Search of human proteins with 54792082

Search of human proteins with 54792082

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54792082 phosphoinositide-3-kinase, catalytic, alpha
polypeptide [Homo sapiens]
         (1068 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept...  2201   0.0  
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo...   743   0.0  
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa...   737   0.0  
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept...   539   e-153
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide...   384   e-106
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid...   375   e-103
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid...   313   7e-85
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi...   164   4e-40
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ...   154   6e-37
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ...   154   6e-37
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa...   114   5e-25
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase...    84   7e-16
gi|4826730 FK506 binding protein 12-rapamycin associated protein...    55   4e-07
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid...    46   2e-04
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated...    46   2e-04
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]     45   3e-04
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]     45   3e-04
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa...    45   3e-04
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide...    45   4e-04
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom...    42   0.003
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad...    42   0.003
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            40   0.015
gi|40353738 c-Mpl binding protein isoform a [Homo sapiens]             33   1.4  
gi|40353736 c-Mpl binding protein isoform c [Homo sapiens]             33   1.4  
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [...    32   2.4  
gi|13699803 WAS protein family, member 3 [Homo sapiens]                32   3.2  
gi|122937335 F-box protein 46 [Homo sapiens]                           32   4.2  
gi|13124883 HsKin17 protein [Homo sapiens]                             31   5.5  
gi|7662162 ALEX2 protein [Homo sapiens]                                31   5.5  
gi|29540562 ALEX2 protein [Homo sapiens]                               31   5.5  

>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
            [Homo sapiens]
          Length = 1068

 Score = 2201 bits (5703), Expect = 0.0
 Identities = 1068/1068 (100%), Positives = 1068/1068 (100%)

Query: 1    MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ 60
            MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
Sbjct: 1    MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ 60

Query: 61   LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA 120
            LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
Sbjct: 61   LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA 120

Query: 121  IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH 180
            IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
Sbjct: 121  IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH 180

Query: 181  IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK 240
            IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
Sbjct: 181  IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK 240

Query: 241  LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD 300
            LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
Sbjct: 241  LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD 300

Query: 301  CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI 360
            CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
Sbjct: 301  CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI 360

Query: 361  YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC 420
            YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
Sbjct: 361  YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC 420

Query: 421  PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF 480
            PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
Sbjct: 421  PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF 480

Query: 481  SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL 540
            SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
Sbjct: 481  SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL 540

Query: 541  SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME 600
            SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
Sbjct: 541  SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME 600

Query: 601  LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660
            LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
Sbjct: 601  LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660

Query: 661  QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK 720
            QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
Sbjct: 661  QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK 720

Query: 721  QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780
            QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
Sbjct: 721  QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780

Query: 781  LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS 840
            LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
Sbjct: 781  LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS 840

Query: 841  IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS 900
            IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
Sbjct: 841  IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS 900

Query: 901  CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF 960
            CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
Sbjct: 901  CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF 960

Query: 961  LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA 1020
            LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
Sbjct: 961  LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA 1020

Query: 1021 YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN 1068
            YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
Sbjct: 1021 YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN 1068


>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
            sapiens]
          Length = 1044

 Score =  743 bits (1919), Expect = 0.0
 Identities = 430/1063 (40%), Positives = 616/1063 (57%), Gaps = 60/1063 (5%)

Query: 20   ILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAER 79
            ++V+ LLP G+ +     R A L TIK  L+  A+  PL  +L    +Y+F  + Q AE+
Sbjct: 20   VVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQ 79

Query: 80   EEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDF 139
            +E  DE RRLCD++ F P L+++   G+R +K++N +I   IG  + EFD + DPEV DF
Sbjct: 80   QELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDF 139

Query: 140  RRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVS 199
            R  +   C+EA   R      +   Y +P  +E S +       +L    ++V     V 
Sbjct: 140  RAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVN----VK 195

Query: 200  PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259
                ++ +T +++   VP  ++A A+RKK       +   +  ++E    Y L+V G  E
Sbjct: 196  FEGSEESFTFQVSTKDVPLALMACALRKK-------ATVFRQPLVEQPEDYTLQVNGRHE 248

Query: 260  YFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMN 319
            Y    YPL Q++YI SC+  G  P+L ++   S+ +         P   +  +   P   
Sbjct: 249  YLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPA 308

Query: 320  GETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVP-C 378
             + S+ SLW +    RI+++  + VN + R   K+ V+ G++HG E LC  V++  V  C
Sbjct: 309  KKPSSVSLWSLEQPFRIELIQGSKVNADERM--KLVVQAGLFHGNEMLCKTVSSSEVSVC 366

Query: 379  SNPRWNEWLNYDIYIPDLPRAARLCLSICSV--------KGRKGAKEEHCPLAWGNINLF 430
            S P W + L +DI I DLPR ARLC ++ +V          +K +K+  CP+AW N+ LF
Sbjct: 367  SEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLF 426

Query: 431  DYTDTLVSGKMALNLWP-VPHGLEDLLNPIGVTGSNPNKETPCLELEF--DWFSSVVKFP 487
            DY D L +G+  L +WP VP    +LLNP G   SNPN ++    L    +     V +P
Sbjct: 427  DYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYP 486

Query: 488  DMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNE---LRENDKEQLKAISTRDPLSEIT 544
             +  I E                      L R +E   + E ++ QL+ I  R    E+ 
Sbjct: 487  ALEKILE----------------------LGRHSECVHVTEEEQLQLREILERRGSGELY 524

Query: 545  EQEKDFLWSHRHYCVT-IPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLD 603
            E EKD +W  RH      PE L +LLL  KWN  ++VAQM  L+  WP +    A+ELLD
Sbjct: 525  EHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLD 584

Query: 604  CNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRI 663
             ++PD  V  FA++ L K LTDD+L QYL+QLVQVLKYE YLD  L +FLL +AL N++I
Sbjct: 585  FSFPDCHVGSFAIKSLRK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKI 643

Query: 664  GHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEK 723
            GHF FWHL+SEMH  +V+ RFGL+LE+YCR    ++K L +Q EA+ KL  L D +K   
Sbjct: 644  GHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSS 703

Query: 724  KDETQKVQMKFLVEQ-MRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLN 782
            + +T K Q K L+   MR+  +++AL    SPL+P+  L  + +E+C  M S  +PLW+ 
Sbjct: 704  Q-KTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIM 762

Query: 783  WENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIG 842
            + N +  S     +  IIFKNGDDLRQDMLTLQ+I++M+ +W+ +GLDLRM PYGCL  G
Sbjct: 763  YSNEEAGSG---GSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTG 819

Query: 843  DCVGLIEVVRNSHTIMQIQC-KGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSC 901
            D  GLIEVV  S TI  IQ  K  +     FN   L  WLK KN GE  D AI+ FT SC
Sbjct: 820  DRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSC 879

Query: 902  AGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL 961
            AGYCVAT++LGIGDRH+ NIM+++ GQLFHIDFGHFL + K KFG  RERVPF+LT DF+
Sbjct: 880  AGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFV 939

Query: 962  IVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAY 1021
             VI +G  +   + +FERF+  C +AY  +R+H  LF++LF++M  +G+PEL    DI Y
Sbjct: 940  HVIQQG--KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQY 997

Query: 1022 IRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
            ++ +LAL KTE+EAL++F  + N+A    W TK++W+ H + +
Sbjct: 998  LKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040


>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
            sapiens]
          Length = 1070

 Score =  737 bits (1902), Expect = 0.0
 Identities = 439/1073 (40%), Positives = 629/1073 (58%), Gaps = 64/1073 (5%)

Query: 20   ILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAER 79
            I V+ LLP G+ + LE  REAT+  IK  L+K+   YP+  LL D  SY+F  V Q A  
Sbjct: 30   IPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVY 89

Query: 80   EEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDF 139
            EE  DETRRLCD+R F P LK++    +  EK L+ +IG  IG  + EFD +KDPEV +F
Sbjct: 90   EELEDETRRLCDVRPFLPVLKLVTRSCDPGEK-LDSKIGVLIGKGLHEFDSLKDPEVNEF 148

Query: 140  RRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVS 199
            RR +    +E +      S        YPP  E  P +P+++ +KL  G++IV +     
Sbjct: 149  RRKMRKFSEEKILSLVGLSWMDWLKQTYPP--EHEPSIPENLEDKLYGGKLIVAVHF--- 203

Query: 200  PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259
              N +  ++ +++ +  P +V   AI+K+        E     V  Y   Y+L+V G  E
Sbjct: 204  -ENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE-----VSPYD--YVLQVSGRVE 255

Query: 260  YFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMN 319
            Y    +PL Q++YIR+C+M   +P+ +L+    +      +   + +   R S+  P   
Sbjct: 256  YVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPL 315

Query: 320  GETSTKSL---WVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRV 376
                T+ +   W  N+  +I ++      +N  +  K++VR G++HG E LC  + +  V
Sbjct: 316  PPKKTRIISHVWENNNPFQIVLVKGN--KLNTEETVKVHVRAGLFHGTELLCKTIVSSEV 373

Query: 377  PCSNPR-WNEWLNYDIYIPDLPRAARLCLSICSV----KGRKGAK--------------E 417
               N   WNE L +DI I DLPR ARLC ++ +V    K +K  K              +
Sbjct: 374  SGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGK 433

Query: 418  EHCPLAWGNINLFDYTDTLVSGKMALNLWP-VPHGLEDLLNPIGVTGSNPNKETP-CLEL 475
             H P+AW N  +FD+   L +G + L+ W   P  LE++LNP+G   +NP  E    L +
Sbjct: 434  VHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHV 493

Query: 476  EFDWFSSVVKF--PDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKA 533
            +F        +  P   +IE+ A  + S  A  S S  G            +     LK 
Sbjct: 494  KFPENKKQPYYYPPFDKIIEKAAEIASSDSANVS-SRGG------------KKFLPVLKE 540

Query: 534  ISTRDPLSEITEQEKDFLWSHRHYCVTI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPP 592
            I  RDPLS++ E E D +W+ R  C  I P+ LPKLLLS+KWN  ++VAQ+  L++ WP 
Sbjct: 541  ILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK 600

Query: 593  IKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRF 652
            + P +A+ELLD NYPD  VR +AV CL + ++D++LSQYL+QLVQVLKYE +LD  L RF
Sbjct: 601  LPPREALELLDFNYPDQYVREYAVGCLRQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRF 659

Query: 653  LLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKL 712
            LL++AL N+RIG F FWHL+SE+H   VS +FG++LE+YCR    ++K L++QVEA+ KL
Sbjct: 660  LLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKL 719

Query: 713  INLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIM 772
              L  ++K       +    + +   +++  + +AL    SPLNP   L  L +E+C+ M
Sbjct: 720  KTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYM 779

Query: 773  SSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLR 832
             S  +PLWL + N     + +     +IFKNGDDLRQDMLTLQ++R+M+ +W+  GLDLR
Sbjct: 780  DSKMKPLWLVYNNKVFGEDSV----GVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLR 835

Query: 833  MLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNKGEIYD 891
            MLPYGCL+ GD  GLIEVV  S TI  IQ     +  A  FN   L  WLK+ N G+  D
Sbjct: 836  MLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLD 895

Query: 892  AAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRER 951
             AI+ FT SCAGYCVA+++LGIGDRH+ NIMVK  GQLFHIDFGH L + K KFG KRER
Sbjct: 896  RAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRER 955

Query: 952  VPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMP 1011
            VPF+LT DF+ VI +G  +   T +F RF++ C  AYL +R+H NLFI LF++ML +G+P
Sbjct: 956  VPFILTYDFIHVIQQG--KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLP 1013

Query: 1012 ELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
            EL S  DI Y++ +LAL K+E+EAL+ F ++ ++A    WTTK++W+ HT+++
Sbjct: 1014 ELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRK 1066


>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
            [Homo sapiens]
          Length = 1102

 Score =  539 bits (1388), Expect = e-153
 Identities = 354/995 (35%), Positives = 532/995 (53%), Gaps = 86/995 (8%)

Query: 107  NREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYV 166
            + E +   R++   IG  V +   V D E++  RR ++      V  RD        +Y 
Sbjct: 144  SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPK------LYA 197

Query: 167  YPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIR 226
              P V S P LP++++ K+    I +VI      +      T+K++ D  P  ++     
Sbjct: 198  MHPWVTSKP-LPEYLWKKIANNCIFIVI------HRSTTSQTIKVSPDDTPGAILQSFFT 250

Query: 227  KKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLM 286
            K  +   L    + +   + +  ++L+VCG DEY + + P+  ++++R C+  G   +++
Sbjct: 251  KMAKKKSL----MDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVV 306

Query: 287  L------MAKESLYSQLPM--DCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKI 338
            L         E    + P+  DC  +  Y  ++ T     +    T SLW  +   R+KI
Sbjct: 307  LDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQL-TIHGKDHESVFTVSLWDCDRKFRVKI 365

Query: 339  LCATYVNVNIRDID-KIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLP 397
                 + V  R+ D  ++V   I HG + LC    + +       WN WL + I I DLP
Sbjct: 366  R-GIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLP 424

Query: 398  RAARLCLSICSVKG----RKGAKEEHCPLAWGNINLFDYTDTLV--------SGKMALNL 445
            + A L L I   K      K + E     + G + L  Y + L+         G+  L++
Sbjct: 425  KGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHM 484

Query: 446  WPVPHGLEDL--LNPIGVTGS-NPNKETPC-LELEFDWFSSVVKFPDMSVIEEHANWSVS 501
            W +    ED    N   +T + NP+KE    + +  D +   +  P      +     V 
Sbjct: 485  WQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVR 544

Query: 502  REAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTI 561
             E                 N+LR+    QL+AI   DPL+ +T ++K+ LW  R+  +  
Sbjct: 545  AEM---------------PNQLRK----QLEAIIATDPLNPLTAEDKELLWHFRYESLKH 585

Query: 562  PEILPKLLLSVKWNSRDEVAQMYCL-----VKDWPPIKPEQAMELLDCNYPDPMVRGFAV 616
            P+  PKL  SVKW  ++ VA+ Y L     V D   +     M+LLDCN+ D  VR  AV
Sbjct: 586  PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAV 645

Query: 617  RCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEM- 675
            + LE  L DD +  YL+QLVQ +K+E Y D+ L RFLLK+ L N+RIGHF FW L+SE+ 
Sbjct: 646  QKLES-LEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA 704

Query: 676  HNKTVSQRFGLLLESYCRACGMYLKH-LNRQVEAMEKLINLT-DI--LKQEKKDETQKV- 730
             ++   QRF ++LE+Y R CG  + H   +QV+ +E L  +T DI  L  EK D + +V 
Sbjct: 705  QSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVI 764

Query: 731  -QMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIM 789
             Q+K  +E ++     ++   F  P +P  + G L +E+C++M+S K+PLWL ++  D  
Sbjct: 765  SQLKQKLENLQNSQLPES---FRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCAD-P 820

Query: 790  SELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIE 849
            + L  +   IIFK+GDDLRQDML LQI+RIME+IW+ + LDL +LPYGC+S GD +G+IE
Sbjct: 821  TALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIE 880

Query: 850  VVRNSHTIMQIQCKG-GLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVA 907
            +V+++ TI +IQ    G  GA  F    L+ WLK+K+  E  + AA++ F  SCAGYCVA
Sbjct: 881  IVKDATTIAKIQQSTVGNTGA--FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVA 938

Query: 908  TFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKG 967
            TF+LGIGDRHN NIM+ + G LFHIDFGH L + K   G  +ERVPFVLT DFL V+   
Sbjct: 939  TFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTS 998

Query: 968  AQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLA 1027
             ++ +    F++FQ++C KAYLA+R H NL I LFSMML +GMP+L S +DI YIR  L 
Sbjct: 999  GKKTSP--HFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALT 1056

Query: 1028 LDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTI 1062
            + K E++A +YF+ Q+      GWT + +W  H +
Sbjct: 1057 VGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV 1091


>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
            [Homo sapiens]
          Length = 1634

 Score =  384 bits (985), Expect = e-106
 Identities = 256/749 (34%), Positives = 382/749 (51%), Gaps = 67/749 (8%)

Query: 335  RIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPR-----WNEWLNY 389
            RI I+ AT         +  Y+   + HGG+ LC  + T+R   S        W++ + +
Sbjct: 640  RIPIIWAT-------SYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICF 692

Query: 390  DIYIPDLPRAARLCLSICSV------KGRKGAKEEHCP--LAWGNINLFDYTDTLVSGKM 441
             + +  LPR   LC ++ ++         +  K+   P  L W    LF++   L  G+ 
Sbjct: 693  PVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRK 752

Query: 442  ALNLWPVPHGLEDLLNPIGVTGSNPNKETP---CLELEFDWFSSVVKFPDMSVIEEHANW 498
             L LWP         NP     S PN   P    L+++F   +  +KF           +
Sbjct: 753  LLGLWPATQE-----NP-SARWSAPNFHQPDSVILQIDFPTSAFDIKFTS----PPGDKF 802

Query: 499  SVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYC 558
            S   E G                 LRE D+ +LK I  ++ L  +T+ +K  LW  R+YC
Sbjct: 803  SPRYEFG----------------SLREEDQRKLKDIMQKESLYWLTDADKKRLWEKRYYC 846

Query: 559  VTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRC 618
             +    LP +L S        +  +Y L+K W  +  + A+ LL   +PD  VR  AV+ 
Sbjct: 847  HSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQW 906

Query: 619  LEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNK 678
            +   L+D +L  YL QLVQ LKYE YLD+ LVRFLLK+A+++ R+ H+FFW LK  + + 
Sbjct: 907  IGS-LSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDS 965

Query: 679  TVSQRFGLLLESYCRACGMYLK-HLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVE 737
              S R+  LL +    CG  L+   NRQ      L+N    L Q+ ++     +   L  
Sbjct: 966  QFSIRYQYLLAALLCCCGKGLREEFNRQC----WLVNALAKLAQQVREAAPSARQGILRT 1021

Query: 738  QMRRPDFMDALQGFLS-PLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQN 796
             +       AL G    PL+P+  +  +   +C   +S   PL L+++N D + E    N
Sbjct: 1022 GLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDPLGE----N 1077

Query: 797  NEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHT 856
              +IFK GDDLRQDMLTLQ+IRIM  IW  +GLD+RM+ + C S G   G++E++ N+ T
Sbjct: 1078 IRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAET 1137

Query: 857  IMQIQCKGGLKGALQFNSHTLHQWLKDKNKGE-IYDAAIDLFTRSCAGYCVATFILGIGD 915
            + +IQ + G+ G+  F    L  WL+  N GE  Y+ A++ F  SCAG CVAT++LGI D
Sbjct: 1138 LRKIQVEHGVTGS--FKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICD 1195

Query: 916  RHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR 975
            RHN NIM+K  G +FHIDFG FL H +     KR+R PFV T D   VI+ G +  ++  
Sbjct: 1196 RHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSR-- 1253

Query: 976  EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEA 1035
             F  F ++C +AY  IR+H +LF+NL  +ML  G+PEL   +D+ Y+   L    TE  A
Sbjct: 1254 -FHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANA 1312

Query: 1036 LEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
              YF + + ++  G   TK+++  H + Q
Sbjct: 1313 TTYFTR-LIESSLGSVATKLNFFIHNLAQ 1340



 Score = 34.3 bits (77), Expect = 0.64
 Identities = 16/50 (32%), Positives = 27/50 (54%)

Query: 248 GKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQL 297
           G ++LK CG +E+   K+ L  ++YI+ C        L LM ++ + S L
Sbjct: 422 GDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDL 471


>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
            [Homo sapiens]
          Length = 1686

 Score =  375 bits (962), Expect = e-103
 Identities = 257/765 (33%), Positives = 388/765 (50%), Gaps = 67/765 (8%)

Query: 323  STKSLWVINSALRIKILCATYVNVN-IRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNP 381
            S K  W     L+  I  A  ++ N + + +K Y+   + H G+ L   + +++V     
Sbjct: 675  SVKEAWTTTEQLQFTIFAAHGISSNWVSNYEKYYLICSLSHNGKDLFKPIQSKKVGTYKN 734

Query: 382  -----RWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGA------KEEHCPLAWGNINL- 429
                 +W+E + + I I  LP  + L L++  +  +         K+   P A G ++L 
Sbjct: 735  FFYLIKWDELIIFPIQISQLPLESVLHLTLFGILNQSSGSSPDSNKQRKGPEALGKVSLP 794

Query: 430  -FDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDW--FSSVVKF 486
             FD+   L  G   L LW   H       P  VT      E   L+++F    F  +   
Sbjct: 795  LFDFKRFLTCGTKLLYLWTSSHTNSV---PGTVTKKGYVMERIVLQVDFPSPAFDIIYTT 851

Query: 487  P--DMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELREND-KEQLKAISTRDPLSEI 543
            P  D S+I++H                        + E  END K +L  I  +D    +
Sbjct: 852  PQVDRSIIQQH------------------------NLETLENDIKGKLLDILHKDSSLGL 887

Query: 544  TEQEKDFLWSHRHYCVTIPEILPKLLLSV---KWNSRDEVAQMYCLVKDWPPIKPEQAME 600
            ++++K FLW  R+YC   P  LPK+L S    KW +   +A+ Y L+  WP + P  A+E
Sbjct: 888  SKEDKAFLWEKRYYCFKHPNCLPKILASAPNWKWVN---LAKTYSLLHQWPALYPLIALE 944

Query: 601  LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660
            LLD  + D  VR  AV  +E  ++DD+L+  L Q VQ LKYE YL++ LV+FLL +AL N
Sbjct: 945  LLDSKFADQEVRSLAVTWIEA-ISDDELTDLLPQFVQALKYEIYLNSSLVQFLLSRALGN 1003

Query: 661  QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK 720
             +I H  +W LK  +H+   S R+  +L +     G   K L  ++    KL+ L   + 
Sbjct: 1004 IQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGG---KRLREELLKQTKLVQLLGGVA 1060

Query: 721  QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780
            ++ +  +   +   L   M R            PL P+     L ++ C   SS   PL 
Sbjct: 1061 EKVRQASGSARQVVLQRSMERVQSFFQKNKCRLPLKPSLVAKELNIKSCSFFSSNAVPLK 1120

Query: 781  LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS 840
            +   N D M E +     ++FK G+DLRQDML LQ+I+IM+ IW  +GLDLRM+ + CLS
Sbjct: 1121 VTMVNADPMGEEI----NVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLS 1176

Query: 841  IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTR 899
             G   G++E+V  S T+ +IQ + G+ G+  F    L +WL+  N  E  Y+ A + F  
Sbjct: 1177 TGRDRGMVELVPASDTLRKIQVEYGVTGS--FKDKPLAEWLRKYNPSEEEYEKASENFIY 1234

Query: 900  SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD 959
            SCAG CVAT++LGI DRHN NIM++  G +FHIDFG FL H +    +KR+R PFVLT D
Sbjct: 1235 SCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSD 1294

Query: 960  FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI 1019
               VI+ G +    T  F+ F ++C +AY  IR+  NLF+NL S+M+ SG+PEL S  D+
Sbjct: 1295 MAYVINGGEK---PTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDL 1351

Query: 1020 AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
             Y+R  L    T+ EA  +F + + ++  G   TK ++  H + Q
Sbjct: 1352 KYVRDALQPQTTDAEATIFFTR-LIESSLGSIATKFNFFIHNLAQ 1395



 Score = 30.8 bits (68), Expect = 7.1
 Identities = 11/29 (37%), Positives = 19/29 (65%)

Query: 248 GKYILKVCGCDEYFLEKYPLSQYKYIRSC 276
           G Y+LKVCG +E     + L  +++I++C
Sbjct: 468 GSYVLKVCGQEEVLQNNHCLGSHEHIQNC 496


>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
            [Homo sapiens]
          Length = 1445

 Score =  313 bits (801), Expect = 7e-85
 Identities = 231/756 (30%), Positives = 375/756 (49%), Gaps = 53/756 (7%)

Query: 317  YMNGETSTKSLWV-INSALRIKI--LCATYVNVNIRDIDKIYVR--TGIYHGGEPLCDNV 371
            Y + ETS K L   + + L   I  L   Y N    D   + V   T   + G P   + 
Sbjct: 468  YQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPVNVPRCTSYLNPGLPSHLSF 527

Query: 372  NTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFD 431
                       W   +N+ + I  LPR + L + +  +     A      LAW  + LF 
Sbjct: 528  TVYAAHNIPETWVHRINFPLEIKSLPRESMLTVKLFGIAC---ATNNANLLAWTCLPLFP 584

Query: 432  YTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSV 491
               +++ G M  ++        +++ P     S P+  T  L+++F         PD   
Sbjct: 585  KEKSIL-GSMLFSMTLQSEPPVEMITPGVWDVSQPSPVT--LQIDFPATGWEYMKPDSE- 640

Query: 492  IEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFL 551
                                   NR   +  L+E  K   +    + PL  ++E++K +L
Sbjct: 641  ----------------------ENRSNLEEPLKECIKHIARLSQKQTPLL-LSEEKKRYL 677

Query: 552  WSHRHYCVTIPEILPKLLLSVK-WNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPM 610
            W +R YC      LP +L S   W+ R  V++M+ +++ W   +P +A+ LL  ++PD  
Sbjct: 678  WFYRFYCNNENCSLPLVLGSAPGWDERT-VSEMHTILRRWTFSQPLEALGLLTSSFPDQE 736

Query: 611  VRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWH 670
            +R  AV+ L+  L D+ L +YL QLVQ +K+E  L++ LV+ LL ++L + ++ H  +W 
Sbjct: 737  IRKVAVQQLDNLLNDELL-EYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWL 795

Query: 671  LKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKV 730
            LK+  +       +  LL +     G   K LN +    +KLI +   + +  K  +   
Sbjct: 796  LKNAENEAYFKSWYQKLLAALQFCAG---KALNDEFSKEQKLIKILGDIGERVKSASDHQ 852

Query: 731  QMKFLVEQMRR-PDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIM 789
            + + L +++ R  +F   +     PLNPA  +  +  + C   +S   PL + + N + M
Sbjct: 853  RQEVLKKEIGRLEEFFQDVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANPM 912

Query: 790  SELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIE 849
             +    N  IIFK GDDLRQDML LQ+I++M+NIW  +GLD++M+ Y CLS G   GL++
Sbjct: 913  GK----NISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQ 968

Query: 850  VVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEI-YDAAIDLFTRSCAGYCVAT 908
            +V ++ T+ +I    GL G L+ N  T+ +W    N  +  Y+ A+  F  SCAG+CV T
Sbjct: 969  MVPDAVTLAKIHRHSGLIGPLKEN--TIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVT 1026

Query: 909  FILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGA 968
            FILG+ DRHN NIM+   G +FHIDFG FL H +   G KR+R PF+ T +    I++G 
Sbjct: 1027 FILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086

Query: 969  QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLAL 1028
            +     + F+ F E+C +AY  IR+H+ L +NL  MML +G+PEL    D+ Y+   L  
Sbjct: 1087 K---NPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRP 1143

Query: 1029 DKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064
              T+ EA  +F K++ ++    +  K++ + HT+ Q
Sbjct: 1144 QDTDLEATSHFTKKIKESLE-CFPVKLNNLIHTLAQ 1178


>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
          Length = 887

 Score =  164 bits (415), Expect = 4e-40
 Identities = 111/438 (25%), Positives = 219/438 (50%), Gaps = 41/438 (9%)

Query: 645  LDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHL-- 702
            L+  L  FL+ +A  N  + ++ +W++  E  ++   QR     E Y      + + L  
Sbjct: 471  LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530

Query: 703  -NRQVEAM-----------EKLINLTDILKQEKKDETQKVQ-MKFLVEQMRRPDFMDALQ 749
             ++ V  M           ++L++L   +++E  +  +K + ++ L+    + +  D ++
Sbjct: 531  GDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSD-VE 589

Query: 750  GFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQ 809
                PL P  ++  +  E   +  SA  P  L ++  D           +IFK+GDDLRQ
Sbjct: 590  LIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED------GGKYPVIFKHGDDLRQ 643

Query: 810  DMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGA 869
            D L LQII +M+ + + + LDL++ PY  L+     G ++ +++      +  +G ++  
Sbjct: 644  DQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNF 703

Query: 870  LQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQL 929
             +  + +      +     I    +D + +SCAGYCV T+ILG+GDRH  N+++   G+L
Sbjct: 704  FRKYAPS------ENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKL 757

Query: 930  FHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYL 989
            FHIDFG+ L    K         P  L ++  +V   G    T++ +++ F++ CY A+L
Sbjct: 758  FHIDFGYILGRDPKPL-----PPPMKLNKE--MVEGMGG---TQSEQYQEFRKQCYTAFL 807

Query: 990  AIRQHANLFINLFSMMLGSGMPELQSFDD--IAYIRKTLALDKTEQEALEYFMKQMNDAH 1047
             +R+++NL +NLFS+M+ + +P++    D  +  ++    LD +++EA+ Y    ++++ 
Sbjct: 808  HLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESV 867

Query: 1048 HGGWTTKMDWIFHTIKQH 1065
            H  +   ++ I H   Q+
Sbjct: 868  HALFAAVVEQI-HKFAQY 884



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 47/129 (36%), Positives = 72/129 (55%), Gaps = 3/129 (2%)

Query: 520 DNELREN--DKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSR 577
           D++L+ N   ++QL  I +  P  ++T +E+D +W  R+Y     + L K L  V W+  
Sbjct: 283 DHDLKPNAATRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLP 342

Query: 578 DEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQ 637
            E  Q   L+  W P+  E ++ELL  +Y +P VR +AV  L +   D+ L  YL+QLVQ
Sbjct: 343 QEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARL-RQADDEDLLMYLLQLVQ 401

Query: 638 VLKYEQYLD 646
            LKYE + D
Sbjct: 402 ALKYENFDD 410



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 31/95 (32%), Positives = 43/95 (45%), Gaps = 5/95 (5%)

Query: 354 IYVRTGIYHGGEPLCDNVNTQRVPCSNP-RWNEWLNYDIYIPDLPRAARLCLSICSVKGR 412
           +YV   ++  G+PL   V T     S    WNEWL   +  PDLPR A++ L+I  V G 
Sbjct: 57  LYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGP 116

Query: 413 KGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWP 447
             A     P+    ++LF        G   L +WP
Sbjct: 117 GKA----VPVGGTTVSLFGKYGMFRQGMHDLKVWP 147


>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
            sapiens]
          Length = 854

 Score =  154 bits (388), Expect = 6e-37
 Identities = 140/517 (27%), Positives = 225/517 (43%), Gaps = 62/517 (11%)

Query: 561  IPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPD-PMVRGFAVRCL 619
            +PE +  L   V W++ D  A     V  W P  P   +      YP  P+   + V+ L
Sbjct: 338  VPEAIKFL---VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 394

Query: 620  EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKS------ 673
              +   D +  Y+ Q+VQ L+Y++     +  ++L  A  +Q + H F W++K+      
Sbjct: 395  RSF-PPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 451

Query: 674  EMHNKT--VSQRFGLLLESYCRACGMYLKHL-NRQVEAMEKLINLTDILKQEKK-DETQK 729
            E H K   +      L+E    +     K    R+ +   K+ N++ I+K   K DE +K
Sbjct: 452  EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 511

Query: 730  VQMKFLVEQMRRPDFMDALQGFLSPLNP--------------------AHQLGNLRLEEC 769
              +  L E   +P       G   P NP                    A  L   +++ C
Sbjct: 512  ACLSALSEVKVQP-------GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRC 564

Query: 770  RIMSSAKRPLWLNWENPDIMSELLFQNNEI-----IFKNGDDLRQDMLTLQIIRIMENIW 824
             +    K  L    ++ D  S       +I     IFK GDD RQDML LQII + +NI+
Sbjct: 565  GVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIF 624

Query: 825  QNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDK 884
            Q  GLDL + PY  ++     G+IE + +  +  Q+    G +       +   Q+  + 
Sbjct: 625  QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL----GRQTDFGMYDYFTRQYGDES 680

Query: 885  NKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKK 944
                 +  A   F RS A Y +  F+L I DRHN NIM+   G + HIDFG   +     
Sbjct: 681  TLA--FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSP-- 736

Query: 945  FGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSM 1004
             G      P +   D +++I  G  E T    F+ F EMC + YLA+R + +  ++L ++
Sbjct: 737  -GGNLGWEPDIKLTDEMVMIMGGKMEAT---PFKWFMEMCVRGYLAVRPYMDAVVSLVTL 792

Query: 1005 MLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMK 1041
            ML +G+P  +    I  ++   + + TE+EA  + MK
Sbjct: 793  MLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIMK 828


>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
            [Homo sapiens]
          Length = 2044

 Score =  154 bits (388), Expect = 6e-37
 Identities = 140/517 (27%), Positives = 225/517 (43%), Gaps = 62/517 (11%)

Query: 561  IPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPD-PMVRGFAVRCL 619
            +PE +  L   V W++ D  A     V  W P  P   +      YP  P+   + V+ L
Sbjct: 1528 VPEAIKFL---VTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 1584

Query: 620  EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKS------ 673
              +   D +  Y+ Q+VQ L+Y++     +  ++L  A  +Q + H F W++K+      
Sbjct: 1585 RSF-PPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDE 1641

Query: 674  EMHNKT--VSQRFGLLLESYCRACGMYLKHL-NRQVEAMEKLINLTDILKQEKK-DETQK 729
            E H K   +      L+E    +     K    R+ +   K+ N++ I+K   K DE +K
Sbjct: 1642 EGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK 1701

Query: 730  VQMKFLVEQMRRPDFMDALQGFLSPLNP--------------------AHQLGNLRLEEC 769
              +  L E   +P       G   P NP                    A  L   +++ C
Sbjct: 1702 ACLSALSEVKVQP-------GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRC 1754

Query: 770  RIMSSAKRPLWLNWENPDIMSELLFQNNEI-----IFKNGDDLRQDMLTLQIIRIMENIW 824
             +    K  L    ++ D  S       +I     IFK GDD RQDML LQII + +NI+
Sbjct: 1755 GVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIF 1814

Query: 825  QNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDK 884
            Q  GLDL + PY  ++     G+IE + +  +  Q+    G +       +   Q+  + 
Sbjct: 1815 QLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL----GRQTDFGMYDYFTRQYGDES 1870

Query: 885  NKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKK 944
                 +  A   F RS A Y +  F+L I DRHN NIM+   G + HIDFG   +     
Sbjct: 1871 TLA--FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSP-- 1926

Query: 945  FGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSM 1004
             G      P +   D +++I  G  E T    F+ F EMC + YLA+R + +  ++L ++
Sbjct: 1927 -GGNLGWEPDIKLTDEMVMIMGGKMEAT---PFKWFMEMCVRGYLAVRPYMDAVVSLVTL 1982

Query: 1005 MLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMK 1041
            ML +G+P  +    I  ++   + + TE+EA  + MK
Sbjct: 1983 MLDTGLPCFRG-QTIKLLKHRFSPNMTEREAANFIMK 2018


>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
            sapiens]
          Length = 828

 Score =  114 bits (285), Expect = 5e-25
 Identities = 76/260 (29%), Positives = 134/260 (51%), Gaps = 19/260 (7%)

Query: 799  IIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIM 858
            +I K GDDLRQ++L  Q+++ +++IW+ + + L + PY  L I    G+IE V N+ +I 
Sbjct: 573  VIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIH 632

Query: 859  QIQCKGGLKGALQFNSHTLHQWLKDKNK--GEIYDAAIDLFTRSCAGYCVATFILGIGDR 916
            Q++ +  L          L  +L++      E + +A   F +SCAGYC+  ++L + DR
Sbjct: 633  QVKKQSQLS--------LLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDR 684

Query: 917  HNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTRE 976
            HN NI++  +G + HIDFG  L    +  G+  E   F LT +F+ V+     +      
Sbjct: 685  HNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVMGGLDGDM----- 737

Query: 977  FERFQEMCYKAYLAIRQHANLFINLFSMM-LGSGMPELQSFDDIAYIRKTLALDKTEQEA 1035
            F  ++ +  +  +A R+H +  + +  +M  GS +P       I  +++   +  TE E 
Sbjct: 738  FNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTE-EQ 796

Query: 1036 LEYFMKQMNDAHHGGWTTKM 1055
            L+  ++QM D      TTK+
Sbjct: 797  LQLLVEQMVDGSMRSITTKL 816


>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
           type 3 alpha [Homo sapiens]
          Length = 286

 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 60/187 (32%), Positives = 88/187 (47%), Gaps = 11/187 (5%)

Query: 758 AHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEI-----IFKNGDDLRQDML 812
           A  L   +++ C +    K  L    ++ D  S       +I     IFK GDD RQDML
Sbjct: 7   APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKLGDDCRQDML 66

Query: 813 TLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQF 872
            LQII + +NI+Q  GLDL + PY  ++     G+IE + +  +  Q+    G +     
Sbjct: 67  ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQL----GRQTDFGM 122

Query: 873 NSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHI 932
             +   Q+  +      +  A   F RS A Y +  F+L I DRHN NIM+   G + HI
Sbjct: 123 YDYFTRQYGDESTLA--FQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHI 180

Query: 933 DFGHFLD 939
           DFG   +
Sbjct: 181 DFGFMFE 187


>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
            [Homo sapiens]
          Length = 2549

 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 69/277 (24%), Positives = 119/277 (42%), Gaps = 61/277 (22%)

Query: 726  ETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWEN 785
            E Q V  K L+ +    D   A+ G   P  P  ++ ++     ++++S +RP  L    
Sbjct: 2122 ELQYVSPKLLMCR----DLELAVPGTYDPNQPIIRIQSIA-PSLQVITSKQRPRKLTLMG 2176

Query: 786  PDIMSELLFQNNEIIF--KNGDDLRQDMLTLQIIRIMENIWQNQGLDLR----MLPYGCL 839
             +         +E +F  K  +DLRQD   +Q+  ++  +  N    LR    +  Y  +
Sbjct: 2177 SN--------GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVI 2228

Query: 840  SIGDCVGLIEVVRNSHTI--------------MQIQCKGGLKGALQFNSHTLHQ------ 879
             +    GLI  V +  T+              + I+ +  L+ A  ++  TL Q      
Sbjct: 2229 PLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFE 2288

Query: 880  ---------------WLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMV- 923
                           WLK  +    +D   + +TRS A   +  +ILG+GDRH SN+M+ 
Sbjct: 2289 HAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN-YTRSLAVMSMVGYILGLGDRHPSNLMLD 2347

Query: 924  KDDGQLFHIDFGHFLD--HKKKKFGYKRERVPFVLTQ 958
            +  G++ HIDFG   +    ++KF    E++PF LT+
Sbjct: 2348 RLSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTR 2381


>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
            isoform 2 [Homo sapiens]
          Length = 4097

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 57/221 (25%), Positives = 90/221 (40%), Gaps = 33/221 (14%)

Query: 767  EECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIW-- 824
            E   +M+S +RP  +     D       + +  + K G+DLRQD    Q+ ++M  I   
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHDE------REHPFLVKGGEDLRQDQRVEQLFQVMNGILAQ 3777

Query: 825  ----QNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGL-----KGALQFNSH 875
                  + L LR      ++  D        ++  T M  +   G      KGA +  + 
Sbjct: 3778 DSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETV 3837

Query: 876  TLHQWLKDKNKGEIYDAAI--------------DLFTRSCAGYCVATFILGIGDRHNSNI 921
            T  +  + K   ++   A                 F  S A  C++ +ILGIGDRH +N 
Sbjct: 3838 TSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNF 3897

Query: 922  MV-KDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL 961
            MV  + G +  IDFGH       +F    E +PF LT+ F+
Sbjct: 3898 MVAMETGGVIGIDFGHAFG-SATQFLPVPELMPFRLTRQFI 3937


>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
            catalytic polypeptide [Homo sapiens]
          Length = 4096

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 57/221 (25%), Positives = 90/221 (40%), Gaps = 33/221 (14%)

Query: 767  EECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIW-- 824
            E   +M+S +RP  +     D       + +  + K G+DLRQD    Q+ ++M  I   
Sbjct: 3723 ERVTVMASLRRPKRIIIRGHDE------REHPFLVKGGEDLRQDQRVEQLFQVMNGILAQ 3776

Query: 825  ----QNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGL-----KGALQFNSH 875
                  + L LR      ++  D        ++  T M  +   G      KGA +  + 
Sbjct: 3777 DSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETV 3836

Query: 876  TLHQWLKDKNKGEIYDAAI--------------DLFTRSCAGYCVATFILGIGDRHNSNI 921
            T  +  + K   ++   A                 F  S A  C++ +ILGIGDRH +N 
Sbjct: 3837 TSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNF 3896

Query: 922  MV-KDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL 961
            MV  + G +  IDFGH       +F    E +PF LT+ F+
Sbjct: 3897 MVAMETGGVIGIDFGHAFG-SATQFLPVPELMPFRLTRQFI 3936


>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
          Length = 1708

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 3/66 (4%)

Query: 897  FTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
            +TRS A   +  +ILG+GDRH  NI++ +   +L HID G  +  ++ K     E VPF 
Sbjct: 1504 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--VAFEQGKILPTPETVPFR 1561

Query: 956  LTQDFL 961
            LT+D +
Sbjct: 1562 LTRDIV 1567


>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
          Length = 3056

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 3/66 (4%)

Query: 897  FTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
            +TRS A   +  +ILG+GDRH  NI++ +   +L HID G  +  ++ K     E VPF 
Sbjct: 2852 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--VAFEQGKILPTPETVPFR 2909

Query: 956  LTQDFL 961
            LT+D +
Sbjct: 2910 LTRDIV 2915


>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
            [Homo sapiens]
          Length = 2934

 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 26/66 (39%), Positives = 39/66 (59%), Gaps = 3/66 (4%)

Query: 897  FTRSCAGYCVATFILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
            +TRS A   +  +ILG+GDRH  NI++ +   +L HID G  +  ++ K     E VPF 
Sbjct: 2730 YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--VAFEQGKILPTPETVPFR 2787

Query: 956  LTQDFL 961
            LT+D +
Sbjct: 2788 LTRDIV 2793


>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
            isoform 1 [Homo sapiens]
          Length = 4128

 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 28/66 (42%), Positives = 38/66 (57%), Gaps = 2/66 (3%)

Query: 897  FTRSCAGYCVATFILGIGDRHNSNIMV-KDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
            F  S A  C++ +ILGIGDRH +N MV  + G +  IDFGH       +F    E +PF 
Sbjct: 3904 FASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFG-SATQFLPVPELMPFR 3962

Query: 956  LTQDFL 961
            LT+ F+
Sbjct: 3963 LTRQFI 3968



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 24/98 (24%), Positives = 44/98 (44%), Gaps = 10/98 (10%)

Query: 767  EECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQN 826
            E   +M+S +RP  +     D       + +  + K G+DLRQD    Q+ ++M  I   
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHDE------REHPFLVKGGEDLRQDQRVEQLFQVMNGILAQ 3777

Query: 827  QGL----DLRMLPYGCLSIGDCVGLIEVVRNSHTIMQI 860
                    L++  Y  + +   +GLIE + N+ T+  +
Sbjct: 3778 DSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDL 3815


>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
            sapiens]
          Length = 2644

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 38/196 (19%)

Query: 802  KNGDDLRQDMLTLQ----IIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTI 857
            K  DDLR+D   ++    I + +    +++  +L +  Y  + + D  G+IE V N+  +
Sbjct: 2327 KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 2386

Query: 858  MQI------------------QCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFT- 898
              I                  QC      AL        ++L  ++    ++  +  F  
Sbjct: 2387 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 2446

Query: 899  -----RSCAGYCVAT-------FILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKF 945
                  S + YC +T       +ILG+GDRH  NI+     G+  H+DF + L +K + F
Sbjct: 2447 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 2505

Query: 946  GYKRERVPFVLTQDFL 961
                E VPF LT + +
Sbjct: 2506 EVP-EIVPFRLTHNMV 2520


>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
           related protein, partial [Homo sapiens]
          Length = 386

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 38/196 (19%)

Query: 802 KNGDDLRQDMLTLQ----IIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTI 857
           K  DDLR+D   ++    I + +    +++  +L +  Y  + + D  G+IE V N+  +
Sbjct: 69  KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 128

Query: 858 MQI------------------QCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFT- 898
             I                  QC      AL        ++L  ++    ++  +  F  
Sbjct: 129 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 188

Query: 899 -----RSCAGYCVAT-------FILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKF 945
                 S + YC +T       +ILG+GDRH  NI+     G+  H+DF + L +K + F
Sbjct: 189 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 247

Query: 946 GYKRERVPFVLTQDFL 961
               E VPF LT + +
Sbjct: 248 EVP-EIVPFRLTHNMV 262


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 39.7 bits (91), Expect = 0.015
 Identities = 22/64 (34%), Positives = 38/64 (59%), Gaps = 3/64 (4%)

Query: 897  FTRSCAGYCVATFILGIGDRHNSNIMV-KDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV 955
            + RS A   +  +I+G+GDRH  N+++    G++ HID+   +  +K K     E+VPF 
Sbjct: 2317 YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYN--VCFEKGKSLRVPEKVPFR 2374

Query: 956  LTQD 959
            +TQ+
Sbjct: 2375 MTQN 2378


>gi|40353738 c-Mpl binding protein isoform a [Homo sapiens]
          Length = 724

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 31/105 (29%), Positives = 47/105 (44%), Gaps = 9/105 (8%)

Query: 447 PVPHGLEDLLNPIGVT-GSNPN-----KETPCLELEFDWFSSVVKFPDMSVIEEHANWSV 500
           PV HG E   + I  T G++P       E  C E E  + SS     + + IEE  +  +
Sbjct: 34  PVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDGMI 93

Query: 501 SREAGFSYSH---AGLSNRLARDNELRENDKEQLKAISTRDPLSE 542
                 SY     +G SN      +L+E  K+QL+   +R+ LS+
Sbjct: 94  LGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSK 138


>gi|40353736 c-Mpl binding protein isoform c [Homo sapiens]
          Length = 653

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 31/105 (29%), Positives = 47/105 (44%), Gaps = 9/105 (8%)

Query: 447 PVPHGLEDLLNPIGVT-GSNPN-----KETPCLELEFDWFSSVVKFPDMSVIEEHANWSV 500
           PV HG E   + I  T G++P       E  C E E  + SS     + + IEE  +  +
Sbjct: 34  PVTHGTESSWHEIAATSGAHPEGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDGMI 93

Query: 501 SREAGFSYSH---AGLSNRLARDNELRENDKEQLKAISTRDPLSE 542
                 SY     +G SN      +L+E  K+QL+   +R+ LS+
Sbjct: 94  LGPEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSK 138


>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
           [Homo sapiens]
          Length = 739

 Score = 32.3 bits (72), Expect = 2.4
 Identities = 15/42 (35%), Positives = 26/42 (61%), Gaps = 5/42 (11%)

Query: 583 MYCLVKDWPPIKPEQAMELL-----DCNYPDPMVRGFAVRCL 619
           +Y  +  + P+KP+ A+  +     DC+ P+PMVRG A+R +
Sbjct: 68  VYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSM 109


>gi|13699803 WAS protein family, member 3 [Homo sapiens]
          Length = 502

 Score = 32.0 bits (71), Expect = 3.2
 Identities = 26/73 (35%), Positives = 32/73 (43%), Gaps = 15/73 (20%)

Query: 18 PRILVECLLPNGMIVTLECLREATLITI--------KH------ELFKEARKYPLH-QLL 62
          PR L    LP G+   LEC+  +TL  I        KH      ELF EA  + +    L
Sbjct: 10 PRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSL 69

Query: 63 QDESSYIFVSVTQ 75
          QD    + V VTQ
Sbjct: 70 QDRIDRLAVKVTQ 82


>gi|122937335 F-box protein 46 [Homo sapiens]
          Length = 603

 Score = 31.6 bits (70), Expect = 4.2
 Identities = 9/30 (30%), Positives = 18/30 (60%)

Query: 186 DKGQIIVVIWVIVSPNNDKQKYTLKINHDC 215
           D+G++++  W ++ P N K+K    + H C
Sbjct: 80  DEGRVLLDTWYVIKPGNTKEKVAFFVAHQC 109


>gi|13124883 HsKin17 protein [Homo sapiens]
          Length = 393

 Score = 31.2 bits (69), Expect = 5.5
 Identities = 32/143 (22%), Positives = 60/143 (41%), Gaps = 17/143 (11%)

Query: 613 GFAVRCLEK------YLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKA----LTNQR 662
           GF   C+ +       L  +   Q++    +  + + +L+ L  RF  K+     + N+ 
Sbjct: 40  GFKCHCMSESHQRQLLLASENPQQFMDYFSEEFRND-FLELLRRRFGTKRVHNNIVYNEY 98

Query: 663 IGHFFFWHLKSEMHNKTVSQRFGLLLESYCRAC----GMYLKHLNRQVEAMEKLINLTDI 718
           I H    H+ +            L  E  C+      G Y+++++R  E + + + L   
Sbjct: 99  ISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKK 158

Query: 719 LKQEKKDETQKVQMKFLVEQMRR 741
            KQ+  DE +    KF+ EQ+RR
Sbjct: 159 KKQDLDDEEKTA--KFIEEQVRR 179


>gi|7662162 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 31.2 bits (69), Expect = 5.5
 Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 22/157 (14%)

Query: 715 LTDILKQEKKDETQKVQMKFLVEQMRRPDF----MDALQGFLSPLNPAHQLGNLRLEECR 770
           + DI+        Q V +KFL       D+    ++++  F   L+     G +++E  +
Sbjct: 473 MDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGG--GKIKVEILK 530

Query: 771 IMSSAKRPLWLNWENPDIMSELLFQNNEIIFKN-GDDLRQDMLTLQIIRIMENIWQNQGL 829
           I+S+         ENPD++ +LL       F +  +   +  + +  + + E I+ N   
Sbjct: 531 ILSNFA-------ENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRA 583

Query: 830 DL--------RMLPYGCLSIGDCVGLIEVVRNSHTIM 858
           ++          L Y C + G CV  I  + N H ++
Sbjct: 584 EVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLL 620


>gi|29540562 ALEX2 protein [Homo sapiens]
          Length = 632

 Score = 31.2 bits (69), Expect = 5.5
 Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 22/157 (14%)

Query: 715 LTDILKQEKKDETQKVQMKFLVEQMRRPDF----MDALQGFLSPLNPAHQLGNLRLEECR 770
           + DI+        Q V +KFL       D+    ++++  F   L+     G +++E  +
Sbjct: 473 MDDIMASNLNSAVQVVGLKFLTNMTITNDYQHLLVNSIANFFRLLSQGG--GKIKVEILK 530

Query: 771 IMSSAKRPLWLNWENPDIMSELLFQNNEIIFKN-GDDLRQDMLTLQIIRIMENIWQNQGL 829
           I+S+         ENPD++ +LL       F +  +   +  + +  + + E I+ N   
Sbjct: 531 ILSNFA-------ENPDMLKKLLSTQVPASFSSLYNSYVESEILINALTLFEIIYDNLRA 583

Query: 830 DL--------RMLPYGCLSIGDCVGLIEVVRNSHTIM 858
           ++          L Y C + G CV  I  + N H ++
Sbjct: 584 EVFNYREFNKGSLFYLCTTSGVCVKKIRALANHHDLL 620


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.138    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,464,420
Number of Sequences: 37866
Number of extensions: 1862602
Number of successful extensions: 4065
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3963
Number of HSP's gapped (non-prelim): 52
length of query: 1068
length of database: 18,247,518
effective HSP length: 113
effective length of query: 955
effective length of database: 13,968,660
effective search space: 13340070300
effective search space used: 13340070300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.