Guide to the Human Genome
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Search of human proteins with 5032027

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
sapiens]
         (425 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...   889   0.0  
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...   883   0.0  
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...   818   0.0  
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]            800   0.0  
gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]          174   2e-43
gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo sap...   174   2e-43
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]     124   1e-28
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     92   1e-18
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              88   1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     85   1e-16
gi|217330644 WD repeat domain 12 protein [Homo sapiens]                82   9e-16
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               80   4e-15
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             77   3e-14
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             77   3e-14
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             77   3e-14
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            77   4e-14
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            77   4e-14
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          76   5e-14
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          76   5e-14
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          76   5e-14
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            76   5e-14
gi|109627650 coronin 6 [Homo sapiens]                                  75   1e-13
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s...    75   1e-13
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo...    75   1e-13
gi|32189425 WD repeat domain 69 [Homo sapiens]                         74   2e-13
gi|58331266 WD repeat domain 59 [Homo sapiens]                         72   1e-12
gi|4757988 WD repeat domain 39 [Homo sapiens]                          72   1e-12
gi|113865883 WD repeat domain 38 [Homo sapiens]                        71   2e-12
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    71   2e-12
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s...    71   2e-12

>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score =  889 bits (2297), Expect = 0.0
 Identities = 425/425 (100%), Positives = 425/425 (100%)

Query: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
           MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD
Sbjct: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60

Query: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120
           FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK
Sbjct: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120

Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180
           INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG
Sbjct: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180

Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240
           YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE
Sbjct: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240

Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300
           SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL
Sbjct: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300

Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360
           WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE
Sbjct: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360

Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420
           DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP
Sbjct: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420

Query: 421 EGQGS 425
           EGQGS
Sbjct: 421 EGQGS 425


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score =  883 bits (2281), Expect = 0.0
 Identities = 424/425 (99%), Positives = 424/425 (99%), Gaps = 1/425 (0%)

Query: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
           MADKEA FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD
Sbjct: 1   MADKEA-FDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 59

Query: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120
           FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK
Sbjct: 60  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 119

Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180
           INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG
Sbjct: 120 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 179

Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240
           YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE
Sbjct: 180 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 239

Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300
           SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL
Sbjct: 240 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299

Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360
           WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE
Sbjct: 300 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 359

Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 420
           DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP
Sbjct: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDP 419

Query: 421 EGQGS 425
           EGQGS
Sbjct: 420 EGQGS 424


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score =  818 bits (2113), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 36  MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 95
           MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA
Sbjct: 1   MTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDA 60

Query: 96  SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 155
           SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT
Sbjct: 61  SHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYT 120

Query: 156 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 215
           KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK
Sbjct: 121 KHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGK 180

Query: 216 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 275
           VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE
Sbjct: 181 VVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE 240

Query: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 335
           VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS
Sbjct: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILAS 300

Query: 336 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 395
           SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE
Sbjct: 301 SGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSE 360

Query: 396 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 425
           DNIMQVWQMAENIYNDEDPEGSVDPEGQGS
Sbjct: 361 DNIMQVWQMAENIYNDEDPEGSVDPEGQGS 390


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score =  800 bits (2066), Expect = 0.0
 Identities = 380/426 (89%), Positives = 403/426 (94%), Gaps = 2/426 (0%)

Query: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
           MA KE  F+D VEERVINEEYKIWKKNTPFLYDLVMTHAL+WPSLT QWLP+VT+PEGKD
Sbjct: 1   MASKEM-FEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKD 59

Query: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIK 120
           +++H LVLGTHTSDEQNHLV+A V +PNDDAQFDASH DS+KGEFGGFGSV+GKIE EIK
Sbjct: 60  YALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIK 119

Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180
           INHEGEVNRARYMPQNP IIATKTPSSDVLVFDYTKHP+KPDPSGECNPDLRLRGHQKEG
Sbjct: 120 INHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEG 179

Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240
           YGLSWN NLSGHLLSASDDHT+CLWDI+A PKEGK+VDAK IFTGH+AVVEDV+WHLLHE
Sbjct: 180 YGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHE 239

Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300
           SLFGSVADDQKLMIWDTRSN TSKPSH VDAHTAEVNCLSFNPYSEFILATGSADKTVAL
Sbjct: 240 SLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 299

Query: 301 WDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAE 360
           WDLRNLKLKLH+FESHKDEIFQV WSPHNETILASSGTDRRLNVWDLSKIGEEQS EDAE
Sbjct: 300 WDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAE 359

Query: 361 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSV-D 419
           DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ+WQMAENIYNDE+ + +  +
Sbjct: 360 DGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSE 419

Query: 420 PEGQGS 425
            EGQGS
Sbjct: 420 LEGQGS 425


>gi|169165527 PREDICTED: similar to hCG1643855 [Homo sapiens]
          Length = 103

 Score =  174 bits (440), Expect = 2e-43
 Identities = 86/107 (80%), Positives = 91/107 (85%), Gaps = 4/107 (3%)

Query: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
           M +KEAAFD+AVEE VI EEYKIWK NT F YDLVMT ALEWPSLTAQWLPDVTRPEGKD
Sbjct: 1   MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60

Query: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGG 107
           FS HRLV GTHTS EQNHL    VQLP+DDAQ DASHY+S+KGE GG
Sbjct: 61  FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103


>gi|239742072 PREDICTED: hypothetical protein LOC391556 [Homo
           sapiens]
          Length = 103

 Score =  174 bits (440), Expect = 2e-43
 Identities = 86/107 (80%), Positives = 91/107 (85%), Gaps = 4/107 (3%)

Query: 1   MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKD 60
           M +KEAAFD+AVEE VI EEYKIWK NT F YDLVMT ALEWPSLTAQWLPDVTRPEGKD
Sbjct: 1   MTNKEAAFDNAVEEHVIKEEYKIWKNNTSFPYDLVMTQALEWPSLTAQWLPDVTRPEGKD 60

Query: 61  FSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGG 107
           FS HRLV GTHTS EQNHL    VQLP+DDAQ DASHY+S+KGE GG
Sbjct: 61  FSSHRLVPGTHTSVEQNHL----VQLPSDDAQLDASHYNSKKGECGG 103


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score =  124 bits (312), Expect = 1e-28
 Identities = 73/243 (30%), Positives = 122/243 (50%), Gaps = 17/243 (6%)

Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKV--VDA 219
           D   +  P     GH  EG+ L W+P ++G LL+      I LW     P +G    VD 
Sbjct: 199 DEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLW----TPTDGGSWHVDQ 254

Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTR-SNNTSKPSHSVDAHTAEVNC 278
           +  F GHT  VED+ W     ++F S + D  + IWD R + + +    +  AH  +VN 
Sbjct: 255 RP-FVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNV 313

Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLK--LKLHSFESHKDEIFQVQWSPHNETILASS 336
           +S++    F+L +G  D  + +WDLR  K    + +F+ H   +  V+W P +  + A+S
Sbjct: 314 ISWSRREPFLL-SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAAS 372

Query: 337 GTDRRLNVWDLS-----KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVIC 391
           G D ++  WDL+     + G+ ++     D P +LLF+H G T ++ +  W+P  P ++ 
Sbjct: 373 GADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGET-ELKELHWHPQCPGLLV 431

Query: 392 SVS 394
           S +
Sbjct: 432 STA 434



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 26/98 (26%), Positives = 42/98 (42%), Gaps = 16/98 (16%)

Query: 310 LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGE---EQSPEDAEDGPPEL 366
           + SF  H  E F + WSP     L +    + +++W  +  G    +Q P          
Sbjct: 207 IFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRP---------- 256

Query: 367 LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
            F+  GHT  + D  W+P E  V  S S D  +++W +
Sbjct: 257 -FV--GHTRSVEDLQWSPTENTVFASCSADASIRIWDI 291



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 32/136 (23%), Positives = 52/136 (38%), Gaps = 11/136 (8%)

Query: 121 INHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEG 180
           + H   V   ++ P    + A+ +  + + ++D    PSK               H  + 
Sbjct: 258 VGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTAT------AHDGDV 311

Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHE 240
             +SW+      LLS  DD  + +WD+    K G  V     F  H A V  V WH    
Sbjct: 312 NVISWS-RREPFLLSGGDDGALKIWDLRQF-KSGSPV---ATFKQHVAPVTSVEWHPQDS 366

Query: 241 SLFGSVADDQKLMIWD 256
            +F +   D ++  WD
Sbjct: 367 GVFAASGADHQITQWD 382


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 77/247 (31%), Positives = 118/247 (47%), Gaps = 35/247 (14%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           LRGH    Y   +  + SG LLS S+D +I  WD+ +            ++ GH   V D
Sbjct: 338 LRGHCGPVYSTRFLADSSG-LLSCSEDMSIRYWDLGSFTNT-------VLYQGHAYPVWD 389

Query: 233 --VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290
             +S + L+   F S + D+   +W   S + + P      H A+V+C+ F+P S + LA
Sbjct: 390 LDISPYSLY---FASGSHDRTARLW---SFDRTYPLRIYAGHLADVDCVKFHPNSNY-LA 442

Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350
           TGS DKTV LW  +     +  F  H+  +  + +SP N   LAS+G D+RL +WDL+  
Sbjct: 443 TGSTDKTVRLWSAQQGN-SVRLFTGHRGPVLSLAFSP-NGKYLASAGEDQRLKLWDLAS- 499

Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYN 410
                          L     GHT  I+  +++P +  +I S S DN ++VW +  N Y 
Sbjct: 500 -------------GTLYKELRGHTDNITSLTFSP-DSGLIASASMDNSVRVWDI-RNTYC 544

Query: 411 DEDPEGS 417
               +GS
Sbjct: 545 SAPADGS 551


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 63/231 (27%), Positives = 101/231 (43%), Gaps = 24/231 (10%)

Query: 176 HQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234
           H +E Y + W+      L+ S S D T+ LWD    P  GK +     F GH +++    
Sbjct: 110 HAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD----PTVGKSL---CTFRGHESIIYSTI 162

Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294
           W       F S + DQ L IWD ++         + AH AE+    +  Y+E +L TG+ 
Sbjct: 163 WSPHIPGCFASASGDQTLRIWDVKAAGVRIV---IPAHQAEILSCDWCKYNENLLVTGAV 219

Query: 295 DKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQ 354
           D ++  WDLRN++  +     H   I +V++SP + ++LAS   D  +  W+ SK     
Sbjct: 220 DCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK----- 274

Query: 355 SPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
                   P  LL     HT       ++   P  +   S D  ++++  A
Sbjct: 275 --------PDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYDPA 317



 Score = 79.0 bits (193), Expect = 8e-15
 Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 9/173 (5%)

Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233
           RGH+   Y   W+P++ G   SAS D T+ +WD+       K    + +   H A +   
Sbjct: 152 RGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV-------KAAGVRIVIPAHQAEILSC 204

Query: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293
            W   +E+L  + A D  L  WD R  N  +P   +  HT  +  + F+P+   +LA+ S
Sbjct: 205 DWCKYNENLLVTGAVDCSLRGWDLR--NVRQPVFELLGHTYAIRRVKFSPFHASVLASCS 262

Query: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
            D TV  W+       L + E H +    + +S  + T +A    D  + ++D
Sbjct: 263 YDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKIYD 315



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 54/227 (23%), Positives = 97/227 (42%), Gaps = 24/227 (10%)

Query: 181 YGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH- 239
           + ++W+ N    L++ S D ++ LWD +      K      ++  H   V  V W     
Sbjct: 71  FDVTWSENNEHVLITCSGDGSLQLWDTA------KAAGPLQVYKEHAQEVYSVDWSQTRG 124

Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVA 299
           E L  S + DQ + +WD       K   +   H + +    ++P+     A+ S D+T+ 
Sbjct: 125 EQLVVSGSWDQTVKLWDP---TVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLR 181

Query: 300 LWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359
           +WD++   +++    +H+ EI    W  +NE +L +   D  L  WDL  + +       
Sbjct: 182 IWDVKAAGVRI-VIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVF---- 236

Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
                ELL    GHT  I    ++P    V+ S S D  ++ W  ++
Sbjct: 237 -----ELL----GHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 52/187 (27%), Positives = 85/187 (45%), Gaps = 17/187 (9%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDH-------TICLWDISAVPKEGKVVDAKTIFTG 225
           LR   + GY   ++P L G L  A+  H       T+ + D    P E  +   ++ F  
Sbjct: 12  LRTPGRHGYAAEFSPYLPGRLACATAQHYGIAGCGTLLILD----PDEAGLRLFRS-FDW 66

Query: 226 HTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN-PY 284
           +  +  DV+W   +E +  + + D  L +WDT     + P      H  EV  + ++   
Sbjct: 67  NDGLF-DVTWSENNEHVLITCSGDGSLQLWDTA--KAAGPLQVYKEHAQEVYSVDWSQTR 123

Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344
            E ++ +GS D+TV LWD   +   L +F  H+  I+   WSPH     AS+  D+ L +
Sbjct: 124 GEQLVVSGSWDQTVKLWD-PTVGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRI 182

Query: 345 WDLSKIG 351
           WD+   G
Sbjct: 183 WDVKAAG 189



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 39/162 (24%), Positives = 61/162 (37%), Gaps = 38/162 (23%)

Query: 281 FNPYSEFILATGSADK-------TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETIL 333
           F+PY    LA  +A         T+ + D     L+L       D +F V WS +NE +L
Sbjct: 24  FSPYLPGRLACATAQHYGIAGCGTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVL 83

Query: 334 ASSGTDRRLNVWDLSK------IGEEQSPE----DAEDGPPELLFIHG------------ 371
            +   D  L +WD +K      + +E + E    D      E L + G            
Sbjct: 84  ITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPT 143

Query: 372 ---------GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
                    GH + I    W+P+ P    S S D  +++W +
Sbjct: 144 VGKSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDV 185


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 69/233 (29%), Positives = 110/233 (47%), Gaps = 36/233 (15%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           L GH    YG S++P+ + +LLS+S+D T+ LW +       +       + GH   V D
Sbjct: 539 LYGHSGPVYGASFSPDRN-YLLSSSEDGTVRLWSL-------QTFTCLVGYKGHNYPVWD 590

Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292
             +   +   F S   D+   +W T   +  +P      H A+VNC  F+P S ++ ATG
Sbjct: 591 TQFSP-YGYYFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYV-ATG 645

Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS---K 349
           SAD+TV LWD+ N    +  F  HK  I  + +SP N   LA+  TD R+ +WD+     
Sbjct: 646 SADRTVRLWDVLNGNC-VRIFTGHKGPIHSLTFSP-NGRFLATGATDGRVLLWDIGHGLM 703

Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
           +GE +                 GHT  +    ++  +  ++ S S DN +++W
Sbjct: 704 VGELK-----------------GHTDTVCSLRFS-RDGEILASGSMDNTVRLW 738



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 13/128 (10%)

Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234
           GH  +     ++PN S ++ + S D T+ LWD+      G  V    IFTGH   +  ++
Sbjct: 625 GHLADVNCTRFHPN-SNYVATGSADRTVRLWDVL----NGNCV---RIFTGHKGPIHSLT 676

Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294
           +   +     + A D ++++WD            +  HT  V  L F+   E ILA+GS 
Sbjct: 677 FSP-NGRFLATGATDGRVLLWDI---GHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSM 731

Query: 295 DKTVALWD 302
           D TV LWD
Sbjct: 732 DNTVRLWD 739


>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
          Length = 423

 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 54/174 (31%), Positives = 90/174 (51%), Gaps = 13/174 (7%)

Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTA 228
           P + L GH +    + W+   +  + SAS DHTI +WD+ +          K+  TG+  
Sbjct: 249 PIVTLSGHMEAVSSVLWSD--AEEICSASWDHTIRVWDVESG-------SLKSTLTGNK- 298

Query: 229 VVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFI 288
           V   +S+  L + L  S + D+ + +WD R+ + S  S S+ +HT  V  + ++P  E  
Sbjct: 299 VFNCISYSPLCKRL-ASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQ 357

Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342
           L +GS D  V LWD R+ K  L+   +H+D++  V W+  +  +L S G D +L
Sbjct: 358 LISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWT--DTGLLLSGGADNKL 409



 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 46/170 (27%), Positives = 71/170 (41%), Gaps = 16/170 (9%)

Query: 224 TGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNP 283
           +GH   V  V W    E    S + D  + +WD  S +      S        NC+S++P
Sbjct: 254 SGHMEAVSSVLWSDAEEIC--SASWDHTIRVWDVESGSLK----STLTGNKVFNCISYSP 307

Query: 284 YSEFILATGSADKTVALWDLRNLKLKLHSFE--SHKDEIFQVQWSPHNETILASSGTDRR 341
             +  LA+GS D+ + LWD R     L S    SH   +  V+WSP +E  L S   D  
Sbjct: 308 LCKR-LASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNI 366

Query: 342 LNVWD-------LSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNP 384
           + +WD       L  +   +    + D     L + GG   K+  + ++P
Sbjct: 367 VKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSP 416



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 67/254 (26%), Positives = 107/254 (42%), Gaps = 47/254 (18%)

Query: 175 GHQKEGYGLSW--NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           GH      ++W    +LS  LLSAS D TI LW+ +    E   V A     GH   V+ 
Sbjct: 138 GHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNV---ERNKVKALHCCRGHAGSVDS 194

Query: 233 VSWHLLHESLFGSVADDQKLMIWDT----------RSNN-------------TSKPSHSV 269
           ++      + F S + D+ L IW T           S N             T  P  ++
Sbjct: 195 IAVDG-SGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTL 253

Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQ-VQWSPH 328
             H   V+ + ++   E  + + S D T+ +WD+ +  LK  +   +K  +F  + +SP 
Sbjct: 254 SGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDVESGSLK-STLTGNK--VFNCISYSPL 308

Query: 329 NETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPW 388
            +  LAS  TDR + +WD             +DG    L +   HT  ++   W+P    
Sbjct: 309 CKR-LASGSTDRHIRLWD----------PRTKDGSLVSLSLTS-HTGWVTSVKWSPTHEQ 356

Query: 389 VICSVSEDNIMQVW 402
            + S S DNI+++W
Sbjct: 357 QLISGSLDNIVKLW 370



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 62/290 (21%), Positives = 101/290 (34%), Gaps = 86/290 (29%)

Query: 133 MPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGH 192
           MP +  +      S +V+  +Y +  + P P  +C             +   W  ++ G 
Sbjct: 64  MPLDKHMEMENISSEEVVEIEYVEKYTAPQPE-QCM------------FHDDWISSIKGA 110

Query: 193 ---LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADD 249
              +L+ S D T  +W +     EGK +       GHT VV+DV+W              
Sbjct: 111 EEWILTGSYDKTSRIWSL-----EGKSI---MTIVGHTDVVKDVAW-------------- 148

Query: 250 QKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDL---RNL 306
                         K S         ++CL         L + S D+T+ LW+    RN 
Sbjct: 149 ------------VKKDS---------LSCL---------LLSASMDQTILLWEWNVERNK 178

Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366
              LH    H   +  +       T   S   D+ L +W      EE   E++ + P + 
Sbjct: 179 VKALHCCRGHAGSVDSIAVDGSG-TKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKK 237

Query: 367 ------------LFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
                       +    GH   +S   W+  E   ICS S D+ ++VW +
Sbjct: 238 QKTEQLGLTRTPIVTLSGHMEAVSSVLWSDAEE--ICSASWDHTIRVWDV 285



 Score = 36.2 bits (82), Expect = 0.058
 Identities = 32/137 (23%), Positives = 54/137 (39%), Gaps = 16/137 (11%)

Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN--ETILASSGTDRRLN 343
           E+IL TGS DKT  +W L    +   +   H D +  V W   +    +L S+  D+ + 
Sbjct: 112 EWIL-TGSYDKTSRIWSLEGKSIM--TIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTIL 168

Query: 344 VWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403
           +W+           + E    + L    GH   +   + +       CS S D ++++W 
Sbjct: 169 LWEW----------NVERNKVKALHCCRGHAGSVDSIAVD-GSGTKFCSGSWDKMLKIWS 217

Query: 404 MAENIYNDEDPEGSVDP 420
                  DE  E +  P
Sbjct: 218 TVPTDEEDEMEESTNRP 234


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 64/209 (30%), Positives = 92/209 (44%), Gaps = 26/209 (12%)

Query: 195 SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLF-GSVADDQKLM 253
           + SDD T+ +WD     +E        I  GH A V+ V WH     +  GS    Q + 
Sbjct: 219 TCSDDGTVRIWDFLRCHEE-------RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIK 271

Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313
            WD ++  +    H   AH   V  +  N    ++L T S D    L+D+RNLK +L  F
Sbjct: 272 FWDPKTGQSLATLH---AHKNTVMEVKLNLNGNWLL-TASRDHLCKLFDIRNLKEELQVF 327

Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGH 373
             HK E   V W P +E + AS G+D  L  W    +G E+     E G  E+      H
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFW---HVGVEK-----EVGGMEM-----AH 374

Query: 374 TAKISDFSWNPNEPWVICSVSEDNIMQVW 402
              I   +W+P    ++CS S D+  + W
Sbjct: 375 EGMIWSLAWHP-LGHILCSGSNDHTSKFW 402



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/234 (18%), Positives = 101/234 (43%), Gaps = 31/234 (13%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           L+ H      ++W+ N    +L+A     +  W  +        ++   +F  H   + +
Sbjct: 157 LQAHDSPVRAMTWSHN-DMWMLTADHGGYVKYWQSN--------MNNVKMFQAHKEAIRE 207

Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292
            S+    ++ F + +DD  + IWD    +  +    +  H A+V C+ ++P ++ ++ +G
Sbjct: 208 ASFSPT-DNKFATCSDDGTVRIWDFLRCHEER---ILRGHGADVKCVDWHP-TKGLVVSG 262

Query: 293 SAD--KTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350
           S D  + +  WD +  +  L +  +HK+ + +V+ + +   +L +S  D    ++D+  +
Sbjct: 263 SKDSQQPIKFWDPKTGQ-SLATLHAHKNTVMEVKLNLNGNWLLTAS-RDHLCKLFDIRNL 320

Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQM 404
            EE             L +  GH  + +  +W+P    +  S   D  +  W +
Sbjct: 321 KEE-------------LQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHV 361



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 7/82 (8%)

Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233
           RGH+KE   ++W+P   G   S   D ++  W +    + G +  A      H  ++  +
Sbjct: 328 RGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMA------HEGMIWSL 381

Query: 234 SWHLLHESLFGSVADDQKLMIW 255
           +WH L   L  S ++D     W
Sbjct: 382 AWHPLGHILC-SGSNDHTSKFW 402


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)

Query: 172 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230
           R  GH+     ++++P  SGHLL S S D T+ +W    VP    V    T+F  HTA V
Sbjct: 18  RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 68

Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290
             V +    +S F + +DD+ + +W T   +  K   S+  H   V C  F+P    I++
Sbjct: 69  RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 124

Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350
             S DKTV LWD ++ +  +HS+  H   +  V + P + T +A++G D  + VWD+   
Sbjct: 125 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 179

Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
                          LL  +  H+A ++  S++P+  ++I + S D+ +++  + E
Sbjct: 180 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 222



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)

Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252
           ++SASDD T+ LWD S+        +    +  H   V  V +H    +   +   D  +
Sbjct: 122 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 173

Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312
            +WD R   T +       H+A VN LSF+P   +++ T S+D T+ + DL   +L L++
Sbjct: 174 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 228

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
              H+     V +S   E   AS G+D ++ VW
Sbjct: 229 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 260



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 37/154 (24%), Positives = 71/154 (46%), Gaps = 21/154 (13%)

Query: 249 DQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKL 308
           D  LM+W  +  + +   +    H   V C++F+P S  +LA+GS DKTV +W + N+K 
Sbjct: 2   DSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFSP-SGHLLASGSRDKTVRIW-VPNVKG 56

Query: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368
           +   F +H   +  V +    ++ + +S  D+ + VW   +               + LF
Sbjct: 57  ESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTVKVWATHR--------------QKFLF 101

Query: 369 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
               H   +    ++P +  +I S S+D  +++W
Sbjct: 102 SLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 134


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)

Query: 172 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230
           R  GH+     ++++P  SGHLL S S D T+ +W    VP    V    T+F  HTA V
Sbjct: 56  RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 106

Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290
             V +    +S F + +DD+ + +W T   +  K   S+  H   V C  F+P    I++
Sbjct: 107 RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 162

Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350
             S DKTV LWD ++ +  +HS+  H   +  V + P + T +A++G D  + VWD+   
Sbjct: 163 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 217

Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
                          LL  +  H+A ++  S++P+  ++I + S D+ +++  + E
Sbjct: 218 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 260



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)

Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252
           ++SASDD T+ LWD S+        +    +  H   V  V +H    +   +   D  +
Sbjct: 160 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 211

Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312
            +WD R   T +       H+A VN LSF+P   +++ T S+D T+ + DL   +L L++
Sbjct: 212 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 266

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
              H+     V +S   E   AS G+D ++ VW
Sbjct: 267 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 298



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 44/180 (24%), Positives = 82/180 (45%), Gaps = 22/180 (12%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282
           F GH   V  V + +  + L  S + D  LM+W  +  + +   +    H   V C++F+
Sbjct: 15  FKGHRDAVTCVDFSINTKQL-ASGSMDSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFS 70

Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342
           P S  +LA+GS DKTV +W + N+K +   F +H   +  V +    ++ + +S  D+ +
Sbjct: 71  P-SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTV 127

Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
            VW   +               + LF    H   +    ++P +  +I S S+D  +++W
Sbjct: 128 KVWATHR--------------QKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 172


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 32/236 (13%)

Query: 172 RLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVV 230
           R  GH+     ++++P  SGHLL S S D T+ +W    VP    V    T+F  HTA V
Sbjct: 56  RFTGHKDAVTCVNFSP--SGHLLASGSRDKTVRIW----VPN---VKGESTVFRAHTATV 106

Query: 231 EDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILA 290
             V +    +S F + +DD+ + +W T   +  K   S+  H   V C  F+P    I++
Sbjct: 107 RSVHFCSDGQS-FVTASDDKTVKVWAT---HRQKFLFSLSQHINWVRCAKFSPDGRLIVS 162

Query: 291 TGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKI 350
             S DKTV LWD ++ +  +HS+  H   +  V + P + T +A++G D  + VWD+   
Sbjct: 163 A-SDDKTVKLWD-KSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVR-- 217

Query: 351 GEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
                          LL  +  H+A ++  S++P+  ++I + S D+ +++  + E
Sbjct: 218 ------------THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLME 260



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 14/153 (9%)

Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252
           ++SASDD T+ LWD S+        +    +  H   V  V +H    +   +   D  +
Sbjct: 160 IVSASDDKTVKLWDKSS-------RECVHSYCEHGGFVTYVDFH-PSGTCIAAAGMDNTV 211

Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312
            +WD R   T +       H+A VN LSF+P   +++ T S+D T+ + DL   +L L++
Sbjct: 212 KVWDVR---THRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDSTLKILDLMEGRL-LYT 266

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
              H+     V +S   E   AS G+D ++ VW
Sbjct: 267 LHGHQGPATTVAFSRTGE-YFASGGSDEQVMVW 298



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 44/180 (24%), Positives = 82/180 (45%), Gaps = 22/180 (12%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFN 282
           F GH   V  V + +  + L  S + D  LM+W  +  + +   +    H   V C++F+
Sbjct: 15  FKGHRDAVTCVDFSINTKQL-ASGSMDSCLMVWHMKPQSRA---YRFTGHKDAVTCVNFS 70

Query: 283 PYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRL 342
           P S  +LA+GS DKTV +W + N+K +   F +H   +  V +    ++ + +S  D+ +
Sbjct: 71  P-SGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS-DDKTV 127

Query: 343 NVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
            VW   +               + LF    H   +    ++P +  +I S S+D  +++W
Sbjct: 128 KVWATHR--------------QKFLFSLSQHINWVRCAKFSP-DGRLIVSASDDKTVKLW 172


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 13/153 (8%)

Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252
           L+S SDD T+ LW     P E K     T  TGH A++  V +      +  S + D+ +
Sbjct: 52  LVSGSDDFTLFLWS----PAEDK--KPLTRMTGHQALINQVLFSP-DSRIVASASFDKSI 104

Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312
            +WD R   T K   S+  H A V  ++++  S  +L +GS+D T+ +WD++  KL +  
Sbjct: 105 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 159

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
              H DE++ V WSP  + + AS G D+ L +W
Sbjct: 160 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 191



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 39/142 (27%), Positives = 66/142 (46%), Gaps = 23/142 (16%)

Query: 289 LATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLS 348
           L +GS D T+ LW     K  L     H+  I QV +SP +  I+AS+  D+ + +WD  
Sbjct: 52  LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-G 109

Query: 349 KIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW-----Q 403
           + G             + L    GH A +   +W+ +   ++ S S D+ ++VW     +
Sbjct: 110 RTG-------------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQK 155

Query: 404 MAENIYNDEDPEGSVD--PEGQ 423
           +A ++    D   +VD  P+GQ
Sbjct: 156 LAMDLPGHADEVYAVDWSPDGQ 177


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 51/153 (33%), Positives = 80/153 (52%), Gaps = 13/153 (8%)

Query: 193 LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKL 252
           L+S SDD T+ LW     P E K     T  TGH A++  V +      +  S + D+ +
Sbjct: 344 LVSGSDDFTLFLWS----PAEDK--KPLTRMTGHQALINQVLFSP-DSRIVASASFDKSI 396

Query: 253 MIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHS 312
            +WD R   T K   S+  H A V  ++++  S  +L +GS+D T+ +WD++  KL +  
Sbjct: 397 KLWDGR---TGKYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAM-D 451

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
              H DE++ V WSP  + + AS G D+ L +W
Sbjct: 452 LPGHADEVYAVDWSPDGQRV-ASGGKDKCLRIW 483



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 80/314 (25%)

Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSG----HLLSASDDHTICLWDISAVPKEGKVV 217
           DPS        L GH K   GLSW P  +     ++ S+S D ++ +WD +A    G+  
Sbjct: 184 DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTA----GR-- 237

Query: 218 DAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVN 277
             + I TGHT  V  + W    + L  S + D+ + +W        +   ++  H   VN
Sbjct: 238 -CERILTGHTQSVTCLRWG--GDGLLYSASQDRTIKVWRAHDGVLCR---TLQGHGHWVN 291

Query: 278 CL-----------SFNPYSEFI------------------------------LATGSADK 296
            +           +F P    +                              L +GS D 
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDF 351

Query: 297 TVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSP 356
           T+ LW     K  L     H+  I QV +SP +  I+AS+  D+ + +WD  + G     
Sbjct: 352 TLFLWSPAEDKKPLTRMTGHQALINQVLFSP-DSRIVASASFDKSIKLWD-GRTG----- 404

Query: 357 EDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW-----QMAENIYND 411
                   + L    GH A +   +W+ +   ++ S S D+ ++VW     ++A ++   
Sbjct: 405 --------KYLASLRGHVAAVYQIAWSADSR-LLVSGSSDSTLKVWDVKAQKLAMDLPGH 455

Query: 412 EDPEGSVD--PEGQ 423
            D   +VD  P+GQ
Sbjct: 456 ADEVYAVDWSPDGQ 469



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 39/149 (26%), Positives = 71/149 (47%), Gaps = 20/149 (13%)

Query: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317
           R    ++ + S++ H+  V  ++F+P  ++ LA+GS D TV  WDL + +    + + H+
Sbjct: 99  RVRAVTRCTSSLEGHSEAVISVAFSPTGKY-LASGSGDTTVRFWDL-STETPHFTCKGHR 156

Query: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377
             +  + WSP     LAS   + ++ +WD S  G++     A            GH+  I
Sbjct: 157 HWVLSISWSPDGRK-LASGCKNGQILLWDPS-TGKQVGRTLA------------GHSKWI 202

Query: 378 SDFSWNP----NEPWVICSVSEDNIMQVW 402
           +  SW P     E   + S S+D  +++W
Sbjct: 203 TGLSWEPLHANPECRYVASSSKDGSVRIW 231



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 22/87 (25%), Positives = 38/87 (43%), Gaps = 15/87 (17%)

Query: 299 ALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPED 358
           A++ +R +     S E H + +  V +SP  + + + SG D  +  WDLS     ++P  
Sbjct: 96  AIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSG-DTTVRFWDLS----TETPH- 149

Query: 359 AEDGPPELLFIHGGHTAKISDFSWNPN 385
                    F   GH   +   SW+P+
Sbjct: 150 ---------FTCKGHRHWVLSISWSPD 167


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)

Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235
           H+   + L WN     ++LSA  D T  +WD           +AK  F  H+A   DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 328

Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295
              + + F S + D  + +         +P  +   HT EVN + ++P S  +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382

Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 347
            T+ +W ++  ++ +H  ++H  EI+ ++WSP        ++  +LAS+  D  + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 348 SK 349
            +
Sbjct: 442 ER 443



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 229
           LRGH+ E +  +WNP +S  L S S D T  +W+++     G  ++V    I  G   V 
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 230 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285
               V  + W+  + +L  + + D    IW    N  S    ++  H   +  L +N   
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290

Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345

Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  +++W M 
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391

Query: 406 ENI 408
           + +
Sbjct: 392 QEV 394



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 281
           F GHT  V  + W      L  S +DD  L IW  +        H + AH  E+  + + 
Sbjct: 357 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 412

Query: 282 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334
                  NP S  +LA+ S D TV LWD+    +  H+   H++ ++ V +SP  +  LA
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 470

Query: 335 SSGTDRRLNVWD 346
           S   D+ +++W+
Sbjct: 471 SGSFDKCVHIWN 482



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)

Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 226
           P    +GH  E   + W+P  SG LL S SDD T+ +W +   V         K I+T  
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410

Query: 227 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286
            +     + +     +  S + D  + +WD      +   H++  H   V  ++F+P  +
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 467

Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
           + LA+GS DK V +W+ ++  L +HS+      IF+V W+   + +  +S +D  + V D
Sbjct: 468 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 523

Query: 347 LSK 349
           L K
Sbjct: 524 LRK 526



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)

Query: 160 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 193
           K DPSG     C+ D+ L+               H KE Y + W        NPN +  L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253
            SAS D T+ LWDI       + V   T+ T H   V  V++    + L  S + D+ + 
Sbjct: 428 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479

Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304
           IW+T+S N     HS    T  +  + +N   + + A+ S D +V + DLR
Sbjct: 480 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)

Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235
           H+   + L WN     ++LSA  D T  +WD           +AK  F  H+A   DV W
Sbjct: 277 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 328

Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295
              + + F S + D  + +         +P  +   HT EVN + ++P S  +LA+ S D
Sbjct: 329 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 382

Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 347
            T+ +W ++  ++ +H  ++H  EI+ ++WSP        ++  +LAS+  D  + +WD+
Sbjct: 383 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 441

Query: 348 SK 349
            +
Sbjct: 442 ER 443



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 229
           LRGH+ E +  +WNP +S  L S S D T  +W+++     G  ++V    I  G   V 
Sbjct: 177 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 235

Query: 230 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285
               V  + W+  + +L  + + D    IW    N  S    ++  H   +  L +N   
Sbjct: 236 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 290

Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 291 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 345

Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  +++W M 
Sbjct: 346 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 391

Query: 406 ENI 408
           + +
Sbjct: 392 QEV 394



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 281
           F GHT  V  + W      L  S +DD  L IW  +        H + AH  E+  + + 
Sbjct: 357 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 412

Query: 282 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334
                  NP S  +LA+ S D TV LWD+    +  H+   H++ ++ V +SP  +  LA
Sbjct: 413 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 470

Query: 335 SSGTDRRLNVWD 346
           S   D+ +++W+
Sbjct: 471 SGSFDKCVHIWN 482



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)

Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 226
           P    +GH  E   + W+P  SG LL S SDD T+ +W +   V         K I+T  
Sbjct: 353 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 410

Query: 227 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286
            +     + +     +  S + D  + +WD      +   H++  H   V  ++F+P  +
Sbjct: 411 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 467

Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
           + LA+GS DK V +W+ ++  L +HS+      IF+V W+   + +  +S +D  + V D
Sbjct: 468 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 523

Query: 347 LSK 349
           L K
Sbjct: 524 LRK 526



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)

Query: 160 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 193
           K DPSG     C+ D+ L+               H KE Y + W        NPN +  L
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253
            SAS D T+ LWDI       + V   T+ T H   V  V++    + L  S + D+ + 
Sbjct: 428 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 479

Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304
           IW+T+S N     HS    T  +  + +N   + + A+ S D +V + DLR
Sbjct: 480 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 525


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)

Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235
           H+   + L WN     ++LSA  D T  +WD           +AK  F  H+A   DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 379

Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295
              + + F S + D  + +         +P  +   HT EVN + ++P S  +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433

Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 347
            T+ +W ++  ++ +H  ++H  EI+ ++WSP        ++  +LAS+  D  + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 348 SK 349
            +
Sbjct: 493 ER 494



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 229
           LRGH+ E +  +WNP +S  L S S D T  +W+++     G  ++V    I  G   V 
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286

Query: 230 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285
               V  + W+  + +L  + + D    IW    N  S    ++  H   +  L +N   
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341

Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396

Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  +++W M 
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442

Query: 406 ENI 408
           + +
Sbjct: 443 QEV 445



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 281
           F GHT  V  + W      L  S +DD  L IW  +        H + AH  E+  + + 
Sbjct: 408 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 463

Query: 282 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334
                  NP S  +LA+ S D TV LWD+    +  H+   H++ ++ V +SP  +  LA
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 521

Query: 335 SSGTDRRLNVWD 346
           S   D+ +++W+
Sbjct: 522 SGSFDKCVHIWN 533



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)

Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 226
           P    +GH  E   + W+P  SG LL S SDD T+ +W +   V         K I+T  
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 461

Query: 227 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286
            +     + +     +  S + D  + +WD      +   H++  H   V  ++F+P  +
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 518

Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
           + LA+GS DK V +W+ ++  L +HS+      IF+V W+   + +  +S +D  + V D
Sbjct: 519 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 574

Query: 347 LSK 349
           L K
Sbjct: 575 LRK 577



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)

Query: 160 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 193
           K DPSG     C+ D+ L+               H KE Y + W        NPN +  L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478

Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253
            SAS D T+ LWDI       + V   T+ T H   V  V++    + L  S + D+ + 
Sbjct: 479 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530

Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304
           IW+T+S N     HS    T  +  + +N   + + A+ S D +V + DLR
Sbjct: 531 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 23/182 (12%)

Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSW 235
           H+   + L WN     ++LSA  D T  +WD           +AK  F  H+A   DV W
Sbjct: 328 HKGPIFALKWNRK-GNYILSAGVDKTTIIWD-------AHTGEAKQQFPFHSAPALDVDW 379

Query: 236 HLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSAD 295
              + + F S + D  + +         +P  +   HT EVN + ++P S  +LA+ S D
Sbjct: 380 Q--NNTTFASCSTDMCIHVCRL---GCDRPVKTFQGHTNEVNAIKWDP-SGMLLASCSDD 433

Query: 296 KTVALWDLRNLKLKLHSFESHKDEIFQVQWSP--------HNETILASSGTDRRLNVWDL 347
            T+ +W ++  ++ +H  ++H  EI+ ++WSP        ++  +LAS+  D  + +WD+
Sbjct: 434 MTLKIWSMKQ-EVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDI 492

Query: 348 SK 349
            +
Sbjct: 493 ER 494



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 62/243 (25%), Positives = 107/243 (44%), Gaps = 32/243 (13%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTGHTAV- 229
           LRGH+ E +  +WNP +S  L S S D T  +W+++     G  ++V    I  G   V 
Sbjct: 228 LRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 286

Query: 230 ----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYS 285
               V  + W+  + +L  + + D    IW    N  S    ++  H   +  L +N   
Sbjct: 287 SNKDVTSLDWN-TNGTLLATGSYDGFARIWTEDGNLAS----TLGQHKGPIFALKWNRKG 341

Query: 286 EFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
            +IL+ G  DKT  +WD    + K   F  H      V W   N T  AS  TD  ++V 
Sbjct: 342 NYILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDW--QNNTTFASCSTDMCIHV- 396

Query: 346 DLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMA 405
              ++G ++  +  +           GHT +++   W+P+   ++ S S+D  +++W M 
Sbjct: 397 --CRLGCDRPVKTFQ-----------GHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMK 442

Query: 406 ENI 408
           + +
Sbjct: 443 QEV 445



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 14/132 (10%)

Query: 223 FTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSF- 281
           F GHT  V  + W      L  S +DD  L IW  +        H + AH  E+  + + 
Sbjct: 408 FQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQEVCI---HDLQAHNKEIYTIKWS 463

Query: 282 -------NPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA 334
                  NP S  +LA+ S D TV LWD+    +  H+   H++ ++ V +SP  +  LA
Sbjct: 464 PTGPATSNPNSNIMLASASFDSTVRLWDIER-GVCTHTLTKHQEPVYSVAFSPDGK-YLA 521

Query: 335 SSGTDRRLNVWD 346
           S   D+ +++W+
Sbjct: 522 SGSFDKCVHIWN 533



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 50/183 (27%), Positives = 86/183 (46%), Gaps = 11/183 (6%)

Query: 169 PDLRLRGHQKEGYGLSWNPNLSGHLL-SASDDHTICLWDISA-VPKEGKVVDAKTIFTGH 226
           P    +GH  E   + W+P  SG LL S SDD T+ +W +   V         K I+T  
Sbjct: 404 PVKTFQGHTNEVNAIKWDP--SGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIK 461

Query: 227 TAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSE 286
            +     + +     +  S + D  + +WD      +   H++  H   V  ++F+P  +
Sbjct: 462 WSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCT---HTLTKHQEPVYSVAFSPDGK 518

Query: 287 FILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
           + LA+GS DK V +W+ ++  L +HS+      IF+V W+   + +  +S +D  + V D
Sbjct: 519 Y-LASGSFDKCVHIWNTQSGNL-VHSYRG-TGGIFEVCWNARGDKV-GASASDGSVCVLD 574

Query: 347 LSK 349
           L K
Sbjct: 575 LRK 577



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 51/171 (29%), Positives = 75/171 (43%), Gaps = 39/171 (22%)

Query: 160 KPDPSG----ECNPDLRLR--------------GHQKEGYGLSW--------NPNLSGHL 193
           K DPSG     C+ D+ L+               H KE Y + W        NPN +  L
Sbjct: 419 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 478

Query: 194 LSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLM 253
            SAS D T+ LWDI       + V   T+ T H   V  V++    + L  S + D+ + 
Sbjct: 479 ASASFDSTVRLWDIE------RGVCTHTL-TKHQEPVYSVAFSPDGKYL-ASGSFDKCVH 530

Query: 254 IWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304
           IW+T+S N     HS    T  +  + +N   + + A+ S D +V + DLR
Sbjct: 531 IWNTQSGNL---VHSYRG-TGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 576


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 51/188 (27%), Positives = 90/188 (47%), Gaps = 15/188 (7%)

Query: 212 KEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWD----TRSNNTSKPSH 267
           K G+V     + TGHTA V D+ W   ++++  S +DD  +M+W     T   N ++P  
Sbjct: 66  KTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPII 125

Query: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327
           +++ H+  V  LS++P +  +L +   D  + +W++   ++ L   + H D I  V W+ 
Sbjct: 126 TLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWN- 184

Query: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGGH--TAKISDFS-- 381
            N ++LA++  D+ L + D  K         A +G  P   +F   GH  T   +  S  
Sbjct: 185 SNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244

Query: 382 ----WNPN 385
               W+PN
Sbjct: 245 ELGLWDPN 252



 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 47/198 (23%), Positives = 81/198 (40%), Gaps = 10/198 (5%)

Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234
           GH      + W P+    + SASDD TI +W I        + +      GH+  V  +S
Sbjct: 79  GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILS 138

Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294
           WH    ++  S   D  ++IW+  +          D H   ++ + +N     +LAT   
Sbjct: 139 WHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLD--DMHPDVIHSVCWNSNGS-LLATTCK 195

Query: 295 DKTVALWDLRNLKLKLHSFESHKD-----EIFQVQWSPHNETILASSGTDRRLNVWDLSK 349
           DKT+ + D R  ++    F +H+       +F  Q   H  T   +  + R L +WD + 
Sbjct: 196 DKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQ--GHIFTTGFTRMSQRELGLWDPNN 253

Query: 350 IGEEQSPEDAEDGPPELL 367
             E  + ++ +     LL
Sbjct: 254 FEEPVALQEMDTSNGVLL 271



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 48/191 (25%), Positives = 79/191 (41%), Gaps = 21/191 (10%)

Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVF---DYTKHPSKPDPSGECNPDLRLRGHQKE 179
           H   V    + P N  +IA+ +  + ++V+   DYT   +  +P       + L GH K 
Sbjct: 80  HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPI------ITLEGHSKR 133

Query: 180 GYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 239
              LSW+P     LLSA  D+ I +W++      G+V+   ++   H  V+  V W+  +
Sbjct: 134 VGILSWHPTARNVLLSAGGDNVIIIWNVGT----GEVL--LSLDDMHPDVIHSVCWN-SN 186

Query: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG---SADK 296
            SL  +   D+ L I D R       +    AH       +       I  TG    + +
Sbjct: 187 GSLLATTCKDKTLRIIDPRKGQV--VAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMSQR 244

Query: 297 TVALWDLRNLK 307
            + LWD  N +
Sbjct: 245 ELGLWDPNNFE 255



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 7/89 (7%)

Query: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTA 375
           H   +  + W PHN+ ++AS+  D  + VW +      ++         E +    GH+ 
Sbjct: 80  HTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNIT-------EPIITLEGHSK 132

Query: 376 KISDFSWNPNEPWVICSVSEDNIMQVWQM 404
           ++   SW+P    V+ S   DN++ +W +
Sbjct: 133 RVGILSWHPTARNVLLSAGGDNVIIIWNV 161



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 15/35 (42%), Positives = 21/35 (60%)

Query: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
           GHTA + D  W P+   VI S S+D  + VWQ+ +
Sbjct: 79  GHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPD 113


>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
           sapiens]
          Length = 731

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)

Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242
           +SW+      L S+  + T+ LWD       G       ++  H      V ++L+   L
Sbjct: 476 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 528

Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302
             S +DD K+ +W T  +N+     S++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 529 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 584

Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349
           LRN K  +  F+ H+  +   ++    E + AS  TD +L +W++ K
Sbjct: 585 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 629



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 332
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 471 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 528

Query: 333 LASSGTDRRLNVW 345
           LAS   D ++ +W
Sbjct: 529 LASGSDDAKVKLW 541


>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
           sapiens]
          Length = 707

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)

Query: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242
           +SW+      L S+  + T+ LWD       G       ++  H      V ++L+   L
Sbjct: 452 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504

Query: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302
             S +DD K+ +W T  +N+     S++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 505 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560

Query: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349
           LRN K  +  F+ H+  +   ++    E + AS  TD +L +W++ K
Sbjct: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 274 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 332
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504

Query: 333 LASSGTDRRLNVW 345
           LAS   D ++ +W
Sbjct: 505 LASGSDDAKVKLW 517


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 65/219 (29%), Positives = 106/219 (48%), Gaps = 35/219 (15%)

Query: 188 NLSGH-LLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSV 246
           N SG   ++ S D T  LWD ++    G+ ++      GH  VV  ++++  +     + 
Sbjct: 101 NKSGSCFITGSYDRTCKLWDTAS----GEELNT---LEGHRNVVYAIAFNNPYGDKIATG 153

Query: 247 ADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNL 306
           + D+   +W   S  T K  H+   HTAE+ CLSFNP S  ++ATGS D T  LWD++N 
Sbjct: 154 SFDKTCKLW---SVETGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNG 209

Query: 307 KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPEL 366
           + ++++   H  EI  + ++   + I+  S  D  + VW            DA+ G    
Sbjct: 210 E-EVYTLRGHSAEIISLSFNTSGDRIITGS-FDHTVVVW------------DADTGRKVN 255

Query: 367 LFIHGGHTAKISDFSWNPNEPW---VICSVSEDNIMQVW 402
           + I  GH A+IS  S+N    W   +I + S D   ++W
Sbjct: 256 ILI--GHCAEISSASFN----WDCSLILTGSMDKTCKLW 288



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 64/233 (27%), Positives = 102/233 (43%), Gaps = 38/233 (16%)

Query: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT--GHTAVVE 231
           RGH  E   LS+NP  S  + + S D T  LWDI          + + ++T  GH+A + 
Sbjct: 174 RGHTAEIVCLSFNPQ-STLVATGSMDTTAKLWDIQ---------NGEEVYTLRGHSAEII 223

Query: 232 DVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILAT 291
            +S++   + +    + D  +++WD    +T +  + +  H AE++  SFN     IL T
Sbjct: 224 SLSFNTSGDRIITG-SFDHTVVVWDA---DTGRKVNILIGHCAEISSASFNWDCSLIL-T 278

Query: 292 GSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASS--GTDRRLNVWDLSK 349
           GS DKT  LWD  N K  + +   H DEI    +    + I  +S  GT R  +      
Sbjct: 279 GSMDKTCKLWDATNGKC-VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337

Query: 350 IGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
           I + +                 GH  +IS  S+NP    ++   S D   ++W
Sbjct: 338 IAKLE-----------------GHEGEISKISFNPQGNHLLTG-SSDKTARIW 372



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 53/212 (25%), Positives = 86/212 (40%), Gaps = 51/212 (24%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           LRGH  E   LS+N +    +++ S DHT+ +WD       G+ V+   I  GH A +  
Sbjct: 215 LRGHSAEIISLSFNTS-GDRIITGSFDHTVVVWDADT----GRKVN---ILIGHCAEISS 266

Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNN------------------------------- 261
            S++    SL  + + D+   +WD  +                                 
Sbjct: 267 ASFNW-DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325

Query: 262 --------TSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSF 313
                   T K    ++ H  E++ +SFNP    +L TGS+DKT  +WD +  +  L   
Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLL-TGSSDKTARIWDAQTGQC-LQVL 383

Query: 314 ESHKDEIFQVQWSPHNETILASSGTDRRLNVW 345
           E H DEIF   ++ +   I+ +   D    +W
Sbjct: 384 EGHTDEIFSCAFN-YKGNIVITGSKDNTCRIW 414



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 48/174 (27%), Positives = 82/174 (47%), Gaps = 14/174 (8%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232
           L GH+   Y +++N      + + S D T  LW +    + GK       F GHTA +  
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV----ETGKCYHT---FRGHTAEIVC 182

Query: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292
           +S++    +L  + + D    +WD ++    +  +++  H+AE+  LSFN   + I+ TG
Sbjct: 183 LSFN-PQSTLVATGSMDTTAKLWDIQN---GEEVYTLRGHSAEIISLSFNTSGDRII-TG 237

Query: 293 SADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
           S D TV +WD  +   K++    H  EI    ++     IL  S  D+   +WD
Sbjct: 238 SFDHTVVVWD-ADTGRKVNILIGHCAEISSASFNWDCSLILTGS-MDKTCKLWD 289



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 15/35 (42%), Positives = 21/35 (60%), Gaps = 1/35 (2%)

Query: 172 RLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWD 206
           +L GH+ E   +S+NP    HLL+ S D T  +WD
Sbjct: 340 KLEGHEGEISKISFNPQ-GNHLLTGSSDKTARIWD 373


>gi|58331266 WD repeat domain 59 [Homo sapiens]
          Length = 974

 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 17/187 (9%)

Query: 168 NPDLRLRGHQKEGY-------GLSWNPNLS-GHLLSASDDHTICLWDISAVPKEGKVVDA 219
           N D    GH+K           + WNP+ S  H  +AS +  + L+      K+G   + 
Sbjct: 43  NLDAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW----KDGSG-EV 97

Query: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCL 279
            T   GHT V+ D+ W +    L  + + D  + IWD +  +T KP+ ++ A  A  + +
Sbjct: 98  GTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIK--DTRKPTVALSA-VAGASQV 154

Query: 280 SFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTD 339
            +N  +   LAT S D  V +WD R     +    +H  +I  + W P +E ILA+S  D
Sbjct: 155 KWNKKNANCLAT-SHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQD 213

Query: 340 RRLNVWD 346
             +  WD
Sbjct: 214 NSVKFWD 220



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 62/260 (23%), Positives = 95/260 (36%), Gaps = 69/260 (26%)

Query: 162 DPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKT 221
           D SGE    L+  GH +    L W       L+++S D  I +WDI    K        T
Sbjct: 92  DGSGEVGTTLQ--GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKP-------T 142

Query: 222 IFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVD---AHTAEVNC 278
           +     A    V W+  + +   + + D  + IWD R     KPS +V+   AH ++++ 
Sbjct: 143 VALSAVAGASQVKWNKKNANCLAT-SHDGDVRIWDKR-----KPSTAVEYLAAHLSKIHG 196

Query: 279 LSFNPYSEFILATGSADKTVALWDLR---------------------------------- 304
           L ++P SE ILAT S D +V  WD R                                  
Sbjct: 197 LDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQ 256

Query: 305 -------------NLKLKLHSFESHKDEIFQVQWSPHNETI----LASSGTDRRLNVWDL 347
                        +L   +H+F  H D + + QW    E      L +   D+ L +W +
Sbjct: 257 LRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRKQKEGSKDYQLVTWSRDQTLRMWRV 316

Query: 348 SKIGEEQSPEDAEDGPPELL 367
               +     D  DG  E +
Sbjct: 317 DSQMQRLCANDILDGVDEFI 336



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 29/104 (27%), Positives = 42/104 (40%), Gaps = 24/104 (23%)

Query: 313 FESHKD-------EIFQVQWSPHNET---ILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362
           FE H+        +I  VQW+PH+       ASS     L  W              +DG
Sbjct: 48  FEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKW--------------KDG 93

Query: 363 PPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAE 406
             E+     GHT  ISD  W   EP ++ + S D  + +W + +
Sbjct: 94  SGEVGTTLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD 137


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 62/283 (21%), Positives = 114/283 (40%), Gaps = 63/283 (22%)

Query: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234
           GHQ+    ++W+P    +L SAS D T C+W      K     +  T   GH   V+ V+
Sbjct: 59  GHQRTVRKVAWSP-CGNYLASASFDATTCIWK-----KNQDDFECVTTLEGHENEVKSVA 112

Query: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSA 294
           W     +L  + + D+ + +W+    +  +    +++HT +V  + ++P S+ +LA+ S 
Sbjct: 113 W-APSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP-SQELLASASY 170

Query: 295 DKTVALW-DLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEE 353
           D TV L+ +  +  +   + E H+  ++ + + P  +  LAS   DR + +W     G E
Sbjct: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQR-LASCSDDRTVRIWRQYLPGNE 229

Query: 354 QS------------------------------------------------PEDAEDGPPE 365
           Q                                                  ED    P +
Sbjct: 230 QGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQ 289

Query: 366 LLF-----IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQ 403
             F     +H  H+  ++  +WNP EP ++ S S+D  +  W+
Sbjct: 290 PTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 15/143 (10%)

Query: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLW------DISAVPKEGKVVDAKTIFT-- 224
           L GH+   + L+++P+    L S SDD T+ +W      +   V   G     K I T  
Sbjct: 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248

Query: 225 -GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV-----DAHTAEVNC 278
             H+  + D++W  L  +L  +  DD   +  +  +++  +P+ S+      AH+ +VNC
Sbjct: 249 GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNC 308

Query: 279 LSFNPYSEFILATGSADKTVALW 301
           +++NP    +LA+ S D  VA W
Sbjct: 309 VAWNPKEPGLLASCSDDGEVAFW 331



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 40/186 (21%), Positives = 77/186 (41%), Gaps = 34/186 (18%)

Query: 241 SLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVAL 300
           +L  S   D+++ IW T  ++    S   + H   V  ++++P   + LA+ S D T  +
Sbjct: 29  TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY-LASASFDATTCI 87

Query: 301 WDLRNLKLK-LHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359
           W       + + + E H++E+  V W+P    +LA+   D+ + VW++            
Sbjct: 88  WKKNQDDFECVTTLEGHENEVKSVAWAPSGN-LLATCSRDKSVWVWEVD----------- 135

Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEP--------------------WVICSVSEDNIM 399
           E+   E + +   HT  +    W+P++                     WV C+  E +  
Sbjct: 136 EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195

Query: 400 QVWQMA 405
            VW +A
Sbjct: 196 TVWSLA 201


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 75/283 (26%), Positives = 120/283 (42%), Gaps = 45/283 (15%)

Query: 123 HEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYG 182
           H GEVN + + P    ++   T S D  V+ +         SG+     RL GH      
Sbjct: 20  HGGEVNSSAFSPDGQMLL---TGSEDGCVYGWETR------SGQLL--WRLGGHTGPVKF 68

Query: 183 LSWNPNLSGHLL-SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHES 241
             ++P+  GHL  SAS D T+ LWD++             +  GH   VE VS+      
Sbjct: 69  CRFSPD--GHLFASASCDCTVRLWDVARAK-------CLRVLKGHQRSVETVSFSPDSRQ 119

Query: 242 LFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALW 301
           L  S   D+++M+WD +S    +    +  H   +    F+P     LATGS D TV +W
Sbjct: 120 L-ASGGWDKRVMLWDVQSGQMLR---LLVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIW 174

Query: 302 DLRNL--KLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDA 359
           DLR +   +   + E H   I  + +S     +LAS   D+ +++W              
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIW-------------- 218

Query: 360 EDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402
           +     LL    GH   +   +++P+E W + S     +++VW
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELW-LASAGYSRMVKVW 260



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 65/248 (26%), Positives = 118/248 (47%), Gaps = 27/248 (10%)

Query: 100 SEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPS 159
           SE G   G+ + SG++   +   H G V   R+ P    + A+ +    V ++D  +   
Sbjct: 40  SEDGCVYGWETRSGQLLWRLG-GHTGPVKFCRFSPDGH-LFASASCDCTVRLWDVAR--- 94

Query: 160 KPDPSGECNPDLR-LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVD 218
                 +C   LR L+GHQ+    +S++P+ S  L S   D  + LWD+ +    G+++ 
Sbjct: 95  -----AKC---LRVLKGHQRSVETVSFSPD-SRQLASGGWDKRVMLWDVQS----GQML- 140

Query: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278
              +  GH   ++   +      L  + + D  + IWD R    +    +++ H+A ++C
Sbjct: 141 --RLLVGHRDSIQSSDFSPTVNCL-ATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197

Query: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGT 338
           L ++  +  +LA+GS DKT+ +W      L L   + H   +  + +SP +E  LAS+G 
Sbjct: 198 LCYS--ASGLLASGSWDKTIHIWKPTTSSL-LIQLKGHVTWVKSIAFSP-DELWLASAGY 253

Query: 339 DRRLNVWD 346
            R + VWD
Sbjct: 254 SRMVKVWD 261


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 32/247 (12%)

Query: 168 NPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEG--KVVDAKTIFTG 225
           N  + LRGH+ E +  +WNP +S  L S S D T  +W++S     G  ++V    I  G
Sbjct: 160 NKAVVLRGHESEVFICAWNP-VSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREG 218

Query: 226 HTAV-----VEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLS 280
              V     V  + W+    +L  + + D    IW    N  S    ++  H   +  L 
Sbjct: 219 GQDVPSNKDVTSLDWN-SEGTLLATGSYDGFARIWTKDGNLAS----TLGQHKGPIFALK 273

Query: 281 FNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR 340
           +N    FIL+ G  DKT  +WD    + K   F  H      V W  +N    AS  TD 
Sbjct: 274 WNKKGNFILSAG-VDKTTIIWDAHTGEAK-QQFPFHSAPALDVDWQSNN--TFASCSTDM 329

Query: 341 RLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQ 400
            ++V    K+G+++  +  +           GHT +++   W+P    ++ S S+D  ++
Sbjct: 330 CIHV---CKLGQDRPIKTFQ-----------GHTNEVNAIKWDPTGN-LLASCSDDMTLK 374

Query: 401 VWQMAEN 407
           +W M ++
Sbjct: 375 IWSMKQD 381



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 55/214 (25%), Positives = 87/214 (40%), Gaps = 51/214 (23%)

Query: 176 HQKEGYGLSWNPNLSGHLLSASDDHTICLWDISA-------------------------- 209
           H+   + L WN      +LSA  D T  +WD                             
Sbjct: 265 HKGPIFALKWNKK-GNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFA 323

Query: 210 ---------VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSN 260
                    V K G+    KT F GHT  V  + W     +L  S +DD  L IW  + +
Sbjct: 324 SCSTDMCIHVCKLGQDRPIKT-FQGHTNEVNAIKWDPTG-NLLASCSDDMTLKIWSMKQD 381

Query: 261 NTSKPSHSVDAHTAEVNCLSF--------NPYSEFILATGSADKTVALWDLRNLKLKLHS 312
           N     H + AH  E+  + +        NP +  +LA+ S D TV LWD+ +  + +H+
Sbjct: 382 NCV---HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV-DRGICIHT 437

Query: 313 FESHKDEIFQVQWSPHNETILASSGTDRRLNVWD 346
              H++ ++ V +SP     LAS   D+ +++W+
Sbjct: 438 LTKHQEPVYSVAFSPDGR-YLASGSFDKCVHIWN 470



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 46/185 (24%), Positives = 70/185 (37%), Gaps = 65/185 (35%)

Query: 173 LRGHQKEGYGLSW--------NPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFT 224
           L+ H KE Y + W        NPN +  L SAS D T+ LWD+                 
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVD---------------- 430

Query: 225 GHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPY 284
                   +  H L                         +P +SV          +F+P 
Sbjct: 431 ------RGICIHTL---------------------TKHQEPVYSV----------AFSPD 453

Query: 285 SEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNV 344
             + LA+GS DK V +W+ +   L +HS+      IF+V W+   + +  +S +D  + V
Sbjct: 454 GRY-LASGSFDKCVHIWNTQTGAL-VHSYRG-TGGIFEVCWNAAGDKV-GASASDGSVCV 509

Query: 345 WDLSK 349
            DL K
Sbjct: 510 LDLRK 514


>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
           sapiens]
          Length = 387

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 45/328 (13%)

Query: 108 FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIAT---KTPSSDVLV----------FDY 154
           F   +  I   + ++  GE+      P +  ++ T   +T  S VL            + 
Sbjct: 48  FDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELES 107

Query: 155 TKHPSKPDPSGECNPDLRLRGH-QKEGYG----LSWNPNLSGHLLSASDDHTICLWDISA 209
             H S PD S      L L  H     +G    + W P   G  + +  D+ I LWD+  
Sbjct: 108 GSHES-PDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQE 166

Query: 210 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 269
              +  +  + ++            W   H     + A+D  L  WDTRS   S+     
Sbjct: 167 SSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRS--MSQIYCIE 224

Query: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 329
           +AH   V  L FNP  ++ LA+   D  V  WD RN+   + + E H   ++ V+++  +
Sbjct: 225 NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH 284

Query: 330 ETILASSGTDRRLNVWDLSKI---------------------GEEQSPEDAEDGPPELLF 368
           + ++ +  +D R+ + ++  I                      EE+S E  +D    ++ 
Sbjct: 285 DQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQD---NVIA 341

Query: 369 IHGGHTAKISDFSWNPNEPWVICSVSED 396
            +  H   +    W+  +PW+  S+S D
Sbjct: 342 TYEEHEDSVYAVDWSSADPWLFASLSYD 369



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 39/189 (20%)

Query: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 244
           W+P+ +   ++ ++D T+  WD  ++ +   + +A      H  +V D+ ++   +    
Sbjct: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA------HGQLVRDLDFNPNKQYYLA 245

Query: 245 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304
           S  DD K+  WDTR  N ++P  +++ H+  V  + +N   + ++ TGS+D  V L ++ 
Sbjct: 246 SCGDDCKVKFWDTR--NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMV 303

Query: 305 NLKLK-------------------------------LHSFESHKDEIFQVQWSPHNETIL 333
           ++  +                               + ++E H+D ++ V WS  +  + 
Sbjct: 304 SISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLF 363

Query: 334 ASSGTDRRL 342
           AS   D RL
Sbjct: 364 ASLSYDGRL 372



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 42/208 (20%), Positives = 74/208 (35%), Gaps = 27/208 (12%)

Query: 204 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVS-WHLLHESLFGS--VADDQKLMIWDTRSN 260
           +W ISA P +  V+      T  + V+   + W +  E   GS    DD       + + 
Sbjct: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121

Query: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 319
                 H  +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181

Query: 320 -----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374
                    +WSPH+     ++  D  L  WD   + +             +  I   H 
Sbjct: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-------------IYCIENAHG 228

Query: 375 AKISDFSWNPNEPWVICSVSEDNIMQVW 402
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,477,037
Number of Sequences: 37866
Number of extensions: 873042
Number of successful extensions: 3197
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 1720
Number of HSP's gapped (non-prelim): 927
length of query: 425
length of database: 18,247,518
effective HSP length: 105
effective length of query: 320
effective length of database: 14,271,588
effective search space: 4566908160
effective search space used: 4566908160
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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