Search of human proteins with 50959191

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50959191 rho guanine nucleotide exchange factor 5 [Homo
sapiens]
         (1597 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]  3233   0.0  
gi|51172610 Rho guanine nucleotide exchange factor (GEF) 5-like ...   961   0.0  
gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Hom...   494   e-139
gi|166197688 neuronal guanine nucleotide exchange factor isoform...   372   e-102
gi|166197690 neuronal guanine nucleotide exchange factor isoform...   370   e-102
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]            293   7e-79
gi|194473700 Src homology 3 domain-containing guanine nucleotide...   288   4e-77
gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]             270   1e-71
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]    88   6e-17
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    84   1e-15
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    84   1e-15
gi|24797153 faciogenital dysplasia protein [Homo sapiens]              83   2e-15
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    82   4e-15
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    82   4e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    82   4e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    81   7e-15
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...    80   2e-14
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...    80   2e-14
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        80   2e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                79   3e-14
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...    78   6e-14
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   75   4e-13
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   75   4e-13
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   75   4e-13
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    75   4e-13
gi|116284392 mucin 2 precursor [Homo sapiens]                          74   9e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    74   1e-12
gi|210032580 SET domain containing 1B [Homo sapiens]                   74   1e-12
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    74   1e-12
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...    73   3e-12

>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 3233 bits (8383), Expect = 0.0
 Identities = 1597/1597 (100%), Positives = 1597/1597 (100%)

Query: 1    MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ 60
            MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ
Sbjct: 1    MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ 60

Query: 61   QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA 120
            QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA
Sbjct: 61   QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA 120

Query: 121  PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT 180
            PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT
Sbjct: 121  PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT 180

Query: 181  RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF 240
            RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF
Sbjct: 181  RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF 240

Query: 241  RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL 300
            RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL
Sbjct: 241  RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL 300

Query: 301  NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE 360
            NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE
Sbjct: 301  NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE 360

Query: 361  DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD 420
            DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD
Sbjct: 361  DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD 420

Query: 421  LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEID 480
            LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEID
Sbjct: 421  LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEID 480

Query: 481  QNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVA 540
            QNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVA
Sbjct: 481  QNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVA 540

Query: 541  FPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQ 600
            FPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQ
Sbjct: 541  FPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQ 600

Query: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
            HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS
Sbjct: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660

Query: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
            ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR
Sbjct: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720

Query: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS 780
            IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS
Sbjct: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS 780

Query: 781  DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLP 840
            DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLP
Sbjct: 781  DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLP 840

Query: 841  PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPP 900
            PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPP
Sbjct: 841  PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPP 900

Query: 901  ATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHP 960
            ATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHP
Sbjct: 901  ATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHP 960

Query: 961  EAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSG 1020
            EAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSG
Sbjct: 961  EAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSG 1020

Query: 1021 QAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMG 1080
            QAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMG
Sbjct: 1021 QAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMG 1080

Query: 1081 GFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESY 1140
            GFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESY
Sbjct: 1081 GFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESY 1140

Query: 1141 LQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHF 1200
            LQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHF
Sbjct: 1141 LQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHF 1200

Query: 1201 QLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDF 1260
            QLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDF
Sbjct: 1201 QLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDF 1260

Query: 1261 RRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL 1320
            RRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL
Sbjct: 1261 RRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL 1320

Query: 1321 KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECK 1380
            KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECK
Sbjct: 1321 KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECK 1380

Query: 1381 IFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVF 1440
            IFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVF
Sbjct: 1381 IFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVF 1440

Query: 1441 DHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMP 1500
            DHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMP
Sbjct: 1441 DHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMP 1500

Query: 1501 REELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGW 1560
            REELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGW
Sbjct: 1501 REELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGW 1560

Query: 1561 FPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA 1597
            FPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA
Sbjct: 1561 FPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA 1597


>gi|51172610 Rho guanine nucleotide exchange factor (GEF) 5-like
           [Homo sapiens]
          Length = 484

 Score =  961 bits (2484), Expect = 0.0
 Identities = 474/478 (99%), Positives = 476/478 (99%)

Query: 1   MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ 60
           MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ
Sbjct: 1   MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQ 60

Query: 61  QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA 120
           QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA
Sbjct: 61  QSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGRQARTLA 120

Query: 121 PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT 180
           PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT
Sbjct: 121 PPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQT 180

Query: 181 RYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGF 240
           RYYSPCEEHPAETNQNEG+ESGTIRQGEELP EELQESQGLLHPQEVQVLEEQGQQEAGF
Sbjct: 181 RYYSPCEEHPAETNQNEGAESGTIRQGEELPSEELQESQGLLHPQEVQVLEEQGQQEAGF 240

Query: 241 RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL 300
           RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL
Sbjct: 241 RGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGL 300

Query: 301 NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE 360
           NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE
Sbjct: 301 NDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQE 360

Query: 361 DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD 420
           DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD
Sbjct: 361 DHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCD 420

Query: 421 LFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKE 478
           LFPGASYL+TQIPGTQTESRAEELSPAALSP LEPIRCSHQPISLLGSFLTEESPDKE
Sbjct: 421 LFPGASYLVTQIPGTQTESRAEELSPAALSPLLEPIRCSHQPISLLGSFLTEESPDKE 478


>gi|40255149 Rho guanine nucleotide exchange factor (GEF) 19 [Homo
            sapiens]
          Length = 802

 Score =  494 bits (1271), Expect = e-139
 Identities = 320/750 (42%), Positives = 425/750 (56%), Gaps = 55/750 (7%)

Query: 885  WTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS-----PGMAFSNMTNFLCPSSPTT 939
            W++  PA      WP +   S    TS     S        PG           P +   
Sbjct: 65   WSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQ---------PPALEG 115

Query: 940  PWTPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASG-------PGRSPVGQARQPE 992
            PW+P    P  +   G SE   A  +  + +     G          PG+    QA   E
Sbjct: 116  PWSPRHTQPQRRASHG-SEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTE 174

Query: 993  KP-------SHLHLE-------KASSWPHRRDSGRPPG-DSSGQAVAPSEGANKHKGWSR 1037
            +P       + + LE        AS    R  S    G +S+ +A+    G    +    
Sbjct: 175  EPRVELSGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKA 234

Query: 1038 QGLRRPSILPEGSSDSRGPAVEKHPGP--SDTVVFREKKPKEVMGGFSRRCSKLINSSQL 1095
             G+   S+   G   SR    +   G      +  +E+ P        RR S+ + +S +
Sbjct: 235  SGMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNS-V 293

Query: 1096 LYQEYSDVVLNKEIQSQQRLESLSETPGPSS------PRQPRKALVSSESY-LQRLSMAS 1148
            LYQEYSDV   +E++ QQR E   E PG  +      P  PR  L  S S+  QR +  S
Sbjct: 294  LYQEYSDVASARELRRQQREE---EGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGS 350

Query: 1149 SGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRA 1208
            + SLWQ+IP VR S VL +++  D KLQE KFELI SEASY+ SL++AV HF  S  L  
Sbjct: 351  TFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSE 410

Query: 1209 TLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYV 1268
             L  Q+ QWLFS+L +V+  S  FL DLE+  E ++  F VCDVVL+H P FRRVYLPYV
Sbjct: 411  CLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYV 470

Query: 1269 TNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNIL 1328
            TNQ YQERT+Q L+  N  F  +L +LE  PVCQRL L SFLILPFQRITRLK+L++NIL
Sbjct: 471  TNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENIL 530

Query: 1329 KRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQS 1388
            KRT  GS +E  ATKA +AL++L+++CN +VQSM+RTEELI+LS+KI FE KIFPLISQ+
Sbjct: 531  KRTAQGSEDEDMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQA 590

Query: 1389 RWLVKSGELTAL-EFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSS 1447
            RWLV+ GEL  L    A+P  + KL+++ V+LHLFNDCLLLSR +E  +F VF HA  + 
Sbjct: 591  RWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAE 650

Query: 1448 IRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISAL--AMPREELD 1505
            ++     +KL G   ++F L L    Q  + +FL R  T+SEK RWISAL  + P+E+ +
Sbjct: 651  LQVRDLSLKLQGIPGHVFLLQLLHG-QHMKHQFLLRARTESEKQRWISALCPSSPQEDKE 709

Query: 1506 LL-ECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQ 1564
            ++ E  + PQVQC+R YK    DEL LEK D++ V   +SDGWLEGVRL+DGE+GW P  
Sbjct: 710  VISEGEDCPQVQCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQA 769

Query: 1565 QVEFISNPEVRAQNLKEAHRVKTAKLQLVE 1594
             VE IS+   R +NL+E  RV +A  +L E
Sbjct: 770  YVEEISSLSARLRNLRENKRVTSATSKLGE 799


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
            [Homo sapiens]
          Length = 710

 Score =  372 bits (955), Expect = e-102
 Identities = 238/618 (38%), Positives = 336/618 (54%), Gaps = 39/618 (6%)

Query: 1001 KASSWPHRRDSGRPPGDSSGQAVAPSEGANKHKGWSRQGLRRPSILPE---------GSS 1051
            KA   P R  S       +G++V  +E    +  WSR    R ++  +          S+
Sbjct: 76   KARDNPERNASCLADSQDNGKSV--NEPLTLNIPWSRMPPCRTAMQTDPGAQEMSESSST 133

Query: 1052 DSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQS 1111
               G   E+ P  +D+     +  + +    +     LI    LLYQEY D    +EI++
Sbjct: 134  PGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIET 193

Query: 1112 --QQRLESLSETPG-PSSPRQPRKALVSSESY----------LQRLSMASSG----SLWQ 1154
              QQ  E    T G P+S   P +     E            L ++ + S+     +LWQ
Sbjct: 194  RRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQ 253

Query: 1155 EIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQE 1214
            ++P +R+S VL  +  E+ KLQE  FEL+ SEASY +SLN+ V HF  +  +R  L   E
Sbjct: 254  DLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSE 313

Query: 1215 HQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQ 1274
               LFS + DV  VS  FL +LE   E NI    VCD+V  +A D   VY+ YV+NQTYQ
Sbjct: 314  AHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQ 373

Query: 1275 ERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPG 1334
            ERT++ L+   + FRE++ +LE DP C+ L   SFLILPFQRITRLKLL+QNILKR +  
Sbjct: 374  ERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEER 433

Query: 1335 SSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKS 1394
            S  E  A  AH  LE +++ CN  V+ M RTE++I + +K+EF+ K  P+IS SRWL+K 
Sbjct: 434  SERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQ 493

Query: 1395 GELTALEF-SASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKC 1453
            GEL  +     S  LR K     ++L LFND L++ R   G ++ VFD AP   +R E+ 
Sbjct: 494  GELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEEL 553

Query: 1454 EMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPRE------ELDLL 1507
            E +      N+F L L +N    +A ++ +  +QSE  RW+++LA  R          LL
Sbjct: 554  EDQ-GQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLL 612

Query: 1508 ECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVE 1567
            +C   PQVQC+  Y  ++ DEL LE AD++ +  ++ DGW+ G RL D ERGWFP    E
Sbjct: 613  DC---PQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTE 669

Query: 1568 FISNPEVRAQNLKEAHRV 1585
             I NP++R+QNLKE  RV
Sbjct: 670  EILNPKIRSQNLKECFRV 687


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
            [Homo sapiens]
          Length = 618

 Score =  370 bits (951), Expect = e-102
 Identities = 221/521 (42%), Positives = 303/521 (58%), Gaps = 28/521 (5%)

Query: 1089 LINSSQLLYQEYSDVVLNKEIQS--QQRLESLSETPG-PSSPRQPRKALVSSESY----- 1140
            LI    LLYQEY D    +EI++  QQ  E    T G P+S   P +     E       
Sbjct: 79   LIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASP 138

Query: 1141 -----LQRLSMASSG----SLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLR 1191
                 L ++ + S+     +LWQ++P +R+S VL  +  E+ KLQE  FEL+ SEASY +
Sbjct: 139  PERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYK 198

Query: 1192 SLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCD 1251
            SLN+ V HF  +  +R  L   E   LFS + DV  VS  FL +LE   E NI    VCD
Sbjct: 199  SLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCD 258

Query: 1252 VVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLI 1311
            +V  +A D   VY+ YV+NQTYQERT++ L+   + FRE++ +LE DP C+ L   SFLI
Sbjct: 259  IVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLI 318

Query: 1312 LPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYL 1371
            LPFQRITRLKLL+QNILKR +  S  E  A  AH  LE +++ CN  V+ M RTE++I +
Sbjct: 319  LPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISI 378

Query: 1372 SQKIEFECKIFPLISQSRWLVKSGELTALEF-SASPGLRRKLNTRPVHLHLFNDCLLLSR 1430
             +K+EF+ K  P+IS SRWL+K GEL  +     S  LR K     ++L LFND L++ R
Sbjct: 379  QKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICR 438

Query: 1431 PREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEK 1490
               G ++ VFD AP   +R E+ E +      N+F L L +N    +A ++ +  +QSE 
Sbjct: 439  QIPGDKYQVFDSAPRGLLRVEELEDQ-GQTLANVFILRLLENADDREATYMLKASSQSEM 497

Query: 1491 LRWISALAMPRE------ELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSS 1544
             RW+++LA  R          LL+C   PQVQC+  Y  ++ DEL LE AD++ +  ++ 
Sbjct: 498  KRWMTSLAPNRRTKFVSFTSRLLDC---PQVQCVHPYVAQQPDELTLELADILNILDKTD 554

Query: 1545 DGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRV 1585
            DGW+ G RL D ERGWFP    E I NP++R+QNLKE  RV
Sbjct: 555  DGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 595


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score =  293 bits (751), Expect = 7e-79
 Identities = 196/578 (33%), Positives = 302/578 (52%), Gaps = 41/578 (7%)

Query: 1034 GWSRQGLR----RPSILPEGSSDSRGPAVEKHPG-------PSDTVVFREKKPKEVMGGF 1082
            G  R+ LR    R ++   G    +G A++  P        PS        K K+ +G  
Sbjct: 143  GMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRK 202

Query: 1083 SRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQ 1142
                    +  QL YQE  +  LN   +S   +  L E+  P   ++    +V       
Sbjct: 203  RGHKGSFKDDPQL-YQEIQERGLNTSQESDDDI--LDESSSPEGTQKVDATIVVK----- 254

Query: 1143 RLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQL 1202
              S   +   W ++P V    +L  ++ E++K QE  FE++ SE SY  SL+I V+ F  
Sbjct: 255  --SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQ 312

Query: 1203 STSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRR 1262
            S  LRAT++  EH  LFS + DV   S  F  DLE+  +  +    + D++  HA     
Sbjct: 313  SKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFH 372

Query: 1263 VYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKL 1322
             Y+ Y +N+ YQ+RT Q L++SN+ FRE L ++E  P C  L + SFLILP QR+TRL L
Sbjct: 373  PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 432

Query: 1323 LLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEF-ECKI 1381
            L+  +  +TQ  S     A++A  A+ +L+R CN     M R E++  L  +++F + K 
Sbjct: 433  LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 492

Query: 1382 FPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPV-HLHLFNDCLLLSRPREGSRFLVF 1440
             PLIS SRWL+K GEL  +E     GL RK+ +RP  +L LFND L++++ +    ++V 
Sbjct: 493  LPLISASRWLLKRGELFLVE---ETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQ 549

Query: 1441 DHAPFSSIRGEK---CEMKLHG--------PHKNLFRLFLRQNTQGAQAEFLFRTETQSE 1489
            D+A  + I+ EK    E+ L G        PH   F++ L +N++G Q + L  +++ S+
Sbjct: 550  DYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHP--FQVTLLRNSEGRQEQLLLSSDSASD 607

Query: 1490 KLRWISALA-MPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWL 1548
            + RWI AL    R+   L    + PQV+  +A+  ++ DE+ L++ADVV+V QQ  DGWL
Sbjct: 608  RARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQ-EDGWL 666

Query: 1549 EGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVK 1586
             G RL DGE GWFP     FI++      N++   R++
Sbjct: 667  YGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLR 704


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
            exchange factor [Homo sapiens]
          Length = 871

 Score =  288 bits (736), Expect = 4e-77
 Identities = 240/792 (30%), Positives = 372/792 (46%), Gaps = 100/792 (12%)

Query: 856  PKSRGRSRSTRGGHMNSGGH-AKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSR 914
            PKS    ++  GG   S  + A T PA     V  P    RT   PA     E  T  + 
Sbjct: 111  PKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPP---RTPNAPAPCTPEEDLTGLTA 167

Query: 915  SK--SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKD-EAGVSEHPEAPARE---PL 968
            S   S  + G+A +N           +P +    G  +KD E G+   P+  + E   PL
Sbjct: 168  SPVPSPTANGLAANN----------DSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPL 217

Query: 969  RRTTPQQG-----------ASGPGRSPVGQARQPEKP--SHLHLEKASSW---PHRR--- 1009
            +R   Q+             + P    VG+ +   K   S + + K+++    PH+R   
Sbjct: 218  QRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLK 277

Query: 1010 --DSGRPPGDSSGQAVAPSEGANK--HKGWSRQGLR----RPSILPEGSSDSRGPAVEKH 1061
                    G   G A   SE  N     G  R+GLR    R +++     DS   + +K+
Sbjct: 278  VRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKN 337

Query: 1062 --PGPSDTVVFREKKPKEVMGGFSRRCSKLINS-----SQLLYQEYSDVVLNKEIQSQQR 1114
                P   VV  +K+    +G   ++  K   +     + +LYQ Y +  L  +I S + 
Sbjct: 338  RMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKAL--DIDSDEE 395

Query: 1115 LESLSETPGPSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQK 1174
             E       P   +   K ++  +            S W ++  V+   +  +++ E++K
Sbjct: 396  SE-------PKEQKSDEKIVIHHKPLR---------STWSQLSAVKRKGLSQTVSQEERK 439

Query: 1175 LQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLS 1234
             QE  FE+I SE SYL SL I +  F+ S  L  T++  E   LFS + DV + S  F  
Sbjct: 440  RQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFI 499

Query: 1235 DLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEK 1294
            +LE   +NNIF   + D+V  H       Y+ Y TN+ YQ+RT Q L+ +N +F+EVL +
Sbjct: 500  ELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSR 559

Query: 1295 LESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRD 1354
            +ES   C+ L + SFLILP QR+TRL LL+  I ++T   S +     +A   + +L+R 
Sbjct: 560  IESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRL 619

Query: 1355 CNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNT 1414
            CN   + M RTE +  ++ ++EF+ K FPL+S SRWLVK GELTA     +    R+ + 
Sbjct: 620  CNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAY-VEDTVLFSRRTSK 678

Query: 1415 RPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKC--EMKLHGPHKN--------- 1463
            + V+  LFND L++++ +    + V D++    +  E C  E     P KN         
Sbjct: 679  QQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQ 738

Query: 1464 -----LFRLFLRQNTQGAQAEFLFRTETQSEKLRWISALA-----MPREELDLLECYNSP 1513
                 LF L +  N    + E L   ETQSE+ RWI+AL       P +   L       
Sbjct: 739  SSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSL------T 792

Query: 1514 QVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            QV+ +R++  ++ DEL+L+ ADVV++ Q+ SDGW EG RL DGERGWFP++  + I+   
Sbjct: 793  QVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQA 852

Query: 1574 VRAQNLKEAHRV 1585
               +N++   R+
Sbjct: 853  TIDKNVERMGRL 864


>gi|32307166 Rho guanine exchange factor 15 [Homo sapiens]
          Length = 841

 Score =  270 bits (689), Expect = 1e-71
 Identities = 188/537 (35%), Positives = 283/537 (52%), Gaps = 43/537 (8%)

Query: 1064 PSDTVVFREKKPKEVMGGFSRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPG 1123
            P  TV  RE++  EV+     +  +L    + LYQ Y   VL++E+       S S    
Sbjct: 323  PPATVEGREEEGLEVL---KEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANA 379

Query: 1124 PSSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELI 1183
              +P  PR                   +LWQE+P V+ S +L +++ +++++QE  FE++
Sbjct: 380  GDAPTFPRPP-------------GPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVV 426

Query: 1184 VSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENN 1243
             SEASYLRSL +  D F LS +LR TL+ ++H  LFS +Q V+ VS  FL+ L     ++
Sbjct: 427  TSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSS 486

Query: 1244 IFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQR 1303
                 +CDVV  HA     VY+ YV NQ YQE T+  LM++N  F   L +L+S P C+R
Sbjct: 487  PHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCER 546

Query: 1304 LSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMR 1363
            L L SFL+LPFQRITRL++LLQNIL++T+ GSS +  A KA  A+ ++I  C+  V  M+
Sbjct: 547  LPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMK 606

Query: 1364 RTEELIYLSQKIEF-ECKIFPLISQSRWLVKSGELTALEFSASPGLRR-------KLNTR 1415
            +TEELI L+Q++ F + K  PL+S SR L   GELT L      G RR       +    
Sbjct: 607  QTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTEL------GCRRGGVLFASRPRFT 660

Query: 1416 PVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQG 1475
            P+ L LF+D LL+++P+ G R  V D+A  S ++ ++       P    FRL L  N QG
Sbjct: 661  PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPP---TFRLSLLSNHQG 717

Query: 1476 AQAEFLFRTETQSEKLRWISAL----AMPREELDLLECYNSPQVQCLRAYKPRENDELAL 1531
                 L +  + S+  RW+ A      +P     + E  +  Q  C  +  P + +  +L
Sbjct: 718  RPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSL 777

Query: 1532 EKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTA 1588
            E         ++ +GWL+G+       G FP Q V  ++    R ++L++  R+  A
Sbjct: 778  ESRAAPKHLHKTPEGWLKGL------PGAFPAQLVCEVTGEHERRRHLRQNQRLLEA 828



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 52/218 (23%), Positives = 78/218 (35%), Gaps = 26/218 (11%)

Query: 842  LPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPA 901
            LP   PPT+ PP   + R  SRS R        H  + P        LP ++     P  
Sbjct: 6    LPAATPPTQKPPRIIRPRPPSRS-RAAQSPGPPHNGSSPQ------ELPRNSNDAPTPMC 58

Query: 902  TARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPE 961
            T    E   ++ +  + + P  + +++ +   P SP++  TP    P S+  A     PE
Sbjct: 59   TPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTP---SPVSRRSAS----PE 111

Query: 962  APAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQ 1021
               R P+    P      P     G   Q    S       +    RR +GR  G + G+
Sbjct: 112  PAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSAS-------APGTVRRLAGRFEGGAEGR 164

Query: 1022 AV---APSEGANKHKGWSRQGLRRPSILPEGSSDSRGP 1056
            A    AP  G          G R   +   GS ++  P
Sbjct: 165  AQDADAPEPGLQARA--DVNGEREAPLTGSGSQENGAP 200



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 26/105 (24%), Positives = 38/105 (36%), Gaps = 4/105 (3%)

Query: 512 PRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSP---- 567
           PR  + AP          P + S +PP   P   +  +  +  +  +P S   PSP    
Sbjct: 47  PRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRR 106

Query: 568 CGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHR 612
             + E  P +    P    SP  P     G +    S S PG+ R
Sbjct: 107 SASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVR 151


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score = 88.2 bits (217), Expect = 6e-17
 Identities = 93/399 (23%), Positives = 179/399 (44%), Gaps = 37/399 (9%)

Query: 1120 ETPGPSSPRQPRKALVS-----SESYLQRLSMASSGSLWQEIPVVRNSTVLLSMTHEDQK 1174
            E+PGP       +A+ S     S  YL  L    S   W++    +  T+  S T E +K
Sbjct: 47   ESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKS--CQPVTLSGSGTQEPEK 104

Query: 1175 LQEVKFELIVSEASYLRSLNIAVDHF--QLSTSLRATLSNQEH--QWLFSRLQDVRDV-S 1229
              ++  EL+ +E +Y+  L++    F  +L  + R++ +  E   + +FS +  +    S
Sbjct: 105  --KIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHS 162

Query: 1230 ATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFR 1289
              FL +L+   ++   + ++ DV+   AP F ++Y  YV N         +  + +  F+
Sbjct: 163  QFFLPELQRRLDDWTANPRIGDVIQKLAP-FLKMYSEYVKNFERAAELLATWTDKSPLFQ 221

Query: 1290 EVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALE 1349
            EVL +++S      L+L+  ++ P QRI R +LLL+  +++    + ++A+A KA   + 
Sbjct: 222  EVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIF 281

Query: 1350 QLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPGLR 1409
               +  N  +  M R ++L  + Q++  E  I   +  S  L++ G +  + F  +  + 
Sbjct: 282  SAAQHSNAAITEMERLQDLWEVYQRLGLEDDI---VDPSNTLLREGPVLKISFRRNDPME 338

Query: 1410 RKLNTRPVHLHLFNDCLLLSRPR---EGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNLFR 1466
            R       +L LFN+ LL   PR    G++F V      + ++  +  M    PH  L  
Sbjct: 339  R-------YLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVREL-MDAEFPHSFL-- 388

Query: 1467 LFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELD 1505
                    G Q     +  +Q E + W+ A     ++++
Sbjct: 389  ------VSGKQRTLELQARSQEEMISWMQAFQAAIDQIE 421


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 76/333 (22%), Positives = 155/333 (46%), Gaps = 27/333 (8%)

Query: 1172 DQKLQEVKFELIVSEASYLRSLNIAVDHFQ---LSTSLRATLSNQEHQWLFSRLQDVRDV 1228
            +QKL ++  EL+++E +Y+  L++    F    L  + R +   +    +FS +  +   
Sbjct: 204  EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAF 263

Query: 1229 SATFL-SDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSN 1287
             + FL  +LE+  +    + ++ D++   AP F ++Y  YV          +++      
Sbjct: 264  HSKFLLPELEKRMQEWETTPRIGDILQKLAP-FLKMYGEYVKGFDNAMELVKNMTERIPQ 322

Query: 1288 FREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHA 1347
            F+ V+E+++   +C  L+L+  ++ P QRI R ++LL++ L++  P S +  +A K+   
Sbjct: 323  FKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382

Query: 1348 LEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSASPG 1407
            +       N+ ++ M   ++L+ + + +  E  I   ++ S  L+K G++  L       
Sbjct: 383  ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDI---VNPSNELIKEGQILKL------- 432

Query: 1408 LRRKLNTRPVHLHLFNDCLLLSRPR---EGSRFLVFDHAPFSSIRGEKCEMKLHGPHKNL 1464
              R  + +  +L LFN+ LL   P+    GS+F V        I G K     +  + + 
Sbjct: 433  AARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV---GIDGMKIVETQNEEYPHT 489

Query: 1465 FRLFLRQNTQGAQAEFLFRTETQSEKLRWISAL 1497
            F++  ++ T   QA       +  +K  WI AL
Sbjct: 490  FQVSGKERTLELQA------SSAQDKEEWIKAL 516


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 160/658 (24%), Positives = 217/658 (32%), Gaps = 95/658 (14%)

Query: 385  GRLGAVGRARSREEE----NEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESR 440
            G LG  G   S EE          P   AL A          PG     T  P     SR
Sbjct: 118  GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPG-----TPSPAMARRSR 172

Query: 441  AE--ELSPAALSPSLEPIRCSHQPISLLGSF----LTEESPDKEIDQNSQQEESRLRKGT 494
            A   E+     +PS  P   +  P   + S      TE SP      ++     R    +
Sbjct: 173  AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 232

Query: 495  VSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPE 554
            +SS  T +   + S    R    AP  P++  P      + RPP   P R+ +  A  P 
Sbjct: 233  LSSSATPLSSPARSGPSARGTPRAPAHPSQPKP--KGLQALRPPQVTPPRKDAAPALGP- 289

Query: 555  TASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTE 614
             +S+PL+   PS    S   P +L   PS   +PP     S G      S +   +H   
Sbjct: 290  LSSSPLATPSPS-APPSPSAPPSLQTLPSPPATPPSQATTSLG------SPTLQATHSFL 342

Query: 615  QTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQ 674
             +P L  +      +  PQ PP  A+     P     S       + SP A + L     
Sbjct: 343  PSPPLSPLA-----TPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNAL----- 392

Query: 675  ESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRD 734
             ++  L+ P SPP   P  +P +P  +       + PS            +PP PP    
Sbjct: 393  -AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP 451

Query: 735  THPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKG-PLPQAS-------DPAVAR 786
              PS          +     Q + PPP A  +    P +  P P AS        P+ + 
Sbjct: 452  MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASL 511

Query: 787  QHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIID 846
               PL + P  +    A P  +     P +P L  P  PP   P +S +  P   L +  
Sbjct: 512  PMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTS-VSGPRLTLALAP 570

Query: 847  PPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARST 906
             P  PP   P S   S     GH +S   A + P         P      S PP    + 
Sbjct: 571  GPPPPPSRSPSST-LSGPDLAGHSSS---ATSTPEELRGYDSGPEGGAAASPPPDAELAA 626

Query: 907  ESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPARE 966
                + SR  +   P +AF        P +P  PW P   GP S D        E P   
Sbjct: 627  CHPAAWSRGPA---PPLAFRG-----APGAPL-PWPPAT-GPGSADGLCTIYETEGP--- 673

Query: 967  PLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVA 1024
                 TP  GA  PG S                               PG S G+A A
Sbjct: 674  --ESATPAPGALDPGPS-------------------------------PGTSGGKAAA 698



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 164/673 (24%), Positives = 224/673 (33%), Gaps = 106/673 (15%)

Query: 385  GRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEEL 444
            G  GAVGR    E      G ++P   AP   P     P AS    + P  +  S     
Sbjct: 48   GAAGAVGRKPLAERAGGIGGATIPES-APRAGPTRTSRPPASGRGERAPPAKNTSPGPVS 106

Query: 445  SPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVF 504
            SP   S +  P      P+   G  ++ E                + +G  +        
Sbjct: 107  SPGRASGTTRP-----GPLGQKGLRISAEET--------------VARGKATEAPKRSAL 147

Query: 505  ASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDD 564
            ++ +      P    PSPA A      S +A   V  PR   S   R P T     S+  
Sbjct: 148  SAGARRDTSGPTPGTPSPAMAR----RSRAAGTEVGLPRPAPSARPRPP-TEGPRKSVSS 202

Query: 565  PSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLL 624
             S   T+E  PAA    PS G    RP + S      L S + P S      P   G   
Sbjct: 203  ASEHSTTEPSPAARRR-PSAGGGLQRPASRS------LSSSATPLSSPARSGPSARGTPR 255

Query: 625  SYSHSELPQ-------RPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESI 677
            + +H   P+       RPP+      VTP R + +      +S+SP A          S 
Sbjct: 256  APAHPSQPKPKGLQALRPPQ------VTPPR-KDAAPALGPLSSSPLATP--------SP 300

Query: 678  SNLERPSSPPSIQPWVSPHN--PAFATES---PAYGSSPSFVSMEDVRIHEPLPPPPPQR 732
            S    PS+PPS+Q   SP    P+ AT S   P   ++ SF+    +    PL  PPPQ 
Sbjct: 301  SAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPL---SPLATPPPQA 357

Query: 733  RDTHPSVVETDGHARVVVPTLKQHSHPPPLALGS-GLHAPHKGPLPQASDPAVARQHRPL 791
                         +    P L   + P P A  +  +H       P  S P  A    P 
Sbjct: 358  PPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 417

Query: 792  --PSTPDSSHHAQATPRWRYNK-PLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPP 848
              P +P ++  +QA P        +PP+P    P  P  + P  +      PPL +  PP
Sbjct: 418  SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPP 477

Query: 849  TEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTES 908
             + PP                      A   P  Q    P  +  G+  + P+       
Sbjct: 478  PQAPP----------------------ALATPPLQALPSPPASFPGQAPFSPS------- 508

Query: 909  FTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPL 968
              S   S     P  A   +   L    P+ P +P LQ P      G       P    L
Sbjct: 509  -ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR---L 564

Query: 969  RRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR---RDSGRPPGDSSGQAVAP 1025
                       P RSP      P+     H   A+S P      DSG P G ++      
Sbjct: 565  TLALAPGPPPPPSRSPSSTLSGPDLAG--HSSSATSTPEELRGYDSG-PEGGAAASPPPD 621

Query: 1026 SEGANKH-KGWSR 1037
            +E A  H   WSR
Sbjct: 622  AELAACHPAAWSR 634


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 136/581 (23%), Positives = 241/581 (41%), Gaps = 64/581 (11%)

Query: 959  HPEAPAR---EPLRRT-TPQQGASGPGRSPVGQARQPEKPSHLHLEKASS--WPHRRDSG 1012
            HPE P R   +P   T TP Q  S   R+P  + + P KPS+L + +      P      
Sbjct: 126  HPEGPQRLRSDPGPPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMPRMPPPLEPIPPPPS 185

Query: 1013 RP-PGDSS-GQAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVF 1070
            RP P D    + +AP   A+         + +    P   +  R P     PGP + V+ 
Sbjct: 186  RPLPADPRVAKGLAPRAEASPSSAAVSSLIEKFEREPVIVASDR-PVPGPSPGPPEPVML 244

Query: 1071 REKKPK----EVMGGFSRRCSKLI-----NSSQLLYQEYSDVVLNKEIQSQQRL------ 1115
             +   +    ++  G + RC  L+     +  ++  ++     ++    S++        
Sbjct: 245  PQPTSQPPVPQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDG 304

Query: 1116 -ESLSETPGP----------SSPRQPRKALVSSESYLQRLSMASSGSLWQEIPVV---RN 1161
              S S  PGP          + P +P    V S+   +           +EIPV    R 
Sbjct: 305  PPSHSLCPGPPALASVPVALADPHRPGSQEVDSDLE-EEDDEEEEEEKDREIPVPLMERQ 363

Query: 1162 STVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQL----STSLRATLSNQEHQW 1217
             +V L++    QK+  +  EL+ +E +Y+  L++    F          R++        
Sbjct: 364  ESVELTV---QQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHG 420

Query: 1218 LFSRLQDVRDVSATFL-SDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQER 1276
            +FS +  +      FL  +LE+  E      ++ D++   AP F ++Y  YV N      
Sbjct: 421  IFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAP-FLKMYGEYVKNFDRAVE 479

Query: 1277 TFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSS 1336
               +    ++ F+ ++ +++ +  C  L+L+  ++ P QRI R +LLL++ L +   GS 
Sbjct: 480  LVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSP 539

Query: 1337 EEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGE 1396
            +  +A K+   +       N  ++ M R  +L+ + + +  E  I   +S ++ L+K G 
Sbjct: 540  DSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDI---VSPTKELIKEGH 596

Query: 1397 LTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEKCEMK 1456
            +  L+ SA  G      T+  +L LFND LL   PR   R L    +  + I  +  E+K
Sbjct: 597  I--LKLSAKNG-----TTQDRYLILFNDRLLYCVPR--LRLLGQKFSVRARIDVDGMELK 647

Query: 1457 LHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWISAL 1497
                + NL R FL     G Q     +  T+ EK  W+ A+
Sbjct: 648  -ESSNLNLPRTFL---VSGKQRSLELQARTEEEKKDWVQAI 684



 Score = 34.3 bits (77), Expect = 0.99
 Identities = 37/140 (26%), Positives = 55/140 (39%), Gaps = 22/140 (15%)

Query: 683 PSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIH-EPLPPPPPQRRDTHPSVVE 741
           P+  PS +P      P      P     PS++ M  +    EP+PPPP +     P V  
Sbjct: 140 PTETPSQRPSPLKRAPG---PKPQVPPKPSYLQMPRMPPPLEPIPPPPSRPLPADPRV-- 194

Query: 742 TDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHA 801
               A+ + P  +  + P   A+ S +    + P+  ASD  V     P P  P+     
Sbjct: 195 ----AKGLAP--RAEASPSSAAVSSLIEKFEREPVIVASDRPVP---GPSPGPPEPVMLP 245

Query: 802 QATPRWRYNKPLPPTPDLPQ 821
           Q T +       PP P LP+
Sbjct: 246 QPTSQ-------PPVPQLPE 258



 Score = 32.0 bits (71), Expect = 4.9
 Identities = 29/95 (30%), Positives = 35/95 (36%), Gaps = 23/95 (24%)

Query: 765 GSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKP-LPPTPD-LPQP 822
           G  L    +GP    SDP         P T   S       R    KP +PP P  L  P
Sbjct: 120 GQSLEPHPEGPQRLRSDPG--------PPTETPSQRPSPLKRAPGPKPQVPPKPSYLQMP 171

Query: 823 HLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPK 857
            +PP           PL P+P   PP+ P P  P+
Sbjct: 172 RMPP-----------PLEPIP--PPPSRPLPADPR 193


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 165/671 (24%), Positives = 235/671 (35%), Gaps = 96/671 (14%)

Query: 385 GRLGAVGRARSREEE----NEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESR 440
           G LG  G   S EE          P   AL A          PG     T  P     SR
Sbjct: 127 GPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPG-----TPSPAMARRSR 181

Query: 441 AE--ELSPAALSPSLEPIRCSHQPISLLGSF----LTEESPDKEIDQNSQQEESRLRKGT 494
           A   E+     +PS  P   +  P   + S      TE SP      ++     R    +
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRS 241

Query: 495 VSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPE 554
           +SS  T +   + S    R    AP  P++  P      + RPP   P R+ +  A  P 
Sbjct: 242 LSSSATPLSSPARSGPSARGTPRAPAHPSQPKP--KGLQALRPPQVTPPRKDAAPALGP- 298

Query: 555 TASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTE 614
            +S+PL+   PS      + P      P   T PP PP  +T       S S P S +T 
Sbjct: 299 LSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPL-ATPLPLAPPSPSAPPSLQTL 357

Query: 615 QTPDLV------------GMLLSYSHSELP-------------QRPPKPAIYSSVTPRRD 649
            +P                M    S   +P             Q PP P   SS+     
Sbjct: 358 PSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTS 417

Query: 650 RRSGRDYSTVSASPTALSTLKQDSQESISNLERPS-----SPPSIQPWVSPHNPAFATE- 703
             S     T+ A+ + L+   + +Q S+++  RP+     SPP   P   P +P   T  
Sbjct: 418 LGS----PTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSL 473

Query: 704 SPAYG--SSPSFV----SMEDVRIHEP-------LPPPPPQRRDTHPSVVETDGHARVVV 750
           SPA    SSP  +    ++  +  H P       + PP   +    P  ++T   A +  
Sbjct: 474 SPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTP-PASLTT 532

Query: 751 PTLKQ--HSHPPPLALGSG-LHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRW 807
           P L+      PPPL   S  L  PH    P  +   +     PL + P  +  + ATP  
Sbjct: 533 PPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPP 592

Query: 808 RYNKPL--PPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRST 865
           +    L  PP   LP P L P++ P       P   LP +  P  PP  PP S   + S 
Sbjct: 593 QAPPALASPPLQGLPSPPLSPLATPPPQA--PPXLALPPLQAPPSPPASPPLSPLATPSP 650

Query: 866 RGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAF 925
           +  +     H    P     + P+ A     + PP +  +T          S+  P +A 
Sbjct: 651 QAPNA-LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSAT--------PPSQAPPSLAA 701

Query: 926 SNMTNFLCPSSPTTP-----WTPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGP 980
             +   + PS P +P      TP  Q P       +   P  PA  P+        A+ P
Sbjct: 702 PPLQ--VPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPM-----SPSATPP 754

Query: 981 GRSPVGQARQP 991
            R P   A  P
Sbjct: 755 PRVPPLLAAPP 765



 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 176/709 (24%), Positives = 257/709 (36%), Gaps = 123/709 (17%)

Query: 405  PSMPALIAPED-SPHCDLFPGASYLMTQIPGTQTESRAEELS--PAALSPSLEPIRCSHQ 461
            P  P L  P   +P     P +   +   P T        ++  P    PSL+ I     
Sbjct: 332  PPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQV 391

Query: 462  PISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFA----SASVTPPRTPDS 517
            P SL    L  ++P   +  +S Q  + L   T+ +  + +  +     AS+T P  P S
Sbjct: 392  PHSLTSPSL--QAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS 449

Query: 518  APP-SPAEAYPIT-----PASVSARP---PVAFP------RRETSCAARAPETASAPLSM 562
             PP SP    P++     P   S  P   P++ P      +  +S A+ +P+   APLS 
Sbjct: 450  TPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQ---APLSS 506

Query: 563  DDPSPCGT-SEMCPAALYGFPSTGTSPP-------RPPANSTG----TVQHLRSDSFPGS 610
                P  T S + P +L   P++ T+PP        PP   T     T  HL +   P  
Sbjct: 507  LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP 566

Query: 611  HRTEQTPDLVGMLLSYSHSELPQRPPK--PAIYSSVTPRRDRRSGRDYSTVSASPTALST 668
               +  P  +      + S +   PP+  PA+ S           +   +   SP A   
Sbjct: 567  CPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPL--------QGLPSPPLSPLATPP 618

Query: 669  LKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPP 728
             +     ++  L+ P SPP+  P +SP     AT SP    +P+ +++  ++     PP 
Sbjct: 619  PQAPPXLALPPLQAPPSPPASPP-LSP----LATPSP---QAPNALAVHLLQAPFSPPPS 670

Query: 729  PPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPL-----------P 777
            PP +    P        +  V P+    S  PP      L  P   P            P
Sbjct: 671  PPVQAPFSPPA------SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 724

Query: 778  QASDPAVARQHRPLPSTPDSSHHA-QATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIY 836
            QA  P  A   +  PS P S   +  ATP  R   PL   P L  P  PP S P  S + 
Sbjct: 725  QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV-PPLLAAPPLQVPPSPPASLP-MSPLA 782

Query: 837  RPLPPLP--IIDPPTEPPPLPPKS-RGRSRSTRGGHMNSGGHAKTRP------ACQDWTV 887
            +P P  P  +  PP +  P PP S  G++  +    +     A   P      A     V
Sbjct: 783  KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 842

Query: 888  PLPASAGRTSWPPATARSTESFTSTSRSKSEVS------PGMAFSNMTNFLCP-----SS 936
            P    A  T   P    +    TS S  +  ++      P  + S  +    P     SS
Sbjct: 843  PPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSS 902

Query: 937  PTTPWTPELQGPTSKDEAGVSE-----------HPEAPAREPLRRTT---------PQQG 976
              T    EL+G  S  E G +            HP A +R P              P   
Sbjct: 903  SATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 962

Query: 977  ASGPGRSP-VGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVA 1024
            A+GPG +  +    + E P     E A+  P   D G  PG S G+A A
Sbjct: 963  ATGPGSADGLCTIYETEGP-----ESATPAPGALDPGPSPGTSGGKAAA 1006



 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 149/633 (23%), Positives = 213/633 (33%), Gaps = 114/633 (18%)

Query: 396 REEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALSPSLEP 455
           R+ +     PS PA   P DSP       A   +   P  QT S +  +SP +   ++ P
Sbjct: 435 RQTQASLTSPSRPAS-TPPDSPPLQ----APLSLPASPPLQT-SLSPAVSPLSSPLTIHP 488

Query: 456 IRC-----SHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTE--------- 501
           ++      SH P + L S +    P  E   +      +    ++++   E         
Sbjct: 489 LQALSSLASHSPQAPLSSLIM---PPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPP 545

Query: 502 VVFASASVTPPRT---------PDSAPPSPAEAYPI-TPASVSARPPVAFPRRETSCAAR 551
           +  ASA +T P           P  APPSP    P  TP+S++  PP A P   +     
Sbjct: 546 LQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQG 605

Query: 552 APETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSH 611
            P    +PL+   P P     +    L   PS   SPP  P  +                
Sbjct: 606 LPSPPLSPLAT--PPPQAPPXLALPPLQAPPSPPASPPLSPLATP--------------- 648

Query: 612 RTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQ 671
            + Q P+ + + L  +    P  PP  A +S              ++   SP+A    + 
Sbjct: 649 -SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP------------ASPPVSPSATPPSQA 695

Query: 672 DSQESISNLERPSSPPSIQPW--------------------VSPHNPAFATESPAYGSSP 711
               +   L+ P SPP+  P                     V P  PA    SP+    P
Sbjct: 696 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPP 755

Query: 712 SFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAP 771
                   R+   L  PP Q   + P+ +     A+         + PP  AL S    P
Sbjct: 756 --------RVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPS---PP 804

Query: 772 HKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPG 831
              P      P+ +    PL + P  +    A P  +     P +P L  P  PP   P 
Sbjct: 805 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 864

Query: 832 SSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPA 891
           +S +  P   L +   P  PP   P S   S     GH +S   A + P         P 
Sbjct: 865 TS-VSGPRLTLALAPGPPPPPSRSPSST-LSGPDLAGHSSS---ATSTPEELRGYDSGPE 919

Query: 892 SAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSK 951
                S PP    +     + SR     +P +AF        P +P  PW P   GP S 
Sbjct: 920 GGAAASPPPDAELAACHPAAWSRGP---APPLAFRG-----APGAP-LPW-PPATGPGSA 969

Query: 952 DEAGVSEHPEAPAREPLRRTTPQQGASGPGRSP 984
           D        E P        TP  GA  PG SP
Sbjct: 970 DGLCTIYETEGP-----ESATPAPGALDPGPSP 997



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 122/495 (24%), Positives = 182/495 (36%), Gaps = 99/495 (20%)

Query: 487 ESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRET 546
           ES  R G   S GT            R P S PP+        PA  ++  PV+ P R +
Sbjct: 72  ESAPRAGPTRSAGTS----------SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRAS 121

Query: 547 SCAARAP-ETASAPLSMDDPSPCGTSEMCP--AALYGFPSTGTSPPRPPANSTGTVQHLR 603
                 P       +S ++    G +   P  +AL       TS P P   S    +  R
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 604 SDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASP 663
           +        TE     VG+         P   P+P    +  PR+   S  ++ST   SP
Sbjct: 182 AAG------TE-----VGL-----PRPAPSARPRP---PTEGPRKSVSSASEHSTTEPSP 222

Query: 664 TAL------STLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSME 717
            A         L++ +  S+S+   P S P+     +   P     +PA+ S P    ++
Sbjct: 223 AARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTP----RAPAHPSQPKPKGLQ 278

Query: 718 DVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLP 777
            +R  +  PP    R+D  P                         ALG    +P   P P
Sbjct: 279 ALRPPQVTPP----RKDAAP-------------------------ALGPLSSSPLATPSP 309

Query: 778 QASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDL--PQPHLPPISAPGSSRI 835
             +      + RP+P  PD++    ATP       LPP+P L  P P  PP  +P +   
Sbjct: 310 SGT------KARPVP-PPDNA----ATP---LPATLPPSPPLATPLPLAPP--SPSAPPS 353

Query: 836 YRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASA-- 893
            + LP  P   P   PP +         S +        H+ T P+ Q    PL  S+  
Sbjct: 354 LQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQ 413

Query: 894 GRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDE 953
             TS    T ++T SF +       +SP    +++T+   P+S T P +P LQ P S   
Sbjct: 414 ATTSLGSPTLQATHSFLT-------MSPRQTQASLTSPSRPAS-TPPDSPPLQAPLSLPA 465

Query: 954 AGVSEHPEAPAREPL 968
           +   +   +PA  PL
Sbjct: 466 SPPLQTSLSPAVSPL 480


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 68/267 (25%), Positives = 119/267 (44%), Gaps = 20/267 (7%)

Query: 1172 DQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSAT 1231
            ++K Q    ELI +E  Y+  L + V+ FQ   +    L+  E   +F   +++   +  
Sbjct: 1180 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1239

Query: 1232 FLSDLE--ENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFR 1289
             L  L   +         Q+   +L       + Y+ + + Q       Q   + +++F+
Sbjct: 1240 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1299

Query: 1290 EVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALE 1349
            E L+KL SDP C+ + L SFL+ P QRITR  LL+++IL+ T    ++ +    A    E
Sbjct: 1300 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1359

Query: 1350 QLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQS-------RWLVKSGELTALEF 1402
            +L    N  V+    ++ L ++   ++ E     LI  S       R L+ SG+      
Sbjct: 1360 ELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK------ 1413

Query: 1403 SASPGLRRKLNTRPVHLHLFNDCLLLS 1429
                 L +  + + +H  LFND LLL+
Sbjct: 1414 -----LYKTKSNKELHGFLFNDFLLLT 1435



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 19/64 (29%), Positives = 33/64 (51%), Gaps = 3/64 (4%)

Query: 1514 QVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            + Q L ++  ++++ L   K D++ V +Q  + W   V    G RGWFP   V+ I   E
Sbjct: 875  KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVH---GGRGWFPKSYVKIIPGSE 931

Query: 1574 VRAQ 1577
            V+ +
Sbjct: 932  VKRE 935



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 16/64 (25%), Positives = 34/64 (53%), Gaps = 3/64 (4%)

Query: 1516 QCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDG---ERGWFPVQQVEFISNP 1572
            Q   AY    +++L+L    ++++ ++++ GW +G   + G   ++GWFP   V+ +   
Sbjct: 1032 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS 1091

Query: 1573 EVRA 1576
              RA
Sbjct: 1092 SERA 1095



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 9/110 (8%)

Query: 1466 RLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELDLLECYNSPQVQCLRAYKPRE 1525
            RL   +  +  Q E     E Q +    + A    RE   +L  Y +     L  ++ R 
Sbjct: 691  RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRA-----LYPFEARN 745

Query: 1526 NDELALEKADVVMVTQQS--SDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            +DE++    D++ V +++    GWL G     G  GWFP   VE + + E
Sbjct: 746  HDEMSFNSGDIIQVDEKTVGEPGWLYG--SFQGNFGWFPCNYVEKMPSSE 793


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 68/267 (25%), Positives = 119/267 (44%), Gaps = 20/267 (7%)

Query: 1172 DQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRDVSAT 1231
            ++K Q    ELI +E  Y+  L + V+ FQ   +    L+  E   +F   +++   +  
Sbjct: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266

Query: 1232 FLSDLE--ENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFR 1289
             L  L   +         Q+   +L       + Y+ + + Q       Q   + +++F+
Sbjct: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326

Query: 1290 EVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALE 1349
            E L+KL SDP C+ + L SFL+ P QRITR  LL+++IL+ T    ++ +    A    E
Sbjct: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386

Query: 1350 QLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQS-------RWLVKSGELTALEF 1402
            +L    N  V+    ++ L ++   ++ E     LI  S       R L+ SG+      
Sbjct: 1387 ELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK------ 1440

Query: 1403 SASPGLRRKLNTRPVHLHLFNDCLLLS 1429
                 L +  + + +H  LFND LLL+
Sbjct: 1441 -----LYKTKSNKELHGFLFNDFLLLT 1462



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 19/64 (29%), Positives = 33/64 (51%), Gaps = 3/64 (4%)

Query: 1514 QVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            + Q L ++  ++++ L   K D++ V +Q  + W   V    G RGWFP   V+ I   E
Sbjct: 902  KAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVH---GGRGWFPKSYVKIIPGSE 958

Query: 1574 VRAQ 1577
            V+ +
Sbjct: 959  VKRE 962



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 16/64 (25%), Positives = 34/64 (53%), Gaps = 3/64 (4%)

Query: 1516 QCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDG---ERGWFPVQQVEFISNP 1572
            Q   AY    +++L+L    ++++ ++++ GW +G   + G   ++GWFP   V+ +   
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPS 1118

Query: 1573 EVRA 1576
              RA
Sbjct: 1119 SERA 1122



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 29/110 (26%), Positives = 47/110 (42%), Gaps = 9/110 (8%)

Query: 1466 RLFLRQNTQGAQAEFLFRTETQSEKLRWISALAMPREELDLLECYNSPQVQCLRAYKPRE 1525
            RL   +  +  Q E     E Q +    + A    RE   +L  Y +     L  ++ R 
Sbjct: 718  RLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRA-----LYPFEARN 772

Query: 1526 NDELALEKADVVMVTQQS--SDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            +DE++    D++ V +++    GWL G     G  GWFP   VE + + E
Sbjct: 773  HDEMSFNSGDIIQVDEKTVGEPGWLYG--SFQGNFGWFPCNYVEKMPSSE 820


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 81.3 bits (199), Expect = 7e-15
 Identities = 147/619 (23%), Positives = 205/619 (33%), Gaps = 106/619 (17%)

Query: 433  PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRK 492
            P   TE   + +S A+   + EP   + +  S  G    +    + +  ++    S  R 
Sbjct: 198  PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGL--QRPASRSLSSSATPLSSPARS 255

Query: 493  GTVSSQGTEVVFASASVTPP------RTPDSAPPSPAEAYPITPASVSARPPVAFPRRET 546
            G  S++GT    A  S   P      R P   PP    A  + P S S   P+A P    
Sbjct: 256  GP-SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS---PLATPSPSA 311

Query: 547  SCAARAPETASA-------------PLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPA 593
            +  ++AP T  A             PL +  PSP       P +L   PS   +PP    
Sbjct: 312  ALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSA-----PPSLQTLPSPPATPPSQAT 366

Query: 594  NSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSG 653
             S G      S +   +H    +P L  +      +  PQ PP  A+     P     S 
Sbjct: 367  TSLG------SPTLQATHSFLPSPPLSPLA-----TPPPQAPPALALPPLQAPPSPPASP 415

Query: 654  RDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSF 713
                  + SP A + L      ++  L+ P SPP   P  +P +P  +       + PS 
Sbjct: 416  PLSPLATPSPQAPNAL------AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 469

Query: 714  VSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHK 773
                       +PP PP      PS          +     Q + PPP A  +    P +
Sbjct: 470  APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ 529

Query: 774  G-PLPQAS-------DPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLP 825
              P P AS        P+ +    PL + P  +    A P  +     P +P L  P  P
Sbjct: 530  ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP 589

Query: 826  PISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDW 885
            P   P +S +  P   L +   P  PP   P S   S     GH +S   A + P     
Sbjct: 590  PTPGPDTS-VSGPRLTLALAPGPPPPPSRSPSST-LSGPDLAGHSSS---ATSTPEELRG 644

Query: 886  TVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPEL 945
                P      S PP    +     + SR  +   P +AF        P +P  PW P  
Sbjct: 645  YDSGPEGGAAASPPPDAELAACHPAAWSRGPA---PPLAFRG-----APGAPL-PWPPAT 695

Query: 946  QGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSW 1005
             GP S D        E P        TP  GA  PG S                      
Sbjct: 696  -GPGSADGLCTIYETEGP-----ESATPAPGALDPGPS---------------------- 727

Query: 1006 PHRRDSGRPPGDSSGQAVA 1024
                     PG S G+A A
Sbjct: 728  ---------PGTSGGKAAA 737



 Score = 71.6 bits (174), Expect = 6e-12
 Identities = 166/694 (23%), Positives = 224/694 (32%), Gaps = 109/694 (15%)

Query: 385  GRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEEL 444
            G  GAVGR    E      G ++P   AP   P            T+  GT + + A   
Sbjct: 48   GAAGAVGRKPLAERAGGIGGATIPES-APRAGP------------TRSAGTSSRNPASRP 94

Query: 445  SPAALSPSLEPIR-CSHQPISLLG--SFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTE 501
              +       P +  S  P+S  G  S  T   P  +       EE+  R      + TE
Sbjct: 95   PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVAR-----GKATE 149

Query: 502  VVFASASVTPPRTPDSAP----PSPAEA-----------YPITPASVSARPPVAFPRRET 546
                SA     R   S P    PSPA A            P    S   RPP   PR+  
Sbjct: 150  APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSV 209

Query: 547  SCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPR---PPANSTGTVQHLR 603
            S A+    T  +P +   PS  G  +   +      +T  S P    P A  T       
Sbjct: 210  SSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHP 269

Query: 604  SDSFPGSHRTEQTP-------DLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDY 656
            S   P   +  + P       D    L   S S L    P  A+ S   P          
Sbjct: 270  SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP---------- 319

Query: 657  STVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHN--PAFATES---PAYGSSP 711
             T+ A+P + S   Q +         PS+PPS+Q   SP    P+ AT S   P   ++ 
Sbjct: 320  -TLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATH 378

Query: 712  SFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGS-GLHA 770
            SF+    +    PL  PPPQ              +    P L   + P P A  +  +H 
Sbjct: 379  SFLPSPPL---SPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHL 435

Query: 771  PHKGPLPQASDPAVARQHRPL--PSTPDSSHHAQATPRWRYNK-PLPPTPDLPQPHLPPI 827
                  P  S P  A    P   P +P ++  +QA P        +PP+P    P  P  
Sbjct: 436  LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 495

Query: 828  SAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTV 887
            + P  +      PPL +  PP + PP                      A   P  Q    
Sbjct: 496  TPPPQAPPPLAAPPLQLAKPPPQAPP----------------------ALATPPLQALPS 533

Query: 888  PLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQG 947
            P  +  G+  + P+         S   S     P  A   +   L    P+ P +P LQ 
Sbjct: 534  PPASFPGQAPFSPS--------ASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 585

Query: 948  PTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPH 1007
            P      G       P    L           P RSP      P+     H   A+S P 
Sbjct: 586  PRRPPTPGPDTSVSGPR---LTLALAPGPPPPPSRSPSSTLSGPDLAG--HSSSATSTPE 640

Query: 1008 R---RDSGRPPGDSSGQAVAPSEGANKH-KGWSR 1037
                 DSG P G ++      +E A  H   WSR
Sbjct: 641  ELRGYDSG-PEGGAAASPPPDAELAACHPAAWSR 673


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 78/358 (21%), Positives = 157/358 (43%), Gaps = 31/358 (8%)

Query: 1164 VLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQ 1223
            V+  +T  +   QEV  EL V+EAS+LR+L +    F         +  +E   LF  L 
Sbjct: 764  VVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLP 823

Query: 1224 DVRDVSATFLSDLEENFENNIFSFQVCDVVLNH-----APDFRRVYLPYVTNQTYQERTF 1278
            ++ ++  ++   +++  E      ++ D++L         + ++V   + + Q+      
Sbjct: 824  ELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELI 883

Query: 1279 QSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEE 1338
            ++     S F+  +++ ES P C+RL L+  +I   QR+T+  LLL++I+K T+ G+SE 
Sbjct: 884  KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 943

Query: 1339 AEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIE---FECKIFPLISQSRWLVKSG 1395
             +  +A     ++++  N  V+       L    ++++    E    PL ++     KS 
Sbjct: 944  EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAE----FKSL 999

Query: 1396 ELTALEFSASPGLRRKLN---TRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEK 1452
            +LT  +      L  +++   T  +H+ L  D L+L + ++  + L+  H+   +  G  
Sbjct: 1000 DLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ-KQDEKLLLKCHS--KTAVGSS 1056

Query: 1453 CEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTE-------------TQSEKLRWISAL 1497
               +   P   L  + +R      +A F+  T              T S+K  W+  L
Sbjct: 1057 DSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELL 1114


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 78/358 (21%), Positives = 157/358 (43%), Gaps = 31/358 (8%)

Query: 1164 VLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQ 1223
            V+  +T  +   QEV  EL V+EAS+LR+L +    F         +  +E   LF  L 
Sbjct: 724  VVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLP 783

Query: 1224 DVRDVSATFLSDLEENFENNIFSFQVCDVVLNH-----APDFRRVYLPYVTNQTYQERTF 1278
            ++ ++  ++   +++  E      ++ D++L         + ++V   + + Q+      
Sbjct: 784  ELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELI 843

Query: 1279 QSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEE 1338
            ++     S F+  +++ ES P C+RL L+  +I   QR+T+  LLL++I+K T+ G+SE 
Sbjct: 844  KTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEH 903

Query: 1339 AEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIE---FECKIFPLISQSRWLVKSG 1395
             +  +A     ++++  N  V+       L    ++++    E    PL ++     KS 
Sbjct: 904  EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAE----FKSL 959

Query: 1396 ELTALEFSASPGLRRKLN---TRPVHLHLFNDCLLLSRPREGSRFLVFDHAPFSSIRGEK 1452
            +LT  +      L  +++   T  +H+ L  D L+L + ++  + L+  H+   +  G  
Sbjct: 960  DLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQ-KQDEKLLLKCHS--KTAVGSS 1016

Query: 1453 CEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTE-------------TQSEKLRWISAL 1497
               +   P   L  + +R      +A F+  T              T S+K  W+  L
Sbjct: 1017 DSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELL 1074


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 238/1107 (21%), Positives = 387/1107 (34%), Gaps = 215/1107 (19%)

Query: 3    AEEAQRGASPPISAIEEFSIIPEAPMRSSQVSA--LGLEAQEDED----PSYKWREEHRL 56
            A E      PP++ +E+   I    +    V    LG   Q   +    P+ + RE+H +
Sbjct: 620  AHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQH-V 678

Query: 57   SATQQSE--LRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPEHWEAVPQSLAGR 114
              T+ SE    D  D  ++    F +    +   + E    +A       E  P   + +
Sbjct: 679  GGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQAFMLTPPQELGPSHCSFQ 738

Query: 115  QARTLAPP-ELWA----CPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEE 169
               TL  P E+ A    C  +SE  +  PF + L +      + P L+      G    E
Sbjct: 739  TTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEA------YGPCLSPPRAIPGDQHPE 792

Query: 170  EETSSDNSG-QTRYYSPCEEH---PAETNQNEGSESGTI-RQGEELPPE----------- 213
                ++  G Q R     ++    P ET +  G E G + R+ E+L PE           
Sbjct: 793  SPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEEL 852

Query: 214  -----ELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDE 268
                 + ++ Q L    + Q  ++ G+  +  R   +L+ ++     + E+Q+ +Q    
Sbjct: 853  TKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPS 912

Query: 269  KGEQKQKQ--------------EQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKA 314
            K  +++ +              E+V  V+L R  +R    GEPEG   G  +Q+      
Sbjct: 913  KAFEREVERPVANRECDPAELEEKVPKVILERDTQR----GEPEG---GSQDQKGQASSP 965

Query: 315  QGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQ 374
              + G   G+     L  P      S  +      G+   V+ ++   G+          
Sbjct: 966  TPEPGVGAGD-----LPGPTSAPVPSGSQSG----GRGSPVSPRRHQKGLLN-------- 1008

Query: 375  EAKEPESWDGGRLGAVGRARSREEENEHH--GPSMPALIAPEDSPHCDLFPGASYLMTQI 432
              K P +    R+ A  +    ++E+      P++P   AP   P               
Sbjct: 1009 -CKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKP--------------- 1052

Query: 433  PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESP-DKEIDQNSQQEESRLR 491
                ++S+     P  LSP L  I+ + +     GS    E+P   E++    + + R R
Sbjct: 1053 --LNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTR 1110

Query: 492  KGTVSSQGTEVVFASASVTPPRTPDSAP---PSPAEAYPITPASVSARPPVAFPRRETSC 548
            K             S+ +TP     +AP   PS + A P+TP             + TS 
Sbjct: 1111 K-------------SSRMTPFPATSAAPEPHPSTSTAQPVTP-------------KPTSQ 1144

Query: 549  AARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFP 608
            A R+    S   S+  P P     + P A    PST T  P     S  T Q  R     
Sbjct: 1145 ATRSRTNRS---SVKTPEP-----VVPTAPELQPSTSTDQP---VTSEPTSQVTRGRKSR 1193

Query: 609  GSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALST 668
             S +T +T  +V   L    S    RP                       V++ PT+ +T
Sbjct: 1194 SSVKTPET--VVPTALELQPSTSTDRP-----------------------VTSEPTSQAT 1228

Query: 669  LKQDSQESISNLERPSSP--PSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLP 726
              + ++ S+   E P  P  P +QP  S   P   T  P Y ++    +   V+  EP+ 
Sbjct: 1229 RGRKNRSSVKTPE-PVVPTAPELQPSTSTDQPV--TSEPTYQATRGRKNRSSVKTPEPVV 1285

Query: 727  PPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVAR 786
            P  P+ R +      TD   R V P     +      + S +  P    +P A +  ++ 
Sbjct: 1286 PTAPELRPS----TSTD---RPVTPKPTSRTTRSRTNMSS-VKTPET-VVPTAPELQIST 1336

Query: 787  Q-HRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPII 845
               +P+   P S      T R R N      P+   P  P             LPP    
Sbjct: 1337 STDQPVTPKPTSR-----TTRSRTNMSSVKNPESTVPIAPE------------LPPSTST 1379

Query: 846  DPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARS 905
            + P  P P    +RGR   + G    +     T P  +  T     S  +   P  T+++
Sbjct: 1380 EQPVTPEPTSRATRGRKNRSSGKTPET--LVPTAPKLEPST-----STDQPVTPEPTSQA 1432

Query: 906  TESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAR 965
            T   T+ S  K   +P             +S   P TPE   PTS+   G ++       
Sbjct: 1433 TRGRTNRSSVK---TPETVVPTAPELQPSTSTDQPVTPE---PTSQATRGRTDRSSVKTP 1486

Query: 966  EPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRP---PGDSSGQA 1022
            E +  T P+  AS     PV                +   P       P   P  S+ Q 
Sbjct: 1487 ETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQP 1546

Query: 1023 VAPSEGANKHKG-WSRQGLRRP-SILP 1047
            V P   +   +G  +R  ++ P SI+P
Sbjct: 1547 VTPEPTSRATRGRTNRSSVKTPESIVP 1573


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 60/265 (22%), Positives = 119/265 (44%), Gaps = 6/265 (2%)

Query: 1168 MTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQDVRD 1227
            +T  ++K Q    ELIV+E +Y+  L +  + FQ        L+ +E   +F   +++  
Sbjct: 1231 LTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIM 1290

Query: 1228 VSATFLSDLE--ENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSN 1285
             +   L  L   +         ++   +L+      + Y+ + + Q       Q   +  
Sbjct: 1291 CNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEA 1350

Query: 1286 SNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAH 1345
             +F+E +++L  DP C+ + L SF++ P QR+TR  L+++NIL+ T     + +    A 
Sbjct: 1351 PDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHAL 1410

Query: 1346 HALEQLIRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTALEFSAS 1405
               E+L    N  V+    ++ L ++   ++ E     L+  S     +  L   +F  S
Sbjct: 1411 EKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS----VTNCLGPRKFLHS 1466

Query: 1406 PGLRRKLNTRPVHLHLFNDCLLLSR 1430
              L +  + + ++  LFND LLL++
Sbjct: 1467 GKLYKAKSNKELYGFLFNDFLLLTQ 1491



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 3/84 (3%)

Query: 1514 QVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPVQQVEFISNPE 1573
            Q Q L  ++ ++++ L   K DV+ V +Q    W   V+   G++GWFP   V+ IS P 
Sbjct: 917  QAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQ---GQKGWFPKSYVKLISGPI 973

Query: 1574 VRAQNLKEAHRVKTAKLQLVEQQA 1597
             ++ ++        A L+ V   A
Sbjct: 974  RKSTSMDSGSSESPASLKRVASPA 997



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 23/68 (33%), Positives = 33/68 (48%), Gaps = 9/68 (13%)

Query: 1516 QCLRAYKPRENDELALEKADVVMV-------TQQSSDGWLEGVRLSDGERGWFPVQQVEF 1568
            + L  ++ R +DE+ ++  D+VMV       +Q    GWL G     G+ GWFP    E 
Sbjct: 746  RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGE--LKGKTGWFPANYAEK 803

Query: 1569 ISNPEVRA 1576
            I   EV A
Sbjct: 804  IPENEVPA 811



 Score = 34.3 bits (77), Expect = 0.99
 Identities = 36/169 (21%), Positives = 75/169 (44%), Gaps = 12/169 (7%)

Query: 187 EEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTL 246
           +E  A+  + E       RQ +E    +L+  + L   +E++   E+ +++   R E   
Sbjct: 380 QERLAQLERAEQERKERERQEQERK-RQLELEKQLEKQRELERQREEERRKEIERREAAK 438

Query: 247 REDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWE 306
           RE       L  ++ +E   + + E   ++ + Q+ ++  + ++  L  E E LND + +
Sbjct: 439 RE-------LERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQ 491

Query: 307 QE----DMERKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGK 351
            E    D+  +   Q    +   + REL++ E      Q ++SQ  LG+
Sbjct: 492 LEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGR 540


>gi|21735572 epithelial cell transforming sequence 2 oncogene protein
            [Homo sapiens]
          Length = 883

 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 67/262 (25%), Positives = 118/262 (45%), Gaps = 15/262 (5%)

Query: 1177 EVKFELIVSEASYLRSLNIAVDHFQLSTSLRAT-----LSNQEHQWLFSRLQDVRDVSAT 1231
            +V  EL  +E++Y+  L   +  FQ+            L+ +E + +F  + D+ DV   
Sbjct: 424  QVAKELYQTESNYVNILATIIQLFQVPLEEEGQRGGPILAPEEIKTIFGSIPDIFDVHTK 483

Query: 1232 FLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLMNSNSNFREV 1291
               DLE+   N   S  + D+ L ++ D  + Y P+V      + T          F   
Sbjct: 484  IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYPPFVNFFEMSKETIIKCEKQKPRFHAF 543

Query: 1292 LEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEEAEATKAHHALEQL 1351
            L+  ++ P C R SL   LI P QR+  + LLL ++ K T   + +++   KA  +L+++
Sbjct: 544  LKINQAKPECGRQSLVELLIRPVQRLPSVALLLNDLKKHTADENPDKSTLEKAIGSLKEV 603

Query: 1352 IRDCNNNVQSMRRTEELIYLSQKIEFECKIFPLISQSRWLVKSGELTAL-EFSASPGLRR 1410
            +   N + +     +++  +  +++  C    L+S  R LV+  E  +L E     G   
Sbjct: 604  MTHINEDKRKTEAQKQIFDVVYEVD-GCPA-NLLSSHRSLVQRVETISLGEHPCDRG--- 658

Query: 1411 KLNTRPVHLHLFNDCLLLSRPR 1432
                  V L LFNDCL ++R R
Sbjct: 659  ----EQVTLFLFNDCLEIARKR 676


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 129/598 (21%), Positives = 194/598 (32%), Gaps = 61/598 (10%)

Query: 430  TQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESR 489
            TQ     T  +     P    PSL P   + +  SL  +  T     +    N Q     
Sbjct: 107  TQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDG 166

Query: 490  LRKGTVSSQGTEVVFASASVTPPRTPDSAPPSP-AEAYPITPASVSARPPV-AFPRRETS 547
              K T + +   +   SA    P +   A P+P AE     PA  + + P    P+   S
Sbjct: 167  KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS 226

Query: 548  CAARAPETA---SAPLSMDDPSPCGTSEMCPAALYGFPSTGTSP----PRPPANSTGTVQ 600
               + P      SAP +  +P+P  T           P+T   P    P+ PA +T    
Sbjct: 227  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT---- 282

Query: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
                   P    T+  P       +      P  P KPA     TP+    +     T +
Sbjct: 283  ----TKEPAPTTTKSAP-------TTPKEPAPTTPKKPA---PTTPKEPAPTTPKEPTPT 328

Query: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
                   T K+ +         P++P    P  +P  PA  T      ++P   +    +
Sbjct: 329  TPKEPAPTTKEPA---------PTTPKEPAP-TAPKKPAPTTPKEPAPTTPKEPAPTTTK 378

Query: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVV---PTLKQHSHPPPLALGSGLHAPHKGPLP 777
               P  P  P    T  +   T   A       PT  +   P             K P P
Sbjct: 379  EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT----------KEPAP 428

Query: 778  QA-SDPAVARQHRPLPSTPDSSHHAQATPR----WRYNKPLPPTPDLPQPHLPPISAPGS 832
                +PA     +P P+TP     A  TP+        KP P TP  P P  P  +AP +
Sbjct: 429  TTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 486

Query: 833  SRIYRPLPPLPII-DPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPA 891
             +   P  P  +    P +P P  P+    +             A T P       P   
Sbjct: 487  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-KE 545

Query: 892  SAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSK 951
             A  T   PA     E   +T +  +  +P            P++P  P   EL   T+K
Sbjct: 546  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605

Query: 952  DEAGVS-EHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR 1008
            +    + + P     +    TTP++ A    + P     +   P+ L  E A + P +
Sbjct: 606  EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKK 662



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 48/214 (22%), Positives = 67/214 (31%), Gaps = 12/214 (5%)

Query: 510 TPPRTPDSAPPS----PAEAYPITPASVSARPPVAFPRRETSCAARAPET--ASAPLSMD 563
           T P TP    P+    PA   P  PA     P        T+C   AP T   +AP +  
Sbjct: 570 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 629

Query: 564 DPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGML 623
           +P+P    E  P    G   T    P P        + L   +  G   T  T D     
Sbjct: 630 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP--TSTTSDKPAPT 687

Query: 624 LSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTAL--STLKQDSQESISNLE 681
                +    + P P       P          S VS   T    +T+ +   ES   L 
Sbjct: 688 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 747

Query: 682 RPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVS 715
              +P +++   SP  P   T      + P   +
Sbjct: 748 AEPTPKALEN--SPKEPGVPTTKTPAATKPEMTT 779



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 92/474 (19%), Positives = 151/474 (31%), Gaps = 77/474 (16%)

Query: 512 PRTPDS-APPSPAEAYPITPAS-VSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCG 569
           P TP+  AP +P E  P TP       P  A P      A   P+   AP +  +P+P  
Sbjct: 508 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK-EPAPTTPKEPAPTT 566

Query: 570 TSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHS 629
             E  P    G   T    P P        + L     P + +   +        +    
Sbjct: 567 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA----PTTTKEPTSTTCDKPAPTTPKG 622

Query: 630 ELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSI 689
             P  P +PA     TP       ++ +  +   TA +TLK+ +                
Sbjct: 623 TAPTTPKEPA---PTTP-------KEPAPTTPKGTAPTTLKEPAP--------------- 657

Query: 690 QPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVV 749
               +P  PA    +P     P+  + +         P P   ++T P+  +        
Sbjct: 658 ---TTPKKPAPKELAPTTTKGPTSTTSD--------KPAPTTPKETAPTTPKEPAPTTPK 706

Query: 750 VPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSH---HAQATPR 806
            P       PPP                + S P   ++   +  +PD S     A+ TP+
Sbjct: 707 KPAPTTPETPPPTT-------------SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 753

Query: 807 WRYNKPLPP------TPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRG 860
              N P  P      TP   +P +   +   ++   R L   P  +  T  P +  ++  
Sbjct: 754 ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE--RDLRTTP--ETTTAAPKMTKETAT 809

Query: 861 RSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS 920
            +  T    + +     T    QD T     +   T+  P    + ++ T+T        
Sbjct: 810 TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 869

Query: 921 PGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVS-EHPEAPAREPLRRTTP 973
                   TN       +   TP+ Q PT   +   S + P+   R    +TTP
Sbjct: 870 TAKPKDRATN-------SKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 916



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 21/185 (11%)

Query: 510 TPPRTP-DSAPPSPAEAYPITP---ASVSARPPVAFPRRETSCAARAPETASAPLS--MD 563
           T P TP + AP +P E  P TP   A  + + P     ++ +    AP T   P S   D
Sbjct: 623 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 682

Query: 564 DPSPCGTSEMCPAA-LYGFPSTGTSP----PRPPANSTGTVQHLRSDSFPGS-HRT--EQ 615
            P+P    E  P       P+T   P    P  P  +T  V    +   P + H++  E 
Sbjct: 683 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 742

Query: 616 TPDLVGMLLSYSHSELPQRPPKPAIYS-------SVTPRRDRRSGRDYSTVSASPTALST 668
           TP+L       +    P+ P  P   +         T  +D+ + RD  T   + TA   
Sbjct: 743 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 802

Query: 669 LKQDS 673
           + +++
Sbjct: 803 MTKET 807



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 72/390 (18%), Positives = 125/390 (32%), Gaps = 34/390 (8%)

Query: 433 PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRK 492
           P   T       +P   +P+         P     + L E +P        ++      K
Sbjct: 615 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 674

Query: 493 GTVSSQGTEVVFASASVTPPRTPD----SAPPSPAEAYPITPASVSARPPVAFPRRETSC 548
           G  S+   +    +   T P TP     + P  PA   P TP   ++        +E + 
Sbjct: 675 GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 734

Query: 549 AARAPETASAPLSMD-DPSPCGTSEMCPAALYGFPSTGT-SPPRPPANSTGTVQHLRSDS 606
             ++P+ ++  LS +  P     S   P    G P+T T +  +P   +T   +    D 
Sbjct: 735 IHKSPDESTPELSAEPTPKALENSPKEP----GVPTTKTPAATKPEMTTTAKDKTTERDL 790

Query: 607 FPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGR--DYSTVSASPT 664
                 T   P +     + +      +        + T  +D    +     T + +P 
Sbjct: 791 RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 850

Query: 665 ALSTLKQDSQESISNLERPSSPPSIQPWVS------PHNPAFATESPAYGSSPSFVSMED 718
             +T K  +   I N    ++ P  +   S      P  P  A + P     P  +    
Sbjct: 851 VTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMP--- 907

Query: 719 VRIHEPLPPPPPQR-RDTHPSVVETDGHARVVVPTLKQHSHPPPLAL-----------GS 766
            R+ +P   P P++   T P +  T   A  ++ T  + +  P   L           G+
Sbjct: 908 -RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 966

Query: 767 GLHAPHKGPLPQASDPAVARQHRPLPSTPD 796
               PH    P    P V      LP  P+
Sbjct: 967 EGETPHMLLRPHVFMPEVTPDMDYLPRVPN 996


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 129/598 (21%), Positives = 194/598 (32%), Gaps = 61/598 (10%)

Query: 430  TQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESR 489
            TQ     T  +     P    PSL P   + +  SL  +  T     +    N Q     
Sbjct: 148  TQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDG 207

Query: 490  LRKGTVSSQGTEVVFASASVTPPRTPDSAPPSP-AEAYPITPASVSARPPV-AFPRRETS 547
              K T + +   +   SA    P +   A P+P AE     PA  + + P    P+   S
Sbjct: 208  KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS 267

Query: 548  CAARAPETA---SAPLSMDDPSPCGTSEMCPAALYGFPSTGTSP----PRPPANSTGTVQ 600
               + P      SAP +  +P+P  T           P+T   P    P+ PA +T    
Sbjct: 268  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT---- 323

Query: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
                   P    T+  P       +      P  P KPA     TP+    +     T +
Sbjct: 324  ----TKEPAPTTTKSAP-------TTPKEPAPTTPKKPA---PTTPKEPAPTTPKEPTPT 369

Query: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
                   T K+ +         P++P    P  +P  PA  T      ++P   +    +
Sbjct: 370  TPKEPAPTTKEPA---------PTTPKEPAP-TAPKKPAPTTPKEPAPTTPKEPAPTTTK 419

Query: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVV---PTLKQHSHPPPLALGSGLHAPHKGPLP 777
               P  P  P    T  +   T   A       PT  +   P             K P P
Sbjct: 420  EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT----------KEPAP 469

Query: 778  QA-SDPAVARQHRPLPSTPDSSHHAQATPR----WRYNKPLPPTPDLPQPHLPPISAPGS 832
                +PA     +P P+TP     A  TP+        KP P TP  P P  P  +AP +
Sbjct: 470  TTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 527

Query: 833  SRIYRPLPPLPII-DPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPA 891
             +   P  P  +    P +P P  P+    +             A T P       P   
Sbjct: 528  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-KE 586

Query: 892  SAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSK 951
             A  T   PA     E   +T +  +  +P            P++P  P   EL   T+K
Sbjct: 587  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646

Query: 952  DEAGVS-EHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR 1008
            +    + + P     +    TTP++ A    + P     +   P+ L  E A + P +
Sbjct: 647  EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKK 703



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 48/214 (22%), Positives = 67/214 (31%), Gaps = 12/214 (5%)

Query: 510 TPPRTPDSAPPS----PAEAYPITPASVSARPPVAFPRRETSCAARAPET--ASAPLSMD 563
           T P TP    P+    PA   P  PA     P        T+C   AP T   +AP +  
Sbjct: 611 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 670

Query: 564 DPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGML 623
           +P+P    E  P    G   T    P P        + L   +  G   T  T D     
Sbjct: 671 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP--TSTTSDKPAPT 728

Query: 624 LSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTAL--STLKQDSQESISNLE 681
                +    + P P       P          S VS   T    +T+ +   ES   L 
Sbjct: 729 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 788

Query: 682 RPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVS 715
              +P +++   SP  P   T      + P   +
Sbjct: 789 AEPTPKALEN--SPKEPGVPTTKTPAATKPEMTT 820



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 92/474 (19%), Positives = 151/474 (31%), Gaps = 77/474 (16%)

Query: 512 PRTPDS-APPSPAEAYPITPAS-VSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCG 569
           P TP+  AP +P E  P TP       P  A P      A   P+   AP +  +P+P  
Sbjct: 549 PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK-EPAPTTPKEPAPTT 607

Query: 570 TSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHS 629
             E  P    G   T    P P        + L     P + +   +        +    
Sbjct: 608 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA----PTTTKEPTSTTCDKPAPTTPKG 663

Query: 630 ELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSI 689
             P  P +PA     TP       ++ +  +   TA +TLK+ +                
Sbjct: 664 TAPTTPKEPA---PTTP-------KEPAPTTPKGTAPTTLKEPAP--------------- 698

Query: 690 QPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVV 749
               +P  PA    +P     P+  + +         P P   ++T P+  +        
Sbjct: 699 ---TTPKKPAPKELAPTTTKGPTSTTSD--------KPAPTTPKETAPTTPKEPAPTTPK 747

Query: 750 VPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSH---HAQATPR 806
            P       PPP                + S P   ++   +  +PD S     A+ TP+
Sbjct: 748 KPAPTTPETPPPTT-------------SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 794

Query: 807 WRYNKPLPP------TPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRG 860
              N P  P      TP   +P +   +   ++   R L   P  +  T  P +  ++  
Sbjct: 795 ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE--RDLRTTP--ETTTAAPKMTKETAT 850

Query: 861 RSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS 920
            +  T    + +     T    QD T     +   T+  P    + ++ T+T        
Sbjct: 851 TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 910

Query: 921 PGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVS-EHPEAPAREPLRRTTP 973
                   TN       +   TP+ Q PT   +   S + P+   R    +TTP
Sbjct: 911 TAKPKDRATN-------SKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 957



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 21/185 (11%)

Query: 510 TPPRTP-DSAPPSPAEAYPITP---ASVSARPPVAFPRRETSCAARAPETASAPLS--MD 563
           T P TP + AP +P E  P TP   A  + + P     ++ +    AP T   P S   D
Sbjct: 664 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 723

Query: 564 DPSPCGTSEMCPAA-LYGFPSTGTSP----PRPPANSTGTVQHLRSDSFPGS-HRT--EQ 615
            P+P    E  P       P+T   P    P  P  +T  V    +   P + H++  E 
Sbjct: 724 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 783

Query: 616 TPDLVGMLLSYSHSELPQRPPKPAIYS-------SVTPRRDRRSGRDYSTVSASPTALST 668
           TP+L       +    P+ P  P   +         T  +D+ + RD  T   + TA   
Sbjct: 784 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 843

Query: 669 LKQDS 673
           + +++
Sbjct: 844 MTKET 848



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 72/390 (18%), Positives = 125/390 (32%), Gaps = 34/390 (8%)

Query: 433  PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRK 492
            P   T       +P   +P+         P     + L E +P        ++      K
Sbjct: 656  PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 715

Query: 493  GTVSSQGTEVVFASASVTPPRTPD----SAPPSPAEAYPITPASVSARPPVAFPRRETSC 548
            G  S+   +    +   T P TP     + P  PA   P TP   ++        +E + 
Sbjct: 716  GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 775

Query: 549  AARAPETASAPLSMD-DPSPCGTSEMCPAALYGFPSTGT-SPPRPPANSTGTVQHLRSDS 606
              ++P+ ++  LS +  P     S   P    G P+T T +  +P   +T   +    D 
Sbjct: 776  IHKSPDESTPELSAEPTPKALENSPKEP----GVPTTKTPAATKPEMTTTAKDKTTERDL 831

Query: 607  FPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGR--DYSTVSASPT 664
                  T   P +     + +      +        + T  +D    +     T + +P 
Sbjct: 832  RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 891

Query: 665  ALSTLKQDSQESISNLERPSSPPSIQPWVS------PHNPAFATESPAYGSSPSFVSMED 718
              +T K  +   I N    ++ P  +   S      P  P  A + P     P  +    
Sbjct: 892  VTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMP--- 948

Query: 719  VRIHEPLPPPPPQR-RDTHPSVVETDGHARVVVPTLKQHSHPPPLAL-----------GS 766
             R+ +P   P P++   T P +  T   A  ++ T  + +  P   L           G+
Sbjct: 949  -RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1007

Query: 767  GLHAPHKGPLPQASDPAVARQHRPLPSTPD 796
                PH    P    P V      LP  P+
Sbjct: 1008 EGETPHMLLRPHVFMPEVTPDMDYLPRVPN 1037


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 129/598 (21%), Positives = 194/598 (32%), Gaps = 61/598 (10%)

Query: 430  TQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESR 489
            TQ     T  +     P    PSL P   + +  SL  +  T     +    N Q     
Sbjct: 200  TQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDG 259

Query: 490  LRKGTVSSQGTEVVFASASVTPPRTPDSAPPSP-AEAYPITPASVSARPPV-AFPRRETS 547
              K T + +   +   SA    P +   A P+P AE     PA  + + P    P+   S
Sbjct: 260  KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS 319

Query: 548  CAARAPETA---SAPLSMDDPSPCGTSEMCPAALYGFPSTGTSP----PRPPANSTGTVQ 600
               + P      SAP +  +P+P  T           P+T   P    P+ PA +T    
Sbjct: 320  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT---- 375

Query: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
                   P    T+  P       +      P  P KPA     TP+    +     T +
Sbjct: 376  ----TKEPAPTTTKSAP-------TTPKEPAPTTPKKPA---PTTPKEPAPTTPKEPTPT 421

Query: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
                   T K+ +         P++P    P  +P  PA  T      ++P   +    +
Sbjct: 422  TPKEPAPTTKEPA---------PTTPKEPAP-TAPKKPAPTTPKEPAPTTPKEPAPTTTK 471

Query: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVV---PTLKQHSHPPPLALGSGLHAPHKGPLP 777
               P  P  P    T  +   T   A       PT  +   P             K P P
Sbjct: 472  EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT----------KEPAP 521

Query: 778  QA-SDPAVARQHRPLPSTPDSSHHAQATPR----WRYNKPLPPTPDLPQPHLPPISAPGS 832
                +PA     +P P+TP     A  TP+        KP P TP  P P  P  +AP +
Sbjct: 522  TTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 579

Query: 833  SRIYRPLPPLPII-DPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPA 891
             +   P  P  +    P +P P  P+    +             A T P       P   
Sbjct: 580  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-KE 638

Query: 892  SAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSK 951
             A  T   PA     E   +T +  +  +P            P++P  P   EL   T+K
Sbjct: 639  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 698

Query: 952  DEAGVS-EHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR 1008
            +    + + P     +    TTP++ A    + P     +   P+ L  E A + P +
Sbjct: 699  EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKK 755



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 105/519 (20%), Positives = 165/519 (31%), Gaps = 82/519 (15%)

Query: 544 RETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGF----------PSTGTSPPRPPA 593
           +E SC  R  E+       D  + C   + C      F          PS+  +PP   A
Sbjct: 25  QELSCKGRCFESFERGRECDCDAQCKKYDKCCPDYESFCAEVHNPTSPPSSKKAPPPSGA 84

Query: 594 NSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSG 653
           + T      RS   P   +T++  +   +   +S SE  +     +  SS +  R  +S 
Sbjct: 85  SQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSS 144

Query: 654 RDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESP-------- 705
           ++ S  +        +K + +        P  P   +      N  F   +P        
Sbjct: 145 KN-SAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHN 203

Query: 706 AYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV-----------------VETDG---- 744
              +SP   + + +     LPP     ++T  +V                   TDG    
Sbjct: 204 KVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKT 263

Query: 745 ------------HARVVVPTLKQHSHPPPLA----LGSGLHAPHKGPLPQASDPAVARQH 788
                        A+ + PT K  + P P A     G  L  P +       +PA     
Sbjct: 264 TSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPK 323

Query: 789 RPLPST------------PDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIY 836
            P P+T            P ++  A  TP+    +P P T   P P  P   AP +++  
Sbjct: 324 EPTPTTIKSAPTTPKEPAPTTTKSAPTTPK----EPAPTTTKEPAPTTPKEPAPTTTKEP 379

Query: 837 RPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRT 896
            P         P EP P  PK    +               T P     T   PA    T
Sbjct: 380 APTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--T 437

Query: 897 SWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGV 956
              PA     +   +T +  +  +P       T      SPTTP  P    PT+   A  
Sbjct: 438 PKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK---EPSPTTPKEP---APTTTKSAPT 491

Query: 957 SEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPS 995
           +    AP       TTP++ +    + P      P++P+
Sbjct: 492 TTKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 528



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 48/214 (22%), Positives = 67/214 (31%), Gaps = 12/214 (5%)

Query: 510 TPPRTPDSAPPS----PAEAYPITPASVSARPPVAFPRRETSCAARAPET--ASAPLSMD 563
           T P TP    P+    PA   P  PA     P        T+C   AP T   +AP +  
Sbjct: 663 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 722

Query: 564 DPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGML 623
           +P+P    E  P    G   T    P P        + L   +  G   T  T D     
Sbjct: 723 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP--TSTTSDKPAPT 780

Query: 624 LSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTAL--STLKQDSQESISNLE 681
                +    + P P       P          S VS   T    +T+ +   ES   L 
Sbjct: 781 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 840

Query: 682 RPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVS 715
              +P +++   SP  P   T      + P   +
Sbjct: 841 AEPTPKALEN--SPKEPGVPTTKTPAATKPEMTT 872



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 92/474 (19%), Positives = 151/474 (31%), Gaps = 77/474 (16%)

Query: 512  PRTPDS-APPSPAEAYPITPAS-VSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCG 569
            P TP+  AP +P E  P TP       P  A P      A   P+   AP +  +P+P  
Sbjct: 601  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK-EPAPTTPKEPAPTT 659

Query: 570  TSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHS 629
              E  P    G   T    P P        + L     P + +   +        +    
Sbjct: 660  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA----PTTTKEPTSTTCDKPAPTTPKG 715

Query: 630  ELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSI 689
              P  P +PA     TP       ++ +  +   TA +TLK+ +                
Sbjct: 716  TAPTTPKEPA---PTTP-------KEPAPTTPKGTAPTTLKEPAP--------------- 750

Query: 690  QPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVV 749
                +P  PA    +P     P+  + +         P P   ++T P+  +        
Sbjct: 751  ---TTPKKPAPKELAPTTTKGPTSTTSD--------KPAPTTPKETAPTTPKEPAPTTPK 799

Query: 750  VPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSH---HAQATPR 806
             P       PPP                + S P   ++   +  +PD S     A+ TP+
Sbjct: 800  KPAPTTPETPPPTT-------------SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 846

Query: 807  WRYNKPLPP------TPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRG 860
               N P  P      TP   +P +   +   ++   R L   P  +  T  P +  ++  
Sbjct: 847  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE--RDLRTTP--ETTTAAPKMTKETAT 902

Query: 861  RSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS 920
             +  T    + +     T    QD T     +   T+  P    + ++ T+T        
Sbjct: 903  TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 962

Query: 921  PGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVS-EHPEAPAREPLRRTTP 973
                    TN       +   TP+ Q PT   +   S + P+   R    +TTP
Sbjct: 963  TAKPKDRATN-------SKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1009



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 21/185 (11%)

Query: 510 TPPRTP-DSAPPSPAEAYPITP---ASVSARPPVAFPRRETSCAARAPETASAPLS--MD 563
           T P TP + AP +P E  P TP   A  + + P     ++ +    AP T   P S   D
Sbjct: 716 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 775

Query: 564 DPSPCGTSEMCPAA-LYGFPSTGTSP----PRPPANSTGTVQHLRSDSFPGS-HRT--EQ 615
            P+P    E  P       P+T   P    P  P  +T  V    +   P + H++  E 
Sbjct: 776 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 835

Query: 616 TPDLVGMLLSYSHSELPQRPPKPAIYS-------SVTPRRDRRSGRDYSTVSASPTALST 668
           TP+L       +    P+ P  P   +         T  +D+ + RD  T   + TA   
Sbjct: 836 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 895

Query: 669 LKQDS 673
           + +++
Sbjct: 896 MTKET 900



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 72/390 (18%), Positives = 125/390 (32%), Gaps = 34/390 (8%)

Query: 433  PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRK 492
            P   T       +P   +P+         P     + L E +P        ++      K
Sbjct: 708  PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 767

Query: 493  GTVSSQGTEVVFASASVTPPRTPD----SAPPSPAEAYPITPASVSARPPVAFPRRETSC 548
            G  S+   +    +   T P TP     + P  PA   P TP   ++        +E + 
Sbjct: 768  GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827

Query: 549  AARAPETASAPLSMD-DPSPCGTSEMCPAALYGFPSTGT-SPPRPPANSTGTVQHLRSDS 606
              ++P+ ++  LS +  P     S   P    G P+T T +  +P   +T   +    D 
Sbjct: 828  IHKSPDESTPELSAEPTPKALENSPKEP----GVPTTKTPAATKPEMTTTAKDKTTERDL 883

Query: 607  FPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGR--DYSTVSASPT 664
                  T   P +     + +      +        + T  +D    +     T + +P 
Sbjct: 884  RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 943

Query: 665  ALSTLKQDSQESISNLERPSSPPSIQPWVS------PHNPAFATESPAYGSSPSFVSMED 718
              +T K  +   I N    ++ P  +   S      P  P  A + P     P  +    
Sbjct: 944  VTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMP--- 1000

Query: 719  VRIHEPLPPPPPQR-RDTHPSVVETDGHARVVVPTLKQHSHPPPLAL-----------GS 766
             R+ +P   P P++   T P +  T   A  ++ T  + +  P   L           G+
Sbjct: 1001 -RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1059

Query: 767  GLHAPHKGPLPQASDPAVARQHRPLPSTPD 796
                PH    P    P V      LP  P+
Sbjct: 1060 EGETPHMLLRPHVFMPEVTPDMDYLPRVPN 1089


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 129/598 (21%), Positives = 194/598 (32%), Gaps = 61/598 (10%)

Query: 430  TQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESR 489
            TQ     T  +     P    PSL P   + +  SL  +  T     +    N Q     
Sbjct: 241  TQHNKVSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDG 300

Query: 490  LRKGTVSSQGTEVVFASASVTPPRTPDSAPPSP-AEAYPITPASVSARPPV-AFPRRETS 547
              K T + +   +   SA    P +   A P+P AE     PA  + + P    P+   S
Sbjct: 301  KEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPAS 360

Query: 548  CAARAPETA---SAPLSMDDPSPCGTSEMCPAALYGFPSTGTSP----PRPPANSTGTVQ 600
               + P      SAP +  +P+P  T           P+T   P    P+ PA +T    
Sbjct: 361  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT---- 416

Query: 601  HLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
                   P    T+  P       +      P  P KPA     TP+    +     T +
Sbjct: 417  ----TKEPAPTTTKSAP-------TTPKEPAPTTPKKPA---PTTPKEPAPTTPKEPTPT 462

Query: 661  ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
                   T K+ +         P++P    P  +P  PA  T      ++P   +    +
Sbjct: 463  TPKEPAPTTKEPA---------PTTPKEPAP-TAPKKPAPTTPKEPAPTTPKEPAPTTTK 512

Query: 721  IHEPLPPPPPQRRDTHPSVVETDGHARVVV---PTLKQHSHPPPLALGSGLHAPHKGPLP 777
               P  P  P    T  +   T   A       PT  +   P             K P P
Sbjct: 513  EPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT----------KEPAP 562

Query: 778  QA-SDPAVARQHRPLPSTPDSSHHAQATPR----WRYNKPLPPTPDLPQPHLPPISAPGS 832
                +PA     +P P+TP     A  TP+        KP P TP  P P  P  +AP +
Sbjct: 563  TTPKEPAPTTPKKPAPTTPKEP--APTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 620

Query: 833  SRIYRPLPPLPII-DPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPA 891
             +   P  P  +    P +P P  P+    +             A T P       P   
Sbjct: 621  PKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP-KE 679

Query: 892  SAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSK 951
             A  T   PA     E   +T +  +  +P            P++P  P   EL   T+K
Sbjct: 680  PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 739

Query: 952  DEAGVS-EHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR 1008
            +    + + P     +    TTP++ A    + P     +   P+ L  E A + P +
Sbjct: 740  EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKK 796



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 105/518 (20%), Positives = 164/518 (31%), Gaps = 82/518 (15%)

Query: 545 ETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGF----------PSTGTSPPRPPAN 594
           E SC  R  E+       D  + C   + C      F          PS+  +PP   A+
Sbjct: 67  ELSCKGRCFESFERGRECDCDAQCKKYDKCCPDYESFCAEVHNPTSPPSSKKAPPPSGAS 126

Query: 595 STGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGR 654
            T      RS   P   +T++  +   +   +S SE  +     +  SS +  R  +S +
Sbjct: 127 QTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSK 186

Query: 655 DYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESP--------A 706
           + S  +        +K + +        P  P   +      N  F   +P         
Sbjct: 187 N-SAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNK 245

Query: 707 YGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV-----------------VETDG----- 744
             +SP   + + +     LPP     ++T  +V                   TDG     
Sbjct: 246 VSTSPKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTT 305

Query: 745 -----------HARVVVPTLKQHSHPPPLA----LGSGLHAPHKGPLPQASDPAVARQHR 789
                       A+ + PT K  + P P A     G  L  P +       +PA      
Sbjct: 306 SAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKE 365

Query: 790 PLPST------------PDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYR 837
           P P+T            P ++  A  TP+    +P P T   P P  P   AP +++   
Sbjct: 366 PTPTTIKSAPTTPKEPAPTTTKSAPTTPK----EPAPTTTKEPAPTTPKEPAPTTTKEPA 421

Query: 838 PLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTS 897
           P         P EP P  PK    +               T P     T   PA    T 
Sbjct: 422 PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPT--TP 479

Query: 898 WPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVS 957
             PA     +   +T +  +  +P       T      SPTTP  P    PT+   A  +
Sbjct: 480 KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTK---EPSPTTPKEP---APTTTKSAPTT 533

Query: 958 EHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPS 995
               AP       TTP++ +    + P      P++P+
Sbjct: 534 TKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 569



 Score = 44.7 bits (104), Expect = 7e-04
 Identities = 48/214 (22%), Positives = 67/214 (31%), Gaps = 12/214 (5%)

Query: 510 TPPRTPDSAPPS----PAEAYPITPASVSARPPVAFPRRETSCAARAPET--ASAPLSMD 563
           T P TP    P+    PA   P  PA     P        T+C   AP T   +AP +  
Sbjct: 704 TAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 763

Query: 564 DPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGML 623
           +P+P    E  P    G   T    P P        + L   +  G   T  T D     
Sbjct: 764 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGP--TSTTSDKPAPT 821

Query: 624 LSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTAL--STLKQDSQESISNLE 681
                +    + P P       P          S VS   T    +T+ +   ES   L 
Sbjct: 822 TPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELS 881

Query: 682 RPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVS 715
              +P +++   SP  P   T      + P   +
Sbjct: 882 AEPTPKALEN--SPKEPGVPTTKTPAATKPEMTT 913



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 92/474 (19%), Positives = 151/474 (31%), Gaps = 77/474 (16%)

Query: 512  PRTPDS-APPSPAEAYPITPAS-VSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCG 569
            P TP+  AP +P E  P TP       P  A P      A   P+   AP +  +P+P  
Sbjct: 642  PTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPK-EPAPTTPKEPAPTT 700

Query: 570  TSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHS 629
              E  P    G   T    P P        + L     P + +   +        +    
Sbjct: 701  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA----PTTTKEPTSTTCDKPAPTTPKG 756

Query: 630  ELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSI 689
              P  P +PA     TP       ++ +  +   TA +TLK+ +                
Sbjct: 757  TAPTTPKEPA---PTTP-------KEPAPTTPKGTAPTTLKEPAP--------------- 791

Query: 690  QPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVV 749
                +P  PA    +P     P+  + +         P P   ++T P+  +        
Sbjct: 792  ---TTPKKPAPKELAPTTTKGPTSTTSD--------KPAPTTPKETAPTTPKEPAPTTPK 840

Query: 750  VPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSH---HAQATPR 806
             P       PPP                + S P   ++   +  +PD S     A+ TP+
Sbjct: 841  KPAPTTPETPPPTT-------------SEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK 887

Query: 807  WRYNKPLPP------TPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRG 860
               N P  P      TP   +P +   +   ++   R L   P  +  T  P +  ++  
Sbjct: 888  ALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTE--RDLRTTP--ETTTAAPKMTKETAT 943

Query: 861  RSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVS 920
             +  T    + +     T    QD T     +   T+  P    + ++ T+T        
Sbjct: 944  TTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEE 1003

Query: 921  PGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVS-EHPEAPAREPLRRTTP 973
                    TN       +   TP+ Q PT   +   S + P+   R    +TTP
Sbjct: 1004 TAKPKDRATN-------SKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTP 1050



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 21/185 (11%)

Query: 510 TPPRTP-DSAPPSPAEAYPITP---ASVSARPPVAFPRRETSCAARAPETASAPLS--MD 563
           T P TP + AP +P E  P TP   A  + + P     ++ +    AP T   P S   D
Sbjct: 757 TAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSD 816

Query: 564 DPSPCGTSEMCPAA-LYGFPSTGTSP----PRPPANSTGTVQHLRSDSFPGS-HRT--EQ 615
            P+P    E  P       P+T   P    P  P  +T  V    +   P + H++  E 
Sbjct: 817 KPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES 876

Query: 616 TPDLVGMLLSYSHSELPQRPPKPAIYS-------SVTPRRDRRSGRDYSTVSASPTALST 668
           TP+L       +    P+ P  P   +         T  +D+ + RD  T   + TA   
Sbjct: 877 TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPK 936

Query: 669 LKQDS 673
           + +++
Sbjct: 937 MTKET 941



 Score = 38.9 bits (89), Expect = 0.040
 Identities = 72/390 (18%), Positives = 125/390 (32%), Gaps = 34/390 (8%)

Query: 433  PGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRK 492
            P   T       +P   +P+         P     + L E +P        ++      K
Sbjct: 749  PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 808

Query: 493  GTVSSQGTEVVFASASVTPPRTPD----SAPPSPAEAYPITPASVSARPPVAFPRRETSC 548
            G  S+   +    +   T P TP     + P  PA   P TP   ++        +E + 
Sbjct: 809  GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868

Query: 549  AARAPETASAPLSMD-DPSPCGTSEMCPAALYGFPSTGT-SPPRPPANSTGTVQHLRSDS 606
              ++P+ ++  LS +  P     S   P    G P+T T +  +P   +T   +    D 
Sbjct: 869  IHKSPDESTPELSAEPTPKALENSPKEP----GVPTTKTPAATKPEMTTTAKDKTTERDL 924

Query: 607  FPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGR--DYSTVSASPT 664
                  T   P +     + +      +        + T  +D    +     T + +P 
Sbjct: 925  RTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPK 984

Query: 665  ALSTLKQDSQESISNLERPSSPPSIQPWVS------PHNPAFATESPAYGSSPSFVSMED 718
              +T K  +   I N    ++ P  +   S      P  P  A + P     P  +    
Sbjct: 985  VTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMP--- 1041

Query: 719  VRIHEPLPPPPPQR-RDTHPSVVETDGHARVVVPTLKQHSHPPPLAL-----------GS 766
             R+ +P   P P++   T P +  T   A  ++ T  + +  P   L           G+
Sbjct: 1042 -RVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGA 1100

Query: 767  GLHAPHKGPLPQASDPAVARQHRPLPSTPD 796
                PH    P    P V      LP  P+
Sbjct: 1101 EGETPHMLLRPHVFMPEVTPDMDYLPRVPN 1130


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 102/443 (23%), Positives = 142/443 (32%), Gaps = 86/443 (19%)

Query: 506  SASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDP 565
            + + TPP T   +PP      P  P + +  PP++              T + P     P
Sbjct: 1427 TTTTTPPPTTTPSPPITTTTTP--PPTTTPSPPIS--------------TTTTPPPTTTP 1470

Query: 566  SPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLS 625
            SP  T+          PS  T+ P PP  +T T     + S P +  T  TP      L 
Sbjct: 1471 SPPTTT----------PSPPTTTPSPPTTTTTTPPPTTTPSPPTT--TPITPPASTTTLP 1518

Query: 626  YSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSS 685
                  P   P P   ++ TP          +T    PT+ +TL             P++
Sbjct: 1519 ------PTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP------------PTT 1560

Query: 686  PPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGH 745
             PS  P  +   P   T SP   ++PS  ++           PPP    + P+   T   
Sbjct: 1561 TPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTT-------TPPPTTTPSPPTTTTTT-- 1611

Query: 746  ARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATP 805
                         PPP    S        P      P  +    P  +TP        TP
Sbjct: 1612 -------------PPPTTTPS-------PPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP 1651

Query: 806  RWRYNKPLPPTPDLPQPHL------PPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSR 859
                  P PPT   P P +      PP + P S     P PP   +  P+  P   P S 
Sbjct: 1652 P-PTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPS--PTTTPSSP 1708

Query: 860  GRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEV 919
              + +T            T       T P P +   T+ PP T  S    T+T    S  
Sbjct: 1709 ITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSS--PLTTTPLPPSIT 1766

Query: 920  SPGMAFSNMTNFLCPSSPTTPWT 942
             P  +  + T    P  P   WT
Sbjct: 1767 PPTFSPFSTTTPTTPCVPLCNWT 1789



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 91/403 (22%), Positives = 123/403 (30%), Gaps = 76/403 (18%)

Query: 582  PSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIY 641
            PS  T+ P PP  ST T+    + S P +  T  TP              P   P P I 
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTT--TTTTPP-------------PTTTPSPPIT 1443

Query: 642  SSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFA 701
            ++ TP          ST +  P   +               P++ PS  P  +P  P   
Sbjct: 1444 TTTTPPPTTTPSPPISTTTTPPPTTTP------------SPPTTTPS-PPTTTPSPPTTT 1490

Query: 702  TESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPP 761
            T +P   ++PS               PP     T P+   T        P     + PPP
Sbjct: 1491 TTTPPPTTTPS---------------PPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPP 1535

Query: 762  LALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQ 821
                S        P      P  +    P  +TP        TP      P PPT   P 
Sbjct: 1536 TTTPSP-------PTTTPITPPTSTTTLPPTTTPSPPPTTTTTPP-PTTTPSPPTTTTPS 1587

Query: 822  PHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPA 881
            P     + P         PP     PPT     PP +   S  T              P 
Sbjct: 1588 PPTITTTTP---------PPTTTPSPPTTTTTTPPPTTTPSPPTT---------TPITPP 1629

Query: 882  CQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPW 941
                T+P P +   T  PP T  +T   T+T    +  +P    +  T    P   TTP 
Sbjct: 1630 TSTTTLP-PTT---TPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTT---PPPTTTPS 1682

Query: 942  TPELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSP 984
            +P    P+       +  P      P+  TT     + P   P
Sbjct: 1683 SPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPP 1725



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 89/397 (22%), Positives = 123/397 (30%), Gaps = 59/397 (14%)

Query: 405  PSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPIS 464
            PS P        P     P  S   T  P T         SP   +PS      +  P +
Sbjct: 1438 PSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPT 1497

Query: 465  LLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAE 524
                  T  SP            + L   T  S  T         T P  P + P +P  
Sbjct: 1498 ------TTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP-- 1549

Query: 525  AYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPST 584
                 P S +  PP   P       +  P T + P     PSP  T+   P  +      
Sbjct: 1550 -----PTSTTTLPPTTTP-------SPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPP 1597

Query: 585  GTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSV 644
             T+ P PP  +T T     + S P +  T  TP      L       P   P P   ++ 
Sbjct: 1598 PTTTPSPPTTTTTTPPPTTTPSPPTT--TPITPPTSTTTLP------PTTTPSPPPTTTT 1649

Query: 645  TPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSI-----QPWVSPHNPA 699
            TP          +T  + P   +T    +    S +    SPP+       P  +P +P 
Sbjct: 1650 TPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPI 1709

Query: 700  FATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHP 759
              T +P+  ++PS                PP    T PS   T       + TL      
Sbjct: 1710 TTTTTPSSTTTPS----------------PPPTTMTTPSPTTTPSPPTTTMTTL------ 1747

Query: 760  PPLALGSGLHAPHKGPLPQA-SDPAVARQHRPLPSTP 795
            PP    S L      PLP + + P  +      P+TP
Sbjct: 1748 PPTTTSSPLTTT---PLPPSITPPTFSPFSTTTPTTP 1781



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 91/472 (19%), Positives = 150/472 (31%), Gaps = 29/472 (6%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 3836 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 3891

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 3892 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 3949

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 3950 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4009

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 4010 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 4063

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGLH---APHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 4064 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 4122

Query: 797  SSHHAQATPRWRYNKPLP-PTPDLPQ-PHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPL 854
             +     TP        P PTP   Q P   PI+   ++    P P       PT  P  
Sbjct: 4123 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT---TTTTVTPTPTPTGTQTPTTTPIT 4179

Query: 855  PPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTES-FTSTS 913
               +   + +  G       H  T P  +  T   P  +      P T+RST S  T ++
Sbjct: 4180 TTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESST----PQTSRSTSSPLTEST 4235

Query: 914  RSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAR 965
               S + P +    MT+   PS+PT P T       S   +  +  P  P R
Sbjct: 4236 TLLSTLPPAI---EMTSTAPPSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTR 4284



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 92/495 (18%), Positives = 153/495 (30%), Gaps = 62/495 (12%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 3951 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 4006

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 4007 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 4064

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 4065 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4124

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 4125 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 4178

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSH 799
              T        PT  Q   P   +           P P++S P  +R     P T  ++ 
Sbjct: 4179 TTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRS-TSSPLTESTTL 4237

Query: 800  HAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSR 859
             +   P        PP+     P  P  ++ G +     L P P     T PP  P  +R
Sbjct: 4238 LSTLPPAIEMTSTAPPS----TPTAPTTTSGGHT-----LSPPP--STTTSPPGTP--TR 4284

Query: 860  GRSRSTRGGHMNSGGHAKTRPACQDWT-VPLPASAGRTSWPPATARSTESFTSTSR---- 914
            G +  +      S     T  A   WT  P P S       P+  R+T      S     
Sbjct: 4285 GTTTGSSSAPTPSTVQTTTTSA---WTPTPTPLST------PSIIRTTGLRPYPSSVLIC 4335

Query: 915  ---SKSEVSPGMAFSNMT-------------------NFLCPSSPTTPWTPELQGPTSKD 952
               + +  +PG    N T                   N+ CPS+P+   TP    PT   
Sbjct: 4336 CVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWSCPSTPSPTPTPSKSTPTPSK 4395

Query: 953  EAGVSEHPEAPAREP 967
             +     P    + P
Sbjct: 4396 PSSTPSKPTPGTKPP 4410



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 79/476 (16%), Positives = 139/476 (29%), Gaps = 17/476 (3%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 1904 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 1959

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 1960 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 2017

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 2018 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2077

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 2078 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2131

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGL---HAPHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 2132 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 2190

Query: 797  SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
             +     TP       + PTP       P  +   ++    P P       PT  P    
Sbjct: 2191 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2249

Query: 857  KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSK 916
             +   + +  G    +     T         P       T+    T   T + T T    
Sbjct: 2250 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2309

Query: 917  SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT 972
               +P    + +T    P+   TP T  +   T+          + P   P+  TT
Sbjct: 2310 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2365



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 79/476 (16%), Positives = 139/476 (29%), Gaps = 17/476 (3%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 2318 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 2373

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 2374 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 2431

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 2432 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2491

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 2492 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2545

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGL---HAPHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 2546 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 2604

Query: 797  SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
             +     TP       + PTP       P  +   ++    P P       PT  P    
Sbjct: 2605 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 2663

Query: 857  KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSK 916
             +   + +  G    +     T         P       T+    T   T + T T    
Sbjct: 2664 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 2723

Query: 917  SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT 972
               +P    + +T    P+   TP T  +   T+          + P   P+  TT
Sbjct: 2724 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 2779



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 79/476 (16%), Positives = 139/476 (29%), Gaps = 17/476 (3%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 2732 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 2787

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 2788 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 2845

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 2846 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2905

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 2906 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 2959

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGL---HAPHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 2960 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 3018

Query: 797  SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
             +     TP       + PTP       P  +   ++    P P       PT  P    
Sbjct: 3019 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3077

Query: 857  KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSK 916
             +   + +  G    +     T         P       T+    T   T + T T    
Sbjct: 3078 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3137

Query: 917  SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT 972
               +P    + +T    P+   TP T  +   T+          + P   P+  TT
Sbjct: 3138 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3193



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 79/476 (16%), Positives = 139/476 (29%), Gaps = 17/476 (3%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 3146 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 3201

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 3202 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 3259

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 3260 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3319

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 3320 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3373

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGL---HAPHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 3374 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 3432

Query: 797  SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
             +     TP       + PTP       P  +   ++    P P       PT  P    
Sbjct: 3433 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3491

Query: 857  KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSK 916
             +   + +  G    +     T         P       T+    T   T + T T    
Sbjct: 3492 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3551

Query: 917  SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT 972
               +P    + +T    P+   TP T  +   T+          + P   P+  TT
Sbjct: 3552 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 3607



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 79/476 (16%), Positives = 139/476 (29%), Gaps = 17/476 (3%)

Query: 500  TEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAP 559
            T  V  + + T  +TP + P +       TP     + P   P   T+     P     P
Sbjct: 3560 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TP 3615

Query: 560  LSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDL 619
                 P+    +          P+   +P   P  +T TV    + +  G+     TP  
Sbjct: 3616 TGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT--GTQTPTTTPIT 3673

Query: 620  VGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISN 679
                ++ + +    + P     ++ T      +     T + +P   +T    +      
Sbjct: 3674 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3733

Query: 680  LERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSV 739
                ++P +    V+P      T +P    +P+   +       P P P   +  T   +
Sbjct: 3734 QTPTTTPITTTTTVTP------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPI 3787

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGL---HAPHKGPLPQASDPAVARQHRPLPSTPD 796
              T        PT  Q     P+   + +     P     P  +         P P TP 
Sbjct: 3788 TTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP-TPT 3846

Query: 797  SSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
             +     TP       + PTP       P  +   ++    P P       PT  P    
Sbjct: 3847 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 3905

Query: 857  KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSK 916
             +   + +  G    +     T         P       T+    T   T + T T    
Sbjct: 3906 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 3965

Query: 917  SEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT 972
               +P    + +T    P+   TP T  +   T+          + P   P+  TT
Sbjct: 3966 PTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTT 4021



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 30/131 (22%), Positives = 50/131 (38%), Gaps = 6/131 (4%)

Query: 430  TQIPGTQTESRAEELSPAALSPSLE---PIRCSHQPISLLGSFLTEESPDKEIDQNSQQE 486
            TQ P T   +    ++P       +   P   S  PI+ L +  +   P+    Q S+  
Sbjct: 4170 TQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTT--SNPPPESSTPQTSRST 4227

Query: 487  ESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRET 546
             S L + T             S  PP TP +AP + +  + ++P   +   P   P R T
Sbjct: 4228 SSPLTESTTLLSTLPPAIEMTSTAPPSTP-TAPTTTSGGHTLSPPPSTTTSPPGTPTRGT 4286

Query: 547  SCAARAPETAS 557
            +  + +  T S
Sbjct: 4287 TTGSSSAPTPS 4297


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 79/262 (30%), Positives = 117/262 (44%), Gaps = 35/262 (13%)

Query: 162  GSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGL 221
            G G+ EEEEE               EE   E  + EG E     +GEE   E   E +G 
Sbjct: 822  GKGEREEEEEEGEGEE---------EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEG- 871

Query: 222  LHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQD 281
                E +  EE+G+ E    GEG   E+   +G  GEE+   +  +E+GE K ++E  + 
Sbjct: 872  -EEGEGEGEEEEGEGEGEEEGEGEGEEEE-GEGE-GEEEGEGEGEEEEGEGKGEEEGEEG 928

Query: 282  VMLGRQ--GERMGLTGEPEGLND-GEWEQEDMERKAQGQG--------GPEQGEERKREL 330
               G +  GE  G  GE EG  + GEWE E+ E + +G+         G  +GEE + E 
Sbjct: 929  EGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988

Query: 331  QVPEENRADSQDEKSQTFLGKSE-EVTGKQEDHGIKE---KGVPVSGQEAKEPESWDGGR 386
            +  EE   +  +E+ +   G+ E E  G++E+ G  E   +G    G+  +E    +G  
Sbjct: 989  EGEEEEGEEEGEEEGE---GEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045

Query: 387  LGAVGRA----RSREEENEHHG 404
                G      R+REEE E  G
Sbjct: 1046 REKEGEGEENRRNREEEEEEEG 1067



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 70/242 (28%), Positives = 112/242 (46%), Gaps = 13/242 (5%)

Query: 167 EEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQE 226
           +E EE   +  G+        E   E  + EG E G   +GEE+  E  +E +G    +E
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEE-KEGEGKEEG---EGEEVEGEREKE-EGERKKEE 779

Query: 227 VQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIE--QVNDEKGEQKQKQEQVQ-DVM 283
               EE+G++E G +GEG   E         E   +E  +V + KGE+++++E+ + +  
Sbjct: 780 RAGKEEKGEEE-GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838

Query: 284 LGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADSQDE 343
            G   E  G   E EG   GE E E+ E + +G+ G  +GEE + E +  EE   + ++E
Sbjct: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898

Query: 344 KSQTFLGKSEEV-TGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEH 402
           + +   G+ EE   G+ E+   + KG     +   E E  +G   G  G     EEE E 
Sbjct: 899 EGE---GEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW 955

Query: 403 HG 404
            G
Sbjct: 956 EG 957



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 69/268 (25%), Positives = 119/268 (44%), Gaps = 14/268 (5%)

Query: 144  GSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGT 203
            G  EEE E   G      G  +  E EE   +  G+        E   E  + EG E   
Sbjct: 824  GEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEG 883

Query: 204  IRQGEELPPEELQESQGLLHPQEV---QVLEEQGQ---QEAGFRGEGTLREDVC-ADGLL 256
              +GEE    E +E +G    +E    +  EE+G+   +E G  GEG   E+    +G  
Sbjct: 884  EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGED 943

Query: 257  GEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEG-LNDGEWEQEDMERKAQ 315
            GE +  E+  + +GE+++ + + ++     +GE  G  GE EG   +GE E E+ E + +
Sbjct: 944  GEGEGEEEEGEWEGEEEEGEGEGEE-----EGEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998

Query: 316  GQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQE 375
            G+   E  EE + E +  EE   + + E  +   G+ EE  G++E    +++G     + 
Sbjct: 999  GEEEGEGEEEGEGEGEEEEEGEVEGEVE-GEEGEGEGEEEEGEEEGEEREKEGEGEENRR 1057

Query: 376  AKEPESWDGGRLGAVGRARSREEENEHH 403
             +E E  + G+    G   +  ++ E +
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEEY 1085



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 102/420 (24%), Positives = 163/420 (38%), Gaps = 45/420 (10%)

Query: 13  PISAIEEFSI----IPEAPMRSSQVSALGLEAQEDEDPSYKWREEHRLSATQQSELRDVC 68
           P + IE FS     IPE    +      G+E QE E      +         +    D+ 
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631

Query: 69  DYAIETMPSFPKEGSADVEPNQ--ESLVAEACDTPEHWEAVPQSLA------------GR 114
           D A  +       G A+  P    +    E     EHW+   +               G 
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE 691

Query: 115 QARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLTLGSGQAEE-EEETS 173
             + LA  E W    + +  +      + G ++E  +          G G+ EE + E  
Sbjct: 692 GEKELAEKEEWK---KRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEE 748

Query: 174 SDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGLLHPQEV----QV 229
            +  G+ +     EE   E  + EG      R G+E   EE +  QG    +E     + 
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEE-EGDQGEGEEEETEGRGEE 807

Query: 230 LEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGE 289
            EE G+ E G   EG    +   +   GEE+  E   +E+GE ++++ + +    G +GE
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG-EEEEGEGEEEEGEGKGEEEGEEGE 866

Query: 290 RMGLTGEPEGLNDGEWEQEDMERKAQG-QGGPEQGEERKRELQVPEENRADSQDEKSQTF 348
                GE EG  +GE E E+ E + +G + G  +GEE + E +  EE   + ++E+ +  
Sbjct: 867 -----GEEEG-EEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGE-- 918

Query: 349 LGKSEEVTGKQEDHGIKE----KGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHG 404
            GK EE   + E  G +E    +G    G+  +E   W+G      G     EEE E  G
Sbjct: 919 -GKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEG---EEEGEGEG 974



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 70/247 (28%), Positives = 111/247 (44%), Gaps = 27/247 (10%)

Query: 144  GSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAE-TNQNEGSESG 202
            G  EEE E   G      G G+ EEEE    +  G+       EE   E   + EG   G
Sbjct: 856  GKGEEEGEEGEGEEEGEEGEGEGEEEE---GEGEGEEEGEGEGEEEEGEGEGEEEGEGEG 912

Query: 203  TIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMI 262
               +GE    EE +E +G     E +  E +G+ E G  GEG   E        GEE+  
Sbjct: 913  EEEEGEGKGEEEGEEGEG-----EGEEEEGEGEGEDG-EGEGEEEEGEWE----GEEEEG 962

Query: 263  EQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQE-----------DME 311
            E   +E+GE + ++ + +      +GE     GE EG  +GE E+E           ++E
Sbjct: 963  EGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVE 1022

Query: 312  RKAQGQGGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPV 371
             + +G+ G  +GEE + E +  EE   + + E+++    + EE  GK ++ G +E+    
Sbjct: 1023 GEVEGEEGEGEGEEEEGE-EEGEEREKEGEGEENRRNREEEEEEEGKYQETG-EEENERQ 1080

Query: 372  SGQEAKE 378
             G+E K+
Sbjct: 1081 DGEEYKK 1087



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 74/270 (27%), Positives = 116/270 (42%), Gaps = 35/270 (12%)

Query: 163  SGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSE--SGTIRQGEELPPEELQESQG 220
            +G+ E+ EE      G+        E   E  + EG E   G   + EE    E +E +G
Sbjct: 781  AGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEG 840

Query: 221  LLHPQEVQVLEEQGQ------------QEAGFRGEGTLREDVC-------ADGLLGEEQM 261
                +E +  EE+G+            +E G  GEG   E+          +G  GEE+ 
Sbjct: 841  EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG-EGEEEE 899

Query: 262  IEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEG-LNDGEWEQEDMERKAQGQGGP 320
             E   +E+GE + ++E+ +      +GE  G  GE EG   +GE E ED E + + + G 
Sbjct: 900  GEGEGEEEGEGEGEEEEGEG-----KGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954

Query: 321  EQGEERKRELQVPEENRADSQ------DEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQ 374
             +GEE + E +  EE   + +      +E+     G+ EE   + E+ G  E+     G+
Sbjct: 955  WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014

Query: 375  EAKEPESWDGGRLGAVGRARSREEENEHHG 404
            E +E E  +G   G  G     EEE E  G
Sbjct: 1015 EEEEGEV-EGEVEGEEGEGEGEEEEGEEEG 1043



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 58/214 (27%), Positives = 92/214 (42%), Gaps = 17/214 (7%)

Query: 162  GSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQESQGL 221
            G G+ EE E    D  G+        E   E  + EG E G   +GEE       E +G 
Sbjct: 930  GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGE-GEGEE------GEGEGE 982

Query: 222  LHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIE-QVNDEKGEQKQKQEQVQ 280
                E +  EE+G++E    GEG   E+   +G   EE  +E +V  E+GE + ++E+ +
Sbjct: 983  EEEGEGEGEEEEGEEEGEEEGEG--EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE 1040

Query: 281  DVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPEENRADS 340
            +     +GE     GE E       E+E+ E K Q  G  E   +   E +   + +   
Sbjct: 1041 E-----EGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSV 1095

Query: 341  QDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQ 374
            +  K +T+  KS  VT  Q +   +   +PV  +
Sbjct: 1096 KYGKHKTYQKKS--VTNTQGNGKEQRSKMPVQSK 1127


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 134/607 (22%), Positives = 193/607 (31%), Gaps = 98/607 (16%)

Query: 267  DEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEER 326
            D  GE+ +K+            E    T E E   + E E++D +  +  +   E  +E 
Sbjct: 1030 DSGGEEDEKESL---------SEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDED 1080

Query: 327  KRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGR 386
                +  E++  DS +E++ + +    E T   E     E            P S +   
Sbjct: 1081 TALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSE----FESSSESSPSSSEDEE 1136

Query: 387  LGAVGRARSREEENEHHGPSMPALIAPED----SPHCDLFPGASYLMTQIPGTQTESRAE 442
                      EEE E       A   PED         L PGA       P   +    E
Sbjct: 1137 EVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGA-------PAVDSLGMEE 1189

Query: 443  E--LSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGT 500
            E  +   A++P   P      P+ +          ++  D     EE  L +        
Sbjct: 1190 EVDIETEAVAPEERPSMLDEPPLPV--------GVEEPADSREPPEEPGLSQEGAMLLSP 1241

Query: 501  EVVFASASVTPPRTPDSAPPSPAEAYPITPASVSA--RPPVAFPRRETSCAARAPETASA 558
            E         PP +P+ AP    E  P  P  +    +PP+  PR       R P     
Sbjct: 1242 EPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPR-----PPRPPSPPPE 1296

Query: 559  PLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPD 618
            P + D   P    E         P     PP  P       +   +++ P +   E    
Sbjct: 1297 PETTDASHPSVPPE---------PLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLS 1347

Query: 619  LVGMLLSYSHSELPQRP-----PKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDS 673
                 LS S  ++P  P     P P++ S   PR     GRD+S    +PT         
Sbjct: 1348 GGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTP---GRDFSF---TPT--------- 1392

Query: 674  QESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRR 733
                     PS P  +     P         P   +SP  +    + +  PLP P P   
Sbjct: 1393 ------FSEPSGPLLLPVCPLPTGRRDERSGPL--ASPVLLET-GLPLPLPLPLPLPLAL 1443

Query: 734  DTHPSVVETDGHARVVVPTLKQH---SHPPPLALGSGLHAPHKGPLPQASDPAVARQHRP 790
               P+V+     A   +P L      S PPP+    G         P+ S P++     P
Sbjct: 1444 ---PAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGR--------PRRSPPSMLSLDGP 1492

Query: 791  LPSTPDSSHHAQATPRWRYNKP-LPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPT 849
            L   P  +    A  R     P  P TP  P  H P            P PP P+   P 
Sbjct: 1493 LVRPPAGA----ALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPP 1548

Query: 850  EPPPLPP 856
             PPP PP
Sbjct: 1549 PPPPPPP 1555



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 128/526 (24%), Positives = 181/526 (34%), Gaps = 126/526 (23%)

Query: 405 PSMPALIAP--EDSPHCDLFPGASYLMTQIPGTQTESRAEEL-----------------S 445
           P  P L  P  +DS +    P  SYL +Q P    ++R  E                  S
Sbjct: 274 PLTPRLGTPFSQDSSYSSRQPTPSYLFSQDPAVTFKARRHESKFTDAYNRRHEHHYVHNS 333

Query: 446 PA--ALSPSLEPIRCSHQ-PISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEV 502
           PA  A++ +    R S   P   +G       P  +      Q+ +        +Q T  
Sbjct: 334 PAVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFKAQP---QDSATFAHTPPPAQATPA 390

Query: 503 VFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSM 562
               ++ +P +TP +  P P E  P   A+  AR    F R      A  P   + PL+ 
Sbjct: 391 PGFKSAFSPYQTPVAHFPPPPEE-PTATAAFGARDSGEFRR----APAPPPLPPAEPLAK 445

Query: 563 DDPS------PCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGS------ 610
           + P       P  T+ M    L G P+ G SP   P +S GT     S + P        
Sbjct: 446 EKPGTPPGPPPPDTNSM---ELGGRPTFGWSPE--PCDSPGTPTLESSPAGPEKPHDSLD 500

Query: 611 ---------HRTE----QTPD------LVGMLLSYSHSELPQRPP-----KPAIYSSVTP 646
                     RT+    + PD      + G  +S S S+L    P     +P  +   TP
Sbjct: 501 SRIEMLLKEQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPG-FRGPTP 559

Query: 647 RRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPA 706
              R S      +S  PT L    +D +  +    RP   P       P +PA      A
Sbjct: 560 PSSRPSSTGLEDIS--PTPLPDSDEDEELDLGLGPRPPPEPG------PPDPAGLLSQTA 611

Query: 707 YGS-------SPSFVSM--------EDVRIHEP-LPPPPPQRRDTHPSVVETDGHARVVV 750
             +       +P+   M        ED+ I +  +P  P    D    +V T G A V  
Sbjct: 612 EVALDLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAA 671

Query: 751 PTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYN 810
           P++   + P P         P   PLP    P   +   P+P                  
Sbjct: 672 PSVLAPTLPLP-------PPPGFPPLPPPPPPPPPQPGFPMPP----------------- 707

Query: 811 KPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP 856
            PLPP P  P P  P ++ P       PLP  P + PP   PPLPP
Sbjct: 708 -PLPPPPPPPPPAHPAVTVPPP-----PLPAPPGVPPPPILPPLPP 747



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 166/752 (22%), Positives = 231/752 (30%), Gaps = 215/752 (28%)

Query: 138  PFSSDLGSEEEEVEFWPGLTSLTLGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNE 197
            P   D G EE+E E        T    +AEEEEE   D+   +      E    +T  +E
Sbjct: 1026 PLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSE 1085

Query: 198  GSESGTIRQGEELPPEELQESQGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLG 257
             SE     +G+    E +                E  + E+      +  ED        
Sbjct: 1086 ASEKD---EGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSED-------- 1134

Query: 258  EEQMIEQVNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQ 317
            EE+++ +   E+ E+++++E V +       E M   G  +   DGE         A   
Sbjct: 1135 EEEVVAR---EEEEEEEEEEMVAE-------ESMASAGPEDFEQDGEEAALAPGAPAVDS 1184

Query: 318  GGPEQGEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQ--EDHGIKEKGVPVSGQE 375
             G E+  + + E   PEE R    DE     +G  E    ++  E+ G+ ++G  +   E
Sbjct: 1185 LGMEEEVDIETEAVAPEE-RPSMLDEPPLP-VGVEEPADSREPPEEPGLSQEGAMLLSPE 1242

Query: 376  --AKEPESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIP 433
              AKE E                         + P L +PE +P  DL            
Sbjct: 1243 PPAKEVE-------------------------ARPPL-SPERAPEHDL------------ 1264

Query: 434  GTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEES----PDKEIDQNSQQEESR 489
              + E     + P  L P L P R    P        T+ S    P + + ++       
Sbjct: 1265 --EVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPG 1322

Query: 490  LRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCA 549
            L      SQ TE V        P TP   PP    +  ++ +S                 
Sbjct: 1323 LCGSLAKSQSTETV--------PATPGGEPPLSGGSSGLSLSS----------------- 1357

Query: 550  ARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPG 609
               P+   +P S   PSP  +S                 PR P          R  SF  
Sbjct: 1358 ---PQVPGSPFSYPAPSPSLSS--------------GGLPRTPG---------RDFSFTP 1391

Query: 610  SHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTL 669
            +      P L+ +             P P      T RRD RSG       ASP  L T 
Sbjct: 1392 TFSEPSGPLLLPVC------------PLP------TGRRDERSG-----PLASPVLLET- 1427

Query: 670  KQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPP-- 727
                      L  P   P   P   P                  V     R   PLPP  
Sbjct: 1428 ---------GLPLPLPLPLPLPLALP-----------------AVLRAQARAPTPLPPLL 1461

Query: 728  -------PPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQAS 780
                   PPP +R                 P   + S P  L+L   L  P  G      
Sbjct: 1462 PAPLASCPPPMKRK----------------PGRPRRSPPSMLSLDGPLVRPPAG------ 1499

Query: 781  DPAVARQHRPLPSTPDS----SHHAQATPRWRYNK---PLPPTPDLPQPHLPPISAPGSS 833
              A+ R+   LP  P +    S H   T    +     P PP P  PQP  PP   P   
Sbjct: 1500 -AALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPP--- 1555

Query: 834  RIYRPLPPLPIIDPPTEPPPLPPKSRGRSRST 865
             +     P   +D       +PP  RGR   T
Sbjct: 1556 -VEPTKLPFKELDNQWPSEAIPPGPRGRDEVT 1586



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 57/222 (25%), Positives = 82/222 (36%), Gaps = 39/222 (17%)

Query: 740  VETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGP------------LPQASDPAVARQ 787
            +ET+  A    P++      PPL +G    A  + P            L     PA   +
Sbjct: 1193 IETEAVAPEERPSMLDE---PPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVE 1249

Query: 788  HRPLPSTPDSS--HHAQATPRWRYNKPLP-----PTPDLPQPHLPPISAPGSSRIYRPLP 840
             RP P +P+ +  H  +  P      PLP     P P  P+P  PP     +   +  +P
Sbjct: 1250 ARP-PLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTDASHPSVP 1308

Query: 841  PLPIIDPPTEPPPLPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLP-ASAGRTSWP 899
            P P+ +      P    S  +S+ST           +T PA      PL   S+G +   
Sbjct: 1309 PEPLAEDHPPHTPGLCGSLAKSQST-----------ETVPATPGGEPPLSGGSSGLSLSS 1357

Query: 900  PATARSTESFTSTSRSKSE----VSPGMAFSNMTNFLCPSSP 937
            P    S  S+ + S S S      +PG  FS    F  PS P
Sbjct: 1358 PQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTFSEPSGP 1399


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 126/509 (24%), Positives = 178/509 (34%), Gaps = 60/509 (11%)

Query: 367 KGVPVSGQEAKEP-----ESWDGGRLGAVGRARSREEENEHHGPSMPALIAPEDSPHCDL 421
           KG  V+  + KEP     E+   G+ G     +     NE     MP L  PE+SP    
Sbjct: 397 KGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPLNEE----MPLLPPPEESP---- 448

Query: 422 FPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTEESPDKEIDQ 481
                  ++  P     S   E S   LSP  E +  S  P +L  S   EESP      
Sbjct: 449 -------LSPPPEESPTSPPPEAS--RLSPPPEELPASPLPEALHLSRPLEESP-----L 494

Query: 482 NSQQEESRLRKGTVSSQGTEVVFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAF 541
           +   EES L     SS      F+    +P   P+ +PPSPA   P++P   ++  P++ 
Sbjct: 495 SPPPEESPLSPPPESSP-----FSPLEESPLSPPEESPPSPALETPLSPPPEAS--PLSP 547

Query: 542 PRRETSCAARAPETASAPLSMDDPSPCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQH 601
           P  E+  +    E  ++P     P         P      P    SP  PP  ++     
Sbjct: 548 PFEESPLSPPPEELPTSP-----PPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPP 602

Query: 602 L-RSDSFPGSHRTEQTPDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVS 660
              S   P    +  +P      LS    + P  PP      S  P   R S     +  
Sbjct: 603 FEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRL 662

Query: 661 ASPTALSTLKQDSQESISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVR 720
           + P   S L    +ES      P+SPP     +SP  P  +  SP    SP+    ED  
Sbjct: 663 SPPPEESPLSPPPEES------PTSPPPEASRLSP-PPEDSPTSPPPEDSPASPPPEDSL 715

Query: 721 IHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLA--LGSGLHAPHKGPLPQ 778
           +  PL   P       P +        +     + H  P P    L      PH  P P+
Sbjct: 716 MSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPE 775

Query: 779 -------ASDPAVARQHR--PLPSTPDSSHHAQATPRWRYNKPLPPTPDL-PQPHLPPIS 828
                    +P ++ Q     L   P+  H +  T    +  P+P  P L PQP    +S
Sbjct: 776 EPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEE-PHLSPVPEEPCLSPQPEESHLS 834

Query: 829 APGSSRIYRPLPPLPIIDPPTEPPPLPPK 857
                    P P    + P  E PPL P+
Sbjct: 835 PQSEEPCLSPRPEESHLSPELEKPPLSPR 863



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 123/486 (25%), Positives = 163/486 (33%), Gaps = 91/486 (18%)

Query: 624  LSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERP 683
            LS    E P  PP  A   S  P     S    +   + P   S L    +ES  +    
Sbjct: 449  LSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPE 508

Query: 684  SSP-------PSIQPWVSPHNPAFATE-SPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDT 735
            SSP       P   P  SP +PA  T  SP   +SP     E+     PL PPP +   +
Sbjct: 509  SSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEE----SPLSPPPEELPTS 564

Query: 736  HPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTP 795
             P        +R+  P  +    PPP             P P+AS      +  PL   P
Sbjct: 565  PPPEA-----SRLSPPPEESPMSPPP-------EESPMSPPPEASRLFPPFEESPLSPPP 612

Query: 796  DSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLP 855
            + S  +      R + P   +P  P P   P+S P       PLP +  + PP E  PL 
Sbjct: 613  EESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLS 672

Query: 856  PKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRS 915
            P                       P  +  T P P  A R S PP      +S TS    
Sbjct: 673  P-----------------------PPEESPTSP-PPEASRLSPPP-----EDSPTSPPPE 703

Query: 916  KSEVSPGMAFSNMT-----NFLCPSSPTTPWTPELQGP---TSKDEAGVSEHPEAP---- 963
             S  SP    S M+     + L P        P  +GP      +E  +S  PE P    
Sbjct: 704  DSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSP 763

Query: 964  -AREPLRRTTPQQGA-----SGPGRSPVGQARQPE---KPSHLHLEKASSWPHRRDSGRP 1014
             A EP     P++         P  SP  QA  P    +P  LHL   +  PH       
Sbjct: 764  QAEEPHLSPQPEEPCLCAVPEEPHLSP--QAEGPHLSPQPEELHLSPQTEEPHLSPVPEE 821

Query: 1015 PGDSSGQAVAPSEGANKHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKK 1074
            P       ++P    +     S +    P + P        P +EK P     +  R +K
Sbjct: 822  P------CLSPQPEESHLSPQSEE----PCLSPRPEESHLSPELEKPP-----LSPRPEK 866

Query: 1075 PKEVMG 1080
            P E  G
Sbjct: 867  PPEEPG 872



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 130/567 (22%), Positives = 186/567 (32%), Gaps = 94/567 (16%)

Query: 505  ASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDD 564
            A   + PP      P SP E +   P  V A+ P   P          P   +AP +   
Sbjct: 2139 ADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPP 2198

Query: 565  -PSPCGTSEMCPA-ALYGFPSTG------TSPPRPPANSTGTVQHLRSDSFPGSHRTEQT 616
             PSP G     P       P  G      T+PP  P +   T         P        
Sbjct: 2199 YPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLA-V 2257

Query: 617  PDLVGMLLSYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQES 676
            P+  G+    +   L   PP      ++  +++       S+ S  P  L  +   S  +
Sbjct: 2258 PESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGA---SSPSYGPPNLGFVDSPSSGT 2314

Query: 677  ISNLERPSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTH 736
                    +P   +  ++P       +SP  G  P     ++    + L P PP   D  
Sbjct: 2315 HLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRP-----QEPPPAQALAPSPPSHPDIF 2369

Query: 737  PSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPD 796
                 TD +A+   P L     PPP      L      P    SDP        +P++P 
Sbjct: 2370 RPGSYTDPYAQ---PPLTPRPQPPPPESCCALP-----PRSLPSDP-----FSRVPASPQ 2416

Query: 797  SSHHAQA--TPRWRYNKPLPPTPDLPQPHLP-PISAPGSSRIYRPLPPLPIIDPPTEPPP 853
            S   +Q+  TPR    +   P+P  P+   P P S P S    R  P  P+  PP    P
Sbjct: 2417 SQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRD-PFAPLHKPPR---P 2472

Query: 854  LPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARS--TESFTS 911
             PP+   ++ S     + +GG     PA     +     +G+   PP   RS  T +F  
Sbjct: 2473 QPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQ---PPNFVRSPGTGAFVG 2529

Query: 912  TSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRT 971
            T       SP M F+                                 P+A     L+  
Sbjct: 2530 TP------SP-MRFT--------------------------------FPQAVGEPSLKPP 2550

Query: 972  TPQQGASGPG--RSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVAPSEGA 1029
             PQ G   P    S  G      KP   +   A+   H   SG P G SSG         
Sbjct: 2551 VPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFH--PSGSPLGPSSG--------- 2599

Query: 1030 NKHKGWSRQGLRRPSILPEGSSDSRGP 1056
            +  + +    LR PS+LP  + D   P
Sbjct: 2600 STGESYGLSPLRPPSVLPPPAPDGSLP 2626



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 147/617 (23%), Positives = 199/617 (32%), Gaps = 135/617 (21%)

Query: 413  PEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALSPSLEPIRCSHQPISLLGSFLTE 472
            PE+SP     P AS L      +      EE   + LSP  E  R S  P     S   E
Sbjct: 585  PEESPMSPP-PEASRLFPPFEESPLSPPPEE---SPLSPPPEASRLSPPPEDSPMSPPPE 640

Query: 473  ESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASASVTPPR-TPDSAPPSPAEAYPITPA 531
            ESP      +   E SRL    V S+ +     S    PP  +P S PP  +   P    
Sbjct: 641  ESP-----MSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPED 695

Query: 532  SVSARPPVAFPRRETSCAARAPETASAPLSMDD----PSPCGTSEMCPAALYGFPSTGTS 587
            S ++ PP      E S A+  PE +   L +++    P P    ++CP +    P     
Sbjct: 696  SPTSPPP------EDSPASPPPEDSLMSLPLEESPLLPLP-EEPQLCPRS--EGPHLSPR 746

Query: 588  PPRPPANSTGTVQHLRSDSFPGSHRTEQ---------------TPDLVGMLLSYSHSELP 632
            P  P  +      HL S      H + Q               +P   G  LS    EL 
Sbjct: 747  PEEPHLSPRPEEPHL-SPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELH 805

Query: 633  QRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLERPSSPPSIQPW 692
              P     + S  P     S +   +  +  +    L    +ES  + E    P S +P 
Sbjct: 806  LSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPE 865

Query: 693  VSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPT 752
              P  P    + PA    P F              PPP      P + E         P 
Sbjct: 866  KPPEEPG---QCPAPEELPLF--------------PPPGEPSLSPLLGE---------PA 899

Query: 753  LKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRP---LPSTPDSSHHAQATPRWRY 809
            L +   PP   L      P + PL  + +P+++ Q  P   LP        A A P    
Sbjct: 900  LSEPGEPPLSPL------PEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPA--- 950

Query: 810  NKPLPPTPDLPQPH--------LPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPPKSRGR 861
               L P  +L  P           P++AP       P P     DP   PP + P S G 
Sbjct: 951  ---LSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPG- 1006

Query: 862  SRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSRSKSEVSP 921
                          +   PA      PLP        P  +     S    +   S+ SP
Sbjct: 1007 --------------SPVGPASPILMEPLP--------PQCSPLLQHSLVPQNSPPSQCSP 1044

Query: 922  GMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSE-------HPEAPAREPLRRTTPQ 974
                        P S  +P +P  +     DEA + E        PE PA EP       
Sbjct: 1045 P---------ALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEP------- 1088

Query: 975  QGASGPGRSPVGQARQP 991
              A+ P  SP+G    P
Sbjct: 1089 -SATSPLPSPMGDLSCP 1104



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 124/589 (21%), Positives = 186/589 (31%), Gaps = 124/589 (21%)

Query: 503  VFASASVTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSM 562
            +F   S T P    + PP      P  P S  A PP + P    S    +P++ S+  S 
Sbjct: 2368 IFRPGSYTDPY---AQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSP 2424

Query: 563  DDPSPCGTSEMCPAAL---YGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHR--TEQTP 617
              P P      CP+ +   +  P   + PP  P +          D F   H+    Q P
Sbjct: 2425 LTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQS---------RDPFAPLHKPPRPQPP 2475

Query: 618  DLVGMLLSYSHSEL------PQRPPKPA------IYSSVTPRRDRRSGRDYSTVSASPTA 665
            ++     S +H+ L         P  PA      + S   P   R  G      + SP  
Sbjct: 2476 EVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMR 2535

Query: 666  LSTLKQDSQESIS-NLERPSSPP---------------------------SIQPWVSPHN 697
             +  +   + S+   + +P  PP                           +  P  SP  
Sbjct: 2536 FTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLG 2595

Query: 698  PAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHS 757
            P+  +   +YG SP       +R    LPPP P   D     +      R  + +  +  
Sbjct: 2596 PSSGSTGESYGLSP-------LRPPSVLPPPAP---DGSLPYLSHGASQRSGITSPVEKR 2645

Query: 758  HPPPLALGSGLHAPHKGPLPQASDPAVA----------RQHRPL---------------- 791
              P   +GS L       LP   DP ++          RQ + L                
Sbjct: 2646 EDPGTGMGSSLAT---AELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQ 2702

Query: 792  -PSTPDSSHHAQATP-RWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPL----PII 845
               T  ++  A   P  W      P    L +   P       S +   LPP     PI+
Sbjct: 2703 EKETAAAAAGAVGPPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLV-GLPPSKLSGPIL 2761

Query: 846  DPPTEPPP-----LPPKSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRT-SWP 899
             P + P        PP +   S       +  G  A  + A    ++PL     +     
Sbjct: 2762 GPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQ 2821

Query: 900  PATARSTESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEH 959
             ATA ++  F  ++R  S   P +    +       SP    +  L GP           
Sbjct: 2822 QATAATSMRFAMSARFPSTPGPELGRQAL------GSPLAGISTRLPGPGEPVPG----- 2870

Query: 960  PEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHR 1008
            P  PA+    R   Q+G  GPG +P      P++P        S  PHR
Sbjct: 2871 PAGPAQFIELRHNVQKGL-GPGGTPFPGQGPPQRP---RFYPVSEDPHR 2915



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 71/323 (21%), Positives = 103/323 (31%), Gaps = 35/323 (10%)

Query: 726  PPPPPQRRDTHPSV--VETDGHARVVVPTLKQHSHPPPLAL--------GSGLHAPHKGP 775
            PP P       P    V   G  +    T  Q   P PL          G  L    + P
Sbjct: 374  PPEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAP 433

Query: 776  LPQASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRI 835
            L +        +  PL   P+ S  +      R + P    P  P P    +S P     
Sbjct: 434  LNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESP 493

Query: 836  YRPLPPLPIIDPPTEPPPL---------PPKSRGRSRSTRGGHMNSGGHAKTRPACQDWT 886
              P P    + PP E  P          PP+    S +           +   P  ++  
Sbjct: 494  LSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESP 553

Query: 887  VPLPASAGRTSWPPATARST----ESFTSTSRSKSEVSPGMAFSNMTNFLCPSSPTTPWT 942
            +  P     TS PP  +R +    ES  S    +S +SP    S     L P    +P +
Sbjct: 554  LSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASR----LFPPFEESPLS 609

Query: 943  PELQGPTSKDEAGVSEHPEAPAREPLRRTTPQQGASGPGRSPVGQARQPEKPSHLHLEKA 1002
            P        +E+ +S  PEA    P    +P   +  P  SP+    +  + S L +   
Sbjct: 610  P------PPEESPLSPPPEASRLSPPPEDSPM--SPPPEESPMSPPPEVSRLSPLPVVSR 661

Query: 1003 SSWPHRRDSGRPPGDSSGQAVAP 1025
             S P       PP + S  +  P
Sbjct: 662  LSPPPEESPLSPPPEESPTSPPP 684



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 55/266 (20%), Positives = 111/266 (41%), Gaps = 46/266 (17%)

Query: 203  TIRQGEELPPEELQESQ-GLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQM 261
            T +Q ++    + Q S  GL H Q+  ++   GQ +   +  G+L++       L ++Q 
Sbjct: 3854 TAQQQQQQQQHQQQGSMAGLSHLQQ-SLMSHSGQPKLSAQPMGSLQQ-------LQQQQQ 3905

Query: 262  IEQ---VNDEKGEQKQKQEQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQG 318
            ++Q   +  ++ +Q Q+Q+Q+Q   L +Q ++  L  + +     + +Q   +++ Q Q 
Sbjct: 3906 LQQQQQLQQQQQQQLQQQQQLQQQQLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQ 3965

Query: 319  GPEQGEERK-------RELQVPEENRADS------------QDEKSQTFLGKSEEVTGKQ 359
              +Q ++++       R L  P++ +               Q   S   LG +  +TGK+
Sbjct: 3966 FQQQQQQQQMGLLNQSRTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKE 4025

Query: 360  EDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGRARSREEENEHHGPSMPA-----LIAPE 414
            ++         VS +  + P +  GG L       S   E     PS+       L+ P+
Sbjct: 4026 QN----TVDPAVSSEATEGPSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQ 4081

Query: 415  DSPHCDLFPGASYLM--TQIPGTQTE 438
              P     P +  L    ++PG Q +
Sbjct: 4082 PQPQ----PSSLQLQPPLRLPGQQQQ 4103



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 43/175 (24%), Positives = 59/175 (33%), Gaps = 42/175 (24%)

Query: 714  VSMEDVRIHEPLPPPPPQRRDTHPSVVETDGHARVVVPTLKQHSHPPPLALGSGLHAPHK 773
            +SM+    +E L P  P R  T P   E +G              P     G    +P  
Sbjct: 4807 LSMKIPNSYEVLFPESPARAGTEPKKGEAEG--------------PGGKEKGLEGKSPDT 4852

Query: 774  GP---------LP------QASDPAVARQHRPLPSTPDSSHHAQATPRWRYNKPLPPTPD 818
            GP         LP      Q    ++ +Q  P P  P    +          +   P P+
Sbjct: 4853 GPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPE 4912

Query: 819  LPQPHLPPISAPGSSRIYRP---LPPLPIIDPPTEPPPLP---------PKSRGR 861
             P P   P++   +S    P   LP  P+ +PP  P PLP         PK R R
Sbjct: 4913 EPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPV-PSPLPLASSPESARPKPRAR 4966



 Score = 31.6 bits (70), Expect = 6.4
 Identities = 39/177 (22%), Positives = 66/177 (37%), Gaps = 50/177 (28%)

Query: 226  EVQVLEEQGQQE----AGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQEQV-- 279
            + +VL   GQ +    A    EG + + +      G+E+  +Q    +G +K K E +  
Sbjct: 1717 QAEVLSGDGQPDEVIPADLPAEGAVEQSLAE----GDEKKKQQ---RRGRKKSKLEDMFP 1769

Query: 280  ---QDVMLGRQ--------------GERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQ 322
               Q+   G++              G      G P+   DG  E++++    +G  GP+ 
Sbjct: 1770 AYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDI 1829

Query: 323  GEERKRELQVPEENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEP 379
             +E  R L    E +AD                T   ED G+K   VP   ++   P
Sbjct: 1830 ADEESRGL----EGKAD----------------TPGPEDGGVKASPVPSDPEKPGTP 1866


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
            sapiens]
          Length = 927

 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 74/295 (25%), Positives = 135/295 (45%), Gaps = 26/295 (8%)

Query: 1165 LLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTSLRATLSNQEHQWLFSRLQD 1224
            L S+     K QEV  EL+V+EA+++R L +  D F    +       +E Q +F  L +
Sbjct: 422  LHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDE 481

Query: 1225 VRDVSATFLSDL-EENFENNIFSFQVCDVVLNHAPD-----FRRVYLPYVTNQTYQERTF 1278
            + +V + FL  L +   E+     ++ DV+L          F+++   + + Q++     
Sbjct: 482  LIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 541

Query: 1279 QSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEE 1338
            ++    +  F   +++ ES P C+RL LK  +    QR+T+  LLLQ+I + T+  +  E
Sbjct: 542  KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTERE 601

Query: 1339 AEATKAH------HALEQLIRDCNN--NVQSMRRTEELIYLSQKIEFECKIFPLISQSRW 1390
                 A       H + Q +RD  +   ++  +R  +L +L Q  +      P++S+   
Sbjct: 602  KVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSD------PMLSE--- 652

Query: 1391 LVKSGELTALEF-SASPGLRRKLNTRPVHLH-LFNDCLLLSRPREGSRFLVFDHA 1443
              K+ ++T  +     P   R    + V +H L  D LLL   R+  R L+  H+
Sbjct: 653  -FKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHS 706


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,154,265
Number of Sequences: 37866
Number of extensions: 4494683
Number of successful extensions: 32822
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 1679
Number of HSP's that attempted gapping in prelim test: 19411
Number of HSP's gapped (non-prelim): 9611
length of query: 1597
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1481
effective length of database: 13,855,062
effective search space: 20519346822
effective search space used: 20519346822
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.