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Search of human proteins with 5174447
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
(317 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 662 0.0
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 131 7e-31
gi|16554629 WD repeat domain 5 [Homo sapiens] 123 2e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 123 2e-28
gi|23199987 WD repeat domain 5B [Homo sapiens] 122 4e-28
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 118 6e-27
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 117 2e-26
gi|26665869 WD repeat domain 51B [Homo sapiens] 112 4e-25
gi|32189425 WD repeat domain 69 [Homo sapiens] 106 3e-23
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 105 4e-23
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 104 1e-22
gi|21071067 TBP-associated factor 5 [Homo sapiens] 104 1e-22
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 103 2e-22
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 103 2e-22
gi|113865883 WD repeat domain 38 [Homo sapiens] 103 2e-22
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 102 4e-22
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 101 8e-22
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 101 8e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 100 2e-21
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 100 2e-21
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 96 4e-20
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 96 5e-20
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 96 5e-20
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 94 2e-19
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 93 3e-19
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 91 1e-18
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 90 2e-18
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 90 3e-18
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 90 3e-18
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 89 4e-18
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 662 bits (1707), Expect = 0.0
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60
MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR
Sbjct: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR 60
Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI
Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA
Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240
NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC 240
Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300
FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA
Sbjct: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300
Query: 301 GYTDNLVRVWQVTIGTR 317
GYTDNLVRVWQVTIGTR
Sbjct: 301 GYTDNLVRVWQVTIGTR 317
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 131 bits (330), Expect = 7e-31
Identities = 99/324 (30%), Positives = 141/324 (43%), Gaps = 42/324 (12%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
L GH VT++ P F M+ SAS D TI +W + G +R L+GH+ V D+
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMV-SASEDATIKVW-----DYETGDFERTLKGHTDSVQDIS 157
Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130
G+ S S D T++LWD R GH +V SVA + IVS SRDKTIK
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
Query: 131 LWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189
+W G C T H EWV VR PN +I SC D+ V+VW +A + K
Sbjct: 218 MWEVQTGYCVKTF--TGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVATKECKAELR 273
Query: 190 GHTGYLNTVTVSPD--------------------GSLCASGGKDGQAMLWDLNEGKHLYT 229
H + ++ +P+ G SG +D +WD++ G L T
Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
Query: 230 LDGGD--IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287
L G D + L S ++ L A ++++WD + K + L A T
Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL---------NAHEHFVT 384
Query: 288 SLAWSADGQTLFAGYTDNLVRVWQ 311
SL + + G D V+VW+
Sbjct: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 2e-28
Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 19/275 (6%)
Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103
K T + NY + + L GH+ VS V S +G++ S S D +++W G + G
Sbjct: 27 KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H + VA+SSD+ +VS S DKT+K+W+ + G C T++ HS +V C F+P S+
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 142
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
+IVS +D+ V++W++ K H+ ++ V + DGSL S DG +WD
Sbjct: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278
G+ L TL D ++ + FSPN +Y L A ++K+WD +GK + T
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-------TG 254
Query: 279 SKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312
K E C +S G + + +G DNLV +W +
Sbjct: 255 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 112 bits (281), Expect = 3e-25
Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%)
Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90
Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126
SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSGS D
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184
+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ + L
Sbjct: 151 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239
KT ++ V SP+G + D LWD ++GK L T G I
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK---QEVISTS 278
+ ++ + + + IW+L+ K IV +L+ VIST+
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Score = 87.4 bits (215), Expect = 1e-17
Identities = 59/215 (27%), Positives = 105/215 (48%), Gaps = 13/215 (6%)
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
GHTK V SV FS + + S S DK IK+W K+ H +S V +S +S+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGISDVAWSSDSN- 100
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
++VS DK +K+W++++ K GH+ Y+ +P +L SG D +WD+
Sbjct: 101 -LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 223 EGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSI-KIWDLEGKIIVDELKQEVISTSSK 280
GK L TL D ++A+ F+ + + +++ + +IWD + + T
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG--------QCLKTLID 211
Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
+ P + + +S +G+ + A DN +++W + G
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 11/214 (5%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V
Sbjct: 124 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128
+ DG +S S+DG R+WD +G + + +S V FS + + I++ + D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187
+KLW+ + G C T + ++ FS IVS D LV +WNL ++
Sbjct: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 296
Query: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219
GHT + + P ++ AS D LW
Sbjct: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87
IL+A+ D T+ +W ++ G + GH + + + + G++ +SGS D +
Sbjct: 229 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134
+W+L T ++ GHT V+S A I S + DKTIKLW +
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 11/137 (8%)
Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239
N LK GHT +++V SP+G AS D +W +GK T+ G + I+ +
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
+S + L +A+ ++KIWD+ + LK + C + ++ +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-------GHSNYVFCCN--FNPQSNLI 144
Query: 299 FAGYTDNLVRVWQVTIG 315
+G D VR+W V G
Sbjct: 145 VSGSFDESVRIWDVKTG 161
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (309), Expect = 2e-28
Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 19/275 (6%)
Query: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103
K T + NY + + L GH+ VS V S +G++ S S D +++W G + G
Sbjct: 27 KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
Query: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H + VA+SSD+ +VS S DKT+K+W+ + G C T++ HS +V C F+P S+
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 142
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
+IVS +D+ V++W++ K H+ ++ V + DGSL S DG +WD
Sbjct: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278
G+ L TL D ++ + FSPN +Y L A ++K+WD +GK + T
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-------TG 254
Query: 279 SKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312
K E C +S G + + +G DNLV +W +
Sbjct: 255 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 112 bits (281), Expect = 3e-25
Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%)
Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH +
Sbjct: 37 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90
Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126
SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSGS D
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
Query: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184
+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ + L
Sbjct: 151 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239
KT ++ V SP+G + D LWD ++GK L T G I
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK---QEVISTS 278
+ ++ + + + IW+L+ K IV +L+ VIST+
Sbjct: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
Score = 87.4 bits (215), Expect = 1e-17
Identities = 59/215 (27%), Positives = 105/215 (48%), Gaps = 13/215 (6%)
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
GHTK V SV FS + + S S DK IK+W K+ H +S V +S +S+
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDG-KFEKTISGHKLGISDVAWSSDSN- 100
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
++VS DK +K+W++++ K GH+ Y+ +P +L SG D +WD+
Sbjct: 101 -LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 223 EGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSI-KIWDLEGKIIVDELKQEVISTSSK 280
GK L TL D ++A+ F+ + + +++ + +IWD + + T
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG--------QCLKTLID 211
Query: 281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
+ P + + +S +G+ + A DN +++W + G
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKG 246
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 11/214 (5%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V
Sbjct: 124 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128
+ DG +S S+DG R+WD +G + + +S V FS + + I++ + D T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187
+KLW+ + G C T + ++ FS IVS D LV +WNL ++
Sbjct: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 296
Query: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219
GHT + + P ++ AS D LW
Sbjct: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87
IL+A+ D T+ +W ++ G + GH + + + + G++ +SGS D +
Sbjct: 229 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
Query: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134
+W+L T ++ GHT V+S A I S + DKTIKLW +
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 11/137 (8%)
Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239
N LK GHT +++V SP+G AS D +W +GK T+ G + I+ +
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
+S + L +A+ ++KIWD+ + LK + C + ++ +
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-------GHSNYVFCCN--FNPQSNLI 144
Query: 299 FAGYTDNLVRVWQVTIG 315
+G D VR+W V G
Sbjct: 145 VSGSFDESVRIWDVKTG 161
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 122 bits (306), Expect = 4e-28
Identities = 91/289 (31%), Positives = 146/289 (50%), Gaps = 23/289 (7%)
Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
+ LS+S +++ K + NY + + L GH+ VS V S +G++ S S D + +
Sbjct: 13 LALSSSANQS----KEVPENPNYAL-KCTLVGHTEAVSSVKFSPNGEWLASSSADRLIII 67
Query: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDESHS 148
W G + GH ++ VA+SSD+ ++VS S DKT+KLW+ G C T++ HS
Sbjct: 68 WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK--GHS 125
Query: 149 EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCA 208
+V C F+P S+ +I+S +D+ VK+W + K H+ ++ V + GSL
Sbjct: 126 NYVFCCNFNPPSN--LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIV 183
Query: 209 SGGKDGQAMLWDLNEGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDLE-GK 264
SG DG +WD G+ L TL D ++ + FSPN +Y L A ++K+WD G+
Sbjct: 184 SGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGR 243
Query: 265 IIVDELKQEVISTSSKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312
+ T K E C +S G + + +G DNLV +W +
Sbjct: 244 CLKTY-------TGHKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 284
Score = 114 bits (285), Expect = 1e-25
Identities = 85/272 (31%), Positives = 136/272 (50%), Gaps = 17/272 (6%)
Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
L+ TL GH V+ + +P + + S+S D+ II+W G ++ L GH+ +
Sbjct: 33 LKCTLVGHTEAVSSVKFSPN-GEWLASSSADRLIIIWGAYD-----GKYEKTLYGHNLEI 86
Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126
SDV SSD +S S D TL+LWD+ +G + GH+ V F+ + I+SGS D
Sbjct: 87 SDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFD 146
Query: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184
+T+K+W G C T+ +HS+ VS V F N S +IVS +D L ++W+ A+ + L
Sbjct: 147 ETVKIWEVKTGKCLKTL--SAHSDPVSAVHF--NCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239
KT ++ V SP+G + D LWD + G+ L T G I
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271
+ ++ + + + IW+L+ K IV +L+
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 294
Score = 89.0 bits (219), Expect = 5e-18
Identities = 67/217 (30%), Positives = 100/217 (46%), Gaps = 11/217 (5%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
TLKGH+ +V P ++I+S S D+T+ +W E G + L HS VS V
Sbjct: 120 TLKGHSNYVFCCNFNPP-SNLIISGSFDETVKIW-----EVKTGKCLKTLSAHSDPVSAV 173
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128
+ G +SGS+DG R+WD +G + V +S V FS + + I++ + D T
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNT 233
Query: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187
+KLW+ + G C T + ++ FS IVS D LV +WNL ++
Sbjct: 234 LKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 292
Query: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLWDLN 222
GHT + + P +L AS D LW N
Sbjct: 293 LQGHTDVVISAACHPTENLIASAALENDKTIKLWMSN 329
Score = 47.8 bits (112), Expect = 1e-05
Identities = 35/137 (25%), Positives = 66/137 (48%), Gaps = 11/137 (8%)
Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239
N LK +GHT +++V SP+G AS D ++W +GK+ TL G ++ I+ +
Sbjct: 30 NYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV 89
Query: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
+S + L +A+ ++K+WD+ + LK + C + ++ +
Sbjct: 90 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK-------GHSNYVFCCN--FNPPSNLI 140
Query: 299 FAGYTDNLVRVWQVTIG 315
+G D V++W+V G
Sbjct: 141 ISGSFDETVKIWEVKTG 157
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 118 bits (296), Expect = 6e-27
Identities = 83/279 (29%), Positives = 131/279 (46%), Gaps = 23/279 (8%)
Query: 37 DKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGT 96
D +++W + Y GH V+ V S G SGS D T+R+W
Sbjct: 2 DSCLMVWHMKPQSRAY-----RFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKG 56
Query: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF 156
+ F HT V SV F SD + V+ S DKT+K+W T K+ H WV C +F
Sbjct: 57 ESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ-KFLFSLSQHINWVRCAKF 115
Query: 157 SPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQA 216
SP+ +IVS DK VK+W+ ++ + ++ H G++ V P G+ A+ G D
Sbjct: 116 SPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
Query: 217 MLWDLNEGKHL--YTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQ 272
+WD+ + L Y L +N L F P+ Y + A++ ++KI DL EG+++
Sbjct: 174 KVWDVRTHRLLQHYQLHSA-AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY----- 227
Query: 273 EVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
+ T++A+S G+ +G +D V VW+
Sbjct: 228 -----TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
Score = 97.8 bits (242), Expect = 1e-20
Identities = 73/250 (29%), Positives = 111/250 (44%), Gaps = 13/250 (5%)
Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72
GH VT + +P ++ S SRDKT+ +W N R H+ V V
Sbjct: 21 GHKDAVTCVNFSPS-GHLLASGSRDKTVRIW-----VPNVKGESTVFRAHTATVRSVHFC 74
Query: 73 SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
SDGQ ++ S D T+++W H V FS D R IVS S DKT+KLW
Sbjct: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 134
Query: 133 N-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGH 191
+ + C ++ + H +V+ V F P S I + G D VKVW++ +L ++ H
Sbjct: 135 DKSSRECVHSYCE--HGGFVTYVDFHP--SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190
Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDIINALCFSPNRYWLC 249
+ +N ++ P G+ + D + DL EG+ LYTL G G Y+
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS 250
Query: 250 AATGPSIKIW 259
+ + +W
Sbjct: 251 GGSDEQVMVW 260
Score = 80.5 bits (197), Expect = 2e-15
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 32 LSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
++AS DKT+ +W R + + + Q H ++V S DG+ +S S D T++LWD
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQ-----HINWVRCAKFSPDGRLIVSASDDKTVKLWD 135
Query: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV 151
++ + H V V F I + D T+K+W+ + + + HS V
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAV 194
Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
+ + F P+ + +++ D +K+ +L +L GH G TV S G ASGG
Sbjct: 195 NGLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 252
Query: 212 KDGQAMLWDLN 222
D Q M+W N
Sbjct: 253 SDEQVMVWKSN 263
Score = 55.8 bits (133), Expect = 5e-08
Identities = 44/169 (26%), Positives = 75/169 (44%), Gaps = 11/169 (6%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
+L H WV +P +I+SAS DKT+ +W + E + + H FV+ V
Sbjct: 102 SLSQHINWVRCAKFSPD-GRLIVSASDDKTVKLWDKSSRECVHSYCE-----HGGFVTYV 155
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
G + D T+++WD+ T + + H+ V ++F +++ S D T+
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTL 215
Query: 130 KLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
K+ + + G YT+ H + V FS + S G D+ V VW
Sbjct: 216 KILDLMEGRLLYTL--HGHQGPATTVAFS--RTGEYFASGGSDEQVMVW 260
Score = 50.1 bits (118), Expect = 3e-06
Identities = 43/169 (25%), Positives = 73/169 (43%), Gaps = 15/169 (8%)
Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGS 205
H + V+CV FSP S ++ S DK V++W + N K ++ HT + +V DG
Sbjct: 22 HKDAVTCVNFSP--SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 206 LCASGGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWDLEG 263
+ D +W + K L++L + + FSP+ R + A+ ++K+WD
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138
Query: 264 KIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
+ V + T + + G + A DN V+VW V
Sbjct: 139 RECVHSYCEH---------GGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73
H G+VT + P I +A D T+ +W D + + Q + HS V+ +
Sbjct: 148 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVW----DVRTHRLLQH-YQLHSAAVNGLSFHP 201
Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
G + ++ S D TL++ DL G GH +VAFS SG D+ + +W
Sbjct: 202 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
Query: 134 T 134
+
Sbjct: 262 S 262
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 117 bits (292), Expect = 2e-26
Identities = 82/260 (31%), Positives = 127/260 (48%), Gaps = 15/260 (5%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R LRGH + + ++D + +S S DG L +WD T + V++ A++
Sbjct: 48 RRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
+ G D ++N G K + + +H+ ++SC RF N I+ S G D
Sbjct: 108 SGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL--DDNNIVTSSG-DT 164
Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
+W++ + KT +GHTG ++ VSPD +L SG D A LWD+ EG T G
Sbjct: 165 TCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTG 224
Query: 233 GDI-INALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
+ INA+CF PN +C + S +++DL QE+I S ++ TS+A
Sbjct: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRA-------DQELICFSHESIICGITSVA 277
Query: 291 WSADGQTLFAGYTDNLVRVW 310
+S G+ LFAGY D VW
Sbjct: 278 FSLSGRLLFAGYDDFNCNVW 297
Score = 72.0 bits (175), Expect = 6e-13
Identities = 67/252 (26%), Positives = 105/252 (41%), Gaps = 14/252 (5%)
Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
+ WV A P + + D ++ L E N + R L H+ ++S D
Sbjct: 97 SSWVMTCAYAPS-GNFVACGGLDNMCSIYNLKSREGNVKV-SRELSAHTGYLSCCRFLDD 154
Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
S S D T LWD+ TG FVGHT D +S+A S D +SG+ D + KLW+
Sbjct: 155 NNIVTS-SGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDV 213
Query: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGH 191
G C+ T H ++ + F PN I + D ++++L + + +H
Sbjct: 214 REGTCRQTF--TGHESDINAICFFPNGE--AICTGSDDASCRLFDLRADQELICFSHESI 269
Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
+ +V S G L +G D +WD + + + L G D C + A
Sbjct: 270 ICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHD-NRVSCLGVTADGMAVA 328
Query: 252 TG---PSIKIWD 260
TG +KIW+
Sbjct: 329 TGSWDSFLKIWN 340
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/225 (22%), Positives = 82/225 (36%), Gaps = 59/225 (26%)
Query: 97 TTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRF 156
T R GH + ++ +++D++ +VS S+D + +W++ K S WV +
Sbjct: 47 TRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIP-LRSSWVMTCAY 105
Query: 157 SPNSSNPIIVSCGW-DKLVKVWNL----ANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
+P+ + V+CG D + ++NL N K+ HTGYL+ D ++ S G
Sbjct: 106 APSGN---FVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG 162
Query: 212 KDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELK 271
D LWD+ G+ G TG
Sbjct: 163 -DTTCALWDIETGQQKTVFVGH------------------TG------------------ 185
Query: 272 QEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGT 316
C SLA S D +G D ++W V GT
Sbjct: 186 -------------DCMSLAVSPDFNLFISGACDASAKLWDVREGT 217
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 112 bits (280), Expect = 4e-25
Identities = 79/302 (26%), Positives = 130/302 (43%), Gaps = 60/302 (19%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R +GH ++ + +S +G+ + SWD L LW+ R+VGH V SV FS
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 116 DNRQIVSGSRDKTIKLW-----------------------NTLGVCKYTVQDES------ 146
+ S SRD+T++LW + G T ++
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 147 ------------HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194
H+ WV C +FSP+ +IVSC DK +K+W+ N + N G+
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGR--LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGK---HLYTLDGGDIINALCFSPN-RYWLCA 250
N V +P G+ AS G D +WD+ K H GG +N + F P+ Y + A
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGG--VNCISFHPSGNYLITA 246
Query: 251 ATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309
++ ++KI D LEG++I + + ++++S G+ +G D V +
Sbjct: 247 SSDGTLKILDLLEGRLIY----------TLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296
Query: 310 WQ 311
W+
Sbjct: 297 WR 298
Score = 109 bits (273), Expect = 3e-24
Identities = 76/226 (33%), Positives = 114/226 (50%), Gaps = 21/226 (9%)
Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRA-----LRGHSHFVS 67
GH VT + +P +++ SASRD+T+ +W IP + + H+ V
Sbjct: 58 GHKDVVTSVQFSPH-GNLLASASRDRTVRLW----------IPDKRGKFSEFKAHTAPVR 106
Query: 68 DVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDK 127
V S+DGQF + S D ++++W + HT V FS D R IVS S DK
Sbjct: 107 SVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDK 166
Query: 128 TIKLWNTLGVCKYTVQDESHSE-WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT 186
TIK+W+T K V + S S + + V F+P S I S G D+ VKVW++ KL
Sbjct: 167 TIKIWDTTN--KQCVNNFSDSVGFANFVDFNP--SGTCIASAGSDQTVKVWDVRVNKLLQ 222
Query: 187 NHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
++ H+G +N ++ P G+ + DG + DL EG+ +YTL G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQG 268
Score = 95.1 bits (235), Expect = 7e-20
Identities = 61/192 (31%), Positives = 95/192 (49%), Gaps = 8/192 (4%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
+ +AS DK+I +W + R Y +L H+H+V S DG+ +S S D T+++W
Sbjct: 117 LATASEDKSIKVWSMYRQRFLY-----SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
D T F V F+ I S D+T+K+W+ + V K + HS
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD-VRVNKLLQHYQVHSGG 230
Query: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASG 210
V+C+ F P+ + +++ D +K+ +L +L GHTG + TV+ S G L ASG
Sbjct: 231 VNCISFHPSGN--YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASG 288
Query: 211 GKDGQAMLWDLN 222
G D Q +LW N
Sbjct: 289 GADTQVLLWRTN 300
Score = 51.2 bits (121), Expect = 1e-06
Identities = 38/171 (22%), Positives = 73/171 (42%), Gaps = 13/171 (7%)
Query: 145 ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204
+ H ++ + SPN + + WD + +WN ++GH + +V SP G
Sbjct: 15 KGHKAAITSLDLSPNGKQ--LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHG 72
Query: 205 SLCASGGKDGQAMLWDLNE-GKHLYTLDGGDIINALCFSPNRYWLCAAT-GPSIKIWDLE 262
+L AS +D LW ++ GK + ++ FS + +L A+ SIK+W +
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 263 GKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313
+ + L + +C +S DG+ + + D +++W T
Sbjct: 133 RQRFLYSLYRHTHWV-------RCAK--FSPDGRLIVSCSEDKTIKIWDTT 174
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 106 bits (264), Expect = 3e-23
Identities = 63/224 (28%), Positives = 108/224 (48%), Gaps = 11/224 (4%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
T +GH + ++ PQ ++ + S D T +W + E Y LRGHS + +
Sbjct: 172 TFRGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQNGEEVY-----TLRGHSAEIISL 225
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
++ G ++GS+D T+ +WD TG +GH ++ S +F+ D I++GS DKT
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Query: 130 KLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
KLW+ T G C T+ SC + + +I + D ++++ A K
Sbjct: 286 KLWDATNGKCVATLTGHDDEILDSCFDY----TGKLIATASADGTARIFSAATRKCIAKL 341
Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
GH G ++ ++ +P G+ +G D A +WD G+ L L+G
Sbjct: 342 EGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385
Score = 101 bits (252), Expect = 8e-22
Identities = 77/304 (25%), Positives = 136/304 (44%), Gaps = 19/304 (6%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
TL+GH V IA + D I + S DKT +W + ET G RGH+ + +
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV---ET--GKCYHTFRGHTAEIVCL 183
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
+ +GS D T +LWD+ G GH+ +++S++F++ +I++GS D T+
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243
Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189
+W+ K + H +S F+ + S +I++ DK K+W+ N K
Sbjct: 244 VVWDADTGRKVNIL-IGHCAEISSASFNWDCS--LILTGSMDKTCKLWDATNGKCVATLT 300
Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-IINALCFSP-NRYW 247
GH + G L A+ DG A ++ K + L+G + I+ + F+P +
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307
L ++ + +IWD + + L + + S A++ G + G DN
Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVL---------EGHTDEIFSCAFNYKGNIVITGSKDNTC 411
Query: 308 RVWQ 311
R+W+
Sbjct: 412 RIWR 415
Score = 100 bits (250), Expect = 1e-21
Identities = 79/308 (25%), Positives = 131/308 (42%), Gaps = 21/308 (6%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
LK H +T +A ++ S D+T +W +T G L GH + V +
Sbjct: 88 LKAHILPLTNVALNKS-GSCFITGSYDRTCKLW-----DTASGEELNTLEGHRNVVYAIA 141
Query: 71 ISSD-GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
++ G +GS+D T +LW + TG F GHT +++ ++F+ + + +GS D T
Sbjct: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 130 KLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
KLW+ G YT++ S + S N+S I++ +D V VW+ +
Sbjct: 202 KLWDIQNGEEVYTLRGHS----AEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL 257
Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYW 247
IGH +++ + + D SL +G D LWD GK + TL G D I CF
Sbjct: 258 IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFD----- 312
Query: 248 LCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307
TG I +G + + + + ++++ G L G +D
Sbjct: 313 ---YTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA 369
Query: 308 RVWQVTIG 315
R+W G
Sbjct: 370 RIWDAQTG 377
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 105 bits (263), Expect = 4e-23
Identities = 89/351 (25%), Positives = 151/351 (43%), Gaps = 66/351 (18%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
T KGH WV I+ +P + S ++ I++W D + R L GHS +++ +
Sbjct: 151 TCKGHRHWVLSISWSPD-GRKLASGCKNGQILLW----DPSTGKQVGRTLAGHSKWITGL 205
Query: 70 V-----ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124
+ + ++ S S DG++R+WD T G R GHT+ V + + D + S S
Sbjct: 206 SWEPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSAS 264
Query: 125 RDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPN-------------SSNP------- 163
+D+TIK+W GV T+Q H WV+ + S + S NP
Sbjct: 265 QDRTIKVWRAHDGVLCRTLQ--GHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSL 322
Query: 164 ------------IIVSCGWDKLVK--------VWNLANCKLK-TNHIGHTGYLNTVTVSP 202
++ G ++LV +W+ A K T GH +N V SP
Sbjct: 323 QELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP 382
Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG--GDIINALCFSPNRYWLCAATGPSIKIWD 260
D + AS D LWD GK+L +L G + + +R + ++ ++K+WD
Sbjct: 383 DSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWD 442
Query: 261 LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
++ + + +L + ++ WS DGQ + +G D +R+W+
Sbjct: 443 VKAQKLAMDLP---------GHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 104 bits (259), Expect = 1e-22
Identities = 94/356 (26%), Positives = 155/356 (43%), Gaps = 74/356 (20%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
+L+GH+ V +A +P + S S D T+ W L+ + P +GH H+V +
Sbjct: 109 SLEGHSEAVISVAFSPT-GKYLASGSGDTTVRFWDLSTET-----PHFTCKGHRHWVLSI 162
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTT-RRFVGHTKDVLSVAF-----SSDNRQIVSG 123
S DG+ SG +G + LWD +TG R GH+K + +++ + + R + S
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASS 222
Query: 124 SRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
S+D ++++W+ T G C+ + H++ V+C+R+ + ++ S D+ +KVW +
Sbjct: 223 SKDGSVRIWDTTAGRCERIL--TGHTQSVTCLRW---GGDGLLYSASQDRTIKVWRAHDG 277
Query: 183 KLKTNHIGHTGYLNTVTVSPD---------------------GSL--------------- 206
L GH ++NT+ +S D GSL
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
Query: 207 ------CASGGKDGQAMLWDLNEGKHLYTLDGGD--IINALCFSP-NRYWLCAATGPSIK 257
SG D LW E K T G +IN + FSP +R A+ SIK
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397
Query: 258 IWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
+WD GK + S + +AWSAD + L +G +D+ ++VW V
Sbjct: 398 LWDGRTGKYL----------ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Score = 67.8 bits (164), Expect = 1e-11
Identities = 70/239 (29%), Positives = 105/239 (43%), Gaps = 45/239 (18%)
Query: 106 KDVLSVAFSSDNRQIVSGSRDKTIK------------------LWNTLGVCKYTVQDESH 147
+D L +AF + +IVS S KT++ ++ V + T E H
Sbjct: 55 EDPLPLAFFVHDAEIVS-SLGKTLESQAVETEKVLDIIYQPQAIFRVRAVTRCTSSLEGH 113
Query: 148 SEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI---GHTGYLNTVTVSPDG 204
SE V V FSP + + S D V+ W+L+ +T H GH ++ +++ SPDG
Sbjct: 114 SEAVISVAFSP--TGKYLASGSGDTTVRFWDLST---ETPHFTCKGHRHWVLSISWSPDG 168
Query: 205 SLCASGGKDGQAMLWDLNEGKHL-YTLDG-GDIINALCFSP------NRYWLCAATGPSI 256
ASG K+GQ +LWD + GK + TL G I L + P RY ++ S+
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 257 KIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
+IWD + E I T T L W DG L++ D ++VW+ G
Sbjct: 229 RIWDTTAG------RCERILT---GHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 104 bits (259), Expect = 1e-22
Identities = 73/257 (28%), Positives = 126/257 (49%), Gaps = 14/257 (5%)
Query: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117
+L GH+ V V +++ + ++GS G++R+WDL R +GH ++ S+ F
Sbjct: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
Query: 118 RQIVSGSRDKTIKLWNTLG---VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
+ SGS+D IKLW+ V +Y HS+ V C+RFSP+ + S D V
Sbjct: 118 EFVASGSQDTNIKLWDIRRKGCVFRY----RGHSQAVRCLRFSPDGK--WLASAADDHTV 171
Query: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-G 233
K+W+L K+ + GHTG +N V P+ L ASG D WDL + + + ++G
Sbjct: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEP 231
Query: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT-SLAWS 292
+ ++ F+P+ L + S++++ E + D + +++ A+ C L
Sbjct: 232 GPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV---LVNWGKVADLAICNDQLIGV 288
Query: 293 ADGQTLFAGYTDNLVRV 309
A Q+ + Y +L RV
Sbjct: 289 AFSQSNVSSYVVDLTRV 305
Score = 92.4 bits (228), Expect = 5e-19
Identities = 69/248 (27%), Positives = 112/248 (45%), Gaps = 15/248 (6%)
Query: 62 HSHFVSDVVIS-SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
H+ VS +V+ + G+ +G D + LW + GHT V SV ++ I
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
Query: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
V+GS+ +I++W+ L K H + + F P + S D +K+W++
Sbjct: 79 VAGSQSGSIRVWD-LEAAKILRTLMGHKANICSLDFHPYGE--FVASGSQDTNIKLWDIR 135
Query: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINAL 239
+ GH+ + + SPDG AS D LWDL GK + G +N +
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
Query: 240 CFSPNRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
F PN Y L + + +I+ WDLE K +V+S + EP S+ ++ DG L
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLE--------KFQVVS-CIEGEPGPVRSVLFNPDGCCL 246
Query: 299 FAGYTDNL 306
++G D+L
Sbjct: 247 YSGCQDSL 254
Score = 84.3 bits (207), Expect = 1e-16
Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 11/205 (5%)
Query: 10 TLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
+L GH V + TP+ ++I++ S+ +I +W L + R L GH +
Sbjct: 58 SLTGHTSPVESVRLNTPE--ELIVAGSQSGSIRVWDLEAAKI-----LRTLMGHKANICS 110
Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
+ G+F SGS D ++LWD+ R+ GH++ V + FS D + + S + D T
Sbjct: 111 LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHT 170
Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
+KLW+ L K + H+ V+ V F PN ++ S D+ ++ W+L ++ +
Sbjct: 171 VKLWD-LTAGKMMSEFPGHTGPVNVVEFHPNEY--LLASGSSDRTIRFWDLEKFQVVSCI 227
Query: 189 IGHTGYLNTVTVSPDGSLCASGGKD 213
G G + +V +PDG SG +D
Sbjct: 228 EGEPGPVRSVLFNPDGCCLYSGCQD 252
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 11/158 (6%)
Query: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
+S ++ + G D V +W++ + GHT + +V ++ L +G + G +W
Sbjct: 31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 220 DLNEGKHLYTLDGGDI-INALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277
DL K L TL G I +L F P ++ + + +IK+WD+ K V +
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYR------ 144
Query: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
++ +C L +S DG+ L + D+ V++W +T G
Sbjct: 145 -GHSQAVRC--LRFSPDGKWLASAADDHTVKLWDLTAG 179
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 104 bits (259), Expect = 1e-22
Identities = 67/206 (32%), Positives = 102/206 (49%), Gaps = 5/206 (2%)
Query: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116
+ L GHS V S D + LS S DGT+RLW L T T + GH V FS
Sbjct: 537 KILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPY 596
Query: 117 NRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176
VSG D+ +LW T + H V+C RF PNS+ + + D+ V++
Sbjct: 597 GYYFVSGGHDRVARLWATDHYQPLRI-FAGHLADVNCTRFHPNSN--YVATGSADRTVRL 653
Query: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDI 235
W++ N GH G ++++T SP+G A+G DG+ +LWD+ G + L G D
Sbjct: 654 WDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT 713
Query: 236 INALCFSPNRYWLCAAT-GPSIKIWD 260
+ +L FS + L + + ++++WD
Sbjct: 714 VCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 91.3 bits (225), Expect = 1e-18
Identities = 78/284 (27%), Positives = 124/284 (43%), Gaps = 32/284 (11%)
Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
+I D T+ +W +T P++ + V +SD S D R+
Sbjct: 484 LIAGGFADSTVRVWSVT--------PKK--------LRSVKQASDLSLIDKESDDVLERI 527
Query: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSE 149
D T + + GH+ V +FS D ++S S D T++LW +L V + H+
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW-SLQTFTCLVGYKGHNY 586
Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAS 209
V +FSP VS G D++ ++W + + GH +N P+ + A+
Sbjct: 587 PVWDTQFSPYGY--YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVAT 644
Query: 210 GGKDGQAMLWDLNEGK--HLYTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKII 266
G D LWD+ G ++T G I++L FSPN R+ AT + +WD+ ++
Sbjct: 645 GSADRTVRLWDVLNGNCVRIFTGHKGP-IHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310
V EL K SL +S DG+ L +G DN VR+W
Sbjct: 704 VGEL---------KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 70.9 bits (172), Expect = 1e-12
Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 13/169 (7%)
Query: 12 KGHNG--WVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
KGHN W TQ + + +S D+ +W T++ P R GH V+
Sbjct: 582 KGHNYPVWDTQFSPYGYY---FVSGGHDRVARLWA-----TDHYQPLRIFAGHLADVNCT 633
Query: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTI 129
+ + +GS D T+RLWD+ G R F GH + S+ FS + R + +G+ D +
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
LW+ +G + + H++ V +RFS + I+ S D V++W+
Sbjct: 694 LLWD-IGHGLMVGELKGHTDTVCSLRFSRDGE--ILASGSMDNTVRLWD 739
Score = 67.0 bits (162), Expect = 2e-11
Identities = 33/105 (31%), Positives = 53/105 (50%), Gaps = 5/105 (4%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
+ + S D+T+ +W + G R GH + + S +G+F +G+ DG + LW
Sbjct: 642 VATGSADRTVRLWDVLN-----GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL 135
D+ G GHT V S+ FS D + SGS D T++LW+ +
Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 55.8 bits (133), Expect = 5e-08
Identities = 63/250 (25%), Positives = 100/250 (40%), Gaps = 27/250 (10%)
Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
V ++ D G D T+R+W +T K + SV +SD I S D
Sbjct: 476 VDVTDDSSLIAGGFADSTVRVWSVTP-----------KKLRSVKQASDLSLIDKESDDVL 524
Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
++ + + + HS V FSP+ + ++S D V++W+L +
Sbjct: 525 ERIMDEKTASELKIL-YGHSGPVYGASFSPDRN--YLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INALCFSPNRYW 247
GH + SP G SGG D A LW + + L G +N F PN +
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY 641
Query: 248 LCAATGP-SIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDN 305
+ + ++++WD L G + I T K SL +S +G+ L G TD
Sbjct: 642 VATGSADRTVRLWDVLNGNCVR-------IFTGHKGP---IHSLTFSPNGRFLATGATDG 691
Query: 306 LVRVWQVTIG 315
V +W + G
Sbjct: 692 RVLLWDIGHG 701
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 103 bits (258), Expect = 2e-22
Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 58/301 (19%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R +GH V+ V S + + SGS D L +W + + RF GH V V FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 116 DNRQIVSGSRDKTIKLW------------------NTLGVC------------------- 138
+ SGSRDKT+++W ++ C
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 139 ----KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194
K+ H WV C +FSP+ +IVS DK VK+W+ ++ + ++ H G+
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL--YTLDGGDIINALCFSPN-RYWLCAA 251
+ V P G+ A+ G D +WD+ + L Y L +N L F P+ Y + A+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA-AVNGLSFHPSGNYLITAS 248
Query: 252 TGPSIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310
+ ++KI DL EG+++ + T++A+S G+ +G +D V VW
Sbjct: 249 SDSTLKILDLMEGRLLY----------TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Query: 311 Q 311
+
Sbjct: 299 K 299
Score = 100 bits (250), Expect = 1e-21
Identities = 79/301 (26%), Positives = 116/301 (38%), Gaps = 53/301 (17%)
Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62
E +L KGH VT + + + S S D +++W + Y GH
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSIN-TKQLASGSMDSCLMVWHMKPQSRAY-----RFTGH 60
Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+ V S G SGS D T+R+W + F HT V SV F SD + V+
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
S DKT+K+W T K+ H WV C +FSP+ +IVS DK VK+W+ ++
Sbjct: 121 ASDDKTVKVWATHRQ-KFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177
Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD---------------------- 220
+ ++ H G++ V P G+ A+ G D +WD
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 221 --------------------LNEGKHLYTLDG--GDIINALCFSPNRYWLCAATGPSIKI 258
L EG+ LYTL G G Y+ + + +
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 259 W 259
W
Sbjct: 298 W 298
Score = 80.5 bits (197), Expect = 2e-15
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 32 LSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
++AS DKT+ +W R + + + Q H ++V S DG+ +S S D T++LWD
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQ-----HINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV 151
++ + H V V F I + D T+K+W+ + + + HS V
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAV 232
Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
+ + F P+ + +++ D +K+ +L +L GH G TV S G ASGG
Sbjct: 233 NGLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 212 KDGQAMLWDLN 222
D Q M+W N
Sbjct: 291 SDEQVMVWKSN 301
Score = 69.7 bits (169), Expect = 3e-12
Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 16/217 (7%)
Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158
R F GH V V FS + +Q+ SGS D + +W+ + + H + V+CV FSP
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSR-AYRFTGHKDAVTCVNFSP 71
Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGSLCASGGKDGQAM 217
S ++ S DK V++W + N K ++ HT + +V DG + D
Sbjct: 72 --SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 218 LWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVI 275
+W + K L++L + + FSP+ R + A+ ++K+WD + V +
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH-- 186
Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
T + + G + A DN V+VW V
Sbjct: 187 -------GGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73
H G+VT + P I +A D T+ +W D + + Q + HS V+ +
Sbjct: 186 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVW----DVRTHRLLQH-YQLHSAAVNGLSFHP 239
Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
G + ++ S D TL++ DL G GH +VAFS SG D+ + +W
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Query: 134 T 134
+
Sbjct: 300 S 300
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 11/129 (8%)
Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFS 242
L+ + GH + V S + ASG D M+W + Y G D + + FS
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 243 PNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301
P+ + L + + +++IW V +K E ST +A S+ + +DGQ+
Sbjct: 71 PSGHLLASGSRDKTVRIW-------VPNVKGE--STVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 302 YTDNLVRVW 310
D V+VW
Sbjct: 122 SDDKTVKVW 130
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 103 bits (258), Expect = 2e-22
Identities = 79/301 (26%), Positives = 129/301 (42%), Gaps = 58/301 (19%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R +GH V+ V S + + SGS D L +W + + RF GH V V FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 116 DNRQIVSGSRDKTIKLW------------------NTLGVC------------------- 138
+ SGSRDKT+++W ++ C
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 139 ----KYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGY 194
K+ H WV C +FSP+ +IVS DK VK+W+ ++ + ++ H G+
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSRECVHSYCEHGGF 189
Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL--YTLDGGDIINALCFSPN-RYWLCAA 251
+ V P G+ A+ G D +WD+ + L Y L +N L F P+ Y + A+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSA-AVNGLSFHPSGNYLITAS 248
Query: 252 TGPSIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVW 310
+ ++KI DL EG+++ + T++A+S G+ +G +D V VW
Sbjct: 249 SDSTLKILDLMEGRLLY----------TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Query: 311 Q 311
+
Sbjct: 299 K 299
Score = 100 bits (250), Expect = 1e-21
Identities = 79/301 (26%), Positives = 116/301 (38%), Gaps = 53/301 (17%)
Query: 3 EQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGH 62
E +L KGH VT + + + S S D +++W + Y GH
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSIN-TKQLASGSMDSCLMVWHMKPQSRAY-----RFTGH 60
Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+ V S G SGS D T+R+W + F HT V SV F SD + V+
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 123 GSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC 182
S DKT+K+W T K+ H WV C +FSP+ +IVS DK VK+W+ ++
Sbjct: 121 ASDDKTVKVWATHRQ-KFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177
Query: 183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD---------------------- 220
+ ++ H G++ V P G+ A+ G D +WD
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 221 --------------------LNEGKHLYTLDG--GDIINALCFSPNRYWLCAATGPSIKI 258
L EG+ LYTL G G Y+ + + +
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 259 W 259
W
Sbjct: 298 W 298
Score = 80.5 bits (197), Expect = 2e-15
Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 8/191 (4%)
Query: 32 LSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
++AS DKT+ +W R + + + Q H ++V S DG+ +S S D T++LWD
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQ-----HINWVRCAKFSPDGRLIVSASDDKTVKLWD 173
Query: 92 LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV 151
++ + H V V F I + D T+K+W+ + + + HS V
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAV 232
Query: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGG 211
+ + F P+ + +++ D +K+ +L +L GH G TV S G ASGG
Sbjct: 233 NGLSFHPSGN--YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 212 KDGQAMLWDLN 222
D Q M+W N
Sbjct: 291 SDEQVMVWKSN 301
Score = 69.7 bits (169), Expect = 3e-12
Identities = 57/217 (26%), Positives = 95/217 (43%), Gaps = 16/217 (7%)
Query: 99 RRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSP 158
R F GH V V FS + +Q+ SGS D + +W+ + + H + V+CV FSP
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSR-AYRFTGHKDAVTCVNFSP 71
Query: 159 NSSNPIIVSCGWDKLVKVWNLANCKLKTNHI-GHTGYLNTVTVSPDGSLCASGGKDGQAM 217
S ++ S DK V++W + N K ++ HT + +V DG + D
Sbjct: 72 --SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 218 LWDLNEGKHLYTLDGG-DIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVI 275
+W + K L++L + + FSP+ R + A+ ++K+WD + V +
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH-- 186
Query: 276 STSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
T + + G + A DN V+VW V
Sbjct: 187 -------GGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/121 (27%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73
H G+VT + P I +A D T+ +W D + + Q + HS V+ +
Sbjct: 186 HGGFVTYVDFHPS-GTCIAAAGMDNTVKVW----DVRTHRLLQH-YQLHSAAVNGLSFHP 239
Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
G + ++ S D TL++ DL G GH +VAFS SG D+ + +W
Sbjct: 240 SGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Query: 134 T 134
+
Sbjct: 300 S 300
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/129 (26%), Positives = 56/129 (43%), Gaps = 11/129 (8%)
Query: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFS 242
L+ + GH + V S + ASG D M+W + Y G D + + FS
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFS 70
Query: 243 PNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAG 301
P+ + L + + +++IW V +K E ST +A S+ + +DGQ+
Sbjct: 71 PSGHLLASGSRDKTVRIW-------VPNVKGE--STVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 302 YTDNLVRVW 310
D V+VW
Sbjct: 122 SDDKTVKVW 130
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 103 bits (257), Expect = 2e-22
Identities = 88/321 (27%), Positives = 126/321 (39%), Gaps = 76/321 (23%)
Query: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISS 73
H G V A +P M+L+ S D + W ET G L GH+ V S
Sbjct: 20 HGGEVNSSAFSPD-GQMLLTGSEDGCVYGW-----ETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
DG S S D T+RLWD+ R GH + V +V+FS D+RQ+ SG DK + LW+
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 134 -----------------------------TLGVCKYTVQD---------------ESHSE 149
G TV E HS
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAS 209
+SC+ + S++ ++ S WDK + +W L GH ++ ++ SPD AS
Sbjct: 194 NISCLCY---SASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250
Query: 210 GGKDGQAMLWDLNEGKHLYTLDGG-DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIV- 267
G +WD N GK L TL G D+ + F+P +GKI+V
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP------------------DGKILVS 292
Query: 268 ---DELKQEVISTSSKAEPPQ 285
D+ ++++ TS PQ
Sbjct: 293 GAADQTRRQISRTSKSPRDPQ 313
Score = 84.0 bits (206), Expect = 2e-16
Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 16/217 (7%)
Query: 101 FVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNS 160
F H +V S AFS D + +++GS D + W T + + H+ V RFSP+
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRS-GQLLWRLGGHTGPVKFCRFSPDG 75
Query: 161 SNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
+ S D V++W++A K GH + TV+ SPD ASGG D + MLWD
Sbjct: 76 H--LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133
Query: 221 LNEGKHLYTLDG-GDIINALCFSPNRYWLCAATG---PSIKIWDLEGKIIVDELKQEVIS 276
+ G+ L L G D I + FSP C ATG ++ IWDL +++ + + +
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVN--CLATGSWDSTVHIWDL--RMVTPAVSHQALE 189
Query: 277 TSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313
S + L +SA G L +G D + +W+ T
Sbjct: 190 GHS----ANISCLCYSASG-LLASGSWDKTIHIWKPT 221
Score = 31.6 bits (70), Expect = 0.97
Identities = 23/78 (29%), Positives = 34/78 (43%), Gaps = 6/78 (7%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
LKGH WV IA +P + SA + + +W + N G L+G
Sbjct: 229 LKGHVTWVKSIAFSPD-ELWLASAGYSRMVKVW-----DCNTGKCLETLKGVLDVAHTCA 282
Query: 71 ISSDGQFALSGSWDGTLR 88
+ DG+ +SG+ D T R
Sbjct: 283 FTPDGKILVSGAADQTRR 300
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 102 bits (254), Expect = 4e-22
Identities = 73/260 (28%), Positives = 121/260 (46%), Gaps = 15/260 (5%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R LRGH + + +D + +S S DG L +WD T + V++ A++
Sbjct: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
+ G D ++N G + + + H+ ++SC RF N I+ S G D
Sbjct: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL--DDNQIVTSSG-DT 164
Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
+W++ + T GHTG + +++++PD L SG D A LWD+ EG T G
Sbjct: 165 TCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTG 224
Query: 233 GDI-INALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
+ INA+CF PN + + + +++DL QE+++ S TS++
Sbjct: 225 HESDINAICFFPNGNAFATGSDDATCRLFDLRA-------DQELMTYSHDNIICGITSVS 277
Query: 291 WSADGQTLFAGYTDNLVRVW 310
+S G+ L AGY D VW
Sbjct: 278 FSKSGRLLLAGYDDFNCNVW 297
Score = 83.2 bits (204), Expect = 3e-16
Identities = 72/252 (28%), Positives = 112/252 (44%), Gaps = 14/252 (5%)
Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
+ WV A P + + D ++ L E N + R L GH+ ++S D
Sbjct: 97 SSWVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRV-SRELAGHTGYLSCCRFLDD 154
Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
Q S S D T LWD+ TG T F GHT DV+S++ + D R VSG+ D + KLW+
Sbjct: 155 NQIVTS-SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDV 213
Query: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL-ANCKLKT-NHIGH 191
G+C+ T H ++ + F PN + + D ++++L A+ +L T +H
Sbjct: 214 REGMCRQTF--TGHESDINAICFFPNGN--AFATGSDDATCRLFDLRADQELMTYSHDNI 269
Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
+ +V+ S G L +G D +WD + L G D C + A
Sbjct: 270 ICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHD-NRVSCLGVTDDGMAVA 328
Query: 252 TG---PSIKIWD 260
TG +KIW+
Sbjct: 329 TGSWDSFLKIWN 340
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 101 bits (252), Expect = 8e-22
Identities = 79/280 (28%), Positives = 124/280 (44%), Gaps = 20/280 (7%)
Query: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 597 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 713
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 223 EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKI--WDLEGKIIVDELKQEVI--STS 278
+ IN F N +K W +G I+ K ++ +T
Sbjct: 774 SANERKS------INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 827
Query: 279 SKAEPPQCTS-LAW------SADGQTLFAGYTDNLVRVWQ 311
S+++ C L+W S DG + D +R+W+
Sbjct: 828 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 867
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 975 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1027
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 1028 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1086
Query: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 1087 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1143
Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
PDG + S G G W++ G+ T
Sbjct: 1144 PDGKMLISAG--GYIKWWNVVTGESSQT 1169
Score = 68.2 bits (165), Expect = 9e-12
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 921 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 980
Query: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 981 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1034
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 1035 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1094
Query: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 1095 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1150
Query: 300 AGYTDNLVRVWQVTIG 315
+ ++ W V G
Sbjct: 1151 S--AGGYIKWWNVVTG 1164
Score = 45.1 bits (105), Expect = 8e-05
Identities = 39/144 (27%), Positives = 59/144 (40%), Gaps = 10/144 (6%)
Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRG 61
Q R T+ GH V +P ++ S S D T+ +W T + + + Q L
Sbjct: 732 QKECRNTMFGHTNSVNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 790
Query: 62 HSHFVSDVVI------SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
VI S+DG + + + LW+ + + GH V V FS
Sbjct: 791 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP 849
Query: 116 DNRQIVSGSRDKTIKLWNTLGVCK 139
D ++ S D+TI+LW T VCK
Sbjct: 850 DGSSFLTSSDDQTIRLWETKKVCK 873
Score = 37.4 bits (85), Expect = 0.018
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 1080 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 1137 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1191
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 101 bits (252), Expect = 8e-22
Identities = 79/280 (28%), Positives = 124/280 (44%), Gaps = 20/280 (7%)
Query: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 586 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 702
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 223 EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKI--WDLEGKIIVDELKQEVI--STS 278
+ IN F N +K W +G I+ K ++ +T
Sbjct: 763 SANERKS------INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 816
Query: 279 SKAEPPQCTS-LAW------SADGQTLFAGYTDNLVRVWQ 311
S+++ C L+W S DG + D +R+W+
Sbjct: 817 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 964 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1016
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 1017 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1075
Query: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 1076 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1132
Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
PDG + S G G W++ G+ T
Sbjct: 1133 PDGKMLISAG--GYIKWWNVVTGESSQT 1158
Score = 68.2 bits (165), Expect = 9e-12
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 969
Query: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 970 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1023
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 1024 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1083
Query: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 1084 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1139
Query: 300 AGYTDNLVRVWQVTIG 315
+ ++ W V G
Sbjct: 1140 S--AGGYIKWWNVVTG 1153
Score = 45.1 bits (105), Expect = 8e-05
Identities = 39/144 (27%), Positives = 59/144 (40%), Gaps = 10/144 (6%)
Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRG 61
Q R T+ GH V +P ++ S S D T+ +W T + + + Q L
Sbjct: 721 QKECRNTMFGHTNSVNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Query: 62 HSHFVSDVVI------SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
VI S+DG + + + LW+ + + GH V V FS
Sbjct: 780 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP 838
Query: 116 DNRQIVSGSRDKTIKLWNTLGVCK 139
D ++ S D+TI+LW T VCK
Sbjct: 839 DGSSFLTSSDDQTIRLWETKKVCK 862
Score = 37.4 bits (85), Expect = 0.018
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 1069 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 1126 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1180
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 100 bits (249), Expect = 2e-21
Identities = 68/216 (31%), Positives = 104/216 (48%), Gaps = 5/216 (2%)
Query: 48 DETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD 107
++ N G + LRGH V +D LS S D ++R WDL + T T + GH
Sbjct: 327 EDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 108 VLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVS 167
V + S + SGS D+T +LW+ + H V CV+F PNS+ + +
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIY-AGHLADVDCVKFHPNSN--YLAT 443
Query: 168 CGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
DK V++W+ GH G + ++ SP+G AS G+D + LWDL G
Sbjct: 444 GSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503
Query: 228 YTLDG-GDIINALCFSPNRYWLCAAT-GPSIKIWDL 261
L G D I +L FSP+ + +A+ S+++WD+
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 97.1 bits (240), Expect = 2e-20
Identities = 73/216 (33%), Positives = 104/216 (48%), Gaps = 19/216 (8%)
Query: 11 LKGHNGWVTQIATTPQFPDM--ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
L+GH G + +T D +LS S D +I W L TN + Q GH++ V D
Sbjct: 338 LRGHCG---PVYSTRFLADSSGLLSCSEDMSIRYWDLG-SFTNTVLYQ----GHAYPVWD 389
Query: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
+ IS + SGS D T RLW R + GH DV V F ++ + +GS DKT
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 129 IKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLK 185
++LW+ V +T H V + FSPN + S G D+ +K+W+LA+ L
Sbjct: 450 VRLWSAQQGNSVRLFT----GHRGPVLSLAFSPNGK--YLASAGEDQRLKLWDLASGTLY 503
Query: 186 TNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL 221
GHT + ++T SPD L AS D +WD+
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 82.8 bits (203), Expect = 4e-16
Identities = 48/149 (32%), Positives = 73/149 (48%), Gaps = 8/149 (5%)
Query: 33 SASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDL 92
S S D+T +W R P R GH V V + + +GS D T+RLW
Sbjct: 401 SGSHDRTARLWSFDRT-----YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
Query: 93 TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVS 152
G + R F GH VLS+AFS + + + S D+ +KLW+ Y + H++ ++
Sbjct: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK-ELRGHTDNIT 514
Query: 153 CVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181
+ FSP+S +I S D V+VW++ N
Sbjct: 515 SLTFSPDSG--LIASASMDNSVRVWDIRN 541
Score = 82.0 bits (201), Expect = 6e-16
Identities = 74/286 (25%), Positives = 118/286 (41%), Gaps = 32/286 (11%)
Query: 31 ILSASRDKTII-MWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
+L+A D + I +W L R + P + H D++ D +
Sbjct: 282 LLAAGFDNSCIKLWSL-RSKKLKSEPHQVDVSRIHLACDILEEEDDE------------- 327
Query: 90 WDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSE 149
D GT + GH V S F +D+ ++S S D +I+ W+ LG TV + H+
Sbjct: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD-LGSFTNTVLYQGHAY 385
Query: 150 WVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCAS 209
V + SP S S D+ ++W+ + GH ++ V P+ + A+
Sbjct: 386 PVWDLDISPYSL--YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT 443
Query: 210 GGKDGQAMLWDLNEGK--HLYTLDGGDIINALCFSPN-RYWLCAATGPSIKIWDLEGKII 266
G D LW +G L+T G +++ L FSPN +Y A +K+WDL +
Sbjct: 444 GSTDKTVRLWSAQQGNSVRLFTGHRGPVLS-LAFSPNGKYLASAGEDQRLKLWDLASGTL 502
Query: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQV 312
EL+ TSL +S D + + DN VRVW +
Sbjct: 503 YKELR---------GHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 67.8 bits (164), Expect = 1e-11
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 5/121 (4%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
+ + S DKT+ +W + G R GH V + S +G++ S D L+LW
Sbjct: 441 LATGSTDKTVRLWSAQQ-----GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
DL +GT + GHT ++ S+ FS D+ I S S D ++++W+ D S SE
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSEL 555
Query: 151 V 151
V
Sbjct: 556 V 556
Score = 48.9 bits (115), Expect = 6e-06
Identities = 56/249 (22%), Positives = 101/249 (40%), Gaps = 26/249 (10%)
Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130
IS D + +G + ++LW L + H DV + + D I+ D+
Sbjct: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD---ILEEEDDEDDN 330
Query: 131 LWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIG 190
+ + + H V RF +SS ++SC D ++ W+L + + G
Sbjct: 331 AGTEMKILR------GHCGPVYSTRFLADSSG--LLSCSEDMSIRYWDLGSFTNTVLYQG 382
Query: 191 HTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALC--FSPNRYWL 248
H + + +SP ASG D A LW + L + G + + C F PN +L
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPL-RIYAGHLADVDCVKFHPNSNYL 441
Query: 249 CA-ATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLV 307
+T ++++W + V + T + SLA+S +G+ L + D +
Sbjct: 442 ATGSTDKTVRLWSAQQGNSVR------LFTGHRGP---VLSLAFSPNGKYLASAGEDQRL 492
Query: 308 RVWQVTIGT 316
++W + GT
Sbjct: 493 KLWDLASGT 501
Score = 48.9 bits (115), Expect = 6e-06
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 17/122 (13%)
Query: 13 GHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS 72
GH G V +A +P + SA D+ + +W L G + LRGH+ ++ + S
Sbjct: 466 GHRGPVLSLAFSPN-GKYLASAGEDQRLKLWDLAS-----GTLYKELRGHTDNITSLTFS 519
Query: 73 SDGQFALSGSWDGTLRLWDL-----------TTGTTTRRFVGHTKDVLSVAFSSDNRQIV 121
D S S D ++R+WD+ ++ + G +VLSV F + N +V
Sbjct: 520 PDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLV 579
Query: 122 SG 123
+G
Sbjct: 580 TG 581
Score = 28.5 bits (62), Expect = 8.2
Identities = 13/31 (41%), Positives = 16/31 (51%)
Query: 195 LNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
LNT +SPD L A+G + LW L K
Sbjct: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKK 301
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 100 bits (248), Expect = 2e-21
Identities = 87/304 (28%), Positives = 129/304 (42%), Gaps = 51/304 (16%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
L GH G V P + SA D+ I++W + D NY L+GHS V ++
Sbjct: 62 LSGHEGEVYCCKFHPN-GSTLASAGFDRLILLWNVYGDCDNYA----TLKGHSGAVMELH 116
Query: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIV-SGSRDKTI 129
++DG S S D T+ +WD TG +R GHT V S + Q+V +GS D T+
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
Query: 130 KLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189
KLW+ K +Q ++ V V F N ++ I+S G D +KVW+L KL
Sbjct: 177 KLWDIRK--KAAIQTFQNTYQVLAVTF--NDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
Query: 190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLC 249
GH + +++S +GS S D +WD+ F+P
Sbjct: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP-----------------FAPKE---- 271
Query: 250 AATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRV 309
+KI+ +G V ++ ++ S WS DG + AG D V V
Sbjct: 272 ----RCVKIF--QGN--VHNFEKNLLRCS------------WSPDGSKIAAGSADRFVYV 311
Query: 310 WQVT 313
W T
Sbjct: 312 WDTT 315
Score = 99.8 bits (247), Expect = 3e-21
Identities = 79/253 (31%), Positives = 123/253 (48%), Gaps = 20/253 (7%)
Query: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
TLKGH+G V ++ M+ SAS DKT+ +W ++ G + L+GH+ FV+
Sbjct: 104 TLKGHSGAVMELHYNTD-GSMLFSASTDKTVAVW-----DSETGERVKRLKGHTSFVNSC 157
Query: 70 VISSDG-QFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
+ G Q +GS DGT++LWD+ + F +T VL+V F+ + QI+SG D
Sbjct: 158 YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
Query: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
IK+W+ L K T H++ V+ + S S ++S D V+VW++ K
Sbjct: 217 IKVWD-LRQNKLTYTMRGHADSVTGLSLSSEGS--YLLSNAMDNTVRVWDVRPFAPKERC 273
Query: 189 IG------HTGYLNTVTVS--PDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINAL 239
+ H N + S PDGS A+G D +WD + LY L G IN +
Sbjct: 274 VKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEV 333
Query: 240 CFSPNRYWLCAAT 252
F P+ + +A+
Sbjct: 334 AFHPDEPIIISAS 346
Score = 45.4 bits (106), Expect = 6e-05
Identities = 36/133 (27%), Positives = 61/133 (45%), Gaps = 12/133 (9%)
Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR--- 60
Q L T++GH VT ++ + + +LS + D T+ +W D + +R ++
Sbjct: 224 QNKLTYTMRGHADSVTGLSLSSE-GSYLLSNAMDNTVRVW----DVRPFAPKERCVKIFQ 278
Query: 61 GHSHFVSDVVI----SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSD 116
G+ H ++ S DG +GS D + +WD T+ + GH + VAF D
Sbjct: 279 GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Query: 117 NRQIVSGSRDKTI 129
I+S S DK +
Sbjct: 339 EPIIISASSDKRL 351
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 95.9 bits (237), Expect = 4e-20
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 15/267 (5%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R LRGH + + D + +S S DG L +WD T + V++ A++
Sbjct: 48 RRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAP 107
Query: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
+ G D ++N G + + + H+ ++SC RF +S IV+ D
Sbjct: 108 SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ---IVTSSGDT 164
Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
+W++ + T GH+G + ++++SPD SG D + LWD+ +G + G
Sbjct: 165 TCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTG 224
Query: 233 G-DIINALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
INA+ F PN Y + + + +++DL QE++ S TS+A
Sbjct: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRA-------DQELLLYSHDNIICGITSVA 277
Query: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317
+S G+ L AGY D VW G R
Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDR 304
Score = 80.1 bits (196), Expect = 2e-15
Identities = 81/318 (25%), Positives = 136/318 (42%), Gaps = 33/318 (10%)
Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRG 61
QM R TL+GH + +I D +++SAS+D +I+W + IP R
Sbjct: 44 QMRTRRTLRGH---LAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLR---- 96
Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG----TTTRRFVGHTKDVLSVAFSSDN 117
S +V + G + G D +++L T +R GHT LS D+
Sbjct: 97 -SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHT-GYLSCCRFLDD 154
Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
QIV+ S D T LW+ + + T HS V + SP+ + +C D K+W
Sbjct: 155 SQIVTSSGDTTCALWD-IETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGAC--DASSKLW 211
Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-- 235
++ + + + GH +N V+ P+G A+G D L+DL + L +I
Sbjct: 212 DIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIIC 271
Query: 236 -INALCFSPN-RYWLCAATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
I ++ FS + R L + +WD L+G + V++ + + L +
Sbjct: 272 GITSVAFSKSGRLLLAGYDDFNCNVWDTLKGD------RAGVLA----GHDNRVSCLGVT 321
Query: 293 ADGQTLFAGYTDNLVRVW 310
DG + G D+ +R+W
Sbjct: 322 DDGMAVATGSWDSFLRIW 339
Score = 75.5 bits (184), Expect = 6e-14
Identities = 69/252 (27%), Positives = 107/252 (42%), Gaps = 14/252 (5%)
Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
+ WV A P + + D ++ L E N + R L GH+ ++S D
Sbjct: 97 SSWVMTCAYAPS-GNYVACGGLDNICSIYNLKTREGNVRV-SRELPGHTGYLSCCRFLDD 154
Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
Q S S D T LWD+ T T F GH+ DV+S++ S D R VSG+ D + KLW+
Sbjct: 155 SQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI 213
Query: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGH 191
G+C+ + H ++ V F PN + D ++++L + L +H
Sbjct: 214 RDGMCRQSF--TGHVSDINAVSFFPNGY--AFATGSDDATCRLFDLRADQELLLYSHDNI 269
Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
+ +V S G L +G D +WD +G L G D C + A
Sbjct: 270 ICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHD-NRVSCLGVTDDGMAVA 328
Query: 252 TG---PSIKIWD 260
TG ++IW+
Sbjct: 329 TGSWDSFLRIWN 340
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 95.5 bits (236), Expect = 5e-20
Identities = 82/317 (25%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 597 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 654
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 655 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 713
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL- 221
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 714 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 222 --NEGKHL----YTLDGGD-------IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268
NE K + + L+ D I+ +S + + A I ++D+ ++
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 833
Query: 269 ELKQ---------------------------EVISTSSKAEPPQCTS-LAW------SAD 294
E+ E+ +T S+++ C L+W S D
Sbjct: 834 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 893
Query: 295 GQTLFAGYTDNLVRVWQ 311
G + D +R+W+
Sbjct: 894 GSSFLTSSDDQTIRLWE 910
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 1018 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1070
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 1071 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1129
Query: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 1130 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1186
Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
PDG + S G G W++ G+ T
Sbjct: 1187 PDGKMLISAG--GYIKWWNVVTGESSQT 1212
Score = 68.2 bits (165), Expect = 9e-12
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 964 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1023
Query: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 1024 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1077
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 1078 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1137
Query: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 1138 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1193
Query: 300 AGYTDNLVRVWQVTIG 315
+ ++ W V G
Sbjct: 1194 S--AGGYIKWWNVVTG 1207
Score = 53.5 bits (127), Expect = 2e-07
Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
++ + S D + +W L + E + + GH++ V+ S D + S S DGTL+L
Sbjct: 715 LLATGSSDCFLKLWDLNQKEC-----RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKL 769
Query: 90 WDLTTGT-----TTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136
WD T+ ++F + +D V ++S+D +I+ +++K I L++
Sbjct: 770 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 828
Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196
H + FSP + ++ + V++WN + + GH +++
Sbjct: 829 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVH 886
Query: 197 TVTVSPDGSLCASGGKDGQAMLWD 220
V SPDGS + D LW+
Sbjct: 887 GVMFSPDGSSFLTSSDDQTIRLWE 910
Score = 45.4 bits (106), Expect = 6e-05
Identities = 48/248 (19%), Positives = 96/248 (38%), Gaps = 24/248 (9%)
Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
RGH +V V+ S DG L+ S D T+RLW+ T + K + V F +
Sbjct: 879 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVM 936
Query: 120 IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
+++ + ++L N G Y + + VSC SP+ I + +++
Sbjct: 937 VLAVDHIRRLQLINGRTGQIDYLTEAQ-----VSCCCLSPHLQ--YIAFGDENGAIEILE 989
Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238
L N ++ + H + + + D S D + +W+ K ++ + +
Sbjct: 990 LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKD 1049
Query: 239 LCFSPNRYWLCAATGPSIKIWDL------------EGKIIVDELKQEVISTSSKAEPPQC 286
N L + ++K+W++ +G ++ ++ + SS +
Sbjct: 1050 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADK-- 1107
Query: 287 TSLAWSAD 294
T+ WS D
Sbjct: 1108 TAKIWSFD 1115
Score = 40.0 bits (92), Expect = 0.003
Identities = 23/79 (29%), Positives = 33/79 (41%)
Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
GH + S A+ + LW+ + + GH V V FS D
Sbjct: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897
Query: 121 VSGSRDKTIKLWNTLGVCK 139
++ S D+TI+LW T VCK
Sbjct: 898 LTSSDDQTIRLWETKKVCK 916
Score = 37.4 bits (85), Expect = 0.018
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 1123 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1179
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 1180 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 95.5 bits (236), Expect = 5e-20
Identities = 82/317 (25%), Positives = 135/317 (42%), Gaps = 51/317 (16%)
Query: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 586 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
Query: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 702
Query: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL- 221
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 222 --NEGKHL----YTLDGGD-------IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVD 268
NE K + + L+ D I+ +S + + A I ++D+ ++
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLG 822
Query: 269 ELKQ---------------------------EVISTSSKAEPPQCTS-LAW------SAD 294
E+ E+ +T S+++ C L+W S D
Sbjct: 823 EIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPD 882
Query: 295 GQTLFAGYTDNLVRVWQ 311
G + D +R+W+
Sbjct: 883 GSSFLTSSDDQTIRLWE 899
Score = 79.7 bits (195), Expect = 3e-15
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 1007 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1059
Query: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 1060 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1118
Query: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 1119 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1175
Query: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
PDG + S G G W++ G+ T
Sbjct: 1176 PDGKMLISAG--GYIKWWNVVTGESSQT 1201
Score = 68.2 bits (165), Expect = 9e-12
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 953 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 1012
Query: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 1013 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1066
Query: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 1067 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1126
Query: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 1127 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1182
Query: 300 AGYTDNLVRVWQVTIG 315
+ ++ W V G
Sbjct: 1183 S--AGGYIKWWNVVTG 1196
Score = 53.5 bits (127), Expect = 2e-07
Identities = 47/204 (23%), Positives = 89/204 (43%), Gaps = 21/204 (10%)
Query: 30 MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRL 89
++ + S D + +W L + E + + GH++ V+ S D + S S DGTL+L
Sbjct: 704 LLATGSSDCFLKLWDLNQKEC-----RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKL 758
Query: 90 WDLTTGT-----TTRRFVGHTKD--------VLSVAFSSDNRQIVSGSRDKTIKLWNTLG 136
WD T+ ++F + +D V ++S+D +I+ +++K I L++
Sbjct: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHT 817
Query: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196
H + FSP + ++ + V++WN + + GH +++
Sbjct: 818 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY--CVELWNTDSRSKVADCRGHLSWVH 875
Query: 197 TVTVSPDGSLCASGGKDGQAMLWD 220
V SPDGS + D LW+
Sbjct: 876 GVMFSPDGSSFLTSSDDQTIRLWE 899
Score = 45.4 bits (106), Expect = 6e-05
Identities = 48/248 (19%), Positives = 96/248 (38%), Gaps = 24/248 (9%)
Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
RGH +V V+ S DG L+ S D T+RLW+ T + K + V F +
Sbjct: 868 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVM 925
Query: 120 IVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
+++ + ++L N G Y + + VSC SP+ I + +++
Sbjct: 926 VLAVDHIRRLQLINGRTGQIDYLTEAQ-----VSCCCLSPHLQ--YIAFGDENGAIEILE 978
Query: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINA 238
L N ++ + H + + + D S D + +W+ K ++ + +
Sbjct: 979 LVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKD 1038
Query: 239 LCFSPNRYWLCAATGPSIKIWDL------------EGKIIVDELKQEVISTSSKAEPPQC 286
N L + ++K+W++ +G ++ ++ + SS +
Sbjct: 1039 FRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADK-- 1096
Query: 287 TSLAWSAD 294
T+ WS D
Sbjct: 1097 TAKIWSFD 1104
Score = 40.0 bits (92), Expect = 0.003
Identities = 23/79 (29%), Positives = 33/79 (41%)
Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
GH + S A+ + LW+ + + GH V V FS D
Sbjct: 827 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 886
Query: 121 VSGSRDKTIKLWNTLGVCK 139
++ S D+TI+LW T VCK
Sbjct: 887 LTSSDDQTIRLWETKKVCK 905
Score = 37.4 bits (85), Expect = 0.018
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 1112 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1168
Query: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 1169 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 93.6 bits (231), Expect = 2e-19
Identities = 83/310 (26%), Positives = 140/310 (45%), Gaps = 29/310 (9%)
Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALR----GH 62
L+ + H V+ ++ P D+++S D+ +WK+ G+P+ + GH
Sbjct: 344 LKNIFRLHELPVSCVSMQPH-KDILVSCGEDR---LWKVL------GLPKCNVLLTGFGH 393
Query: 63 SHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
+ ++SD G + S D T++LWDL G F GH++ V S + S + S
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVAS 453
Query: 123 GSRDKTIKLWNTLGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLAN 181
S DKT K+W+ C+ T+ H++ V+ + F P SN ++ S DK + +W+
Sbjct: 454 SSLDKTSKIWDVNSERCRCTLY--GHTDSVNSIEFFP-FSNTLLTSSA-DKTLSIWDART 509
Query: 182 CKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD-GGDIINALC 240
+ + GH +N P G + AS G LWD + + ++D G N +
Sbjct: 510 GICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVN 569
Query: 241 FSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFA 300
F + L A+G G I + +LK I E + ++ +S DG+ LF+
Sbjct: 570 FDSSGRVLAQASG--------NGVIHLLDLKSGEIHKLMGHE-NEAHTVVFSHDGEILFS 620
Query: 301 GYTDNLVRVW 310
G +D VR W
Sbjct: 621 GGSDGTVRTW 630
Score = 53.5 bits (127), Expect = 2e-07
Identities = 41/168 (24%), Positives = 66/168 (39%), Gaps = 49/168 (29%)
Query: 8 RGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVS 67
R TL GH V I P F + +L++S DKT+ +W + GI +++L GH H ++
Sbjct: 471 RCTLYGHTDSVNSIEFFP-FSNTLLTSSADKTLSIW-----DARTGICEQSLYGHMHSIN 524
Query: 68 DVVIS------------------------------------------SDGQFALSGSWDG 85
D + S G+ S +G
Sbjct: 525 DAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNG 584
Query: 86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
+ L DL +G + +GH + +V FS D + SG D T++ W+
Sbjct: 585 VIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 93.2 bits (230), Expect = 3e-19
Identities = 70/267 (26%), Positives = 119/267 (44%), Gaps = 15/267 (5%)
Query: 56 QRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
+R LRGH + + +D + +S S DG L +WD T + V++ A++
Sbjct: 48 RRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAP 107
Query: 116 DNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
+ G D +++ G + + + H+ ++SC RF N II S G D
Sbjct: 108 SGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFL--DDNQIITSSG-DT 164
Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG 232
+W++ + GH+G + +++++PDG SG D LWD+ + T G
Sbjct: 165 TCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIG 224
Query: 233 GDI-INALCFSPNRY-WLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
+ INA+ F PN Y + + + +++DL QE++ S TS+A
Sbjct: 225 HESDINAVAFFPNGYAFTTGSDDATCRLFDLRA-------DQELLMYSHDNIICGITSVA 277
Query: 291 WSADGQTLFAGYTDNLVRVWQVTIGTR 317
+S G+ L AGY D +W G R
Sbjct: 278 FSRSGRLLLAGYDDFNCNIWDAMKGDR 304
Score = 80.9 bits (198), Expect = 1e-15
Identities = 80/318 (25%), Positives = 134/318 (42%), Gaps = 33/318 (10%)
Query: 4 QMTLRGTLKGHNGWVTQIATTPQFPD--MILSASRDKTIIMWKLTRDETNYGIPQRALRG 61
QM R TL+GH + +I D +++SAS+D +I+W + IP R
Sbjct: 44 QMRTRRTLRGH---LAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLR---- 96
Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTG----TTTRRFVGHTKDVLSVAFSSDN 117
S +V + G F G D ++ L T +R GHT + F DN
Sbjct: 97 -SSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDN 155
Query: 118 RQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
QI++ S D T LW+ + + TV HS V + +P+ + +C D +K+W
Sbjct: 156 -QIITSSGDTTCALWD-IETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGAC--DASIKLW 211
Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-- 235
++ + + IGH +N V P+G +G D L+DL + L +I
Sbjct: 212 DVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIIC 271
Query: 236 -INALCFS-PNRYWLCAATGPSIKIWD-LEGKIIVDELKQEVISTSSKAEPPQCTSLAWS 292
I ++ FS R L + IWD ++G + V++ + + L +
Sbjct: 272 GITSVAFSRSGRLLLAGYDDFNCNIWDAMKGD------RAGVLA----GHDNRVSCLGVT 321
Query: 293 ADGQTLFAGYTDNLVRVW 310
DG + G D+ +++W
Sbjct: 322 DDGMAVATGSWDSFLKIW 339
Score = 80.5 bits (197), Expect = 2e-15
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 14/252 (5%)
Query: 15 NGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSD 74
+ WV A P + + D ++ L E N + R L GH+ ++S D
Sbjct: 97 SSWVMTCAYAPS-GNFVACGGLDNICSIYSLKTREGNVRV-SRELPGHTGYLSCCRFLDD 154
Query: 75 GQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT 134
Q ++ S D T LWD+ TG T F GH+ DV+S++ + D R VSG+ D +IKLW+
Sbjct: 155 NQI-ITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDV 213
Query: 135 L-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK--LKTNHIGH 191
+C+ T H ++ V F PN + D ++++L + L +H
Sbjct: 214 RDSMCRQTF--IGHESDINAVAFFPNGY--AFTTGSDDATCRLFDLRADQELLMYSHDNI 269
Query: 192 TGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAA 251
+ +V S G L +G D +WD +G L G D C + A
Sbjct: 270 ICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHD-NRVSCLGVTDDGMAVA 328
Query: 252 TG---PSIKIWD 260
TG +KIW+
Sbjct: 329 TGSWDSFLKIWN 340
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 91.3 bits (225), Expect = 1e-18
Identities = 59/223 (26%), Positives = 107/223 (47%), Gaps = 19/223 (8%)
Query: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD--------VLSVA 112
G V S DGQ+ ++GS DG + +W+ TTG + +D VL +
Sbjct: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
Query: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
FS D + +G++D IK+W + +HS+ V+C+ FS +SS I+S +D+
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ--ILSASFDQ 329
Query: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL------NEGKH 226
+++ L + K GH+ ++N T + DG S DG +W++ N K
Sbjct: 330 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 389
Query: 227 LYTLDGGDI-INALCFSPN--RYWLCAATGPSIKIWDLEGKII 266
L + G DI +N++ P +++ ++ I +++G+I+
Sbjct: 390 LGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIV 432
Score = 64.7 bits (156), Expect = 1e-10
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 4/105 (3%)
Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88
+M+ + ++D I +WK+ + +R R HS V+ + S D LS S+D T+R
Sbjct: 277 EMLATGAQDGKIKVWKIQSGQCL----RRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 332
Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
+ L +G T + F GH+ V F+ D I+S S D T+K+WN
Sbjct: 333 IHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
Score = 58.5 bits (140), Expect = 7e-09
Identities = 59/222 (26%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
LR + H+ VT ++ + ILSAS D+TI + L +T + RGHS FV
Sbjct: 299 LRRFERAHSKGVTCLSFSKD-SSQILSASFDQTIRIHGLKSGKT-----LKEFRGHSSFV 352
Query: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDVLSVAFSSDN-RQ 119
++ + DG + +S S DGT+++W++ T + F G V SV N
Sbjct: 353 NEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412
Query: 120 IVSGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
V +R T+ + N G V ++ ++V C SP I G D ++ +
Sbjct: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCA-LSPRGE--WIYCVGEDFVLYCF 469
Query: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
+ KL+ H + + P +L A+ +DG LW
Sbjct: 470 STVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 29.3 bits (64), Expect = 4.8
Identities = 18/67 (26%), Positives = 26/67 (38%), Gaps = 5/67 (7%)
Query: 254 PSIKIWDLEGKIIVDELKQEVISTSSK-----AEPPQCTSLAWSADGQTLFAGYTDNLVR 308
P + I GK V ++++E T + +S DGQ L G D +
Sbjct: 180 PGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIE 239
Query: 309 VWQVTIG 315
VW T G
Sbjct: 240 VWNFTTG 246
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 90.1 bits (222), Expect = 2e-18
Identities = 66/244 (27%), Positives = 115/244 (47%), Gaps = 22/244 (9%)
Query: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSG-SWDGTLRL 89
+++AS DKT+ W L + + + + F+ S DG++ +SG D + +
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVR------YDTFIVSCKFSPDGKYVVSGFDVDHGICI 213
Query: 90 WDLTTGTTTRRFVGH-TKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHS 148
D TT H T+ + S F D++++ S S D+ IK+W+ ++HS
Sbjct: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
Query: 149 EWVS--CVRFSPNSSNPIIVSCGWDKLVKVWNL-----ANC-KLKTNHIGHTGYLNTVTV 200
+S C FS + + + WDK +K+WN+ NC T GH G +++
Sbjct: 274 NAISNCCFTFSGH----FLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHF 329
Query: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYW-LCAATGPSIKI 258
+ D S SGG D +WD+ EG +L G D + + S N+ W L A+ ++++
Sbjct: 330 ARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRL 389
Query: 259 WDLE 262
W++E
Sbjct: 390 WNIE 393
Score = 85.1 bits (209), Expect = 7e-17
Identities = 73/274 (26%), Positives = 123/274 (44%), Gaps = 21/274 (7%)
Query: 54 IPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTK-DVLSVA 112
IP + L GH H VS D LSGS+D T++LWD G+ R F K V+ +
Sbjct: 93 IPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECS 152
Query: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
+ D+ ++++ S DKT++ W+ L K + + VSC +FSP+ V G+D
Sbjct: 153 ITGDSSRVIAASYDKTVRAWD-LETGKLLWKVRYDTFIVSC-KFSPDGK---YVVSGFDV 207
Query: 173 -----LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
++ N+ + +H HT + + PD AS D +WD+ L
Sbjct: 208 DHGICIMDAENITTVSVIKDH--HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATL 265
Query: 228 YTLD--GGDIINALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQ-EVISTSSKAEP 283
T+ + I+ CF+ + ++LC ++ ++KIW++ E + T +
Sbjct: 266 LTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVH----TGEFRNCGACVTLMQGHE 321
Query: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
+S ++ D L +G D V +W V G R
Sbjct: 322 GSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYR 355
Score = 72.4 bits (176), Expect = 5e-13
Identities = 41/134 (30%), Positives = 69/134 (51%), Gaps = 2/134 (1%)
Query: 1 MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-TRDETNYGIPQRAL 59
+T Q TL K H+ ++ T + ++S DK + +W + T + N G +
Sbjct: 259 VTSQATLLTITKAHSNAISNCCFTFS-GHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLM 317
Query: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
+GH VS + D F +SG +D T+ +WD+ G GH V+ VA S++ +
Sbjct: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
Query: 120 IVSGSRDKTIKLWN 133
I+S S+D+T++LWN
Sbjct: 378 ILSASKDRTMRLWN 391
Score = 68.9 bits (167), Expect = 5e-12
Identities = 44/170 (25%), Positives = 77/170 (45%), Gaps = 12/170 (7%)
Query: 62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-GHTKDVLSVAFSSDNRQI 120
H+ ++ D Q S S D +++WD+T+ T H+ + + F+ +
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 121 VSGSRDKTIKLWNT-------LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173
+ S DK +K+WN G C +Q H VS F+ +SS ++S G+D+
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQ--GHEGSVSSCHFARDSS--FLISGGFDRT 344
Query: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223
V +W++A K + GH ++ V +S + S KD LW++ E
Sbjct: 345 VAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEE 394
Score = 47.0 bits (110), Expect = 2e-05
Identities = 25/82 (30%), Positives = 46/82 (56%), Gaps = 6/82 (7%)
Query: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
++GH G V+ ++S D+T+ +W + G + +L+GH+ +V DV
Sbjct: 317 MQGHEGSVSSCHFARD-SSFLISGGFDRTVAIWDVAE-----GYRKLSLKGHNDWVMDVA 370
Query: 71 ISSDGQFALSGSWDGTLRLWDL 92
IS++ ++ LS S D T+RLW++
Sbjct: 371 ISNNKKWILSASKDRTMRLWNI 392
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 89.7 bits (221), Expect = 3e-18
Identities = 69/239 (28%), Positives = 109/239 (45%), Gaps = 18/239 (7%)
Query: 26 QFPDM-ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD 84
Q+ D I+S RD TI +W E +R L GH+ V + + D + ++GS D
Sbjct: 274 QYDDQKIVSGLRDNTIKIWDKNTLEC-----KRILTGHTGSV--LCLQYDERVIITGSSD 326
Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD 144
T+R+WD+ TG + H + VL + F +N +V+ S+D++I +W+ T++
Sbjct: 327 STVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRR 384
Query: 145 --ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202
H V+ V F + IVS D+ +KVWN + C+ GH +
Sbjct: 385 VLVGHRAAVNVVDF----DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK--RGIACLQY 438
Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261
L SG D LWD+ G L L+G + + N+ + A IK+WDL
Sbjct: 439 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 497
Score = 55.1 bits (131), Expect = 8e-08
Identities = 45/136 (33%), Positives = 64/136 (47%), Gaps = 23/136 (16%)
Query: 10 TLKGHNGWVTQIATTPQFPD-MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
TL GH + + Q+ D +++S S D TI +W + G R L GH V
Sbjct: 425 TLNGHKRGIACL----QYRDRLVVSGSSDNTIRLWDI-----ECGACLRVLEGHEELVR- 474
Query: 69 VVISSDGQFALSGSWDGTLRLWDLT--------TGT-TTRRFVGHTKDVLSVAFSSDNRQ 119
I D + +SG++DG +++WDL GT R V H+ V + F D Q
Sbjct: 475 -CIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQ 531
Query: 120 IVSGSRDKTIKLWNTL 135
IVS S D TI +W+ L
Sbjct: 532 IVSSSHDDTILIWDFL 547
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 89.7 bits (221), Expect = 3e-18
Identities = 69/239 (28%), Positives = 109/239 (45%), Gaps = 18/239 (7%)
Query: 26 QFPDM-ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWD 84
Q+ D I+S RD TI +W E +R L GH+ V + + D + ++GS D
Sbjct: 310 QYDDQKIVSGLRDNTIKIWDKNTLEC-----KRILTGHTGSV--LCLQYDERVIITGSSD 362
Query: 85 GTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD 144
T+R+WD+ TG + H + VL + F +N +V+ S+D++I +W+ T++
Sbjct: 363 STVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRR 420
Query: 145 --ESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202
H V+ V F + IVS D+ +KVWN + C+ GH +
Sbjct: 421 VLVGHRAAVNVVDF----DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK--RGIACLQY 474
Query: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDL 261
L SG D LWD+ G L L+G + + N+ + A IK+WDL
Sbjct: 475 RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDL 533
Score = 55.1 bits (131), Expect = 8e-08
Identities = 45/136 (33%), Positives = 64/136 (47%), Gaps = 23/136 (16%)
Query: 10 TLKGHNGWVTQIATTPQFPD-MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
TL GH + + Q+ D +++S S D TI +W + G R L GH V
Sbjct: 461 TLNGHKRGIACL----QYRDRLVVSGSSDNTIRLWDI-----ECGACLRVLEGHEELVR- 510
Query: 69 VVISSDGQFALSGSWDGTLRLWDLT--------TGT-TTRRFVGHTKDVLSVAFSSDNRQ 119
I D + +SG++DG +++WDL GT R V H+ V + F D Q
Sbjct: 511 -CIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF--DEFQ 567
Query: 120 IVSGSRDKTIKLWNTL 135
IVS S D TI +W+ L
Sbjct: 568 IVSSSHDDTILIWDFL 583
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 89.4 bits (220), Expect = 4e-18
Identities = 66/239 (27%), Positives = 109/239 (45%), Gaps = 17/239 (7%)
Query: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88
+ I+S RD +I +W T E + L GH+ V + + D + ++GS D T+R
Sbjct: 251 EKIISGLRDNSIKIWDKTSLEC-----LKVLTGHTGSV--LCLQYDERVIVTGSSDSTVR 303
Query: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQD--ES 146
+WD+ TG + H + VL + FS N +V+ S+D++I +W+ T++
Sbjct: 304 VWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVG 361
Query: 147 HSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSL 206
H V+ V F + IVS D+ +KVW+ + C+ GH + L
Sbjct: 362 HRAAVNVVDF----DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK--RGIACLQYRDRL 415
Query: 207 CASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKI 265
SG D LWD+ G L L+G + + N+ + A IK+WDL+ +
Sbjct: 416 VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAAL 474
Score = 77.8 bits (190), Expect = 1e-14
Identities = 64/244 (26%), Positives = 115/244 (47%), Gaps = 27/244 (11%)
Query: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW- 132
D + +SG D ++++WD T+ + GHT VL + + D R IV+GS D T+++W
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWD 306
Query: 133 -NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANC---KLKTNH 188
NT V + H+E V +RF SN ++V+C D+ + VW++A+ L+
Sbjct: 307 VNTGEVLNTLIH---HNEAVLHLRF----SNGLMVTCSKDRSIAVWDMASATDITLRRVL 359
Query: 189 IGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWL 248
+GH +N V + ASG D +W + + + TL+G A +R +
Sbjct: 360 VGHRAAVNVVDFDDKYIVSASG--DRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVV 417
Query: 249 CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308
++ +I++WD+E + L+ E +C D + + +G D ++
Sbjct: 418 SGSSDNTIRLWDIECGACLRVLE-------GHEELVRCIRF----DNKRIVSGAYDGKIK 466
Query: 309 VWQV 312
VW +
Sbjct: 467 VWDL 470
Score = 55.8 bits (133), Expect = 5e-08
Identities = 46/149 (30%), Positives = 70/149 (46%), Gaps = 24/149 (16%)
Query: 10 TLKGHNGWVTQIATTPQFPD-MILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
TL GH + + Q+ D +++S S D TI +W + G R L GH V
Sbjct: 398 TLNGHKRGIACL----QYRDRLVVSGSSDNTIRLWDI-----ECGACLRVLEGHEELVR- 447
Query: 69 VVISSDGQFALSGSWDGTLRLWDL---------TTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
I D + +SG++DG +++WDL + R V H+ V + F D Q
Sbjct: 448 -CIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQ 504
Query: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHS 148
I+S S D TI +W+ L V + Q+E+ S
Sbjct: 505 IISSSHDDTILIWDFLNV-PPSAQNETRS 532
Score = 42.4 bits (98), Expect = 5e-04
Identities = 43/204 (21%), Positives = 84/204 (41%), Gaps = 23/204 (11%)
Query: 116 DNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVK 175
D+ +I+SG RD +IK+W+ + V H+ V C+++ +IV+ D V+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLT-GHTGSVLCLQYDER----VIVTGSSDSTVR 303
Query: 176 VWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL----YTLD 231
VW++ ++ I H + + S L + KD +WD+ + +
Sbjct: 304 VWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVG 361
Query: 232 GGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAW 291
+N + F ++Y + A+ +IK+W V L + C
Sbjct: 362 HRAAVNVVDFD-DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-------CLQYR- 412
Query: 292 SADGQTLFAGYTDNLVRVWQVTIG 315
+ + +G +DN +R+W + G
Sbjct: 413 ---DRLVVSGSSDNTIRLWDIECG 433
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,948,720
Number of Sequences: 37866
Number of extensions: 555517
Number of successful extensions: 4453
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 257
Number of HSP's successfully gapped in prelim test: 84
Number of HSP's that attempted gapping in prelim test: 1133
Number of HSP's gapped (non-prelim): 1551
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.