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Search of human proteins with 50843837
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
(1519 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 3071 0.0
gi|193211598 pleckstrin homology domain containing, family G (wi... 400 e-111
gi|193211596 pleckstrin homology domain containing, family G (wi... 400 e-111
gi|193211594 pleckstrin homology domain containing, family G (wi... 400 e-111
gi|55742734 pleckstrin homology domain containing, family G (wit... 400 e-111
gi|193211603 pleckstrin homology domain containing, family G (wi... 383 e-106
gi|148529025 pleckstrin homology domain containing, family G (wi... 378 e-104
gi|71274186 hypothetical protein LOC85449 [Homo sapiens] 260 8e-69
gi|163644325 MCF.2 cell line derived transforming sequence-like ... 121 4e-27
gi|163644323 MCF.2 cell line derived transforming sequence-like ... 121 4e-27
gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapi... 114 7e-25
gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapi... 113 2e-24
gi|153791628 MCF.2 cell line derived transforming sequence isofo... 105 4e-22
gi|153791325 MCF.2 cell line derived transforming sequence isofo... 105 4e-22
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 102 3e-21
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens] 102 3e-21
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 102 4e-21
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 99 2e-20
gi|31742505 Rho family guanine-nucleotide exchange factor [Homo ... 80 2e-14
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 79 3e-14
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 79 3e-14
gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho... 71 9e-12
gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho... 71 9e-12
gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho... 71 9e-12
gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens] 66 2e-10
gi|48762934 alpha 2 type I collagen [Homo sapiens] 66 3e-10
gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein ... 65 4e-10
gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein ... 65 4e-10
gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein ... 65 4e-10
gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo s... 65 4e-10
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 3071 bits (7962), Expect = 0.0
Identities = 1519/1519 (100%), Positives = 1519/1519 (100%)
Query: 1 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 60
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA
Sbjct: 1 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 60
Query: 61 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 120
KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA
Sbjct: 61 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 120
Query: 121 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 180
LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE
Sbjct: 121 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 180
Query: 181 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 240
LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG
Sbjct: 181 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG 240
Query: 241 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 300
EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ
Sbjct: 241 EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ 300
Query: 301 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 360
DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG
Sbjct: 301 DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 360
Query: 361 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 420
GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP
Sbjct: 361 GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 420
Query: 421 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 480
SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL
Sbjct: 421 SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL 480
Query: 481 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 540
CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG
Sbjct: 481 CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG 540
Query: 541 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 600
GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL
Sbjct: 541 GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL 600
Query: 601 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 660
PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW
Sbjct: 601 PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW 660
Query: 661 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 720
ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ
Sbjct: 661 ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ 720
Query: 721 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 780
KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ
Sbjct: 721 KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ 780
Query: 781 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 840
EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE
Sbjct: 781 EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE 840
Query: 841 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE 900
ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE
Sbjct: 841 ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE 900
Query: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA
Sbjct: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
Query: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG
Sbjct: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
Query: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK 1080
PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK
Sbjct: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK 1080
Query: 1081 RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH 1140
RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH
Sbjct: 1081 RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH 1140
Query: 1141 FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL 1200
FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL
Sbjct: 1141 FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL 1200
Query: 1201 PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR 1260
PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR
Sbjct: 1201 PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR 1260
Query: 1261 GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK 1320
GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
Sbjct: 1261 GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK 1320
Query: 1321 TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE 1380
TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE
Sbjct: 1321 TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE 1380
Query: 1381 LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG 1440
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG
Sbjct: 1381 LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG 1440
Query: 1441 ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI 1500
ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI
Sbjct: 1441 ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI 1500
Query: 1501 LGLSRQSHARALSDPTTPL 1519
LGLSRQSHARALSDPTTPL
Sbjct: 1501 LGLSRQSHARALSDPTTPL 1519
>gi|193211598 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 400 bits (1028), Expect = e-111
Identities = 344/1051 (32%), Positives = 497/1051 (47%), Gaps = 136/1051 (12%)
Query: 470 GERELEGPGLLCMAGHTGPEGPLSDTPTP-PLETVQEGKGDNIPEEA----LAVSVSDHP 524
GE + G GL+ G GP + +P L++ G GD + E + A S S P
Sbjct: 118 GESDTPGVGLV---GDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLP 174
Query: 525 ---------DVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHY 574
D+ W+L+ASG L G D GRA+L + P + S L L Y
Sbjct: 175 KPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLY 234
Query: 575 LHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLP 632
L S+ RP++Q LGL+VL+D R P +L LSQLQ++ + Q LL+ + ++P
Sbjct: 235 LRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVP 293
Query: 633 TELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLG 692
+ G Q ++ S++ L + L LGG W++ + + L + CQ
Sbjct: 294 S---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 693 SVRQAIEELEGAAEPEEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS--- 744
++ AIE ++ +P E VG +Q+VL P L LQ GG L L+
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVP 409
Query: 745 ----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWL 796
+P + LY VD +HQL SN +Q E Q L L Q+ WL
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWL 469
Query: 797 SGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENAT 849
G L P +L L + + F+ QE++ Q + L A E +
Sbjct: 470 QQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPP 527
Query: 850 SQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGRE 900
+ L + F + L Q L A RL + F++A W +EG A L PG
Sbjct: 528 GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVV 587
Query: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
L R P+ F++M ALA LGS A +E ARCQ+ + Q + EA
Sbjct: 588 LQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EA 645
Query: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
S + P S +SL + P AP+H L G
Sbjct: 646 SLK-------------------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLG 683
Query: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------V 1072
L+ A C + R P+ G V
Sbjct: 684 QSLSEPA------------------------CHCHHAATIAACRRPEAGGGALPQASPTV 719
Query: 1073 GTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAAL 1127
P RS++ Q +++E++A E++YV L + PEL P+ LRG A
Sbjct: 720 PPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLF 779
Query: 1128 SARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS 1187
E+LR FH FLREL+ C HP R+ FLRH QF +YA Y K++ + + +++
Sbjct: 780 GNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYG 839
Query: 1188 -PLSKGSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLL 1243
K +A G +L A L +P++++ +Y LL+EL R G + E AL A L+
Sbjct: 840 HTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLV 898
Query: 1244 REQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKL 1303
Q G DLLA++A++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK
Sbjct: 899 HFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1304 KGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKW 1363
+ G + F YK++FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK W
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAW 1018
Query: 1364 TSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTR 1419
T+ I+ LLWRQA HNKE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+R
Sbjct: 1019 TADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSR 1078
Query: 1420 ASVAVSSFEH------AGPSLPGLSPGACSL 1444
AS+AV+ F+H A SLPG P +CS+
Sbjct: 1079 ASIAVAPFDHDSLYLGASNSLPG-DPASCSV 1108
>gi|193211596 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 400 bits (1028), Expect = e-111
Identities = 344/1051 (32%), Positives = 497/1051 (47%), Gaps = 136/1051 (12%)
Query: 470 GERELEGPGLLCMAGHTGPEGPLSDTPTP-PLETVQEGKGDNIPEEA----LAVSVSDHP 524
GE + G GL+ G GP + +P L++ G GD + E + A S S P
Sbjct: 118 GESDTPGVGLV---GDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLP 174
Query: 525 ---------DVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHY 574
D+ W+L+ASG L G D GRA+L + P + S L L Y
Sbjct: 175 KPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLY 234
Query: 575 LHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLP 632
L S+ RP++Q LGL+VL+D R P +L LSQLQ++ + Q LL+ + ++P
Sbjct: 235 LRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVP 293
Query: 633 TELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLG 692
+ G Q ++ S++ L + L LGG W++ + + L + CQ
Sbjct: 294 S---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 693 SVRQAIEELEGAAEPEEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS--- 744
++ AIE ++ +P E VG +Q+VL P L LQ GG L L+
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVP 409
Query: 745 ----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWL 796
+P + LY VD +HQL SN +Q E Q L L Q+ WL
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWL 469
Query: 797 SGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENAT 849
G L P +L L + + F+ QE++ Q + L A E +
Sbjct: 470 QQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPP 527
Query: 850 SQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGRE 900
+ L + F + L Q L A RL + F++A W +EG A L PG
Sbjct: 528 GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVV 587
Query: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
L R P+ F++M ALA LGS A +E ARCQ+ + Q + EA
Sbjct: 588 LQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EA 645
Query: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
S + P S +SL + P AP+H L G
Sbjct: 646 SLK-------------------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLG 683
Query: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------V 1072
L+ A C + R P+ G V
Sbjct: 684 QSLSEPA------------------------CHCHHAATIAACRRPEAGGGALPQASPTV 719
Query: 1073 GTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAAL 1127
P RS++ Q +++E++A E++YV L + PEL P+ LRG A
Sbjct: 720 PPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLF 779
Query: 1128 SARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS 1187
E+LR FH FLREL+ C HP R+ FLRH QF +YA Y K++ + + +++
Sbjct: 780 GNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYG 839
Query: 1188 -PLSKGSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLL 1243
K +A G +L A L +P++++ +Y LL+EL R G + E AL A L+
Sbjct: 840 HTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLV 898
Query: 1244 REQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKL 1303
Q G DLLA++A++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK
Sbjct: 899 HFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1304 KGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKW 1363
+ G + F YK++FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK W
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAW 1018
Query: 1364 TSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTR 1419
T+ I+ LLWRQA HNKE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+R
Sbjct: 1019 TADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSR 1078
Query: 1420 ASVAVSSFEH------AGPSLPGLSPGACSL 1444
AS+AV+ F+H A SLPG P +CS+
Sbjct: 1079 ASIAVAPFDHDSLYLGASNSLPG-DPASCSV 1108
>gi|193211594 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 400 bits (1028), Expect = e-111
Identities = 344/1051 (32%), Positives = 497/1051 (47%), Gaps = 136/1051 (12%)
Query: 470 GERELEGPGLLCMAGHTGPEGPLSDTPTP-PLETVQEGKGDNIPEEA----LAVSVSDHP 524
GE + G GL+ G GP + +P L++ G GD + E + A S S P
Sbjct: 118 GESDTPGVGLV---GDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLP 174
Query: 525 ---------DVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHY 574
D+ W+L+ASG L G D GRA+L + P + S L L Y
Sbjct: 175 KPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLY 234
Query: 575 LHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLP 632
L S+ RP++Q LGL+VL+D R P +L LSQLQ++ + Q LL+ + ++P
Sbjct: 235 LRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVP 293
Query: 633 TELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLG 692
+ G Q ++ S++ L + L LGG W++ + + L + CQ
Sbjct: 294 S---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 693 SVRQAIEELEGAAEPEEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS--- 744
++ AIE ++ +P E VG +Q+VL P L LQ GG L L+
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVP 409
Query: 745 ----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWL 796
+P + LY VD +HQL SN +Q E Q L L Q+ WL
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWL 469
Query: 797 SGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENAT 849
G L P +L L + + F+ QE++ Q + L A E +
Sbjct: 470 QQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPP 527
Query: 850 SQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGRE 900
+ L + F + L Q L A RL + F++A W +EG A L PG
Sbjct: 528 GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVV 587
Query: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
L R P+ F++M ALA LGS A +E ARCQ+ + Q + EA
Sbjct: 588 LQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EA 645
Query: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
S + P S +SL + P AP+H L G
Sbjct: 646 SLK-------------------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLG 683
Query: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------V 1072
L+ A C + R P+ G V
Sbjct: 684 QSLSEPA------------------------CHCHHAATIAACRRPEAGGGALPQASPTV 719
Query: 1073 GTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAAL 1127
P RS++ Q +++E++A E++YV L + PEL P+ LRG A
Sbjct: 720 PPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLF 779
Query: 1128 SARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS 1187
E+LR FH FLREL+ C HP R+ FLRH QF +YA Y K++ + + +++
Sbjct: 780 GNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYG 839
Query: 1188 -PLSKGSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLL 1243
K +A G +L A L +P++++ +Y LL+EL R G + E AL A L+
Sbjct: 840 HTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLV 898
Query: 1244 REQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKL 1303
Q G DLLA++A++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK
Sbjct: 899 HFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1304 KGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKW 1363
+ G + F YK++FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK W
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAW 1018
Query: 1364 TSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTR 1419
T+ I+ LLWRQA HNKE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+R
Sbjct: 1019 TADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSR 1078
Query: 1420 ASVAVSSFEH------AGPSLPGLSPGACSL 1444
AS+AV+ F+H A SLPG P +CS+
Sbjct: 1079 ASIAVAPFDHDSLYLGASNSLPG-DPASCSV 1108
>gi|55742734 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 1 [Homo sapiens]
Length = 1191
Score = 400 bits (1028), Expect = e-111
Identities = 344/1051 (32%), Positives = 497/1051 (47%), Gaps = 136/1051 (12%)
Query: 470 GERELEGPGLLCMAGHTGPEGPLSDTPTP-PLETVQEGKGDNIPEEA----LAVSVSDHP 524
GE + G GL+ G GP + +P L++ G GD + E + A S S P
Sbjct: 118 GESDTPGVGLV---GDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLP 174
Query: 525 ---------DVAWDLMASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHY 574
D+ W+L+ASG L G D GRA+L + P + S L L Y
Sbjct: 175 KPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLY 234
Query: 575 LHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLP 632
L S+ RP++Q LGL+VL+D R P +L LSQLQ++ + Q LL+ + ++P
Sbjct: 235 LRSIPRPEVQALGLTVLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVP 293
Query: 633 TELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLG 692
+ G Q ++ S++ L + L LGG W++ + + L + CQ
Sbjct: 294 S---GLQLEQLPSQSLLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACA 349
Query: 693 SVRQAIEELEGAAEPEEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS--- 744
++ AIE ++ +P E VG +Q+VL P L LQ GG L L+
Sbjct: 350 LLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVP 409
Query: 745 ----TPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWL 796
+P + LY VD +HQL SN +Q E Q L L Q+ WL
Sbjct: 410 EVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWL 469
Query: 797 SGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENAT 849
G L P +L L + + F+ QE++ Q + L A E +
Sbjct: 470 QQVGWPALEEAGEP--SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPP 527
Query: 850 SQKVLDI------FEQRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGRE 900
+ L + F + L Q L A RL + F++A W +EG A L PG
Sbjct: 528 GARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVV 587
Query: 901 AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA 960
L R P+ F++M ALA LGS A +E ARCQ+ + Q + EA
Sbjct: 588 LQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EA 645
Query: 961 SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG 1020
S + P S +SL + P AP+H L G
Sbjct: 646 SLK-------------------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLG 683
Query: 1021 PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------V 1072
L+ A C + R P+ G V
Sbjct: 684 QSLSEPA------------------------CHCHHAATIAACRRPEAGGGALPQASPTV 719
Query: 1073 GTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAAL 1127
P RS++ Q +++E++A E++YV L + PEL P+ LRG A
Sbjct: 720 PPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLF 779
Query: 1128 SARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS 1187
E+LR FH FLREL+ C HP R+ FLRH QF +YA Y K++ + + +++
Sbjct: 780 GNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYG 839
Query: 1188 -PLSKGSMEA-GPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLL 1243
K +A G +L A L +P++++ +Y LL+EL R G + E AL A L+
Sbjct: 840 HTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLV 898
Query: 1244 REQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKL 1303
Q G DLLA++A++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK
Sbjct: 899 HFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKP 958
Query: 1304 KGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKW 1363
+ G + F YK++FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK W
Sbjct: 959 RHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAW 1018
Query: 1364 TSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTR 1419
T+ I+ LLWRQA HNKE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+R
Sbjct: 1019 TADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSR 1078
Query: 1420 ASVAVSSFEH------AGPSLPGLSPGACSL 1444
AS+AV+ F+H A SLPG P +CS+
Sbjct: 1079 ASIAVAPFDHDSLYLGASNSLPG-DPASCSV 1108
>gi|193211603 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4 isoform 2 [Homo sapiens]
Length = 1110
Score = 383 bits (984), Expect = e-106
Identities = 321/976 (32%), Positives = 465/976 (47%), Gaps = 119/976 (12%)
Query: 531 MASGFLILTGGVDQSGRALLTITPPCPPE-EPPPSRDTLNTTLHYLHSLLRPDLQTLGLS 589
M+S + G D GRA+L + P + S L L YL S+ RP++Q LGL+
Sbjct: 109 MSSHLSLAQGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLT 168
Query: 590 VLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLI--LIHDDLPTELCGFQGAEVLSEN 647
VL+D R P +L LSQLQ++ + Q LL+ + ++P+ G Q ++ S++
Sbjct: 169 VLVDARICAP-SSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPS---GLQLEQLPSQS 224
Query: 648 DLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEP 707
L + L LGG W++ + + L + CQ ++ AIE ++ +P
Sbjct: 225 LLTHIPTAG-LPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQP 283
Query: 708 EEEEAVGMPKP-----LQKVLADPRLTALQRDGGAILMRLRS-------TPSSKLEGQGP 755
E VG +Q+VL P L LQ GG L L+ +P +
Sbjct: 284 MEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKA 343
Query: 756 ATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRR----LQQVLQWLSGPGEEQLASFAMPG 811
LY VD +HQL SN +Q E Q L L Q+ WL G L P
Sbjct: 344 DELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEP- 402
Query: 812 DTLSALQETELRFRAFSAEVQERLAQAREAL-------ALEENATSQKVLDI------FE 858
+L L + + F+ QE++ Q + L A E + + L + F
Sbjct: 403 -SLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFS 461
Query: 859 QRLEQVESGLHRALRLQRFFQQAHEWVDEG---FARLAGAGPGREAVLAALALRRAPEPS 915
+ L Q L A RL + F++A W +EG A L PG L R P+
Sbjct: 462 RALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLP 521
Query: 916 AGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADGASS 975
F++M ALA LGS A +E ARCQ+ + Q + EAS +
Sbjct: 522 PAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKL--EASLK------------ 567
Query: 976 GGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGRPPRAV 1035
P S +SL + P AP+H L G L+ A
Sbjct: 568 -------LPPVGSTASLCVSQVPA---APAHPPLRKAYSFDRNLGQSLSEPA-------- 609
Query: 1036 LIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWG--------VGTPRMERKRSISAQQ 1087
C + R P+ G V P RS++ Q
Sbjct: 610 ----------------CHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQ 653
Query: 1088 RLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRGTWAAALSARERLRSFHRTHFL 1142
+++E++A E++YV L + PEL P+ LRG A E+LR FH FL
Sbjct: 654 LVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFL 713
Query: 1143 RELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALS-PLSKGSMEA-GPYL 1200
REL+ C HP R+ FLRH QF +YA Y K++ + + +++ K +A G +L
Sbjct: 714 RELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHL 773
Query: 1201 PRA--LQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEA 1258
A L +P++++ +Y LL+EL R G + E AL A L+ Q G DLLA++A
Sbjct: 774 DLASYLLKPIQRMGKYALLLQELARACGGP-TQELSALREAQSLVHFQLRHGNDLLAMDA 832
Query: 1259 VRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQA 1318
++GC+++LKEQGQL+ +D F V GR K +R +FLFE LLLFSK + G + F YK++
Sbjct: 833 IQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRS 892
Query: 1319 FKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHN 1378
FK AD+GLTE G+S L FE+WFRRR+AR+ + LQA+S IK WT+ I+ LLWRQA HN
Sbjct: 893 FKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHN 952
Query: 1379 KELRVQQMVSMGIGNKPFLDI----KALGERTLSALLTGRAARTRASVAVSSFEH----- 1429
KE+R+ +MVSMG+GNK F DI +A+ +RT++ +L R R+RAS+AV+ F+H
Sbjct: 953 KEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYL 1012
Query: 1430 -AGPSLPGLSPGACSL 1444
A SLPG P +CS+
Sbjct: 1013 GASNSLPG-DPASCSV 1027
>gi|148529025 pleckstrin homology domain containing, family G (with
RhoGef domain) member 4B [Homo sapiens]
Length = 1271
Score = 378 bits (970), Expect = e-104
Identities = 352/1164 (30%), Positives = 532/1164 (45%), Gaps = 146/1164 (12%)
Query: 371 TPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHL 430
TP RTG G AAGR L R S +P A Q A + S P HL
Sbjct: 64 TPSRTGPG------AAGR-TLPRRSRSWERAPRSSRGA--QAAACHTSHHSAGSRPGGHL 114
Query: 431 VKEEYEGSGKPESEPKELKTAGEKEPQL-SEACGPTEEGAGERELEGPGLLCMAGHTGPE 489
+ G P P E ++E L S AC T+ G+ L +GP
Sbjct: 115 GGQAV---GTPNCVPVEGPGCTKEEDVLASSACVSTDGGS----------LHCHNPSGPS 161
Query: 490 GPLSDTPTPPLETVQEGKGD---NIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSG 546
+ P P E G GD +P++ L DV+ +L+ SG + L G D+ G
Sbjct: 162 DVPARQPHPEQEGWPPGTGDFPSQVPKQVL--------DVSQELLQSGVVTLPGTRDRHG 213
Query: 547 RALLTI-TPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALI 605
RA++ + T S L L Y HS+ R +++ LGL VL+D R++P P A+
Sbjct: 214 RAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVVLVDARRSPAAP-AVS 272
Query: 606 PALSQLQDSGDPPLVQRLLILIHDDL---PTELCGFQGAEVLSENDLKRVAKPEELQWEL 662
ALS LQ++ P ++ +L+L+ + P + Q V S + + +L +L
Sbjct: 273 QALSGLQNNTSP-IIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVDSCQLTADL 331
Query: 663 GGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEP----EEEEAVGMPKP 718
G S W+ Q + C+ + ++ + L P E E + +
Sbjct: 332 DGSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELIDQHET 391
Query: 719 LQK-VLADPRLTALQRDGGAILMRLR----STPSSKLEGQGPATLYQEVDEAIHQLVRLS 773
+ K VL DP L +L+ +GG +L RLR T S+ + +LY VDE +H+LV S
Sbjct: 392 MMKLVLEDPLLVSLRLEGGTVLARLRREELGTEDSRDTLEAATSLYDRVDEEVHRLVLTS 451
Query: 774 NLHVQQQEQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQE 833
N +QQ E + L L + S QLA P T +Q+ R SA V +
Sbjct: 452 NNRLQQLEHLRELASLLEGNDQQSCQKGLQLAK-ENPQRTEEMVQDFR---RGLSAVVSQ 507
Query: 834 RLAQAREALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLA 893
A+ RE L S ++ + + ++ + + + H+ E + A
Sbjct: 508 --AECREG-ELARWTRSSELCETVSSWMGPLDPEACPSSPVAECLRSCHQ---EATSVAA 561
Query: 894 GAGPGRE-AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRI 952
A PG AVL AL + + + L L AL E + +
Sbjct: 562 EAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE--ALSEAAPDPSLPPLAQSPP 619
Query: 953 QQHVGEEASPRGYRRRRADGASSGGAQWGPRSP------------------SPSLSSL-- 992
+ +EA R + SGG W P P P L +L
Sbjct: 620 KHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWD 679
Query: 993 ---LLPSSPGPRPAPSH------CSLAPCG------------------EDYEEEGPELAP 1025
LL PG +H CS P + +E P+ P
Sbjct: 680 PLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGP 739
Query: 1026 EAEGRPPR-AVLIRGLEVTSTEVVDRTCSPREHVL---LGRARGPDGPWGVGTPRMERKR 1081
+P +V +GLEVTST ++ +H + ++R P G+ + ++
Sbjct: 740 RDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQSRSLSSPSGLHPAEEDGRQ 799
Query: 1082 SISAQQ--RLVSELIACEQDYVATLSEPVPPPGPE-----LTPELRGTWAAALSARERLR 1134
+ + + +++E+IA E++Y+ L + PE L LRG E+L
Sbjct: 800 QVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDLPQGLRGKHHVIFGNLEKLH 859
Query: 1135 SFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSP--LSKG 1192
FH+ HFLREL+ C PL +G FLRH +QF +Y Y K++ + + L++
Sbjct: 860 DFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDK 919
Query: 1193 SMEAGPYLPRA--LQQPLEQLTRYGRLLEELLREAGPELSS--ECRALGAAVQLLREQEA 1248
E G + A L +P++++ +Y LL++LL+EA L+ E L AA ++ Q
Sbjct: 920 QRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQGQELGELRAAEVVVCFQLR 979
Query: 1249 RGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEG 1308
G DLLA++A+RGC+++LKEQGQL RD F V CGRKK LRHVFLFE L+LFSK + EG
Sbjct: 980 HGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLRHVFLFEDLILFSKTQKVEG 1039
Query: 1309 GSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRR-AREAYTLQATSPEIKLKWTSSI 1367
++++YKQ+FKTA++G+TEN+GDSGL FE+WFRRRR +++ Y LQA+S E+K WT I
Sbjct: 1040 SHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRRKSQDTYILQASSAEVKSAWTDVI 1099
Query: 1368 AQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIK-------------------ALGERTLS 1408
++LWRQA ++ELR+Q+M SMGIGN+PF+D+K + +R
Sbjct: 1100 GRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDCAVISDRAPKCAVMSDRVPD 1159
Query: 1409 ALLTGRAARTRASVAVSSFEHAGP 1432
+++ G ++ R S AVSS +HA P
Sbjct: 1160 SIVKGTESQMRGSTAVSSSDHAAP 1183
Score = 37.7 bits (86), Expect = 0.085
Identities = 41/157 (26%), Positives = 53/157 (33%), Gaps = 26/157 (16%)
Query: 222 LGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG 281
LGT + G GP G D + +P L + R P+R G G G
Sbjct: 32 LGTGAVASGTQEETSGPRG-----------------DPQQTPSLEKERHTPSRTGPGAAG 74
Query: 282 R--HRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAE 339
R RR R+W + RG A S G+ P G +AV + V P
Sbjct: 75 RTLPRRSRSW-ERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVGTPNCVPVEGPGCT 133
Query: 340 AVGE--ASGSCPLRPGELRGGGGGGQGAEGPPGTPRR 374
+ AS +C GG GP P R
Sbjct: 134 KEEDVLASSACV----STDGGSLHCHNPSGPSDVPAR 166
>gi|71274186 hypothetical protein LOC85449 [Homo sapiens]
Length = 1200
Score = 260 bits (664), Expect = 8e-69
Identities = 278/944 (29%), Positives = 400/944 (42%), Gaps = 134/944 (14%)
Query: 1 MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA 60
M+P ++ +Q LA LYPPFEATAPT+LGQVF++++ ++ D L + LDFL+PAK L
Sbjct: 1 MDPPSLDTAIQHALAGLYPPFEATAPTVLGQVFRLLDSGFQGDGLSFLLDFLIPAKRLCE 60
Query: 61 KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA 120
+V++ ACA YS LF HEGWPLCL ++VVV LA L LLR GDFYLQV P Q+ +
Sbjct: 61 QVREAACAPYSHCLFLHEGWPLCLRDEVVVHLAPLNPLLLRQGDFYLQVEPQEEQSVCIM 120
Query: 121 LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE 180
+KCL+ V + PVP A LFT EWL+ IN D L CL+++ +GI +PW +
Sbjct: 121 IKCLSLDLCTVDKKPVPEPAYPILFTQEWLEAINSDFEGNPLHNCLVASENGIAPVPWTK 180
Query: 181 LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPP------------LPEEAL------ 222
+ P FV +V P LP L SP LP ++L
Sbjct: 181 ITSPEFVDDRPQVVNALCQAWGP-LPLEALDLSSPQELHQASSPDNQVLPAQSLAKGKGR 239
Query: 223 --GTRSPG--------------DGHNAPVEGPEGEYVELLEVTLPVRG-SPTDAEGSPGL 265
G++ PG + EG+YV LL + RG SP+ G+
Sbjct: 240 TYGSKYPGLIKVEQARCGEVAFRMDEVVSQDFEGDYVALLGFSQESRGESPSREAGTS-- 297
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAW-MHQKGLGPRGQDGA---------RPPGEGSSTGAS 315
S + + AG K + + + GP + A RP G +
Sbjct: 298 SGCTSGALEEIAGTKETPLFQKILPLSEANEGPSLGNRACTKPESSEERPYNLGFRRKVN 357
Query: 316 PESPP-GAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRR 374
++P +E P+ + + V E +A+ ASG LR G + +GP G P
Sbjct: 358 LKAPTHNSERPPQGSYMNVLE---DALDCASG---LRAGVSQEPAASKM--QGPLGNPEN 409
Query: 375 TGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP--------SEHKLP 426
+ R R A LS +A S K + +E G LP P S + P
Sbjct: 410 MVQ-LRPGPRQASSPRLSPASPAAAASE-TKIEVKTKERNGRLPKPMPCPSRNTSSPEPP 467
Query: 427 ECHLVKEEYEGSGKPESEP-----------KELKTAGEKEPQLSEACGPTEEGAGERELE 475
L G +P P K L + +P +++ G + G + +
Sbjct: 468 TPGLKFSFLRGQRQPSVTPEKASLQHNGPWKVLCSLYSPKPNRAKSLG--KAGTTQTKTS 525
Query: 476 GPGLLCMAGHTGPEGPLSD--TPTPPLETVQEGKGDNIPEE---------ALAVSVSDHP 524
GP T P PL++ P +G + EE AL V V
Sbjct: 526 GPA-------TAP-SPLTEEKAALPEASAGSPERGPTLEEEPPGPEPRIGALGVKV---- 573
Query: 525 DVAWDLMASGFLILTGGVDQSGRALLTI-TPPCPPEEPPPSRDTLNTTLHYLHSLLRPDL 583
S L GG D++GR LL + T E P + + L YL ++ RP+
Sbjct: 574 ------FRSRIACLPGGRDRAGRPLLLVSTTEGAWEAPWCTVSEVTKLLSYLCTIPRPED 627
Query: 584 QTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEV 643
+ GL+VL+D R+ PP P L+ AL Q + P ++ +L L + +L +V
Sbjct: 628 KAKGLAVLIDARRQPP-QPGLVSAL-QATQAQVPASIRAILFLGEKEAALQLQTLPDVQV 685
Query: 644 LSENDLKRVA---KPEELQWELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEE 700
LK ++ P +L L G + WV Q++ ++ +IEE
Sbjct: 686 EVLTSLKALSHHVDPSQLPAVLEGPFPYCHTEWVHFFQKLDPFLADLHQASSLLQASIEE 745
Query: 701 LEGAAEP----EEEEAVGMPKPL-QKVLADPRLTALQRDGGAILMRLRS-------TPSS 748
E A P E + K L + VL DP L LQR+GGA L RL+ +P
Sbjct: 746 FEKADPPGGMQEATRCLSKSKELMEAVLRDPGLLGLQREGGATLARLQHDASRLDFSPDV 805
Query: 749 KLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQ----QVLQWLSGPGEEQL 804
+ LY VDE +H LV SN + + E R L RL+ QV W+ G L
Sbjct: 806 RSHLAAATALYSLVDEQLHVLVTASNSLLGKLELRVRLGRLEAAIHQVSDWMEQEGRRCL 865
Query: 805 ASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENA 848
S +L +++ F F + AQ R L L + A
Sbjct: 866 QSLTPKDGSLETVEKAHAEFENFFLQA---AAQYRRGLELSKQA 906
>gi|163644325 MCF.2 cell line derived transforming sequence-like
isoform a [Homo sapiens]
Length = 1182
Score = 121 bits (304), Expect = 4e-27
Identities = 233/1055 (22%), Positives = 397/1055 (37%), Gaps = 180/1055 (17%)
Query: 529 DLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGL 588
D + F L+GG Q G ++T P P P ++ N + YL S+ P LQ G+
Sbjct: 101 DQLKKRFAYLSGGRGQDGSPVITF-PDYPAFSEIPDKEFQNV-MTYLTSI--PSLQDAGI 156
Query: 589 SVLLD---------------LRQAPPLPPALIPALSQLQDSGDPPLVQRLLILI-----H 628
+L LR A P A + + L+ +G QR L I
Sbjct: 157 GFILVIDRRRDKWTSVKASVLRIAASFP-ANLQLVLVLRPTG---FFQRTLSDIAFKFNR 212
Query: 629 DDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWV---EIHQEVVRLCR 685
DD ++ + V DL +L +LGG D S W+ + + +
Sbjct: 213 DDFKMKVPVIMLSSV---PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVK 269
Query: 686 LCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRST 745
+L S + E E + + +V +K A L ++G ++L LR
Sbjct: 270 QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLREL 329
Query: 746 PSSKLEGQGPATLYQEVDE--AIHQLVRLSN-----------LHVQQQEQRQCLRRLQQV 792
+ EG P+ ++D + +L+ N H Q+ EQ LR +Q
Sbjct: 330 QA---EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQG 386
Query: 793 LQWLSG---PGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALE-ENA 848
+ + +++A+F G++L+ ++ +F + + +AR AL+L+ E
Sbjct: 387 FREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERAR-ALSLDGEQL 445
Query: 849 TSQK----------------VLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARL 892
K + D F + + L ++L L R + + +W DEG L
Sbjct: 446 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLL 505
Query: 893 AG-------AGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARC 945
A + G EA L + + + QE+ A+ + S
Sbjct: 506 ASQPVDKCQSQDGAEAALQEIE-KFLETGAENKIQELNAIYKEYESILN----------- 553
Query: 946 QELERRIQQHVGEEASPRG-YRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAP 1004
Q+L +++ ++AS + RR+A Q P P P P
Sbjct: 554 QDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVA--------------PRP 599
Query: 1005 SHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRAR 1064
+ +PC G E + G R R S R + E L R
Sbjct: 600 EALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILR 659
Query: 1065 GPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWA 1124
R + ++ V EL+ + Y A + P+ L+ L
Sbjct: 660 -----------RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM--AHLLSTGLHNKKD 706
Query: 1125 AALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLA 1184
E + FH FLREL+ P +G CFL + F +Y +Y +++ + E+
Sbjct: 707 VLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWR 766
Query: 1185 ALSPL-----SKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLR-----EAGPELSSECR 1234
S + ++ L L +P++++T+Y LL+E+L+ E +L
Sbjct: 767 QCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQ---E 823
Query: 1235 ALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------- 1286
AL + + +L+ D + + A+ G + +L + G+LL + F+V K+
Sbjct: 824 ALSSILGILKAV----NDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKEL 879
Query: 1287 -----CLRHVFLFEHLLLFSKLKGPEG----GSEMFVYKQAFKTADMGLTENIGDSGLCF 1337
RH+FL E +LF K + G + + YKQ+ A +G+TEN+ F
Sbjct: 880 ARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKF 939
Query: 1338 ELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLL------WRQAAHNKELRVQQMV---- 1387
E+W+ R E Y +QA +PEIK W + I ++L R+A+ ++ L Q +
Sbjct: 940 EIWYNAR--EEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPA 997
Query: 1388 ----SMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACS 1443
S GN +IK L ER L V+ + G S + S
Sbjct: 998 PTSTSPSRGNS--RNIKKLEERKTDPL------SLEGYVSSAPLTKPPEKGKGWSKTSHS 1049
Query: 1444 LPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPR 1478
L A ++ W +QI+ + D+ D GP+
Sbjct: 1050 LEAPEDDGGWSSAEEQIN----SSDAEEDGGLGPK 1080
>gi|163644323 MCF.2 cell line derived transforming sequence-like
isoform b [Homo sapiens]
Length = 1129
Score = 121 bits (304), Expect = 4e-27
Identities = 233/1055 (22%), Positives = 397/1055 (37%), Gaps = 180/1055 (17%)
Query: 529 DLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGL 588
D + F L+GG Q G ++T P P P ++ N + YL S+ P LQ G+
Sbjct: 48 DQLKKRFAYLSGGRGQDGSPVITF-PDYPAFSEIPDKEFQNV-MTYLTSI--PSLQDAGI 103
Query: 589 SVLLD---------------LRQAPPLPPALIPALSQLQDSGDPPLVQRLLILI-----H 628
+L LR A P A + + L+ +G QR L I
Sbjct: 104 GFILVIDRRRDKWTSVKASVLRIAASFP-ANLQLVLVLRPTG---FFQRTLSDIAFKFNR 159
Query: 629 DDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWV---EIHQEVVRLCR 685
DD ++ + V DL +L +LGG D S W+ + + +
Sbjct: 160 DDFKMKVPVIMLSSV---PDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVK 216
Query: 686 LCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRST 745
+L S + E E + + +V +K A L ++G ++L LR
Sbjct: 217 QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLREL 276
Query: 746 PSSKLEGQGPATLYQEVDE--AIHQLVRLSN-----------LHVQQQEQRQCLRRLQQV 792
+ EG P+ ++D + +L+ N H Q+ EQ LR +Q
Sbjct: 277 QA---EGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQG 333
Query: 793 LQWLSG---PGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALE-ENA 848
+ + +++A+F G++L+ ++ +F + + +AR AL+L+ E
Sbjct: 334 FREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERAR-ALSLDGEQL 392
Query: 849 TSQK----------------VLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARL 892
K + D F + + L ++L L R + + +W DEG L
Sbjct: 393 IGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLL 452
Query: 893 AG-------AGPGREAVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARC 945
A + G EA L + + + QE+ A+ + S
Sbjct: 453 ASQPVDKCQSQDGAEAALQEIE-KFLETGAENKIQELNAIYKEYESILN----------- 500
Query: 946 QELERRIQQHVGEEASPRG-YRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAP 1004
Q+L +++ ++AS + RR+A Q P P P P
Sbjct: 501 QDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVA--------------PRP 546
Query: 1005 SHCSLAPCGEDYEEEGPELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRAR 1064
+ +PC G E + G R R S R + E L R
Sbjct: 547 EALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILR 606
Query: 1065 GPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWA 1124
R + ++ V EL+ + Y A + P+ L+ L
Sbjct: 607 -----------RHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM--AHLLSTGLHNKKD 653
Query: 1125 AALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLA 1184
E + FH FLREL+ P +G CFL + F +Y +Y +++ + E+
Sbjct: 654 VLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWR 713
Query: 1185 ALSPL-----SKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLR-----EAGPELSSECR 1234
S + ++ L L +P++++T+Y LL+E+L+ E +L
Sbjct: 714 QCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQ---E 770
Query: 1235 ALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------- 1286
AL + + +L+ D + + A+ G + +L + G+LL + F+V K+
Sbjct: 771 ALSSILGILKAV----NDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKEL 826
Query: 1287 -----CLRHVFLFEHLLLFSKLKGPEG----GSEMFVYKQAFKTADMGLTENIGDSGLCF 1337
RH+FL E +LF K + G + + YKQ+ A +G+TEN+ F
Sbjct: 827 ARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKF 886
Query: 1338 ELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLL------WRQAAHNKELRVQQMV---- 1387
E+W+ R E Y +QA +PEIK W + I ++L R+A+ ++ L Q +
Sbjct: 887 EIWYNAR--EEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPA 944
Query: 1388 ----SMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACS 1443
S GN +IK L ER L V+ + G S + S
Sbjct: 945 PTSTSPSRGNS--RNIKKLEERKTDPL------SLEGYVSSAPLTKPPEKGKGWSKTSHS 996
Query: 1444 LPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPR 1478
L A ++ W +QI+ + D+ D GP+
Sbjct: 997 LEAPEDDGGWSSAEEQIN----SSDAEEDGGLGPK 1027
>gi|162287076 RhoA/RAC/CDC42 exchange factor isoform 3 [Homo sapiens]
Length = 619
Score = 114 bits (285), Expect = 7e-25
Identities = 153/588 (26%), Positives = 238/588 (40%), Gaps = 94/588 (15%)
Query: 950 RRIQQH--VGEEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSLLLPSSPGPRPAP 1004
RR ++H + P Y ++G+ S A G P PS LSS P SPGP P P
Sbjct: 57 RRDREHEVLAGALQPESYSIAGSEGSISASAASGLAAPSGPSSGLSSG--PCSPGP-PGP 113
Query: 1005 -----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRAVLIRGLEVTSTE 1046
HC D + GP L P E P +L LE
Sbjct: 114 VSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPG-- 171
Query: 1047 VVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSE 1106
D+T P E L ++ P+ + ++K+++ ++SEL+ E+ YV L +
Sbjct: 172 --DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELVETEKMYVDDLGQ 220
Query: 1107 PVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLR 1161
V + PE LRG +++ +HR +FL+ELQ C P + F++
Sbjct: 221 IVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIK 280
Query: 1162 HGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQQPLEQLTRYGRL 1217
H + +Y Y +++ K E+ ++ S + + G L L +P++++ +Y L
Sbjct: 281 HERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLL 340
Query: 1218 LEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLH 1274
L++ L+ AG + + L AV+++ R D++ + +RG E L QG+LL
Sbjct: 341 LKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLG 396
Query: 1275 RDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM-FVYKQAFKTADM 1324
+D F V + + R VFLFE +++FS+ G GG++ +VYK + K + +
Sbjct: 397 QDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCL 456
Query: 1325 GLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKEL-- 1381
GL N+ F L R + Y LQA P I W +AQ+L Q L
Sbjct: 457 GLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQS 516
Query: 1382 ------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHA--GPS 1433
R Q S+G P + G R R H S
Sbjct: 517 PIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQAQGSTHTPINGS 561
Query: 1434 LPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481
LP L S V LD + + P+ S VSP P+ P
Sbjct: 562 LPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 606
>gi|150417975 RhoA/RAC/CDC42 exchange factor isoform 1 [Homo sapiens]
Length = 580
Score = 113 bits (282), Expect = 2e-24
Identities = 155/600 (25%), Positives = 240/600 (40%), Gaps = 97/600 (16%)
Query: 939 GRCQARCQELERRIQQHVG---EEASPRGYRRRRADGASSGGAQWG---PRSPSPSLSSL 992
GRC C + R++ G Y ++G+ S A G P PS LSS
Sbjct: 8 GRCA--CPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSG 65
Query: 993 LLPSSPGPRPAP-----------SHCSLAPCGEDYEEEGPE----LAPE---AEGRPPRA 1034
P SPGP P P HC D + GP L P E P
Sbjct: 66 --PCSPGP-PGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELT 122
Query: 1035 VLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQRLVSELI 1094
+L LE D+T P E L ++ P+ + ++K+++ ++SEL+
Sbjct: 123 LLTTLLEGPG----DKTQPPEEETL---SQAPE------SEEEQKKKALERSMYVLSELV 169
Query: 1095 ACEQDYVATLSEPVP----PPGPELTPE-LRGTWAAALSARERLRSFHRTHFLRELQGCA 1149
E+ YV L + V + PE LRG +++ +HR +FL+ELQ C
Sbjct: 170 ETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCL 229
Query: 1150 THPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAAL--SPLSKGSMEAGP--YLPRALQ 1205
P + F++H + +Y Y +++ K E+ ++ S + + G L L
Sbjct: 230 KDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLI 289
Query: 1206 QPLEQLTRYGRLLEELLR---EAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGC 1262
+P++++ +Y LL++ L+ AG + + L AV+++ R D++ + +RG
Sbjct: 290 KPVQRIMKYQLLLKDFLKYYNRAGMDTAD----LEQAVEVMCFVPKRCNDMMTLGRLRGF 345
Query: 1263 EIDLKEQGQLLHRDPFTV-------ICGRKKCLRHVFLFEHLLLFSKL--KGPEGGSEM- 1312
E L QG+LL +D F V + + R VFLFE +++FS+ G GG++
Sbjct: 346 EGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPG 405
Query: 1313 FVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR-EAYTLQATSPEIKLKWTSSIAQLL 1371
+VYK + K + +GL N+ F L R + Y LQA P I W +AQ+L
Sbjct: 406 YVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQIL 465
Query: 1372 WRQAAHNKEL--------RVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVA 1423
Q L R Q S+G P + G R R
Sbjct: 466 ESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGV---------------GSPGRIRLGDQ 510
Query: 1424 VSSFEHA--GPSLPGLSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSP 1481
H SLP L S V LD + + P+ S VSP P+ P
Sbjct: 511 AQGSTHTPINGSLPSL---LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPP 567
>gi|153791628 MCF.2 cell line derived transforming sequence isoform a
[Homo sapiens]
Length = 985
Score = 105 bits (261), Expect = 4e-22
Identities = 87/327 (26%), Positives = 149/327 (45%), Gaps = 49/327 (14%)
Query: 1086 QQRLVSELIACEQDYV-----ATLSEPVPPPGPEL----TPELRGTWAAALSARERLRSF 1136
+ +++ELI E+ YV L PE+ P LR + F
Sbjct: 556 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 615
Query: 1137 HRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLEN-----GLAALSPLSK 1191
H FL L+ CA P R+G CFL D F +YA+Y +++ + E A +
Sbjct: 616 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 675
Query: 1192 GSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSEC-------RALGAAVQLLR 1244
++ L L +P++++T+Y LL+ELL+ S +C +AL A + LL+
Sbjct: 676 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-----YSKDCEGSALLKKALDAMLDLLK 730
Query: 1245 EQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------------CLRHV 1291
D + A+ G +L E G+++ + F+V G KK RH+
Sbjct: 731 SV----NDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHL 786
Query: 1292 FLFEHLLLFSKLKGPEG-GSE---MFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR 1347
FL+E ++F K + G GS+ + +K +K ++G+TE + FE+W+ +
Sbjct: 787 FLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK--E 844
Query: 1348 EAYTLQATSPEIKLKWTSSIAQLLWRQ 1374
E Y +QA++ ++K+ W I +L +Q
Sbjct: 845 EVYIVQASNVDVKMTWLKEIRNILLKQ 871
>gi|153791325 MCF.2 cell line derived transforming sequence isoform b
[Homo sapiens]
Length = 925
Score = 105 bits (261), Expect = 4e-22
Identities = 87/327 (26%), Positives = 149/327 (45%), Gaps = 49/327 (14%)
Query: 1086 QQRLVSELIACEQDYV-----ATLSEPVPPPGPEL----TPELRGTWAAALSARERLRSF 1136
+ +++ELI E+ YV L PE+ P LR + F
Sbjct: 496 KNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEF 555
Query: 1137 HRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLEN-----GLAALSPLSK 1191
H FL L+ CA P R+G CFL D F +YA+Y +++ + E A +
Sbjct: 556 HNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQ 615
Query: 1192 GSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSEC-------RALGAAVQLLR 1244
++ L L +P++++T+Y LL+ELL+ S +C +AL A + LL+
Sbjct: 616 RKLKHRLRLDSYLLKPVQRITKYQLLLKELLK-----YSKDCEGSALLKKALDAMLDLLK 670
Query: 1245 EQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKK-------------CLRHV 1291
D + A+ G +L E G+++ + F+V G KK RH+
Sbjct: 671 SV----NDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHL 726
Query: 1292 FLFEHLLLFSKLKGPEG-GSE---MFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAR 1347
FL+E ++F K + G GS+ + +K +K ++G+TE + FE+W+ +
Sbjct: 727 FLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEK--E 784
Query: 1348 EAYTLQATSPEIKLKWTSSIAQLLWRQ 1374
E Y +QA++ ++K+ W I +L +Q
Sbjct: 785 EVYIVQASNVDVKMTWLKEIRNILLKQ 811
>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
Length = 2986
Score = 102 bits (254), Expect = 3e-21
Identities = 85/322 (26%), Positives = 152/322 (47%), Gaps = 28/322 (8%)
Query: 1078 ERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSAR------- 1130
E+++S ++ +++EL+ E+ YV L E + E+T + L+
Sbjct: 1274 EKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNI 1333
Query: 1131 ERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHK-----LENGLAA 1185
+ + FH FL+EL+ P +G CF+ D+F +Y Y K++ LE+
Sbjct: 1334 QEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF 1393
Query: 1186 LSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELL---REAGPELSSECRALGAAVQL 1242
+ + A + L +P++++T+Y LL+ELL E EL +++
Sbjct: 1394 FDEIQQRHGLANS-ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD-------GLEV 1445
Query: 1243 LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTV----ICGRKKCLRHVFLFEHLL 1298
+ + D + V + G + +L QG+L+ +D F V RK RH+FLFE L
Sbjct: 1446 MLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISL 1505
Query: 1299 LFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYT-LQATSP 1357
+FSK G +VYK T+++G+TE++ F LW R + + T L+A++
Sbjct: 1506 VFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNI 1565
Query: 1358 EIKLKWTSSIAQLLWRQAAHNK 1379
E K +W +I +++ + H K
Sbjct: 1566 ETKQEWIKNIREVIQERIIHLK 1587
Score = 99.4 bits (246), Expect = 2e-20
Identities = 112/441 (25%), Positives = 188/441 (42%), Gaps = 43/441 (9%)
Query: 957 GEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDY 1016
G+E +P+G AD S G WG P S P P P +D
Sbjct: 1808 GDETTPQG---DSADEKSKKG--WGEDEPDEE--------SHTPLPPPMKIFDNDPTQDE 1854
Query: 1017 EEEGPELAPEAEGRPPRAV-LIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVG-- 1073
A +A P A L+ +E ++V S G + P G G
Sbjct: 1855 MSSSLLAARQASTEVPTAADLVNAIE----KLVKNKLSLEGSSYRGSLKDPAGCLNEGMA 1910
Query: 1074 ------TPRMERK-RSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRG 1121
P E+K +++ + +++EL+ E+DYV L V + PE +RG
Sbjct: 1911 PPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRG 1970
Query: 1122 TWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLEN 1181
++ +H+ FL EL+ C R+ F++H + +Y Y +++ + E
Sbjct: 1971 KDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEY 2030
Query: 1182 GLA---ALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGA 1238
+A A K + L L +P++++T+Y LL++ LR + + EC +
Sbjct: 2031 IVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYS-EKAGLECSDIEK 2089
Query: 1239 AVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVI-----CGRKKCLRHVFL 1293
AV+L+ R D++ + ++G E L QG+LL +D F VI + R VFL
Sbjct: 2090 AVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFL 2149
Query: 1294 FEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQ 1353
FE +++FS+L + +++K++ K + L EN+ + F L R E LQ
Sbjct: 2150 FEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVVLQ 2207
Query: 1354 ATSPEIKLKWTSSIAQLLWRQ 1374
A + +I+ W I Q+L Q
Sbjct: 2208 AANADIQQAWVQDINQVLETQ 2228
>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
Length = 1663
Score = 102 bits (254), Expect = 3e-21
Identities = 85/322 (26%), Positives = 152/322 (47%), Gaps = 28/322 (8%)
Query: 1078 ERKRSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSAR------- 1130
E+++S ++ +++EL+ E+ YV L E + E+T + L+
Sbjct: 1274 EKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHIIFGNI 1333
Query: 1131 ERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHK-----LENGLAA 1185
+ + FH FL+EL+ P +G CF+ D+F +Y Y K++ LE+
Sbjct: 1334 QEIYDFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF 1393
Query: 1186 LSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELL---REAGPELSSECRALGAAVQL 1242
+ + A + L +P++++T+Y LL+ELL E EL +++
Sbjct: 1394 FDEIQQRHGLANS-ISSYLIKPVQRITKYQLLLKELLTCCEEGKGELKD-------GLEV 1445
Query: 1243 LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTV----ICGRKKCLRHVFLFEHLL 1298
+ + D + V + G + +L QG+L+ +D F V RK RH+FLFE L
Sbjct: 1446 MLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAFQVWDPKSLIRKGRERHLFLFEISL 1505
Query: 1299 LFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYT-LQATSP 1357
+FSK G +VYK T+++G+TE++ F LW R + + T L+A++
Sbjct: 1506 VFSKEIKDSSGHTKYVYKNKLLTSELGVTEHVEGDPCKFALWSGRTPSSDNKTVLKASNI 1565
Query: 1358 EIKLKWTSSIAQLLWRQAAHNK 1379
E K +W +I +++ + H K
Sbjct: 1566 ETKQEWIKNIREVIQERIIHLK 1587
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 102 bits (253), Expect = 4e-21
Identities = 129/542 (23%), Positives = 226/542 (41%), Gaps = 65/542 (11%)
Query: 998 PGPRPAPSHCSLAPCGEDYEEEGPELA-PEAEGRPPRAVLIRGLEVT-----------ST 1045
P P H L P +D + L P + P A L+ +E S+
Sbjct: 1870 PPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSS 1929
Query: 1046 EVVDR------TCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQR--LVSELIACE 1097
+VD+ + +P ++ LL + D ME ++S S ++R ++ EL+ E
Sbjct: 1930 LLVDQGDSSSPSFNPSDNSLLSSSSPID--------EMEERKSSSLKRRHYVLQELVETE 1981
Query: 1098 QDYVATLSEPVPP-----PGPELTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHP 1152
+DYV L V + +++G ++ +HR FL EL+ C P
Sbjct: 1982 RDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDP 2041
Query: 1153 LRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPL----SKGSMEAGPYLPRALQQPL 1208
++G+ F++H + +Y Y +++ K E+ ++ K + L L +P+
Sbjct: 2042 EKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIKPV 2101
Query: 1209 EQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKE 1268
+++ +Y LL++ L+ + + S + L AV+++ R D++ V ++G + +
Sbjct: 2102 QRIMKYQLLLKDFLKYS-KKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIVA 2160
Query: 1269 QGQLLHRDPFTVICGRKKCL-----RHVFLFEHLLLFSKLKGPEGGSEM--FVYKQAFKT 1321
QG+LL +D F V L R +FLFE +++FS+ + G M F++K + K
Sbjct: 2161 QGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKV 2220
Query: 1322 ADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQA----AH 1377
+ + L EN+ + F L R E + L ++SP ++ W I Q+L Q A
Sbjct: 2221 SCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNAL 2280
Query: 1378 NKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGL 1437
+ Q+ S G G G S G + + + S GPS G
Sbjct: 2281 TSPIEYQRNHSGGGGG---------GGSGGSG--GGGGSGGGGAPSGGSGHSGGPSSCGG 2329
Query: 1438 SPGAC-SLPARVEEEAWDLDVKQISLA----PETLDSSGDVSPGPRNSPSLQPPHPGSST 1492
+P S P+R+ + +S A E SG +PGP P P G S
Sbjct: 2330 APSTSRSRPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSA 2389
Query: 1493 PT 1494
P+
Sbjct: 2390 PS 2391
Score = 101 bits (251), Expect = 6e-21
Identities = 83/324 (25%), Positives = 150/324 (46%), Gaps = 32/324 (9%)
Query: 1078 ERKRSISAQQRLVSELIACEQDYVATLSE-------PVPPPGPELTPELRGTWAAALSAR 1130
E+++S ++ +++ELI E+ YV L E + E+ P +
Sbjct: 1285 EKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFGNM 1344
Query: 1131 ERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHK-----LENGLAA 1185
+ + FH FL+EL+ P +G CF+ D+F +Y Y K++ LE+ +
Sbjct: 1345 QEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAGSY 1404
Query: 1186 LSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELL---REAGPELSSECRALGAAVQL 1242
+ + A + L +P++++T+Y LL+ELL E E+ +++
Sbjct: 1405 FDEIQQRHGLANS-ISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKD-------GLEV 1456
Query: 1243 LREQEARGRDLLAVEAVRGCEIDLKEQGQLLHR------DPFTVICGRKKCLRHVFLFEH 1296
+ R D + + + G + +++ QG+L+ + DP T+I RK RH+FLFE
Sbjct: 1457 MLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKTLI--RKGRERHLFLFEM 1514
Query: 1297 LLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRARE-AYTLQAT 1355
L+FSK G ++YK T+++G+TE++ F LW R + L+A+
Sbjct: 1515 SLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWVGRTPTSDNKIVLKAS 1574
Query: 1356 SPEIKLKWTSSIAQLLWRQAAHNK 1379
S E K W I +++ + H K
Sbjct: 1575 SIENKQDWIKHIREVIQERTIHLK 1598
Score = 43.9 bits (102), Expect = 0.001
Identities = 84/365 (23%), Positives = 147/365 (40%), Gaps = 51/365 (13%)
Query: 538 LTGGVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQA 597
L+GG D+ G +LT P ++ L + YL + ++ G +V++D+R +
Sbjct: 76 LSGGRDKRGGPILTF--PARSNHDRIRQEDLRRLISYLACIPSEEVCKRGFTVIVDMRGS 133
Query: 598 PPLPPALIPALSQLQDSGDPPLVQRLLILIHDDL-PTELCGFQGAE------VLSENDLK 650
++ P L LQ+S P + LI+ D+ + F ++ ++S L
Sbjct: 134 KW--DSIKPLLKILQESF-PCCIHVALIIKPDNFWQKQRTNFGSSKFEFETNMVSLEGLT 190
Query: 651 RVAKPEELQWELGGHRDPSPSHWVEIH--------QEVVRLCRL--CQGVLGSVRQAIEE 700
+V P +L E G + + W+EI L RL Q +L ++ ++
Sbjct: 191 KVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQDILAK-KELPQD 249
Query: 701 LEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILMRLRSTPS--SKLEGQGPATL 758
LEGA EE + L+K + + L +G +L R++S+ S K G G A L
Sbjct: 250 LEGARNMIEEHS-----QLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGSGNADL 304
Query: 759 YQEVDEAIHQLVRLSNL--------HVQQQEQRQC--LRRLQQ----VLQWLSGPGEEQL 804
+ + L RL + HV++ + QC LR +Q + W++ L
Sbjct: 305 QNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHNKGLFL 364
Query: 805 ASFAMPGDTLSALQETELRFRAFSAEVQ------ERLAQAREALALEENATSQKVLDIFE 858
S+ G + E + + F+ R+ L + SQ++ I
Sbjct: 365 NSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQIRQIAS 424
Query: 859 QRLEQ 863
Q LEQ
Sbjct: 425 Q-LEQ 428
Score = 32.0 bits (71), Expect = 4.7
Identities = 31/149 (20%), Positives = 61/149 (40%), Gaps = 23/149 (15%)
Query: 762 VDEAIHQLVRLSNLHVQQ-----QEQRQCL--RRLQQVLQWLSGPGEEQLASFAMPGDTL 814
+ E +H +L N+ + Q + C+ + +QQVL W+ GE L+ G +L
Sbjct: 541 IHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSL 600
Query: 815 SALQETELRFRAFSAEVQ------ERLAQAREALALEENATSQKV----------LDIFE 858
+ + R F Q ++L +A E LA +++ + F
Sbjct: 601 HRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDFV 660
Query: 859 QRLEQVESGLHRALRLQRFFQQAHEWVDE 887
+R+EQ + L ++ ++ W++E
Sbjct: 661 RRVEQRKILLDMSVSFHTHVKELWTWLEE 689
Score = 31.6 bits (70), Expect = 6.1
Identities = 46/174 (26%), Positives = 60/174 (34%), Gaps = 25/174 (14%)
Query: 197 QPSTLPPELPSGPPGLPSPPLPEEA-----LGTRSPGDGHNAPVEGPEGEYVELLEVTLP 251
+PS +P + PP L S +A GT +PG P PE + P
Sbjct: 2337 RPSRIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAG------PSAP 2390
Query: 252 VRGSP-TDAEGSPGLSRVRTVPTRK--GAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGE 308
R P DAEGS +P K + KG + R G P G+
Sbjct: 2391 SRRPPGADAEGSE--REAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGK 2448
Query: 309 GSSTGASPESPPGAEAVPEAAVLEVSEP-----PAEAVGEASGSCPLRPGELRG 357
+ ASP + P + AVP EP P + G S P P G
Sbjct: 2449 PRAGAASPLNSPLSSAVPSLG----KEPFPPSSPLQKGGSFWSSIPASPASRPG 2498
>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
Length = 1289
Score = 99.4 bits (246), Expect = 2e-20
Identities = 112/441 (25%), Positives = 188/441 (42%), Gaps = 43/441 (9%)
Query: 957 GEEASPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDY 1016
G+E +P+G AD S G WG P S P P P +D
Sbjct: 111 GDETTPQG---DSADEKSKKG--WGEDEPDEE--------SHTPLPPPMKIFDNDPTQDE 157
Query: 1017 EEEGPELAPEAEGRPPRAV-LIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVG-- 1073
A +A P A L+ +E ++V S G + P G G
Sbjct: 158 MSSSLLAARQASTEVPTAADLVNAIE----KLVKNKLSLEGSSYRGSLKDPAGCLNEGMA 213
Query: 1074 ------TPRMERK-RSISAQQRLVSELIACEQDYVATLSEPVPPPGPEL----TPE-LRG 1121
P E+K +++ + +++EL+ E+DYV L V + PE +RG
Sbjct: 214 PPTPPKNPEEEQKAKALRGRMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKGVPEDMRG 273
Query: 1122 TWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLEN 1181
++ +H+ FL EL+ C R+ F++H + +Y Y +++ + E
Sbjct: 274 KDKIVFGNIHQIYDWHKDFFLAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEY 333
Query: 1182 GLA---ALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGA 1238
+A A K + L L +P++++T+Y LL++ LR + + EC +
Sbjct: 334 IVAEYDAYFEEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYS-EKAGLECSDIEK 392
Query: 1239 AVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVI-----CGRKKCLRHVFL 1293
AV+L+ R D++ + ++G E L QG+LL +D F VI + R VFL
Sbjct: 393 AVELMCLVPKRCNDMMNLGRLQGFEGTLTAQGKLLQQDTFYVIELDAGMQSRTKERRVFL 452
Query: 1294 FEHLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQ 1353
FE +++FS+L + +++K++ K + L EN+ + F L R E LQ
Sbjct: 453 FEQIVIFSELLRKGSLTPGYMFKRSIKMNYLVLEENVDNDPCKFAL--MNRETSERVVLQ 510
Query: 1354 ATSPEIKLKWTSSIAQLLWRQ 1374
A + +I+ W I Q+L Q
Sbjct: 511 AANADIQQAWVQDINQVLETQ 531
>gi|31742505 Rho family guanine-nucleotide exchange factor [Homo
sapiens]
Length = 1114
Score = 79.7 bits (195), Expect = 2e-14
Identities = 95/383 (24%), Positives = 166/383 (43%), Gaps = 60/383 (15%)
Query: 1073 GTPRMERKR---SISAQQRLVSELIACEQDYVATLSEPVP----PPG----PELTPELRG 1121
G P +E++ +S ++R++ +L+ E+ Y+ + + P L P++
Sbjct: 604 GNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQ 663
Query: 1122 TWAAALSARER-LRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKL- 1179
L R L FH FL+EL+ CA +P + CFL+ + +Y +Y K+ +
Sbjct: 664 NNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRAR 723
Query: 1180 ----ENGLAALSPLSKGSMEAGPYLPRALQQPLEQLTRYGRLLEELLREAGPE-LSSECR 1234
E A + + ++ L + L+ P ++L +Y LL+ LL PE + +
Sbjct: 724 AIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPG 783
Query: 1235 ALGAAVQ-------------LLREQEARGRDL-----LAVE--AVRGCEIDLKEQGQLLH 1274
LG + + L++ A DL LAV+ AV C D+ + G+LL
Sbjct: 784 ELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLL 843
Query: 1275 RDPFTV------------ICGRKKCLRHVFLFEHLLLFSKLK---GPEGGSEMFVYKQAF 1319
PF+V + K R ++LFE ++F K++ G +G S + +K+
Sbjct: 844 HGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTM 903
Query: 1320 KTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAH-- 1377
K + + + S FE+ R E Y LQA S EI+ W S I++LL Q +
Sbjct: 904 KLMTLSIRQLGRGSHRKFEI--ASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIK 961
Query: 1378 ---NKELRVQQMVSMGIGNKPFL 1397
N + + G G+ P++
Sbjct: 962 DQGNPQFEMSTSKGSGAGSGPWI 984
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 79.0 bits (193), Expect = 3e-14
Identities = 86/355 (24%), Positives = 147/355 (41%), Gaps = 41/355 (11%)
Query: 1061 GRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVP------PPGPE 1114
G A P+ P G E K +S+ ++ EL++ EQ +V L P
Sbjct: 5673 GAAEAPEFP-GEAVSEDEYKARLSS---VIQELLSSEQAFVEELQFLQSHHLQHLERCPH 5728
Query: 1115 LTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVK 1174
+ + G A + FH + FL+ELQ C T + CF+++ F Y +++
Sbjct: 5729 VPIAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDD-DVAMCFIKNQAAFEQYLEFLV 5786
Query: 1175 HRHKLENGLAALS------PLSKGSMEAG-------PYLPRALQQPLEQLTRYGRLLEEL 1221
R + E+ + + + ++ ++ AG P L L+QP+E++ RY LL+EL
Sbjct: 5787 GRVQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKEL 5846
Query: 1222 LREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVI 1281
+R + C L A ++ R + L V + L+ G+ + + F V
Sbjct: 5847 IRNKARNRQN-CALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVW 5905
Query: 1282 CGR-------KKCLRHVFLFE-HLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDS 1333
G K RHVFLF HL++ + + +V++ K + + L + +
Sbjct: 5906 EGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 1334 GLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQL-------LWRQAAHNKEL 1381
FE+W R + Y LQA + IK W I + +WR +EL
Sbjct: 5966 DRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPDFEEEL 6020
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 79.0 bits (193), Expect = 3e-14
Identities = 86/355 (24%), Positives = 147/355 (41%), Gaps = 41/355 (11%)
Query: 1061 GRARGPDGPWGVGTPRMERKRSISAQQRLVSELIACEQDYVATLSEPVP------PPGPE 1114
G A P+ P G E K +S+ ++ EL++ EQ +V L P
Sbjct: 5673 GAAEAPEFP-GEAVSEDEYKARLSS---VIQELLSSEQAFVEELQFLQSHHLQHLERCPH 5728
Query: 1115 LTPELRGTWAAALSARERLRSFHRTHFLRELQGCATHPLRIGACFLRHGDQFSLYAQYVK 1174
+ + G A + FH + FL+ELQ C T + CF+++ F Y +++
Sbjct: 5729 VPIAVAGQKAVIFRNVRDIGRFHSS-FLQELQQCDTDD-DVAMCFIKNQAAFEQYLEFLV 5786
Query: 1175 HRHKLENGLAALS------PLSKGSMEAG-------PYLPRALQQPLEQLTRYGRLLEEL 1221
R + E+ + + + ++ ++ AG P L L+QP+E++ RY LL+EL
Sbjct: 5787 GRVQAESVVVSTAIQEFYKKYAEEALLAGDPSQPPPPPLQHYLEQPVERVQRYQALLKEL 5846
Query: 1222 LREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVI 1281
+R + C L A ++ R + L V + L+ G+ + + F V
Sbjct: 5847 IRNKARNRQN-CALLEQAYAVVSALPQRAENKLHVSLMENYPGTLQALGEPIRQGHFIVW 5905
Query: 1282 CGR-------KKCLRHVFLFE-HLLLFSKLKGPEGGSEMFVYKQAFKTADMGLTENIGDS 1333
G K RHVFLF HL++ + + +V++ K + + L + +
Sbjct: 5906 EGAPGARMPWKGHNRHVFLFRNHLVICKPRRDSRTDTVSYVFRNMMKLSSIDLNDQVEGD 5965
Query: 1334 GLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQL-------LWRQAAHNKEL 1381
FE+W R + Y LQA + IK W I + +WR +EL
Sbjct: 5966 DRAFEVWQEREDSVRKYLLQARTAIIKSSWVKEICGIQQRLALPVWRPPDFEEEL 6020
>gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo
sapiens]
Length = 1818
Score = 70.9 bits (172), Expect = 9e-12
Identities = 94/342 (27%), Positives = 120/342 (35%), Gaps = 53/342 (15%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGT-------------RSPGDGHNAPVEGPEGEYVE 244
P P P GP G P P ++G+ +PG A V GP+GE E
Sbjct: 1233 PGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGE 1292
Query: 245 LLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLG-PRGQDG- 302
E P P A+G PG + P G G Q G+G +G+DG
Sbjct: 1293 KGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGD 1352
Query: 303 -ARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGG 361
+P G S A P PPG P AA E + A GEA P PG + G G
Sbjct: 1353 PGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGP--PG--KTGPVG 1408
Query: 362 GQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPL----------SPGDKEDASHQ 411
QG G PG G ++ GA + G P+ PG K + H
Sbjct: 1409 PQGPAGKPGPEGLRGIPGPVGEQGL-PGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHP 1467
Query: 412 EALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGE 471
+G + P E + E G P ++ P + GP G
Sbjct: 1468 GLIGLIGPPGE---------QGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP----PGP 1514
Query: 472 RELEGP-GLLCMAGHTGPEGPLSD--------TPTPPLETVQ 504
L GP G G TGP G D +P PP E +Q
Sbjct: 1515 PGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQ 1556
Score = 59.3 bits (142), Expect = 3e-08
Identities = 96/350 (27%), Positives = 123/350 (35%), Gaps = 48/350 (13%)
Query: 198 PSTLP-PELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSP 256
P LP P+ P GPPG P G PG G EG+ E + P P
Sbjct: 710 PQGLPGPQGPIGPPGEKGPQGKPGLAGL--PGADGPPGHPGKEGQSGEKGALGPPGPQGP 767
Query: 257 TDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP 306
G G+ VR + KG G+ + M KG +GPRG+DG P
Sbjct: 768 IGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDG--PE 825
Query: 307 GEGSSTGASPESPPGAEAVPEAAVLEVSEP--PAEAVGEASGSCPLRPGELRGGGGGGQG 364
G G + + P +A + + P P + S P PG G G +G
Sbjct: 826 GPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGA--NGEKGARG 883
Query: 365 AEGPPGTPRRTGKGNRRKKRAAGRGALSR-------GGDSAPLSPGDKEDASHQEALGNL 417
G PG + G R R A RG + GGD P PG++ Q +G
Sbjct: 884 VAGKPGPRGQRGPTGPRGSRGA-RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVG-F 941
Query: 418 PSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTEEGA--GEREL 474
P P K P K+ G E G P + GPT E GER
Sbjct: 942 PGP---KGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGER-- 996
Query: 475 EGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHP 524
GH GP GP + P + KGD P+ +S D P
Sbjct: 997 ---------GHPGPPGPPGEQGLPGAAGKEGAKGDPGPQ---GISGKDGP 1034
Score = 58.2 bits (139), Expect = 6e-08
Identities = 95/335 (28%), Positives = 114/335 (34%), Gaps = 62/335 (18%)
Query: 206 PSGPPGLPSPP-LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPG 264
P GPPGL P P A G PG + G +G+ RG P G G
Sbjct: 1160 PPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDE--------GARGFP-GPPGPIG 1210
Query: 265 LSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEA 324
L + P KG G +GP G G R P +G + P+ PPG+
Sbjct: 1211 LQGLPGPPGEKGENGD-----------VGPMGPPGPPGPRGP-QGPNGADGPQGPPGSVG 1258
Query: 325 VPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQ----GAEGPPGTPRRTG-KGN 379
V E EP GEA P PGE GG G+ G GPPG G KG
Sbjct: 1259 -SVGGVGEKGEP-----GEAGNPGP--PGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1310
Query: 380 RRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNL-----------PSPSEHKLPE 427
G G + GD P PG+ A G+ P PS P
Sbjct: 1311 PGDDGPKGNPGPVGFPGDPGP--PGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPP 1368
Query: 428 CHLVKEEYEGSGKPESEPKELKTAGEK----EPQLSEACGPTEEGA-----GERELEGP- 477
K G+ E E GE P + GP G R + GP
Sbjct: 1369 GPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV 1428
Query: 478 ---GLLCMAGHTGPEGPLSDTPTPPLETVQEGKGD 509
GL AG GP GP+ P L+ KG+
Sbjct: 1429 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGE 1463
Score = 56.2 bits (134), Expect = 2e-07
Identities = 93/321 (28%), Positives = 116/321 (36%), Gaps = 51/321 (15%)
Query: 208 GPPGLPSPPLPEEALG-TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
GP G P P+ G T PG A +G G V L P R P + G PG
Sbjct: 817 GPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLG--VPGLP-GYPGRQGPKGSTGFPGFP 873
Query: 267 RVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPG-----EGSSTGASPESPPG 321
+G GK R R GPRG GAR P +G+S G P PPG
Sbjct: 874 GANGEKGARGVAGKPGPRGQRG-----PTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPG 928
Query: 322 AEAVPEAAVLEVSEPPAEAVGEASG--SCPLRPGELRG-----------GGGGGQGAEGP 368
E P+ V P + G P PG+ RG G GG G +GP
Sbjct: 929 -ERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQ-RGETGFQGKTGPPGPGGVVGPQGP 986
Query: 369 PGTPRRTG-KGNRRKKRAAGRGAL--SRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKL 425
G G +G+ G L + G + A PG + + G P E L
Sbjct: 987 TGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGL 1046
Query: 426 PECHLVK-----EEYEGSGKPESEPKELKTAGEKEP-QLSEACGPT-------EEGA-GE 471
P E +G P P E +AG P L GP E+GA GE
Sbjct: 1047 PGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE 1106
Query: 472 RELEGPGLLCMAGHTGPEGPL 492
+ +GP AG G +GP+
Sbjct: 1107 KGPQGP-----AGRDGVQGPV 1122
Score = 52.0 bits (123), Expect = 4e-06
Identities = 93/379 (24%), Positives = 125/379 (32%), Gaps = 96/379 (25%)
Query: 203 PELPSGPPG---LPSPPLPEEALG----TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGS 255
P+ P GPPG LP P G T PG G +GP GE + E P
Sbjct: 944 PKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPG 1003
Query: 256 PTDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKGL----------------- 295
P +G PG + + P +G GK R + ++GL
Sbjct: 1004 PPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQG 1063
Query: 296 --GPRGQDGAR-------------------PPGEGSSTGA----SPESPPGAEAVPEAAV 330
GP G G R PPG GA P+ P G + V
Sbjct: 1064 PPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVG 1123
Query: 331 LEVSEPPAEAVGEASGSCPL-RPGELRGGGGGGQGAEGPPGTPRRTGK--------GNRR 381
L PA + GE + PG+ G G +G GPPG P G G+
Sbjct: 1124 LPGPAGPAGSPGEDGDKGEIGEPGQK--GSKGDKGENGPPGPPGLQGPVGAPGIAGGDGE 1181
Query: 382 KKRAAGRGALSRGGDSA----------------PLSPGDKEDASHQEALGNLPSPSEHKL 425
+G + GD P PG+K + +G P P +
Sbjct: 1182 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGP-PGPPGPRG 1240
Query: 426 PECHLVKEEYEGSGKPESEPKELKTAG----EKEPQLSEACGPTEEGA-----GERELEG 476
P + G+ P+ P + + G + EP + GP E GER +G
Sbjct: 1241 P------QGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKG 1294
Query: 477 -PGLLCMAGHTGPEGPLSD 494
G AG G +GP D
Sbjct: 1295 EAGPPGAAGPPGAKGPPGD 1313
Score = 51.2 bits (121), Expect = 7e-06
Identities = 66/227 (29%), Positives = 81/227 (35%), Gaps = 55/227 (24%)
Query: 197 QPSTLPPELPSGPPGLPSPPLPEEALGTR----SPGDGHNAPVEGPEGEYVELLEVTLPV 252
QP P +GPPG P P A G G A EGP G+ T PV
Sbjct: 1355 QPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGK-------TGPV 1407
Query: 253 RGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSS 311
P G PG +R +P G ++GL G GQDG PPG
Sbjct: 1408 --GPQGPAGKPGPEGLRGIPGPVG---------------EQGLPGAAGQDG--PPGP--- 1445
Query: 312 TGASPESPPGAEAVP-------EAAVLEVSEPPAEAVGEASGSCPLRPGE--LRGGGG-- 360
P PG + P ++ + PP E + P G +G GG
Sbjct: 1446 --MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIP 1503
Query: 361 ---GGQGAEGPPGTPRRTG-KGNRRKKRAAGRGALSRGGDSAPLSPG 403
G G GPPG P G KGN+ AG+ +G P PG
Sbjct: 1504 GPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQ----KGDSGLPGPPG 1546
Score = 50.1 bits (118), Expect = 2e-05
Identities = 97/358 (27%), Positives = 124/358 (34%), Gaps = 86/358 (24%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP------------------- 227
V + G++V P P GPPGL P P G R P
Sbjct: 445 VVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTM 504
Query: 228 --------GDGHNAP-VEGPEGEYVELL-EVTLPVRGSPTDAEGSPGLS-RVRTVPTRKG 276
GDG P + E + +L + + +RG P G GL+ R V
Sbjct: 505 LMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPP----GPMGLTGRPGPVGGPGS 560
Query: 277 AGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE---AVPEAAVLEV 333
+G KG GPRG G PPG G PGA+ +P
Sbjct: 561 SGAKGESG------DPGPQGPRGVQG--PPGPTGKPG--KRGRPGADGGRGMP------- 603
Query: 334 SEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGK-------GNRRKKRAA 386
EP A+ G P PG+ G G +G +GPPG P G G R A
Sbjct: 604 GEPGAKGDRGFDG-LPGLPGD--KGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEA 660
Query: 387 G-RGALS-RGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESE 444
G RG L RG AP PG + P P + P+ +G+ P+
Sbjct: 661 GPRGLLGPRGTPGAPGQPG-------MAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL 713
Query: 445 P---KELKTAGEKEPQ-------LSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPL 492
P + GEK PQ L A GP E + G L G GP+GP+
Sbjct: 714 PGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGAL---GPPGPQGPI 768
Score = 32.3 bits (72), Expect = 3.6
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Query: 195 GHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP-GDGHNAPVEGPEG 240
G P P P GPPGLP P P+ G+ P G ++ + GP G
Sbjct: 1500 GGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPG 1546
>gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo
sapiens]
Length = 1767
Score = 70.9 bits (172), Expect = 9e-12
Identities = 94/342 (27%), Positives = 120/342 (35%), Gaps = 53/342 (15%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGT-------------RSPGDGHNAPVEGPEGEYVE 244
P P P GP G P P ++G+ +PG A V GP+GE E
Sbjct: 1182 PGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGE 1241
Query: 245 LLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLG-PRGQDG- 302
E P P A+G PG + P G G Q G+G +G+DG
Sbjct: 1242 KGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGD 1301
Query: 303 -ARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGG 361
+P G S A P PPG P AA E + A GEA P PG + G G
Sbjct: 1302 PGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGP--PG--KTGPVG 1357
Query: 362 GQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPL----------SPGDKEDASHQ 411
QG G PG G ++ GA + G P+ PG K + H
Sbjct: 1358 PQGPAGKPGPEGLRGIPGPVGEQGL-PGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHP 1416
Query: 412 EALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGE 471
+G + P E + E G P ++ P + GP G
Sbjct: 1417 GLIGLIGPPGE---------QGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP----PGP 1463
Query: 472 RELEGP-GLLCMAGHTGPEGPLSD--------TPTPPLETVQ 504
L GP G G TGP G D +P PP E +Q
Sbjct: 1464 PGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQ 1505
Score = 59.3 bits (142), Expect = 3e-08
Identities = 96/350 (27%), Positives = 123/350 (35%), Gaps = 48/350 (13%)
Query: 198 PSTLP-PELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSP 256
P LP P+ P GPPG P G PG G EG+ E + P P
Sbjct: 659 PQGLPGPQGPIGPPGEKGPQGKPGLAGL--PGADGPPGHPGKEGQSGEKGALGPPGPQGP 716
Query: 257 TDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP 306
G G+ VR + KG G+ + M KG +GPRG+DG P
Sbjct: 717 IGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDG--PE 774
Query: 307 GEGSSTGASPESPPGAEAVPEAAVLEVSEP--PAEAVGEASGSCPLRPGELRGGGGGGQG 364
G G + + P +A + + P P + S P PG G G +G
Sbjct: 775 GPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGA--NGEKGARG 832
Query: 365 AEGPPGTPRRTGKGNRRKKRAAGRGALSR-------GGDSAPLSPGDKEDASHQEALGNL 417
G PG + G R R A RG + GGD P PG++ Q +G
Sbjct: 833 VAGKPGPRGQRGPTGPRGSRGA-RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVG-F 890
Query: 418 PSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTEEGA--GEREL 474
P P K P K+ G E G P + GPT E GER
Sbjct: 891 PGP---KGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGER-- 945
Query: 475 EGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHP 524
GH GP GP + P + KGD P+ +S D P
Sbjct: 946 ---------GHPGPPGPPGEQGLPGAAGKEGAKGDPGPQ---GISGKDGP 983
Score = 58.2 bits (139), Expect = 6e-08
Identities = 95/335 (28%), Positives = 114/335 (34%), Gaps = 62/335 (18%)
Query: 206 PSGPPGLPSPP-LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPG 264
P GPPGL P P A G PG + G +G+ RG P G G
Sbjct: 1109 PPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDE--------GARGFP-GPPGPIG 1159
Query: 265 LSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEA 324
L + P KG G +GP G G R P +G + P+ PPG+
Sbjct: 1160 LQGLPGPPGEKGENGD-----------VGPMGPPGPPGPRGP-QGPNGADGPQGPPGSVG 1207
Query: 325 VPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQ----GAEGPPGTPRRTG-KGN 379
V E EP GEA P PGE GG G+ G GPPG G KG
Sbjct: 1208 -SVGGVGEKGEP-----GEAGNPGP--PGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1259
Query: 380 RRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNL-----------PSPSEHKLPE 427
G G + GD P PG+ A G+ P PS P
Sbjct: 1260 PGDDGPKGNPGPVGFPGDPGP--PGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPP 1317
Query: 428 CHLVKEEYEGSGKPESEPKELKTAGEK----EPQLSEACGPTEEGA-----GERELEGP- 477
K G+ E E GE P + GP G R + GP
Sbjct: 1318 GPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV 1377
Query: 478 ---GLLCMAGHTGPEGPLSDTPTPPLETVQEGKGD 509
GL AG GP GP+ P L+ KG+
Sbjct: 1378 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGE 1412
Score = 56.2 bits (134), Expect = 2e-07
Identities = 93/321 (28%), Positives = 116/321 (36%), Gaps = 51/321 (15%)
Query: 208 GPPGLPSPPLPEEALG-TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
GP G P P+ G T PG A +G G V L P R P + G PG
Sbjct: 766 GPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLG--VPGLP-GYPGRQGPKGSTGFPGFP 822
Query: 267 RVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPG-----EGSSTGASPESPPG 321
+G GK R R GPRG GAR P +G+S G P PPG
Sbjct: 823 GANGEKGARGVAGKPGPRGQRG-----PTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPG 877
Query: 322 AEAVPEAAVLEVSEPPAEAVGEASG--SCPLRPGELRG-----------GGGGGQGAEGP 368
E P+ V P + G P PG+ RG G GG G +GP
Sbjct: 878 -ERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQ-RGETGFQGKTGPPGPGGVVGPQGP 935
Query: 369 PGTPRRTG-KGNRRKKRAAGRGAL--SRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKL 425
G G +G+ G L + G + A PG + + G P E L
Sbjct: 936 TGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGL 995
Query: 426 PECHLVK-----EEYEGSGKPESEPKELKTAGEKEP-QLSEACGPT-------EEGA-GE 471
P E +G P P E +AG P L GP E+GA GE
Sbjct: 996 PGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE 1055
Query: 472 RELEGPGLLCMAGHTGPEGPL 492
+ +GP AG G +GP+
Sbjct: 1056 KGPQGP-----AGRDGVQGPV 1071
Score = 52.0 bits (123), Expect = 4e-06
Identities = 93/379 (24%), Positives = 125/379 (32%), Gaps = 96/379 (25%)
Query: 203 PELPSGPPG---LPSPPLPEEALG----TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGS 255
P+ P GPPG LP P G T PG G +GP GE + E P
Sbjct: 893 PKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPG 952
Query: 256 PTDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKGL----------------- 295
P +G PG + + P +G GK R + ++GL
Sbjct: 953 PPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQG 1012
Query: 296 --GPRGQDGAR-------------------PPGEGSSTGA----SPESPPGAEAVPEAAV 330
GP G G R PPG GA P+ P G + V
Sbjct: 1013 PPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVG 1072
Query: 331 LEVSEPPAEAVGEASGSCPL-RPGELRGGGGGGQGAEGPPGTPRRTGK--------GNRR 381
L PA + GE + PG+ G G +G GPPG P G G+
Sbjct: 1073 LPGPAGPAGSPGEDGDKGEIGEPGQK--GSKGDKGENGPPGPPGLQGPVGAPGIAGGDGE 1130
Query: 382 KKRAAGRGALSRGGDSA----------------PLSPGDKEDASHQEALGNLPSPSEHKL 425
+G + GD P PG+K + +G P P +
Sbjct: 1131 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGP-PGPPGPRG 1189
Query: 426 PECHLVKEEYEGSGKPESEPKELKTAG----EKEPQLSEACGPTEEGA-----GERELEG 476
P + G+ P+ P + + G + EP + GP E GER +G
Sbjct: 1190 P------QGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKG 1243
Query: 477 -PGLLCMAGHTGPEGPLSD 494
G AG G +GP D
Sbjct: 1244 EAGPPGAAGPPGAKGPPGD 1262
Score = 51.2 bits (121), Expect = 7e-06
Identities = 66/227 (29%), Positives = 81/227 (35%), Gaps = 55/227 (24%)
Query: 197 QPSTLPPELPSGPPGLPSPPLPEEALGTR----SPGDGHNAPVEGPEGEYVELLEVTLPV 252
QP P +GPPG P P A G G A EGP G+ T PV
Sbjct: 1304 QPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGK-------TGPV 1356
Query: 253 RGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSS 311
P G PG +R +P G ++GL G GQDG PPG
Sbjct: 1357 --GPQGPAGKPGPEGLRGIPGPVG---------------EQGLPGAAGQDG--PPGP--- 1394
Query: 312 TGASPESPPGAEAVP-------EAAVLEVSEPPAEAVGEASGSCPLRPGE--LRGGGG-- 360
P PG + P ++ + PP E + P G +G GG
Sbjct: 1395 --MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIP 1452
Query: 361 ---GGQGAEGPPGTPRRTG-KGNRRKKRAAGRGALSRGGDSAPLSPG 403
G G GPPG P G KGN+ AG+ +G P PG
Sbjct: 1453 GPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQ----KGDSGLPGPPG 1495
Score = 50.1 bits (118), Expect = 2e-05
Identities = 97/358 (27%), Positives = 124/358 (34%), Gaps = 86/358 (24%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP------------------- 227
V + G++V P P GPPGL P P G R P
Sbjct: 394 VVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTM 453
Query: 228 --------GDGHNAP-VEGPEGEYVELL-EVTLPVRGSPTDAEGSPGLS-RVRTVPTRKG 276
GDG P + E + +L + + +RG P G GL+ R V
Sbjct: 454 LMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPP----GPMGLTGRPGPVGGPGS 509
Query: 277 AGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE---AVPEAAVLEV 333
+G KG GPRG G PPG G PGA+ +P
Sbjct: 510 SGAKGESG------DPGPQGPRGVQG--PPGPTGKPG--KRGRPGADGGRGMP------- 552
Query: 334 SEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGK-------GNRRKKRAA 386
EP A+ G P PG+ G G +G +GPPG P G G R A
Sbjct: 553 GEPGAKGDRGFDG-LPGLPGD--KGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEA 609
Query: 387 G-RGALS-RGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESE 444
G RG L RG AP PG + P P + P+ +G+ P+
Sbjct: 610 GPRGLLGPRGTPGAPGQPG-------MAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL 662
Query: 445 P---KELKTAGEKEPQ-------LSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPL 492
P + GEK PQ L A GP E + G L G GP+GP+
Sbjct: 663 PGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGAL---GPPGPQGPI 717
Score = 32.3 bits (72), Expect = 3.6
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Query: 195 GHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP-GDGHNAPVEGPEG 240
G P P P GPPGLP P P+ G+ P G ++ + GP G
Sbjct: 1449 GGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPG 1495
>gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo
sapiens]
Length = 1806
Score = 70.9 bits (172), Expect = 9e-12
Identities = 94/342 (27%), Positives = 120/342 (35%), Gaps = 53/342 (15%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGT-------------RSPGDGHNAPVEGPEGEYVE 244
P P P GP G P P ++G+ +PG A V GP+GE E
Sbjct: 1221 PGPPGPRGPQGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGE 1280
Query: 245 LLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLG-PRGQDG- 302
E P P A+G PG + P G G Q G+G +G+DG
Sbjct: 1281 KGEAGPPGAAGPPGAKGPPGDDGPKGNPGPVGFPGDPGPPGEPGPAGQDGVGGDKGEDGD 1340
Query: 303 -ARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGG 361
+P G S A P PPG P AA E + A GEA P PG + G G
Sbjct: 1341 PGQPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGP--PG--KTGPVG 1396
Query: 362 GQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPL----------SPGDKEDASHQ 411
QG G PG G ++ GA + G P+ PG K + H
Sbjct: 1397 PQGPAGKPGPEGLRGIPGPVGEQGL-PGAAGQDGPPGPMGPPGLPGLKGDPGSKGEKGHP 1455
Query: 412 EALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGE 471
+G + P E + E G P ++ P + GP G
Sbjct: 1456 GLIGLIGPPGE---------QGEKGDRGLPGTQGSPGAKGDGGIPGPAGPLGP----PGP 1502
Query: 472 RELEGP-GLLCMAGHTGPEGPLSD--------TPTPPLETVQ 504
L GP G G TGP G D +P PP E +Q
Sbjct: 1503 PGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPGSPGPPGEVIQ 1544
Score = 59.3 bits (142), Expect = 3e-08
Identities = 96/350 (27%), Positives = 123/350 (35%), Gaps = 48/350 (13%)
Query: 198 PSTLP-PELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSP 256
P LP P+ P GPPG P G PG G EG+ E + P P
Sbjct: 698 PQGLPGPQGPIGPPGEKGPQGKPGLAGL--PGADGPPGHPGKEGQSGEKGALGPPGPQGP 755
Query: 257 TDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP 306
G G+ VR + KG G+ + M KG +GPRG+DG P
Sbjct: 756 IGYPGPRGVKGADGVRGLKGSKGEKGEDGFPGFKGDMGLKGDRGEVGQIGPRGEDG--PE 813
Query: 307 GEGSSTGASPESPPGAEAVPEAAVLEVSEP--PAEAVGEASGSCPLRPGELRGGGGGGQG 364
G G + + P +A + + P P + S P PG G G +G
Sbjct: 814 GPKGRAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGA--NGEKGARG 871
Query: 365 AEGPPGTPRRTGKGNRRKKRAAGRGALSR-------GGDSAPLSPGDKEDASHQEALGNL 417
G PG + G R R A RG + GGD P PG++ Q +G
Sbjct: 872 VAGKPGPRGQRGPTGPRGSRGA-RGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVG-F 929
Query: 418 PSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTEEGA--GEREL 474
P P K P K+ G E G P + GPT E GER
Sbjct: 930 PGP---KGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGER-- 984
Query: 475 EGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHP 524
GH GP GP + P + KGD P+ +S D P
Sbjct: 985 ---------GHPGPPGPPGEQGLPGAAGKEGAKGDPGPQ---GISGKDGP 1022
Score = 58.2 bits (139), Expect = 6e-08
Identities = 95/335 (28%), Positives = 114/335 (34%), Gaps = 62/335 (18%)
Query: 206 PSGPPGLPSPP-LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPG 264
P GPPGL P P A G PG + G +G+ RG P G G
Sbjct: 1148 PPGPPGLQGPVGAPGIAGGDGEPGPRGQQGMFGQKGDE--------GARGFP-GPPGPIG 1198
Query: 265 LSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEA 324
L + P KG G +GP G G R P +G + P+ PPG+
Sbjct: 1199 LQGLPGPPGEKGENGD-----------VGPMGPPGPPGPRGP-QGPNGADGPQGPPGSVG 1246
Query: 325 VPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQ----GAEGPPGTPRRTG-KGN 379
V E EP GEA P PGE GG G+ G GPPG G KG
Sbjct: 1247 -SVGGVGEKGEP-----GEAGNPGP--PGEAGVGGPKGERGEKGEAGPPGAAGPPGAKGP 1298
Query: 380 RRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNL-----------PSPSEHKLPE 427
G G + GD P PG+ A G+ P PS P
Sbjct: 1299 PGDDGPKGNPGPVGFPGDPGP--PGEPGPAGQDGVGGDKGEDGDPGQPGPPGPSGEAGPP 1356
Query: 428 CHLVKEEYEGSGKPESEPKELKTAGEK----EPQLSEACGPTEEGA-----GERELEGP- 477
K G+ E E GE P + GP G R + GP
Sbjct: 1357 GPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGPAGKPGPEGLRGIPGPV 1416
Query: 478 ---GLLCMAGHTGPEGPLSDTPTPPLETVQEGKGD 509
GL AG GP GP+ P L+ KG+
Sbjct: 1417 GEQGLPGAAGQDGPPGPMGPPGLPGLKGDPGSKGE 1451
Score = 56.2 bits (134), Expect = 2e-07
Identities = 93/321 (28%), Positives = 116/321 (36%), Gaps = 51/321 (15%)
Query: 208 GPPGLPSPPLPEEALG-TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
GP G P P+ G T PG A +G G V L P R P + G PG
Sbjct: 805 GPRGEDGPEGPKGRAGPTGDPGPSGQAGEKGKLG--VPGLP-GYPGRQGPKGSTGFPGFP 861
Query: 267 RVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPG-----EGSSTGASPESPPG 321
+G GK R R GPRG GAR P +G+S G P PPG
Sbjct: 862 GANGEKGARGVAGKPGPRGQRG-----PTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPG 916
Query: 322 AEAVPEAAVLEVSEPPAEAVGEASG--SCPLRPGELRG-----------GGGGGQGAEGP 368
E P+ V P + G P PG+ RG G GG G +GP
Sbjct: 917 -ERGPQGPQGPVGFPGPKGPPGPPGKDGLPGHPGQ-RGETGFQGKTGPPGPGGVVGPQGP 974
Query: 369 PGTPRRTG-KGNRRKKRAAGRGAL--SRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKL 425
G G +G+ G L + G + A PG + + G P E L
Sbjct: 975 TGETGPIGERGHPGPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGL 1034
Query: 426 PECHLVK-----EEYEGSGKPESEPKELKTAGEKEP-QLSEACGPT-------EEGA-GE 471
P E +G P P E +AG P L GP E+GA GE
Sbjct: 1035 PGAQGAPGLKGGEGPQGPPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGE 1094
Query: 472 RELEGPGLLCMAGHTGPEGPL 492
+ +GP AG G +GP+
Sbjct: 1095 KGPQGP-----AGRDGVQGPV 1110
Score = 52.0 bits (123), Expect = 4e-06
Identities = 93/379 (24%), Positives = 125/379 (32%), Gaps = 96/379 (25%)
Query: 203 PELPSGPPG---LPSPPLPEEALG----TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGS 255
P+ P GPPG LP P G T PG G +GP GE + E P
Sbjct: 932 PKGPPGPPGKDGLPGHPGQRGETGFQGKTGPPGPGGVVGPQGPTGETGPIGERGHPGPPG 991
Query: 256 PTDAEGSPGLSR---VRTVPTRKGAGGKGRHRRHRAWMHQKGL----------------- 295
P +G PG + + P +G GK R + ++GL
Sbjct: 992 PPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGEGPQG 1051
Query: 296 --GPRGQDGAR-------------------PPGEGSSTGA----SPESPPGAEAVPEAAV 330
GP G G R PPG GA P+ P G + V
Sbjct: 1052 PPGPVGSPGERGSAGTAGPIGLPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGVQGPVG 1111
Query: 331 LEVSEPPAEAVGEASGSCPL-RPGELRGGGGGGQGAEGPPGTPRRTGK--------GNRR 381
L PA + GE + PG+ G G +G GPPG P G G+
Sbjct: 1112 LPGPAGPAGSPGEDGDKGEIGEPGQK--GSKGDKGENGPPGPPGLQGPVGAPGIAGGDGE 1169
Query: 382 KKRAAGRGALSRGGDSA----------------PLSPGDKEDASHQEALGNLPSPSEHKL 425
+G + GD P PG+K + +G P P +
Sbjct: 1170 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQGLPGPPGEKGENGDVGPMGP-PGPPGPRG 1228
Query: 426 PECHLVKEEYEGSGKPESEPKELKTAG----EKEPQLSEACGPTEEGA-----GERELEG 476
P + G+ P+ P + + G + EP + GP E GER +G
Sbjct: 1229 P------QGPNGADGPQGPPGSVGSVGGVGEKGEPGEAGNPGPPGEAGVGGPKGERGEKG 1282
Query: 477 -PGLLCMAGHTGPEGPLSD 494
G AG G +GP D
Sbjct: 1283 EAGPPGAAGPPGAKGPPGD 1301
Score = 51.2 bits (121), Expect = 7e-06
Identities = 66/227 (29%), Positives = 81/227 (35%), Gaps = 55/227 (24%)
Query: 197 QPSTLPPELPSGPPGLPSPPLPEEALGTR----SPGDGHNAPVEGPEGEYVELLEVTLPV 252
QP P +GPPG P P A G G A EGP G+ T PV
Sbjct: 1343 QPGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGK-------TGPV 1395
Query: 253 RGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSS 311
P G PG +R +P G ++GL G GQDG PPG
Sbjct: 1396 --GPQGPAGKPGPEGLRGIPGPVG---------------EQGLPGAAGQDG--PPGP--- 1433
Query: 312 TGASPESPPGAEAVP-------EAAVLEVSEPPAEAVGEASGSCPLRPGE--LRGGGG-- 360
P PG + P ++ + PP E + P G +G GG
Sbjct: 1434 --MGPPGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGTQGSPGAKGDGGIP 1491
Query: 361 ---GGQGAEGPPGTPRRTG-KGNRRKKRAAGRGALSRGGDSAPLSPG 403
G G GPPG P G KGN+ AG+ +G P PG
Sbjct: 1492 GPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQ----KGDSGLPGPPG 1534
Score = 50.1 bits (118), Expect = 2e-05
Identities = 97/358 (27%), Positives = 124/358 (34%), Gaps = 86/358 (24%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP------------------- 227
V + G++V P P GPPGL P P G R P
Sbjct: 433 VVEPGMLVEGPPGPAGPAGIMGPPGLQGPTGPPGDPGDRGPPGRPGLPGADGLPGPPGTM 492
Query: 228 --------GDGHNAP-VEGPEGEYVELL-EVTLPVRGSPTDAEGSPGLS-RVRTVPTRKG 276
GDG P + E + +L + + +RG P G GL+ R V
Sbjct: 493 LMLPFRYGGDGSKGPTISAQEAQAQAILQQARIALRGPP----GPMGLTGRPGPVGGPGS 548
Query: 277 AGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE---AVPEAAVLEV 333
+G KG GPRG G PPG G PGA+ +P
Sbjct: 549 SGAKGESG------DPGPQGPRGVQG--PPGPTGKPG--KRGRPGADGGRGMP------- 591
Query: 334 SEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGK-------GNRRKKRAA 386
EP A+ G P PG+ G G +G +GPPG P G G R A
Sbjct: 592 GEPGAKGDRGFDG-LPGLPGD--KGHRGERGPQGPPGPPGDDGMRGEDGEIGPRGLPGEA 648
Query: 387 G-RGALS-RGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESE 444
G RG L RG AP PG + P P + P+ +G+ P+
Sbjct: 649 GPRGLLGPRGTPGAPGQPG-------MAGVDGPPGPKGNMGPQGEPGPPGQQGNPGPQGL 701
Query: 445 P---KELKTAGEKEPQ-------LSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPL 492
P + GEK PQ L A GP E + G L G GP+GP+
Sbjct: 702 PGPQGPIGPPGEKGPQGKPGLAGLPGADGPPGHPGKEGQSGEKGAL---GPPGPQGPI 756
Score = 32.3 bits (72), Expect = 3.6
Identities = 18/47 (38%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Query: 195 GHQPSTLPPELPSGPPGLPSPPLPEEALGTRSP-GDGHNAPVEGPEG 240
G P P P GPPGLP P P+ G+ P G ++ + GP G
Sbjct: 1488 GGIPGPAGPLGPPGPPGLPGPQGPKGNKGSTGPAGQKGDSGLPGPPG 1534
>gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]
Length = 1745
Score = 66.2 bits (160), Expect = 2e-10
Identities = 93/335 (27%), Positives = 114/335 (34%), Gaps = 58/335 (17%)
Query: 202 PPELPS--GPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDA 259
PP P GP G P PP + A G R P +G +G VRG
Sbjct: 1098 PPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQ--KGDDG-----------VRGF-VGV 1143
Query: 260 EGSPGLSRVRTVPTRKG-AGGKGRHRRHRAWMHQKGLGPRGQDGAR-------PPG---- 307
G PGL + P KG G G H A + GP G +G PG
Sbjct: 1144 IGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGE 1203
Query: 308 EGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEG 367
+G A PPGA +P P +GE S P G G G +G
Sbjct: 1204 KGERGDAGDPGPPGAPGIPG---------PKGDIGEKGDSGP-------SGAAGPPGKKG 1247
Query: 368 PPGTPRRTGK----GNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALG-----NLP 418
PPG G G G +S G D +P GD D G P
Sbjct: 1248 PPGEDGAKGSVGPTGLPGDLGPPGDPGVS-GIDGSPGEKGDPGDVGGPGPPGASGEPGAP 1306
Query: 419 SPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGP- 477
P + P H+ +E EG + EP G P + G R + GP
Sbjct: 1307 GPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPV 1366
Query: 478 ---GLLCMAGHTGPEGPLSDTPTPPLETVQEGKGD 509
GLL G GP GPL + P L+ KG+
Sbjct: 1367 GEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGE 1401
Score = 53.9 bits (128), Expect = 1e-06
Identities = 81/301 (26%), Positives = 104/301 (34%), Gaps = 54/301 (17%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
P GP G P P LG PG GP GE + +V P +G G
Sbjct: 1047 PPGPTGKDGIPGPLGPLGP--PG------AAGPSGEEGDKGDVGAPGHKGSKGDKGDAG- 1097
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGAR----PPG-------EGSSTGA 314
P + G G H GP G DGA+ PPG +G
Sbjct: 1098 -----PPGQPGIRGPAGHP-----------GPPGADGAQGRRGPPGLFGQKGDDGVRGFV 1141
Query: 315 SPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG--GGQGAEGPPGTP 372
PPG + +P PP E GE + P G G G G+EG PG P
Sbjct: 1142 GVIGPPGLQGLPG--------PPGEK-GEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLP 1192
Query: 373 RRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALG--NLPSPSEHKLPECHL 430
G+ ++ A G AP PG K D + G P K P
Sbjct: 1193 GGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPP--- 1249
Query: 431 VKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEG 490
++ +GS P P +L G +P +S G E ++ GPG +G G G
Sbjct: 1250 GEDGAKGSVGPTGLPGDLGPPG--DPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPG 1307
Query: 491 P 491
P
Sbjct: 1308 P 1308
Score = 53.5 bits (127), Expect = 2e-06
Identities = 85/328 (25%), Positives = 112/328 (34%), Gaps = 57/328 (17%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDA--EGSP 263
P G PG+P P + LG GH EGP GE +G P A G P
Sbjct: 666 PPGNPGIPGLPGSDGPLGH----PGH----EGPTGEK--------GAQGPPGSAGPPGYP 709
Query: 264 GLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------------LGPRGQDGARPPGEGS 310
G V+ +G G+ + + KG GPRG+DG P +G
Sbjct: 710 GPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGPEGP-KGQ 768
Query: 311 STGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG-GGGGGQGAEGPP 369
+ A E PPG+ E L V P P RPG G G G G
Sbjct: 769 AGQAGEEGPPGSAG--EKGKLGVPGLPGY---------PGRPGPKGSIGFPGPLGPIGEK 817
Query: 370 GTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASH--------QEALGNLPSPS 421
G +TG+ +R RG A PG K D ++ L L P
Sbjct: 818 GKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPP 877
Query: 422 EHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLC 481
P+ + +G + EL G+ P GP + + G L
Sbjct: 878 GFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPP-----GPAGVLGPQGKTGEVGPLG 932
Query: 482 MAGHTGPEGPLSDTPTPPLETVQEGKGD 509
G GP GP + P LE + KG+
Sbjct: 933 ERGPPGPPGPPGEQGLPGLEGREGAKGE 960
Score = 53.1 bits (126), Expect = 2e-06
Identities = 100/365 (27%), Positives = 125/365 (34%), Gaps = 95/365 (26%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAP-VEGPEGEYVELLEVTLP----------VRG 254
P G GLP PP + +G H AP GP+G LP +G
Sbjct: 1146 PPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKG 1205
Query: 255 SPTDAEGSPGLSRVRTVPTRKG-AGGKGRHRRHRAWMHQKGLGPRGQDGAR--------- 304
DA G PG +P KG G KG A GP G+DGA+
Sbjct: 1206 ERGDA-GDPGPPGAPGIPGPKGDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLP 1264
Query: 305 ----PPGEGSSTGASPESPPGAEAVPEAAVLEVSEP-PAEAVGEASGSCPLRPG------ 353
PPG+ +G + PG + P +V P P A GE P PG
Sbjct: 1265 GDLGPPGDPGVSGI--DGSPGEKGDPG----DVGGPGPPGASGEPGAPGP--PGKRGPSG 1316
Query: 354 ----ELRGGGGGGQGAEGPPGTPRRTG-------------KGNRRKKRAAGR----GALS 392
E R G G +G GP G P RTG +G R G GA
Sbjct: 1317 HMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPG 1376
Query: 393 RGGDSAPLSP----------GDKEDASHQEALGNLPSPSE------HKLPECHLVKEEYE 436
+ G PL P G K + H +G + P E LP +
Sbjct: 1377 QMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGV-------Q 1429
Query: 437 GSGKPESEPKELKTAGEK-EPQLSEACGPTEEGAGERELEG-PGLLCMAGHTGPEGPLSD 494
G P+ +P G P GP G++ +G PG + G TGP GP
Sbjct: 1430 GPPGPKGDPGPPGPIGSLGHPGPPGVAGPL----GQKGSKGSPGSMGPRGDTGPAGP--- 1482
Query: 495 TPTPP 499
P PP
Sbjct: 1483 -PGPP 1486
Score = 50.4 bits (119), Expect = 1e-05
Identities = 89/321 (27%), Positives = 115/321 (35%), Gaps = 73/321 (22%)
Query: 208 GPPGLPSPPLPEEALGTRSP-GDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
G G P PP + G P G A GP G L RGSP G PG++
Sbjct: 569 GHVGQPGPPGEDGERGAEGPPGPTGQAGEPGPRG--------LLGPRGSPGPT-GRPGVT 619
Query: 267 RVRTVPTRKG-------AGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSSTGASPES 318
+ P KG G G+ H + +GL GP+G G PGE +
Sbjct: 620 GIDGAPGAKGNVGPPGEPGPPGQQGNHGS----QGLPGPQGLIGT--PGE--------KG 665
Query: 319 PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKG 378
PPG +P L S+ P G + GE G G G+ GPPG P G
Sbjct: 666 PPGNPGIPG---LPGSDGPLGHPGHEGPT-----GEK--GAQGPPGSAGPPGYP-----G 710
Query: 379 NRRKKRAAGRGAL--SRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYE 436
R K +G L +G PG K D + G +P
Sbjct: 711 PRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGP-------------R 757
Query: 437 GSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGER-ELEGPGLLCMAGHTGPEGPLSDT 495
G PE + AGE+ P S AGE+ +L PGL G GP+G +
Sbjct: 758 GEDGPEGPKGQAGQAGEEGPPGS---------AGEKGKLGVPGLPGYPGRPGPKGSIG-F 807
Query: 496 PTPPLETVQEGKGDNIPEEAL 516
P P ++GK + L
Sbjct: 808 PGPLGPIGEKGKSGKTGQPGL 828
Score = 49.7 bits (117), Expect = 2e-05
Identities = 93/354 (26%), Positives = 123/354 (34%), Gaps = 71/354 (20%)
Query: 203 PELPSGPPGLPSPPLPEEALGTRS-PG-DGHNAP---------------VEGPEGEYVE- 244
P P GPPG P P P G PG DG P +GP + +
Sbjct: 405 PSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQFAGGSFKGPPVSFQQA 464
Query: 245 -----LLEVTLPVRG--SPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG--- 294
L + L ++G P G PG + P KG G + R G
Sbjct: 465 QAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGAEGPQGPRGLQGPHGPPG 524
Query: 295 ----LGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPL 350
+G G DGAR G TG P+ G + +P + VG+ P
Sbjct: 525 RVGKMGRPGADGAR--GLPGDTG--PKGDRGFDGLPGLPGEKGQRGDFGHVGQ-----PG 575
Query: 351 RPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLS-PGDKEDAS 409
PGE G +GAEGPPG + G+ RG L G P PG
Sbjct: 576 PPGE-----DGERGAEGPPGPTGQAGE-------PGPRGLLGPRGSPGPTGRPGVTGIDG 623
Query: 410 HQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-------LSEAC 462
A GN+ P E P ++ GS + T GEK P L +
Sbjct: 624 APGAKGNVGPPGEPGPPG----QQGNHGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSD 679
Query: 463 GPT-----EEGAGERELEG-PGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDN 510
GP E GE+ +G PG G+ GP G + L+ + KG++
Sbjct: 680 GPLGHPGHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGED 733
Score = 40.0 bits (92), Expect = 0.017
Identities = 86/373 (23%), Positives = 114/373 (30%), Gaps = 105/373 (28%)
Query: 207 SGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
+G PGL P + G R P GP+G+ + +P +G PG
Sbjct: 823 TGQPGLEGERGPPGSRGERGQPGATGQP--GPKGDVGQDGAPGIPGEKGLPGLQGPPGFP 880
Query: 267 RVRTVPTRKGAGGKGRHRRHRAWMHQKG----------LGPRGQDG-ARPPGEGSSTGAS 315
+ P +G G+ H R + +G LGP+G+ G P GE G
Sbjct: 881 GPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGERGPPG-- 938
Query: 316 PESPPGAEAVP-----EAAVLEVSEP---------------------------------- 336
P PPG + +P E A E+ P
Sbjct: 939 PPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGLKGDKG 998
Query: 337 ---PAEAVGEASGSCPLRPGELRG-----------GGGGGQGAEGPPGTPRRTGKGNRRK 382
P A G PL P G G G +G+ G G P TGK
Sbjct: 999 PPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGPAGKKGSRGERGPPGPTGKD---- 1054
Query: 383 KRAAGRGALSRGGDSAPLSPGDKEDASHQEA-LGNLPSPSEHKLPECHLVKEEYEGSGKP 441
G PL P S +E G++ +P H + +G P
Sbjct: 1055 ---------GIPGPLGPLGPPGAAGPSGEEGDKGDVGAPG-------HKGSKGDKGDAGP 1098
Query: 442 ESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEG--------PLS 493
+P AG P P +GA R PGL G G G L
Sbjct: 1099 PGQPGIRGPAGHPGP-------PGADGAQGRR-GPPGLFGQKGDDGVRGFVGVIGPPGLQ 1150
Query: 494 DTPTPPLETVQEG 506
P PP E + G
Sbjct: 1151 GLPGPPGEKGEVG 1163
Score = 39.7 bits (91), Expect = 0.022
Identities = 61/213 (28%), Positives = 72/213 (33%), Gaps = 39/213 (18%)
Query: 203 PELPSGPPGLPSPPLPEEALGTRSPGDGHNAPV--EGPEGEYVELLEVTLPVRGSPTDAE 260
P SG PG P PP G R P GH EG +G E P R P A
Sbjct: 1296 PPGASGEPGAPGPP------GKRGPS-GHMGREGREGEKGAKGEPGPDGPPGRTGPMGAR 1348
Query: 261 GSPGL---SRVRTVPT---RKGAGGKGRHRRHRAWMHQKGL-------GPRGQDG----- 302
G PG +R +P G G + GL GP+G+ G
Sbjct: 1349 GPPGRVGPEGLRGIPGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLI 1408
Query: 303 --ARPPGEGSSTG----ASPESPPGAEAVP----EAAVLEVSEPPAEAVGEASGSCPLRP 352
PPGE G + PPG + P L PP A P
Sbjct: 1409 GLIGPPGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSP 1468
Query: 353 GELRGGGGGGQ-GAEGPPGTPRRTGKGNRRKKR 384
G + G G G GPPG P G RR++R
Sbjct: 1469 GSMGPRGDTGPAGPPGPPGAPAEL-HGLRRRRR 1500
Score = 35.0 bits (79), Expect = 0.55
Identities = 65/232 (28%), Positives = 83/232 (35%), Gaps = 53/232 (22%)
Query: 158 PTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPL 217
P GR+ P G++ +P V + GL+ P + P P GP GLP
Sbjct: 1350 PPGRVG------PEGLRGIPGP-------VGEPGLLGA--PGQMGPPGPLGPSGLPGLKG 1394
Query: 218 PEEALGTRSPGDGHNAPVE--GPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRK 275
G + GH + GP GE E + LP P +G PG P
Sbjct: 1395 DTGPKGEK----GHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGDPG------PPGPI 1444
Query: 276 GAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEA----------- 324
G+ G + QK G +G G+ P G + A P PPGA A
Sbjct: 1445 GSLGHPGPPGVAGPLGQK--GSKGSPGSMGP-RGDTGPAGPPGPPGAPAELHGLRRRRRF 1501
Query: 325 VPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTG 376
VP L V E E V + S L +LR PPGT R G
Sbjct: 1502 VP--VPLPVVEGGLEEVLASLTSLSLELEQLR----------RPPGTAERPG 1541
>gi|48762934 alpha 2 type I collagen [Homo sapiens]
Length = 1366
Score = 65.9 bits (159), Expect = 3e-10
Identities = 94/328 (28%), Positives = 119/328 (36%), Gaps = 53/328 (16%)
Query: 207 SGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVR--GSP-----TDA 259
+GPPG P P P+ +G + G+ A GP GE V L ++ PV G+P T A
Sbjct: 252 AGPPGFPGAPGPKGEIG--AVGNAGPAGPAGPRGE-VGLPGLSGPVGPPGNPGANGLTGA 308
Query: 260 EGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL----GPRGQDGARPPGEGSSTGAS 315
+G+ GL V P G G +GL GP G G +G A
Sbjct: 309 KGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKG-ESGNKGEPGSAG 367
Query: 316 PESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--------GGGGGQGAEG 367
P+ PPG E GEA + P P LRG G G G G
Sbjct: 368 PQGPPGPSG---------EEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMG 418
Query: 368 PPGTPRRTGK-GNRRKKRAAGRGALS--RGGDSAPLSPGDKEDASHQEALGNLPSPSEHK 424
PPG+ +G G R AGR G P SPG+ A + +G LP
Sbjct: 419 PPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVG-LPGIDGRP 477
Query: 425 LPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAG 484
P G EP + G K GPT + + GL G
Sbjct: 478 GPI---------GPAGARGEPGNIGFPGPK--------GPTGDPGKNGDKGHAGLAGARG 520
Query: 485 HTGPEGPLSDTPTPPLETVQEGKGDNIP 512
GP+G P + VQ GKG+ P
Sbjct: 521 APGPDGNNGAQGPPGPQGVQGGKGEQGP 548
Score = 64.3 bits (155), Expect = 9e-10
Identities = 100/351 (28%), Positives = 126/351 (35%), Gaps = 61/351 (17%)
Query: 203 PELPSGPPGLPSPPLPEEALGTR-SPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P+ P+G PG G R +PG N +GP G V+G + +G
Sbjct: 497 PKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQ--------GVQGGKGE-QG 547
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL----GPRGQDGARPPGEGSSTGAS-- 315
PG + +P G G+ R + GL GPRG+ G PPGE + G +
Sbjct: 548 PPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERG--PPGESGAAGPTGP 605
Query: 316 -----PESPPGAEAVPEAAVLEVSEPPAE-AVGEASGSCPLR-PGELRGGGG--GGQGAE 366
P PPG + EP AVG A S P PGE RG G GG+G +
Sbjct: 606 IGSRGPSGPPGPDG-------NKGEPGVVGAVGTAGPSGPSGLPGE-RGAAGIPGGKGEK 657
Query: 367 GPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLP 426
G PG G R R A + G A G+ A G SP E +
Sbjct: 658 GEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGE-RGE 716
Query: 427 ECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSE----------ACGPTEEG-----AGE 471
+ G +P G K P+ A GP AG
Sbjct: 717 VGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGS 776
Query: 472 RELEGP----GLLCMAGHTGPEGP--LSDTPTPPLETVQEG----KGDNIP 512
R GP G AG TGP GP +S P PP +EG +GD P
Sbjct: 777 RGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGP 827
Score = 53.1 bits (126), Expect = 2e-06
Identities = 66/233 (28%), Positives = 83/233 (35%), Gaps = 37/233 (15%)
Query: 203 PELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVE----------GPEGEYVELLEVTLP- 251
P P GP G P A+GT P P E G +GE E+ P
Sbjct: 611 PSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPG 670
Query: 252 ---VRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-LGPRGQDG-ARPP 306
RG+P A G+PG + GA G R ++G +GP G +G A P
Sbjct: 671 RDGARGAP-GAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPA 729
Query: 307 GEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG------ 360
G GA E GA+ + P A G A + P P RG GG
Sbjct: 730 GAAGQPGAKGER--GAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTG 787
Query: 361 -----------GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSP 402
G G GPPG P GK R R +G + R G+ + P
Sbjct: 788 FPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPR-GDQGPVGRTGEVGAVGP 839
Score = 52.8 bits (125), Expect = 3e-06
Identities = 90/331 (27%), Positives = 112/331 (33%), Gaps = 46/331 (13%)
Query: 190 EGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTR----SPGDGHNAPVEGPEGEYVEL 245
+G VG P + P GPPG P P+ G PG A GP G +
Sbjct: 82 DGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKA 141
Query: 246 LEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL----GPRGQD 301
E P + G G R P G G R H KG G +G+
Sbjct: 142 GEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEP 201
Query: 302 GARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGG 361
GA PGE + G + GA +P + PA A G P+ P G
Sbjct: 202 GA--PGENGTPGQT-----GARGLPGERGRVGAPGPAGARGSDGSVGPVGP-------AG 247
Query: 362 GQGAEGPPGTPRRTGK-------GNRRKKRAAG-RGALSRGGDSAPLSP----------G 403
G+ GPPG P G GN AG RG + G S P+ P G
Sbjct: 248 PIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTG 307
Query: 404 DKEDASHQEALG--NLPSPSEHKLPECHLVKEEYEG-SGKPESEPKELKTAGEKEPQLSE 460
K A G LP P P G G+P + ++ + EP +
Sbjct: 308 AKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAG 367
Query: 461 ACGPTEEGAGERELEGPGLLCMAGHTGPEGP 491
GP +GE GP AG GP GP
Sbjct: 368 PQGPPGP-SGEEGKRGPN--GEAGSAGPPGP 395
Score = 50.4 bits (119), Expect = 1e-05
Identities = 81/316 (25%), Positives = 100/316 (31%), Gaps = 53/316 (16%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPT 257
P P GPPG P +G+R P + GP+G E V P+
Sbjct: 582 PGPAGPRGERGPPGESGAAGPTGPIGSRGP-----SGPPGPDGNKGEPGVVGAVGTAGPS 636
Query: 258 DAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPE 317
G PG +P KG G+ R +G G+DGAR
Sbjct: 637 GPSGLPGERGAAGIPGGKGEKGEPGLRGE--------IGNPGRDGAR------------- 675
Query: 318 SPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPL-RPGELRG--GGGGGQGAEGPPGTPRR 374
PGA P A A A G A + P PGE RG G G G GP G +
Sbjct: 676 GAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGE-RGEVGPAGPNGFAGPAGAAGQ 734
Query: 375 TG-KGNRRKKRAAGR----------GALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEH 423
G KG R K G GA G + P P + P +
Sbjct: 735 PGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGR 794
Query: 424 KLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMA 483
P G P P G + P+ + GP + PG A
Sbjct: 795 TGP------PGPSGISGPPGPPGPAGKEGLRGPRGDQ--GPVGRTGEVGAVGPPG---FA 843
Query: 484 GHTGPEGPLSDTPTPP 499
G GP G + T PP
Sbjct: 844 GEKGPSGE-AGTAGPP 858
Score = 49.3 bits (116), Expect = 3e-05
Identities = 87/295 (29%), Positives = 104/295 (35%), Gaps = 65/295 (22%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
P+GPPG P PP P PG G N + +G+ V L G GL
Sbjct: 58 PTGPPGPPGPPGP--------PGLGGNFAAQ-YDGKGVGL-------------GPGPMGL 95
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAV 325
R P GA G Q GP G+ PGE TG P GA
Sbjct: 96 MGPRGPPGAAGAPGP-----------QGFQGPAGE-----PGEPGQTG-----PAGARG- 133
Query: 326 PEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTG-KGNRRKKR 384
+ PP +A + P RPGE G G QGA G PGTP G KG R
Sbjct: 134 -------PAGPPGKAGEDGHPGKPGRPGE--RGVVGPQGARGFPGTPGLPGFKGIRGHNG 184
Query: 385 AAGRGAL--SRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPE 442
G + G P +PG+ A G LP +GS P
Sbjct: 185 LDGLKGQPGAPGVKGEPGAPGENGTPGQTGARG-LPGERGRVGAPGPAGARGSDGSVGPV 243
Query: 443 SEPKELKTAGEKEPQLSEACGPTEE-----GAGERELEGP-GLLCMAGHTGPEGP 491
+ +AG P A GP E AG GP G + + G +GP GP
Sbjct: 244 GPAGPIGSAG--PPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGP 296
Score = 46.2 bits (108), Expect = 2e-04
Identities = 64/233 (27%), Positives = 78/233 (33%), Gaps = 24/233 (10%)
Query: 296 GPRGQDGAR-PPGEGSSTGAS-PESPPGAEAVPEAAVLEVSEPPAEAVGEASGSC----P 349
GPRG+ G PPG G + P PPG P ++ + VG G P
Sbjct: 39 GPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGP 98
Query: 350 LRPGELRGGGG--GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKED 407
P G G G QG G PG P +TG R A G P PG++
Sbjct: 99 RGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGV 158
Query: 408 ASHQEALG--NLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK-EPQLSEACG- 463
Q A G P K H + +G E GE P + A G
Sbjct: 159 VGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGL 218
Query: 464 PTEEG-------AGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGD 509
P E G AG R +G G GP GP+ P KG+
Sbjct: 219 PGERGRVGAPGPAGARGSDG-----SVGPVGPAGPIGSAGPPGFPGAPGPKGE 266
Score = 42.7 bits (99), Expect = 0.003
Identities = 88/342 (25%), Positives = 104/342 (30%), Gaps = 77/342 (22%)
Query: 208 GPPGLPSPPLPEEALGTRSP-GDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
G PG P P A G R G A GP G E EV P G G +
Sbjct: 676 GAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEV------GPAGPNGFAGPA 729
Query: 267 RVRTVPTRKGAGGKGRHRRHRAWMHQKG----LGPRGQDGARPPGEGSSTGASPESPPGA 322
P KG G + + G GP G +G PPG S G PPG
Sbjct: 730 GAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNG--PPGPAGSRGDG--GPPGM 785
Query: 323 EAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG------------------------- 357
P AA P+ G P LRG
Sbjct: 786 TGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGE 845
Query: 358 -GGGGGQGAEGPPGTPRRTG----------KGNRRKKRAAG-RGAL-------------S 392
G G G GPPGTP G G+R ++ G GA+ +
Sbjct: 846 KGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGA 905
Query: 393 RGGDSAPLSP---GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELK 449
RG A SP G +A GN P P H + Y G+ P +
Sbjct: 906 RGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPG-HKGERGYPGNIGP------VG 958
Query: 450 TAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGP 491
AG P GP + E G + AG GP GP
Sbjct: 959 AAGAPGPH--GPVGPAGKHGNRGETGPSGPVGPAGAVGPRGP 998
Score = 40.0 bits (92), Expect = 0.017
Identities = 50/187 (26%), Positives = 60/187 (32%), Gaps = 36/187 (19%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPT 257
P + P +G PG P P G R G + PV GP G P
Sbjct: 951 PGNIGPVGAAGAPGPHGPVGPAGKHGNRGE-TGPSGPV-GPAGAV------------GPR 996
Query: 258 DAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSSTGASP 316
G G+ + P KG G + H G+ G G GA GS A P
Sbjct: 997 GPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGA----PGSVGPAGP 1052
Query: 317 ESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG-----GGGGGQGAEGPPGT 371
P G PA G + P +RG G G G GPPG
Sbjct: 1053 RGPAGPSG------------PAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGP 1100
Query: 372 PRRTGKG 378
P +G G
Sbjct: 1101 PGVSGGG 1107
Score = 32.7 bits (73), Expect = 2.7
Identities = 38/163 (23%), Positives = 52/163 (31%), Gaps = 25/163 (15%)
Query: 358 GGGGGQGAEGPPGTPRRTGK----------GNRRKKRAAGRGALSRGGDSAPLSPGDKED 407
G G +G GPPG P R G+ G G A G L PG
Sbjct: 36 GDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGL 95
Query: 408 ASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEE 467
+ G +P + ++G EP + AG + P GP +
Sbjct: 96 MGPRGPPGAAGAPG----------PQGFQGPAGEPGEPGQTGPAGARGP-----AGPPGK 140
Query: 468 GAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKGDN 510
+ PG G GP+G TP L + +G N
Sbjct: 141 AGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHN 183
>gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein [Homo
sapiens]
Length = 1650
Score = 65.5 bits (158), Expect = 4e-10
Identities = 108/379 (28%), Positives = 129/379 (34%), Gaps = 34/379 (8%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
P GPPG P P P A G + G P+ GP G V LP P G G
Sbjct: 942 PIGPPGRPGPQGPPGAAGEKGV-PGEKGPI-GPTGRDGVQGPVGLPGPAGPPGVAGEDGD 999
Query: 266 SRVRTVPTRKGA-GGKGRHRRHR-----AWMHQKG-LGPRGQDGARPPGEGSSTGASPES 318
P +KG G KG H + Q G G G+ GAR P +G E
Sbjct: 1000 KGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGP-QGHFGAKGDEG 1058
Query: 319 PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG 376
G P L+ P+ GE P+ P G G G GA+GP G P G
Sbjct: 1059 TRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPP--GG 1116
Query: 377 KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYE 436
GN G S G PG K + G P E P +
Sbjct: 1117 VGNLGPPGEKGEPGES-GSPGIQGEPGVKGPRGERGEKGESGQPGEPGPPG----PKGPT 1171
Query: 437 GSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEG----PGLLCMAGHTGPEGP 491
G P+ P + G+ P E ++GA G+R +G PG G GP GP
Sbjct: 1172 GDDGPKGNPGPVGFPGDPGPP-GEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGP 1230
Query: 492 L---SDTPTPPLETVQEGKGDNIPEEALAVSVSDHP----DVAWDLMASGFLILTGGVDQ 544
L +P E Q GKG A+ P A G L G V Q
Sbjct: 1231 LGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQ 1290
Query: 545 SGRALLT--ITPPCPPEEP 561
GR T PP P P
Sbjct: 1291 QGRPGATGQAGPPGPVGPP 1309
Score = 58.9 bits (141), Expect = 4e-08
Identities = 99/357 (27%), Positives = 122/357 (34%), Gaps = 83/357 (23%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALG-------------TRSPGDGHNAPVEGPEGEYVE 244
P P P+GP G P P +G + SPG V+GP GE E
Sbjct: 1093 PGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGE 1152
Query: 245 LLEVTLPVR------GSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPR 298
E P PT +G G P G G+G GPR
Sbjct: 1153 KGESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEG--------------GPR 1198
Query: 299 GQDGAR-------PPGEGSSTGASPES-PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPL 350
GQDGA+ PG+ S G + E+ PPG A SE G A G
Sbjct: 1199 GQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG-AKGD--- 1254
Query: 351 RPGELRGGGGGGQ-GAEGPPGTPRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSP----- 402
PG + G G G GP G P G +G GR GA + G P+ P
Sbjct: 1255 -PGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPG 1313
Query: 403 -----GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK-EP 456
G K + H +G + P E +G P + G+K E
Sbjct: 1314 LRGDAGAKGEKGHPGLIGLIGPPGE-------------QGEKGDRGLPGPQGSPGQKGEM 1360
Query: 457 QLSEACGPTEEGAGERELEGP-GLLCMAGHTGPEGPLSDT--------PTPPLETVQ 504
+ A GP G G L GP G G TGP GP + P PP E +Q
Sbjct: 1361 GIPGASGPIGPG-GPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQ 1416
Score = 50.8 bits (120), Expect = 1e-05
Identities = 86/305 (28%), Positives = 107/305 (35%), Gaps = 41/305 (13%)
Query: 207 SGPPGLPSPPLPEEALGTR-SPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
SGP G P P G R + G G +G + E LP P G PG
Sbjct: 748 SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLP---GPQGPNGFPGP 804
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP-GEGSSTGASPE 317
P + G G R + + G +GP+G G P GE G P
Sbjct: 805 KGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPG--PP 862
Query: 318 SPPGAEAVPEAAVLEVS--EPPAEAVGEASGSCPLR--PGELRG-----GGGGGQGAEGP 368
PPG + +P A E + +P G LR PGE RG GG G +G EGP
Sbjct: 863 GPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE-RGLPGTAGGPGLKGNEGP 921
Query: 369 PGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPEC 428
G P G RGA GG P PG A G P E K P
Sbjct: 922 SGPPGPAGSPGE-------RGAAGSGGPIGP--PGRPGPQGPPGAAGEKGVPGE-KGPIG 971
Query: 429 HLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEGPGLLCMAGHTG 487
++ +G AGE + E P ++G G + GP G G
Sbjct: 972 PTGRDGVQGPVGLPGPAGPPGVAGE-DGDKGEVGDPGQKGTKGNKGEHGP-----PGPPG 1025
Query: 488 PEGPL 492
P GP+
Sbjct: 1026 PIGPV 1030
Score = 49.3 bits (116), Expect = 3e-05
Identities = 82/326 (25%), Positives = 109/326 (33%), Gaps = 41/326 (12%)
Query: 206 PSGPPGLPSPPLPEEALGTRS----PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P G PGLP P + G PG N GP+G G P G
Sbjct: 588 PQGKPGLPGMPGSDGPPGHPGKEGPPGTKGNQGPSGPQGPL-----------GYP-GPRG 635
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPPGEGSSTGA 314
G+ +R + KG G+ + + KG G RG+DG P G TG
Sbjct: 636 VKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDG--PEGPKGRTGP 693
Query: 315 SPE-SPPGAEAVP-EAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGG-QGAEGPPGT 371
+ + PPG + V + P + S P PG G G G GP G
Sbjct: 694 TGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGE 753
Query: 372 PRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECH 429
TG +G R + A G+ GA G P P + + P P P
Sbjct: 754 RGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGK 813
Query: 430 LVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPE 489
+G + E+ G+ P + AGE G + GH GP
Sbjct: 814 ------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGET-----GPMGERGHPGPP 862
Query: 490 GPLSDTPTPPLETVQEGKGDNIPEEA 515
GP + P + KGD P A
Sbjct: 863 GPPGEQGLPGTAGKEGTKGDPGPPGA 888
Score = 48.5 bits (114), Expect = 5e-05
Identities = 91/327 (27%), Positives = 111/327 (33%), Gaps = 82/327 (25%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELL 246
V + G++V P P GPPG+ P P G R P A + G +G
Sbjct: 304 VLEPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPG--RAGLPGSDG------ 355
Query: 247 EVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG-----RHRRHRAWMHQKGLGPRGQD 301
A G PG S + G G KG + + +A + Q L RG
Sbjct: 356 ------------APGPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRG-- 401
Query: 302 GARPPGEGSSTG-ASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 360
PPG TG P PG+ PG L+G G
Sbjct: 402 ---PPGPMGYTGRPGPLGQPGS-----------------------------PG-LKGESG 428
Query: 361 --GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLP 418
G QG GP G GK RR RA GA GD PG K D + L LP
Sbjct: 429 DLGPQGPRGPQGLTGPPGKAGRR-GRAGADGARGMPGD-----PGVKGDRGF-DGLPGLP 481
Query: 419 SPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTE--EGAGERELE 475
H+ +G P E E GE P+ L GP G +
Sbjct: 482 GEKGHR------GDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIP 535
Query: 476 G-PGLLCMAGHTGPEGPL--SDTPTPP 499
G PG+ M G GP+G L P PP
Sbjct: 536 GPPGVRGMDGPQGPKGSLGPQGEPGPP 562
Score = 48.1 bits (113), Expect = 6e-05
Identities = 85/322 (26%), Positives = 113/322 (35%), Gaps = 52/322 (16%)
Query: 206 PSGPPG---LPSPPLPEEALGTRS-PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P GPPG LP P P G + PG + G G+ E + +G T G
Sbjct: 783 PHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGE-----VGFQGK-TGPPG 836
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGAR----PPGEGSSTG-AS 315
PG+ + G G+ H ++GL G G++G + PPG G A
Sbjct: 837 PPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAG 896
Query: 316 PESPPGAEAVPEAA---VLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTP 372
PG +P A L+ +E P+ G A PGE RG G G G GPPG P
Sbjct: 897 LRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGS-----PGE-RGAAGSG-GPIGPPGRP 949
Query: 373 RRTG-KGNRRKKRAAGR----GALSRGGDSAPL-------------SPGDKEDASHQEAL 414
G G +K G G R G P+ GDK +
Sbjct: 950 GPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQK 1009
Query: 415 GNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGEREL 474
G + EH P G P +P GE + + + G R
Sbjct: 1010 GTKGNKGEHGPP-------GPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGF 1062
Query: 475 EG-PGLLCMAGHTGPEGPLSDT 495
G PG + + G GP G +T
Sbjct: 1063 NGPPGPIGLQGLPGPSGEKGET 1084
Score = 45.1 bits (105), Expect = 5e-04
Identities = 87/313 (27%), Positives = 109/313 (34%), Gaps = 67/313 (21%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVE--GPEGEYVELLEVTLPVRGSPTDAEGSP 263
P GPPG+P PP G R DG P GP+GE P +G+P
Sbjct: 528 PKGPPGIPGPP------GVRGM-DGPQGPKGSLGPQGE------------PGPPGQQGTP 568
Query: 264 GLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE 323
G + +P +GA G + GP+G+ G PG S G P PG E
Sbjct: 569 G---TQGLPGPQGAIGPHGEK-----------GPQGKPGL--PGMPGSDG--PPGHPGKE 610
Query: 324 AVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG-KGNR 380
P + P +G +RG G G +G +G PG G KG+R
Sbjct: 611 GPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDR 670
Query: 381 RKKRAAG-RGALSRGGDSAPLSP-GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGS 438
+ G RG G P GD G L P LP Y G
Sbjct: 671 GEVGVPGSRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPG---LP-------GYPGR 720
Query: 439 GKPESE---PKELKTAGEKEPQ-LSEACGPTEE--GAGERELEGP-------GLLCMAGH 485
P+ P +GEK + LS GP E G R GP G +G
Sbjct: 721 QGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGG 780
Query: 486 TGPEGPLSDTPTP 498
GP GP + P
Sbjct: 781 DGPHGPPGERGLP 793
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/91 (31%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGTRSPG-----DGHNAPV--EGPEGEYVELLEVTL 250
P P P GPPGLP P P+ A G PG G P GP GE ++ L + +
Sbjct: 1363 PGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQM 1422
Query: 251 PVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG 281
P + + +GS + +PT G G
Sbjct: 1423 P-KKTRRSVDGSRLMQEDEAIPTGGAPGSPG 1452
Score = 42.7 bits (99), Expect = 0.003
Identities = 64/242 (26%), Positives = 86/242 (35%), Gaps = 53/242 (21%)
Query: 198 PSTLPPELPSGPPGLPSPP----LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLP-V 252
P P P+GP G P P LP PG A GP G LP +
Sbjct: 1261 PGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGP------PGLPGL 1314
Query: 253 RGSP--TDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEG 309
RG +G PGL + P +G G +GL GP+G G + GE
Sbjct: 1315 RGDAGAKGEKGHPGLIGLIGPPGEQGEKG------------DRGLPGPQGSPGQK--GEM 1360
Query: 310 SSTGAS-PESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGP 368
GAS P P G +P PA G + P GG G +G +GP
Sbjct: 1361 GIPGASGPIGPGGPPGLPG---------PAGPKGAKGATGP-------GGPKGEKGVQGP 1404
Query: 369 PGTPRRTG--------KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 420
PG P G + ++ +R+ L + ++ P +E G+L S
Sbjct: 1405 PGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1464
Query: 421 SE 422
E
Sbjct: 1465 RE 1466
Score = 38.5 bits (88), Expect = 0.050
Identities = 53/215 (24%), Positives = 73/215 (33%), Gaps = 37/215 (17%)
Query: 155 KDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPS 214
K P G P G++ LP + V ++G G PP P GPPGLP
Sbjct: 1263 KTGPVGPAGPAGKPGPDGLRGLPGS-------VGQQG-RPGATGQAGPPG-PVGPPGLPG 1313
Query: 215 PPLPEEALGTRS-------------PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
A G + G+ + + GP+G + E+ +P P G
Sbjct: 1314 LRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGG 1373
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGAR-PPGEGSSTGASPESPP 320
PGL KGA G G GP+G+ G + PPG G + P
Sbjct: 1374 PPGLPGPAGPKGAKGATGPG--------------GPKGEKGVQGPPGHPGPPGEVIQPLP 1419
Query: 321 GAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGEL 355
++ S E +G P PG L
Sbjct: 1420 IQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGL 1454
Score = 36.6 bits (83), Expect = 0.19
Identities = 36/133 (27%), Positives = 50/133 (37%), Gaps = 9/133 (6%)
Query: 279 GKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVL----EVS 334
G R R H+ P+ Q + + +P E + E+++L E +
Sbjct: 230 GGQRERPQNQQPHRAQRSPQQQPSRLHRPQNQEPQSQDPTPGEEEEILESSLLPPLEEAA 289
Query: 335 EPPAEAVGEASGSCPLRPGELRGGGGGGQGAE---GPPGTPRRTGK-GNRRKKRAAGRGA 390
P GE L PG L G G +G GPPG G G+ ++ GR
Sbjct: 290 HGPRGLKGEKGEPAVLEPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPGRAG 349
Query: 391 LSRGGDSAPLSPG 403
L G D AP PG
Sbjct: 350 LP-GSDGAPGPPG 361
>gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein [Homo
sapiens]
Length = 1629
Score = 65.5 bits (158), Expect = 4e-10
Identities = 108/379 (28%), Positives = 129/379 (34%), Gaps = 34/379 (8%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
P GPPG P P P A G + G P+ GP G V LP P G G
Sbjct: 921 PIGPPGRPGPQGPPGAAGEKGV-PGEKGPI-GPTGRDGVQGPVGLPGPAGPPGVAGEDGD 978
Query: 266 SRVRTVPTRKGA-GGKGRHRRHR-----AWMHQKG-LGPRGQDGARPPGEGSSTGASPES 318
P +KG G KG H + Q G G G+ GAR P +G E
Sbjct: 979 KGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGP-QGHFGAKGDEG 1037
Query: 319 PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG 376
G P L+ P+ GE P+ P G G G GA+GP G P G
Sbjct: 1038 TRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPP--GG 1095
Query: 377 KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYE 436
GN G S G PG K + G P E P +
Sbjct: 1096 VGNLGPPGEKGEPGES-GSPGIQGEPGVKGPRGERGEKGESGQPGEPGPPG----PKGPT 1150
Query: 437 GSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEG----PGLLCMAGHTGPEGP 491
G P+ P + G+ P E ++GA G+R +G PG G GP GP
Sbjct: 1151 GDDGPKGNPGPVGFPGDPGPP-GEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGP 1209
Query: 492 L---SDTPTPPLETVQEGKGDNIPEEALAVSVSDHP----DVAWDLMASGFLILTGGVDQ 544
L +P E Q GKG A+ P A G L G V Q
Sbjct: 1210 LGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQ 1269
Query: 545 SGRALLT--ITPPCPPEEP 561
GR T PP P P
Sbjct: 1270 QGRPGATGQAGPPGPVGPP 1288
Score = 58.9 bits (141), Expect = 4e-08
Identities = 99/357 (27%), Positives = 122/357 (34%), Gaps = 83/357 (23%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALG-------------TRSPGDGHNAPVEGPEGEYVE 244
P P P+GP G P P +G + SPG V+GP GE E
Sbjct: 1072 PGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGE 1131
Query: 245 LLEVTLPVR------GSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPR 298
E P PT +G G P G G+G GPR
Sbjct: 1132 KGESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEG--------------GPR 1177
Query: 299 GQDGAR-------PPGEGSSTGASPES-PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPL 350
GQDGA+ PG+ S G + E+ PPG A SE G A G
Sbjct: 1178 GQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG-AKGD--- 1233
Query: 351 RPGELRGGGGGGQ-GAEGPPGTPRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSP----- 402
PG + G G G GP G P G +G GR GA + G P+ P
Sbjct: 1234 -PGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPG 1292
Query: 403 -----GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK-EP 456
G K + H +G + P E +G P + G+K E
Sbjct: 1293 LRGDAGAKGEKGHPGLIGLIGPPGE-------------QGEKGDRGLPGPQGSPGQKGEM 1339
Query: 457 QLSEACGPTEEGAGERELEGP-GLLCMAGHTGPEGPLSDT--------PTPPLETVQ 504
+ A GP G G L GP G G TGP GP + P PP E +Q
Sbjct: 1340 GIPGASGPIGPG-GPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQ 1395
Score = 50.8 bits (120), Expect = 1e-05
Identities = 86/305 (28%), Positives = 107/305 (35%), Gaps = 41/305 (13%)
Query: 207 SGPPGLPSPPLPEEALGTR-SPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
SGP G P P G R + G G +G + E LP P G PG
Sbjct: 727 SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLP---GPQGPNGFPGP 783
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP-GEGSSTGASPE 317
P + G G R + + G +GP+G G P GE G P
Sbjct: 784 KGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPG--PP 841
Query: 318 SPPGAEAVPEAAVLEVS--EPPAEAVGEASGSCPLR--PGELRG-----GGGGGQGAEGP 368
PPG + +P A E + +P G LR PGE RG GG G +G EGP
Sbjct: 842 GPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE-RGLPGTAGGPGLKGNEGP 900
Query: 369 PGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPEC 428
G P G RGA GG P PG A G P E K P
Sbjct: 901 SGPPGPAGSPGE-------RGAAGSGGPIGP--PGRPGPQGPPGAAGEKGVPGE-KGPIG 950
Query: 429 HLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEGPGLLCMAGHTG 487
++ +G AGE + E P ++G G + GP G G
Sbjct: 951 PTGRDGVQGPVGLPGPAGPPGVAGE-DGDKGEVGDPGQKGTKGNKGEHGP-----PGPPG 1004
Query: 488 PEGPL 492
P GP+
Sbjct: 1005 PIGPV 1009
Score = 49.3 bits (116), Expect = 3e-05
Identities = 82/326 (25%), Positives = 109/326 (33%), Gaps = 41/326 (12%)
Query: 206 PSGPPGLPSPPLPEEALGTRS----PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P G PGLP P + G PG N GP+G G P G
Sbjct: 567 PQGKPGLPGMPGSDGPPGHPGKEGPPGTKGNQGPSGPQGPL-----------GYP-GPRG 614
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPPGEGSSTGA 314
G+ +R + KG G+ + + KG G RG+DG P G TG
Sbjct: 615 VKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDG--PEGPKGRTGP 672
Query: 315 SPE-SPPGAEAVP-EAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGG-QGAEGPPGT 371
+ + PPG + V + P + S P PG G G G GP G
Sbjct: 673 TGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGE 732
Query: 372 PRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECH 429
TG +G R + A G+ GA G P P + + P P P
Sbjct: 733 RGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGK 792
Query: 430 LVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPE 489
+G + E+ G+ P + AGE G + GH GP
Sbjct: 793 ------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGET-----GPMGERGHPGPP 841
Query: 490 GPLSDTPTPPLETVQEGKGDNIPEEA 515
GP + P + KGD P A
Sbjct: 842 GPPGEQGLPGTAGKEGTKGDPGPPGA 867
Score = 48.5 bits (114), Expect = 5e-05
Identities = 91/327 (27%), Positives = 111/327 (33%), Gaps = 82/327 (25%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELL 246
V + G++V P P GPPG+ P P G R P A + G +G
Sbjct: 283 VLEPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPG--RAGLPGSDG------ 334
Query: 247 EVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG-----RHRRHRAWMHQKGLGPRGQD 301
A G PG S + G G KG + + +A + Q L RG
Sbjct: 335 ------------APGPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRG-- 380
Query: 302 GARPPGEGSSTG-ASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 360
PPG TG P PG+ PG L+G G
Sbjct: 381 ---PPGPMGYTGRPGPLGQPGS-----------------------------PG-LKGESG 407
Query: 361 --GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLP 418
G QG GP G GK RR RA GA GD PG K D + L LP
Sbjct: 408 DLGPQGPRGPQGLTGPPGKAGRR-GRAGADGARGMPGD-----PGVKGDRGF-DGLPGLP 460
Query: 419 SPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTE--EGAGERELE 475
H+ +G P E E GE P+ L GP G +
Sbjct: 461 GEKGHR------GDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIP 514
Query: 476 G-PGLLCMAGHTGPEGPL--SDTPTPP 499
G PG+ M G GP+G L P PP
Sbjct: 515 GPPGVRGMDGPQGPKGSLGPQGEPGPP 541
Score = 48.1 bits (113), Expect = 6e-05
Identities = 85/322 (26%), Positives = 113/322 (35%), Gaps = 52/322 (16%)
Query: 206 PSGPPG---LPSPPLPEEALGTRS-PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P GPPG LP P P G + PG + G G+ E + +G T G
Sbjct: 762 PHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGE-----VGFQGK-TGPPG 815
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGAR----PPGEGSSTG-AS 315
PG+ + G G+ H ++GL G G++G + PPG G A
Sbjct: 816 PPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAG 875
Query: 316 PESPPGAEAVPEAA---VLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTP 372
PG +P A L+ +E P+ G A PGE RG G G G GPPG P
Sbjct: 876 LRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGS-----PGE-RGAAGSG-GPIGPPGRP 928
Query: 373 RRTG-KGNRRKKRAAGR----GALSRGGDSAPL-------------SPGDKEDASHQEAL 414
G G +K G G R G P+ GDK +
Sbjct: 929 GPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQK 988
Query: 415 GNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGEREL 474
G + EH P G P +P GE + + + G R
Sbjct: 989 GTKGNKGEHGPP-------GPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGF 1041
Query: 475 EG-PGLLCMAGHTGPEGPLSDT 495
G PG + + G GP G +T
Sbjct: 1042 NGPPGPIGLQGLPGPSGEKGET 1063
Score = 45.1 bits (105), Expect = 5e-04
Identities = 87/313 (27%), Positives = 109/313 (34%), Gaps = 67/313 (21%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVE--GPEGEYVELLEVTLPVRGSPTDAEGSP 263
P GPPG+P PP G R DG P GP+GE P +G+P
Sbjct: 507 PKGPPGIPGPP------GVRGM-DGPQGPKGSLGPQGE------------PGPPGQQGTP 547
Query: 264 GLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE 323
G + +P +GA G + GP+G+ G PG S G P PG E
Sbjct: 548 G---TQGLPGPQGAIGPHGEK-----------GPQGKPGL--PGMPGSDG--PPGHPGKE 589
Query: 324 AVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG-KGNR 380
P + P +G +RG G G +G +G PG G KG+R
Sbjct: 590 GPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDR 649
Query: 381 RKKRAAG-RGALSRGGDSAPLSP-GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGS 438
+ G RG G P GD G L P LP Y G
Sbjct: 650 GEVGVPGSRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPG---LP-------GYPGR 699
Query: 439 GKPESE---PKELKTAGEKEPQ-LSEACGPTEE--GAGERELEGP-------GLLCMAGH 485
P+ P +GEK + LS GP E G R GP G +G
Sbjct: 700 QGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGG 759
Query: 486 TGPEGPLSDTPTP 498
GP GP + P
Sbjct: 760 DGPHGPPGERGLP 772
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/91 (31%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGTRSPG-----DGHNAPV--EGPEGEYVELLEVTL 250
P P P GPPGLP P P+ A G PG G P GP GE ++ L + +
Sbjct: 1342 PGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQM 1401
Query: 251 PVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG 281
P + + +GS + +PT G G
Sbjct: 1402 P-KKTRRSVDGSRLMQEDEAIPTGGAPGSPG 1431
Score = 42.7 bits (99), Expect = 0.003
Identities = 64/242 (26%), Positives = 86/242 (35%), Gaps = 53/242 (21%)
Query: 198 PSTLPPELPSGPPGLPSPP----LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLP-V 252
P P P+GP G P P LP PG A GP G LP +
Sbjct: 1240 PGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGP------PGLPGL 1293
Query: 253 RGSP--TDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEG 309
RG +G PGL + P +G G +GL GP+G G + GE
Sbjct: 1294 RGDAGAKGEKGHPGLIGLIGPPGEQGEKG------------DRGLPGPQGSPGQK--GEM 1339
Query: 310 SSTGAS-PESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGP 368
GAS P P G +P PA G + P GG G +G +GP
Sbjct: 1340 GIPGASGPIGPGGPPGLPG---------PAGPKGAKGATGP-------GGPKGEKGVQGP 1383
Query: 369 PGTPRRTG--------KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 420
PG P G + ++ +R+ L + ++ P +E G+L S
Sbjct: 1384 PGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1443
Query: 421 SE 422
E
Sbjct: 1444 RE 1445
Score = 39.3 bits (90), Expect = 0.029
Identities = 68/253 (26%), Positives = 84/253 (33%), Gaps = 51/253 (20%)
Query: 292 QKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLR 351
Q GPRG G + G E PPG PE + P + G R
Sbjct: 266 QAAHGPRGLKGEKGEPAVLEPGMLVEGPPG----PEGPAGLIGPPGIQGNPGPVGDPGER 321
Query: 352 PGELRGGGGGGQGAEGPPGT----PRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKED 407
R G G GA GPPGT P R G G GGD P+ +
Sbjct: 322 GPPGRAGLPGSDGAPGPPGTSLMLPFRFGSG---------------GGDKGPVVAAQEAQ 366
Query: 408 A-----SHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEA 461
A + AL P P + L + GS + E +L G + PQ L+
Sbjct: 367 AQAILQQARLALRGPPGPMGYTGRPGPLGQ---PGSPGLKGESGDLGPQGPRGPQGLTGP 423
Query: 462 CG----------------PTEEGA-GERELEG-PGLLCMAGHTGPEGPLSDTPTPPLETV 503
G P + G G+R +G PGL GH G G P PP E
Sbjct: 424 PGKAGRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTG-AQGLPGPPGEDG 482
Query: 504 QEGKGDNIPEEAL 516
+ G I L
Sbjct: 483 ERGDDGEIGPRGL 495
Score = 38.5 bits (88), Expect = 0.050
Identities = 53/215 (24%), Positives = 73/215 (33%), Gaps = 37/215 (17%)
Query: 155 KDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPS 214
K P G P G++ LP + V ++G G PP P GPPGLP
Sbjct: 1242 KTGPVGPAGPAGKPGPDGLRGLPGS-------VGQQG-RPGATGQAGPPG-PVGPPGLPG 1292
Query: 215 PPLPEEALGTRS-------------PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
A G + G+ + + GP+G + E+ +P P G
Sbjct: 1293 LRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGG 1352
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGAR-PPGEGSSTGASPESPP 320
PGL KGA G G GP+G+ G + PPG G + P
Sbjct: 1353 PPGLPGPAGPKGAKGATGPG--------------GPKGEKGVQGPPGHPGPPGEVIQPLP 1398
Query: 321 GAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGEL 355
++ S E +G P PG L
Sbjct: 1399 IQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGL 1433
Score = 33.5 bits (75), Expect = 1.6
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 432 KEEYEGSGKPESEPKELKTAGEKEPQLSEACGP--TEEGAGERELEGPGLLCMAGHTGPE 489
++ + P+ +P L +EPQ A GP + GE + PG+L + G GPE
Sbjct: 239 QQPHRAQRSPQQQPSRLHRPQNQEPQSQAAHGPRGLKGEKGEPAVLEPGML-VEGPPGPE 297
Query: 490 GP 491
GP
Sbjct: 298 GP 299
>gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein [Homo
sapiens]
Length = 1736
Score = 65.5 bits (158), Expect = 4e-10
Identities = 108/379 (28%), Positives = 129/379 (34%), Gaps = 34/379 (8%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
P GPPG P P P A G + G P+ GP G V LP P G G
Sbjct: 1028 PIGPPGRPGPQGPPGAAGEKGV-PGEKGPI-GPTGRDGVQGPVGLPGPAGPPGVAGEDGD 1085
Query: 266 SRVRTVPTRKGA-GGKGRHRRHR-----AWMHQKG-LGPRGQDGARPPGEGSSTGASPES 318
P +KG G KG H + Q G G G+ GAR P +G E
Sbjct: 1086 KGEVGDPGQKGTKGNKGEHGPPGPPGPIGPVGQPGAAGADGEPGARGP-QGHFGAKGDEG 1144
Query: 319 PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG 376
G P L+ P+ GE P+ P G G G GA+GP G P G
Sbjct: 1145 TRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQGPP--GG 1202
Query: 377 KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYE 436
GN G S G PG K + G P E P +
Sbjct: 1203 VGNLGPPGEKGEPGES-GSPGIQGEPGVKGPRGERGEKGESGQPGEPGPPG----PKGPT 1257
Query: 437 GSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEG----PGLLCMAGHTGPEGP 491
G P+ P + G+ P E ++GA G+R +G PG G GP GP
Sbjct: 1258 GDDGPKGNPGPVGFPGDPGPP-GEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGP 1316
Query: 492 L---SDTPTPPLETVQEGKGDNIPEEALAVSVSDHP----DVAWDLMASGFLILTGGVDQ 544
L +P E Q GKG A+ P A G L G V Q
Sbjct: 1317 LGKRGPAGSPGSEGRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQ 1376
Query: 545 SGRALLT--ITPPCPPEEP 561
GR T PP P P
Sbjct: 1377 QGRPGATGQAGPPGPVGPP 1395
Score = 58.9 bits (141), Expect = 4e-08
Identities = 99/357 (27%), Positives = 122/357 (34%), Gaps = 83/357 (23%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALG-------------TRSPGDGHNAPVEGPEGEYVE 244
P P P+GP G P P +G + SPG V+GP GE E
Sbjct: 1179 PGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGESGSPGIQGEPGVKGPRGERGE 1238
Query: 245 LLEVTLPVR------GSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPR 298
E P PT +G G P G G+G GPR
Sbjct: 1239 KGESGQPGEPGPPGPKGPTGDDGPKGNPGPVGFPGDPGPPGEG--------------GPR 1284
Query: 299 GQDGAR-------PPGEGSSTGASPES-PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPL 350
GQDGA+ PG+ S G + E+ PPG A SE G A G
Sbjct: 1285 GQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKRGPAGSPGSEGRQGGKG-AKGD--- 1340
Query: 351 RPGELRGGGGGGQ-GAEGPPGTPRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSP----- 402
PG + G G G GP G P G +G GR GA + G P+ P
Sbjct: 1341 -PGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGPPGLPG 1399
Query: 403 -----GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEK-EP 456
G K + H +G + P E +G P + G+K E
Sbjct: 1400 LRGDAGAKGEKGHPGLIGLIGPPGE-------------QGEKGDRGLPGPQGSPGQKGEM 1446
Query: 457 QLSEACGPTEEGAGERELEGP-GLLCMAGHTGPEGPLSDT--------PTPPLETVQ 504
+ A GP G G L GP G G TGP GP + P PP E +Q
Sbjct: 1447 GIPGASGPIGPG-GPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQ 1502
Score = 50.8 bits (120), Expect = 1e-05
Identities = 86/305 (28%), Positives = 107/305 (35%), Gaps = 41/305 (13%)
Query: 207 SGPPGLPSPPLPEEALGTR-SPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGL 265
SGP G P P G R + G G +G + E LP P G PG
Sbjct: 834 SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLP---GPQGPNGFPGP 890
Query: 266 SRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPP-GEGSSTGASPE 317
P + G G R + + G +GP+G G P GE G P
Sbjct: 891 KGPPGPPGKDGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPG--PP 948
Query: 318 SPPGAEAVPEAAVLEVS--EPPAEAVGEASGSCPLR--PGELRG-----GGGGGQGAEGP 368
PPG + +P A E + +P G LR PGE RG GG G +G EGP
Sbjct: 949 GPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGE-RGLPGTAGGPGLKGNEGP 1007
Query: 369 PGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPEC 428
G P G RGA GG P PG A G P E K P
Sbjct: 1008 SGPPGPAGSPGE-------RGAAGSGGPIGP--PGRPGPQGPPGAAGEKGVPGE-KGPIG 1057
Query: 429 HLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGA-GERELEGPGLLCMAGHTG 487
++ +G AGE + E P ++G G + GP G G
Sbjct: 1058 PTGRDGVQGPVGLPGPAGPPGVAGE-DGDKGEVGDPGQKGTKGNKGEHGP-----PGPPG 1111
Query: 488 PEGPL 492
P GP+
Sbjct: 1112 PIGPV 1116
Score = 49.3 bits (116), Expect = 3e-05
Identities = 82/326 (25%), Positives = 109/326 (33%), Gaps = 41/326 (12%)
Query: 206 PSGPPGLPSPPLPEEALGTRS----PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P G PGLP P + G PG N GP+G G P G
Sbjct: 674 PQGKPGLPGMPGSDGPPGHPGKEGPPGTKGNQGPSGPQGPL-----------GYP-GPRG 721
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-------LGPRGQDGARPPGEGSSTGA 314
G+ +R + KG G+ + + KG G RG+DG P G TG
Sbjct: 722 VKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDRGEVGVPGSRGEDG--PEGPKGRTGP 779
Query: 315 SPE-SPPGAEAVP-EAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGG-QGAEGPPGT 371
+ + PPG + V + P + S P PG G G G GP G
Sbjct: 780 TGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGPRGE 839
Query: 372 PRRTG-KGNRRKKRAAGR-GALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECH 429
TG +G R + A G+ GA G P P + + P P P
Sbjct: 840 RGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGK 899
Query: 430 LVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPE 489
+G + E+ G+ P + AGE G + GH GP
Sbjct: 900 ------DGLPGHPGQRGEVGFQGKTGPPGPPGVVGPQGAAGET-----GPMGERGHPGPP 948
Query: 490 GPLSDTPTPPLETVQEGKGDNIPEEA 515
GP + P + KGD P A
Sbjct: 949 GPPGEQGLPGTAGKEGTKGDPGPPGA 974
Score = 48.5 bits (114), Expect = 5e-05
Identities = 91/327 (27%), Positives = 111/327 (33%), Gaps = 82/327 (25%)
Query: 187 VHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELL 246
V + G++V P P GPPG+ P P G R P A + G +G
Sbjct: 390 VLEPGMLVEGPPGPEGPAGLIGPPGIQGNPGPVGDPGERGPPG--RAGLPGSDG------ 441
Query: 247 EVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG-----RHRRHRAWMHQKGLGPRGQD 301
A G PG S + G G KG + + +A + Q L RG
Sbjct: 442 ------------APGPPGTSLMLPFRFGSGGGDKGPVVAAQEAQAQAILQQARLALRG-- 487
Query: 302 GARPPGEGSSTG-ASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG 360
PPG TG P PG+ PG L+G G
Sbjct: 488 ---PPGPMGYTGRPGPLGQPGS-----------------------------PG-LKGESG 514
Query: 361 --GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLP 418
G QG GP G GK RR RA GA GD PG K D + L LP
Sbjct: 515 DLGPQGPRGPQGLTGPPGKAGRR-GRAGADGARGMPGD-----PGVKGDRGF-DGLPGLP 567
Query: 419 SPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACGPTE--EGAGERELE 475
H+ +G P E E GE P+ L GP G +
Sbjct: 568 GEKGHR------GDTGAQGLPGPPGEDGERGDDGEIGPRGLPGESGPRGLLGPKGPPGIP 621
Query: 476 G-PGLLCMAGHTGPEGPL--SDTPTPP 499
G PG+ M G GP+G L P PP
Sbjct: 622 GPPGVRGMDGPQGPKGSLGPQGEPGPP 648
Score = 48.1 bits (113), Expect = 6e-05
Identities = 85/322 (26%), Positives = 113/322 (35%), Gaps = 52/322 (16%)
Query: 206 PSGPPG---LPSPPLPEEALGTRS-PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
P GPPG LP P P G + PG + G G+ E + +G T G
Sbjct: 869 PHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGE-----VGFQGK-TGPPG 922
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGAR----PPGEGSSTG-AS 315
PG+ + G G+ H ++GL G G++G + PPG G A
Sbjct: 923 PPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGAPGKDGPAG 982
Query: 316 PESPPGAEAVPEAA---VLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTP 372
PG +P A L+ +E P+ G A PGE RG G G G GPPG P
Sbjct: 983 LRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGS-----PGE-RGAAGSG-GPIGPPGRP 1035
Query: 373 RRTG-KGNRRKKRAAGR----GALSRGGDSAPL-------------SPGDKEDASHQEAL 414
G G +K G G R G P+ GDK +
Sbjct: 1036 GPQGPPGAAGEKGVPGEKGPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQK 1095
Query: 415 GNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGEREL 474
G + EH P G P +P GE + + + G R
Sbjct: 1096 GTKGNKGEHGPP-------GPPGPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGF 1148
Query: 475 EG-PGLLCMAGHTGPEGPLSDT 495
G PG + + G GP G +T
Sbjct: 1149 NGPPGPIGLQGLPGPSGEKGET 1170
Score = 45.1 bits (105), Expect = 5e-04
Identities = 87/313 (27%), Positives = 109/313 (34%), Gaps = 67/313 (21%)
Query: 206 PSGPPGLPSPPLPEEALGTRSPGDGHNAPVE--GPEGEYVELLEVTLPVRGSPTDAEGSP 263
P GPPG+P PP G R DG P GP+GE P +G+P
Sbjct: 614 PKGPPGIPGPP------GVRGM-DGPQGPKGSLGPQGE------------PGPPGQQGTP 654
Query: 264 GLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAE 323
G + +P +GA G + GP+G+ G PG S G P PG E
Sbjct: 655 G---TQGLPGPQGAIGPHGEK-----------GPQGKPGL--PGMPGSDG--PPGHPGKE 696
Query: 324 AVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRG--GGGGGQGAEGPPGTPRRTG-KGNR 380
P + P +G +RG G G +G +G PG G KG+R
Sbjct: 697 GPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIRGLKGHKGEKGEDGFPGFKGDIGVKGDR 756
Query: 381 RKKRAAG-RGALSRGGDSAPLSP-GDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGS 438
+ G RG G P GD G L P LP Y G
Sbjct: 757 GEVGVPGSRGEDGPEGPKGRTGPTGDPGPPGLMGEKGKLGVPG---LP-------GYPGR 806
Query: 439 GKPESE---PKELKTAGEKEPQ-LSEACGPTEE--GAGERELEGP-------GLLCMAGH 485
P+ P +GEK + LS GP E G R GP G +G
Sbjct: 807 QGPKGSLGFPGFPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGG 866
Query: 486 TGPEGPLSDTPTP 498
GP GP + P
Sbjct: 867 DGPHGPPGERGLP 879
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/91 (31%), Positives = 39/91 (42%), Gaps = 8/91 (8%)
Query: 198 PSTLPPELPSGPPGLPSPPLPEEALGTRSPG-----DGHNAPV--EGPEGEYVELLEVTL 250
P P P GPPGLP P P+ A G PG G P GP GE ++ L + +
Sbjct: 1449 PGASGPIGPGGPPGLPGPAGPKGAKGATGPGGPKGEKGVQGPPGHPGPPGEVIQPLPIQM 1508
Query: 251 PVRGSPTDAEGSPGLSRVRTVPTRKGAGGKG 281
P + + +GS + +PT G G
Sbjct: 1509 P-KKTRRSVDGSRLMQEDEAIPTGGAPGSPG 1538
Score = 42.7 bits (99), Expect = 0.003
Identities = 64/242 (26%), Positives = 86/242 (35%), Gaps = 53/242 (21%)
Query: 198 PSTLPPELPSGPPGLPSPP----LPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLP-V 252
P P P+GP G P P LP PG A GP G LP +
Sbjct: 1347 PGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGRPGATGQAGPPGPVGP------PGLPGL 1400
Query: 253 RGSP--TDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEG 309
RG +G PGL + P +G G +GL GP+G G + GE
Sbjct: 1401 RGDAGAKGEKGHPGLIGLIGPPGEQGEKG------------DRGLPGPQGSPGQK--GEM 1446
Query: 310 SSTGAS-PESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGP 368
GAS P P G +P PA G + P GG G +G +GP
Sbjct: 1447 GIPGASGPIGPGGPPGLPG---------PAGPKGAKGATGP-------GGPKGEKGVQGP 1490
Query: 369 PGTPRRTG--------KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP 420
PG P G + ++ +R+ L + ++ P +E G+L S
Sbjct: 1491 PGHPGPPGEVIQPLPIQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGLEEIFGSLDSL 1550
Query: 421 SE 422
E
Sbjct: 1551 RE 1552
Score = 38.9 bits (89), Expect = 0.038
Identities = 67/249 (26%), Positives = 83/249 (33%), Gaps = 51/249 (20%)
Query: 296 GPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGEL 355
GPRG G + G E PPG PE + P + G R
Sbjct: 377 GPRGLKGEKGEPAVLEPGMLVEGPPG----PEGPAGLIGPPGIQGNPGPVGDPGERGPPG 432
Query: 356 RGGGGGGQGAEGPPGT----PRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDA--- 408
R G G GA GPPGT P R G G GGD P+ + A
Sbjct: 433 RAGLPGSDGAPGPPGTSLMLPFRFGSG---------------GGDKGPVVAAQEAQAQAI 477
Query: 409 --SHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQ-LSEACG-- 463
+ AL P P + L + GS + E +L G + PQ L+ G
Sbjct: 478 LQQARLALRGPPGPMGYTGRPGPLGQ---PGSPGLKGESGDLGPQGPRGPQGLTGPPGKA 534
Query: 464 --------------PTEEGA-GERELEG-PGLLCMAGHTGPEGPLSDTPTPPLETVQEGK 507
P + G G+R +G PGL GH G G P PP E + G
Sbjct: 535 GRRGRAGADGARGMPGDPGVKGDRGFDGLPGLPGEKGHRGDTG-AQGLPGPPGEDGERGD 593
Query: 508 GDNIPEEAL 516
I L
Sbjct: 594 DGEIGPRGL 602
Score = 38.5 bits (88), Expect = 0.050
Identities = 53/215 (24%), Positives = 73/215 (33%), Gaps = 37/215 (17%)
Query: 155 KDRPTGRLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPS 214
K P G P G++ LP + V ++G G PP P GPPGLP
Sbjct: 1349 KTGPVGPAGPAGKPGPDGLRGLPGS-------VGQQG-RPGATGQAGPPG-PVGPPGLPG 1399
Query: 215 PPLPEEALGTRS-------------PGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEG 261
A G + G+ + + GP+G + E+ +P P G
Sbjct: 1400 LRGDAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKGEMGIPGASGPIGPGG 1459
Query: 262 SPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGAR-PPGEGSSTGASPESPP 320
PGL KGA G G GP+G+ G + PPG G + P
Sbjct: 1460 PPGLPGPAGPKGAKGATGPG--------------GPKGEKGVQGPPGHPGPPGEVIQPLP 1505
Query: 321 GAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGEL 355
++ S E +G P PG L
Sbjct: 1506 IQMPKKTRRSVDGSRLMQEDEAIPTGGAPGSPGGL 1540
>gi|89142737 alpha 3 type IV collagen isoform 5 precursor [Homo
sapiens]
Length = 1424
Score = 65.5 bits (158), Expect = 4e-10
Identities = 102/345 (29%), Positives = 127/345 (36%), Gaps = 56/345 (16%)
Query: 203 PELPSGPPGLPSPP-------LP--EEALGTR-SPGDGHNAPVEG------------PEG 240
P +P GPPGLP P +P + A G + SPG N + G +G
Sbjct: 480 PYIP-GPPGLPGLPGLHGVKGIPGRQGAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKG 538
Query: 241 EYVELL--EVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKG-LGP 297
E E L E + V G P G PG + +P G G + A +KG GP
Sbjct: 539 EKGETLQPEGQVGVPGDP-GLRGQPGRKGLDGIPGTPGVKGLPGPKGELALSGEKGDQGP 597
Query: 298 RGQDGAR----PPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAV--GEASGSCPLR 351
G G+ P G G P+ PG + V PP EA GE S S P+
Sbjct: 598 PGDPGSPGSPGPAGPAGPPGYGPQGEPGLQGTQ--GVPGAPGPPGEAGPRGELSVSTPVP 655
Query: 352 PGELRGGGGGGQGAEGPPGTPRRTGK-GNRRKKRAAGRGALSRGGDSAPLSPGDKEDASH 410
G G G +GPPG P GK G+ G + G P PG K D
Sbjct: 656 GPPGPPGPPGHPGPQGPPGIPGSLGKCGDPGLPGPDGEPGIP--GIGFPGPPGPKGDQGF 713
Query: 411 QEALGNLPSPSEHKLPECHLVKEEYEGSGKP-----ESEPKELKTAGEKEPQLSEACGPT 465
G+L P + P GKP + EP G P G +
Sbjct: 714 PGTKGSLGCPGKMGEPGL---------PGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNS 764
Query: 466 EEGAGERELEG-PGLLCMAGHTGPEGPLSD--TPTPPLETVQEGK 507
E GE L G PGL G+ G +GP D P PP E G+
Sbjct: 765 GE-HGEIGLPGLPGLPGTPGNEGLDGPRGDPGQPGPPGEQGPPGR 808
Score = 58.2 bits (139), Expect = 6e-08
Identities = 88/305 (28%), Positives = 108/305 (35%), Gaps = 37/305 (12%)
Query: 202 PPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVE--LLEVTLPVRGSP--T 257
PP + GPPGLP P +G R GD + GP GE E LL RG+P
Sbjct: 1132 PPGI-RGPPGLPGFPGSPGPMGIR--GDQGRDGIPGPAGEKGETGLLRAPPGPRGNPGAQ 1188
Query: 258 DAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPE 317
A+G G +P RKGA G R + GP G GA PG+ + G
Sbjct: 1189 GAKGDRGAPGFPGLPGRKGAMGDAGPRGPTG--IEGFPGPPGLPGAIIPGQTGNRG---- 1242
Query: 318 SPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGK 377
PPG+ P A PP V G G G G +GPPGT G
Sbjct: 1243 -PPGSRGSPGAP--GPPGPPGSHVIGIKGD---------KGSMGHPGPKGPPGTAGDMGP 1290
Query: 378 GNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNL--PSPSEHKLP------ECH 429
R RG PG K + + LG++ P P K P
Sbjct: 1291 PGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFLGSIGPPGPIGPKGPPGVRGDPGT 1350
Query: 430 LVKEEYEGSGKPESEPKELKTAGEKEPQLSEA----CGPTEEGAGERELEGPGLLCMAGH 485
L GS P P E GE P CGP + + + PG G+
Sbjct: 1351 LKIISLPGSPGPPGTPGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDGKPGTPGPAGEKGN 1410
Query: 486 TGPEG 490
G +G
Sbjct: 1411 KGSKG 1415
Score = 53.1 bits (126), Expect = 2e-06
Identities = 87/331 (26%), Positives = 111/331 (33%), Gaps = 80/331 (24%)
Query: 203 PELPSGPPGLPSPPLPEEALGTRSPGDGHNAP----VEGPEGEYVELLEVTLPVRGSP-T 257
P+ PSGPPG+P P G+ PG AP ++G +GE RG P
Sbjct: 370 PQGPSGPPGVPGSP------GSSRPG-LRGAPGWPGLKGSKGE-----------RGRPGK 411
Query: 258 DAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPE 317
DA G+PG P G+ GP G PPG+ +
Sbjct: 412 DAMGTPGSPGCAGSPGLPGSP-----------------GPPG-----PPGD----IVFRK 445
Query: 318 SPPGAEAVP----EAAVLEVSEPPAEAVGEASGSCPLRPGE--------LRG-----GGG 360
PPG +P + V P E G CP PG L G G
Sbjct: 446 GPPGDHGLPGYLGSPGIPGVDGPKGEP-GLLCTQCPYIPGPPGLPGLPGLHGVKGIPGRQ 504
Query: 361 GGQGAEGPPGTPRRTG----------KGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASH 410
G G +G PG+P TG +G+ K G G P PG +
Sbjct: 505 GAAGLKGSPGSPGNTGLPGFPGFPGAQGDPGLKGEKGETLQPEGQVGVPGDPGLRGQPGR 564
Query: 411 QEALGNLPSPSEHKL--PECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEG 468
+ G +P L P+ L +G P +P + G P GP E
Sbjct: 565 KGLDGIPGTPGVKGLPGPKGELALSGEKGDQGPPGDPGSPGSPGPAGPAGPPGYGPQGEP 624
Query: 469 AGERELEGPGLLCMAGHTGPEGPLS-DTPTP 498
+ PG G GP G LS TP P
Sbjct: 625 GLQGTQGVPGAPGPPGEAGPRGELSVSTPVP 655
Score = 51.2 bits (121), Expect = 7e-06
Identities = 89/329 (27%), Positives = 115/329 (34%), Gaps = 48/329 (14%)
Query: 206 PSGPPGLPS-------PPLPEEALGTRSPGDGHNAPVEGPEGEYV------------ELL 246
P GPPG+P P LP PG G P GP+G+ ++
Sbjct: 669 PQGPPGIPGSLGKCGDPGLPGPDGEPGIPGIGFPGP-PGPKGDQGFPGTKGSLGCPGKMG 727
Query: 247 EVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHR-----------AWMHQKGL 295
E LP + A+G P ++ T G +G H +GL
Sbjct: 728 EPGLPGKPGLPGAKGEPAVAMPGGPGTPGFPGERGNSGEHGEIGLPGLPGLPGTPGNEGL 787
Query: 296 -GPRGQDGAR-PPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPG 353
GPRG G PPGE G E P GA+ +P L+ + G P PG
Sbjct: 788 DGPRGDPGQPGPPGEQGPPGRCIEGPRGAQGLPGLNGLKGQQGRRGKTGPKGD--PGIPG 845
Query: 354 ELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLS-PGDKEDASHQE 412
R G G G+ G PG G +R G L G+ + G
Sbjct: 846 LDRSGFPGETGSPGIPGHQGEMGPLGQR-GYPGNPGILGPPGEDGVIGMMGFPGAIGPPG 904
Query: 413 ALGNLPSPSEHKLPECHLVKEEY-------EGSGKPESEPKELK-TAGEK-EPQLSEACG 463
GN +P + P VK + E K P E+ G+K EP L G
Sbjct: 905 PPGNPGTPGQRGSPGIPGVKGQRGTPGAKGEQGDKGNPGPSEISHVIGDKGEPGLKGFAG 964
Query: 464 PTEEGAGERELEG-PGLLCMAGHTGPEGP 491
E G R + G PGL + G GP GP
Sbjct: 965 NPGE-KGNRGVPGMPGLKGLKGLPGPAGP 992
Score = 51.2 bits (121), Expect = 7e-06
Identities = 66/227 (29%), Positives = 86/227 (37%), Gaps = 36/227 (15%)
Query: 208 GPPGLPSPPLPEEALGTRSPGDGHNAP----VEGPEGEYVELLEVTLPVRGSPTDAEGSP 263
GPPGLP +P + G R P +P GP G +V ++ G P +G P
Sbjct: 1225 GPPGLPGAIIPGQT-GNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHP-GPKGPP 1282
Query: 264 GLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPGEGSSTG----ASPES 318
G + P R GA G R +G G +G+ G PG S G P+
Sbjct: 1283 GTAGDMGPPGRLGAPGTPGLPGPRGDPGFQGFPGVKGEKG--NPGFLGSIGPPGPIGPKG 1340
Query: 319 PPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKG 378
PPG P L++ P S P PGE G QG GPPG P G
Sbjct: 1341 PPGVRGDP--GTLKIISLP------GSPGPPGTPGE-----PGMQGEPGPPGPPGNLGPC 1387
Query: 379 NRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSPSEHKL 425
R K G D P +PG + ++ + G P H+L
Sbjct: 1388 GPRGK---------PGKDGKPGTPGPAGEKGNKGSKGE-PESLFHQL 1424
Score = 49.3 bits (116), Expect = 3e-05
Identities = 57/197 (28%), Positives = 77/197 (39%), Gaps = 17/197 (8%)
Query: 191 GLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTL 250
G ++ Q P G PG P PP P + GD + GP+G ++
Sbjct: 1231 GAIIPGQTGNRGPPGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP 1290
Query: 251 PVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGAR-PPGEG 309
P R A G+PGL R P +G G + + ++ +GP G G + PPG
Sbjct: 1291 PGR---LGAPGTPGLPGPRGDPGFQGFPGVKGEKGNPGFL--GSIGPPGPIGPKGPPGVR 1345
Query: 310 SSTGA-SPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQ-GAEG 367
G S PG+ P P E + P PG L G G+ G +G
Sbjct: 1346 GDPGTLKIISLPGSPGPPGT--------PGEPGMQGEPGPPGPPGNLGPCGPRGKPGKDG 1397
Query: 368 PPGTPRRTG-KGNRRKK 383
PGTP G KGN+ K
Sbjct: 1398 KPGTPGPAGEKGNKGSK 1414
Score = 48.5 bits (114), Expect = 5e-05
Identities = 68/227 (29%), Positives = 81/227 (35%), Gaps = 52/227 (22%)
Query: 198 PSTLPPELPSGPPGLP-SPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSP 256
P L P P G PG P SP LP + PG + +G +G L +RG P
Sbjct: 1091 PGHLGPAGPEGAPGSPGSPGLPGK------PGPHGDLGFKGIKG-----LLGPPGIRGPP 1139
Query: 257 --TDAEGSPGLSRVRTVPTRKG----AGGKGRHRRHRAWMHQKGLGPRGQDGAR------ 304
GSPG +R R G AG KG RA GPRG GA+
Sbjct: 1140 GLPGFPGSPGPMGIRGDQGRDGIPGPAGEKGETGLLRA-----PPGPRGNPGAQGAKGDR 1194
Query: 305 --------PPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELR 356
P +G+ A P P G E P L P A G+ P
Sbjct: 1195 GAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGL----PGAIIPGQTGNRGP------- 1243
Query: 357 GGGGGGQGAEGPPGTPRRTGKGNRRKKRAAG----RGALSRGGDSAP 399
G G GA GPPG P G + K + G +G GD P
Sbjct: 1244 PGSRGSPGAPGPPGPPGSHVIGIKGDKGSMGHPGPKGPPGTAGDMGP 1290
Score = 44.7 bits (104), Expect = 7e-04
Identities = 88/314 (28%), Positives = 108/314 (34%), Gaps = 68/314 (21%)
Query: 203 PELPS--GPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAE 260
P LP GP GLP PP G PV GP G P
Sbjct: 173 PGLPGAPGPQGLPGPP-------------GFPGPV-GPPG---------------PPGFF 203
Query: 261 GSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSS-----TGAS 315
G PG R G KG H R H+ G +G G PPG + TG
Sbjct: 204 GFPGAMGPR--------GPKG-HMGERVIGHKGERGVKGLTG--PPGPPGTVIVTLTGPD 252
Query: 316 PESPPGAEAVPEAAVLEVSEP-PAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRR 374
+ E + A+ E P P+ GE+ GS PG+ G G G +G PG P
Sbjct: 253 NRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGAPGD--PGLQGKPGKDGVPGFPGS 310
Query: 375 TG-KGNRRKKRAAGR-GALSRGGDSAP---LSPGDKEDASHQEALGNLPSPSEHKLPECH 429
G KGNR G G + GD P P + D ++ P P +
Sbjct: 311 EGVKGNRGFPGLMGEDGIKGQKGDIGPPGFRGPTEYYDTYQEKGDEGTPGPPGPR----- 365
Query: 430 LVKEEYEGSGKPESEPKELKTAGEKEPQLSEACG-PTEEGA-GERELEGPGLLCMAGHTG 487
G P P + G P L A G P +G+ GER G + G G
Sbjct: 366 ----GARGPQGPSGPPGVPGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPG 421
Query: 488 PEGP--LSDTPTPP 499
G L +P PP
Sbjct: 422 CAGSPGLPGSPGPP 435
Score = 36.6 bits (83), Expect = 0.19
Identities = 79/310 (25%), Positives = 102/310 (32%), Gaps = 63/310 (20%)
Query: 208 GPPGLPSPPLPEEALG-TRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLS 266
G PG PP P LG T +PG+ + G G G P GS G
Sbjct: 985 GLPGPAGPPGPRGDLGSTGNPGEPGLRGIPGSMGNM-----------GMP----GSKGKR 1029
Query: 267 RVRTVPTRKGAGG-KGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAV 325
P R G G G H G +G G PG T P P G +
Sbjct: 1030 GTLGFPGRAGRPGLPGIH------------GLQGDKGE--PGYSEGTRPGPPGPTGDPGL 1075
Query: 326 PEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGK-------G 378
P + + P PG L G G +GA G PG+P GK G
Sbjct: 1076 P-----------GDMGKKGEMGQPGPPGHL--GPAGPEGAPGSPGSPGLPGKPGPHGDLG 1122
Query: 379 NRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALG--NLPSPSEHKLPECHLVKEEYE 436
+ K G + RG P PG + G +P P+ K E L++
Sbjct: 1123 FKGIKGLLGPPGI-RGPPGLPGFPGSPGPMGIRGDQGRDGIPGPAGEK-GETGLLRAPPG 1180
Query: 437 GSGKPESEPKELKTAGEKEPQLSEACGPTEEGA--GERELEG----PGL--LCMAGHTGP 488
G P ++ + P L G + G +EG PGL + G TG
Sbjct: 1181 PRGNPGAQGAKGDRGAPGFPGLPGRKGAMGDAGPRGPTGIEGFPGPPGLPGAIIPGQTGN 1240
Query: 489 EGPLSDTPTP 498
GP +P
Sbjct: 1241 RGPPGSRGSP 1250
Score = 36.2 bits (82), Expect = 0.25
Identities = 67/284 (23%), Positives = 95/284 (33%), Gaps = 77/284 (27%)
Query: 208 GPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEGEYVELLEVTLP------------VRGS 255
G GL PP P + G + ++G +G+ + E P +G+
Sbjct: 230 GVKGLTGPPGPPGTVIVTLTGPDNRTDLKGEKGDKGAMGEPGPPGPSGLPGESYGSEKGA 289
Query: 256 PTDA--EGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGL-GPRGQDGARPPG-EGSS 311
P D +G PG V P +G G +R M + G+ G +G G PPG G +
Sbjct: 290 PGDPGLQGKPGKDGVPGFPGSEGVKG---NRGFPGLMGEDGIKGQKGDIG--PPGFRGPT 344
Query: 312 TGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGT 371
G E P PP G G QG GPPG
Sbjct: 345 EYYDTYQEKGDEGTPG--------PPGPR-----------------GARGPQGPSGPPGV 379
Query: 372 PRRTG---------------KGNRRKKRAAGRGAL----------SRGGDSAPLSPGDKE 406
P G KG++ ++ G+ A+ S G +P PG
Sbjct: 380 PGSPGSSRPGLRGAPGWPGLKGSKGERGRPGKDAMGTPGSPGCAGSPGLPGSPGPPGPPG 439
Query: 407 DASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKT 450
D ++ P +H LP +L G P+ EP L T
Sbjct: 440 DIVFRKG-----PPGDHGLPG-YLGSPGIPGVDGPKGEPGLLCT 477
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,876,756
Number of Sequences: 37866
Number of extensions: 4635639
Number of successful extensions: 31262
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 1096
Number of HSP's that attempted gapping in prelim test: 22534
Number of HSP's gapped (non-prelim): 6637
length of query: 1519
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1404
effective length of database: 13,892,928
effective search space: 19505670912
effective search space used: 19505670912
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.