Guide to the Human Genome
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Search of human proteins with 50233824

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50233824 ring finger and WD repeat domain 2 isoform d24
[Homo sapiens]
         (707 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo...  1431   0.0  
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s...  1413   0.0  
gi|23199987 WD repeat domain 5B [Homo sapiens]                         92   2e-18
gi|16554629 WD repeat domain 5 [Homo sapiens]                          91   4e-18
gi|16554627 WD repeat domain 5 [Homo sapiens]                          91   4e-18
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     87   7e-17
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    75   3e-13
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    75   3e-13
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    75   3e-13
gi|26665869 WD repeat domain 51B [Homo sapiens]                        75   3e-13
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             73   1e-12
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     71   3e-12
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              67   6e-11
gi|32189425 WD repeat domain 69 [Homo sapiens]                         64   5e-10
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             64   6e-10
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             64   6e-10
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             64   6e-10
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     62   1e-09
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    62   2e-09
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               62   2e-09
gi|113865883 WD repeat domain 38 [Homo sapiens]                        62   2e-09
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    62   2e-09
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...    61   3e-09
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...    61   3e-09
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...    61   3e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     61   3e-09
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     61   3e-09
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     61   3e-09
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    61   4e-09
gi|5902034 periodic tryptophan protein 1 [Homo sapiens]                61   4e-09

>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
           sapiens]
          Length = 707

 Score = 1431 bits (3703), Expect = 0.0
 Identities = 707/707 (100%), Positives = 707/707 (100%)

Query: 1   MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG 60
           MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG
Sbjct: 1   MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG 60

Query: 61  LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC 120
           LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC
Sbjct: 61  LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC 120

Query: 121 NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI 180
           NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
Sbjct: 121 NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI 180

Query: 181 DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLEL 240
           DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLEL
Sbjct: 181 DHLYPNFLVNELILKQKQRFEEKRFKLDHSNGHRWQIFQDWLGTDQDNLDLANVNLMLEL 240

Query: 241 LVQKKKQLEAESHAAQLQILMEFLKVARRNKREEMSGLYSPVSEDSTVPQFEAPSPSHSS 300
           LVQKKKQLEAESHAAQLQILMEFLKVARRNKREEMSGLYSPVSEDSTVPQFEAPSPSHSS
Sbjct: 241 LVQKKKQLEAESHAAQLQILMEFLKVARRNKREEMSGLYSPVSEDSTVPQFEAPSPSHSS 300

Query: 301 IIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSR 360
           IIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSR
Sbjct: 301 IIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQCYFSTRMSRISDDSR 360

Query: 361 TASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKK 420
           TASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKK
Sbjct: 361 TASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKK 420

Query: 421 IKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQ 480
           IKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQ
Sbjct: 421 IKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQ 480

Query: 481 RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS 540
           RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS
Sbjct: 481 RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS 540

Query: 541 PSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKL 600
           PSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKL
Sbjct: 541 PSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKL 600

Query: 601 WNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVK 660
           WNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVK
Sbjct: 601 WNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVK 660

Query: 661 SVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV 707
           SVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV
Sbjct: 661 SVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV 707


>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
           sapiens]
          Length = 731

 Score = 1413 bits (3657), Expect = 0.0
 Identities = 707/731 (96%), Positives = 707/731 (96%), Gaps = 24/731 (3%)

Query: 1   MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG 60
           MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG
Sbjct: 1   MSGSRQAGSGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGG 60

Query: 61  LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC 120
           LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC
Sbjct: 61  LGGPVRPVLVAPAVSGSGGGAVSTGLSRHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLC 120

Query: 121 NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI 180
           NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI
Sbjct: 121 NGLINSYEDKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNI 180

Query: 181 DHLYPNFLVNELILKQKQRFEEKRFKLDHS----NGHRWQIFQDWLGTDQDNLDLANVNL 236
           DHLYPNFLVNELILKQKQRFEEKRFKLDHS    NGHRWQIFQDWLGTDQDNLDLANVNL
Sbjct: 181 DHLYPNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANVNL 240

Query: 237 MLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKRE--------------------EMS 276
           MLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKRE                    EMS
Sbjct: 241 MLELLVQKKKQLEAESHAAQLQILMEFLKVARRNKREQLEQIQKELSVLEEDIKRVEEMS 300

Query: 277 GLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRL 336
           GLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRL
Sbjct: 301 GLYSPVSEDSTVPQFEAPSPSHSSIIDSTEYSQPPGFSGSSQTKKQPWYNSTLASRRKRL 360

Query: 337 TAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNG 396
           TAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNG
Sbjct: 361 TAHFEDLEQCYFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNG 420

Query: 397 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS 456
           SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS
Sbjct: 421 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS 480

Query: 457 YHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKL 516
           YHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKL
Sbjct: 481 YHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKL 540

Query: 517 WSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRK 576
           WSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRK
Sbjct: 541 WSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRK 600

Query: 577 AVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE 636
           AVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE
Sbjct: 601 AVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE 660

Query: 637 NNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAAN 696
           NNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAAN
Sbjct: 661 NNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAAN 720

Query: 697 SQGTIKVLELV 707
           SQGTIKVLELV
Sbjct: 721 SQGTIKVLELV 731


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 73/258 (28%), Positives = 127/258 (49%), Gaps = 19/258 (7%)

Query: 393 LYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCI 452
           L   +  VSS++F  + ++ A +   + I       +I  A D  Y +     N +IS +
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLI-------IIWGAYDGKYEKTLYGHNLEISDV 89

Query: 453 SWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDA 512
           +WSS    L+++SD + T+ LWD  +G+  K  + H    +  +FN     L+ SGS D 
Sbjct: 90  AWSSDSSRLVSASD-DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN-PPSNLIISGSFDE 147

Query: 513 KVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVF 571
            VK+W       + ++ A ++ V  V F+ S    +  G  D     +D  + +    + 
Sbjct: 148 TVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSL-IVSGSYDGLCRIWDAASGQCLKTLV 206

Query: 572 KGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK-----NFVGLA 625
                 VS+ KF  +G+ I++A+ D+ LKLW+  +  CL+++ GH NEK     NF    
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF--SV 264

Query: 626 SNGDYIACGSENNSLYLY 643
           + G +I  GSE+N +Y++
Sbjct: 265 TGGKWIVSGSEDNLVYIW 282



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 55/196 (28%), Positives = 90/196 (45%), Gaps = 6/196 (3%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           LASS  +  +I+W  + G+  K    H      V ++  D   L S SDD  +KLW    
Sbjct: 56  LASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS-SDSSRLVSASDDKTLKLWDVRS 114

Query: 522 DNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 580
              + +++  +N V C  F+P S   ++ G  D  V  ++++ T + +     H   VS 
Sbjct: 115 GKCLKTLKGHSNYVFCCNFNPPSNLIIS-GSFDETVKIWEVK-TGKCLKTLSAHSDPVSA 172

Query: 581 AKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK-NFVGLASNGDYIACGSENN 638
             F  SG  IVS S D   ++W+     CL++     N   +FV  + NG YI   + +N
Sbjct: 173 VHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN 232

Query: 639 SLYLYYKGLSKTLLTF 654
           +L L+     + L T+
Sbjct: 233 TLKLWDYSRGRCLKTY 248



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 3/121 (2%)

Query: 534 VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSA 592
           V  VKFSP+  + LA   AD  +  +   + K    ++ GH   +S   + S    +VSA
Sbjct: 44  VSSVKFSPNGEW-LASSSADRLIIIWGAYDGKYEKTLY-GHNLEISDVAWSSDSSRLVSA 101

Query: 593 STDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLL 652
           S D  LKLW+V    CL++ KGH N           + I  GS + ++ ++     K L 
Sbjct: 102 SDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLK 161

Query: 653 T 653
           T
Sbjct: 162 T 162



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 3/91 (3%)

Query: 446 NSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEH--EKRCWSVDFNLMDPK 503
           N  +S + +S   K +L ++  + T+ LWD   G+  K Y  H  EK C   +F++   K
Sbjct: 210 NPPVSFVKFSPNGKYILTAT-LDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK 268

Query: 504 LLASGSDDAKVKLWSTNLDNSVASIEAKANV 534
            + SGS+D  V +W+      V  ++   +V
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDV 299



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 1/84 (1%)

Query: 573 GHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYI 631
           GH +AVS  KF  +GE + S+S D  + +W        ++  GH  E + V  +S+   +
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 632 ACGSENNSLYLYYKGLSKTLLTFK 655
              S++ +L L+     K L T K
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLK 122


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 74/271 (27%), Positives = 129/271 (47%), Gaps = 23/271 (8%)

Query: 381 VRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVY-EYDTVIQDAVDIHYP 439
           V+P   L +   L   +  VSS++F  + ++ A +   K IK++  YD   +  +  H  
Sbjct: 31  VKPNYALKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-- 86

Query: 440 ENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNL 499
                    IS ++WSS   NLL S+  + T+ +WD  +G+  K  + H    +  +FN 
Sbjct: 87  ------KLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139

Query: 500 MDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHY 558
               L+ SGS D  V++W       + ++ A ++ V  V F+      +     D     
Sbjct: 140 QS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL-IVSSSYDGLCRI 197

Query: 559 YDLRNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHIN 617
           +D  + +    +       VS+ KF  +G+ I++A+ D+ LKLW+  K  CL+++ GH N
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257

Query: 618 EK-----NFVGLASNGDYIACGSENNSLYLY 643
           EK     NF    + G +I  GSE+N +Y++
Sbjct: 258 EKYCIFANF--SVTGGKWIVSGSEDNLVYIW 286



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 55/196 (28%), Positives = 91/196 (46%), Gaps = 6/196 (3%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           LASS  +  + +W  + G+  K    H+     V ++  D  LL S SDD  +K+W  + 
Sbjct: 60  LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 118

Query: 522 DNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 580
              + +++  +N V C  F+P S   +  G  D  V  +D++ T + +     H   VS 
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSA 176

Query: 581 AKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK-NFVGLASNGDYIACGSENN 638
             F   G  IVS+S D   ++W+     CL++     N   +FV  + NG YI   + +N
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236

Query: 639 SLYLYYKGLSKTLLTF 654
           +L L+     K L T+
Sbjct: 237 TLKLWDYSKGKCLKTY 252



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 3/121 (2%)

Query: 534 VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEI-VSA 592
           V  VKFSP+  + LA   AD  +  +   + K    +  GH+  +S   + S   + VSA
Sbjct: 48  VSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSA 105

Query: 593 STDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLL 652
           S D  LK+W+V    CL++ KGH N           + I  GS + S+ ++     K L 
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 653 T 653
           T
Sbjct: 166 T 166



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 9/140 (6%)

Query: 397 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS 456
           S  VS++ F+RD      +      +++  DT     +     ++    N  +S + +S 
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIW--DTASGQCLKTLIDDD----NPPVSFVKFSP 224

Query: 457 YHKNLLASSDYEGTVILWDGFTGQRSKVYQEH--EKRCWSVDFNLMDPKLLASGSDDAKV 514
             K +LA++  + T+ LWD   G+  K Y  H  EK C   +F++   K + SGS+D  V
Sbjct: 225 NGKYILAAT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283

Query: 515 KLWSTNLDNSVASIEAKANV 534
            +W+      V  ++   +V
Sbjct: 284 YIWNLQTKEIVQKLQGHTDV 303



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 1/84 (1%)

Query: 573 GHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYI 631
           GH KAVS  KF  +GE + S+S D  +K+W        ++  GH    + V  +S+ + +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 632 ACGSENNSLYLYYKGLSKTLLTFK 655
              S++ +L ++     K L T K
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLK 126


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 74/271 (27%), Positives = 129/271 (47%), Gaps = 23/271 (8%)

Query: 381 VRPLATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVY-EYDTVIQDAVDIHYP 439
           V+P   L +   L   +  VSS++F  + ++ A +   K IK++  YD   +  +  H  
Sbjct: 31  VKPNYALKFT--LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-- 86

Query: 440 ENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNL 499
                    IS ++WSS   NLL S+  + T+ +WD  +G+  K  + H    +  +FN 
Sbjct: 87  ------KLGISDVAWSS-DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP 139

Query: 500 MDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHY 558
               L+ SGS D  V++W       + ++ A ++ V  V F+      +     D     
Sbjct: 140 QS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL-IVSSSYDGLCRI 197

Query: 559 YDLRNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHIN 617
           +D  + +    +       VS+ KF  +G+ I++A+ D+ LKLW+  K  CL+++ GH N
Sbjct: 198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257

Query: 618 EK-----NFVGLASNGDYIACGSENNSLYLY 643
           EK     NF    + G +I  GSE+N +Y++
Sbjct: 258 EKYCIFANF--SVTGGKWIVSGSEDNLVYIW 286



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 55/196 (28%), Positives = 91/196 (46%), Gaps = 6/196 (3%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           LASS  +  + +W  + G+  K    H+     V ++  D  LL S SDD  +K+W  + 
Sbjct: 60  LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS-SDSNLLVSASDDKTLKIWDVSS 118

Query: 522 DNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 580
              + +++  +N V C  F+P S   +  G  D  V  +D++ T + +     H   VS 
Sbjct: 119 GKCLKTLKGHSNYVFCCNFNPQSNL-IVSGSFDESVRIWDVK-TGKCLKTLPAHSDPVSA 176

Query: 581 AKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK-NFVGLASNGDYIACGSENN 638
             F   G  IVS+S D   ++W+     CL++     N   +FV  + NG YI   + +N
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236

Query: 639 SLYLYYKGLSKTLLTF 654
           +L L+     K L T+
Sbjct: 237 TLKLWDYSKGKCLKTY 252



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 37/121 (30%), Positives = 56/121 (46%), Gaps = 3/121 (2%)

Query: 534 VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEI-VSA 592
           V  VKFSP+  + LA   AD  +  +   + K    +  GH+  +S   + S   + VSA
Sbjct: 48  VSSVKFSPNGEW-LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSA 105

Query: 593 STDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLL 652
           S D  LK+W+V    CL++ KGH N           + I  GS + S+ ++     K L 
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 653 T 653
           T
Sbjct: 166 T 166



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 35/140 (25%), Positives = 64/140 (45%), Gaps = 9/140 (6%)

Query: 397 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS 456
           S  VS++ F+RD      +      +++  DT     +     ++    N  +S + +S 
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIW--DTASGQCLKTLIDDD----NPPVSFVKFSP 224

Query: 457 YHKNLLASSDYEGTVILWDGFTGQRSKVYQEH--EKRCWSVDFNLMDPKLLASGSDDAKV 514
             K +LA++  + T+ LWD   G+  K Y  H  EK C   +F++   K + SGS+D  V
Sbjct: 225 NGKYILAAT-LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283

Query: 515 KLWSTNLDNSVASIEAKANV 534
            +W+      V  ++   +V
Sbjct: 284 YIWNLQTKEIVQKLQGHTDV 303



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 1/84 (1%)

Query: 573 GHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYI 631
           GH KAVS  KF  +GE + S+S D  +K+W        ++  GH    + V  +S+ + +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 632 ACGSENNSLYLYYKGLSKTLLTFK 655
              S++ +L ++     K L T K
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLK 126


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 170/795 (21%), Positives = 298/795 (37%), Gaps = 138/795 (17%)

Query: 7   AGSGSAGTS---PGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGG 63
           AG GS GT+   P     +   S+S+        P+VAVSAAA        AA       
Sbjct: 32  AGEGSGGTTNNGPNGGGGNVAASSSTGGDGGTPKPTVAVSAAAPAGAAPVPAAAPDAGAP 91

Query: 64  PVRPVLVA-------------------------PAVSGSG--------GGAVSTGLSRHS 90
             R  L+A                          AV+GSG        G  V++ L    
Sbjct: 92  HDRQTLLAVLQFLRQSKLREAEEALRREAGLLEEAVAGSGAPGEVDSAGAEVTSALLSRV 151

Query: 91  CAARPSA------GVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFVCPICFDMIE 144
            A+ P        G G S +++ SGS   P  AP   G + + ED+ +          + 
Sbjct: 152 TASAPGPAAPDPPGTGASGATVVSGSASGPA-APGKVGSV-AVEDQPD-------VSAVL 202

Query: 145 EAYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNFLVNELILKQKQRFEEKR 204
            AY  + G    Y+  +  L+    C    +  +     YP F+   L L   Q   E +
Sbjct: 203 SAYNQQ-GDPTMYEEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAK 261

Query: 205 FKLDHSNGHRWQIFQDWLGT------------DQDNLDLANVNLMLELLVQK----KKQL 248
              +  +G +   +QD L              ++  LD      +L +        K+ L
Sbjct: 262 SFFEKFHGDQECYYQDDLRVLSSLTKKEHMKGNETMLDFRTSKFVLRISRDSYQLLKRHL 321

Query: 249 EAESHAAQLQILMEFLKV-----ARRNKRE------EMSGLYSPVSEDSTV-------PQ 290
           + + +     I+ E L +       R+K++       ++G     +  S V       P+
Sbjct: 322 QEKQNNQIWNIVQEHLYIDIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPE 381

Query: 291 FEAPSPSHSSIIDSTE----YSQPPGFSGSSQTKKQPWYNSTLASRRKRLTAHFEDLEQC 346
            E P        ++ E      +P   S  S++KKQ       A  + R+      L + 
Sbjct: 382 IEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQ----DPNAPPQNRIP-----LPEL 432

Query: 347 YFSTRMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFD 406
             S ++ +I +   T  ++    +CL     Y  +     L+ A D+ + SS+++    D
Sbjct: 433 KDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLT-AVDVTDDSSLIAGGFAD 491

Query: 407 RDCDYFAIAGVTKKIKVY-----------EYDTVIQDAVDIHYPENEMTCNSKISCISWS 455
                +++    KK++             E D V++  +D                +  +
Sbjct: 492 STVRVWSVT--PKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGA 549

Query: 456 SYH--KNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAK 513
           S+   +N L SS  +GTV LW   T      Y+ H    W   F+        SG  D  
Sbjct: 550 SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRV 608

Query: 514 VKLWSTNLDNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFK 572
            +LW+T+    +       A+V C +F P+S Y +A G AD  V  +D+ N    + +F 
Sbjct: 609 ARLWATDHYQPLRIFAGHLADVNCTRFHPNSNY-VATGSADRTVRLWDVLNGNC-VRIFT 666

Query: 573 GHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYI 631
           GH+  +    F  +G  + + +TD ++ LW++G    +   KGH +    +  + +G+ +
Sbjct: 667 GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEIL 726

Query: 632 ACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNV 691
           A GS +N++ L+             D +K+  D      +T++F +A     LP+    +
Sbjct: 727 ASGSMDNTVRLW-------------DAIKAFEDL-----ETDDFTTATGHINLPENSQEL 768

Query: 692 LIAANSQGTIKVLEL 706
           L+      +  V+ L
Sbjct: 769 LLGTYMTKSTPVVHL 783


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)

Query: 452 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504
           +SW+      L S+  + T+ LWD       G       ++  H      V ++L+   L
Sbjct: 148 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 207

Query: 505 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
             S +DD K+ +W T  +N+     S++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 208 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 267

Query: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
           LRN K  +  F+ H+  +   ++    E + AS  TD +L +W++ K
Sbjct: 268 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 314



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 239 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 297

Query: 505 LASGSDDAKVKLW 517
           LAS   D ++ +W
Sbjct: 298 LASSGTDRRLNVW 310


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)

Query: 452 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504
           +SW+      L S+  + T+ LWD       G       ++  H      V ++L+   L
Sbjct: 182 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 241

Query: 505 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
             S +DD K+ +W T  +N+     S++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 242 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301

Query: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
           LRN K  +  F+ H+  +   ++    E + AS  TD +L +W++ K
Sbjct: 302 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 348



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 331

Query: 505 LASGSDDAKVKLW 517
           LAS   D ++ +W
Sbjct: 332 LASSGTDRRLNVW 344


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 49/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)

Query: 452 ISWSSYHKNLLASSDYEGTVILWD-------GFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504
           +SW+      L S+  + T+ LWD       G       ++  H      V ++L+   L
Sbjct: 183 LSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESL 242

Query: 505 LASGSDDAKVKLWSTNLDNSVA---SIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
             S +DD K+ +W T  +N+     S++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 243 FGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 302

Query: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
           LRN K  +  F+ H+  +   ++    E + AS  TD +L +W++ K
Sbjct: 303 LRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSK 349



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 274 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHSFESHKDEIFQVQWSPHNETI 332

Query: 505 LASGSDDAKVKLW 517
           LAS   D ++ +W
Sbjct: 333 LASSGTDRRLNVW 345


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 60/191 (31%), Positives = 93/191 (48%), Gaps = 13/191 (6%)

Query: 456 SYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVK 515
           S H NLLAS+  + TV LW      +   ++ H     SVDF+  D + LA+ S+D  +K
Sbjct: 69  SPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIK 127

Query: 516 LWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCA-DHCVHYYDLRNTKQPIMVFKG 573
           +WS      + S+    + V C KFSP  R  L   C+ D  +  +D  N KQ +  F  
Sbjct: 128 VWSMYRQRFLYSLYRHTHWVRCAKFSPDGR--LIVSCSEDKTIKIWDTTN-KQCVNNFS- 183

Query: 574 HRKAVSYAKFV----SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
              +V +A FV    SG  I SA +D  +K+W+V     L+ ++ H    N +    +G+
Sbjct: 184 --DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241

Query: 630 YIACGSENNSL 640
           Y+   S + +L
Sbjct: 242 YLITASSDGTL 252



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 64/248 (25%), Positives = 109/248 (43%), Gaps = 24/248 (9%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           LA++ ++  ++LW+     R+  Y  H+    SV F+     LLAS S D  V+LW  + 
Sbjct: 33  LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS-PHGNLLASASRDRTVRLWIPDK 91

Query: 522 DNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 580
               +  +A  A V  V FS   ++ LA    D  +  + +   +    +++ H   V  
Sbjct: 92  RGKFSEFKAHTAPVRSVDFSADGQF-LATASEDKSIKVWSMYRQRFLYSLYR-HTHWVRC 149

Query: 581 AKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNS 639
           AKF   G  IVS S D  +K+W+     C+ +F   +   NFV    +G  IA    + +
Sbjct: 150 AKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQT 209

Query: 640 LYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQG 699
           + ++   ++K L  ++  +                     C    P G  N LI A+S G
Sbjct: 210 VKVWDVRVNKLLQHYQVHS-----------------GGVNCISFHPSG--NYLITASSDG 250

Query: 700 TIKVLELV 707
           T+K+L+L+
Sbjct: 251 TLKILDLL 258



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 17/227 (7%)

Query: 400 VSSIEFDRDCDYFAIAGVTKKIKVYE-YDTVIQDAVDIHYPENEMTCNSKISCISWSSYH 458
           V S++F  D  + A A   K IKV+  Y      ++  H           + C  +S   
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRH--------THWVRCAKFSP-D 155

Query: 459 KNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWS 518
             L+ S   + T+ +WD    Q    + +       VDFN     + ++GSD   VK+W 
Sbjct: 156 GRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQT-VKVWD 214

Query: 519 TNLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKA 577
             ++  +   +     V C+ F PS  Y L    +D  +   DL   +  I   +GH   
Sbjct: 215 VRVNKLLQHYQVHSGGVNCISFHPSGNY-LITASSDGTLKILDLLEGRL-IYTLQGHTGP 272

Query: 578 VSYAKFVSGEEI-VSASTDSQLKLW--NVGKPYCLRSFKGHINEKNF 621
           V    F  G E+  S   D+Q+ LW  N  + +C    K ++   +F
Sbjct: 273 VFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHF 319



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 9/106 (8%)

Query: 564 TKQPIM--VFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFK--GHINE 618
           T+ P++   FKGH+ A++      +G+++ +AS D+ L LWN  KP+  R+++  GH + 
Sbjct: 5   TEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNF-KPHA-RAYRYVGHKDV 62

Query: 619 KNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT--VKSV 662
              V  + +G+ +A  S + ++ L+          FK  T  V+SV
Sbjct: 63  VTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSV 108


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 49/167 (29%), Positives = 80/167 (47%), Gaps = 13/167 (7%)

Query: 452 ISWSSYHKNLLASSDYEGTVILWDGFTGQRS-------KVYQEHEKRCWSVDFNLMDPKL 504
           +SW+S     L S+  + TV LWD   G +         ++  H      V ++L+   L
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241

Query: 505 LASGSDDAKVKLWSTNLDNSVAS---IEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYD 560
             S +DD K+ +W T  + +      ++A  A V C+ F+P S + LA G AD  V  +D
Sbjct: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWD 301

Query: 561 LRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSAS--TDSQLKLWNVGK 605
           LRN K  +  F+ H+  +    +    E + AS  TD +L +W++ K
Sbjct: 302 LRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSK 348



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 18/73 (24%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKV--YQEHEKRCWSVDFNLMDPKL 504
           ++++C+S++ Y + +LA+   + TV LWD     + K+  ++ H+   + V ++  +  +
Sbjct: 273 AEVNCLSFNPYSEFILATGSADKTVALWD-LRNLKLKLHTFESHKDEIFQVHWSPHNETI 331

Query: 505 LASGSDDAKVKLW 517
           LAS   D ++ +W
Sbjct: 332 LASSGTDRRLNVW 344


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 53/184 (28%), Positives = 86/184 (46%), Gaps = 5/184 (2%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           L S   + ++  WD  +   + +YQ H    W +D +       ASGS D   +LWS + 
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS-LYFASGSHDRTARLWSFDR 415

Query: 522 DNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAV-S 579
              +       A+V CVKF P+S Y LA G  D  V  +  +     + +F GHR  V S
Sbjct: 416 TYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSAQQGNS-VRLFTGHRGPVLS 473

Query: 580 YAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNS 639
            A   +G+ + SA  D +LKLW++      +  +GH +    +  + +   IA  S +NS
Sbjct: 474 LAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNS 533

Query: 640 LYLY 643
           + ++
Sbjct: 534 VRVW 537



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 43/158 (27%), Positives = 70/158 (44%), Gaps = 5/158 (3%)

Query: 463 ASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLD 522
           AS  ++ T  LW        ++Y  H      V F+  +   LA+GS D  V+LWS    
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH-PNSNYLATGSTDKTVRLWSAQQG 458

Query: 523 NSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYA 581
           NSV      +  V  + FSP+ +Y LA    D  +  +DL +        +GH   ++  
Sbjct: 459 NSVRLFTGHRGPVLSLAFSPNGKY-LASAGEDQRLKLWDLASGTL-YKELRGHTDNITSL 516

Query: 582 KFVSGEEIV-SASTDSQLKLWNVGKPYCLRSFKGHINE 618
            F     ++ SAS D+ +++W++   YC     G  +E
Sbjct: 517 TFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 32/117 (27%), Positives = 54/117 (46%), Gaps = 4/117 (3%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           + C+ +   + N LA+   + TV LW    G   +++  H     S+ F+  + K LAS 
Sbjct: 429 VDCVKFHP-NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFS-PNGKYLASA 486

Query: 509 SDDAKVKLWSTNLDNSVASIEAKA-NVCCVKFSPSSRYHLAFGCADHCVHYYDLRNT 564
            +D ++KLW          +     N+  + FSP S   +A    D+ V  +D+RNT
Sbjct: 487 GEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGL-IASASMDNSVRVWDIRNT 542



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 41/181 (22%), Positives = 72/181 (39%), Gaps = 44/181 (24%)

Query: 501 DPKLLASGSDDAKVKLWSTNL-----------------------------DNSVASIEAK 531
           D KLLA+G D++ +KLWS                                DN+   ++  
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKIL 338

Query: 532 ANVCCVKFSP---SSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAV------SYAK 582
              C   +S    +    L     D  + Y+DL +    ++ ++GH   V       Y+ 
Sbjct: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL-YQGHAYPVWDLDISPYSL 397

Query: 583 FVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYL 642
           +       S S D   +LW+  + Y LR + GH+ + + V    N +Y+A GS + ++ L
Sbjct: 398 Y-----FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452

Query: 643 Y 643
           +
Sbjct: 453 W 453


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 4/175 (2%)

Query: 448 KISCISWSSYH-KNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLA 506
           ++  + WS    + L+ S  ++ TV LWD   G+    ++ HE   +S  ++   P   A
Sbjct: 113 EVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFRGHESIIYSTIWSPHIPGCFA 172

Query: 507 SGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTK 565
           S S D  +++W          I A +A +    +   +   L  G  D  +  +DLRN +
Sbjct: 173 SASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVR 232

Query: 566 QPIMVFKGHRKAVSYAKF--VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINE 618
           QP+    GH  A+   KF       + S S D  ++ WN  KP  L     H  E
Sbjct: 233 QPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTE 287


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 45/199 (22%), Positives = 90/199 (45%), Gaps = 4/199 (2%)

Query: 446 NSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLL 505
           +++I  +S+++    ++  S ++ TV++WD  TG++  +   H     S  FN  D  L+
Sbjct: 219 SAEIISLSFNTSGDRIITGS-FDHTVVVWDADTGRKVNILIGHCAEISSASFN-WDCSLI 276

Query: 506 ASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTK 565
            +GS D   KLW       VA++    +         +   +A   AD     +    T+
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAA-TR 335

Query: 566 QPIMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGL 624
           + I   +GH   +S   F   G  +++ S+D   ++W+     CL+  +GH +E      
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAF 395

Query: 625 ASNGDYIACGSENNSLYLY 643
              G+ +  GS++N+  ++
Sbjct: 396 NYKGNIVITGSKDNTCRIW 414



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 53/242 (21%), Positives = 96/242 (39%), Gaps = 11/242 (4%)

Query: 464 SSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDN 523
           +  Y+ T  LWD  +G+     + H    +++ FN      +A+GS D   KLWS     
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK 168

Query: 524 SVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAK 582
              +     A + C+ F+P S   +A G  D     +D++N ++ +   +GH   +    
Sbjct: 169 CYHTFRGHTAEIVCLSFNPQSTL-VATGSMDTTAKLWDIQNGEE-VYTLRGHSAEIISLS 226

Query: 583 F-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLY 641
           F  SG+ I++ S D  + +W+      +    GH  E +      +   I  GS + +  
Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCK 286

Query: 642 LYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTI 701
           L+     K + T            D   D   ++   +   A  DG + +  AA  +   
Sbjct: 287 LWDATNGKCVATL-------TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA 339

Query: 702 KV 703
           K+
Sbjct: 340 KL 341



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 48/205 (23%), Positives = 88/205 (42%), Gaps = 5/205 (2%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           +  I++++ + + +A+  ++ T  LW   TG+    ++ H      + FN     L+A+G
Sbjct: 137 VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFN-PQSTLVATG 195

Query: 509 SDDAKVKLWSTNLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQP 567
           S D   KLW       V ++    A +  + F+ S    +  G  DH V  +D  +T + 
Sbjct: 196 SMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD-RIITGSFDHTVVVWD-ADTGRK 253

Query: 568 IMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLAS 626
           + +  GH   +S A F      I++ S D   KLW+     C+ +  GH +E        
Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDY 313

Query: 627 NGDYIACGSENNSLYLYYKGLSKTL 651
            G  IA  S + +  ++     K +
Sbjct: 314 TGKLIATASADGTARIFSAATRKCI 338



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 44/199 (22%), Positives = 85/199 (42%), Gaps = 6/199 (3%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLA 506
           ++I C+S++     L+A+   + T  LWD   G+     + H     S+ FN    +++ 
Sbjct: 178 AEIVCLSFNP-QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII- 235

Query: 507 SGSDDAKVKLWSTNLDNSV-ASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTK 565
           +GS D  V +W  +    V   I   A +    F+      L  G  D     +D  N K
Sbjct: 236 TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILT-GSMDKTCKLWDATNGK 294

Query: 566 QPIMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGL 624
             +    GH   +  + F  +G+ I +AS D   ++++     C+   +GH  E + +  
Sbjct: 295 -CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISF 353

Query: 625 ASNGDYIACGSENNSLYLY 643
              G+++  GS + +  ++
Sbjct: 354 NPQGNHLLTGSSDKTARIW 372



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 23/79 (29%), Positives = 35/79 (44%), Gaps = 1/79 (1%)

Query: 585 SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLAS-NGDYIACGSENNSLYLY 643
           SG   ++ S D   KLW+      L + +GH N    +   +  GD IA GS + +  L+
Sbjct: 103 SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162

Query: 644 YKGLSKTLLTFKFDTVKSV 662
                K   TF+  T + V
Sbjct: 163 SVETGKCYHTFRGHTAEIV 181


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 59/238 (24%), Positives = 101/238 (42%), Gaps = 46/238 (19%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           ++C+++S    +LLAS   + TV +W       S V++ H     SV F   D +   + 
Sbjct: 26  VTCVNFSP-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSFVTA 83

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSR----------------------- 544
           SDD  VK+W+T+    + S+    N V C KFSP  R                       
Sbjct: 84  SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 143

Query: 545 -------------YHLAFGCA-----DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKF-VS 585
                        +H +  C      D+ V  +D+R T + +  ++ H  AV+   F  S
Sbjct: 144 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR-THRLLQHYQLHSAAVNGLSFHPS 202

Query: 586 GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY 643
           G  +++AS+DS LK+ ++ +   L +  GH      V  +  G+Y A G  +  + ++
Sbjct: 203 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/209 (23%), Positives = 86/209 (41%), Gaps = 17/209 (8%)

Query: 397 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSS 456
           ++ V S+ F  D   F  A   K +KV+            H  +   + +  I+ +  + 
Sbjct: 65  TATVRSVHFCSDGQSFVTASDDKTVKVWA----------THRQKFLFSLSQHINWVRCAK 114

Query: 457 YHKN--LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKV 514
           +  +  L+ S+  + TV LWD  + +    Y EH      VDF+     + A+G D+  V
Sbjct: 115 FSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNT-V 173

Query: 515 KLWSTNLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKG 573
           K+W       +   +   A V  + F PS  Y L    +D  +   DL   +  +    G
Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY-LITASSDSTLKILDLMEGRL-LYTLHG 231

Query: 574 HR-KAVSYAKFVSGEEIVSASTDSQLKLW 601
           H+  A + A   +GE   S  +D Q+ +W
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVW 260



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 17/127 (13%)

Query: 400 VSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQDAVDIHYPENEMTCNSKISCISWSSY 457
           V+ ++F       A AG+   +KV++  T  ++Q     HY  +    N         S+
Sbjct: 152 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ-----HYQLHSAAVNGL-------SF 199

Query: 458 HK--NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVK 515
           H   N L ++  + T+ + D   G+       H+    +V F+    +  ASG  D +V 
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG-EYFASGGSDEQVM 258

Query: 516 LWSTNLD 522
           +W +N D
Sbjct: 259 VWKSNFD 265


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 59/238 (24%), Positives = 101/238 (42%), Gaps = 46/238 (19%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           ++C+++S    +LLAS   + TV +W       S V++ H     SV F   D +   + 
Sbjct: 64  VTCVNFSP-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSFVTA 121

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSR----------------------- 544
           SDD  VK+W+T+    + S+    N V C KFSP  R                       
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181

Query: 545 -------------YHLAFGCA-----DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKF-VS 585
                        +H +  C      D+ V  +D+R T + +  ++ H  AV+   F  S
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR-THRLLQHYQLHSAAVNGLSFHPS 240

Query: 586 GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY 643
           G  +++AS+DS LK+ ++ +   L +  GH      V  +  G+Y A G  +  + ++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 3/95 (3%)

Query: 571 FKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
           FKGHR AV+   F ++ +++ S S DS L +W++        F GH +    V  + +G 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 630 YIACGSENNSLYLYYKGLSKTLLTFKFD--TVKSV 662
            +A GS + ++ ++   +      F+    TV+SV
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 17/127 (13%)

Query: 400 VSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQDAVDIHYPENEMTCNSKISCISWSSY 457
           V+ ++F       A AG+   +KV++  T  ++Q     HY  +    N         S+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ-----HYQLHSAAVNGL-------SF 237

Query: 458 HK--NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVK 515
           H   N L ++  + T+ + D   G+       H+    +V F+    +  ASG  D +V 
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG-EYFASGGSDEQVM 296

Query: 516 LWSTNLD 522
           +W +N D
Sbjct: 297 VWKSNFD 303


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 59/238 (24%), Positives = 101/238 (42%), Gaps = 46/238 (19%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           ++C+++S    +LLAS   + TV +W       S V++ H     SV F   D +   + 
Sbjct: 64  VTCVNFSP-SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSFVTA 121

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSR----------------------- 544
           SDD  VK+W+T+    + S+    N V C KFSP  R                       
Sbjct: 122 SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181

Query: 545 -------------YHLAFGCA-----DHCVHYYDLRNTKQPIMVFKGHRKAVSYAKF-VS 585
                        +H +  C      D+ V  +D+R T + +  ++ H  AV+   F  S
Sbjct: 182 SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR-THRLLQHYQLHSAAVNGLSFHPS 240

Query: 586 GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY 643
           G  +++AS+DS LK+ ++ +   L +  GH      V  +  G+Y A G  +  + ++
Sbjct: 241 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 3/95 (3%)

Query: 571 FKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
           FKGHR AV+   F ++ +++ S S DS L +W++        F GH +    V  + +G 
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 630 YIACGSENNSLYLYYKGLSKTLLTFKFD--TVKSV 662
            +A GS + ++ ++   +      F+    TV+SV
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV 109



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 17/127 (13%)

Query: 400 VSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQDAVDIHYPENEMTCNSKISCISWSSY 457
           V+ ++F       A AG+   +KV++  T  ++Q     HY  +    N         S+
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ-----HYQLHSAAVNGL-------SF 237

Query: 458 HK--NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVK 515
           H   N L ++  + T+ + D   G+       H+    +V F+    +  ASG  D +V 
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG-EYFASGGSDEQVM 296

Query: 516 LWSTNLD 522
           +W +N D
Sbjct: 297 VWKSNFD 303


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 49/196 (25%), Positives = 86/196 (43%), Gaps = 5/196 (2%)

Query: 447 SKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLA 506
           S +S +        LLA+   +  V LW             H     SV  N  + +L+ 
Sbjct: 21  SNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE-ELIV 79

Query: 507 SGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTK 565
           +GS    +++W       + ++   KAN+C + F P   + +A G  D  +  +D+R  K
Sbjct: 80  AGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEF-VASGSQDTNIKLWDIRR-K 137

Query: 566 QPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGL 624
             +  ++GH +AV   +F   G+ + SA+ D  +KLW++     +  F GH    N V  
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197

Query: 625 ASNGDYIACGSENNSL 640
             N   +A GS + ++
Sbjct: 198 HPNEYLLASGSSDRTI 213



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 39/154 (25%), Positives = 75/154 (48%), Gaps = 4/154 (2%)

Query: 503 KLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDL 561
           +LLA+G DD +V LWS N  N + S+    + V  V+ +      +A G     +  +DL
Sbjct: 34  RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVA-GSQSGSIRVWDL 92

Query: 562 RNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKN 620
              K  +    GH+  +    F   GE + S S D+ +KLW++ +  C+  ++GH     
Sbjct: 93  EAAKI-LRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151

Query: 621 FVGLASNGDYIACGSENNSLYLYYKGLSKTLLTF 654
            +  + +G ++A  ++++++ L+     K +  F
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 20/69 (28%), Positives = 36/69 (52%)

Query: 585 SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYY 644
           SG  + +   D ++ LW++ KP C+ S  GH +    V L +  + I  GS++ S+ ++ 
Sbjct: 32  SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91

Query: 645 KGLSKTLLT 653
              +K L T
Sbjct: 92  LEAAKILRT 100



 Score = 38.1 bits (87), Expect = 0.028
 Identities = 33/106 (31%), Positives = 50/106 (47%), Gaps = 4/106 (3%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           + C+ +S   K L +++D + TV LWD   G+    +  H      V+F+  +  LLASG
Sbjct: 150 VRCLRFSPDGKWLASAAD-DHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH-PNEYLLASG 207

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCAD 553
           S D  ++ W       V+ IE +   V  V F+P     L  GC D
Sbjct: 208 SSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG-CCLYSGCQD 252


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 52/227 (22%), Positives = 94/227 (41%), Gaps = 56/227 (24%)

Query: 479 GQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCV 537
           G  +K+Y  H    W  D      +LL S S D K+ +W +   N V +I  +++ V   
Sbjct: 53  GHLAKIYAMH----WGTD-----SRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTC 103

Query: 538 KFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFK---GHRKAVSYAKFVSGEEIVSAS- 593
            ++PS  Y +A G  D+    Y+L+  +  + V +   GH   +S  +F+   +IV++S 
Sbjct: 104 AYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG 162

Query: 594 -----------------------------------------TDSQLKLWNVGKPYCLRSF 612
                                                     D+  KLW+V +  C ++F
Sbjct: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222

Query: 613 KGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTV 659
            GH ++ N +    NG+  A GS++ +  L+     + L+T+  D +
Sbjct: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNI 269



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 50/192 (26%), Positives = 82/192 (42%), Gaps = 15/192 (7%)

Query: 460 NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWST 519
           N + +S  + T  LWD  TGQ++  +  H     S+     D +L  SG+ DA  KLW  
Sbjct: 155 NQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSL-APDTRLFVSGACDASAKLWDV 213

Query: 520 N---LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHR- 575
                  +    E+  N  C  F P+     A G  D     +DLR   Q +M +     
Sbjct: 214 REGMCRQTFTGHESDINAIC--FFPNGNA-FATGSDDATCRLFDLR-ADQELMTYSHDNI 269

Query: 576 ----KAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYI 631
                +VS++K  SG  +++   D    +W+  K        GH N  + +G+  +G  +
Sbjct: 270 ICGITSVSFSK--SGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAV 327

Query: 632 ACGSENNSLYLY 643
           A GS ++ L ++
Sbjct: 328 ATGSWDSFLKIW 339


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 7/150 (4%)

Query: 460 NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAK--VKLW 517
           N  A+   +GTV +WD       ++ + H      VD++     L+ SGS D++  +K W
Sbjct: 215 NKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWH-PTKGLVVSGSKDSQQPIKFW 273

Query: 518 STNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRK 576
                 S+A++ A  N V  VK + +  + L     DH    +D+RN K+ + VF+GH+K
Sbjct: 274 DPKTGQSLATLHAHKNTVMEVKLNLNGNWLLT-ASRDHLCKLFDIRNLKEELQVFRGHKK 332

Query: 577 AVSYAKFVSGEE--IVSASTDSQLKLWNVG 604
             +   +    E    S  +D  L  W+VG
Sbjct: 333 EATAVAWHPVHEGLFASGGSDGSLLFWHVG 362



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 49/220 (22%), Positives = 89/220 (40%), Gaps = 12/220 (5%)

Query: 444 TCNSKISC----ISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNL 499
           T  +K+ C    + W+   + L+  +   G   LW+G T     + Q H+    ++ ++ 
Sbjct: 113 TSTNKVKCPVFVVRWTPEGRRLVTGAS-SGEFTLWNGLTFNFETILQAHDSPVRAMTWSH 171

Query: 500 MDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYY 559
            D  +L +      VK W +N++N       K  +    FSP+     A    D  V  +
Sbjct: 172 NDMWMLTA-DHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDN-KFATCSDDGTVRIW 229

Query: 560 DLRNTKQPIMVFKGHRKAVSYAKFVSGEE-IVSASTDS--QLKLWNVGKPYCLRSFKGHI 616
           D     +   + +GH   V    +   +  +VS S DS   +K W+      L +   H 
Sbjct: 230 DFLRCHEE-RILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHK 288

Query: 617 NEKNFVGLASNGDYIACGSENNSLYLY-YKGLSKTLLTFK 655
           N    V L  NG+++   S ++   L+  + L + L  F+
Sbjct: 289 NTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFR 328



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 2/72 (2%)

Query: 450 SCISWSSYHKNLLASSDYEGTVILWD-GFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           + ++W   H+ L AS   +G+++ W  G   +   +   HE   WS+ ++ +   +L SG
Sbjct: 335 TAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLG-HILCSG 393

Query: 509 SDDAKVKLWSTN 520
           S+D   K W+ N
Sbjct: 394 SNDHTSKFWTRN 405


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 49/183 (26%), Positives = 81/183 (44%), Gaps = 9/183 (4%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           LAS  ++  V+LWD  +GQ  ++   H     S DF+      LA+GS D+ V +W   +
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFS-PTVNCLATGSWDSTVHIWDLRM 178

Query: 522 DNSVASIEA----KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKA 577
                S +A     AN+ C+ +S S    LA G  D  +H +    T   ++  KGH   
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASGL--LASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235

Query: 578 VSYAKFVSGEE-IVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE 636
           V    F   E  + SA     +K+W+     CL + KG ++  +      +G  +  G+ 
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295

Query: 637 NNS 639
           + +
Sbjct: 296 DQT 298



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 52/208 (25%), Positives = 91/208 (43%), Gaps = 10/208 (4%)

Query: 460 NLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWST 519
           +L AS+  + TV LWD    +  +V + H++   +V F+  D + LASG  D +V LW  
Sbjct: 76  HLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS-PDSRQLASGGWDKRVMLWDV 134

Query: 520 NLDNSVASIEA-KANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPI--MVFKGHRK 576
                +  +   + ++    FSP+    LA G  D  VH +DLR     +     +GH  
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193

Query: 577 AVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE 636
            +S   + +   + S S D  + +W       L   KGH+     +  + +  ++A    
Sbjct: 194 NISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253

Query: 637 NNSLYLYYKGLSKTLLTFKFDTVKSVLD 664
           +  + ++     K L     +T+K VLD
Sbjct: 254 SRMVKVWDCNTGKCL-----ETLKGVLD 276



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 5/126 (3%)

Query: 539 FSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQ 597
           FSP  +  L  G  D CV+ ++ R+  Q +    GH   V + +F   G    SAS D  
Sbjct: 29  FSPDGQMLLT-GSEDGCVYGWETRSG-QLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86

Query: 598 LKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY--YKGLSKTLLTFK 655
           ++LW+V +  CLR  KGH      V  + +   +A G  +  + L+    G    LL   
Sbjct: 87  VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146

Query: 656 FDTVKS 661
            D+++S
Sbjct: 147 RDSIQS 152


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 54/193 (27%), Positives = 87/193 (45%), Gaps = 11/193 (5%)

Query: 456 SYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFN-----LMDPK--LLASG 508
           S +  +LA++ + G   LW           + H     ++ F+      +DPK   LAS 
Sbjct: 240 SPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299

Query: 509 SDDAKVKLWSTNLDNSVASIEAKA-NVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQP 567
           + D  VKLWS + D  VA IE     V  V + PS R+ L   C D     +DL   ++ 
Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRF-LGTTCYDRSWRLWDLE-AQEE 357

Query: 568 IMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLAS 626
           I+  +GH   V    F   G    +   D+  ++W++    C+   +GH+ E   +  + 
Sbjct: 358 ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP 417

Query: 627 NGDYIACGSENNS 639
           NG +IA GS +N+
Sbjct: 418 NGYHIATGSGDNT 430



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 18/69 (26%), Positives = 31/69 (44%), Gaps = 1/69 (1%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           ++ + +   H N L +  Y+ T  +W        K    HE +   +D +  D +L+A+ 
Sbjct: 452 VTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDIS-SDGQLIATC 510

Query: 509 SDDAKVKLW 517
           S D   KLW
Sbjct: 511 SYDRTFKLW 519


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 12/195 (6%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I+C+ +     N + S   + T+ +W   TG+  +    H    WS   + M   ++ SG
Sbjct: 266 ITCLQFCG---NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISG 319

Query: 509 SDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPI 568
           S D  +K+W+      + ++    +   V+        +  G  D  +  +D+  T Q +
Sbjct: 320 STDRTLKVWNAETGECIHTLYGHTST--VRCMHLHEKRVVSGSRDATLRVWDIE-TGQCL 376

Query: 569 MVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNG 628
            V  GH  AV   ++  G  +VS + D  +K+W+     CL + +GH N      L  +G
Sbjct: 377 HVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDG 433

Query: 629 DYIACGSENNSLYLY 643
            ++  GS + S+ ++
Sbjct: 434 IHVVSGSLDTSIRVW 448



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 56/257 (21%), Positives = 107/257 (41%), Gaps = 34/257 (13%)

Query: 454 WSSYHK-NLLASSDYEGTVILWDGFTGQRSKVYQEHEK--RCWSVDFNLMDPKLLASGSD 510
           WSS  + N++ S   + T+ +W+  TG+       H    RC       +  K + SGS 
Sbjct: 307 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-----LHEKRVVSGSR 361

Query: 511 DAKVKLWSTNLDNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIM 569
           DA +++W       +  +    A V CV++       +  G  D  V  +D   T+  + 
Sbjct: 362 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR---RVVSGAYDFMVKVWD-PETETCLH 417

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
             +GH   V   +F  G  +VS S D+ +++W+V    C+ +  GH  +    G+    +
Sbjct: 418 TLQGHTNRVYSLQF-DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDN 474

Query: 630 YIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGES 689
            +  G+ ++++ ++     + L T +                 N+  SAV          
Sbjct: 475 ILVSGNADSTVKIWDIKTGQCLQTLQ---------------GPNKHQSAVTCLQF---NK 516

Query: 690 NVLIAANSQGTIKVLEL 706
           N +I ++  GT+K+ +L
Sbjct: 517 NFVITSSDDGTVKLWDL 533



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 19/46 (41%), Positives = 23/46 (50%)

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           V KGH   V       G  IVS S D+ LK+W+     CLR+  GH
Sbjct: 257 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 302


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 12/195 (6%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I+C+ +     N + S   + T+ +W   TG+  +    H    WS   + M   ++ SG
Sbjct: 384 ITCLQFCG---NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISG 437

Query: 509 SDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPI 568
           S D  +K+W+      + ++    +   V+        +  G  D  +  +D+  T Q +
Sbjct: 438 STDRTLKVWNAETGECIHTLYGHTST--VRCMHLHEKRVVSGSRDATLRVWDIE-TGQCL 494

Query: 569 MVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNG 628
            V  GH  AV   ++  G  +VS + D  +K+W+     CL + +GH N      L  +G
Sbjct: 495 HVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDG 551

Query: 629 DYIACGSENNSLYLY 643
            ++  GS + S+ ++
Sbjct: 552 IHVVSGSLDTSIRVW 566



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 56/257 (21%), Positives = 107/257 (41%), Gaps = 34/257 (13%)

Query: 454 WSSYHK-NLLASSDYEGTVILWDGFTGQRSKVYQEHEK--RCWSVDFNLMDPKLLASGSD 510
           WSS  + N++ S   + T+ +W+  TG+       H    RC       +  K + SGS 
Sbjct: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-----LHEKRVVSGSR 479

Query: 511 DAKVKLWSTNLDNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIM 569
           DA +++W       +  +    A V CV++       +  G  D  V  +D   T+  + 
Sbjct: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR---RVVSGAYDFMVKVWD-PETETCLH 535

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
             +GH   V   +F  G  +VS S D+ +++W+V    C+ +  GH  +    G+    +
Sbjct: 536 TLQGHTNRVYSLQF-DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDN 592

Query: 630 YIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGES 689
            +  G+ ++++ ++     + L T +                 N+  SAV          
Sbjct: 593 ILVSGNADSTVKIWDIKTGQCLQTLQ---------------GPNKHQSAVTCLQF---NK 634

Query: 690 NVLIAANSQGTIKVLEL 706
           N +I ++  GT+K+ +L
Sbjct: 635 NFVITSSDDGTVKLWDL 651



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 19/46 (41%), Positives = 23/46 (50%)

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           V KGH   V       G  IVS S D+ LK+W+     CLR+  GH
Sbjct: 375 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 420


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 12/195 (6%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I+C+ +     N + S   + T+ +W   TG+  +    H    WS   + M   ++ SG
Sbjct: 304 ITCLQFCG---NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWS---SQMRDNIIISG 357

Query: 509 SDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPI 568
           S D  +K+W+      + ++    +   V+        +  G  D  +  +D+  T Q +
Sbjct: 358 STDRTLKVWNAETGECIHTLYGHTST--VRCMHLHEKRVVSGSRDATLRVWDIE-TGQCL 414

Query: 569 MVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNG 628
            V  GH  AV   ++  G  +VS + D  +K+W+     CL + +GH N      L  +G
Sbjct: 415 HVLMGHVAAVRCVQY-DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDG 471

Query: 629 DYIACGSENNSLYLY 643
            ++  GS + S+ ++
Sbjct: 472 IHVVSGSLDTSIRVW 486



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 56/257 (21%), Positives = 107/257 (41%), Gaps = 34/257 (13%)

Query: 454 WSSYHK-NLLASSDYEGTVILWDGFTGQRSKVYQEHEK--RCWSVDFNLMDPKLLASGSD 510
           WSS  + N++ S   + T+ +W+  TG+       H    RC       +  K + SGS 
Sbjct: 345 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMH-----LHEKRVVSGSR 399

Query: 511 DAKVKLWSTNLDNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIM 569
           DA +++W       +  +    A V CV++       +  G  D  V  +D   T+  + 
Sbjct: 400 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGR---RVVSGAYDFMVKVWD-PETETCLH 455

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGD 629
             +GH   V   +F  G  +VS S D+ +++W+V    C+ +  GH  +    G+    +
Sbjct: 456 TLQGHTNRVYSLQF-DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDN 512

Query: 630 YIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGES 689
            +  G+ ++++ ++     + L T +                 N+  SAV          
Sbjct: 513 ILVSGNADSTVKIWDIKTGQCLQTLQ---------------GPNKHQSAVTCLQF---NK 554

Query: 690 NVLIAANSQGTIKVLEL 706
           N +I ++  GT+K+ +L
Sbjct: 555 NFVITSSDDGTVKLWDL 571



 Score = 36.6 bits (83), Expect = 0.082
 Identities = 19/46 (41%), Positives = 23/46 (50%)

Query: 570 VFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           V KGH   V       G  IVS S D+ LK+W+     CLR+  GH
Sbjct: 295 VLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 340


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 64/271 (23%), Positives = 106/271 (39%), Gaps = 40/271 (14%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I  + W+    N + S+  + T I+WD  TG+  + +  H      VD+   +    AS 
Sbjct: 279 IFALKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNMTFASC 335

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADH------------C 555
           S D  + +     D+ V + +   N V  +K+ PS    L   C+D             C
Sbjct: 336 STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGM--LLASCSDDMTLKIWSMKQDAC 393

Query: 556 VHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           VH  DL+   + I   K      + +   S   + SAS DS ++LW+V +  C  +   H
Sbjct: 394 VH--DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451

Query: 616 INEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEF 675
                 V  + +G Y+A GS +   Y++        L   +     + +           
Sbjct: 452 QEPVYSVAFSPDGKYLASGSFDK--YVHIWNTQSGSLVHSYQGTGGIFE----------- 498

Query: 676 VSAVCWRALPDGESNVLIAANSQGTIKVLEL 706
              VCW A  D       A+ S G++ VL+L
Sbjct: 499 ---VCWNARGDKVG----ASASDGSVCVLDL 522



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 52/245 (21%)

Query: 481 RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS 540
           ++ V + HE   +   +N +   LLASGS D+  ++W+ N +++  S +     C  +  
Sbjct: 171 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 541 ---PSSR-----------YHLAFGCADHCVHYY--------DLRNTKQPIMVFKGHRKAV 578
              PS++             LA G  D     +         L   K PI   K ++K  
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK-- 287

Query: 579 SYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENN 638
                  G  ++SA  D    +W+       + F  H      V   +N  + +C S + 
Sbjct: 288 -------GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASC-STDM 339

Query: 639 SLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQ 698
            +++   G    + TF              +  TNE V+A+ W    D    +L + +  
Sbjct: 340 CIHVCRLGCDHPVKTF--------------QGHTNE-VNAIKW----DPSGMLLASCSDD 380

Query: 699 GTIKV 703
            T+K+
Sbjct: 381 MTLKI 385


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 64/271 (23%), Positives = 106/271 (39%), Gaps = 40/271 (14%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I  + W+    N + S+  + T I+WD  TG+  + +  H      VD+   +    AS 
Sbjct: 279 IFALKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNMTFASC 335

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADH------------C 555
           S D  + +     D+ V + +   N V  +K+ PS    L   C+D             C
Sbjct: 336 STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGM--LLASCSDDMTLKIWSMKQDAC 393

Query: 556 VHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           VH  DL+   + I   K      + +   S   + SAS DS ++LW+V +  C  +   H
Sbjct: 394 VH--DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451

Query: 616 INEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEF 675
                 V  + +G Y+A GS +   Y++        L   +     + +           
Sbjct: 452 QEPVYSVAFSPDGKYLASGSFDK--YVHIWNTQSGSLVHSYQGTGGIFE----------- 498

Query: 676 VSAVCWRALPDGESNVLIAANSQGTIKVLEL 706
              VCW A  D       A+ S G++ VL+L
Sbjct: 499 ---VCWNARGDKVG----ASASDGSVCVLDL 522



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 52/245 (21%)

Query: 481 RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS 540
           ++ V + HE   +   +N +   LLASGS D+  ++W+ N +++  S +     C  +  
Sbjct: 171 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 541 ---PSSR-----------YHLAFGCADHCVHYY--------DLRNTKQPIMVFKGHRKAV 578
              PS++             LA G  D     +         L   K PI   K ++K  
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK-- 287

Query: 579 SYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENN 638
                  G  ++SA  D    +W+       + F  H      V   +N  + +C S + 
Sbjct: 288 -------GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASC-STDM 339

Query: 639 SLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQ 698
            +++   G    + TF              +  TNE V+A+ W    D    +L + +  
Sbjct: 340 CIHVCRLGCDHPVKTF--------------QGHTNE-VNAIKW----DPSGMLLASCSDD 380

Query: 699 GTIKV 703
            T+K+
Sbjct: 381 MTLKI 385


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 64/271 (23%), Positives = 106/271 (39%), Gaps = 40/271 (14%)

Query: 449 ISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASG 508
           I  + W+    N + S+  + T I+WD  TG+  + +  H      VD+   +    AS 
Sbjct: 279 IFALKWNK-KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ--NNMTFASC 335

Query: 509 SDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYHLAFGCADH------------C 555
           S D  + +     D+ V + +   N V  +K+ PS    L   C+D             C
Sbjct: 336 STDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGM--LLASCSDDMTLKIWSMKQDAC 393

Query: 556 VHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGH 615
           VH  DL+   + I   K      + +   S   + SAS DS ++LW+V +  C  +   H
Sbjct: 394 VH--DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKH 451

Query: 616 INEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEF 675
                 V  + +G Y+A GS +   Y++        L   +     + +           
Sbjct: 452 QEPVYSVAFSPDGKYLASGSFDK--YVHIWNTQSGSLVHSYQGTGGIFE----------- 498

Query: 676 VSAVCWRALPDGESNVLIAANSQGTIKVLEL 706
              VCW A  D       A+ S G++ VL+L
Sbjct: 499 ---VCWNARGDKVG----ASASDGSVCVLDL 522



 Score = 30.4 bits (67), Expect = 5.9
 Identities = 51/245 (20%), Positives = 92/245 (37%), Gaps = 52/245 (21%)

Query: 481 RSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFS 540
           ++ V + HE   +   +N +   LLASGS D+  ++W+ N +++  S +     C  +  
Sbjct: 171 KATVLRGHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGG 229

Query: 541 ---PSSR-----------YHLAFGCADHCVHYY--------DLRNTKQPIMVFKGHRKAV 578
              PS++             LA G  D     +         L   K PI   K ++K  
Sbjct: 230 HDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKK-- 287

Query: 579 SYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENN 638
                  G  ++SA  D    +W+       + F  H      V   +N  + +C S + 
Sbjct: 288 -------GNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASC-STDM 339

Query: 639 SLYLYYKGLSKTLLTFKFDTVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQ 698
            +++   G    + TF              +  TNE V+A+ W    D    +L + +  
Sbjct: 340 CIHVCRLGCDHPVKTF--------------QGHTNE-VNAIKW----DPSGMLLASCSDD 380

Query: 699 GTIKV 703
            T+K+
Sbjct: 381 MTLKI 385


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 52/227 (22%), Positives = 92/227 (40%), Gaps = 56/227 (24%)

Query: 479 GQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCV 537
           G  +K+Y  H    W  D      +LL S S D K+ +W +   N + +I  +++ V   
Sbjct: 53  GHLAKIYAMH----WGYD-----SRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTC 103

Query: 538 KFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFK---GHRKAVSYAKFVSGEEIVSAS- 593
            ++PS  Y +A G  D+    Y+L+  +  + V +   GH   +S  +F+   +IV++S 
Sbjct: 104 AYAPSGNY-VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG 162

Query: 594 -----------------------------------------TDSQLKLWNVGKPYCLRSF 612
                                                     D+  KLW++    C +SF
Sbjct: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF 222

Query: 613 KGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTV 659
            GH+++ N V    NG   A GS++ +  L+     + LL +  D +
Sbjct: 223 TGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNI 269



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 45/187 (24%), Positives = 79/187 (42%), Gaps = 9/187 (4%)

Query: 462 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNL 521
           + +S  + T  LWD  T Q++  +  H     S+  +  D +   SG+ DA  KLW    
Sbjct: 157 IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLS-PDMRTFVSGACDASSKLWDIRD 215

Query: 522 DNSVASIEAK-ANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAV-- 578
                S     +++  V F P+  Y  A G  D     +DLR  ++  ++   H   +  
Sbjct: 216 GMCRQSFTGHVSDINAVSFFPNG-YAFATGSDDATCRLFDLRADQE--LLLYSHDNIICG 272

Query: 579 --SYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSE 636
             S A   SG  +++   D    +W+  K        GH N  + +G+  +G  +A GS 
Sbjct: 273 ITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSW 332

Query: 637 NNSLYLY 643
           ++ L ++
Sbjct: 333 DSFLRIW 339


>gi|5902034 periodic tryptophan protein 1 [Homo sapiens]
          Length = 501

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 57/222 (25%), Positives = 95/222 (42%), Gaps = 32/222 (14%)

Query: 406 DRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISC-------------- 451
           D   +Y A+  +T  I+V++ D V  D++     E   T  SK+S               
Sbjct: 202 DSTGNYIAVGNMTPVIEVWDLDIV--DSL-----EPVFTLGSKLSKKKKKKGKKSSSAEG 254

Query: 452 -------ISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKL 504
                  +SW+   +N+LAS+  + TVILWD   G+ +     H  +  ++ F+  + + 
Sbjct: 255 HTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQT 314

Query: 505 LASGSDDAKVKLWS-TNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRN 563
           L SGS D  V L+   + D S         +  V ++  S  H      D  V+  D R+
Sbjct: 315 LISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARS 374

Query: 564 TKQPIMVFKGHRKAVSYAKFVSGEE--IVSASTDSQLKLWNV 603
            K PI     H   +S     S  +  +V+AS D  +K+W++
Sbjct: 375 DK-PIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDI 415


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,251,725
Number of Sequences: 37866
Number of extensions: 1302163
Number of successful extensions: 12856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 412
Number of HSP's successfully gapped in prelim test: 557
Number of HSP's that attempted gapping in prelim test: 8761
Number of HSP's gapped (non-prelim): 3198
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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