Guide to the Human Genome
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Name: EZH2 Sequence: fasta or formatted (751aa) NCBI GI: 21361095
Description:

enhancer of zeste 2 isoform a

Referenced in:

Histones, Related Proteins, and Modifying Enzymes
Stem Cells and Early Development

Other entries for this name:
alt prot [707aa] enhancer of zeste 2 isoform b
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.5         41           3
 C cysteine            4.7         35           1
 D aspartate           7.1         53           7
 E glutamate           8.3         62           4
 F phenylalanine       4.1         31           2
 G glycine             5.1         38           2
 H histidine           2.3         17           1
 I isoleucine          4.9         37           2
 K lysine              8.1         61           3
 L leucine             5.6         42           3
 M methionine          1.7         13           2
 N asparagine          5.3         40           2
 P proline             6.0         45           2
 Q glutamine           4.4         33           2
 R arginine            7.1         53           3
 S serine              6.8         51           4
 T threonine           4.5         34           1
 V valine              4.7         35           2
 W tryptophan          0.9          7           1
 Y tyrosine            3.1         23           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   enhancer of zeste 2 isoform a 
EZH2                  0.923   enhancer of zeste 2 isoform b 
EZH1                  0.618   enhancer of zeste homolog 1 
SETD1B                0.050   SET domain containing 1B 
MLL                   0.048   myeloid/lymphoid or mixed-lineage leukemia protein [...
ASH1L                 0.048   absent, small, or homeotic 1-like 
SUV39H1               0.047   suppressor of variegation 3-9 homolog 1 
SETD2                 0.047   SET domain containing 2 
NSD1                  0.047   nuclear receptor binding SET domain protein 1 isofor...
NSD1                  0.047   nuclear receptor binding SET domain protein 1 isofor...
SETD1A                0.046   SET domain containing 1A 
WHSC1                 0.045   Wolf-Hirschhorn syndrome candidate 1 protein isoform...
WHSC1                 0.045   Wolf-Hirschhorn syndrome candidate 1 protein isoform...
WHSC1                 0.045   Wolf-Hirschhorn syndrome candidate 1 protein isoform...
WHSC1                 0.045   Wolf-Hirschhorn syndrome candidate 1 protein isofor...
WHSC1L1               0.044   WHSC1L1 protein isoform long 
SUV39H2               0.044   suppressor of variegation 3-9 homolog 2 
MLL4                  0.044   myeloid/lymphoid or mixed-lineage leukemia 4 
MLL3                  0.044   myeloid/lymphoid or mixed-lineage leukemia 3 
MLL2                  0.043   myeloid/lymphoid or mixed-lineage leukemia 2 
EHMT2                 0.041   euchromatic histone-lysine N-methyltransferase 2 is...
EHMT2                 0.041   euchromatic histone-lysine N-methyltransferase 2 is...
EHMT1                 0.036   euchromatic histone-lysine N-methyltransferase 1 is...
SETMAR                0.031   SET domain and mariner transposase fusion 
SETD8                 0.025   SET domain-containing 8 
SETDB1                0.015   SET domain, bifurcated 1 isoform 2 
SETDB1                0.015   SET domain, bifurcated 1 isoform 1 
SETDB2                0.014   SET domain, bifurcated 2 isoform b 
SETDB2                0.014   SET domain, bifurcated 2 isoform a 
SETD5                 0.011   SET domain containing 5 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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