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Search of human proteins with 53729352
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo
sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 964 0.0
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 872 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 80 3e-15
gi|16554627 WD repeat domain 5 [Homo sapiens] 80 3e-15
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 78 1e-14
gi|23199987 WD repeat domain 5B [Homo sapiens] 77 4e-14
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 74 3e-13
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 74 3e-13
gi|62234438 Notchless gene homolog isoform b [Homo sapiens] 72 1e-12
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 69 9e-12
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 69 9e-12
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 69 9e-12
gi|32189425 WD repeat domain 69 [Homo sapiens] 68 2e-11
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 67 3e-11
gi|13376840 WD repeat domain 61 [Homo sapiens] 67 3e-11
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 66 6e-11
gi|113865883 WD repeat domain 38 [Homo sapiens] 65 1e-10
gi|55743075 angio-associated, migratory cell protein [Homo sapiens] 65 1e-10
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 64 2e-10
gi|89886480 zinedin isoform 2 [Homo sapiens] 64 4e-10
gi|89886477 zinedin isoform 1 [Homo sapiens] 64 4e-10
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 64 4e-10
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 63 5e-10
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 63 5e-10
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 63 5e-10
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 63 5e-10
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 63 5e-10
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 63 5e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 63 5e-10
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 62 8e-10
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 964 bits (2491), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPD 60
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPD
Sbjct: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPD 60
Query: 61 GNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKI 120
GNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKI
Sbjct: 61 GNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKI 120
Query: 121 WDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHS 180
WDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHS
Sbjct: 121 WDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHS 180
Query: 181 KSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI 240
KSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI
Sbjct: 181 KSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI 240
Query: 241 SCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFS 300
SCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFS
Sbjct: 241 SCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFS 300
Query: 301 IDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHD 360
IDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHD
Sbjct: 301 IDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHD 360
Query: 361 GAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWT 420
GAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWT
Sbjct: 361 GAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWT 420
Query: 421 LSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY 466
LSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY
Sbjct: 421 LSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY 466
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 872 bits (2252), Expect = 0.0
Identities = 421/422 (99%), Positives = 421/422 (99%)
Query: 45 IDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP 104
I DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP
Sbjct: 185 IGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP 244
Query: 105 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL 164
DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL
Sbjct: 245 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL 304
Query: 165 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH
Sbjct: 305 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 364
Query: 225 TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV 284
TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV
Sbjct: 365 TNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVV 424
Query: 285 CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK 344
CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK
Sbjct: 425 CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGK 484
Query: 345 LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN 404
LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN
Sbjct: 485 LLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDN 544
Query: 405 EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI
Sbjct: 545 EHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 604
Query: 465 TY 466
TY
Sbjct: 605 TY 606
Score = 124 bits (312), Expect = 1e-28
Identities = 99/293 (33%), Positives = 139/293 (47%), Gaps = 27/293 (9%)
Query: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNID---------DHSRF 51
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNID +H+
Sbjct: 1 MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ 60
Query: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
V +++P G A+ G++ I+D E + + G I I+W+ DS ++
Sbjct: 61 VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKY-EYQPFAGKIKDIAWTEDSKR-IA 118
Query: 112 ASGDKTSK-----IWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 166
G+ K +WD S +SV G + + + + L+
Sbjct: 119 VVGEGREKFGAVFLWD-SGSSVGEI--TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFE 175
Query: 167 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG--KGH 224
P K I HS+ + C+ +G + + S DG I +D +TGE G K H
Sbjct: 176 GPPFKFKFTIGDHSRFVNCVRFSPDGNR--FATASADGQIYIYDGKTGEKVCALGGSKAH 233
Query: 225 TNQVSRMT-VDESGQLISCSMDDTVRYTSLMLRDYSG---QGVVKLDVQPKCV 273
+ ++ +S L+S S D T + + + G LD Q C+
Sbjct: 234 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCL 286
Score = 33.9 bits (76), Expect = 0.32
Identities = 31/118 (26%), Positives = 49/118 (41%), Gaps = 8/118 (6%)
Query: 31 NFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNR--FATASADGQIYIYDGKTGEKVCALG 88
N+L N L I HS+ + C+ +G + + S DG I +D +TGE G
Sbjct: 302 NYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG 361
Query: 89 GSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCL 146
K H + ++ +S L+S S D T + + + G LD Q C+
Sbjct: 362 --KGHTNQVSRMT-VDESGQLISCSMDDTVRYTSLMLRDYSG---QGVVKLDVQPKCV 413
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.5 bits (197), Expect = 3e-15
Identities = 70/218 (32%), Positives = 104/218 (47%), Gaps = 23/218 (10%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYI---YDGKTGEKVCALGGSKAHDGGIYAISWSP 104
H++ V+ V+FSP+G A++SAD I I YDGK + + H GI ++WS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI------SGHKLGISDVAWSS 97
Query: 105 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLW--QKDHLLSVSLSGYIN 162
DS L+SAS DKT KIWDVS + T S + C + Q + ++S S +
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV---FCCNFNPQSNLIVSGSFDESVR 154
Query: 163 YLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK 222
D K L + HS + VH N S I S S+DG WD+ +G+
Sbjct: 155 IWDVKT-GKCLKTLPAHSDPVS--AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 223 GHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 259
VS + +G+ +++ ++D+T L L DYS
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNT-----LKLWDYS 244
Score = 68.2 bits (165), Expect = 2e-11
Identities = 57/201 (28%), Positives = 93/201 (46%), Gaps = 20/201 (9%)
Query: 35 TNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 94
++GKC L+ + HS +V C F+P N + S D + I+D KTG+ + L AH
Sbjct: 117 SSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHS 171
Query: 95 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF-----PMGSTVLDQQLGCLWQK 149
+ A+ ++ D + ++S+S D +IWD + + T P S V G
Sbjct: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG----- 226
Query: 150 DHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVH--KNGGKSYIYSGSHDGHIN 207
++L+ +L + D + K L GH C+ + GGK +I SGS D +
Sbjct: 227 KYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVY 284
Query: 208 YWDSETGENDSFAGKGHTNQV 228
W+ +T E +GHT+ V
Sbjct: 285 IWNLQTKEIVQKL-QGHTDVV 304
Score = 55.8 bits (133), Expect = 8e-08
Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 15/221 (6%)
Query: 43 RNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISW 102
+ I H ++ V +S D N +AS D + I+D +G+ + L K H ++ ++
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNF 137
Query: 103 SPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLS--GY 160
+P S ++S S D++ +IWDV + T P S D + +D L VS S G
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGL 194
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
D + +I + + + NG YI + + D + WD G+
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLK-T 251
Query: 221 GKGHTNQ----VSRMTVDESGQLISCSMDDTVRYTSLMLRD 257
GH N+ + +V ++S S D+ V +L ++
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 39/317 (12%)
Query: 169 PSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
P KP + +K GH+K++ + NG ++ S S D I W + G+ + GH
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNG--EWLASSSADKLIKIWGAYDGKFEKTIS-GH 86
Query: 225 TNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYSGQG--VVKLDVQPKCVAVGP 277
+S + +S L+S S D T++ + L+ G V + P+ +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 278 GGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--PGGDTVAIGGVDGNVRLYSI- 334
G + V I + KC P + V AVH G + DG R++
Sbjct: 147 GSFDESVRIWDV----KTGKCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 335 ----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYG 390
L T + D+ PV+ V +S +G ++ + ++ + G + G
Sbjct: 202 SGQCLKTLIDDDNP------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT-YTG 254
Query: 391 HHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 447
H + C+ + + SG D +VY+W L E K+Q H +S+ E
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACHPTE 313
Query: 448 HTLVTTS--HDASVKEW 462
+ + + + +D ++K W
Sbjct: 314 NIIASAALENDKTIKLW 330
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 378 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLH 437
V Y+ GH + + +SP+ E AS D ++ +W D + K H+L
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKL- 88
Query: 438 HVSSLAW-LDEHTLVTTSHDASVKEWTIT 465
+S +AW D + LV+ S D ++K W ++
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVS 117
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 80.5 bits (197), Expect = 3e-15
Identities = 70/218 (32%), Positives = 104/218 (47%), Gaps = 23/218 (10%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYI---YDGKTGEKVCALGGSKAHDGGIYAISWSP 104
H++ V+ V+FSP+G A++SAD I I YDGK + + H GI ++WS
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI------SGHKLGISDVAWSS 97
Query: 105 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLW--QKDHLLSVSLSGYIN 162
DS L+SAS DKT KIWDVS + T S + C + Q + ++S S +
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV---FCCNFNPQSNLIVSGSFDESVR 154
Query: 163 YLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK 222
D K L + HS + VH N S I S S+DG WD+ +G+
Sbjct: 155 IWDVKT-GKCLKTLPAHSDPVS--AVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 223 GHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 259
VS + +G+ +++ ++D+T L L DYS
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNT-----LKLWDYS 244
Score = 68.2 bits (165), Expect = 2e-11
Identities = 57/201 (28%), Positives = 93/201 (46%), Gaps = 20/201 (9%)
Query: 35 TNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 94
++GKC L+ + HS +V C F+P N + S D + I+D KTG+ + L AH
Sbjct: 117 SSGKC--LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHS 171
Query: 95 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF-----PMGSTVLDQQLGCLWQK 149
+ A+ ++ D + ++S+S D +IWD + + T P S V G
Sbjct: 172 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG----- 226
Query: 150 DHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVH--KNGGKSYIYSGSHDGHIN 207
++L+ +L + D + K L GH C+ + GGK +I SGS D +
Sbjct: 227 KYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVY 284
Query: 208 YWDSETGENDSFAGKGHTNQV 228
W+ +T E +GHT+ V
Sbjct: 285 IWNLQTKEIVQKL-QGHTDVV 304
Score = 55.8 bits (133), Expect = 8e-08
Identities = 53/221 (23%), Positives = 94/221 (42%), Gaps = 15/221 (6%)
Query: 43 RNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISW 102
+ I H ++ V +S D N +AS D + I+D +G+ + L K H ++ ++
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL---KGHSNYVFCCNF 137
Query: 103 SPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLS--GY 160
+P S ++S S D++ +IWDV + T P S D + +D L VS S G
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGL 194
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
D + +I + + + NG YI + + D + WD G+
Sbjct: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNG--KYILAATLDNTLKLWDYSKGKCLK-T 251
Query: 221 GKGHTNQ----VSRMTVDESGQLISCSMDDTVRYTSLMLRD 257
GH N+ + +V ++S S D+ V +L ++
Sbjct: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 292
Score = 49.3 bits (116), Expect = 7e-06
Identities = 70/317 (22%), Positives = 126/317 (39%), Gaps = 39/317 (12%)
Query: 169 PSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
P KP + +K GH+K++ + NG ++ S S D I W + G+ + GH
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNG--EWLASSSADKLIKIWGAYDGKFEKTIS-GH 86
Query: 225 TNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYSGQG--VVKLDVQPKCVAVGP 277
+S + +S L+S S D T++ + L+ G V + P+ +
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 278 GGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--PGGDTVAIGGVDGNVRLYSI- 334
G + V I + KC P + V AVH G + DG R++
Sbjct: 147 GSFDESVRIWDV----KTGKCLKT-LPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 335 ----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYG 390
L T + D+ PV+ V +S +G ++ + ++ + G + G
Sbjct: 202 SGQCLKTLIDDDNP------PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT-YTG 254
Query: 391 HHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 447
H + C+ + + SG D +VY+W L E K+Q H +S+ E
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACHPTE 313
Query: 448 HTLVTTS--HDASVKEW 462
+ + + + +D ++K W
Sbjct: 314 NIIASAALENDKTIKLW 330
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 378 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLH 437
V Y+ GH + + +SP+ E AS D ++ +W D + K H+L
Sbjct: 31 VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKL- 88
Query: 438 HVSSLAW-LDEHTLVTTSHDASVKEWTIT 465
+S +AW D + LV+ S D ++K W ++
Sbjct: 89 GISDVAWSSDSNLLVSASDDKTLKIWDVS 117
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 78.2 bits (191), Expect = 1e-14
Identities = 91/390 (23%), Positives = 149/390 (38%), Gaps = 29/390 (7%)
Query: 44 NIDDHSRFVNCVRFSPDGNRFATASADGQIYIYD--GKTGEKVCALGGSKAHDGGIYAIS 101
+++ HS V V FSP G A+ S D + +D +T C K H + +IS
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC-----KGHRHWVLSIS 163
Query: 102 WSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDH-------LLS 154
WSPD L S + +WD S V G + G W+ H + S
Sbjct: 164 WSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHS--KWITGLSWEPLHANPECRYVAS 221
Query: 155 VSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETG 214
S G + D + ++ GH++S+ CL + GG +YS S D I W + G
Sbjct: 222 SSKDGSVRIWD-TTAGRCERILTGHTQSVTCL---RWGGDGLLYSASQDRTIKVWRAHDG 277
Query: 215 ENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVA 274
+GH + V+ M + L + + + + S Q + + + +
Sbjct: 278 VLCRTL-QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 275 VGPGGYAVVVCIGQIVLL-----KDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNV 329
G G +V L +D++ + V P VA D ++
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 330 RLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFY 389
+L+ G T K L V +A+S D L + + V+ V ++
Sbjct: 397 KLWD--GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL-P 453
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
GH ++ + WSPD + ASGG D + +W
Sbjct: 454 GHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 72.0 bits (175), Expect = 1e-12
Identities = 40/118 (33%), Positives = 61/118 (51%), Gaps = 4/118 (3%)
Query: 17 RGVSKIIGGDPKGNNFLYTNGKCVI-LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYI 75
+G +++ G FL++ + L + H +N V FSPD A+AS D I +
Sbjct: 339 QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKL 398
Query: 76 YDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFP 133
+DG+TG+ + +L G H +Y I+WS DS L+S S D T K+WDV + P
Sbjct: 399 WDGRTGKYLASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP 453
Score = 42.0 bits (97), Expect = 0.001
Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 15/160 (9%)
Query: 311 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP---VTDVAYSHDGAFLAVC 367
VA P G +A G D VR + L E KG V +++S DG LA
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWD-----LSTETPHFTCKGHRHWVLSISWSPDGRKLASG 174
Query: 368 DASKVVTVFSVADGYSENNVFYGHHAKIVCLAW-----SPDNEHFASGGMDMMVYVWTLS 422
+ + ++ + G GH I L+W +P+ + AS D V +W +
Sbjct: 175 CKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTT 234
Query: 423 DPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 462
+I H V+ L W + L + S D ++K W
Sbjct: 235 AGRCE-RILTGHT-QSVTCLRWGGDGLLYSASQDRTIKVW 272
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/122 (25%), Positives = 54/122 (44%), Gaps = 12/122 (9%)
Query: 352 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 411
V VA+S G +LA V + ++ + + GH ++ ++WSPD ASG
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTE-TPHFTCKGHRHWVLSISWSPDGRKLASGC 175
Query: 412 MDMMVYVWTLSDPETRVKIQDAHRLHH--VSSLAWLDEHT------LVTTSHDASVKEWT 463
+ + +W DP T ++ H ++ L+W H + ++S D SV+ W
Sbjct: 176 KNGQILLW---DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 464 IT 465
T
Sbjct: 233 TT 234
Score = 35.4 bits (80), Expect = 0.11
Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 2/55 (3%)
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAW 444
GH ++ +A+SP ++ ASG D V W LS ET HR H V S++W
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLS-TETPHFTCKGHR-HWVLSISW 164
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 76.6 bits (187), Expect = 4e-14
Identities = 67/225 (29%), Positives = 106/225 (47%), Gaps = 21/225 (9%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGI 97
KC ++ H+ V+ V+FSP+G A++SAD I I+ G+ L G H+ I
Sbjct: 34 KCTLV----GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYG---HNLEI 86
Query: 98 YAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQ--KDHLLSV 155
++WS DS+ L+SAS DKT K+WDV + T S + C + + ++S
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV---FCCNFNPPSNLIISG 143
Query: 156 SLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 215
S + + K L + HS + VH N S I SGS+DG WD+ +G+
Sbjct: 144 SFDETVKIWEVKT-GKCLKTLSAHSDPVS--AVHFNCSGSLIVSGSYDGLCRIWDAASGQ 200
Query: 216 NDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 259
VS + +G+ +++ ++D+T L L DYS
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT-----LKLWDYS 240
Score = 49.7 bits (117), Expect = 6e-06
Identities = 73/337 (21%), Positives = 137/337 (40%), Gaps = 40/337 (11%)
Query: 149 KDHLLSVSLSGYINYLDRNNPSKPLHVIK----GHSKSIQCLTVHKNGGKSYIYSGSHDG 204
+D ++LS N + P P + +K GH++++ + NG ++ S S D
Sbjct: 7 RDAKAQLALSSSANQ-SKEVPENPNYALKCTLVGHTEAVSSVKFSPNG--EWLASSSADR 63
Query: 205 HINYWDSETGENDSFAGKGHTNQVSRMT-VDESGQLISCSMDDTVRYTSLM----LRDYS 259
I W + G+ + GH ++S + +S +L+S S D T++ + L+
Sbjct: 64 LIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK 122
Query: 260 GQG--VVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVH--P 315
G V + P + G + V I ++ KC + +P V AVH
Sbjct: 123 GHSNYVFCCNFNPPSNLIISGSFDETVKIWEV----KTGKCLKTLSAHSDP-VSAVHFNC 177
Query: 316 GGDTVAIGGVDGNVRLYSI-----LGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDAS 370
G + G DG R++ L T + D+ PV+ V +S +G ++
Sbjct: 178 SGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP------PVSFVKFSPNGKYILTATLD 231
Query: 371 KVVTVFSVADGYSENNVFYGHHAKIVCLAWS---PDNEHFASGGMDMMVYVWTLSDPETR 427
+ ++ + G + GH + C+ + + SG D +VY+W L E
Sbjct: 232 NTLKLWDYSRGRCLKT-YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
Query: 428 VKIQDAHRLHHVSSLAWLDEHTLVTTS--HDASVKEW 462
K+Q H +S+ E+ + + + +D ++K W
Sbjct: 291 QKLQ-GHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 46.6 bits (109), Expect = 5e-05
Identities = 28/96 (29%), Positives = 50/96 (52%), Gaps = 4/96 (4%)
Query: 37 GKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 96
GKC L+ + HS V+ V F+ G+ + S DG I+D +G+ + L +
Sbjct: 157 GKC--LKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDD--NPP 212
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 132
+ + +SP+ ++L+A+ D T K+WD S + T+
Sbjct: 213 VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY 248
Score = 45.8 bits (107), Expect = 8e-05
Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 352 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 411
V+ V +S +G +LA A +++ ++ DG E + YGH+ +I +AWS D+ S
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL-YGHNLEISDVAWSSDSSRLVSAS 102
Query: 412 MDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
D + +W + + +K H + + +++ S D +VK W +
Sbjct: 103 DDKTLKLWDVRSGKC-LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Score = 38.9 bits (89), Expect = 0.010
Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 382 YSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSS 441
Y+ GH + + +SP+ E AS D ++ +W D + K H L +S
Sbjct: 31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-KTLYGHNL-EISD 88
Query: 442 LAW-LDEHTLVTTSHDASVKEWTI 464
+AW D LV+ S D ++K W +
Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDV 112
Score = 38.9 bits (89), Expect = 0.010
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 1/94 (1%)
Query: 36 NGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDG 95
+G+C + +DD + V+ V+FSP+G TA+ D + ++D G + G K
Sbjct: 198 SGQC-LKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKY 256
Query: 96 GIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVV 129
I+A ++S S D IW++ +V
Sbjct: 257 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 73.9 bits (180), Expect = 3e-13
Identities = 93/434 (21%), Positives = 164/434 (37%), Gaps = 79/434 (18%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + ++S D
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCAFSTDDR 670
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN 167
+ + S DK KIW+ S++G +
Sbjct: 671 FIATCSVDKKVKIWN---------------------------------SMTGEL------ 691
Query: 168 NPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSFAGKGHT 225
+H HS+ + C + + +GS D + WD E N F GHT
Sbjct: 692 -----VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF---GHT 743
Query: 226 NQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------LDVQPKC 272
N V+ +L+ SCS D T++ + VK ++V KC
Sbjct: 744 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 803
Query: 273 VAVGPGGYAVVVCI-GQIVLLKDQRKCFSIDNPGYEPEV--VAVHPGGDTVAIGGVDGNV 329
+ G ++V +I L + D G+ V V P G + D +
Sbjct: 804 CSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 863
Query: 330 RLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFY 389
RL+ K+ +L+ + DV + + + D + + + + G + Y
Sbjct: 864 RLWE-TKKVCKNSAVMLKQE---VDVVFQENEVMVLAVDHIRRLQLINGRTG----QIDY 915
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSLAWLDEH 448
A++ C SP ++ A G + + + L + + + Q + H+ A DE
Sbjct: 916 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA--DEK 973
Query: 449 TLVTTSHDASVKEW 462
TL+++S DA ++ W
Sbjct: 974 TLISSSDDAEIQVW 987
Score = 55.5 bits (132), Expect = 1e-07
Identities = 90/417 (21%), Positives = 164/417 (39%), Gaps = 85/417 (20%)
Query: 46 DDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPD 105
+D V C +S DG R A A +I++++ + KV G H ++ + +SPD
Sbjct: 795 EDMEVIVKCCSWSADGARIMVA-AKNKIFLWNTDSRSKVADCRG---HLSWVHGVMFSPD 850
Query: 106 STHLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL----S 158
+ L++S D+T ++W+ V NS V V + + DH+ + L +
Sbjct: 851 GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRT 910
Query: 159 GYINYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLTVHK 190
G I+YL D N + L ++ H K++ +
Sbjct: 911 GQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTV--WHIQF 968
Query: 191 NGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRY 250
+ + S S D I W+ + + +GH V + ++ +L+S S D TV+
Sbjct: 969 TADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1026
Query: 251 TSLML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR----- 296
+++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1027 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGC 1086
Query: 297 ---KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEGKLL 346
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1087 VRCSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
Query: 347 EAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 403
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1133 HG-GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1185
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE--KVCA---LGGSKAHDGG 96
L + H+ V C FS D AT +G+I I++ GE +CA G+ H G
Sbjct: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVL 139
+ + +SPD L+SA G K W+V TF T L
Sbjct: 1137 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNL 1177
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 351 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 406
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 671
Query: 407 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 461
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 672 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 727
Query: 462 WTI 464
W +
Sbjct: 728 WDL 730
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/182 (24%), Positives = 67/182 (36%), Gaps = 61/182 (33%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK----VCALGGSKAH 93
KC+ LR H V R + +R + S DG + +++ TG K VC H
Sbjct: 993 KCIFLRG---HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVC-------H 1041
Query: 94 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLL 153
G + + S D+T S S DKT+KIW D LL
Sbjct: 1042 QGTVLSCDISHDATKFSSTSADKTAKIWSF--------------------------DLLL 1075
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
PLH ++GH+ ++C + + + +G +G I W+
Sbjct: 1076 ------------------PLHELRGHNGCVRCSAFSVD--STLLATGDDNGEIRIWNVSN 1115
Query: 214 GE 215
GE
Sbjct: 1116 GE 1117
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
++ D+HS VNC F+ + A+ ++ +K C H +
Sbjct: 691 LVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR-NTMFGHTNSVNHC 749
Query: 101 SWSPDSTHLLSASGDKTSKIWDVS 124
+SPD L S S D T K+WD +
Sbjct: 750 RFSPDDKLLASCSADGTLKLWDAT 773
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 73.9 bits (180), Expect = 3e-13
Identities = 93/434 (21%), Positives = 164/434 (37%), Gaps = 79/434 (18%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + ++S D
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCAFSTDDR 659
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN 167
+ + S DK KIW+ S++G +
Sbjct: 660 FIATCSVDKKVKIWN---------------------------------SMTGEL------ 680
Query: 168 NPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSFAGKGHT 225
+H HS+ + C + + +GS D + WD E N F GHT
Sbjct: 681 -----VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF---GHT 732
Query: 226 NQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------LDVQPKC 272
N V+ +L+ SCS D T++ + VK ++V KC
Sbjct: 733 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 792
Query: 273 VAVGPGGYAVVVCI-GQIVLLKDQRKCFSIDNPGYEPEV--VAVHPGGDTVAIGGVDGNV 329
+ G ++V +I L + D G+ V V P G + D +
Sbjct: 793 CSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTI 852
Query: 330 RLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFY 389
RL+ K+ +L+ + DV + + + D + + + + G + Y
Sbjct: 853 RLWE-TKKVCKNSAVMLKQE---VDVVFQENEVMVLAVDHIRRLQLINGRTG----QIDY 904
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSLAWLDEH 448
A++ C SP ++ A G + + + L + + + Q + H+ A DE
Sbjct: 905 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA--DEK 962
Query: 449 TLVTTSHDASVKEW 462
TL+++S DA ++ W
Sbjct: 963 TLISSSDDAEIQVW 976
Score = 55.5 bits (132), Expect = 1e-07
Identities = 90/417 (21%), Positives = 164/417 (39%), Gaps = 85/417 (20%)
Query: 46 DDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPD 105
+D V C +S DG R A A +I++++ + KV G H ++ + +SPD
Sbjct: 784 EDMEVIVKCCSWSADGARIMVA-AKNKIFLWNTDSRSKVADCRG---HLSWVHGVMFSPD 839
Query: 106 STHLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL----S 158
+ L++S D+T ++W+ V NS V V + + DH+ + L +
Sbjct: 840 GSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRT 899
Query: 159 GYINYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLTVHK 190
G I+YL D N + L ++ H K++ +
Sbjct: 900 GQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTV--WHIQF 957
Query: 191 NGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRY 250
+ + S S D I W+ + + +GH V + ++ +L+S S D TV+
Sbjct: 958 TADEKTLISSSDDAEIQVWNWQL--DKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1015
Query: 251 TSLML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR----- 296
+++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1016 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGC 1075
Query: 297 ---KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEGKLL 346
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1076 VRCSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
Query: 347 EAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 403
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1122 HG-GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1174
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE--KVCA---LGGSKAHDGG 96
L + H+ V C FS D AT +G+I I++ GE +CA G+ H G
Sbjct: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVL 139
+ + +SPD L+SA G K W+V TF T L
Sbjct: 1126 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNL 1166
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 351 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 406
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 660
Query: 407 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 461
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 661 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 716
Query: 462 WTI 464
W +
Sbjct: 717 WDL 719
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/182 (24%), Positives = 67/182 (36%), Gaps = 61/182 (33%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK----VCALGGSKAH 93
KC+ LR H V R + +R + S DG + +++ TG K VC H
Sbjct: 982 KCIFLRG---HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVC-------H 1030
Query: 94 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLL 153
G + + S D+T S S DKT+KIW D LL
Sbjct: 1031 QGTVLSCDISHDATKFSSTSADKTAKIWSF--------------------------DLLL 1064
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
PLH ++GH+ ++C + + + +G +G I W+
Sbjct: 1065 ------------------PLHELRGHNGCVRCSAFSVD--STLLATGDDNGEIRIWNVSN 1104
Query: 214 GE 215
GE
Sbjct: 1105 GE 1106
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
++ D+HS VNC F+ + A+ ++ +K C H +
Sbjct: 680 LVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR-NTMFGHTNSVNHC 738
Query: 101 SWSPDSTHLLSASGDKTSKIWDVS 124
+SPD L S S D T K+WD +
Sbjct: 739 RFSPDDKLLASCSADGTLKLWDAT 762
>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
Length = 193
Score = 72.0 bits (175), Expect = 1e-12
Identities = 40/118 (33%), Positives = 61/118 (51%), Gaps = 4/118 (3%)
Query: 17 RGVSKIIGGDPKGNNFLYTNGKCVI-LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYI 75
+G +++ G FL++ + L + H +N V FSPD A+AS D I +
Sbjct: 47 QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKL 106
Query: 76 YDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFP 133
+DG+TG+ + +L G H +Y I+WS DS L+S S D T K+WDV + P
Sbjct: 107 WDGRTGKYLASLRG---HVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLP 161
Score = 39.7 bits (91), Expect = 0.006
Identities = 29/109 (26%), Positives = 46/109 (42%), Gaps = 3/109 (2%)
Query: 311 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDAS 370
V P VA D +++L+ G T K L V +A+S D L +
Sbjct: 86 VLFSPDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSD 143
Query: 371 KVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
+ V+ V ++ GH ++ + WSPD + ASGG D + +W
Sbjct: 144 STLKVWDVKAQKLAMDL-PGHADEVYAVDWSPDGQRVASGGKDKCLRIW 191
Score = 33.1 bits (74), Expect = 0.55
Identities = 21/76 (27%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAW-LDEH 448
GH A I + +SPD+ AS D + +W + ++ + V +AW D
Sbjct: 78 GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRG--HVAAVYQIAWSADSR 135
Query: 449 TLVTTSHDASVKEWTI 464
LV+ S D+++K W +
Sbjct: 136 LLVSGSSDSTLKVWDV 151
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 68.9 bits (167), Expect = 9e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 21/210 (10%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L+ DDH + C++F GNR + S D + ++ TG+ + L G H GG+++
Sbjct: 257 VLKGHDDH--VITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVG---HTGGVWSS 309
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVST-FPMGSTVLDQQLGCLWQKDHLLSVSLSG 159
+ ++S S D+T K+W+ + T + STV L + ++S S
Sbjct: 310 QMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDA 363
Query: 160 YINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSF 219
+ D + LHV+ GH +++C V +G + + SG++D + WD ET E
Sbjct: 364 TLRVWDIET-GQCLHVLMGHVAAVRC--VQYDGRR--VVSGAYDFMVKVWDPET-ETCLH 417
Query: 220 AGKGHTNQVSRMTVDESGQLISCSMDDTVR 249
+GHTN+V + D ++S S+D ++R
Sbjct: 418 TLQGHTNRVYSLQFD-GIHVVSGSLDTSIR 446
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/182 (24%), Positives = 85/182 (46%), Gaps = 20/182 (10%)
Query: 37 GKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 96
G+C L + H V CV++ DG R + + D + ++D +T + L G H
Sbjct: 373 GQC--LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNR 425
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 156
+Y++ + D H++S S D + ++WDV + + T ++ G + + L+S +
Sbjct: 426 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGN 480
Query: 157 LSGYINYLDRNNPSKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
+ D + L ++G H ++ CL +KN ++ + S DG + WD +T
Sbjct: 481 ADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKT 535
Query: 214 GE 215
GE
Sbjct: 536 GE 537
Score = 35.8 bits (81), Expect = 0.085
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 386 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 444
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 377 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 431
Query: 445 LDEHTLVTTSHDASVKEWTI 464
H +V+ S D S++ W +
Sbjct: 432 DGIH-VVSGSLDTSIRVWDV 450
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 68.9 bits (167), Expect = 9e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 21/210 (10%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L+ DDH + C++F GNR + S D + ++ TG+ + L G H GG+++
Sbjct: 375 VLKGHDDH--VITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVG---HTGGVWSS 427
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVST-FPMGSTVLDQQLGCLWQKDHLLSVSLSG 159
+ ++S S D+T K+W+ + T + STV L + ++S S
Sbjct: 428 QMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDA 481
Query: 160 YINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSF 219
+ D + LHV+ GH +++C V +G + + SG++D + WD ET E
Sbjct: 482 TLRVWDIET-GQCLHVLMGHVAAVRC--VQYDGRR--VVSGAYDFMVKVWDPET-ETCLH 535
Query: 220 AGKGHTNQVSRMTVDESGQLISCSMDDTVR 249
+GHTN+V + D ++S S+D ++R
Sbjct: 536 TLQGHTNRVYSLQFD-GIHVVSGSLDTSIR 564
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/182 (24%), Positives = 85/182 (46%), Gaps = 20/182 (10%)
Query: 37 GKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 96
G+C L + H V CV++ DG R + + D + ++D +T + L G H
Sbjct: 491 GQC--LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNR 543
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 156
+Y++ + D H++S S D + ++WDV + + T ++ G + + L+S +
Sbjct: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGN 598
Query: 157 LSGYINYLDRNNPSKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
+ D + L ++G H ++ CL +KN ++ + S DG + WD +T
Sbjct: 599 ADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKT 653
Query: 214 GE 215
GE
Sbjct: 654 GE 655
Score = 35.8 bits (81), Expect = 0.085
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 386 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 444
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 495 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 549
Query: 445 LDEHTLVTTSHDASVKEWTI 464
H +V+ S D S++ W +
Sbjct: 550 DGIH-VVSGSLDTSIRVWDV 568
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 68.9 bits (167), Expect = 9e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 21/210 (10%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L+ DDH + C++F GNR + S D + ++ TG+ + L G H GG+++
Sbjct: 295 VLKGHDDH--VITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVG---HTGGVWSS 347
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVST-FPMGSTVLDQQLGCLWQKDHLLSVSLSG 159
+ ++S S D+T K+W+ + T + STV L + ++S S
Sbjct: 348 QMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDA 401
Query: 160 YINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSF 219
+ D + LHV+ GH +++C V +G + + SG++D + WD ET E
Sbjct: 402 TLRVWDIET-GQCLHVLMGHVAAVRC--VQYDGRR--VVSGAYDFMVKVWDPET-ETCLH 455
Query: 220 AGKGHTNQVSRMTVDESGQLISCSMDDTVR 249
+GHTN+V + D ++S S+D ++R
Sbjct: 456 TLQGHTNRVYSLQFD-GIHVVSGSLDTSIR 484
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/182 (24%), Positives = 85/182 (46%), Gaps = 20/182 (10%)
Query: 37 GKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 96
G+C L + H V CV++ DG R + + D + ++D +T + L G H
Sbjct: 411 GQC--LHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQG---HTNR 463
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 156
+Y++ + D H++S S D + ++WDV + + T ++ G + + L+S +
Sbjct: 464 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTS---GMELKDNILVSGN 518
Query: 157 LSGYINYLDRNNPSKPLHVIKG---HSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
+ D + L ++G H ++ CL +KN ++ + S DG + WD +T
Sbjct: 519 ADSTVKIWDIKT-GQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDLKT 573
Query: 214 GE 215
GE
Sbjct: 574 GE 575
Score = 35.8 bits (81), Expect = 0.085
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 7/80 (8%)
Query: 386 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAH-RLHHVSSLAW 444
+V GH A + C+ + D SG D MV VW DPET + + V SL +
Sbjct: 415 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVW---DPETETCLHTLQGHTNRVYSLQF 469
Query: 445 LDEHTLVTTSHDASVKEWTI 464
H +V+ S D S++ W +
Sbjct: 470 DGIH-VVSGSLDTSIRVWDV 488
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 68.2 bits (165), Expect = 2e-11
Identities = 54/204 (26%), Positives = 97/204 (47%), Gaps = 11/204 (5%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
HS + + F+ G+R T S D + ++D TG KV L G H I + S++ D +
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG---HCAEISSASFNWDCS 274
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFP-MGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 166
+L+ S DKT K+WD + V+T +LD C L++ + + +
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDS---CFDYTGKLIATASADGTARIFS 331
Query: 167 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTN 226
K + ++GH I ++ + G +++ +GS D WD++TG+ +GHT+
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQG--NHLLTGSSDKTARIWDAQTGQCLQVL-EGHTD 388
Query: 227 QVSRMTVDESGQL-ISCSMDDTVR 249
++ + G + I+ S D+T R
Sbjct: 389 EIFSCAFNYKGNIVITGSKDNTCR 412
Score = 63.5 bits (153), Expect = 4e-10
Identities = 37/88 (42%), Positives = 47/88 (53%), Gaps = 5/88 (5%)
Query: 35 TNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 94
TNGKCV D +C F G ATASADG I+ T + + L G H+
Sbjct: 291 TNGKCVATLTGHDDEILDSC--FDYTGKLIATASADGTARIFSAATRKCIAKLEG---HE 345
Query: 95 GGIYAISWSPDSTHLLSASGDKTSKIWD 122
G I IS++P HLL+ S DKT++IWD
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 62.0 bits (149), Expect = 1e-09
Identities = 57/217 (26%), Positives = 96/217 (44%), Gaps = 10/217 (4%)
Query: 42 LRNIDDHSRFVNCVRFS-PDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
L ++ H V + F+ P G++ AT S D ++ +TG+ G H I +
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG---HTAEIVCL 183
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 160
S++P ST + + S D T+K+WD+ V T G + L D +++ S
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL-RGHSAEIISLSFNTSGDRIITGSFDHT 242
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
+ D + K ++++ GH I + N S I +GS D WD+ G+ +
Sbjct: 243 VVVWDADTGRK-VNILIGHCAEISSASF--NWDCSLILTGSMDKTCKLWDATNGKCVATL 299
Query: 221 GKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLR 256
GH +++ D +G+LI + S D T R S R
Sbjct: 300 -TGHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/154 (26%), Positives = 68/154 (44%), Gaps = 7/154 (4%)
Query: 311 VAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEA-KGPVTDVAYSHD-GAFLAVCD 368
VA++ G G D +L+ T +E LE + V +A+++ G +A
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWD---TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 369 ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRV 428
K ++SV G + F GH A+IVCL+++P + A+G MD +W + + E V
Sbjct: 155 FDKTCKLWSVETGKCYHT-FRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE-EV 212
Query: 429 KIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 462
H +S ++T S D +V W
Sbjct: 213 YTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 43.9 bits (102), Expect = 3e-04
Identities = 23/84 (27%), Positives = 44/84 (52%), Gaps = 5/84 (5%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGI 97
KC+ ++ H ++ + F+P GN T S+D I+D +TG+ + L G H I
Sbjct: 336 KCIA--KLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEI 390
Query: 98 YAISWSPDSTHLLSASGDKTSKIW 121
++ +++ +++ S D T +IW
Sbjct: 391 FSCAFNYKGNIVITGSKDNTCRIW 414
Score = 40.4 bits (93), Expect = 0.003
Identities = 60/337 (17%), Positives = 123/337 (36%), Gaps = 58/337 (17%)
Query: 175 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVD 234
V+K H + + ++K+G S +GS+D WD+ +GE + +GH N V + +
Sbjct: 87 VLKAHILPLTNVALNKSG--SCFITGSYDRTCKLWDTASGEELNTL-EGHRNVVYAIAFN 143
Query: 235 E--SGQLISCSMDDTVRYTSL-------MLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVC 285
++ + S D T + S+ R ++ + +V L P+ V G
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE-IVCLSFNPQSTLVATGSMDTTAK 202
Query: 286 IGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYS------------ 333
+ I ++ + +++ E ++ + GD + G D V ++
Sbjct: 203 LWDI---QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259
Query: 334 ----------------ILGTTLKDEGKLLEAKG------------PVTDVAYSHDGAFLA 365
IL ++ KL +A + D + + G +A
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 366 VCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPE 425
A +FS A + GH +I ++++P H +G D +W +
Sbjct: 320 TASADGTARIFSAATRKCIAKL-EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Query: 426 TRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 462
+++ + H S + ++T S D + + W
Sbjct: 379 C-LQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 67.4 bits (163), Expect = 3e-11
Identities = 96/435 (22%), Positives = 161/435 (37%), Gaps = 45/435 (10%)
Query: 55 VRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASG 114
V SPDG+R A I IY +G + +A D + A++W L+S +
Sbjct: 1933 VALSPDGDRVAVGYRADGIRIYKISSGSQGAQ---GQALDVAVSALAWLSPKV-LVSGAE 1988
Query: 115 DKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLH 174
D + + W + S+ S + + S LG ++ L S S + R ++P
Sbjct: 1989 DGSLQGWALKECSLQSLWLL-SRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHK 2047
Query: 175 V--------IKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEND----SFAGK 222
++GH + C + +GG + +G D + WD T + SF
Sbjct: 2048 AEDFPCGTELRGHEGPVSCCSFSTDGGS--LATGGRDRSLLCWDVRTPKTPVLIHSFPAC 2105
Query: 223 GHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAV 282
H + V+ + LISCS D +V + SGQ + + V+
Sbjct: 2106 -HRDWVTGCAWTKDNLLISCSSDGSVG----LWDPESGQRLGQFLGHQSAVSAVAAVEEH 2160
Query: 283 VVCIGQIVLLK--DQRKCFSIDNPGYEPEV----------VAVHPGGDTVAIG-GVDGNV 329
VV + + LK D + P + + A PG + + + G+DG
Sbjct: 2161 VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT 2220
Query: 330 RLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFY 389
RL+ L + LL GPV A S + V ++ V +++
Sbjct: 2221 RLWHPL--LVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKE-ADDTCIP 2277
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHT 449
A + +AW+PD SG + +W + + A H+ +L W HT
Sbjct: 2278 RSSAAVTAVAWAPDGSMAVSGNQAGELILW-----QEAKAVATAQAPGHIGALIWSSAHT 2332
Query: 450 LVTTSHDASVKEWTI 464
S D + EW +
Sbjct: 2333 FFVLSADEKISEWQV 2347
Score = 58.5 bits (140), Expect = 1e-08
Identities = 96/428 (22%), Positives = 165/428 (38%), Gaps = 32/428 (7%)
Query: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
++ F D F TA DG + ++D + G C + +KAH I SPD L +
Sbjct: 1721 ISACLFLSDDTLFLTAF-DGLLELWDLQHG---CRVLQTKAHQYQITGCCLSPDCRLLAT 1776
Query: 112 ASGDKTSKIWDVSVNSVV--STFPMGSTVLDQQLGCLW---QKDHLLSVSLSGYINYLDR 166
K+WD + T+P + L C+ + + + S +G I++
Sbjct: 1777 VCLGGCLKLWDTVRGQLAFQHTYP-------KSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
Query: 167 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTN 226
+ K + SI+ L + GG + G D + W G + H
Sbjct: 1830 DG-LKVTKDLGAPGASIRTLAFNVPGG--VVAVGRLDSMVELWAWREGARLAAFPAHHGF 1886
Query: 227 QVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKC-VAVGPGGYAVVVC 285
+ + + QL++ D V+ S L G + L + P VA+ P G V V
Sbjct: 1887 VAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGH-LGSLSLSPALSVALSPDGDRVAVG 1945
Query: 286 IGQ--IVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGV-DGNVRLYSILGTTLKDE 342
I + K + V A+ V + G DG+++ +++ +L+
Sbjct: 1946 YRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSL 2005
Query: 343 GKLLEAKGPVTDVAYSHDGAFLAVCDAS------KVVTVFSVADGYSENNVFYGHHAKIV 396
L + PV +A S + A D + +++T A+ + GH +
Sbjct: 2006 WLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVS 2065
Query: 397 CLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHH--VSSLAWLDEHTLVTTS 454
C ++S D A+GG D + W + P+T V I H V+ AW ++ L++ S
Sbjct: 2066 CCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCS 2125
Query: 455 HDASVKEW 462
D SV W
Sbjct: 2126 SDGSVGLW 2133
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/354 (20%), Positives = 135/354 (38%), Gaps = 25/354 (7%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA-HDGGIYAISWSPDS 106
H V+C FS DG AT D + +D +T + + A H + +W+ D+
Sbjct: 2060 HEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDN 2119
Query: 107 THLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 166
L+S S D + +WD + F +G + + ++H++SVS G + D
Sbjct: 2120 L-LISCSSDGSVGLWDPESGQRLGQF-LGHQSAVSAVAAV--EEHVVSVSRDGTLKVWDH 2175
Query: 167 NN---PSKPLH--VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG 221
S P H I + +++ + G + + + DG W +
Sbjct: 2176 QGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLL-VCQTHTL 2234
Query: 222 KGHTNQVSRMTVDE-SGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY 280
GH+ V V E SG +++ S D +VR + ++ + + VA P G
Sbjct: 2235 LGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVP-KEADDTCIPRSSAAVTAVAWAPDGS 2293
Query: 281 AVVV--CIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSIL--- 335
V G+++L ++ + + PG+ + + T + D + + +
Sbjct: 2294 MAVSGNQAGELILWQEAKAVATAQAPGHIGAL--IWSSAHTFFVLSADEKISEWQVKLRK 2351
Query: 336 -----GTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSE 384
+L L E G +T + ++ DG FL + A + D SE
Sbjct: 2352 GSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDAPSE 2405
Score = 46.6 bits (109), Expect = 5e-05
Identities = 69/318 (21%), Positives = 123/318 (38%), Gaps = 28/318 (8%)
Query: 158 SGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGEND 217
+G + LD + V+ G CL + + ++ + DG + WD + G
Sbjct: 1697 NGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDT----LFLTAFDGLLELWDLQHGCR- 1751
Query: 218 SFAGKGHTNQVSRMTVDESGQLISC-------SMDDTVRYTSLMLRDYSGQGVVKLDVQP 270
K H Q++ + +L++ + DTVR Y + + + P
Sbjct: 1752 VLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYP-KSLNCVAFHP 1810
Query: 271 KCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVR 330
+ + G +A + Q+ LK + + PG +A + G VA+G +D V
Sbjct: 1811 EGQVIATGSWAGSISFFQVDGLKVTK---DLGAPGASIRTLAFNVPGGVVAVGRLDSMVE 1867
Query: 331 LYSILGTTLKDEGKLLEA----KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENN 386
L++ EG L A G V + H G L V V+S + G +
Sbjct: 1868 LWAWR------EGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGH 1921
Query: 387 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLD 446
+ + + +A SPD + A G + ++ +S + Q VS+LAWL
Sbjct: 1922 LGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVA--VSALAWLS 1979
Query: 447 EHTLVTTSHDASVKEWTI 464
LV+ + D S++ W +
Sbjct: 1980 PKVLVSGAEDGSLQGWAL 1997
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 67.4 bits (163), Expect = 3e-11
Identities = 37/103 (35%), Positives = 53/103 (51%), Gaps = 5/103 (4%)
Query: 30 NNFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGG 89
N F GK +L ++ H+ + + FSPD TAS DG I IYD + L G
Sbjct: 173 NIFDIATGK--LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSG 230
Query: 90 SKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF 132
H + +++ PD TH +S+S DK+ K+WDV + V TF
Sbjct: 231 ---HASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 7/167 (4%)
Query: 44 NIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWS 103
++D +F+ + +SPDG A+ + DG I I+D TG+ + L G H I ++++S
Sbjct: 143 SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEG---HAMPIRSLTFS 199
Query: 104 PDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINY 163
PDS L++AS D KI+DV ++ T ++ + C H +S S +
Sbjct: 200 PDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCP-DDTHFVSSSSDKSVKV 258
Query: 164 LDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWD 210
D + +H H Q V NG S I S D I+ +D
Sbjct: 259 WDVGTRT-CVHTFFDHQD--QVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 53.5 bits (127), Expect = 4e-07
Identities = 58/246 (23%), Positives = 103/246 (41%), Gaps = 28/246 (11%)
Query: 189 HKNGGKSYIYSGSHDGHINYWDSETGEND-SFAGKGHTNQVSRMTVDESGQL---ISCSM 244
+K + +GS D + W D ++ +GH Q+ ++VD S L S S+
Sbjct: 27 NKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGH--QLGVVSVDISHTLPIAASSSL 84
Query: 245 DDTVRYTSLMLRDYSGQGVVKLDVQPK---CVAVGPGGY--AVVVCIGQIVL--LKDQRK 297
D +R L +G+ + +D P +A P A +G++ + ++ +K
Sbjct: 85 DAHIRLWDLE----NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKK 140
Query: 298 CFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKG----PVT 353
+S+D G +A P G +A G +DG + ++ I GKLL P+
Sbjct: 141 EYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIA------TGKLLHTLEGHAMPIR 194
Query: 354 DVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMD 413
+ +S D L + ++ V + GH + ++ +A+ PD+ HF S D
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFCPDDTHFVSSSSD 253
Query: 414 MMVYVW 419
V VW
Sbjct: 254 KSVKVW 259
Score = 46.2 bits (108), Expect = 6e-05
Identities = 41/177 (23%), Positives = 78/177 (44%), Gaps = 12/177 (6%)
Query: 292 LKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKL---LEA 348
L++ ++ SID + +A P +A G G V ++ + + GK L+
Sbjct: 93 LENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV------ESGKKEYSLDT 146
Query: 349 KGP-VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHF 407
+G + +AYS DG +LA ++ +F +A G + + GH I L +SPD++
Sbjct: 147 RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTL-EGHAMPIRSLTFSPDSQLL 205
Query: 408 ASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
+ D + ++ + + H ++ D+ V++S D SVK W +
Sbjct: 206 VTASDDGYIKIYDVQHANLAGTLS-GHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 45.4 bits (106), Expect = 1e-04
Identities = 45/178 (25%), Positives = 79/178 (44%), Gaps = 9/178 (5%)
Query: 36 NGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDG 95
NGK + ++ID + FSPD AT + G++ I+ ++G+K +L
Sbjct: 95 NGKQI--KSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSL---DTRGK 149
Query: 96 GIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSV 155
I +I++SPD +L S + D I+D++ ++ T G + + L L++
Sbjct: 150 FILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTA 208
Query: 156 SLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
S GYI D + + + GH+ + L V ++ S S D + WD T
Sbjct: 209 SDDGYIKIYDVQH-ANLAGTLSGHASWV--LNVAFCPDDTHFVSSSSDKSVKVWDVGT 263
Score = 42.7 bits (99), Expect = 7e-04
Identities = 37/150 (24%), Positives = 72/150 (48%), Gaps = 12/150 (8%)
Query: 321 AIGGVDGNVRLYSILGTTLKDEGKLLEA--KGPVT--DVAYSHDGAFLAVCDASKVVTVF 376
A +D ++RL+ + + GK +++ GPV +A+S D +LA V +F
Sbjct: 80 ASSSLDAHIRLWDL------ENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133
Query: 377 SVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRL 436
V G E ++ I+ +A+SPD ++ ASG +D ++ ++ ++ + + + H +
Sbjct: 134 GVESGKKEYSLDT-RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKL-LHTLEGHAM 191
Query: 437 HHVSSLAWLDEHTLVTTSHDASVKEWTITY 466
S D LVT S D +K + + +
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQH 221
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 66.2 bits (160), Expect = 6e-11
Identities = 75/309 (24%), Positives = 124/309 (40%), Gaps = 42/309 (13%)
Query: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGE-----KVCALGGSKAHDGGIYAISWSPDS 106
V C RFSPDG T S DG I +++ TG+ K A D + + +S D+
Sbjct: 217 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 276
Query: 107 THLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDR 166
L + + D K+W + + F + L +LS S I +
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIR-IHG 335
Query: 167 NNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE-NDSFAGKGHT 225
K L +GHS + T ++G YI S S DG + W+ +T E +++F G T
Sbjct: 336 LKSGKTLKEFRGHSSFVNEATFTQDG--HYIISASSDGTVKIWNMKTTECSNTFKSLGST 393
Query: 226 -------NQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPK------C 272
N V + + + C+ +TV ++ + GQ V + C
Sbjct: 394 AGTDITVNSVILLPKNPE-HFVVCNRSNTV-----VIMNMQGQIVRSFSSGKREGGDFVC 447
Query: 273 VAVGPGGYAVVVCIGQIVLLKDQRKCFSIDN-------PGYEPEVVAV--HPGGDTVAIG 323
A+ P G + C+G+ +L CFS +E +V+ + HP + +A
Sbjct: 448 CALSPRG-EWIYCVGEDFVL----YCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATY 502
Query: 324 GVDGNVRLY 332
DG ++L+
Sbjct: 503 SEDGLLKLW 511
Score = 52.0 bits (123), Expect = 1e-06
Identities = 34/104 (32%), Positives = 57/104 (54%), Gaps = 7/104 (6%)
Query: 36 NGKCVILRNIDD-HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 94
+G+C LR + HS+ V C+ FS D ++ +AS D I I+ K+G+ L + H
Sbjct: 295 SGQC--LRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGK---TLKEFRGHS 349
Query: 95 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF-PMGST 137
+ +++ D +++SAS D T KIW++ +TF +GST
Sbjct: 350 SFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGST 393
Score = 43.5 bits (101), Expect = 4e-04
Identities = 34/162 (20%), Positives = 61/162 (37%), Gaps = 7/162 (4%)
Query: 309 EVVAVHPGGDTVAIGGVDGNVRLYSIL-GTTLKD-----EGKLLEAKGPVTDVAYSHDGA 362
E P G + G VDG + +++ G KD + + V + +S D
Sbjct: 218 ECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE 277
Query: 363 FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLS 422
LA + V+ + G H + CL++S D+ S D + + L
Sbjct: 278 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 337
Query: 423 DPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
+T + + H + D H +++ S D +VK W +
Sbjct: 338 SGKTLKEFR-GHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Score = 36.6 bits (83), Expect = 0.050
Identities = 39/173 (22%), Positives = 72/173 (41%), Gaps = 8/173 (4%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE---KVCALGGSKAHDGGIY 98
L+ HS FVN F+ DG+ +AS+DG + I++ KT E +LG + D +
Sbjct: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVN 401
Query: 99 AISWSP-DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGC-LWQKDHLLSVS 156
++ P + H + + T I ++ +V +F G + C L + +
Sbjct: 402 SVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDFVCCALSPRGEWIYCV 460
Query: 157 LSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW 209
++ Y K + H K + + H + ++ I + S DG + W
Sbjct: 461 GEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPH--QNLIATYSEDGLLKLW 511
Score = 35.8 bits (81), Expect = 0.085
Identities = 20/86 (23%), Positives = 38/86 (44%), Gaps = 7/86 (8%)
Query: 386 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETR----VKIQDAHRLHHVSS 441
++ +G + + C +SPD ++ +G +D + VW + + R + QD + +
Sbjct: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
Query: 442 LAWL---DEHTLVTTSHDASVKEWTI 464
L D L T + D +K W I
Sbjct: 268 LCMCFSRDTEMLATGAQDGKIKVWKI 293
Score = 35.4 bits (80), Expect = 0.11
Identities = 24/119 (20%), Positives = 46/119 (38%), Gaps = 7/119 (5%)
Query: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADG-------YSENNVFYGHHAKIVCLAWS 401
K V +S DG +L + V++ G Y + F ++C+ +S
Sbjct: 214 KSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFS 273
Query: 402 PDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 460
D E A+G D + VW + + + + AH D +++ S D +++
Sbjct: 274 RDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 332
Score = 32.3 bits (72), Expect = 0.94
Identities = 21/108 (19%), Positives = 46/108 (42%), Gaps = 2/108 (1%)
Query: 318 DTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFS 377
+ +A G DG ++++ I + +KG VT +++S D + + + + +
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG-VTCLSFSKDSSQILSASFDQTIRIHG 335
Query: 378 VADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPE 425
+ G + F GH + + ++ D + S D V +W + E
Sbjct: 336 LKSGKTLKE-FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 65.5 bits (158), Expect = 1e-10
Identities = 50/187 (26%), Positives = 79/187 (42%), Gaps = 33/187 (17%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L + H+ V RFSPDG+ FA+AS D + ++D + + L K H + +
Sbjct: 55 LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL---KGHQRSVETV 111
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 160
S+SPDS L S DK +WDV ++ + +D + S S
Sbjct: 112 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL-------------VGHRDSIQSSDFSPT 158
Query: 161 INYLDRNNPSKPLHV--------------IKGHSKSIQCLTVHKNGGKSYIYSGSHDGHI 206
+N L + +H+ ++GHS +I CL +G + SGS D I
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTI 215
Query: 207 NYWDSET 213
+ W T
Sbjct: 216 HIWKPTT 222
Score = 64.3 bits (155), Expect = 2e-10
Identities = 68/254 (26%), Positives = 103/254 (40%), Gaps = 33/254 (12%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H VN FSPDG T S DG +Y ++ ++G+ + LGG H G + +SPD
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGG---HTGPVKFCRFSPDGH 76
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLD---------QQLGCLWQKDHLLSVSLS 158
SAS D T ++WDV+ + ++ Q W K +L S
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQS 136
Query: 159 GYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSE--TGEN 216
G + L ++ GH SIQ + + +GS D ++ WD T
Sbjct: 137 GQM-----------LRLLVGHRDSIQSSDFSPT--VNCLATGSWDSTVHIWDLRMVTPAV 183
Query: 217 DSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRY----TSLMLRDYSGQ--GVVKLDVQP 270
A +GH+ +S + SG L S S D T+ TS +L G V + P
Sbjct: 184 SHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP 243
Query: 271 KCVAVGPGGYAVVV 284
+ + GY+ +V
Sbjct: 244 DELWLASAGYSRMV 257
Score = 52.4 bits (124), Expect = 9e-07
Identities = 51/209 (24%), Positives = 85/209 (40%), Gaps = 17/209 (8%)
Query: 18 GVSKIIGGDPKGNNFLYTNGKCVI----------LRNIDDHSRFVNCVRFSPDGNRFATA 67
G K P G+ F + C + LR + H R V V FSPD + A+
Sbjct: 64 GPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 68 SADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDV-SVN 126
D ++ ++D ++G+ + L G H I + +SP L + S D T IWD+ V
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVG---HRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
Query: 127 SVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCL 186
VS + + C L S S I ++ + S L +KGH ++ +
Sbjct: 181 PAVSHQALEGHSANISCLCYSASGLLASGSWDKTI-HIWKPTTSSLLIQLKGHVTWVKSI 239
Query: 187 TVHKNGGKSYIYSGSHDGHINYWDSETGE 215
+ + ++ S + + WD TG+
Sbjct: 240 AFSPD--ELWLASAGYSRMVKVWDCNTGK 266
Score = 46.6 bits (109), Expect = 5e-05
Identities = 44/160 (27%), Positives = 65/160 (40%), Gaps = 4/160 (2%)
Query: 305 GYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFL 364
G E A P G + G DG V + L +L GPV +S DG
Sbjct: 21 GGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLL--WRLGGHTGPVKFCRFSPDGHLF 78
Query: 365 AVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDP 424
A V ++ VA V GH + +++SPD+ ASGG D V +W +
Sbjct: 79 ASASCDCTVRLWDVARAKCLR-VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 425 ETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
+ +++ HR SS + L T S D++V W +
Sbjct: 138 Q-MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 43.5 bits (101), Expect = 4e-04
Identities = 32/112 (28%), Positives = 52/112 (46%), Gaps = 7/112 (6%)
Query: 45 IDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSP 104
++ HS ++C+ +S G A+ S D I+I+ T + L K H + +I++SP
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---KGHVTWVKSIAFSP 243
Query: 105 DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 156
D L SA + K+WD + + T VLD C + D + VS
Sbjct: 244 DELWLASAGYSRMVKVWDCNTGKCLETL---KGVLDVAHTCAFTPDGKILVS 292
Score = 42.4 bits (98), Expect = 0.001
Identities = 63/237 (26%), Positives = 95/237 (40%), Gaps = 26/237 (10%)
Query: 197 IYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLM- 254
+ +GS DG + W++ +G+ G GHT V G L S S D TVR +
Sbjct: 36 LLTGSEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR 94
Query: 255 ---LRDYSG--QGVVKLDVQPKCVAVGPGGYAVVVCI-----GQIV-LLKDQRKCFSIDN 303
LR G + V + P + GG+ V + GQ++ LL R SI +
Sbjct: 95 AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD--SIQS 152
Query: 304 PGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP-VTDVAYSHDGA 362
+ P V + +A G D V ++ + T + LE ++ + YS G
Sbjct: 153 SDFSPTV-------NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG- 204
Query: 363 FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
LA K + ++ S GH + +A+SPD AS G MV VW
Sbjct: 205 LLASGSWDKTIHIWKPTTS-SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 260
Score = 32.3 bits (72), Expect = 0.94
Identities = 22/81 (27%), Positives = 39/81 (48%), Gaps = 7/81 (8%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGG--SKAHDGGIY 98
+L + H +V + FSPD A+A + ++D TG+ + L G AH
Sbjct: 225 LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAH----- 279
Query: 99 AISWSPDSTHLLSASGDKTSK 119
+++PD L+S + D+T +
Sbjct: 280 TCAFTPDGKILVSGAADQTRR 300
>gi|55743075 angio-associated, migratory cell protein [Homo sapiens]
Length = 434
Score = 65.1 bits (157), Expect = 1e-10
Identities = 58/241 (24%), Positives = 99/241 (41%), Gaps = 24/241 (9%)
Query: 22 IIGGDPKGNNFLYT--NGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGK 79
++ G GN +++ NG C + + C R PDG R DG I I+D K
Sbjct: 189 LLAGTADGNTWMWKVPNGDC---KTFQGPNCPATCGRVLPDGKRAVVGYEDGTIRIWDLK 245
Query: 80 TGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVL 139
G + L G++ H G + ++ + D + +L+ S D +K+ + VV F +
Sbjct: 246 QGSPIHVLKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVSATTGKVVGVFRPETVAS 305
Query: 140 DQQLGCLWQKDHLLSVSLSGY--------INYLDRNNPSKPL------HVIKGHSKSIQC 185
LG ++ SV G+ + YLD L H + S +Q
Sbjct: 306 QPSLG-EGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLATQTLRHQCQHQSGIVQL 364
Query: 186 LTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMD 245
L G + +Y+ S DG + WD+ TG + +GHT ++ + + L+ +
Sbjct: 365 LW---EAGTAVVYTCSLDGIVRLWDARTGRLLT-DYRGHTAEILDFALSKDASLVVTTSG 420
Query: 246 D 246
D
Sbjct: 421 D 421
Score = 54.3 bits (129), Expect = 2e-07
Identities = 86/389 (22%), Positives = 155/389 (39%), Gaps = 56/389 (14%)
Query: 48 HSRFVNCVRFSPDGNRFA-TASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
HS V CV P N A T D + +++ GE + G H + +S DS
Sbjct: 90 HSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGELLFECAG---HKDSVTCAGFSHDS 146
Query: 107 THLLSASGDKTS--KIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDH-----LLSVSLSG 159
T L A+GD + K+W V V +F G W + H LL+ + G
Sbjct: 147 T--LVATGDMSGLLKVWQVDTKEEVWSFEAGDLE--------WMEWHPRAPVLLAGTADG 196
Query: 160 YINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--ND 217
N P+ +G + C V +G ++ + G DG I WD + G +
Sbjct: 197 --NTWMWKVPNGDCKTFQGPNCPATCGRVLPDGKRAVV--GYEDGTIRIWDLKQGSPIHV 252
Query: 218 SFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVG 276
+GH ++ + ++ G LI + S+D + S + G V +P+ VA
Sbjct: 253 LKGTEGHQGPLTCVAANQDGSLILTGSVDCQAKLVS------ATTGKVVGVFRPETVASQ 306
Query: 277 PGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILG 336
P +G+ ++ + S+++ G+ +V P A+G +DG + +Y +
Sbjct: 307 PS-------LGE----GEESESNSVESLGF----CSVMP---LAAVGYLDGTLAIYDLAT 348
Query: 337 TTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIV 396
TL+ + + + + + + A + C +V ++ G + + GH A+I+
Sbjct: 349 QTLRHQ---CQHQSGIVQLLWEAGTAVVYTCSLDGIVRLWDARTGRLLTD-YRGHTAEIL 404
Query: 397 CLAWSPDNEHFASGGMDMMVYVWTLSDPE 425
A S D + D V+ + P+
Sbjct: 405 DFALSKDASLVVTTSGDHKAKVFCVQRPD 433
Score = 32.0 bits (71), Expect = 1.2
Identities = 24/88 (27%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 380 DGYSENNVFYG-HHAKIVCLAWSPDNEHFA-SGGMDMMVYVWTLSDPETRVKIQDAHRLH 437
+G ++ V + H A + C++ P A +GG D +VW LSD E + + A
Sbjct: 78 EGPDDSEVTFALHSASVFCVSLDPKTNTLAVTGGEDDKAFVWRLSDGE--LLFECAGHKD 135
Query: 438 HVSSLAWLDEHTLVTTSH-DASVKEWTI 464
V+ + + TLV T +K W +
Sbjct: 136 SVTCAGFSHDSTLVATGDMSGLLKVWQV 163
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 64.3 bits (155), Expect = 2e-10
Identities = 45/174 (25%), Positives = 77/174 (44%), Gaps = 7/174 (4%)
Query: 37 GKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGG 96
G C + HS V + ++ DG+ +AS D + ++D +TGE+V L G +
Sbjct: 97 GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNS 156
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVS 156
Y P + + S D T K+WD+ + + TF VL D ++S
Sbjct: 157 CYPARRGPQL--VCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND--TSDQIISGG 212
Query: 157 LSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWD 210
+ I D +K + ++GH+ S+ L++ G SY+ S + D + WD
Sbjct: 213 IDNDIKVWDLRQ-NKLTYTMRGHADSVTGLSLSSEG--SYLLSNAMDNTVRVWD 263
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/208 (24%), Positives = 87/208 (41%), Gaps = 12/208 (5%)
Query: 45 IDDHSRFVNCVRFSPDGNRFATASADGQIYIYD--GKTGEKVCALGGSKAHDGGIYAISW 102
+ H V C +F P+G+ A+A D I +++ G K H G + + +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL----KGHSGAVMELHY 117
Query: 103 SPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYIN 162
+ D + L SAS DKT +WD V ++ ++ + + S G +
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
Query: 163 YLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK 222
D + I+ + Q L V N I SG D I WD + ++ +
Sbjct: 178 LWDIRKKA----AIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTMR 232
Query: 223 GHTNQVSRMTVDESGQ-LISCSMDDTVR 249
GH + V+ +++ G L+S +MD+TVR
Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVR 260
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/335 (21%), Positives = 120/335 (35%), Gaps = 95/335 (28%)
Query: 93 HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHL 152
H+G +Y + P+ + L SA D+ +W+V
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNV----------------------------- 95
Query: 153 LSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSE 212
Y D +N + +KGHS ++ + +H N S ++S S D + WDSE
Sbjct: 96 ----------YGDCDNYA----TLKGHSGAV--MELHYNTDGSMLFSASTDKTVAVWDSE 139
Query: 213 TGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKL-DVQPK 271
TGE KGHT+ V+ G + C+ D G VKL D++ K
Sbjct: 140 TGERVKRL-KGHTSFVNSCYPARRGPQLVCTGSD--------------DGTVKLWDIRKK 184
Query: 272 CVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRL 331
Y+ V + D + GG+D ++++
Sbjct: 185 A-------------------------AIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKV 219
Query: 332 YSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSEN---NVF 388
+ + L + VT ++ S +G++L V V+ V + +F
Sbjct: 220 WDLRQNKL--TYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 389 YGH----HAKIVCLAWSPDNEHFASGGMDMMVYVW 419
G+ ++ +WSPD A+G D VYVW
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
Score = 36.6 bits (83), Expect = 0.050
Identities = 41/193 (21%), Positives = 77/193 (39%), Gaps = 12/193 (6%)
Query: 17 RGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIY 76
RG + G G L+ K ++ + + V V F+ ++ + D I ++
Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVW 220
Query: 77 DGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDV----SVNSVVSTF 132
D + + + G H + +S S + ++LLS + D T ++WDV V F
Sbjct: 221 DLRQNKLTYTMRG---HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF 277
Query: 133 PMGSTVLDQQ-LGCLWQKD-HLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHK 190
++ L C W D ++ + Y+ + L+ + GH+ SI + H
Sbjct: 278 QGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP 337
Query: 191 NGGKSYIYSGSHD 203
+ + I S S D
Sbjct: 338 D--EPIIISASSD 348
Score = 30.0 bits (66), Expect = 4.7
Identities = 9/32 (28%), Positives = 17/32 (53%)
Query: 390 GHHAKIVCLAWSPDNEHFASGGMDMMVYVWTL 421
GH ++ C + P+ AS G D ++ +W +
Sbjct: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNV 95
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 40 VILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGI-- 97
V+ ++ H V + FSP R A+ SADG + I+D + C A + G+
Sbjct: 542 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 601
Query: 98 YAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF----PMGSTVLDQQLGCLWQKDHLL 153
S + H++++ + ++D+ V S + T G T ++Q + Q +
Sbjct: 602 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 661
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW--DS 211
+ G I +LD N KP+H + H ++ CL V NG +++ SGSHD + W D+
Sbjct: 662 AHDDRG-IRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNG--AFLMSGSHDCSLRLWSLDN 717
Query: 212 ETGENDSFA-GKGHTNQVSRMTVDESGQLISCSMDDTV 248
+T + A K H + + S LI+ + D +
Sbjct: 718 KTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADAL 755
Score = 48.5 bits (114), Expect = 1e-05
Identities = 85/374 (22%), Positives = 130/374 (34%), Gaps = 102/374 (27%)
Query: 91 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKD 150
++H GI ++++ + LL+AS D T K+W++ Q +K+
Sbjct: 442 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNL------------------QKAVTAKKN 483
Query: 151 HLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWD 210
L V +P+H + H + L V Y YSG D I+ W
Sbjct: 484 AALDV---------------EPIHAFRAHRGPV--LAVAMGSNSEYCYSGGADACIHSWK 526
Query: 211 SETGENDSFAG----------KGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 259
D + G +GH + V + + Q L SCS D TVR + D S
Sbjct: 527 IPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVR-----IWDPS 581
Query: 260 GQGVVKLDVQPKCVAVGPGG--YAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGG 317
P C+ P + V + F+ P + +VA G
Sbjct: 582 SSS-------PACLCTFPTASEHGVPTSVA-----------FTSTEPAH---IVASFRSG 620
Query: 318 DTVAIGGVDGNVRLYSILGTTLKDEGK---------LLEAKGPVTDVAYSHDGAFLAVCD 368
DTV G+ L TL+ G + P+T A HD + D
Sbjct: 621 DTVLYDMEVGSALL------TLESRGSSGPTQINQVVSHPNQPLTITA--HDDRGIRFLD 672
Query: 369 ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRV 428
V S+ H + CLA P+ SG D + +W+L D +T V
Sbjct: 673 NRTGKPVHSMV----------AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL-DNKTCV 721
Query: 429 KIQDAHRLHHVSSL 442
+ AHR H ++
Sbjct: 722 QEITAHRKKHEEAI 735
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/218 (25%), Positives = 98/218 (44%), Gaps = 13/218 (5%)
Query: 40 VILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGI-- 97
V+ ++ H V + FSP R A+ SADG + I+D + C A + G+
Sbjct: 535 VLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPT 594
Query: 98 YAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF----PMGSTVLDQQLGCLWQKDHLL 153
S + H++++ + ++D+ V S + T G T ++Q + Q +
Sbjct: 595 SVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTIT 654
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW--DS 211
+ G I +LD N KP+H + H ++ CL V NG +++ SGSHD + W D+
Sbjct: 655 AHDDRG-IRFLD-NRTGKPVHSMVAHLDAVTCLAVDPNG--AFLMSGSHDCSLRLWSLDN 710
Query: 212 ETGENDSFA-GKGHTNQVSRMTVDESGQLISCSMDDTV 248
+T + A K H + + S LI+ + D +
Sbjct: 711 KTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADAL 748
Score = 48.5 bits (114), Expect = 1e-05
Identities = 85/374 (22%), Positives = 130/374 (34%), Gaps = 102/374 (27%)
Query: 91 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKD 150
++H GI ++++ + LL+AS D T K+W++ Q +K+
Sbjct: 435 RSHYDGIRSLAFHHSQSALLTASEDGTLKLWNL------------------QKAVTAKKN 476
Query: 151 HLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWD 210
L V +P+H + H + L V Y YSG D I+ W
Sbjct: 477 AALDV---------------EPIHAFRAHRGPV--LAVAMGSNSEYCYSGGADACIHSWK 519
Query: 211 SETGENDSFAG----------KGHTNQVSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYS 259
D + G +GH + V + + Q L SCS D TVR + D S
Sbjct: 520 IPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVR-----IWDPS 574
Query: 260 GQGVVKLDVQPKCVAVGPGG--YAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGG 317
P C+ P + V + F+ P + +VA G
Sbjct: 575 SSS-------PACLCTFPTASEHGVPTSVA-----------FTSTEPAH---IVASFRSG 613
Query: 318 DTVAIGGVDGNVRLYSILGTTLKDEGK---------LLEAKGPVTDVAYSHDGAFLAVCD 368
DTV G+ L TL+ G + P+T A HD + D
Sbjct: 614 DTVLYDMEVGSALL------TLESRGSSGPTQINQVVSHPNQPLTITA--HDDRGIRFLD 665
Query: 369 ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRV 428
V S+ H + CLA P+ SG D + +W+L D +T V
Sbjct: 666 NRTGKPVHSMV----------AHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSL-DNKTCV 714
Query: 429 KIQDAHRLHHVSSL 442
+ AHR H ++
Sbjct: 715 QEITAHRKKHEEAI 728
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 63.5 bits (153), Expect = 4e-10
Identities = 83/370 (22%), Positives = 143/370 (38%), Gaps = 59/370 (15%)
Query: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
V +F N T + D QI +++ T E+V +AH I I+ P +L+
Sbjct: 60 VRAAKFVARKNWVVTGADDMQIRVFNYNTLERVHMF---EAHSDYIRCIAVHPTQPFILT 116
Query: 112 ASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDH--LLSVSLSGYINYLDRNNP 169
+S D K+WD S G T Q+ + KD+ S SL I +
Sbjct: 117 SSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQI-VINPKDNNQFASASLDRTIKVWQLGS- 174
Query: 170 SKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVS 229
S P ++GH K + C+ + G K Y+ SG+ D + WD + + +GH VS
Sbjct: 175 SSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQ-NKTCVQTLEGHAQNVS 233
Query: 230 RMTV-DESGQLISCSMDDTVRY----------------------------TSLMLRDYSG 260
+ E +I+ S D TVR ++ L G
Sbjct: 234 CASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEG 293
Query: 261 QGVVKLDVQPKCVAVGPGG-----------YAVVVCIGQIVLLKDQRKCFSIDNPG---Y 306
+VKL + +++ G A + +G + +R ++ + G
Sbjct: 294 SIIVKLGREEPAMSMDANGKIIWAKHSEVQQANLKAMGDAEIKDGERLPLAVKDMGSCEI 353
Query: 307 EPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 366
P+ + +P G V + G DG +Y+ + K G E A++HD + A+
Sbjct: 354 YPQTIQHNPNGRFVVVCG-DGEYIIYTAMALRNKSFGSAQE-------FAWAHDSSEYAI 405
Query: 367 CDASKVVTVF 376
+++ +V +F
Sbjct: 406 RESNSIVKIF 415
Score = 33.9 bits (76), Expect = 0.32
Identities = 21/83 (25%), Positives = 40/83 (48%), Gaps = 2/83 (2%)
Query: 382 YSENNVFYGHHAKIVCLAWSP-DNEHFASGGMDMMVYVWTLSDPETRVKIQDAHR-LHHV 439
+S + VF GH ++ + +P DN FAS +D + VW L ++ + ++ +
Sbjct: 132 WSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCI 191
Query: 440 SSLAWLDEHTLVTTSHDASVKEW 462
+ D+ L++ + D VK W
Sbjct: 192 DYYSGGDKPYLISGADDRLVKIW 214
Score = 30.4 bits (67), Expect = 3.6
Identities = 15/47 (31%), Positives = 24/47 (51%), Gaps = 2/47 (4%)
Query: 34 YTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKT 80
Y N CV + ++ H++ V+C F P+ T S DG + I+ T
Sbjct: 216 YQNKTCV--QTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSST 260
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 63.2 bits (152), Expect = 5e-10
Identities = 100/475 (21%), Positives = 166/475 (34%), Gaps = 118/475 (24%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + ++S D
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCAFSTDDR 670
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN 167
+ + S DK KIW+ S++G +
Sbjct: 671 FIATCSVDKKVKIWN---------------------------------SMTGEL------ 691
Query: 168 NPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSFAGKGHT 225
+H HS+ + C + + +GS D + WD E N F GHT
Sbjct: 692 -----VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF---GHT 743
Query: 226 NQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------LDVQPKC 272
N V+ +L+ SCS D T++ + VK ++V KC
Sbjct: 744 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 803
Query: 273 VAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRL- 331
+ G ++V + L F I G E+ H ++ +
Sbjct: 804 CSWSADGARIMVAAKNKIFL------FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 857
Query: 332 ----YSILGTTLKDEGKLLEAKGP---VTDVAYSHDG-AFLA--------------VCDA 369
Y + K+ + +G V V +S DG +FL VC
Sbjct: 858 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 917
Query: 370 SKVVTVFSVADGYSENNVF---------------------YGHHAKIVCLAWSPDNEHFA 408
S V+ V + EN V Y A++ C SP ++ A
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977
Query: 409 SGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 462
G + + + L + + + Q + H+ A DE TL+++S DA ++ W
Sbjct: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA--DEKTLISSSDDAEIQVW 1030
Score = 47.4 bits (111), Expect = 3e-05
Identities = 87/415 (20%), Positives = 160/415 (38%), Gaps = 85/415 (20%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
HS C FSP + A + + +++ + KV G H ++ + +SPD +
Sbjct: 840 HSTIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGS 895
Query: 108 HLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL----SGY 160
L++S D+T ++W+ V NS V V + + DH+ + L +G
Sbjct: 896 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955
Query: 161 INYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLTVHKNG 192
I+YL D N + L ++ H K++ +
Sbjct: 956 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVW--HIQFTA 1013
Query: 193 GKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTS 252
+ + S S D I W+ + + +GH V + ++ +L+S S D TV+ +
Sbjct: 1014 DEKTLISSSDDAEIQVWNWQLDK--CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWN 1071
Query: 253 LML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR------- 296
++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1072 IITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131
Query: 297 -KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEGKLLEA 348
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1132 CSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1177
Query: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 403
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1178 -GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1228
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE--KVCA---LGGSKAHDGG 96
L + H+ V C FS D AT +G+I I++ GE +CA G+ H G
Sbjct: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVL 139
+ + +SPD L+SA G K W+V TF T L
Sbjct: 1180 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNL 1220
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 351 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 406
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 613 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 671
Query: 407 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 461
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 672 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 727
Query: 462 WTI 464
W +
Sbjct: 728 WDL 730
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/182 (24%), Positives = 67/182 (36%), Gaps = 61/182 (33%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK----VCALGGSKAH 93
KC+ LR H V R + +R + S DG + +++ TG K VC H
Sbjct: 1036 KCIFLRG---HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVC-------H 1084
Query: 94 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLL 153
G + + S D+T S S DKT+KIW D LL
Sbjct: 1085 QGTVLSCDISHDATKFSSTSADKTAKIWSF--------------------------DLLL 1118
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
PLH ++GH+ ++C + + + +G +G I W+
Sbjct: 1119 ------------------PLHELRGHNGCVRCSAFSVD--STLLATGDDNGEIRIWNVSN 1158
Query: 214 GE 215
GE
Sbjct: 1159 GE 1160
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
++ D+HS VNC F+ + A+ ++ +K C H +
Sbjct: 691 LVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR-NTMFGHTNSVNHC 749
Query: 101 SWSPDSTHLLSASGDKTSKIWDVS 124
+SPD L S S D T K+WD +
Sbjct: 750 RFSPDDKLLASCSADGTLKLWDAT 773
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 63.2 bits (152), Expect = 5e-10
Identities = 100/475 (21%), Positives = 166/475 (34%), Gaps = 118/475 (24%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H+ V FS DG R A+ AD + ++ +TGEK+ + KAH+ + ++S D
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI---KAHEDEVLCCAFSTDDR 659
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRN 167
+ + S DK KIW+ S++G +
Sbjct: 660 FIATCSVDKKVKIWN---------------------------------SMTGEL------ 680
Query: 168 NPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE--NDSFAGKGHT 225
+H HS+ + C + + +GS D + WD E N F GHT
Sbjct: 681 -----VHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF---GHT 732
Query: 226 NQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRDYSGQGVVK------------LDVQPKC 272
N V+ +L+ SCS D T++ + VK ++V KC
Sbjct: 733 NSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKC 792
Query: 273 VAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRL- 331
+ G ++V + L F I G E+ H ++ +
Sbjct: 793 CSWSADGARIMVAAKNKIFL------FDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 846
Query: 332 ----YSILGTTLKDEGKLLEAKGP---VTDVAYSHDG-AFLA--------------VCDA 369
Y + K+ + +G V V +S DG +FL VC
Sbjct: 847 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 906
Query: 370 SKVVTVFSVADGYSENNVF---------------------YGHHAKIVCLAWSPDNEHFA 408
S V+ V + EN V Y A++ C SP ++ A
Sbjct: 907 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 966
Query: 409 SGGMDMMVYVWTLSDPET-RVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEW 462
G + + + L + + + Q + H+ A DE TL+++S DA ++ W
Sbjct: 967 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTA--DEKTLISSSDDAEIQVW 1019
Score = 47.4 bits (111), Expect = 3e-05
Identities = 87/415 (20%), Positives = 160/415 (38%), Gaps = 85/415 (20%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
HS C FSP + A + + +++ + KV G H ++ + +SPD +
Sbjct: 829 HSTIQYC-DFSPQNHLAVVALSQYCVELWNTDSRSKVADCRG---HLSWVHGVMFSPDGS 884
Query: 108 HLLSASGDKTSKIWD---VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSL----SGY 160
L++S D+T ++W+ V NS V V + + DH+ + L +G
Sbjct: 885 SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944
Query: 161 INYL--------------------DRNNPSKPLHVIKG--------HSKSIQCLTVHKNG 192
I+YL D N + L ++ H K++ +
Sbjct: 945 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVW--HIQFTA 1002
Query: 193 GKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTS 252
+ + S S D I W+ + + +GH V + ++ +L+S S D TV+ +
Sbjct: 1003 DEKTLISSSDDAEIQVWNWQLDK--CIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWN 1060
Query: 253 LML----RDY-SGQG-VVKLDVQ---PKCVAVGPGGYAVVVCIGQIVLLKDQR------- 296
++ +D+ QG V+ D+ K + A + ++ L + R
Sbjct: 1061 IITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1120
Query: 297 -KCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSI-------LGTTLKDEGKLLEA 348
FS+D+ +A G +G +R++++ L L +EG
Sbjct: 1121 CSAFSVDS--------------TLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1166
Query: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPD 403
G VTD+ +S DG L A + ++V G S + FY + + + SPD
Sbjct: 1167 -GWVTDLCFSPDGKML--ISAGGYIKWWNVVTGES-SQTFYTNGTNLKKIHVSPD 1217
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGE--KVCA---LGGSKAHDGG 96
L + H+ V C FS D AT +G+I I++ GE +CA G+ H G
Sbjct: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
Query: 97 IYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVL 139
+ + +SPD L+SA G K W+V TF T L
Sbjct: 1169 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNL 1209
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/123 (29%), Positives = 50/123 (40%), Gaps = 14/123 (11%)
Query: 351 PVTDVAY----SHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH 406
P TD Y S DG +A C A K + VF G + H +++C A+S D+
Sbjct: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRF 660
Query: 407 FASGGMDMMVYVWTLSDPETRVKIQDAHR-----LHHVSSLAWLDEHTLVTTSHDASVKE 461
A+ +D V +W E V D H H +S L L T S D +K
Sbjct: 661 IATCSVDKKVKIWNSMTGEL-VHTYDEHSEQVNCCHFTNSSHHL---LLATGSSDCFLKL 716
Query: 462 WTI 464
W +
Sbjct: 717 WDL 719
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/182 (24%), Positives = 67/182 (36%), Gaps = 61/182 (33%)
Query: 38 KCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK----VCALGGSKAH 93
KC+ LR H V R + +R + S DG + +++ TG K VC H
Sbjct: 1025 KCIFLRG---HQETVKDFRLLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVC-------H 1073
Query: 94 DGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLL 153
G + + S D+T S S DKT+KIW D LL
Sbjct: 1074 QGTVLSCDISHDATKFSSTSADKTAKIWSF--------------------------DLLL 1107
Query: 154 SVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSET 213
PLH ++GH+ ++C + + + +G +G I W+
Sbjct: 1108 ------------------PLHELRGHNGCVRCSAFSVD--STLLATGDDNGEIRIWNVSN 1147
Query: 214 GE 215
GE
Sbjct: 1148 GE 1149
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
++ D+HS VNC F+ + A+ ++ +K C H +
Sbjct: 680 LVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR-NTMFGHTNSVNHC 738
Query: 101 SWSPDSTHLLSASGDKTSKIWDVS 124
+SPD L S S D T K+WD +
Sbjct: 739 RFSPDDKLLASCSADGTLKLWDAT 762
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 63.2 bits (152), Expect = 5e-10
Identities = 55/216 (25%), Positives = 90/216 (41%), Gaps = 21/216 (9%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L + H+ V +RFS T S D I ++D + + H + +
Sbjct: 312 VLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 369
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 160
+ D +++SASGD+T K+W S V T + + CL +D L+ S
Sbjct: 370 DF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRGIACLQYRDRLVVSGSSDN 423
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
L L V++GH + ++C+ I SG++DG I WD + +
Sbjct: 424 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 479
Query: 221 GK--------GHTNQVSRMTVDESGQLISCSMDDTV 248
H+ +V R+ DE Q+IS S DDT+
Sbjct: 480 ASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 514
Score = 39.3 bits (90), Expect = 0.008
Identities = 44/208 (21%), Positives = 79/208 (37%), Gaps = 52/208 (25%)
Query: 47 DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
++S+ V C+++ D + + D I I+D + E + L G H G + + + D
Sbjct: 238 ENSKGVYCLQY--DDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQY--DE 290
Query: 107 THLLSASGDKTSKIWDVSVNSVVST------------FPMGSTVL---DQQLGCLWQKDH 151
+++ S D T ++WDV+ V++T F G V D+ + +W
Sbjct: 291 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI-AVWDMAS 349
Query: 152 LLSVSL-------SGYINYLD------------------RNNPSKPLHVIKGHSKSIQCL 186
++L +N +D + + + + GH + I CL
Sbjct: 350 ATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 409
Query: 187 TVHKNGGKSYIYSGSHDGHINYWDSETG 214
+ SGS D I WD E G
Sbjct: 410 QYRDR----LVVSGSSDNTIRLWDIECG 433
Score = 37.7 bits (86), Expect = 0.022
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 173 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 232
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 273 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 326
Query: 233 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 283
+G +++CS D D T + LR V +D K + G +
Sbjct: 327 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 386
Query: 284 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 342
V C F G++ + + V G D +RL+ I
Sbjct: 387 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 430
Query: 343 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 402
GA L V + GH + C+ +
Sbjct: 431 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 451
Query: 403 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 452
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 452 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 507
Query: 453 TSHDASVKEW 462
+SHD ++ W
Sbjct: 508 SSHDDTILIW 517
Score = 32.3 bits (72), Expect = 0.94
Identities = 20/91 (21%), Positives = 45/91 (49%), Gaps = 7/91 (7%)
Query: 33 LYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA 92
+++ C +R ++ H R + C+++ + S+D I ++D + G + L G
Sbjct: 387 VWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEG--- 441
Query: 93 HDGGIYAISWSPDSTHLLSASGDKTSKIWDV 123
H+ + I + D+ ++S + D K+WD+
Sbjct: 442 HEELVRCIRF--DNKRIVSGAYDGKIKVWDL 470
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 63.2 bits (152), Expect = 5e-10
Identities = 55/216 (25%), Positives = 90/216 (41%), Gaps = 21/216 (9%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L + H+ V +RFS T S D I ++D + + H + +
Sbjct: 278 VLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 335
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 160
+ D +++SASGD+T K+W S V T + + CL +D L+ S
Sbjct: 336 DF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRGIACLQYRDRLVVSGSSDN 389
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
L L V++GH + ++C+ I SG++DG I WD + +
Sbjct: 390 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 445
Query: 221 GK--------GHTNQVSRMTVDESGQLISCSMDDTV 248
H+ +V R+ DE Q+IS S DDT+
Sbjct: 446 ASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 480
Score = 39.3 bits (90), Expect = 0.008
Identities = 44/208 (21%), Positives = 79/208 (37%), Gaps = 52/208 (25%)
Query: 47 DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
++S+ V C+++ D + + D I I+D + E + L G H G + + + D
Sbjct: 204 ENSKGVYCLQY--DDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQY--DE 256
Query: 107 THLLSASGDKTSKIWDVSVNSVVST------------FPMGSTVL---DQQLGCLWQKDH 151
+++ S D T ++WDV+ V++T F G V D+ + +W
Sbjct: 257 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI-AVWDMAS 315
Query: 152 LLSVSL-------SGYINYLD------------------RNNPSKPLHVIKGHSKSIQCL 186
++L +N +D + + + + GH + I CL
Sbjct: 316 ATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 375
Query: 187 TVHKNGGKSYIYSGSHDGHINYWDSETG 214
+ SGS D I WD E G
Sbjct: 376 QYRDR----LVVSGSSDNTIRLWDIECG 399
Score = 37.7 bits (86), Expect = 0.022
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 173 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 232
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 239 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 292
Query: 233 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 283
+G +++CS D D T + LR V +D K + G +
Sbjct: 293 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 352
Query: 284 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 342
V C F G++ + + V G D +RL+ I
Sbjct: 353 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 396
Query: 343 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 402
GA L V + GH + C+ +
Sbjct: 397 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 417
Query: 403 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 452
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 418 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 473
Query: 453 TSHDASVKEW 462
+SHD ++ W
Sbjct: 474 SSHDDTILIW 483
Score = 32.3 bits (72), Expect = 0.94
Identities = 20/91 (21%), Positives = 45/91 (49%), Gaps = 7/91 (7%)
Query: 33 LYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA 92
+++ C +R ++ H R + C+++ + S+D I ++D + G + L G
Sbjct: 353 VWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEG--- 407
Query: 93 HDGGIYAISWSPDSTHLLSASGDKTSKIWDV 123
H+ + I + D+ ++S + D K+WD+
Sbjct: 408 HEELVRCIRF--DNKRIVSGAYDGKIKVWDL 436
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 63.2 bits (152), Expect = 5e-10
Identities = 55/216 (25%), Positives = 90/216 (41%), Gaps = 21/216 (9%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L + H+ V +RFS T S D I ++D + + H + +
Sbjct: 299 VLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 356
Query: 101 SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY 160
+ D +++SASGD+T K+W S V T + + CL +D L+ S
Sbjct: 357 DF--DDKYIVSASGDRTIKVWSTSTCEFVRTL----NGHKRGIACLQYRDRLVVSGSSDN 410
Query: 161 INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA 220
L L V++GH + ++C+ I SG++DG I WD + +
Sbjct: 411 TIRLWDIECGACLRVLEGHEELVRCIRF----DNKRIVSGAYDGKIKVWDLQAALDPRAP 466
Query: 221 GK--------GHTNQVSRMTVDESGQLISCSMDDTV 248
H+ +V R+ DE Q+IS S DDT+
Sbjct: 467 ASTLCLRTLVEHSGRVFRLQFDEF-QIISSSHDDTI 501
Score = 39.3 bits (90), Expect = 0.008
Identities = 44/208 (21%), Positives = 79/208 (37%), Gaps = 52/208 (25%)
Query: 47 DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
++S+ V C+++ D + + D I I+D + E + L G H G + + + D
Sbjct: 225 ENSKGVYCLQY--DDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQY--DE 277
Query: 107 THLLSASGDKTSKIWDVSVNSVVST------------FPMGSTVL---DQQLGCLWQKDH 151
+++ S D T ++WDV+ V++T F G V D+ + +W
Sbjct: 278 RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSI-AVWDMAS 336
Query: 152 LLSVSL-------SGYINYLD------------------RNNPSKPLHVIKGHSKSIQCL 186
++L +N +D + + + + GH + I CL
Sbjct: 337 ATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL 396
Query: 187 TVHKNGGKSYIYSGSHDGHINYWDSETG 214
+ SGS D I WD E G
Sbjct: 397 QYRDR----LVVSGSSDNTIRLWDIECG 420
Score = 37.7 bits (86), Expect = 0.022
Identities = 65/310 (20%), Positives = 103/310 (33%), Gaps = 85/310 (27%)
Query: 173 LHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMT 232
L V+ GH+ S+ CL + I +GS D + WD TGE H N+
Sbjct: 260 LKVLTGHTGSVLCLQYDER----VIVTGSSDSTVRVWDVNTGE--VLNTLIHHNEAVLHL 313
Query: 233 VDESGQLISCSMD------DTVRYTSLMLRDY---SGQGVVKLDVQPKCVAVGPGGYAVV 283
+G +++CS D D T + LR V +D K + G +
Sbjct: 314 RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIK 373
Query: 284 VCIGQIVLLKDQRKC-FSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 342
V C F G++ + + V G D +RL+ I
Sbjct: 374 VW--------STSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDI-------- 417
Query: 343 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 402
GA L V + GH + C+ +
Sbjct: 418 ----------------ECGACLRVLE---------------------GHEELVRCIRF-- 438
Query: 403 DNEHFASGGMDMMVYVWTLS---DPET-------RVKIQDAHRLHHVSSLAWLDEHTLVT 452
DN+ SG D + VW L DP R ++ + R+ + DE +++
Sbjct: 439 DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQ----FDEFQIIS 494
Query: 453 TSHDASVKEW 462
+SHD ++ W
Sbjct: 495 SSHDDTILIW 504
Score = 32.3 bits (72), Expect = 0.94
Identities = 20/91 (21%), Positives = 45/91 (49%), Gaps = 7/91 (7%)
Query: 33 LYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA 92
+++ C +R ++ H R + C+++ + S+D I ++D + G + L G
Sbjct: 374 VWSTSTCEFVRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEG--- 428
Query: 93 HDGGIYAISWSPDSTHLLSASGDKTSKIWDV 123
H+ + I + D+ ++S + D K+WD+
Sbjct: 429 HEELVRCIRF--DNKRIVSGAYDGKIKVWDL 457
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 63.2 bits (152), Expect = 5e-10
Identities = 59/249 (23%), Positives = 92/249 (36%), Gaps = 24/249 (9%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H + FSP N+FAT S DG + I+D + L G H + + W P
Sbjct: 201 HKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRG---HGADVKCVDWHPTKG 257
Query: 108 HLLSASGDKTS--KIWDVSVNSVVSTF-PMGSTVLDQQLGCLWQKDHLLSVSLSGYINYL 164
++S S D K WD ++T +TV++ +L + LL+ S
Sbjct: 258 LVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNL--NGNWLLTASRDHLCKLF 315
Query: 165 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
D N + L V +GH K + H + SG DG + +W + H
Sbjct: 316 DIRNLKEELQVFRGHKKEATAVAWHP-VHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAH 374
Query: 225 TNQVSRMTVDESGQLISCSMDDTV---------------RYTSLMLRDYSGQGVVKLDVQ 269
+ + G ++ +D RY +L S GV D++
Sbjct: 375 EGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLE 434
Query: 270 PKCVAVGPG 278
P +AV PG
Sbjct: 435 PNSLAVIPG 443
Score = 58.9 bits (141), Expect = 9e-09
Identities = 47/194 (24%), Positives = 89/194 (45%), Gaps = 12/194 (6%)
Query: 55 VRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASG 114
VR++P+G R T ++ G+ +++G T L +AHD + A++WS + +L+A
Sbjct: 125 VRWTPEGRRLVTGASSGEFTLWNGLTFNFETIL---QAHDSPVRAMTWSHNDMWMLTADH 181
Query: 115 DKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLH 174
K W ++N+V + + K + S G + D +
Sbjct: 182 GGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNK--FATCSDDGTVRIWDFLRCHEE-R 238
Query: 175 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGH--INYWDSETGENDSFAGKGHTNQVSRMT 232
+++GH ++C+ H K + SGS D I +WD +TG++ + H N V +
Sbjct: 239 ILRGHGADVKCVDWHPT--KGLVVSGSKDSQQPIKFWDPKTGQSLATL-HAHKNTVMEVK 295
Query: 233 VDESGQ-LISCSMD 245
++ +G L++ S D
Sbjct: 296 LNLNGNWLLTASRD 309
Score = 53.1 bits (126), Expect = 5e-07
Identities = 65/292 (22%), Positives = 107/292 (36%), Gaps = 47/292 (16%)
Query: 175 VIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSF-AGKGHTNQVSRMTV 233
+++ H ++ +T N ++ + H G++ YW S F A K + S
Sbjct: 156 ILQAHDSPVRAMTWSHND--MWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPT 213
Query: 234 DESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLK 293
D + +CS D TVR I +
Sbjct: 214 DN--KFATCSDDGTVR------------------------------------IWDFLRCH 235
Query: 294 DQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVT 353
++R + G + + V HP V G D + T + L K V
Sbjct: 236 EER---ILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVM 292
Query: 354 DVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEH-FASGGM 412
+V + +G +L + +F + + E VF GH + +AW P +E FASGG
Sbjct: 293 EVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGS 352
Query: 413 DMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLD-EHTLVTTSHDASVKEWT 463
D + W + + ++ AH + SLAW H L + S+D + K WT
Sbjct: 353 DGSLLFWHVGVEKEVGGMEMAHE-GMIWSLAWHPLGHILCSGSNDHTSKFWT 403
Score = 30.0 bits (66), Expect = 4.7
Identities = 30/126 (23%), Positives = 51/126 (40%), Gaps = 9/126 (7%)
Query: 344 KLLEA-KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 402
K+ +A K + + ++S A C V ++ + E + GH A + C+ W P
Sbjct: 196 KMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEER-ILRGHGADVKCVDWHP 254
Query: 403 DNEHFASGGMDMM--VYVWTLSDPETRVKIQ--DAHRLHHVSSLAWLDEHTLVTTSHDAS 458
SG D + W DP+T + AH+ + L+ + L+T S D
Sbjct: 255 TKGLVVSGSKDSQQPIKFW---DPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHL 311
Query: 459 VKEWTI 464
K + I
Sbjct: 312 CKLFDI 317
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 63.2 bits (152), Expect = 5e-10
Identities = 47/171 (27%), Positives = 80/171 (46%), Gaps = 13/171 (7%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H+ +V C +FSPDG + S D I I+D T K C S + G + ++P T
Sbjct: 143 HTHWVRCAKFSPDGRLIVSCSEDKTIKIWD--TTNKQCVNNFSDSV-GFANFVDFNPSGT 199
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLW---QKDHLLSVSLSGYINYL 164
+ SA D+T K+WDV VN ++ + + S + C+ ++L++ S G + L
Sbjct: 200 CIASAGSDQTVKVWDVRVNKLLQHYQVHS----GGVNCISFHPSGNYLITASSDGTLKIL 255
Query: 165 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGE 215
D + ++ ++GH+ + TV + G SG D + W + E
Sbjct: 256 DLLE-GRLIYTLQGHTGPV--FTVSFSKGGELFASGGADTQVLLWRTNFDE 303
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/292 (21%), Positives = 116/292 (39%), Gaps = 17/292 (5%)
Query: 178 GHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQVSRMTVDES 236
GH + + +G + + S S D + W + G+ F K HT V +
Sbjct: 58 GHKDVVTSVQFSPHG--NLLASASRDRTVRLWIPDKRGKFSEF--KAHTAPVRSVDFSAD 113
Query: 237 GQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI-GQIVLLKD- 294
GQ ++ + +D M R + + +C P G +V C + + + D
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173
Query: 295 -QRKCFS--IDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGP 351
++C + D+ G+ V +P G +A G D V+++ + L ++ G
Sbjct: 174 TNKQCVNNFSDSVGFA-NFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV--HSGG 230
Query: 352 VTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGG 411
V +++ G +L + + + + +G + GH + +++S E FASGG
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTL-QGHTGPVFTVSFSKGGELFASGG 289
Query: 412 MDMMVYVWTLSDPETRVK---IQDAHRLHHVSSLAWLDEHTLVTTSHDASVK 460
D V +W + E K ++ RLH S LD + H+ V+
Sbjct: 290 ADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVE 341
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/97 (32%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 35 TNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHD 94
TN +CV N D F N V F+P G A+A +D + ++D + + L + H
Sbjct: 174 TNKQCV--NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNK---LLQHYQVHS 228
Query: 95 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVST 131
GG+ IS+ P +L++AS D T KI D+ ++ T
Sbjct: 229 GGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT 265
Score = 54.7 bits (130), Expect = 2e-07
Identities = 54/240 (22%), Positives = 97/240 (40%), Gaps = 46/240 (19%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDST 107
H V V+FSP GN A+AS D + ++ +K KAH + ++ +S D
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLW---IPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
Query: 108 HLLSASGDKTSKIWDVSVNSVVSTF-------------PMGSTVL---DQQLGCLWQKDH 151
L +AS DK+ K+W + + + P G ++ + + +W +
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 152 LLSVS----LSGYINYLDRN--------------------NPSKPLHVIKGHSKSIQCLT 187
V+ G+ N++D N +K L + HS + C++
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
Query: 188 VHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDT 247
H +G +Y+ + S DG + D G + +GHT V ++ + G+L + DT
Sbjct: 236 FHPSG--NYLITASSDGTLKILDLLEGRL-IYTLQGHTGPVFTVSFSKGGELFASGGADT 292
Score = 50.1 bits (118), Expect = 4e-06
Identities = 27/81 (33%), Positives = 39/81 (48%), Gaps = 3/81 (3%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L++ HS VNC+ F P GN TAS+DG + I D G + L G H G ++ +
Sbjct: 220 LLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG---HTGPVFTV 276
Query: 101 SWSPDSTHLLSASGDKTSKIW 121
S+S S D +W
Sbjct: 277 SFSKGGELFASGGADTQVLLW 297
Score = 33.1 bits (74), Expect = 0.55
Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 6/118 (5%)
Query: 349 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFA 408
K +T + S +G LA + +++ ++ + GH + + +SP A
Sbjct: 18 KAAITSLDLSPNGKQLATASWDTFLMLWNFKP-HARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 409 SGGMDMMVYVWTLSDPETRVKIQD--AHRLHHVSSLAWLDEHTLVTTSHDASVKEWTI 464
S D V +W P+ R K + AH S D L T S D S+K W++
Sbjct: 77 SASRDRTVRLWI---PDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Score = 30.0 bits (66), Expect = 4.7
Identities = 20/75 (26%), Positives = 30/75 (40%), Gaps = 1/75 (1%)
Query: 388 FYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDE 447
F GH A I L SP+ + A+ D + +W P R H+ S
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK-PHARAYRYVGHKDVVTSVQFSPHG 72
Query: 448 HTLVTTSHDASVKEW 462
+ L + S D +V+ W
Sbjct: 73 NLLASASRDRTVRLW 87
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 62.4 bits (150), Expect = 8e-10
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 14/257 (5%)
Query: 169 PSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYW-DSETGENDSFAGKGHTNQ 227
P + GH ++ C+ +G + SGS D + W + GE+ F + HT
Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSPSG--HLLASGSRDKTVRIWVPNVKGESTVF--RAHTAT 67
Query: 228 VSRMTVDESGQ-LISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCI 286
V + GQ ++ S D TV+ + + + ++ +C P G +V
Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHIN-WVRCAKFSPDGRLIVSAS 126
Query: 287 GQIVLL---KDQRKCF-SIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDE 342
+ K R+C S G V HP G +A G+D V+++ + L
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 343 GKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP 402
+L A V +++ G +L + + + + +G + +GH +A+S
Sbjct: 187 YQLHSAA--VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTL-HGHQGPATTVAFSR 243
Query: 403 DNEHFASGGMDMMVYVW 419
E+FASGG D V VW
Sbjct: 244 TGEYFASGGSDEQVMVW 260
Score = 62.4 bits (150), Expect = 8e-10
Identities = 46/189 (24%), Positives = 81/189 (42%), Gaps = 11/189 (5%)
Query: 42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAIS 101
L ++ H +V C +FSPDG +AS D + ++D + E V + H G + +
Sbjct: 100 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY---CEHGGFVTYVD 156
Query: 102 WSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYI 161
+ P T + +A D T K+WDV + ++ + + S ++ L ++L++ S +
Sbjct: 157 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSFHPSGNYLITASSDSTL 215
Query: 162 NYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAG 221
LD + L+ + GH + + G Y SG D + W S N
Sbjct: 216 KILDLME-GRLLYTLHGHQGPATTVAFSRTG--EYFASGGSDEQVMVWKS----NFDIVD 268
Query: 222 KGHTNQVSR 230
G +V R
Sbjct: 269 HGEVTKVPR 277
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/211 (24%), Positives = 88/211 (41%), Gaps = 15/211 (7%)
Query: 48 HSRFVNCVRFSPDGNRFATASADGQIYIY-DGKTGEKVCALGGSKAHDGGIYAISWSPDS 106
H V CV FSP G+ A+ S D + I+ GE +AH + ++ + D
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV----FRAHTATVRSVHFCSDG 77
Query: 107 THLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSG--YINYL 164
++AS DKT K+W + + S ++ + D L VS S +
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSL---SQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 165 DRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGH 224
D+++ + +H H + + H +G + I + D + WD T + H
Sbjct: 135 DKSS-RECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWDVRTHRLLQHY-QLH 190
Query: 225 TNQVSRMTVDESGQ-LISCSMDDTVRYTSLM 254
+ V+ ++ SG LI+ S D T++ LM
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLM 221
Score = 43.9 bits (102), Expect = 3e-04
Identities = 31/114 (27%), Positives = 49/114 (42%), Gaps = 7/114 (6%)
Query: 41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI 100
+L++ HS VN + F P GN TAS+D + I D G + L G H G +
Sbjct: 183 LLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATTV 239
Query: 101 SWSPDSTHLLSASGDKTSKIW----DVSVNSVVSTFPMGSTVLDQQLGCLWQKD 150
++S + S D+ +W D+ + V+ P L +G L + D
Sbjct: 240 AFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVD 293
Score = 35.8 bits (81), Expect = 0.085
Identities = 60/296 (20%), Positives = 106/296 (35%), Gaps = 69/296 (23%)
Query: 93 HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHL 152
H + +++SP L S S DKT +IW +V + F
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF-------------------- 61
Query: 153 LSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVH-KNGGKSYIYSGSHDGHINYWDS 211
+ H+ +++ +VH + G+S++ + S D + W +
Sbjct: 62 ------------------------RAHTATVR--SVHFCSDGQSFV-TASDDKTVKVWAT 94
Query: 212 ETGENDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRYTSLMLRD----YSGQG--VV 264
+ F+ H N V G+LI S S D TV+ R+ Y G V
Sbjct: 95 HR-QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 153
Query: 265 KLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGG 324
+D P + G V + + + R ++ HP G+ +
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDV---RTHRLLQHYQLHSAAVNGLSFHPSGNYLITAS 210
Query: 325 VDGNVRLYSILGTTLKDEGKLLEA----KGPVTDVAYSHDGAFLAVCDASKVVTVF 376
D +++ ++ EG+LL +GP T VA+S G + A + + V V+
Sbjct: 211 SDSTLKILDLM------EGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 32.0 bits (71), Expect = 1.2
Identities = 40/170 (23%), Positives = 63/170 (37%), Gaps = 22/170 (12%)
Query: 305 GYEPEVVAVH--PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAK-GPVTDVAYSHDG 361
G++ V V+ P G +A G D VR++ +K E + A V V + DG
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWV---PNVKGESTVFRAHTATVRSVHFCSDG 77
Query: 362 AFLAVCDASKVVTVFSVADGYSENNVFY--GHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
K V V++ + + +F H + C +SPD S D V +W
Sbjct: 78 QSFVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 420 TLSDPETRVKIQDAHR-LHHVSSLAWLDEH----TLVTTSHDASVKEWTI 464
S E H H + ++D H + D +VK W +
Sbjct: 135 DKSSREC------VHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,478,275
Number of Sequences: 37866
Number of extensions: 915192
Number of successful extensions: 4154
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 180
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 1691
Number of HSP's gapped (non-prelim): 1744
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.