Guide to the Human Genome
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Name: SGEF Sequence: fasta or formatted (871aa) NCBI GI: 194473700
Description:

Src homology 3 domain-containing guanine nucleotide exchange factor

Referenced in:

Rho and Rac

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.4         47           2
 C cysteine            1.1         10           1
 D aspartate           4.5         39           2
 E glutamate           7.9         69           2
 F phenylalanine       2.9         25           2
 G glycine             5.1         44           2
 H histidine           1.7         15           2
 I isoleucine          4.0         35           2
 K lysine              7.3         64           3
 L leucine             9.8         85           3
 M methionine          2.0         17           2
 N asparagine          4.2         37           2
 P proline             7.2         63           5
 Q glutamine           4.6         40           2
 R arginine            6.8         59           3
 S serine             11.0         96           3
 T threonine           5.4         47           1
 V valine              6.3         55           2
 W tryptophan          0.7          6           1
 Y tyrosine            2.1         18           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   Src homology 3 domain-containing guanine nucleotide... 
ARHGEF16              0.286   Rho guanine exchange factor 16 
NGEF                  0.172   neuronal guanine nucleotide exchange factor isoform...
NGEF                  0.172   neuronal guanine nucleotide exchange factor isoform...
ARHGEF5               0.155   rho guanine nucleotide exchange factor 5 
ARHGEF19              0.142   Rho guanine nucleotide exchange factor (GEF) 19 [Hom...
ARHGEF15              0.128   Rho guanine exchange factor 15 
ITSN1                 0.053   intersectin 1 isoform ITSN-l 
ITSN2                 0.051   intersectin 2 isoform 3 
ITSN2                 0.051   intersectin 2 isoform 1 
PLEKHG5               0.044   pleckstrin homology domain containing family G membe...
PLEKHG5               0.044   pleckstrin homology domain containing family G memb...
PLEKHG5               0.044   pleckstrin homology domain containing family G memb...
PLEKHG5               0.044   pleckstrin homology domain containing family G memb...
PLEKHG5               0.044   pleckstrin homology domain containing family G memb...
FGD4                  0.036   FYVE, RhoGEF and PH domain containing 4 
FGD2                  0.036   FYVE, RhoGEF and PH domain containing 2 
ARHGEF12              0.035   Rho guanine nucleotide exchange factor (GEF) 12 [Homo...
NET1                  0.034   neuroepithelial cell transforming gene 1 isoform 1 ...
NET1                  0.032   neuroepithelial cell transforming gene 1 isoform 2 [...
ARHGEF11              0.032   Rho guanine nucleotide exchange factor (GEF) 11 isof...
ARHGEF11              0.032   Rho guanine nucleotide exchange factor (GEF) 11 isofo...
FGD1                  0.032   faciogenital dysplasia protein 
ARHGEF4               0.031   Rho guanine nucleotide exchange factor 4 isoform b [...
ECT2                  0.029   epithelial cell transforming sequence 2 oncogene pro...
ARHGEF4               0.029   Rho guanine nucleotide exchange factor 4 isoform a [...
PREX1                 0.029   phosphatidylinositol-3,4,5-trisphosphate-dependent R...
PLEKHG6               0.029   pleckstrin homology domain-containing family G memb...
PLEKHG6               0.029   pleckstrin homology domain-containing family G memb...
PLEKHG6               0.029   pleckstrin homology domain-containing family G memb...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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