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Search of human proteins with 5031707
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
(662 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 1303 0.0
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 1303 0.0
gi|38348406 leucine rich repeat containing 33 [Homo sapiens] 311 2e-84
gi|225579152 insulin-like growth factor binding protein, acid la... 134 2e-31
gi|4826772 insulin-like growth factor binding protein, acid labi... 134 2e-31
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 121 2e-27
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 121 2e-27
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 119 1e-26
gi|4759146 slit homolog 2 [Homo sapiens] 118 2e-26
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 115 1e-25
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 115 1e-25
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 114 4e-25
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 113 5e-25
gi|45505137 podocan [Homo sapiens] 112 8e-25
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 112 1e-24
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 112 1e-24
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 112 1e-24
gi|20302168 toll-like receptor 8 [Homo sapiens] 110 3e-24
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 110 4e-24
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 108 2e-23
gi|11321571 slit homolog 3 [Homo sapiens] 108 2e-23
gi|4507531 toll-like receptor 3 [Homo sapiens] 105 1e-22
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 105 2e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 104 2e-22
gi|12007646 nyctalopin precursor [Homo sapiens] 103 7e-22
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 102 9e-22
gi|194440719 chondroadherin-like [Homo sapiens] 102 1e-21
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 101 3e-21
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 101 3e-21
gi|188528675 slit homolog 1 [Homo sapiens] 98 3e-20
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 1303 bits (3372), Expect = 0.0
Identities = 662/662 (100%), Positives = 662/662 (100%)
Query: 1 MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ
Sbjct: 1 MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
Query: 61 LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL
Sbjct: 61 LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL
Sbjct: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ
Sbjct: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
Query: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL
Sbjct: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
Query: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
Sbjct: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
Query: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN
Sbjct: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
Sbjct: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC
Sbjct: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
Query: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY
Sbjct: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
Query: 661 KA 662
KA
Sbjct: 661 KA 662
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 1303 bits (3372), Expect = 0.0
Identities = 662/662 (100%), Positives = 662/662 (100%)
Query: 1 MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ
Sbjct: 1 MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
Query: 61 LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL
Sbjct: 61 LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL
Sbjct: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ
Sbjct: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ 240
Query: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL
Sbjct: 241 AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL 300
Query: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
Sbjct: 301 PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG 360
Query: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN
Sbjct: 361 SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
Sbjct: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE 480
Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV
Sbjct: 481 VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV 540
Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC
Sbjct: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC 600
Query: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY
Sbjct: 601 RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY 660
Query: 661 KA 662
KA
Sbjct: 661 KA 662
>gi|38348406 leucine rich repeat containing 33 [Homo sapiens]
Length = 692
Score = 311 bits (796), Expect = 2e-84
Identities = 242/653 (37%), Positives = 325/653 (49%), Gaps = 43/653 (6%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
CK+V C+ L VPS LPP L L N L+++ L Y L L L + +
Sbjct: 34 CKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHL 93
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
+ GAFQ HL L L N L+ +A L LP + LDLSGN+L + +L
Sbjct: 94 ERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALML 153
Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
SL ++SLA N++ RL F + L +LDL N + +IE GAF+GL L HLNL+
Sbjct: 154 QNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLA 213
Query: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
N+L CI DF L +LRVL++S N +E F A+ +A F+L LDL N+LL FP L
Sbjct: 214 FNNLPCIVDFGLTRLRVLNVSYNVLEWF-LATGGEAAFELETLDLSHNQLLFFPLLPQYS 272
Query: 266 RLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA------------SGRP 313
+L L L +N + G +D +P E + L GN S
Sbjct: 273 KLRTLLLRDNNM----GFYRDLYNTSSPREMVAQFLL--VDGNVTNITTVSLWEEFSSSD 326
Query: 314 LSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
L+ L LD+S N+ + +PD FL + SL LNL +NCL T R L LDLSHN
Sbjct: 327 LADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHN 386
Query: 374 ALETLELG---ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP-- 428
L L L A LGSLR L N L +PP FAN ++ L++ N++S C P
Sbjct: 387 QLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAA 446
Query: 429 -DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALG 487
D GP CV F + SLRSLSL + L F T LT LDLSSN G V G+L
Sbjct: 447 SDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWG--VLNGSLA 504
Query: 488 GLE---ASLEVLALQGNGL--MVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLD 542
L+ L+VL+L+ GL + +D F L+ L+L+ N L+ P + +++LE LD
Sbjct: 505 PLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLD 564
Query: 543 LRNNSFSLLPGSAMG-GLETSLRRLYLQGNPLSCCG-NGWLAAQLHQGRVDVDATQDLIC 600
LR NS + LP A+ L LR +YL NP CCG +GW A L G+ D + C
Sbjct: 565 LRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGA--LQHGQTVADWAM-VTC 621
Query: 601 RFSSQ--EEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCV 651
SS+ L P DC+ L + +L +L+ LT L AC +
Sbjct: 622 NLSSKIIRVTELPGGVPRDCKWERLD----LGLLYLVLILPSCLTLLVACTVI 670
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 134 bits (338), Expect = 2e-31
Identities = 176/557 (31%), Positives = 226/557 (40%), Gaps = 88/557 (15%)
Query: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
V C L ++P +P T+ L L GN L S+ P A
Sbjct: 96 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV------------------------PPAA 131
Query: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
FQ L+ L L+L +L G L P + LLG H
Sbjct: 132 FQNLSSLGFLNLQGGQL--------GSLEP-------------------QALLGLENLCH 164
Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
L L N L L TF PAL L L +N L +EDG FEGL L LNL NSL +
Sbjct: 165 -LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223
Query: 213 SDFS---LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFPDLAALPRL 267
D + L LR L L+ N + Q A +L LDL N L + LPRL
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALF-SGLAELRELDLSRNALRAIKANVFVQLPRL 282
Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG--NASGRPLSQLLNLDLSYN 325
L L NLI P G+ A W L + +G + L L L LS+N
Sbjct: 283 QKLYLDRNLIAAVA--PGAFLGLKALR--WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338
Query: 326 EIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RA 384
I + + L L L L N +R R L L +L L HN L+ ++ GA
Sbjct: 339 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398
Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITS 444
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLSG 449
Query: 445 LRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL 503
LR L L DN + + + L ELDL+SN + GL LE L L N L
Sbjct: 450 LRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNRL 508
Query: 504 MVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMGG 558
L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 509 AELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG- 565
Query: 559 LETSLRRLYLQGNPLSC 575
L RL+L+GNP C
Sbjct: 566 ----LERLWLEGNPWDC 578
Score = 121 bits (304), Expect = 2e-27
Identities = 136/426 (31%), Positives = 184/426 (43%), Gaps = 60/426 (14%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
L L NQLRS+ AL L LS N +S L+ G F+ L L L+L N LA+
Sbjct: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 224
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
+ GLG L L L+GN L + L L L L L+ N+L + + F +P
Sbjct: 225 DAAFRGLGSL---RELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280
Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSI 230
L++L L N++ + GAF GL L L+LS N + + + + L LRVL LS N+I
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340
Query: 231 EAFQTASQPQAEF-----------------------QLTWLDLRENKLLHFPDLA--ALP 265
+ + + F QL L L N+L A L
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400
Query: 266 RLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAP------SG----------- 307
+ +NLS N +R LP + +H+ S L P SG
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 308 ----NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
S L++LL LDL+ N++ +P + L L +L LSRN L A LG L
Sbjct: 461 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 520
Query: 364 CLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
LD+SHN LE L A LG LR L L+ N+LR P L+RL L+GN
Sbjct: 521 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 576
Query: 423 SPCGGP 428
CG P
Sbjct: 577 D-CGCP 581
Score = 100 bits (248), Expect = 6e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
S GLG L V ++LSGN L L E++ LH
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 427
Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
Query: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 546
Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
YL+L NN +R T P + + W PL A
Sbjct: 547 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 584
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 134 bits (338), Expect = 2e-31
Identities = 176/557 (31%), Positives = 226/557 (40%), Gaps = 88/557 (15%)
Query: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
V C L ++P +P T+ L L GN L S+ P A
Sbjct: 58 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV------------------------PPAA 93
Query: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
FQ L+ L L+L +L G L P + LLG H
Sbjct: 94 FQNLSSLGFLNLQGGQL--------GSLEP-------------------QALLGLENLCH 126
Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
L L N L L TF PAL L L +N L +EDG FEGL L LNL NSL +
Sbjct: 127 -LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
Query: 213 SDFS---LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFPDLAALPRL 267
D + L LR L L+ N + Q A +L LDL N L + LPRL
Sbjct: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALF-SGLAELRELDLSRNALRAIKANVFVQLPRL 244
Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG--NASGRPLSQLLNLDLSYN 325
L L NLI P G+ A W L + +G + L L L LS+N
Sbjct: 245 QKLYLDRNLIAAVA--PGAFLGLKALR--WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
Query: 326 EIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RA 384
I + + L L L L N +R R L L +L L HN L+ ++ GA
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITS 444
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLSG 411
Query: 445 LRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL 503
LR L L DN + + + L ELDL+SN + GL LE L L N L
Sbjct: 412 LRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNRL 470
Query: 504 MVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMGG 558
L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 471 AELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG- 527
Query: 559 LETSLRRLYLQGNPLSC 575
L RL+L+GNP C
Sbjct: 528 ----LERLWLEGNPWDC 540
Score = 121 bits (304), Expect = 2e-27
Identities = 136/426 (31%), Positives = 184/426 (43%), Gaps = 60/426 (14%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
L L NQLRS+ AL L LS N +S L+ G F+ L L L+L N LA+
Sbjct: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
+ GLG L L L+GN L + L L L L L+ N+L + + F +P
Sbjct: 187 DAAFRGLGSL---RELVLAGNRL-AYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSI 230
L++L L N++ + GAF GL L L+LS N + + + + L LRVL LS N+I
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
Query: 231 EAFQTASQPQAEF-----------------------QLTWLDLRENKLLHFPDLA--ALP 265
+ + + F QL L L N+L A L
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
Query: 266 RLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAP------SG----------- 307
+ +NLS N +R LP + +H+ S L P SG
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 308 ----NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
S L++LL LDL+ N++ +P + L L +L LSRN L A LG L
Sbjct: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
Query: 364 CLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
LD+SHN LE L A LG LR L L+ N+LR P L+RL L+GN
Sbjct: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPW 538
Query: 423 SPCGGP 428
CG P
Sbjct: 539 D-CGCP 543
Score = 100 bits (248), Expect = 6e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
S GLG L V ++LSGN L L E++ LH
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389
Query: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
Query: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508
Query: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
YL+L NN +R T P + + W PL A
Sbjct: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 121 bits (303), Expect = 2e-27
Identities = 136/456 (29%), Positives = 192/456 (42%), Gaps = 77/456 (16%)
Query: 32 KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
+V C ++ VP+ LP + +L + + + SP +AL L + NE+S + PG
Sbjct: 42 QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPG 101
Query: 92 AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSL 151
AF+ L L +LSLA+N+L + L+ GL SL
Sbjct: 102 AFRNLGSLRYLSLANNKLQVLPI--------------------GLFQGL--------DSL 133
Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
+L L+ N L ++ F L++L LH N L I DGAF+ L LT LNL +NSLT
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 193
Query: 212 ISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP--DLAALPRLIY 269
IS Q L L + L L EN+L P L L
Sbjct: 194 ISPRVFQHLGNLQV----------------------LRLYENRLTDIPMGTFDGLVNLQE 231
Query: 270 LNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP------LSQLLNLDLS 323
L L N I L S G+ + L LS + + S P L QL L L
Sbjct: 232 LALQQNQIGLL------SPGLFHNNHNLQRLYLS--NNHISQLPPSIFMQLPQLNRLTLF 283
Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA- 382
N ++ + + +L L L N + + +L L +L LS N + + GA
Sbjct: 284 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 343
Query: 383 RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGI 442
L LR L L NAL+DL F LA+LQ ++LQ NR+ G F+ +
Sbjct: 344 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN---------IFANV 394
Query: 443 TSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNP 477
L ++ L +N++E L G F H L EL L NP
Sbjct: 395 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 430
Score = 90.9 bits (224), Expect = 3e-18
Identities = 127/416 (30%), Positives = 173/416 (41%), Gaps = 62/416 (14%)
Query: 145 LGEAPSLH-----TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRL 199
L E+P L+ L + +N L+R+T FR++ +L L L +N L + G F+GL L
Sbjct: 74 LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 133
Query: 200 THLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQ----LTWLDLRE 252
L LS N L I Q L+ L L N +E P F LT L+L +
Sbjct: 134 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-----PDGAFDHLVGLTKLNLGK 188
Query: 253 NKLLHFPDLAALPRLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG 311
N L H PR ++ +L N ++RL D P G G
Sbjct: 189 NSLTHIS-----PR-VFQHLGNLQVLRLYENRLTD-----------------IPMGTFDG 225
Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
L L L L N+I L+ + +L L LS N + LP L L L
Sbjct: 226 --LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 283
Query: 372 HNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
N+L+ L LG + +LR L L N + LP F+NL LQ L L N++S
Sbjct: 284 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFIS---- 339
Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELDLSSNPGLEVATGALGGL 489
PG AF+G+T LR LSL N ++ L F + L + L +N L G +
Sbjct: 340 PG-----AFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFAN 393
Query: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
L + LQ N L +LP I L E RL P W ++L LRN
Sbjct: 394 VNGLMAIQLQNNQL----ENLPLGIFDHLGKLCELRLYDNP-W--RCDSDILPLRN 442
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/267 (32%), Positives = 120/267 (44%), Gaps = 16/267 (5%)
Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
R L L L L+ N+++++P + L SL L LS N L + L L L
Sbjct: 104 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 163
Query: 372 HNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
N LE + GA L L L L N+L + P F +L +LQ L L NR++
Sbjct: 164 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI----- 218
Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGL 489
P G F G+ +L+ L+L N+I LL G F + L L LS+N ++ L
Sbjct: 219 --PMG--TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 274
Query: 490 EASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNN 546
L L L GN L L + + L+ L L +N +S LP ++ L+VL L N
Sbjct: 275 -PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 333
Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPL 573
S + A GL T LR L L N L
Sbjct: 334 QISFISPGAFNGL-TELRELSLHTNAL 359
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
+L + + +L F N+++L L ++ N +S PG AF + SLR LS
Sbjct: 63 SLQILNTHITELNESPFLNISALIALRIEKNELSRI----TPG-----AFRNLGSLRYLS 113
Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL-MVLQ 507
L +N++++L G F L L LSSN L++ ++L+ L L GN L +
Sbjct: 114 LANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC-SNLKELQLHGNHLEYIPD 172
Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
+ L +LNL +N L+H+ + +L+VL L N + +P GL +L+
Sbjct: 173 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGL-VNLQE 231
Query: 566 LYLQGNPLSCCGNG 579
L LQ N + G
Sbjct: 232 LALQQNQIGLLSPG 245
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 121 bits (303), Expect = 2e-27
Identities = 136/456 (29%), Positives = 192/456 (42%), Gaps = 77/456 (16%)
Query: 32 KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
+V C ++ VP+ LP + +L + + + SP +AL L + NE+S + PG
Sbjct: 36 QVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPG 95
Query: 92 AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSL 151
AF+ L L +LSLA+N+L + L+ GL SL
Sbjct: 96 AFRNLGSLRYLSLANNKLQVLPI--------------------GLFQGL--------DSL 127
Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
+L L+ N L ++ F L++L LH N L I DGAF+ L LT LNL +NSLT
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH 187
Query: 212 ISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP--DLAALPRLIY 269
IS Q L L + L L EN+L P L L
Sbjct: 188 ISPRVFQHLGNLQV----------------------LRLYENRLTDIPMGTFDGLVNLQE 225
Query: 270 LNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRP------LSQLLNLDLS 323
L L N I L S G+ + L LS + + S P L QL L L
Sbjct: 226 LALQQNQIGLL------SPGLFHNNHNLQRLYLS--NNHISQLPPSIFMQLPQLNRLTLF 277
Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA- 382
N ++ + + +L L L N + + +L L +L LS N + + GA
Sbjct: 278 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAF 337
Query: 383 RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGI 442
L LR L L NAL+DL F LA+LQ ++LQ NR+ G F+ +
Sbjct: 338 NGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGN---------IFANV 388
Query: 443 TSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNP 477
L ++ L +N++E L G F H L EL L NP
Sbjct: 389 NGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNP 424
Score = 90.9 bits (224), Expect = 3e-18
Identities = 127/416 (30%), Positives = 173/416 (41%), Gaps = 62/416 (14%)
Query: 145 LGEAPSLH-----TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRL 199
L E+P L+ L + +N L+R+T FR++ +L L L +N L + G F+GL L
Sbjct: 68 LNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSL 127
Query: 200 THLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQ----LTWLDLRE 252
L LS N L I Q L+ L L N +E P F LT L+L +
Sbjct: 128 ESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYI-----PDGAFDHLVGLTKLNLGK 182
Query: 253 NKLLHFPDLAALPRLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG 311
N L H PR ++ +L N ++RL D P G G
Sbjct: 183 NSLTHIS-----PR-VFQHLGNLQVLRLYENRLTD-----------------IPMGTFDG 219
Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
L L L L N+I L+ + +L L LS N + LP L L L
Sbjct: 220 --LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLF 277
Query: 372 HNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
N+L+ L LG + +LR L L N + LP F+NL LQ L L N++S
Sbjct: 278 GNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFIS---- 333
Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELDLSSNPGLEVATGALGGL 489
PG AF+G+T LR LSL N ++ L F + L + L +N L G +
Sbjct: 334 PG-----AFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNN-RLRQLPGNIFAN 387
Query: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
L + LQ N L +LP I L E RL P W ++L LRN
Sbjct: 388 VNGLMAIQLQNNQL----ENLPLGIFDHLGKLCELRLYDNP-W--RCDSDILPLRN 436
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/267 (32%), Positives = 120/267 (44%), Gaps = 16/267 (5%)
Query: 312 RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLS 371
R L L L L+ N+++++P + L SL L LS N L + L L L
Sbjct: 98 RNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLH 157
Query: 372 HNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDE 430
N LE + GA L L L L N+L + P F +L +LQ L L NR++
Sbjct: 158 GNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDI----- 212
Query: 431 PGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGL 489
P G F G+ +L+ L+L N+I LL G F + L L LS+N ++ L
Sbjct: 213 --PMG--TFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQL 268
Query: 490 EASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNN 546
L L L GN L L + + L+ L L +N +S LP ++ L+VL L N
Sbjct: 269 -PQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRN 327
Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPL 573
S + A GL T LR L L N L
Sbjct: 328 QISFISPGAFNGL-TELRELSLHTNAL 353
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
+L + + +L F N+++L L ++ N +S PG AF + SLR LS
Sbjct: 57 SLQILNTHITELNESPFLNISALIALRIEKNELSRI----TPG-----AFRNLGSLRYLS 107
Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGL-MVLQ 507
L +N++++L G F L L LSSN L++ ++L+ L L GN L +
Sbjct: 108 LANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQC-SNLKELQLHGNHLEYIPD 166
Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
+ L +LNL +N L+H+ + +L+VL L N + +P GL +L+
Sbjct: 167 GAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGL-VNLQE 225
Query: 566 LYLQGNPLSCCGNG 579
L LQ N + G
Sbjct: 226 LALQQNQIGLLSPG 239
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 119 bits (297), Expect = 1e-26
Identities = 128/408 (31%), Positives = 181/408 (44%), Gaps = 47/408 (11%)
Query: 79 DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYS 138
DLS N ++ LQPG F L LE L L+ N L+ + GL L L L N L
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSL---KILMLQNNQL-G 75
Query: 139 GLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPR 198
G+ L E PSL +L L N ++ + +F + +L L L N L +I A LP
Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
Query: 199 LTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
L + L+ N ++ I D++ Q L VL L N I+ T S + L LDL NKL
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSF-EGLHNLETLDLNYNKL 194
Query: 256 LHFP-DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP--------- 305
FP + L RL L NN I+ P + + PL
Sbjct: 195 QEFPVAIRTLGRLQELGFHNNNIKA------------IPEKAFMGNPLLQTIHFYDNPIQ 242
Query: 306 -SGNASGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLP 363
G ++ + L +L L L+ +I+ PD L+ TSL L L+R +R + LP
Sbjct: 243 FVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLP 300
Query: 364 CLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
L +L+LSHN +E L L + LQ N + ++ TF+ L+SLQ L+L N +
Sbjct: 301 RLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
Query: 424 PCGGPDEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
P+ AFS + SL L L DN+ + L G +H L
Sbjct: 360 SI-HPE--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 398
Score = 84.0 bits (206), Expect = 4e-16
Identities = 118/419 (28%), Positives = 171/419 (40%), Gaps = 63/419 (15%)
Query: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQ 238
DL N L +++ G F L L L LS N L+ I + L
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------------ 61
Query: 239 PQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
+ L L L+ N+L P A LP L L L NLI L P + +G+ +
Sbjct: 62 ----YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGLSSLRHL 115
Query: 297 W------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
W + +P+ A + L L + L+ N I IPD ++LTSL L+L N
Sbjct: 116 WLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
Query: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLA 410
++ L L LDL++N L+ + R LG L+ L N ++ +P F
Sbjct: 170 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP 229
Query: 411 SLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSLVDNEIE 456
LQ ++ N + G G F G TSL L+L I
Sbjct: 230 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR 289
Query: 457 LLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFI 514
LL +G P L L+LS N E+ +L + LE + LQ N + + D
Sbjct: 290 LLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGADTFSQLS 346
Query: 515 CLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
L+ L+L+ N R H A++ SL LDL +N + LP + +GG L L L+GN
Sbjct: 347 SLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHLKLKGN 401
Score = 68.9 bits (167), Expect = 1e-11
Identities = 91/351 (25%), Positives = 138/351 (39%), Gaps = 38/351 (10%)
Query: 49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
P ++L L N + + ++LRHL L N ++ + A L L+ ++LA NR
Sbjct: 86 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 145
Query: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHT 168
++ + L L L L N + L +L TL L N L
Sbjct: 146 ISHIPDYAFQNLTSL---VVLHLHNNRI-QHLGTHSFEGLHNLETLDLNYNKLQEFP-VA 200
Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQL-RVLDLSC 227
R + L++L H+N + I + AF G P L ++ N + + + Q L ++ LS
Sbjct: 201 IRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL 260
Query: 228 NSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRLIYLNLSNNLIRLPTGPPQ 285
N Q + L L L + P LPRL L LS+N I +
Sbjct: 261 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-------E 313
Query: 286 DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLN 345
+ +H +L + L +N I I L+SL L+
Sbjct: 314 ELPSLHR---------------------CQKLEEIGLQHNRIWEIGADTFSQLSSLQALD 352
Query: 346 LSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGN 396
LS N +R+ +L L+ LDL+ N L TL L LG L L L+GN
Sbjct: 353 LSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA--GLGGLMHLKLKGN 401
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 118 bits (295), Expect = 2e-26
Identities = 125/427 (29%), Positives = 179/427 (41%), Gaps = 26/427 (6%)
Query: 9 LALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASP 68
L L L A C V C L L VP +P +TE LDL+GN + I +
Sbjct: 15 LVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTD 74
Query: 69 LGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTS 128
LR L L N+IS ++ GAFQ L LE L L N L + L G L R
Sbjct: 75 FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYR--- 131
Query: 129 LDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDI 188
LDLS N + + + A + L L N ++ + FR + LE L L++N + +
Sbjct: 132 LDLSENQI-QAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRL 190
Query: 189 EDGAFEGLPRLTHLNLSRNSLTC------ISDFSLQQLRV-LDLSC---NSIEAFQTASQ 238
+F +P+L L N+L C +SD+ Q+ RV L C + + A
Sbjct: 191 SVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEV 250
Query: 239 PQAEFQLTW---LDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
+ EF + +LH P I L +PT P+ I
Sbjct: 251 QKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQN 310
Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEI-ELIPDSFLEHLTSLCFLNLSRNCLRTF 354
+P A S P +L +DLS N+I EL PD+F + L SL L L N +
Sbjct: 311 TIKVIPPGAFS------PYKKLRRIDLSNNQISELAPDAF-QGLRSLNSLVLYGNKITEL 363
Query: 355 EARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQ 413
L L LL L+ N + L + A + L +L L L N L+ + TF+ L ++Q
Sbjct: 364 PKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQ 423
Query: 414 RLNLQGN 420
++L N
Sbjct: 424 TMHLAQN 430
Score = 94.7 bits (234), Expect = 2e-19
Identities = 149/608 (24%), Positives = 234/608 (38%), Gaps = 95/608 (15%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C + V C+ GL ++P+ LP + L N ++ I Y LR +DLS N+I
Sbjct: 277 CTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQI 336
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
S L P AFQ L L L L N++ LP+ SL+ GL
Sbjct: 337 SELAPDAFQGLRSLNSLVLYGNKIT-----------ELPK---------SLFEGLF---- 372
Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
SL L L N + L F+D+ L L L+ N L I G F L + ++L+
Sbjct: 373 ----SLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLA 428
Query: 206 RNSLTC------ISDF------------SLQQLRVLDLSCNSIEAFQTASQPQAEFQLTW 247
+N C ++D+ R+ + I++ + + ++ +
Sbjct: 429 QNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPG 488
Query: 248 LDLRENKLLH--FPDLAALPRL----IYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSAL 300
+ +KL F DLA + ++ SN L ++P PQ + + + ++ L
Sbjct: 489 TEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVL 548
Query: 301 PLSAPSGNASG--RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARR 358
A+G + L QL ++ S N+I I + E + + + L+ N L + +
Sbjct: 549 -------EATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKM 601
Query: 359 LGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNL 417
L L L L N + + + L S+R L L N + + P F L SL LNL
Sbjct: 602 FKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNL 661
Query: 418 QGNRVS-----------------PCGGPD-------EPGPSGCVAFSGITSLRSLSLVDN 453
N + G P + P VA T DN
Sbjct: 662 LANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGND--DN 719
Query: 454 EIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCF 513
L T L + SN GL+V G+ + L L GN ++ +L +
Sbjct: 720 SCSPLSRCPTECTCLDTVVRCSNKGLKVLP---KGIPRDVTELYLDGNQFTLVPKELSNY 776
Query: 514 ICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
L ++L+ NR+S L +++ L L L N +P GL+ SLR L L GN
Sbjct: 777 KHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLK-SLRLLSLHGN 835
Query: 572 PLSCCGNG 579
+S G
Sbjct: 836 DISVVPEG 843
Score = 72.0 bits (175), Expect = 2e-12
Identities = 103/428 (24%), Positives = 173/428 (40%), Gaps = 65/428 (15%)
Query: 32 KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQP- 90
K+S L P + T+D S +L I + YTA L L+ NE + L+
Sbjct: 495 KLSGDCFADLACPEKCRCEGTTVDCSNQKLNKI-PEHIPQYTA--ELRLNNNEFTVLEAT 551
Query: 91 GAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPS 150
G F+ L L ++ ++N++ T + G V + L+ N L + ++ S
Sbjct: 552 GIFKKLPQLRKINFSNNKI---TDIEEGAFEGASGVNEILLTSNRL-ENVQHKMFKGLES 607
Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN--S 208
L TL L N +T + +F + ++ L L+ N + + GAF+ L L+ LNL N +
Sbjct: 608 LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN 667
Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
C + + LR + + Q + L + +++ + F
Sbjct: 668 CNCYLAWLGEWLRKKRIVTGNPRC-------QKPYFLKEIPIQDVAIQDFTCDDGNDD-- 718
Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
N + L R PT + ++G LP P + L L N+
Sbjct: 719 --NSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPR---------DVTELYLDGNQFT 767
Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGS 387
L+P + L + L L+DLS+N + TL + + +
Sbjct: 768 LVP-------------------------KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQ 802
Query: 388 LRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRS 447
L TL+L N LR +PP TF L SL+ L+L GN +S P G AF+ +++L
Sbjct: 803 LLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV-------PEG--AFNDLSALSH 853
Query: 448 LSLVDNEI 455
L++ N +
Sbjct: 854 LAIGANPL 861
Score = 55.5 bits (132), Expect = 2e-07
Identities = 45/136 (33%), Positives = 63/136 (46%), Gaps = 5/136 (3%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C +D V C GL +P +P D L L GNQ +++ L Y L +DLS N I
Sbjct: 731 CTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQF-TLVPKELSNYKHLTLIDLSNNRI 789
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
S L +F +T L L L++NRL + GL L L L GN + S + E
Sbjct: 790 STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSL---RLLSLHGNDI-SVVPEGAF 845
Query: 146 GEAPSLHTLSLAENSL 161
+ +L L++ N L
Sbjct: 846 NDLSALSHLAIGANPL 861
Score = 47.4 bits (111), Expect = 4e-05
Identities = 60/203 (29%), Positives = 90/203 (44%), Gaps = 19/203 (9%)
Query: 390 TLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLS 449
T+ G ALR +P N +RL+L GN ++ D F+G+ LR L
Sbjct: 38 TVDCHGLALRSVPRNIPRNT---ERLDLNGNNITRITKTD---------FAGLRHLRVLQ 85
Query: 450 LVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL-Q 507
L++N+I + GAF L L L+ N L++ L A L L L N + + +
Sbjct: 86 LMENKISTIERGAFQDLKELERLRLNRN-HLQLFPELLFLGTAKLYRLDLSENQIQAIPR 144
Query: 508 VDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRR 565
+ +K L L N++S + A+ LEVL L NN+ + L ++ + LR
Sbjct: 145 KAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM-PKLRT 203
Query: 566 LYLQGNPLSC-CGNGWLAAQLHQ 587
L N L C C WL+ L Q
Sbjct: 204 FRLHSNNLYCDCHLAWLSDWLRQ 226
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 115 bits (289), Expect = 1e-25
Identities = 134/458 (29%), Positives = 196/458 (42%), Gaps = 90/458 (19%)
Query: 2 RPQILLLLALLTLGL---AAQHQDKVPCKMV----DKKVSCQVLGLLQVPSVLPPDTETL 54
R LLLL LL L L A + PC + C GL +P LP T +L
Sbjct: 14 RSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSL 73
Query: 55 DLSGNQLRSILASPLGFYTA--LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
+LS N+L I P GF L+ + L+ NE++ + P A +H+ L L HN++
Sbjct: 74 NLSYNKLSEI--DPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSV 130
Query: 113 TA-------------LSAGGLGPL--------PRVTSLDLSGNSLYSGLLERLLGEAPSL 151
LS + + P + L+L+GN + + L G + SL
Sbjct: 131 EGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSL 190
Query: 152 HTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
TL L++N +T+L F+ +P L QLDL+ N + IE F+GL L L L RN+++
Sbjct: 191 LTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK 249
Query: 212 ISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
++D + L ++ VL L NS+ + S L L L
Sbjct: 250 LTDGAFWGLSKMHVLHLEYNSLVEVNSGS-----------------------LYGLTALH 286
Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
L+LSNN I IH +GWS +L L LS+N +
Sbjct: 287 QLHLSNNSIAR----------IHR--KGWSFC--------------QKLHELVLSFNNLT 320
Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALE-TLELGARA--- 384
+ + L L+SL L LS N + L L +LDL HN + T+E + A
Sbjct: 321 RLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSG 380
Query: 385 LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
L SL L L GN ++ + F+ L L+ LNL GN +
Sbjct: 381 LDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAI 418
Score = 55.1 bits (131), Expect = 2e-07
Identities = 82/311 (26%), Positives = 127/311 (40%), Gaps = 45/311 (14%)
Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPP 403
LNLS N L + LP L + L++N L + A + +L LQ N +R +
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEG 132
Query: 404 YTFANLASLQRLNLQGNRVS-------PCGGP--------DEPGPSGCVAFSGIT-SLRS 447
SL+ L+L N ++ P G P + G AF G++ SL +
Sbjct: 133 SQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLT 192
Query: 448 LSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQ 507
L L N I L AF LT+LDL+ N + GL SLEVL LQ N +
Sbjct: 193 LRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLN-SLEVLKLQRNNI---- 247
Query: 508 VDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLY 567
++L+ W + + VL L NS + ++ GL T+L +L+
Sbjct: 248 ----------------SKLTDGAFWGLS-KMHVLHLEYNSLVEVNSGSLYGL-TALHQLH 289
Query: 568 LQGNPLS-CCGNGWLAAQ-LHQGRVDVD----ATQDLICRFSSQEEVSLSHVRPEDCEKG 621
L N ++ GW Q LH+ + + ++ + SS + LSH +G
Sbjct: 290 LSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEG 349
Query: 622 GLKNINLIIIL 632
K + + +L
Sbjct: 350 AFKGLRSLRVL 360
Score = 30.0 bits (66), Expect = 7.1
Identities = 16/52 (30%), Positives = 27/52 (51%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLA 105
L L GN+++S+ L HL+L N I +Q AF + +L+ L ++
Sbjct: 387 LTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHIS 438
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 115 bits (288), Expect = 1e-25
Identities = 127/404 (31%), Positives = 171/404 (42%), Gaps = 71/404 (17%)
Query: 6 LLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSIL 65
LL L LL G C + V C L VP LP DTE LDLSGN+L +
Sbjct: 17 LLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQ 76
Query: 66 ASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR 125
L + L+ LDLS N++S L+PGAF L L L L NRL
Sbjct: 77 QGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLR--------------- 121
Query: 126 VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVL 185
+ G ++SGL +L L L N + F ++ +L++L++ N L
Sbjct: 122 -----IMGPGVFSGL--------SALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL 168
Query: 186 MDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ--------QLRVLDLSCNSIEAFQTAS 237
+ + GAF GL +L+ L L R +L+ + +L +LR LD+ A +
Sbjct: 169 VFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLG 228
Query: 238 QPQAEFQLTWLDLRENKLLHFPDLAALP--RLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
Q L+E ++ +P L AL L+ LNLS+ I
Sbjct: 229 Q-----------LKELEIHLWPSLEALDPGSLVGLNLSSLAI---------------TRC 262
Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFE 355
S++P A LS L LDLS N I IP L L L L LS CL +
Sbjct: 263 NLSSVPFQAL------YHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIA 316
Query: 356 ARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
A L LLD++ NAL+TLE A + L TL L GN L
Sbjct: 317 AHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Score = 68.6 bits (166), Expect = 2e-11
Identities = 106/365 (29%), Positives = 139/365 (38%), Gaps = 69/365 (18%)
Query: 121 GPLPRVTSL-DLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD 179
G LP T L DLSGN L+ GL + +L L L L+ N L+ L F + +L L
Sbjct: 56 GGLPLDTELLDLSGNRLW-GLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLR 114
Query: 180 LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTA 236
L N L + G F GL LT L+L N + D + L L+ L++ N + F
Sbjct: 115 LQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHL-VFVAP 173
Query: 237 SQPQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSN-NLIRLPTGPPQDSKGIHAP 293
+L+ L L L P LA LP L+ L L ++ RLP G
Sbjct: 174 GAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAG----------- 222
Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
+ R L QL L EI L P SL LNLS +
Sbjct: 223 ----------------ALRGLGQLKEL-----EIHLWPSLEALDPGSLVGLNLSSLAITR 261
Query: 354 FEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQ 413
L S+P L LS LR L L N + +P + L LQ
Sbjct: 262 CN---LSSVPFQALYHLSF---------------LRVLDLSQNPISAIPARRLSPLVRLQ 303
Query: 414 RLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPLTELD 472
L L G ++ AF G+T+ L + DN ++ L AF L L
Sbjct: 304 ELRLSGACLTSIAAH---------AFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLR 354
Query: 473 LSSNP 477
LS NP
Sbjct: 355 LSGNP 359
Score = 36.2 bits (82), Expect = 0.099
Identities = 35/93 (37%), Positives = 40/93 (43%), Gaps = 22/93 (23%)
Query: 487 GGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNN 546
GGL E+L L GN L LQ + L RL+L L+ LDL N
Sbjct: 56 GGLPLDTELLDLSGNRLWGLQQGM-----LSRLSL----------------LQELDLSYN 94
Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNG 579
S L A GL+ SL L LQGN L G G
Sbjct: 95 QLSTLEPGAFHGLQ-SLLTLRLQGNRLRIMGPG 126
Score = 35.8 bits (81), Expect = 0.13
Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 8/97 (8%)
Query: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLS 527
L ELDLS N + GA GL+ SL L LQGN L ++ + F L L L + RL+
Sbjct: 86 LQELDLSYNQLSTLEPGAFHGLQ-SLLTLRLQGNRLRIMGPGV--FSGLSALTLLDLRLN 142
Query: 528 HL-----PAWTQAVSLEVLDLRNNSFSLLPGSAMGGL 559
+ A+ + SL+ L++ +N + A GL
Sbjct: 143 QIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGL 179
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 114 bits (284), Expect = 4e-25
Identities = 121/408 (29%), Positives = 184/408 (45%), Gaps = 37/408 (9%)
Query: 32 KVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPG 91
+V C LGL ++PS L T LDLS N + +L +PL L L L+ N ++++ G
Sbjct: 49 RVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKG 108
Query: 92 AFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGN-------SLYSGLLERL 144
AF L L+ L L +N+L + L L + SL L N S +SGL
Sbjct: 109 AFTGLYSLKVLMLQNNQL---RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL---- 161
Query: 145 LGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNL 204
SL L L +N+LT + FR + AL+ + L N + I D AF L L L+L
Sbjct: 162 ----HSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHL 217
Query: 205 SRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDL 261
N + + L L LDL+ N+++ F TA + + L L N + P+
Sbjct: 218 HNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLS--NLKELGFHSNNIRSIPEK 275
Query: 262 AAL--PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLN 319
A + P LI ++ +N I+ S H P L L+ S L+ N
Sbjct: 276 AFVGNPSLITIHFYDNPIQF----VGRSAFQHLPE--LRTLTLNGASQITEFPDLTGTAN 329
Query: 320 LD---LSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALE 376
L+ L+ +I +P + L +L L+LS N L + L +DL HN +
Sbjct: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIY 387
Query: 377 TLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
+++ + L SLR+L L N + + P F+ L SL +L+L N +S
Sbjct: 388 EIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
Score = 82.8 bits (203), Expect = 9e-16
Identities = 112/406 (27%), Positives = 171/406 (42%), Gaps = 55/406 (13%)
Query: 200 THLNLSRNSLTCISDFSLQQLRVLD---LSCNSIEAFQTASQPQAEFQLTWLDLRENKLL 256
++L+LS N+++ + L LR L+ L+ N++ + + L L L+ N+L
Sbjct: 69 SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGL-YSLKVLMLQNNQLR 127
Query: 257 HFPD--LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW------SALPLSAPSGN 308
H P L L L L L N I PP G+H+ W + +P+ A
Sbjct: 128 HVPTEALQNLRSLQSLRLDANHISYV--PPSCFSGLHSLRHLWLDDNALTEIPVQA---- 181
Query: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
R LS L + L+ N+I IPD +L+SL L+L N + + + L L L
Sbjct: 182 --FRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETL 239
Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
DL++N L+ R L +L+ L N +R +P F SL ++ N + G
Sbjct: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRS 299
Query: 429 -----------DEPGPSGCVAF---SGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDL 473
G S F +G +L SL+L +I L P L LDL
Sbjct: 300 AFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDL 359
Query: 474 SSN-----PGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLS 527
S N P V L+ + L+ N + ++VD + L+ LNLA N+++
Sbjct: 360 SYNLLEDLPSFSVC--------QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIA 411
Query: 528 --HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
H A++ SL LDL +N S P + + G L L L GN
Sbjct: 412 IIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHG----LTHLKLTGN 453
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/179 (27%), Positives = 84/179 (46%), Gaps = 12/179 (6%)
Query: 49 PDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNR 108
P+ TL L+G + G L L L+ +IS L L +L+ L L++N
Sbjct: 305 PELRTLTLNGASQITEFPDLTGTAN-LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNL 363
Query: 109 LAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHT 168
L + S ++ +DL N +Y ++ + SL +L+LA N + + +
Sbjct: 364 LEDLPSFSV-----CQKLQKIDLRHNEIYEIKVDTFQ-QLLSLRSLNLAWNKIAIIHPNA 417
Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL--TCISDFSLQQLRVLDL 225
F +P+L +LDL SN+L GL LTHL L+ N + IS + +L+V+++
Sbjct: 418 FSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 113 bits (283), Expect = 5e-25
Identities = 145/514 (28%), Positives = 203/514 (39%), Gaps = 85/514 (16%)
Query: 3 PQILLLLALLTLGL--------AAQHQDKVPCKMV-DKKVSCQVLGLLQVPSVLPPDTET 53
P L LL L LGL AA PC D++V C GL VP L T+
Sbjct: 2 PGPLGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQA 61
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
LD+S N + + + L L L+ N++SF+ P A L L+ L+L +N+L
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
+ + GL L SL L N + S + G H L L +NSLT + H ++P
Sbjct: 122 SEAIRGLSAL---QSLRLDANHITSVPEDSFEGLVQLRH-LWLDDNSLTEVPVHPLSNLP 177
Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDF---SLQQLRVLDLSCNSI 230
L+ L L N + I D AF L L L+L N + +S L L LDL+ N++
Sbjct: 178 TLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNL 237
Query: 231 EAFQTASQPQAEFQLTWLDLRENKLLHFPDLA----ALPRLIYL--------------NL 272
F A +A L L N + PD A L R I+L NL
Sbjct: 238 GEFPQAI--KALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Query: 273 SNNLIRLPTGP------PQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNE 326
S+ + G P + +H S + +S+ N + L LDLSYN
Sbjct: 296 SDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLC-QEQKMLRTLDLSYNN 354
Query: 327 IELIP----------------------DSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPC 364
I +P + + L SL L+LSRN + +R +L
Sbjct: 355 IRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGP 414
Query: 365 LMLLDLSHNALETLELGARALGSLRTLLLQGN-ALRD-LPPYTFANLASLQRLNLQGNRV 422
+ LD+S N L + L L L L GN L++ L F NL SL
Sbjct: 415 ITNLDVSFNELTSFP--TEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSL---------- 462
Query: 423 SPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIE 456
P C AF G S +L+ DN ++
Sbjct: 463 ------SVPYAYQCCAFWGCDSYANLNTEDNSLQ 490
Score = 74.7 bits (182), Expect = 3e-13
Identities = 95/357 (26%), Positives = 141/357 (39%), Gaps = 44/357 (12%)
Query: 202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL--LHFP 259
++ S LT + + + LD+S N+I + F L L L N L +H
Sbjct: 41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPF-LEELQLAGNDLSFIHPK 99
Query: 260 DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLN 319
L+ L L L L NN +L T P + +G LS L +
Sbjct: 100 ALSGLKELKVLTLQNN--QLKTVPSEAIRG------------------------LSALQS 133
Query: 320 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL- 378
L L N I +P+ E L L L L N L L +LP L L L+ N + ++
Sbjct: 134 LRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIP 193
Query: 379 ELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVA 438
+ L SL L L N +R L + F L +L+ L+L N + A
Sbjct: 194 DFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQ----------A 243
Query: 439 FSGITSLRSLSLVDNEIELLRAGAFLHTPLTE-LDLSSNPGLEVATGALGGLEASLEVLA 497
+ SL+ L N I ++ GAF PL + L NP V A L + L L
Sbjct: 244 IKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL-SDLHSLV 302
Query: 498 LQGNGLMVLQVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLP 552
++G ++ +L + L+ L L ++S +P + L LDL N+ LP
Sbjct: 303 IRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLP 359
Score = 72.8 bits (177), Expect = 1e-12
Identities = 75/264 (28%), Positives = 116/264 (43%), Gaps = 41/264 (15%)
Query: 320 LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLE 379
LD+S N I +P+ ++ L L L+ N L + L L L +L L +N L+T+
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 380 LGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVA 438
A R L +L++L L N + +P +F L L+ L L N ++ P P
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEV--PVHP------- 172
Query: 439 FSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLAL 498
S + +L++L+L N+I + AF + +SL VL L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNL------------------------SSLVVLHL 208
Query: 499 QGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAV----SLEVLDLRNNSFSLLPGS 554
N + L CF L L + ++L + QA+ SL+ L +NS S++P
Sbjct: 209 HNNKIRSLSQH--CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDG 266
Query: 555 AMGGLETSLRRLYLQGNPLSCCGN 578
A G LR ++L NPLS GN
Sbjct: 267 AFDG-NPLLRTIHLYDNPLSFVGN 289
Score = 49.7 bits (117), Expect = 9e-06
Identities = 63/210 (30%), Positives = 90/210 (42%), Gaps = 17/210 (8%)
Query: 368 LDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGG 427
+D S L + G A + L + N + LP F N L+ L L GN +S
Sbjct: 41 VDCSGKGLTAVPEGLSAF--TQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHP 98
Query: 428 PDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGAL 486
A SG+ L+ L+L +N+++ + + A + L L L +N V +
Sbjct: 99 K---------ALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSF 149
Query: 487 GGLEASLEVLALQGNGLMVLQVD-LPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDL 543
GL L L L N L + V L L+ L LA N++S +P A+T SL VL L
Sbjct: 150 EGL-VQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHL 208
Query: 544 RNNSFSLLPGSAMGGLETSLRRLYLQGNPL 573
NN L GL+ +L L L N L
Sbjct: 209 HNNKIRSLSQHCFDGLD-NLETLDLNYNNL 237
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 112 bits (281), Expect = 8e-25
Identities = 160/557 (28%), Positives = 224/557 (40%), Gaps = 92/557 (16%)
Query: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISF--LQP 90
V C + L + P LP T L L NQL I L L L+L N ++ L
Sbjct: 128 VDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPE 187
Query: 91 GAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPS 150
AF+ LT+L +L LA+N+L +A LP +
Sbjct: 188 KAFEHLTNLNYLYLANNKLTLAPRF-------LPN------------------------A 216
Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMD--IEDGAFEGLPRLTHLNLSRNS 208
L ++ A N LT++ TF P L + LH+N L D + D F G + L LS N
Sbjct: 217 LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNF 276
Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL----LHFPDLAAL 264
L + L L L N +E + + L L L+ N L L L
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELS-SLRELYLQNNYLTDEGLDNETFWKL 335
Query: 265 PRLIYLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLS 323
L YL+LS NNL R+P G P+ L+ L L
Sbjct: 336 SSLEYLDLSSNNLSRVPAGLPRS------------------------------LVLLHLE 365
Query: 324 YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG--SLPCLMLLDLSHNALETLELG 381
N I + + L + SL +L L N LR L L L + L +NALE + G
Sbjct: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425
Query: 382 ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV-SPCGGPDEPGPSGCVAFS 440
+RTL++ N + + FA L+ LNL NR+ SP D AF
Sbjct: 426 LPR--RVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRD--------AFR 475
Query: 441 GITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQG 500
+ LRSL L N + L G L + L + N +A GAL G+ A L L L
Sbjct: 476 KLRLLRSLDLSGNRLHTLPPG--LPRNVHVLKVKRNELAALARGALVGM-AQLRELYLTS 532
Query: 501 NGLMVLQVDLPCFICLKRLNL---AENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMG 557
N L + ++ L L L A N+L+ +P SLE L L+NN S +P +A
Sbjct: 533 NRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE-SLEYLYLQNNKISAVPANAFD 591
Query: 558 GLETSLRRLYLQGNPLS 574
+L+ ++L+ N L+
Sbjct: 592 S-TPNLKGIFLRFNKLA 607
Score = 50.4 bits (119), Expect = 5e-06
Identities = 64/216 (29%), Positives = 89/216 (41%), Gaps = 31/216 (14%)
Query: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQP--GAFQALT 97
L +VPS LP TL + NQ+ I L L+LS N I+ Q AF+ L
Sbjct: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478
Query: 98 HLEHLSLAHNRLAMA------------------TALSAGGLGPLPRVTSLDLSGNSLYSG 139
L L L+ NRL AL+ G L + ++ L L+ N L S
Sbjct: 479 LLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSR 538
Query: 140 LL-ERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP-ALEQLDLHSNVLMDIEDGAFEGLP 197
L R + L L +A N LT + +P +LE L L +N + + AF+ P
Sbjct: 539 ALGPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTP 594
Query: 198 RLTHLNLSRNSLTCISDFS-----LQQLRVLDLSCN 228
L + L N L S L+ L+VLD+ N
Sbjct: 595 NLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 112 bits (280), Expect = 1e-24
Identities = 114/403 (28%), Positives = 174/403 (43%), Gaps = 61/403 (15%)
Query: 2 RPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
+P +LL+L + G A + C D+ V C + VP +P +T LDL N++
Sbjct: 24 QPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRI 83
Query: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
+++ + L L+L+ N +S ++PGAF L +L L L NRL + + G
Sbjct: 84 KTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKL---IPLGVFT 140
Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
L +T LD+S N + LL+ + + +L +L + +N L ++ F + +LEQL L
Sbjct: 141 GLSNLTKLDISENKIVI-LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLE 199
Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTASQ 238
L I A L L L L ++ I D+S L +L+VL++S
Sbjct: 200 KCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEIS------------ 247
Query: 239 PQAEFQLTWLDLRENKLLHFPDLAAL-PRLIY-LNLSNNLIRLPTGPPQDSKGIHAPSEG 296
H+P L + P +Y LNL++ I H
Sbjct: 248 ------------------HWPYLDTMTPNCLYGLNLTSLSI------------THC---N 274
Query: 297 WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
+A+P A R L L L+LSYN I I S L L L + L L E
Sbjct: 275 LTAVPYLAV------RHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEP 328
Query: 357 RRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
L L +L++S N L TLE ++G+L TL+L N L
Sbjct: 329 YAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
Score = 52.0 bits (123), Expect = 2e-06
Identities = 65/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)
Query: 339 TSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNA 397
T L+L +N ++T S P L L+L+ N + +E GA L +LRTL L+ N
Sbjct: 71 TETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNR 130
Query: 398 LRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
L+ +P F L++L +L++ N++ F + +L+SL + DN++
Sbjct: 131 LKLIPLGVFTGLSNLTKLDISENKIVILLD---------YMFQDLYNLKSLEVGDNDLVY 181
Query: 458 LRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICL 516
+ AF L +L L + T AL L ++ L+ L + + F L
Sbjct: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHG---LIVLRLRHLNINAIRDYSFKRL 238
Query: 517 KRLNLAENRLSH-------LPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQ 569
RL + E +SH P ++L L + + + + +P A+ L LR L L
Sbjct: 239 YRLKVLE--ISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHL-VYLRFLNLS 295
Query: 570 GNPLS 574
NP+S
Sbjct: 296 YNPIS 300
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 112 bits (279), Expect = 1e-24
Identities = 140/451 (31%), Positives = 203/451 (45%), Gaps = 54/451 (11%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C VD V C L L P + + L L NQL+ + + L + LR L+L N I
Sbjct: 50 CPRVDT-VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 108
Query: 86 SF--LQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR-VTSLDLSGNSLYSGLLE 142
S L AF++LT L+HL +AHN+L++A LPR + DL+ N + +
Sbjct: 109 SSEGLPDEAFESLTQLQHLCVAHNKLSVAPQF-------LPRSLRVADLAANQVME-IFP 160
Query: 143 RLLGEAPSLHTLSLAENSLTR--LTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT 200
GE P+L ++ L N L+ L FR A+ L L +N L + P L
Sbjct: 161 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 217
Query: 201 HLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI-EAFQTASQPQAEFQLTWLDLRENKLL 256
L+L N ++ + +L QLR L L N + ++ A+ L +LDL N+L
Sbjct: 218 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 277
Query: 257 HFPDLAALPR-LIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG---- 311
P A LPR L L+L N IR ++ +H + G L L +SG
Sbjct: 278 TVP--AGLPRTLAILHLGRNRIR-----QVEAARLHG-ARGLRYLLLQHNQLGSSGLPAG 329
Query: 312 --RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
RPL L L L N ++ +P + L +L L N + AR L + P L L+
Sbjct: 330 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV---LPHNHVAALGARDLVATPGLTELN 386
Query: 370 LSHNALETLELGARA---LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
L++N L + + RA L +LR+L L GN L LP L +LQ LQ N++
Sbjct: 387 LAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRML- 442
Query: 427 GPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
EP P +G+ LR LSL N + +
Sbjct: 443 ---EPEP-----LAGLDQLRELSLAHNRLRV 465
Score = 102 bits (253), Expect = 1e-21
Identities = 135/438 (30%), Positives = 186/438 (42%), Gaps = 60/438 (13%)
Query: 124 PRVTSLDLSGNSLYSGLLERLLGE--APSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
PRV ++D G L R+ + + LSL N L L + + L L+LH
Sbjct: 51 PRVDTVDCDGLDL------RVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLH 104
Query: 182 SNVLMD--IEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI-EAFQTASQ 238
+N++ + D AFE L +L HL ++ N L+ F + LRV DL+ N + E F
Sbjct: 105 NNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFG 164
Query: 239 PQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNN-LIRLPTGPPQDSKGIHAPSE 295
+ + +L + P A + L+LSNN L LP P + +H +
Sbjct: 165 EKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224
Query: 296 GWSALPLSAPSGNASGRPL----SQLLN----------------LDLSYNEIELIPDSFL 335
S +P A S R L +QL + LDLS+N++ +P
Sbjct: 225 LISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP 284
Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLR---TLL 392
+L L+L RN +R EA RL L L L HN L + L A AL LR TL
Sbjct: 285 R---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH 341
Query: 393 LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD 452
L GN L +PP A L+ L L N V+ G D VA G+T L+L
Sbjct: 342 LYGNGLDRVPP---ALPRRLRALVLPHNHVAALGARD------LVATPGLT---ELNLAY 389
Query: 453 NEIELLRA--GAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
N + R AF L LDL+ N T GL L L LQ N L +L+ +
Sbjct: 390 NRLASARVHHRAFRRLRALRSLDLAGNQ----LTRLPMGLPTGLRTLQLQRNQLRMLEPE 445
Query: 510 -LPCFICLKRLNLAENRL 526
L L+ L+LA NRL
Sbjct: 446 PLAGLDQLRELSLAHNRL 463
Score = 63.9 bits (154), Expect = 4e-10
Identities = 69/234 (29%), Positives = 98/234 (41%), Gaps = 49/234 (20%)
Query: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
L LQ N L++LP + L+ L+ LNL N +S G PDE AF +T L+ L +
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE-------AFESLTQLQHLCV 129
Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
N++ + A FL L DL++N +E+ G A
Sbjct: 130 AHNKLSV--APQFLPRSLRVADLAANQVMEIFPLTFGEKPA------------------- 168
Query: 511 PCFICLKRLNLAENRLSH--LP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
L+ + L N+LS+ LP A+ + ++ L L NN S LP S L SL RL
Sbjct: 169 -----LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPS----LPPSLERL 219
Query: 567 YLQGNPLSCCGNGWLAAQL--------HQGRVDVDATQDLICRFSSQEEVSLSH 612
+LQ N +S G L+ Q H D + S E + LSH
Sbjct: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH 273
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/70 (42%), Positives = 39/70 (55%), Gaps = 9/70 (12%)
Query: 53 TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
+LDL+GNQL + P+G T LR L L N++ L+P L L LSLAHNRL +
Sbjct: 410 SLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV- 465
Query: 113 TALSAGGLGP 122
G +GP
Sbjct: 466 -----GDIGP 470
Score = 35.0 bits (79), Expect = 0.22
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--EISFLQPGAFQALT 97
L ++P LP TL L NQLR + PL LR L L+ N + + PG + L
Sbjct: 418 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 477
Query: 98 HLE--HLSLAH 106
L+ H ++H
Sbjct: 478 ALQVRHRLVSH 488
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 112 bits (279), Expect = 1e-24
Identities = 140/451 (31%), Positives = 203/451 (45%), Gaps = 54/451 (11%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C VD V C L L P + + L L NQL+ + + L + LR L+L N I
Sbjct: 52 CPRVDT-VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 110
Query: 86 SF--LQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPR-VTSLDLSGNSLYSGLLE 142
S L AF++LT L+HL +AHN+L++A LPR + DL+ N + +
Sbjct: 111 SSEGLPDEAFESLTQLQHLCVAHNKLSVAPQF-------LPRSLRVADLAANQVME-IFP 162
Query: 143 RLLGEAPSLHTLSLAENSLTR--LTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLT 200
GE P+L ++ L N L+ L FR A+ L L +N L + P L
Sbjct: 163 LTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---PPSLE 219
Query: 201 HLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI-EAFQTASQPQAEFQLTWLDLRENKLL 256
L+L N ++ + +L QLR L L N + ++ A+ L +LDL N+L
Sbjct: 220 RLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLT 279
Query: 257 HFPDLAALPR-LIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASG---- 311
P A LPR L L+L N IR ++ +H + G L L +SG
Sbjct: 280 TVP--AGLPRTLAILHLGRNRIR-----QVEAARLHG-ARGLRYLLLQHNQLGSSGLPAG 331
Query: 312 --RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
RPL L L L N ++ +P + L +L L N + AR L + P L L+
Sbjct: 332 ALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV---LPHNHVAALGARDLVATPGLTELN 388
Query: 370 LSHNALETLELGARA---LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
L++N L + + RA L +LR+L L GN L LP L +LQ LQ N++
Sbjct: 389 LAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ---LQRNQLRML- 444
Query: 427 GPDEPGPSGCVAFSGITSLRSLSLVDNEIEL 457
EP P +G+ LR LSL N + +
Sbjct: 445 ---EPEP-----LAGLDQLRELSLAHNRLRV 467
Score = 102 bits (253), Expect = 1e-21
Identities = 135/438 (30%), Positives = 186/438 (42%), Gaps = 60/438 (13%)
Query: 124 PRVTSLDLSGNSLYSGLLERLLGE--APSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
PRV ++D G L R+ + + LSL N L L + + L L+LH
Sbjct: 53 PRVDTVDCDGLDL------RVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLH 106
Query: 182 SNVLMD--IEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI-EAFQTASQ 238
+N++ + D AFE L +L HL ++ N L+ F + LRV DL+ N + E F
Sbjct: 107 NNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFG 166
Query: 239 PQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNN-LIRLPTGPPQDSKGIHAPSE 295
+ + +L + P A + L+LSNN L LP P + +H +
Sbjct: 167 EKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 226
Query: 296 GWSALPLSAPSGNASGRPL----SQLLN----------------LDLSYNEIELIPDSFL 335
S +P A S R L +QL + LDLS+N++ +P
Sbjct: 227 LISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLP 286
Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLR---TLL 392
+L L+L RN +R EA RL L L L HN L + L A AL LR TL
Sbjct: 287 R---TLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLH 343
Query: 393 LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD 452
L GN L +PP A L+ L L N V+ G D VA G+T L+L
Sbjct: 344 LYGNGLDRVPP---ALPRRLRALVLPHNHVAALGARD------LVATPGLT---ELNLAY 391
Query: 453 NEIELLRA--GAFLH-TPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
N + R AF L LDL+ N T GL L L LQ N L +L+ +
Sbjct: 392 NRLASARVHHRAFRRLRALRSLDLAGNQ----LTRLPMGLPTGLRTLQLQRNQLRMLEPE 447
Query: 510 -LPCFICLKRLNLAENRL 526
L L+ L+LA NRL
Sbjct: 448 PLAGLDQLRELSLAHNRL 465
Score = 63.9 bits (154), Expect = 4e-10
Identities = 69/234 (29%), Positives = 98/234 (41%), Gaps = 49/234 (20%)
Query: 391 LLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL 450
L LQ N L++LP + L+ L+ LNL N +S G PDE AF +T L+ L +
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDE-------AFESLTQLQHLCV 131
Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
N++ + A FL L DL++N +E+ G A
Sbjct: 132 AHNKLSV--APQFLPRSLRVADLAANQVMEIFPLTFGEKPA------------------- 170
Query: 511 PCFICLKRLNLAENRLSH--LP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
L+ + L N+LS+ LP A+ + ++ L L NN S LP S L SL RL
Sbjct: 171 -----LRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPS----LPPSLERL 221
Query: 567 YLQGNPLSCCGNGWLAAQL--------HQGRVDVDATQDLICRFSSQEEVSLSH 612
+LQ N +S G L+ Q H D + S E + LSH
Sbjct: 222 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSH 275
Score = 51.2 bits (121), Expect = 3e-06
Identities = 30/70 (42%), Positives = 39/70 (55%), Gaps = 9/70 (12%)
Query: 53 TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA 112
+LDL+GNQL + P+G T LR L L N++ L+P L L LSLAHNRL +
Sbjct: 412 SLDLAGNQLTRL---PMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV- 467
Query: 113 TALSAGGLGP 122
G +GP
Sbjct: 468 -----GDIGP 472
Score = 35.0 bits (79), Expect = 0.22
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 4/71 (5%)
Query: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN--EISFLQPGAFQALT 97
L ++P LP TL L NQLR + PL LR L L+ N + + PG + L
Sbjct: 420 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 479
Query: 98 HLE--HLSLAH 106
L+ H ++H
Sbjct: 480 ALQVRHRLVSH 490
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 110 bits (276), Expect = 3e-24
Identities = 191/731 (26%), Positives = 292/731 (39%), Gaps = 143/731 (19%)
Query: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN-------EISFLQPGA 92
L Q+PS LP L L N + +I + L++L L+ N E + ++ G
Sbjct: 137 LPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV 196
Query: 93 FQALTHLEHLSLAHNRLAMATA------------------LSAGGLGPLPRVTSLDLSGN 134
F+ LT+LE LSL+ N L+ +S L +T LDLSGN
Sbjct: 197 FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256
Query: 135 SLY---------------SGLLERLLGE-APSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
S ++R + L L+L+ SL ++ F++MP L+ L
Sbjct: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
Query: 179 DLHSNVLM-DIEDGAF-EGLPRLTHLNLSRN----SLTCISDFSLQQLRVLDLSCNSIEA 232
DL N L+ +I GAF LPRL L+LS N S + S ++L L +
Sbjct: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
Query: 233 FQTASQPQAEFQ-------LTWLDLREN--KLLHFPDLAALPRLIYLNLSNNLIRLPTGP 283
+ + +FQ L+ ++L N K + F L + LS N I +
Sbjct: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRI---SPL 433
Query: 284 PQDSKGIHAPSEGWS----------------------ALPLSAPSGNASGRPLSQLLNLD 321
+D++ +A S + PL P A G+ L D
Sbjct: 434 VKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKAL------D 487
Query: 322 LSYNEIELIPDSFLEHLTSLCFLNLSRNC-LRTFEARRLGSLPCLMLLDLSHNAL----- 375
LS N I I + E+L + LNLS N + ++P + LDL++N L
Sbjct: 488 LSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNA 547
Query: 376 ---------ETLELGARA-----------------LGSLRTLLLQGNALRDLPPYTFANL 409
E L+L + +L+ L L N + L
Sbjct: 548 SALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES 607
Query: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-- 467
SL L GNR+ D+ F G+ +L L L N ++ + AFL+ P
Sbjct: 608 KSLVELVFSGNRLDILWNDDDNRYISI--FKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS 665
Query: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAENRL 526
LTEL ++ N L+ L LE+L L+GN L+ L L F L+ L L+ NR+
Sbjct: 666 LTELHINDNM-LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRI 724
Query: 527 SHLPA--WTQAVSLEVLDLRNNSFSLLPGSAM-GGLETSLRRLYLQGNPLSC-CGNG--- 579
SHLP+ ++ SL+ LDL +N + SA+ T L L L GNP C C G
Sbjct: 725 SHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFR 784
Query: 580 -WLAAQLHQGRVDVDATQDLICRF-SSQEEVSLSHVRPEDCEKGGLKNINLIII--LTFI 635
W+ L+ V + D+IC Q S+ + C + ++ +I+ TF
Sbjct: 785 RWMDEHLN---VKIPRLVDVICASPGDQRGKSIVSLELTTC----VSDVTAVILFFFTFF 837
Query: 636 LVSAILLTTLA 646
+ + ++L LA
Sbjct: 838 ITTMVMLAALA 848
Score = 67.8 bits (164), Expect = 3e-11
Identities = 140/551 (25%), Positives = 219/551 (39%), Gaps = 81/551 (14%)
Query: 50 DTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
D+ + S +L+ + +G Y LDLS N I+ + +FQ L +L ++L HN
Sbjct: 43 DSVIAECSNRRLQEV-PQTVGKYVT--ELDLSDNFITHITNESFQGLQNLTKINLNHNPN 99
Query: 110 AM-----------ATALSAGGLGPLPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLS 155
++ G L + L L N L SGL E SL LS
Sbjct: 100 VQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE-------SLTELS 152
Query: 156 LAENSLTRLTRHTFRDMPALEQLDLHSNVLMD-------IEDGAFEGLPRLTHLNLSRNS 208
L +N++ +T+ + L+ L L N + IEDG FE L L L+LS NS
Sbjct: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212
Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--KLLHFP------- 259
L+ + LR L LS I+ + + + LT LDL N + + P
Sbjct: 213 LSHVPPKLPSSLRKLFLSNTQIK-YISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCD 271
Query: 260 ----------DLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAPSGN 308
L +L YLNLS+ +R + ++ + ++ L SG
Sbjct: 272 GGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASG- 330
Query: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
A L +L LDLS+N I+ S+ +H+ N+SRN + R L L +
Sbjct: 331 AFLTMLPRLEILDLSFNYIK---GSYPQHI------NISRNFSKLLSLRAL-HLRGYVFQ 380
Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
+L + + L L +L T+ L N ++ + F N ++L+ + L NR+SP
Sbjct: 381 ELREDDFQPL----MQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
Query: 429 DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE---------LDLSSNPGL 479
+ +F +R D E + PL + LDLS N
Sbjct: 437 TRQSYANSSSFQ--RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIF 494
Query: 480 EVATGALGGL-EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRL--SHLPAWTQAV 536
+ L + + L+ N ++ + +K L+L NRL + A T+
Sbjct: 495 FIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELS 554
Query: 537 SLEVLDLRNNS 547
LEVLDL NS
Sbjct: 555 DLEVLDLSYNS 565
Score = 61.6 bits (148), Expect = 2e-09
Identities = 80/268 (29%), Positives = 119/268 (44%), Gaps = 38/268 (14%)
Query: 24 VPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN 83
+ C + + QVL + ++ P + LDL+ N+L AS L + L LDLS N
Sbjct: 507 IACLNLSANSNAQVLSGTEFSAI--PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564
Query: 84 EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLER 143
F G +TH HL N + L+LS N++Y+ L ++
Sbjct: 565 SHYFRIAG----VTH--HLEFIQN---------------FTNLKVLNLSHNNIYT-LTDK 602
Query: 144 LLGEAPSLHTLSLAENSLTRLTR-------HTFRDMPALEQLDLHSNVLMDIEDGAFEGL 196
E+ SL L + N L L F+ + L +LDL N L I + AF L
Sbjct: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
Query: 197 P-RLTHLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 252
P LT L+++ N L + LQQ L +LDL N + F T S L L L
Sbjct: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLLSH 721
Query: 253 NKLLHFPD--LAALPRLIYLNLSNNLIR 278
N++ H P L+ + L +L+LS+NL++
Sbjct: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLK 749
Score = 29.6 bits (65), Expect = 9.3
Identities = 31/125 (24%), Positives = 55/125 (44%), Gaps = 13/125 (10%)
Query: 448 LSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL 506
L L DN I + +F LT+++L+ NP ++ G G +Q NGL +
Sbjct: 68 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG----------IQSNGLNIT 117
Query: 507 QVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
L+ L L +N+L +P+ E+ ++NN +++ + +L+ L
Sbjct: 118 DGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLI--NLKNL 175
Query: 567 YLQGN 571
YL N
Sbjct: 176 YLAWN 180
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 110 bits (275), Expect = 4e-24
Identities = 116/398 (29%), Positives = 171/398 (42%), Gaps = 55/398 (13%)
Query: 6 LLLLALLTLGLAAQHQDKVP----CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
+L L LL L A P C + + V+C L VP +P +T L+LS N++
Sbjct: 7 VLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRI 66
Query: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
R + L AL LDLS N I+ ++PGAF L L L L N+L + + G
Sbjct: 67 RCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKL---IPPGVFT 123
Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
L +T LDLS EN L L +TF+D+ +L +L++
Sbjct: 124 RLDNLTLLDLS-------------------------ENKLVILLDYTFQDLHSLRRLEVG 158
Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQA 241
N L+ + AF GL L L L R +LT +S SL LR L + AS
Sbjct: 159 DNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLR--SLGALRLRHLAIASLEDQ 216
Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
F+ LP L++L + N + L +G++ S +
Sbjct: 217 NFR------------------RLPGLLHLEIDNWPL-LEEVAAGSLRGLNLTSLSVTHTN 257
Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
++A A+ R + L L+LS+N I +P L L L+L+ L E +
Sbjct: 258 ITAVPA-AALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLG 316
Query: 362 LPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNAL 398
L + LL+LS+N L TLE ++ +L TL + GN L
Sbjct: 317 LRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 49.3 bits (116), Expect = 1e-05
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 29/191 (15%)
Query: 367 LLDLSHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPC 425
LL+LS N + L G AL +L L L NA+ + P FANL L+ L L+GN++
Sbjct: 58 LLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLI 117
Query: 426 GGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF--LHTPLTELDLSSNPGLEVAT 483
PG F+ + +L L L +N++ +L F LH+ L L++ N + V+
Sbjct: 118 ----PPG-----VFTRLDNLTLLDLSENKLVILLDYTFQDLHS-LRRLEVGDNDLVFVSR 167
Query: 484 GALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRL-NLAENRLSHLPAWTQAVSLEVLD 542
A GL A LE L L+ L L + L L +L RL H L +
Sbjct: 168 RAFAGLLA-LEELTLERCNLTALSGE-----SLGHLRSLGALRLRH---------LAIAS 212
Query: 543 LRNNSFSLLPG 553
L + +F LPG
Sbjct: 213 LEDQNFRRLPG 223
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 108 bits (270), Expect = 2e-23
Identities = 105/378 (27%), Positives = 169/378 (44%), Gaps = 50/378 (13%)
Query: 2 RPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
+P + L + L+ +G + C +K VSC L+ +P +P +T+ LDLS N+L
Sbjct: 10 QPFLGLAVVLIFMGSTIGCPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRL 69
Query: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
+S+ Y L +DLS N I+ ++PGAF L +L L L NRL +
Sbjct: 70 KSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLV--------- 120
Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
PL +++GL +L L ++EN + L + F+D+ L+ L++
Sbjct: 121 PL-----------GVFTGL--------SNLTKLDISENKIVILLDYMFQDLHNLKSLEVG 161
Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQA 241
N L+ I AF GL L L L + +LT + +L LR L ++ + P
Sbjct: 162 DNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLR--SLISLHLKHLNINNMPVY 219
Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
F+ + L+ ++ ++P L +P +N+L L + + + S +P
Sbjct: 220 AFKRLF-HLKHLEIDYWPLLDMMP-------ANSLYGL------NLTSLSVTNTNLSTVP 265
Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
A + L L +L+LSYN I I L L L++ LRT E
Sbjct: 266 FLA------FKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQG 319
Query: 362 LPCLMLLDLSHNALETLE 379
L L +L++S N LETLE
Sbjct: 320 LRFLRVLNVSQNLLETLE 337
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/242 (26%), Positives = 107/242 (44%), Gaps = 28/242 (11%)
Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLP 402
L+LS+N L++ S P L +DLS N + +E GA L +LR+L L+GN L+ +P
Sbjct: 62 LDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVP 121
Query: 403 PYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGA 462
F L++L +L++ N++ F + +L+SL + DN++ + A
Sbjct: 122 LGVFTGLSNLTKLDISENKIVILLD---------YMFQDLHNLKSLEVGDNDLVYISHRA 172
Query: 463 FLH-TPLTELDLSSNPGLEVATGALGGLEA--SLEVLALQGNGLMVLQVDLPCFICLKRL 519
F L +L L V T AL L + SL + L N ++P + +
Sbjct: 173 FSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNIN-------NMPVYAFKRLF 225
Query: 520 NLAENRLSHLPAWTQ-------AVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNP 572
+L + + P ++L L + N + S +P A L L L L NP
Sbjct: 226 HLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHL-VYLTHLNLSYNP 284
Query: 573 LS 574
+S
Sbjct: 285 IS 286
Score = 47.4 bits (111), Expect = 4e-05
Identities = 52/180 (28%), Positives = 83/180 (46%), Gaps = 7/180 (3%)
Query: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAH-NRLA 110
E L L L ++ L +L L L I+ + AF+ L HL+HL + + L
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLD 239
Query: 111 MATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
M A S GL +TSL ++ +L S + L L+L+ N ++ + F
Sbjct: 240 MMPANSLYGLN----LTSLSVTNTNL-STVPFLAFKHLVYLTHLNLSYNPISTIEAGMFS 294
Query: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLD-LSCNS 229
D+ L++L + L IE +F+GL L LN+S+N L + + R L+ LS N+
Sbjct: 295 DLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINN 354
Score = 35.0 bits (79), Expect = 0.22
Identities = 45/221 (20%), Positives = 80/221 (36%), Gaps = 38/221 (17%)
Query: 37 VLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQAL 96
+L ++ S+ + +L ++ L ++ L HL+LS N IS ++ G F L
Sbjct: 237 LLDMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDL 296
Query: 97 THLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSL 156
L+ L + +L S GL L L++
Sbjct: 297 IRLQELHIVGAQLRTIEPHSFQGL----------------------------RFLRVLNV 328
Query: 157 AENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFS 216
++N L L + F ALE L +++N L + L R L C +
Sbjct: 329 SQNLLETLEENVFSSPRALEVLSINNNPLA-CDCRLLWILQRQPTLQFGGQQPMCAGPDT 387
Query: 217 LQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLH 257
+++ D ++ + T +P+ +RE KL H
Sbjct: 388 IRERSFKDFHSTALSFYFTCKKPK---------IREKKLQH 419
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 108 bits (270), Expect = 2e-23
Identities = 126/490 (25%), Positives = 202/490 (41%), Gaps = 76/490 (15%)
Query: 1 MRPQILLLLALLTLGLAAQHQDKVP--CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSG 58
+R ++ L LAL ++ L+ P C V C LGL VP +P + E LDL
Sbjct: 12 VRARLALALALASV-LSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDR 70
Query: 59 NQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAG 118
N + I LR L L N++S ++ GAFQ L LE L L N+L +
Sbjct: 71 NNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQV------- 123
Query: 119 GLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
L E L P L L L+EN + + R FR + ++ L
Sbjct: 124 ---------------------LPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNL 162
Query: 179 DLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT--CISDFS-LQQLRVLDLSCNSIEAFQT 235
L +N + IEDGAF L L L L+ N+++ ++ F+ + ++R L L N +
Sbjct: 163 QLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL----- 217
Query: 236 ASQPQAEFQLTWLD--LRENKLLHFPDLAALP-RLIYLNLSNNLIRLPTGPPQDSKGIHA 292
+ L WL LR+ + + L P L N+++ + P H+
Sbjct: 218 ----YCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP-----HS 268
Query: 293 PSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLR 352
+A +S PS + +D + IP + E + + L +N ++
Sbjct: 269 EPPSCNANSISCPSPCTCSNNI-----VDCRGKGLMEIPANLPEGIVE---IRLEQNSIK 320
Query: 353 TFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLAS 411
A L +D+S N + + A + L SL +L+L GN + ++ F L S
Sbjct: 321 AIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVS 380
Query: 412 LQRLNLQGNRVSPCGGPDEPGPSGCV---AFSGITSLRSLSLVDNEIELLRAGAFLH-TP 467
LQ L L N+++ C+ F + +L LSL DN+++ + G F
Sbjct: 381 LQLLLLNANKIN------------CLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQS 428
Query: 468 LTELDLSSNP 477
+ L L+ NP
Sbjct: 429 IQTLHLAQNP 438
Score = 104 bits (260), Expect = 2e-22
Identities = 146/613 (23%), Positives = 231/613 (37%), Gaps = 112/613 (18%)
Query: 25 PCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNE 84
PC + V C+ GL+++P+ LP + L N +++I A Y L+ +D+S N+
Sbjct: 283 PCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQ 342
Query: 85 ISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL 144
IS + P AFQ L L L L N++ T ++ G L+ GL+
Sbjct: 343 ISDIAPDAFQGLKSLTSLVLYGNKI---TEIAKG-----------------LFDGLV--- 379
Query: 145 LGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNL 204
SL L L N + L +TF+D+ L L L+ N L I G F L + L+L
Sbjct: 380 -----SLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHL 434
Query: 205 SRNSLTC----------------------------ISDFSLQQLRVLDLSCNSIEAFQTA 236
++N C +++ + Q++ C+ E +++
Sbjct: 435 AQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSR 494
Query: 237 SQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
+ L P+ I + L+R+P+ P+ +
Sbjct: 495 FSSECFMDLV-----------CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNE 543
Query: 297 WSALPLSAPSGNASG--RPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF 354
S L A+G + L L ++LS N+I+ + + + S+ L L+ N L T
Sbjct: 544 VSVL-------EATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETV 596
Query: 355 EARRLGSLPCLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANLASLQ 413
R L L L L N + + A L S+R L L N + + P F L SL
Sbjct: 597 HGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLS 656
Query: 414 RLNLQGN-----------------RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD---- 452
+NL N R G P P F ++ +++ D
Sbjct: 657 TINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKP----FFLKEIPIQDVAIQDFTCD 712
Query: 453 -NEIELLRAGAFLHTPLTELDL---SSNPGLEVATGALGGLEASLEVLALQGNGLMVLQV 508
NE + T ++ SN GL G+ + L L+GN L +
Sbjct: 713 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALP---RGMPKDVTELYLEGNHLTAVPR 769
Query: 509 DLPCFICLKRLNLAENRLSHLPAWT--QAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
+L L ++L+ N +S L +T L L L N +P A GL SLR L
Sbjct: 770 ELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLR-SLRVL 828
Query: 567 YLQGNPLSCCGNG 579
L GN +S G
Sbjct: 829 TLHGNDISSVPEG 841
Score = 72.8 bits (177), Expect = 1e-12
Identities = 103/463 (22%), Positives = 163/463 (35%), Gaps = 145/463 (31%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTAL---RHLDLST 82
C+ V C L+++PS LP L L+ N++ + A+ G + L R ++LS
Sbjct: 509 CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEAT--GIFKKLPNLRKINLSN 566
Query: 83 NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
N+I ++ GAF ++ L L N+L GL
Sbjct: 567 NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLS--------------------- 605
Query: 143 RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
L TL L N + ++ TF + ++ L L+ N + I GAF L L+ +
Sbjct: 606 -------GLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTI 658
Query: 203 NLSRNSLTC----------------------------ISDFSLQQLRVLDLSCNSIEAFQ 234
NL N C + + +Q + + D +C+ E
Sbjct: 659 NLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESS 718
Query: 235 TASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAP 293
P+ Q T ++ + SN +R LP G P+D
Sbjct: 719 CQLSPRCPEQCTCMET------------------VVRCSNKGLRALPRGMPKD------- 753
Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
+ L L N + +P
Sbjct: 754 -----------------------VTELYLEGNHLTAVP---------------------- 768
Query: 354 FEARRLGSLPCLMLLDLSHNALETL-ELGARALGSLRTLLLQGNALRDLPPYTFANLASL 412
R L +L L L+DLS+N++ L + L TL+L N LR +P + F L SL
Sbjct: 769 ---RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSL 825
Query: 413 QRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEI 455
+ L L GN +S P G +F+ +TSL L+L N +
Sbjct: 826 RVLTLHGNDISSV-------PEG--SFNDLTSLSHLALGTNPL 859
Score = 57.8 bits (138), Expect = 3e-08
Identities = 91/367 (24%), Positives = 145/367 (39%), Gaps = 57/367 (15%)
Query: 126 VTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVL 185
VT L L+ N + + + P+L ++L+ N + + F ++++L L N L
Sbjct: 534 VTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 593
Query: 186 MDIEDGAFEGLPRLTHLNLSRNSLTCISDFS---LQQLRVLDLSCNSIEAFQTASQPQAE 242
+ F GL L L L N + C+S+ + L +R+L L N I T
Sbjct: 594 ETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTI-TPGAFTTL 652
Query: 243 FQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPL 302
L+ ++L N LA L + + R+ +G P+ K
Sbjct: 653 VSLSTINLLSNPFNCNCHLAWLGKWLRKR------RIVSGNPRCQKPFFLKEI------- 699
Query: 303 SAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTF---EARRL 359
P+ + D + + E C C+ T + L
Sbjct: 700 ----------PIQDVAIQDFTCDGNEESSCQLSPRCPEQC------TCMETVVRCSNKGL 743
Query: 360 GSLPCLMLLDLSHNALETLELGA--RALGSLRTLLL---QGNALRDLPPYTFANLASLQR 414
+LP M D++ LE L A R L +LR L L N++ L YTF+N++ L
Sbjct: 744 RALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLST 803
Query: 415 LNLQGNRVSPCGGPDEPGPSGCV---AFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTE 470
L L NR+ C+ AF+G+ SLR L+L N+I + G+F T L+
Sbjct: 804 LILSYNRLR------------CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851
Query: 471 LDLSSNP 477
L L +NP
Sbjct: 852 LALGTNP 858
Score = 56.2 bits (134), Expect = 9e-08
Identities = 51/195 (26%), Positives = 74/195 (37%), Gaps = 55/195 (28%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C ++ V C GL +P +P D L L GN L ++
Sbjct: 729 CTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV--------------------- 767
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
P AL HL + L++N ++M T N +S +
Sbjct: 768 ----PRELSALRHLTLIDLSNNSISMLT--------------------NYTFSNMSH--- 800
Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
L TL L+ N L + H F + +L L LH N + + +G+F L L+HL L
Sbjct: 801 -----LSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALG 855
Query: 206 RNSLTCISDFSLQQL 220
N L C D SL+ L
Sbjct: 856 TNPLHC--DCSLRWL 868
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 105 bits (263), Expect = 1e-22
Identities = 167/638 (26%), Positives = 256/638 (40%), Gaps = 104/638 (16%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C + + C L L QVP LP + L+L+ NQLR + A+ Y+ L LD+ N I
Sbjct: 28 CTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI 87
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL--------- 136
S L+P Q L L+ L+L HN L+ LS +T L L NS+
Sbjct: 88 SKLEPELCQKLPMLKVLNLQHNELSQ---LSDKTFAFCTNLTELHLMSNSIQKIKNNPFV 144
Query: 137 -----------YSGLLERLLG---EAPSLHTLSLAENSLTRLTRHTFRDMP--ALEQLDL 180
++GL LG + +L L L+ N + L +L++L+L
Sbjct: 145 KQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLEL 204
Query: 181 HSNVLMDIEDGAFEGLPRL---------------------------THLNLSRNSLTCIS 213
SN + + G F + RL +L+LS + L+ S
Sbjct: 205 SSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTS 264
Query: 214 DFSLQQLR-----VLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHF--PDLAALPR 266
+ + L+ +LDLS N++ S QL + L N + H L L
Sbjct: 265 NTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLP-QLEYFFLEYNNIQHLFSHSLHGLFN 323
Query: 267 LIYLNLSNNL----IRLPTGPPQDSKGI-------HAPSEGWSALPLSAPSGNASGRPLS 315
+ YLNL + I L + P D H E + +P S +G
Sbjct: 324 VRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMED-NDIP-GIKSNMFTGLINL 381
Query: 316 QLLNLDLSYNEIELIPDSFLEHL--TSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHN 373
+ L+L S+ + + + L + L LNL++N + E+ L L +LDL N
Sbjct: 382 KYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLN 441
Query: 374 ALETLELGA--RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEP 431
+ G R L ++ + L N L +FA + SLQRL L+ RV+ P
Sbjct: 442 EIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLR--RVALKNVDSSP 499
Query: 432 GPSGCVAFSGITSLRSLSLVDNEI-----------ELLRAGAFLHTPLTELDLSSNPGLE 480
P F + +L L L +N I E L H L L +NPG
Sbjct: 500 SP-----FQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGP 554
Query: 481 VATGALGGLEASLEVLALQGNGLMVLQVDL-PCFICLKRLNLAENRLSHLPA--WTQAVS 537
+ L GL + L +L L+ NG + V++ LK ++L N L+ LPA + VS
Sbjct: 555 IYF--LKGL-SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVS 611
Query: 538 LEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC 575
L+ L+L+ N + + G +L L ++ NP C
Sbjct: 612 LKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDC 649
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 105 bits (261), Expect = 2e-22
Identities = 125/463 (26%), Positives = 188/463 (40%), Gaps = 93/463 (20%)
Query: 35 CQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQ 94
C LGL VP L P T LDLS N L + L L LS N +S + AF
Sbjct: 52 CSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 111
Query: 95 ALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSL-------YSGLLE----- 142
L L+ L L +N+L + A L LP + SL L N + + GL
Sbjct: 112 GLYSLKILMLQNNQLG---GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLW 168
Query: 143 -----------RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDG 191
R L P+L ++LA N ++ + + F+++ +L L LH+N + +
Sbjct: 169 LDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTH 228
Query: 192 AFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLR 251
+FEG L L LDL+ N ++ F A + Q L
Sbjct: 229 SFEG---------------------LHNLETLDLNYNKLQEFPVAIRTLGRLQ--ELGFH 265
Query: 252 ENKLLHFPDLAAL--PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNA 309
N + P+ A + P L ++ +N I+ G +
Sbjct: 266 NNNIKAIPEKAFMGNPLLQTIHFYDNPIQF--------------------------VGRS 299
Query: 310 SGRPLSQLLNLDLS-YNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
+ + L +L L L+ +I+ PD L+ TSL L L+R +R + LP L +L
Sbjct: 300 AFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVL 357
Query: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
+LSHN +E L L + LQ N + ++ TF+ L+SLQ L+L N + P
Sbjct: 358 ELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI-HP 415
Query: 429 DEPGPSGCVAFSGITSLRSLSLVDNE---IELLRAGAFLHTPL 468
+ AFS + SL L L DN+ + L G +H L
Sbjct: 416 E--------AFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKL 450
Score = 86.7 bits (213), Expect = 6e-17
Identities = 120/425 (28%), Positives = 173/425 (40%), Gaps = 63/425 (14%)
Query: 173 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEA 232
P LDL N L +++ G F L L L LS N L+ I + L
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL------------ 113
Query: 233 FQTASQPQAEFQLTWLDLRENKLLHFPDLAA--LPRLIYLNLSNNLIRLPTGPPQDSKGI 290
+ L L L+ N+L P A LP L L L NLI L P + +G+
Sbjct: 114 ----------YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLV--PERSFEGL 161
Query: 291 HAPSEGW------SALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFL 344
+ W + +P+ A + L L + L+ N I IPD ++LTSL L
Sbjct: 162 SSLRHLWLDDNALTEIPVRALNN------LPALQAMTLALNRISHIPDYAFQNLTSLVVL 215
Query: 345 NLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPY 404
+L N ++ L L LDL++N L+ + R LG L+ L N ++ +P
Sbjct: 216 HLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEK 275
Query: 405 TFANLASLQRLNLQGNRVSPCGGP-----------DEPGPSGCVAF---SGITSLRSLSL 450
F LQ ++ N + G G F G TSL L+L
Sbjct: 276 AFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTL 335
Query: 451 VDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD 509
I LL +G P L L+LS N E+ +L + LE + LQ N + + D
Sbjct: 336 TRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQ-KLEEIGLQHNRIWEIGAD 392
Query: 510 -LPCFICLKRLNLAEN--RLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL 566
L+ L+L+ N R H A++ SL LDL +N + LP + +GG L L
Sbjct: 393 TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG----LMHL 448
Query: 567 YLQGN 571
L+GN
Sbjct: 449 KLKGN 453
Score = 39.3 bits (90), Expect = 0.012
Identities = 31/83 (37%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
E + L N++ I A ++L+ LDLS N I + P AF L L L L N+L
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL-- 434
Query: 112 ATALSAGGLGPLPRVTSLDLSGN 134
T L GLG L L L GN
Sbjct: 435 -TTLPLAGLGGL---MHLKLKGN 453
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 104 bits (260), Expect = 2e-22
Identities = 128/432 (29%), Positives = 192/432 (44%), Gaps = 34/432 (7%)
Query: 123 LPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHS 182
L ++T L L N L S L +G +L TL+L+ENSLT L + ++ L LDL
Sbjct: 122 LTQLTELYLYSNKLQS--LPAEVGCLVNLMTLALSENSLTSLP-DSLDNLKKLRMLDLRH 178
Query: 183 NVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTASQPQ 240
N L +I + L LT L L N +T + +L +L +L + N I+ Q ++
Sbjct: 179 NKLREIPSVVYR-LDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIK--QLPAEIG 235
Query: 241 AEFQLTWLDLRENKLLHFP-DLAALPRLIYLNLSNN-LIRLPT--GPPQDSKGIHAPSEG 296
L LD+ N+L H P ++ ++ L+L +N L+ LP G +
Sbjct: 236 ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNR 295
Query: 297 WSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
SA+P S +A L L+L N I +P+S L L L L L+RNC + +
Sbjct: 296 LSAIPRSLAKCSA-------LEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPV 348
Query: 357 RRLGSLPCLMLLDLSHNALETLELGARALGS-LRTLLLQGNALRDLPPYTFANLASLQRL 415
+ L++ HN + + G + L L ++ N L L P F S+ L
Sbjct: 349 GGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTWTSMVEL 407
Query: 416 NLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSS 475
NL N+++ P++ SG+ SL L L +N ++ L G L ELDL
Sbjct: 408 NLATNQLTKI--PED--------VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEE 457
Query: 476 NPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQA 535
N LE + L+ L+ L L N L L + L L L EN L+HLP
Sbjct: 458 NK-LESLPNEIAYLK-DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGT 515
Query: 536 V-SLEVLDLRNN 546
+ +LE L L +N
Sbjct: 516 LENLEELYLNDN 527
Score = 84.7 bits (208), Expect = 2e-16
Identities = 115/398 (28%), Positives = 170/398 (42%), Gaps = 58/398 (14%)
Query: 202 LNLSRNSLTCI--SDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFP 259
L+LS+ S+ + S L QL L L N +++ ++ L L L EN L P
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLP--AEVGCLVNLMTLALSENSLTSLP 162
Query: 260 D-LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
D L L +L L+L +N +R PS + L L
Sbjct: 163 DSLDNLKKLRMLDLRHNKLR------------EIPSVVYR---------------LDSLT 195
Query: 319 NLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETL 378
L L +N I + + +++L+ L L++ N ++ A +G L L+ LD++HN LE L
Sbjct: 196 TLYLRFNRITTV-EKDIKNLSKLSMLSIRENKIKQLPAE-IGELCNLITLDVAHNQLEHL 253
Query: 379 ELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSP-------CGGPDEP 431
+ L LQ N L DLP T NL+SL RL L+ NR+S C +E
Sbjct: 254 PKEIGNCTQITNLDLQHNELLDLPD-TIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEEL 312
Query: 432 G---------PSGCVAFSGITSLRSLSLVDNEIELLRAGA-FLHTPLTELDLSSNPGLEV 481
P + S + L SL+L N +L G + + L++ N ++
Sbjct: 313 NLENNNISTLPESLL--SSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKI 370
Query: 482 ATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQA-VSLEV 540
G + L L ++ N L L +D + + LNLA N+L+ +P VSLEV
Sbjct: 371 PFGIFSRAKV-LSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEV 429
Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGN 578
L L NN LP +G L LR L L+ N L N
Sbjct: 430 LILSNNLLKKLP-HGLGNLR-KLRELDLEENKLESLPN 465
Score = 48.1 bits (113), Expect = 3e-05
Identities = 62/230 (26%), Positives = 92/230 (40%), Gaps = 38/230 (16%)
Query: 366 MLLDLSHNALETLELGARALGSLRTLLLQGNALRDLP----------------------P 403
M LDLS ++ L + L L L L N L+ LP P
Sbjct: 103 MRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162
Query: 404 YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAF-------------SGITSLRSLSL 450
+ NL L+ L+L+ N++ S + ++ L LS+
Sbjct: 163 DSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSI 222
Query: 451 VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDL 510
+N+I+ L A L LD++ N LE +G + L LQ N L+ L +
Sbjct: 223 RENKIKQLPAEIGELCNLITLDVAHNQ-LEHLPKEIGNC-TQITNLDLQHNELLDLPDTI 280
Query: 511 PCFICLKRLNLAENRLSHLP-AWTQAVSLEVLDLRNNSFSLLPGSAMGGL 559
L RL L NRLS +P + + +LE L+L NN+ S LP S + L
Sbjct: 281 GNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSL 330
Score = 46.6 bits (109), Expect = 7e-05
Identities = 52/156 (33%), Positives = 73/156 (46%), Gaps = 12/156 (7%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
L++ NQL S L G +T++ L+L+TN+++ + P L LE L L++N L
Sbjct: 384 LNMKDNQLTS-LPLDFGTWTSMVELNLATNQLTKI-PEDVSGLVSLEVLILSNNLLKKLP 441
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
GLG L ++ LDL N L S L + L L L N LT L R +
Sbjct: 442 H----GLGNLRKLRELDLEENKLES--LPNEIAYLKDLQKLVLTNNQLTTLPR-GIGHLT 494
Query: 174 ALEQLDLHSNVLMDI--EDGAFEGLPRLTHLNLSRN 207
L L L N+L + E G E L L +LN + N
Sbjct: 495 NLTHLGLGENLLTHLPEEIGTLENLEEL-YLNDNPN 529
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 103 bits (256), Expect = 7e-22
Identities = 110/366 (30%), Positives = 152/366 (41%), Gaps = 71/366 (19%)
Query: 2 RPQILLLLALLTLGL---------AAQHQDKVPCKMVDK--KVSCQVLGLLQVPSVLPPD 50
R ++LLL + LGL A C V++ V C GLL+VP+ LP +
Sbjct: 4 RGMLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCE 63
Query: 51 TETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLA 110
++DL N LR + G +LR L L N +SF+ PGAF+ L L L LAHN
Sbjct: 64 AVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHN--G 121
Query: 111 MATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFR 170
L A L R+ LDL+ L+S + ERLL E P+L L+ +N FR
Sbjct: 122 DLRYLHARTFAALSRLRRLDLAACRLFS-VPERLLAELPALRELAAFDN--------LFR 172
Query: 171 DMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ---QLRVLDLSC 227
+P GA GL LTH +L R + ++ SLQ +LR L L
Sbjct: 173 RVP-----------------GALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQA 215
Query: 228 NSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLA--ALPRLIYLNLSNNLIRLPTGPPQ 285
N + A + L L L +N L P A L RL LNL N
Sbjct: 216 NRVRAVHAGAFGDCGV-LEHLLLNDNLLAELPADAFRGLRRLRTLNLGGN---------- 264
Query: 286 DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLN 345
+ + W A L++L L L N I + + ++L+ L L+
Sbjct: 265 ---ALDRVARAWFA-------------DLAELELLYLDRNSIAFVEEGAFQNLSGLLALH 308
Query: 346 LSRNCL 351
L+ N L
Sbjct: 309 LNGNRL 314
Score = 66.2 bits (160), Expect = 9e-11
Identities = 61/188 (32%), Positives = 89/188 (47%), Gaps = 27/188 (14%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
LDL+ +L S+ L ALR L N + PGA + L +L H L R+
Sbjct: 140 LDLAACRLFSVPERLLAELPALRELAAFDNLFRRV-PGALRGLANLTHAHLERGRIE--- 195
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYS---------GLLERLL------GEAPS-------- 150
A+++ L L R+ SL L N + + G+LE LL E P+
Sbjct: 196 AVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRR 255
Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT 210
L TL+L N+L R+ R F D+ LE L L N + +E+GAF+ L L L+L+ N LT
Sbjct: 256 LRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315
Query: 211 CISDFSLQ 218
++ + Q
Sbjct: 316 VLAWVAFQ 323
Score = 60.8 bits (146), Expect = 4e-09
Identities = 75/241 (31%), Positives = 97/241 (40%), Gaps = 34/241 (14%)
Query: 344 LNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNA-LRDL 401
++L RN LR R G+LP L L L HN L + GA + L L L L N LR L
Sbjct: 67 IDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYL 126
Query: 402 PPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAG 461
TFA L+ L+RL+L R+ P+ + + +LR L+ DN +
Sbjct: 127 HARTFAALSRLRRLDLAACRLFSV--PER-------LLAELPALRELAAFDNLFRRVPGA 177
Query: 462 AFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNL 521
LT L VA+ +L GL L L+LQ N +
Sbjct: 178 LRGLANLTHAHLERGRIEAVASSSLQGLR-RLRSLSLQANRV------------------ 218
Query: 522 AENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWL 581
R H A+ LE L L +N + LP A GL LR L L GN L W
Sbjct: 219 ---RAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLR-RLRTLNLGGNALDRVARAWF 274
Query: 582 A 582
A
Sbjct: 275 A 275
Score = 53.5 bits (127), Expect = 6e-07
Identities = 83/278 (29%), Positives = 111/278 (39%), Gaps = 26/278 (9%)
Query: 316 QLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
+ +++DL N + + + L SL L+L N L LP L L L+HN
Sbjct: 63 EAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNG- 121
Query: 376 ETLELGAR---ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPG 432
+ L AR AL LR L L L +P A L +L+ L N G
Sbjct: 122 DLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPG----- 176
Query: 433 PSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNPGLEVATGALGGLEA 491
A G+ +L L IE + + + L L L +N V GA G
Sbjct: 177 -----ALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDC-G 230
Query: 492 SLEVLALQGNGLMVLQVDLPCFICLKR---LNLAENRLSHLP-AW-TQAVSLEVLDLRNN 546
LE L L N L L D F L+R LNL N L + AW LE+L L N
Sbjct: 231 VLEHLLLNDNLLAELPAD--AFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRN 288
Query: 547 SFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQ 584
S + + A L + L L+L GN L+ W+A Q
Sbjct: 289 SIAFVEEGAFQNL-SGLLALHLNGNRLTVL--AWVAFQ 323
Score = 53.1 bits (126), Expect = 8e-07
Identities = 53/180 (29%), Positives = 77/180 (42%), Gaps = 10/180 (5%)
Query: 56 LSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATAL 115
L ++ ++ +S L LR L L N + + GAF LEHL L N LA L
Sbjct: 189 LERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLA---EL 245
Query: 116 SAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPAL 175
A L R+ +L+L GN+L + + L L L NS+ + F+++ L
Sbjct: 246 PADAFRGLRRLRTLNLGGNAL-DRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGL 304
Query: 176 EQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC------ISDFSLQQLRVLDLSCNS 229
L L+ N L + AF+ L L L RN C + D+ RV D+ C S
Sbjct: 305 LALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCAS 364
Score = 45.8 bits (107), Expect = 1e-04
Identities = 76/270 (28%), Positives = 105/270 (38%), Gaps = 54/270 (20%)
Query: 248 LDLRENKLLHFPDLA--ALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAP 305
L LR N L A LPRL L L++N D + +HA +
Sbjct: 91 LSLRHNNLSFITPGAFKGLPRLAELRLAHN---------GDLRYLHARTFA--------- 132
Query: 306 SGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCL 365
LS+L LDL+ + +P+ L L +L L N R G
Sbjct: 133 -------ALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG----- 180
Query: 366 MLLDLSHNALETLELGARALGS------LRTLLLQGNALRDLPPYTFANLASLQRLNLQG 419
L +L+H LE + A A S LR+L LQ N +R + F + L+ L L
Sbjct: 181 -LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLND 239
Query: 420 NRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELD---LSSN 476
N ++ AF G+ LR+L+L N ++ + F L EL+ L N
Sbjct: 240 NLLAELPAD---------AFRGLRRLRTLNLGGNALDRVARAWF--ADLAELELLYLDRN 288
Query: 477 PGLEVATGALGGLEASLEVLALQGNGLMVL 506
V GA L + L L L GN L VL
Sbjct: 289 SIAFVEEGAFQNL-SGLLALHLNGNRLTVL 317
Score = 36.6 bits (83), Expect = 0.076
Identities = 23/59 (38%), Positives = 31/59 (52%)
Query: 53 TLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
TL+L GN L + + L L L N I+F++ GAFQ L+ L L L NRL +
Sbjct: 258 TLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTV 316
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 102 bits (255), Expect = 9e-22
Identities = 109/369 (29%), Positives = 158/369 (42%), Gaps = 33/369 (8%)
Query: 123 LPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHS 182
+P T + + ++ L R G P+L + L + F +P LE L++
Sbjct: 47 IPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTG 106
Query: 183 NVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAE 242
+ +++ F L L L L+ N L + + Q L L+ ++ Q + P+
Sbjct: 107 SSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESL--HLQGNQLQALPRRL 164
Query: 243 FQ----LTWLDLRENKLLHFPD--LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEG 296
FQ L L+L +N L P+ L L L LSNN + +G PQ G +
Sbjct: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL---SGLPQGVFG-----KL 216
Query: 297 WSALPLSAPSGNASGRP---LSQLLNLD---LSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
S L S N S P SQL L+ L N I +P S L +L FL+L N
Sbjct: 217 GSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276
Query: 351 LRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGSLRTLLLQGNALRDLPPYTFANL 409
LR A PCL+ L L+HN LET+ G A L +LR+L+L NA+ LP F +L
Sbjct: 277 LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL 336
Query: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTPL 468
L +L L N ++ F ++ L LSL N++ L G F + L
Sbjct: 337 EELVKLYLGSNNLTALHP---------ALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
Query: 469 TELDLSSNP 477
L L NP
Sbjct: 388 FNLALHGNP 396
Score = 90.9 bits (224), Expect = 3e-18
Identities = 117/428 (27%), Positives = 171/428 (39%), Gaps = 52/428 (12%)
Query: 6 LLLLALLTLGLAAQHQDKVPCKM----VDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQL 61
LL +LL L AQ PC M ++V C L VP +PP T+ +
Sbjct: 7 LLWTSLLLLARPAQ-----PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSF 61
Query: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
++ G L + ++ +P AF L LE L + + LS
Sbjct: 62 TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSF---LNLSTNIFS 118
Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
L + L L+ N L L E L +L +L L N L L R F+ + L+ L+L
Sbjct: 119 NLTSLGKLTLNFNML-EALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLA 177
Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFQTASQ 238
N+L + + F L L L LS N+L+ + L L+ L L N+I
Sbjct: 178 QNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISEL----P 233
Query: 239 PQAEFQLTWLD---LRENKLLHFP--DLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAP 293
PQ QL L+ L+ N + H P A+L L +L+L N++R+
Sbjct: 234 PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRV-------------- 279
Query: 294 SEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT 353
P+G + P L+ L L++N++E + + HL++L L LS N +
Sbjct: 280 ----------LPAGLFAHTPC--LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
Query: 354 FEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASL 412
A L L+ L L N L L + L L L L N L LP F +L
Sbjct: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
Query: 413 QRLNLQGN 420
L L GN
Sbjct: 388 FNLALHGN 395
Score = 85.9 bits (211), Expect = 1e-16
Identities = 123/468 (26%), Positives = 167/468 (35%), Gaps = 133/468 (28%)
Query: 149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNS 208
P + E S T L F P L ++ + L AF GLPRL L ++ +S
Sbjct: 49 PYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSS 108
Query: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLI 268
L+LS N F +L +L +L
Sbjct: 109 F-------------LNLSTNI----------------------------FSNLTSLGKLT 127
Query: 269 YLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIE 328
LN N L LP G Q L+ L +L L N+++
Sbjct: 128 -LNF-NMLEALPEGLFQH---------------------------LAALESLHLQGNQLQ 158
Query: 329 LIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARA-LGS 387
+P + LT L LNL++N L L L L LS+NAL L G LGS
Sbjct: 159 ALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS 218
Query: 388 LRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRS 447
L+ L L N + +LPP F+ L L+RL LQ N ++ F+ + +L
Sbjct: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLP---------LSIFASLGNLTF 269
Query: 448 LSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVL 506
LSL N + +L AG F HTP L L L+ N VA G L
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSN--------------- 314
Query: 507 QVDLPCFICLKRLNLAENRLSHLPA--------------------------WTQAVSLEV 540
L+ L L+ N ++HLPA + LE+
Sbjct: 315 ---------LRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLEL 365
Query: 541 LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQ 587
L L N + LP + +L L L GNP C C +L L Q
Sbjct: 366 LSLSKNQLTTLP-EGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQ 412
Score = 51.6 bits (122), Expect = 2e-06
Identities = 63/212 (29%), Positives = 91/212 (42%), Gaps = 12/212 (5%)
Query: 8 LLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGL-LQVPSVLPPDTET----LDLSGNQLR 62
L +L TL L+ +P + K S Q L L S LPP + L+ Q
Sbjct: 192 LTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251
Query: 63 SILASPLGFYTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGG 119
+I PL + +L +L L N + L G F L LSL HN+L ++ G
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLE---TVAEGT 308
Query: 120 LGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLD 179
L + SL LS N++ + L + + L L L N+LT L F+++ LE L
Sbjct: 309 FAHLSNLRSLMLSYNAI-THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLS 367
Query: 180 LHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
L N L + +G F+ L +L L N C
Sbjct: 368 LSKNQLTTLPEGIFDTNYNLFNLALHGNPWQC 399
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 102 bits (254), Expect = 1e-21
Identities = 174/595 (29%), Positives = 231/595 (38%), Gaps = 100/595 (16%)
Query: 3 PQILLLLALLTLGLAAQHQ-DKVP----CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLS 57
P +L LL LL L A Q + P C + V+C+ L +VP +P T+ LDL
Sbjct: 11 PLVLPLLVLLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQ 70
Query: 58 GNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSA 117
GN L+ I A+ L HLDL E+ + GAF+ L L L+LA N L +
Sbjct: 71 GNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEAL 130
Query: 118 GGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQ 177
GLG L R L+L GN+L L G +L TL+LA N+L L F+ + +
Sbjct: 131 DGLGSLRR---LELEGNAL-EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRW 186
Query: 178 LDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTAS 237
L L N L + A GLP L L+L N L + L Q R
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQAR---------------- 230
Query: 238 QPQAEFQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE 295
L L+L N L + D ALP L L L ++ GP + H P
Sbjct: 231 ------GLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQ-ALGPRAFA---HCP-- 278
Query: 296 GWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRT-F 354
+L LDL N+++ +P L+ L L L N L
Sbjct: 279 --------------------RLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGC 316
Query: 355 EARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTF-------A 407
+AR L L A + G R L+G AL L P+
Sbjct: 317 QARPL----------LEWLARARVRSDGACQGPRR---LRGEALDALRPWDLRCPGDAAQ 363
Query: 408 NLASLQRLNLQGNRVSPCGGPDEPG--------PSGCVAFSGITSLRSLSLVDNEIELLR 459
L+ + G R P G P PG P CV + R S ++ +
Sbjct: 364 EEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVC---VPESRHSSCEGCGLQAVP 420
Query: 460 AGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVD-LPCFICLKR 518
G T L LDL N V A GL L L LQ G+ L+ L L
Sbjct: 421 RGFPSDTQL--LDLRRNHFPSVPRAAFPGL-GHLVSLHLQHCGIAELEAGALAGLGRLIY 477
Query: 519 LNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGN 571
L L++N+L+ L A A L L L N F +PG+A+ L SL L+LQ N
Sbjct: 478 LYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRAL-PSLFSLHLQDN 531
Score = 94.7 bits (234), Expect = 2e-19
Identities = 104/322 (32%), Positives = 132/322 (40%), Gaps = 43/322 (13%)
Query: 275 NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSF 334
NL +P P+ ++ + +P +A G + L +LDL + E+EL+ +
Sbjct: 52 NLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQG------VPHLTHLDLRHCEVELVAEGA 105
Query: 335 LEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLL 393
L L LNL+ N LR L L L L+L NALE L G ALG+L TL L
Sbjct: 106 FRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNL 165
Query: 394 QGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDN 453
NAL LP F L ++ L L N +S P+ A +G+ +LR LSL N
Sbjct: 166 AHNALVYLPAMAFQGLLRVRWLRLSHNALSVL-APE--------ALAGLPALRRLSLHHN 216
Query: 454 EIELLRAGAFLHT-PLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 512
E++ L L L+L NP L A G L L L G L
Sbjct: 217 ELQALPGPVLSQARGLARLELGHNP-LTYAGEEDGLALPGLRELLLDGGALQA------- 268
Query: 513 FICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNP 572
L +H P L LDLR N LP G LRRL LQGNP
Sbjct: 269 --------LGPRAFAHCP------RLHTLDLRGNQLDTLPPLQGPG---QLRRLRLQGNP 311
Query: 573 LSC-CGNGWLAAQLHQGRVDVD 593
L C C L L + RV D
Sbjct: 312 LWCGCQARPLLEWLARARVRSD 333
Score = 92.8 bits (229), Expect = 9e-19
Identities = 164/590 (27%), Positives = 229/590 (38%), Gaps = 76/590 (12%)
Query: 11 LLTLGLAAQHQDKVPCKMVDKKVSCQVLGLL-QVPSVLPPDT-------ETLDLSGNQLR 62
LL L LA+ H ++P + +D S + L L L P T TL+L+ N L
Sbjct: 112 LLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALV 171
Query: 63 SILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL--------AMATA 114
+ A +R L LS N +S L P A L L LSL HN L + A
Sbjct: 172 YLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARG 231
Query: 115 LSAGGLG-------------PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSL 161
L+ LG LP + L L G +L + L R P LHTL L N L
Sbjct: 232 LARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQA-LGPRAFAHCPRLHTLDLRGNQL 290
Query: 162 TRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR--NSLTC-----ISD 214
L + L +L L N L + P L L +R + C +
Sbjct: 291 DTLP--PLQGPGQLRRLRLQGNPLWC----GCQARPLLEWLARARVRSDGACQGPRRLRG 344
Query: 215 FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLR--------ENKLLHFPDLAA-LP 265
+L LR DL C A + + R E + P +P
Sbjct: 345 EALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERAVAPCPRACVCVP 404
Query: 266 RLIYLNLSN-NLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
+ + L +P G P D++ + + ++P +A G L L++L L +
Sbjct: 405 ESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPG------LGHLVSLHLQH 458
Query: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA-LETLELGAR 383
I + L L L +L LS N L A L P L L L N L+ R
Sbjct: 459 CGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALR 518
Query: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
AL SL +L LQ NA+ L P +L+ + L GNR++ A
Sbjct: 519 ALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVS---------LGALGPAR 569
Query: 444 SLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
L L L N++ + GA P L EL LS NP + GA + SL+ L L +G
Sbjct: 570 ELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSG 629
Query: 503 LMVLQVDLPCFICL----KRLNLAENRLSHLPAWTQAVSLEVLDLRNNSF 548
L Q+ F L + L+L +N+L LPA LE++DL +N F
Sbjct: 630 LE--QICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPF 677
Score = 79.3 bits (194), Expect = 1e-14
Identities = 147/548 (26%), Positives = 212/548 (38%), Gaps = 98/548 (17%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMA- 112
L LS N L + L ALR L L NE+ L L L L HN L A
Sbjct: 187 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAG 246
Query: 113 -----------TALSAGG----LGP-----LPRVTSLDLSGNSLYS-------GLLERLL 145
L GG LGP PR+ +LDL GN L + G L RL
Sbjct: 247 EEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLR 306
Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRD--------------MPALEQLDLH-----SNVLM 186
+ L A L L R R + AL DL +
Sbjct: 307 LQGNPLWCGCQARPLLEWLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEE 366
Query: 187 DIEDGAFEGLPRLTHLNLSRN--SLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ---A 241
++E+ A G PR R ++ + V + +S E + P+ +
Sbjct: 367 ELEERAVAG-PRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPS 425
Query: 242 EFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALP 301
+ QL LDLR N HFP ++PR + L + + +H G + L
Sbjct: 426 DTQL--LDLRRN---HFP---SVPRAAFPGLGHLV------------SLHLQHCGIAELE 465
Query: 302 LSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGS 361
A +G L +L+ L LS N++ + + LE L +L L RN L +
Sbjct: 466 AGALAG------LGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRA 519
Query: 362 LPCLMLLDLSHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN 420
LP L L L NA++ L G +LR + L GN + ++ L++L+L N
Sbjct: 520 LPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRN 579
Query: 421 RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF--LHTPLTELDLSSNPG 478
++ P+G A G+ +L L L N + LR GAF + L L L+S+
Sbjct: 580 QLREV-------PTG--ALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGL 630
Query: 479 LEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAEN------RLSHLPAW 532
++ GA GL L+ L LQ N L L LP L+ ++L+ N +L L W
Sbjct: 631 EQICPGAFSGLGPGLQSLHLQKNQLRALPA-LPSLSQLELIDLSSNPFHCDCQLLPLHRW 689
Query: 533 TQAVSLEV 540
++L V
Sbjct: 690 LTGLNLRV 697
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 101 bits (251), Expect = 3e-21
Identities = 122/447 (27%), Positives = 188/447 (42%), Gaps = 56/447 (12%)
Query: 15 GLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTA 74
G+AA+ C+ + + C L ++P LP LDLS N+L I AS + +
Sbjct: 40 GVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99
Query: 75 LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLP-RVTSLDLSG 133
LR + L+ NE+ + LGP+ +T L L+G
Sbjct: 100 LREVKLNNNELETIP-----------------------------NLGPVSANITLLSLAG 130
Query: 134 NSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 193
N + L E L E SL TL L+ N+++ L T L+ L L+SN + +E G F
Sbjct: 131 NRIVEILPEHLK-EFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYF 187
Query: 194 EGLPR-LTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDL 250
+ L L L L+RN ++ I F L QL+ L+L+ N I+ + Q L L +
Sbjct: 188 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTF-QGLGALKSLKM 246
Query: 251 RENKLLHFPDLA--ALPRLIYLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG 307
+ N + D A L + L L NNL + G + +A+ +P
Sbjct: 247 QRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDA 306
Query: 308 NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLML 367
+ LS+L DL++N + + DS L+ L L++ N + L L
Sbjct: 307 WEFCQKLSEL---DLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363
Query: 368 LDLSHN----ALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVS 423
LDL +N +E + L LR L+LQGN +R + F L +L+ L+L N +
Sbjct: 364 LDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIM 423
Query: 424 PCGGPDEPGPSGCVAFSGITSLRSLSL 450
G AFS + L+ L L
Sbjct: 424 SLQGN---------AFSQMKKLQQLHL 441
Score = 78.2 bits (191), Expect = 2e-14
Identities = 122/457 (26%), Positives = 191/457 (41%), Gaps = 82/457 (17%)
Query: 141 LERLLGEAPS-LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIED-GAFEGLPR 198
L RL PS + L L+ N L+ + + + +L ++ L++N L I + G
Sbjct: 65 LARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--N 122
Query: 199 LTHLNLSRNSLTCISDFSL---QQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKL 255
+T L+L+ N + I L Q L LDLS N+I QTA QL +L L N++
Sbjct: 123 ITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPA---LQLKYLYLNSNRV 179
Query: 256 L-----HFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNAS 310
+F +LA L+ L L+ N R+ PP+ K
Sbjct: 180 TSMEPGYFDNLANT--LLVLKLNRN--RISAIPPKMFK---------------------- 213
Query: 311 GRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDL 370
L QL +L+L+ N+I+ + + L +L L + RN + L + +L L
Sbjct: 214 ---LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQL 270
Query: 371 SHNALETLELG-ARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPD 429
HN L + G L L+ L L NA+ + P + L L+L N +S
Sbjct: 271 DHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDS- 329
Query: 430 EPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-TPLTELDLSSNP---GLEVATGA 485
+F G++ L +L + +N + + AF + L LDL +N +E GA
Sbjct: 330 --------SFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGA 381
Query: 486 LGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRN 545
GL+ L L LQGN + R A+T +LE LDL +
Sbjct: 382 FSGLD-KLRRLILQGNRI---------------------RSITKKAFTGLDALEHLDLSD 419
Query: 546 NSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CGNGWL 581
N+ L G+A ++ L++L+L + L C C WL
Sbjct: 420 NAIMSLQGNAFSQMK-KLQQLHLNTSSLLCDCQLKWL 455
Score = 70.5 bits (171), Expect = 5e-12
Identities = 51/163 (31%), Positives = 78/163 (47%), Gaps = 7/163 (4%)
Query: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
+ L LS N + I F L LDL+ N +S L +F L+ L L + +NR++
Sbjct: 290 QELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSY 349
Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGE---APSLHTLSLAENSLTRLTRHT 168
+ GL L +LDL N + S +E + G L L L N + +T+
Sbjct: 350 IADCAFRGLSSLK---TLDLKNNEI-SWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKA 405
Query: 169 FRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
F + ALE LDL N +M ++ AF + +L L+L+ +SL C
Sbjct: 406 FTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLC 448
Score = 55.5 bits (132), Expect = 2e-07
Identities = 84/348 (24%), Positives = 140/348 (40%), Gaps = 58/348 (16%)
Query: 302 LSAPSGNASGRPLSQLLN-----LDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEA 356
L PSG A+ RP LD S + +P+ + L +LS N L +A
Sbjct: 35 LGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARL---DLSHNRLSFIKA 91
Query: 357 RRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLN 416
+ L L + L++N LET+ ++ L L GN + ++ P SL+ L+
Sbjct: 92 SSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLD 151
Query: 417 LQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSN 476
L N +S E++ AF L L L+SN
Sbjct: 152 LSSNNIS------------------------------ELQT----AFPALQLKYLYLNSN 177
Query: 477 PGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWT-QA 535
+ G L +L VL L N + + + L+ L L N++ ++ T Q
Sbjct: 178 RVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQG 237
Query: 536 V-SLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWL-----AAQLHQ-- 587
+ +L+ L ++ N + L A GL +++ L L N L+ GWL +LH
Sbjct: 238 LGALKSLKMQRNGVTKLMDGAFWGL-SNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQ 296
Query: 588 ---GRVDVDATQDLICRFSSQEEVSLSHV-RPEDCEKGGLKNINLIII 631
R+ DA + C+ S+ +++ +H+ R +D GL +N + I
Sbjct: 297 NAINRISPDAWE--FCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI 342
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 101 bits (251), Expect = 3e-21
Identities = 102/339 (30%), Positives = 145/339 (42%), Gaps = 33/339 (9%)
Query: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
+TL LS N++ + + L L L L N + + FQ L +L+ L+L N+L
Sbjct: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160
Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRD 171
L A L + LDLSGN+L + L + LLG L L L N L L
Sbjct: 161 ---LPASLFTNLENLKLLDLSGNNL-THLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNS 216
Query: 172 MPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIE 231
+ AL +L H N + I GAF+ LP L+ L LSRN L + L L +++
Sbjct: 217 LGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPS-------ALFLHSHNLT 269
Query: 232 AFQTASQPQAE-----------FQLTWLDLRENKLLHFPDLAALPRLIYL--NLSNNLIR 278
P AE Q WL+ + + L L RL YL LS L
Sbjct: 270 LLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSA 329
Query: 279 LPTGPPQ---DSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFL 335
LP G Q + + + S G +ALP + R L +L + L N + +P +
Sbjct: 330 LPQGAFQGLGELQVLALHSNGLTALP------DGLLRGLGKLRQVSLRRNRLRALPRALF 383
Query: 336 EHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 374
+L+SL + L N L T G+LP L + L HN+
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
Score = 77.8 bits (190), Expect = 3e-14
Identities = 121/428 (28%), Positives = 176/428 (41%), Gaps = 71/428 (16%)
Query: 195 GLP-RLTHL---NLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDL 250
GLP LTH+ + R L S + L+ L +S + I A + +L L L
Sbjct: 47 GLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDL-IKLKTLRL 105
Query: 251 RENKLLHFPDLAALPRLIYLN---LSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSG 307
NK+ H P A L +++ L L +N +R G Q+
Sbjct: 106 SRNKITHLPG-ALLDKMVLLEQLFLDHNALR---GIDQNMF------------------- 142
Query: 308 NASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLML 367
+ L L L L+ N+++ +P S +L +L L+LS N L LG+ L
Sbjct: 143 ----QKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLER 198
Query: 368 LDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCG 426
L L N L +L+ G +LG+L L N +R + P F L +L L L N ++
Sbjct: 199 LLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLP 258
Query: 427 GP-------------------DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLH-T 466
+ PG V F + L+ L L ++ L A AF + +
Sbjct: 259 SALFLHSHNLTLLTLFENPLAELPG----VLFGEMGGLQELWLNRTQLRTLPAAAFRNLS 314
Query: 467 PLTELDLSSNPGLE-VATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAEN 524
L L ++ +P L + GA GL L+VLAL NGL L L + L++++L N
Sbjct: 315 RLRYLGVTLSPRLSALPQGAFQGL-GELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
Query: 525 RLSHLPA--WTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSC-CG---- 577
RL LP + SLE + L +N LPG G L L + L N C CG
Sbjct: 374 RLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGAL-PRLTEVLLGHNSWRCDCGLGPF 432
Query: 578 NGWLAAQL 585
GWL L
Sbjct: 433 LGWLRQHL 440
Score = 68.2 bits (165), Expect = 2e-11
Identities = 95/359 (26%), Positives = 141/359 (39%), Gaps = 46/359 (12%)
Query: 151 LHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLT 210
L L ++++ ++ + TF D+ L+ L L N + + + + L L L N+L
Sbjct: 76 LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALR 135
Query: 211 CISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALP 265
I Q+ L+ L L+ N ++ F AS L LDL N L H P L A
Sbjct: 136 GIDQNMFQKLVNLQELALNQNQLD-FLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQA 194
Query: 266 RLIYLNL-SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
+L L L SN L+ L +G + + + AP A R L L +L LS
Sbjct: 195 KLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAP--GAFDR-LPNLSSLTLSR 251
Query: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-- 382
N + +P + H +L L L N L G + L L L+ L TL A
Sbjct: 252 NHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFR 311
Query: 383 ------------------------RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQ 418
+ LG L+ L L N L LP L L++++L+
Sbjct: 312 NLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLR 371
Query: 419 GNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSN 476
NR+ F ++SL S+ L N++E L F P LTE+ L N
Sbjct: 372 RNRLRALPR---------ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 58.2 bits (139), Expect = 2e-08
Identities = 49/158 (31%), Positives = 70/158 (44%), Gaps = 3/158 (1%)
Query: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
L L N L + G L+ L L+ ++ L AF+ L+ L +L + + +
Sbjct: 271 LTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLS--PRLS 328
Query: 114 ALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMP 173
AL G L + L L N L + L + LL L +SL N L L R FR++
Sbjct: 329 ALPQGAFQGLGELQVLALHSNGL-TALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLS 387
Query: 174 ALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
+LE + L N L + F LPRLT + L NS C
Sbjct: 388 SLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRC 425
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 97.8 bits (242), Expect = 3e-20
Identities = 127/495 (25%), Positives = 194/495 (39%), Gaps = 86/495 (17%)
Query: 1 MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ 60
+RP++ LLL L A + C V C GL +P +P +TE L+L+GN
Sbjct: 14 VRPELWLLLWAAAWRLGASACPAL-CTCTGTTVDCHGTGLQAIPKNIPRNTERLELNGNN 72
Query: 61 LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL 120
+ I F L L L L N++ A+ G
Sbjct: 73 ITRI------------------------HKNDFAGLKQLRVLQLMENQIG---AVERGAF 105
Query: 121 GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL 180
+ + L L+ N L+ +L LL F++ AL +LDL
Sbjct: 106 DDMKELERLRLNRNQLH--MLPELL-----------------------FQNNQALSRLDL 140
Query: 181 HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLR---VLDLSCNSIEAFQTAS 237
N + I AF G L +L L +N ++CI + + + LR VL L+ N+I +S
Sbjct: 141 SENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSS 200
Query: 238 QPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGW 297
+L L N L LA L + + + L +G P +G++
Sbjct: 201 FNHMP-KLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSG-PASLRGLNVAEVQK 258
Query: 298 SALPLSAPSGNASGRPLSQLLN-------------LDLSYNEIELIPDSFLEHLTSLCFL 344
S S G A P L + +D + IP + E +T +
Sbjct: 259 SEFSCSG-QGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTE---I 314
Query: 345 NLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPP 403
L N +++ L +DLS+N + + A + L SL +L+L GN + DLP
Sbjct: 315 RLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPR 374
Query: 404 YTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF 463
F L +LQ L L N+++ C PD AF + +L LSL DN+I+ L G F
Sbjct: 375 GVFGGLYTLQLLLLNANKIN-CIRPD--------AFQDLQNLSLLSLYDNKIQSLAKGTF 425
Query: 464 LH-TPLTELDLSSNP 477
+ L L+ NP
Sbjct: 426 TSLRAIQTLHLAQNP 440
Score = 88.6 bits (218), Expect = 2e-17
Identities = 112/437 (25%), Positives = 181/437 (41%), Gaps = 60/437 (13%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEI 85
C + V C+ GL +P+ LP + L N ++SI Y LR +DLS N+I
Sbjct: 286 CTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQI 345
Query: 86 SFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLL 145
+ + P AFQ L L L L N++ LPR ++ GL
Sbjct: 346 AEIAPDAFQGLRSLNSLVLYGNKIT-----------DLPR---------GVFGGLY---- 381
Query: 146 GEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLS 205
+L L L N + + F+D+ L L L+ N + + G F L + L+L+
Sbjct: 382 ----TLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLA 437
Query: 206 RNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALP 265
+N C D +L+ L L N IE + ++ + +L + + K F A
Sbjct: 438 QNPFIC--DCNLKWLADF-LRTNPIET--SGARCASPRRLANKRIGQIKSKKFRCSAKEQ 492
Query: 266 RLI------YLNLS-NNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLL 318
I LN N+ + P ++ + S + +P P A
Sbjct: 493 YFIPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTA--------- 543
Query: 319 NLDLSYNEIELI-PDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALET 377
L L+ NEI ++ + LT L +NLS N + E + L L+ N LE+
Sbjct: 544 ELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES 603
Query: 378 LELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGC 436
+ G R L LRTL+L+ N + + +F L +++ L+L N+++ PG
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTV----SPG---- 655
Query: 437 VAFSGITSLRSLSLVDN 453
AF + SL +L+L+ N
Sbjct: 656 -AFDTLQSLSTLNLLAN 671
Score = 81.3 bits (199), Expect = 3e-15
Identities = 107/436 (24%), Positives = 171/436 (39%), Gaps = 90/436 (20%)
Query: 26 CKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHL---DLST 82
C+ V C L L ++P +P T L L+ N++ + A+ G + L HL +LS
Sbjct: 517 CRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEAT--GMFKKLTHLKKINLSN 574
Query: 83 NEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLE 142
N++S ++ GAF+ + L L N+L S+ SG+
Sbjct: 575 NKVSEIEDGAFEGAASVSELHLTANQL------------------------ESIRSGMFR 610
Query: 143 RLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
L G L TL L N ++ + +F + + L L+ N + + GAF+ L L+ L
Sbjct: 611 GLDG----LRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTL 666
Query: 203 NLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLD--LRENKLLHFPD 260
NL N +CN QL WL LR+ K++
Sbjct: 667 NLLANPF----------------NCNC--------------QLAWLGGWLRKRKIVTGNP 696
Query: 261 LAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNL 320
P + I L D + EG P A + + N
Sbjct: 697 RCQNPDFL------RQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSN- 749
Query: 321 DLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLEL 380
+ +P +++T L L N T +L + L L+DLS+N + +L
Sbjct: 750 ----KHLRALPKGIPKNVTELY---LDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSN 801
Query: 381 GARA-LGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAF 439
+ + L TL+L NAL+ +PP F L SL+ L+L GN +S + G F
Sbjct: 802 SSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTL----QEG-----IF 852
Query: 440 SGITSLRSLSLVDNEI 455
+ +TSL L++ N +
Sbjct: 853 ADVTSLSHLAIGANPL 868
Score = 68.6 bits (166), Expect = 2e-11
Identities = 108/430 (25%), Positives = 174/430 (40%), Gaps = 69/430 (16%)
Query: 62 RSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLG 121
+ + A P + + L N I + PGAF L + L++N++A + GL
Sbjct: 298 KGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR 357
Query: 122 PLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLH 181
SL++L L N +T L R F + L+ L L+
Sbjct: 358 ----------------------------SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLN 389
Query: 182 SNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ- 240
+N + I AF+ L L+ L+L N + ++ + LR +I+ A P
Sbjct: 390 ANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLR-------AIQTLHLAQNPFI 442
Query: 241 AEFQLTWLD--LRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSE--- 295
+ L WL LR N + A PR L+N I G + K + E
Sbjct: 443 CDCNLKWLADFLRTNPIETSGARCASPR----RLANKRI----GQIKSKKFRCSAKEQYF 494
Query: 296 --GWSALPLSAPSGNASGRPLS---QLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNC 350
G L++ + P + ++ S ++ IP+ + S L L+ N
Sbjct: 495 IPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQ---STAELRLNNNE 551
Query: 351 LRTFEARRL-GSLPCLMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFAN 408
+ EA + L L ++LS+N + +E GA S+ L L N L + F
Sbjct: 552 ISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRG 611
Query: 409 LASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAF-LHTP 467
L L+ L L+ NR+S C D +F+G+ ++R LSL DN+I + GAF
Sbjct: 612 LDGLRTLMLRNNRIS-CIHND--------SFTGLRNVRLLSLYDNQITTVSPGAFDTLQS 662
Query: 468 LTELDLSSNP 477
L+ L+L +NP
Sbjct: 663 LSTLNLLANP 672
Score = 68.2 bits (165), Expect = 2e-11
Identities = 125/467 (26%), Positives = 181/467 (38%), Gaps = 94/467 (20%)
Query: 178 LDLHSNVLMDIEDGAFEGLPRLTH-LNLSRNSLTCI--SDFS-LQQLRVLDLSCNSIEAF 233
+D H L I + +PR T L L+ N++T I +DF+ L+QLRVL L N I A
Sbjct: 45 VDCHGTGLQAIP----KNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAV 100
Query: 234 QTASQPQAEFQLTWLDLRENKLLHFPDLA-----ALPRLIYLNLSNNLIRLPTGPPQDSK 288
+ + + +L L L N+L P+L AL RL +LS N I+
Sbjct: 101 ERGAFDDMK-ELERLRLNRNQLHMLPELLFQNNQALSRL---DLSENAIQ---------- 146
Query: 289 GIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSR 348
A+P A G + L NL L N+I I + L L L L+
Sbjct: 147 ----------AIPRKAFRG------ATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNN 190
Query: 349 NCLRTFEARRLGSLPCLMLLDLSHNALE--------TLELGARALGSLRTLLLQGNALRD 400
N + T +P L L N L + L R L T +LR
Sbjct: 191 NNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRG 250
Query: 401 LPPYTFANLASLQRLNL------QGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVD-- 452
L N+A +Q+ + RV C P+ C +GI R L
Sbjct: 251 L------NVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP 304
Query: 453 --------------NEIELLRAGAFL-HTPLTELDLSSNPGLEVATGALGGLEASLEVLA 497
N I+ + GAF + L +DLS+N E+A A GL SL L
Sbjct: 305 ANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR-SLNSLV 363
Query: 498 LQGNGLMVLQVDLPCFI-----CLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFSL 550
L GN + DLP + L+ L L N+++ + A+ +L +L L +N
Sbjct: 364 LYGNKI----TDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQS 419
Query: 551 LPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQGRVDVDATQ 596
L L +++ L+L NP C C WLA L ++ +
Sbjct: 420 LAKGTFTSLR-AIQTLHLAQNPFICDCNLKWLADFLRTNPIETSGAR 465
Score = 50.4 bits (119), Expect = 5e-06
Identities = 64/218 (29%), Positives = 94/218 (43%), Gaps = 24/218 (11%)
Query: 380 LGARALGSL-----RTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
LGA A +L T+ G L+ +P N +RL L GN ++ D
Sbjct: 29 LGASACPALCTCTGTTVDCHGTGLQAIPKNIPRNT---ERLELNGNNITRIHKND----- 80
Query: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLEASL 493
F+G+ LR L L++N+I + GAF L L L+ N L + L +L
Sbjct: 81 ----FAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ-LHMLPELLFQNNQAL 135
Query: 494 EVLALQGNGLMVL-QVDLPCFICLKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSL 550
L L N + + + LK L L +N++S + A+ LEVL L NN+ +
Sbjct: 136 SRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITT 195
Query: 551 LPGSAMGGLETSLRRLYLQGNPLSC-CGNGWLAAQLHQ 587
+P S+ + LR L N L C C WL+ L Q
Sbjct: 196 IPVSSFNHM-PKLRTFRLHSNHLFCDCHLAWLSQWLRQ 232
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/97 (29%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 115 LSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPA 174
L G L + +DLS N + S L L TL L+ N+L + F+ + +
Sbjct: 775 LVPGQLSTFKYLQLVDLSNNKI-SSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRS 833
Query: 175 LEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTC 211
L L LH N + +++G F + L+HL + N L C
Sbjct: 834 LRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYC 870
Score = 36.6 bits (83), Expect = 0.076
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 3/86 (3%)
Query: 52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAM 111
+ +DLS N++ S+ S + L L LS N + + P AFQ L L LSL N +
Sbjct: 787 QLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDI-- 844
Query: 112 ATALSAGGLGPLPRVTSLDLSGNSLY 137
+ L G + ++ L + N LY
Sbjct: 845 -STLQEGIFADVTSLSHLAIGANPLY 869
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,558,479
Number of Sequences: 37866
Number of extensions: 1174838
Number of successful extensions: 7400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 3443
Number of HSP's gapped (non-prelim): 1668
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.