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Search of human proteins with 5031587
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
(2303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 4556 0.0
gi|189011568 adenomatous polyposis coli [Homo sapiens] 873 0.0
gi|189011566 adenomatous polyposis coli [Homo sapiens] 873 0.0
gi|53759122 adenomatous polyposis coli [Homo sapiens] 873 0.0
gi|163965366 nascent polypeptide-associated complex alpha subuni... 120 1e-26
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 114 1e-24
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 102 4e-21
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 97 2e-19
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 93 3e-18
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 92 6e-18
gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 89 7e-17
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 87 2e-16
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 87 2e-16
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 87 2e-16
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 87 2e-16
gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapi... 86 6e-16
gi|189181724 proteoglycan 4 isoform D [Homo sapiens] 82 5e-15
gi|189181722 proteoglycan 4 isoform C [Homo sapiens] 82 5e-15
gi|150170670 piccolo isoform 2 [Homo sapiens] 82 5e-15
gi|150378539 piccolo isoform 1 [Homo sapiens] 82 5e-15
gi|189181720 proteoglycan 4 isoform B [Homo sapiens] 80 2e-14
gi|67190163 proteoglycan 4 isoform A [Homo sapiens] 80 2e-14
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 80 2e-14
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 79 4e-14
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens] 77 3e-13
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 76 3e-13
gi|18079216 CASK interacting protein 1 [Homo sapiens] 75 6e-13
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens] 75 6e-13
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 74 2e-12
gi|145199237 transcription elongation factor B polypeptide 3 bin... 74 2e-12
>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
Length = 2303
Score = 4556 bits (11818), Expect = 0.0
Identities = 2303/2303 (100%), Positives = 2303/2303 (100%)
Query: 1 MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE 60
MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE
Sbjct: 1 MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQE 60
Query: 61 ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSF 120
ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSF
Sbjct: 61 ARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSF 120
Query: 121 GELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQM 180
GELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQM
Sbjct: 121 GELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQM 180
Query: 181 DLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA 240
DLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA
Sbjct: 181 DLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQA 240
Query: 241 LLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSS 300
LLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSS
Sbjct: 241 LLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSS 300
Query: 301 SPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPD 360
SPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPD
Sbjct: 301 SPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPD 360
Query: 361 QGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMK 420
QGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMK
Sbjct: 361 QGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMK 420
Query: 421 LSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVAN 480
LSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVAN
Sbjct: 421 LSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVAN 480
Query: 481 KATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQC 540
KATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQC
Sbjct: 481 KATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQC 540
Query: 541 VLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESG 600
VLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESG
Sbjct: 541 VLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESG 600
Query: 601 GGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQ 660
GGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQ
Sbjct: 601 GGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQ 660
Query: 661 ELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYV 720
ELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYV
Sbjct: 661 ELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYV 720
Query: 721 RKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDD 780
RKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDD
Sbjct: 721 RKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDD 780
Query: 781 DDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVA 840
DDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVA
Sbjct: 781 DDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVA 840
Query: 841 AKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG 900
AKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG
Sbjct: 841 AKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG 900
Query: 901 GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG 960
GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG
Sbjct: 901 GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCG 960
Query: 961 QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG 1020
QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG
Sbjct: 961 QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPG 1020
Query: 1021 ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAG 1080
ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAG
Sbjct: 1021 ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAG 1080
Query: 1081 RPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVE 1140
RPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVE
Sbjct: 1081 RPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVE 1140
Query: 1141 DATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPD 1200
DATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPD
Sbjct: 1141 DATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPD 1200
Query: 1201 SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS 1260
SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS
Sbjct: 1201 SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS 1260
Query: 1261 VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR 1320
VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR
Sbjct: 1261 VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR 1320
Query: 1321 REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP 1380
REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP
Sbjct: 1321 REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP 1380
Query: 1381 APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMG 1440
APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMG
Sbjct: 1381 APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMG 1440
Query: 1441 HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT 1500
HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT
Sbjct: 1441 HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT 1500
Query: 1501 PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP 1560
PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP
Sbjct: 1501 PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP 1560
Query: 1561 PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSP 1620
PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSP
Sbjct: 1561 PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSP 1620
Query: 1621 SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD 1680
SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD
Sbjct: 1621 SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD 1680
Query: 1681 LDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ 1740
LDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ
Sbjct: 1681 LDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ 1740
Query: 1741 AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPA 1800
AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPA
Sbjct: 1741 AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPA 1800
Query: 1801 PRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPR 1860
PRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPR
Sbjct: 1801 PRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPR 1860
Query: 1861 SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQ 1920
SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQ
Sbjct: 1861 SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQ 1920
Query: 1921 HKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS 1980
HKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS
Sbjct: 1921 HKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS 1980
Query: 1981 SGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCS 2040
SGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCS
Sbjct: 1981 SGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCS 2040
Query: 2041 SRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA 2100
SRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA
Sbjct: 2041 SRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA 2100
Query: 2101 SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRS 2160
SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRS
Sbjct: 2101 SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRS 2160
Query: 2161 TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG 2220
TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG
Sbjct: 2161 TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG 2220
Query: 2221 GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPM 2280
GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPM
Sbjct: 2221 GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPM 2280
Query: 2281 VVAATTDSAAEKAPATASATLLE 2303
VVAATTDSAAEKAPATASATLLE
Sbjct: 2281 VVAATTDSAAEKAPATASATLLE 2303
>gi|189011568 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 873 bits (2255), Expect = 0.0
Identities = 498/1007 (49%), Positives = 661/1007 (65%), Gaps = 93/1007 (9%)
Query: 4 SVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARV 63
+ A Y+QL++QVEALK ENS+LRQEL DNS+HL+KLETE S MKEVLK LQG +E EA
Sbjct: 2 AAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEA-- 59
Query: 64 LVSSGQTEVLEQLKALQMDITSLYNLKFQPP-------TLGPEPAARTPEGSPVHGSGPS 116
+ SSGQ ++LE+LK L +D ++ +K + + ++R+ E SPV
Sbjct: 60 MASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFP 119
Query: 117 KDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQF 176
+ F SR + LEEL++ER LL +++KEEKEK WYY+QLQ L+KR+D LP E F
Sbjct: 120 RRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEN-F 178
Query: 177 SMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLE-------- 228
S+Q D+ R+QLE+EA+ IR MEE+ GT +M +RAQ R +R++QI+K++L
Sbjct: 179 SLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQ 238
Query: 229 ---------------AQDRVQQTEPQALLAVK----------SVPVDEDPETEVPTHPED 263
+ D +Q E Q + + + +D + + + +
Sbjct: 239 ATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTH 298
Query: 264 GTPQPGNS----KVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQ 319
P+ S KVE+V+ LLSML T D++D +RTLLAMSSS +SC++MR+SGCLPLL+Q
Sbjct: 299 SAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQ 358
Query: 320 ILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRA 379
+LHG + + + G+K+AR RA+AALHNI+ SQPD R+E+RVLH+LEQIRA
Sbjct: 359 LLHGNDKDS---VLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRA 415
Query: 380 YCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQA 439
YCETCW+W +A + G + P P+E QIC A C +MKLSFDEE+R AMNELGGLQA
Sbjct: 416 YCETCWEWQEAHEPGMDQD-KNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQA 474
Query: 440 VAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLA 499
+AELLQVD EM+ +T D ++ LRRYAGM LTNLTFGDVANKATLC+ +GCM A+VAQL
Sbjct: 475 IAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK 534
Query: 500 SDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWN 559
S+SE+L QV++S+LRNLSWRAD+NSKK LRE GSV AL++C L KESTLKSVLSALWN
Sbjct: 535 SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWN 594
Query: 560 LSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQ 619
LSAH TENKA IC VDGAL FLV TLTY+ Q+N+LAIIESGGGILRNVSSL+AT ED+RQ
Sbjct: 595 LSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQ 654
Query: 620 VLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSK 679
+LR++NCLQTLLQHL SHSLTIVSNACGTLWNLSAR+ +DQE LWD+GAV ML+NL+HSK
Sbjct: 655 ILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK 714
Query: 680 HKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQAL 739
HKMIAMGSAAALRNL+A+RPAK++ A +SPGS +PSL+VRKQ+ALEAELDA+HL++
Sbjct: 715 HKMIAMGSAAALRNLMANRPAKYK-DANIMSPGSSLPSLHVRKQKALEAELDAQHLSETF 773
Query: 740 EHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASP 799
++++ P A+ + + RH L DY D+ DD+ + + TG
Sbjct: 774 DNIDNLSPKASHRSKQ------RHKQSLYGDYVFDTNRHDDNRSDN-----FNTG----- 817
Query: 800 AALSLFLGSPFLQGQALARTPPTRRG--GKEAEKDTSGE----------------AAVAA 841
++ + SP+L L + +R +EKD S E ++
Sbjct: 818 ---NMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSS 874
Query: 842 KAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG- 900
K +++ A+I +++E++SA+HTS +D S S+ + + S
Sbjct: 875 KRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNT 934
Query: 901 ---GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLP 944
+ E +R + K + SNDSLNS S+SDGY R M P
Sbjct: 935 YNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKP 981
Score = 210 bits (534), Expect = 1e-53
Identities = 168/463 (36%), Positives = 229/463 (49%), Gaps = 67/463 (14%)
Query: 1022 SPGARKQAWL---PADHLSKVPEKLAAAPLS-VASKALQKLAAQEGPLSLSRCSSLSSLS 1077
S A++Q L A S P+K A +S + + +Q ++ P+ SRCSSLSSLS
Sbjct: 1222 SSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLS 1281
Query: 1078 SA----GRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNR 1133
SA G ++ D ++ E E+ G AE D P + P + R +
Sbjct: 1282 SAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAE-DPVSEVPAVSQHPRTKSS--RLQ 1338
Query: 1134 GRGLGVEDA--------------------TPSSSSENYVQETPLVLSRCSSVSSLGSFES 1173
G L E A TP S E+YVQETPL+ SRC+SVSSL SFES
Sbjct: 1339 GSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFES 1398
Query: 1174 PSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQG-------PPEA 1226
SIASS+ SEPCSG SG ISPS+LPDSPGQTMPPSRSKTPP P PQ P
Sbjct: 1399 RSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP--PPPQTAQTKREVPKNK 1456
Query: 1227 TQFSLQWESYVKRFLDIADCRERCRLPSELDAGS-VRFTVEKPDENFSCASSLSALALHE 1285
+ + ES K+ A + LP DA + + F E + FSC+SSLSAL+L E
Sbjct: 1457 APTAEKRESGPKQAAVNAAVQRVQVLP---DADTLLHFATESTPDGFSCSSSLSALSLDE 1513
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPR----GAADQELE 1341
++Q+DVELR++P G + + +E+ T + + D ++E
Sbjct: 1514 PFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIE 1573
Query: 1342 LLRECLGAAVPARLRK-------VASALVP--GRRALPVPVYMLVPAPAPAQ-------- 1384
+L EC+ +A+P + + AS L P R+ +PVY L+P+ Q
Sbjct: 1574 ILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFT 1633
Query: 1385 --EDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGR 1425
+D EGTP+NFS+A SLSD T++ PP + G R
Sbjct: 1634 PGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVR 1676
Score = 188 bits (477), Expect = 6e-47
Identities = 273/998 (27%), Positives = 410/998 (41%), Gaps = 208/998 (20%)
Query: 1478 DKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS----------------------- 1514
DK + R RG A S TP E YCF NDS
Sbjct: 1825 DKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKA 1884
Query: 1515 DEEPPAAAPTPTH----------RRTSAIPRA-FTRERPQG--RKEAPAPSKAAPAAPPP 1561
E + A +H +T AI + R +P+ +K++ P +
Sbjct: 1885 KENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRG 1944
Query: 1562 ARTQPSL---IADETPPCYSLSSSASSLS---------EPEP---SEPPAVHPRGREPAV 1606
A T L + TP C+S +SS SSLS E EP +EPP +P
Sbjct: 1945 AATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQA 2004
Query: 1607 T---------KDPGPGGGRDSSPSPRAAE---ELLQRCISSALPRRRPPVSGLR----RR 1650
+ +D R+SS S + + +LLQ CISSA+P+++ P S L+ +
Sbjct: 2005 SGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKP-SRLKGDNEKH 2063
Query: 1651 KPRATR--LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAA-- 1706
PR L E ++ + + D ++ +W+AIQEGANSIV+ LHQAAAA
Sbjct: 2064 SPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAC 2123
Query: 1707 -TREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRP------EKRGAASV 1759
+R+ASS+SDSILS SG+S+GS P H Q E S + P EK +
Sbjct: 2124 LSRQASSDSDSILSLKSGISLGS----PFHLTPDQEEKPFTSNKGPRILKPGEKSTLETK 2179
Query: 1760 KTSGSPRSPAGPEK-----------------PRGTQKTTPGVPAVLRGRTVIYVPSPAPR 1802
K + G +K + Q +P++ RGRT+I++P
Sbjct: 2180 KIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPG---- 2235
Query: 1803 AQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSA 1862
+ + + K PP L PA +K PS GQ + S R AK S + LS R
Sbjct: 2236 --VRNSSSSTSPVSKKGPP-LKTPA--SKSPSEGQTATTS-PRGAKPSVKSELSPVARQT 2289
Query: 1863 TPPARLAKTPSSSSSQTS----PASQPLPRK-----RPPVTQAAGALPGPG-ASPVPKTP 1912
+ +K PS S S+ S PA QPL R R ++ + P S +P+T
Sbjct: 2290 SQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTS 2349
Query: 1913 ARTLLAKQHK-----TQRSPVRIPFMQRPARR-GPPPLARAVP--EPGPRGRAGTEAGPG 1964
+ + + + + SP R Q ++ G A ++P E +G G G
Sbjct: 2350 SPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNG 2409
Query: 1965 ARGGRLGLVRVASALSSGSES--SDRSGFRRQLTFIKE--SPGLRRRRSELSSAESAASA 2020
A ++ L R++S SSGSES S+R RQ TFIKE SP LRR+ E +S ES + +
Sbjct: 2410 A-NKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPS 2468
Query: 2021 PQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPA--RQRPPAARPS---PGERPAR- 2074
+ ASP R + P + S ++ + R+ PP P+ RPA+
Sbjct: 2469 SRPASPTRSQAQTPVL---SPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKR 2525
Query: 2075 ----RTTSESPSRLPV-RAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSS 2129
R+ SESPSRLP+ R+ + E K +SLP +S RR + AS++++ ++
Sbjct: 2526 HDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAK 2585
Query: 2130 DGEPRPL-----------PRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDA- 2177
+ + + +V+A G TWR+I++ + ++ ++ G+ +
Sbjct: 2586 SEDEKHVNSISGTKQSKENQVSAKG-TWRKIKENEFSPTNSTSQTVSSGATNGAESKTLI 2644
Query: 2178 -PAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLA 2236
P KT D V+ E+ S SP+ T PP + + + + A
Sbjct: 2645 YQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNT--PPVIDSVSEKANPNIKDSKDNQA 2702
Query: 2237 KAPI---SAPFVHEGLGVAVGGF------------------------------------- 2256
K + S P GL + F
Sbjct: 2703 KQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPF 2762
Query: 2257 ---PASRHGSPSR--SARVPPFNYVPSPMVVAATTDSA 2289
+S+H SPS +ARV PFNY PSP +A + SA
Sbjct: 2763 SSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA 2800
Score = 36.2 bits (82), Expect = 0.38
Identities = 44/176 (25%), Positives = 62/176 (35%), Gaps = 48/176 (27%)
Query: 1518 PPAAAPTP-----THRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAP-------PPARTQ 1565
PP+ + TP T + +P+ + P K P +AA A P A T
Sbjct: 1432 PPSRSKTPPPPPQTAQTKREVPK---NKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTL 1488
Query: 1566 PSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAA 1625
+ TP +S SSS S+LS EP V R P D G S P+ +
Sbjct: 1489 LHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQEND---NGNETESEQPKES 1545
Query: 1626 E--------------------------ELLQRCISSALPRRRPPVSGLRRRKPRAT 1655
E+L+ CI SA+P + S + +KP T
Sbjct: 1546 NENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTK----SSRKAKKPAQT 1597
Score = 35.4 bits (80), Expect = 0.65
Identities = 55/244 (22%), Positives = 90/244 (36%), Gaps = 44/244 (18%)
Query: 854 IDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLL 913
ID ++ + + +S SFS S GQ + E + S P + ++ HP
Sbjct: 1177 IDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQ-NQLHPSS 1235
Query: 914 R-------LKAAHASLSNDSLNSGSASDGYCPREHML----PCPLAALASRREDPRCGQP 962
KAA +S S+N + YC + + L++L+S ++ C Q
Sbjct: 1236 AQSRSGQPQKAATCKVS--SINQETIQT-YCVEDTPICFSRCSSLSSLSSAEDEIGCNQ- 1291
Query: 963 RPSRLDLDLPGCQAEPPAREATSADA--------RVRTIKLSPTYQHVPLLEGASRAGAE 1014
+EA SA+ ++ T VP + R +
Sbjct: 1292 ----------------TTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSS 1335
Query: 1015 PLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLS 1074
L G +S + + + +K P K A K+ + QE PL SRC+S+S
Sbjct: 1336 RLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ----TPKSPPEHYVQETPLMFSRCTSVS 1391
Query: 1075 SLSS 1078
SL S
Sbjct: 1392 SLDS 1395
Score = 34.7 bits (78), Expect = 1.1
Identities = 49/203 (24%), Positives = 87/203 (42%), Gaps = 45/203 (22%)
Query: 968 DLDLPGCQAE-PPAREATSADARVRT-IKLSPTYQHVPLLEGASRAGAEPLAGPGISPGA 1025
D+DL +AE A+E ++A+V + +L+ Q + ++ +P+ P
Sbjct: 1871 DVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAK---QPINRGQPKPIL 1927
Query: 1026 RKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPS 1085
+KQ+ P +P++ AA + LQ A + P+ S SSLSSLS
Sbjct: 1928 QKQSTFPQSS-KDIPDRGAAT-----DEKLQNFAIENTPVCFSHNSSLSSLSDI------ 1975
Query: 1086 EGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPS 1145
D ++++ E ++E P +++ G S P A+
Sbjct: 1976 ---DQENNNKENEPIKETEPPDSQ--------GEPSKP-----------------QASGY 2007
Query: 1146 SSSENYVQETPLVLSRCSSVSSL 1168
+ +V++TP+ SR SS+SSL
Sbjct: 2008 APKSFHVEDTPVCFSRNSSLSSL 2030
>gi|189011566 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 873 bits (2255), Expect = 0.0
Identities = 498/1007 (49%), Positives = 661/1007 (65%), Gaps = 93/1007 (9%)
Query: 4 SVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARV 63
+ A Y+QL++QVEALK ENS+LRQEL DNS+HL+KLETE S MKEVLK LQG +E EA
Sbjct: 2 AAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEA-- 59
Query: 64 LVSSGQTEVLEQLKALQMDITSLYNLKFQPP-------TLGPEPAARTPEGSPVHGSGPS 116
+ SSGQ ++LE+LK L +D ++ +K + + ++R+ E SPV
Sbjct: 60 MASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFP 119
Query: 117 KDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQF 176
+ F SR + LEEL++ER LL +++KEEKEK WYY+QLQ L+KR+D LP E F
Sbjct: 120 RRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEN-F 178
Query: 177 SMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLE-------- 228
S+Q D+ R+QLE+EA+ IR MEE+ GT +M +RAQ R +R++QI+K++L
Sbjct: 179 SLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQ 238
Query: 229 ---------------AQDRVQQTEPQALLAVK----------SVPVDEDPETEVPTHPED 263
+ D +Q E Q + + + +D + + + +
Sbjct: 239 ATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTH 298
Query: 264 GTPQPGNS----KVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQ 319
P+ S KVE+V+ LLSML T D++D +RTLLAMSSS +SC++MR+SGCLPLL+Q
Sbjct: 299 SAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQ 358
Query: 320 ILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRA 379
+LHG + + + G+K+AR RA+AALHNI+ SQPD R+E+RVLH+LEQIRA
Sbjct: 359 LLHGNDKDS---VLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRA 415
Query: 380 YCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQA 439
YCETCW+W +A + G + P P+E QIC A C +MKLSFDEE+R AMNELGGLQA
Sbjct: 416 YCETCWEWQEAHEPGMDQD-KNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQA 474
Query: 440 VAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLA 499
+AELLQVD EM+ +T D ++ LRRYAGM LTNLTFGDVANKATLC+ +GCM A+VAQL
Sbjct: 475 IAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK 534
Query: 500 SDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWN 559
S+SE+L QV++S+LRNLSWRAD+NSKK LRE GSV AL++C L KESTLKSVLSALWN
Sbjct: 535 SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWN 594
Query: 560 LSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQ 619
LSAH TENKA IC VDGAL FLV TLTY+ Q+N+LAIIESGGGILRNVSSL+AT ED+RQ
Sbjct: 595 LSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQ 654
Query: 620 VLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSK 679
+LR++NCLQTLLQHL SHSLTIVSNACGTLWNLSAR+ +DQE LWD+GAV ML+NL+HSK
Sbjct: 655 ILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK 714
Query: 680 HKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQAL 739
HKMIAMGSAAALRNL+A+RPAK++ A +SPGS +PSL+VRKQ+ALEAELDA+HL++
Sbjct: 715 HKMIAMGSAAALRNLMANRPAKYK-DANIMSPGSSLPSLHVRKQKALEAELDAQHLSETF 773
Query: 740 EHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASP 799
++++ P A+ + + RH L DY D+ DD+ + + TG
Sbjct: 774 DNIDNLSPKASHRSKQ------RHKQSLYGDYVFDTNRHDDNRSDN-----FNTG----- 817
Query: 800 AALSLFLGSPFLQGQALARTPPTRRG--GKEAEKDTSGE----------------AAVAA 841
++ + SP+L L + +R +EKD S E ++
Sbjct: 818 ---NMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSS 874
Query: 842 KAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG- 900
K +++ A+I +++E++SA+HTS +D S S+ + + S
Sbjct: 875 KRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNT 934
Query: 901 ---GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLP 944
+ E +R + K + SNDSLNS S+SDGY R M P
Sbjct: 935 YNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKP 981
Score = 210 bits (534), Expect = 1e-53
Identities = 168/463 (36%), Positives = 229/463 (49%), Gaps = 67/463 (14%)
Query: 1022 SPGARKQAWL---PADHLSKVPEKLAAAPLS-VASKALQKLAAQEGPLSLSRCSSLSSLS 1077
S A++Q L A S P+K A +S + + +Q ++ P+ SRCSSLSSLS
Sbjct: 1222 SSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLS 1281
Query: 1078 SA----GRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNR 1133
SA G ++ D ++ E E+ G AE D P + P + R +
Sbjct: 1282 SAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAE-DPVSEVPAVSQHPRTKSS--RLQ 1338
Query: 1134 GRGLGVEDA--------------------TPSSSSENYVQETPLVLSRCSSVSSLGSFES 1173
G L E A TP S E+YVQETPL+ SRC+SVSSL SFES
Sbjct: 1339 GSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFES 1398
Query: 1174 PSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQG-------PPEA 1226
SIASS+ SEPCSG SG ISPS+LPDSPGQTMPPSRSKTPP P PQ P
Sbjct: 1399 RSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP--PPPQTAQTKREVPKNK 1456
Query: 1227 TQFSLQWESYVKRFLDIADCRERCRLPSELDAGS-VRFTVEKPDENFSCASSLSALALHE 1285
+ + ES K+ A + LP DA + + F E + FSC+SSLSAL+L E
Sbjct: 1457 APTAEKRESGPKQAAVNAAVQRVQVLP---DADTLLHFATESTPDGFSCSSSLSALSLDE 1513
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPR----GAADQELE 1341
++Q+DVELR++P G + + +E+ T + + D ++E
Sbjct: 1514 PFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIE 1573
Query: 1342 LLRECLGAAVPARLRK-------VASALVP--GRRALPVPVYMLVPAPAPAQ-------- 1384
+L EC+ +A+P + + AS L P R+ +PVY L+P+ Q
Sbjct: 1574 ILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFT 1633
Query: 1385 --EDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGR 1425
+D EGTP+NFS+A SLSD T++ PP + G R
Sbjct: 1634 PGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVR 1676
Score = 188 bits (477), Expect = 6e-47
Identities = 273/998 (27%), Positives = 410/998 (41%), Gaps = 208/998 (20%)
Query: 1478 DKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS----------------------- 1514
DK + R RG A S TP E YCF NDS
Sbjct: 1825 DKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKA 1884
Query: 1515 DEEPPAAAPTPTH----------RRTSAIPRA-FTRERPQG--RKEAPAPSKAAPAAPPP 1561
E + A +H +T AI + R +P+ +K++ P +
Sbjct: 1885 KENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRG 1944
Query: 1562 ARTQPSL---IADETPPCYSLSSSASSLS---------EPEP---SEPPAVHPRGREPAV 1606
A T L + TP C+S +SS SSLS E EP +EPP +P
Sbjct: 1945 AATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQA 2004
Query: 1607 T---------KDPGPGGGRDSSPSPRAAE---ELLQRCISSALPRRRPPVSGLR----RR 1650
+ +D R+SS S + + +LLQ CISSA+P+++ P S L+ +
Sbjct: 2005 SGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKP-SRLKGDNEKH 2063
Query: 1651 KPRATR--LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAA-- 1706
PR L E ++ + + D ++ +W+AIQEGANSIV+ LHQAAAA
Sbjct: 2064 SPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAC 2123
Query: 1707 -TREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRP------EKRGAASV 1759
+R+ASS+SDSILS SG+S+GS P H Q E S + P EK +
Sbjct: 2124 LSRQASSDSDSILSLKSGISLGS----PFHLTPDQEEKPFTSNKGPRILKPGEKSTLETK 2179
Query: 1760 KTSGSPRSPAGPEK-----------------PRGTQKTTPGVPAVLRGRTVIYVPSPAPR 1802
K + G +K + Q +P++ RGRT+I++P
Sbjct: 2180 KIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPG---- 2235
Query: 1803 AQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSA 1862
+ + + K PP L PA +K PS GQ + S R AK S + LS R
Sbjct: 2236 --VRNSSSSTSPVSKKGPP-LKTPA--SKSPSEGQTATTS-PRGAKPSVKSELSPVARQT 2289
Query: 1863 TPPARLAKTPSSSSSQTS----PASQPLPRK-----RPPVTQAAGALPGPG-ASPVPKTP 1912
+ +K PS S S+ S PA QPL R R ++ + P S +P+T
Sbjct: 2290 SQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTS 2349
Query: 1913 ARTLLAKQHK-----TQRSPVRIPFMQRPARR-GPPPLARAVP--EPGPRGRAGTEAGPG 1964
+ + + + + SP R Q ++ G A ++P E +G G G
Sbjct: 2350 SPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNG 2409
Query: 1965 ARGGRLGLVRVASALSSGSES--SDRSGFRRQLTFIKE--SPGLRRRRSELSSAESAASA 2020
A ++ L R++S SSGSES S+R RQ TFIKE SP LRR+ E +S ES + +
Sbjct: 2410 A-NKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPS 2468
Query: 2021 PQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPA--RQRPPAARPS---PGERPAR- 2074
+ ASP R + P + S ++ + R+ PP P+ RPA+
Sbjct: 2469 SRPASPTRSQAQTPVL---SPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKR 2525
Query: 2075 ----RTTSESPSRLPV-RAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSS 2129
R+ SESPSRLP+ R+ + E K +SLP +S RR + AS++++ ++
Sbjct: 2526 HDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAK 2585
Query: 2130 DGEPRPL-----------PRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDA- 2177
+ + + +V+A G TWR+I++ + ++ ++ G+ +
Sbjct: 2586 SEDEKHVNSISGTKQSKENQVSAKG-TWRKIKENEFSPTNSTSQTVSSGATNGAESKTLI 2644
Query: 2178 -PAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLA 2236
P KT D V+ E+ S SP+ T PP + + + + A
Sbjct: 2645 YQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNT--PPVIDSVSEKANPNIKDSKDNQA 2702
Query: 2237 KAPI---SAPFVHEGLGVAVGGF------------------------------------- 2256
K + S P GL + F
Sbjct: 2703 KQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPF 2762
Query: 2257 ---PASRHGSPSR--SARVPPFNYVPSPMVVAATTDSA 2289
+S+H SPS +ARV PFNY PSP +A + SA
Sbjct: 2763 SSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA 2800
Score = 36.2 bits (82), Expect = 0.38
Identities = 44/176 (25%), Positives = 62/176 (35%), Gaps = 48/176 (27%)
Query: 1518 PPAAAPTP-----THRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAP-------PPARTQ 1565
PP+ + TP T + +P+ + P K P +AA A P A T
Sbjct: 1432 PPSRSKTPPPPPQTAQTKREVPK---NKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTL 1488
Query: 1566 PSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAA 1625
+ TP +S SSS S+LS EP V R P D G S P+ +
Sbjct: 1489 LHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQEND---NGNETESEQPKES 1545
Query: 1626 E--------------------------ELLQRCISSALPRRRPPVSGLRRRKPRAT 1655
E+L+ CI SA+P + S + +KP T
Sbjct: 1546 NENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTK----SSRKAKKPAQT 1597
Score = 35.4 bits (80), Expect = 0.65
Identities = 55/244 (22%), Positives = 90/244 (36%), Gaps = 44/244 (18%)
Query: 854 IDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLL 913
ID ++ + + +S SFS S GQ + E + S P + ++ HP
Sbjct: 1177 IDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQ-NQLHPSS 1235
Query: 914 R-------LKAAHASLSNDSLNSGSASDGYCPREHML----PCPLAALASRREDPRCGQP 962
KAA +S S+N + YC + + L++L+S ++ C Q
Sbjct: 1236 AQSRSGQPQKAATCKVS--SINQETIQT-YCVEDTPICFSRCSSLSSLSSAEDEIGCNQ- 1291
Query: 963 RPSRLDLDLPGCQAEPPAREATSADA--------RVRTIKLSPTYQHVPLLEGASRAGAE 1014
+EA SA+ ++ T VP + R +
Sbjct: 1292 ----------------TTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSS 1335
Query: 1015 PLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLS 1074
L G +S + + + +K P K A K+ + QE PL SRC+S+S
Sbjct: 1336 RLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ----TPKSPPEHYVQETPLMFSRCTSVS 1391
Query: 1075 SLSS 1078
SL S
Sbjct: 1392 SLDS 1395
Score = 34.7 bits (78), Expect = 1.1
Identities = 49/203 (24%), Positives = 87/203 (42%), Gaps = 45/203 (22%)
Query: 968 DLDLPGCQAE-PPAREATSADARVRT-IKLSPTYQHVPLLEGASRAGAEPLAGPGISPGA 1025
D+DL +AE A+E ++A+V + +L+ Q + ++ +P+ P
Sbjct: 1871 DVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAK---QPINRGQPKPIL 1927
Query: 1026 RKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPS 1085
+KQ+ P +P++ AA + LQ A + P+ S SSLSSLS
Sbjct: 1928 QKQSTFPQSS-KDIPDRGAAT-----DEKLQNFAIENTPVCFSHNSSLSSLSDI------ 1975
Query: 1086 EGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPS 1145
D ++++ E ++E P +++ G S P A+
Sbjct: 1976 ---DQENNNKENEPIKETEPPDSQ--------GEPSKP-----------------QASGY 2007
Query: 1146 SSSENYVQETPLVLSRCSSVSSL 1168
+ +V++TP+ SR SS+SSL
Sbjct: 2008 APKSFHVEDTPVCFSRNSSLSSL 2030
>gi|53759122 adenomatous polyposis coli [Homo sapiens]
Length = 2843
Score = 873 bits (2255), Expect = 0.0
Identities = 498/1007 (49%), Positives = 661/1007 (65%), Gaps = 93/1007 (9%)
Query: 4 SVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARV 63
+ A Y+QL++QVEALK ENS+LRQEL DNS+HL+KLETE S MKEVLK LQG +E EA
Sbjct: 2 AAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEA-- 59
Query: 64 LVSSGQTEVLEQLKALQMDITSLYNLKFQPP-------TLGPEPAARTPEGSPVHGSGPS 116
+ SSGQ ++LE+LK L +D ++ +K + + ++R+ E SPV
Sbjct: 60 MASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFP 119
Query: 117 KDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQF 176
+ F SR + LEEL++ER LL +++KEEKEK WYY+QLQ L+KR+D LP E F
Sbjct: 120 RRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTEN-F 178
Query: 177 SMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLE-------- 228
S+Q D+ R+QLE+EA+ IR MEE+ GT +M +RAQ R +R++QI+K++L
Sbjct: 179 SLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQ 238
Query: 229 ---------------AQDRVQQTEPQALLAVK----------SVPVDEDPETEVPTHPED 263
+ D +Q E Q + + + +D + + + +
Sbjct: 239 ATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTH 298
Query: 264 GTPQPGNS----KVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQ 319
P+ S KVE+V+ LLSML T D++D +RTLLAMSSS +SC++MR+SGCLPLL+Q
Sbjct: 299 SAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQ 358
Query: 320 ILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRA 379
+LHG + + + G+K+AR RA+AALHNI+ SQPD R+E+RVLH+LEQIRA
Sbjct: 359 LLHGNDKDS---VLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRA 415
Query: 380 YCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQA 439
YCETCW+W +A + G + P P+E QIC A C +MKLSFDEE+R AMNELGGLQA
Sbjct: 416 YCETCWEWQEAHEPGMDQD-KNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQA 474
Query: 440 VAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLA 499
+AELLQVD EM+ +T D ++ LRRYAGM LTNLTFGDVANKATLC+ +GCM A+VAQL
Sbjct: 475 IAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLK 534
Query: 500 SDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWN 559
S+SE+L QV++S+LRNLSWRAD+NSKK LRE GSV AL++C L KESTLKSVLSALWN
Sbjct: 535 SESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWN 594
Query: 560 LSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQ 619
LSAH TENKA IC VDGAL FLV TLTY+ Q+N+LAIIESGGGILRNVSSL+AT ED+RQ
Sbjct: 595 LSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQ 654
Query: 620 VLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSK 679
+LR++NCLQTLLQHL SHSLTIVSNACGTLWNLSAR+ +DQE LWD+GAV ML+NL+HSK
Sbjct: 655 ILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK 714
Query: 680 HKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQAL 739
HKMIAMGSAAALRNL+A+RPAK++ A +SPGS +PSL+VRKQ+ALEAELDA+HL++
Sbjct: 715 HKMIAMGSAAALRNLMANRPAKYK-DANIMSPGSSLPSLHVRKQKALEAELDAQHLSETF 773
Query: 740 EHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASP 799
++++ P A+ + + RH L DY D+ DD+ + + TG
Sbjct: 774 DNIDNLSPKASHRSKQ------RHKQSLYGDYVFDTNRHDDNRSDN-----FNTG----- 817
Query: 800 AALSLFLGSPFLQGQALARTPPTRRG--GKEAEKDTSGE----------------AAVAA 841
++ + SP+L L + +R +EKD S E ++
Sbjct: 818 ---NMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSS 874
Query: 842 KAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEG- 900
K +++ A+I +++E++SA+HTS +D S S+ + + S
Sbjct: 875 KRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNT 934
Query: 901 ---GRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLP 944
+ E +R + K + SNDSLNS S+SDGY R M P
Sbjct: 935 YNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKP 981
Score = 210 bits (534), Expect = 1e-53
Identities = 168/463 (36%), Positives = 229/463 (49%), Gaps = 67/463 (14%)
Query: 1022 SPGARKQAWL---PADHLSKVPEKLAAAPLS-VASKALQKLAAQEGPLSLSRCSSLSSLS 1077
S A++Q L A S P+K A +S + + +Q ++ P+ SRCSSLSSLS
Sbjct: 1222 SSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLS 1281
Query: 1078 SA----GRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNR 1133
SA G ++ D ++ E E+ G AE D P + P + R +
Sbjct: 1282 SAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAE-DPVSEVPAVSQHPRTKSS--RLQ 1338
Query: 1134 GRGLGVEDA--------------------TPSSSSENYVQETPLVLSRCSSVSSLGSFES 1173
G L E A TP S E+YVQETPL+ SRC+SVSSL SFES
Sbjct: 1339 GSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFES 1398
Query: 1174 PSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQG-------PPEA 1226
SIASS+ SEPCSG SG ISPS+LPDSPGQTMPPSRSKTPP P PQ P
Sbjct: 1399 RSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP--PPPQTAQTKREVPKNK 1456
Query: 1227 TQFSLQWESYVKRFLDIADCRERCRLPSELDAGS-VRFTVEKPDENFSCASSLSALALHE 1285
+ + ES K+ A + LP DA + + F E + FSC+SSLSAL+L E
Sbjct: 1457 APTAEKRESGPKQAAVNAAVQRVQVLP---DADTLLHFATESTPDGFSCSSSLSALSLDE 1513
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPR----GAADQELE 1341
++Q+DVELR++P G + + +E+ T + + D ++E
Sbjct: 1514 PFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIE 1573
Query: 1342 LLRECLGAAVPARLRK-------VASALVP--GRRALPVPVYMLVPAPAPAQ-------- 1384
+L EC+ +A+P + + AS L P R+ +PVY L+P+ Q
Sbjct: 1574 ILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFT 1633
Query: 1385 --EDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGR 1425
+D EGTP+NFS+A SLSD T++ PP + G R
Sbjct: 1634 PGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVR 1676
Score = 188 bits (477), Expect = 6e-47
Identities = 273/998 (27%), Positives = 410/998 (41%), Gaps = 208/998 (20%)
Query: 1478 DKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS----------------------- 1514
DK + R RG A S TP E YCF NDS
Sbjct: 1825 DKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKA 1884
Query: 1515 DEEPPAAAPTPTH----------RRTSAIPRA-FTRERPQG--RKEAPAPSKAAPAAPPP 1561
E + A +H +T AI + R +P+ +K++ P +
Sbjct: 1885 KENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRG 1944
Query: 1562 ARTQPSL---IADETPPCYSLSSSASSLS---------EPEP---SEPPAVHPRGREPAV 1606
A T L + TP C+S +SS SSLS E EP +EPP +P
Sbjct: 1945 AATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQA 2004
Query: 1607 T---------KDPGPGGGRDSSPSPRAAE---ELLQRCISSALPRRRPPVSGLR----RR 1650
+ +D R+SS S + + +LLQ CISSA+P+++ P S L+ +
Sbjct: 2005 SGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKP-SRLKGDNEKH 2063
Query: 1651 KPRATR--LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAA-- 1706
PR L E ++ + + D ++ +W+AIQEGANSIV+ LHQAAAA
Sbjct: 2064 SPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAC 2123
Query: 1707 -TREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRP------EKRGAASV 1759
+R+ASS+SDSILS SG+S+GS P H Q E S + P EK +
Sbjct: 2124 LSRQASSDSDSILSLKSGISLGS----PFHLTPDQEEKPFTSNKGPRILKPGEKSTLETK 2179
Query: 1760 KTSGSPRSPAGPEK-----------------PRGTQKTTPGVPAVLRGRTVIYVPSPAPR 1802
K + G +K + Q +P++ RGRT+I++P
Sbjct: 2180 KIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPG---- 2235
Query: 1803 AQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSA 1862
+ + + K PP L PA +K PS GQ + S R AK S + LS R
Sbjct: 2236 --VRNSSSSTSPVSKKGPP-LKTPA--SKSPSEGQTATTS-PRGAKPSVKSELSPVARQT 2289
Query: 1863 TPPARLAKTPSSSSSQTS----PASQPLPRK-----RPPVTQAAGALPGPG-ASPVPKTP 1912
+ +K PS S S+ S PA QPL R R ++ + P S +P+T
Sbjct: 2290 SQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTS 2349
Query: 1913 ARTLLAKQHK-----TQRSPVRIPFMQRPARR-GPPPLARAVP--EPGPRGRAGTEAGPG 1964
+ + + + + SP R Q ++ G A ++P E +G G G
Sbjct: 2350 SPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNG 2409
Query: 1965 ARGGRLGLVRVASALSSGSES--SDRSGFRRQLTFIKE--SPGLRRRRSELSSAESAASA 2020
A ++ L R++S SSGSES S+R RQ TFIKE SP LRR+ E +S ES + +
Sbjct: 2410 A-NKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPS 2468
Query: 2021 PQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPA--RQRPPAARPS---PGERPAR- 2074
+ ASP R + P + S ++ + R+ PP P+ RPA+
Sbjct: 2469 SRPASPTRSQAQTPVL---SPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKR 2525
Query: 2075 ----RTTSESPSRLPV-RAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSS 2129
R+ SESPSRLP+ R+ + E K +SLP +S RR + AS++++ ++
Sbjct: 2526 HDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAK 2585
Query: 2130 DGEPRPL-----------PRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDA- 2177
+ + + +V+A G TWR+I++ + ++ ++ G+ +
Sbjct: 2586 SEDEKHVNSISGTKQSKENQVSAKG-TWRKIKENEFSPTNSTSQTVSSGATNGAESKTLI 2644
Query: 2178 -PAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLA 2236
P KT D V+ E+ S SP+ T PP + + + + A
Sbjct: 2645 YQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNT--PPVIDSVSEKANPNIKDSKDNQA 2702
Query: 2237 KAPI---SAPFVHEGLGVAVGGF------------------------------------- 2256
K + S P GL + F
Sbjct: 2703 KQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPF 2762
Query: 2257 ---PASRHGSPSR--SARVPPFNYVPSPMVVAATTDSA 2289
+S+H SPS +ARV PFNY PSP +A + SA
Sbjct: 2763 SSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSA 2800
Score = 36.2 bits (82), Expect = 0.38
Identities = 44/176 (25%), Positives = 62/176 (35%), Gaps = 48/176 (27%)
Query: 1518 PPAAAPTP-----THRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAP-------PPARTQ 1565
PP+ + TP T + +P+ + P K P +AA A P A T
Sbjct: 1432 PPSRSKTPPPPPQTAQTKREVPK---NKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTL 1488
Query: 1566 PSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAA 1625
+ TP +S SSS S+LS EP V R P D G S P+ +
Sbjct: 1489 LHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQEND---NGNETESEQPKES 1545
Query: 1626 E--------------------------ELLQRCISSALPRRRPPVSGLRRRKPRAT 1655
E+L+ CI SA+P + S + +KP T
Sbjct: 1546 NENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTK----SSRKAKKPAQT 1597
Score = 35.4 bits (80), Expect = 0.65
Identities = 55/244 (22%), Positives = 90/244 (36%), Gaps = 44/244 (18%)
Query: 854 IDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLL 913
ID ++ + + +S SFS S GQ + E + S P + ++ HP
Sbjct: 1177 IDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQ-NQLHPSS 1235
Query: 914 R-------LKAAHASLSNDSLNSGSASDGYCPREHML----PCPLAALASRREDPRCGQP 962
KAA +S S+N + YC + + L++L+S ++ C Q
Sbjct: 1236 AQSRSGQPQKAATCKVS--SINQETIQT-YCVEDTPICFSRCSSLSSLSSAEDEIGCNQ- 1291
Query: 963 RPSRLDLDLPGCQAEPPAREATSADA--------RVRTIKLSPTYQHVPLLEGASRAGAE 1014
+EA SA+ ++ T VP + R +
Sbjct: 1292 ----------------TTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSS 1335
Query: 1015 PLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLS 1074
L G +S + + + +K P K A K+ + QE PL SRC+S+S
Sbjct: 1336 RLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ----TPKSPPEHYVQETPLMFSRCTSVS 1391
Query: 1075 SLSS 1078
SL S
Sbjct: 1392 SLDS 1395
Score = 34.7 bits (78), Expect = 1.1
Identities = 49/203 (24%), Positives = 87/203 (42%), Gaps = 45/203 (22%)
Query: 968 DLDLPGCQAE-PPAREATSADARVRT-IKLSPTYQHVPLLEGASRAGAEPLAGPGISPGA 1025
D+DL +AE A+E ++A+V + +L+ Q + ++ +P+ P
Sbjct: 1871 DVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAK---QPINRGQPKPIL 1927
Query: 1026 RKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPS 1085
+KQ+ P +P++ AA + LQ A + P+ S SSLSSLS
Sbjct: 1928 QKQSTFPQSS-KDIPDRGAAT-----DEKLQNFAIENTPVCFSHNSSLSSLSDI------ 1975
Query: 1086 EGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPS 1145
D ++++ E ++E P +++ G S P A+
Sbjct: 1976 ---DQENNNKENEPIKETEPPDSQ--------GEPSKP-----------------QASGY 2007
Query: 1146 SSSENYVQETPLVLSRCSSVSSL 1168
+ +V++TP+ SR SS+SSL
Sbjct: 2008 APKSFHVEDTPVCFSRNSSLSSL 2030
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 120 bits (302), Expect = 1e-26
Identities = 299/1325 (22%), Positives = 439/1325 (33%), Gaps = 215/1325 (16%)
Query: 1040 PEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRP-GPSEGGDLDDSDSSLE 1098
PE L P SV K + Q P SL G P P++ G D ++
Sbjct: 512 PEDLKNLPSSVLVKFPTQKDLQTVPASLE-----------GAPFSPAQAGLTTKKDPTVL 560
Query: 1099 GLEEAGPSEA-ELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPL 1157
L +A P + ST +P +P++ A + G + P+SS +PL
Sbjct: 561 PLVQAAPKNSPSFQSTSSSP---EIPLSPEATLAKKSLGEPLPIGKPASS-----MTSPL 612
Query: 1158 VLSRCSSVSSLGSFESPS----------IASSIPSEPCSGQGSGTISPSELPDSPGQTMP 1207
++ +SV S+ P I ++ + P ++P+ + T
Sbjct: 613 GVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTT 672
Query: 1208 --PSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTV 1265
P T LAP E T +L + E C +
Sbjct: 673 ASPFLEGTVSLAPKNHPVKEGTLTTLPL---------VPTASENCPVA------------ 711
Query: 1266 EKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGP 1325
P +CA L+ L L + L P+ P G
Sbjct: 712 --PSPQNTCAP-LATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGIS--------HTSAL 760
Query: 1326 APTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQE 1385
AP S P+ E E GA+ A + + L L V V P P ++
Sbjct: 761 APVASSPK-------ECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRP-PTKK 812
Query: 1386 DDSCTDSAEG---TPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR 1442
+ D+ G +PV+ A+ L + +L + PA PT P S + A
Sbjct: 813 GSAGPDTPIGNLSSPVSPVEASFLPENSLSF--QGSKDSPATTHSPT--PPSPKGAPTPS 868
Query: 1443 HKAGGAGRSAEQSRGAGKNRAGLELPLGRP-PSAPADKDGSKPGRTRGDGALQSLCLTTP 1501
+ + + + LP + P+ PA K T TP
Sbjct: 869 AVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSS---PKKARATP 925
Query: 1502 TEEAVYCFYGNDSDEEPPAAAP--------TPTHRRTSAIPRAFTRERPQGRKEAPAPSK 1553
+ + PPAA P TP+ + + P A T P+G P+P K
Sbjct: 926 APKGIPASPSPKGAPTPPAATPPSPKGGPATPSPK-WAPTPPAATPPSPKGGPATPSP-K 983
Query: 1554 AAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAV--HPRGRE-PAVTKDP 1610
AP PPA T PS P + + +++ P P PA P+G P P
Sbjct: 984 GAPT--PPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPP 1041
Query: 1611 GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGE 1670
P G ++P P+ A + S P+ P L+ P G
Sbjct: 1042 SPKGSPAATPLPKGAPTTPAATLPS--PKGGPATPSLKGAPTPPAATPPSPKGGPATPSP 1099
Query: 1671 EAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTL 1730
+ A A+ S + + T H+ A T A+
Sbjct: 1100 KGAPMPPAATPPSPK--------GGLATPPHKGAPTTPAAT------------------- 1132
Query: 1731 QPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRG 1790
PP + G G+ P T SP+ P+G T P +G
Sbjct: 1133 -PPSPKGGLATPPPKGAPTTP-------AATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1184
Query: 1791 RTVIYVPSP-----APRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHR 1845
+ PSP P A P G ATP P PAA PSP + +
Sbjct: 1185 G--LATPSPKGAPTTPAATPPSPKGGLATPSPKGAP--TTPAATP--PSPKGGLATPSPK 1238
Query: 1846 PAKTSELATLSQPPRS-ATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPG 1904
A T+ AT P ATPP + A TP +++ + P + A P P
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPK 1298
Query: 1905 ASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEA-GP 1963
P +P + T SP P P PP AV P P+G A P
Sbjct: 1299 GGPA-TSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPP---AVTPPSPKGTPTLPATTP 1354
Query: 1964 GARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQ- 2022
++GG + S + G K P + + + +S +P+
Sbjct: 1355 SSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKK 1414
Query: 2023 ----------GASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQR-----PPAARPS 2067
A+P +G PAV S + +AP+ GPA + P PS
Sbjct: 1415 APATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPS 1474
Query: 2068 PGERPARR--TTSESPSRLPVR-APAARPETVKRYASLPHISVARRPDGAVPAAPASADA 2124
P E PA + TS SP + P AP P +LP + +P++P A
Sbjct: 1475 PKEPPAPKQVATSSSPKKAPATPAPMGAP-------TLPAV---------IPSSPKEVPA 1518
Query: 2125 ARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPR 2184
SS +P AP T +L PAT P P A P P+
Sbjct: 1519 T-PSSRRDP------IAPTAT-----------LLSKKTPATLAPKEALIP-PAMTVPSPK 1559
Query: 2185 KTSDAVVQTEEVAAPKTNSSTSPSLETREP-PGAPAGGQLSLLGSDVDGPSLAKAP---- 2239
KT E A P + ++SP T GAP+ +L L+ V PS +AP
Sbjct: 1560 KTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKEL-LIPPAVTSPSPKEAPTPPA 1618
Query: 2240 ISAPFVHEGLGV-AVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATAS 2298
++ P +G A G P S +PS S + P + + AT A++ PA
Sbjct: 1619 VTPPSPEKGPATPAPKGTPTSPPVTPS-SLKDSPTSPASVTCKMGATVPQASKGLPAKKG 1677
Query: 2299 ATLLE 2303
T L+
Sbjct: 1678 PTALK 1682
Score = 97.1 bits (240), Expect = 2e-19
Identities = 301/1383 (21%), Positives = 444/1383 (32%), Gaps = 206/1383 (14%)
Query: 862 SALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPE--GGRREAGSRAHPLLRLKAAH 919
S+L T + +F L S DP AP + S G + HP+
Sbjct: 638 SSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTT 697
Query: 920 ASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPP 979
L + + S + P PLA L E P+ P PS P +
Sbjct: 698 LPL----VPTASENCPVAPSPQNTCAPLATLVLAPEIPK-SVPSPSLPPAGTPPGTKKVD 752
Query: 980 AREATSADARVRTI-KLSPTYQHVPLLEGASRAGAEPLA------GPGISPGARKQAWLP 1032
TSA A V + K PT +S+ LA G +SP ++
Sbjct: 753 GISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKK 812
Query: 1033 ADHLSKVPEKLAAAPLSVASKAL---QKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGD 1089
P ++P+S + L+ Q S + S + S G P PS
Sbjct: 813 GSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTP 872
Query: 1090 LDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPA-----PRRNRGRGLGVEDATP 1144
L +L E PS L P AT P PA + R P
Sbjct: 873 LSPKGVTLPPKETPTPSVVNLPFPKEGP-ATPAPKQAPALSMTSSSPKKARATPAPKGIP 931
Query: 1145 SSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSE--PCSGQGSGTISPSELPDSP 1202
+S S P S + SP A + P+ P G T SP P P
Sbjct: 932 ASPSPKGAPTPPAATP--PSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPP 989
Query: 1203 GQTMPPSRSKTPPLAPAPQG---PPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAG 1259
T PPS K P P+P+G PP T S + F A PS G
Sbjct: 990 AAT-PPS-PKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPS--PKG 1045
Query: 1260 SVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHR 1319
S T + A++L P GG L A
Sbjct: 1046 SPAATPLPKGAPTTPAATL-----------------------PSPKGGPATPSLKGA--- 1079
Query: 1320 RREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPA 1379
PA T P+G G A P+ + P+P P+
Sbjct: 1080 --PTPPAATPPSPKG-------------GPATPS------------PKGAPMPPAATPPS 1112
Query: 1380 PAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAM 1439
P + T +G P ++ L PP G P P P S + +
Sbjct: 1113 P----KGGLATPPHKGAPTTPAATPPSPKGGLATPP--PKGAPT---TPAATPPSPKGGL 1163
Query: 1440 GHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLT 1499
G A + GL P P AP + P G L
Sbjct: 1164 ATPPPKGAPTTPAATPPSP---KGGLATP--SPKGAPTTPAATPPSPKGG--------LA 1210
Query: 1500 TPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR------AFTRERPQGRKEAPAPSK 1553
TP+ + + P A P+P + P+ A T P+G P P K
Sbjct: 1211 TPSPKG--------APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATP-PPK 1261
Query: 1554 AAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVH-PRGREPAVTKDPGP 1612
AP PPA T PSL P + + + + ++ P P PA P+G P
Sbjct: 1262 GAPT--PPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPS 1319
Query: 1613 GGGRDSSPSPRAAEELLQRCISSALPRRRP------PVSGLRRRKPRATRLDERPAEGSR 1666
G +P P+ A ++ P+ P P S P + PA
Sbjct: 1320 PKGSPGTPPPKGAP--TPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPS 1377
Query: 1667 ERGEEA---AGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
+G A R + S + + A TRE ++ G
Sbjct: 1378 HKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPS------KG 1431
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVK--TSGSPRSPAGPEK--PRGTQK 1779
+ P +K G P +G ++ T SP+ P P++ + K
Sbjct: 1432 DLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPK 1491
Query: 1780 TTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP--------RKVAPPCLAQPAA--P 1829
P PA + T+ V +P+ P TP R P K P LA A P
Sbjct: 1492 KAPATPAPMGAPTLPAVIPSSPKEVP-ATPSSRRDPIAPTATLLSKKTPATLAPKEALIP 1550
Query: 1830 AKVPSPGQQRSRSLHRPAK---TSELATLSQPP-------RSATPPARLAKTPSSSSSQT 1879
+ P +++ ++ P + T S PP + A P L P+ +S
Sbjct: 1551 PAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSP 1610
Query: 1880 SPASQPLPRKRPPVTQAAGALPGPGASPV--PKTPAR---TLLAKQHKTQRSPVRIPFMQ 1934
A P P PP + A P P +P P TP+ + + T + +P
Sbjct: 1611 KEAPTP-PAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQAS 1669
Query: 1935 R--PARRGPPPLARAVPEPGPRG----RAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
+ PA++GP L + P P A T GP + A++ + S +
Sbjct: 1670 KGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSS------ATSPPICPDPSAK 1723
Query: 1989 SGFRRQLTFIKESPGL--RRRRSELSSAESAASAPQG-ASPRRGRPALPAVFLCSSRCEE 2045
+G + L+ + +P L ++ S+ + + A+ +P+G +P + + P L ++ E+
Sbjct: 1724 NGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTP---LTAAAFEK 1780
Query: 2046 LRAAPRQ-----GPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA 2100
+ P P+P P A P P P ++ SP L + +P+
Sbjct: 1781 VLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPG-LVLESPSKPLAPADEDE 1839
Query: 2101 SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAP------GTTWRRIRDEDV 2154
LP I G VP + S G P P P P G+ DE V
Sbjct: 1840 LLPLIP-PEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESV 1898
Query: 2155 PHI 2157
P +
Sbjct: 1899 PEL 1901
Score = 56.2 bits (134), Expect = 4e-07
Identities = 221/1032 (21%), Positives = 350/1032 (33%), Gaps = 175/1032 (16%)
Query: 1382 PAQEDDSCTDSAEGTPVNFSSAASLSDETLQ-GPPRDQPGGPAGRQRPTGRPTSARQAMG 1440
PA E + AE + SSA S++ Q GP P PA +Q P ++A QA
Sbjct: 10 PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPL---SAANQASP 66
Query: 1441 HRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTT 1500
+ A E ++ +G LPLG P AP P + +L L +
Sbjct: 67 FPSPSTIASTPLEVP--FPQSSSGTALPLGTAPEAPT----FLPNLIGPPISPAALALAS 120
Query: 1501 PTEEAVYCFYGNDSDEEPPAAAPTPTH--RRTSAIPRAFTRERPQ--GRKEAPAPSKAAP 1556
P G S P A H +++SA P P + + +AP
Sbjct: 121 PM--IAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAP 178
Query: 1557 AAPPPARTQPSLIADE---------TPPCY-------------SLSSSASSLSEPEPSEP 1594
AP +T + + E +PPC S+ S +SL + P+
Sbjct: 179 IAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTT 238
Query: 1595 PAV-HPRGREPAVT----KDPGPGGGRDSSP-SPRAAEELLQRCISSALPRRRPPVSGLR 1648
A+ P+ ++ ++ PG P SP AA L + + ++
Sbjct: 239 LAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTP 298
Query: 1649 RRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATR 1708
P + P S + G S L + I +S +
Sbjct: 299 PDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIP 358
Query: 1709 EASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSP 1768
S ++ + + V+ V + P KG + + G+ +V TS S SP
Sbjct: 359 PLPSRNEVVPATVAAFPVVA----PSVDKGPSTISSITCS----PSGSLNVATSFS-LSP 409
Query: 1769 AGPEKPRGTQKTTPGVPAVLR------GRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPC 1822
+ + T P V + G T + V +P A T AT V+PP
Sbjct: 410 TTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVAT--CVSPPM 467
Query: 1823 LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSA----------TPPARLAKTP 1872
+ P + + SP + ++++AT + P S P + L K P
Sbjct: 468 SSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFP 527
Query: 1873 SSSSSQT----------SPASQPLPRKRP----PVTQAA----GALPGPGASP-VPKTPA 1913
+ QT SPA L K+ P+ QAA + +SP +P +P
Sbjct: 528 TQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPE 587
Query: 1914 RTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLV 1973
T LAK+ + P+ P + G A + + + AGP + G L
Sbjct: 588 AT-LAKKSLGEPLPIGKPASSMTSPLGVNSSASVI-------KTDSYAGPDSAGPLLKSS 639
Query: 1974 RVASALSS-GSESSDRSGFRRQLTFIKESPGLRRRRSELSSAES------AASAPQGASP 2026
+ +++ ES+D +G +P + S ++ S + AP+
Sbjct: 640 LITPTVAAFPLESADPAGV---------APTTAKGTSTYTTTASPFLEGTVSLAPKNHPV 690
Query: 2027 RRGR-PALPAVFLCSSRCEELRA----------------APRQGPAPARQRPPAARPSPG 2069
+ G LP V S C + P+ P+P+ PPA P PG
Sbjct: 691 KEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPS--LPPAGTP-PG 747
Query: 2070 ER--------PARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPAS 2121
+ A + SP P A T +L +++ + P G +
Sbjct: 748 TKKVDGISHTSALAPVASSPKECPTEDSGA-SATASSKGTLTYLADSPSPLGVSVSPQTK 806
Query: 2122 ADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGS------TPE 2175
++ S G P+ +++P V + S LP +L +GS T
Sbjct: 807 RPPTKKGSAGPDTPIGNLSSP-----------VSPVEASFLPENSLSFQGSKDSPATTHS 855
Query: 2176 DAPAGPPPRKTSDAV--VQTEEVAAPKTNSSTSPSLET----REPPGAPAGGQLSLLGSD 2229
P P T AV + + V P + T PS+ +E P PA Q L
Sbjct: 856 PTPPSPKGAPTPSAVTPLSPKGVTLPPKETPT-PSVVNLPFPKEGPATPAPKQAPALSMT 914
Query: 2230 VDGPSLAK---APISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATT 2286
P A+ AP P G PA+ SP P + P+P A T
Sbjct: 915 SSSPKKARATPAPKGIPASPSPKGAPTP--PAATPPSPKGGPATPSPKWAPTP---PAAT 969
Query: 2287 DSAAEKAPATAS 2298
+ + PAT S
Sbjct: 970 PPSPKGGPATPS 981
Score = 50.1 bits (118), Expect = 3e-05
Identities = 119/507 (23%), Positives = 171/507 (33%), Gaps = 64/507 (12%)
Query: 747 PPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPS---SLAAAAATGEPASPAAL- 802
PP A T P GLA + PS LA + G P +PAA
Sbjct: 1166 PPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP 1225
Query: 803 -----SLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQL 857
L SP A TPP+ +GG A G A L +A
Sbjct: 1226 PSPKGGLATPSPKGAPTTPAATPPSPKGGP-ATPPPKGAPTPPAATPPSLKGGLATPPHK 1284
Query: 858 VEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKA 917
A+ T ++ P + AP A SP +G G G+ P + +
Sbjct: 1285 GAPNPAVVTPPSPKGGPATSPP-KGAPTPPAATPPSP-KGSPGTPPPKGAPTPPAVTPPS 1342
Query: 918 AHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAE 977
+ + + S P P P AA S + P P P R G
Sbjct: 1343 PKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKR------GPAIP 1396
Query: 978 PPAREATSADARVRTIKLSPTYQHVPLL-EGASRAGAEPLAGPGISPGARKQAWLPADHL 1036
P + TS + K +P P+ EGA+ L P ++P + K+A PA
Sbjct: 1397 SPKGDPTSPAVIPLSPKKAPA---TPVTREGAATPSKGDLTPPAVTPVSLKKA--PA--- 1448
Query: 1037 SKVPEKLAAAPLSVASKALQKL---AAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDS 1093
+ P+ A P S L + + +E P +S S + P P
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA------ 1502
Query: 1094 DSSLEGLEEAGPSEAELDSTWR----APGATSLPVAIPAPRRNRGRGLGVEDATPSSSSE 1149
+L + + P E + R AP AT L PA + E P + +
Sbjct: 1503 -PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPK------EALIPPAMTV 1555
Query: 1150 NYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMP-P 1208
++TP + + + ++ S E+ S + PS G SP EL P T P P
Sbjct: 1556 PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTY-----KGAPSPKELLIPPAVTSPSP 1610
Query: 1209 SRSKTP-----------PLAPAPQGPP 1224
+ TP P PAP+G P
Sbjct: 1611 KEAPTPPAVTPPSPEKGPATPAPKGTP 1637
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 114 bits (285), Expect = 1e-24
Identities = 221/907 (24%), Positives = 310/907 (34%), Gaps = 135/907 (14%)
Query: 1349 AAVPARLRKVASALVPG-------RRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFS 1401
+A+ A R+ S PG RR+ + +P PAP+ T EG + S
Sbjct: 154 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT---EGPRKSVS 210
Query: 1402 SAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKN 1461
SA+ S R +P G QRP R S+ RS +RG
Sbjct: 211 SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT-----PLSSPARSGPSARGT--- 262
Query: 1462 RAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAA 1521
P APA KP +G AL+ +T P ++A S P A
Sbjct: 263 -----------PRAPAHPSQPKP---KGLQALRPPQVTPPRKDAAPALGPLSSS---PLA 305
Query: 1522 APTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPA--APPPARTQPSLIADETPPCYSL 1579
P+P+ + +P P P+P A P APP PSL +PP
Sbjct: 306 TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPP 365
Query: 1580 SSSASSLSEPEPSEPPAVH--PRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSAL 1637
S + S++ P PP++ P + P P + PSP A LQ S
Sbjct: 366 SQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP----SLQAPPSPLALSS-LQATTSLGS 420
Query: 1638 PRRRPPVSGLRRRKPRATRLD----ERPAEGSRERGE-EAAGSDRASDLDSVEWRAIQEG 1692
P + S L PR T+ RPA + +A S AS
Sbjct: 421 PTLQATHSFL-TMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSP 479
Query: 1693 ANSIVTWLHQAAAATREASSESDSILSFV--------SGLSVGSTLQPPKHRKGRQAEGE 1744
+S +T +H A + AS + LS + S L+ S PP E
Sbjct: 480 LSSPLT-IHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENL 538
Query: 1745 MGSARRPEKRGAASVKT----------------SGSPRSPAGPEKPRGTQKTTPGVPAVL 1788
A P + +A + T SP + PE P P P L
Sbjct: 539 PSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPAL 598
Query: 1789 RGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVP-----SPGQQRSRSL 1843
+ +PSP P TP P+A P PP A P+ PA P +P Q +L
Sbjct: 599 ASPPLQGLPSPP--LSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNAL 656
Query: 1844 HRPAKTSELATLSQPPRSA--TPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALP 1901
+ + PP A +PPA +PS++ +P S P + P + A
Sbjct: 657 AVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 716
Query: 1902 GPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQ---RPARRGPPPLARAVPEPGPRGRAG 1958
P A+P P+ P L A + SP P M P R PP LA + P A
Sbjct: 717 SPSATPPPQAPP-PLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPAS 775
Query: 1959 TEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAA 2018
P A+ +A+ L + P ++ S + S
Sbjct: 776 LPMSPLAKPPPQAPPALATP---------------PLQALPSPPASFPGQAPFSPSASLP 820
Query: 2019 SAPQGASPRRGRPALPAVFL-------CSSRCEELRAAPRQGPAPARQRPP---AARPSP 2068
+P P + P L A L S + R P GP + P A P P
Sbjct: 821 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 880
Query: 2069 GERPAR--RTTSESPSRLPVRAPA-ARPETVKRYASLPHISVARRPD------GAVPAAP 2119
P+R +T P + A + PE ++ Y S P A P PAA
Sbjct: 881 PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAW 940
Query: 2120 ASADA---ARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPED 2176
+ A A R + G P P P PG+ + + I + P +A P G+
Sbjct: 941 SRGPAPPLAFRGAPGAPLPWPPATGPGSA------DGLCTIYETEGPESATPAPGA---- 990
Query: 2177 APAGPPP 2183
GP P
Sbjct: 991 LDPGPSP 997
Score = 101 bits (251), Expect = 1e-20
Identities = 210/881 (23%), Positives = 298/881 (33%), Gaps = 175/881 (19%)
Query: 1552 SKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP- 1610
+KA AA PA P L+ P S P P P A+ G AV + P
Sbjct: 8 AKAGAAARTPAARAPGLLTPRPP---------GSPRPPPPVTPAALRVLGAAGAVGRKPL 58
Query: 1611 -----GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPA--- 1662
G GG +PRA SS P RPP SG R P A P
Sbjct: 59 AERAGGIGGATIPESAPRAGPTR-SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSP 117
Query: 1663 --------------EGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIV------TWLHQ 1702
+G R EE +A++ + + A+ GA T
Sbjct: 118 GRASGTTRPGPLGQKGLRISAEETVARGKATE--APKRSALSAGARRDTSGPTPGTPSPA 175
Query: 1703 AAAATREASSE---------------SDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGS 1747
A +R A +E ++ VS S ST +P + R + G G
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG--GG 233
Query: 1748 ARRPEKRGAASVKTS------------GSPRSPAGPE--KPRGTQKTTPGVPAVLRGRTV 1793
+RP R +S T G+PR+PA P KP+G Q P P V R
Sbjct: 234 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP--PQVTPPRKD 291
Query: 1794 IYVPSPAP-RAQPKGTPGPRATP-RKVAPPCLAQPAAPAKVP-SPGQQRSRSLHRPAKTS 1850
P+ P + P TP P T R V PP A PA +P SP L P+ ++
Sbjct: 292 A-APALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSA 350
Query: 1851 --ELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGA--- 1905
L TL PP ATPP++ + ++ Q P+ Q +P + P + + +L P +
Sbjct: 351 PPSLQTLPSPP--ATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLA 408
Query: 1906 -----------SPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP--PPLARAVPEPG 1952
SP + L +TQ S + RPA P PPL + P
Sbjct: 409 LSSLQATTSLGSPTLQATHSFLTMSPRQTQAS---LTSPSRPASTPPDSPPLQAPLSLPA 465
Query: 1953 P---RGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKES---PGLRR 2006
+ P + + ++ S+L+S S + S + S P L+
Sbjct: 466 SPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT 525
Query: 2007 RRSELSSAE------------SAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP 2054
+ L++ ASAP +P P PA + L P + P
Sbjct: 526 PPASLTTPPLENLPSLAPPPLQTASAPL-TTPHLETPPCPAPCPLQAPPSPLTTPPPETP 584
Query: 2055 APARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGA 2114
+ PP A P+ P + S S L P A P +LP + P +
Sbjct: 585 SSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL-----ALPPLQAPPSPPAS 639
Query: 2115 VPAAPASADAARR---------SSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPAT 2165
P +P + + + + P P P V AP + P +T P+
Sbjct: 640 PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP-----PASPPVSPSATPPSQ 694
Query: 2166 ALPLRGSTPEDAPAGPP-----------------PRKTSDAVVQTEEVAAPKTNSSTSPS 2208
A P + P P PP P V A+P + S +P
Sbjct: 695 APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754
Query: 2209 LET---------REPPGAPAGGQLSLLGSDVDG--PSLAKAPISAPFVHEGLGVAVGGFP 2257
+ PP PA +S L P+LA P+ A L FP
Sbjct: 755 PRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQA------LPSPPASFP 808
Query: 2258 ASRHGSPSRSARVPPFNYVP--SPMVVAATTDSAAEKAPAT 2296
SPS S + P P +P V+AA PA+
Sbjct: 809 GQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPAS 849
Score = 95.9 bits (237), Expect = 4e-19
Identities = 235/966 (24%), Positives = 319/966 (33%), Gaps = 176/966 (18%)
Query: 1384 QEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR- 1442
+ D + +A TP + A L G PR P R G A A+G +
Sbjct: 4 KRDKAKAGAAARTPA--ARAPGLLTPRPPGSPRPPPPVTPAALRVLG----AAGAVGRKP 57
Query: 1443 --HKAGGAGRSA--EQSRGAGKNRAG---LELPLGRPPS------APADKDGS-----KP 1484
+AGG G + E + AG R+ P RPP+ AP K+ S P
Sbjct: 58 LAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSP 117
Query: 1485 GRTRGD---GALQSLCLTTPTEEAVYCFYGNDSDEE-------------PPAAAPTPTHR 1528
GR G G L L EE V ++ + P P+P
Sbjct: 118 GRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 177
Query: 1529 RTS-------AIPRAFTRERPQGRKEAPAPSKAAPAA------PPPARTQPSLIAD-ETP 1574
R S +PR RP+ E P S ++ + P AR +PS + P
Sbjct: 178 RRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 237
Query: 1575 PCYSLSSSASSLSEPE------------PSEPPAVHPRG----REPAVT---KDPGPGGG 1615
SLSSSA+ LS P P+ P P+G R P VT KD P G
Sbjct: 238 ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 297
Query: 1616 RDSS-----PSP---RAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRE 1667
SS PSP +A ++ LP PP L P A P
Sbjct: 298 PLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTL 357
Query: 1668 RGEEAAGSDRASDLDSVEWRAIQEGANSI--VTWLHQAAAATREASSESDSILSFVSGLS 1725
A +A + +I + H + + +A ++ S + S
Sbjct: 358 PSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTS 417
Query: 1726 VGSTLQPPKHR----KGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPE-----KPRG 1776
+GS H RQ + + S RP S PA P P
Sbjct: 418 LGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAV 477
Query: 1777 TQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
+ ++P L+ + + SP P P T +APP L P PA + +P
Sbjct: 478 SPLSSPLTIHPLQALSSLASHSPQAPLSSLIMP-PLETQSSLAPPSLQTP--PASLTTPP 534
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQA 1896
+ SL P + A L+ P TPP P + SP + P PP T +
Sbjct: 535 LENLPSLAPPPLQTASAPLTTP-HLETPPC---PAPCPLQAPPSPLTTP-----PPETPS 585
Query: 1897 AGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGR 1956
+ A P P A P +P L SP+ P Q P PPL +A P P
Sbjct: 586 SIATPPPQAPPALASPP---LQGLPSPPLSPLATPPPQAPPXLALPPL-QAPPSPPASPP 641
Query: 1957 AGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAES 2016
A P + V + A S S Q F SP S ++ S
Sbjct: 642 LSPLATPSPQAPNALAVHLLQAPFSPPPSPPV-----QAPF---SPPASPPVSPSATPPS 693
Query: 2017 AASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRT 2076
A A P + P+ PA S P Q P P P PSP P
Sbjct: 694 QAPPSLAAPPLQVPPSPPA----SPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSP 749
Query: 2077 TSESPSRLP-------VRAPAARPETVKRYASLPHISVARRPDGAVPAA----------- 2118
++ P R+P ++ P + P ASLP +A+ P A PA
Sbjct: 750 SATPPPRVPPLLAAPPLQVPPSPP------ASLPMSPLAKPPPQAPPALATPPLQALPSP 803
Query: 2119 PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTL----------PATALP 2168
PAS S P+ +A P P +L + L P P
Sbjct: 804 PASFPGQAPFSPSASLPMSPLATP--------PPQAPPVLAAPLLQVPPSPPASPTLQAP 855
Query: 2169 LRGSTPED-------------APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPP 2215
R TP AP PPP S + + A ++S+TS E R
Sbjct: 856 RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 915
Query: 2216 GAPAGG 2221
P GG
Sbjct: 916 SGPEGG 921
Score = 87.4 bits (215), Expect = 1e-16
Identities = 201/855 (23%), Positives = 287/855 (33%), Gaps = 148/855 (17%)
Query: 1325 PAPTGSR------PRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVP 1378
P+P+G++ P AA L A P L + + P + LP P P
Sbjct: 307 PSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP-----P 361
Query: 1379 APAPAQEDDSCTDSAEGTPVNFSSAA------SLSDETLQGPPRDQPGGPAGRQRPTGRP 1432
A P+Q S T P + + SL+ +LQ PP P + Q T
Sbjct: 362 ATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPP--SPLALSSLQATTSLG 419
Query: 1433 TSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGA 1492
+ QA H Q+ +R P P AP S P +T A
Sbjct: 420 SPTLQAT---HSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPA 476
Query: 1493 LQSLC--LTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPA 1550
+ L LT +A+ + + P ++S P + + P P
Sbjct: 477 VSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSL--QTPPASLTTPP 534
Query: 1551 PSKAAPAAPPPARTQPSLIAD---ETPPCYS---LSSSASSLSEPEPSEPPAVHPRGREP 1604
APPP +T + + ETPPC + L + S L+ P P P ++
Sbjct: 535 LENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSI------- 587
Query: 1605 AVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEG 1664
++P P+A L + LP PP+S L P+A P
Sbjct: 588 -------------ATPPPQAPPALASPPLQG-LPS--PPLSPLATPPPQAPPXLALPPL- 630
Query: 1665 SRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGL 1724
+A S AS S + N++ L QA + +
Sbjct: 631 ------QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP------------ 672
Query: 1725 SVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPG- 1783
V + PP A + + P + S+ P+ P P + TP
Sbjct: 673 -VQAPFSPP-------ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 724
Query: 1784 -VPAVLRGRTVIYVPSP--APRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRS 1840
P L + PSP +P P TP PR P APP P+ PA +P
Sbjct: 725 QAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLP------- 777
Query: 1841 RSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGAL 1900
++ L++PP A PPA TP + + PAS P + P + +A
Sbjct: 778 -----------MSPLAKPPPQA-PPA--LATPPLQALPSPPASFP---GQAPFSPSASLP 820
Query: 1901 PGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTE 1960
P A+P P+ P L A + SP P +Q P R PP GPR
Sbjct: 821 MSPLATPPPQAPP-VLAAPLLQVPPSPPASPTLQAPRR--PPTPGPDTSVSGPRLTLALA 877
Query: 1961 AGPGARGGRLGLVRVASALSS---GSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESA 2017
GP R +S LS SS + +L P S AE A
Sbjct: 878 PGPPPPPSR----SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA 933
Query: 2018 ASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPA--------RQRPPAARPSPG 2069
A P A+ RG PA P F + L P GP A + P +A P+PG
Sbjct: 934 ACHP--AAWSRG-PAPPLAFR-GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 989
Query: 2070 ERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAP---------- 2119
+ S + A A + A L + P GA+ A+
Sbjct: 990 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGEL-----PLGALQASVVQHLLSRTLL 1044
Query: 2120 -ASADAARRSSDGEP 2133
A+A+ A S G P
Sbjct: 1045 LAAAEGAAGGSGGGP 1059
Score = 77.4 bits (189), Expect = 1e-13
Identities = 268/1140 (23%), Positives = 358/1140 (31%), Gaps = 199/1140 (17%)
Query: 838 AVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCR- 896
A A + LA I SA S SS +P P GR + P +
Sbjct: 49 AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKN 108
Query: 897 ---GPEG--GRREAGSRAHPL----LRLKA--------AHASLSNDSLNSGSASDGYCPR 939
GP GR +R PL LR+ A A + +L++G+ D P
Sbjct: 109 TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168
Query: 940 EHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPA---REATSADARVRTIKLS 996
P P A SR G PRP+ P + PP R++ S+ + T + S
Sbjct: 169 PGT-PSPAMARRSRAAGTEVGLPRPA------PSARPRPPTEGPRKSVSSASEHSTTEPS 221
Query: 997 PTYQHVPLLEG-----ASRA---GAEPLAGPGIS-PGARKQAWLPADHLSKVPEKLAAAP 1047
P + P G ASR+ A PL+ P S P AR PA P+ L A
Sbjct: 222 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281
Query: 1048 LSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSE 1107
+ + A GPLS S ++ S + RP P D++ + L P
Sbjct: 282 PPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPP----DNAATPLPATLPPSP-- 335
Query: 1108 AELDSTWRAPGATSLPVAIPAPRRNRG-RGLGVEDATPSS-------------------- 1146
P AT LP+A P+P + L ATP S
Sbjct: 336 ---------PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTI 386
Query: 1147 ----------SSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPS 1196
S +PL LS + +SLGS + S + P Q S T
Sbjct: 387 PPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLT---- 442
Query: 1197 ELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSEL 1256
P P T P S PL+ P PP T S S + L I + L S
Sbjct: 443 -SPSRPASTPPDSPPLQAPLS-LPASPPLQTSLS-PAVSPLSSPLTIHPLQALSSLASHS 499
Query: 1257 DAGSVRFTVEKPDENFSCASSLSALALHEHYVQQDV-ELRLLPSACPERGGGAGGAGLHF 1315
+ + P E SSL+ +L L LPS P
Sbjct: 500 PQAPLSSLIMPPLET---QSSLAPPSLQTPPASLTTPPLENLPSLAPP------------ 544
Query: 1316 AGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYM 1375
P T S P E P P A P P
Sbjct: 545 ---------PLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAP 595
Query: 1376 LVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSA 1435
A P Q S S TP + L+ LQ PP P P T P +
Sbjct: 596 PALASPPLQGLPSPPLSPLATPPP-QAPPXLALPPLQAPP-SPPASPPLSPLATPSPQAP 653
Query: 1436 RQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQS 1495
H +A + + ++ P P S P + P + A
Sbjct: 654 NALAVHLLQAPFSPPPSPP----------VQAPFSPPASPPVSPSATPPSQAPPSLAAPP 703
Query: 1496 LCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAA 1555
L P+ A S P+A P P A P P PA +
Sbjct: 704 L-QVPPSPPA--------SPPMSPSATPPPQAPPPLAAPPLQVPPSP------PASPPMS 748
Query: 1556 PAAPPPARTQPSLIAD--ETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPG 1613
P+A PP R P L A + PP S S L++P P PPA+ P + P P
Sbjct: 749 PSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPAL----ATPPLQALPSPP 804
Query: 1614 GGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAA 1673
+P + L + P + PPV A L P
Sbjct: 805 ASFPGQ-APFSPSASLPMSPLATPPPQAPPVLA-------APLLQVPP------------ 844
Query: 1674 GSDRASDLDSVEWRAIQEGANSIVTWLH-QAAAATREASSESDSILSFVSGLSV----GS 1728
S AS R G ++ V+ A A S S S +SG + S
Sbjct: 845 -SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS 903
Query: 1729 TLQPPKHRKGRQAEGEMGSARRPEKRG-AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAV 1787
P+ +G + E G+A P A+ + R PA P RG PG P
Sbjct: 904 ATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRG----APGAPL- 958
Query: 1788 LRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPA 1847
P P A G+ T + P A PA A P P S + A
Sbjct: 959 -----------PWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGG--KAA 1005
Query: 1848 KTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASP 1907
+ S+ P+ ARL + P + + Q L + + A GA G G P
Sbjct: 1006 AGAGAGASSRSPKQ----ARLGELPLGALQ--ASVVQHLLSRTLLLAAAEGAAGGSGGGP 1059
Score = 68.6 bits (166), Expect = 7e-11
Identities = 150/577 (25%), Positives = 210/577 (36%), Gaps = 71/577 (12%)
Query: 1745 MGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQ 1804
M + R K GAA+ + P P + P PA LR P A+
Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
Query: 1805 PKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSA-- 1862
G G P +AP P+ R A TS S+PP S
Sbjct: 61 RAGGIGGATIPE----------SAPRAGPT----------RSAGTSSRNPASRPPASGRG 100
Query: 1863 --TPPAR-LAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPG-ASPVPKTPARTLLA 1918
PPA+ + P SS + S ++P P + + +A G A+ PK A + A
Sbjct: 101 ERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGA 160
Query: 1919 KQHKTQRSP-VRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVAS 1977
++ + +P P M R +R + P P R R TE GP
Sbjct: 161 RRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE-GP------------RK 207
Query: 1978 ALSSGSESSDRSGFRRQLTFIKESPGLRRRRS-ELSSAESAASAPQGASP-RRGRPALPA 2035
++SS SE S GL+R S LSS+ + S+P + P RG P PA
Sbjct: 208 SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 267
Query: 2036 VFLCSSRCEELRA-APRQGPAPARQRPPAARP---SPGERPARRTTSESPSRLPVRAPAA 2091
+ + L+A P Q P + PA P SP P+ T P P A
Sbjct: 268 -HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATP 326
Query: 2092 RPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTT------ 2145
P A+LP P P +P SA + ++ P P A P T
Sbjct: 327 LP------ATLPPSPPLATPLPLAPPSP-SAPPSLQTLPSPPATPPSQAPPSMTTPPMQA 379
Query: 2146 ---WRRIRDEDVPHILRS-TLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKT 2201
+ I VPH L S +L A PL S+ + + P T A ++ +T
Sbjct: 380 PPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSP--TLQATHSFLTMSPRQT 437
Query: 2202 NSS-TSPSLETREPPGA-PAGGQLSLLGSDVDGPSLAKA--PISAPFVHEGLGVAVGGFP 2257
+S TSPS PP + P LSL S SL+ A P+S+P L A+
Sbjct: 438 QASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPL-QALSSLA 496
Query: 2258 ASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAP 2294
+ +P S +PP S + T A+ P
Sbjct: 497 SHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTP 533
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 102 bits (254), Expect = 4e-21
Identities = 365/1628 (22%), Positives = 566/1628 (34%), Gaps = 328/1628 (20%)
Query: 742 LEKQGPPAAE-AATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASPA 800
++ Q PP + +K P P + D L Q P SL+ A P
Sbjct: 999 VKAQTPPGPSLSGSKSPCPQEKSKDSLVQS------------CPGSLSLCAGVKSSTPPG 1046
Query: 801 ALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVED 860
+ S L+GQ+ +T P R DTS
Sbjct: 1047 ESYFGVSSLQLKGQS--QTSPDHRS------DTSSPE----------------------- 1075
Query: 861 ISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHA 920
+ S +S SL S Q +P+ GR++S SP E SR+ P+ + + +
Sbjct: 1076 ---VRQSHSESPSLQS--KSQTSPKGGRSRSSSPVT-------ELASRS-PIRQDRGEFS 1122
Query: 921 SLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDL-DLPGCQAEPP 979
+ S G P + ++ + + GQ SRL+ + A PP
Sbjct: 1123 A-------SPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQ---SRLETAESKEKMALPP 1172
Query: 980 AREATSADARVRTIKLSP-TYQHVP----LLEGASRAGAEPLAGPGISPGARKQ-AWLPA 1033
+AT++ R + K SP Q P + + R +G G SP ++Q + LP
Sbjct: 1173 QEDATASPPRQKD-KFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPT 1231
Query: 1034 DHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDS 1093
+ ++ A + L L+++ +S S S + RP S D S
Sbjct: 1232 SSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEE--RPAVSLTLDQSQS 1289
Query: 1094 DSSLEGLEEAGPSEAELDSTWRAPG-------ATSLPV-----AIPAPRRNRGRGLGVED 1141
+SLE +E PS A S+W P ++ P+ P RN G LG E
Sbjct: 1290 QASLEAVEV--PSMA---SSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGP-LGTEM 1343
Query: 1142 ATPSSSSENYVQETPLVLSRCSSVSSLGSFES-PSIASSIPSEPCSGQGSGTISPSELPD 1200
T SS P L E+ PS+ S SG S +SP + +
Sbjct: 1344 NTGFSSEVKEDLNGPF----------LNQLETDPSLDMKEQSTRSSGHSSSELSPDAV-E 1392
Query: 1201 SPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGS 1260
G + S S +P L P+ P S R R L GS
Sbjct: 1393 KAGMSSNQSIS-SPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGS 1451
Query: 1261 VRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRR 1320
P + SS ++ +P P RG +
Sbjct: 1452 -----GTPSRHSLSGSSPG--------------MKDIPRT-PSRGRSECDSS-------- 1483
Query: 1321 REEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYM----- 1375
E P RPR + EL +CL P R R + + V + P+
Sbjct: 1484 PEPKALPQTPRPRSRSPSSPELNNKCL---TPQRERSGSESSVDQKTVARTPLGQRSRSG 1540
Query: 1376 ------LVPAPAPAQ--EDDSCTDSAEGT--PVNFSSAASLSDE----TLQGPPRDQPGG 1421
+ P+ +P + E DS DS T P+ S + S E + P R + G
Sbjct: 1541 SSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGS 1600
Query: 1422 -PAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKD 1480
P + +P P + + A R+ + +G + G G P + +
Sbjct: 1601 SPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGR----GPSPEGSSSTE 1656
Query: 1481 GSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRE 1540
S + A + G+ S EP + TP RR+S TR+
Sbjct: 1657 SSPEHPPKSRTARR----------------GSRSSPEPKTKSRTPPRRRSSRSSPELTRK 1700
Query: 1541 RPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPR 1600
R+ A S P R++ TPP + S S SS PEP+E R
Sbjct: 1701 ARLSRRSRSASSS------PETRSR-------TPPRHRRSPSVSS---PEPAEKSRSSRR 1744
Query: 1601 GREPAVTKDPGPG-GGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDE 1659
R + + GR SP PR LQR S + RR K R TR +
Sbjct: 1745 RRSASSPRTKTTSRRGRSPSPKPRG----LQRSRSRS-----------RREKTRTTRRRD 1789
Query: 1660 R--PAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSI 1717
R ++ + R + + R + R + G+ H + A +E+S S
Sbjct: 1790 RSGSSQSTSRRRQRSRSRSRVT-------RRRRGGSG-----YHSRSPARQESSRTS--- 1834
Query: 1718 LSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGT 1777
S G + PP RK ++ +R R + + R+P + R
Sbjct: 1835 ----SRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPL-ISRRRSR 1889
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQ 1837
+T+P R RT + R++ + +P R R PP + + + ++ P+ +
Sbjct: 1890 SRTSPVSRRRSRSRTSV----TRRRSRSRASPVSRRRSRSRTPP-VTRRRSRSRTPTT-R 1943
Query: 1838 QRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKR-PPVTQA 1896
+RSRS P + RS TPP T S S+TSP ++ R R PVT+
Sbjct: 1944 RRSRSRTPP-------VTRRRSRSRTPPV----TRRRSRSRTSPITRRRSRSRTSPVTRR 1992
Query: 1897 AGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGR 1956
SPV + ++ +++ SPV +R R PP + R R R
Sbjct: 1993 RSR---SRTSPVTR--------RRSRSRTSPVT---RRRSRSRTPPAIRR-------RSR 2031
Query: 1957 AGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAES 2016
+ T P R R A+ S S R + + + P +RRR + SS++
Sbjct: 2032 SRTPLLPRKRSRS----RSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDR 2087
Query: 2017 AASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPA-RQRPP--------AARPS 2067
+ SA A+ P V L SSR + P P P R R P + P
Sbjct: 2088 SRSATPPATRNHSGSRTPPVALNSSRM-SCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPM 2146
Query: 2068 PGERPARRTTSESPS-RLPVRAPAARPET-VKRYASLPHISVARRPDGAVPAAPASADAA 2125
+ A + + P R+P + PE + +L +++ P+ A+ AA
Sbjct: 2147 SVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAA 2206
Query: 2126 RRSSDGEPRPLPRV-AAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPR 2184
R S P PL + AP L S +PA + PA P
Sbjct: 2207 RMSQVPAPVPLMSLRTAPAAN------------LASRIPAASAAAMNLASARTPAIPTAV 2254
Query: 2185 KTSD----AVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPI 2240
+D A +A+P+T + +PS P P ++L G+
Sbjct: 2255 NLADSRTPAAAAAMNLASPRT--AVAPSAVNLADPRTPTAPAVNLAGA------------ 2300
Query: 2241 SAPFVHEGLGVAVGGFP--ASRHGSPSRSARVPPFNYVPSPMVVAAT-------TDSAAE 2291
P L + G P A+ + S SR+ + P + P AT + +AA
Sbjct: 2301 RTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAA 2360
Query: 2292 KAPATASA 2299
APA+ ++
Sbjct: 2361 LAPASLTS 2368
Score = 99.0 bits (245), Expect = 5e-20
Identities = 204/863 (23%), Positives = 296/863 (34%), Gaps = 121/863 (14%)
Query: 1416 RDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSA 1475
R + PA + R R TSA A + RS +S A + L GR PS
Sbjct: 247 RSRSTTPAPKSRRAHRSTSADSA-----SSSDTSRSRSRSAAAKTHTTALA---GRSPSP 298
Query: 1476 PADKDG------SKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDE-EPPAAAPTPTHR 1528
+ + G S+PG T + T T++ + D D+ E A P+P+
Sbjct: 299 ASGRRGEGDAPFSEPGTT---STQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPE 355
Query: 1529 RTSA-----IPRAFTRERPQGRKE--APAPSKAAPAAPPPARTQPSLIADETPPCY--SL 1579
R+S P ER G + A P P PP ++ S D +PP L
Sbjct: 356 RSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPP---SEASPTRDRSPPKSPEKL 412
Query: 1580 SSSASSLSEPEPSEPPAV--HPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSAL 1637
S+SS S P +P V H + P PG R+ S SP + R
Sbjct: 413 PQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKS 472
Query: 1638 PRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIV 1697
P R R P + SR R G R+ S +WR + S
Sbjct: 473 HSHTPSRRMGRSRSPATAKRGR-----SRSRTPTKRGHSRSR---SPQWRR----SRSAQ 520
Query: 1698 TWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGR--QAEGEMGSARRPEKRG 1755
W ++ + R S S Q P + R Q G SARR
Sbjct: 521 RW-GRSRSPQRRGRSRSP---------------QRPGWSRSRNTQRRGRSRSARRGRSH- 563
Query: 1756 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP 1815
+ S T G RS + R +T PA R R+ +P R TP R
Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRT----PARRRSRS----RTPTRRRSRSRTPARRGRS 615
Query: 1816 RKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSS 1875
R P ++ SP ++RSRS PA+ S + P R +R S
Sbjct: 616 RSRTP-----ARRRSRTRSPVRRRSRS-RSPARRSGRSRSRTPARRGRSRSRTPARRGRS 669
Query: 1876 SSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQR 1935
S+T R R P + P ++ +R+L+ + R+P QR
Sbjct: 670 RSRTPARRSGRSRSRTPARRGRSRSRTPRRG---RSRSRSLVRRGRSHSRTP------QR 720
Query: 1936 PARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQL 1995
R G + R R+ + + P + R+ R S S S++ R RR L
Sbjct: 721 RGRSGSSSERKNKSRTSQR-RSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSL 779
Query: 1996 TFIKESPGLRRRRSELSSAESAASAPQGAS---PRRGRPALPAVFLCSSRCEELRAAPRQ 2052
+ P ++ ++ + S +S P+ S PRR R + S+ ++
Sbjct: 780 SGSSPCP-KQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSS 838
Query: 2053 GPAPARQ--RPP----AARPSPGER---PARRTTSES------PSRLPVRAPAARPETVK 2097
P P + PP P E+ P RR+ ES SR P R + +
Sbjct: 839 SPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPR 898
Query: 2098 RYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHI 2157
+S P R P A +RS G P P TT RR R
Sbjct: 899 VKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSN 958
Query: 2158 LRSTLPATALPLRGSTPEDAPAGP--PPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPP 2215
+ S L GS+ D P PPR++ + S P ++ + PP
Sbjct: 959 VESRL-LPRYSHSGSSSPDTKVKPETPPRQSHSGSI------------SPYPKVKAQTPP 1005
Query: 2216 GAPAGGQLSLLGSDVDGPSLAKA 2238
G G S + SL ++
Sbjct: 1006 GPSLSGSKSPCPQEKSKDSLVQS 1028
Score = 90.9 bits (224), Expect = 1e-17
Identities = 165/697 (23%), Positives = 243/697 (34%), Gaps = 89/697 (12%)
Query: 1570 ADETPPCYSLSSSASSLSEPEPSEPPAVHP--RGREPAVTKDPGPGGGRDSSPSPRAAEE 1627
A E P YSL +SS P P + RGR + R+ E
Sbjct: 164 APEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESE 223
Query: 1628 LLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWR 1687
+R S P+ + +R++ R+T PA SR R + +D AS D+ R
Sbjct: 224 SKKRKHRSPTPKSKRKSKDKKRKRSRSTT----PAPKSR-RAHRSTSADSASSSDTSRSR 278
Query: 1688 AIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGS 1747
+ A + T L A + AS + S ST +P +
Sbjct: 279 SRSAAAKTHTTAL--AGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYE 336
Query: 1748 ARRPEKRGAASVKTSGSP-RSPAGPEKPRGTQ-------------KTTP---------GV 1784
+ +K+ ++ + S SP RS GPE P T TTP
Sbjct: 337 DKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE 396
Query: 1785 PAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLH 1844
+ R R+ P P++ + P P KV+ + P +P P+PG R S
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSS 456
Query: 1845 RPAKT-SELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGP 1903
+K S S TP R+ ++ S ++++ + P KR G
Sbjct: 457 PTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKR-----------GH 505
Query: 1904 GASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGP 1963
S P Q + RS R + P RRG +R+ PG T+
Sbjct: 506 SRSRSP----------QWRRSRSAQRWGRSRSPQRRG---RSRSPQRPGWSRSRNTQRRG 552
Query: 1964 GARGGRLGLVRVASALSSG---SESSDRSGFRRQLTFIK-----ESPGLRRRRSELSSAE 2015
+R R G S + G S + R G R T + +P RR RS + A
Sbjct: 553 RSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSR-TPAR 611
Query: 2016 SAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQ-----RPPAARPSPGE 2070
S + + RR R P SR R+ + PAR+ R PA R
Sbjct: 612 RGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRS 671
Query: 2071 RPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVAR-RPDGAVP----AAPASADAA 2125
R R + S SR P R +R T +R S V R R P + +S++
Sbjct: 672 RTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERK 731
Query: 2126 RRSSDGEPR----PLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTP-EDAPAG 2180
+S + R P + + RR R P + + L GS+P +
Sbjct: 732 NKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQ 791
Query: 2181 PPPRKTSDAVVQTEEVAAPKTNSSTSP--SLETREPP 2215
PPR++ Q PK S T P S + PP
Sbjct: 792 TPPRRSRSGSSQ------PKAKSRTPPRRSRSSSSPP 822
Score = 85.9 bits (211), Expect = 4e-16
Identities = 155/690 (22%), Positives = 238/690 (34%), Gaps = 125/690 (18%)
Query: 1298 PSACPERGGGA--GGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLREC--LGAAVPA 1353
P + ++ GG+ G G H+R S P A + L LG A P
Sbjct: 2145 PMSVLQQAGGSMMDGPGPRIPDHQRT--------SVPENHAQSRIALALTAISLGTARPP 2196
Query: 1354 RLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQG 1413
A+ L +P PV ++ APA S +A +N +SA
Sbjct: 2197 PSMS-AAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASA---------- 2245
Query: 1414 PPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPP 1473
R PT+ A A A A + L P R P
Sbjct: 2246 -------------RTPAIPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADP--RTP 2290
Query: 1474 SAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAI 1533
+APA R AL +L LT PP AA P+ RT
Sbjct: 2291 TAPAVNLAG----ARTPAALAALSLT--------------GSGTPPTAANYPSSSRTPQA 2332
Query: 1534 PRAFTRERPQGRKEAPAP---------SKAAPAAPPPARTQPSLI-ADETPPCYSLSSSA 1583
P + P+ A AP + APA+ AR P+L A+ T P LS+
Sbjct: 2333 PASANLVGPRSA-HATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYE 2391
Query: 1584 SSLSEPEPSEPPAVHPRGREP-AVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRP 1642
P P R R P + R SPS R + Q + A + R
Sbjct: 2392 RVSGRTSP--PLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRS 2449
Query: 1643 PVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQ 1702
PV + R P GS+ ++ GA
Sbjct: 2450 PVPSAFSDQSRCLIAQTTPVAGSQ---------------------SLSSGA--------- 2479
Query: 1703 AAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTS 1762
A T ++ + + +LS + S + P G Q + +A +P K +S +S
Sbjct: 2480 -VATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSAL-AALQPAKERRSSSSSS 2537
Query: 1763 GSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPC 1822
S S + + ++ + G ++ P A + P TP P+ R+ PP
Sbjct: 2538 SSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPP- 2596
Query: 1823 LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPA 1882
P+P +++ RS + +S ++ S S++ + + + SSSSS +S +
Sbjct: 2597 ---------EPTPAKRKRRS-SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646
Query: 1883 SQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLA-KQHKTQRSPVRIPFMQRPARRGP 1941
S P P K PGP A P P +P + ++ ++ R P+ R P
Sbjct: 2647 SSPSPAK-----------PGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695
Query: 1942 PPLARAVPEPGPRGRAGTEAGPGARGGRLG 1971
R P+P PR + + + G+R G+ G
Sbjct: 2696 VERRRPSPQPSPRDQQSSSSERGSRRGQRG 2725
Score = 79.0 bits (193), Expect = 5e-14
Identities = 316/1422 (22%), Positives = 475/1422 (33%), Gaps = 244/1422 (17%)
Query: 867 SSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAG--SRAHPLLRLKAAHASLSN 924
SS+ S S D P R+ S S +G R SR+ L+ + S
Sbjct: 1397 SSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSR 1456
Query: 925 DSLNSGSASDGYCPREHMLPCPLAALASRREDPRC--GQPRPSRLDLDLPGCQAE--PPA 980
SL+ S PR P + +P+ PRP P + P
Sbjct: 1457 HSLSGSSPGMKDIPRT---PSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQ 1513
Query: 981 REATSADARV--RTIKLSPTYQHVPLLEGASRAGA--EPLAGPGISPGARKQAWLPADHL 1036
RE + +++ V +T+ +P Q SR+G+ E P SP R ++ D
Sbjct: 1514 RERSGSESSVDQKTVARTPLGQR-------SRSGSSQELDVKPSASPQERSESDSSPDSK 1566
Query: 1037 SKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSS 1096
+K L S +S + + LS R S SS +P + SDSS
Sbjct: 1567 AKTRTPLRQRSRSGSSPEVDS----KSRLSPRRSRSGSSPEVKDKPRAAPRAQ-SGSDSS 1621
Query: 1097 LEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETP 1156
E +AP +LP + ++GRG E SSS+E+ + P
Sbjct: 1622 PEP---------------KAPAPRALPRRSRSGSSSKGRGPSPEG---SSSTESSPEHPP 1663
Query: 1157 LVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPS---ELPDSPGQTMPPSRSKT 1213
SR + S S E P S P S + S ++ + P +RS+T
Sbjct: 1664 K--SRTARRGSRSSPE-PKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRT 1720
Query: 1214 PPL---APAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDE 1270
PP +P+ P A + R R PS G R E
Sbjct: 1721 PPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRRE 1780
Query: 1271 NFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAG--------GAGLHFAGHRRRE 1322
+ ++ R R GG+G + RRR
Sbjct: 1781 KTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRG 1840
Query: 1323 EGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASA--LVPGRRALPVPVYMLVPAP 1380
P SR R + + A PA R+ S L+ RR+ +P
Sbjct: 1841 RSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRT------SP 1894
Query: 1381 APAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPP----RDQPGGPAGRQRPTGR--PTS 1434
+ S T + +S S + PP R + P R+R R P +
Sbjct: 1895 VSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVT 1954
Query: 1435 ARQAMGHRH---KAGGAGRSAEQSRGAGKNRAG-LELPLGRPPSAPADKDGSKPGRTRGD 1490
R++ + R++ +R ++R + R ++P + S+ RT
Sbjct: 1955 RRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSR-SRTSPV 2013
Query: 1491 GALQSLCLTTP-----TEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR---AFTRERP 1542
+S T P + S P A + RT R + TR P
Sbjct: 2014 TRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPP 2073
Query: 1543 QGRKEAPAPSKA--APAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPR 1600
R+ + + S + + +A PPA S TPP SS S S P S P R
Sbjct: 2074 AIRRRSASGSSSDRSRSATPPATRNHS--GSRTPPVALNSSRMSCFSRPSMSPTPL--DR 2129
Query: 1601 GREPAVTKDPGP-----------GGGRDSSPSPR-------------AAEELLQRCISSA 1636
R P + + G GG P PR A + + +
Sbjct: 2130 CRSPGMLEPLGSSRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAIS 2189
Query: 1637 LPRRRPPVS----GLRRRKPRATR----LDERPAEGSRERGEEAAGSDRASDLDSVEWRA 1688
L RPP S GL R + + R A + A S A +L S A
Sbjct: 2190 LGTARPPPSMSAAGLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPA 2249
Query: 1689 IQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSA 1748
I N + AAAA AS + S V+ + P + G A
Sbjct: 2250 IPTAVNLADSRTPAAAAAMNLASPRTAVAPSAVNLADPRTPTAPAVNLAG---------A 2300
Query: 1749 RRPEKRGAASVKTSGSP----------RSPAGPEK-----PRGTQKTTPGVPAVLRGRTV 1793
R P A S+ SG+P R+P P PR T P A R
Sbjct: 2301 RTPAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAA 2360
Query: 1794 IYVPS-PAPRAQPKGTPGPRATPR-----------KVAPPCLAQPAAPAKVPSPGQQRSR 1841
+ S + R P + +PR + +PP L + + +P Q R
Sbjct: 2361 LAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMT 2420
Query: 1842 SLHRPAKTSELATLSQPPRSATPPAR---LAKTPSSSS-------SQTSPA--SQPLPRK 1889
S P+ +S + P +S PPA+ + PS+ S +QT+P SQ L
Sbjct: 2421 SERAPSPSSRMG--QAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSG 2478
Query: 1890 R-PPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPP-PLARA 1947
T +AG G + P P P H P PA G P A A
Sbjct: 2479 AVATTTSSAGDHNGMLSVPAPGVP--------HSDVGEP--------PASTGAQQPSALA 2522
Query: 1948 VPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFR--------------- 1992
+P R+ + + + +S+ SSGS SSD G
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582
Query: 1993 --------RQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCE 2044
R+ + +P R+RRS SS+ S++S+ +S + + SS
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSS---SSSSSS 2639
Query: 2045 ELRAAPRQGPAPARQRPPA-------ARPSPGERPARRTTSESPSRLPVRAPAARPETVK 2097
++ P+PA+ P A +P PGER +R SP R P+ ++++
Sbjct: 2640 SSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSR-----SP-RKPI-------DSLR 2686
Query: 2098 RYASLPHISVARRPDGAVPA-----APASADAARRSSDGEPR 2134
SL + V RR P+ + +S +RR G+ R
Sbjct: 2687 DSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSR 2728
Score = 70.5 bits (171), Expect = 2e-11
Identities = 289/1342 (21%), Positives = 444/1342 (33%), Gaps = 196/1342 (14%)
Query: 976 AEPPAREATSADARVRTIKLSPTYQHVPLLEGASRA----GAEPLAGPGIS-PGARKQAW 1030
+ P R+ + +R SP + +P R+ EP A P P +R +
Sbjct: 1443 SSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSS 1502
Query: 1031 LPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDL 1090
++ P++ + S QK A+ SR S L P E +
Sbjct: 1503 PELNNKCLTPQRERSGSESSVD---QKTVARTPLGQRSRSGSSQELDVKPSASPQERSES 1559
Query: 1091 DDSDSS-------LEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNR-GRGLGVED- 1141
D S S L +G S E+DS R +PRR+R G V+D
Sbjct: 1560 DSSPDSKAKTRTPLRQRSRSG-SSPEVDSKSRL-----------SPRRSRSGSSPEVKDK 1607
Query: 1142 --ATP-----SSSSENYVQETPLVLSRCS--SVSSLGSFESPSIASSIPSEPCSGQGSGT 1192
A P S SS P L R S SS G SP +SS S P S T
Sbjct: 1608 PRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRT 1667
Query: 1193 ISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRE-RCR 1251
S P ++S+TPP + + PE T+ + +R + E R R
Sbjct: 1668 ARRG----SRSSPEPKTKSRTPPRRRSSRSSPELTRKA----RLSRRSRSASSSPETRSR 1719
Query: 1252 LPSELDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGA 1311
P +V P+ SS + + PS P
Sbjct: 1720 TPPRHRRSP---SVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPR-------- 1768
Query: 1312 GLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPV 1371
GL + R R E T R R + Q R+ R + + V RR
Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQ----------RSRSRSRVTRRRRGGS 1818
Query: 1372 PVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGR 1431
+ + +PA+++ S T S + + S + P + T R
Sbjct: 1819 GYH----SRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHR 1874
Query: 1432 PTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDG 1491
+ +R + R ++ R++ SR ++R + R ++P + S+ RT
Sbjct: 1875 RSRSRTPLISRRRS--RSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSR-SRTPPVT 1931
Query: 1492 ALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAP 1551
+S T T + + P T RR+ + TR R + R
Sbjct: 1932 RRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTR 1991
Query: 1552 SKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPG 1611
++ P R + T P S + + PPA+ R R ++ P
Sbjct: 1992 RRSRSRTSPVTRRRSR---SRTSPVTRRRSRSRT--------PPAIRRRSR----SRTPL 2036
Query: 1612 PGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEE 1671
R S SP A ++R S PR L R P R R A GS
Sbjct: 2037 LPRKRSRSRSPLA----IRRRSRSRTPRTARGKRSLTRSPPAIRR---RSASGSSSDRSR 2089
Query: 1672 AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQ 1731
+A + + ++ + + + + T S +L +GS+
Sbjct: 2090 SATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLE-----PLGSSRT 2144
Query: 1732 PPKHRKGRQAEGEMGSARRPE----KRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAV 1787
P + QA G M P +R + + S + A GT + P + A
Sbjct: 2145 PMSVLQ--QAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAA 2202
Query: 1788 LRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS-PGQQRSRSLHRP 1846
+ VP+P P + P R A A A A+ P+ P P
Sbjct: 2203 GLAARMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTP 2262
Query: 1847 AKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGAS 1906
A + + S PR+A P+ A + + T+PA L R P AA +L G G
Sbjct: 2263 AAAAAMNLAS--PRTAVAPS--AVNLADPRTPTAPAVN-LAGARTPAALAALSLTGSGTP 2317
Query: 1907 PVPKTPARTLLAKQHKTQRSPVRIPFMQRPARR---GPPPLARAVPEPGPRGRAGTEAGP 1963
P A + R+P Q PA GP R+ P AG+
Sbjct: 2318 PTA--------ANYPSSSRTP------QAPASANLVGP----RSAHATAPVNIAGSRTAA 2359
Query: 1964 GARGGRLGLVRVASALSSGSESSDR---SGFRRQLTFIKESPGLRRRRSEL--------- 2011
L R+A ALS + +S R S + R ++ P L R RS
Sbjct: 2360 ALAPASLTSARMAPALSGANLTSPRVPLSAYER-VSGRTSPPLLDRARSRTPPSAPSQSR 2418
Query: 2012 --SSAESAASAPQGASPRRG---------RPALPAVFLCSSRCEELRAAPRQGPAPARQR 2060
S + S+ G +P + R +P+ F SRC + P G
Sbjct: 2419 MTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSG 2478
Query: 2061 PPAAR-------------PSPGE------RPARRTTSESPSRLPVRAPAARPETVKRYAS 2101
A P+PG P T ++ PS L PA +R +S
Sbjct: 2479 AVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAK-----ERRSS 2533
Query: 2102 LPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRST 2161
S + + ++ +S+ + SSD E LP P +R+ S
Sbjct: 2534 SSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP--VQPEVALKRVP---------SP 2582
Query: 2162 LPATALPLR-GSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAG 2220
PA +R G PE PA R +S + + ++ ++SS+S S + + +
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642
Query: 2221 GQLSLLGSDV-DGPSLAKAPIS 2241
S S GP P S
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPAS 2664
Score = 61.6 bits (148), Expect = 9e-09
Identities = 224/1016 (22%), Positives = 335/1016 (32%), Gaps = 169/1016 (16%)
Query: 1379 APAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPP------RDQPGGPAGRQRPTGRP 1432
+P+PA D+ P S+ S ET P +D+ RP+ P
Sbjct: 295 SPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPS--P 352
Query: 1433 TSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLEL---PLGRPPSAPADKDGSKPGRTRG 1489
+ R + G A AE+ G+ + A L P+ P A +D S P
Sbjct: 353 SPERSSTGPEPPAP-TPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEK 411
Query: 1490 DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTP-THRRTSAIPRAFTRERPQGRKE- 1547
S + P+ + S E P AP P +HR S+ P + R + +++
Sbjct: 412 LPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDK 471
Query: 1548 --APAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSAS-------SLSEPEPSEPPAVH 1598
+ PS+ + PA + TP S S S S S P
Sbjct: 472 SHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRR 531
Query: 1599 PRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLD 1658
R R P PG R + R +R S + R P G R + A R
Sbjct: 532 GRSRSPQ-----RPGWSRSRNTQRRGRSRSARRGRSHS---RSPATRGRSRSRTPARRGR 583
Query: 1659 ERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSIL 1718
R +R R + R S + R + R + S S +
Sbjct: 584 SRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARR 643
Query: 1719 SFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQ 1778
S G + R+GR ARR R + SG RS + R
Sbjct: 644 S-------GRSRSRTPARRGRSRSRT--PARRGRSRSRTPARRSGRSRSRTPARRGRSRS 694
Query: 1779 KT-----TPGVPAVLRGRTVIYVPSPAPRA------QPKGTPGPRATPRKVAPPC----- 1822
+T + V RGR+ P R+ + K R + +P
Sbjct: 695 RTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRI 754
Query: 1823 -------LAQPAAPAKV------------PSPGQ--QRSRSLHRPAKTSELATLSQPPR- 1860
L+ P + AK P P Q Q R + A PPR
Sbjct: 755 SSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRR 814
Query: 1861 ----SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGA----------- 1905
S+ PP + +KTP S Q+ +S P P+ + G++ P A
Sbjct: 815 SRSSSSPPPKQKSKTP---SRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRS 871
Query: 1906 ----SPVPKTPARTLLAKQHKTQRSPVRI----PFMQRPAR-RGPPPLARAVPEPGPRGR 1956
SP P+ +RT ++ + SP R+ P Q P+R P P +A+ P R
Sbjct: 872 CFESSPDPELKSRT-PSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSH 930
Query: 1957 AGTEAGPGARGGRLGLVRVASALSSGSESSDR-------SGFRRQLTFIK-ESPGLRRRR 2008
+G+ + +R R + ++S S R SG T +K E+P +
Sbjct: 931 SGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHS 990
Query: 2009 SELSS-AESAASAPQGASPRRGRPALP-------AVFLCS---SRCEELRAAPRQGPA-- 2055
+S + A P G S + P V C S C ++++ G +
Sbjct: 991 GSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYF 1050
Query: 2056 --------PARQRPPAARPSPGERPARRTTSESP---SRLPVRAPAARPETVKRYASLPH 2104
Q P R R++ SESP S+ R + L
Sbjct: 1051 GVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELAS 1110
Query: 2105 ISVARRPDGAVPAAP-----ASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILR 2159
S R+ G A+P S + +R SD P + + R E +
Sbjct: 1111 RSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYP---TVDSNSLLGQSRLETAESKEK 1167
Query: 2160 STLP----ATALPLRGSTP------EDAPAG---------PPPRKTSDA---VVQTEEVA 2197
LP ATA P R +D P PPR+ S A E+ +
Sbjct: 1168 MALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNS 1227
Query: 2198 APKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAV 2253
A T+S +E E PAG LS L S++ S + S+P V E V++
Sbjct: 1228 ALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFE-SSPEVEERPAVSL 1282
Score = 58.9 bits (141), Expect = 6e-08
Identities = 132/561 (23%), Positives = 186/561 (33%), Gaps = 123/561 (21%)
Query: 784 PSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKA 843
P++LAA + TG P A + S Q A A R A + +G AA A
Sbjct: 2303 PAALAALSLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALA 2362
Query: 844 KAKLALAVARIDQLVEDISALHTSSD----DSFSLSSGDPGQEAPREGRAQSCSPCRGPE 899
A L A ++ +S + +S ++ SG P RA+S +P P
Sbjct: 2363 PASLTSA-----RMAPALSGANLTSPRVPLSAYERVSGRTSP--PLLDRARSRTPPSAPS 2415
Query: 900 GGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRC 959
R ++++ S S+ G P + +LP ++ PR
Sbjct: 2416 QSR-------------------MTSERAPSPSSRMGQAPSQSLLP-------PAQDQPR- 2448
Query: 960 GQPRPSRLDLDLPGC---QAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPL 1016
P PS D C Q P A + + V T S + L A +
Sbjct: 2449 -SPVPSAFS-DQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDV 2506
Query: 1017 AGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSL 1076
P S GA++ P LAA + ++ ++ S S SS SS
Sbjct: 2507 GEPPASTGAQQ------------PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSS 2554
Query: 1077 SSAGRPGPSEGGDLD-DSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGR 1135
SS SEG L + +L+ + P+ E R P T PA R+ R
Sbjct: 2555 SSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPT------PAKRKRRS- 2607
Query: 1136 GLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISP 1195
SSSS + S SS SS S S S +SS S S S + SP
Sbjct: 2608 ---------SSSSSS---------SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649
Query: 1196 SELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSE 1255
S P P+ K PP P E
Sbjct: 2650 SPAKPGPQALPKPASPKKPP-------------------------------------PGE 2672
Query: 1256 LDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAG-LH 1314
+ S R KP ++ + SLS + R S+ ERG G G
Sbjct: 2673 RRSRSPR----KPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSR 2728
Query: 1315 FAGHRRREEGPAPTGSRPRGA 1335
H+RR E P+P R R +
Sbjct: 2729 SPSHKRRRETPSPRPMRHRSS 2749
Score = 38.1 bits (87), Expect = 0.10
Identities = 47/211 (22%), Positives = 76/211 (36%), Gaps = 5/211 (2%)
Query: 736 AQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGE 795
A + H + PPA+ A + L L + +S S + SS ++++++
Sbjct: 2498 APGVPHSDVGEPPASTGAQQPSA--LAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS 2555
Query: 796 PASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARID 855
S ++ S P AL R P KEA ++ AK K + + + +
Sbjct: 2556 SGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSS 2615
Query: 856 QLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRL 915
S+ +SS S S SS + P GP+ + A + P
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP--GPQALPKPASPKKPPPGER 2673
Query: 916 KAAHASLSNDSLNSGSASDGYCPREHMLPCP 946
++ DSL S S Y P E P P
Sbjct: 2674 RSRSPRKPIDSLRD-SRSLSYSPVERRRPSP 2703
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 97.1 bits (240), Expect = 2e-19
Identities = 184/752 (24%), Positives = 250/752 (33%), Gaps = 151/752 (20%)
Query: 1552 SKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP- 1610
+KA AA PA P L+ P S P P P A+ G AV + P
Sbjct: 8 AKAGAAARTPAARAPGLLTPRPP---------GSPRPPPPVTPAALRVLGAAGAVGRKPL 58
Query: 1611 -----GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPA--- 1662
G GG +PRA SS P RPP SG R P A P
Sbjct: 59 AERAGGIGGATIPESAPRAGPTR-SAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSP 117
Query: 1663 --------------EGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIV------TWLHQ 1702
+G R EE +A+ ++ + A+ GA T
Sbjct: 118 GRASGTTRPGPLGQKGLRISAEETVARGKAT--EAPKRSALSAGARRDTSGPTPGTPSPA 175
Query: 1703 AAAATREASSE---------------SDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGS 1747
A +R A +E ++ VS S ST +P + R + G G
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG--GG 233
Query: 1748 ARRPEKRGAASVKT------------SGSPRSPAGPE--KPRGTQKTTP---------GV 1784
+RP R +S T G+PR+PA P KP+G Q P
Sbjct: 234 LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAA 293
Query: 1785 PAV-LRGRTVIYVPSPAPRAQPKGTPGPRATPR------KVAPPCLAQPAAPAKVPS--- 1834
PA+ + + PSP+ Q + P ATP ++A P P +P+ PS
Sbjct: 294 PALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQT 353
Query: 1835 -------PGQQRSRSLHRPAKTSELATLSQPPRS--ATPPARLAKT---PSSSSSQTSPA 1882
P Q + SL P + + L PP S ATPP + P + + PA
Sbjct: 354 LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 413
Query: 1883 SQPLPRKRPPVTQAAGALP----GPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPAR 1938
S PL P QA AL SP P P + + SP P Q P
Sbjct: 414 SPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 473
Query: 1939 RGPPPL-----ARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRR 1993
PPL A P P +A P L L + +
Sbjct: 474 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP------- 526
Query: 1994 QLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFL-------CSSRCEEL 2046
L + P ++ S + S +P P + P L A L S +
Sbjct: 527 PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586
Query: 2047 RAAPRQGPAPARQRPP---AARPSPGERPAR--RTTSESPSRLPVRAPA-ARPETVKRYA 2100
R P GP + P A P P P+R +T P + A + PE ++ Y
Sbjct: 587 RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYD 646
Query: 2101 SLPHISVARRPD------GAVPAAPASADA---ARRSSDGEPRPLPRVAAPGTTWRRIRD 2151
S P A P PAA + A A R + G P P P PG+
Sbjct: 647 SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSA------ 700
Query: 2152 EDVPHILRSTLPATALPLRGSTPEDAPAGPPP 2183
+ + I + P +A P G+ GP P
Sbjct: 701 DGLCTIYETEGPESATPAPGA----LDPGPSP 728
Score = 77.0 bits (188), Expect = 2e-13
Identities = 154/628 (24%), Positives = 215/628 (34%), Gaps = 124/628 (19%)
Query: 1745 MGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLR--------GRTVI-- 1794
M + R K GAA+ + P P + P PA LR GR +
Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
Query: 1795 --------YVPSPAPRAQPKGTPGPRATPRKVAPPC--LAQPAAPAKVPSPGQQRSRSLH 1844
+P APRA P + G + PP + A PAK SPG S
Sbjct: 61 RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPG-- 118
Query: 1845 RPAKTSELATLSQ-------------------PPRSATPPARLAKTPSSSSSQTSPASQP 1885
R + T+ L Q P RSA A+ +S + +P+
Sbjct: 119 RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAG--ARRDTSGPTPGTPSPAM 176
Query: 1886 LPRKRPPVTQAAGALPGPGASPVPKT--PARTL-LAKQHKT-------QRSPVRIPFMQR 1935
R R T+ P P A P P T P +++ A +H T +R P +QR
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236
Query: 1936 PARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFR-RQ 1994
PA R A + P +GP ARG A A S + R Q
Sbjct: 237 PASRSLSSSATPLSSP-------ARSGPSARG-----TPRAPAHPSQPKPKGLQALRPPQ 284
Query: 1995 LTFIKE--SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSS-RCEELRAAPR 2051
+T ++ +P L LSS+ A +P A + P LPA SS C+ P
Sbjct: 285 VTPPRKDAAPAL----GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340
Query: 2052 QGPAPARQRPPAARPS-PGERPARRTTSESPSRL----------PVRAPAARPETVKRYA 2100
P+P+ PS P P++ TTS L P+ A P
Sbjct: 341 APPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400
Query: 2101 SLPHISVARRPDGAVPAAPASADAARR---------SSDGEPRPLPRVAAPGTTWRRIRD 2151
+LP + P + P +P + + + + P P P V AP +
Sbjct: 401 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP-----P 455
Query: 2152 EDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLET 2211
P +T P+ A P + P P PP A+P + S +P +
Sbjct: 456 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPP--------------ASPPMSPSATPPPQA 501
Query: 2212 REPPGAPAGGQLSLLGSDVDG-PSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARV 2270
P AP L L P+LA P+ A L FP SPS S +
Sbjct: 502 PPPLAAP---PLQLAKPPPQAPPALATPPLQA------LPSPPASFPGQAPFSPSASLPM 552
Query: 2271 PPFNYVP--SPMVVAATTDSAAEKAPAT 2296
P P +P V+AA PA+
Sbjct: 553 SPLATPPPQAPPVLAAPLLQVPPSPPAS 580
Score = 70.1 bits (170), Expect = 2e-11
Identities = 160/669 (23%), Positives = 210/669 (31%), Gaps = 169/669 (25%)
Query: 1349 AAVPARLRKVASALVPG-------RRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFS 1401
+A+ A R+ S PG RR+ + +P PAP+ T EG + S
Sbjct: 154 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT---EGPRKSVS 210
Query: 1402 SAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKN 1461
SA+ S R +P G QRP R S+ RS +RG
Sbjct: 211 SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT-----PLSSPARSGPSARGT--- 262
Query: 1462 RAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAA 1521
P APA KP +G AL+ +T P ++A S P A
Sbjct: 263 -----------PRAPAHPSQPKP---KGLQALRPPQVTPPRKDAAPALGPLSSS---PLA 305
Query: 1522 APTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSS 1581
P+P+ S P P + P APP PSL +PP S
Sbjct: 306 TPSPSAALQSQAPPTLPAT-PHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ 364
Query: 1582 SASSLSEP-----------EPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQ 1630
+ +SL P P P A P PA+ P + PSP A+
Sbjct: 365 ATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP-----LQAPPSPPAS----- 414
Query: 1631 RCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQ 1690
PP+S L P+A
Sbjct: 415 -----------PPLSPLATPSPQA------------------------------------ 427
Query: 1691 EGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARR 1750
N++ L QA + S + S + V + PP A +
Sbjct: 428 --PNALAVHLLQAPFSP-PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPS 484
Query: 1751 PEKRGAASVKTSGSPRSP---AGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKG 1807
P S + P++P A P P K P P L + +PSP P + P
Sbjct: 485 PPASPPMSPSATPPPQAPPPLAAP--PLQLAKPPPQAPPALATPPLQALPSP-PASFPGQ 541
Query: 1808 TP---------GPRATPRKVAPPCLAQP--------------AAPAKVPSPGQQRSRSLH 1844
P P ATP APP LA P AP + P+PG S S
Sbjct: 542 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVS-- 599
Query: 1845 RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPG 1904
P T LA PP S +P + L+ P + +S S P + G GP
Sbjct: 600 GPRLTLALAPGPPPPPSRSPSSTLS-GPDLAGHSSSATSTP--------EELRGYDSGPE 650
Query: 1905 ASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP-PPL----ARAVPEPGPRGRAGT 1959
P LA H S RGP PPL A P P P
Sbjct: 651 GGAAASPPPDAELAACHPAAWS------------RGPAPPLAFRGAPGAPLPWP-----P 693
Query: 1960 EAGPGARGG 1968
GPG+ G
Sbjct: 694 ATGPGSADG 702
Score = 61.2 bits (147), Expect = 1e-08
Identities = 110/460 (23%), Positives = 157/460 (34%), Gaps = 78/460 (16%)
Query: 838 AVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCR- 896
A A + LA I SA S SS +P P GR + P +
Sbjct: 49 AAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKN 108
Query: 897 ---GPEG--GRREAGSRAHPL----LRLKA--------AHASLSNDSLNSGSASDGYCPR 939
GP GR +R PL LR+ A A + +L++G+ D P
Sbjct: 109 TSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPT 168
Query: 940 EHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPA---REATSADARVRTIKLS 996
P P A SR G PRP+ P + PP R++ S+ + T + S
Sbjct: 169 PGT-PSPAMARRSRAAGTEVGLPRPA------PSARPRPPTEGPRKSVSSASEHSTTEPS 221
Query: 997 PTYQHVPLLEG-----ASRA---GAEPLAGPGIS-PGARKQAWLPADHLSKVPEKLAAAP 1047
P + P G ASR+ A PL+ P S P AR PA P+ L A
Sbjct: 222 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 281
Query: 1048 LSVASKALQKLAAQEGPLSLSRCSS------LSSLSSAGRPGPSEGGDLDDSDSSLEGLE 1101
+ + A GPLS S ++ L S + P L ++ L
Sbjct: 282 PPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA 341
Query: 1102 EAGPSEAELDSTWRAPGATS-------------------------LPVAIPAPRRNRGRG 1136
PS T +P AT P+A P P+
Sbjct: 342 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 401
Query: 1137 LGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIP--SEPCSGQGSGTIS 1194
L A PS + + + + ++ ++P P P S S +S
Sbjct: 402 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 461
Query: 1195 PSELPDS--------PGQTMPPSRSKTPPLAPAPQGPPEA 1226
PS P S P +PPS +PP++P+ PP+A
Sbjct: 462 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQA 501
Score = 38.9 bits (89), Expect = 0.059
Identities = 103/460 (22%), Positives = 150/460 (32%), Gaps = 46/460 (10%)
Query: 772 ASDSGCFDDDDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEK 831
A +G D P+ + A + A + L P + T R+ A +
Sbjct: 155 ALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASE 214
Query: 832 DTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSS-GDPGQEA-PREGRA 889
++ E + AA+ + + R SA SS S+ G P A P + +
Sbjct: 215 HSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKP 274
Query: 890 QSCSPCRGPE--GGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPL 947
+ R P+ R++A PL A S S + + P L C L
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL 334
Query: 948 AALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEG 1007
A P L P A PP++ TS + L T+ +P
Sbjct: 335 ATPLPLAPPSPSAPPSLQTL----PSPPATPPSQATTSLGSPT----LQATHSFLPSPPL 386
Query: 1008 ASRAGAEPLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSL 1067
+ A P A P ++ LP L A P AS L LA
Sbjct: 387 SPLATPPPQAPPALA--------LPP---------LQAPPSPPASPPLSPLATPSPQAPN 429
Query: 1068 SRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIP 1127
+ L + P P S PS+A P + P+ +P
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP-------PSLAAPPLQVP 482
Query: 1128 APRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSG 1187
P + ATP + + PL L++ + P ++PS P S
Sbjct: 483 -PSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP--LQALPSPPASF 538
Query: 1188 QGSGTISPS-ELPDSPGQTMPPSRSKTPPLAPAP--QGPP 1224
G SPS LP SP T PP + PP+ AP Q PP
Sbjct: 539 PGQAPFSPSASLPMSPLATPPP---QAPPVLAAPLLQVPP 575
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 92.8 bits (229), Expect = 3e-18
Identities = 166/719 (23%), Positives = 249/719 (34%), Gaps = 173/719 (24%)
Query: 1377 VPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSAR 1436
VP P P E E +P S ++T PR + + + + P+ R
Sbjct: 247 VPKPEPIPEPK------EPSPEKNSKKEKEKEKTR---PRSRSRSKSRSRTRSRSPSHTR 297
Query: 1437 QAMGHRHKAGGAG---RSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGAL 1493
HR ++ R + + R + + R P R P P + P R R
Sbjct: 298 PRRRHRSRSRSYSPRRRPSPRRRPSPRRRT----PPRRMPPPPRHRRSRSPVRRR---RR 350
Query: 1494 QSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQG----RKEAP 1549
S L+ + + + PP P +RTS+ PR R P R+ P
Sbjct: 351 SSASLSGSSSSS-----SSSRSRSPPKKPP----KRTSSPPRKTRRLSPSASPPRRRHRP 401
Query: 1550 APSKAAPAAPPP-ARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTK 1608
+P PA PPP R P+ P S + S +S V P VTK
Sbjct: 402 SP----PATPPPKTRHSPT-------PQQSNRTRKSRVS---------VSPGRTSGKVTK 441
Query: 1609 DPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRER 1668
G SP+P KPR L E
Sbjct: 442 HKGTEKRESPSPAP----------------------------KPRKVELSE--------- 464
Query: 1669 GEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGS 1728
EE G A+ DSV+ R Q +++SS+S S S
Sbjct: 465 SEEDKGGKMAA-ADSVQQR-------------RQYRRQNQQSSSDSGS----------SS 500
Query: 1729 TLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVL 1788
+ + + ++ GE+G R R + S S SPR PRG ++ +P P
Sbjct: 501 SSEDERPKRSHVKNGEVGRRR----RHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTR 556
Query: 1789 RGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAK 1848
R R+ PSPAP + + TP P R +PP + +P + P Q+R + P+
Sbjct: 557 RRRS----PSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRR----YSPSP 608
Query: 1849 TSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPV 1908
+ T S PP PP R A +PS + S P ++ PVT+
Sbjct: 609 PPKRRTASPPP----PPKRRA-SPSPPPKRRVSHSPPPKQRSSPVTKR------------ 651
Query: 1909 PKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGG 1968
++P+ L+ +H+ SP R R P P R P P PR + + P R G
Sbjct: 652 -RSPS---LSSKHRKGSSPSR----STREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRG 703
Query: 1969 RLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRR 2028
A SS S R + + +P ++ + S + + +
Sbjct: 704 ---------ASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVS 754
Query: 2029 GRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVR 2087
G P E P P+P + + P+ SP P ++ S +PS P R
Sbjct: 755 GSP------------EPAAKKPPAPPSPVQSQSPSTNWSPAV-PVKKAKSPTPSPSPPR 800
Score = 86.3 bits (212), Expect = 3e-16
Identities = 156/645 (24%), Positives = 226/645 (35%), Gaps = 99/645 (15%)
Query: 1519 PAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYS 1578
P +P R R R + R +PAP K P +PS+ E P
Sbjct: 182 PRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKT---PELPEPSVKVKE-PSVQE 237
Query: 1579 LSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALP 1638
+S++ L P+P P EP K+P P +S + E+ R S +
Sbjct: 238 ATSTSDILKVPKPEPIP-------EP---KEPSP---EKNSKKEKEKEKTRPRSRSRSKS 284
Query: 1639 RRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVT 1698
R R R R P TR P R R + R S R
Sbjct: 285 RSRT-----RSRSPSHTR----PRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPP 335
Query: 1699 WLHQAAAAT-----REASSESDSILSFVSGLSVGSTLQPPKHRKG--RQAEGEMGSARRP 1751
H+ + + R ++S S S S S S +PPK R+ SA P
Sbjct: 336 PRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPP 395
Query: 1752 EKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGP 1811
+R S + P++ P P+ + +T +V GRT V + + + +P P
Sbjct: 396 RRRHRPSPPATPPPKTRHSPT-PQQSNRTRKSRVSVSPGRTSGKV-TKHKGTEKRESPSP 453
Query: 1812 RATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQ-------------- 1857
PRKV + + Q+ R R + S + S
Sbjct: 454 APKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVK 513
Query: 1858 -----------PPRSATPPARLAKTPSSSSSQT--SPASQPLPRKRPPVTQAAGALPGPG 1904
P RSA+P R + +S + SP+ P R+R P + P
Sbjct: 514 NGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSP---SPAPPPRRR 570
Query: 1905 ASPVPKTPARTLLAKQHKTQRSPVRI-PFMQRPARRGPPPLAR-AVPEPGPRGRAGTEAG 1962
+P P RT + SP R P +QR PPP R A P P P+ RA
Sbjct: 571 RTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPP 630
Query: 1963 PGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQ 2022
P R +S RS SP +RR LSS S+P
Sbjct: 631 PKRR------------VSHSPPPKQRS-----------SPVTKRRSPSLSSKHRKGSSPS 667
Query: 2023 GASPRRGRPALPAVFLCSS---RCEELRAAP---RQGPAPARQRPPAARPSPGERPARRT 2076
S R R P S R + ++P R+G + + QR + PSP RP RR
Sbjct: 668 -RSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQS--PSPSTRPIRRV 724
Query: 2077 TSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPAS 2121
+ + +A + P++V+R +S +S + P P AP S
Sbjct: 725 SRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPS 769
Score = 72.4 bits (176), Expect = 5e-12
Identities = 160/698 (22%), Positives = 249/698 (35%), Gaps = 160/698 (22%)
Query: 1616 RDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGS 1675
R+ S SPR +R S PRRR S +RR + R+ R SR
Sbjct: 166 RERSRSPR------RRKSRSPSPRRRS--SPVRRERKRSHSRSPRHRTKSRSPSPAPEKK 217
Query: 1676 DRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQP-PK 1734
++ +L + + + +EA+S SD IL + +P P+
Sbjct: 218 EKTPELPEPSVKVKEP--------------SVQEATSTSD-ILKVPKPEPIPEPKEPSPE 262
Query: 1735 HRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVI 1794
++ E E RP R + ++ RSP+ +PR ++ R R+
Sbjct: 263 KNSKKEKEKEK---TRPRSRSRSKSRSRTRSRSPSHT-RPRRRHRS--------RSRSYS 310
Query: 1795 YVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELAT 1854
P+PR +P +P R PR++ PP + SP ++R RS A S ++
Sbjct: 311 PRRRPSPRRRP--SPRRRTPPRRMPPP-----PRHRRSRSPVRRRRRS---SASLSGSSS 360
Query: 1855 LSQPPRSATPPARLAKTPSSSSSQT---SPASQPLPRKRPPVTQAAGALPGPGASPVPKT 1911
S RS +PP + K SS +T SP++ P PR+R P P A+P PKT
Sbjct: 361 SSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP-PRRRHR--------PSPPATPPPKT 411
Query: 1912 PARTLLAKQHKTQRSPVRIPFMQRPAR----RGPPPLARAVPEPGPRGRAGTEAGPGARG 1967
+ ++T++S V + + + +G P P PR +E+ +G
Sbjct: 412 RHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEED-KG 470
Query: 1968 GRLGLV------------RVASALSSGSESSDRS-------------GFRRQLTFIKE-S 2001
G++ S+ SGS SS G RR+ + + S
Sbjct: 471 GKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSAS 530
Query: 2002 PGLRRRRSELSSAESAASAPQGASPRRGR---PALPAVFLCSSRCEELRAAP-----RQG 2053
P R+R+ E S +P RR R PA P + R P R+
Sbjct: 531 PSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRS 590
Query: 2054 PAPARQRPPAARP-SPGERPARRTTS---------------------------------- 2078
P+P R PP R SP P RRT S
Sbjct: 591 PSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTK 650
Query: 2079 -------------ESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAA 2125
SPSR A + +P KR++ P + P ++ +
Sbjct: 651 RRSPSLSSKHRKGSSPSRSTREARSPQPN--KRHSPSPRPRAPQTSSSPPPVRRGASSSP 708
Query: 2126 RRSSDGEP--RPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGP-P 2182
+R P RP+ RV+ R + I ++ P+ R S+ P P
Sbjct: 709 QRRQSPSPSTRPIRRVS---------RTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEP 759
Query: 2183 PRKTSDAVVQTEEVAAPKTN-SSTSPSLETREPPGAPA 2219
K A + +P TN S P + + P +P+
Sbjct: 760 AAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPS 797
Score = 50.1 bits (118), Expect = 3e-05
Identities = 134/567 (23%), Positives = 187/567 (32%), Gaps = 128/567 (22%)
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRSATPPARL------AKTPSSSSSQTSPASQP----- 1885
++RSRS R S PR + P R +++P + SP+ P
Sbjct: 166 RERSRSPRRRKSRSP------SPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEK 219
Query: 1886 ---LPR-----KRPPVTQAAGA-----LPGPGASPVPKTPARTLLAKQHKTQ-------- 1924
LP K P V +A +P P P PK P+ +K+ K +
Sbjct: 220 TPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSR 279
Query: 1925 -------RSPVRIPFMQRPAR------RGPPPLARAVP--EPGPRGRAGTE---AGPGAR 1966
R+ R P RP R R P R P P PR R P R
Sbjct: 280 SRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHR 339
Query: 1967 GGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASP 2026
R + R + +S S SS S R + K+ P +R+ ++ +P + P
Sbjct: 340 RSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPP----KRTSSPPRKTRRLSPSASPP 395
Query: 2027 -RRGRPALPAVFLCSSRCEELRAAPRQGPAPA---RQRPPAARPSPGERPARRTTSESPS 2082
RR RP+ PA R P P R R SPG + T +
Sbjct: 396 RRRHRPSPPAT---------PPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTE 446
Query: 2083 RLPVRAPAARPETVKRYAS--------LPHISVARRPDGAVPAAPASADAARRSSDGEPR 2134
+ +PA +P V+ S SV +R +S+D+ SS + R
Sbjct: 447 KRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER 506
Query: 2135 PL-----------------PRVAAP---------GTTWRRIRDEDVPHILRSTLPATA-L 2167
P R A+P RR R P R P+ A
Sbjct: 507 PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPP 566
Query: 2168 PLRGSTPEDAP----AGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQL 2223
P R TP P PPPR+ S + + + + S P T PP P
Sbjct: 567 PRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPK---- 622
Query: 2224 SLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFP--ASRH---GSPSRSAR-----VPPF 2273
+ P + S P V P +S+H SPSRS R P
Sbjct: 623 --RRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNK 680
Query: 2274 NYVPSPMVVAATTDSAAEKAPATASAT 2300
+ PSP A T S+ AS++
Sbjct: 681 RHSPSPRPRAPQTSSSPPPVRRGASSS 707
Score = 46.6 bits (109), Expect = 3e-04
Identities = 70/319 (21%), Positives = 107/319 (33%), Gaps = 45/319 (14%)
Query: 1354 RLRKVASALVPGRRALPVPVYMLV-----PAPAPAQEDDSCTDSAEGTPVNFSSAASLSD 1408
R RK ++ PGR + V + P+PAP ++S E ++A S+
Sbjct: 422 RTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQ 481
Query: 1409 ETLQGPPRDQPGGPAGRQRPTG--RPTSARQAMGH--RHKAGGAGRSAEQSRGAGKNRAG 1464
Q +G + RP + G R + RSA S +
Sbjct: 482 RRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETS 541
Query: 1465 LELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPT 1524
R PS P + P + TPT P P+
Sbjct: 542 PRGRRRRSPSPPPTRRRRSPSPAPPPRRRR-----TPTPP-------------PRRRTPS 583
Query: 1525 PTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQ------PSLIADETPPCYS 1578
P RR S PR ++ + +P P + + PPP + + P +PP
Sbjct: 584 PPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQ 643
Query: 1579 LSSSASSLSEPEPSEPPAVHPRGREPA----VTKDPGPGGGRDSSPSPRAAEEL-----L 1629
SS + P S + H +G P+ + P P SP PRA + +
Sbjct: 644 RSSPVTKRRSPSLS---SKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPV 700
Query: 1630 QRCISSALPRRRPPVSGLR 1648
+R SS+ RR+ P R
Sbjct: 701 RRGASSSPQRRQSPSPSTR 719
Score = 38.5 bits (88), Expect = 0.077
Identities = 83/375 (22%), Positives = 129/375 (34%), Gaps = 43/375 (11%)
Query: 866 TSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSND 925
TS+ D + +P E ++ + E R + SR+ R ++ S +
Sbjct: 239 TSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRP 298
Query: 926 SLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATS 985
S S Y PR P P + RR P P P R ++ R +S
Sbjct: 299 RRRHRSRSRSYSPRRR--PSPRRRPSPRRRTPPRRMPPPPRHRRS----RSPVRRRRRSS 352
Query: 986 ADARVRTIKLSPTYQHVPLLEGASRAGAEPLA----GPGISPGARKQAWLPADHLSKVPE 1041
A + S + P + R + P P SP R+ P + P
Sbjct: 353 ASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPP---ATPPP 409
Query: 1042 KLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLE 1101
K +P S +K S+S ++G+ +G + +S S
Sbjct: 410 KTRHSPTPQQSNRTRKSRV-----------SVSPGRTSGKVTKHKGTEKRESPSPAPKPR 458
Query: 1102 EAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSR 1161
+ SE+E D + A S+ +R + R + ++ S SS + E P
Sbjct: 459 KVELSESEEDKGGKMAAADSVQ------QRRQYRRQNQQSSSDSGSSSSSEDERPKRSHV 512
Query: 1162 CSSVSSLGSFESPSIASSIPS-----EPCSGQGSGTISPSELPD----SPGQTMPPSRSK 1212
+ SPS ++S PS + S +G SPS P SP PP R +
Sbjct: 513 KNGEVGRRRRHSPSRSAS-PSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRR 571
Query: 1213 T---PPLAPAPQGPP 1224
T PP P PP
Sbjct: 572 TPTPPPRRRTPSPPP 586
Score = 37.7 bits (86), Expect = 0.13
Identities = 60/282 (21%), Positives = 100/282 (35%), Gaps = 32/282 (11%)
Query: 2044 EELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLP-----VRAPAARPETVKR 2098
E R + +P R++ + P P RR S SR P R+P+ PE ++
Sbjct: 160 ESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEK 219
Query: 2099 YASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPH-- 2156
LP SV + + +V A +++D + EP P P+ +P ++ ++++
Sbjct: 220 TPELPEPSV-KVKEPSVQEATSTSDILKVPKP-EPIPEPKEPSPEKNSKKEKEKEKTRPR 277
Query: 2157 ---------ILRSTLPATALP-------LRGSTPEDAPA---GPPPRKTSDAVVQTEEVA 2197
RS P+ P R +P P+ P PR+ +
Sbjct: 278 SRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTP---PRRMPP 334
Query: 2198 APKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFP 2257
P+ S SP R + +G S S P ++ + ++ P
Sbjct: 335 PPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASP 394
Query: 2258 ASRHGSPSRSARVPP-FNYVPSPMVVAATTDSAAEKAPATAS 2298
R PS A PP + P+P T S +P S
Sbjct: 395 PRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTS 436
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 92.0 bits (227), Expect = 6e-18
Identities = 176/718 (24%), Positives = 233/718 (32%), Gaps = 122/718 (16%)
Query: 1552 SKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP- 1610
+KA AA PA P L+ P S P P P A+ G AV + P
Sbjct: 8 AKAGAAARTPAARAPGLLTPRPP---------GSPRPPPPVTPAALRVLGAAGAVGRKPL 58
Query: 1611 -----GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRR-------RKPRATRLD 1658
G GG +PRA R +S R PP R TR
Sbjct: 59 AERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG 118
Query: 1659 ERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIV------TWLHQAAAATREASS 1712
+G R EE +A++ + + A+ GA T A +R A +
Sbjct: 119 PLGQKGLRISAEETVARGKATE--APKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGT 176
Query: 1713 E---------------SDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAA 1757
E ++ VS S ST +P + R + G G +RP R +
Sbjct: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAG--GGLQRPASRSLS 234
Query: 1758 SVKTS------------GSPRSPAGPE--KPRGTQKTTPGVPAVLRGRTVI------YVP 1797
S T G+PR+PA P KP+G Q P P V R
Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRP--PQVTPPRKDAAPALGPLSS 292
Query: 1798 SPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELAT 1854
SP P P P A P +PP A + SP Q + S S LAT
Sbjct: 293 SPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 352
Query: 1855 LSQPPRSATPPARLAKTPSSSSSQTSPASQPL--PRKRPPVTQAAGALPGPGASPVPKTP 1912
PP A P L + S SP PL P + P A L P SP P P
Sbjct: 353 ---PPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAP-FSPPPSPP 408
Query: 1913 ARTLLAKQHKTQRSPVRIPFMQRPARRGPPPL-----ARAVPEPGPRGRAGTEAGPGARG 1967
+ + SP P Q P PPL A P P +A P
Sbjct: 409 VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA 468
Query: 1968 GRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPR 2027
L L + + L + P ++ S + S +P P
Sbjct: 469 PPLQLAKPPPQAPPALATP-------PLQALPSPPASFPGQAPFSPSASLPMSPLATPPP 521
Query: 2028 RGRPALPAVFL-------CSSRCEELRAAPRQGPAPARQRPP---AARPSPGERPAR--R 2075
+ P L A L S + R P GP + P A P P P+R
Sbjct: 522 QAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 581
Query: 2076 TTSESPSRLPVRAPA-ARPETVKRYASLPHISVARRPD------GAVPAAPASADA---A 2125
+T P + A + PE ++ Y S P A P PAA + A A
Sbjct: 582 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA 641
Query: 2126 RRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPP 2183
R + G P P P PG+ + + I + P +A P G+ GP P
Sbjct: 642 FRGAPGAPLPWPPATGPGSA------DGLCTIYETEGPESATPAPGA----LDPGPSP 689
Score = 76.6 bits (187), Expect = 3e-13
Identities = 152/614 (24%), Positives = 218/614 (35%), Gaps = 107/614 (17%)
Query: 1745 MGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLR--------GRTVI-- 1794
M + R K GAA+ + P P + P PA LR GR +
Sbjct: 1 MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60
Query: 1795 --------YVPSPAPRAQPKGTPGPRATPR-KVAPPCLAQPAAPAKVPSPGQQRSRSLHR 1845
+P APRA P T P A+ R + APP A+ +P V SPG+ +
Sbjct: 61 RAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPP--AKNTSPGPVSSPGRASGTTRPG 118
Query: 1846 PAKTSELATLSQ-----------PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVT 1894
P L ++ P RSA A+ +S + +P+ R R T
Sbjct: 119 PLGQKGLRISAEETVARGKATEAPKRSALSAG--ARRDTSGPTPGTPSPAMARRSRAAGT 176
Query: 1895 QAAGALPGPGASPVPKT--PARTL-LAKQHKT-------QRSPVRIPFMQRPARRGPPPL 1944
+ P P A P P T P +++ A +H T +R P +QRPA R
Sbjct: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 236
Query: 1945 ARAVPEP---GPRGRAGTEAGPG----ARGGRLGLVRVASALSSGSESSDRSGFRRQLTF 1997
A + P GP R GT P + L +R +++ G
Sbjct: 237 ATPLSSPARSGPSAR-GTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPL 295
Query: 1998 IKESPGLRRRRSELSSAES----AASAPQGASPRRGRPALPAV--FLCSSRCEELRAAPR 2051
SP S S ++ A+ P A+ G P L A FL S L P
Sbjct: 296 ATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 355
Query: 2052 QGP----APARQRPPAARPSPGERPARRTTSESPSRL---------------PVRAPAAR 2092
Q P P Q PP+ SP P + ++P+ L PV+AP +
Sbjct: 356 QAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSP 415
Query: 2093 PETVKRYASLPHISVA----RRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRR 2148
P + S S A P VP +P ++ S+ P+ P +AAP +
Sbjct: 416 PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAK 475
Query: 2149 IRDEDVPHILRSTLPATALPL-RGSTPEDAP------------AGPPPRKTSDAVVQTEE 2195
+ P + +T P ALP S P AP A PPP+ + V+
Sbjct: 476 PPPQAPPAL--ATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQ--APPVLAAPL 531
Query: 2196 VAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGP--SLAKAPISAPFVHEGLGVAV 2253
+ P + SP+L+ P P + V GP +LA AP P +
Sbjct: 532 LQVP-PSPPASPTLQAPRRPPTPGP------DTSVSGPRLTLALAPGPPPPPSRSPSSTL 584
Query: 2254 GGFPASRHGSPSRS 2267
G + H S + S
Sbjct: 585 SGPDLAGHSSSATS 598
Score = 75.9 bits (185), Expect = 4e-13
Identities = 144/552 (26%), Positives = 208/552 (37%), Gaps = 79/552 (14%)
Query: 1798 SPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQ 1857
+PA RA TP P +PR PP PAA + + G + L A AT+ +
Sbjct: 16 TPAARAPGLLTPRPPGSPR---PPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPE 72
Query: 1858 ------PPRSATPPA--RLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGAL-PGPGASPV 1908
P R++ PPA R + P + ++ P S P +A+G PGP
Sbjct: 73 SAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSP--------GRASGTTRPGPLGQKG 124
Query: 1909 PKTPARTLLAKQHKTQRSPVRIPFMQRPARR---GPPPLARAVPEPGPRGR---AGTEAG 1962
+ A +A+ T+ +P R + ARR GP P P P R AGTE G
Sbjct: 125 LRISAEETVARGKATE-APKRSA-LSAGARRDTSGPTP---GTPSPAMARRSRAAGTEVG 179
Query: 1963 -----PGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSE-LSSAES 2016
P AR R ++SS SE S GL+R S LSS+ +
Sbjct: 180 LPRPAPSARP-RPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 238
Query: 2017 AASAPQGASPR-RGRPALPA-------VFLCSSRCEELR-----AAPRQGP---APARQR 2060
S+P + P RG P PA L + R ++ AAP GP +P
Sbjct: 239 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 298
Query: 2061 PPAARPSPGERPARRTTSESPSRLPVRAPAARP----ETVKRYASLPHISVARRPDGAVP 2116
P+A PSP P+ +T P+ P +A + + + P +S P P
Sbjct: 299 SPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAP 358
Query: 2117 AAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTL-PATALPLRG---- 2171
A A S PL +A P + + H+L++ P + P++
Sbjct: 359 PALALPPLQAPPSPPASPPLSPLATPSP---QAPNALAVHLLQAPFSPPPSPPVQAPFSP 415
Query: 2172 -STPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP---AGGQLSLLG 2227
++P +P+ PP + ++ P +S S PP AP A L L
Sbjct: 416 PASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAK 475
Query: 2228 SDVDG-PSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVP--SPMVVAA 2284
P+LA P+ A L FP SPS S + P P +P V+AA
Sbjct: 476 PPPQAPPALATPPLQA------LPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAA 529
Query: 2285 TTDSAAEKAPAT 2296
PA+
Sbjct: 530 PLLQVPPSPPAS 541
Score = 64.7 bits (156), Expect = 1e-09
Identities = 101/391 (25%), Positives = 146/391 (37%), Gaps = 62/391 (15%)
Query: 884 PREGRAQSCSPCR----GPEG--GRREAGSRAHPL----LRLKA--------AHASLSND 925
P GR + P + GP GR +R PL LR+ A A +
Sbjct: 86 PASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRS 145
Query: 926 SLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPA---RE 982
+L++G+ D P P P A SR G PRP+ P + PP R+
Sbjct: 146 ALSAGARRDTSGPTPGT-PSPAMARRSRAAGTEVGLPRPA------PSARPRPPTEGPRK 198
Query: 983 ATSADARVRTIKLSPTYQHVPLLEG-----ASRA---GAEPLAGPGIS-PGARKQAWLPA 1033
+ S+ + T + SP + P G ASR+ A PL+ P S P AR PA
Sbjct: 199 SVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258
Query: 1034 DHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDS 1093
P+ L A + + A GPLS S L++ S + P PS L
Sbjct: 259 HPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS---SSPLATPSPSAPPSPSAPPSLQ-- 313
Query: 1094 DSSLEGLEEAGPSEAELD---STWRA-----PGATSLPVAIPAPRRNRGRGLGVEDATPS 1145
+L PS+A T +A P P+A P P+ L A PS
Sbjct: 314 --TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS 371
Query: 1146 SSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIP--SEPCSGQGSGTISPSELPDS-- 1201
+ + + + ++ ++P P P S S +SPS P S
Sbjct: 372 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 431
Query: 1202 ------PGQTMPPSRSKTPPLAPAPQGPPEA 1226
P +PPS +PP++P+ PP+A
Sbjct: 432 PPSLAAPPLQVPPSPPASPPMSPSATPPPQA 462
Score = 54.7 bits (130), Expect = 1e-06
Identities = 104/418 (24%), Positives = 149/418 (35%), Gaps = 63/418 (15%)
Query: 1890 RPPVTQAAGAL-PGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAV 1948
R P +A G L P P SP P P + + R P +R G + +
Sbjct: 15 RTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74
Query: 1949 PEPGPR--------GRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE 2000
P GP GR E P A+ G V + +SG+ G ++ L E
Sbjct: 75 PRAGPTRTSRPPASGRG--ERAPPAKNTSPGPVS-SPGRASGTTRPGPLG-QKGLRISAE 130
Query: 2001 SPGLRRRRSELS--SAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPAR 2058
R + +E SA SA + + P G P+ PA+ S PR P+ AR
Sbjct: 131 ETVARGKATEAPKRSALSAGARRDTSGPTPGTPS-PAMARRSRAAGTEVGLPRPAPS-AR 188
Query: 2059 QRPPAARPSPGERPARRTTSESPSRLPVRAPAA-----RPETVKRYASLPHISVARRPDG 2113
RPP P A ++ PS R P+A RP + +S +S P
Sbjct: 189 PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLS---SPAR 245
Query: 2114 AVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGST 2173
+ P+A + A S +P+ L + P T R +D L P ++ PL +T
Sbjct: 246 SGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR---KDAAPALG---PLSSSPL--AT 297
Query: 2174 PEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETR-EPPGAPAGGQLSLLGSD--- 2229
P +P+ PP + S PSL+T PP P + LGS
Sbjct: 298 P--SPSAPP-------------------SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQ 336
Query: 2230 -----VDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVV 2282
+ P L+ P L + P S SP S P P+ + V
Sbjct: 337 ATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAV 394
Score = 50.1 bits (118), Expect = 3e-05
Identities = 66/279 (23%), Positives = 99/279 (35%), Gaps = 31/279 (11%)
Query: 1349 AAVPARLRKVASALVPG-------RRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFS 1401
+A+ A R+ S PG RR+ + +P PAP+ T EG + S
Sbjct: 145 SALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT---EGPRKSVS 201
Query: 1402 SAASLSDETLQGPPRDQPGGPAGRQRPTGRP-TSARQAMGHRHKAGGAGRSAEQSRGAGK 1460
SA+ S R +P G QRP R +S+ + ++G + R ++
Sbjct: 202 SASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPS 261
Query: 1461 NRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPA 1520
L RPP + + P G L S L TP+ A S + P+
Sbjct: 262 QPKPKGLQALRPPQVTPPRKDAAPAL----GPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317
Query: 1521 AAPTPTHRRTSAI-------PRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADET 1573
TP + T+++ +F P P P A PP + PS
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPS------ 371
Query: 1574 PPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGP 1612
PP S S L+ P P P A+ + + P P
Sbjct: 372 PPA---SPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 407
Score = 43.9 bits (102), Expect = 0.002
Identities = 125/519 (24%), Positives = 177/519 (34%), Gaps = 74/519 (14%)
Query: 749 AAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAP------SSLAAAAATGEPASPAAL 802
AA A +KPL A+ G + AP +S A+ GE A PA
Sbjct: 49 AAGAVGRKPL---------AERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAK- 98
Query: 803 SLFLGSPFLQGQALARTPPTRRGGK----EAEKDTSGEAAVAAKAKAKLALAVARIDQLV 858
+ G G+A T P G K AE+ + A A ++ L+ R
Sbjct: 99 NTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARR----- 153
Query: 859 EDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAA 918
+ + + + S G E A S P R P G R++ S A + +
Sbjct: 154 DTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP-RPPTEGPRKSVSSASEHSTTEPS 212
Query: 919 HASLSNDSLNSG---SASDGYCPREHMLPCPLAALASRREDPRC----GQPRPSRLDLDL 971
A+ S G AS L P + S R PR QP+P L
Sbjct: 213 PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR 272
Query: 972 PGCQAEPPAREATSADARVRTIKLS-------PTYQHVPLLEGASRAGAEPLAGPGISPG 1024
P Q PP ++A A + + L+ P+ P L+ A P + S G
Sbjct: 273 PP-QVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLG 331
Query: 1025 A----RKQAWLPADHLS-------KVPEKLAAAPLSV-----ASKALQKLAAQEGPLSLS 1068
+ ++LP+ LS + P LA PL AS L LA +
Sbjct: 332 SPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNA 391
Query: 1069 RCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPA 1128
L + P P S PS+A P + P+ +P
Sbjct: 392 LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP-------PSLAAPPLQVP- 443
Query: 1129 PRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQ 1188
P + ATP + + PL L++ + P ++PS P S
Sbjct: 444 PSPPASPPMS-PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPP--LQALPSPPASFP 500
Query: 1189 GSGTISPS-ELPDSPGQTMPPSRSKTPPLAPAP--QGPP 1224
G SPS LP SP T PP + PP+ AP Q PP
Sbjct: 501 GQAPFSPSASLPMSPLATPPP---QAPPVLAAPLLQVPP 536
Score = 37.7 bits (86), Expect = 0.13
Identities = 108/455 (23%), Positives = 137/455 (30%), Gaps = 112/455 (24%)
Query: 1465 LELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPT 1524
L+ P PPS P S P + TP +A PP+ A
Sbjct: 397 LQAPFSPPPSPPVQAPFSPPASPPVSPS------ATPPSQA------------PPSLAAP 438
Query: 1525 PTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPP---ARTQPSL-IADETPPCYSLS 1580
P +P + P P P P A PP A+ P A TPP +L
Sbjct: 439 PLQ-----VPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493
Query: 1581 SSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR- 1639
S +S P P A P P T P +P AA L A P
Sbjct: 494 SPPASFPGQAPFSPSASLP--MSPLATPPP-------QAPPVLAAPLLQVPPSPPASPTL 544
Query: 1640 ---RRPPVSG--LRRRKPRAT--RLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEG 1692
RRPP G PR T P SR +G D A S
Sbjct: 545 QAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSS--------- 595
Query: 1693 ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPE 1752
A+S + + + SG G+ PP P+
Sbjct: 596 -----------------ATSTPEELRGYDSGPEGGAAASPP-----------------PD 621
Query: 1753 KRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPR 1812
AA + S R PA P RG PG P P P A G+
Sbjct: 622 AELAACHPAAWS-RGPAPPLAFRG----APGAPL------------PWPPATGPGSADGL 664
Query: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
T + P A PA A P P S + A + S+ P+ ARL + P
Sbjct: 665 CTIYETEGPESATPAPGALDPGPSPGTSGG--KAAAGAGAGASSRSPKQ----ARLGELP 718
Query: 1873 SSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASP 1907
+ + Q L + + A GA G G P
Sbjct: 719 LGALQ--ASVVQHLLSRTLLLAAAEGAAGGSGGGP 751
>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
Length = 3230
Score = 88.6 bits (218), Expect = 7e-17
Identities = 147/555 (26%), Positives = 196/555 (35%), Gaps = 106/555 (19%)
Query: 1790 GRTVIYVPSPAPRAQPKGTPG-----PRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLH 1844
G T + +PAPR G P P TP ++ P L AP P+ + + +H
Sbjct: 1320 GLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVH 1379
Query: 1845 RPAKTSELATLSQPPRSATPPARLAKTPSS----SSSQTSPAS--QPLPRKRPPVTQAAG 1898
P+ P SA+ P T SS SS PAS P+P P + +
Sbjct: 1380 SPS----------PEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSS 1429
Query: 1899 ALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP-------PPLARAVP-E 1950
+ P +S +P + TL A P+ P + GP PPLA VP
Sbjct: 1430 TVSVPLSSSLPISVPTTLPAPASAPLTIPISAPL--TVSASGPALLTSVTPPLAPVVPAA 1487
Query: 1951 PGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLT-FIKESPGLRRRRS 2009
PGP A + A P A LGL A + SS G L PGL +
Sbjct: 1488 PGPPSLAPSGASPSASALTLGL-----ATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVA 1542
Query: 2010 ELSS----AESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAP------------RQG 2053
S SA ++P ++P PA ++ +S + A P
Sbjct: 1543 PACSPVLVPASALASPFPSAPNPA-PAQASLLAPASSASQALATPLAPMAAPQTAILAPS 1601
Query: 2054 PAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYAS-LPHISVARRPD 2112
PAP P PSPG P + S + +PV AP++ P T AS +P + P
Sbjct: 1602 PAPPLAPLPVLAPSPGAAP---VLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPS 1658
Query: 2113 GAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGS 2172
PA P PLP A+ T + PA A L GS
Sbjct: 1659 STQTMLPAPV----------PSPLPSPASTQTL--------------ALAPALAPTLGGS 1694
Query: 2173 TPEDA-------PAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSL 2225
+P P GP P +T + V P S + PG P G +L
Sbjct: 1695 SPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLA--------PGPPLGPTQTL 1746
Query: 2226 LGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAAT 2285
S P LA A P L +A PAS S A V P+P+ T
Sbjct: 1747 --SLAPAPPLAPASPVGPAPAHTLTLA----PASSSASLLAPASVQTLTLSPAPV---PT 1797
Query: 2286 TDSAAEKAPATASAT 2300
AA + A A A+
Sbjct: 1798 LGPAAAQTLALAPAS 1812
Score = 83.2 bits (204), Expect = 3e-15
Identities = 163/646 (25%), Positives = 231/646 (35%), Gaps = 115/646 (17%)
Query: 1750 RPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYV------------- 1796
R +R V T+ P P K + + P VP GRTV+ V
Sbjct: 968 RLSRRVLLEVATAPDPPPRPKPVKMKVNRMLQP-VPKQ-EGRTVVVVNNPRAPLGPVPVR 1025
Query: 1797 PSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS----------PGQQRSRSLHR- 1845
P P P + TPGP + A PA P +P+ P Q S SL +
Sbjct: 1026 PPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQV 1085
Query: 1846 -PAKTSELATLSQPPRSA-----TPPA--RLAKTPSSSSSQ-----TSPASQPLPRKRPP 1892
P+ L+ S+PP TPPA RL+ P SS T P P
Sbjct: 1086 LPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPPGYTFPPAAAT 1145
Query: 1893 VTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSP----VRI----PFMQRPARR--GPP 1942
T A A P P + L+ R P V I QRP G
Sbjct: 1146 TTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSK 1205
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVR-----VASALSSGSESS--DRSGFRRQL 1995
PL + +G T G R +G R V +S+G + + +
Sbjct: 1206 PLTFQI-----QGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALI 1260
Query: 1996 TFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEEL--RAAPRQG 2053
+ +PG SS S AP G S +P + ++ ++ R APR G
Sbjct: 1261 QAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDG 1320
Query: 2054 PAPARQRPPAARPSPGERPA--RRTTSESPSRLP------VRAPAARPETVKRYASLPHI 2105
P PA RP PA + +P RLP RAP P V+ L H
Sbjct: 1321 LTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHS 1380
Query: 2106 ---SVARRPDGAVP---AAPASADAARRSSDGEPRPLPR---VAAP-GTTWRRIRDEDVP 2155
V+ GA P ++P ++ P P+P +A+P +T +P
Sbjct: 1381 PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLP 1440
Query: 2156 HILRSTLPATA-----LP--------------LRGSTPEDAPA-----GPPPRKTSDAVV 2191
+ +TLPA A +P L TP AP GPP S A
Sbjct: 1441 ISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGA-- 1498
Query: 2192 QTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGV 2251
+ +A +T+PSL + + PG P L+ S V G + AP +P + +
Sbjct: 1499 -SPSASALTLGLATAPSLSSSQTPGHPL--LLAPTSSHVPGLNSTVAPACSPVLVPASAL 1555
Query: 2252 AVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATA 2297
A FP++ + +P++++ + P S A T A AP TA
Sbjct: 1556 A-SPFPSAPNPAPAQASLLAP----ASSASQALATPLAPMAAPQTA 1596
Score = 58.5 bits (140), Expect = 7e-08
Identities = 176/778 (22%), Positives = 242/778 (31%), Gaps = 144/778 (18%)
Query: 1377 VPAPAPAQE-----DDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQP------------ 1419
VPAP PA + D G V+ ASL+ + +P
Sbjct: 1159 VPAPTPAPQRLILSPDMQARLPSGEVVSIGQLASLAQRPVANAGGSKPLTFQIQGNKLTL 1218
Query: 1420 GGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSA-PAD 1478
G RQ G+P ++ + H AGG Q +A P P S P+
Sbjct: 1219 TGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSS 1278
Query: 1479 KDGSKPGRT------RGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSA 1532
+ P T + ++ T + V D P AP P +S
Sbjct: 1279 TPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAP-RPPSSG 1337
Query: 1533 IPRAFTRERPQ---GRKEAPAPSKAAPAAPPPARTQP--SLIADETPPCYSLSSSASSLS 1587
+P A RP GR P A P P +P L+ +P + + A+ L+
Sbjct: 1338 LP-AVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLT 1396
Query: 1588 EPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGL 1647
P P+ P PA + P P +SP L + ++P P +
Sbjct: 1397 ISSPLHVPSSLPG---PASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASA 1453
Query: 1648 RRRKPRATRLD---ERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAA 1704
P + L PA + A A S+ A+++ L A
Sbjct: 1454 PLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAP 1513
Query: 1705 AATREASSESDSIL----SFVSGLSV------------GSTLQPPKHRKGRQAEGEMGSA 1748
+ + + +L S V GL+ S L P A + S
Sbjct: 1514 SLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQ-ASL 1572
Query: 1749 RRPEKRGAASVKTSGSPR----------SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPS 1798
P + ++ T +P SPA P P +PG VL +
Sbjct: 1573 LAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQ-----T 1627
Query: 1799 PAPRAQPKGTPG-------PRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSE 1851
P P P TPG P P V P Q PA VPSP L PA T
Sbjct: 1628 PVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSP-------LPSPASTQT 1680
Query: 1852 LATL---------SQP----------PRSATPPARLAKTPSSSSSQTSPASQPLPRKRPP 1892
LA S P P+ P L+ TP+SS T PA PP
Sbjct: 1681 LALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPT-PAQTLSLAPGPP 1739
Query: 1893 V--TQAAGALPGPG---ASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARA 1947
+ TQ P P ASPV PA TL + S + P + P P
Sbjct: 1740 LGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSAS-LLAPASVQTLTLSPAP---- 1794
Query: 1948 VPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRR 2007
VP GP P AS S S++S + S
Sbjct: 1795 VPTLGPAAAQTLALAP------------ASTQSPASQASS--------LVVSASGAAPLP 1834
Query: 2008 RSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAAR 2065
+ +S + P + R G P+ P+ A GP P RQ PP R
Sbjct: 1835 VTMVSRLPVSKDEPDTLTLRSGPPSPPST-----------ATSFGGPRPRRQPPPPPR 1881
Score = 57.0 bits (136), Expect = 2e-07
Identities = 177/749 (23%), Positives = 250/749 (33%), Gaps = 140/749 (18%)
Query: 1518 PPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPA-APPPARTQPSLIADETPPC 1576
PPA P P H A T P P A+ P R + L A
Sbjct: 2502 PPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASP 2561
Query: 1577 YSL------SSSASSLSEPEPSE--PPAVH--PRGRE--------PAVTKDPGPGGGRDS 1618
SL SS SSLS P + P AV P + P++T + G
Sbjct: 2562 ESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQE 2621
Query: 1619 SPSPRAAE----------ELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRER 1668
+P +AE E L C+S + PP + D R +E E
Sbjct: 2622 QEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEAD-RTSEELTEA 2680
Query: 1669 GEEAAGSDRASDLDSVEWRA--IQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSV 1726
+ ++ +L + E A A S A R S++ + + G
Sbjct: 2681 KTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVE-----IRGQGT 2735
Query: 1727 GSTLQPPKHRKGRQAEGEMGSA--------RRPEKRGAASVKTSGSPRSPAGPEKPRGTQ 1778
G QPP + R+ G + + RR ++RGAAS G + A P P
Sbjct: 2736 GRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRS 2795
Query: 1779 KTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQ 1838
+ P + G P A P P P +A + P G
Sbjct: 2796 MSGPESSPPIGG--------PCEAAPSSSLPTPPQQPF-IARRHIELGVTGGGSPENGDG 2846
Query: 1839 RSRSLHRPAKTSELATLSQPPRSATPPARLAK----TPSSSSSQTSPASQPLPRKRPPVT 1894
++ PA +PP+ PA + PSS+ + + P+P P
Sbjct: 2847 ALLAITPPAVKRRRG---RPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPG--PETL 2901
Query: 1895 QAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPR 1954
A + P P P+ L Q + +P+ P +R RRG PP AR +P PG
Sbjct: 2902 IVADPVLEPQLIPGPQP-----LGPQPVHRPNPLLSPVEKR--RRGRPPKARDLPIPGTI 2954
Query: 1955 GRAG-----TEAGPGARGGRLGLV-------------RVASALSSGSESSDRSG------ 1990
AG + P L + V + S S + G
Sbjct: 2955 SSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNP 3014
Query: 1991 ----------FRRQLTFIKESPGLRRRR-------SELSSAESAASAP--------QGAS 2025
R T + ES GL RRR SE SS++ S P A
Sbjct: 3015 PSPRPSQLPVLDRDSTSVLESCGLGRRRQPQGQGESEGSSSDEDGSRPLTRLARLRLEAE 3074
Query: 2026 PRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPAR-RTTSESP--- 2081
RGR + ++ + + ++L A GP PP +P R R R S P
Sbjct: 3075 GMRGRKSGGSMVVAVIQ-DDLDLAD-SGPGGLELTPPVVSLTPKLRSTRLRPGSLVPPLE 3132
Query: 2082 -SRLPVRAPAA----RPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEP--R 2134
+LP + A P KR P + P+G+V + A A DG P R
Sbjct: 3133 TEKLPRKRAGAPVGGSPGLAKRGRLQPPSPLG--PEGSVEESEAEASGEEEEGDGTPRRR 3190
Query: 2135 PLPRVAAPGTTWRRIRDEDVPHILRSTLP 2163
P PR GTT ++ ILRS+ P
Sbjct: 3191 PGPR-RLVGTT-----NQGDQRILRSSAP 3213
Score = 55.8 bits (133), Expect = 5e-07
Identities = 115/500 (23%), Positives = 163/500 (32%), Gaps = 70/500 (14%)
Query: 1735 HRKGRQAEG-EMGSARRPEKRGAASVKTSGSPRSPA-GPEKPRGTQKTTPGVPAVLRGRT 1792
HR+ ++A+ E R E+ A +T G+ +P + R T TTP
Sbjct: 2379 HRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRST--TTP---------- 2426
Query: 1793 VIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSP-GQQRSRSLHRPAKTSE 1851
PR P PR PR P A A PA VP P S P
Sbjct: 2427 --------PRCSPARERVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILP 2478
Query: 1852 LATL-SQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPP------VTQAAGALPGPG 1904
+ L S PP S PP SS + PA P P PP VT ++ L GP
Sbjct: 2479 VHILPSPPPPSQIPPC------SSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPP 2532
Query: 1905 ASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPG 1964
+ P+ S +P RP A+A+ P A +
Sbjct: 2533 SVPI---------------SASVTNLPLGLRPEAE---LCAQALASPESLELASVAS--- 2571
Query: 1965 ARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGA 2024
+ L LV L E S + L+ +P L + + + AP A
Sbjct: 2572 SETSSLSLVPPKDLLPVAVEILPVS--EKNLSLTPSAPSLTLEAGSIPNGQE-QEAPDSA 2628
Query: 2025 --SPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPS 2082
+ P + LC S L P Q P A + E +T + SP
Sbjct: 2629 EGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPE 2688
Query: 2083 RLP--VRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRV- 2139
+ V A A P T S P RP +A G+P P P+V
Sbjct: 2689 KPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQP-PGPKVL 2747
Query: 2140 -AAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAA 2198
PG + ++++ R A + + G + A G P ++ + +
Sbjct: 2748 RKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGG 2807
Query: 2199 PKTNSSTSPSLETREPPGAP 2218
P +PS PP P
Sbjct: 2808 P---CEAAPSSSLPTPPQQP 2824
Score = 51.2 bits (121), Expect = 1e-05
Identities = 80/302 (26%), Positives = 105/302 (34%), Gaps = 26/302 (8%)
Query: 1755 GAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRAT 1814
GAA V S ++P P T T+ + + T + PS P P P +
Sbjct: 1617 GAAPVLASS--QTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPS 1674
Query: 1815 PRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
P L APA P+ G P++T L T + P+ P L+ TP+S
Sbjct: 1675 PASTQTLAL----APALAPTLGGS------SPSQTLSLGTGN--PQGPFPTQTLSLTPAS 1722
Query: 1875 SSSQTSPASQPLPRKRPPV--TQAAGALPGP---GASPVPKTPARTLLAKQHKTQRSPVR 1929
S T PA PP+ TQ P P ASPV PA TL + S +
Sbjct: 1723 SLVPT-PAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSAS-LL 1780
Query: 1930 IPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRS 1989
P + P P VP GP P + +SG+ +
Sbjct: 1781 APASVQTLTLSPAP----VPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVT 1836
Query: 1990 GFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAA 2049
R L K+ P RS S S A++ G PRR P P EE R
Sbjct: 1837 MVSR-LPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKR 1895
Query: 2050 PR 2051
R
Sbjct: 1896 QR 1897
Score = 47.4 bits (111), Expect = 2e-04
Identities = 139/664 (20%), Positives = 212/664 (31%), Gaps = 134/664 (20%)
Query: 1647 LRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAA 1706
L + K RL + EG E + G+ + S + +A + + L A A
Sbjct: 2346 LDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHRRSKKAKAPERPGTRVSERLRGARAE 2405
Query: 1707 TREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPR 1766
T+ A+ +S ST PP+ R+ RP A + + P
Sbjct: 2406 TQGANHTP-----VISAHQTRSTTTPPRCSPARERVPRPAPRPRPTPASAPAAIPALVPV 2460
Query: 1767 SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQ------PKGTPGPRATPRKVAP 1820
+ P + P +L V +PSP P +Q P TP P TP
Sbjct: 2461 PVSAP-----VPISAPNPITIL---PVHILPSPPPPSQIPPCSSPACTPPPACTPPPAHT 2512
Query: 1821 P-----CLAQPAAPAKVPSPGQQRSRSL-HRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
P CL P++P + P S S+ + P A L ++ LA SS
Sbjct: 2513 PPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCAQALASPESLELASVASS 2572
Query: 1875 SSSQTS---------------PASQP---LPRKRPPVTQAAGALPGPGASPVPKTPARTL 1916
+S S P S+ L P +T AG++P P + T
Sbjct: 2573 ETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTT 2632
Query: 1917 LAKQHKTQRSPVRIPFMQRPARRGPPPLARAVP--EPGPRGR-------AGTEAGPGARG 1967
L + + P+ + + PP A P EP R A T +
Sbjct: 2633 LTVLPEGEELPLCVS--ESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKP 2690
Query: 1968 GRLGLVRVASALSSGSESSDRSGFR----------------------------------- 1992
L VA+ +S S +S G
Sbjct: 2691 QELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKL 2750
Query: 1993 --RQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAP 2050
R +T ++E +RRRR + +A + S G P++ ++ + P
Sbjct: 2751 PGRLVTVVEEKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSM-----------SGP 2799
Query: 2051 RQGP---APARQRPPAARPSPGERP--ARR------TTSESPSRLPVRAPAARPETVKRY 2099
P P P ++ P+P ++P ARR T SP A P VKR
Sbjct: 2800 ESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRR 2859
Query: 2100 ASLP---HISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPH 2156
P + S A G A ++ +D P P + A P
Sbjct: 2860 RGRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPGPETLIVADPVL--------EPQ 2911
Query: 2157 ILRSTLPATALPLRGSTPEDAPA-----GPPPRKTSDAVVQTEEVAAPKTNSSTSPSLET 2211
++ P P+ P +P G PP K D + +A NS + T
Sbjct: 2912 LIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPP-KARDLPIPGTISSAGDGNSES----RT 2966
Query: 2212 REPP 2215
+ PP
Sbjct: 2967 QPPP 2970
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/290 (23%), Positives = 104/290 (35%), Gaps = 58/290 (20%)
Query: 957 PRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPL 1016
P P S L L L A +S+ + L+PT HVP L P
Sbjct: 1495 PSGASPSASALTLGLA------TAPSLSSSQTPGHPLLLAPTSSHVPGLNST----VAPA 1544
Query: 1017 AGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSL 1076
P + P + + P+ + P A+ L+ AS A Q LA P++ + + L+
Sbjct: 1545 CSPVLVPASALASPFPS---APNPAPAQASLLAPASSASQALATPLAPMAAPQTAILA-- 1599
Query: 1077 SSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGA------TSLPVAIPAPR 1130
P P+ P A L +PGA + PV + AP
Sbjct: 1600 -----PSPA-------------------PPLAPLPVLAPSPGAAPVLASSQTPVPVMAPS 1635
Query: 1131 RNRGRGLGVEDATPS-------SSSENYVQ---ETPLVLSRCSSVSSLGSFESPSIASSI 1180
G L P+ SS++ + +PL + +L +P++ S
Sbjct: 1636 STPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSS 1695
Query: 1181 PSEPCS---GQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEAT 1227
PS+ S G G L +P ++ P+ ++T LAP P P T
Sbjct: 1696 PSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQT 1745
Score = 44.3 bits (103), Expect = 0.001
Identities = 92/354 (25%), Positives = 124/354 (35%), Gaps = 74/354 (20%)
Query: 1327 PTGSRPRGAADQELELLRECLGAAVPARLRKVASA------LVPGRRALPVPVYML---- 1376
P G RP E EL + L + L VAS+ LVP + LPV V +L
Sbjct: 2544 PLGLRP------EAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSE 2597
Query: 1377 ------VPAPA--------PAQEDDSCTDSAEGT-----------PVNFSSAASL----- 1406
AP+ P ++ DSAEGT P+ S + L
Sbjct: 2598 KNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPS 2657
Query: 1407 --SDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAG 1464
SDE LQ P + T PTS+ + A A S S +
Sbjct: 2658 AASDEPLQEPLEADRTSEELTEAKT--PTSSPEKPQELVTAEVAAPSTSSSATSSPEGPS 2715
Query: 1465 LELPLGRPPSAPADKDG---SKPGRTRGDGALQSL--CLTTPTEEAVYCFYGNDSDEEPP 1519
P R SA + G +PG+ G L+ L L T EE +
Sbjct: 2716 PARPPRRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKE--LVRRRRQQRGA 2773
Query: 1520 AAAPTPTHRRTSAIPRAFTRERPQGRKEAP---APSKAAPAAPPPARTQPSLIADETPPC 1576
A+ P TSA P + + G + +P P +AAP++ P Q IA
Sbjct: 2774 ASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARR---- 2829
Query: 1577 YSLSSSASSLSEPEPSE-------PPAV-HPRGREPAVTKDPGPGG-GRDSSPS 1621
+ + PE + PPAV RGR P + P G G D +PS
Sbjct: 2830 -HIELGVTGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPS 2882
Score = 34.3 bits (77), Expect = 1.5
Identities = 126/547 (23%), Positives = 168/547 (30%), Gaps = 77/547 (14%)
Query: 1116 APGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSS-LGSFESP 1174
APGA L ++ P L V + P +S +P+ + S ++S + S S
Sbjct: 1389 APGAAPLTISSP---------LHVPSSLPGPAS------SPMPIPNSSPLASPVSSTVSV 1433
Query: 1175 SIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPS-----RSKTPPLAP---APQGPPE- 1225
++SS+P + + +P +P S T+ S S TPPLAP A GPP
Sbjct: 1434 PLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSL 1493
Query: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
A + S + L A + P + P N + A + S +
Sbjct: 1494 APSGASPSASALTLGLATAPSLSSSQTPGH-PLLLAPTSSHVPGLNSTVAPACSPVL--- 1549
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
V L S P A A PA + S+ + +
Sbjct: 1550 ------VPASALASPFPSAPNPAPAQASLLA--------PASSASQALATPLAPMAAPQT 1595
Query: 1346 CLGAAVPARLRKVASALVPGRRALPVPVYMLVPAP--APAQEDDSCTDSAEGTPVNFSSA 1403
+ A PA L P A PV P P AP+ + SA P
Sbjct: 1596 AILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVL 1655
Query: 1404 ASLSDETLQGPPRDQP-GGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNR 1462
A S +T+ P P PA Q P A GG+ S S G G +
Sbjct: 1656 APSSTQTMLPAPVPSPLPSPASTQTLALAPALA-------PTLGGSSPSQTLSLGTGNPQ 1708
Query: 1463 AGLE------LPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDE 1516
P PA PG G SL P A
Sbjct: 1709 GPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPA---------SP 1759
Query: 1517 EPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPC 1576
PA A T T S+ Q +PAP P A+T A P
Sbjct: 1760 VGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAP--VPTLGPAAAQTLALAPASTQSPA 1817
Query: 1577 YSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSA 1636
SS S S P V R P +P R PSP +
Sbjct: 1818 SQASSLVVSASGAAPLPVTMV---SRLPVSKDEPDTLTLRSGPPSPPST----ATSFGGP 1870
Query: 1637 LPRRRPP 1643
PRR+PP
Sbjct: 1871 RPRRQPP 1877
Score = 32.7 bits (73), Expect = 4.2
Identities = 75/298 (25%), Positives = 112/298 (37%), Gaps = 58/298 (19%)
Query: 944 PCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVP 1003
P P++ L S P P+ L L L Q P T V VP
Sbjct: 1269 PTPVSVLPSSTPSTT---PAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVP 1325
Query: 1004 LLEGASRAGAEPLAG-----PGISPG-------ARKQAWLPADHLSKVPEKLAAAPLSVA 1051
L A R + L P ++PG +A +P L + KL +P
Sbjct: 1326 PLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSP---- 1381
Query: 1052 SKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELD 1111
S + A PL++S S L SS PGP+ SS + + P + +
Sbjct: 1382 SPEVSASAPGAAPLTIS--SPLHVPSSL--PGPA---------SSPMPIPNSSPLASPVS 1428
Query: 1112 STWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSF 1171
ST P ++SLP+++P P+S+ PL +S +S +L +
Sbjct: 1429 STVSVPLSSSLPISVPTTL-----------PAPASAPLTIPISAPLTVS--ASGPALLTS 1475
Query: 1172 ESPSIASSIPSEPCSGQGSGTISPSELPDSP-----GQTMPP--SRSKTP--PLAPAP 1220
+P +A +P+ P G +++PS S G P S S+TP PL AP
Sbjct: 1476 VTPPLAPVVPAAP----GPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAP 1529
Score = 31.6 bits (70), Expect = 9.4
Identities = 52/241 (21%), Positives = 93/241 (38%), Gaps = 26/241 (10%)
Query: 2055 APARQRPPAARPSPGER-PARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDG 2113
+PA PPA P P P +T +PS + P + P + AS+ ++ + RP+
Sbjct: 2496 SPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPIS----ASVTNLPLGLRPEA 2551
Query: 2114 AVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGST 2173
+ A+ + E L VA+ T+ + VP + LP+
Sbjct: 2552 EL--------CAQALASPESLELASVASSETSSLSL----VPPKDLLPVAVEILPVSEKN 2599
Query: 2174 PEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGP 2233
P+ P + ++ +E AP + T+ ++ P G +L L S+ +G
Sbjct: 2600 LSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTV-------LPEGEELPLCVSESNGL 2652
Query: 2234 SLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKA 2293
L + S + E L + +P+ S P + + V A +T S+A +
Sbjct: 2653 ELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKP--QELVTAEVAAPSTSSSATSS 2710
Query: 2294 P 2294
P
Sbjct: 2711 P 2711
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 87.0 bits (214), Expect = 2e-16
Identities = 195/867 (22%), Positives = 313/867 (36%), Gaps = 115/867 (13%)
Query: 1482 SKPGRTRG---DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
S+ GR R D ALQ+ T + + ++ +EE A T R S
Sbjct: 57 SELGRKRKAEEDAALQAK--KTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 1539 RERPQGRKE-----APAPSKAAPAAPPPA--RTQPSLIADETPPCYSLSSSASSL---SE 1588
+ P KE K + P PA +T +L++ ++P + S+ ++L +E
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 1589 PEPSEP-------PAVHPRGREPAVTKDPGPGGGR---DSSPSPRAAEELLQRCISSALP 1638
E S P P + G+ + ++D + PS + A+ + P
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 1639 RRR--PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI 1696
R+ P + P+ PA+ +++ EE+ S+ S+ +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE------------- 281
Query: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA 1756
+A A TR S+ IL V + P K G+ A + P K GA
Sbjct: 282 -----EAPAGTRSQVKASEKILQ------VRAASAPAKGTPGKGA-----TPAPPGKAGA 325
Query: 1757 ASVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPR 1812
+ +T +G P S + E+ +++ TP A+L+ + + P K +P
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
A P APP PA ++ S+S + + E A P P R A P
Sbjct: 386 AAP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 1873 SSSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV- 1928
+ S + A P PRK P Q +S R LA + Q P+
Sbjct: 443 AKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
+ P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD
Sbjct: 502 KSPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDS 555
Query: 1989 SGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSR 2042
S +P + + A+ +S +G + G A+ P SS
Sbjct: 556 SDGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 2043 CEELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
A + PA A+ +P P P + T+ S PVR P
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA--- 669
Query: 2100 ASLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDED 2153
A P G+ PA PA ++ SD E G + +
Sbjct: 670 ------GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKS 717
Query: 2154 VPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETRE 2213
V L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 718 VGKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEE 773
Query: 2214 PPGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPP 2272
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 774 AAASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PP 830
Query: 2273 FNYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 831 VRNPQNSTVLARGPASVPSVGKAVATA 857
Score = 78.2 bits (191), Expect = 9e-14
Identities = 269/1237 (21%), Positives = 413/1237 (33%), Gaps = 241/1237 (19%)
Query: 1106 SEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSV 1165
SE E + + A GA + P + A G+ + T SSS E V+ P V
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSA-----GQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
Query: 1166 SSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPE 1225
SS+ + ESP+ ++ P G+ G ++ P G +PP++ A P+ E
Sbjct: 226 SSVSTKESPARKAA----PAPGK-VGDVT----PQVKGGALPPAKR-----AKKPEEESE 271
Query: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
+++ + SE +A + + K E + SA A
Sbjct: 272 SSEEGSE---------------------SEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
A P G AG + E+ + + S +++E +
Sbjct: 311 PG----------KGATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKA 358
Query: 1346 CLGAAVPARLRKVASALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNF 1400
L A + +V +A P + A P P PA A AQ DS
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS-------- 410
Query: 1401 SSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GR 1450
S++ SD + P + +P G A + R P G K G A G+
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 1451 SAEQSRGAGKN-----------RAGLELPLGRPPSA-PADKDGSKPGRTRGDGALQSLCL 1498
E SR + + A PLG+ P PA G P +G G + +
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP-LGKGAGPVPPGKV 529
Query: 1499 TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAA 1558
T A + DS+ ++ + +A+ A +E+ G P+ ++PA
Sbjct: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA--QEKSLGNILQAKPT-SSPAK 586
Query: 1559 PPPARTQPSL--IADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGR 1616
PP + P + E P S SS SS S P A+ +PA+ K P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL-KIPQTKACP 645
Query: 1617 DSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSD 1676
+ + +A+ R + + PR+ + P +RPAE S EE+ +
Sbjct: 646 KKTNTTASAKVAPVR-VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEE 703
Query: 1677 RASDLDSVEWRAIQEG-ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKH 1735
+ L A+ G A S+ L AA+ S + G G T+ K
Sbjct: 704 EKTGL------AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG-KTGPTVTQVKA 756
Query: 1736 RKGRQAEGEMGSARRPEKRGA-----ASVKTSGSPRSPAGPEKP--RGT-----QKTTPG 1783
K +E + E + SVK + + +PA P +GT + T
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRS 1840
A R + + P P+ GP + P + VA AQ P +
Sbjct: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ-------TGPEEDSG 869
Query: 1841 RSLHRPAKTSELATLSQ-PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA 1899
S E TL+Q P T R A P+ S + A P P K P AG
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGK 928
Query: 1900 LPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGT 1959
G+S + S P A+ PPL P P G A T
Sbjct: 929 QDDSGSS--------------SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 1960 EA-GPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAA 2018
A A R ++A SS SES D +PG+R + +A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL---TPGIRTNVVTMPTAHP-- 1029
Query: 2019 SAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPG---ERPARR 2075
R AP+ A A ++R S G E PA +
Sbjct: 1030 ----------------------------RIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Query: 2076 TTSESPSRLPVRAPAARPETVK-----RYASLPHISVARRPDGAVPAAPASADAARRSSD 2130
S + LP +P + K R LP + A + AP S+D + SSD
Sbjct: 1062 VDS-AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATK-------APESSDDSEDSSD 1113
Query: 2131 GEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAV 2190
++ G+ D + P +G+ GP P +T V
Sbjct: 1114 ---------SSSGSE----EDGEGP--------------QGAKSAHTLVGPTPSRTETLV 1146
Query: 2191 VQT------EEVAAPK------------TNSSTSPSLETREPPGAPAGGQLSLLGSDVDG 2232
+T ++V AP T +++ S T + +P+ D DG
Sbjct: 1147 EETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDG 1206
Query: 2233 PSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSAR 2269
AK +A L GG A+ +P +S +
Sbjct: 1207 KQEAKPQQAAGM----LSPKTGGKEAASGTTPQKSRK 1239
Score = 75.9 bits (185), Expect = 4e-13
Identities = 235/1162 (20%), Positives = 400/1162 (34%), Gaps = 208/1162 (17%)
Query: 758 LPPLRHLDGLAQDY-ASDSGCFDDDDAPSSL---------------AAAAATGEPASPAA 801
LPP + ++ +S+ G +++AP+ A+A A G P A
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA- 315
Query: 802 LSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDI 861
+P G+A A T+ G E + ++S E + ++ + A A+ +
Sbjct: 316 ------TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK------ 363
Query: 862 SALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHAS 921
S S ++ P +E+PR+G A + GP + +AG R ++ S
Sbjct: 364 ----ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEES 417
Query: 922 LSNDSLNSGSASDGYCPREHMLPCP--------LAALASRREDPRCGQPRPSRLDLDLPG 973
S + + + G P+ P A R+ P Q + + + D
Sbjct: 418 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 974 CQAEPPA-REATSA--DARVRTIKLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQA 1029
E + REA +A A+V+ + SP ++ AS G PL G G P +
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 1030 WLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSE 1086
P+ + K E ++ + + ++ P SL SS + P +
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 1087 GG----------DLDDSDSSLEGLEEAGPSEA-------------ELDSTWRAPGATS-- 1121
G +D+S+SS E + A EA ++ T P T+
Sbjct: 592 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
Query: 1122 -------LPVAIPAPRR--------------NRGRGLGVEDATPSSSSENYVQETPLVLS 1160
+ V APR+ G ED++ S S++ ++T L ++
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
Query: 1161 RCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAP 1220
S+G A+S+P + GQG+ + P + + Q + + + +
Sbjct: 712 -VGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEE 768
Query: 1221 QGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCAS---- 1276
EA Q ++ VK+ A+ P+ A S + T+ P + + A+
Sbjct: 769 SDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 1277 -SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGA 1335
S S + Q L P++ P G A + + GP
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA-------QAQTGPEEDSGSSEEE 874
Query: 1336 ADQELELLRECLGAAVPA-RLRKVASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDS 1388
+D E E E L P+ + ++ +AL P + A P P P+ A A ++DDS
Sbjct: 875 SDSEEE--AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 1389 CTDSAEGTPVNFSSAASLSDETLQGP-----PRDQPGGPAGRQRPTGRPTSARQAMGHRH 1443
+ S E + AA S + ++ P P P GPA ++ R+A
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1444 KAGGAGRSAE--------QSRGAGKNRAGLELPLGRPPSAPAD--------------KDG 1481
A + +E Q G + +P P AP DG
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 1482 SKP--GRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTR 1539
K T+ D A+ +L T+P +V N + T S+ +
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112
Query: 1540 ERPQGRK---EAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPA 1596
+ G + E P +K+A P ++ + +ET + SS + P S
Sbjct: 1113 DSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEET----AAESSEDDVVAPSQSLLSG 1168
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
G PA ++ DSSPS +SS L + P G + KP+
Sbjct: 1169 YMTPGLTPANSQASKATPKLDSSPS-----------VSSTLAAKDDP-DGKQEAKPQQAA 1216
Query: 1657 LDERPAEGSRE-----------RGEEAAGSDRASDLDSVEWRAIQEGANSIV---TWLHQ 1702
P G +E + ++ AG+ +AS L A+Q + W
Sbjct: 1217 GMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTL------ALQSNITQCLLGQPWPLN 1270
Query: 1703 AAAATREASSESDSILSFVSGLSVGSTLQPPKHRKG-----RQAEGEMGSARRPEKRGAA 1757
A +L V +T + RKG R+ G+ +AR P +
Sbjct: 1271 EAQVQASVVKVLTELLEQERKKVVDTTKE--SSRKGWESRKRKLSGDQPAARTPRSKKKK 1328
Query: 1758 SVKTSGSPRSPAGPEKPRGTQK 1779
+ + PEK T K
Sbjct: 1329 KLGAGEGGEASVSPEKTSTTSK 1350
Score = 68.2 bits (165), Expect = 9e-11
Identities = 193/958 (20%), Positives = 332/958 (34%), Gaps = 119/958 (12%)
Query: 1379 APAPAQEDDSCTDSA--EGTP------VNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG 1430
A + +++ S +D EG P V SS ++ + P G Q G
Sbjct: 196 ADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG 255
Query: 1431 RPTSARQAMGHRHKAGGA--GRSAEQSRGAGKN---RAGLELPLGRPPSAPADKD---GS 1482
A++A ++ + G +E+ AG +A ++ R SAPA G+
Sbjct: 256 ALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 1483 KPGRTRGDGALQSLCLTTPTEEAVYCFY--GNDSDEEPPAAAPTPTHRRTSAIPRAFTRE 1540
P GA+ S EE +DS+EE PAA A+ +A
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA---------KALLQAKASG 366
Query: 1541 RPQGRKEAPAPSKAAP---AAP-PPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPA 1596
+ A AP+K +P AAP PP +T P++ + S S+S S+ E P
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
P G+ P V RAA + P + P G PR T
Sbjct: 427 AKPSGKAPQV----------------RAA----------SAPAKESPRKGAAPAPPRKTG 460
Query: 1657 LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDS 1716
PA + G++ S R+S +S R N+ + + AS+
Sbjct: 461 ----PAAAQVQVGKQEEDS-RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG 515
Query: 1717 ILSFVSGLSVGSTLQP--PKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
L +G + P P + G+ E S+ V T+ +P EK
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ----EKS 571
Query: 1775 RGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS 1834
G +L+ + P+ +P P GP A K P ++ S
Sbjct: 572 LGN---------ILQAK-----PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 1835 PGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPA--SQPLPRKRPP 1892
+ + + A+ L P A P KT +++S++ +P PRK
Sbjct: 618 ADSEEAPAAMTAAQAKP--ALKIPQTKACPK----KTNTTASAKVAPVRVGTQAPRKAGT 671
Query: 1893 VTQAAGALPG-PGASPVPKTPARTLLAKQHKTQRSPVRIPFMQ-RPARRGPPPLARAVPE 1950
T AG+ P G + P + + + +++ + + Q + +G A +VP
Sbjct: 672 ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPV 731
Query: 1951 PGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSE 2010
G G+ PG G + V+ S S + + + +++ +++
Sbjct: 732 KGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 2011 LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP--APARQRPPAARPSP 2068
+ A + A + +G G+ + A R P + P + R PA+ PS
Sbjct: 792 ANPAAARAPSAKGTISAPGK-VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 2069 GERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRS 2128
G+ A +++ + ++ + +L + + + A + ++ R+
Sbjct: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 2129 SDGEP--RPLPRVAAPG-------TTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPA 2179
+ P + P A G ++ D + P + S PL P +PA
Sbjct: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA-QVIKPPLIFVDPNRSPA 969
Query: 2180 GPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAP 2239
GP T A +++ S S E+ + PA L+ P +
Sbjct: 970 GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT--------PGIRTNV 1021
Query: 2240 ISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATA 2297
++ P H + AS S S+R+ P A DSA PAT+
Sbjct: 1022 VTMPTAHPRIAPKASMAGAS---SSKESSRISDGKKQEGP---ATQVDSAVGTLPATS 1073
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 87.0 bits (214), Expect = 2e-16
Identities = 195/867 (22%), Positives = 313/867 (36%), Gaps = 115/867 (13%)
Query: 1482 SKPGRTRG---DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
S+ GR R D ALQ+ T + + ++ +EE A T R S
Sbjct: 57 SELGRKRKAEEDAALQAK--KTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 1539 RERPQGRKE-----APAPSKAAPAAPPPA--RTQPSLIADETPPCYSLSSSASSL---SE 1588
+ P KE K + P PA +T +L++ ++P + S+ ++L +E
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 1589 PEPSEP-------PAVHPRGREPAVTKDPGPGGGR---DSSPSPRAAEELLQRCISSALP 1638
E S P P + G+ + ++D + PS + A+ + P
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 1639 RRR--PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI 1696
R+ P + P+ PA+ +++ EE+ S+ S+ +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE------------- 281
Query: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA 1756
+A A TR S+ IL V + P K G+ A + P K GA
Sbjct: 282 -----EAPAGTRSQVKASEKILQ------VRAASAPAKGTPGKGA-----TPAPPGKAGA 325
Query: 1757 ASVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPR 1812
+ +T +G P S + E+ +++ TP A+L+ + + P K +P
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
A P APP PA ++ S+S + + E A P P R A P
Sbjct: 386 AAP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 1873 SSSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV- 1928
+ S + A P PRK P Q +S R LA + Q P+
Sbjct: 443 AKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
+ P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD
Sbjct: 502 KSPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDS 555
Query: 1989 SGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSR 2042
S +P + + A+ +S +G + G A+ P SS
Sbjct: 556 SDGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 2043 CEELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
A + PA A+ +P P P + T+ S PVR P
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA--- 669
Query: 2100 ASLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDED 2153
A P G+ PA PA ++ SD E G + +
Sbjct: 670 ------GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKS 717
Query: 2154 VPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETRE 2213
V L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 718 VGKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEE 773
Query: 2214 PPGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPP 2272
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 774 AAASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PP 830
Query: 2273 FNYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 831 VRNPQNSTVLARGPASVPSVGKAVATA 857
Score = 87.0 bits (214), Expect = 2e-16
Identities = 270/1249 (21%), Positives = 423/1249 (33%), Gaps = 228/1249 (18%)
Query: 1106 SEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSV 1165
SE E + + A GA + P + A G+ + T SSS E V+ P V
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSA-----GQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
Query: 1166 SSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPE 1225
SS+ + ESP+ ++ P G+ G ++ P G +PP++ A P+ E
Sbjct: 226 SSVSTKESPARKAA----PAPGK-VGDVT----PQVKGGALPPAKR-----AKKPEEESE 271
Query: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
+++ + SE +A + + K E + SA A
Sbjct: 272 SSEEGSE---------------------SEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
A P G AG + E+ + + S +++E +
Sbjct: 311 PG----------KGATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKA 358
Query: 1346 CLGAAVPARLRKVASALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNF 1400
L A + +V +A P + A P P PA A AQ DS
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS-------- 410
Query: 1401 SSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GR 1450
S++ SD + P + +P G A + R P G K G A G+
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 1451 SAEQSRGAGKN-----------RAGLELPLGRPPSA-PADKDGSKPGRTRGDGALQSLCL 1498
E SR + + A PLG+ P PA G P +G G + +
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP-LGKGAGPVPPGKV 529
Query: 1499 TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAA 1558
T A + DS+ ++ + +A+ A +E+ G P+ ++PA
Sbjct: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA--QEKSLGNILQAKPT-SSPAK 586
Query: 1559 PPPARTQPSL--IADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGR 1616
PP + P + E P S SS SS S P A+ +PA+ K P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL-KIPQTKACP 645
Query: 1617 DSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSD 1676
+ + +A+ R + + PR+ + P +RPAE S EE+ +
Sbjct: 646 KKTNTTASAKVAPVR-VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEE 703
Query: 1677 RASDLDSVEWRAIQEG-ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKH 1735
+ L A+ G A S+ L AA+ S + G G T+ K
Sbjct: 704 EKTGL------AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG-KTGPTVTQVKA 756
Query: 1736 RKGRQAEGEMGSARRPEKRGA-----ASVKTSGSPRSPAGPEKP--RGT-----QKTTPG 1783
K +E + E + SVK + + +PA P +GT + T
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRS 1840
A R + + P P+ GP + P + VA AQ P +
Sbjct: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ-------TGPEEDSG 869
Query: 1841 RSLHRPAKTSELATLSQ-PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA 1899
S E TL+Q P T R A P+ S + A P P K P AG
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGK 928
Query: 1900 LPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGT 1959
G+S + S P A+ PPL P P G A T
Sbjct: 929 QDDSGSS--------------SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 1960 EA-GPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAA 2018
A A R ++A SS SES D +PG+R + +A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL---TPGIRTNVVTMPTAHP-- 1029
Query: 2019 SAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPG---ERPARR 2075
R AP+ A A ++R S G E PA +
Sbjct: 1030 ----------------------------RIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Query: 2076 TTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRP 2135
+ ++P+ LP+ A + K + P ++ +P V +A + A S
Sbjct: 1062 VSKKNPASLPLTQAALKVLAQKASEAQPPVA-RTQPSSGVDSAVGTLPATSPQSTS---- 1116
Query: 2136 LPRVAAPGTTWRRIRDEDVPHILRSTL-------------PATALPLRGSTPEDAPA--- 2179
V A GT ++R +P + ++T ++ G P+ A +
Sbjct: 1117 ---VQAKGT--NKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1171
Query: 2180 -GPPPRKTSDAVVQT------EEVAAPK------------TNSSTSPSLETREPPGAPAG 2220
GP P +T V +T ++V AP T +++ S T + +P+
Sbjct: 1172 LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1231
Query: 2221 GQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSAR 2269
D DG AK +A L GG A+ +P +S +
Sbjct: 1232 SSTLAAKDDPDGKQEAKPQQAAGM----LSPKTGGKEAASGTTPQKSRK 1276
Score = 74.7 bits (182), Expect = 1e-12
Identities = 236/1138 (20%), Positives = 392/1138 (34%), Gaps = 221/1138 (19%)
Query: 758 LPPLRHLDGLAQDY-ASDSGCFDDDDAPSSL---------------AAAAATGEPASPAA 801
LPP + ++ +S+ G +++AP+ A+A A G P A
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA- 315
Query: 802 LSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDI 861
+P G+A A T+ G E + ++S E + ++ + A A+ +
Sbjct: 316 ------TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK------ 363
Query: 862 SALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHAS 921
S S ++ P +E+PR+G A + GP + +AG R ++ S
Sbjct: 364 ----ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEES 417
Query: 922 LSNDSLNSGSASDGYCPREHMLPCP--------LAALASRREDPRCGQPRPSRLDLDLPG 973
S + + + G P+ P A R+ P Q + + + D
Sbjct: 418 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 974 CQAEPPA-REATSA--DARVRTIKLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQA 1029
E + REA +A A+V+ + SP ++ AS G PL G G P +
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 1030 WLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSE 1086
P+ + K E ++ + + ++ P SL SS + P +
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 1087 GG----------DLDDSDSSLEGLEEAGPSEA-------------ELDSTWRAPGATS-- 1121
G +D+S+SS E + A EA ++ T P T+
Sbjct: 592 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
Query: 1122 -------LPVAIPAPRR--------------NRGRGLGVEDATPSSSSENYVQETPLVLS 1160
+ V APR+ G ED++ S S++ ++T L ++
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
Query: 1161 RCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAP 1220
S+G A+S+P + GQG+ + P + + Q + + + +
Sbjct: 712 -VGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEE 768
Query: 1221 QGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCAS---- 1276
EA Q ++ VK+ A+ P+ A S + T+ P + + A+
Sbjct: 769 SDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 1277 -SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGA 1335
S S + Q L P++ P G A + + GP
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA-------QAQTGPEEDSGSSEEE 874
Query: 1336 ADQELELLRECLGAAVPA-RLRKVASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDS 1388
+D E E E L P+ + ++ +AL P + A P P P+ A A ++DDS
Sbjct: 875 SDSEEE--AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 1389 CTDSAEGTPVNFSSAASLSDETLQGP-----PRDQPGGPAGRQRPTGRPTSARQAMGHRH 1443
+ S E + AA S + ++ P P P GPA ++ R+A
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1444 KAGGAGRSAE--------QSRGAGKNRAGLELPLGRPPSAP----ADKDGSKPGRTRGDG 1491
A + +E Q G + +P P AP A SK DG
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 1492 ALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAP 1551
Q E PA + + + + +A + Q
Sbjct: 1053 KKQ----------------------EGPATQVSKKNPASLPLTQAALKVLAQ-------- 1082
Query: 1552 SKAAPAAPPPARTQPSLIADE-------TPPCYSLSSSASSLSEPEPSEPPAVHPRGREP 1604
KA+ A PP ARTQPS D T P S S A ++ + P V + P
Sbjct: 1083 -KASEAQPPVARTQPSSGVDSAVGTLPATSP-QSTSVQAKGTNKLRKPKLPEVQQATKAP 1140
Query: 1605 AVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEG 1664
+ D DSS S +EE P+ L P +R + E
Sbjct: 1141 ESSDD-----SEDSSDSSSGSEE------DGEGPQGAKSAHTL---GPTPSRTETLVEET 1186
Query: 1665 SRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGL 1724
+ E E+ + S L + ANS QA+ AT + S
Sbjct: 1187 AAESSEDDVVAPSQSLLSGYMTPGLTP-ANS------QASKATPKLDSSP---------- 1229
Query: 1725 SVGSTLQPPKHRKGRQ-AEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTT 1781
SV STL G+Q A+ + + K G + +P+ P+K G + +
Sbjct: 1230 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1287
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 87.0 bits (214), Expect = 2e-16
Identities = 195/867 (22%), Positives = 313/867 (36%), Gaps = 115/867 (13%)
Query: 1482 SKPGRTRG---DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
S+ GR R D ALQ+ T + + ++ +EE A T R S
Sbjct: 57 SELGRKRKAEEDAALQAK--KTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 1539 RERPQGRKE-----APAPSKAAPAAPPPA--RTQPSLIADETPPCYSLSSSASSL---SE 1588
+ P KE K + P PA +T +L++ ++P + S+ ++L +E
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 1589 PEPSEP-------PAVHPRGREPAVTKDPGPGGGR---DSSPSPRAAEELLQRCISSALP 1638
E S P P + G+ + ++D + PS + A+ + P
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 1639 RRR--PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI 1696
R+ P + P+ PA+ +++ EE+ S+ S+ +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE------------- 281
Query: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA 1756
+A A TR S+ IL V + P K G+ A + P K GA
Sbjct: 282 -----EAPAGTRSQVKASEKILQ------VRAASAPAKGTPGKGA-----TPAPPGKAGA 325
Query: 1757 ASVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPR 1812
+ +T +G P S + E+ +++ TP A+L+ + + P K +P
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
A P APP PA ++ S+S + + E A P P R A P
Sbjct: 386 AAP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 1873 SSSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV- 1928
+ S + A P PRK P Q +S R LA + Q P+
Sbjct: 443 AKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
+ P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD
Sbjct: 502 KSPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDS 555
Query: 1989 SGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSR 2042
S +P + + A+ +S +G + G A+ P SS
Sbjct: 556 SDGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 2043 CEELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
A + PA A+ +P P P + T+ S PVR P
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA--- 669
Query: 2100 ASLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDED 2153
A P G+ PA PA ++ SD E G + +
Sbjct: 670 ------GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKS 717
Query: 2154 VPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETRE 2213
V L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 718 VGKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEE 773
Query: 2214 PPGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPP 2272
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 774 AAASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PP 830
Query: 2273 FNYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 831 VRNPQNSTVLARGPASVPSVGKAVATA 857
Score = 77.8 bits (190), Expect = 1e-13
Identities = 271/1241 (21%), Positives = 415/1241 (33%), Gaps = 250/1241 (20%)
Query: 1106 SEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSV 1165
SE E + + A GA + P + A G+ + T SSS E V+ P V
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSA-----GQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
Query: 1166 SSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPE 1225
SS+ + ESP+ ++ P G+ G ++ P G +PP++ A P+ E
Sbjct: 226 SSVSTKESPARKAA----PAPGK-VGDVT----PQVKGGALPPAKR-----AKKPEEESE 271
Query: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
+++ + SE +A + + K E + SA A
Sbjct: 272 SSEEGSE---------------------SEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
A P G AG + E+ + + S +++E +
Sbjct: 311 PG----------KGATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKA 358
Query: 1346 CLGAAVPARLRKVASALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNF 1400
L A + +V +A P + A P P PA A AQ DS
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS-------- 410
Query: 1401 SSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GR 1450
S++ SD + P + +P G A + R P G K G A G+
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 1451 SAEQSRGAGKN-----------RAGLELPLGRPPSA-PADKDGSKPGRTRGDGALQSLCL 1498
E SR + + A PLG+ P PA G P +G G + +
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP-LGKGAGPVPPGKV 529
Query: 1499 TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAA 1558
T A + DS+ ++ + +A+ A +E+ G P+ ++PA
Sbjct: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA--QEKSLGNILQAKPT-SSPAK 586
Query: 1559 PPPARTQPSL--IADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGR 1616
PP + P + E P S SS SS S P A+ +PA+ K P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL-KIPQTKACP 645
Query: 1617 DSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSD 1676
+ + +A+ R + + PR+ + P +RPAE S EE+ +
Sbjct: 646 KKTNTTASAKVAPVR-VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEE 703
Query: 1677 RASDLDSVEWRAIQEG-ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKH 1735
+ L A+ G A S+ L AA+ S + G G T+ K
Sbjct: 704 EKTGL------AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG-KTGPTVTQVKA 756
Query: 1736 RKGRQAEGEMGSARRPEKRGA-----ASVKTSGSPRSPAGPEKP--RGT-----QKTTPG 1783
K +E + E + SVK + + +PA P +GT + T
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRS 1840
A R + + P P+ GP + P + VA AQ P +
Sbjct: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ-------TGPEEDSG 869
Query: 1841 RSLHRPAKTSELATLSQ-PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA 1899
S E TL+Q P T R A P+ S + A P P K P AG
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGK 928
Query: 1900 LPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGT 1959
G+S + S P A+ PPL P P G A T
Sbjct: 929 QDDSGSS--------------SEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAAT 974
Query: 1960 EA-GPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAA 2018
A A R ++A SS SES D +PG+R + +A
Sbjct: 975 PAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL---TPGIRTNVVTMPTAHP-- 1029
Query: 2019 SAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPG---ERPARR 2075
R AP+ A A ++R S G E PA +
Sbjct: 1030 ----------------------------RIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Query: 2076 TTSESPSRLPVRAPAARPETVK-----RYASLPHISVARRPDGAVPAAPASADAARRSSD 2130
S + LP +P + K R LP + A + AP S+D + SSD
Sbjct: 1062 VDS-AVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATK-------APESSDDSEDSSD 1113
Query: 2131 GEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPA----GPPPRKT 2186
++ G+ +ED G P+ A + GP P +T
Sbjct: 1114 ---------SSSGS------EED-----------------GEGPQGAKSAHTLGPTPSRT 1141
Query: 2187 SDAVVQT------EEVAAPK------------TNSSTSPSLETREPPGAPAGGQLSLLGS 2228
V +T ++V AP T +++ S T + +P+
Sbjct: 1142 ETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKD 1201
Query: 2229 DVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSAR 2269
D DG AK +A L GG A+ +P +S +
Sbjct: 1202 DPDGKQEAKPQQAAGM----LSPKTGGKEAASGTTPQKSRK 1238
Score = 75.9 bits (185), Expect = 4e-13
Identities = 238/1163 (20%), Positives = 403/1163 (34%), Gaps = 211/1163 (18%)
Query: 758 LPPLRHLDGLAQDY-ASDSGCFDDDDAPSSL---------------AAAAATGEPASPAA 801
LPP + ++ +S+ G +++AP+ A+A A G P A
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA- 315
Query: 802 LSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDI 861
+P G+A A T+ G E + ++S E + ++ + A A+ +
Sbjct: 316 ------TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK------ 363
Query: 862 SALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHAS 921
S S ++ P +E+PR+G A + GP + +AG R ++ S
Sbjct: 364 ----ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEES 417
Query: 922 LSNDSLNSGSASDGYCPREHMLPCP--------LAALASRREDPRCGQPRPSRLDLDLPG 973
S + + + G P+ P A R+ P Q + + + D
Sbjct: 418 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 974 CQAEPPA-REATSA--DARVRTIKLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQA 1029
E + REA +A A+V+ + SP ++ AS G PL G G P +
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 1030 WLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSE 1086
P+ + K E ++ + + ++ P SL SS + P +
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 1087 GG----------DLDDSDSSLEGLEEAGPSEA-------------ELDSTWRAPGATS-- 1121
G +D+S+SS E + A EA ++ T P T+
Sbjct: 592 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
Query: 1122 -------LPVAIPAPRR--------------NRGRGLGVEDATPSSSSENYVQETPLVLS 1160
+ V APR+ G ED++ S S++ ++T L ++
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
Query: 1161 RCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAP 1220
S+G A+S+P + GQG+ + P + + Q + + + +
Sbjct: 712 -VGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEE 768
Query: 1221 QGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCAS---- 1276
EA Q ++ VK+ A+ P+ A S + T+ P + + A+
Sbjct: 769 SDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 1277 -SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGA 1335
S S + Q L P++ P G A + + GP
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA-------QAQTGPEEDSGSSEEE 874
Query: 1336 ADQELELLRECLGAAVPA-RLRKVASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDS 1388
+D E E E L P+ + ++ +AL P + A P P P+ A A ++DDS
Sbjct: 875 SDSEEE--AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 1389 CTDSAEGTPVNFSSAASLSDETLQGP-----PRDQPGGPAGRQRPTGRPTSARQAMGHRH 1443
+ S E + AA S + ++ P P P GPA ++ R+A
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 992
Query: 1444 KAGGAGRSAE--------QSRGAGKNRAGLELPLGRPPSAPAD--------------KDG 1481
A + +E Q G + +P P AP DG
Sbjct: 993 TARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDG 1052
Query: 1482 SKP--GRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTR 1539
K T+ D A+ +L T+P +V N + T S+ +
Sbjct: 1053 KKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSS 1112
Query: 1540 ERPQGRK---EAPAPSKAA-PAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPP 1595
+ G + E P +K+A P P+RT+ + +ET + SS + P S
Sbjct: 1113 DSSSGSEEDGEGPQGAKSAHTLGPTPSRTE--TLVEET----AAESSEDDVVAPSQSLLS 1166
Query: 1596 AVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRAT 1655
G PA ++ DSSPS +SS L + P G + KP+
Sbjct: 1167 GYMTPGLTPANSQASKATPKLDSSPS-----------VSSTLAAKDDP-DGKQEAKPQQA 1214
Query: 1656 RLDERPAEGSRE-----------RGEEAAGSDRASDLDSVEWRAIQEGANSIV---TWLH 1701
P G +E + ++ AG+ +AS L A+Q + W
Sbjct: 1215 AGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTL------ALQSNITQCLLGQPWPL 1268
Query: 1702 QAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKG-----RQAEGEMGSARRPEKRGA 1756
A +L V +T + RKG R+ G+ +AR P +
Sbjct: 1269 NEAQVQASVVKVLTELLEQERKKVVDTTKE--SSRKGWESRKRKLSGDQPAARTPRSKKK 1326
Query: 1757 ASVKTSGSPRSPAGPEKPRGTQK 1779
+ + PEK T K
Sbjct: 1327 KKLGAGEGGEASVSPEKTSTTSK 1349
Score = 68.2 bits (165), Expect = 9e-11
Identities = 193/958 (20%), Positives = 332/958 (34%), Gaps = 119/958 (12%)
Query: 1379 APAPAQEDDSCTDSA--EGTP------VNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG 1430
A + +++ S +D EG P V SS ++ + P G Q G
Sbjct: 196 ADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG 255
Query: 1431 RPTSARQAMGHRHKAGGA--GRSAEQSRGAGKN---RAGLELPLGRPPSAPADKD---GS 1482
A++A ++ + G +E+ AG +A ++ R SAPA G+
Sbjct: 256 ALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA 315
Query: 1483 KPGRTRGDGALQSLCLTTPTEEAVYCFY--GNDSDEEPPAAAPTPTHRRTSAIPRAFTRE 1540
P GA+ S EE +DS+EE PAA A+ +A
Sbjct: 316 TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAA---------KALLQAKASG 366
Query: 1541 RPQGRKEAPAPSKAAP---AAP-PPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPA 1596
+ A AP+K +P AAP PP +T P++ + S S+S S+ E P
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
P G+ P V RAA + P + P G PR T
Sbjct: 427 AKPSGKAPQV----------------RAA----------SAPAKESPRKGAAPAPPRKTG 460
Query: 1657 LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDS 1716
PA + G++ S R+S +S R N+ + + AS+
Sbjct: 461 ----PAAAQVQVGKQEEDS-RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMG 515
Query: 1717 ILSFVSGLSVGSTLQP--PKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
L +G + P P + G+ E S+ V T+ +P EK
Sbjct: 516 PLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ----EKS 571
Query: 1775 RGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS 1834
G +L+ + P+ +P P GP A K P ++ S
Sbjct: 572 LGN---------ILQAK-----PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 1835 PGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPA--SQPLPRKRPP 1892
+ + + A+ L P A P KT +++S++ +P PRK
Sbjct: 618 ADSEEAPAAMTAAQAKP--ALKIPQTKACPK----KTNTTASAKVAPVRVGTQAPRKAGT 671
Query: 1893 VTQAAGALPG-PGASPVPKTPARTLLAKQHKTQRSPVRIPFMQ-RPARRGPPPLARAVPE 1950
T AG+ P G + P + + + +++ + + Q + +G A +VP
Sbjct: 672 ATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPV 731
Query: 1951 PGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSE 2010
G G+ PG G + V+ S S + + + +++ +++
Sbjct: 732 KGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 791
Query: 2011 LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP--APARQRPPAARPSP 2068
+ A + A + +G G+ + A R P + P + R PA+ PS
Sbjct: 792 ANPAAARAPSAKGTISAPGK-VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSV 850
Query: 2069 GERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRS 2128
G+ A +++ + ++ + +L + + + A + ++ R+
Sbjct: 851 GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKG 910
Query: 2129 SDGEP--RPLPRVAAPG-------TTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPA 2179
+ P + P A G ++ D + P + S PL P +PA
Sbjct: 911 AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA-QVIKPPLIFVDPNRSPA 969
Query: 2180 GPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAP 2239
GP T A +++ S S E+ + PA L+ P +
Sbjct: 970 GPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLT--------PGIRTNV 1021
Query: 2240 ISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATA 2297
++ P H + AS S S+R+ P A DSA PAT+
Sbjct: 1022 VTMPTAHPRIAPKASMAGAS---SSKESSRISDGKKQEGP---ATQVDSAVGTLPATS 1073
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
sapiens]
Length = 958
Score = 87.0 bits (214), Expect = 2e-16
Identities = 195/867 (22%), Positives = 313/867 (36%), Gaps = 115/867 (13%)
Query: 1482 SKPGRTRG---DGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
S+ GR R D ALQ+ T + + ++ +EE A T R S
Sbjct: 57 SELGRKRKAEEDAALQAK--KTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLG 114
Query: 1539 RERPQGRKE-----APAPSKAAPAAPPPA--RTQPSLIADETPPCYSLSSSASSL---SE 1588
+ P KE K + P PA +T +L++ ++P + S+ ++L +E
Sbjct: 115 ADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETE 174
Query: 1589 PEPSEP-------PAVHPRGREPAVTKDPGPGGGR---DSSPSPRAAEELLQRCISSALP 1638
E S P P + G+ + ++D + PS + A+ + P
Sbjct: 175 EEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESP 234
Query: 1639 RRR--PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSI 1696
R+ P + P+ PA+ +++ EE+ S+ S+ +
Sbjct: 235 ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEE------------- 281
Query: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA 1756
+A A TR S+ IL V + P K G+ A + P K GA
Sbjct: 282 -----EAPAGTRSQVKASEKILQ------VRAASAPAKGTPGKGA-----TPAPPGKAGA 325
Query: 1757 ASVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPR 1812
+ +T +G P S + E+ +++ TP A+L+ + + P K +P
Sbjct: 326 VASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1813 ATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTP 1872
A P APP PA ++ S+S + + E A P P R A P
Sbjct: 386 AAP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 1873 SSSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV- 1928
+ S + A P PRK P Q +S R LA + Q P+
Sbjct: 443 AKESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG 501
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
+ P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD
Sbjct: 502 KSPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDS 555
Query: 1989 SGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSR 2042
S +P + + A+ +S +G + G A+ P SS
Sbjct: 556 SDGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE 612
Query: 2043 CEELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
A + PA A+ +P P P + T+ S PVR P
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA--- 669
Query: 2100 ASLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDED 2153
A P G+ PA PA ++ SD E G + +
Sbjct: 670 ------GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKS 717
Query: 2154 VPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETRE 2213
V L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 718 VGKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEE 773
Query: 2214 PPGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPP 2272
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 774 AAASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PP 830
Query: 2273 FNYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 831 VRNPQNSTVLARGPASVPSVGKAVATA 857
Score = 66.6 bits (161), Expect = 3e-10
Identities = 188/847 (22%), Positives = 292/847 (34%), Gaps = 128/847 (15%)
Query: 1106 SEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSV 1165
SE E + + A GA + P + A G+ + T SSS E V+ P V
Sbjct: 171 SETEEEGSVPAFGAAAKPGMVSA-----GQADSSSEDTSSSSDETDVEGKPSVKPAQVKA 225
Query: 1166 SSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPE 1225
SS+ + ESP+ ++ P G+ G ++ P G +PP++ A P+ E
Sbjct: 226 SSVSTKESPARKAA----PAPGK-VGDVT----PQVKGGALPPAKR-----AKKPEEESE 271
Query: 1226 ATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHE 1285
+++ + SE +A + + K E + SA A
Sbjct: 272 SSEEGSE---------------------SEEEAPAGTRSQVKASEKILQVRAASAPAKGT 310
Query: 1286 HYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRE 1345
A P G AG + E+ + + S +++E +
Sbjct: 311 PG----------KGATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKA 358
Query: 1346 CLGAAVPARLRKVASALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNF 1400
L A + +V +A P + A P P PA A AQ DS
Sbjct: 359 LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS-------- 410
Query: 1401 SSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GR 1450
S++ SD + P + +P G A + R P G K G A G+
Sbjct: 411 QSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGK 470
Query: 1451 SAEQSRGAGKN-----------RAGLELPLGRPPSA-PADKDGSKPGRTRGDGALQSLCL 1498
E SR + + A PLG+ P PA G P +G G + +
Sbjct: 471 QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP-LGKGAGPVPPGKV 529
Query: 1499 TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAA 1558
T A + DS+ ++ + +A+ A +E+ G P+ ++PA
Sbjct: 530 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA--QEKSLGNILQAKPT-SSPAK 586
Query: 1559 PPPARTQPSL--IADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGR 1616
PP + P + E P S SS SS S P A+ +PA+ K P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPAL-KIPQTKACP 645
Query: 1617 DSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSD 1676
+ + +A+ R + + PR+ + P +RPAE S EE+ +
Sbjct: 646 KKTNTTASAKVAPVR-VGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDS-SSSEESDSEE 703
Query: 1677 RASDLDSVEWRAIQEG-ANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKH 1735
+ L A+ G A S+ L AA+ S + G G T+ K
Sbjct: 704 EKTGL------AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG-KTGPTVTQVKA 756
Query: 1736 RKGRQAEGEMGSARRPEKRGA-----ASVKTSGSPRSPAGPEKP--RGT-----QKTTPG 1783
K +E + E + SVK + + +PA P +GT + T
Sbjct: 757 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 816
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP---RKVAPPCLAQPAAPAKVPSPGQQRS 1840
A R + + P P+ GP + P + VA AQ P +
Sbjct: 817 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ-------TGPEEDSG 869
Query: 1841 RSLHRPAKTSELATLSQ-PPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA 1899
S E TL+Q P T R A P+ S + A P P K P AG
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP-PGKTGPSAAQAGK 928
Query: 1900 LPGPGAS 1906
G+S
Sbjct: 929 QDDSGSS 935
Score = 60.5 bits (145), Expect = 2e-08
Identities = 192/944 (20%), Positives = 312/944 (33%), Gaps = 176/944 (18%)
Query: 829 AEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGR 888
+E E A A AKA LA L D+ + + + +G G P
Sbjct: 85 SESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPAT 144
Query: 889 AQSCSPCRGPEGGRREAGSRAHPLL--------------------RLKAAHASLSNDSLN 928
++ + + R+ A A+ L + A A S++ +
Sbjct: 145 GKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTS 204
Query: 929 SGSASDGYCPREHMLPCPL-AALASRREDP-RCGQPRPSRLDLDL----------PGCQA 976
S S + + P + A+ S +E P R P P ++ D+ P +A
Sbjct: 205 SSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVG-DVTPQVKGGALPPAKRA 263
Query: 977 EPPAREATSADARVRTIKLSP--TYQHVPLLEG-----ASRAGAEPLAGPGISPGARKQA 1029
+ P E+ S++ + + +P T V E A+ A A+ G G +P +A
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 1030 WLPADHLSK-VPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSA--------- 1079
A PE+ + + +S + ++ A + L S + +A
Sbjct: 324 GAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383
Query: 1080 --------GRPGPS-----EGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPG--ATSLPV 1124
G+ GP+ G +DS SS E + + A+ + +AP A S P
Sbjct: 384 KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443
Query: 1125 -------AIPAPRRNRGRGLGV------EDATPSSSSENYVQETPLVLSRCSSVSSLGSF 1171
A PAP R G E+ + SSS E+ L + V LG
Sbjct: 444 KESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLG-- 501
Query: 1172 ESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSL 1231
+SP + +P S G G + P PG K P P+ Q
Sbjct: 502 KSPQV------KPASTMGMGPLGKGAGPVPPG--------KVGPATPSAQVG-------- 539
Query: 1232 QWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQD 1291
+WE D S+ G V V E SL +
Sbjct: 540 KWEE---------DSESSSEESSDSSDGEVPTAVAPAQEK-----SLGNI---------- 575
Query: 1292 VELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAV 1351
L+ P++ P +G + + + + +AD E
Sbjct: 576 --LQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE------------ 621
Query: 1352 PARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETL 1411
A A + +A P + +P + + T SA+ PV + A T
Sbjct: 622 ------EAPAAMTAAQAKPA---LKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
Query: 1412 QGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGR 1471
P P G QRP +S+ ++ K G A + Q++ GK GL++
Sbjct: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLA-VTVGQAKSVGK---GLQVKAAS 728
Query: 1472 PPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH-RRT 1530
P + G+ P G + E++ +DS+E + A T ++T
Sbjct: 729 VPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKT 788
Query: 1531 SAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPE 1590
A P + AP K AA + PS + PP + + S++
Sbjct: 789 QAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKV---KPPVRNPQN--STVLARG 843
Query: 1591 PSEPPAVHPRGREPAVTKDPGP----GGGRDSSPSPRAAEELLQ-------RCISSAL-P 1638
P+ P+V + A GP G + S S AE L Q I +AL P
Sbjct: 844 PASVPSV-GKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAP 902
Query: 1639 RRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLD 1682
+ P G P T P+ + +++ S SD D
Sbjct: 903 AKESPRKGAAPTPPGKT----GPSAAQAGKQDDSGSSSEESDSD 942
Score = 53.1 bits (126), Expect = 3e-06
Identities = 151/739 (20%), Positives = 265/739 (35%), Gaps = 133/739 (17%)
Query: 758 LPPLRHLDGLAQDY-ASDSGCFDDDDAPSSL---------------AAAAATGEPASPAA 801
LPP + ++ +S+ G +++AP+ A+A A G P A
Sbjct: 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGA- 315
Query: 802 LSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDI 861
+P G+A A T+ G E + ++S E + ++ + A A+ +
Sbjct: 316 ------TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAK------ 363
Query: 862 SALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHAS 921
S S ++ P +E+PR+G A + GP + +AG R ++ S
Sbjct: 364 ----ASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEES 417
Query: 922 LSNDSLNSGSASDGYCPREHMLPCP--------LAALASRREDPRCGQPRPSRLDLDLPG 973
S + + + G P+ P A R+ P Q + + + D
Sbjct: 418 DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRS 477
Query: 974 CQAEPPA-REATSA--DARVRTIKLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQA 1029
E + REA +A A+V+ + SP ++ AS G PL G G P +
Sbjct: 478 SSEESDSDREALAAMNAAQVKPLGKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGP 531
Query: 1030 WLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSE 1086
P+ + K E ++ + + ++ P SL SS + P +
Sbjct: 532 ATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQK 591
Query: 1087 GG----------DLDDSDSSLEGLEEAGPSEA-------------ELDSTWRAPGATS-- 1121
G +D+S+SS E + A EA ++ T P T+
Sbjct: 592 AGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
Query: 1122 -------LPVAIPAPRR--------------NRGRGLGVEDATPSSSSENYVQETPLVLS 1160
+ V APR+ G ED++ S S++ ++T L ++
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
Query: 1161 RCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAP 1220
S+G A+S+P + GQG+ + P + + Q + + + +
Sbjct: 712 -VGQAKSVGKGLQVK-AASVPVKGSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEE 768
Query: 1221 QGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCAS---- 1276
EA Q ++ VK+ A+ P+ A S + T+ P + + A+
Sbjct: 769 SDSEEAAASPAQVKTSVKKTQAKAN-------PAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 1277 -SLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGA 1335
S S + Q L P++ P G A + + GP
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA-------QAQTGPEEDSGSSEEE 874
Query: 1336 ADQELELLRECLGAAVPA-RLRKVASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDS 1388
+D E E E L P+ + ++ +AL P + A P P P+ A A ++DDS
Sbjct: 875 SDSEEE--AETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS 932
Query: 1389 CTDSAEGTPVNFSSAASLS 1407
+ S E + AA S
Sbjct: 933 GSSSEESDSDGEAPAAVTS 951
>gi|239752594 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 673
Score = 85.5 bits (210), Expect = 6e-16
Identities = 167/715 (23%), Positives = 240/715 (33%), Gaps = 85/715 (11%)
Query: 1414 PPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPP 1473
PP P R PT P++A G +A G + S +RA L G PP
Sbjct: 3 PPTRTPS----RASPTRTPSTA-SLTGTPSRASLTGTPSTASLMGTPSRASLT---GTPP 54
Query: 1474 SAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPT----PTHRR 1529
A +G ++ SL + +P+ ++ + P+ A P R
Sbjct: 55 RASL----------KGTTSMASL-MVSPSRASLTRMQSSSLLTRTPSMASLKRMPPRASR 103
Query: 1530 TSAIPRAFTRERPQGRKEAPAPSKAAPAAPPP------------ARTQPSLIA-DETPPC 1576
T +PRA RP +PS+A+ P A T PS + TPP
Sbjct: 104 TRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTPPR 163
Query: 1577 YSLSS--SASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCIS 1634
SL+ S +SL+ P P P P DS+ S + R +S
Sbjct: 164 ASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTKMDSTAS-------ITRTLS 216
Query: 1635 SALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAA---GSDRASDLDSVEWRAIQE 1691
A P PP + PRA+ L P+ R A G + L ++ A
Sbjct: 217 RASPTGTPPRASPTGSPPRAS-LSMMPSTALLIRTPPRASPTGMLSRTSLTKMDSTASIT 275
Query: 1692 GANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRP 1751
S + +R + S + S S + L S + + +R P
Sbjct: 276 RTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTP 335
Query: 1752 EKRGAASVKTSGSPRSPAGPEKPRGT--QKTTPGVPAVLRGRTVIYVPSPA---PRAQPK 1806
+ + SP P GT + + G P+ + SP PRA P
Sbjct: 336 PRASITRTPSRASPTGKPSTASPTGTPSRASPTGSPSTASLTGLSSTASPTGTPPRASPT 395
Query: 1807 GTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPA 1866
GTP + RK P A P S + S + P +T A+ + P A+P
Sbjct: 396 GTPSTASLTRK---PPRASPTGMLSRTSITKMDSTA--SPTRTPPRASPTGTPPRASPTG 450
Query: 1867 RLAK-TPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKT-- 1923
++ +P+ + S SP P A P + + +TP+R L K T
Sbjct: 451 TPSRASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTAS 510
Query: 1924 -QRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSG 1982
R+P R P+ P G RA P R L R S S
Sbjct: 511 ITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAALTRTP----SRASLTRTPSRASLT 566
Query: 1983 SESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSR 2042
+ S R LT + L R + + S P SP G P+ + S
Sbjct: 567 TPS------RASLTRTPSTVLLTR----MPPSASPTGMPSRTSP-TGMPSSALLTKMDST 615
Query: 2043 CEELRAAPRQGPAPARQRPPAARPS---PGERPARRTTSESPSRLPVRA-PAARP 2093
R PR P + PP A P+ P P SP+ P RA P P
Sbjct: 616 ASITRTPPRASPT---ETPPRASPTGTPPRASPTGTPPRASPTGTPPRASPTGTP 667
Score = 79.0 bits (193), Expect = 5e-14
Identities = 164/723 (22%), Positives = 240/723 (33%), Gaps = 109/723 (15%)
Query: 1550 APSKAAPAAPPPARTQPSLIADETPPCYSLS---SSASSLSEPEPSEPPAVHPRGREPAV 1606
AP P+ P RT + TP SL+ S+AS + P + PR A
Sbjct: 2 APPTRTPSRASPTRTPSTASLTGTPSRASLTGTPSTASLMGTPSRASLTGTPPR----AS 57
Query: 1607 TKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSR 1666
K SPS RA+ L R SS+L R P ++ L+R PRA+R P S
Sbjct: 58 LKGTTSMASLMVSPS-RAS---LTRMQSSSLLTRTPSMASLKRMPPRASRTRTLP-RASL 112
Query: 1667 ERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSV 1726
R A R+ S+ +R + S + S + ++ S
Sbjct: 113 MRRPSTASLTRSPSRASL------------------TTTPSRASLSMTPSTAAALTMPSR 154
Query: 1727 GSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQK--TTPGV 1784
S + P R P + AS S SP G K +T +
Sbjct: 155 ASLTRTPPRASLTMTPSTASLTRTPPR---ASPTGMPSRTSPTGMPSTASLTKMDSTASI 211
Query: 1785 PAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLH 1844
L + P PRA P G+P PRA+ + L P P+ G SL
Sbjct: 212 TRTLSRASPTGTP---PRASPTGSP-PRASLSMMPSTALLIRTPPRASPT-GMLSRTSLT 266
Query: 1845 RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPG 1904
+ T+ + P +A+P TPS +S +P++ L R P
Sbjct: 267 KMDSTASITRTPSRPSTASPTG----TPSRASLSMTPSTASLMRMLPR------------ 310
Query: 1905 ASPVPKTPARTLLAKQHKT---QRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEA 1961
ASP +RT L K T R+P R + P+R P G RA
Sbjct: 311 ASPTGML-SRTSLTKMDSTASISRTPPRASITRTPSRASPTGKPSTASPTGTPSRASPTG 369
Query: 1962 GPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE----SPGLRRRRSELSSAESA 2017
P GL AS + +S +G + ++ SP R+ ++ +S
Sbjct: 370 SPST-ASLTGLSSTASPTGTPPRASP-TGTPSTASLTRKPPRASPTGMLSRTSITKMDST 427
Query: 2018 AS--------APQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPG 2069
AS +P G PR P+ S + A+P P+ A + SP
Sbjct: 428 ASPTRTPPRASPTGTPPRASPTGTPS--RASPTGTQSTASPTGSPSTASPTGSPSTASPT 485
Query: 2070 ERPARRTTSESPSRL--------------PVRA----------PAARPETVKRYASLPHI 2105
P+R + + +PSR P RA P P T S
Sbjct: 486 GSPSRASLTRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRA 545
Query: 2106 ---------SVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPH 2156
S+ R P A P+ A R S +P A+P R +P
Sbjct: 546 ALTRTPSRASLTRTPSRASLTTPSRASLTRTPSTVLLTRMPPSASPTGMPSRTSPTGMPS 605
Query: 2157 ILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPG 2216
T + + + P +P PPR + +S + + P G
Sbjct: 606 SALLTKMDSTASITRTPPRASPTETPPRASPTGTPPRASPTGTPPRASPTGTPPRASPTG 665
Query: 2217 APA 2219
P+
Sbjct: 666 TPS 668
Score = 77.8 bits (190), Expect = 1e-13
Identities = 149/604 (24%), Positives = 219/604 (36%), Gaps = 108/604 (17%)
Query: 1767 SPAGPEKPRGTQKTTPGVP--AVLRGR--TVIYVPSPAPRAQPKGTPGPRATPRKVAPPC 1822
S A P + T T G P A L G T + +P+ RA GTP PRA+ K
Sbjct: 9 SRASPTRTPSTASLT-GTPSRASLTGTPSTASLMGTPS-RASLTGTP-PRAS-LKGTTSM 64
Query: 1823 LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQ-PPRSAT----PPARLAKTPSSSSS 1877
+ +P++ Q S L R T +A+L + PPR++ P A L + PS++S
Sbjct: 65 ASLMVSPSRASLTRMQSSSLLTR---TPSMASLKRMPPRASRTRTLPRASLMRRPSTASL 121
Query: 1878 QTSPA-----SQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQ---RSPVR 1929
SP+ + P A AL P + + +TP R L T R+P R
Sbjct: 122 TRSPSRASLTTTPSRASLSMTPSTAAALTMPSRASLTRTPPRASLTMTPSTASLTRTPPR 181
Query: 1930 IPFMQRPARRGPP-------------------PLARAVPEPGPRGRAGTEAGPGARGGRL 1970
P+R P L+RA P P + T + P A L
Sbjct: 182 ASPTGMPSRTSPTGMPSTASLTKMDSTASITRTLSRASPTGTPPRASPTGSPPRAS---L 238
Query: 1971 GLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGR 2030
++ + L + +G + + K +S S P ASP G
Sbjct: 239 SMMPSTALLIRTPPRASPTGMLSRTSLTK--------MDSTASITRTPSRPSTASPT-GT 289
Query: 2031 PALPAVFLCSSRCEELRAAPRQGP---------------APARQRPPAA-------RPSP 2068
P+ ++ + S +R PR P A + PP A R SP
Sbjct: 290 PSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTKMDSTASISRTPPRASITRTPSRASP 349
Query: 2069 GERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRS 2128
+P+ + + +PSR +P P T ASL +S P G P A + + S
Sbjct: 350 TGKPSTASPTGTPSRA---SPTGSPST----ASLTGLSSTASPTGTPPRASPTGTPSTAS 402
Query: 2129 SDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLR----GSTPEDAPAGPPPR 2184
+P PR + G R + + ST T P R G+ P +P G P R
Sbjct: 403 LTRKP---PRASPTGMLSRTSITK-----MDSTASPTRTPPRASPTGTPPRASPTGTPSR 454
Query: 2185 KTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDV------DGPSLAKA 2238
+ T + +S + S T P G+P+ L+ S S+ +
Sbjct: 455 ASPTGTQSTASPTGSPSTASPTGSPSTASPTGSPSRASLTRTPSRASLTKMESTASITRT 514
Query: 2239 PISAPFVHEGLGVAVGGFP--ASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPAT 2296
P A + G P A GSPSR+A PS + T A+ P+
Sbjct: 515 PSRASPTWTPSTASPTGSPSTALAMGSPSRAA----LTRTPSRASLTRTPSRASLTTPSR 570
Query: 2297 ASAT 2300
AS T
Sbjct: 571 ASLT 574
Score = 62.0 bits (149), Expect = 7e-09
Identities = 139/617 (22%), Positives = 206/617 (33%), Gaps = 80/617 (12%)
Query: 1332 PRGAADQEL---ELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDS 1388
PR + + L L+R A++ + + P R +L + P+ A A S
Sbjct: 99 PRASRTRTLPRASLMRRPSTASLTRSPSRASLTTTPSRASLS-----MTPSTAAALTMPS 153
Query: 1389 CTDSAEGTPVNFSSAASLSDETL-QGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGG 1447
S TP S + S +L + PPR P G R PTG P++A
Sbjct: 154 RA-SLTRTPPRASLTMTPSTASLTRTPPRASPTGMPSRTSPTGMPSTASLTK----MDST 208
Query: 1448 AGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSK------PGRTRGDGALQSLCLTTP 1501
A + SR + P G PP A S P R G L LT
Sbjct: 209 ASITRTLSRASPTGTPPRASPTGSPPRASLSMMPSTALLIRTPPRASPTGMLSRTSLTKM 268
Query: 1502 TEEAVYCFYGNDSDEEPPAAAPTPTHRR--------TSAIPRAFTRERPQGRKEAPAPSK 1553
A + P A+PT T R T+++ R R P G + +K
Sbjct: 269 DSTASI----TRTPSRPSTASPTGTPSRASLSMTPSTASLMRMLPRASPTGMLSRTSLTK 324
Query: 1554 AAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPG 1613
A +RT P TP S AS +P + P P P +
Sbjct: 325 MDSTASI-SRTPPRASITRTP------SRASPTGKPSTASPTGT-PSRASPTGSPSTASL 376
Query: 1614 GGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA-----------TRLDERPA 1662
G S+ SP A P P + L R+ PRA T++D +
Sbjct: 377 TGLSSTASPTGTPP-------RASPTGTPSTASLTRKPPRASPTGMLSRTSITKMDSTAS 429
Query: 1663 EGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVS 1722
G+ + RA G S + + + + + S S S
Sbjct: 430 PTRTPPRASPTGTPPRASPTGTPSRASPTGTQSTAS---PTGSPSTASPTGSPSTASPTG 486
Query: 1723 GLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGA----ASVKTSGSPRSPAGPEKP-RGT 1777
S S + P + E R P + ++ +GSP + P R
Sbjct: 487 SPSRASLTRTPSRASLTKMESTASITRTPSRASPTWTPSTASPTGSPSTALAMGSPSRAA 546
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQ 1837
TP ++ R + + +P+ RA TP R PP + P++ G
Sbjct: 547 LTRTPSRASLTRTPSRASLTTPS-RASLTRTPSTVLLTRM--PPSASPTGMPSRTSPTGM 603
Query: 1838 QRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAA 1897
S L K A++++ P A+P +TP +S +P + P PP
Sbjct: 604 PSSALL---TKMDSTASITRTPPRASP----TETPPRASPTGTPP-RASPTGTPPRASPT 655
Query: 1898 GALPGPGASPVPKTPAR 1914
G P ASP TP+R
Sbjct: 656 GT--PPRASPT-GTPSR 669
>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
Length = 1270
Score = 82.4 bits (202), Expect = 5e-15
Identities = 128/577 (22%), Positives = 195/577 (33%), Gaps = 55/577 (9%)
Query: 1764 SPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCL 1823
+P+ P P P+ TTP P T+ P+ P T TP++ AP
Sbjct: 212 TPKEPT-PTTPKEPASTTPKEPTPT---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 267
Query: 1824 AQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPA 1882
+PA K P+P + + P T T + P TP TP + T
Sbjct: 268 KEPAPTTPKEPAPTTTKEPA---PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 324
Query: 1883 SQPLPRKRPPVT--QAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRG 1940
P K P T + A P A PK PA T + T + P+
Sbjct: 325 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 384
Query: 1941 P----PPLARAVP----EPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFR 1992
P P ++ P EP P T++ P A ++ E + + +
Sbjct: 385 PKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK 441
Query: 1993 RQLTFIKE-SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPR 2051
T KE +P + + ++ + A + P+ +P + P + + AP
Sbjct: 442 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 501
Query: 2052 QGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASL----PHISV 2107
PA P P+ E P TT E P+ P AA P T K A P +
Sbjct: 502 TPEKPAPTTPEELAPTTPEEPT-PTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEPAPTT 558
Query: 2108 ARRPDGAVP--AAPASADAARRSSDGEP------RPLPRVAAPGTTWRRIR---DEDVPH 2156
+ P P AP + ++ EP +P P+ AP TT D+ P
Sbjct: 559 PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPT 618
Query: 2157 ILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS---PSL 2209
+ T P T +TP++ P G P + T + APK + T+ P+
Sbjct: 619 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 678
Query: 2210 ETREPPGAPAGGQLSLLGSDVDGPSLAKAPISA------PFVHEGLGVAVGGFPASRHGS 2263
T + P + + P+ K P P E P + H S
Sbjct: 679 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 738
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P S P + P+P + + T +AT
Sbjct: 739 PDES--TPELSAEPTPKALENSPKEPGVPTTKTPAAT 773
Score = 80.1 bits (196), Expect = 2e-14
Identities = 164/772 (21%), Positives = 260/772 (33%), Gaps = 126/772 (16%)
Query: 1380 PAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG----RPTSA 1435
PAP + T E P A + + +P + PT PT+
Sbjct: 247 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 306
Query: 1436 RQAMGHRHKAGGAGRSAEQSRGAGKNRAGL-ELPLGRPPSAPADKDGSKPGRTRGDGALQ 1494
++ K E + K A + P P PA KP T
Sbjct: 307 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------- 359
Query: 1495 SLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR----AFTRERPQGRKE-AP 1549
TP E A P APT T + P+ T+ P KE AP
Sbjct: 360 -----TPKEPA---------PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 405
Query: 1550 APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKD 1609
+K+AP P + T P ++ + P EP P+ P TK
Sbjct: 406 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 465
Query: 1610 PGPGGGRDSSP-SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDE----RPAEG 1664
P P ++ +P +P+ + ++ P + P + KP T +E P E
Sbjct: 466 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT---PEKPAPTTPEELAPTTPEEP 522
Query: 1665 SRERGEE-AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
+ EE A + +A+ ++ + A T + A T + ++ + G
Sbjct: 523 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-----KG 577
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPG 1783
+ + +P + A E+ E TS + PA P P+GT TTP
Sbjct: 578 TAPTTLKEPAPTTPKKPAPKELAPTTTKE-------PTSTTCDKPA-PTTPKGTAPTTPK 629
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGT-------PGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
PA + PAP PKGT P P TP+K AP + AP P
Sbjct: 630 EPAPTTPK------EPAP-TTPKGTAPTTLKEPAP-TTPKKPAP----KELAPTTTKGP- 676
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRS---ATPPARLAKTPSSSSSQTSPASQPLPRKRPPV 1893
S + +PA T+ T P+ TP TP + TS S P K P
Sbjct: 677 --TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 734
Query: 1894 TQAA--GALPGPGASPVPKTPARTLLAKQHKTQRSPVRI-PFMQRPAR--------RGPP 1942
+ + P A P PK + T ++P P M A+ R P
Sbjct: 735 IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP 794
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE-- 2000
A P+ TE ++ + + + + + D + F+ +T +K
Sbjct: 795 ETTTAAPKMTKETATTTEKTTESK------ITATTTQVTSTTTQDTTPFK--ITTLKTTT 846
Query: 2001 -SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQ 2059
+P + + +++ E + A P+ RA + P Q
Sbjct: 847 LAPKVTTTKKTITTTEIMNKPEETAKPKD------------------RATNSKATTPKPQ 888
Query: 2060 RPPAARPSPGERPARRTTSESPSRLP-VRAPAARPETVKRYASLPHISVARR 2110
+P A P + T+++ P +P VR P P K +++P ++ R
Sbjct: 889 KPTKA-------PKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSR 933
Score = 78.6 bits (192), Expect = 7e-14
Identities = 153/779 (19%), Positives = 252/779 (32%), Gaps = 93/779 (11%)
Query: 1468 PLGRPPSAPADKDGSKPGR--TRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTP 1525
P+ PS P + D SK + +++ TT ++ D E+ +A T
Sbjct: 123 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQT-----STDGKEKTTSAKETQ 177
Query: 1526 THRRTSA-----IPRAFTRERPQGRKEAPAPSKAAPAAPPPART-QPSLIADETPPCYSL 1579
+ +TSA + + P+ P+ P P P +P+ + P ++
Sbjct: 178 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 237
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S+ ++ EP P+ + +EPA T P P+P +E SA
Sbjct: 238 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 297
Query: 1640 RRPPVSGLRRRKPRATRLDE----RPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695
+ P +KP T E P E + +E A + + + + A
Sbjct: 298 PKEPAP-TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKP 356
Query: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG 1755
T + A T + + + +T +P A SA K
Sbjct: 357 APTTPKEPAPTTPKEPAPT-------------TTKEPSPTTPKEPAPTTTKSAPTTTKEP 403
Query: 1756 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP 1815
A + T +P +P P P T++ P P PAP K P TP
Sbjct: 404 APTT-TKSAPTTPKEPS-PTTTKEPAPTTPK-----------EPAPTTPKKPAP---TTP 447
Query: 1816 RKVAPPCLAQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
++ AP +PA K P+P T + P TP TP
Sbjct: 448 KEPAPTTPKEPAPTTTKKPAP------------------TTPKEPAPTTPKETAPTTPKK 489
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPAR----TLLAKQHKTQRSPVRI 1930
+ T P ++P T P P P TP T A T + P
Sbjct: 490 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 549
Query: 1931 PFMQRPARRGPPPLARAVPE----PGPRGRAGTE-AGPGARGGRLGLVRVASALSSGSES 1985
+ PA P A P+ P+G A T P + + + ++ +
Sbjct: 550 T-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 608
Query: 1986 SDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEE 2045
S T +P + + + E A + P+G +P + P +E
Sbjct: 609 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT-PKKPAPKE 667
Query: 2046 LRAAPRQGPA------PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
L +GP PA P P+ + PA T + P P E
Sbjct: 668 LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 727
Query: 2100 ASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILR 2159
+ ++ + PD + P SA+ ++ + P+ PG + P +
Sbjct: 728 TTKEPTTIHKSPDESTP--ELSAEPTPKALENSPK------EPGVPTTKTPAATKPEMTT 779
Query: 2160 STLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
+ T +TPE A P+ T + TE+ K ++T+ T P
Sbjct: 780 TAKDKTTERDLRTTPETTTAA--PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 836
Score = 77.8 bits (190), Expect = 1e-13
Identities = 159/775 (20%), Positives = 249/775 (32%), Gaps = 100/775 (12%)
Query: 1468 PLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH 1527
P P PA +P T A TTP E A + ++P P
Sbjct: 270 PAPTTPKEPAPTTTKEPAPTTTKSAP-----TTPKEPAP------TTPKKPAPTTPKEPA 318
Query: 1528 RRTSAIPRAFTRERPQGRKEAPAPS---KAAPAAPP-PARTQPSLIADETPPCYSLSSSA 1583
T P T + P + PAP+ + AP AP PA T P A TP +
Sbjct: 319 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK----EPAP 374
Query: 1584 SSLSEPEPSEP--PAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRR 1641
++ EP P+ P PA P TK+P P + + +P+ + + P+
Sbjct: 375 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 434
Query: 1642 PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLH 1701
P + +KP T P E + +E A + + T
Sbjct: 435 APTTP---KKPAPTT----PKEPAPTTPKEPAPTTTKKPAPT--------------TPKE 473
Query: 1702 QAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKT 1761
A +E + + L+ + L P K E + PE+ T
Sbjct: 474 PAPTTPKETAPTTPKKLT----PTTPEKLAPTTPEKPAPTTPEELAPTTPEE------PT 523
Query: 1762 SGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPP 1821
+P PA P P+ TP PA T P+P +P T TP++ AP
Sbjct: 524 PTTPEEPA-PTTPKAAAPNTPKEPAP----TTPKEPAPTTPKEPAPT-----TPKETAPT 573
Query: 1822 CLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSP 1881
+ AP + P + +PA T ++ P S T TP ++ T
Sbjct: 574 T-PKGTAPTTLKEPAPTTPK---KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 629
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP 1941
P K P T G P P P TP + + T +PA P
Sbjct: 630 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTP 689
Query: 1942 PPLARAVP-EPGP----RGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLT 1996
A P EP P + T P + ++ +S D S
Sbjct: 690 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES------- 742
Query: 1997 FIKESPGLRRRRSE--LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP 2054
+P L + L ++ P +P +P + + +LR P
Sbjct: 743 ----TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 798
Query: 2055 APARQRPPAARPSPG--ERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPD 2112
A + A + E TT++ S + T+K P ++ ++
Sbjct: 799 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTI 858
Query: 2113 GAV-----PAAPASA-DAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATA 2166
P A D A S P+P AP + + +P + + T
Sbjct: 859 TTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTP 918
Query: 2167 LPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGG 2221
+ + PE P + ++A++QT + N + + L P AGG
Sbjct: 919 RKMTSTMPELNPTS----RIAEAMLQT----TTRPNQTPNSKLVEVNPKSEDAGG 965
Score = 73.9 bits (180), Expect = 2e-12
Identities = 114/517 (22%), Positives = 178/517 (34%), Gaps = 36/517 (6%)
Query: 1799 PAPRAQPKGTPGPR-ATPRKVAPPCLAQPAAPA-KVPSPGQQRSRSLHRPAKTSELATLS 1856
P P+A+ T GP TP++ P +PA+ K P+P +S P + + T S
Sbjct: 197 PTPKAETT-TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT-TPKEPAPTTTKS 254
Query: 1857 QPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTL 1916
P P K P+ ++ + PA P T++A P A PK PA T
Sbjct: 255 APTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT 313
Query: 1917 LAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVA 1976
+ T + PA P EP P A + P
Sbjct: 314 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKE 371
Query: 1977 SALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAV 2036
A ++ E S + T K +P + + ++ +SA + P+ SP + P
Sbjct: 372 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP-TTTKSAPTTPKEPSPTTTKEPAPTT 430
Query: 2037 FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETV 2096
+ + AP PA P P+ ++PA T E P P+
Sbjct: 431 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK-- 488
Query: 2097 KRYASLPHISVARRPDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIR 2150
K + P P+ P AP + + ++ EP P P+ AAP T
Sbjct: 489 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP----- 543
Query: 2151 DEDVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS 2206
E P + P T +TP++ P G P + T + APK + T+
Sbjct: 544 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 603
Query: 2207 ---PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGS 2263
P+ T + P + P+ K P AP +G PA
Sbjct: 604 TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEP--APTTPKGTAPTTLKEPA----- 656
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P+ + P P+ T+ ++ + AP T T
Sbjct: 657 PTTPKKPAPKELAPT-TTKGPTSTTSDKPAPTTPKET 692
Score = 60.5 bits (145), Expect = 2e-08
Identities = 112/503 (22%), Positives = 170/503 (33%), Gaps = 53/503 (10%)
Query: 1823 LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPA-RLAKTPSSSSSQTSP 1881
LA+P A+ + G + P T+ S P+ TP + A T + T+
Sbjct: 194 LAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 252
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVP---KTPARTLLAKQHKTQRSPVRIPFMQRPAR 1938
S P K P T P P P K PA T T + P ++PA
Sbjct: 253 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT-PKKPAP 311
Query: 1939 RGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFI 1998
P A P+ P E P + + + + + T
Sbjct: 312 TTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 370
Query: 1999 KESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPAR 2058
+ +P + S + E A + + A PA + +E + PAP
Sbjct: 371 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 430
Query: 2059 QRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA-SLPHISVARRPDGAVPA 2117
+ PA P+ ++PA TT + P+ + PA P T K+ A + P P P
Sbjct: 431 PKEPA--PTTPKKPA-PTTPKEPAPTTPKEPA--PTTTKKPAPTTPKEPAPTTPKETAPT 485
Query: 2118 -----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRG 2171
P + + ++ +P P P AP T +E P P T
Sbjct: 486 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP-----EEPTPTTPEEPAPTTPKAAAP 540
Query: 2172 STPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP----PGAPAGGQL 2223
+TP++ P P P + T + AP T T+P+ +EP P PA +L
Sbjct: 541 NTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT-TLKEPAPTTPKKPAPKEL 599
Query: 2224 SLLGSDVDGPSLAKAPIS------APFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVP 2277
+ P+ K P S AP +G PA +P A P P
Sbjct: 600 A--------PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT--TPKEPAPTTPKGTAP 649
Query: 2278 SPMVVAATT----DSAAEKAPAT 2296
+ + A T + E AP T
Sbjct: 650 TTLKEPAPTTPKKPAPKELAPTT 672
Score = 55.8 bits (133), Expect = 5e-07
Identities = 140/666 (21%), Positives = 216/666 (32%), Gaps = 99/666 (14%)
Query: 1325 PAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQ 1384
PAPT P +E P +K A P P P PAP +
Sbjct: 333 PAPTTKEPAPTTPKE----------PAPTAPKKPA----PTTPKEPAPTTPKEPAPTTTK 378
Query: 1385 EDDSCTDSAEGTPVNFSSAASLSDE-----TLQGPPRDQPGGPAGRQRPTGRPTSARQAM 1439
E S T E P SA + + E T P + P + P PT+ ++
Sbjct: 379 EP-SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 435
Query: 1440 GHRHKAGGAGRSAEQSRGAGKNRAGL--ELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
K E + K A + P P PA + T + L
Sbjct: 436 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLT 491
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQG---RKEAP-APSK 1553
TTP + A + E+P P T P T E P + AP P +
Sbjct: 492 PTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 545
Query: 1554 AAPAAPP-PARTQPSLIADETP----PCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTK 1608
AP P PA T P A TP P ++ ++L EP P+ P P+ P TK
Sbjct: 546 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 605
Query: 1609 DP--------------GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
+P G P+P +E P + +KP
Sbjct: 606 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 665
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
L + +G + SD+ + E A T + A T E +
Sbjct: 666 KEL-----APTTTKGPTSTTSDKPAPTTPKE-TAPTTPKEPAPTTPKKPAPTTPETPPPT 719
Query: 1715 DSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
S +S + +T+ H+ ++ E+ + P+ SP+ P P
Sbjct: 720 TSEVSTPTTTKEPTTI----HKSPDESTPELSAEPTPK-------ALENSPKEPGVP-TT 767
Query: 1775 RGTQKTTPGVPAVLRGRTV---IYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAK 1831
+ T P + + +T + A PK T T K + A +
Sbjct: 768 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT--ATTTQ 825
Query: 1832 VPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRP 1891
V S Q + P K + L T + P+ T KT +++ P P+ R
Sbjct: 826 VTSTTTQDT----TPFKITTLKTTTLAPKVTT----TKKTITTTEIMNKPEETAKPKDRA 877
Query: 1892 PVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPP-PLARAVPE 1950
++A +P P+ P T K+ + + P +P +++P P + +PE
Sbjct: 878 TNSKA--------TTPKPQKP--TKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPE 927
Query: 1951 PGPRGR 1956
P R
Sbjct: 928 LNPTSR 933
Score = 54.7 bits (130), Expect = 1e-06
Identities = 121/540 (22%), Positives = 181/540 (33%), Gaps = 61/540 (11%)
Query: 1370 PVPVYMLVPAPAPAQEDDSCT--DSAEGTPVNFSSAA--SLSDETLQGPPRDQPG--GPA 1423
P P PAP +E T ++A TP + L+ T + P P P
Sbjct: 458 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 517
Query: 1424 GRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSK 1483
+ PT PT+ + KA E + K A P P+ P + +
Sbjct: 518 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT-PKEPAPTTPKETAPTT 574
Query: 1484 PGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQ 1543
P T L+ TTP + A P APT T TS T ++P
Sbjct: 575 PKGT-APTTLKEPAPTTPKKPA------------PKELAPTTTKEPTST-----TCDKP- 615
Query: 1544 GRKEAPA-PSKAAPAAPP-PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRG 1601
AP P AP P PA T P A TP ++ ++L EP P+ P P+
Sbjct: 616 ----APTTPKGTAPTTPKEPAPTTPKEPAPTTPK----GTAPTTLKEPAPTTPKKPAPKE 667
Query: 1602 REPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERP 1661
P TK GP P+P +E P + P T +
Sbjct: 668 LAPTTTK--GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 725
Query: 1662 AEGSRERGEEAAGSDRASDLDSVE--WRAIQEGAN--SIVTWLHQAAAATREASSESDSI 1717
++E D ++ S E +A++ + T AA ++ D
Sbjct: 726 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKT 785
Query: 1718 LSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGT 1777
+ +T PK K E + K A + + + + P K T
Sbjct: 786 TERDLRTTPETTTAAPKMTKETATTTEKTT---ESKITATTTQVTSTTTQDTTPFKIT-T 841
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS--- 1834
KTT P V + I + + P RAT K P +P K P+
Sbjct: 842 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 901
Query: 1835 -----PGQQRSRSLHRPAK-TSELATLSQPPRSA----TPPARLAKTPSSSSSQTSPASQ 1884
P ++ ++ P K TS + L+ R A R +TP+S + +P S+
Sbjct: 902 KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 961
>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
Length = 1311
Score = 82.4 bits (202), Expect = 5e-15
Identities = 128/577 (22%), Positives = 195/577 (33%), Gaps = 55/577 (9%)
Query: 1764 SPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCL 1823
+P+ P P P+ TTP P T+ P+ P T TP++ AP
Sbjct: 253 TPKEPT-PTTPKEPASTTPKEPTPT---TIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTT 308
Query: 1824 AQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPA 1882
+PA K P+P + + P T T + P TP TP + T
Sbjct: 309 KEPAPTTPKEPAPTTTKEPA---PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKE 365
Query: 1883 SQPLPRKRPPVT--QAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRG 1940
P K P T + A P A PK PA T + T + P+
Sbjct: 366 PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTT 425
Query: 1941 P----PPLARAVP----EPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFR 1992
P P ++ P EP P T++ P A ++ E + + +
Sbjct: 426 PKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKK 482
Query: 1993 RQLTFIKE-SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPR 2051
T KE +P + + ++ + A + P+ +P + P + + AP
Sbjct: 483 PAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 542
Query: 2052 QGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASL----PHISV 2107
PA P P+ E P TT E P+ P AA P T K A P +
Sbjct: 543 TPEKPAPTTPEELAPTTPEEPT-PTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEPAPTT 599
Query: 2108 ARRPDGAVP--AAPASADAARRSSDGEP------RPLPRVAAPGTTWRRIR---DEDVPH 2156
+ P P AP + ++ EP +P P+ AP TT D+ P
Sbjct: 600 PKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPT 659
Query: 2157 ILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS---PSL 2209
+ T P T +TP++ P G P + T + APK + T+ P+
Sbjct: 660 TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTS 719
Query: 2210 ETREPPGAPAGGQLSLLGSDVDGPSLAKAPISA------PFVHEGLGVAVGGFPASRHGS 2263
T + P + + P+ K P P E P + H S
Sbjct: 720 TTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKS 779
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P S P + P+P + + T +AT
Sbjct: 780 PDES--TPELSAEPTPKALENSPKEPGVPTTKTPAAT 814
Score = 80.1 bits (196), Expect = 2e-14
Identities = 164/772 (21%), Positives = 260/772 (33%), Gaps = 126/772 (16%)
Query: 1380 PAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG----RPTSA 1435
PAP + T E P A + + +P + PT PT+
Sbjct: 288 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 347
Query: 1436 RQAMGHRHKAGGAGRSAEQSRGAGKNRAGL-ELPLGRPPSAPADKDGSKPGRTRGDGALQ 1494
++ K E + K A + P P PA KP T
Sbjct: 348 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------- 400
Query: 1495 SLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR----AFTRERPQGRKE-AP 1549
TP E A P APT T + P+ T+ P KE AP
Sbjct: 401 -----TPKEPA---------PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 446
Query: 1550 APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKD 1609
+K+AP P + T P ++ + P EP P+ P TK
Sbjct: 447 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 506
Query: 1610 PGPGGGRDSSP-SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDE----RPAEG 1664
P P ++ +P +P+ + ++ P + P + KP T +E P E
Sbjct: 507 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT---PEKPAPTTPEELAPTTPEEP 563
Query: 1665 SRERGEE-AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
+ EE A + +A+ ++ + A T + A T + ++ + G
Sbjct: 564 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-----KG 618
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPG 1783
+ + +P + A E+ E TS + PA P P+GT TTP
Sbjct: 619 TAPTTLKEPAPTTPKKPAPKELAPTTTKE-------PTSTTCDKPA-PTTPKGTAPTTPK 670
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGT-------PGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
PA + PAP PKGT P P TP+K AP + AP P
Sbjct: 671 EPAPTTPK------EPAP-TTPKGTAPTTLKEPAP-TTPKKPAP----KELAPTTTKGP- 717
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRS---ATPPARLAKTPSSSSSQTSPASQPLPRKRPPV 1893
S + +PA T+ T P+ TP TP + TS S P K P
Sbjct: 718 --TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 775
Query: 1894 TQAA--GALPGPGASPVPKTPARTLLAKQHKTQRSPVRI-PFMQRPAR--------RGPP 1942
+ + P A P PK + T ++P P M A+ R P
Sbjct: 776 IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP 835
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE-- 2000
A P+ TE ++ + + + + + D + F+ +T +K
Sbjct: 836 ETTTAAPKMTKETATTTEKTTESK------ITATTTQVTSTTTQDTTPFK--ITTLKTTT 887
Query: 2001 -SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQ 2059
+P + + +++ E + A P+ RA + P Q
Sbjct: 888 LAPKVTTTKKTITTTEIMNKPEETAKPKD------------------RATNSKATTPKPQ 929
Query: 2060 RPPAARPSPGERPARRTTSESPSRLP-VRAPAARPETVKRYASLPHISVARR 2110
+P A P + T+++ P +P VR P P K +++P ++ R
Sbjct: 930 KPTKA-------PKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSR 974
Score = 78.6 bits (192), Expect = 7e-14
Identities = 153/779 (19%), Positives = 252/779 (32%), Gaps = 93/779 (11%)
Query: 1468 PLGRPPSAPADKDGSKPGR--TRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTP 1525
P+ PS P + D SK + +++ TT ++ D E+ +A T
Sbjct: 164 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQT-----STDGKEKTTSAKETQ 218
Query: 1526 THRRTSA-----IPRAFTRERPQGRKEAPAPSKAAPAAPPPART-QPSLIADETPPCYSL 1579
+ +TSA + + P+ P+ P P P +P+ + P ++
Sbjct: 219 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 278
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S+ ++ EP P+ + +EPA T P P+P +E SA
Sbjct: 279 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 338
Query: 1640 RRPPVSGLRRRKPRATRLDE----RPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695
+ P +KP T E P E + +E A + + + + A
Sbjct: 339 PKEPAP-TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKP 397
Query: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG 1755
T + A T + + + +T +P A SA K
Sbjct: 398 APTTPKEPAPTTPKEPAPT-------------TTKEPSPTTPKEPAPTTTKSAPTTTKEP 444
Query: 1756 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP 1815
A + T +P +P P P T++ P P PAP K P TP
Sbjct: 445 APTT-TKSAPTTPKEPS-PTTTKEPAPTTPK-----------EPAPTTPKKPAP---TTP 488
Query: 1816 RKVAPPCLAQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
++ AP +PA K P+P T + P TP TP
Sbjct: 489 KEPAPTTPKEPAPTTTKKPAP------------------TTPKEPAPTTPKETAPTTPKK 530
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPAR----TLLAKQHKTQRSPVRI 1930
+ T P ++P T P P P TP T A T + P
Sbjct: 531 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 590
Query: 1931 PFMQRPARRGPPPLARAVPE----PGPRGRAGTE-AGPGARGGRLGLVRVASALSSGSES 1985
+ PA P A P+ P+G A T P + + + ++ +
Sbjct: 591 T-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 649
Query: 1986 SDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEE 2045
S T +P + + + E A + P+G +P + P +E
Sbjct: 650 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT-PKKPAPKE 708
Query: 2046 LRAAPRQGPA------PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
L +GP PA P P+ + PA T + P P E
Sbjct: 709 LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 768
Query: 2100 ASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILR 2159
+ ++ + PD + P SA+ ++ + P+ PG + P +
Sbjct: 769 TTKEPTTIHKSPDESTP--ELSAEPTPKALENSPK------EPGVPTTKTPAATKPEMTT 820
Query: 2160 STLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
+ T +TPE A P+ T + TE+ K ++T+ T P
Sbjct: 821 TAKDKTTERDLRTTPETTTAA--PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 877
Score = 77.8 bits (190), Expect = 1e-13
Identities = 159/775 (20%), Positives = 249/775 (32%), Gaps = 100/775 (12%)
Query: 1468 PLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH 1527
P P PA +P T A TTP E A + ++P P
Sbjct: 311 PAPTTPKEPAPTTTKEPAPTTTKSAP-----TTPKEPAP------TTPKKPAPTTPKEPA 359
Query: 1528 RRTSAIPRAFTRERPQGRKEAPAPS---KAAPAAPP-PARTQPSLIADETPPCYSLSSSA 1583
T P T + P + PAP+ + AP AP PA T P A TP +
Sbjct: 360 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK----EPAP 415
Query: 1584 SSLSEPEPSEP--PAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRR 1641
++ EP P+ P PA P TK+P P + + +P+ + + P+
Sbjct: 416 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 475
Query: 1642 PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLH 1701
P + +KP T P E + +E A + + T
Sbjct: 476 APTTP---KKPAPTT----PKEPAPTTPKEPAPTTTKKPAPT--------------TPKE 514
Query: 1702 QAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKT 1761
A +E + + L+ + L P K E + PE+ T
Sbjct: 515 PAPTTPKETAPTTPKKLT----PTTPEKLAPTTPEKPAPTTPEELAPTTPEE------PT 564
Query: 1762 SGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPP 1821
+P PA P P+ TP PA T P+P +P T TP++ AP
Sbjct: 565 PTTPEEPA-PTTPKAAAPNTPKEPAP----TTPKEPAPTTPKEPAPT-----TPKETAPT 614
Query: 1822 CLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSP 1881
+ AP + P + +PA T ++ P S T TP ++ T
Sbjct: 615 T-PKGTAPTTLKEPAPTTPK---KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 670
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP 1941
P K P T G P P P TP + + T +PA P
Sbjct: 671 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTP 730
Query: 1942 PPLARAVP-EPGP----RGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLT 1996
A P EP P + T P + ++ +S D S
Sbjct: 731 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES------- 783
Query: 1997 FIKESPGLRRRRSE--LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP 2054
+P L + L ++ P +P +P + + +LR P
Sbjct: 784 ----TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 839
Query: 2055 APARQRPPAARPSPG--ERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPD 2112
A + A + E TT++ S + T+K P ++ ++
Sbjct: 840 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTI 899
Query: 2113 GAV-----PAAPASA-DAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATA 2166
P A D A S P+P AP + + +P + + T
Sbjct: 900 TTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTP 959
Query: 2167 LPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGG 2221
+ + PE P + ++A++QT + N + + L P AGG
Sbjct: 960 RKMTSTMPELNPTS----RIAEAMLQT----TTRPNQTPNSKLVEVNPKSEDAGG 1006
Score = 73.9 bits (180), Expect = 2e-12
Identities = 114/517 (22%), Positives = 178/517 (34%), Gaps = 36/517 (6%)
Query: 1799 PAPRAQPKGTPGPR-ATPRKVAPPCLAQPAAPA-KVPSPGQQRSRSLHRPAKTSELATLS 1856
P P+A+ T GP TP++ P +PA+ K P+P +S P + + T S
Sbjct: 238 PTPKAETT-TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT-TPKEPAPTTTKS 295
Query: 1857 QPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTL 1916
P P K P+ ++ + PA P T++A P A PK PA T
Sbjct: 296 APTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT 354
Query: 1917 LAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVA 1976
+ T + PA P EP P A + P
Sbjct: 355 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKE 412
Query: 1977 SALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAV 2036
A ++ E S + T K +P + + ++ +SA + P+ SP + P
Sbjct: 413 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP-TTTKSAPTTPKEPSPTTTKEPAPTT 471
Query: 2037 FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETV 2096
+ + AP PA P P+ ++PA T E P P+
Sbjct: 472 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK-- 529
Query: 2097 KRYASLPHISVARRPDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIR 2150
K + P P+ P AP + + ++ EP P P+ AAP T
Sbjct: 530 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP----- 584
Query: 2151 DEDVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS 2206
E P + P T +TP++ P G P + T + APK + T+
Sbjct: 585 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 644
Query: 2207 ---PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGS 2263
P+ T + P + P+ K P AP +G PA
Sbjct: 645 TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEP--APTTPKGTAPTTLKEPA----- 697
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P+ + P P+ T+ ++ + AP T T
Sbjct: 698 PTTPKKPAPKELAPT-TTKGPTSTTSDKPAPTTPKET 733
Score = 60.5 bits (145), Expect = 2e-08
Identities = 112/503 (22%), Positives = 170/503 (33%), Gaps = 53/503 (10%)
Query: 1823 LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPA-RLAKTPSSSSSQTSP 1881
LA+P A+ + G + P T+ S P+ TP + A T + T+
Sbjct: 235 LAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTT 293
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVP---KTPARTLLAKQHKTQRSPVRIPFMQRPAR 1938
S P K P T P P P K PA T T + P ++PA
Sbjct: 294 KSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT-PKKPAP 352
Query: 1939 RGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFI 1998
P A P+ P E P + + + + + T
Sbjct: 353 TTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK 411
Query: 1999 KESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPAR 2058
+ +P + S + E A + + A PA + +E + PAP
Sbjct: 412 EPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTT 471
Query: 2059 QRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA-SLPHISVARRPDGAVPA 2117
+ PA P+ ++PA TT + P+ + PA P T K+ A + P P P
Sbjct: 472 PKEPA--PTTPKKPA-PTTPKEPAPTTPKEPA--PTTTKKPAPTTPKEPAPTTPKETAPT 526
Query: 2118 -----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRG 2171
P + + ++ +P P P AP T +E P P T
Sbjct: 527 TPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP-----EEPTPTTPEEPAPTTPKAAAP 581
Query: 2172 STPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP----PGAPAGGQL 2223
+TP++ P P P + T + AP T T+P+ +EP P PA +L
Sbjct: 582 NTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT-TLKEPAPTTPKKPAPKEL 640
Query: 2224 SLLGSDVDGPSLAKAPIS------APFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVP 2277
+ P+ K P S AP +G PA +P A P P
Sbjct: 641 A--------PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT--TPKEPAPTTPKGTAP 690
Query: 2278 SPMVVAATT----DSAAEKAPAT 2296
+ + A T + E AP T
Sbjct: 691 TTLKEPAPTTPKKPAPKELAPTT 713
Score = 55.8 bits (133), Expect = 5e-07
Identities = 140/666 (21%), Positives = 216/666 (32%), Gaps = 99/666 (14%)
Query: 1325 PAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQ 1384
PAPT P +E P +K A P P P PAP +
Sbjct: 374 PAPTTKEPAPTTPKE----------PAPTAPKKPA----PTTPKEPAPTTPKEPAPTTTK 419
Query: 1385 EDDSCTDSAEGTPVNFSSAASLSDE-----TLQGPPRDQPGGPAGRQRPTGRPTSARQAM 1439
E S T E P SA + + E T P + P + P PT+ ++
Sbjct: 420 EP-SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 476
Query: 1440 GHRHKAGGAGRSAEQSRGAGKNRAGL--ELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
K E + K A + P P PA + T + L
Sbjct: 477 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLT 532
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQG---RKEAP-APSK 1553
TTP + A + E+P P T P T E P + AP P +
Sbjct: 533 PTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 586
Query: 1554 AAPAAPP-PARTQPSLIADETP----PCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTK 1608
AP P PA T P A TP P ++ ++L EP P+ P P+ P TK
Sbjct: 587 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 646
Query: 1609 DP--------------GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
+P G P+P +E P + +KP
Sbjct: 647 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 706
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
L + +G + SD+ + E A T + A T E +
Sbjct: 707 KEL-----APTTTKGPTSTTSDKPAPTTPKE-TAPTTPKEPAPTTPKKPAPTTPETPPPT 760
Query: 1715 DSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
S +S + +T+ H+ ++ E+ + P+ SP+ P P
Sbjct: 761 TSEVSTPTTTKEPTTI----HKSPDESTPELSAEPTPK-------ALENSPKEPGVP-TT 808
Query: 1775 RGTQKTTPGVPAVLRGRTV---IYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAK 1831
+ T P + + +T + A PK T T K + A +
Sbjct: 809 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT--ATTTQ 866
Query: 1832 VPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRP 1891
V S Q + P K + L T + P+ T KT +++ P P+ R
Sbjct: 867 VTSTTTQDT----TPFKITTLKTTTLAPKVTT----TKKTITTTEIMNKPEETAKPKDRA 918
Query: 1892 PVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPP-PLARAVPE 1950
++A +P P+ P T K+ + + P +P +++P P + +PE
Sbjct: 919 TNSKA--------TTPKPQKP--TKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPE 968
Query: 1951 PGPRGR 1956
P R
Sbjct: 969 LNPTSR 974
Score = 54.7 bits (130), Expect = 1e-06
Identities = 121/540 (22%), Positives = 181/540 (33%), Gaps = 61/540 (11%)
Query: 1370 PVPVYMLVPAPAPAQEDDSCT--DSAEGTPVNFSSAA--SLSDETLQGPPRDQPG--GPA 1423
P P PAP +E T ++A TP + L+ T + P P P
Sbjct: 499 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 558
Query: 1424 GRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSK 1483
+ PT PT+ + KA E + K A P P+ P + +
Sbjct: 559 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT-PKEPAPTTPKETAPTT 615
Query: 1484 PGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQ 1543
P T L+ TTP + A P APT T TS T ++P
Sbjct: 616 PKGT-APTTLKEPAPTTPKKPA------------PKELAPTTTKEPTST-----TCDKP- 656
Query: 1544 GRKEAPA-PSKAAPAAPP-PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRG 1601
AP P AP P PA T P A TP ++ ++L EP P+ P P+
Sbjct: 657 ----APTTPKGTAPTTPKEPAPTTPKEPAPTTPK----GTAPTTLKEPAPTTPKKPAPKE 708
Query: 1602 REPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERP 1661
P TK GP P+P +E P + P T +
Sbjct: 709 LAPTTTK--GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 766
Query: 1662 AEGSRERGEEAAGSDRASDLDSVE--WRAIQEGAN--SIVTWLHQAAAATREASSESDSI 1717
++E D ++ S E +A++ + T AA ++ D
Sbjct: 767 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKT 826
Query: 1718 LSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGT 1777
+ +T PK K E + K A + + + + P K T
Sbjct: 827 TERDLRTTPETTTAAPKMTKETATTTEKTT---ESKITATTTQVTSTTTQDTTPFKIT-T 882
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS--- 1834
KTT P V + I + + P RAT K P +P K P+
Sbjct: 883 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 942
Query: 1835 -----PGQQRSRSLHRPAK-TSELATLSQPPRSA----TPPARLAKTPSSSSSQTSPASQ 1884
P ++ ++ P K TS + L+ R A R +TP+S + +P S+
Sbjct: 943 KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1002
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 82.4 bits (202), Expect = 5e-15
Identities = 183/827 (22%), Positives = 297/827 (35%), Gaps = 129/827 (15%)
Query: 1520 AAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSL 1579
+ A +P+H +AIP + Q +E + A +R Q L PP +
Sbjct: 27 SGAGSPSH---TAIPAGMEADLSQLSEE-----ERRQIAAVMSRAQ-GLPKGSVPPAAAE 77
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S S E + S PP GR P + PG + + +E+ LP
Sbjct: 78 SPSMHRKQELDSSHPP--KQSGRPPDPGRPAQPGLSKSRTTDTFRSEQ--------KLPG 127
Query: 1640 RRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVE-WRAIQEGANSIVT 1698
R P L+ K R + EE S L V A+ N
Sbjct: 128 RSPSTISLKESKSRT------------DLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNP 175
Query: 1699 W-LHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAA 1757
+ L + A++E +++ ++ G G P + + + + G R P
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDP------ 229
Query: 1758 SVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRT--------VIYVPSPAPRAQPKGTP 1809
++ G+P+S ++P + PG ++G T + + A R Q K
Sbjct: 230 -LQQDGTPKS-ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQAD 287
Query: 1810 GPRATPRKVAPPCLAQP----AAPAKVPS--PGQQRSR--SLHRPAKTSELA-TLSQPPR 1860
R K + P ++P P K P+ PG ++S+ PA+ S L L+Q P
Sbjct: 288 IVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG 347
Query: 1861 SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQA-----AGALPGPGASPVP----KT 1911
+ PP + T T P +QPL +PP Q + PGP A P KT
Sbjct: 348 TVKPPVQPPGT-------TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKT 400
Query: 1912 PARTLLAKQHKTQRSPVRIPFMQRPA----RRGPPPLARAVPEPGPRGRAGTEAGPGARG 1967
PA+ + TQ+ P Q+P + P P V +PGP +AGPG
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460
Query: 1968 G-RLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASP 2026
+ G + S L ++ + + + PG + S+ S PQ P
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQ--QPGSTKPPPQQPGP 516
Query: 2027 RRGRPALPAVFLCSSRCEELRAAPRQGPA---PARQRPPAARPSPGE--RPARRTTSESP 2081
+ P P P Q P P+ Q+P A+PS + +P +T S P
Sbjct: 517 AKPSPQQPG----------STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 566
Query: 2082 SRLPVRAPAAR-------PETVKRYAS----LPHISVARRPDGAVPAAPASADAARRSSD 2130
+ P +P+A+ P+T+ + L H+ + + +
Sbjct: 567 LQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPN 626
Query: 2131 GEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAV 2190
+ +R D+ + S P +T + + P P++TS
Sbjct: 627 PHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS--- 683
Query: 2191 VQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLG 2250
++ AAPK + S +P E ++PP P Q +L GS + AK P A + +
Sbjct: 684 --PKKDAAPKQDLSKAP--EPKKPP--PLVKQPTLHGSP---SAKAKQPPEADSLSKPA- 733
Query: 2251 VAVGGFPASRHGSPSRSARVPPFNYVP-SPMVVAATTDSAAEKAPAT 2296
P PS + P + P P +V TTD + + T
Sbjct: 734 ------PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Score = 72.4 bits (176), Expect = 5e-12
Identities = 201/925 (21%), Positives = 299/925 (32%), Gaps = 203/925 (21%)
Query: 1298 PSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRK 1357
PS P + G GH + + GPA ++P G L + G P
Sbjct: 301 PSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKP----LAQQPGTVKPP---- 352
Query: 1358 VASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGT-PVNFSSAASLSDETLQGPPR 1416
+ P P P L PA PAQ+ S S+E P + + Q P
Sbjct: 353 ----VQPPGTTKP-PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPG- 406
Query: 1417 DQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAP 1476
P P +Q T +P + + + KA G ++ Q G GK P
Sbjct: 407 --PAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGK--------------IP 450
Query: 1477 ADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRA 1536
A + G PG+T S T PT+ PP+ P P
Sbjct: 451 AQQAG--PGKT-------SAQQTGPTK--------------PPSQLPGPAK--------- 478
Query: 1537 FTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPA 1596
P P + PA PPP QP PP S ++P P +P
Sbjct: 479 ------------PPPQQPGPAKPPPQ--QPG---SAKPP-----SQQPGSTKPPPQQPGP 516
Query: 1597 VHPRGREPAVTKDPG--PGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
P ++P TK P PG + S+ P A+ Q+ PVS KP
Sbjct: 517 AKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTK--------PVSQTGSGKPLQ 568
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
A+ +G + I N+ LH A +E
Sbjct: 569 PPTVSPSAKQPPSQGLP---------------KTICPLCNTTELLLHVPEKANFNTCTEC 613
Query: 1715 DSILSFVSGLSVGSTLQPPKH------RKGRQAEGEMG---SARRPEKRGAASVKTSG-- 1763
+ + + G + L K + R G++ S+ +P+ + A TS
Sbjct: 614 QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVS 673
Query: 1764 ---------SPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRAT 1814
SP+ A P++ P +++ T+ PS + P+ +
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 1815 PRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATL----------SQPPRSATP 1864
P K Q AP P Q + +S AT SQ TP
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793
Query: 1865 PARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGA-SPVPKTPARTLLAKQHKT 1923
P KT S+ SQ+ P P K P A +P P + S + P + +K K
Sbjct: 794 PL---KTDSAKPSQSFP---PTGEKVSPFDSKA--IPRPASDSKIISHPGPSSESKGQK- 844
Query: 1924 QRSPVRIPFMQRPA--RRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSS 1981
Q PV+ + A + P P A+ +P+ P T GP G+ V + S
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSP-----TPPGPRPTAGQT----VPTPQQS 895
Query: 1982 GSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSS 2041
F L I ++P +S + PQ + ++F S
Sbjct: 896 PKPQEQSRRFSLNLGSITDAP------------KSQPTTPQETVTGKLFGFGASIF---S 940
Query: 2042 RCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYAS 2101
+ L + Q P P Q P A P++ TS+ P + +AP A
Sbjct: 941 QASNLISTAGQ-PGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA---------- 989
Query: 2102 LPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRST 2161
P S+ + + PAA EP+ A T +R E P ++ +
Sbjct: 990 -PAKSIPVKKETKAPAAEKL----------EPK-----AEQAPTVKRTETEKKPPPIKDS 1033
Query: 2162 LPATALPLRGSTPEDAPAGPPPRKT 2186
TA P + P P P T
Sbjct: 1034 KSLTAEPQKAVLPTKLEKSPKPEST 1058
Score = 67.8 bits (164), Expect = 1e-10
Identities = 108/476 (22%), Positives = 155/476 (32%), Gaps = 105/476 (22%)
Query: 1459 GKNRAGLELPLGRPPSAPADKDGSKPGRT--RGDGALQSLCLTTPTEEAVYCFYGNDSDE 1516
GK ++ PL + P P K PGR + DG +S+ P E+ G
Sbjct: 201 GKPEGIIKPPLQQQPPKPIPKQQG-PGRDPLQQDGTPKSISSQQP-EKIKSQPPGTGKPI 258
Query: 1517 EPPAAAPTPTHRRTSAIPRAFTRERPQGRK------EAPAPSKAAPAAPPPARTQPSLIA 1570
+ P P H + +P RPQ ++ E+ PS +P+ PP
Sbjct: 259 QGPTQTPQTDHAK---LPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---------- 305
Query: 1571 DETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQ 1630
+ +P P +PPA P G E + PGP P A L
Sbjct: 306 ---------------IQQPTPGKPPAQQP-GHEKS---QPGPA-------KPPAQPSGLT 339
Query: 1631 RCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQ 1690
+ ++ +PPV KP A L G + + GS++ S + Q
Sbjct: 340 KPLAQQPGTVKPPVQPPGTTKPPAQPL------GPAKPPAQQTGSEKPS--------SEQ 385
Query: 1691 EGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARR 1750
G ++ QPP G+ + G A+
Sbjct: 386 PGPKALA---------------------------------QPP--GVGKTPAQQPGPAKP 410
Query: 1751 PEKRGAASVKTSGSP--RSPAGPEKPRGTQKTTPG---VPAVLRGRTVIYVPSPAPRAQP 1805
P ++ + P +SPA P T PG +PA G P P
Sbjct: 411 PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 470
Query: 1806 KGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPP 1865
PGP P + P P P P QQ + P + Q P S PP
Sbjct: 471 SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 530
Query: 1866 ARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALP--GPGASPVPKTPARTLLAK 1919
++ + S+ Q SPA + PV+Q P P SP K P L K
Sbjct: 531 SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586
Score = 46.2 bits (108), Expect = 4e-04
Identities = 120/580 (20%), Positives = 197/580 (33%), Gaps = 72/580 (12%)
Query: 1751 PEKRGAASVKTSGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGT 1808
PE AA+ G+ SP+ P G + + R R + V S A + PKG+
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEER-RQIAAVMSRA-QGLPKGS 70
Query: 1809 PGPRATP-----RKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSAT 1863
P A RK P + P PG+ L + T + + P +
Sbjct: 71 VPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP 130
Query: 1864 PPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKT 1923
L ++ S + + S +P V + +S V K L++ +
Sbjct: 131 STISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEAS 185
Query: 1924 QRSPVRIPFMQRPARRGP-----PPLARAVPEPGPRGRAGTEAGPGARGGRL-GLVRVAS 1977
Q + + + + P PPL + P+P P+ + GPG + G + S
Sbjct: 186 QEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK-----QQGPGRDPLQQDGTPKSIS 240
Query: 1978 ALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVF 2037
+ S G + + ++P + L S Q A RG P++
Sbjct: 241 SQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQ-ADIVRGESVKPSL- 298
Query: 2038 LCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVK 2097
P+ +PP +P+PG+ PA++ E P + PA K
Sbjct: 299 ------------------PSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTK 340
Query: 2098 RYASLP-HISVARRPDG-----AVPAAPASADAARRSSD--GEPRPLPR-VAAPGTTWRR 2148
A P + +P G A P PA A + S+ +P P+ +A P +
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKT 400
Query: 2149 IRDEDVPHILRSTLPATALPLRGSTPEDAPA-GPPPRKT-----SDAVVQTEEVAAPKTN 2202
+ P + T PL +PA P P KT + ++ KT+
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460
Query: 2203 S-STSPSLETREPPG--APAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPAS 2259
+ T P+ + PG P Q P AK P P + P
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTK---------PPP 511
Query: 2260 RHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASA 2299
+ P++ + P + P + SA + +PA SA
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSA 551
Score = 38.9 bits (89), Expect = 0.059
Identities = 69/298 (23%), Positives = 104/298 (34%), Gaps = 55/298 (18%)
Query: 938 PREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSP 997
P+ PL ASR + + R + LP ++PP ++ T P
Sbjct: 265 PQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS-PSKPPIQQPTPGKP--------P 315
Query: 998 TYQHVPLLEGASRAGAEPLAGPG--ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKAL 1055
Q P E + A+P A P P A++ + K A PL A
Sbjct: 316 AQQ--PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPA 373
Query: 1056 QKLAA------QEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAE 1109
Q+ + Q GP +L++ + + A +PGP++ + G + +
Sbjct: 374 QQTGSEKPSSEQPGPKALAQPPGVGK-TPAQQPGPAK------PPTQQVGTPKPLAQQPG 426
Query: 1110 LDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLG 1169
L S +APG T PV P P + + + A P +S T
Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGK-----IPAQQAGPGKTSAQQTGPTK------------P 469
Query: 1170 SFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSR----SKTPPLAPAPQGP 1223
+ P A P +P G P P PG PPS+ +K PP P P P
Sbjct: 470 PSQLPGPAKPPPQQP------GPAKPP--PQQPGSAKPPSQQPGSTKPPPQQPGPAKP 519
Score = 36.2 bits (82), Expect = 0.38
Identities = 74/322 (22%), Positives = 111/322 (34%), Gaps = 50/322 (15%)
Query: 2017 AASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRT 2076
A+ P G+ PA P F SS + P P P PP P P P
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPP--P 2430
Query: 2077 TSESPSRLP-VRAPAARPET----------------VKRYASLPHISVARRPDGAVPAAP 2119
TS P+ LP + A P T V R LP + VP P
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKP 2490
Query: 2120 ASADA----ARRSSDGEPRPLPRVAAPGTTWRRIRDEDV---PHILRST----------- 2161
+S + R +P P+ P + D+ P L T
Sbjct: 2491 SSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSA 2550
Query: 2162 ---LPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
LP+ PL + + +P + V+ T+SS S ++ T P G+P
Sbjct: 2551 DYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAI-TSWPLGSP 2609
Query: 2219 AGGQLSL--LGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYV 2276
+ +S+ + S V + + PIS+ G A+ F A+ +PS F
Sbjct: 2610 SKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISG-ALQTFSATPVTAPS------SFQAA 2662
Query: 2277 PSPMVVAATTDSAAEKAPATAS 2298
P+ + TT+ + + AT S
Sbjct: 2663 PTSVTQFLTTEVSKTEVSATRS 2684
Score = 33.5 bits (75), Expect = 2.5
Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 1146 SSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQT 1205
+S E + QE P S L S SPS+ SS+P++P S ++ S P P
Sbjct: 2362 TSGETFGQEKP--------ASQLPS-GSPSV-SSLPAKPRPFFRSSSLDISAQPPPPPPP 2411
Query: 1206 MPPSRSKTPPLAPAPQGPP 1224
PP PP P P PP
Sbjct: 2412 PPPPPPPPPPPPPPPLPPP 2430
Score = 32.0 bits (71), Expect = 7.2
Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 3/76 (3%)
Query: 1856 SQPPRSATPPARLAKTPSS---SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTP 1912
SQ P + + L P SSS A P P PP P P P P +P
Sbjct: 2374 SQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 1913 ARTLLAKQHKTQRSPV 1928
T+L K+ T SPV
Sbjct: 2434 KPTILPKKKLTVASPV 2449
Score = 31.6 bits (70), Expect = 9.4
Identities = 52/228 (22%), Positives = 81/228 (35%), Gaps = 34/228 (14%)
Query: 1679 SDLDSVEWRAIQEGANSIVTWLHQAAAATREASSE--SDSILSFVSGLSVGSTLQPPKHR 1736
S+ D V+ +A +E N I+ + +A +E +E S+ V S + P
Sbjct: 2296 SEKDPVK-KAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKE 2354
Query: 1737 KGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYV 1796
+ G EK AS SGSP + P KPR +++ +
Sbjct: 2355 QLSTTYFTSGETFGQEK--PASQLPSGSPSVSSLPAKPRPFFRSS--------SLDISAQ 2404
Query: 1797 PSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLS 1856
P P P P P P P PP L P +P P ++ T++
Sbjct: 2405 PPPPPPPPPPPPPPPPPPP----PPPLPPPTSPKPTILPKKK--------------LTVA 2446
Query: 1857 QPPRSATP---PARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALP 1901
P +ATP +T + S P ++ PPV ++P
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 82.4 bits (202), Expect = 5e-15
Identities = 183/827 (22%), Positives = 297/827 (35%), Gaps = 129/827 (15%)
Query: 1520 AAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSL 1579
+ A +P+H +AIP + Q +E + A +R Q L PP +
Sbjct: 27 SGAGSPSH---TAIPAGMEADLSQLSEE-----ERRQIAAVMSRAQ-GLPKGSVPPAAAE 77
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S S E + S PP GR P + PG + + +E+ LP
Sbjct: 78 SPSMHRKQELDSSHPP--KQSGRPPDPGRPAQPGLSKSRTTDTFRSEQ--------KLPG 127
Query: 1640 RRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVE-WRAIQEGANSIVT 1698
R P L+ K R + EE S L V A+ N
Sbjct: 128 RSPSTISLKESKSRT------------DLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNP 175
Query: 1699 W-LHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAA 1757
+ L + A++E +++ ++ G G P + + + + G R P
Sbjct: 176 FDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDP------ 229
Query: 1758 SVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRT--------VIYVPSPAPRAQPKGTP 1809
++ G+P+S ++P + PG ++G T + + A R Q K
Sbjct: 230 -LQQDGTPKS-ISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQAD 287
Query: 1810 GPRATPRKVAPPCLAQP----AAPAKVPS--PGQQRSR--SLHRPAKTSELA-TLSQPPR 1860
R K + P ++P P K P+ PG ++S+ PA+ S L L+Q P
Sbjct: 288 IVRGESVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPG 347
Query: 1861 SATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQA-----AGALPGPGASPVP----KT 1911
+ PP + T T P +QPL +PP Q + PGP A P KT
Sbjct: 348 TVKPPVQPPGT-------TKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKT 400
Query: 1912 PARTLLAKQHKTQRSPVRIPFMQRPA----RRGPPPLARAVPEPGPRGRAGTEAGPGARG 1967
PA+ + TQ+ P Q+P + P P V +PGP +AGPG
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460
Query: 1968 G-RLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASP 2026
+ G + S L ++ + + + PG + S+ S PQ P
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPP--PQQPGSAKPPSQ--QPGSTKPPPQQPGP 516
Query: 2027 RRGRPALPAVFLCSSRCEELRAAPRQGPA---PARQRPPAARPSPGE--RPARRTTSESP 2081
+ P P P Q P P+ Q+P A+PS + +P +T S P
Sbjct: 517 AKPSPQQPG----------STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKP 566
Query: 2082 SRLPVRAPAAR-------PETVKRYAS----LPHISVARRPDGAVPAAPASADAARRSSD 2130
+ P +P+A+ P+T+ + L H+ + + +
Sbjct: 567 LQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFNPN 626
Query: 2131 GEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAV 2190
+ +R D+ + S P +T + + P P++TS
Sbjct: 627 PHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTS--- 683
Query: 2191 VQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLG 2250
++ AAPK + S +P E ++PP P Q +L GS + AK P A + +
Sbjct: 684 --PKKDAAPKQDLSKAP--EPKKPP--PLVKQPTLHGSP---SAKAKQPPEADSLSKPA- 733
Query: 2251 VAVGGFPASRHGSPSRSARVPPFNYVP-SPMVVAATTDSAAEKAPAT 2296
P PS + P + P P +V TTD + + T
Sbjct: 734 ------PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATT 774
Score = 72.4 bits (176), Expect = 5e-12
Identities = 201/925 (21%), Positives = 299/925 (32%), Gaps = 203/925 (21%)
Query: 1298 PSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRK 1357
PS P + G GH + + GPA ++P G L + G P
Sbjct: 301 PSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKP----LAQQPGTVKPP---- 352
Query: 1358 VASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGT-PVNFSSAASLSDETLQGPPR 1416
+ P P P L PA PAQ+ S S+E P + + Q P
Sbjct: 353 ----VQPPGTTKP-PAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPG- 406
Query: 1417 DQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAP 1476
P P +Q T +P + + + KA G ++ Q G GK P
Sbjct: 407 --PAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGK--------------IP 450
Query: 1477 ADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRA 1536
A + G PG+T S T PT+ PP+ P P
Sbjct: 451 AQQAG--PGKT-------SAQQTGPTK--------------PPSQLPGPAK--------- 478
Query: 1537 FTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPA 1596
P P + PA PPP QP PP S ++P P +P
Sbjct: 479 ------------PPPQQPGPAKPPPQ--QPG---SAKPP-----SQQPGSTKPPPQQPGP 516
Query: 1597 VHPRGREPAVTKDPG--PGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
P ++P TK P PG + S+ P A+ Q+ PVS KP
Sbjct: 517 AKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTK--------PVSQTGSGKPLQ 568
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
A+ +G + I N+ LH A +E
Sbjct: 569 PPTVSPSAKQPPSQGLP---------------KTICPLCNTTELLLHVPEKANFNTCTEC 613
Query: 1715 DSILSFVSGLSVGSTLQPPKH------RKGRQAEGEMG---SARRPEKRGAASVKTSG-- 1763
+ + + G + L K + R G++ S+ +P+ + A TS
Sbjct: 614 QTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVS 673
Query: 1764 ---------SPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRAT 1814
SP+ A P++ P +++ T+ PS + P+ +
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733
Query: 1815 PRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATL----------SQPPRSATP 1864
P K Q AP P Q + +S AT SQ TP
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793
Query: 1865 PARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGA-SPVPKTPARTLLAKQHKT 1923
P KT S+ SQ+ P P K P A +P P + S + P + +K K
Sbjct: 794 PL---KTDSAKPSQSFP---PTGEKVSPFDSKA--IPRPASDSKIISHPGPSSESKGQK- 844
Query: 1924 QRSPVRIPFMQRPA--RRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSS 1981
Q PV+ + A + P P A+ +P+ P T GP G+ V + S
Sbjct: 845 QVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSP-----TPPGPRPTAGQT----VPTPQQS 895
Query: 1982 GSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSS 2041
F L I ++P +S + PQ + ++F S
Sbjct: 896 PKPQEQSRRFSLNLGSITDAP------------KSQPTTPQETVTGKLFGFGASIF---S 940
Query: 2042 RCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYAS 2101
+ L + Q P P Q P A P++ TS+ P + +AP A
Sbjct: 941 QASNLISTAGQ-PGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPA---------- 989
Query: 2102 LPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRST 2161
P S+ + + PAA EP+ A T +R E P ++ +
Sbjct: 990 -PAKSIPVKKETKAPAAEKL----------EPK-----AEQAPTVKRTETEKKPPPIKDS 1033
Query: 2162 LPATALPLRGSTPEDAPAGPPPRKT 2186
TA P + P P P T
Sbjct: 1034 KSLTAEPQKAVLPTKLEKSPKPEST 1058
Score = 67.8 bits (164), Expect = 1e-10
Identities = 108/476 (22%), Positives = 155/476 (32%), Gaps = 105/476 (22%)
Query: 1459 GKNRAGLELPLGRPPSAPADKDGSKPGRT--RGDGALQSLCLTTPTEEAVYCFYGNDSDE 1516
GK ++ PL + P P K PGR + DG +S+ P E+ G
Sbjct: 201 GKPEGIIKPPLQQQPPKPIPKQQG-PGRDPLQQDGTPKSISSQQP-EKIKSQPPGTGKPI 258
Query: 1517 EPPAAAPTPTHRRTSAIPRAFTRERPQGRK------EAPAPSKAAPAAPPPARTQPSLIA 1570
+ P P H + +P RPQ ++ E+ PS +P+ PP
Sbjct: 259 QGPTQTPQTDHAK---LPLQRDASRPQTKQADIVRGESVKPSLPSPSKPP---------- 305
Query: 1571 DETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQ 1630
+ +P P +PPA P G E + PGP P A L
Sbjct: 306 ---------------IQQPTPGKPPAQQP-GHEKS---QPGPA-------KPPAQPSGLT 339
Query: 1631 RCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQ 1690
+ ++ +PPV KP A L G + + GS++ S + Q
Sbjct: 340 KPLAQQPGTVKPPVQPPGTTKPPAQPL------GPAKPPAQQTGSEKPS--------SEQ 385
Query: 1691 EGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARR 1750
G ++ QPP G+ + G A+
Sbjct: 386 PGPKALA---------------------------------QPP--GVGKTPAQQPGPAKP 410
Query: 1751 PEKRGAASVKTSGSP--RSPAGPEKPRGTQKTTPG---VPAVLRGRTVIYVPSPAPRAQP 1805
P ++ + P +SPA P T PG +PA G P P
Sbjct: 411 PTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPP 470
Query: 1806 KGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPP 1865
PGP P + P P P P QQ + P + Q P S PP
Sbjct: 471 SQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPP 530
Query: 1866 ARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALP--GPGASPVPKTPARTLLAK 1919
++ + S+ Q SPA + PV+Q P P SP K P L K
Sbjct: 531 SQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPK 586
Score = 46.2 bits (108), Expect = 4e-04
Identities = 120/580 (20%), Positives = 197/580 (33%), Gaps = 72/580 (12%)
Query: 1751 PEKRGAASVKTSGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGT 1808
PE AA+ G+ SP+ P G + + R R + V S A + PKG+
Sbjct: 13 PEGLAAAAAAGGGASGAGSPSHTAIPAGMEADLSQLSEEER-RQIAAVMSRA-QGLPKGS 70
Query: 1809 PGPRATP-----RKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSAT 1863
P A RK P + P PG+ L + T + + P +
Sbjct: 71 VPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSP 130
Query: 1864 PPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKT 1923
L ++ S + + S +P V + +S V K L++ +
Sbjct: 131 STISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAV-----SSVVNKFNPFDLISDSEAS 185
Query: 1924 QRSPVRIPFMQRPARRGP-----PPLARAVPEPGPRGRAGTEAGPGARGGRL-GLVRVAS 1977
Q + + + + P PPL + P+P P+ + GPG + G + S
Sbjct: 186 QEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK-----QQGPGRDPLQQDGTPKSIS 240
Query: 1978 ALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVF 2037
+ S G + + ++P + L S Q A RG P++
Sbjct: 241 SQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQ-ADIVRGESVKPSL- 298
Query: 2038 LCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVK 2097
P+ +PP +P+PG+ PA++ E P + PA K
Sbjct: 299 ------------------PSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTK 340
Query: 2098 RYASLP-HISVARRPDG-----AVPAAPASADAARRSSD--GEPRPLPR-VAAPGTTWRR 2148
A P + +P G A P PA A + S+ +P P+ +A P +
Sbjct: 341 PLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKT 400
Query: 2149 IRDEDVPHILRSTLPATALPLRGSTPEDAPA-GPPPRKT-----SDAVVQTEEVAAPKTN 2202
+ P + T PL +PA P P KT + ++ KT+
Sbjct: 401 PAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTS 460
Query: 2203 S-STSPSLETREPPG--APAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPAS 2259
+ T P+ + PG P Q P AK P P + P
Sbjct: 461 AQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTK---------PPP 511
Query: 2260 RHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASA 2299
+ P++ + P + P + SA + +PA SA
Sbjct: 512 QQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSA 551
Score = 38.9 bits (89), Expect = 0.059
Identities = 69/298 (23%), Positives = 104/298 (34%), Gaps = 55/298 (18%)
Query: 938 PREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSP 997
P+ PL ASR + + R + LP ++PP ++ T P
Sbjct: 265 PQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPS-PSKPPIQQPTPGKP--------P 315
Query: 998 TYQHVPLLEGASRAGAEPLAGPG--ISPGARKQAWLPADHLSKVPEKLAAAPLSVASKAL 1055
Q P E + A+P A P P A++ + K A PL A
Sbjct: 316 AQQ--PGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPA 373
Query: 1056 QKLAA------QEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAE 1109
Q+ + Q GP +L++ + + A +PGP++ + G + +
Sbjct: 374 QQTGSEKPSSEQPGPKALAQPPGVGK-TPAQQPGPAK------PPTQQVGTPKPLAQQPG 426
Query: 1110 LDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLG 1169
L S +APG T PV P P + + + A P +S T
Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGK-----IPAQQAGPGKTSAQQTGPTK------------P 469
Query: 1170 SFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSR----SKTPPLAPAPQGP 1223
+ P A P +P G P P PG PPS+ +K PP P P P
Sbjct: 470 PSQLPGPAKPPPQQP------GPAKPP--PQQPGSAKPPSQQPGSTKPPPQQPGPAKP 519
Score = 36.2 bits (82), Expect = 0.38
Identities = 74/322 (22%), Positives = 111/322 (34%), Gaps = 50/322 (15%)
Query: 2017 AASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRT 2076
A+ P G+ PA P F SS + P P P PP P P P
Sbjct: 2373 ASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPP--P 2430
Query: 2077 TSESPSRLP-VRAPAARPET----------------VKRYASLPHISVARRPDGAVPAAP 2119
TS P+ LP + A P T V R LP + VP P
Sbjct: 2431 TSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKP 2490
Query: 2120 ASADA----ARRSSDGEPRPLPRVAAPGTTWRRIRDEDV---PHILRST----------- 2161
+S + R +P P+ P + D+ P L T
Sbjct: 2491 SSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLVTSA 2550
Query: 2162 ---LPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
LP+ PL + + +P + V+ T+SS S ++ T P G+P
Sbjct: 2551 DYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPTDSSASQAI-TSWPLGSP 2609
Query: 2219 AGGQLSL--LGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYV 2276
+ +S+ + S V + + PIS+ G A+ F A+ +PS F
Sbjct: 2610 SKDLVSVEPVFSVVPPVTAVEIPISSEQTFYISG-ALQTFSATPVTAPS------SFQAA 2662
Query: 2277 PSPMVVAATTDSAAEKAPATAS 2298
P+ + TT+ + + AT S
Sbjct: 2663 PTSVTQFLTTEVSKTEVSATRS 2684
Score = 33.5 bits (75), Expect = 2.5
Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 10/79 (12%)
Query: 1146 SSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQT 1205
+S E + QE P S L S SPS+ SS+P++P S ++ S P P
Sbjct: 2362 TSGETFGQEKP--------ASQLPS-GSPSV-SSLPAKPRPFFRSSSLDISAQPPPPPPP 2411
Query: 1206 MPPSRSKTPPLAPAPQGPP 1224
PP PP P P PP
Sbjct: 2412 PPPPPPPPPPPPPPPLPPP 2430
Score = 32.0 bits (71), Expect = 7.2
Identities = 25/76 (32%), Positives = 30/76 (39%), Gaps = 3/76 (3%)
Query: 1856 SQPPRSATPPARLAKTPSS---SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTP 1912
SQ P + + L P SSS A P P PP P P P P +P
Sbjct: 2374 SQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433
Query: 1913 ARTLLAKQHKTQRSPV 1928
T+L K+ T SPV
Sbjct: 2434 KPTILPKKKLTVASPV 2449
Score = 31.6 bits (70), Expect = 9.4
Identities = 52/228 (22%), Positives = 81/228 (35%), Gaps = 34/228 (14%)
Query: 1679 SDLDSVEWRAIQEGANSIVTWLHQAAAATREASSE--SDSILSFVSGLSVGSTLQPPKHR 1736
S+ D V+ +A +E N I+ + +A +E +E S+ V S + P
Sbjct: 2296 SEKDPVK-KAKKETGNGIILEVLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKE 2354
Query: 1737 KGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYV 1796
+ G EK AS SGSP + P KPR +++ +
Sbjct: 2355 QLSTTYFTSGETFGQEK--PASQLPSGSPSVSSLPAKPRPFFRSS--------SLDISAQ 2404
Query: 1797 PSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLS 1856
P P P P P P P PP L P +P P ++ T++
Sbjct: 2405 PPPPPPPPPPPPPPPPPPP----PPPLPPPTSPKPTILPKKK--------------LTVA 2446
Query: 1857 QPPRSATP---PARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALP 1901
P +ATP +T + S P ++ PPV ++P
Sbjct: 2447 SPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAPPPVPPKPSSIP 2494
>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
Length = 1363
Score = 80.1 bits (196), Expect = 2e-14
Identities = 164/772 (21%), Positives = 260/772 (33%), Gaps = 126/772 (16%)
Query: 1380 PAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG----RPTSA 1435
PAP + T E P A + + +P + PT PT+
Sbjct: 340 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 399
Query: 1436 RQAMGHRHKAGGAGRSAEQSRGAGKNRAGL-ELPLGRPPSAPADKDGSKPGRTRGDGALQ 1494
++ K E + K A + P P PA KP T
Sbjct: 400 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------- 452
Query: 1495 SLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR----AFTRERPQGRKE-AP 1549
TP E A P APT T + P+ T+ P KE AP
Sbjct: 453 -----TPKEPA---------PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 498
Query: 1550 APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKD 1609
+K+AP P + T P ++ + P EP P+ P TK
Sbjct: 499 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 558
Query: 1610 PGPGGGRDSSP-SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDE----RPAEG 1664
P P ++ +P +P+ + ++ P + P + KP T +E P E
Sbjct: 559 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT---PEKPAPTTPEELAPTTPEEP 615
Query: 1665 SRERGEE-AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
+ EE A + +A+ ++ + A T + A T + ++ + G
Sbjct: 616 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-----KG 670
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPG 1783
+ + +P + A E+ E TS + PA P P+GT TTP
Sbjct: 671 TAPTTLKEPAPTTPKKPAPKELAPTTTKE-------PTSTTCDKPA-PTTPKGTAPTTPK 722
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGT-------PGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
PA + PAP PKGT P P TP+K AP + AP P
Sbjct: 723 EPAPTTPK------EPAP-TTPKGTAPTTLKEPAP-TTPKKPAP----KELAPTTTKGP- 769
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRS---ATPPARLAKTPSSSSSQTSPASQPLPRKRPPV 1893
S + +PA T+ T P+ TP TP + TS S P K P
Sbjct: 770 --TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827
Query: 1894 TQAA--GALPGPGASPVPKTPARTLLAKQHKTQRSPVRI-PFMQRPAR--------RGPP 1942
+ + P A P PK + T ++P P M A+ R P
Sbjct: 828 IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP 887
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE-- 2000
A P+ TE ++ + + + + + D + F+ +T +K
Sbjct: 888 ETTTAAPKMTKETATTTEKTTESK------ITATTTQVTSTTTQDTTPFK--ITTLKTTT 939
Query: 2001 -SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQ 2059
+P + + +++ E + A P+ RA + P Q
Sbjct: 940 LAPKVTTTKKTITTTEIMNKPEETAKPKD------------------RATNSKATTPKPQ 981
Query: 2060 RPPAARPSPGERPARRTTSESPSRLP-VRAPAARPETVKRYASLPHISVARR 2110
+P A P + T+++ P +P VR P P K +++P ++ R
Sbjct: 982 KPTKA-------PKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSR 1026
Score = 78.6 bits (192), Expect = 7e-14
Identities = 153/779 (19%), Positives = 252/779 (32%), Gaps = 93/779 (11%)
Query: 1468 PLGRPPSAPADKDGSKPGR--TRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTP 1525
P+ PS P + D SK + +++ TT ++ D E+ +A T
Sbjct: 216 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQT-----STDGKEKTTSAKETQ 270
Query: 1526 THRRTSA-----IPRAFTRERPQGRKEAPAPSKAAPAAPPPART-QPSLIADETPPCYSL 1579
+ +TSA + + P+ P+ P P P +P+ + P ++
Sbjct: 271 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 330
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S+ ++ EP P+ + +EPA T P P+P +E SA
Sbjct: 331 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 390
Query: 1640 RRPPVSGLRRRKPRATRLDE----RPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695
+ P +KP T E P E + +E A + + + + A
Sbjct: 391 PKEPAP-TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKP 449
Query: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG 1755
T + A T + + + +T +P A SA K
Sbjct: 450 APTTPKEPAPTTPKEPAPT-------------TTKEPSPTTPKEPAPTTTKSAPTTTKEP 496
Query: 1756 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP 1815
A + T +P +P P P T++ P P PAP K P TP
Sbjct: 497 APTT-TKSAPTTPKEPS-PTTTKEPAPTTPK-----------EPAPTTPKKPAP---TTP 540
Query: 1816 RKVAPPCLAQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
++ AP +PA K P+P T + P TP TP
Sbjct: 541 KEPAPTTPKEPAPTTTKKPAP------------------TTPKEPAPTTPKETAPTTPKK 582
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPAR----TLLAKQHKTQRSPVRI 1930
+ T P ++P T P P P TP T A T + P
Sbjct: 583 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 642
Query: 1931 PFMQRPARRGPPPLARAVPE----PGPRGRAGTE-AGPGARGGRLGLVRVASALSSGSES 1985
+ PA P A P+ P+G A T P + + + ++ +
Sbjct: 643 T-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 701
Query: 1986 SDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEE 2045
S T +P + + + E A + P+G +P + P +E
Sbjct: 702 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT-PKKPAPKE 760
Query: 2046 LRAAPRQGPA------PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
L +GP PA P P+ + PA T + P P E
Sbjct: 761 LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 820
Query: 2100 ASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILR 2159
+ ++ + PD + P SA+ ++ + P+ PG + P +
Sbjct: 821 TTKEPTTIHKSPDESTP--ELSAEPTPKALENSPK------EPGVPTTKTPAATKPEMTT 872
Query: 2160 STLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
+ T +TPE A P+ T + TE+ K ++T+ T P
Sbjct: 873 TAKDKTTERDLRTTPETTTAA--PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 929
Score = 77.8 bits (190), Expect = 1e-13
Identities = 159/775 (20%), Positives = 249/775 (32%), Gaps = 100/775 (12%)
Query: 1468 PLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH 1527
P P PA +P T A TTP E A + ++P P
Sbjct: 363 PAPTTPKEPAPTTTKEPAPTTTKSAP-----TTPKEPAP------TTPKKPAPTTPKEPA 411
Query: 1528 RRTSAIPRAFTRERPQGRKEAPAPS---KAAPAAPP-PARTQPSLIADETPPCYSLSSSA 1583
T P T + P + PAP+ + AP AP PA T P A TP +
Sbjct: 412 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK----EPAP 467
Query: 1584 SSLSEPEPSEP--PAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRR 1641
++ EP P+ P PA P TK+P P + + +P+ + + P+
Sbjct: 468 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 527
Query: 1642 PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLH 1701
P + +KP T P E + +E A + + T
Sbjct: 528 APTTP---KKPAPTT----PKEPAPTTPKEPAPTTTKKPAPT--------------TPKE 566
Query: 1702 QAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKT 1761
A +E + + L+ + L P K E + PE+ T
Sbjct: 567 PAPTTPKETAPTTPKKLT----PTTPEKLAPTTPEKPAPTTPEELAPTTPEE------PT 616
Query: 1762 SGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPP 1821
+P PA P P+ TP PA T P+P +P T TP++ AP
Sbjct: 617 PTTPEEPA-PTTPKAAAPNTPKEPAP----TTPKEPAPTTPKEPAPT-----TPKETAPT 666
Query: 1822 CLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSP 1881
+ AP + P + +PA T ++ P S T TP ++ T
Sbjct: 667 T-PKGTAPTTLKEPAPTTPK---KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 722
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP 1941
P K P T G P P P TP + + T +PA P
Sbjct: 723 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTP 782
Query: 1942 PPLARAVP-EPGP----RGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLT 1996
A P EP P + T P + ++ +S D S
Sbjct: 783 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES------- 835
Query: 1997 FIKESPGLRRRRSE--LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP 2054
+P L + L ++ P +P +P + + +LR P
Sbjct: 836 ----TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 891
Query: 2055 APARQRPPAARPSPG--ERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPD 2112
A + A + E TT++ S + T+K P ++ ++
Sbjct: 892 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTI 951
Query: 2113 GAV-----PAAPASA-DAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATA 2166
P A D A S P+P AP + + +P + + T
Sbjct: 952 TTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTP 1011
Query: 2167 LPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGG 2221
+ + PE P + ++A++QT + N + + L P AGG
Sbjct: 1012 RKMTSTMPELNPTS----RIAEAMLQT----TTRPNQTPNSKLVEVNPKSEDAGG 1058
Score = 74.3 bits (181), Expect = 1e-12
Identities = 124/581 (21%), Positives = 195/581 (33%), Gaps = 65/581 (11%)
Query: 1761 TSGSPRSPAG--PEKPRGTQ----KTTPGVPAVLRGRTVIYVPS-PAPRAQPKGTPGPRA 1813
T +P+ PA P++P T TTP PA ++ P PAP + P
Sbjct: 310 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP---T 366
Query: 1814 TPRKVAPPCLAQPA---APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAK 1870
TP++ AP +PA + +P + + +PA T+ P+ TP
Sbjct: 367 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 426
Query: 1871 TPSSSSSQTSPASQPLPR--KRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV 1928
P++ + +P P K+P T P P P T T+
Sbjct: 427 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT-----------TKEPSP 475
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
P P P P P T++ P A ++ E +
Sbjct: 476 TTPKEPAPTTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530
Query: 1989 SGFRRQLTFIKE-SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELR 2047
+ + T KE +P + + ++ + A + P+ +P + P + +
Sbjct: 531 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 590
Query: 2048 AAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASL----P 2103
AP PA P P+ E P TT E P+ P AA P T K A P
Sbjct: 591 LAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEP 647
Query: 2104 HISVARRPDGAVP--AAPASADAARRSSDGEP------RPLPRVAAPGTTWRRIR---DE 2152
+ + P P AP + ++ EP +P P+ AP TT D+
Sbjct: 648 APTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 707
Query: 2153 DVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS-- 2206
P + T P T +TP++ P G P + T + APK + T+
Sbjct: 708 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 767
Query: 2207 -PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISA------PFVHEGLGVAVGGFPAS 2259
P+ T + P + + P+ K P P E P +
Sbjct: 768 GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 827
Query: 2260 RHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
H SP S P + P+P + + T +AT
Sbjct: 828 IHKSPDES--TPELSAEPTPKALENSPKEPGVPTTKTPAAT 866
Score = 73.9 bits (180), Expect = 2e-12
Identities = 114/517 (22%), Positives = 178/517 (34%), Gaps = 36/517 (6%)
Query: 1799 PAPRAQPKGTPGPR-ATPRKVAPPCLAQPAAPA-KVPSPGQQRSRSLHRPAKTSELATLS 1856
P P+A+ T GP TP++ P +PA+ K P+P +S P + + T S
Sbjct: 290 PTPKAETT-TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT-TPKEPAPTTTKS 347
Query: 1857 QPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTL 1916
P P K P+ ++ + PA P T++A P A PK PA T
Sbjct: 348 APTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT 406
Query: 1917 LAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVA 1976
+ T + PA P EP P A + P
Sbjct: 407 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKE 464
Query: 1977 SALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAV 2036
A ++ E S + T K +P + + ++ +SA + P+ SP + P
Sbjct: 465 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP-TTTKSAPTTPKEPSPTTTKEPAPTT 523
Query: 2037 FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETV 2096
+ + AP PA P P+ ++PA T E P P+
Sbjct: 524 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK-- 581
Query: 2097 KRYASLPHISVARRPDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIR 2150
K + P P+ P AP + + ++ EP P P+ AAP T
Sbjct: 582 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP----- 636
Query: 2151 DEDVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS 2206
E P + P T +TP++ P G P + T + APK + T+
Sbjct: 637 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 696
Query: 2207 ---PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGS 2263
P+ T + P + P+ K P AP +G PA
Sbjct: 697 TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEP--APTTPKGTAPTTLKEPA----- 749
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P+ + P P+ T+ ++ + AP T T
Sbjct: 750 PTTPKKPAPKELAPT-TTKGPTSTTSDKPAPTTPKET 785
Score = 61.2 bits (147), Expect = 1e-08
Identities = 157/750 (20%), Positives = 243/750 (32%), Gaps = 100/750 (13%)
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
VH P+ K P P G + S +R P +++ +
Sbjct: 66 VHNPTSPPSSKKAPPPSGASQTIKSTT----------------KRSPKPPNKKKTKKVIE 109
Query: 1657 LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDS 1716
+E E S +E++ S +S S R I+ NS AA RE +
Sbjct: 110 SEEITEEHSVSENQESSSSSSSSSSSSTI-RKIKSSKNS---------AANRELQKKLKV 159
Query: 1717 ILSFVSGLSVGSTLQPPK-HRKGRQAEGEMGSARRPEKRGAASVKTSGSPR-SPAGPEKP 1774
+ + T +PP G + P+ K S SP+ + A P P
Sbjct: 160 KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 219
Query: 1775 RGT----QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP-------------RK 1817
R + T+ + T + + T G T +
Sbjct: 220 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 279
Query: 1818 VAPPC--LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPA-RLAKTPSS 1874
+AP LA+P A+ + G + P T+ S P+ TP + A T
Sbjct: 280 LAPTSKVLAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 338
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVP---KTPARTLLAKQHKTQRSPVRIP 1931
+ T+ S P K P T P P P K PA T T + P
Sbjct: 339 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 398
Query: 1932 FMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGF 1991
++PA P A P+ P E P + + + + +
Sbjct: 399 -PKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE 456
Query: 1992 RRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPR 2051
T + +P + S + E A + + A PA + +E
Sbjct: 457 PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 516
Query: 2052 QGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA-SLPHISVARR 2110
+ PAP + PA P+ ++PA TT + P+ + PA P T K+ A + P
Sbjct: 517 KEPAPTTPKEPA--PTTPKKPA-PTTPKEPAPTTPKEPA--PTTTKKPAPTTPKEPAPTT 571
Query: 2111 PDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIRDEDVPHILRSTLPA 2164
P P P + + ++ +P P P AP T +E P P
Sbjct: 572 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP-----EEPTPTTPEEPAPT 626
Query: 2165 TALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP----PG 2216
T +TP++ P P P + T + AP T T+P+ +EP P
Sbjct: 627 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT-TLKEPAPTTPK 685
Query: 2217 APAGGQLSLLGSDVDGPSLAKAPIS------APFVHEGLGVAVGGFPASRHGSPSRSARV 2270
PA +L+ P+ K P S AP +G PA +P A
Sbjct: 686 KPAPKELA--------PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT--TPKEPAPT 735
Query: 2271 PPFNYVPSPMVVAATT----DSAAEKAPAT 2296
P P+ + A T + E AP T
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTT 765
Score = 55.8 bits (133), Expect = 5e-07
Identities = 140/666 (21%), Positives = 216/666 (32%), Gaps = 99/666 (14%)
Query: 1325 PAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQ 1384
PAPT P +E P +K A P P P PAP +
Sbjct: 426 PAPTTKEPAPTTPKE----------PAPTAPKKPA----PTTPKEPAPTTPKEPAPTTTK 471
Query: 1385 EDDSCTDSAEGTPVNFSSAASLSDE-----TLQGPPRDQPGGPAGRQRPTGRPTSARQAM 1439
E S T E P SA + + E T P + P + P PT+ ++
Sbjct: 472 EP-SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 528
Query: 1440 GHRHKAGGAGRSAEQSRGAGKNRAGL--ELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
K E + K A + P P PA + T + L
Sbjct: 529 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLT 584
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQG---RKEAP-APSK 1553
TTP + A + E+P P T P T E P + AP P +
Sbjct: 585 PTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 638
Query: 1554 AAPAAPP-PARTQPSLIADETP----PCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTK 1608
AP P PA T P A TP P ++ ++L EP P+ P P+ P TK
Sbjct: 639 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 698
Query: 1609 DP--------------GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
+P G P+P +E P + +KP
Sbjct: 699 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 758
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
L + +G + SD+ + E A T + A T E +
Sbjct: 759 KEL-----APTTTKGPTSTTSDKPAPTTPKE-TAPTTPKEPAPTTPKKPAPTTPETPPPT 812
Query: 1715 DSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
S +S + +T+ H+ ++ E+ + P+ SP+ P P
Sbjct: 813 TSEVSTPTTTKEPTTI----HKSPDESTPELSAEPTPK-------ALENSPKEPGVP-TT 860
Query: 1775 RGTQKTTPGVPAVLRGRTV---IYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAK 1831
+ T P + + +T + A PK T T K + A +
Sbjct: 861 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT--ATTTQ 918
Query: 1832 VPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRP 1891
V S Q + P K + L T + P+ T KT +++ P P+ R
Sbjct: 919 VTSTTTQDT----TPFKITTLKTTTLAPKVTT----TKKTITTTEIMNKPEETAKPKDRA 970
Query: 1892 PVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPP-PLARAVPE 1950
++A +P P+ P T K+ + + P +P +++P P + +PE
Sbjct: 971 TNSKA--------TTPKPQKP--TKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPE 1020
Query: 1951 PGPRGR 1956
P R
Sbjct: 1021 LNPTSR 1026
Score = 54.7 bits (130), Expect = 1e-06
Identities = 121/540 (22%), Positives = 181/540 (33%), Gaps = 61/540 (11%)
Query: 1370 PVPVYMLVPAPAPAQEDDSCT--DSAEGTPVNFSSAA--SLSDETLQGPPRDQPG--GPA 1423
P P PAP +E T ++A TP + L+ T + P P P
Sbjct: 551 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 610
Query: 1424 GRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSK 1483
+ PT PT+ + KA E + K A P P+ P + +
Sbjct: 611 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT-PKEPAPTTPKETAPTT 667
Query: 1484 PGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQ 1543
P T L+ TTP + A P APT T TS T ++P
Sbjct: 668 PKGT-APTTLKEPAPTTPKKPA------------PKELAPTTTKEPTST-----TCDKP- 708
Query: 1544 GRKEAPA-PSKAAPAAPP-PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRG 1601
AP P AP P PA T P A TP ++ ++L EP P+ P P+
Sbjct: 709 ----APTTPKGTAPTTPKEPAPTTPKEPAPTTPK----GTAPTTLKEPAPTTPKKPAPKE 760
Query: 1602 REPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERP 1661
P TK GP P+P +E P + P T +
Sbjct: 761 LAPTTTK--GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 818
Query: 1662 AEGSRERGEEAAGSDRASDLDSVE--WRAIQEGAN--SIVTWLHQAAAATREASSESDSI 1717
++E D ++ S E +A++ + T AA ++ D
Sbjct: 819 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKT 878
Query: 1718 LSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGT 1777
+ +T PK K E + K A + + + + P K T
Sbjct: 879 TERDLRTTPETTTAAPKMTKETATTTEKTT---ESKITATTTQVTSTTTQDTTPFKIT-T 934
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS--- 1834
KTT P V + I + + P RAT K P +P K P+
Sbjct: 935 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 994
Query: 1835 -----PGQQRSRSLHRPAK-TSELATLSQPPRSA----TPPARLAKTPSSSSSQTSPASQ 1884
P ++ ++ P K TS + L+ R A R +TP+S + +P S+
Sbjct: 995 KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1054
>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
Length = 1404
Score = 80.1 bits (196), Expect = 2e-14
Identities = 164/772 (21%), Positives = 260/772 (33%), Gaps = 126/772 (16%)
Query: 1380 PAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG----RPTSA 1435
PAP + T E P A + + +P + PT PT+
Sbjct: 381 PAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTP 440
Query: 1436 RQAMGHRHKAGGAGRSAEQSRGAGKNRAGL-ELPLGRPPSAPADKDGSKPGRTRGDGALQ 1494
++ K E + K A + P P PA KP T
Sbjct: 441 KKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPT------- 493
Query: 1495 SLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR----AFTRERPQGRKE-AP 1549
TP E A P APT T + P+ T+ P KE AP
Sbjct: 494 -----TPKEPA---------PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP 539
Query: 1550 APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKD 1609
+K+AP P + T P ++ + P EP P+ P TK
Sbjct: 540 TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKK 599
Query: 1610 PGPGGGRDSSP-SPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDE----RPAEG 1664
P P ++ +P +P+ + ++ P + P + KP T +E P E
Sbjct: 600 PAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT---PEKPAPTTPEELAPTTPEEP 656
Query: 1665 SRERGEE-AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
+ EE A + +A+ ++ + A T + A T + ++ + G
Sbjct: 657 TPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTP-----KG 711
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPG 1783
+ + +P + A E+ E TS + PA P P+GT TTP
Sbjct: 712 TAPTTLKEPAPTTPKKPAPKELAPTTTKE-------PTSTTCDKPA-PTTPKGTAPTTPK 763
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGT-------PGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
PA + PAP PKGT P P TP+K AP + AP P
Sbjct: 764 EPAPTTPK------EPAP-TTPKGTAPTTLKEPAP-TTPKKPAP----KELAPTTTKGP- 810
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRS---ATPPARLAKTPSSSSSQTSPASQPLPRKRPPV 1893
S + +PA T+ T P+ TP TP + TS S P K P
Sbjct: 811 --TSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868
Query: 1894 TQAA--GALPGPGASPVPKTPARTLLAKQHKTQRSPVRI-PFMQRPAR--------RGPP 1942
+ + P A P PK + T ++P P M A+ R P
Sbjct: 869 IHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTP 928
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKE-- 2000
A P+ TE ++ + + + + + D + F+ +T +K
Sbjct: 929 ETTTAAPKMTKETATTTEKTTESK------ITATTTQVTSTTTQDTTPFK--ITTLKTTT 980
Query: 2001 -SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQ 2059
+P + + +++ E + A P+ RA + P Q
Sbjct: 981 LAPKVTTTKKTITTTEIMNKPEETAKPKD------------------RATNSKATTPKPQ 1022
Query: 2060 RPPAARPSPGERPARRTTSESPSRLP-VRAPAARPETVKRYASLPHISVARR 2110
+P A P + T+++ P +P VR P P K +++P ++ R
Sbjct: 1023 KPTKA-------PKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSR 1067
Score = 78.6 bits (192), Expect = 7e-14
Identities = 153/779 (19%), Positives = 252/779 (32%), Gaps = 93/779 (11%)
Query: 1468 PLGRPPSAPADKDGSKPGR--TRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTP 1525
P+ PS P + D SK + +++ TT ++ D E+ +A T
Sbjct: 257 PINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQT-----STDGKEKTTSAKETQ 311
Query: 1526 THRRTSA-----IPRAFTRERPQGRKEAPAPSKAAPAAPPPART-QPSLIADETPPCYSL 1579
+ +TSA + + P+ P+ P P P +P+ + P ++
Sbjct: 312 SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTI 371
Query: 1580 SSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPR 1639
S+ ++ EP P+ + +EPA T P P+P +E SA
Sbjct: 372 KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTT 431
Query: 1640 RRPPVSGLRRRKPRATRLDE----RPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695
+ P +KP T E P E + +E A + + + + A
Sbjct: 432 PKEPAP-TTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKP 490
Query: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG 1755
T + A T + + + +T +P A SA K
Sbjct: 491 APTTPKEPAPTTPKEPAPT-------------TTKEPSPTTPKEPAPTTTKSAPTTTKEP 537
Query: 1756 AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP 1815
A + T +P +P P P T++ P P PAP K P TP
Sbjct: 538 APTT-TKSAPTTPKEPS-PTTTKEPAPTTPK-----------EPAPTTPKKPAP---TTP 581
Query: 1816 RKVAPPCLAQPA-APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSS 1874
++ AP +PA K P+P T + P TP TP
Sbjct: 582 KEPAPTTPKEPAPTTTKKPAP------------------TTPKEPAPTTPKETAPTTPKK 623
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPAR----TLLAKQHKTQRSPVRI 1930
+ T P ++P T P P P TP T A T + P
Sbjct: 624 LTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPT 683
Query: 1931 PFMQRPARRGPPPLARAVPE----PGPRGRAGTE-AGPGARGGRLGLVRVASALSSGSES 1985
+ PA P A P+ P+G A T P + + + ++ +
Sbjct: 684 T-PKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPT 742
Query: 1986 SDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEE 2045
S T +P + + + E A + P+G +P + P +E
Sbjct: 743 STTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTT-PKKPAPKE 801
Query: 2046 LRAAPRQGPA------PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRY 2099
L +GP PA P P+ + PA T + P P E
Sbjct: 802 LAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT 861
Query: 2100 ASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILR 2159
+ ++ + PD + P SA+ ++ + P+ PG + P +
Sbjct: 862 TTKEPTTIHKSPDESTP--ELSAEPTPKALENSPK------EPGVPTTKTPAATKPEMTT 913
Query: 2160 STLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAP 2218
+ T +TPE A P+ T + TE+ K ++T+ T P
Sbjct: 914 TAKDKTTERDLRTTPETTTAA--PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 970
Score = 77.8 bits (190), Expect = 1e-13
Identities = 159/775 (20%), Positives = 249/775 (32%), Gaps = 100/775 (12%)
Query: 1468 PLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTH 1527
P P PA +P T A TTP E A + ++P P
Sbjct: 404 PAPTTPKEPAPTTTKEPAPTTTKSAP-----TTPKEPAP------TTPKKPAPTTPKEPA 452
Query: 1528 RRTSAIPRAFTRERPQGRKEAPAPS---KAAPAAPP-PARTQPSLIADETPPCYSLSSSA 1583
T P T + P + PAP+ + AP AP PA T P A TP +
Sbjct: 453 PTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPK----EPAP 508
Query: 1584 SSLSEPEPSEP--PAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRR 1641
++ EP P+ P PA P TK+P P + + +P+ + + P+
Sbjct: 509 TTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEP 568
Query: 1642 PPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLH 1701
P + +KP T P E + +E A + + T
Sbjct: 569 APTTP---KKPAPTT----PKEPAPTTPKEPAPTTTKKPAPT--------------TPKE 607
Query: 1702 QAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKT 1761
A +E + + L+ + L P K E + PE+ T
Sbjct: 608 PAPTTPKETAPTTPKKLT----PTTPEKLAPTTPEKPAPTTPEELAPTTPEE------PT 657
Query: 1762 SGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPP 1821
+P PA P P+ TP PA T P+P +P T TP++ AP
Sbjct: 658 PTTPEEPA-PTTPKAAAPNTPKEPAP----TTPKEPAPTTPKEPAPT-----TPKETAPT 707
Query: 1822 CLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSP 1881
+ AP + P + +PA T ++ P S T TP ++ T
Sbjct: 708 T-PKGTAPTTLKEPAPTTPK---KPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPK 763
Query: 1882 ASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP 1941
P K P T G P P P TP + + T +PA P
Sbjct: 764 EPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTP 823
Query: 1942 PPLARAVP-EPGP----RGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLT 1996
A P EP P + T P + ++ +S D S
Sbjct: 824 KETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDES------- 876
Query: 1997 FIKESPGLRRRRSE--LSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGP 2054
+P L + L ++ P +P +P + + +LR P
Sbjct: 877 ----TPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTT 932
Query: 2055 APARQRPPAARPSPG--ERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPD 2112
A + A + E TT++ S + T+K P ++ ++
Sbjct: 933 AAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTI 992
Query: 2113 GAV-----PAAPASA-DAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATA 2166
P A D A S P+P AP + + +P + + T
Sbjct: 993 TTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTTPTP 1052
Query: 2167 LPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGG 2221
+ + PE P + ++A++QT + N + + L P AGG
Sbjct: 1053 RKMTSTMPELNPTS----RIAEAMLQT----TTRPNQTPNSKLVEVNPKSEDAGG 1099
Score = 74.3 bits (181), Expect = 1e-12
Identities = 124/581 (21%), Positives = 195/581 (33%), Gaps = 65/581 (11%)
Query: 1761 TSGSPRSPAG--PEKPRGTQ----KTTPGVPAVLRGRTVIYVPS-PAPRAQPKGTPGPRA 1813
T +P+ PA P++P T TTP PA ++ P PAP + P
Sbjct: 351 TPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP---T 407
Query: 1814 TPRKVAPPCLAQPA---APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAK 1870
TP++ AP +PA + +P + + +PA T+ P+ TP
Sbjct: 408 TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 467
Query: 1871 TPSSSSSQTSPASQPLPR--KRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV 1928
P++ + +P P K+P T P P P T T+
Sbjct: 468 APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTT-----------TKEPSP 516
Query: 1929 RIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDR 1988
P P P P P T++ P A ++ E +
Sbjct: 517 TTPKEPAPTTTKSAPTTTKEPAP-----TTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571
Query: 1989 SGFRRQLTFIKE-SPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELR 2047
+ + T KE +P + + ++ + A + P+ +P + P + +
Sbjct: 572 TPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEK 631
Query: 2048 AAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASL----P 2103
AP PA P P+ E P TT E P+ P AA P T K A P
Sbjct: 632 LAPTTPEKPAPTTPEELAPTTPEEPT-PTTPEEPA--PTTPKAAAPNTPKEPAPTTPKEP 688
Query: 2104 HISVARRPDGAVP--AAPASADAARRSSDGEP------RPLPRVAAPGTTWRRIR---DE 2152
+ + P P AP + ++ EP +P P+ AP TT D+
Sbjct: 689 APTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 748
Query: 2153 DVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS-- 2206
P + T P T +TP++ P G P + T + APK + T+
Sbjct: 749 PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 808
Query: 2207 -PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISA------PFVHEGLGVAVGGFPAS 2259
P+ T + P + + P+ K P P E P +
Sbjct: 809 GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTT 868
Query: 2260 RHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
H SP S P + P+P + + T +AT
Sbjct: 869 IHKSPDES--TPELSAEPTPKALENSPKEPGVPTTKTPAAT 907
Score = 73.9 bits (180), Expect = 2e-12
Identities = 114/517 (22%), Positives = 178/517 (34%), Gaps = 36/517 (6%)
Query: 1799 PAPRAQPKGTPGPR-ATPRKVAPPCLAQPAAPA-KVPSPGQQRSRSLHRPAKTSELATLS 1856
P P+A+ T GP TP++ P +PA+ K P+P +S P + + T S
Sbjct: 331 PTPKAETT-TKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPT-TPKEPAPTTTKS 388
Query: 1857 QPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTL 1916
P P K P+ ++ + PA P T++A P A PK PA T
Sbjct: 389 APTTPKEPAPTTTKEPAPTTPK-EPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTT 447
Query: 1917 LAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVA 1976
+ T + PA P EP P A + P
Sbjct: 448 PKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP--TAPKKPAPTTPKEPAPTTPKE 505
Query: 1977 SALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAV 2036
A ++ E S + T K +P + + ++ +SA + P+ SP + P
Sbjct: 506 PAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAP-TTTKSAPTTPKEPSPTTTKEPAPTT 564
Query: 2037 FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETV 2096
+ + AP PA P P+ ++PA T E P P+
Sbjct: 565 PKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPK-- 622
Query: 2097 KRYASLPHISVARRPDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIR 2150
K + P P+ P AP + + ++ EP P P+ AAP T
Sbjct: 623 KLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTP----- 677
Query: 2151 DEDVPHILRSTLPATALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTS 2206
E P + P T +TP++ P G P + T + APK + T+
Sbjct: 678 KEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTT 737
Query: 2207 ---PSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGS 2263
P+ T + P + P+ K P AP +G PA
Sbjct: 738 TKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEP--APTTPKGTAPTTLKEPA----- 790
Query: 2264 PSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASAT 2300
P+ + P P+ T+ ++ + AP T T
Sbjct: 791 PTTPKKPAPKELAPT-TTKGPTSTTSDKPAPTTPKET 826
Score = 61.2 bits (147), Expect = 1e-08
Identities = 157/750 (20%), Positives = 243/750 (32%), Gaps = 100/750 (13%)
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
VH P+ K P P G + S +R P +++ +
Sbjct: 107 VHNPTSPPSSKKAPPPSGASQTIKSTT----------------KRSPKPPNKKKTKKVIE 150
Query: 1657 LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDS 1716
+E E S +E++ S +S S R I+ NS AA RE +
Sbjct: 151 SEEITEEHSVSENQESSSSSSSSSSSSTI-RKIKSSKNS---------AANRELQKKLKV 200
Query: 1717 ILSFVSGLSVGSTLQPPK-HRKGRQAEGEMGSARRPEKRGAASVKTSGSPR-SPAGPEKP 1774
+ + T +PP G + P+ K S SP+ + A P P
Sbjct: 201 KDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINP 260
Query: 1775 RGT----QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATP-------------RK 1817
R + T+ + T + + T G T +
Sbjct: 261 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKD 320
Query: 1818 VAPPC--LAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPA-RLAKTPSS 1874
+AP LA+P A+ + G + P T+ S P+ TP + A T
Sbjct: 321 LAPTSKVLAKPTPKAETTTKGPALTTP-KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 379
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVP---KTPARTLLAKQHKTQRSPVRIP 1931
+ T+ S P K P T P P P K PA T T + P
Sbjct: 380 EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 439
Query: 1932 FMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGF 1991
++PA P A P+ P E P + + + + +
Sbjct: 440 -PKKPAPTTPKEPAPTTPKE-PTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKE 497
Query: 1992 RRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPR 2051
T + +P + S + E A + + A PA + +E
Sbjct: 498 PAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 557
Query: 2052 QGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA-SLPHISVARR 2110
+ PAP + PA P+ ++PA TT + P+ + PA P T K+ A + P
Sbjct: 558 KEPAPTTPKEPA--PTTPKKPA-PTTPKEPAPTTPKEPA--PTTTKKPAPTTPKEPAPTT 612
Query: 2111 PDGAVPA-----APASADAARRSSDGEPRP-LPRVAAPGTTWRRIRDEDVPHILRSTLPA 2164
P P P + + ++ +P P P AP T +E P P
Sbjct: 613 PKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTP-----EEPTPTTPEEPAPT 667
Query: 2165 TALPLRGSTPED----APAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP----PG 2216
T +TP++ P P P + T + AP T T+P+ +EP P
Sbjct: 668 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPT-TLKEPAPTTPK 726
Query: 2217 APAGGQLSLLGSDVDGPSLAKAPIS------APFVHEGLGVAVGGFPASRHGSPSRSARV 2270
PA +L+ P+ K P S AP +G PA +P A
Sbjct: 727 KPAPKELA--------PTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT--TPKEPAPT 776
Query: 2271 PPFNYVPSPMVVAATT----DSAAEKAPAT 2296
P P+ + A T + E AP T
Sbjct: 777 TPKGTAPTTLKEPAPTTPKKPAPKELAPTT 806
Score = 55.8 bits (133), Expect = 5e-07
Identities = 140/666 (21%), Positives = 216/666 (32%), Gaps = 99/666 (14%)
Query: 1325 PAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQ 1384
PAPT P +E P +K A P P P PAP +
Sbjct: 467 PAPTTKEPAPTTPKE----------PAPTAPKKPA----PTTPKEPAPTTPKEPAPTTTK 512
Query: 1385 EDDSCTDSAEGTPVNFSSAASLSDE-----TLQGPPRDQPGGPAGRQRPTGRPTSARQAM 1439
E S T E P SA + + E T P + P + P PT+ ++
Sbjct: 513 EP-SPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPA--PTTPKEPA 569
Query: 1440 GHRHKAGGAGRSAEQSRGAGKNRAGL--ELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
K E + K A + P P PA + T + L
Sbjct: 570 PTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTP----KKLT 625
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQG---RKEAP-APSK 1553
TTP + A + E+P P T P T E P + AP P +
Sbjct: 626 PTTPEKLAP------TTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE 679
Query: 1554 AAPAAPP-PARTQPSLIADETP----PCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTK 1608
AP P PA T P A TP P ++ ++L EP P+ P P+ P TK
Sbjct: 680 PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 739
Query: 1609 DP--------------GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRA 1654
+P G P+P +E P + +KP
Sbjct: 740 EPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAP 799
Query: 1655 TRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSES 1714
L + +G + SD+ + E A T + A T E +
Sbjct: 800 KEL-----APTTTKGPTSTTSDKPAPTTPKE-TAPTTPKEPAPTTPKKPAPTTPETPPPT 853
Query: 1715 DSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP 1774
S +S + +T+ H+ ++ E+ + P+ SP+ P P
Sbjct: 854 TSEVSTPTTTKEPTTI----HKSPDESTPELSAEPTPK-------ALENSPKEPGVP-TT 901
Query: 1775 RGTQKTTPGVPAVLRGRTV---IYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAK 1831
+ T P + + +T + A PK T T K + A +
Sbjct: 902 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKIT--ATTTQ 959
Query: 1832 VPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRP 1891
V S Q + P K + L T + P+ T KT +++ P P+ R
Sbjct: 960 VTSTTTQDT----TPFKITTLKTTTLAPKVTT----TKKTITTTEIMNKPEETAKPKDRA 1011
Query: 1892 PVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPP-PLARAVPE 1950
++A +P P+ P T K+ + + P +P +++P P + +PE
Sbjct: 1012 TNSKA--------TTPKPQKP--TKAPKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPE 1061
Query: 1951 PGPRGR 1956
P R
Sbjct: 1062 LNPTSR 1067
Score = 54.7 bits (130), Expect = 1e-06
Identities = 121/540 (22%), Positives = 181/540 (33%), Gaps = 61/540 (11%)
Query: 1370 PVPVYMLVPAPAPAQEDDSCT--DSAEGTPVNFSSAA--SLSDETLQGPPRDQPG--GPA 1423
P P PAP +E T ++A TP + L+ T + P P P
Sbjct: 592 PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPT 651
Query: 1424 GRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSK 1483
+ PT PT+ + KA E + K A P P+ P + +
Sbjct: 652 TPEEPT--PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTT-PKEPAPTTPKETAPTT 708
Query: 1484 PGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQ 1543
P T L+ TTP + A P APT T TS T ++P
Sbjct: 709 PKGT-APTTLKEPAPTTPKKPA------------PKELAPTTTKEPTST-----TCDKP- 749
Query: 1544 GRKEAPA-PSKAAPAAPP-PARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRG 1601
AP P AP P PA T P A TP ++ ++L EP P+ P P+
Sbjct: 750 ----APTTPKGTAPTTPKEPAPTTPKEPAPTTPK----GTAPTTLKEPAPTTPKKPAPKE 801
Query: 1602 REPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERP 1661
P TK GP P+P +E P + P T +
Sbjct: 802 LAPTTTK--GPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVST 859
Query: 1662 AEGSRERGEEAAGSDRASDLDSVE--WRAIQEGAN--SIVTWLHQAAAATREASSESDSI 1717
++E D ++ S E +A++ + T AA ++ D
Sbjct: 860 PTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKT 919
Query: 1718 LSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGT 1777
+ +T PK K E + K A + + + + P K T
Sbjct: 920 TERDLRTTPETTTAAPKMTKETATTTEKTT---ESKITATTTQVTSTTTQDTTPFKIT-T 975
Query: 1778 QKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPS--- 1834
KTT P V + I + + P RAT K P +P K P+
Sbjct: 976 LKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTK 1035
Query: 1835 -----PGQQRSRSLHRPAK-TSELATLSQPPRSA----TPPARLAKTPSSSSSQTSPASQ 1884
P ++ ++ P K TS + L+ R A R +TP+S + +P S+
Sbjct: 1036 KPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSE 1095
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 80.1 bits (196), Expect = 2e-14
Identities = 249/1175 (21%), Positives = 405/1175 (34%), Gaps = 214/1175 (18%)
Query: 712 GSCVPSLYVRKQRALEAELDARHLAQALEHLEKQGP-PAAEAATKKPLPPLRHLDGLAQD 770
G V +L K AE A + E++G PA AA K + D ++D
Sbjct: 145 GKTVANLLSGKSPRKSAEPSAN--TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 771 YASDSGCFDDDDAPSS------LAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRR 824
+S S D + S A+A A G P A +P G+A A T+
Sbjct: 203 TSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGA-------TPAPPGKAGAVASQTKA 255
Query: 825 GGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAP 884
G E + ++S E + ++ + A A+ + S S ++ P +E+P
Sbjct: 256 GKPEEDSESSSEESSDSEEETPAAKALLQAK----------ASGKTSQVGAASAPAKESP 305
Query: 885 REGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLP 944
R+G A + GP + +AG R ++ S S + + + G P+
Sbjct: 306 RKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 945 CP--------LAALASRREDPRCGQPRPSRLDLDLPGCQAEPPA-REATSA--DARVRTI 993
P A R+ P Q + + + D E + REA +A A+V+ +
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 994 KLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQAWLPADHLSKVPEKLAAAPLSVAS 1052
SP ++ AS G PL G G P + P+ + K E ++ +
Sbjct: 424 GKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 1053 KALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSEGG----------DLDDSDSSLEG 1099
+ ++ P SL SS + P + G +D+S+SS E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 537
Query: 1100 LEEAGPSEA-------------ELDSTWRAPGATS---------LPVAIPAPRR------ 1131
+ A EA ++ T P T+ + V APR+
Sbjct: 538 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 597
Query: 1132 --------NRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSE 1183
G ED++ S S++ ++T L ++ S+G A+S+P +
Sbjct: 598 PAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT-VGQAKSVGKGLQVK-AASVPVK 655
Query: 1184 PCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDI 1243
GQG+ + P + + Q + + + + EA Q ++ VK+
Sbjct: 656 GSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 714
Query: 1244 ADCRERCRLPSELDAGSVRFTVEKPDENFSCAS-----SLSALALHEHYVQQDVELRLLP 1298
A+ P+ A S + T+ P + + A+ S S + Q L P
Sbjct: 715 AN-------PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 767
Query: 1299 SACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPA-RLRK 1357
++ P G A + + GP +D E E E L P+ + +
Sbjct: 768 ASVPSVGKAVATAA-------QAQTGPEEDSGSSEEESDSEEE--AETLAQVKPSGKTHQ 818
Query: 1358 VASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDSCTDSAEGTPVNFSSAASLSDETL 1411
+ +AL P + A P P P+ A A ++DDS + S E + AA S + +
Sbjct: 819 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVI 878
Query: 1412 QGP-----PRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAE--------QSRGA 1458
+ P P P GPA ++ R+A A + +E Q
Sbjct: 879 KPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 938
Query: 1459 GKNRAGLELPLGRPPSAP----ADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS 1514
G + +P P AP A SK DG Q
Sbjct: 939 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ-------------------- 978
Query: 1515 DEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADE-- 1572
E PA + + + + +A + Q KA+ A PP ARTQPS D
Sbjct: 979 --EGPATQVSKKNPASLPLTQAALKVLAQ---------KASEAQPPVARTQPSSGVDSAV 1027
Query: 1573 -----TPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEE 1627
T P S S A ++ + P V + P + D DSS S +EE
Sbjct: 1028 GTLPATSP-QSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD-----SEDSSDSSSGSEE 1081
Query: 1628 LLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWR 1687
P+ L P +R + E + E E+ + S L
Sbjct: 1082 ------DGEGPQGAKSAHTL---GPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTP 1132
Query: 1688 AIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ-AEGEMG 1746
+ ANS QA+ AT + S SV STL G+Q A+ +
Sbjct: 1133 GLTP-ANS------QASKATPKLDSSP----------SVSSTLAAKDDPDGKQEAKPQQA 1175
Query: 1747 SARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTT 1781
+ K G + +P+ P+K G + +
Sbjct: 1176 AGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1210
Score = 78.2 bits (191), Expect = 9e-14
Identities = 149/626 (23%), Positives = 229/626 (36%), Gaps = 68/626 (10%)
Query: 1702 QAAAATREASSESDSILSFVSG----LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAA 1757
QA +++ + SS SD V L V + P K G+ A + P K GA
Sbjct: 195 QADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGA-----TPAPPGKAGAV 249
Query: 1758 SVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPRA 1813
+ +T +G P S + E+ +++ TP A+L+ + + P K +P A
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 1814 TPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPS 1873
P APP PA ++ S+S + + E A P P R A P+
Sbjct: 310 AP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 366
Query: 1874 SSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV-R 1929
S + A P PRK P Q +S R LA + Q P+ +
Sbjct: 367 KESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 425
Query: 1930 IPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRS 1989
P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD S
Sbjct: 426 SPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDSS 479
Query: 1990 GFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSRC 2043
+P + + A+ +S +G + G A+ P SS
Sbjct: 480 DGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEE 536
Query: 2044 EELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA 2100
A + PA A+ +P P P + T+ S PVR P
Sbjct: 537 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA---- 592
Query: 2101 SLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDV 2154
A P G+ PA PA ++ SD E G + + V
Sbjct: 593 -----GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKSV 641
Query: 2155 PHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP 2214
L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 642 GKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEEA 697
Query: 2215 PGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPF 2273
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 698 AASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PPV 754
Query: 2274 NYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 755 RNPQNSTVLARGPASVPSVGKAVATA 780
Score = 70.5 bits (171), Expect = 2e-11
Identities = 210/1015 (20%), Positives = 335/1015 (33%), Gaps = 175/1015 (17%)
Query: 935 GYCPREHMLPCPLAALASRRED----PRCGQP-RPSRLDLDLPGCQAEPPAREATSADAR 989
G PR+ P L S E+ P G +P + +E + + D
Sbjct: 154 GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVE 213
Query: 990 VRTI-KLSPTYQHVPLLEGASRAGAEPLAGPGISPGARKQ--AWLP-------ADHLSKV 1039
V+ K+ +G GA P A PG + Q A P ++ S
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKGATP-APPGKAGAVASQTKAGKPEEDSESSSEESSDS 272
Query: 1040 PEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSA--GRPGPS-----EGGDLDD 1092
E+ AA + +KA K + + ++ S + A G+ GP+ G +D
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 332
Query: 1093 SDSSLEGLEEAGPSEAELDSTWRAPG--ATSLPV-------AIPAPRRNRGRGLGV---- 1139
S SS E + + A+ + +AP A S P A PAP R G
Sbjct: 333 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 392
Query: 1140 --EDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSE 1197
E+ + SSS E+ L + V LG +SP + +P S G G +
Sbjct: 393 KQEEDSRSSSEESDSDREALAAMNAAQVKPLG--KSPQV------KPASTMGMGPLGKGA 444
Query: 1198 LPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELD 1257
P PG K P P+ Q +WE D S+
Sbjct: 445 GPVPPG--------KVGPATPSAQVG--------KWEE---------DSESSSEESSDSS 479
Query: 1258 AGSVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAG 1317
G V V E SL + L+ P++ P +G +
Sbjct: 480 DGEVPTAVAPAQEK-----SLGNI------------LQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 1318 HRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLV 1377
+ + + +AD E A A + +A P + +
Sbjct: 523 KAEKPMDNSESSEESSDSADSE------------------EAPAAMTAAQAKPA---LKI 561
Query: 1378 PAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQ 1437
P + + T SA+ PV + A T P P G QRP +S+ +
Sbjct: 562 PQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 621
Query: 1438 AMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
+ K G A + Q++ GK GL++ P + G+ P G +
Sbjct: 622 SDSEEEKTGLA-VTVGQAKSVGK---GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTH-RRTSAIPRAFTRERPQGRKEAPAPSKAAP 1556
E++ +DS+E + A T ++T A P + AP K
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737
Query: 1557 AAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGP---- 1612
AA + PS + PP + + S++ P+ P+V + A GP
Sbjct: 738 AAAQAKQRSPSKV---KPPVRNPQN--STVLARGPASVPSV-GKAVATAAQAQTGPEEDS 791
Query: 1613 GGGRDSSPSPRAAEELLQ-------RCISSAL-PRRRPPVSGLRRRKPRATRLDERPAEG 1664
G + S S AE L Q I +AL P + P G P T P+
Sbjct: 792 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT----GPSAA 847
Query: 1665 SRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGL 1724
+ +++ S SD D +A AA A ++
Sbjct: 848 QAGKQDDSGSSSEESDSDG------------------EAPAAVTSAQVIKPPLI------ 883
Query: 1725 SVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP-RGTQKTTPG 1783
+ P + G A A ++ AS T+ S S + E TQ TPG
Sbjct: 884 ----FVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 939
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSL 1843
+ V+ +P+ PR PK + ++ ++ + + P+ +
Sbjct: 940 IRT-----NVVTMPTAHPRIAPKASMAGASSSKESS---RISDGKKQEGPATQVSKKNPA 991
Query: 1844 HRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAG 1898
P + L L+Q A PP +A+T SS ++ + P + QA G
Sbjct: 992 SLPLTQAALKVLAQKASEAQPP--VARTQPSSGVDSAVGTLPATSPQSTSVQAKG 1044
Score = 62.4 bits (150), Expect = 5e-09
Identities = 162/806 (20%), Positives = 281/806 (34%), Gaps = 97/806 (12%)
Query: 1445 AGGAGRSAEQSRGAGKN-----RAGLELPLGRPPSAPADKD---GSKPGRTRGDGALQSL 1496
AG A S+E + + +A ++ R SAPA G+ P GA+ S
Sbjct: 193 AGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 252
Query: 1497 CLTTPTEEAVYCFY--GNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKA 1554
EE +DS+EE PAA A+ +A + A AP+K
Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAA---------KALLQAKASGKTSQVGAASAPAKE 303
Query: 1555 AP---AAP-PPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP 1610
+P AAP PP +T P++ + S S+S S+ E P P G+ P V
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV---- 359
Query: 1611 GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGE 1670
RAA + P + P G PR T PA + G+
Sbjct: 360 ------------RAA----------SAPAKESPRKGAAPAPPRKTG----PAAAQVQVGK 393
Query: 1671 EAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTL 1730
+ S R+S +S R N+ + + AS+ L +G +
Sbjct: 394 QEEDS-RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV 452
Query: 1731 QP--PKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVL 1788
P P + G+ E S+ V T+ +P EK G +L
Sbjct: 453 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ----EKSLGN---------IL 499
Query: 1789 RGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAK 1848
+ + P+ +P P GP A K P ++ S + + + A+
Sbjct: 500 QAK-----PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554
Query: 1849 TSELATLSQPPRSATPPARLAKTPSSSSSQTSPA--SQPLPRKRPPVTQAAGALPG-PGA 1905
L P A P KT +++S++ +P PRK T AG+ P G
Sbjct: 555 AKP--ALKIPQTKACPK----KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 608
Query: 1906 SPVPKTPARTLLAKQHKTQRSPVRIPFMQ-RPARRGPPPLARAVPEPGPRGRAGTEAGPG 1964
+ P + + + +++ + + Q + +G A +VP G G+ PG
Sbjct: 609 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 1965 ARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGA 2024
G + V+ S S + + + +++ +++ + A + A + +G
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 2025 SPRRGRPALPAVFLCSSRCEELRAAPRQGP--APARQRPPAARPSPGERPARRTTSESPS 2082
G+ + A R P + P + R PA+ PS G+ A +++
Sbjct: 729 ISAPGK-VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787
Query: 2083 RLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEP--RPLPRVA 2140
+ ++ + +L + + + A + ++ R+ + P + P A
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 2141 APG-------TTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQT 2193
G ++ D + P + S PL P +PAGP T
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSA-QVIKPPLIFVDPNRSPAGPAATPAQAQAAST 906
Query: 2194 EEVAAPKTNSSTSPSLETREPPGAPA 2219
A +++ S S E+ + PA
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPA 932
Score = 60.8 bits (146), Expect = 1e-08
Identities = 215/1020 (21%), Positives = 336/1020 (32%), Gaps = 228/1020 (22%)
Query: 1300 ACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVA 1359
A P G AG + E+ + + S +++E + L A + +V
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 1360 SALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGP 1414
+A P + A P P PA A AQ DS S++ SD + P
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS--------QSSSEESDSEEEAP 347
Query: 1415 PRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GRSAEQSRGAGKN--- 1461
+ +P G A + R P G K G A G+ E SR + +
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDS 407
Query: 1462 --------RAGLELPLGRPPSA-PADKDGSKP-GRTRGDGALQSLCLTTPTEEAVYCFYG 1511
A PLG+ P PA G P G+ G + TP+ +
Sbjct: 408 DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 467
Query: 1512 NDSDEE----------PPAAAPT------------PTHRRTSAIPRA-------FTRERP 1542
++S E P A AP PT P+ E+P
Sbjct: 468 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 527
Query: 1543 QGRKEAP------APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSL--------SE 1588
E+ A S+ APAA A+ +P+L +T C +++ +S ++
Sbjct: 528 MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQ 587
Query: 1589 PEPSEPPAVHPRGREPAV---TKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVS 1645
A P G PAV T+ P DSS S + E + ++ + + +
Sbjct: 588 APRKAGTATSPAGSSPAVAGGTQRPA----EDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 1646 GLRRRKPRATRLDERPAEGSRERGEEAA------------GSDRASDLDSVEWRAIQEGA 1693
GL+ + P +GS +G +++ D +S E + E A
Sbjct: 644 GLQVKAASV------PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697
Query: 1694 NS----IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSAR 1749
+ + T + + A A++ + S +S + G + K R R
Sbjct: 698 AASPAQVKTSVKKTQAKANPAAARAPSAKGTIS--APGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 1750 RPEK-----RGAASVKTSG-----SPRSPAGPEKPRGT---------------QKTTPGV 1784
P+ RG ASV + G + ++ GPE+ G+ Q G
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 815
Query: 1785 PAVLRGRTVIYVPSPAPRAQPK--GTPGPRA---------------------------TP 1815
+R SP A P G GP A +
Sbjct: 816 THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 875
Query: 1816 RKVAPPCL-----AQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATP---PAR 1867
+ + PP + PA PA P+ Q ++ S R A+ SE S S PA
Sbjct: 876 QVIKPPLIFVDPNRSPAGPAATPA--QAQAASTPRKARASESTARSSSSESEDEDVIPAT 933
Query: 1868 LAKTPSSSSSQ-TSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRS 1926
TP ++ T P + P + P AGA +S + + A Q ++++
Sbjct: 934 QCLTPGIRTNVVTMPTAHP---RIAPKASMAGASSSKESSRISDGKKQEGPATQ-VSKKN 989
Query: 1927 PVRIPFMQ-------RPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASAL 1979
P +P Q + A PP+AR P G GT + S
Sbjct: 990 PASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT-------------LPATSPQ 1036
Query: 1980 SSGSESSDRSGFRR-------QLTFIKESPGLRRRRSELSS-AESAASAPQGASPRRGRP 2031
S+ ++ + R+ Q T ES S+ SS +E PQGA +
Sbjct: 1037 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGA--KSAHT 1094
Query: 2032 ALPAVFLCSSRCEELRAAPRQGPAPA-RQRPPAARPSPGERPARRTTSESPSRLPVRAPA 2090
P + EE A + A Q + +PG PA S++ +L
Sbjct: 1095 LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD----- 1149
Query: 2091 ARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIR 2150
+ P A+ PDG A P A P+ + AA GTT ++ R
Sbjct: 1150 SSPSVSSTLAAKDD------PDGKQEAKPQQAAGML-----SPKTGGKEAASGTTPQKSR 1198
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 79.3 bits (194), Expect = 4e-14
Identities = 245/1175 (20%), Positives = 403/1175 (34%), Gaps = 213/1175 (18%)
Query: 712 GSCVPSLYVRKQRALEAELDARHLAQALEHLEKQGP-PAAEAATKKPLPPLRHLDGLAQD 770
G V +L K AE A + E++G PA AA K + D ++D
Sbjct: 145 GKTVANLLSGKSPRKSAEPSAN--TTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSED 202
Query: 771 YASDSGCFDDDDAPSS------LAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRR 824
+S S D + S A+A A G P A +P G+A A T+
Sbjct: 203 TSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGA-------TPAPPGKAGAVASQTKA 255
Query: 825 GGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAP 884
G E + ++S E + ++ + A A+ + S S ++ P +E+P
Sbjct: 256 GKPEEDSESSSEESSDSEEETPAAKALLQAK----------ASGKTSQVGAASAPAKESP 305
Query: 885 REGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLP 944
R+G A + GP + +AG R ++ S S + + + G P+
Sbjct: 306 RKGAAPAPPGKTGPAVAKAQAGKREED--SQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 945 CP--------LAALASRREDPRCGQPRPSRLDLDLPGCQAEPPA-REATSA--DARVRTI 993
P A R+ P Q + + + D E + REA +A A+V+ +
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 994 KLSPTYQHVPLLEGASRAGAEPLA-GPGISPGARKQAWLPADHLSKVPEKLAAAPLSVAS 1052
SP ++ AS G PL G G P + P+ + K E ++ +
Sbjct: 424 GKSPQ------VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 1053 KALQKLAAQEGPL---SLSRCSSLSSLSSAGRPGPSEGG----------DLDDSDSSLEG 1099
+ ++ P SL SS + P + G +D+S+SS E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEES 537
Query: 1100 LEEAGPSEA-------------ELDSTWRAPGATS---------LPVAIPAPRR------ 1131
+ A EA ++ T P T+ + V APR+
Sbjct: 538 SDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS 597
Query: 1132 --------NRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSE 1183
G ED++ S S++ ++T L ++ S+G A+S+P +
Sbjct: 598 PAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT-VGQAKSVGKGLQVK-AASVPVK 655
Query: 1184 PCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDI 1243
GQG+ + P + + Q + + + + EA Q ++ VK+
Sbjct: 656 GSLGQGTAPVLPGKTGPTVTQ-VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAK 714
Query: 1244 ADCRERCRLPSELDAGSVRFTVEKPDENFSCAS-----SLSALALHEHYVQQDVELRLLP 1298
A+ P+ A S + T+ P + + A+ S S + Q L P
Sbjct: 715 AN-------PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGP 767
Query: 1299 SACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPA-RLRK 1357
++ P G A + + GP +D E E E L P+ + +
Sbjct: 768 ASVPSVGKAVATAA-------QAQTGPEEDSGSSEEESDSEEE--AETLAQVKPSGKTHQ 818
Query: 1358 VASALVPGRR-----ALPVPVYMLVPAPAPA-QEDDSCTDSAEGTPVNFSSAASLSDETL 1411
+ +AL P + A P P P+ A A ++DDS + S E + AA S + +
Sbjct: 819 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVI 878
Query: 1412 QGP-----PRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAE--------QSRGA 1458
+ P P P GPA ++ R+A A + +E Q
Sbjct: 879 KPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTP 938
Query: 1459 GKNRAGLELPLGRPPSAP----ADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDS 1514
G + +P P AP A SK DG Q
Sbjct: 939 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ-------------------- 978
Query: 1515 DEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADE-- 1572
E PA + + + + +A + Q KA+ A PP ARTQPS D
Sbjct: 979 --EGPATQVSKKNPASLPLTQAALKVLAQ---------KASEAQPPVARTQPSSGVDSAV 1027
Query: 1573 -----TPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEE 1627
T P S S A ++ + P V + P + D DSS S +EE
Sbjct: 1028 GTLPATSP-QSTSVQAKGTNKLRKPKLPEVQQATKAPESSDD-----SEDSSDSSSGSEE 1081
Query: 1628 LLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWR 1687
G + K T + P+ + EE A D+ + +
Sbjct: 1082 ---------------DGEGPQGAKSAHTLVGPTPSR-TETLVEETAAESSEDDVVAPS-Q 1124
Query: 1688 AIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQ-AEGEMG 1746
++ G + T S S + S SV STL G+Q A+ +
Sbjct: 1125 SLLSG--------YMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQA 1176
Query: 1747 SARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTT 1781
+ K G + +P+ P+K G + +
Sbjct: 1177 AGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1211
Score = 78.2 bits (191), Expect = 9e-14
Identities = 149/626 (23%), Positives = 229/626 (36%), Gaps = 68/626 (10%)
Query: 1702 QAAAATREASSESDSILSFVSG----LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAA 1757
QA +++ + SS SD V L V + P K G+ A + P K GA
Sbjct: 195 QADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGA-----TPAPPGKAGAV 249
Query: 1758 SVKT-SGSPR--SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQP-KGTPGPRA 1813
+ +T +G P S + E+ +++ TP A+L+ + + P K +P A
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 1814 TPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPS 1873
P APP PA ++ S+S + + E A P P R A P+
Sbjct: 310 AP---APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 366
Query: 1874 SSSSQTSPASQPLPRKRPPV---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPV-R 1929
S + A P PRK P Q +S R LA + Q P+ +
Sbjct: 367 KESPRKGAAPAP-PRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 425
Query: 1930 IPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRS 1989
P ++ + G PL + P P G+ G A P A+ G+ + SS ESSD S
Sbjct: 426 SPQVKPASTMGMGPLGKGA-GPVPPGKVG-PATPSAQVGKW----EEDSESSSEESSDSS 479
Query: 1990 GFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPAL------PAVFLCSSRC 2043
+P + + A+ +S +G + G A+ P SS
Sbjct: 480 DGEVPTAV---APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEE 536
Query: 2044 EELRAAPRQGPA---PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYA 2100
A + PA A+ +P P P + T+ S PVR P
Sbjct: 537 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA---- 592
Query: 2101 SLPHISVARRPDGAVPAA------PASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDV 2154
A P G+ PA PA ++ SD E G + + V
Sbjct: 593 -----GTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVG------QAKSV 641
Query: 2155 PHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREP 2214
L+ + A ++P++GS + A P KT V Q + + SS S ++ E
Sbjct: 642 GKGLQ--VKAASVPVKGSLGQ-GTAPVLPGKTGPTVTQVKAEKQEDSESSEEES-DSEEA 697
Query: 2215 PGAPAGGQLSLLGSDVD-GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPF 2273
+PA + S+ + P+ A+AP SA G V ++ SPS+ PP
Sbjct: 698 AASPAQVKTSVKKTQAKANPAAARAP-SAKGTISAPGKVVTAAAQAKQRSPSKVK--PPV 754
Query: 2274 NYVPSPMVVAATTDSAAEKAPATASA 2299
+ V+A S A A+A
Sbjct: 755 RNPQNSTVLARGPASVPSVGKAVATA 780
Score = 70.5 bits (171), Expect = 2e-11
Identities = 210/1015 (20%), Positives = 335/1015 (33%), Gaps = 175/1015 (17%)
Query: 935 GYCPREHMLPCPLAALASRRED----PRCGQP-RPSRLDLDLPGCQAEPPAREATSADAR 989
G PR+ P L S E+ P G +P + +E + + D
Sbjct: 154 GKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVE 213
Query: 990 VRTI-KLSPTYQHVPLLEGASRAGAEPLAGPGISPGARKQ--AWLP-------ADHLSKV 1039
V+ K+ +G GA P A PG + Q A P ++ S
Sbjct: 214 VKASEKILQVRAASAPAKGTPGKGATP-APPGKAGAVASQTKAGKPEEDSESSSEESSDS 272
Query: 1040 PEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSA--GRPGPS-----EGGDLDD 1092
E+ AA + +KA K + + ++ S + A G+ GP+ G +D
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 332
Query: 1093 SDSSLEGLEEAGPSEAELDSTWRAPG--ATSLPV-------AIPAPRRNRGRGLGV---- 1139
S SS E + + A+ + +AP A S P A PAP R G
Sbjct: 333 SQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVG 392
Query: 1140 --EDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSE 1197
E+ + SSS E+ L + V LG +SP + +P S G G +
Sbjct: 393 KQEEDSRSSSEESDSDREALAAMNAAQVKPLG--KSPQV------KPASTMGMGPLGKGA 444
Query: 1198 LPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELD 1257
P PG K P P+ Q +WE D S+
Sbjct: 445 GPVPPG--------KVGPATPSAQVG--------KWEE---------DSESSSEESSDSS 479
Query: 1258 AGSVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAG 1317
G V V E SL + L+ P++ P +G +
Sbjct: 480 DGEVPTAVAPAQEK-----SLGNI------------LQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 1318 HRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLV 1377
+ + + +AD E A A + +A P + +
Sbjct: 523 KAEKPMDNSESSEESSDSADSE------------------EAPAAMTAAQAKPA---LKI 561
Query: 1378 PAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQ 1437
P + + T SA+ PV + A T P P G QRP +S+ +
Sbjct: 562 PQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEE 621
Query: 1438 AMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLC 1497
+ K G A + Q++ GK GL++ P + G+ P G +
Sbjct: 622 SDSEEEKTGLA-VTVGQAKSVGK---GLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQV 677
Query: 1498 LTTPTEEAVYCFYGNDSDEEPPAAAPTPTH-RRTSAIPRAFTRERPQGRKEAPAPSKAAP 1556
E++ +DS+E + A T ++T A P + AP K
Sbjct: 678 KAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVT 737
Query: 1557 AAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGP---- 1612
AA + PS + PP + + S++ P+ P+V + A GP
Sbjct: 738 AAAQAKQRSPSKV---KPPVRNPQN--STVLARGPASVPSV-GKAVATAAQAQTGPEEDS 791
Query: 1613 GGGRDSSPSPRAAEELLQ-------RCISSAL-PRRRPPVSGLRRRKPRATRLDERPAEG 1664
G + S S AE L Q I +AL P + P G P T P+
Sbjct: 792 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKT----GPSAA 847
Query: 1665 SRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGL 1724
+ +++ S SD D +A AA A ++
Sbjct: 848 QAGKQDDSGSSSEESDSDG------------------EAPAAVTSAQVIKPPLI------ 883
Query: 1725 SVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKP-RGTQKTTPG 1783
+ P + G A A ++ AS T+ S S + E TQ TPG
Sbjct: 884 ----FVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPG 939
Query: 1784 VPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSL 1843
+ V+ +P+ PR PK + ++ ++ + + P+ +
Sbjct: 940 IRT-----NVVTMPTAHPRIAPKASMAGASSSKESS---RISDGKKQEGPATQVSKKNPA 991
Query: 1844 HRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAG 1898
P + L L+Q A PP +A+T SS ++ + P + QA G
Sbjct: 992 SLPLTQAALKVLAQKASEAQPP--VARTQPSSGVDSAVGTLPATSPQSTSVQAKG 1044
Score = 63.5 bits (153), Expect = 2e-09
Identities = 215/1018 (21%), Positives = 335/1018 (32%), Gaps = 223/1018 (21%)
Query: 1300 ACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVA 1359
A P G AG + E+ + + S +++E + L A + +V
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEED--SESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 1360 SALVPGRR-----ALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGP 1414
+A P + A P P PA A AQ DS S++ SD + P
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDS--------QSSSEESDSEEEAP 347
Query: 1415 PRDQPGGPAGRQRPTGRPTSARQAMGHR----HKAGGA------GRSAEQSRGAGKN--- 1461
+ +P G A + R P G K G A G+ E SR + +
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDS 407
Query: 1462 --------RAGLELPLGRPPSA-PADKDGSKP-GRTRGDGALQSLCLTTPTEEAVYCFYG 1511
A PLG+ P PA G P G+ G + TP+ +
Sbjct: 408 DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEED 467
Query: 1512 NDSDEE----------PPAAAPT------------PTHRRTSAIPRA-------FTRERP 1542
++S E P A AP PT P+ E+P
Sbjct: 468 SESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKP 527
Query: 1543 QGRKEAP------APSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSL--------SE 1588
E+ A S+ APAA A+ +P+L +T C +++ +S ++
Sbjct: 528 MDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQ 587
Query: 1589 PEPSEPPAVHPRGREPAV---TKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVS 1645
A P G PAV T+ P DSS S + E + ++ + + +
Sbjct: 588 APRKAGTATSPAGSSPAVAGGTQRPA----EDSSSSEESDSEEEKTGLAVTVGQAKSVGK 643
Query: 1646 GLRRRKPRATRLDERPAEGSRERGEEAA------------GSDRASDLDSVEWRAIQEGA 1693
GL+ + P +GS +G +++ D +S E + E A
Sbjct: 644 GLQVKAASV------PVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEA 697
Query: 1694 NS----IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSAR 1749
+ + T + + A A++ + S +S + G + K R R
Sbjct: 698 AASPAQVKTSVKKTQAKANPAAARAPSAKGTIS--APGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 1750 RPEK-----RGAASVKTSG-----SPRSPAGPEKPRGT---------------QKTTPGV 1784
P+ RG ASV + G + ++ GPE+ G+ Q G
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK 815
Query: 1785 PAVLRGRTVIYVPSPAPRAQPK--GTPGPRA---------------------------TP 1815
+R SP A P G GP A +
Sbjct: 816 THQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 875
Query: 1816 RKVAPPCL-----AQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATP---PAR 1867
+ + PP + PA PA P+ Q ++ S R A+ SE S S PA
Sbjct: 876 QVIKPPLIFVDPNRSPAGPAATPA--QAQAASTPRKARASESTARSSSSESEDEDVIPAT 933
Query: 1868 LAKTPSSSSSQ-TSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRS 1926
TP ++ T P + P + P AGA +S + + A Q ++++
Sbjct: 934 QCLTPGIRTNVVTMPTAHP---RIAPKASMAGASSSKESSRISDGKKQEGPATQ-VSKKN 989
Query: 1927 PVRIPFMQ-------RPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASAL 1979
P +P Q + A PP+AR P G GT + S
Sbjct: 990 PASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGT-------------LPATSPQ 1036
Query: 1980 SSGSESSDRSGFRR-------QLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPA 2032
S+ ++ + R+ Q T ES SE SS S+ S G P+ + A
Sbjct: 1037 STSVQAKGTNKLRKPKLPEVQQATKAPESSD----DSEDSSDSSSGSEEDGEGPQGAKSA 1092
Query: 2033 LPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAAR 2092
V SR E L + A PS T +P+ +A A
Sbjct: 1093 HTLVGPTPSRTETL----VEETAAESSEDDVVAPSQSLLSGYMTPGLTPAN--SQASKAT 1146
Query: 2093 PETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIR 2150
P+ + ++ PDG A P A P+ + AA GTT ++ R
Sbjct: 1147 PKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGML-----SPKTGGKEAASGTTPQKSR 1199
Score = 62.4 bits (150), Expect = 5e-09
Identities = 162/806 (20%), Positives = 281/806 (34%), Gaps = 97/806 (12%)
Query: 1445 AGGAGRSAEQSRGAGKN-----RAGLELPLGRPPSAPADKD---GSKPGRTRGDGALQSL 1496
AG A S+E + + +A ++ R SAPA G+ P GA+ S
Sbjct: 193 AGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQ 252
Query: 1497 CLTTPTEEAVYCFY--GNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKA 1554
EE +DS+EE PAA A+ +A + A AP+K
Sbjct: 253 TKAGKPEEDSESSSEESSDSEEETPAA---------KALLQAKASGKTSQVGAASAPAKE 303
Query: 1555 AP---AAP-PPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDP 1610
+P AAP PP +T P++ + S S+S S+ E P P G+ P V
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQV---- 359
Query: 1611 GPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGE 1670
RAA + P + P G PR T PA + G+
Sbjct: 360 ------------RAA----------SAPAKESPRKGAAPAPPRKTG----PAAAQVQVGK 393
Query: 1671 EAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTL 1730
+ S R+S +S R N+ + + AS+ L +G +
Sbjct: 394 QEEDS-RSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV 452
Query: 1731 QP--PKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVL 1788
P P + G+ E S+ V T+ +P EK G +L
Sbjct: 453 GPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ----EKSLGN---------IL 499
Query: 1789 RGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAK 1848
+ + P+ +P P GP A K P ++ S + + + A+
Sbjct: 500 QAK-----PTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 554
Query: 1849 TSELATLSQPPRSATPPARLAKTPSSSSSQTSPA--SQPLPRKRPPVTQAAGALPG-PGA 1905
L P A P KT +++S++ +P PRK T AG+ P G
Sbjct: 555 AKP--ALKIPQTKACPK----KTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 608
Query: 1906 SPVPKTPARTLLAKQHKTQRSPVRIPFMQ-RPARRGPPPLARAVPEPGPRGRAGTEAGPG 1964
+ P + + + +++ + + Q + +G A +VP G G+ PG
Sbjct: 609 TQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG 668
Query: 1965 ARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGA 2024
G + V+ S S + + + +++ +++ + A + A + +G
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT 728
Query: 2025 SPRRGRPALPAVFLCSSRCEELRAAPRQGP--APARQRPPAARPSPGERPARRTTSESPS 2082
G+ + A R P + P + R PA+ PS G+ A +++
Sbjct: 729 ISAPGK-VVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGP 787
Query: 2083 RLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEP--RPLPRVA 2140
+ ++ + +L + + + A + ++ R+ + P + P A
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 2141 APG-------TTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQT 2193
G ++ D + P + S PL P +PAGP T
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSA-QVIKPPLIFVDPNRSPAGPAATPAQAQAAST 906
Query: 2194 EEVAAPKTNSSTSPSLETREPPGAPA 2219
A +++ S S E+ + PA
Sbjct: 907 PRKARASESTARSSSSESEDEDVIPA 932
>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
Length = 1489
Score = 76.6 bits (187), Expect = 3e-13
Identities = 191/796 (23%), Positives = 262/796 (32%), Gaps = 115/796 (14%)
Query: 1549 PAPSKAAPAAPPP-----ARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGRE 1603
PA + AP A P A + PS++ + S+SS E S P + P +
Sbjct: 528 PASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWD 587
Query: 1604 PAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAE 1663
P P P + S P+ E + A PR P S + L E
Sbjct: 588 PLDPGVPAPQAPQAPSEVPQLVSETWASPLFPA-PRPFPAQSSASG----SFLLSGWDPE 642
Query: 1664 GSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSG 1723
G R GE AG D A L G W+ + +S DS S
Sbjct: 643 G-RGAGETLAG-DPAEVL----------GERGTAPWVEEEEEEEEGSSPGEDS-----SS 685
Query: 1724 LSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPR--SPAGPEKP------R 1775
L G + + P EG P +RG A G P P PE R
Sbjct: 686 LGGGPSRRGPLPCPLCSREGACSCL--PLERGDAVAGWGGHPALGCPHPPEDDSSLRAER 743
Query: 1776 GTQKTTPGVPAV---------LRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQP 1826
G+ P P L G P P P P P PR A P A P
Sbjct: 744 GSLADLPMAPPASAPPEFLDPLMGAAAPQYPGRGP---PPAPPPPPPPPRAPADPA-ASP 799
Query: 1827 AAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPL 1886
P+ V SPG S +P + + TP + P +++ +P
Sbjct: 800 DPPSAVASPGSGLSSPGPKPGDSGY--------ETETPFSPEGAFPGGGAAEEEGVPRPR 851
Query: 1887 PRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLAR 1946
PP A P PG P+P + Q T++ + + + R
Sbjct: 852 APPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQ--LLMSLREDVTRNLLGEKGA 909
Query: 1947 AVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFI----KESP 2002
E GPR +AG GPG R GL R + L +G ++ S +T + + +P
Sbjct: 910 TARETGPR-KAG--RGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVLENGDQRAP 966
Query: 2003 GLRRRRSE---LSSAESAASAPQGAS---PRRGRPALPAVFLCSSRCEELRAAPRQGPAP 2056
G+ + +E L S E + PRR AL L S E + G P
Sbjct: 967 GIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGE-KVLVNGGLTP 1025
Query: 2057 ARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVP 2116
+ + P R T P P RAP +T + + P I P+ ++
Sbjct: 1026 PKSEDKVSENGGLRFP--RNTERPPETGPWRAPGPWEKTPESWGPAPTIG-EPAPETSLE 1082
Query: 2117 AAPASADAARRSSDGEPRPLPRVAA-------PGTTWRRIRDEDVPHIL----------- 2158
APA + + GE P P A PGT R P
Sbjct: 1083 RAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGG 1142
Query: 2159 RSTLPATALPLRG-STPEDAPAG-----------PPPRKTSDAVVQTEEVAAPKTNSSTS 2206
R+ + P G + DA AG PP +A + E A P+ +
Sbjct: 1143 RAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRARPEVA 1202
Query: 2207 PSLETREPPGAP---AGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGS 2263
P E PGAP AGG +L G D D P + P + LG G +
Sbjct: 1203 PEGE----PGAPDSRAGGDTALSG-DGDPPKPERKGPEMPRLFLDLGPPQGNSEQIKARL 1257
Query: 2264 PSRSARVPPFNYVPSP 2279
S +PP P P
Sbjct: 1258 SRLSLALPPLTLTPFP 1273
Score = 56.6 bits (135), Expect = 3e-07
Identities = 179/782 (22%), Positives = 251/782 (32%), Gaps = 161/782 (20%)
Query: 1378 PAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQ 1437
P P PAQ S + G A ETL G P + G R T+
Sbjct: 621 PRPFPAQSSASGSFLLSGWDPEGRGAG----ETLAGDPAEVLGE---------RGTAPWV 667
Query: 1438 AMGHRHKAGGAGRSAEQSRGAGKNRAG-LELPLGRPPSAPADKDGSKPGRTRGDGALQSL 1496
+ G + S G G +R G L PL A + + G G +L
Sbjct: 668 EEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPLERGDAVAGWGGHPAL 727
Query: 1497 CLTTPTEE--AVYCFYGNDSD--EEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPS 1552
P E+ ++ G+ +D PPA+AP + A + P GR PAP
Sbjct: 728 GCPHPPEDDSSLRAERGSLADLPMAPPASAPPEF---LDPLMGAAAPQYP-GRGPPPAP- 782
Query: 1553 KAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVH-------------- 1598
P PPP R A PP +++S S LS P P + +
Sbjct: 783 ---PPPPPPPRAPADPAASPDPPS-AVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPG 838
Query: 1599 ---------PRGREPAVTKDPG-----PGGGRDSSPSPRAAEE-LLQRCISSALPRRRPP 1643
PR R P DPG P G P PR ++Q L R
Sbjct: 839 GGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLRED 898
Query: 1644 VSGLRRRKPRATRLDERPAEGSRERG--EEAAGSDRASDL--DSVEWRAIQEGANSIVTW 1699
V+ + AT + P + R G E+ G +R + + + ++ N +
Sbjct: 899 VTRNLLGEKGATARETGPRKAGRGPGNREKVPGLNRDPTVLGNGKQAPSLSLPVNGVTVL 958
Query: 1700 LH--QAAAATREASSESDSILSFVSGLSV--GSTLQPPKHRKGRQAEGEMGSARRPEK-- 1753
+ Q A E ++E+ ++ S V L PP+ + GE+ S EK
Sbjct: 959 ENGDQRAPGIEEKAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVL 1018
Query: 1754 --------RGAASVKTSGSPRSPAGPEKPRGT---------QKT---------------- 1780
+ V +G R P E+P T +KT
Sbjct: 1019 VNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPE 1078
Query: 1781 -----TPGVPAVLRGRTV-IYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPA---- 1830
P AV+ R P P A GT P R AP P AP
Sbjct: 1079 TSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPGTERR--APETGGAPRAPGAGRL 1136
Query: 1831 ------KVP-----SPGQQRSRSLHRPAKTSELATLSQPPRSATPPA-----RLAKTPSS 1874
+ P +PG + A + PP PP RL P
Sbjct: 1137 DLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPR 1196
Query: 1875 SSSQTSPASQPLPRKRPPVTQAAG--ALPGPGASPVP--KTPARTLL-----AKQHKTQR 1925
+ + +P +P P ++A G AL G G P P K P L Q +++
Sbjct: 1197 ARPEVAPEGEP----GAPDSRAGGDTALSGDGDPPKPERKGPEMPRLFLDLGPPQGNSEQ 1252
Query: 1926 SPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSES 1985
R+ R + PP P PGPR A GA GG G E
Sbjct: 1253 IKARL---SRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGED 1309
Query: 1986 SDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEE 2045
D E ++A AA+ P+G P R R A V + S+ +
Sbjct: 1310 EDED----------------EEEDEEAAAPGAAAGPRG--PGRARAAPVPVVVSSADADA 1351
Query: 2046 LR 2047
R
Sbjct: 1352 AR 1353
Score = 42.0 bits (97), Expect = 0.007
Identities = 119/543 (21%), Positives = 165/543 (30%), Gaps = 80/543 (14%)
Query: 1717 ILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRG--AASVKTSGSPRSP-AGPEK 1773
+L G L + +G E ARR RG A + + + +P +P A P
Sbjct: 482 LLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSN 541
Query: 1774 PRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAP-----PCLAQPAA 1828
P +TP V V+ R+ R + G+P P P P P A
Sbjct: 542 PFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAPQA 601
Query: 1829 PAKVPSPGQQRSRS----LHRPAKTSELATLSQPPRSATPPARLA-KTPSSSSSQTSPAS 1883
P++VP + S RP A+ S P R A +T + ++
Sbjct: 602 PSEVPQLVSETWASPLFPAPRPFPAQSSASGSFLLSGWDPEGRGAGETLAGDPAEVLGER 661
Query: 1884 QPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPP 1943
P + G+ PG +S + P+R R P+ P R P
Sbjct: 662 GTAPWVEEEEEEEEGSSPGEDSSSLGGGPSR----------RGPLPCPLCSREGACSCLP 711
Query: 1944 LARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPG 2003
L R G G AL D S R + + + P
Sbjct: 712 LERGDAVAGWGGHP--------------------ALGCPHPPEDDSSLRAERGSLADLPM 751
Query: 2004 LRRRRS--ELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRP 2061
+ E A+APQ P RG P P P P P
Sbjct: 752 APPASAPPEFLDPLMGAAAPQ--YPGRGPPPAP---------------PPPPPPPRAPAD 794
Query: 2062 PAARPSPGERPARRTTS-ESPSRLPVRAPAARPETVKRYASLPHISVARR---PDGAVPA 2117
PAA P P A + SP P + + P A P P
Sbjct: 795 PAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPP 854
Query: 2118 APASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGST---- 2173
P A R D P PLP T ++ E + LR + L +G+T
Sbjct: 855 EPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARET 914
Query: 2174 -PEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDG 2232
P A GP R+ + + V N +PSL P G L D
Sbjct: 915 GPRKAGRGPGNREKVPGLNRDPTVLG---NGKQAPSL------SLPVNGVTVLENGDQRA 965
Query: 2233 PSL 2235
P +
Sbjct: 966 PGI 968
Score = 35.4 bits (80), Expect = 0.65
Identities = 61/249 (24%), Positives = 86/249 (34%), Gaps = 35/249 (14%)
Query: 1366 RRALPVPVYMLVPAPAPAQED---DSCTDSAEGTPVNFSSAASLSDETLQGPPRDQ---- 1418
R +L +P L P P P + A G + A ++E + D+
Sbjct: 1259 RLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEEDE 1318
Query: 1419 ----PGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPS 1474
PG AG P G P AR A + +A RG K+ G + P
Sbjct: 1319 EAAAPGAAAG---PRG-PGRARAAPVPVVVSSADADAARPLRGLLKSPRGAD----EPED 1370
Query: 1475 APADKDGSKPGRTRGDGALQSLCLTTPTEE-AVYCFYGNDSDEEPPAAAPTPTHRRTSAI 1533
+ ++ K GD + TPT E +V D+D P A PTP H A
Sbjct: 1371 SELERK-RKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTDPSTPPAPPTPPH---PAT 1426
Query: 1534 PRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEP-EPS 1592
P G + ++ P PPP P C+S S + +L P P+
Sbjct: 1427 PGDGFPSNDSGFGGSFEWAEDFPLLPPPG----------PPLCFSRFSVSPALETPGPPA 1476
Query: 1593 EPPAVHPRG 1601
P P G
Sbjct: 1477 RAPDARPAG 1485
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 76.3 bits (186), Expect = 3e-13
Identities = 193/853 (22%), Positives = 270/853 (31%), Gaps = 181/853 (21%)
Query: 1314 HFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVP---------ARLRKVASALVP 1364
H GHR P G RP GA CL A P + ++ S++ P
Sbjct: 323 HPPGHRLVPAAPPGPGPRPPGAESHG------CLPATRPPGSDLRESRVQRSRMDSSVSP 376
Query: 1365 GRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAG 1424
VP P P GT + SS++S S+ L+G PG P
Sbjct: 377 AATTACVPYAPSRPPGLP------------GTTTSSSSSSS-SNTGLRGV-EPNPGIPGA 422
Query: 1425 RQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLG-------------R 1471
T A + H A S + GA L LP G R
Sbjct: 423 DHYQT----PALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLR 478
Query: 1472 PPSAPADKDGSKPGRTRGDGA-LQSLCLTT-----------PTEEAVYC-----FYGNDS 1514
PP PA G R DG L+ L T P E F
Sbjct: 479 PPPPPAWLKGPACRAAREDGEILEELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQ 538
Query: 1515 DEEPPAAAPTPT----------HRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPP--PA 1562
D P PTPT H + A P +F R P P +PA P P
Sbjct: 539 DSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPP 598
Query: 1563 RTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSP 1622
+L PP +++ S PE P P+ E PGP
Sbjct: 599 LVPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPKTPEVGPGPPPGP---------- 648
Query: 1623 RAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLD 1682
S P+ PP G+ R RL + P ++ EE A
Sbjct: 649 -----------LSKAPQPVPP--GVGELPARGPRLFDFPPTPLEDQFEEPA--------- 686
Query: 1683 SVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAE 1742
E++ + +G +I+ L ++ E G QPP +
Sbjct: 687 --EFKILPDGLANIMKMLDESIRKEEEQQQH-----------EAGVAPQPPLKEPFASLQ 733
Query: 1743 GEMGSARRPEKRG---AASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSP 1799
+ P A + T+ + + A E+ + P P + + + P
Sbjct: 734 SPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAK-----FPPPS 788
Query: 1800 APRAQPKGTPGPRATPRKVAPPCLAQP-------AAPAKVPSPGQQRSRSLHRPAKTSEL 1852
P+ P P P + + +A Q AA + P P S P+ + L
Sbjct: 789 QPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATAL 848
Query: 1853 ATLSQPPRSATPPARLAKTPS-SSSSQTSPASQPLPRKRPPVTQAAGALPGPG------- 1904
PP SA P A+ + PS SSSSQ S + P R+R AG P PG
Sbjct: 849 -----PPTSAAPSAQGSPQPSASSSSQFSTSGGPWARER-----RAGEEPVPGPMTPTQP 898
Query: 1905 ASPVPKTPARTLLAKQHKTQRS-PVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTE--A 1961
P+ PAR+ + R+ + + R A P+ A P +GTE
Sbjct: 899 PPPLSLPPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEP-----ADSGTERLL 953
Query: 1962 GPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAP 2021
P G V S + + RR K+S G R R E A A
Sbjct: 954 PPAQAKEEAGGVAAVSGSCKRRQKEHQKEHRRHRRACKDSVGRRPR-------EGRAKAK 1006
Query: 2022 QGASPRRGRPALPAVFLCSSRCE-----------ELRAAPRQGPAPARQRPPAARPSP-- 2068
+ R L + L S + +A P PAP P+A+P+P
Sbjct: 1007 AKVPKEKSRRVLGNLDLQSEEIQGREKSRPDLGGASKAKPPTAPAPPSAPAPSAQPTPPS 1066
Query: 2069 GERPARRTTSESP 2081
P ++ E+P
Sbjct: 1067 ASVPGKKAREEAP 1079
Score = 73.2 bits (178), Expect = 3e-12
Identities = 170/766 (22%), Positives = 243/766 (31%), Gaps = 183/766 (23%)
Query: 1549 PAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSE------------PEPSEPPA 1596
P P +PP T+P L + + S+ E P P+
Sbjct: 262 PPPLPGLATSPPFQLTKPGLWSTLHGDAWGPERKGSAPPERQEQRHSLPHPYPYPAPAYT 321
Query: 1597 VHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATR 1656
HP G PGPG P P AE LP RPP S LR + + +R
Sbjct: 322 AHPPGHRLVPAAPPGPG------PRPPGAES------HGCLPATRPPGSDLRESRVQRSR 369
Query: 1657 LDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDS 1716
+D + + A S R L T +SS S S
Sbjct: 370 MDSSVSPAATTACVPYAPS-RPPGL-----------------------PGTTTSSSSSSS 405
Query: 1717 ILSFVSGLSVGSTLQPPKHRKGRQAE----GEMG----SARRPEKRGAASVKTSGSPRSP 1768
+ + G+ + H + E G +G S+R+P A+ P P
Sbjct: 406 SNTGLRGVEPNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGP 465
Query: 1769 AGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPK----------GTPGPRATPRKV 1818
+ P P + P P ++ PA RA + GT GP PR
Sbjct: 466 SSPPPPPCPRLLRPPPPPA-------WLKGPACRAAREDGEILEELFFGTEGP---PRPA 515
Query: 1819 APPC------LAQPAA-----------PAKVPSPGQQRSRSLHRPAKTSELATLSQPPRS 1861
PP L PA+ P P+P S S +S +S P
Sbjct: 516 PPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFP--- 572
Query: 1862 ATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQH 1921
PP LA++ SPA P + PP+ ALP P P + +
Sbjct: 573 --PPPYLARSIDPLPRPPSPAQNP---QDPPLVPLTLALP-----PAPPSSCHQNTSGSF 622
Query: 1922 KTQRSP-VRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPG-----ARGGRL----- 1970
+ SP R+ F + P PP PGP +A PG ARG RL
Sbjct: 623 RRPESPRPRVSFPKTPEVGPGPP-------PGPLSKAPQPVPPGVGELPARGPRLFDFPP 675
Query: 1971 ------------------GLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELS 2012
GL + L + ++ + P L+ + L
Sbjct: 676 TPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQ--QQHEAGVAPQPPLKEPFASLQ 733
Query: 2013 SAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQG---PAPARQRPPAARPSPG 2069
S +AP +P ++ +E P P P + PP ++P P
Sbjct: 734 SPFPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPP 793
Query: 2070 ERPARRTTSESPSRLPV--------RAPAARPETVKRYASLPHISVARRPDGAVPAAPAS 2121
P S S V R A T R LP + P A P +
Sbjct: 794 PPPPPSPASLLKSLASVLEGQKYCYRGTGAAVST--RPGPLPTTQYSPGPPSGATALPPT 851
Query: 2122 ADAARRSSDGEPRP----LPRVAAPGTTW---RRIRDEDVPHILRSTLPATALPLRGSTP 2174
+A S+ G P+P + + G W RR +E VP + T P L L
Sbjct: 852 --SAAPSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSL----- 904
Query: 2175 EDAPAGPPPRKTSDAVVQ----TEEVAAPKTNSSTSPS--LETREP 2214
PP R S+ + + E + S+T P+ ++T EP
Sbjct: 905 ------PPARSESEVLEEISRACETLVERVGRSATDPADPVDTAEP 944
Score = 46.2 bits (108), Expect = 4e-04
Identities = 114/484 (23%), Positives = 152/484 (31%), Gaps = 84/484 (17%)
Query: 1816 RKVAPPCLAQPAAPAKVPSPGQQRSRS---LHRPAKTSELATLSQPPRSATPPARLAKTP 1872
++ A P + QP PA + P + S R SE L PP PP L P
Sbjct: 198 KRAAEPPVVQPVPPAALSGPSGEEGLSPGGKRRRGCNSEQTGL--PPGLPLPPPPLPPPP 255
Query: 1873 SSSSSQTSP-----ASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSP 1927
P S P +P + L G P K A +Q + P
Sbjct: 256 PPPPPPPPPLPGLATSPPFQLTKPGLWST---LHGDAWGPERKGSAPPERQEQRHSLPHP 312
Query: 1928 VRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSD 1987
P PA PP R VP P GPG R G+ES
Sbjct: 313 YPYP---APAYTAHPPGHRLVPAAPP--------GPGPR-------------PPGAESHG 348
Query: 1988 RSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELR 2047
R ++R R + S + +A +A +P R P LP SS
Sbjct: 349 CLPATRPPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRP-PGLPGTTTSSSSSSSSN 407
Query: 2048 AAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISV 2107
R P+PG P + PA R H S
Sbjct: 408 TGLR-----------GVEPNPG----------IPGADHYQTPALEVSHHGRLGPSAHSS- 445
Query: 2108 ARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAP--------GTTWRRIRDEDVPHILR 2159
R+P PAA S P P PR+ P G R R++ IL
Sbjct: 446 -RKPFLGAPAATPHLSLPPGPSSPPPPPCPRLLRPPPPPAWLKGPACRAAREDG--EILE 502
Query: 2160 STLPATALPLRGSTP----EDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPP 2215
T P R + P + GPP + S + P T +++S + +
Sbjct: 503 ELFFGTEGPPRPAPPPLPHREGFLGPPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHS 562
Query: 2216 GAPAG----GQLSLLGSDVD----GPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRS 2267
+PAG L +D PS A+ P P V L + P+S H + S S
Sbjct: 563 SSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAP-PSSCHQNTSGS 621
Query: 2268 ARVP 2271
R P
Sbjct: 622 FRRP 625
Score = 45.4 bits (106), Expect = 6e-04
Identities = 208/952 (21%), Positives = 282/952 (29%), Gaps = 215/952 (22%)
Query: 1322 EEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPA 1381
EEG +P G R RG ++ + L PG P P + P P
Sbjct: 220 EEGLSPGGKRRRGCNSEQ--------------------TGLPPGLPLPPPP--LPPPPPP 257
Query: 1382 PAQEDDSCTDSAEGTPVNFSSAASLSDETLQGP---PRDQPGGPAGRQR-------PTGR 1431
P A P + S TL G P + P RQ P
Sbjct: 258 PPPPPPPLPGLATSPPFQLTKPGLWS--TLHGDAWGPERKGSAPPERQEQRHSLPHPYPY 315
Query: 1432 PTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDG 1491
P A A H+ A R G G LP RPP + D S+ R+R D
Sbjct: 316 PAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGC-LPATRPPGS--DLRESRVQRSRMDS 372
Query: 1492 ALQ----SLCL------------TTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR 1535
++ + C+ TT + + EP P H +T A+
Sbjct: 373 SVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVEPNPGIPGADHYQTPALEV 432
Query: 1536 AFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPP 1595
+ + P APAA P P + PPC L L P P
Sbjct: 433 SHHGRLGPSAHSSRKPFLGAPAATPHLSLPPGPSSPPPPPCPRL------LRPPPP---- 482
Query: 1596 AVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRK---- 1651
PA K P R+ E+L+ RP L R+
Sbjct: 483 --------PAWLKGPACRAAREDG-------EILEELFFGTEGPPRPAPPPLPHREGFLG 527
Query: 1652 PRATRLD---------ERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQ 1702
P A+R P + +GS +S V + A SI
Sbjct: 528 PPASRFSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPVSFPPPPYLARSI----DP 583
Query: 1703 AAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEK---RGAASV 1759
A + D L V TL P + GS RRPE R +
Sbjct: 584 LPRPPSPAQNPQDPPL-------VPLTLALPPAPPSSCHQNTSGSFRRPESPRPRVSFPK 636
Query: 1760 KTSGSPRSPAGPEKPRGTQKTTPGVPAV-LRG-RTVIYVPSPAPR-----AQPKGTPGPR 1812
P P GP + Q PGV + RG R + P+P A+ K P
Sbjct: 637 TPEVGPGPPPGPLS-KAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGL 695
Query: 1813 ATPRK------------------VAP-PCLAQPAAPAKVPSPGQQRSRS------LHRPA 1847
A K VAP P L +P A + P P + +
Sbjct: 696 ANIMKMLDESIRKEEEQQQHEAGVAPQPPLKEPFASLQSPFPTDTAPTTTAPAVAVTTTT 755
Query: 1848 KTSELATLSQ-----PPRSATPPARLAKTPSSSSSQTSPASQPLPRK------------- 1889
T+ T +Q PP + PP LAK P S Q P P P
Sbjct: 756 TTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQK 815
Query: 1890 ------RPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPP 1943
V+ G LP SP P + A L P P+ +G P
Sbjct: 816 YCYRGTGAAVSTRPGPLPTTQYSPGPPSGATAL-------------PPTSAAPSAQGSPQ 862
Query: 1944 LARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALS------------SGSESSDRSGF 1991
P + T GP AR R G V ++ + SES
Sbjct: 863 -----PSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEI 917
Query: 1992 RRQLTFIKESPGLRRRRSELSSAESAASAPQGAS----PRRGRPALPAVFLCSSRCEELR 2047
R + E G R ++A A G P + + V S C+ +
Sbjct: 918 SRACETLVERVG-RSATDPADPVDTAEPADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQ 976
Query: 2048 AAPRQGPAPARQRPPAARPSPGERPAR-------RTTSESPSRLPVRAPAARPETVKRYA 2100
++ R+ A + S G RP + E R+ E R
Sbjct: 977 ---KEHQKEHRRHRRACKDSVGRRPREGRAKAKAKVPKEKSRRVLGNLDLQSEEIQGREK 1033
Query: 2101 SLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDE 2152
S P + A + AP SA A +P P P + PG ++ R+E
Sbjct: 1034 SRPDLGGASKAKPPTAPAPPSAPA----PSAQPTP-PSASVPG---KKAREE 1077
Score = 42.4 bits (98), Expect = 0.005
Identities = 108/512 (21%), Positives = 147/512 (28%), Gaps = 103/512 (20%)
Query: 1753 KRGAASVKTSGSPR-----SPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKG 1807
KRG VK + P PA P G + +PG RG ++ G
Sbjct: 191 KRGGPPVKRAAEPPVVQPVPPAALSGPSGEEGLSPGGKR-RRGCN----------SEQTG 239
Query: 1808 TPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPAR 1867
P P PP P P P P + P + ++ S A P R
Sbjct: 240 LP-----PGLPLPPPPLPPPPPPPPPPPPPLPGLATSPPFQLTKPGLWSTLHGDAWGPER 294
Query: 1868 LAKTPSSSSSQTS-----------------------PASQPLPRKRPPVTQAAGALPG-- 1902
P Q PA+ P P RPP ++ G LP
Sbjct: 295 KGSAPPERQEQRHSLPHPYPYPAPAYTAHPPGHRLVPAAPPGPGPRPPGAESHGCLPATR 354
Query: 1903 -PGASPVPKTPARTLLAKQHKTQRSPVRIPFM-QRPARRGPPPLARAVPEPGPRGRAGTE 1960
PG+ R+ + + +P+ RP + + G G E
Sbjct: 355 PPGSDLRESRVQRSRMDSSVSPAATTACVPYAPSRPPGLPGTTTSSSSSSSSNTGLRGVE 414
Query: 1961 AGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASA 2020
PG G G R+ G LS +S
Sbjct: 415 PNPGIPGADHYQTPALEVSHHGRLGPSAHSSRKPFL------GAPAATPHLSLPPGPSSP 468
Query: 2021 PQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAP-----ARQRPPAARPSPGERPARR 2075
P PR RP P +L C RAA G + PP RP+P P R
Sbjct: 469 PPPPCPRLLRPPPPPAWLKGPAC---RAAREDGEILEELFFGTEGPP--RPAPPPLPHRE 523
Query: 2076 TTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRP 2135
+ PA+R SV + P P ++ S+ G
Sbjct: 524 GF--------LGPPASR------------FSVGTQDSHTPPTPPTPTTSSSNSNSGSHSS 563
Query: 2136 LPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGP-----PPRKTSDAV 2190
P A P + P++ RS P P P+D P P PP S
Sbjct: 564 SP--AGP------VSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCH 615
Query: 2191 VQTE------EVAAPKTNSSTSPSLETREPPG 2216
T E P+ + +P + PPG
Sbjct: 616 QNTSGSFRRPESPRPRVSFPKTPEVGPGPPPG 647
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 75.5 bits (184), Expect = 6e-13
Identities = 209/842 (24%), Positives = 282/842 (33%), Gaps = 149/842 (17%)
Query: 1372 PVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRP--- 1428
P L P P DS S G + SS+ L + GPP P P R +
Sbjct: 678 PSSHLPPTPRATTRQDS---SLGGRARHMSSSQELLGD---GPPG--PSSPMSRSQEYLL 729
Query: 1429 ---TGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGR----PPSAPADKDG 1481
T R+A RH G + + A GK R LP G PP P
Sbjct: 730 DEGPAPGTPPREARPGRH--GHSIKRASVPPVPGKPRQ--VLPPGTSHFTPPQTPTKTRP 785
Query: 1482 SKPGRTRGD-GALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAP-TPTHRRTSAIPRAFTR 1539
P G G + PT + + PP P +P S R F
Sbjct: 786 GSPQALGGPHGPAPATAKVKPTPQLL-----------PPTERPMSPRSLPQSPTHRGFAY 834
Query: 1540 ERPQGRKEAPAPSKAAPAAPPPARTQPSLI----ADETPP-----CYSLSSSASSLSEPE 1590
PQ + P+ PA PP P+L AD P +SL+ A+S SEPE
Sbjct: 835 VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPE 894
Query: 1591 PSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSAL-PRRR----PPVS 1645
E + P P T G S +P A++ + R S A+ PR++ PP
Sbjct: 895 RDE--LLVPAAAGPYATVQRRVGRSH-SVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPK 951
Query: 1646 GLRRRKPRATRLDERPAEGSRERG--EEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQA 1703
A DE + E G A RASDL ++ G+ V ++
Sbjct: 952 RSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAG----SVDTGSAGSV----KS 1003
Query: 1704 AAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSG 1763
AA E SS + G + P H R A PE A+V S
Sbjct: 1004 IAAMLELSS--------IGGGGRAARRPPEGHPTPRPAS--------PEPGRVATVLASV 1047
Query: 1764 SPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCL 1823
+ GP G V R RT + P A + PG A P
Sbjct: 1048 KHKEAIGP-----------GGEVVNRRRT-LSGPVTGLLATARRGPGESADP-------- 1087
Query: 1824 AQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARL-AKTPSSSSSQTSPA 1882
P G+QR R + E L++ SAT R+ AK + +
Sbjct: 1088 ----GPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILT 1143
Query: 1883 SQPLPRKRPPVTQA-AGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGP 1941
++RP + AG P P S V T+ + Q P +P PA P
Sbjct: 1144 ESDTVKRRPKAKEREAGPEPPPPLS-VYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPP 1202
Query: 1942 PPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKES 2001
LA P P P G A A P + V S + +S + S
Sbjct: 1203 TDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPG-----PGS 1257
Query: 2002 PGLRRRRSELSSAESAASAPQGASPR-RGRPALPAVFLCSSRCEELRAAPRQGPAPARQR 2060
P ++R A P SP+ P P + A P P+PARQ
Sbjct: 1258 PEVKR----------AHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQP 1307
Query: 2061 PPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPA 2120
P A PG P + SP++ P +P A P VPA P
Sbjct: 1308 PAALAKPPGTPP---SLGASPAKPP--SPGA-------------------PALHVPAKPP 1343
Query: 2121 SADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLR---GSTPEDA 2177
A AA ++ P P A+PG + R+ + E+ L + L A +R P D+
Sbjct: 1344 RAAAAAAAAAAAPPAPPEGASPGDSARQ-KLEETSACLAAALQAVEEKIRQEDAQGPRDS 1402
Query: 2178 PA 2179
A
Sbjct: 1403 AA 1404
Score = 60.5 bits (145), Expect = 2e-08
Identities = 181/824 (21%), Positives = 268/824 (32%), Gaps = 166/824 (20%)
Query: 1539 RERPQGRK----EAPAPSKAAPA---APPPARTQPSLIADETPPCYSLSSSASSLSEPEP 1591
R+ PQ + E+P P + PA +P Q S ++DE L ++ + +E P
Sbjct: 620 RKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDE------LQAAMTGPAEVGP 673
Query: 1592 S-EPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRR 1650
+ E P+ H A T+ GGR S +++ELL P P+S
Sbjct: 674 TTEKPSSHLPPTPRATTRQDSSLGGRARHMS--SSQELL----GDGPPGPSSPMS----- 722
Query: 1651 KPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREA 1710
+ + LDE PA G+ R E R + G + + R+
Sbjct: 723 RSQEYLLDEGPAPGTPPR----------------EARPGRHGHSIKRASVPPVPGKPRQV 766
Query: 1711 SSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAG 1770
L G++ P + G + P A+ K +P+
Sbjct: 767 -------------LPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPP 813
Query: 1771 PEKPRGTQKTTPGVPAVLRGRTVIYV-PSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAP 1829
E+P + +P R YV P P PGP P A P L P
Sbjct: 814 TERPMSPRS----LPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEA 869
Query: 1830 AKVPSPGQQRSRSLHRPAKTSELATLSQ--PPRSATPPARLAKTPSSSSSQTSPA----- 1882
P ++R+ SL+R A + + P +A P A + + S S +PA
Sbjct: 870 DAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKN 929
Query: 1883 ---SQPL---PRKR----PPVTQAAGALPGPGAS--PVPKT-PARTLLAKQHKTQRSPVR 1929
SQ PRK+ PP +++ AL + PVP P LL + + +R+
Sbjct: 930 VNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDL 989
Query: 1930 I---------------PFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVR 1974
++ + G AR PE P R + PG L V+
Sbjct: 990 AGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPE-PGRVATVLASVK 1048
Query: 1975 VASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALP 2034
A+ G E + RR LS + A P G A P
Sbjct: 1049 HKEAIGPGGE-------------------VVNRRRTLSGPVTGLLATARRGP--GESADP 1087
Query: 2035 AVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPE 2094
F+ + P +G A + PP A+ RR ++ + V+ +
Sbjct: 1088 GPFVEDGTGRQRPRGPSKGEAGV-EGPPLAKVEASATLKRRIRAKQNQQENVKFILTESD 1146
Query: 2095 TVKRYASL----------PHISVARRPDGAVPAAPASADAARRSSDGEPRP--------- 2135
TVKR P +SV G V PAS A P P
Sbjct: 1147 TVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLA 1206
Query: 2136 ----LP-------RVAAPGTTWRRIRDEDVPHILRSTLPATA-LPLRG----------ST 2173
LP + A P + + + + VP + S P + +PL G T
Sbjct: 1207 HLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGT 1266
Query: 2174 PEDAPAGPPPRKTSDAVVQT-------EEVAAPKTNSSTSPSLETREPPGAPAGGQLSLL 2226
P PPP T+ V+ +P + + P +PPG P S
Sbjct: 1267 PPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPA 1326
Query: 2227 GSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHG-SPSRSAR 2269
G P P A PA G SP SAR
Sbjct: 1327 KPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSAR 1370
Score = 38.5 bits (88), Expect = 0.077
Identities = 44/161 (27%), Positives = 58/161 (36%), Gaps = 22/161 (13%)
Query: 1349 AAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSD 1408
A P + V + VP + P P VP P P + A GTP S
Sbjct: 1222 AKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPE---VKRAHGTPPPVSPKPP-PP 1277
Query: 1409 ETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRS--AEQSRGAGKNRAGLE 1466
T P + G P+G P+ P+ ARQ K G S A ++ L
Sbjct: 1278 PTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALH 1337
Query: 1467 LPLGRPPSA-----------PADKDGSKPGRTRGDGALQSL 1496
+P +PP A PA +G+ P GD A Q L
Sbjct: 1338 VP-AKPPRAAAAAAAAAAAPPAPPEGASP----GDSARQKL 1373
Score = 32.3 bits (72), Expect = 5.5
Identities = 38/146 (26%), Positives = 54/146 (36%), Gaps = 14/146 (9%)
Query: 960 GQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGP 1019
G P P+ + LPG P + A V P P+ A AGP
Sbjct: 1241 GSPTPTSKKVPLPG-PGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGS--AGP 1297
Query: 1020 GISPGARKQAWLPADHLSK---VPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSL 1076
+P +Q P L+K P L A+P S L P R ++ ++
Sbjct: 1298 SPAPSPARQ---PPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKP---PRAAAAAAA 1351
Query: 1077 SSAGRPGPSEGGDLDDSDSSLEGLEE 1102
++A P P EG DS+ + LEE
Sbjct: 1352 AAAAPPAPPEGA--SPGDSARQKLEE 1375
>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
Length = 2089
Score = 75.5 bits (184), Expect = 6e-13
Identities = 156/780 (20%), Positives = 250/780 (32%), Gaps = 102/780 (13%)
Query: 1575 PCYSLSSSASSLSEPEP---SEPPAVHPRGREPA-----VTKDPGPGGGRDSSPSPRAAE 1626
PC S + PE +EP + RGR+ + K+ G + P R E
Sbjct: 777 PCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETE 836
Query: 1627 ELLQRCISSALPRRRPPVSG---------------LRRRKPRATRLDERPAEGSRERGEE 1671
+LL P R+ V+G L R + D+ S ER E
Sbjct: 837 KLL--------PERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRE 888
Query: 1672 AAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQ 1731
+ + + + ++ + +Q+ + + + + V + + Q
Sbjct: 889 SLKVEIETS-EEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQ 947
Query: 1732 PPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGR 1791
+ G Q + S+ PE A G P P G+Q G P R
Sbjct: 948 RGEPEGGSQDQKGQASSPTPEPGVGA-----GDLPGPTSAPVPSGSQSGGRGSPVSPRRH 1002
Query: 1792 TVIYVPSPAP--------RAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSL 1843
+ P RA K + G + +P PP + + AP + P Q + + L
Sbjct: 1003 QKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQ-KHL 1061
Query: 1844 HRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGP 1903
P S L +P T + P + S P P+ R + P
Sbjct: 1062 APPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPAT 1121
Query: 1904 GASPVPK---------TPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPR 1954
A+P P TP T A + +T RS V+ P P P L + P
Sbjct: 1122 SAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTP---EPVVPTAPELQPSTSTDQPV 1178
Query: 1955 GRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSA 2014
T R R + + + + E + R +T S R R++
Sbjct: 1179 TSEPTSQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNR---- 1234
Query: 2015 ESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPAR 2074
S+ P+ P +P AP P+ + +P + P+ R
Sbjct: 1235 -SSVKTPE--------PVVPT-------------APELQPSTSTDQPVTSEPTYQATRGR 1272
Query: 2075 RTTSESPSRLPV--RAPAARPETV-----------KRYASLPHISVARRPDGAVPAAPAS 2121
+ S + PV AP RP T + S ++S + P+ VP AP
Sbjct: 1273 KNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPEL 1332
Query: 2122 ADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGP 2181
+ P+P R T +++ + + LP + + TPE
Sbjct: 1333 QISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRAT 1392
Query: 2182 PPRK--TSDAVVQTEEVAAPKTNSSTSPSLE-TREPPGAPAGGQLSLLGSDVDGPSLAKA 2238
RK +S +T APK STS T EP G+ + + A
Sbjct: 1393 RGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTA 1452
Query: 2239 PISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPS--PMVVAATTDSAAEKAPAT 2296
P P V + G RS+ P VP+ + +A+TD P +
Sbjct: 1453 PELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTS 1512
Score = 60.1 bits (144), Expect = 2e-08
Identities = 186/891 (20%), Positives = 289/891 (32%), Gaps = 133/891 (14%)
Query: 1415 PRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPS 1474
P +PG AG PTSA G + +GG G R ++ GL L PP+
Sbjct: 965 PTPEPGVGAG---DLPGPTSAPVPSGSQ--SGGRGSPVSPRR----HQKGL-LNCKMPPA 1014
Query: 1475 APADKDGSKPGRTRGDGALQSLCL--TTPTEEAVYCFYGNDSDEE----PPAAAPT---- 1524
A + + +RGD CL T P A N ++ PP +P
Sbjct: 1015 EKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSI 1074
Query: 1525 -PTHRRTSAI------------------PRAFTRERPQGRKEAPAPSKAAPAAPPPARTQ 1565
PT R+T P+ R R R + AAP P T
Sbjct: 1075 KPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTA 1134
Query: 1566 PSLIADETPPCYSLSSSASSLSEPEPSEP--PAVHP-RGREPAVTKDPGP--GGGRDSSP 1620
+ T ++ SS+ PEP P P + P + VT +P GR S
Sbjct: 1135 QPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRS 1194
Query: 1621 SPRAAEEL------LQRCISSALPRRRPPVS-GLRRRKPRATRLDERPAEGSRERGEEAA 1673
S + E + LQ S+ P P S R RK R++ P + + +
Sbjct: 1195 SVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPST 1254
Query: 1674 GSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGL----SVGST 1729
+D + S T+ R + + ++ L S
Sbjct: 1255 STD--------------QPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRP 1300
Query: 1730 LQPPKHRKGRQAEGEMGSARRPEK--RGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAV 1787
+ P + ++ M S + PE A ++ S S P P+ T ++ + +V
Sbjct: 1301 VTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSV 1360
Query: 1788 LRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPA 1847
+ + + AP P + TP P + G++ S P
Sbjct: 1361 KNPESTVPI---APELPPSTSTEQPVTPE------------PTSRATRGRKNRSSGKTPE 1405
Query: 1848 KTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASP 1907
A +P S P T ++ +T+ +S P V A L ++
Sbjct: 1406 TLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRSSVKTPE---TVVPTAPELQPSTSTD 1462
Query: 1908 VPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARG 1967
P TP T A + +T RS V+ P P P L + P T R
Sbjct: 1463 QPVTPEPTSQATRGRTDRSSVKTPETVVPT---APELQASASTDQPVTSEPTSRTTRGRK 1519
Query: 1968 GRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRR--RSELSSAESAASAPQGAS 2025
R + + + + E + + +T S R R RS + + ES
Sbjct: 1520 NRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQ 1579
Query: 2026 PRRGRPAL--PAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSR 2083
P R L P ++RC R++ + P P A P P T+++ P
Sbjct: 1580 PSTSRNQLVTPEPTSRATRCRTNRSSVK---TPEPVVPTAPEPHP------TTSTDQPVT 1630
Query: 2084 LPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPG 2143
+ + A R +T + P P PA++D + + P A G
Sbjct: 1631 PKLTSRATRRKTNRSSVKTPK-----------PVEPAASD-LEPFTPTDQSVTPEAIAQG 1678
Query: 2144 TTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPP------RKTSDAVVQTEEVA 2197
+ +R V + T P P+ D P P P K A +A
Sbjct: 1679 GQSKTLRSSTVRAMPVPTTPEFQSPV----TTDQPISPEPITQPSCIKRQRAAGNPGSLA 1734
Query: 2198 APKTNSSTSPSLETREPP------GAPAGGQLSLLGSDVDGPSLAKAPISA 2242
AP + S LE + GA + + P L + PI A
Sbjct: 1735 APIDHKPCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHA 1785
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 73.9 bits (180), Expect = 2e-12
Identities = 101/456 (22%), Positives = 166/456 (36%), Gaps = 39/456 (8%)
Query: 1519 PAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPS--LIADETPPC 1576
P+ TP +A+ + +P +EAP A PP A PS L+A+ PP
Sbjct: 295 PSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPS 354
Query: 1577 YSLSSSASSLSE--PEPSE-PPAVHPRG--REPAVTKDP------GPGGGRDSSPS---P 1622
S S +E P P+E P+V G R P+ K P G + +P+ P
Sbjct: 355 AEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEP 414
Query: 1623 RAAEELLQRCISSALPRRRP--PVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASD 1680
EE L + LP P L+ T +E P E +E + +++
Sbjct: 415 PTVEETLAD-VQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAE 473
Query: 1681 LDSV--------EWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQP 1732
+ + E A S T +A A + +E + + + + + ++
Sbjct: 474 IQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEA 533
Query: 1733 PKHRKGRQAEG----EMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVL 1788
P +A+ E + P + + S K +P + P G + T A +
Sbjct: 534 PADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAI 593
Query: 1789 RGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAK 1848
+ + A+ + P A P +V PP + APA+V P + + + +P
Sbjct: 594 QLLAATEASAEEAPAEVQPPPAEEA-PAEVQPPPAEE--APAEVQPPPAEEAPAEVQPPP 650
Query: 1849 TSELATLSQPPRSATPPARLAKTPSSSSSQTSPAS-QPLPRKRPPVTQAAGALPGPGASP 1907
E QPP + PA + P ++ +PA Q LP + P+ + A+ P A
Sbjct: 651 AEEAPAEVQPPPAEEAPAEVQPPP----AEEAPAEVQSLPAEETPIEETLAAVHSPPADD 706
Query: 1908 VPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPP 1943
VP A P + A PPP
Sbjct: 707 VPAEEASVDKHSPPADLLLTEEFPIGEASAEVSPPP 742
Score = 59.3 bits (142), Expect = 4e-08
Identities = 117/527 (22%), Positives = 186/527 (35%), Gaps = 61/527 (11%)
Query: 1777 TQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPG 1836
TQ+T G P +L V P + +G+ + ++ PP + PAK+ P
Sbjct: 219 TQETKKGPPVLLEDELREEVTVPVVQ---EGSAVKKVASAEIEPPSTEK--FPAKIQPPL 273
Query: 1837 QQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQA 1896
+ + + P E QP TP A A ++ ++ S QP P + P+ +
Sbjct: 274 VEEATAKAEPRPAEETHVQVQPSTEETPDAEAA----TAVAENSVKVQPPPAEEAPLVEF 329
Query: 1897 AGALPGPGASPVPKTPARTLLAK--QHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPR 1954
+ P A ++P+ LLA+ + SP P PA PPP ++
Sbjct: 330 PAEIQPPSAE---ESPSVELLAEILPPSAEESPSEEP----PAEILPPPAEKSPSVE--- 379
Query: 1955 GRAGTEAGPGARGGRLGL--VRVASALSSGSESSDRSGFRRQLTFI-----KESPGLRRR 2007
G P A+ + + + AL + L + +E+P R
Sbjct: 380 -LLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEAR 438
Query: 2008 RSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPS 2067
+LS +A P +P + LP E++ P PA + P AR
Sbjct: 439 ELQLS---TAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEP-PADETPAEAR-- 492
Query: 2068 PGERPARRTTSESPSRLPVRAPAARPETVKR-YASLPHISVARRPDGAVPAAPASADAAR 2126
P TS + V++P A T + A + ++ P PA S +
Sbjct: 493 ---SPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEE 549
Query: 2127 RSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATA------LPLRGSTPEDAPA- 2179
S++ P + +A G + E P T A L ++ E+APA
Sbjct: 550 TSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAE 609
Query: 2180 -GPPPRKTSDAVVQ----TEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPS 2234
PPP + + A VQ E A + + E + PP A ++V P
Sbjct: 610 VQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEA-------PAEVQPPP 662
Query: 2235 LAKAPISA-PFVHEGLGVAVGGFPASRHGSPSRSARV--PPFNYVPS 2278
+AP P E V PA A V PP + VP+
Sbjct: 663 AEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPA 709
Score = 48.5 bits (114), Expect = 7e-05
Identities = 69/276 (25%), Positives = 102/276 (36%), Gaps = 48/276 (17%)
Query: 1379 APAPAQEDDSCTDS--------AEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTG 1430
A +P E+ S ++ AE T +SA ++ P + P A Q P
Sbjct: 491 ARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETP---AEAQSPLS 547
Query: 1431 RPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGD 1490
TSA +A G S E+ A LEL +PPS G +
Sbjct: 548 EETSAEEAPAEVQSPSAKGVSIEE--------APLEL---QPPS------GEETTAEEAS 590
Query: 1491 GALQSLCLTT-------------PTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAF 1537
A+Q L T P EEA ++E P P P + +
Sbjct: 591 AAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPP 650
Query: 1538 TRERPQGRKEAPAPSKAAPAAPPPARTQP----SLIADETPPCYSLSSSASSLSEPEPSE 1593
E P + PA A PPPA P SL A+ETP +L++ S ++ P+E
Sbjct: 651 AEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPPADDVPAE 710
Query: 1594 PPAV--HPRGREPAVTKDPGPGGGRDSSPSPRAAEE 1627
+V H + +T++ P G + SP +E+
Sbjct: 711 EASVDKHSPPADLLLTEE-FPIGEASAEVSPPPSEQ 745
Score = 47.8 bits (112), Expect = 1e-04
Identities = 66/270 (24%), Positives = 99/270 (36%), Gaps = 27/270 (10%)
Query: 961 QPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLL-EGASRAGAEPLAGP 1019
QP P+ L+ + EPP E T AD + PLL E A R A L
Sbjct: 397 QPLPAEGALEEAPAKVEPPTVEETLADVQ-------------PLLPEEAPREEARELQLS 443
Query: 1020 GISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSA 1079
++A P + S +P++ A AS +Q LAA E P + + S LS
Sbjct: 444 TAMETPAEEA--PTEFQSPLPKETTA---EEASAEIQLLAATEPPADETPAEARSPLSE- 497
Query: 1080 GRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPG-ATSLPVAIPAPRRNRGRGLG 1138
E S + E E +E +L + AP T P
Sbjct: 498 -ETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAP 556
Query: 1139 VEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSEL 1198
E +PS+ + ++E PL L S + S +I +E + + + P
Sbjct: 557 AEVQSPSAKGVS-IEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPA 615
Query: 1199 PDSPGQTMPPSRSKTPPLAPAPQGPPEATQ 1228
++P + PP + APA PP A +
Sbjct: 616 EEAPAEVQPPPAEE----APAEVQPPPAEE 641
Score = 45.1 bits (105), Expect = 8e-04
Identities = 71/292 (24%), Positives = 102/292 (34%), Gaps = 43/292 (14%)
Query: 1373 VYMLVPAPAPAQE------DDSCTDSAEGTPVNFSSA---------ASLSDETLQG--PP 1415
V L+P AP +E + AE P F S AS + L PP
Sbjct: 424 VQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEPP 483
Query: 1416 RDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSA 1475
D+ PA + P TSA +A +AE++ + A +E P P+
Sbjct: 484 ADET--PAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAE 541
Query: 1476 PADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPR 1535
+ +QS P+ + V S EE P P+ T+A
Sbjct: 542 AQSPLSEETSAEEAPAEVQS-----PSAKGV-------SIEEAPLELQPPSGEETTA-EE 588
Query: 1536 AFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSE-- 1593
A + EA A A PPPA P+ + + PP + A + +P P+E
Sbjct: 589 ASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEV--QPPP----AEEAPAEVQPPPAEEA 642
Query: 1594 PPAVHPRGREPAVTK-DPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPV 1644
P V P E A + P P + P AEE +LP P+
Sbjct: 643 PAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEV--QSLPAEETPI 692
Score = 37.0 bits (84), Expect = 0.22
Identities = 79/385 (20%), Positives = 132/385 (34%), Gaps = 51/385 (13%)
Query: 1751 PEKRGAASVKTSGSPRSPAGPEKPRGTQK-----TTPGVPAVLRGRTVIYVPSPAPRAQP 1805
P + SV+ G RSP+ + P Q PA + TV + P
Sbjct: 370 PPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLP 429
Query: 1806 KGTPGPRATPRKVAPPCLAQPA--APAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSAT 1863
+ P A +++ + PA AP + SP + + + A+ LA ++PP T
Sbjct: 430 EEAPREEARELQLST-AMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAA-TEPPADET 487
Query: 1864 PPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGA---LPGPGASPVPKTPA--RTLLA 1918
P + +S++ + A P + A A L +P +TPA ++ L+
Sbjct: 488 PAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLS 547
Query: 1919 KQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASA 1978
++ + +P + Q P+ +G + P G T A
Sbjct: 548 EETSAEEAPAEV---QSPSAKGVSIEEAPLELQPPSGEETTAEEASA---------AIQL 595
Query: 1979 LSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFL 2038
L++ S++ + Q +E+P + + P +P +P PA
Sbjct: 596 LAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPP-PA--- 651
Query: 2039 CSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKR 2098
EE A + P PA + P +P P E S P+ A
Sbjct: 652 -----EEAPAEVQ--PPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLA------- 697
Query: 2099 YASLPHISVARRPDGAVPAAPASAD 2123
+V P VPA AS D
Sbjct: 698 -------AVHSPPADDVPAEEASVD 715
Score = 33.5 bits (75), Expect = 2.5
Identities = 55/253 (21%), Positives = 88/253 (34%), Gaps = 38/253 (15%)
Query: 2056 PARQRPPAARPSPGERPARRTTSESPSRLPVRAPAAR--PETVKRYASLPHISVARRPDG 2113
PA +PP+A SP S P P A P ++ S+ + R P
Sbjct: 330 PAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSP-- 387
Query: 2114 AVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGST 2173
+ AP E +PLP A +E + T+ T ++
Sbjct: 388 SAQKAPI-----------EVQPLPAEGA--------LEEAPAKVEPPTVEETLADVQPLL 428
Query: 2174 PEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDV--- 2230
PE+AP ++T AP S P T E A ++ LL +
Sbjct: 429 PEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAE----EASAEIQLLAATEPPA 484
Query: 2231 -DGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARV-------PPFNYVPSPMVV 2282
+ P+ A++P+S E V A + SA + P + P+
Sbjct: 485 DETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQS 544
Query: 2283 AATTDSAAEKAPA 2295
+ +++AE+APA
Sbjct: 545 PLSEETSAEEAPA 557
>gi|145199237 transcription elongation factor B polypeptide 3 binding
protein 1 [Homo sapiens]
Length = 1221
Score = 73.9 bits (180), Expect = 2e-12
Identities = 186/810 (22%), Positives = 286/810 (35%), Gaps = 157/810 (19%)
Query: 1419 PGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPAD 1478
PGGP R R AR + A G G A + G G + ELP +PP+
Sbjct: 20 PGGPCRRPYCHFRHRGARGS-----GAPGDGGEAPPAAGLGYDPYNPELP--KPPA---- 68
Query: 1479 KDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFT 1538
+ T G G P + + N + E + R +
Sbjct: 69 ---QRENGTLGLGE-------EPRPDVLELELVNQAIEAVRSEVELEQRRYRELLETTRE 118
Query: 1539 RERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVH 1598
+ AP A+P P P L D +P + L S + +P P PA
Sbjct: 119 HRSAEAPALAPRGPNASPTVGPDEDAFP-LAFDYSPGSHGLLSPDAGY-QPTPLAAPA-E 175
Query: 1599 PRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGL----------- 1647
P + + D G G G A E + + +S RP SG
Sbjct: 176 PGSKYSLASLDRGQGRGGGGG----GALEYVPKAVSQPRRHSRPVPSGKYVVDNSRPPTD 231
Query: 1648 ----------RRRKPRATRLDERPAEGSR-ERGEEAA-----------GSDRASDLDSVE 1685
R RA+ DER A+ R RG E GS A DS +
Sbjct: 232 LEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCDPFGSCDARFSDSED 291
Query: 1686 WRAIQEGANSIVTWLHQAAA-----ATREASSESDSILSFVSGL----------SVGSTL 1730
A G +A A AT + S+ + + + GL VG L
Sbjct: 292 EAATVPGNEPTTASTPKARADPEIKATGQPPSK-EGLEAEGGGLRETKETAVQCDVGD-L 349
Query: 1731 QPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRG 1790
QPP + A+ + K G K +G+P +P+ + +G KT RG
Sbjct: 350 QPPPAKPASPAQVQSSQDGGCPKEGKPKKKKTGAPPAPSCKDGAQGKDKTKDKG----RG 405
Query: 1791 RTV---------IYVPSPAPRAQ-PKGTPGPRATPRKVAPPCLAQPAAPAKVPSP--GQQ 1838
R V SP +A+ P+GT ++ VA +P PA+ PSP G
Sbjct: 406 RPVEKPRADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDS 465
Query: 1839 RSRSLHRPAKTSELATLSQPPRSAT--PPARLAKTPSSSSSQTSPASQPLPRKRPPV--- 1893
R + P + +L P R +T P +L + + S + + P +KR
Sbjct: 466 RPAAGRGPPRPLQL-----PDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHAD 520
Query: 1894 ---TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPE 1950
++ GPG V + +L + S + P Q GPP +A P
Sbjct: 521 LFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQ-----GPPKRLKASPP 575
Query: 1951 PGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTF----IKESPGLRR 2006
P P + + + +S+ SS D S +++ F ++E +
Sbjct: 576 PSPAPSSSSSS--------------SSSTSSAGADVDYSALEKEVDFDSDPMEECLRIFN 621
Query: 2007 RRSELSSAESAASAPQ----GASPRRGRPALPAVF--------LCSSRCEELRAAPRQGP 2054
+ + + + A Q S +G L +F S + +E+ PR+GP
Sbjct: 622 ESTSVKTEDRGRLARQPPKEEKSEEKGLSGLTTLFPGQKRRISHLSKQGQEVE-PPRRGP 680
Query: 2055 APARQRPPAA------RPSPGERPARRTTSESPSRLPVRAPA---ARPETVKRYASLPHI 2105
A RPP A R +R A + ++P+RL ++P+ + P +R A +P+
Sbjct: 681 AVPPARPPTAQEVCYLRAQQAQR-ASASLLQAPARLAEKSPSVHISAPGEKRRIAHIPNP 739
Query: 2106 SVARRPDGAVPAAPASADAARRSSDGEPRP 2135
+A P GA AS +SS+G P P
Sbjct: 740 RLAAAPTGAKRTLAASGS---QSSNG-PEP 765
Score = 52.8 bits (125), Expect = 4e-06
Identities = 130/596 (21%), Positives = 198/596 (33%), Gaps = 113/596 (18%)
Query: 1364 PGRRALPVPV--YMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGG 1421
P R + PVP Y++ + P D D S AS DE PR G
Sbjct: 209 PRRHSRPVPSGKYVVDNSRPPT---DLEYDPLSNYSARHLSRASSRDERAAKRPR----G 261
Query: 1422 PAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDG 1481
G + T P G S G E P A AD +
Sbjct: 262 SRGSEPYTPAPKKLCDPFG------SCDARFSDSEDEAATVPGNEPTTASTPKARADPEI 315
Query: 1482 SKPGRTRGDGALQSLC--LTTPTEEAVYCFYGNDSDEEPPAAAPT--------------- 1524
G+ L++ L E AV C G D +PP A P
Sbjct: 316 KATGQPPSKEGLEAEGGGLRETKETAVQCDVG---DLQPPPAKPASPAQVQSSQDGGCPK 372
Query: 1525 ---PTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSS 1581
P ++T A P ++ QG+ + + P P A + + P
Sbjct: 373 EGKPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKGP---QASSPRRKAER 429
Query: 1582 SASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRR- 1640
+ +P + P A +GR + P P G + R LQ LP R
Sbjct: 430 PEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPLQ------LPDRK 483
Query: 1641 --RPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDL--DSVEWRAIQEGANSI 1696
+ P L RK R+ LDE ++ + + + A +DL D E A G S+
Sbjct: 484 STKAPSGKLVERKARS--LDEGASQDAPKLKKRALSH---ADLFGDESEDEAAGPGVPSV 538
Query: 1697 VTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGR-----QAEGEMGSARRP 1751
W + + ++ S+SDS L F PPK K S+
Sbjct: 539 --WPSALPSLSSDSDSDSDSSLGFPEAQG------PPKRLKASPPPSPAPSSSSSSSSST 590
Query: 1752 EKRGA----------------------------ASVKTSGSPR-SPAGPEKPRGTQKTTP 1782
GA SVKT R + P++ + +K
Sbjct: 591 SSAGADVDYSALEKEVDFDSDPMEECLRIFNESTSVKTEDRGRLARQPPKEEKSEEKGLS 650
Query: 1783 GVPAVLRG--RTVIYVPSPAPRAQP--KGTPGPRATPRKVAPPCL-----AQPAAPAKVP 1833
G+ + G R + ++ +P +G P A P C AQ A+ + +
Sbjct: 651 GLTTLFPGQKRRISHLSKQGQEVEPPRRGPAVPPARPPTAQEVCYLRAQQAQRASASLLQ 710
Query: 1834 SPGQ--QRSRSLH--RPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQP 1885
+P + ++S S+H P + +A + PR A P +T ++S SQ+S +P
Sbjct: 711 APARLAEKSPSVHISAPGEKRRIAHIPN-PRLAAAPTGAKRTLAASGSQSSNGPEP 765
Score = 42.0 bits (97), Expect = 0.007
Identities = 71/327 (21%), Positives = 116/327 (35%), Gaps = 61/327 (18%)
Query: 1943 PLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESP 2002
P ARA PE G+ ++ G A GG G + + + + ++ P
Sbjct: 307 PKARADPEIKATGQPPSKEGLEAEGG-------------GLRETKETAVQCDVGDLQPPP 353
Query: 2003 GLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPP 2062
+++ S++ P+ P++ + P C + G +
Sbjct: 354 AKPASPAQVQSSQD-GGCPKEGKPKKKKTGAPPAPSC-----------KDGAQGKDKTKD 401
Query: 2063 AARPSPGERPARRTTSESPSRLPVRAPAARPE-TVKRYASLPHISVA--RRPD-GAVPAA 2118
R P E+P R + P R A RPE T K+ +S ++ + RPD A +
Sbjct: 402 KGRGRPVEKP--RADKKGPQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPS 459
Query: 2119 PASADAARRSSDGEPRPL-------PRVAAPGTTWRRIR------DEDVPHILRSTLPAT 2165
P S D+ + G PRPL + + R+ R +D P + + L +
Sbjct: 460 PTSGDSRPAAGRGPPRPLQLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRAL--S 517
Query: 2166 ALPLRGSTPEDAPAGPP---------PRKTSDAVVQTE------EVAAPKTNSSTSPSLE 2210
L G ED AGP P +SD+ ++ E P SP
Sbjct: 518 HADLFGDESEDEAAGPGVPSVWPSALPSLSSDSDSDSDSSLGFPEAQGPPKRLKASPPPS 577
Query: 2211 TREPPGAPAGGQLSLLGSDVDGPSLAK 2237
+ + S G+DVD +L K
Sbjct: 578 PAPSSSSSSSSSTSSAGADVDYSALEK 604
Score = 36.2 bits (82), Expect = 0.38
Identities = 67/241 (27%), Positives = 92/241 (38%), Gaps = 25/241 (10%)
Query: 2010 ELSSAESAASAPQG--ASPRRG--RPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAAR 2065
E SAE+ A AP+G ASP G A P F S L +P G P P AA
Sbjct: 118 EHRSAEAPALAPRGPNASPTVGPDEDAFPLAFDYSPGSHGL-LSPDAGYQPT---PLAAP 173
Query: 2066 PSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAA 2125
PG + + + R A E V + S P RR VP+ D +
Sbjct: 174 AEPGSKYSLASLDRGQGRGGGGGGAL--EYVPKAVSQP-----RRHSRPVPSGKYVVDNS 226
Query: 2126 RRSSDGEPRPLPRVAAPGTTWRRIRDEDV---PHILRSTLPATALPLRGSTPEDAPAGPP 2182
R +D E PL +A + RDE P R + P T P + P G
Sbjct: 227 RPPTDLEYDPLSNYSARHLSRASSRDERAAKRPRGSRGSEPYTPAPKKLCD----PFGSC 282
Query: 2183 PRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQ-LSLLGSDVDGPSLAKAPIS 2241
+ SD+ + E P +T+ + + R P A GQ S G + +G L + +
Sbjct: 283 DARFSDS--EDEAATVPGNEPTTASTPKARADPEIKATGQPPSKEGLEAEGGGLRETKET 340
Query: 2242 A 2242
A
Sbjct: 341 A 341
Score = 32.0 bits (71), Expect = 7.2
Identities = 66/286 (23%), Positives = 97/286 (33%), Gaps = 22/286 (7%)
Query: 948 AALASRREDPRC---GQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPL 1004
A+ R DP GQP PS+ L+ G A D V ++ P P
Sbjct: 304 ASTPKARADPEIKATGQP-PSKEGLEAEGGGLRETKETAVQCD--VGDLQPPPAKPASPA 360
Query: 1005 LEGASRAGAEPLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGP 1064
+S+ G P G P +K PA + + ++K A +
Sbjct: 361 QVQSSQDGGCPKEG---KPKKKKTGAPPAPSCKDGAQGKDKTKDKGRGRPVEKPRADKKG 417
Query: 1065 LSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPV 1124
S + + PS + S PS DS A P+
Sbjct: 418 PQASSPRRKAERPEGTKKKPSSATPVATSGKGRPDRPARRPSPTSGDSRPAAGRGPPRPL 477
Query: 1125 AIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFES------PSIAS 1178
+P + + + + S E Q+ P + R S + L ES P + S
Sbjct: 478 QLPDRKSTKAPSGKLVERKARSLDEGASQDAPKLKKRALSHADLFGDESEDEAAGPGVPS 537
Query: 1179 SIPSE-PCSGQGSGTISPSEL--PDSPGQTMPPSRSK-TPPLAPAP 1220
PS P S + S S L P++ G PP R K +PP +PAP
Sbjct: 538 VWPSALPSLSSDSDSDSDSSLGFPEAQG---PPKRLKASPPPSPAP 580
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 109,588,336
Number of Sequences: 37866
Number of extensions: 6863531
Number of successful extensions: 67478
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 2655
Number of HSP's that attempted gapping in prelim test: 34110
Number of HSP's gapped (non-prelim): 25424
length of query: 2303
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2185
effective length of database: 13,779,330
effective search space: 30107836050
effective search space used: 30107836050
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.