V P + V L E +S A P E S P+A + PE PA P A
Sbjct: 1228 PASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAV 1287
Query: 1145 PRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGV 1203
+E P+SP +P P+ +AI P P P A P P +P GV
Sbjct: 1288 SNLEE-PASPAAAVPTPE-------VAAIPAASVPTPEVPAIPAAAVP-PMEEVSPIGV 1337
Score = 54.3 bits (129), Expect = 1e-06
Identities = 62/282 (21%), Positives = 105/282 (37%), Gaps = 17/282 (6%)
Query: 887 ALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGE-PGRPGTKPPKRD 945
A +P+ + + + E P + P E+ P E P P P +
Sbjct: 1056 AAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE 1115
Query: 946 EERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDD------EEDEEDEDREEAVDTTKK 999
E A+ + E AS ++ EE EE AV T ++
Sbjct: 1116 EPASPAA-------AVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEE 1168
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSE 1059
+ ++S+S ++ A + + + ++ ++ +S ++S +S
Sbjct: 1169 SASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEP 1228
Query: 1060 SSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPA 1119
+S P+A+ P E P + A V P E + + P PE+ ASPA
Sbjct: 1229 ASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTP-EELSSPAASVPTPEEPASPAAAV 1287
Query: 1120 GPTEE-SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPP 1160
EE + P+A + PE A P A P P E P+ P +PP
Sbjct: 1288 SNLEEPASPAAAVPTPEVAAIPAASVPTP-EVPAIPAAAVPP 1328
Score = 48.5 bits (114), Expect = 5e-05
Identities = 103/460 (22%), Positives = 163/460 (35%), Gaps = 49/460 (10%)
Query: 209 AATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSS 268
AA +A R + T + P GT AV + + + ++ Q+ S+ F+P+ +
Sbjct: 898 AAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVA-AAITQEGMSAVAGFSPEWA 956
Query: 269 Q---GTPYTSRGSTPYSQDSAYSSSTTSTSFKPR----RSENSYQDAFSRRHFSASSAST 321
P T TP + ++T +P R + A T
Sbjct: 957 ALAITVPITEEDGTP--EGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPT 1014
Query: 322 TASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTS 381
+ + A+ T+ ++A +S +++ + + S A P E TS
Sbjct: 1015 SPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEP-------TS 1067
Query: 382 YPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPG 441
T EEP A T E P+ + P P PT PA+ P PE P
Sbjct: 1068 PAAAVPTPEEPTSPAAAVPTPEE--PTSPAAAVPTPEEPTS-----PAAAVPTPEEP--- 1117
Query: 442 GGGGGGGPSPEREE-----VRTSPRPASPARSGSPAPETTNES---VPFAQHSSLDSRIE 493
P+PE V T PA PA + P PE + + VP + S+ +
Sbjct: 1118 ASPAAAVPTPEEPASPAAAVPTPEEPAFPAPA-VPTPEESASAAVAVPTPEESASPAAAV 1176
Query: 494 MLLKEQRSKFSFLASDTEEEEENSSMVLGAR--DTGSEVPSGSGHGPCTPPPAP-----A 546
E S + +A+ E +S+ A T E S + P + PA +
Sbjct: 1177 PTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVS 1236
Query: 547 NFEDVAPTGSGEPGATRESPKANGQNQASPCS-SGDDMEISDDDRGGSPPPAPTPPQQPP 605
N E+ PT T E P ++ +P S + + SP A + ++P
Sbjct: 1237 NPEE--PTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPA 1294
Query: 606 PPPPPPPPPPPYL---ASLPLGYPPHQPAYLLPPRPDGPP 642
P P P AS+P P PA +PP + P
Sbjct: 1295 SPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSP 1334
Score = 42.7 bits (99), Expect = 0.003
Identities = 32/119 (26%), Positives = 44/119 (36%), Gaps = 12/119 (10%)
Query: 545 PANFEDVAPTGSGEPGATRESPK---------ANGQNQASPCSSGDDMEISDDDRGGSPP 595
P ED P G P T +P+ + + ASP ++ E + +
Sbjct: 963 PITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPE--EPTSPAAAV 1020
Query: 596 PAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654
P P P P PPP P A++P P PA + P P+ P P P P P
Sbjct: 1021 PTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAV-PTPEEPTSPAAAVPTPEEP 1078
Score = 41.6 bits (96), Expect = 0.007
Identities = 70/345 (20%), Positives = 106/345 (30%), Gaps = 93/345 (26%)
Query: 315 SASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWN 374
+A++ S + A T + +A+ +++SS ++ + +++ + + + W
Sbjct: 897 TAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWA 956
Query: 375 RYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRP-----TDQDYRPPA 429
T E P P+ T + P EP T ++ PA
Sbjct: 957 ALAITVPITEEDGTPEGP------------VTPATTVHAPEEPDTAAVRVSTPEEPASPA 1004
Query: 430 SEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLD 489
+ P PE P P+PE P SPA + P E T+ +
Sbjct: 1005 AAVPTPEEPT---SPAAAVPTPEE--------PTSPAAAVPPPEEPTSPAA--------- 1044
Query: 490 SRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFE 549
A T EE + + A T E S P P P
Sbjct: 1045 -----------------AVPTPEEPTSPA---AAVPTPEEPTS-----PAAAVPTPEE-- 1077
Query: 550 DVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPP 609
PT T E P SP ++ P P P P P
Sbjct: 1078 ---PTSPAAAVPTPEEP-------TSPAAA---------------VPTPEEPTSPAAAVP 1112
Query: 610 PPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654
P P A++P P PA +P P P +P P P P
Sbjct: 1113 TPEEPASPAAAVPTPEEPASPAAAVPT----PEEPAFPAPAVPTP 1153
Score = 34.3 bits (77), Expect = 1.1
Identities = 60/272 (22%), Positives = 96/272 (35%), Gaps = 27/272 (9%)
Query: 189 TPQ--TVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQD 246
TP+ T P E+ AA T E +S AA P +P P ++
Sbjct: 1074 TPEEPTSPAAAVPTPEEPTSPAAAVPTPEE---PTSPAAAVPTPEEPA-SPAAAVPTPEE 1129
Query: 247 TSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGST---PYSQDSAYSSSTTSTSFKPRRSEN 303
+ ++ TP P + TP S + P ++SA ++ T P S +
Sbjct: 1130 PASPAAAVPTPEE--PAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPT---PAESAS 1184
Query: 304 SYQDAFSRRHFSASSASTTASTAIAATT------AATASSSASSSSLSSSSSSSSSSSSS 357
+ ++ +AS A+ AT AA+ +S +SL+++ S+ +S
Sbjct: 1185 FAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSP 1244
Query: 358 QFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLP--- 414
P + S P E P +P A + P S + +P
Sbjct: 1245 AAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPE 1304
Query: 415 ----PEPSRPTDQDYRPPASEAPPPEPPEPGG 442
P S PT + PA+ PP E P G
Sbjct: 1305 VAAIPAASVPTPEVPAIPAAAVPPMEEVSPIG 1336
Score = 32.0 bits (71), Expect = 5.3
Identities = 67/310 (21%), Positives = 105/310 (33%), Gaps = 49/310 (15%)
Query: 189 TPQ--TVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAG----TTAVGTPGNGTP 242
TP+ T P E+ AA T E +S AA P + A P P
Sbjct: 1022 TPEEPTSPAAAVPPPEEPTSPAAAVPTPEE---PTSPAAAVPTPEEPTSPAAAVPTPEEP 1078
Query: 243 CSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSE 302
S + + + T + TP+ P + + P ++ A ++ T +P
Sbjct: 1079 TSPAAAVPTPEEPTSPAAAVPTPEE----PTSPAAAVPTPEEPASPAAAVPTPEEPASP- 1133
Query: 303 NSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSS 362
A++ T A A T SAS++ + S+S +++
Sbjct: 1134 -------------AAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAA----- 1175
Query: 363 DANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTD 422
P ES S+ AT EEP + T + + P S PT
Sbjct: 1176 ---VPTPAES-------ASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTS 1225
Query: 423 QDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPA---PETTNES 479
++ PAS A PE P+ E E ++ +P SPA P +
Sbjct: 1226 EE---PASLAAAVSNPEEPTSPAAAVPTLE-EPTSSAAAVLTPEELSSPAASVPTPEEPA 1281
Query: 480 VPFAQHSSLD 489
P A S+L+
Sbjct: 1282 SPAAAVSNLE 1291
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 90.1 bits (222), Expect = 2e-17
Identities = 251/1253 (20%), Positives = 406/1253 (32%), Gaps = 222/1253 (17%)
Query: 212 ETAE-SRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQG 270
+T+E R+R + + AA A T V P + + S++ + + + T S G
Sbjct: 55 QTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 271 TPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSEN--SYQDAFSRRHFSASSASTTASTAIA 328
S ++ + T ++ P + + S R + SA+TT +
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 329 ATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRAT 388
+ A +A+ + S+ + SSS + S + + + +S +T
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV----ST 230
Query: 389 REEPP--GAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGG 446
+E P AP + P LPP ++ + E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 447 GGPSPEREEVRTSPRPA--SPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFS 504
S + +VR + PA +P + +PAP +V + +E S
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP-------EEDSESSS 343
Query: 505 FLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRE 564
+SD+EEE + +L A+ +G G+ P P + AP G+ G
Sbjct: 344 EESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR----KGAAPAPPGKTGPAVA 399
Query: 565 SPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLG 624
+A + + S SS E SD + + P P P AS P
Sbjct: 400 KAQAGKREEDSQSSS----EESDSEE-----------EAPAQAKPSGKAPQVRAASAPAK 444
Query: 625 YPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQT 684
P + A PPR GP + S + L A M
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA----------MNA 494
Query: 685 QMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYS 744
+ L + Q K GP G G PP + P A + +E + S
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGPV-----PPGKVGPATPSAQVGKWEEDSESSS 549
Query: 745 REAYHLP---MPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQE 801
E+ +P A P S+ P A+ K P A V
Sbjct: 550 EESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKA-------- 601
Query: 802 MKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLL 861
K ++N ES EE + + A + K LK P
Sbjct: 602 ----------EKPMDNS---------ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK 642
Query: 862 SLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEED 921
+ K TT A A + +R + P P+ S A RP+ +
Sbjct: 643 AC---PKKTNTT---ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSS 696
Query: 922 EDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEAS------------ 969
E+ +E++ G G + + +G K+ ++ +G
Sbjct: 697 EESDSEEEKTGLAVTVG-------QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP 749
Query: 970 --QESSSEKDEEDDEEDEEDEDREEA------VDTTKKETEVSDGEDEESDSSSKCSLYA 1021
+ +EK +ED E EE+ D EEA V T+ K+T+ S+K ++ A
Sbjct: 750 TVTQVKAEK-QEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 1022 DSDGENDSTSDSESSSSS----------------------------SSSSSSSSSSSSSS 1053
+ + S S ++++ + + S
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 1054 SSSSSESSSEDEEE---EERP--------AALPSASPPPREVPVPTPAPVEVPVPERV-- 1100
SS ES SE+E E + +P AAL A PR+ PTP P +
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928
Query: 1101 ---AGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPL 1157
+GS +PA PP + P PAGP A P + S+P
Sbjct: 929 QDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAA-TPAQAQAASTPRKA 987
Query: 1158 LPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASL 1217
R + S S E V PA++ G+ + +P H +
Sbjct: 988 RASESTARSSSSESEDEDVI----------------PATQCLTPGIRTNVVTMPTAHPRI 1031
Query: 1218 VKSWPEEVSRGGRSRAGGRGRLTEEEEAE-PGTEVDLAVLADLALTPARRGLPALPAVED 1276
+ S G S + R+++ ++ E P T+V A L LT A + A A E
Sbjct: 1032 AP----KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA 1087
Query: 1277 SEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVL 1336
PP +P V + + + +
Sbjct: 1088 Q--------------------------------PPVARTQPSSGVDSAVGTLPATSPQST 1115
Query: 1337 EAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSS--DGEG 1387
+ +PK ++QQ + E ++ E+SSDSSS S DGEG
Sbjct: 1116 SVQAKGTNKLRKPKLPEVQQATKA------PESSDDSEDSSDSSSGSEEDGEG 1162
Score = 74.3 bits (181), Expect = 9e-13
Identities = 128/624 (20%), Positives = 206/624 (33%), Gaps = 66/624 (10%)
Query: 829 SKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGAL 888
S+ + KP +++ + D E+ LL K+ A A S +GA
Sbjct: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 889 RLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPG--RPGTKPPKRDE 946
P K + EE S ++ +E+ P Q K +G+ R + P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 947 ERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDG 1006
+G RK+ G A+Q +++E+ EE + EA+ G
Sbjct: 448 RKGAAPAPPRKT------GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1007 EDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEE 1066
+ + +S + G ++ S+ S SSS SS+SS +
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP 561
Query: 1067 EEERPAALPSASPPPREVPVPTPA--PVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
PA S + P +PA P + P V P+ E+S EE
Sbjct: 562 TAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--------EE 613
Query: 1125 SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA 1184
S SA PA +P+ IP K+ T + + + V P
Sbjct: 614 SSDSADSEEA------PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667
Query: 1185 TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRG-----GRSRAGGRGRL 1239
A P +S G +R D +S +S EE G G++++ G+G
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAE----DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 723
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAV-----EDSEATETSDEAERPRPLLS 1294
+ + L P + G P + V EDSE++E ++E +
Sbjct: 724 VKAASVPVKGSLGQGTAPVL---PGKTG-PTVTQVKAEKQEDSESSEEESDSEEAAASPA 779
Query: 1295 HILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQ-- 1352
+ A A A + AP + ++ A +P V P+
Sbjct: 780 QVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTV 839
Query: 1353 -------------------QLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRS 1393
Q Q EE EEE + EEE + + G+ R +
Sbjct: 840 LARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA 899
Query: 1394 L---RSHARRRRPPPPPPPPPPRA 1414
L + R+ P PP P A
Sbjct: 900 LAPAKESPRKGAAPTPPGKTGPSA 923
Score = 64.7 bits (156), Expect = 7e-10
Identities = 127/579 (21%), Positives = 194/579 (33%), Gaps = 108/579 (18%)
Query: 897 RKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRP------------GTKPPKR 944
RK +E A + K+ R S P E E+E+ E + G P
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 945 DEERGKTQ----GKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE 1000
+E+ K + GK S + G+ + S + + E A T E
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS--------ANTTLVSE 172
Query: 1001 TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSES 1060
TE +G +++K + S G+ DS+S+ SSSS + S + +SS S
Sbjct: 173 TE-EEGSVPAFGAAAKPGMV--SAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVS 229
Query: 1061 SSEDEEEEERPA--------------ALPSA----------------SPPPREVPVPTPA 1090
+ E + PA ALP A S E P T +
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRS 289
Query: 1091 PV---EVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRP 1147
V E + R A +P P + A+PA P G PE + +
Sbjct: 290 QVKASEKILQVRAASAPAKGTPGKGATPA-PPGKAGAVASQTKAGKPEEDSESSSEESSD 348
Query: 1148 DERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP--PATPPQAKFPGPASRKAPRGVER 1205
E + L K KT A PA E P A P GPA KA G
Sbjct: 349 SEEETPAAKALLQAKASGKTSQVGAAS-APAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265
+ + + P + G++ +E G A P R
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA----------APAPPR 457
Query: 1266 RGLPALPAV----EDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPV 1321
+ PA V ++ ++ +S+E++ R L+ + A VKP +P ++P +
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-----NAAQVKPLGKSPQVKPASTM 512
Query: 1322 -PAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS 1380
P + P P A+ + EE+ E EESSD
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQV----------------GKWEEDSESSSEESSD-- 554
Query: 1381 SSSDGE-----GALRRRSLRSHARRRRPPPPPPPPPPRA 1414
SSDGE + +SL + + + P PP +A
Sbjct: 555 -SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Score = 63.2 bits (152), Expect = 2e-09
Identities = 224/1118 (20%), Positives = 345/1118 (30%), Gaps = 192/1118 (17%)
Query: 192 TVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSS 251
+VP G A +G A ++E SS +T G +V P S T S
Sbjct: 178 SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV--EGKPSV-KPAQVKASSVSTKESP 234
Query: 252 SRQDTPS--SFGQFTPQSSQGT-PYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDA 308
+R+ P+ G TPQ G P R P + + + S P + + + +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
Query: 309 FSRRHFSASSASTTASTAIAATTAATASSSASSSSL--------SSSSSSSSSSSSSQFR 360
A+SA + AT A + A +S S SSS SS S +
Sbjct: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
Query: 361 SSDANYPAYYESWNRYQRHTSYP----PRRATREEPPG----APFAENTAERFPPSYTSY 412
++ A A S P PR+ PPG A +R S +S
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS- 413
Query: 413 LPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPA 472
S +D + PA P + P+ SP + PR PA +
Sbjct: 414 -----SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV 468
Query: 473 PETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGS-EVP 531
+ +S ++ S DS E L ++ L + + S+M +G G+ VP
Sbjct: 469 GKQEEDSRSSSEES--DSDREALAAMNAAQVKPLGKSPQVKPA-STMGMGPLGKGAGPVP 525
Query: 532 SGSGHGPCTPPP----------------------------APA------NFEDVAPTGSG 557
G GP TP APA N PT S
Sbjct: 526 PGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 584
Query: 558 EPGATRES-PKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPP 616
G +++ P A P + + E S D PA Q P P
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK-- 642
Query: 617 YLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGM 676
+ P A + P R G P P V +
Sbjct: 643 ---ACPKKTNTTASAKVAPVRV-GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 677 PMSFQMQTQMLTRLHQLRQ-GKGL-IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYA 734
S + +T + + Q + GKGL + A++ P G+ G+ P P + P
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG----PTVTQV 754
Query: 735 QGQEGRGAYSREAYHLPMPMAAEPLP-SSSVSGEEARLPPREEAELAEGKTLPTAGTVGR 793
+ ++ + S E AA P +SV +A+ P + T+ G V
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 794 VLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEED---- 849
A Q S ++ + V + S K AA+ Q E+
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTV----LARGPASVPSVGKAVATAAQAQTGPEEDSGS 870
Query: 850 KEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEE 909
E+ E +L SG T I A L A P P + ++ +
Sbjct: 871 SEEESDSEEEAETLAQVKPSGKTHQIRA-----ALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 910 KRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEAS 969
+ + + +E D + E A KPP + ++ + A
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 970 QESSSEKDEEDDEEDEEDEDREEAVD------------------------------TTKK 999
+ +SE + EDED A ++K+
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 1000 ETEVSDGEDEE----------------------------SDSSSKCSLYADSDGENDSTS 1031
+ +SDG+ +E S++ + S G + +
Sbjct: 1046 SSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVG 1105
Query: 1032 DSESSSSSSSS------------------SSSSSSSSSSSSSSSSESSSEDEEEEERPAA 1073
++S S+S ++ + SS S SS+SSS EE+ E P
Sbjct: 1106 TLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQG 1165
Query: 1074 LPSASPPPREVPVPTPAPVEVPVPERVAGSP---------------VTPLPEQEASPARP 1118
SA PTP+ E V E A S +TP S A
Sbjct: 1166 AKSA-----HTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK 1220
Query: 1119 AGPTEESPP--SAPLRPPEPPAGPPAPAPRPDERPSSP 1154
A P +S P S+ L + P G P+ SP
Sbjct: 1221 ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1258
Score = 47.8 bits (112), Expect = 9e-05
Identities = 93/466 (19%), Positives = 160/466 (34%), Gaps = 69/466 (14%)
Query: 956 RKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSD---GEDEESD 1012
RK A + +A + S+ + +EE+E E T + + G D S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPA 1072
K + G+ ++ ++ + ++ S S S+ S++ + + EEE
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 1073 ALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLR 1132
A +A+ P + + + + + S T + E P+ + S S
Sbjct: 181 AFGAAAKPG----MVSAGQADSSSEDTSSSSDETDV---EGKPSVKPAQVKASSVSTKES 233
Query: 1133 PPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFP 1192
P A PAP D P LPP K+ +K P ++
Sbjct: 234 PARKAA--PAPGKVGDVTPQVKGGALPPAKRAKK---------------PEEESESSEEG 276
Query: 1193 GPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVD 1252
+ +AP G ++ E++ + + A +G T + A P
Sbjct: 277 SESEEEAPAGTRSQVKA------------SEKILQVRAASAPAKG--TPGKGATPAPPGK 322
Query: 1253 LAVLADLALTPARRGLPALPAVEDSEAT-ETSDEAERPRPLLSHILLEHNYALAVKPTPP 1311
+A + + G P EDSE++ E S ++E P +L + K +
Sbjct: 323 AGAVA----SQTKAGKPE----EDSESSSEESSDSEEETPAAKALL---QAKASGKTSQV 371
Query: 1312 APALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEE 1371
A P + P A +PA P V A+A + REE + EE +
Sbjct: 372 GAASAPAKESPRKGA---APAPPGKTGPAVAKAQAGK---------REEDSQSSSEESDS 419
Query: 1372 EEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEP 1417
EEE + + S G + S + P P PPR P
Sbjct: 420 EEEAPAQAKPS----GKAPQVRAASAPAKESPRKGAAPAPPRKTGP 461
Score = 40.0 bits (92), Expect = 0.019
Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 60/262 (22%)
Query: 753 PMAAEPLPSSSVSGEEAR--LPPREEAELAEGKTLPTAGTVG------------------ 792
P A + S G+EA P++ + +G P A T+
Sbjct: 1249 PQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNE 1308
Query: 793 -RVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKE 851
+V A +V+ + +++++ RK V + + + WES++ K Q AA+ K+
Sbjct: 1309 AQVQASVVKVLTELLEQE--RKKVVDTTKESSRKGWESRKRKLSGDQPAARTP---RSKK 1363
Query: 852 KTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKR 911
K KL A GG + + +G K KR + S +EK+
Sbjct: 1364 KKKLG----------AGEGGEASVSPEKTSTTSKG-------KAKR---DKASGDVKEKK 1403
Query: 912 PRPSTPAEEDEDDPEQE-------KEAGEPGRPGTKPP-------KRDEERGKTQGKHRK 957
+ S ++ +D+PE+E E G+ P +K K+D+E+ + + K +K
Sbjct: 1404 GKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKK 1463
Query: 958 SFALDSEGEEASQESSSEKDEE 979
+ DSE ++ +K E
Sbjct: 1464 ASTKDSESPSQKKKKKKKKTAE 1485
Score = 39.7 bits (91), Expect = 0.025
Identities = 94/465 (20%), Positives = 162/465 (34%), Gaps = 88/465 (18%)
Query: 970 QESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCS----------L 1019
Q++S + EED + ++ V +E S+ E+E ++K + L
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 1020 YAD--SDGENDSTSDSESSSSSSSSS-------------SSSSSSSSSSSSSSSESSSED 1064
AD S + + +++E + + +S S S S+ S+++ SE
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1065 EEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
EEE PA +A P + + + + + S T + E P+ +
Sbjct: 174 EEEGSVPAFGAAAKP-----GMVSAGQADSSSEDTSSSSDET---DVEGKPSVKPAQVKA 225
Query: 1125 SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA 1184
S S P A PAP D P LPP K+ +K P
Sbjct: 226 SSVSTKESPARKAA--PAPGKVGDVTPQVKGGALPPAKRAKK---------------PEE 268
Query: 1185 TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEE 1244
++ + +AP G ++ E++ + + A +G T +
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKA------------SEKILQVRAASAPAKG--TPGKG 314
Query: 1245 AEPGTEVDLAVLADLALTPARRGLPALPAVEDSE-ATETSDEAERPRPLLSHILLEHNYA 1303
A P +A + + G P EDSE ++E S ++E P +L
Sbjct: 315 ATPAPPGKAGAVA----SQTKAGKPE----EDSESSSEESSDSEEETPAAKALL---QAK 363
Query: 1304 LAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEE 1363
+ K + A P + P A +PA P V A+A +REE +
Sbjct: 364 ASGKTSQVGAASAPAKESPRKGA---APAPPGKTGPAVAKAQA---------GKREEDSQ 411
Query: 1364 EGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPP 1408
EE + EEE + + S + + R+ P PP
Sbjct: 412 SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456
Score = 36.6 bits (83), Expect = 0.21
Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 6/146 (4%)
Query: 1313 PALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPK----PQQLQQQREEGEEEGEEE 1368
P+++P + + + SPA + AP V + K P + ++ E E E EE
Sbjct: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
Query: 1369 GEEEEEESSDSSSSS--DGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTI 1426
G E EEE+ + S E L+ R+ + A+ P PP +A S+ +
Sbjct: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
Query: 1427 LYDIWNSGLDSEDMSYLRLTYERLLQ 1452
D +S +S D + LLQ
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQ 361
Score = 35.8 bits (81), Expect = 0.37
Identities = 97/472 (20%), Positives = 171/472 (36%), Gaps = 92/472 (19%)
Query: 190 PQTVPTGGKALSEKFQG-------SGAATETAESRRRSSSDTAAYPAGTT----AVGTPG 238
P +VP+ GKA++ Q SG++ E ++S + + P+G T A P
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 239 NGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKP 298
+P + P+ G+ P ++Q GS+ DS + TS +
Sbjct: 904 KESP---------RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQV 954
Query: 299 RRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQ 358
+ + D + AAT A ++S + +S S++ SSSS S+
Sbjct: 955 IKPPLIFVDP------------NRSPAGPAATPAQAQAASTPRKARASESTARSSSSESE 1002
Query: 359 ----FRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTA-------ERFPP 407
++ P N T++ PR A + GA ++ ++ + P
Sbjct: 1003 DEDVIPATQCLTPGI--RTNVVTMPTAH-PRIAPKASMAGASSSKESSRISDGKKQEGPA 1059
Query: 408 SYTSYLPPEPSRPTDQDYRPPASEAPPPEPP----EPGGG-----GGGGGPSPEREEVRT 458
+ S P T + A +A +PP +P G G SP+ V+
Sbjct: 1060 TQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQA 1119
Query: 459 S-----PRPASP-ARSGSPAPETTNESVPFAQHSS---------LDSRIEMLLKEQRSKF 503
+P P + + APE++++S + SS ++ L S+
Sbjct: 1120 KGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRT 1179
Query: 504 SFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFE--------DVAPTG 555
L +T E +V ++ S G TP PAN + D +P+
Sbjct: 1180 ETLVEETAAESSEDDVVAPSQSLLS--------GYMTPGLTPANSQASKATPKLDSSPSV 1231
Query: 556 SGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPP 607
S A ++ P +G+ +A P + + GG + T PQ+ P
Sbjct: 1232 SSTL-AAKDDP--DGKQEAKPQQAAG---MLSPKTGGKEAASGTTPQKSRKP 1277
Score = 32.0 bits (71), Expect = 5.3
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 17/162 (10%)
Query: 898 KEPSEISEASEEKRPRPSTPAEEDEDDPEQEK-EAGEPGRPGTKPPKRDEERGKTQGKHR 956
KE S S +++ PA +++K AGE G P K ++GK +
Sbjct: 1335 KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT---SKGKAK 1391
Query: 957 KSFALDSEGEEASQESSSEKDEEDDEEDEE-------DEDREEAVDTTKKETEVSDGEDE 1009
+ A E+ + S + +D E +EE E +++ +KKE + SD +
Sbjct: 1392 RDKASGDVKEKKGKGSLGSQGAKD-EPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1450
Query: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051
+ + K + ST DSES S ++ +
Sbjct: 1451 DKEKKEK-----KKKAKKASTKDSESPSQKKKKKKKKTAEQT 1487
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 89.0 bits (219), Expect = 4e-17
Identities = 75/305 (24%), Positives = 129/305 (42%), Gaps = 23/305 (7%)
Query: 876 EAFAFGSGLRGALRLPSFKVKRKEP----SEISEASEEKRPRPSTPAEEDEDDPEQEKEA 931
+++ GS R K EP S + E+S + P P ++ + D + E+
Sbjct: 143 DSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSES 202
Query: 932 GEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDRE 991
P R K K+ + R +++ K RK S ++ ++S +K + + R
Sbjct: 203 SSPRRERKKSSKKKKHRSESESKKRKH---RSPTPKSKRKSKDKKRKRSRSTTPAPKSRR 259
Query: 992 EAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTS-------DSESSSSSSSSSS 1044
T+ SD S S++ + G + S + D+ S ++S+
Sbjct: 260 AHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQ 319
Query: 1045 SSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSP 1104
SS +++ SS +D++++E+ A PS SP PAP + + ER GSP
Sbjct: 320 RPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPL-LAERHGGSP 378
Query: 1105 ----VTPLPEQEASPARPAGPT-EESPPSAPLRPPE---PPAGPPAPAPRPDERPSSPIP 1156
TPL ++ +P A PT + SPP +P + P+ + PP+P P R +S P
Sbjct: 379 QPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSP 438
Query: 1157 LLPPP 1161
P P
Sbjct: 439 ESPKP 443
Score = 83.6 bits (205), Expect = 2e-15
Identities = 81/264 (30%), Positives = 105/264 (39%), Gaps = 26/264 (9%)
Query: 912 PRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQE 971
P P P D +P A +P P + ER + S + S +S
Sbjct: 2497 PAPGVP-HSDVGEPPASTGAQQPSALAALQPAK--ERRSSSSSSSSSSSSSSSSSSSSSS 2553
Query: 972 SSSEKDEEDDEEDEEDEDREEAVDTTKKETE-----VSDGEDEESDSSSKCSLYADSDGE 1026
SSS D E E A+ T V +G E + +
Sbjct: 2554 SSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKR---------- 2603
Query: 1027 NDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPS-ASPPPREVP 1085
S SSSSSSSSSSSSSSSSSSSSSSSS SSS ++ PS A P P+ +P
Sbjct: 2604 ---KRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALP 2660
Query: 1086 VPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAP 1145
P +P + P ER + SP P+ S + P E PS P + +
Sbjct: 2661 KPA-SPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGS 2719
Query: 1146 RPDERPSSPIPLLPPPKKRRKTVS 1169
R +R S P K+RR+T S
Sbjct: 2720 RRGQRGDS---RSPSHKRRRETPS 2740
Score = 72.0 bits (175), Expect = 5e-12
Identities = 64/205 (31%), Positives = 92/205 (44%), Gaps = 28/205 (13%)
Query: 1023 SDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPR 1082
S + S+S S SSSSSS SSSSSSS SSSS SE SS + E +PS +P P+
Sbjct: 2532 SSSSSSSSSSSSSSSSSS----SSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPK 2587
Query: 1083 EV------PVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEP 1136
E P PTPA + + S + +S + + + S S+
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647
Query: 1137 PAGPPAPAPRPDERPSSPIPLLPPPKKRR--------------KTVSFSAIE-VVPAPEP 1181
P P P+ +P+S P PPP +RR +++S+S +E P+P+P
Sbjct: 2648 SPSPAKPGPQALPKPAS--PKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQP 2705
Query: 1182 PPATPPQAKFPGPASRKAPRGVERT 1206
P Q+ SR+ RG R+
Sbjct: 2706 SP-RDQQSSSSERGSRRGQRGDSRS 2729
Score = 68.6 bits (166), Expect = 5e-11
Identities = 81/303 (26%), Positives = 113/303 (37%), Gaps = 37/303 (12%)
Query: 191 QTVPTGGKALSEKFQGSGAATETAESRRRSS-----------SDTAAYPAGT-------T 232
QT P G S+ AT T+ + + SD PA T
Sbjct: 2465 QTTPVAG---SQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSAL 2521
Query: 233 AVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYS---S 289
A P S +S SSS + SS + S + + S P + A S
Sbjct: 2522 AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPS 2581
Query: 290 STTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSS 349
T + R R+ S+SS+S+++S++ ++++++++SSS+SSSS SSSSS
Sbjct: 2582 PTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2641
Query: 350 SSSSSSS-SQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPS 408
SSSSSSS S + P PP R P P R
Sbjct: 2642 SSSSSSSPSPAKPGPQALPK--------PASPKKPPPGERRSRSPRKPIDSLRDSR---- 2689
Query: 409 YTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARS 468
SY P E RP+ Q + G G PS +R SPRP S
Sbjct: 2690 SLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSS 2749
Query: 469 GSP 471
SP
Sbjct: 2750 RSP 2752
Score = 67.8 bits (164), Expect = 9e-11
Identities = 252/1267 (19%), Positives = 416/1267 (32%), Gaps = 164/1267 (12%)
Query: 217 RRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSR 276
RRRS S + A +G + TP SR TP+ G+ ++ SR
Sbjct: 632 RRRSRSRSPARRSGRSRSRTPARR---------GRSRSRTPARRGRSRSRTPARRSGRSR 682
Query: 277 GSTPYSQDSAYSSSTTSTSFKPR---RSENSYQDAFSRRHFSASSAST-TASTAIAATTA 332
TP + + S + + R R S+ RR S SS+ S +
Sbjct: 683 SRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSR 742
Query: 333 ATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEP 392
+ +S S +SS S S SS S+ +S + + S ++ + PPRR+
Sbjct: 743 SNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS--RSG 800
Query: 393 PGAPFAENTAERFPP--SYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPS 450
P A++ R PP S +S PP + + +S +P P+ G S
Sbjct: 801 SSQPKAKS---RTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITS 857
Query: 451 PEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDT 510
P+ E +P+ S S SP PE + + ++HS S + + S S +
Sbjct: 858 PQANEQSVTPQRRSCFES-SPDPELKSRTP--SRHSCSGSSPPRVKSSTPPRQSPSRSSS 914
Query: 511 EEEEENSSMVLGARD-TGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKAN 569
+ + + + R +GS PS S T P V+P + E +R P+ +
Sbjct: 915 PQPKVKAIISPRQRSHSGSSSPSPSR---VTSRTTPRRSRSVSPCSNVE---SRLLPRYS 968
Query: 570 GQNQASPCSSGDDMEISDDDRGGS----------PPPAPTPPQQPPPPPPPP-------- 611
+SP + GS PP P+ P P
Sbjct: 969 HSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQS 1028
Query: 612 -PPPPPYLASLPLGYPPHQPAY---LLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMD 667
P A + PP + + L + P++ P S L
Sbjct: 1029 CPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQS 1088
Query: 668 RLGAQ-WGGMPMSFQMQTQMLTRLHQLRQGKGLIAASA------GPPGGAFGEAFLPFPP 720
+ GG S T++ +R +RQ +G +AS P F +P
Sbjct: 1089 KSQTSPKGGRSRSSSPVTELASR-SPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPT 1147
Query: 721 P-----------QEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEA 769
+ A AL Q ++ P P+ P SS V +
Sbjct: 1148 VDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRP-ESSLVFKDTL 1206
Query: 770 RLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWES 829
R PPRE + G + T ++ ++ + +++E V E
Sbjct: 1207 RTPPRERS--GAGSSPETK-----------EQNSALPTSSQDEELMEVV---------EK 1244
Query: 830 KEEKAKPFQNAAKQQAKE------EDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSG 883
EE A + + KE E + + + L+L +E + S
Sbjct: 1245 SEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASS 1304
Query: 884 LRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPG---RPGTK 940
G P F + KE S S E P + + +G G G
Sbjct: 1305 WGG----PHFSPEHKELSN------------SPLRENSFGSPLEFRNSGPLGTEMNTGFS 1348
Query: 941 PPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE 1000
+++ G + +LD + + S + D ++ +++ + +
Sbjct: 1349 SEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLD 1408
Query: 1001 TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSES 1060
E S S+S + DG + S S SS S + S S S SS
Sbjct: 1409 AVPRTPSRERSSSASSPEM---KDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPG 1465
Query: 1061 SSEDEEEEERPAALPSASPPPREVPVPTPAP-VEVPVPERVAGSPVTPLPEQEASPAR-- 1117
+ R + +SP P+ +P TP P P + +TP E+ S +
Sbjct: 1466 MKDIPRTPSRGRSECDSSPEPKALP-QTPRPRSRSPSSPELNNKCLTPQRERSGSESSVD 1524
Query: 1118 -------PAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSF 1170
P G S S L P+ P D P S P ++R ++ S
Sbjct: 1525 QKTVARTPLGQRSRSGSSQEL--DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSS 1582
Query: 1171 SAIEVVPAPEPPPA---TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSR 1227
++ P + + P+ K A+ +A G + + P A ++ P
Sbjct: 1583 PEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSS----PEPKAPAPRALPRRSRS 1638
Query: 1228 GGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAE 1287
G S+ GRG E + + + ARRG + P + T +
Sbjct: 1639 GSSSK--GRG-----PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSS 1691
Query: 1288 RPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADE--------VLEAP 1339
R P L+ + + +P + PP +P+ PA++ +P
Sbjct: 1692 RSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSP 1751
Query: 1340 EVVV----AEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLR 1395
+ PKP+ LQ+ R E + S S+S + R RS
Sbjct: 1752 RTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ---RSRSRS 1808
Query: 1396 SHARRRR 1402
RRRR
Sbjct: 1809 RVTRRRR 1815
Score = 67.8 bits (164), Expect = 9e-11
Identities = 268/1277 (20%), Positives = 402/1277 (31%), Gaps = 185/1277 (14%)
Query: 207 SGAATETAESRRRSSSDTAAYPAGTTAV--GTPGNGTPCSQDTSFSSSRQDTPSSFGQFT 264
S + T R RS + + V G + TP + S SSS + S Q
Sbjct: 681 SRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRR 740
Query: 265 PQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS 324
+S+ S+P + S SS + + PR S RR S SS
Sbjct: 741 SRSN---------SSPEMKKSRISSRRSRSLSSPRSKAKSRLSL--RRSLSGSSPCPKQK 789
Query: 325 TAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTS-YP 383
+ + + SS + S + S SSSS + S + S + + + S P
Sbjct: 790 SQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTP 849
Query: 384 PRRATREEP------------------PGAPFAENTAERFPPSYTSYLPPEPSRPTDQDY 425
PR+ + P P T R S +S PP T
Sbjct: 850 PRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSS--PPRVKSSTPPRQ 907
Query: 426 RPPASEAPPPE-----PPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESV 480
P S +P P+ P G PSP R RT+PR +RS SP + +
Sbjct: 908 SPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPR---RSRSVSPCSNVESRLL 964
Query: 481 PFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCT 540
P HS S + E + S S + + + G +GS+ PC
Sbjct: 965 PRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSK-------SPCP 1017
Query: 541 PPPAPANFEDVAP------------TGSGEPGATRESPKANGQNQASPCSSGDDMEISDD 588
+ + P T GE S + GQ+Q SP D
Sbjct: 1018 QEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVR 1077
Query: 589 DRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRP---DGPPPPE 645
P + Q P P + L P Q P G P +
Sbjct: 1078 QSHSESPSLQSKSQTSPKGGRSRSSSP--VTELASRSPIRQDRGEFSASPMLKSGMSPEQ 1135
Query: 646 YPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAG 705
+ NSL RL M+ Q A+A
Sbjct: 1136 SRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQED----------------ATAS 1179
Query: 706 PPGGAFGEAFLPFPPPQEAAYGLPY--ALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSS 763
PP + F PFP L + L +E GA S P E +
Sbjct: 1180 PPRQK--DKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGS-------SPETKEQNSALP 1230
Query: 764 VSGEEARLPPREEAELAEGKTLPTAGTVGRVLAMLVQEMK--SIMQRDLNRKMVENVAFG 821
S ++ L E+ E P G++L+ L E+K S + + ++ E A
Sbjct: 1231 TSSQDEEL-----MEVVEKSEEP----AGQILSHLSSELKEMSTSNFESSPEVEERPAVS 1281
Query: 822 -AFDQWWESKEEKAKPFQNAAKQ------QAKEEDKEKTKLKEPGLLSLVDWAKSGGTTG 874
DQ +A + A + ++ + L+E S +++ SG
Sbjct: 1282 LTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGT 1341
Query: 875 IEAFAFGSGLRGALRLPSFKVKRKEPS-EISEASEEKRPRPSTPAEEDEDDPEQEKEAGE 933
F S ++ L P +PS ++ E S S+ E P+ ++AG
Sbjct: 1342 EMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTR-----SSGHSSSELSPDAVEKAGM 1396
Query: 934 PGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEA 993
P D +T + R S A E ++ + S + D
Sbjct: 1397 SSNQSISSPVLDAV-PRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRD---GSG 1452
Query: 994 VDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSS--SS 1051
+ + S G + + S+ DS E + + S S SS ++ +
Sbjct: 1453 TPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTP 1512
Query: 1052 SSSSSSSESSSEDEEEEERPAALPSASPPPREVPV-PTPAPVEVPVPERVAGSPV---TP 1107
S SESS + + P S S +E+ V P+ +P E + S TP
Sbjct: 1513 QRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTP 1572
Query: 1108 LPEQEASPARP-------AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPP 1160
L ++ S + P P S+P +P A P A + SSP P P
Sbjct: 1573 LRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQS----GSDSSPEPKAPA 1628
Query: 1161 PK--KRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERT------IRNLPL 1212
P+ RR S+ P+PE +T + P P SR A RG + R P
Sbjct: 1629 PRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP-PKSRTARRGSRSSPEPKTKSRTPPR 1687
Query: 1213 DHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALP 1272
+S +S PE +R R + + P T + TP R P
Sbjct: 1688 RRSS--RSSPE------LTRKARLSRRSRSASSSPETR---------SRTPPRH--RRSP 1728
Query: 1273 AVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPA 1332
+V E E S + R R A P + R P P P L S +
Sbjct: 1729 SVSSPEPAEKSRSSRRRRS-------------ASSPRTKTTSRRGRSPSPKPRGLQRSRS 1775
Query: 1333 DEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRR 1392
E Q ++R+ S S + R+
Sbjct: 1776 RSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA------RQE 1829
Query: 1393 SLRSHARRRRPPPPPPP 1409
S R+ +RRRR PP
Sbjct: 1830 SSRTSSRRRRGRSRTPP 1846
Score = 67.8 bits (164), Expect = 9e-11
Identities = 62/175 (35%), Positives = 73/175 (41%), Gaps = 30/175 (17%)
Query: 1035 SSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEV 1094
SSSSSSSSSSSSSSSSSSSSSSSS SSS D E P A + VP PTPAP E
Sbjct: 2533 SSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVAL---KRVPSPTPAPKEA 2589
Query: 1095 PVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSP 1154
V E G P P P + + + + S S+ + + + SS
Sbjct: 2590 -VRE---GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2645
Query: 1155 IPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRN 1209
+ P PA P P PAS K P ER R+
Sbjct: 2646 -----------------------SSSPSPAKPGPQALPKPASPKKPPPGERRSRS 2677
Score = 63.5 bits (153), Expect = 2e-09
Identities = 87/409 (21%), Positives = 138/409 (33%), Gaps = 56/409 (13%)
Query: 225 AAYPAGTTAVGTPGNGTPCSQDTSFSSSRQ-DTPSSFGQFTPQSSQGTPYTSRGSTPYSQ 283
A PA A+ G+GTP + SSSR P+S P+S+ T +
Sbjct: 2300 ARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVN-------- 2351
Query: 284 DSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSS 343
+ S T+ + P S R A S + S + + S S
Sbjct: 2352 ---IAGSRTAAALAPA-------SLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPL 2401
Query: 344 LSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENT-- 401
L + S + S+ SQ R + P+ + + PP + P + F++ +
Sbjct: 2402 LDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRC 2461
Query: 402 --AERFPPSYTSYLPPEPSRPTDQD-------YRPPASEAPPPEPPEPGGGGGGGGPSPE 452
A+ P + + L T PA P + EP G PS
Sbjct: 2462 LIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPS-- 2519
Query: 453 REEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512
+ +PA RS S + +++ S + SS S + +
Sbjct: 2520 ---ALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS---------------SGSSSS 2561
Query: 513 EEENSSMVLGARDTGSEVPSGSG------HGPCTPPPAPANFEDVAPTGSGEPGATRESP 566
+ E SS+ + VPS + P P PA + + + S ++ S
Sbjct: 2562 DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSS 2621
Query: 567 KANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPP 615
++ + +S SS S SP PA PQ P P P PPP
Sbjct: 2622 SSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670
Score = 55.5 bits (132), Expect = 4e-07
Identities = 78/299 (26%), Positives = 114/299 (38%), Gaps = 30/299 (10%)
Query: 213 TAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTP 272
+A S+ R +S+ A P+ + P +QD R PS+F QS
Sbjct: 2412 SAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQD----QPRSPVPSAFSD---QSRCLIA 2464
Query: 273 YTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS--TAIAAT 330
T+ + S S ++TTS++ + AST A +A+AA
Sbjct: 2465 QTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL 2524
Query: 331 TAA-----TASSSASSSSLSSSSSSSSSSSSSQFRSSDA---NYPAYYESWNRYQRHTSY 382
A ++SSS+SSSS SSSSSSSSSSSSS SSD+ + P E + +
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTP 2584
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGG 442
P+ A RE P P R S +S S + +S +
Sbjct: 2585 APKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSS---------- 2634
Query: 443 GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRS 501
S +SP PA P P P + + P + S + L++ RS
Sbjct: 2635 ---SSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRS 2690
Score = 54.3 bits (129), Expect = 1e-06
Identities = 74/323 (22%), Positives = 118/323 (36%), Gaps = 46/323 (14%)
Query: 178 KYYELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTP 237
K Y L+ S + P K +K +G + + + R+ SS + + + +
Sbjct: 169 KPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRK 228
Query: 238 GNG-TPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSF 296
TP S+ S R+ + S+ TP P + R S DSA SS T+
Sbjct: 229 HRSPTPKSKRKSKDKKRKRSRST----TP-----APKSRRAHRSTSADSASSSDTS---- 275
Query: 297 KPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSS 356
R S S+A+ T +TA+A + + AS S ++S+
Sbjct: 276 ---------------RSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQR 320
Query: 357 SQFRSSDANYPAY-YESWNRYQRHTSY------PPRRATREEPPGAP--FAENTAERFPP 407
+ P+ YE ++ ++ S P R +T EPP AE P
Sbjct: 321 PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQP 380
Query: 408 SYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPAR 467
T+ L EP P + P + PP+ PE SP SP+P +R
Sbjct: 381 LATTPLSQEPVNPPSE--ASPTRDRSPPKSPEKLPQSSSSESSPP------SPQPTKVSR 432
Query: 468 SGSPAPETTNESVPFAQHSSLDS 490
S +PE+ + H + S
Sbjct: 433 HASSSPESPKPAPAPGSHREISS 455
Score = 53.5 bits (127), Expect = 2e-06
Identities = 103/450 (22%), Positives = 147/450 (32%), Gaps = 47/450 (10%)
Query: 224 TAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDT--PSSFGQFTPQSSQGTPYTSRGSTPY 281
+A PA TAV + TP + +S + PS+ P++ G+
Sbjct: 2244 SARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTP 2303
Query: 282 SQDSAYS---SSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSS 338
+ +A S S T T+ S + Q S SA TA IA + A A +
Sbjct: 2304 AALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAP 2363
Query: 339 ASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPR-RATREEPPGAPF 397
AS +S + + S ++ +S A + R TS P RA PP AP
Sbjct: 2364 ASLTSARMAPALSGANLTSPRVPLSA--------YERVSGRTSPPLLDRARSRTPPSAPS 2415
Query: 398 AENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGG----------GG 447
PS +S + PS Q PPA + P P G
Sbjct: 2416 QSRMTSERAPSPSSRMGQAPS----QSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAG 2471
Query: 448 GPSPEREEVRTSPRPASPARS--GSPAPETTNESV---PFAQHSSLDSRIEML--LKEQR 500
S V T+ A PAP + V P + + S + L KE+R
Sbjct: 2472 SQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERR 2531
Query: 501 SKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPC--------TPPPAPANFEDVA 552
S S +S + +SS + S S P P P PA E V
Sbjct: 2532 SSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVR 2591
Query: 553 PTGSGEPGAT----RESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPP 608
EP R S ++ + +S SS S S + + P P
Sbjct: 2592 EGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSP 2651
Query: 609 PPPPPPPPYLASLPLGYPPHQPAYLLPPRP 638
P P + P PP + P +P
Sbjct: 2652 AKPGPQALPKPASPKKPPPGERRSRSPRKP 2681
Score = 50.8 bits (120), Expect = 1e-05
Identities = 98/448 (21%), Positives = 147/448 (32%), Gaps = 85/448 (18%)
Query: 1033 SESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAP- 1091
S S + + +S++ S+ +++ + PA+L SA P +P
Sbjct: 2325 SSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPR 2384
Query: 1092 VEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERP 1151
V + ERV+G PL ++ S +PPSAP + P+P+ R + P
Sbjct: 2385 VPLSAYERVSGRTSPPLLDRARS---------RTPPSAPSQSRMTSERAPSPSSRMGQAP 2435
Query: 1152 SSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKF------PGPASRKAPRGVER 1205
S LLPP + + P P A Q++ P S+ G
Sbjct: 2436 SQS--LLPPAQDQ------------PRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVA 2481
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265
T + DH ++ V E A G + A LA L R
Sbjct: 2482 TTTSSAGDHNGMLSVPAPGVPHSD----------VGEPPASTGAQQPSA-LAALQPAKER 2530
Query: 1266 RGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPAL-RPPEPVPAP 1324
R + + S ++ +S + S E + P P AL R P P PAP
Sbjct: 2531 RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSL----PVQPEVALKRVPSPTPAP 2586
Query: 1325 AALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSD 1384
+ V E P+P +++R SS SSSSS
Sbjct: 2587 ---------------KEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSS 2631
Query: 1385 GEGALRRRSLRSHARRRRPPPPPPP-----------PPP---RAYEPRSEFEQMTILYDI 1430
+ S S + P P P PPP R+ PR + +
Sbjct: 2632 SSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLR----- 2686
Query: 1431 WNSGLDSEDMSYLRLTYERLLQQTSGAD 1458
DS +SY + R Q S D
Sbjct: 2687 -----DSRSLSYSPVERRRPSPQPSPRD 2709
Score = 50.4 bits (119), Expect = 1e-05
Identities = 59/278 (21%), Positives = 95/278 (34%), Gaps = 47/278 (16%)
Query: 422 DQDYRPPASEAPPPEPPEPGG----GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTN 477
D R ++ P PEPP+P P+P++++ + + S SP E
Sbjct: 152 DPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKK 211
Query: 478 ES-------------------VPFAQHSSLD---SRIEMLLKEQRSKFSFLASDTEEEEE 515
S P ++ S D R +S+ + ++ +
Sbjct: 212 SSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASS 271
Query: 516 NSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQAS 575
+ + +R ++ + + G P + E AP EPG T ++ +
Sbjct: 272 SDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAP--FSEPGTTSTQRPSSPETATK 329
Query: 576 PCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPP---------PPYLASLPLGYP 626
SS + + D + P+P+P + P PP P P P LA+ PL
Sbjct: 330 QPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQE 389
Query: 627 PHQPAYLLPPRPDGPPP--PEYPP--------PPPPPP 654
P P P D PP PE P PP P P
Sbjct: 390 PVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQP 427
Score = 47.8 bits (112), Expect = 9e-05
Identities = 104/491 (21%), Positives = 173/491 (35%), Gaps = 85/491 (17%)
Query: 935 GRPGTKPP-KRDEERGKTQG---KHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDR 990
GR G +P K +EE + + K LD E + + E +E +E+ E++
Sbjct: 28 GRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQI 87
Query: 991 EEAVDTTKK---ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSS 1047
+E V T + E +V+ G EE+ G+ + +++ + + +
Sbjct: 88 QEKVATFRLMLLEKDVNPGGKEETP------------GQRPAVTETHQLAELNEKKNERL 135
Query: 1048 SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107
++ S S + SS D + R A P+ PP V R + S +P
Sbjct: 136 RAAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLV------------RESSSSRSP 183
Query: 1108 LPEQEASPARP-AGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRK 1166
P+Q+ + G ES S+P R E R + P PK +RK
Sbjct: 184 TPKQKKKKKKKDRGRRSES--SSPRR--ERKKSSKKKKHRSESESKKRKHRSPTPKSKRK 239
Query: 1167 TVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEV- 1225
+ + ++ P P SR+A R + S +S +
Sbjct: 240 S------------KDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTH 287
Query: 1226 --SRGGRSRAGGRGRLTEEEE--AEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATE 1281
+ GRS + GR E + +EPGT + R P + S E
Sbjct: 288 TTALAGRSPSPASGRRGEGDAPFSEPGTT-----------STQRPSSPETATKQPSSPYE 336
Query: 1282 TSDEAERPRPLLSHILLEHNYALAVKPTP-PAPALRPPEPVPAPAALFSSPADEVLEAPE 1340
D+ ++ + A +P+P P + PEP PAP L A+ +P+
Sbjct: 337 DKDKDKKEKS-------------ATRPSPSPERSSTGPEP-PAPTPLL---AERHGGSPQ 379
Query: 1341 VVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARR 1400
+ A P Q+ E + + E+ SSSS + + + HA
Sbjct: 380 PL---ATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASS 436
Query: 1401 RRPPPPPPPPP 1411
P P P P
Sbjct: 437 SPESPKPAPAP 447
Score = 46.2 bits (108), Expect = 3e-04
Identities = 57/252 (22%), Positives = 90/252 (35%), Gaps = 22/252 (8%)
Query: 415 PEPSRPTDQDYRPPASEAPPPEPPEP----GGGGGGGGPSPEREEVRTSPRPASPARSGS 470
PEP +P +S +P P+ + G SP RE ++S + RS S
Sbjct: 165 PEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKH--RSES 222
Query: 471 PAPETTNES-VPFAQHSSLDS---RIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDT 526
+ + + S P ++ S D R +S+ + ++ + + + +R
Sbjct: 223 ESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSA 282
Query: 527 GSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATR----ESPKANGQNQASPCSSGDD 582
++ + + G P + E AP EPG T SP+ + +SP
Sbjct: 283 AAKTHTTALAGRSPSPASGRRGEGDAPFS--EPGTTSTQRPSSPETATKQPSSP------ 334
Query: 583 MEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPP 642
E D D+ P+P + P PP P P LA G P L P PP
Sbjct: 335 YEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPP 394
Query: 643 PPEYPPPPPPPP 654
P PP
Sbjct: 395 SEASPTRDRSPP 406
Score = 46.2 bits (108), Expect = 3e-04
Identities = 56/250 (22%), Positives = 90/250 (36%), Gaps = 25/250 (10%)
Query: 255 DTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSEN-----SYQDAF 309
+ P + SS +P + +D S ++S + ++S S ++
Sbjct: 166 EPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK 225
Query: 310 SRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAY 369
R+H S + S S + + + + S S+S+ S+SSS RS + A
Sbjct: 226 KRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAK 285
Query: 370 YESWNRYQRHTSYPP-RRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPP 428
+ R S RR + P P +T P + P P D+D +
Sbjct: 286 THTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEK 345
Query: 429 ASEAPPPEP------PEP-----------GGGGGGGGPSPEREEVRTSPRPASPARSGSP 471
++ P P P PEP GG +P +E P ASP R SP
Sbjct: 346 SATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSP 405
Query: 472 --APETTNES 479
+PE +S
Sbjct: 406 PKSPEKLPQS 415
Score = 45.8 bits (107), Expect = 4e-04
Identities = 78/308 (25%), Positives = 113/308 (36%), Gaps = 48/308 (15%)
Query: 200 LSEKFQGSGAATET-----AESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQ 254
LS + SG++ E A R +S SD++ P P + S SSS+
Sbjct: 1591 LSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALP------RRSRSGSSSKG 1644
Query: 255 DTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQ----DAFS 310
PS G + +SS P SR + S+ S + + T + R S +S + S
Sbjct: 1645 RGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLS 1704
Query: 311 RRHFSASSASTTAS-------TAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSD 363
RR SASS+ T S + + ++ A S SS S+SS + ++S + RS
Sbjct: 1705 RRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPS 1764
Query: 364 ANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYT-------SYLPPE 416
S +R +R + RR R + R T Y
Sbjct: 1765 PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRS 1824
Query: 417 PSRP----TDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARS-GSP 471
P+R T R S PP S +R RTSP P +RS SP
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPP--------------TSRKRSRSRTSPAPWKRSRSRASP 1870
Query: 472 APETTNES 479
A + S
Sbjct: 1871 ATHRRSRS 1878
Score = 43.9 bits (102), Expect = 0.001
Identities = 98/443 (22%), Positives = 148/443 (33%), Gaps = 62/443 (13%)
Query: 252 SRQDTPSSFGQFTPQSSQGTPYTS-----RGSTPYSQDSAYSSSTTSTSFKPRRSENSYQ 306
SR TP+ G +S Q S R +P + + S S + R ++ +
Sbjct: 495 SRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWS-RSRNTQRRGR 553
Query: 307 DAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANY 366
+RR S S + T + + T A S + + + S S + + S+ R+
Sbjct: 554 SRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRG 613
Query: 367 PAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYR 426
+ + R + T P RR +R P A + + R P P+R R
Sbjct: 614 RSRSRTPARRRSRTRSPVRRRSRSRSP-ARRSGRSRSRTPARRGRSRSRTPARRGRSRSR 672
Query: 427 PPASEAPPPEPPEPGGGGGGGGPSPEREEVRT----------SPRPASPARSGSPAPETT 476
PA + P G +P R R+ S P RSGS + E
Sbjct: 673 TPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSS-ERK 731
Query: 477 NESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGH 536
N+S + S +S EM ++S+ S + SS A+ S S SG
Sbjct: 732 NKSRTSQRRSRSNSSPEM----KKSRIS-----SRRSRSLSSPRSKAKSRLSLRRSLSGS 782
Query: 537 GPC------TPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDDR 590
PC TPP + +GS +P A +P ++ +SP S
Sbjct: 783 SPCPKQKSQTPPRR-------SRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSH 835
Query: 591 GGSPP----PAPTPPQQPPPPPP---------------PPPPPPPYLASLPLGYPPHQPA 631
S P + TPP+Q P P P + P H +
Sbjct: 836 SSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTP---SRHSCS 892
Query: 632 YLLPPRPDGPPPPEYPPPPPPPP 654
PPR PP P P
Sbjct: 893 GSSPPRVKSSTPPRQSPSRSSSP 915
Score = 43.5 bits (101), Expect = 0.002
Identities = 77/318 (24%), Positives = 110/318 (34%), Gaps = 50/318 (15%)
Query: 376 YQRHTSYPPRRATRE--EPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDY-RPPASEA 432
Y +S+ P+R RE +P P + R S S P + + +D R S +
Sbjct: 145 YVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSS 204
Query: 433 PPPEPPEPGGGGGGGGPSPEREEVRTSPRPASP----------ARSGSPAPETTNESVPF 482
P E + S ++ SP P S +RS +PAP++
Sbjct: 205 PRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAH--- 261
Query: 483 AQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENS-SMVLGARDTG----SEVPSGSGHG 537
+ +S DS RS+ + + T S S G R G SE + S
Sbjct: 262 -RSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQR 320
Query: 538 PCTPPPA---PANFEDVAPTGSGEPGATRESPK----ANGQNQASPCSSGDDMEISDDDR 590
P +P A P++ + E ATR SP + G +P + +
Sbjct: 321 PSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTP------LLAERH 374
Query: 591 GGSPPPAPTPPQQPPPPPPP----------PPPPP---PYLASLPLGYPPHQPAYLLPPR 637
GGSP P T P P PP PP P P +S P QP +
Sbjct: 375 GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHA 434
Query: 638 PDGPPPPEYPPPPPPPPH 655
P P+ P P P H
Sbjct: 435 SSSPESPK--PAPAPGSH 450
Score = 39.7 bits (91), Expect = 0.025
Identities = 60/283 (21%), Positives = 88/283 (31%), Gaps = 53/283 (18%)
Query: 350 SSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSY 409
S SSS + + S ES ++ ++H S P+ + + + +T P S
Sbjct: 200 SESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPA-PKSR 258
Query: 410 TSYLPPEPSRPTDQDYRPPASEAPPPEP---------PEPGGGGGGGGPSPEREEVRTSP 460
++ + D S + + P P G G G +P E P
Sbjct: 259 RAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSE-----P 313
Query: 461 RPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMV 520
S R SP T S P+ K+++ K + S + E
Sbjct: 314 GTTSTQRPSSPETATKQPSSPYEDKD----------KDKKEKSATRPSPSPERSS----- 358
Query: 521 LGARDTGSEVPS-----GSGHGPCTPPPA--PANFEDVAPTGSGEPGATRESPKANGQNQ 573
TG E P+ HG P A P + E V P P R PK
Sbjct: 359 -----TGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPK------ 407
Query: 574 ASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPP 616
S + + S P P PT + P P P P
Sbjct: 408 -----SPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAP 445
Score = 35.8 bits (81), Expect = 0.37
Identities = 83/361 (22%), Positives = 113/361 (31%), Gaps = 58/361 (16%)
Query: 1071 PAALPSASPPPREVPVPTPAPVEVPVPERV-----AGSPVTPL--PEQEASPARPAGPTE 1123
P+A+ A P P A P +G+P T P +P PA
Sbjct: 2279 PSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANL 2338
Query: 1124 ESPPSAPLRPPEPPAGP-PAPAPRPDERPSSPI-PLLPPPKKRRKTVSFSAIEVVPAPEP 1181
P SA P AG A A P S+ + P L V SA E V
Sbjct: 2339 VGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTS 2398
Query: 1182 PPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTE 1241
PP R RT + P + P SR G++ + L
Sbjct: 2399 PPLLD--------------RARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQS---LLP 2441
Query: 1242 EEEAEPGTEVDLAVLAD----LALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHIL 1297
+ +P + V A +A T G +L + + AT TS +
Sbjct: 2442 PAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSS--GAVATTTSSAGD---------- 2489
Query: 1298 LEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQ 1357
HN L+V P P P EP PA + P + A + K ++
Sbjct: 2490 --HNGMLSV-PAPGVPHSDVGEP----------PASTGAQQPSALAA-LQPAKERRSSSS 2535
Query: 1358 REEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEP 1417
SS SSSSD EG+ ++ +R P P P P E
Sbjct: 2536 SSSSSSSSSSSSSSSSSSSSSGSSSSDSEGS--SLPVQPEVALKRVPSPTPAPKEAVREG 2593
Query: 1418 R 1418
R
Sbjct: 2594 R 2594
Score = 33.1 bits (74), Expect = 2.4
Identities = 93/429 (21%), Positives = 134/429 (31%), Gaps = 48/429 (11%)
Query: 216 SRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTS 275
SRRRS S T + TP T+ SR TP + + S+ P T
Sbjct: 1919 SRRRSRSRTPPVTRRRSRSRTP---------TTRRRSRSRTPPVTRRRS--RSRTPPVTR 1967
Query: 276 RGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATA 335
R S + S + TS RR S +RR + ++ T + + T A
Sbjct: 1968 RRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIR 2027
Query: 336 SSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRAT------R 389
S S + L S S S + R S + P R RR+ R
Sbjct: 2028 RRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDR 2087
Query: 390 EEPPGAPFAEN-TAERFPP-----SYTSYLPPEPSRPTDQD-------YRPPASEAPPPE 436
P N + R PP S S PT D P S P
Sbjct: 2088 SRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMS 2147
Query: 437 PPEPGGGGGGGGPSPEREEVRTSPRPASPARS-----------GSPAPETTNESVPFAQH 485
+ GG GP P + + + P + A+S G+ P + + A
Sbjct: 2148 VLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAAR 2207
Query: 486 SSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAP 545
S L+ + + + LAS + + AR +P+ P A
Sbjct: 2208 MSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPA--IPTAVNLADSRTPAAA 2265
Query: 546 ANFEDVAPTGSGEPGATR----ESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPP 601
A +P + P A +P A N A + +S G+PP A P
Sbjct: 2266 AAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTG-SGTPPTAANYP 2324
Query: 602 QQPPPPPPP 610
P P
Sbjct: 2325 SSSRTPQAP 2333
>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
Length = 1094
Score = 87.8 bits (216), Expect = 8e-17
Identities = 143/620 (23%), Positives = 208/620 (33%), Gaps = 117/620 (18%)
Query: 248 SFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQD 307
S S+ + S G+F+ SS R P S +S S +S + S S
Sbjct: 381 SLHSASPASVRSLGRFSSVSSP----QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLS--- 433
Query: 308 AFSRRHFSASSASTTASTAIAAT--------TAATASSSASSSSLSSSSSSSSSSSSSQF 359
S+ S+TAS ++ + + S++ +S +LS SS S S
Sbjct: 434 --SKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSL 491
Query: 360 RSSDANYPAYYESWNRYQRHTSYP------PRRATREEPPGAPFAENTAERFPPSYTSYL 413
R P + + +QR + P P + R++ P P T + +
Sbjct: 492 RKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGS-EGAGAAPC 550
Query: 414 PPEPSRPTDQDYRPPASEAPPPEPPE---PGGGGGGGGPSPEREEVRTSPRPASPARSGS 470
PP P+ P S PP P P G +P + PASP ++
Sbjct: 551 PPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQP 610
Query: 471 PAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEV 530
P PE +SL S + S S + + ++ D
Sbjct: 611 PKPERV---------TSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIP 661
Query: 531 PSGSGHGPCTPPPA-PANFEDVAPTGS------GEPGATRESPKANGQNQASPCSSGDDM 583
P P +PPP+ P + AP + G T SP++ Q + +
Sbjct: 662 PHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESP 721
Query: 584 EISDDDRGGSPPPAPTPPQQPPPPP--------------------------PPPPPPPPY 617
IS D SPPP+P P PPPPP PPPPPP P
Sbjct: 722 VISKDQ---SPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPE 778
Query: 618 LASLPLG-YPPHQPAY--LLPPRPDGP----------------------PPPEYPPPPPP 652
L + +PP + A+ + P P GP PP P PPP
Sbjct: 779 EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
Query: 653 PP------HIYDFVNSLELMDRLGAQWGGMP----MSFQMQTQMLTRLHQLRQGKGLIAA 702
PP V L + +G GG P + + T L ++ +LR
Sbjct: 839 PPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLR-------- 890
Query: 703 SAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSS 762
S G PGGA A P P + L G ++ A+E L S+
Sbjct: 891 SVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSA 950
Query: 763 SVSG--EEARLPPREEAELA 780
+G E PP+ A A
Sbjct: 951 QPNGPPEAEPRPPQSPASTA 970
Score = 62.0 bits (149), Expect = 5e-09
Identities = 109/443 (24%), Positives = 157/443 (35%), Gaps = 42/443 (9%)
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSES-----SSSSSSSSSSSSSSSSSSS 1054
+T VSDG S SSK S+G+ +S++ S S S S S S++ +S
Sbjct: 423 DTIVSDG----STLSSK----GGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASD 474
Query: 1055 SSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEAS 1114
+ S SS + L PPPR + + VP+ G P P PE++
Sbjct: 475 TLSIRSSGQLSGRSVSLRKLKRPPPPPRRTH--SLHQRGLAVPDGPLGLP--PKPERKQQ 530
Query: 1115 PARPAGPT---EESPPSAPLRPPEPPAGPPAPAPRPDERPS-SPIPLLPPPKKRRKTVSF 1170
P P PT E +AP P + P +P RP SP L P +
Sbjct: 531 PQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSS------GY 584
Query: 1171 SAIEVVPAPEP-----PPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEV 1225
S+ P P PPA+P +A+ P P + R ++ + L S P
Sbjct: 585 SSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSS-SLTSLCSSSSDPAPS 643
Query: 1226 SRGGRSRAGGRG-RLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSD 1284
R G G R + + PA L A V +T +
Sbjct: 644 DRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDAS 703
Query: 1285 EAERPRPLLSHILLEHNYALAVK----PTPPAPALRPPEPVPAPAALFSSP-ADEVLEAP 1339
P P + L+ + ++ P+PP PP P P + +P A E E P
Sbjct: 704 PQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEP 763
Query: 1340 EVVVAEAEEPKPQQLQQQREEGEEEGEEEG--EEEEEESSDSSSSSDGEGALRRRSLRSH 1397
P P +Q + EE E + S S + + S +
Sbjct: 764 LQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSAT 823
Query: 1398 ARRRRPP-PPPPPPPPRAYEPRS 1419
A + +PP P PPP P A P S
Sbjct: 824 ALQIQPPGSPDPPPAPPAPAPAS 846
Score = 58.2 bits (139), Expect = 7e-08
Identities = 111/465 (23%), Positives = 159/465 (34%), Gaps = 130/465 (27%)
Query: 1034 ESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEE-------------RPAALPSASPP 1080
E +S S +S SSS +S SSSS+ + D + P SPP
Sbjct: 614 ERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPP 673
Query: 1081 PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPT--------------EESP 1126
P + P PA + P V G P+ +ASP P P ++SP
Sbjct: 674 PSKPRSPNPAAPALAAPAVVPG----PVSTTDASPQSPPTPQTTLTPLQESPVISKDQSP 729
Query: 1127 PSAP---LRPPEPPAG------------------------PPAPAPRPDERPSSPIPLLP 1159
P +P PP PP PP P P P+E+ S P
Sbjct: 730 PPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADF-P 788
Query: 1160 PPKKRRKTV-----------------------SFSAIEVVP--APEPPPATPPQAKFPGP 1194
PP++ +V S +A+++ P +P+PPPA P P P
Sbjct: 789 PPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPA----PAP 844
Query: 1195 ASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLA 1254
AS AP V + + P+ G S+ GG R E+ P L
Sbjct: 845 AS-SAPGHVAKLPQKEPV----------------GCSKGGGPPR---EDVGAPLVTPSLL 884
Query: 1255 VLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTP-PAP 1313
+ L A G P PA+ S +PL AL+ + +P PAP
Sbjct: 885 QMVRLRSVGAPGGAPT-PALGPSAP---------QKPL--------RRALSGRASPVPAP 926
Query: 1314 ALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEG-EEEGEEEGEEE 1372
+ V A S A E L + + EP+P Q +G + + E
Sbjct: 927 SSGLHAAVRLKAC--SLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLE 984
Query: 1373 EEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEP 1417
S ++ + RS+ + P P PPP A +P
Sbjct: 985 RPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKP 1029
Score = 57.8 bits (138), Expect = 9e-08
Identities = 120/491 (24%), Positives = 166/491 (33%), Gaps = 107/491 (21%)
Query: 1015 SKCSLYADSD------GENDSTSDSE-----SSSSSSSSSSSSSSSSSSSSSSSSESSSE 1063
S+CSL++ S G S S + SSSS + S S SS + S S+ S
Sbjct: 378 SRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGG 437
Query: 1064 DEEEEERPAALPSASPPP------------------------------------REVPVP 1087
E + E A S PPP R++ P
Sbjct: 438 SEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRP 497
Query: 1088 TPAPVE--------VPVPERVAGSPVTPLPEQEASPARPAGPT---EESPPSAPLRPPEP 1136
P P + VP+ G P P PE++ P P PT E +AP PP P
Sbjct: 498 PPPPRRTHSLHQRGLAVPDGPLGLP--PKPERKQQPQLPRPPTTGGSEGAGAAPC-PPNP 554
Query: 1137 -----PAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEP-----PPATP 1186
P P + RP P SP L P + +S+ P P PPA+P
Sbjct: 555 ANSWVPGLSPGGSRRP---PRSPERTLSP------SSGYSSQSGTPTLPPKGLAGPPASP 605
Query: 1187 PQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRG-RLTEEEEA 1245
+A+ P P + R ++ + L S P R G G R
Sbjct: 606 GKAQPPKPERVTSLRSPGASVSS-SLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHP 664
Query: 1246 EPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALA 1305
+ + PA L A V +T + P P + L+ + ++
Sbjct: 665 KVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVIS 724
Query: 1306 VKPTP---PAPALRPPEP--------VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQL 1354
+P P P+ PP P V AP+A S A+E L+ P P+ Q L
Sbjct: 725 KDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSA--SETAEEPLQDPNWPPPPPPAPEEQDL 782
Query: 1355 QQQREEGEEEG-------EEEGEEEEEE-SSDSSSSSDGEGALRRRSLRSHARRRRPPPP 1406
EE E G E S ++SS AL+ + S PPP
Sbjct: 783 SMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGS----PDPPPA 838
Query: 1407 PPPPPPRAYEP 1417
PP P P + P
Sbjct: 839 PPAPAPASSAP 849
Score = 51.6 bits (122), Expect = 6e-06
Identities = 92/343 (26%), Positives = 122/343 (35%), Gaps = 60/343 (17%)
Query: 1041 SSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP---PREVPVPTPAPVE---- 1093
S S S S + + E E P+A +A P P P P PAP E
Sbjct: 724 SKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLS 783
Query: 1094 ---VPVPERVAGSPVTPLPE-QEASPARPAGPTEESPPSAPLR-----PPEPPAGPPAPA 1144
P PE S +P P SP + P S + L+ P+PP PPAPA
Sbjct: 784 MADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPA 843
Query: 1145 PR----------PDERPSSPIPLLPPPKKR--RKTVSFSAIEVV-------PAPEPPPAT 1185
P P + P PP++ V+ S +++V P P PA
Sbjct: 844 PASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPAL 903
Query: 1186 PPQAKFPGPASRKAPRGVERTIRNLPLD------HASLVKSWPEEVSRGGRSRAGGRGRL 1239
P A P R+A G R P+ HA++ + G S A G
Sbjct: 904 GPSA--PQKPLRRALSG-----RASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNG-- 954
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLE 1299
EAEP A A + R L +E + ET + +R + E
Sbjct: 955 --PPEAEPRPPQSPASTASFIFSKGSRKLQ----LERPVSPETQADLQRNLVAELRSISE 1008
Query: 1300 HNYALAVKPTPPAP---ALRPPEPVPAPAALFSSPADEVLEAP 1339
A K +P AP A +P VP PA+ S P E L AP
Sbjct: 1009 QRPPQAPKKSPKAPPPVARKPSVGVPPPASP-SYPRAEPLTAP 1050
Score = 51.2 bits (121), Expect = 8e-06
Identities = 107/456 (23%), Positives = 155/456 (33%), Gaps = 73/456 (16%)
Query: 228 PAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTP-YSQDSA 286
P T++ +PG S + SSS PS + PQ TP R P + + A
Sbjct: 613 PERVTSLRSPGASVSSSLTSLCSSSSDPAPSD--RSGPQIL--TPLGDRFVIPPHPKVPA 668
Query: 287 YSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSS 346
S S KPR S N A + STT ++ + T T + S + S
Sbjct: 669 PFSPPPS---KPR-SPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVIS 724
Query: 347 SSSSSSSSSSSQFRSSD---------ANYPAYYESWNRYQRHTSYPPRRATREEPPGAPF 397
S S + P+ E+ + ++PP PP AP
Sbjct: 725 KDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPP------PPPPAPE 778
Query: 398 AENTAER-FPP---SYTSYLPPEPSRP-----------------TDQDYRPPASEAPPPE 436
++ + FPP ++ S PEP+ P T +PP S PPP
Sbjct: 779 EQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPA 838
Query: 437 PPEPGGGGGGGG---PSPEREEVRTSPRPASPARSGSPAPETT----------------N 477
PP P G P++E V S + P R AP T
Sbjct: 839 PPAPAPASSAPGHVAKLPQKEPVGCS-KGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGG 897
Query: 478 ESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARD-TGSEVPSGSGH 536
P S+ + L + S +S + L A + S P+G
Sbjct: 898 APTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPE 957
Query: 537 GPCTPPPAPANFED-VAPTGSGEPGATRE-SPKANGQNQASPCSSGDDMEISDDDRGGSP 594
PP +PA+ + GS + R SP+ Q + + + IS+ +P
Sbjct: 958 AEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQRNLVA--ELRSISEQRPPQAP 1015
Query: 595 ---PPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPP 627
P AP P + P PPP P Y + PL PP
Sbjct: 1016 KKSPKAPPPVARKPSVGVPPPASPSYPRAEPLTAPP 1051
Score = 44.7 bits (104), Expect = 8e-04
Identities = 75/356 (21%), Positives = 110/356 (30%), Gaps = 62/356 (17%)
Query: 900 PSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSF 959
P ++AS + P P T ++ P K+ P P PP T+ K
Sbjct: 696 PVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSP---PPSYHPPPPPTK-KPEVVV 751
Query: 960 ALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSL 1019
S E A + E++D A +E S E + S L
Sbjct: 752 EAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPEL 811
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP 1079
+ + S + + S + + + +SS+ + ++E P
Sbjct: 812 VSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKE---PVGCSKGGG 868
Query: 1080 PPRE---VPVPTP------------APVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
PPRE P+ TP AP P P +P PL + A P P
Sbjct: 869 PPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPV-PAPS 927
Query: 1125 SPPSAPLR------------PPEPPAGPPAPAPRPDERPSSPI---------------PL 1157
S A +R P GPP PRP + P+S P+
Sbjct: 928 SGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPV 987
Query: 1158 LPPPK---KRRKTVSFSAIEVVPAPE---------PPPATPPQAKFPGPASRKAPR 1201
P + +R +I P+ PP A P P PAS PR
Sbjct: 988 SPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPR 1043
Score = 33.1 bits (74), Expect = 2.4
Identities = 28/104 (26%), Positives = 40/104 (38%), Gaps = 17/104 (16%)
Query: 925 PEQEKEAGEPGRPGTKPPKRDEERGKT---------QGKHRKSFALDSEGEEASQESSSE 975
P A EPG PG P ++ G + +GK RK A +EG E + +
Sbjct: 6 PPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGKRRKKKAAGAEGAEPA--APRA 63
Query: 976 KDEEDDEEDEEDEDREEAVDTTKKETEVSDGE------DEESDS 1013
K ED + + + R A K V G+ DE D+
Sbjct: 64 KKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVDEHQDN 107
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 86.3 bits (212), Expect = 2e-16
Identities = 79/301 (26%), Positives = 100/301 (33%), Gaps = 71/301 (23%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPP--PEPPEP 440
PP + PP P N + PP P +P P Q + + +PP P+ P P
Sbjct: 72 PPPPGKPQGPP--PQGGNKPQGPPP------PGKPQGPPPQGDKSRSPRSPPGKPQGPPP 123
Query: 441 GGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQR 500
GG GP P + + P G P P P + S SR
Sbjct: 124 QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSR--------- 174
Query: 501 SKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPG 560
P G+ P PPP P + P G +P
Sbjct: 175 ---------------------SPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP- 212
Query: 561 ATRESPKANGQNQASPCSSGDDMEISDDDRG---GSPPPAPTPPQQPPPPPPPPPPPPPY 617
+ P G+ Q P + + + G G PP PQ PPPPP P PPP
Sbjct: 213 ---QGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 269
Query: 618 LASLPLGYPPHQPAYLLPP--------------RPDGPPP-----PEYPPPPP-----PP 653
+ P G PP PP +P GPPP P+ PPPPP PP
Sbjct: 270 GGNKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP 329
Query: 654 P 654
P
Sbjct: 330 P 330
Score = 84.7 bits (208), Expect = 7e-16
Identities = 103/425 (24%), Positives = 133/425 (31%), Gaps = 101/425 (23%)
Query: 392 PPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSP 451
P GAP + PPS P +P P Q P + PPP P +P G GG P
Sbjct: 36 PQGAPPQGGNKPQGPPSP----PGKPQGPPPQGGNQP--QGPPPPPGKPQGPPPQGGNKP 89
Query: 452 EREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTE 511
+ P P + P P+ P +
Sbjct: 90 QG--------PPPPGKPQGPPPQGDKSRSPRSPPGKPQGP-------------------- 121
Query: 512 EEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQ 571
P G+ P PPP P + P G +P + P G+
Sbjct: 122 -------------------PPQGGNQPQGPPPPPGKPQGPPPQGGNKP----QGPPPPGK 158
Query: 572 NQASPCSSGDDMEISDDDRG---GSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPP- 627
Q P + S G G PP PQ PPPPP P PPP + P G PP
Sbjct: 159 PQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP 218
Query: 628 -------------HQPAYLLPPRPDGPPP-----PEYPPPPP-----PPPHIYDFVNSLE 664
Q A P +P GPPP P+ PPPPP PPP +
Sbjct: 219 GKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGN------ 272
Query: 665 LMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEA 724
G G P Q +R + GK GPP + P PPP +
Sbjct: 273 --KPQGPPPPGKPQGPPPQGGSKSRSSRSPPGK-----PQGPPPQGGNQPQGPPPPPGKP 325
Query: 725 AYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKT 784
P G + +G P P S+ + + PP++E +G
Sbjct: 326 QGPPPQG----GNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381
Query: 785 LPTAG 789
P G
Sbjct: 382 PPAGG 386
Score = 76.3 bits (186), Expect = 2e-13
Identities = 80/316 (25%), Positives = 99/316 (31%), Gaps = 86/316 (27%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQ-DYRPPASEAPP--PEPPE 439
PP + PP P N + PP P +P P Q D + +S +PP P+ P
Sbjct: 133 PPPPGKPQGPP--PQGGNKPQGPPP------PGKPQGPPPQGDNKSRSSRSPPGKPQGPP 184
Query: 440 PGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQ 499
P GG GP P + + P G P P P + S +R
Sbjct: 185 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPP----- 239
Query: 500 RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEP 559
+ G P G+ P PPP P + P G +P
Sbjct: 240 -----------------------GKPQGP--PPQGGNQPQGPPPPPGKPQGPPPQGGNKP 274
Query: 560 GATRESPKANGQNQASPCSSGDDMEISDDDRG---GSPPPAPTPPQQPPPPPPPPPPPPP 616
+ P G+ Q P G S G G PP PQ PPPPP P PPP
Sbjct: 275 ----QGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP 330
Query: 617 YLASLPLGYPPHQPAYLLPPR-------------------------PDGPPPPE------ 645
+ P G PP PP+ P GPPPP
Sbjct: 331 QGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQ 390
Query: 646 -------YPPPPPPPP 654
P PP PP
Sbjct: 391 PQAPPAGQPQGPPRPP 406
Score = 60.5 bits (145), Expect = 1e-08
Identities = 43/124 (34%), Positives = 50/124 (40%), Gaps = 27/124 (21%)
Query: 558 EPGATRESPKA-NGQNQASPCSSGDDMEISDDDRG---GSPPPAPTPPQQPPPPPPPPPP 613
E + ESP G Q +P G+ + G G PP PQ PPPPP P
Sbjct: 21 EDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQG 80
Query: 614 PPPYLASLPLGYPPHQPAYLLPP-------------RPDGPPP-----PEYPPPPP---- 651
PPP + P G PP PP +P GPPP P+ PPPPP
Sbjct: 81 PPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 140
Query: 652 -PPP 654
PPP
Sbjct: 141 GPPP 144
Score = 59.3 bits (142), Expect = 3e-08
Identities = 32/90 (35%), Positives = 40/90 (44%), Gaps = 5/90 (5%)
Query: 568 ANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPP 627
++ QN S + + + G+PP PQ PP PP P PPP + P G PP
Sbjct: 14 SSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPP 73
Query: 628 HQPAYLLPP-----RPDGPPPPEYPPPPPP 652
PP +P GPPPP P PPP
Sbjct: 74 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPP 103
Score = 56.6 bits (135), Expect = 2e-07
Identities = 83/390 (21%), Positives = 128/390 (32%), Gaps = 103/390 (26%)
Query: 1056 SSSESSSEDEEEEERPAAL---PSASPPPR-EVPVPTPAPVEVPVPERVAGSPVTPLPE- 1110
SS+++ +ED +EE P+ + P +PP P P+P G P P P+
Sbjct: 14 SSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSP---------PGKPQGPPPQG 64
Query: 1111 --QEASPARPAGPTEESPPSAPLRP--PEPPAGPPAPAPRPDE--RPSSP--IPLLPPPK 1162
Q P P G + PP +P P PP P P P+ D+ P SP P PPP+
Sbjct: 65 GNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQ 124
Query: 1163 KRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWP 1222
+ P+ PP P + + P P P+G P
Sbjct: 125 GGNQ------------PQGPPPPPGKPQGPPPQGGNKPQGPP-----------------P 155
Query: 1223 EEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATET 1282
+G + + R + +P +G P +
Sbjct: 156 PGKPQGPPPQGDNKSRSSRSPPGKP------------------QGPPPQGGNQPQGPPPP 197
Query: 1283 SDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVV 1342
+ + P P + KP P P +P P P D ++
Sbjct: 198 PGKPQGPPPQGGN-----------KPQGPPPPGKPQGPPP--------QGDNKSQSARSP 238
Query: 1343 VAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDG-------EGALRRRSLR 1395
+ + P PQ Q + G+ +G + + G +G + RS R
Sbjct: 239 PGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSSR 298
Query: 1396 SHARRRRPPPP--------PPPPPPRAYEP 1417
S + + PPP PPPPP + P
Sbjct: 299 SPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328
Score = 52.4 bits (124), Expect = 4e-06
Identities = 46/197 (23%), Positives = 68/197 (34%), Gaps = 23/197 (11%)
Query: 1027 NDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPV 1086
N+ S ES S + + + + + + + P PPP P
Sbjct: 20 NEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQ 79
Query: 1087 PTPA-----PVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPA--- 1138
P P P P + G P P ++ SP P G + PP +P PP
Sbjct: 80 GPPPQGGNKPQGPPPPGKPQGPP--PQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPG 137
Query: 1139 GPPAPAPRPDERPSSP----IPLLPPPKKRRKTVSFSAIEVVP---------APEPPPAT 1185
P P P+ +P P P PPP+ K+ S + P P+ PP
Sbjct: 138 KPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP 197
Query: 1186 PPQAKFPGPASRKAPRG 1202
P + + P P P+G
Sbjct: 198 PGKPQGPPPQGGNKPQG 214
Score = 51.6 bits (122), Expect = 6e-06
Identities = 43/166 (25%), Positives = 60/166 (36%), Gaps = 21/166 (12%)
Query: 1048 SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107
+ S S+ S + + +P P PPP + P P P G P P
Sbjct: 230 NKSQSARSPPGKPQGPPPQGGNQPQGPP---PPPGKPQGPPPQGGNKPQGPPPPGKPQGP 286
Query: 1108 LPE-------QEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIP---- 1156
P+ + P +P GP + + P PP PP P P P+ +P P P
Sbjct: 287 PPQGGSKSRSSRSPPGKPQGPPPQGG-NQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKP 345
Query: 1157 LLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRG 1202
PPP+ K+ S +P P PPQ + P P G
Sbjct: 346 QGPPPQGGSKSRS------ARSPPGKPQGPPQQEGNNPQGPPPPAG 385
Score = 46.6 bits (109), Expect = 2e-04
Identities = 44/174 (25%), Positives = 62/174 (35%), Gaps = 22/174 (12%)
Query: 1048 SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107
+ S SS S + + +P P PPP + P P P G P P
Sbjct: 168 NKSRSSRSPPGKPQGPPPQGGNQPQGPP---PPPGKPQGPPPQGGNKPQGPPPPGKPQGP 224
Query: 1108 LPE---QEASPARPAGPTEESPPSAPLRPPEPPA---GPPAPAPRPDERPSSP----IPL 1157
P+ + S P G + PP +P PP P P P+ +P P P
Sbjct: 225 PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 284
Query: 1158 LPPPKKRRKTVSFSAIEVVP---------APEPPPATPPQAKFPGPASRKAPRG 1202
PPP+ K+ S + P P+ PP P + + P P P+G
Sbjct: 285 GPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 338
Score = 43.5 bits (101), Expect = 0.002
Identities = 35/111 (31%), Positives = 44/111 (39%), Gaps = 12/111 (10%)
Query: 1048 SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107
S S SS S + + +P P PPP + P P P G P P
Sbjct: 292 SKSRSSRSPPGKPQGPPPQGGNQPQGPP---PPPGKPQGPPPQGGNKPQGPPPPGKPQGP 348
Query: 1108 LPEQEASPARPAGPTEESPPSAPLRPPEP----PAGPPAPAPRPDERPSSP 1154
P Q S +R A SPP P PP+ P GPP PA ++P +P
Sbjct: 349 -PPQGGSKSRSA----RSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAP 394
Score = 32.3 bits (72), Expect = 4.0
Identities = 24/93 (25%), Positives = 33/93 (35%), Gaps = 11/93 (11%)
Query: 383 PPRRATREE---PPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPE-PP 438
PP+ + + PPG P + PP P + PP E P+ PP
Sbjct: 329 PPQGGNKPQGPPPPGKP-------QGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPP 381
Query: 439 EPGGGGGGGGPSPEREEVRTSPRPASPARSGSP 471
P GG +P + + PRP R P
Sbjct: 382 PPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSRP 414
>gi|197313748 SET domain containing 2 [Homo sapiens]
Length = 2564
Score = 85.9 bits (211), Expect = 3e-16
Identities = 42/128 (32%), Positives = 69/128 (53%), Gaps = 1/128 (0%)
Query: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
WGL A + + ++ V+EY G+ + R K Y + Y + +D IIDAT+ G
Sbjct: 1562 WGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKG 1621
Query: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFPLEDNKI-PCLCG 1698
N +RF+NH C PNC + T+ Q ++ ++ + + E+T+DY+F + C CG
Sbjct: 1622 NCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCG 1681
Query: 1699 TESCRGSL 1706
+ +CRG L
Sbjct: 1682 SANCRGYL 1689
Score = 42.7 bits (99), Expect = 0.003
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Query: 969 SQESSSEKDEEDDE-EDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGEN 1027
S E+ +++D + E+ + E D + K+ + G+DEE SSK SL G
Sbjct: 249 SLEADTKQDTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSK 308
Query: 1028 DSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEE 1069
+S SE S S S +SSS S + S+ E+E +
Sbjct: 309 KKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERD 350
Score = 38.5 bits (88), Expect = 0.056
Identities = 41/165 (24%), Positives = 64/165 (38%), Gaps = 31/165 (18%)
Query: 398 AENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVR 457
A TA PP++ + LP + T D PP+S PP PP P P+P E V
Sbjct: 158 ATTTAVASPPTHAAPLPAVIAESTTVD-SPPSS---PPPPPPPAQATTLSSPAPVTEPVA 213
Query: 458 TSPRPASPARSGSPAPETTNESVPFAQH--------------------SSLDSRIEMLLK 497
P + +P P + +V + +SL+ + +L
Sbjct: 214 LPHTPIT-VLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQILN 272
Query: 498 EQ-----RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHG 537
EQ + + S + D EE ++S + L + TGS+ S G
Sbjct: 273 EQADISSKKEDSHIGKD-EEIPDSSKISLSCKKTGSKKKSSQSEG 316
Score = 37.4 bits (85), Expect = 0.13
Identities = 52/270 (19%), Positives = 89/270 (32%), Gaps = 51/270 (18%)
Query: 962 DSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSS------ 1015
+S G + + + E +D+EE D + E + + K ++SD + DS
Sbjct: 1964 ESNGTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKEVY 2023
Query: 1016 KCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALP 1075
+ + ++ EN +T + + + + + S + + E+ + R + P
Sbjct: 2024 RIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRRSSLSP 2083
Query: 1076 SASPPPREVPVP-----TPAP--------------------VEVPVPERVAGSP------ 1104
+S R P TP E V +R A
Sbjct: 2084 PSSAYERGTKRPDDRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQN 2143
Query: 1105 ---VTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPA-----PAPRPDERPSSPIP 1156
+PLP P P PP P++ P+ P A P P D S
Sbjct: 2144 LGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSMDPVCS---- 2199
Query: 1157 LLPPPKKRRKTVSFSAIEVVPAPEPPPATP 1186
P P + + + E + AP P P P
Sbjct: 2200 --PAPYDHAQPLVGHSTEPLSAPPPVPVVP 2227
Score = 35.4 bits (80), Expect = 0.48
Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 15/73 (20%)
Query: 1100 VAGSPVTPLPEQEASPARPAGP---------TEESPPSAPLRPPEPPA-----GPPAPAP 1145
V P+ ASP A P T +SPPS+P PP PPA PAP
Sbjct: 151 VTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDSPPSSP-PPPPPPAQATTLSSPAPVT 209
Query: 1146 RPDERPSSPIPLL 1158
P P +PI +L
Sbjct: 210 EPVALPHTPITVL 222
Score = 34.7 bits (78), Expect = 0.82
Identities = 56/238 (23%), Positives = 87/238 (36%), Gaps = 50/238 (21%)
Query: 434 PPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIE 493
P PP+ G P+PE EE + + ++G + V ++ ++ +
Sbjct: 6 PQPPPKMGDFYDPEHPTPEEEE--NEAKIENVQKTGF-IKGPMFKGVASSRFLPKGTKTK 62
Query: 494 MLLKEQ-RSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVA 552
+ L+EQ R K SF S T++ +N + + S+ P+ PPA D
Sbjct: 63 VNLEEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPN---------PPAVPLQVDST 113
Query: 553 PTGSGEPGATRESPKANGQNQASPCSSGDDME----------------ISDDDRGGSPPP 596
P E G T + + ++SP S ++ ++ SPP
Sbjct: 114 PKMKMEIGDTLSTAE-----ESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPT 168
Query: 597 --APTPPQ-------QPPPPPPPPPPPPPYLASLPLGYP-------PHQPAYLLPPRP 638
AP P PP PPPPPPP +L P PH P +L P
Sbjct: 169 HAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAP 226
Score = 33.9 bits (76), Expect = 1.4
Identities = 55/257 (21%), Positives = 95/257 (36%), Gaps = 34/257 (13%)
Query: 149 KETVKNLHLTSVMGNIIHAQLDIKGQQRMKYY----ELIVNGSYTPQTVPTGGKALSEKF 204
++T+ N L + I++ Q DI ++ + E+ + + TG K S +
Sbjct: 256 QDTISN-SLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQS 314
Query: 205 QGSGAATETAESRRRSSSDTAAY-------------------PAGTTAVGTPGNGTPCSQ 245
+G +E+ E R+SS ++ P + +G P
Sbjct: 315 EGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRD 374
Query: 246 DTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSY 305
D FS S+ + + + +S + R S +S+ S + S S RSE S+
Sbjct: 375 DKYFSYSKLERDTRYVSSRCRSER----ERRRSRSHSRSERGSRTNLSYS----RSERSH 426
Query: 306 QDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDAN 365
RR+ +S + T SS S + S +SS SS +R D
Sbjct: 427 YYDSDRRYHRSSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYR--DLR 484
Query: 366 YPAYYESWNRYQRHTSY 382
+Y +S + TSY
Sbjct: 485 TSSYSKSDRDCKTETSY 501
Score = 33.5 bits (75), Expect = 1.8
Identities = 54/263 (20%), Positives = 84/263 (31%), Gaps = 21/263 (7%)
Query: 884 LRGALRLPSFKVKRKEPSEISEASE-----EKRPRPSTPAEEDEDDPEQEKEAGE--PGR 936
L+ R+P KE + + ++ P P TP E DP+++ + E R
Sbjct: 2019 LKEVYRIPKKSQTEKENTTTERGRDAVGFRDQTPAPKTPNRSRERDPDKQTQNKEKRKRR 2078
Query: 937 PGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDT 996
PP ERG + R +S +K D E+R + +
Sbjct: 2079 SSLSPPSSAYERGTKRPDDR-----------YDTPTSKKKVRIKDRNKLSTEERRKLFEQ 2127
Query: 997 TKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSS 1056
+ E + + + L DS G N + S+ ++
Sbjct: 2128 EVAQREAQKQQQQMQNLGMTSPLPYDSLGYNAPHHPFAGYPPGYPMQAYVDPSNPNAGKV 2187
Query: 1057 SSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPA 1116
+ S D PA A P P AP VPV VA +PV Q + +
Sbjct: 2188 LLPTPSMDPVCS--PAPYDHAQPLVGHSTEPLSAPPPVPVVPHVA-APVEVSSSQYVAQS 2244
Query: 1117 RPAGPTEESPPSAPLRPPEPPAG 1139
+ S P+ P P G
Sbjct: 2245 DGVVHQDSSVAVLPVPAPGPVQG 2267
Score = 32.7 bits (73), Expect = 3.1
Identities = 42/227 (18%), Positives = 77/227 (33%), Gaps = 8/227 (3%)
Query: 925 PEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDS--EGEEASQESSSEKDEEDDE 982
P+ + G+ P P+ +E K + + F +G +S+ + +
Sbjct: 6 PQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNL 65
Query: 983 EDEEDEDREEAVDTTKKETE----VSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSS 1038
E++ + + TKK + + G +++SD+ + ++ D + + S
Sbjct: 66 EEQGRQKVSFSFSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLS 125
Query: 1039 SSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPE 1098
++ SS S + ASPP P+P V
Sbjct: 126 TAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAESTTVDS 185
Query: 1099 RVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAP 1145
+ P P P Q + + PA TE P + P P P P P
Sbjct: 186 PPSSPPPPPPPAQATTLSSPAPVTE--PVALPHTPITVLMAAPVPLP 230
Score = 32.0 bits (71), Expect = 5.3
Identities = 41/161 (25%), Positives = 64/161 (39%), Gaps = 20/161 (12%)
Query: 1240 TEEEEAEPGTEVDLAVL---ADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHI 1296
T EE + P + V+L + L +R L AV A+ + A P +
Sbjct: 126 TAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAV----ASPPTHAAPLPAVIAEST 181
Query: 1297 LLEHNYALAVKPTPPAPA--LRPPEPVPAPAALFSSPADEVLEAP-----EVVVAEAEEP 1349
++ + P PPA A L P PV P AL +P ++ AP +V V +EP
Sbjct: 182 TVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEP 241
Query: 1350 K----PQQLQQQREEG--EEEGEEEGEEEEEESSDSSSSSD 1384
P+ L+ ++ EE + E +D SS +
Sbjct: 242 PIIIVPESLEADTKQDTISNSLEEHVTQILNEQADISSKKE 282
Score = 32.0 bits (71), Expect = 5.3
Identities = 68/294 (23%), Positives = 106/294 (36%), Gaps = 38/294 (12%)
Query: 336 SSSASSSSLSSSSSSSSS----SSSSQFRSSDANYPAY--------YESWNRYQRHTSYP 383
SSS S L S+S SS+ +S D P+ Y S+++ +R T Y
Sbjct: 331 SSSQRSHDLKFSASIEKERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYV 390
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYR----PPASEAPPPEPPE 439
R E + + +ER + SY E S D D R P E P
Sbjct: 391 SSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPY 450
Query: 440 PGGGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQ 499
S E E +T R S S T++ S + S +EM E+
Sbjct: 451 TDNRARESSDS-EEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEM---ER 506
Query: 500 RSKFSF-LASDTEEEEENSSM--------VLGARDTGS---EVPSGSGHGPCTPPPAPAN 547
R K+S L +++ EN ++ LG R S S S + P P +
Sbjct: 507 RGKYSSKLERESKRTSENEAIKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKS 566
Query: 548 FEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEI----SDDDRGGSPPPA 597
D E +++ + +PCS G ++ + + ++ GSP P+
Sbjct: 567 --DKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPS 618
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 84.7 bits (208), Expect = 7e-16
Identities = 120/461 (26%), Positives = 150/461 (32%), Gaps = 121/461 (26%)
Query: 1050 SSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPT-PAPVEVPVPERVAGSPVTPL 1108
S S E SS E AAL PP + PT P P VP PE A SP
Sbjct: 606 SLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPE--APSPF--- 660
Query: 1109 PEQEASPARPAGPTEESPPSAPLRPPEPPAGP-PAPAPRPDERPSSP------------- 1154
A P P GP S S P P P AGP P+ P P RP P
Sbjct: 661 ---RAPPFHPPGPMP-SVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGL 716
Query: 1155 --IP--LLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNL 1210
+P LLP P+ R + I + P+ PPP PP F G R A
Sbjct: 717 VSVPPRLLPGPENHRAGSNEDPI-LAPSGTPPPTIPPDETFGGRVPRPA----------- 764
Query: 1211 PLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPA 1270
+ ++E E+ L +D ++ GLP
Sbjct: 765 ---------------------------FVHYDKEEASDVEISLESDSDDSVVIVPEGLPP 797
Query: 1271 LPAVEDSEATETSDEAERPRPLLSHI-LLEHNYALAVKPTPPAPALRPPEPVPAPAAL-- 1327
LP S AT P + E L P P P PP PVP P L
Sbjct: 798 LPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPP 857
Query: 1328 -------------------------FSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGE 1362
+S +E E E E EE + ++ ++ EE E
Sbjct: 858 PQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDE 917
Query: 1363 EEGEEEGEEEEEESSDSSSSSDGE-------------------GALRRRSLRSHARRRRP 1403
EE EE EEEEEE + +GE L + P
Sbjct: 918 EEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAP 977
Query: 1404 PPP------PPPPPPRAYEPRSEFEQMTILYDIWNSGLDSE 1438
PPP PPP P +P E E +L ++ G + E
Sbjct: 978 PPPTLPPALPPPESPPKVQPEPEPEP-GLLLEVEEPGTEEE 1017
Score = 73.9 bits (180), Expect = 1e-12
Identities = 70/282 (24%), Positives = 101/282 (35%), Gaps = 28/282 (9%)
Query: 906 ASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEG 965
A EE P+ P P G P T PP + G G + E
Sbjct: 825 AKEEPEELPAAPGPLPPPPPPPPPVPG----PVTLPPPQLVPEGTPGGGGPPAL---EED 877
Query: 966 EEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDG 1025
+SS+++EE++EE+EE+E+ EE + +E E + E E + + + +
Sbjct: 878 LTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEE 937
Query: 1026 ENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVP 1085
E + E ++ E P ALP PP+ P
Sbjct: 938 EEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQP 997
Query: 1086 VPTPAP-----VEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGP 1140
P P P VE P E G+ P EA P++ G E R E PA
Sbjct: 998 EPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQ--GEVE--------REGESPAAG 1047
Query: 1141 PAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP 1182
P P +E PS+P LL + + +V P PE P
Sbjct: 1048 PPPQELVEEEPSAPPTLL------EEETEDGSDKVQPPPETP 1083
Score = 71.2 bits (173), Expect = 8e-12
Identities = 107/420 (25%), Positives = 139/420 (33%), Gaps = 106/420 (25%)
Query: 1069 ERPAALPSASPPPREVP-------VPTPA----------PVEVPVPERVAGSPVTPLPEQ 1111
E P PS +PPP P VP PA VE+ + E + V +PE
Sbjct: 736 EDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISL-ESDSDDSVVIVPEG 794
Query: 1112 EASPARPAGPTEESPPSAPLRPPEPP-AGPPAPAPR-PDERPSSPIPLLPPPKKRRKTVS 1169
P P P+ +PP P+ P PP A PP PA P+E P++P PL PPP
Sbjct: 795 -LPPLPPPPPSGATPP--PIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPP------ 845
Query: 1170 FSAIEVVPAPEPPPAT--PPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSR 1227
P P P P T PPQ G P +E + + ++ + + EE
Sbjct: 846 -------PPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEE 898
Query: 1228 GGRSRAGGRGRLTEEEEAEPGT---------------EVDLAVLADLALTPARRGLPALP 1272
EEEE E E + L + L
Sbjct: 899 EEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELE 958
Query: 1273 AVEDSEATETSDEAER---PRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALFS 1329
VED E E E P P L L P P +P PEP P P L
Sbjct: 959 EVEDLEFGTAGGEVEEGAPPPPTLPPAL----------PPPESPPKVQPEPEPEPGLLLE 1008
Query: 1330 SPADEVLE----------APEVVVAEAEE----------PKPQQLQQQR--------EEG 1361
E APE + ++ E P PQ+L ++ EE
Sbjct: 1009 VEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEE 1068
Query: 1362 EEEG------------EEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPP 1409
E+G EEE E E E + D A+ + +PPPP P
Sbjct: 1069 TEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEP 1128
Score = 61.2 bits (147), Expect = 8e-09
Identities = 82/339 (24%), Positives = 106/339 (31%), Gaps = 80/339 (23%)
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSR--PTDQDYRP-PASEAPPPEPPE 439
PP AT PP AP TA PP P++ P + P P PPP PP
Sbjct: 802 PPSGAT--PPPIAPTGPPTAS----------PPVPAKEEPEELPAAPGPLPPPPPPPPPV 849
Query: 440 PG------------GGGGGGGP-----------------SPEREEVRTSPRPASPARSGS 470
PG G GGGGP E EE
Sbjct: 850 PGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEED 909
Query: 471 PAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARD---TG 527
E +E F + + E +E+ + + +EEEE + + G
Sbjct: 910 FEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAG 969
Query: 528 SEVPSGSGHGPCTPP--PAPANFEDVAPTGSGEPG--------ATRESPKANGQNQASP- 576
EV G+ P PP P P + V P EPG T E A+ +P
Sbjct: 970 GEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE 1029
Query: 577 -CSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPP-------------PPPPPPPYLASLP 622
S ++E + PPP ++P PP PPP P +
Sbjct: 1030 ALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEME 1089
Query: 623 LGYPPH--------QPAYLLPPRPDGPPPPEYPPPPPPP 653
A +L D PP E PPPP P
Sbjct: 1090 TETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEP 1128
Score = 60.8 bits (146), Expect = 1e-08
Identities = 67/262 (25%), Positives = 86/262 (32%), Gaps = 48/262 (18%)
Query: 401 TAERFPPSYTSYLPPEPSRPTDQDYRPPASEAP-------PPEPPEPGGGGGGGGPSPER 453
T R PP P P+ PT PP + +P PP P G GP P
Sbjct: 631 THPRVPPLQ----PMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPS- 685
Query: 454 EEVRTSPRP-ASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512
P P A P S P P TT + + + +L + +
Sbjct: 686 ----AGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHR---------- 731
Query: 513 EEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQN 572
G+ + PSG TPPP E + +A+
Sbjct: 732 --------AGSNEDPILAPSG------TPPPTIPPDETFGGRVPRPAFVHYDKEEASDVE 777
Query: 573 QASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAY 632
+ S D + I + G PP P PP PPP P PP +P P +
Sbjct: 778 ISLESDSDDSVVIVPE---GLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEE--- 831
Query: 633 LLPPRPDGPPPPEYPPPPPPPP 654
LP P PPP PPPP P P
Sbjct: 832 -LPAAPGPLPPPPPPPPPVPGP 852
Score = 57.8 bits (138), Expect = 9e-08
Identities = 67/264 (25%), Positives = 102/264 (38%), Gaps = 34/264 (12%)
Query: 901 SEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFA 960
S+ E EE+ EE+E+D E+E+E DEE + +
Sbjct: 886 SDEEEEEEEEEEEEEEEEEEEEEDFEEEEE--------------DEEEYFEEEEEE---- 927
Query: 961 LDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020
+ E EE +E E +EE++EEDEE+E+ E V+ E + GE EE
Sbjct: 928 -EEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDL--EFGTAGGEVEEGAPPPPTLPP 984
Query: 1021 ADSDGENDSTSDSESSSSSS-----SSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALP 1075
A E+ E + + ++ + + + + E ER P
Sbjct: 985 ALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESP 1044
Query: 1076 SASPPPREVPVPTP-APVEVPVPERVAGS-PVTPLPEQEASPARPAGPTEESPPSAPLRP 1133
+A PPP+E+ P AP + E GS V P PE +PA TE + +
Sbjct: 1045 AAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPE---TPAEEEMETETEAEALQEKE 1101
Query: 1134 PEPPAGPPA---PAPRPDERPSSP 1154
+ A A P DE+P P
Sbjct: 1102 QDDTAAMLADFIDCPPDDEKPPPP 1125
Score = 51.6 bits (122), Expect = 6e-06
Identities = 115/539 (21%), Positives = 181/539 (33%), Gaps = 92/539 (17%)
Query: 516 NSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQAS 575
+ ++V A T VP GP P PAP V P P+A +A
Sbjct: 621 SEALVTCAALTHPRVPPLQPMGPTCPTPAP-----VPP------------PEAPSPFRAP 663
Query: 576 PCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYP--PHQPAYL 633
P M P P+ P P P P PP L L P P L
Sbjct: 664 PFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRL 723
Query: 634 LPP--------------RPDGPPPPEYPPPP------PPPPHIYDFVNSLELMDRLGAQW 673
LP P G PPP PP P P ++ D+ A
Sbjct: 724 LPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVH--------YDKEEASD 775
Query: 674 GGMPMSFQMQTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALY 733
+ + ++ +GL PP GA P PP + P
Sbjct: 776 VEISLESDSDDSVVI------VPEGLPPLPPPPPSGATPPPIAPTGPPTASP---PVPAK 826
Query: 734 AQGQEGRGAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGR 793
+ +E A P P+ P P V G PP+ E G P A
Sbjct: 827 EEPEELPAA--------PGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDL 878
Query: 794 VLAML-----VQEMKSIMQRDLNRKMVENVAFGA----FDQWWESKEEKAKPFQNAAKQ- 843
+ + +E + + + + E F ++++E +EE+ + F+ ++
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEE 938
Query: 844 --QAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPS 901
+ +EE++E+ + +E L + D GT G G GA P+ P
Sbjct: 939 EGELEEEEEEEDEEEEEELEEVED--LEFGTAG------GEVEEGAPPPPTLPPALPPPE 990
Query: 902 EISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFAL 961
+ E P P E +E P E+E G P T P+ +G+ + + A
Sbjct: 991 SPPKVQPEPEPEPGLLLEVEE--PGTEEERGADTAP-TLAPEALPSQGEVEREGESPAAG 1047
Query: 962 DSEGEEASQESSS-----EKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSS 1015
E +E S+ E++ ED + + A + + ETE +++E D ++
Sbjct: 1048 PPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTA 1106
>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
Length = 1970
Score = 84.0 bits (206), Expect = 1e-15
Identities = 108/449 (24%), Positives = 162/449 (36%), Gaps = 52/449 (11%)
Query: 206 GSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTP 265
GSG A ++SD + + G + +P G+P S S PS G +P
Sbjct: 1536 GSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSP----GPSSPYIPSPGGAMSP 1591
Query: 266 QSSQGTP-YTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTAS 324
S +P Y R Y+ S S S TS S+ P + SY S + S + + S
Sbjct: 1592 SYSPTSPAYEPRSPGGYTPQSP-SYSPTSPSYSP--TSPSYSPT-SPNYSPTSPSYSPTS 1647
Query: 325 TAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHT-SYP 383
+ + T+ + + +S S S S S S +S S S S P+Y + Y + SY
Sbjct: 1648 PSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS 1707
Query: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPS-RPTDQDYRPPASEAPPPEPPEPGG 442
P + P +P T+ + P+ SY P PS PT +Y P + P P
Sbjct: 1708 PTSPSYS--PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPT 1765
Query: 443 GGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSK 502
SP + P SP S SP + + + P
Sbjct: 1766 SPSYSPTSPNYTPTSPNYSPTSP--SYSPTSPSYSPTSP--------------------- 1802
Query: 503 FSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGAT 562
S+ S ++ + PS + P +P +P + + + S P +
Sbjct: 1803 -SYSPSSPRYTPQSPTYT----------PSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSP 1851
Query: 563 RESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLP 622
+P + + SP S + S SP +PT P+ P P P P Y + P
Sbjct: 1852 EYTPTSPKYSPTSPKYSPTSPKYSPT----SPTYSPTTPKYSPTSPTYSPTSPVYTPTSP 1907
Query: 623 LGYPPHQPAYLLPPRPDGPPPPEYPPPPP 651
Y P P Y P P Y P P
Sbjct: 1908 -KYSPTSPTYSPTSPKYSPTSPTYSPTSP 1935
Score = 72.4 bits (176), Expect = 4e-12
Identities = 92/396 (23%), Positives = 139/396 (35%), Gaps = 35/396 (8%)
Query: 264 TPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTA 323
TP +P G TP + + S+++ ++ F P Y A+S S S ++
Sbjct: 1525 TPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSP-----GYSPAWSPTPGSPGSPGPSS 1579
Query: 324 STAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANY----PAYYESWNRYQRH 379
+ A + S S +S + S + S + + +Y P+Y + Y
Sbjct: 1580 PYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPT 1639
Query: 380 T-SYPPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPS-RPTDQDYRPPASEAPPPEP 437
+ SY P + P +P T+ + P+ SY P PS PT Y P + P P
Sbjct: 1640 SPSYSPTSPSYS--PTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSP 1697
Query: 438 PEPGGGGGGGGPSPEREEVRTSPRPASPARSG-SPAPETTNESV-PFAQHSSLDSRIEML 495
SP S P SP+ S SP+ T+ S P + + S S
Sbjct: 1698 SYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTP 1757
Query: 496 LKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTG 555
S S S T + P+ + P +P +P + +
Sbjct: 1758 TSPSYSPTSPSYSPTSP---------------NYTPTSPNYSPTSPSYSPTSPSYSPTSP 1802
Query: 556 SGEPGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPP 615
S P + R +P++ +SP S S SP PT P P P P P
Sbjct: 1803 SYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPT----SPKYTPTSPSYSPSSPEYTPTSP 1858
Query: 616 PYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPP 651
Y + P Y P P Y P P+Y P P
Sbjct: 1859 KYSPTSP-KYSPTSPKYSPTSPTYSPTTPKYSPTSP 1893
Score = 67.0 bits (162), Expect = 1e-10
Identities = 97/425 (22%), Positives = 144/425 (33%), Gaps = 46/425 (10%)
Query: 237 PGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTP----YSQDSAYSSSTT 292
PG G F S+ PS G +P TP+ ++G+TP +S +
Sbjct: 1491 PGLGAAGPTGMFFGSA----PSPMGGISPAM---TPW-NQGATPAYGAWSPSVGSGMTPG 1542
Query: 293 STSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSS 352
+ F P + + AS S S A + T + S SS + S + S
Sbjct: 1543 AAGFSPSAASD------------ASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMS 1590
Query: 353 SSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAENTAERFPPSYTSY 412
S S + + P Y + SY P + P +P T+ + P+ SY
Sbjct: 1591 PSYSPTSPAYEPRSPGGYTP-----QSPSYSPTSPSYS--PTSPSYSPTSPNYSPTSPSY 1643
Query: 413 LPPEPS-RPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSP 471
P PS PT Y P + P P SP S P SP+ S +
Sbjct: 1644 SPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPT- 1702
Query: 472 APETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVP 531
+P + S ++ S S +S + N S + + P
Sbjct: 1703 SPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPT-----SPNYTP 1757
Query: 532 SGSGHGPCTPPPAPA--NFEDVAPTGSGEPGATRESPKANGQNQASPCSSGDDMEISDDD 589
+ + P +P +P N+ +P S P + SP + + SP S +
Sbjct: 1758 TSPSYSPTSPSYSPTSPNYTPTSPNYS--PTSPSYSPTSPSYSPTSPSYSPSSPRYTPQS 1815
Query: 590 ---RGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEY 646
SP +P+ P P P P P Y S P Y P P Y P P+Y
Sbjct: 1816 PTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSP-EYTPTSPKYSPTSPKYSPTSPKY 1874
Query: 647 PPPPP 651
P P
Sbjct: 1875 SPTSP 1879
Score = 49.3 bits (116), Expect = 3e-05
Identities = 42/177 (23%), Positives = 67/177 (37%), Gaps = 13/177 (7%)
Query: 1027 NDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPV 1086
N + + + S S S + ++ S S++S++S P P+ SP P
Sbjct: 1521 NQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFS------PGYSPAWSPTPGSPGS 1574
Query: 1087 PTPAPVEVPVPERVAG---SPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAP 1143
P P+ +P P SP +P E P P G T +SP +P P P P
Sbjct: 1575 PGPSSPYIPSPGGAMSPSYSPTSPAYE----PRSPGGYTPQSPSYSPTSPSYSPTSPSYS 1630
Query: 1144 APRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP 1200
P+ P+SP P + S+S +P P +P + + +P
Sbjct: 1631 PTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP 1687
Score = 47.8 bits (112), Expect = 9e-05
Identities = 49/192 (25%), Positives = 71/192 (36%), Gaps = 6/192 (3%)
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP 1079
Y+ + TS S S +S S S +S S S +S S S + S P + PS SP
Sbjct: 1650 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTS-PSYSP 1708
Query: 1080 --PPREVPVPTPAPVEVPV-PERVAGSPVTPLPEQEASPARPAGP--TEESPPSAPLRPP 1134
P P+ +P P + SP +P + P P T SP +P P
Sbjct: 1709 TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPS 1768
Query: 1135 EPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGP 1194
P P P+ P+SP P + S+S P+ P TP +
Sbjct: 1769 YSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPS 1828
Query: 1195 ASRKAPRGVERT 1206
+ +P + T
Sbjct: 1829 SPSYSPTSPKYT 1840
Score = 44.3 bits (103), Expect = 0.001
Identities = 47/184 (25%), Positives = 72/184 (39%), Gaps = 9/184 (4%)
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP 1079
Y+ + TS S S +S S S +S + + +S + S + S P + PS SP
Sbjct: 1748 YSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTS-PSYSP 1806
Query: 1080 P-PREVPV-PTPAPVEVPV-PERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEP 1136
PR P PT P P + SP +P + +P P+ + SP P P
Sbjct: 1807 SSPRYTPQSPTYTPSSPSYSPSSPSYSPTSP----KYTPTSPSY-SPSSPEYTPTSPKYS 1861
Query: 1137 PAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPAS 1196
P P P P+SP PK + ++S V P P +P + +
Sbjct: 1862 PTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSP 1921
Query: 1197 RKAP 1200
+ +P
Sbjct: 1922 KYSP 1925
Score = 44.3 bits (103), Expect = 0.001
Identities = 44/159 (27%), Positives = 61/159 (38%), Gaps = 5/159 (3%)
Query: 1035 SSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTP-APVE 1093
S + S +S S S +S S S +S S S S + P PS+ P +P +P
Sbjct: 1780 SPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKY 1839
Query: 1094 VPV-PERVAGSPVTPLPEQEASPARPA-GPTEESPPSAPLRPPEPPAGPPAPAPRPDERP 1151
P P SP + SP P PT SP +P P P P P P
Sbjct: 1840 TPTSPSYSPSSPEYTPTSPKYSPTSPKYSPT--SPKYSPTSPTYSPTTPKYSPTSPTYSP 1897
Query: 1152 SSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAK 1190
+SP+ PK + ++S +P P +P K
Sbjct: 1898 TSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPK 1936
Score = 42.0 bits (97), Expect = 0.005
Identities = 44/186 (23%), Positives = 68/186 (36%), Gaps = 6/186 (3%)
Query: 1020 YADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP 1079
Y+ + TS + S +S + + +S S S +S S S + + P + PS SP
Sbjct: 1734 YSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTS-PSYSP 1792
Query: 1080 --PPREVPVPTPAPVEVP-VPERVAGSPVTPLPEQEASPARPAGP--TEESPPSAPLRPP 1134
P P+ +P P+ +P +P + P P T SP +P P
Sbjct: 1793 TSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPE 1852
Query: 1135 EPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGP 1194
P P P P+SP P T +S +P P TP K+
Sbjct: 1853 YTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPT 1912
Query: 1195 ASRKAP 1200
+ +P
Sbjct: 1913 SPTYSP 1918
Score = 38.5 bits (88), Expect = 0.056
Identities = 40/172 (23%), Positives = 58/172 (33%), Gaps = 5/172 (2%)
Query: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090
S S +S +S S S + S + S S S A PS SP P P
Sbjct: 1547 SPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTS---PAYEPR 1603
Query: 1091 PVEVPVPERVAGSPVTPLPEQEASPARPAGP--TEESPPSAPLRPPEPPAGPPAPAPRPD 1148
P+ + SP +P + P P + SP +P P P P P
Sbjct: 1604 SPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPS 1663
Query: 1149 ERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAP 1200
P+SP P + S+S +P P +P + + +P
Sbjct: 1664 YSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP 1715
Score = 37.7 bits (86), Expect = 0.096
Identities = 43/141 (30%), Positives = 56/141 (39%), Gaps = 9/141 (6%)
Query: 1030 TSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAAL-PSASPP-PREVPV- 1086
T S S S SS S S +S + +S S S SS E + + P SP P+ P
Sbjct: 1819 TPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTS 1878
Query: 1087 PTPAPVEVPV-PERVAGSPVTPLPEQEASPARPAGPTEE--SP---PSAPLRPPEPPAGP 1140
PT +P P SP +P+ + P PT SP P++P P P G
Sbjct: 1879 PTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGS 1938
Query: 1141 PAPAPRPDERPSSPIPLLPPP 1161
P P+SP L P
Sbjct: 1939 TYSPTSPGYSPTSPTYSLTSP 1959
>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
[Homo sapiens]
Length = 2427
Score = 84.0 bits (206), Expect = 1e-15
Identities = 44/128 (34%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
Query: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
WGL I E V EYVG+ I + R + + I + Y+ +D D IIDA G
Sbjct: 1685 WGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKG 1744
Query: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
N ARF+NHCC PNC + ++ ++ +++ I E+T++Y L + K C CG
Sbjct: 1745 NYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCG 1804
Query: 1699 TESCRGSL 1706
+C G L
Sbjct: 1805 APNCSGFL 1812
Score = 36.2 bits (82), Expect = 0.28
Identities = 59/250 (23%), Positives = 92/250 (36%), Gaps = 43/250 (17%)
Query: 1056 SSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
+ S + S+ +RP P A PR P+PV P +SP
Sbjct: 2031 AGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSP----------------SSSP 2074
Query: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEV 1175
+ + P E +A R + G +P P+ E+ S P L PP R S +
Sbjct: 2075 SVRSQPLERPLGTADPR-LDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQT 2133
Query: 1176 VPAPEPPPATPPQAKFPGP------------ASRKAPRGVERTIRNLPLDHASLVKSWPE 1223
P P + P P A KA R V++ ++ + A+LV +
Sbjct: 2134 SDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQS--KNRAALVMDLID 2191
Query: 1224 EVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALP-AVED---SEA 1279
R + R + P + + VL + + PA +GL +P AVE S+
Sbjct: 2192 LTPR-------QKERAASPHQVTPQADEKMPVL-ESSSWPASKGLGHMPRAVEKGCVSDP 2243
Query: 1280 TETSDEAERP 1289
+TS +A P
Sbjct: 2244 LQTSGKAAAP 2253
>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
[Homo sapiens]
Length = 2696
Score = 84.0 bits (206), Expect = 1e-15
Identities = 44/128 (34%), Positives = 65/128 (50%), Gaps = 1/128 (0%)
Query: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
WGL I E V EYVG+ I + R + + I + Y+ +D D IIDA G
Sbjct: 1954 WGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKG 2013
Query: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
N ARF+NHCC PNC + ++ ++ +++ I E+T++Y L + K C CG
Sbjct: 2014 NYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCG 2073
Query: 1699 TESCRGSL 1706
+C G L
Sbjct: 2074 APNCSGFL 2081
Score = 36.2 bits (82), Expect = 0.28
Identities = 59/250 (23%), Positives = 92/250 (36%), Gaps = 43/250 (17%)
Query: 1056 SSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASP 1115
+ S + S+ +RP P A PR P+PV P +SP
Sbjct: 2300 AGSGTKSQSLVSSQRPLDRPPAVAGPRPQLSDKPSPVTSP----------------SSSP 2343
Query: 1116 ARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEV 1175
+ + P E +A R + G +P P+ E+ S P L PP R S +
Sbjct: 2344 SVRSQPLERPLGTADPR-LDKSIGAASPRPQSLEKTSVPTGLRLPPPDRLLITSSPKPQT 2402
Query: 1176 VPAPEPPPATPPQAKFPGP------------ASRKAPRGVERTIRNLPLDHASLVKSWPE 1223
P P + P P A KA R V++ ++ + A+LV +
Sbjct: 2403 SDRPTDKPHASLSQRLPPPEKVLSAVVQTLVAKEKALRPVDQNTQS--KNRAALVMDLID 2460
Query: 1224 EVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALP-AVED---SEA 1279
R + R + P + + VL + + PA +GL +P AVE S+
Sbjct: 2461 LTPR-------QKERAASPHQVTPQADEKMPVL-ESSSWPASKGLGHMPRAVEKGCVSDP 2512
Query: 1280 TETSDEAERP 1289
+TS +A P
Sbjct: 2513 LQTSGKAAAP 2522
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 83.2 bits (204), Expect = 2e-15
Identities = 211/1086 (19%), Positives = 353/1086 (32%), Gaps = 195/1086 (17%)
Query: 212 ETAE-SRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQG 270
+T+E R+R + + AA A T V P + + S++ + + + T S G
Sbjct: 55 QTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 271 TPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSEN--SYQDAFSRRHFSASSASTTASTAIA 328
S ++ + T ++ P + + S R + SA+TT +
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 329 ATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRAT 388
+ A +A+ + S+ + SSS + S + + + +S +T
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV----ST 230
Query: 389 REEPP--GAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGG 446
+E P AP + P LPP ++ + E E P G
Sbjct: 231 KESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 447 GGPSPEREEVRTSPRPA--SPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFS 504
S + +VR + PA +P + +PAP +V + +E S
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP-------EEDSESSS 343
Query: 505 FLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRE 564
+SD+EEE + +L A+ +G G+ P P + AP G+ G
Sbjct: 344 EESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR----KGAAPAPPGKTGPAVA 399
Query: 565 SPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLG 624
+A + + S SS E SD + + P P P AS P
Sbjct: 400 KAQAGKREEDSQSSS----EESDSEE-----------EAPAQAKPSGKAPQVRAASAPAK 444
Query: 625 YPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQMQT 684
P + A PPR GP + S + L A M
Sbjct: 445 ESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA----------MNA 494
Query: 685 QMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYS 744
+ L + Q K GP G G PP + P A + +E + S
Sbjct: 495 AQVKPLGKSPQVKPASTMGMGPLGKGAGPV-----PPGKVGPATPSAQVGKWEEDSESSS 549
Query: 745 REAYHL---PMPMAAEPLPSSSV--------SGEEARLPPR------------------- 774
E+ +P A P S+ + A+ PP+
Sbjct: 550 EESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSE 609
Query: 775 ---EEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKE 831
E ++ A+ + P A T + L + N VA K
Sbjct: 610 SSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA 669
Query: 832 EKA---------------KPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIE 876
A +P ++++ + + ++EKT GL V AKS G G++
Sbjct: 670 GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKT-----GLAVTVGQAKSVG-KGLQ 723
Query: 877 AFAFGSGLRGAL--------------RLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDE 922
A ++G+L + K +++E SE SE + ++PA+
Sbjct: 724 VKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT 783
Query: 923 DDPEQEKEAG-----EPGRPGT----------------------KPPKRDEERGKTQGKH 955
+ + +A P GT KPP R+ +
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLA-- 841
Query: 956 RKSFALDSEGEEASQESSSEK-DEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSS 1014
R ++ S G+ + + ++ EED EE+ D EE +T ++ +
Sbjct: 842 RGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAET------LAQVKPSGKTHQ 895
Query: 1015 SKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAAL 1074
+ +L + + + + S++ + S SSS S+S + E PAA+
Sbjct: 896 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDS------DGEAPAAV 949
Query: 1075 PSAS--PPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLR 1132
SA PP P +P AG TP Q AS R A +E + S+
Sbjct: 950 TSAQVIKPPLIFVDPNRSP---------AGPAATPAQAQAASTPRKARASESTARSSSSE 1000
Query: 1133 PPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFP 1192
+ P P R + VV P P P+A
Sbjct: 1001 SEDEDVIPATQCLTPGIRTN----------------------VVTMPTAHPRIAPKASMA 1038
Query: 1193 GPASRK 1198
G +S K
Sbjct: 1039 GASSSK 1044
Score = 74.3 bits (181), Expect = 9e-13
Identities = 128/624 (20%), Positives = 206/624 (33%), Gaps = 66/624 (10%)
Query: 829 SKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGAL 888
S+ + KP +++ + D E+ LL K+ A A S +GA
Sbjct: 328 SQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAA 387
Query: 889 RLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPG--RPGTKPPKRDE 946
P K + EE S ++ +E+ P Q K +G+ R + P K
Sbjct: 388 PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESP 447
Query: 947 ERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDG 1006
+G RK+ G A+Q +++E+ EE + EA+ G
Sbjct: 448 RKGAAPAPPRKT------GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1007 EDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEE 1066
+ + +S + G ++ S+ S SSS SS+SS +
Sbjct: 502 KSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVP 561
Query: 1067 EEERPAALPSASPPPREVPVPTPA--PVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
PA S + P +PA P + P V P+ E+S EE
Sbjct: 562 TAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--------EE 613
Query: 1125 SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA 1184
S SA PA +P+ IP K+ T + + + V P
Sbjct: 614 SSDSADSEEA------PAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667
Query: 1185 TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRG-----GRSRAGGRGRL 1239
A P +S G +R D +S +S EE G G++++ G+G
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAE----DSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQ 723
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAV-----EDSEATETSDEAERPRPLLS 1294
+ + L P + G P + V EDSE++E ++E +
Sbjct: 724 VKAASVPVKGSLGQGTAPVL---PGKTG-PTVTQVKAEKQEDSESSEEESDSEEAAASPA 779
Query: 1295 HILLEHNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQ-- 1352
+ A A A + AP + ++ A +P V P+
Sbjct: 780 QVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTV 839
Query: 1353 -------------------QLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRS 1393
Q Q EE EEE + EEE + + G+ R +
Sbjct: 840 LARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA 899
Query: 1394 L---RSHARRRRPPPPPPPPPPRA 1414
L + R+ P PP P A
Sbjct: 900 LAPAKESPRKGAAPTPPGKTGPSA 923
Score = 73.9 bits (180), Expect = 1e-12
Identities = 219/1080 (20%), Positives = 342/1080 (31%), Gaps = 153/1080 (14%)
Query: 192 TVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSS 251
+VP G A +G A ++E SS +T G +V P S T S
Sbjct: 178 SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV--EGKPSV-KPAQVKASSVSTKESP 234
Query: 252 SRQDTPS--SFGQFTPQSSQGT-PYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDA 308
+R+ P+ G TPQ G P R P + + + S P + + + +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKAS 294
Query: 309 FSRRHFSASSASTTASTAIAATTAATASSSASSSSL--------SSSSSSSSSSSSSQFR 360
A+SA + AT A + A +S S SSS SS S +
Sbjct: 295 EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETP 354
Query: 361 SSDANYPAYYESWNRYQRHTSYP----PRRATREEPPG----APFAENTAERFPPSYTSY 412
++ A A S P PR+ PPG A +R S +S
Sbjct: 355 AAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSS- 413
Query: 413 LPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPRPASPARSGSPA 472
S +D + PA P + P+ SP + PR PA +
Sbjct: 414 -----SEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQV 468
Query: 473 PETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGS-EVP 531
+ +S ++ S DS E L ++ L + + S+M +G G+ VP
Sbjct: 469 GKQEEDSRSSSEES--DSDREALAAMNAAQVKPLGKSPQVKPA-STMGMGPLGKGAGPVP 525
Query: 532 SGSGHGPCTPPP----------------------------APA------NFEDVAPTGSG 557
G GP TP APA N PT S
Sbjct: 526 PGKV-GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP 584
Query: 558 EPGATRES-PKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPP 616
G +++ P A P + + E S D PA Q P P
Sbjct: 585 AKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTK-- 642
Query: 617 YLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGM 676
+ P A + P R G P P V +
Sbjct: 643 ---ACPKKTNTTASAKVAPVRV-GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 698
Query: 677 PMSFQMQTQMLTRLHQLRQ-GKGL-IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYA 734
S + +T + + Q + GKGL + A++ P G+ G+ P P + P
Sbjct: 699 SDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG----PTVTQV 754
Query: 735 QGQEGRGAYSREAYHLPMPMAAEPLP-SSSVSGEEARLPPREEAELAEGKTLPTAGTVGR 793
+ ++ + S E AA P +SV +A+ P + T+ G V
Sbjct: 755 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 814
Query: 794 VLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEED---- 849
A Q S ++ + V + S K AA+ Q E+
Sbjct: 815 AAAQAKQRSPSKVKPPVRNPQNSTV----LARGPASVPSVGKAVATAAQAQTGPEEDSGS 870
Query: 850 KEKTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEE 909
E+ E +L SG T I A L A P P + ++ +
Sbjct: 871 SEEESDSEEEAETLAQVKPSGKTHQIRA-----ALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 910 KRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEAS 969
+ + + +E D + E A KPP + ++ + A
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPR 985
Query: 970 QESSSEKDEEDDEEDEEDEDREEAVD------------------------------TTKK 999
+ +SE + EDED A ++K+
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKE 1045
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSS--------SSSSSSSSSS 1051
+ +SDG+ +E ++ S + ++ ++ ++ ++ + SS
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESS 1105
Query: 1052 SSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSP------- 1104
S SS+SSS EE+ E P SA + PTP+ E V E A S
Sbjct: 1106 DDSEDSSDSSSGSEEDGEGPQGAKSA----HTLVGPTPSRTETLVEETAAESSEDDVVAP 1161
Query: 1105 --------VTPLPEQEASPARPAGPTEESPP--SAPLRPPEPPAGPPAPAPRPDERPSSP 1154
+TP S A A P +S P S+ L + P G P+ SP
Sbjct: 1162 SQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSP 1221
Score = 64.7 bits (156), Expect = 7e-10
Identities = 127/579 (21%), Positives = 194/579 (33%), Gaps = 108/579 (18%)
Query: 897 RKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRP------------GTKPPKR 944
RK +E A + K+ R S P E E+E+ E + G P
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 945 DEERGKTQ----GKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKE 1000
+E+ K + GK S + G+ + S + + E A T E
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS--------ANTTLVSE 172
Query: 1001 TEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSES 1060
TE +G +++K + S G+ DS+S+ SSSS + S + +SS S
Sbjct: 173 TE-EEGSVPAFGAAAKPGMV--SAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVS 229
Query: 1061 SSEDEEEEERPA--------------ALPSA----------------SPPPREVPVPTPA 1090
+ E + PA ALP A S E P T +
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRS 289
Query: 1091 PV---EVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRP 1147
V E + R A +P P + A+PA P G PE + +
Sbjct: 290 QVKASEKILQVRAASAPAKGTPGKGATPA-PPGKAGAVASQTKAGKPEEDSESSSEESSD 348
Query: 1148 DERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPP--PATPPQAKFPGPASRKAPRGVER 1205
E + L K KT A PA E P A P GPA KA G
Sbjct: 349 SEEETPAAKALLQAKASGKTSQVGAAS-APAKESPRKGAAPAPPGKTGPAVAKAQAGKRE 407
Query: 1206 TIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPAR 1265
+ + + P + G++ +E G A P R
Sbjct: 408 EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA----------APAPPR 457
Query: 1266 RGLPALPAV----EDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPV 1321
+ PA V ++ ++ +S+E++ R L+ + A VKP +P ++P +
Sbjct: 458 KTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-----NAAQVKPLGKSPQVKPASTM 512
Query: 1322 -PAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSS 1380
P + P P A+ + EE+ E EESSD
Sbjct: 513 GMGPLGKGAGPVPPGKVGPATPSAQV----------------GKWEEDSESSSEESSD-- 554
Query: 1381 SSSDGE-----GALRRRSLRSHARRRRPPPPPPPPPPRA 1414
SSDGE + +SL + + + P PP +A
Sbjct: 555 -SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA 592
Score = 47.8 bits (112), Expect = 9e-05
Identities = 93/466 (19%), Positives = 160/466 (34%), Gaps = 69/466 (14%)
Query: 956 RKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSD---GEDEESD 1012
RK A + +A + S+ + +EE+E E T + + G D S
Sbjct: 61 RKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSS 120
Query: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPA 1072
K + G+ ++ ++ + ++ S S S+ S++ + + EEE
Sbjct: 121 MKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVP 180
Query: 1073 ALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLR 1132
A +A+ P + + + + + S T + E P+ + S S
Sbjct: 181 AFGAAAKPG----MVSAGQADSSSEDTSSSSDETDV---EGKPSVKPAQVKASSVSTKES 233
Query: 1133 PPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFP 1192
P A PAP D P LPP K+ +K P ++
Sbjct: 234 PARKAA--PAPGKVGDVTPQVKGGALPPAKRAKK---------------PEEESESSEEG 276
Query: 1193 GPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVD 1252
+ +AP G ++ E++ + + A +G T + A P
Sbjct: 277 SESEEEAPAGTRSQVKA------------SEKILQVRAASAPAKG--TPGKGATPAPPGK 322
Query: 1253 LAVLADLALTPARRGLPALPAVEDSEAT-ETSDEAERPRPLLSHILLEHNYALAVKPTPP 1311
+A + + G P EDSE++ E S ++E P +L + K +
Sbjct: 323 AGAVA----SQTKAGKPE----EDSESSSEESSDSEEETPAAKALL---QAKASGKTSQV 371
Query: 1312 APALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEE 1371
A P + P A +PA P V A+A + REE + EE +
Sbjct: 372 GAASAPAKESPRKGA---APAPPGKTGPAVAKAQAGK---------REEDSQSSSEESDS 419
Query: 1372 EEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEP 1417
EEE + + S G + S + P P PPR P
Sbjct: 420 EEEAPAQAKPS----GKAPQVRAASAPAKESPRKGAAPAPPRKTGP 461
Score = 47.4 bits (111), Expect = 1e-04
Identities = 117/565 (20%), Positives = 183/565 (32%), Gaps = 109/565 (19%)
Query: 894 KVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGR--PGTKP-PKRDEE--- 947
+VK ++P + SE+SEE S A+ +E +P P TK PK+
Sbjct: 598 QVKAEKPMDNSESSEES----SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS 653
Query: 948 ------RGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVD---TTK 998
R TQ + A G + +++ ED EE + EE T
Sbjct: 654 AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG 713
Query: 999 KETEVSDGEDEESDS--------SSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSS 1050
+ V G ++ S + G + +E S SS S S
Sbjct: 714 QAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEE 773
Query: 1051 SSSSSSSSESSSEDEEEEERPAAL--------------------------PSASPPPREV 1084
+++S + ++S + + + PAA PS PP
Sbjct: 774 AAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRN 833
Query: 1085 PVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESP-------------PSAPL 1131
P + P G V + + P +G +EE PS
Sbjct: 834 PQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKT 893
Query: 1132 RPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTV-SFSAIEVVPAPEPPPATPPQAK 1190
P +PR P+ P P + K S S+ E + PA A+
Sbjct: 894 HQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQ 953
Query: 1191 FPGPA-----SRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEA 1245
P ++P G T + S P + +R S A +E+E+
Sbjct: 954 VIKPPLIFVDPNRSPAGPAATPAQ------AQAASTPRK-ARASESTARSSSSESEDEDV 1006
Query: 1246 EPGTEVDLAVLADLALTPA-RRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYAL 1304
P T+ LTP R + +P A + S S I
Sbjct: 1007 IPATQ---------CLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI-------- 1049
Query: 1305 AVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEE 1364
+ PA + V A +SP ++A + +PK ++QQ +
Sbjct: 1050 SDGKKQEGPATQVDSAVGTLPA--TSPQSTSVQAKGT--NKLRKPKLPEVQQATKA---- 1101
Query: 1365 GEEEGEEEEEESSDSSSSS--DGEG 1387
E ++ E+SSDSSS S DGEG
Sbjct: 1102 --PESSDDSEDSSDSSSGSEEDGEG 1124
Score = 40.0 bits (92), Expect = 0.019
Identities = 57/262 (21%), Positives = 104/262 (39%), Gaps = 60/262 (22%)
Query: 753 PMAAEPLPSSSVSGEEAR--LPPREEAELAEGKTLPTAGTVG------------------ 792
P A + S G+EA P++ + +G P A T+
Sbjct: 1212 PQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNE 1271
Query: 793 -RVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKE 851
+V A +V+ + +++++ RK V + + + WES++ K Q AA+ K+
Sbjct: 1272 AQVQASVVKVLTELLEQE--RKKVVDTTKESSRKGWESRKRKLSGDQPAARTP---RSKK 1326
Query: 852 KTKLKEPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKR 911
K KL A GG + + +G K KR + S +EK+
Sbjct: 1327 KKKLG----------AGEGGEASVSPEKTSTTSKG-------KAKR---DKASGDVKEKK 1366
Query: 912 PRPSTPAEEDEDDPEQE-------KEAGEPGRPGTKPP-------KRDEERGKTQGKHRK 957
+ S ++ +D+PE+E E G+ P +K K+D+E+ + + K +K
Sbjct: 1367 GKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKK 1426
Query: 958 SFALDSEGEEASQESSSEKDEE 979
+ DSE ++ +K E
Sbjct: 1427 ASTKDSESPSQKKKKKKKKTAE 1448
Score = 39.7 bits (91), Expect = 0.025
Identities = 94/465 (20%), Positives = 162/465 (34%), Gaps = 88/465 (18%)
Query: 970 QESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCS----------L 1019
Q++S + EED + ++ V +E S+ E+E ++K + L
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVL 113
Query: 1020 YAD--SDGENDSTSDSESSSSSSSSS-------------SSSSSSSSSSSSSSSESSSED 1064
AD S + + +++E + + +S S S S+ S+++ SE
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 1065 EEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEE 1124
EEE PA +A P + + + + + S T + E P+ +
Sbjct: 174 EEEGSVPAFGAAAKP-----GMVSAGQADSSSEDTSSSSDET---DVEGKPSVKPAQVKA 225
Query: 1125 SPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPA 1184
S S P A PAP D P LPP K+ +K P
Sbjct: 226 SSVSTKESPARKAA--PAPGKVGDVTPQVKGGALPPAKRAKK---------------PEE 268
Query: 1185 TPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEE 1244
++ + +AP G ++ E++ + + A +G T +
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKA------------SEKILQVRAASAPAKG--TPGKG 314
Query: 1245 AEPGTEVDLAVLADLALTPARRGLPALPAVEDSE-ATETSDEAERPRPLLSHILLEHNYA 1303
A P +A + + G P EDSE ++E S ++E P +L
Sbjct: 315 ATPAPPGKAGAVA----SQTKAGKPE----EDSESSSEESSDSEEETPAAKALL---QAK 363
Query: 1304 LAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEE 1363
+ K + A P + P A +PA P V A+A +REE +
Sbjct: 364 ASGKTSQVGAASAPAKESPRKGA---APAPPGKTGPAVAKAQA---------GKREEDSQ 411
Query: 1364 EGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPP 1408
EE + EEE + + S + + R+ P PP
Sbjct: 412 SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPP 456
Score = 36.6 bits (83), Expect = 0.21
Identities = 37/146 (25%), Positives = 60/146 (41%), Gaps = 6/146 (4%)
Query: 1313 PALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPK----PQQLQQQREEGEEEGEEE 1368
P+++P + + + SPA + AP V + K P + ++ E E E EE
Sbjct: 216 PSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEE 275
Query: 1369 GEEEEEESSDSSSSS--DGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTI 1426
G E EEE+ + S E L+ R+ + A+ P PP +A S+ +
Sbjct: 276 GSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 335
Query: 1427 LYDIWNSGLDSEDMSYLRLTYERLLQ 1452
D +S +S D + LLQ
Sbjct: 336 EEDSESSSEESSDSEEETPAAKALLQ 361
Score = 34.3 bits (77), Expect = 1.1
Identities = 40/180 (22%), Positives = 70/180 (38%), Gaps = 32/180 (17%)
Query: 190 PQTVPTGGKALSEKFQG-------SGAATETAESRRRSSSDTAAYPAGTT----AVGTPG 238
P +VP+ GKA++ Q SG++ E ++S + + P+G T A P
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 239 NGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKP 298
+P + P+ G+ P ++Q GS+ DS + TS +
Sbjct: 904 KESP---------RKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQV 954
Query: 299 RRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQ 358
+ + D + AAT A ++S + +S S++ SSSS S+
Sbjct: 955 IKPPLIFVDP------------NRSPAGPAATPAQAQAASTPRKARASESTARSSSSESE 1002
Score = 32.0 bits (71), Expect = 5.3
Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 17/162 (10%)
Query: 898 KEPSEISEASEEKRPRPSTPAEEDEDDPEQEK-EAGEPGRPGTKPPKRDEERGKTQGKHR 956
KE S S +++ PA +++K AGE G P K ++GK +
Sbjct: 1298 KESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT---SKGKAK 1354
Query: 957 KSFALDSEGEEASQESSSEKDEEDDEEDEE-------DEDREEAVDTTKKETEVSDGEDE 1009
+ A E+ + S + +D E +EE E +++ +KKE + SD +
Sbjct: 1355 RDKASGDVKEKKGKGSLGSQGAKD-EPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKK 1413
Query: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSS 1051
+ + K + ST DSES S ++ +
Sbjct: 1414 DKEKKEK-----KKKAKKASTKDSESPSQKKKKKKKKTAEQT 1450
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 83.2 bits (204), Expect = 2e-15
Identities = 120/519 (23%), Positives = 176/519 (33%), Gaps = 102/519 (19%)
Query: 901 SEISEASEEKRPRPSTPAEEDEDDPEQEKEAG----------EPGRPGTKPPK-RDEERG 949
S S +S R P P + P + + P P T PPK R
Sbjct: 358 SSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTP 417
Query: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
+ + RKS S G + + + + E + E+ K +V E E
Sbjct: 418 QQSNRTRKSRVSVSPGRTSGKVTKHKGTE-----------KRESPSPAPKPRKVELSESE 466
Query: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE-- 1067
E D G+ + + + SSS S SSSSS E +
Sbjct: 467 E-----------DKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNG 515
Query: 1068 ----EERPAALPSASPPPREVPVPTP-------APVEVPVPERVAGSPVTPLPEQEASPA 1116
R + SASP PR+ T +P P R + SP P P + +P
Sbjct: 516 EVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPP-PRRRRTPT 574
Query: 1117 RPAGPTEESPPSAPLRPPEPPAGPP-----APAPRPDERPSSPIPLLPPPKKRRKTVSFS 1171
P SPP P PP +P+P P R +SP PPP KRR
Sbjct: 575 PPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASP----PPPPKRR------ 624
Query: 1172 AIEVVPAPEPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRS 1231
+P PPP + P P R +P +R +L H S P +R RS
Sbjct: 625 -----ASPSPPPKR-RVSHSPPPKQRSSP-VTKRRSPSLSSKHRK--GSSPSRSTREARS 675
Query: 1232 RAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRP 1291
+ P T + P RRG + P S + T RP
Sbjct: 676 PQPNKRHSPSPRPRAPQT--------SSSPPPVRRGASSSPQRRQSPSPST-----RPIR 722
Query: 1292 LLSHILLEHNYALAVKPTP---------------PAPALRPPEPVPAPAALFSSPADEVL 1336
+S A P+P P PA + P PAP + S +
Sbjct: 723 RVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKP---PAPPSPVQSQSPSTN 779
Query: 1337 EAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEE 1375
+P V V +A+ P P + + E G+++ ++++++
Sbjct: 780 WSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKK 818
Score = 78.6 bits (192), Expect = 5e-14
Identities = 107/463 (23%), Positives = 166/463 (35%), Gaps = 54/463 (11%)
Query: 982 EEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSS 1041
EE ++ + +E + + KK+ E D D+E SS+ E S S S S
Sbjct: 129 EEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSR---------EKRERSRSPRRRKSRS 179
Query: 1042 SSSSSSSSSSSSSSSSSESSSEDEEEEER-PAALPSASPPPREVPVPTPAPVEVPVPERV 1100
S SS S S S + R P+ P E+P P+ E V E
Sbjct: 180 PSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEAT 239
Query: 1101 AGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPP 1160
+ S + +P+ E P E++ + P R R SP P
Sbjct: 240 STSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPR 299
Query: 1161 PKKRRKTVSFSAIEVVPAPEPPPA----TPPQAKFPGPASRKAPRGVERTIRNLPLDHAS 1216
+ R ++ S+S P+P P+ TPP+ P P R++ V R R+ AS
Sbjct: 300 RRHRSRSRSYSPRRR-PSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRS----SAS 354
Query: 1217 LVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVED 1276
L S S SR+ + + + P + L+ A P RR P+ PA
Sbjct: 355 LSGS----SSSSSSSRSRSPPKKPPKRTSSPPRKTRR--LSPSASPPRRRHRPSPPATPP 408
Query: 1277 SEATETSDEAERPRPLLSHILLEHNYALA-VKPTPPAPALRPPEPVPAPAALFSSPADEV 1335
+ + + R S + + V P P P P + S ++E
Sbjct: 409 PKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEED 468
Query: 1336 LEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLR 1395
+ ++ A++ + + Q +Q ++ + G E+E S +GE RRR
Sbjct: 469 -KGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKR--SHVKNGEVGRRRRHSP 525
Query: 1396 SHA-----------------RRRRPPPPP--------PPPPPR 1413
S + RRR P PPP P PPPR
Sbjct: 526 SRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPR 568
Score = 75.5 bits (184), Expect = 4e-13
Identities = 94/327 (28%), Positives = 120/327 (36%), Gaps = 60/327 (18%)
Query: 340 SSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEPPGAPFAE 399
SS+SLS SSSSSSSS S RS P + TS PPR+ R P +P
Sbjct: 351 SSASLSGSSSSSSSSRS---RSPPKKPP----------KRTSSPPRKTRRLSPSASP--- 394
Query: 400 NTAERFPPSYTSYLPPEPSR-PTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRT 458
R PS + PP+ PT Q P G G + E R
Sbjct: 395 -PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSP----GRTSGKVTKHKGTEKRE 449
Query: 459 SPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKF-SFLASDTEEEEENS 517
SP PA R + ++ A S+ R + + Q+S S +S +E+E
Sbjct: 450 SPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKR 509
Query: 518 SMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPC 577
S V EV H P + + S P ++ G+ + SP
Sbjct: 510 SHV-----KNGEVGRRRRHSP-------------SRSASPSPRKRQKETSPRGRRRRSPS 551
Query: 578 SSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPP----PPPPPPYLASLPLGY-PPHQPAY 632
R SP PAP P ++ P PPP P PPP + P Y PP Q Y
Sbjct: 552 PP-------PTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRY 604
Query: 633 LLPPRPD----GPPPP---EYPPPPPP 652
P P PPPP P PPP
Sbjct: 605 SPSPPPKRRTASPPPPPKRRASPSPPP 631
Score = 72.4 bits (176), Expect = 4e-12
Identities = 115/540 (21%), Positives = 185/540 (34%), Gaps = 77/540 (14%)
Query: 892 SFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKT 951
+F +KE + + +EK E+ + ++EKE+ R ++ P+R + ++
Sbjct: 122 AFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRR--RKSRS 179
Query: 952 QGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEES 1011
R+S + E + S S + E +E+ + + +V + +E+
Sbjct: 180 PSPRRRSSPVRRE-RKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEA 238
Query: 1012 DSSSKCSLY---------ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSS 1062
S+S + E +S + E + S S S S S + S S S +
Sbjct: 239 TSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRP 298
Query: 1063 EDEEEEERPAALPSASPPPREVPVP---TPAPVEVPVPERVAGSPVTPLPEQEASPARPA 1119
+ P P PR P P TP P +P P R S +P+ + S A +
Sbjct: 299 RRRHRSRSRSYSPRRRPSPRRRPSPRRRTP-PRRMPPPPRHRRSR-SPVRRRRRSSASLS 356
Query: 1120 GPTEESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAP 1179
G + S S PP+ P + PR R S P PP++R +
Sbjct: 357 GSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLS---PSASPPRRRHR------------- 400
Query: 1180 EPPPATPPQAKFPGPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRL 1239
PPATPP P +++ R + + P + V R S A + R
Sbjct: 401 PSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPA-PKPRK 459
Query: 1240 TEEEEAEPGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLE 1299
E E+E +A A + +R + S + +S +E RP SH+
Sbjct: 460 VELSESEEDKGGKMAA----ADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHV--- 512
Query: 1300 HNYALAVKPTPPAPALRPPEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQRE 1359
EV + + P P++ Q +
Sbjct: 513 -------------------------------KNGEVGRRRRHSPSRSASPSPRKRQ---K 538
Query: 1360 EGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPP--PPPPPRAYEP 1417
E G + S S RRR+ RRR P PPP P PR Y P
Sbjct: 539 ETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSP 598
Score = 63.2 bits (152), Expect = 2e-09
Identities = 97/453 (21%), Positives = 144/453 (31%), Gaps = 56/453 (12%)
Query: 211 TETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQG 270
T + + R S +A+ P P P ++ + T S +P + G
Sbjct: 378 TSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSG 437
Query: 271 TPYTSRGS--------TPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTT 322
+G+ P + S S K +++ Q RR SS+ +
Sbjct: 438 KVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSG 497
Query: 323 ASTAIAATTAATASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSY 382
+S++ + S S S+S S + P R +R S
Sbjct: 498 SSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPR-----GRRRRSPSP 552
Query: 383 PPRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSR-PTDQDYRPPASEAPPPEPPEPG 441
PP R R P P PP + PP R P+ + Y PP P PP
Sbjct: 553 PPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPP--- 609
Query: 442 GGGGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRS 501
P+R RT+ P P R SP+P HS + + ++RS
Sbjct: 610 ---------PKR---RTASPPPPPKRRASPSPPPKRR----VSHSPPPKQRSSPVTKRRS 653
Query: 502 KFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPT--GSGEP 559
S + + + SS R+ S P+ H P P AP P G+
Sbjct: 654 P-----SLSSKHRKGSSPSRSTREARSPQPN-KRHSPSPRPRAPQTSSSPPPVRRGASSS 707
Query: 560 GATRESPKANGQ---------------NQASPCSSGDDMEISDDDRGGSPPPAPTPPQQP 604
R+SP + + ASP S GSP PA P P
Sbjct: 708 PQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAP 767
Query: 605 PPPPPPPPPPPPYLASLPLGYPPHQPAYLLPPR 637
P P P + ++P+ PPR
Sbjct: 768 PSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPR 800
Score = 49.3 bits (116), Expect = 3e-05
Identities = 138/658 (20%), Positives = 210/658 (31%), Gaps = 114/658 (17%)
Query: 816 ENVAFGAFDQWWESKEEKAKPFQ----NAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGG 871
EN+A G + E K+E+ K Q A + ++EDK+K +E K
Sbjct: 114 ENIA-GIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEE----------KESS 162
Query: 872 TTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEA 931
E S R R PS + + + S + PR T + PE++++
Sbjct: 163 REKRERSR--SPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKT 220
Query: 932 GEPGRPGTKPPKRDEERGKTQGKHRKSFALDS--EGEEASQESSSEKDEEDDEEDEEDED 989
E P K + + + K + E +E S E +S+K++E ++
Sbjct: 221 PELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRS 280
Query: 990 REEAVDTTKKET--EVSDGEDEESDSSSKCSLYADSDGENDS------------------ 1029
R ++ T+ + S S S S S
Sbjct: 281 RSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRR 340
Query: 1030 ----TSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVP 1085
SS+S S SSSSSSSS S S + PSASPP R
Sbjct: 341 SRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRR-- 398
Query: 1086 VPTPAPVEVPVPERVAGSPVTPLPEQ---------EASPARPAGPTEESPPSAPLRPPEP 1136
P+P P P+ + +P P+Q SP R +G + + P
Sbjct: 399 -HRPSPPATPPPK----TRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPS- 452
Query: 1137 PAGPPAPAPRPDERPSS---------PIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPP 1187
PAP PR E S + ++ R+ S+ + + P
Sbjct: 453 ----PAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPK 508
Query: 1188 QAKFP-GPASRKAPRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAE 1246
++ G R+ R+ P K E RG R R+
Sbjct: 509 RSHVKNGEVGRRRRHSPSRSASPSPR------KRQKETSPRGRRRRSPSPPPTRRRRSPS 562
Query: 1247 PGTEVDLAVLADLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAV 1306
P A P RR P P + + + PR I + Y+ +
Sbjct: 563 P------------APPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPI--QRRYSPSP 608
Query: 1307 KP-----TPPAPALRPPEPVPAPAALFS-SPADEVLEAPEVVVAEAEEPKPQQLQQQREE 1360
P +PP P R P P P S SP + +P V + P L + +
Sbjct: 609 PPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSP---VTKRRSP---SLSSKHRK 662
Query: 1361 GEEEGEEEGEEEEEESSDSSSSSDGEGALR--------RRSLRSHARRRRPPPPPPPP 1410
G E + + S S A + RR S +RR+ P P P
Sbjct: 663 GSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP 720
Score = 48.5 bits (114), Expect = 5e-05
Identities = 59/284 (20%), Positives = 95/284 (33%), Gaps = 16/284 (5%)
Query: 889 RLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEER 948
R PS R+ S +R P+ P P + + P R PP +
Sbjct: 548 RSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRR--YSPPIQRRYS 605
Query: 949 GKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGED 1008
K R + AS ++ ++ + TK+ + +
Sbjct: 606 PSPPPKRRTASPPPPPKRRASPSPPPKR-----RVSHSPPPKQRSSPVTKRRSPSLSSKH 660
Query: 1009 EESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEE 1068
+ S S+ + A S N S S + +SSS +SSS S
Sbjct: 661 RKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPST-- 718
Query: 1069 ERPAALPSASPPPREVPV---PTPAPVE-VPVPERVAGSP--VTPLPEQEASPARPAGPT 1122
RP S +P P+++ P+P V V V+GSP P SP + P+
Sbjct: 719 -RPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPS 777
Query: 1123 EESPPSAPLRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRRK 1166
P+ P++ + P P+P D+ KK +K
Sbjct: 778 TNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKK 821
Score = 47.8 bits (112), Expect = 9e-05
Identities = 84/349 (24%), Positives = 114/349 (32%), Gaps = 83/349 (23%)
Query: 349 SSSSSSSSSQFRSSDANYPAYYESWNRYQ-RHTSYPPRRATREEPPGAPFAENTAERFPP 407
S S S S S+ RS P++ R++ R SY PRR +P R PP
Sbjct: 278 SRSRSKSRSRTRSRS---PSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPP 334
Query: 408 SYTSYLPPEPSR---PTDQDYRPPAS-------------EAPPPEPPEPGGGGGGGGPSP 451
PP R P + R AS +PP +PP+ SP
Sbjct: 335 ------PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTS-------SP 381
Query: 452 EREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTE 511
R+ R SP + P R P+P T P +HS + + ++S+ S T
Sbjct: 382 PRKTRRLSPSASPPRRRHRPSPPATPP--PKTRHSPTPQQSN---RTRKSRVSVSPGRTS 436
Query: 512 EEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGAT---RESPKA 568
+ G S P+ P P + G+ A ++ +
Sbjct: 437 GKVTKHK---GTEKRESPSPA--------PKPRKVELSESEEDKGGKMAAADSVQQRRQY 485
Query: 569 NGQNQASPCSSGDDMEISDDDR-------------------GGSPPPAPTPPQQPPPPPP 609
QNQ S SG S+D+R S P+P Q+ P
Sbjct: 486 RRQNQQSSSDSGSSSS-SEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRG 544
Query: 610 ----PPPPPPPYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPP 654
P PPP P PP P R P PP P PPP
Sbjct: 545 RRRRSPSPPPTRRRRSPSPAPP-------PRRRRTPTPPPRRRTPSPPP 586
Score = 46.6 bits (109), Expect = 2e-04
Identities = 110/537 (20%), Positives = 166/537 (30%), Gaps = 91/537 (16%)
Query: 190 PQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSF 249
P+ +P + EK E R RS S + + + T S+ S+
Sbjct: 250 PEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSY 309
Query: 250 SSSRQDTPS---SFGQFTPQSSQGTP-----------YTSRGSTPYSQDSAYSSSTTS-- 293
S R+ +P S + TP P R S S S+ SSS+ S
Sbjct: 310 SPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRS 369
Query: 294 --------TSFKPRRSENSYQDAFS--RRHFSASSASTTASTAIAATTAATASSSASSSS 343
TS PR++ A RRH + A+ T + T + + S S
Sbjct: 370 PPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVS 429
Query: 344 LSSSSSSSSSSSSSQFRSSDANYPA-----------YYESWNRYQRHTSYPPRRATR--- 389
+S +S + ++ PA + + S RR R
Sbjct: 430 VSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQN 489
Query: 390 EEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGG-- 447
++ + +++E P + E R + + P S +P P + G
Sbjct: 490 QQSSSDSGSSSSSEDERPKRSHVKNGEVGRR--RRHSPSRSASPSPRKRQKETSPRGRRR 547
Query: 448 -GPSPEREEVRTSPRPASPAR---SGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKF 503
PSP R SP PA P R + +P P S P + S R ++ + S
Sbjct: 548 RSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPS 607
Query: 504 SFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATR 563
R T S P +PPP P P R
Sbjct: 608 P----------------PPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKR 651
Query: 564 ESPKANGQNQ--ASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPP------------ 609
SP + +++ +SP S + ++ SP P P PQ PPP
Sbjct: 652 RSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRR 711
Query: 610 -PPPPPPPYLASLPLGYPPHQPAYLLPPRP------------DGPPPPEYPPPPPPP 653
P P + + P + P P G P P PP PP
Sbjct: 712 QSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPP 768
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 17/122 (13%)
Query: 1311 PAPALRPPEP-VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEG 1369
PAP + P +P P+ P+ + + ++ + PKP+ + + +E E+ ++
Sbjct: 212 PAPEKKEKTPELPEPSVKVKEPSVQEATSTSDIL---KVPKPEPIPEPKEPSPEKNSKKE 268
Query: 1370 EEEEEESSDSSSSSDGEGALRRRS-------------LRSHARRRRPPPPPPPPPPRAYE 1416
+E+E+ S S S R RS RS++ RRRP P P P R
Sbjct: 269 KEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTP 328
Query: 1417 PR 1418
PR
Sbjct: 329 PR 330
Score = 42.7 bits (99), Expect = 0.003
Identities = 67/283 (23%), Positives = 92/283 (32%), Gaps = 47/283 (16%)
Query: 346 SSSSSSSSSSSSQFRSSDANYPAYYESWNRYQR---HTSYPPRRATREEPPGAPFA-ENT 401
SS S S + R S + P S R +R H+ P R P AP E T
Sbjct: 161 SSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKT 220
Query: 402 AERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPSPEREEVRTSPR 461
E PS P + D P PEP EP E+E+ +T PR
Sbjct: 221 PELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNS---KKEKEKEKTRPR 277
Query: 462 PASPARSGS-PAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMV 520
S ++S S + + + P +H S + S
Sbjct: 278 SRSRSKSRSRTRSRSPSHTRPRRRHRS---------------------------RSRSYS 310
Query: 521 LGARDTGSEVPSGSGH-GPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQNQASPCSS 579
R + PS P PP P + +P R S +G + +S S
Sbjct: 311 PRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRR----RRRSSASLSGSSSSSSSSR 366
Query: 580 GDDMEISDDDRGGSPP-------PAPTPPQQPPPPPPPPPPPP 615
R SPP P+ +PP++ P PP PPP
Sbjct: 367 SRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPP 409
Score = 34.7 bits (78), Expect = 0.82
Identities = 45/206 (21%), Positives = 62/206 (30%), Gaps = 5/206 (2%)
Query: 453 REEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLASDTEE 512
R R R SP R SP S + SR E++ K L + +
Sbjct: 170 RSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVK 229
Query: 513 EEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESPKANGQN 572
+E S + +VP P N + P + S +
Sbjct: 230 VKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTR 289
Query: 573 QASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPP----PPPPPPPPPPYLAS-LPLGYPP 627
SP + R SP P+P ++P P PP PPPP + S P+
Sbjct: 290 SRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRR 349
Query: 628 HQPAYLLPPRPDGPPPPEYPPPPPPP 653
A L PP PP
Sbjct: 350 RSSASLSGSSSSSSSSRSRSPPKKPP 375
>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 82.4 bits (202), Expect = 3e-15
Identities = 45/128 (35%), Positives = 63/128 (49%), Gaps = 1/128 (0%)
Query: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
WGL A I E V EYVG+ I + R K + I Y+ +D D IIDA G
Sbjct: 1075 WGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKG 1134
Query: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
N +RF+NH C PNC T+ ++ +++ I E+T++Y L + K C CG
Sbjct: 1135 NYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCG 1194
Query: 1699 TESCRGSL 1706
+C G L
Sbjct: 1195 ASNCSGFL 1202
Score = 34.7 bits (78), Expect = 0.82
Identities = 38/150 (25%), Positives = 60/150 (40%), Gaps = 11/150 (7%)
Query: 941 PPKRDEERGKTQGKHRK-SFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKK 999
P + +E+ G GK R + + E+A E + K D+ D T K
Sbjct: 511 PVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDT-----ITDK 565
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSS---SSSSSSSSSSSS 1056
S + E+ SS K + + + +S+++SS+ S SSS S+S +
Sbjct: 566 TARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTE 625
Query: 1057 SSESSSEDEEEEERPAALPSASPPPREVPV 1086
+ S S +E E P SA EV V
Sbjct: 626 NEVSDSPGDEPSESP--YESADETQTEVSV 653
>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
[Homo sapiens]
Length = 1365
Score = 82.4 bits (202), Expect = 3e-15
Identities = 45/128 (35%), Positives = 63/128 (49%), Gaps = 1/128 (0%)
Query: 1580 WGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCG 1639
WGL A I E V EYVG+ I + R K + I Y+ +D D IIDA G
Sbjct: 1075 WGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKG 1134
Query: 1640 NLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITYDYKFP-LEDNKIPCLCG 1698
N +RF+NH C PNC T+ ++ +++ I E+T++Y L + K C CG
Sbjct: 1135 NYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCG 1194
Query: 1699 TESCRGSL 1706
+C G L
Sbjct: 1195 ASNCSGFL 1202
Score = 34.7 bits (78), Expect = 0.82
Identities = 38/150 (25%), Positives = 60/150 (40%), Gaps = 11/150 (7%)
Query: 941 PPKRDEERGKTQGKHRK-SFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKK 999
P + +E+ G GK R + + E+A E + K D+ D T K
Sbjct: 511 PVQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDT-----ITDK 565
Query: 1000 ETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSS---SSSSSSSSSSSS 1056
S + E+ SS K + + + +S+++SS+ S SSS S+S +
Sbjct: 566 TARTSSYKAMEAASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTE 625
Query: 1057 SSESSSEDEEEEERPAALPSASPPPREVPV 1086
+ S S +E E P SA EV V
Sbjct: 626 NEVSDSPGDEPSESP--YESADETQTEVSV 653
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.127 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,824,942
Number of Sequences: 37866
Number of extensions: 7165730
Number of successful extensions: 275856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2363
Number of HSP's successfully gapped in prelim test: 3039
Number of HSP's that attempted gapping in prelim test: 53126
Number of HSP's gapped (non-prelim): 108494
length of query: 1707
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1591
effective length of database: 13,855,062
effective search space: 22043403642
effective search space used: 22043403642
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.