Search of human proteins with 4885377

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885377 histone cluster 1, H1d [Homo sapiens]
         (221 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885377 histone cluster 1, H1d [Homo sapiens]                      422   e-118
gi|4885379 histone cluster 1, H1e [Homo sapiens]                      352   2e-97
gi|4885375 histone cluster 1, H1c [Homo sapiens]                      326   1e-89
gi|4885381 histone cluster 1, H1b [Homo sapiens]                      311   2e-85
gi|4885373 histone cluster 1, H1a [Homo sapiens]                      255   2e-68
gi|20544168 histone cluster 1, H1t [Homo sapiens]                     165   2e-41
gi|4885371 H1 histone family, member 0 [Homo sapiens]                 108   3e-24
gi|5174449 H1 histone family, member X [Homo sapiens]                  94   9e-20
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     67   1e-11
gi|24475863 H1 histone family, member O, oocyte-specific [Homo s...    66   3e-11
gi|32401437 H1 histone family, member N, testis-specific [Homo s...    62   5e-10
gi|111548666 SNF2 histone linker PHD RING helicase isoform a [Ho...    60   1e-09
gi|27436873 SNF2 histone linker PHD RING helicase isoform b [Hom...    60   1e-09
gi|153945728 microtubule-associated protein 1B [Homo sapiens]          56   2e-08
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo...    55   4e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    50   2e-06
gi|56676330 HP1-BP74 [Homo sapiens]                                    49   3e-06
gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s...    48   6e-06
gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s...    48   6e-06
gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ...    48   6e-06
gi|29244924 chromodomain helicase DNA binding protein 6 [Homo sa...    48   6e-06
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]            46   2e-05
gi|239754599 PREDICTED: hypothetical protein [Homo sapiens]            46   3e-05
gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo ...    45   5e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    45   5e-05
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    45   5e-05
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    45   5e-05
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    45   5e-05
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    45   5e-05
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    45   5e-05

>gi|4885377 histone cluster 1, H1d [Homo sapiens]
          Length = 221

 Score =  422 bits (1085), Expect = e-118
 Identities = 221/221 (100%), Positives = 221/221 (100%)

Query: 1   MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL 60
           MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL
Sbjct: 1   MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL 60

Query: 61  AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK 120
           AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK
Sbjct: 61  AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK 120

Query: 121 AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT 180
           AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT
Sbjct: 121 AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT 180

Query: 181 PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
           PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK
Sbjct: 181 PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221


>gi|4885379 histone cluster 1, H1e [Homo sapiens]
          Length = 219

 Score =  352 bits (902), Expect = 2e-97
 Identities = 190/221 (85%), Positives = 195/221 (88%), Gaps = 2/221 (0%)

Query: 1   MSETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSL 60
           MSETAP AP  PAPAEKTPVKKKA+K+ A A KRKASGPPVSELITKAVAASKERSGVSL
Sbjct: 1   MSETAPAAPAAPAPAEKTPVKKKARKS-AGAAKRKASGPPVSELITKAVAASKERSGVSL 59

Query: 61  AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPK 120
           AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE KPK
Sbjct: 60  AALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPK 119

Query: 121 AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT 180
           AKKAGAAK +KPAGAAKKPKK  GAATPKKS KKTPKK KKPA AAG KK AKS KK K 
Sbjct: 120 AKKAGAAKAKKPAGAAKKPKKATGAATPKKSAKKTPKKAKKPAAAAGAKK-AKSPKKAKA 178

Query: 181 PQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
            +PKKA KSPAKAKA KPKAAKPK+ KPK  K KKAA KKK
Sbjct: 179 AKPKKAPKSPAKAKAVKPKAAKPKTAKPKAAKPKKAAAKKK 219


>gi|4885375 histone cluster 1, H1c [Homo sapiens]
          Length = 213

 Score =  326 bits (835), Expect = 1e-89
 Identities = 180/222 (81%), Positives = 183/222 (82%), Gaps = 10/222 (4%)

Query: 1   MSETAPLAPTIPAPAEKTPVKKKA-KKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           MSETAP AP    PAEK PVKKKA KKAG T   RKASGPPVSELITKAVAASKERSGVS
Sbjct: 1   MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTP--RKASGPPVSELITKAVAASKERSGVS 58

Query: 60  LAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKP 119
           LAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE KP
Sbjct: 59  LAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKP 118

Query: 120 KAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVK 179
           K KKAG  KP+KP GAAKKPKK AG ATPKKS KKTPKK KKPA A  TKKVAKS KK K
Sbjct: 119 KVKKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAK 178

Query: 180 TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
             +PKKAAKS A       KA KPK+ KPKV K KKAAPKKK
Sbjct: 179 VAKPKKAAKSAA-------KAVKPKAAKPKVVKPKKAAPKKK 213


>gi|4885381 histone cluster 1, H1b [Homo sapiens]
          Length = 226

 Score =  311 bits (798), Expect = 2e-85
 Identities = 179/230 (77%), Positives = 188/230 (81%), Gaps = 13/230 (5%)

Query: 1   MSETAPLAPTIPAPAEKTPVKKKAKK--AGATAGKRKASGPPVSELITKAVAASKERSGV 58
           MSETAP     PAP EK+P KKKA K  AGA A KRKA+GPPVSELITKAVAASKER+G+
Sbjct: 1   MSETAPAETATPAPVEKSPAKKKATKKAAGAGAAKRKATGPPVSELITKAVAASKERNGL 60

Query: 59  SLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGK 118
           SLAALKKALAA GYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE K
Sbjct: 61  SLAALKKALAAGGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAK 120

Query: 119 PKAKKAGAAKPRKPAGAA-KKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKK 177
           PKAKKAGAAK +KPAGA  KK KK AGA   KK++KKTPKK KKPA AAG KKVAKS KK
Sbjct: 121 PKAKKAGAAKAKKPAGATPKKAKKAAGA---KKAVKKTPKKAKKPA-AAGVKKVAKSPKK 176

Query: 178 VK-TPQPKKAAKSPA-----KAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
            K   +PKKA KSPA     K KA KPKAAKPK+ KPK  KAKKAA KKK
Sbjct: 177 AKAAAKPKKATKSPAKPKAVKPKAAKPKAAKPKAAKPKAAKAKKAAAKKK 226


>gi|4885373 histone cluster 1, H1a [Homo sapiens]
          Length = 215

 Score =  255 bits (651), Expect = 2e-68
 Identities = 151/223 (67%), Positives = 166/223 (74%), Gaps = 10/223 (4%)

Query: 1   MSETAPLAPTIPAPAEKTPVKKKAKKAG--ATAGKRKASGPPVSELITKAVAASKERSGV 58
           MSET P AP   A  EK    KKAKK    A A K+K +GP VSELI +A ++SKER GV
Sbjct: 1   MSETVPPAPAASAAPEKPLAGKKAKKPAKAAAASKKKPAGPSVSELIVQAASSSKERGGV 60

Query: 59  SLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGK 118
           SLAALKKALAAAGYDVEKNNSRIKLG+KSLVSKGTLVQTKGTGASGSFKLNKKA+S E K
Sbjct: 61  SLAALKKALAAAGYDVEKNNSRIKLGIKSLVSKGTLVQTKGTGASGSFKLNKKASSVETK 120

Query: 119 PKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV 178
           P A K   A   K  GA+KK KK  GA+  KKS+ KTPKK KKP   A T+K +K+ KK 
Sbjct: 121 PGASK--VATKTKATGASKKLKKATGAS--KKSV-KTPKKAKKP---AATRKSSKNPKKP 172

Query: 179 KTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
           KT +PKK AKSPAKAKA KPKAAK +  KPK  K KKAAPKKK
Sbjct: 173 KTVKPKKVAKSPAKAKAVKPKAAKARVTKPKTAKPKKAAPKKK 215


>gi|20544168 histone cluster 1, H1t [Homo sapiens]
          Length = 207

 Score =  165 bits (418), Expect = 2e-41
 Identities = 107/220 (48%), Positives = 134/220 (60%), Gaps = 18/220 (8%)

Query: 1   MSETAPLAPTIPAPA--EKTPVKKKAKK-AGATAGKRKASGPPVSELITKAVAASKERSG 57
           MSET P A      A  EK P KK+ +K AG  +  RK     VS+LIT+A++ S+ER G
Sbjct: 1   MSETVPAASASAGVAAMEKLPTKKRGRKPAGLISASRKVPNLSVSKLITEALSVSQERVG 60

Query: 58  VSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEG 117
           +SL ALKKALAAAGYDVEKNNSRIKL LKSLV+KG LVQT+GTGASGSFKL+KK      
Sbjct: 61  MSLVALKKALAAAGYDVEKNNSRIKLSLKSLVNKGILVQTRGTGASGSFKLSKKVIPKST 120

Query: 118 KPKAKKAGAAKPRK--PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSA 175
           + KAKK+ +AK +K   +  +K PK             KT K+ KKP   A T K  +S 
Sbjct: 121 RSKAKKSVSAKTKKLVLSRDSKSPKTA-----------KTNKRAKKP--RATTPKTVRSG 167

Query: 176 KKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKK 215
           +K K  + K+  KSP KA+A K K  +      +   +KK
Sbjct: 168 RKAKGAKGKQQQKSPVKARASKSKLTQHHEVNVRKATSKK 207


>gi|4885371 H1 histone family, member 0 [Homo sapiens]
          Length = 194

 Score =  108 bits (271), Expect = 3e-24
 Identities = 81/205 (39%), Positives = 104/205 (50%), Gaps = 28/205 (13%)

Query: 24  AKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKL 83
           AK   A A K+    P  S++I  A+ A K R+G S  +++K + +     E  +S+IKL
Sbjct: 11  AKPKRAKASKKSTDHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKL 70

Query: 84  GLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVA 143
            +K LV+ G L QTKG GASGSF+L K               + +P+K     K  K++ 
Sbjct: 71  SIKRLVTTGVLKQTKGVGASGSFRLAK---------------SDEPKKSVAFKKTKKEIK 115

Query: 144 GAATPKKSIKKTPKKVKKPATAAGTKKV----AKSAKKVKTPQPKKAAKSPAKAKAPKPK 199
             ATPKK+      K KK A+ A TKK      K AKK     PKKA K P   KA   K
Sbjct: 116 KVATPKKA-----SKPKKAASKAPTKKPKATPVKKAKKKLAATPKKA-KKPKTVKAKPVK 169

Query: 200 AAKPKSGKPKVTKAK---KAAPKKK 221
           A+KPK  KP   KAK   K A KKK
Sbjct: 170 ASKPKKAKPVKPKAKSSAKRAGKKK 194


>gi|5174449 H1 histone family, member X [Homo sapiens]
          Length = 213

 Score = 94.0 bits (232), Expect = 9e-20
 Identities = 73/219 (33%), Positives = 102/219 (46%), Gaps = 20/219 (9%)

Query: 7   LAPTIPAPAEKTPVKKKAKKAGATA---------GKRKASGPPVSELITKAVAASKERSG 57
           L   +P    +   KK  K  G+ A          K+K      S+L+ + +    ER+G
Sbjct: 5   LEEALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNG 64

Query: 58  VSLAAL-KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE 116
            SLA +  +A     +D +   + +K  +K+LV   TL+Q KGTGA+GSFKLN+K   G 
Sbjct: 65  SSLAKIYTEAKKVPWFDQQNGRTYLKYSIKALVQNDTLLQVKGTGANGSFKLNRKKLEGG 124

Query: 117 GKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAK 176
           G+ +   A A     PA  A K KK A  A   +   K P + +KP     + K    AK
Sbjct: 125 GERRGAPAAAT---APAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQR--SHKKGAGAK 179

Query: 177 KVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKK 215
           K K  + KK A +  K      KAAKP    PKV K +K
Sbjct: 180 KDKGGKAKKTAAAGGK---KVKKAAKP--SVPKVPKGRK 213



 Score = 30.8 bits (68), Expect = 0.96
 Identities = 26/74 (35%), Positives = 32/74 (43%), Gaps = 6/74 (8%)

Query: 5   APLAPTIPAPAEKTPVKKKAKKAGA-TAGKRKASG-PPVSELITKAVAASKERSGVSLAA 62
           AP A T PAP      K     AG+  A K+ A G  P      K   A K++ G +   
Sbjct: 130 APAAATAPAPTAHKAKKAAPGAAGSRRADKKPARGQKPEQRSHKKGAGAKKDKGGKA--- 186

Query: 63  LKKALAAAGYDVEK 76
            KK  AA G  V+K
Sbjct: 187 -KKTAAAGGKKVKK 199


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 69/209 (33%), Positives = 97/209 (46%), Gaps = 20/209 (9%)

Query: 14  PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
           P  K+P K++AK         KA  P   E  + A A S E++   +    K+ A A   
Sbjct: 562 PEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA--- 618

Query: 74  VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPA 133
                S +K   KS     +  + K      + K  +KA S E K +AK    AK    A
Sbjct: 619 ----KSPVKEEAKSPAEVKSPEKAKSPTKEEA-KSPEKAKSPE-KEEAKSPEKAKSPVKA 672

Query: 134 GAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKA 193
             AK P+K   A +P K+  K+P+K K P      K+ AKS +K K+P  K+ AKSP KA
Sbjct: 673 -EAKSPEK---AKSPVKAEAKSPEKAKSPV-----KEEAKSPEKAKSPV-KEEAKSPEKA 722

Query: 194 KAP-KPKAAKPKSGKPKVTKAKKAAPKKK 221
           K+P K +A  P+  K  V +  K+  K K
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAK 751



 Score = 65.5 bits (158), Expect = 3e-11
 Identities = 64/224 (28%), Positives = 99/224 (44%), Gaps = 24/224 (10%)

Query: 13  APAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGY 72
           A  E+   ++  ++  A  G+ +   PP  E      AAS E+   S    +    A   
Sbjct: 478 AKEEEGKEEEGGEEEEAEGGEEETKSPPAEE------AASPEKEAKSPVKEEAKSPAEAK 531

Query: 73  DVEKNNSRIKLGLKSLVSKGTLVQTKGTG---ASGSFKLNKKAASGEGKPKAKKAGAAKP 129
             EK  ++    +KS     +  + +      A    K   K+ +    P+  K+ A + 
Sbjct: 532 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591

Query: 130 RKPAGAAKKPKKV-----------AGAATPKKSIKKTPKKVKKPATAAG-TKKVAKSAKK 177
            K    AK P+K            A A +P K   K+P +VK P  A   TK+ AKS +K
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK 651

Query: 178 VKTPQPKKAAKSPAKAKAP-KPKAAKPKSGKPKVTKAKKAAPKK 220
            K+P+ K+ AKSP KAK+P K +A  P+  K  V KA+  +P+K
Sbjct: 652 AKSPE-KEEAKSPEKAKSPVKAEAKSPEKAKSPV-KAEAKSPEK 693



 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 67/232 (28%), Positives = 101/232 (43%), Gaps = 22/232 (9%)

Query: 5   APLAPTIPAPAE-KTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKER----SGVS 59
           +P+     +PAE K+P K++AK         KA  P   E  +   A S E+    S   
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE 577

Query: 60  LAALKKALAAAGYDV---------EKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNK 110
           + + +KA + A  +          EK  S +K   KS     + V+ +    +   K  +
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA-EVKSPE 636

Query: 111 KAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATA-AGTK 169
           KA S   +       A  P K    AK P+K   A +P K+  K+P+K K P  A A + 
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEE--AKSPEK---AKSPVKAEAKSPEKAKSPVKAEAKSP 691

Query: 170 KVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
           + AKS  K +   P+KA KSP K +A  P+ AK    +   T  K  +P K+
Sbjct: 692 EKAKSPVKEEAKSPEKA-KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 69/255 (27%), Positives = 108/255 (42%), Gaps = 44/255 (17%)

Query: 5   APLAPTIPAPAE-------KTPVKKKAK--KAGATAGKRKASGPPVSELITKAVAASKER 55
           +P+     +PAE       K+P K++AK  +   +  K +A  P  ++   KA A S E+
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679

Query: 56  SGVSLAALKKALAAAGYDV-------EKNNSRIKLGLKSLV-SKGTLVQTKGTGASGSFK 107
           +   + A  K+   A   V       EK  S +K   KS   +K  + +   T       
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739

Query: 108 LNKKAASGEG-------------KPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK 154
           + ++A S E               P+AK     + R PA   K P+K   A +P K   K
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD--KFPEK---AKSPVKEEVK 794

Query: 155 TPKKVKKP--ATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKA------AKPKSG 206
           +P+K K P    A   +K     ++VK+P  ++      K K P  KA      A PK+ 
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854

Query: 207 KPKVTKAKKAAPKKK 221
           + K +K K+ APKK+
Sbjct: 855 EKKDSK-KEEAPKKE 868



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 58/220 (26%), Positives = 87/220 (39%), Gaps = 22/220 (10%)

Query: 17  KTPVKKKAK--KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
           K+PVK +AK  +   +  K +A  P  ++   K  A S E++       K  +       
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA-------KSPVKEEAKTP 733

Query: 75  EKNNSRIKLGLKS-----LVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK---KAGA 126
           EK  S +K   KS        K   +  K   A    K   ++ + +   KAK   K   
Sbjct: 734 EKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEV 793

Query: 127 AKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKA 186
             P K     K+  K      PKK   K+P K ++       K+  K A++ K P   K 
Sbjct: 794 KSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKT 853

Query: 187 --AKSPAKAKAPKPKAAKPK---SGKPKVTKAKKAAPKKK 221
              K   K +APK +A KPK     +P V K K++  + K
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 45/155 (29%), Positives = 76/155 (49%), Gaps = 12/155 (7%)

Query: 76  KNNSRIKLGLKSLVSKGTLV---QTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKP 132
           K+  +IK+  KS   K T++   QT+ T  +      ++  + E + K ++ G  +  + 
Sbjct: 439 KSEEKIKVVEKS--EKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496

Query: 133 AGAAKKPKKVAGAATPKKSIKKTPK-KVKKPATA-AGTKKVAKSAKKVKTPQ-----PKK 185
                K      AA+P+K  K   K + K PA A +  K+ AKS  +VK+P+      K+
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556

Query: 186 AAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
            AKSP +AK+P+ + AK  +      KAK  A ++
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591



 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 58/219 (26%), Positives = 95/219 (43%), Gaps = 13/219 (5%)

Query: 5   APLAPTIPAPAE-KTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAAL 63
           +P+   + +P + K+P+K+ AK       K++    PV E   +     K +     A  
Sbjct: 787 SPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKE--EEKPQEVKVKEPPKKAEE 844

Query: 64  KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKK 123
           +KA A    + EK +S+ +   K    K  + + K        +   +A   E + K K 
Sbjct: 845 EKAPATPKTE-EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKK- 902

Query: 124 AGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPK--KVKKPATAAGTKKVA---KSAKKV 178
                P K A A  + K+ A      +  KK P   K K+P+  A  K+ A   K  K+ 
Sbjct: 903 --VPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEE 960

Query: 179 KTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAA 217
           K  +P++  K+ AKAK      +K  S KPK  KA+K++
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPS-KPKAEKAEKSS 998



 Score = 44.7 bits (104), Expect = 6e-05
 Identities = 59/212 (27%), Positives = 79/212 (37%), Gaps = 18/212 (8%)

Query: 12   PAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAG 71
            P   E+ P + K K+    A + KA   P +E   +   + KE +    A   K      
Sbjct: 823  PVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE---EKKDSKKEEAPKKEAPKPKVEEKKE 879

Query: 72   YDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRK 131
              VEK         K        V T    A    ++ + A     KPK K   A K   
Sbjct: 880  PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-----KPKEKTEVAKKEPD 934

Query: 132  PAGAAK--KPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKS 189
             A A +  KP +   AA  KK  K+  +K KKP     T+  AK   K  + +P K    
Sbjct: 935  DAKAKEPSKPAEKKEAAPEKKDTKE--EKAKKPEEKPKTEAKAKEDDKTLSKEPSK---- 988

Query: 190  PAKAKAPKPKAAKPKSGKP--KVTKAKKAAPK 219
            P   KA K  +   K  KP  K T+ K A  K
Sbjct: 989  PKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 64/224 (28%), Positives = 86/224 (38%), Gaps = 24/224 (10%)

Query: 17  KTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEK 76
           K+PVK++AK         KA    V     K  A  + RS       +KA +    +V K
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFP-EKAKSPVKEEV-K 794

Query: 77  NNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK-PRKPAGA 135
           +  + K  LK           K        K  +K    + K   KKA   K P  P   
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854

Query: 136 AKK-------PKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAK 188
            KK       PKK A    PK   KK P  V+KP  +    K  ++  K K P P+K A 
Sbjct: 855 EKKDSKKEEAPKKEA--PKPKVEEKKEPA-VEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911

Query: 189 SPAKAK---APKPKA----AKPKSGK----PKVTKAKKAAPKKK 221
           +  + K    PK K      +P   K     K  + K+AAP+KK
Sbjct: 912 AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955



 Score = 41.6 bits (96), Expect = 5e-04
 Identities = 52/190 (27%), Positives = 76/190 (40%), Gaps = 20/190 (10%)

Query: 3    ETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAA 62
            E AP  P       KT  KK +KK  A   K++A  P V E    AV   KE    S   
Sbjct: 845  EKAPATP-------KTEEKKDSKKEEAP--KKEAPKPKVEEKKEPAVEKPKE----SKVE 891

Query: 63   LKKALAAAGYDV----EKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGK 118
             KK  A     V    ++  +++++   +   + T V  K    + + + +K A   E  
Sbjct: 892  AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951

Query: 119  PKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV 178
            P+ K     K +KP    +KPK  A A    K++ K P K K       +    K +K  
Sbjct: 952  PEKKDTKEEKAKKPE---EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008

Query: 179  KTPQPKKAAK 188
            +     KAAK
Sbjct: 1009 EKATEDKAAK 1018



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 57/222 (25%), Positives = 88/222 (39%), Gaps = 16/222 (7%)

Query: 11  IPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELIT--KAVAASKERSGVSLAAL-KKAL 67
           + +P  KTP K++A+   A     KA  P   E+ +  KA +  KE +      + KK  
Sbjct: 761 VKSPEAKTPAKEEARSP-ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819

Query: 68  AAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAA 127
             +    E+    +K+  K    K    +   T  +   K +KK  +   K +A K    
Sbjct: 820 VKSPVKEEEKPQEVKV--KEPPKKAEEEKAPATPKTEEKKDSKKEEAP--KKEAPKPKVE 875

Query: 128 KPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV----KTPQP 183
           + ++PA    K  KV       +  KK P   K+       K+ AK  +K     K P  
Sbjct: 876 EKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD 935

Query: 184 KKAAK--SPAKAK--APKPKAAKPKSGKPKVTKAKKAAPKKK 221
            KA +   PA+ K  AP+ K  K +  K    K K  A  K+
Sbjct: 936 AKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977


>gi|24475863 H1 histone family, member O, oocyte-specific [Homo
           sapiens]
          Length = 346

 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 70/236 (29%), Positives = 104/236 (44%), Gaps = 55/236 (23%)

Query: 39  PPVSELITKAVAASKERSGVSLAALKKALAAA--GYDVEKNNSRIKLGLKSLVSKGTLVQ 96
           PPV  ++ +A+ A ++R G S+AA+K  +       DV +    +K  L + + +G L +
Sbjct: 53  PPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLAR 112

Query: 97  ---TKGTGASGSFKLNKK----------------AASGEGKPKA-KKAGAAK-------- 128
              +K  GA+GSFKL  K                  +GE K K  KK   AK        
Sbjct: 113 PLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGK 172

Query: 129 --------------PRKPAGAAKKPKKVAGAATPKKS----IKKTPKKVKK----PATAA 166
                         P KP  A +K +K  GAA   ++     +K P K  K    P++A 
Sbjct: 173 VKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAG 232

Query: 167 GTKKVAKSAKKVKTPQPKKAA--KSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
           G  + AK AK  ++ Q    A  K+ A++K+ KP A+K K+G    TK K  A  K
Sbjct: 233 GLSRKAK-AKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAK 287



 Score = 35.8 bits (81), Expect = 0.030
 Identities = 53/214 (24%), Positives = 89/214 (41%), Gaps = 41/214 (19%)

Query: 9   PTIPAPAEKTP-----VKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAAL 63
           P  P+ A++ P     VKK AK+        K   PP          A+ E++     A 
Sbjct: 157 PKKPSEAKEDPPNVGKVKKAAKRPA------KVQKPPPKP------GAATEKARKQGGAA 204

Query: 64  KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKK 123
           K   A +G +  K   +    +++  S G L  ++   A GS     +++ G+ +   K 
Sbjct: 205 KDTRAQSG-EARKVPPKPDKAMRAPSSAGGL--SRKAKAKGS-----RSSQGDAEAYRKT 256

Query: 124 AGAAKPRKPAGAAKKPKKVAGAATPKK----SIKKTPK-------KVKKPATAAGTKKV- 171
              +K  KP  +  K     GAA+P K    +  K PK       K   PA  +G+K V 
Sbjct: 257 KAESKSSKPTASKVKN----GAASPTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVP 312

Query: 172 AKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKS 205
           A  ++K + P+  + A  P KA + K  + + ++
Sbjct: 313 AHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA 346


>gi|32401437 H1 histone family, member N, testis-specific [Homo
           sapiens]
          Length = 255

 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 56/206 (27%), Positives = 103/206 (50%), Gaps = 40/206 (19%)

Query: 14  PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
           PAEKT         G  +    +S   VS+L+ +A++  K   G++LAALKK L  AGY+
Sbjct: 41  PAEKT--------VGGPSRGCSSSVLRVSQLVLQAISTHK---GLTLAALKKELRNAGYE 89

Query: 74  VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPA 133
           V + + R +       +K TL++  G+ A+G F++ K                 KPR+  
Sbjct: 90  VRRKSGRHEAPRGQ--AKATLLRVSGSDAAGYFRVWK---------------VPKPRRKP 132

Query: 134 GAAKKPKKVAGAATPKK--SIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPA 191
           G A++ +   G   P +  +  ++ ++ ++P      +K A+ A++V     +  AK+ A
Sbjct: 133 GRARQEE---GTRAPWRTPAAPRSSRRRRQP-----LRKAARKAREVWRRNAR--AKAKA 182

Query: 192 KAKAPKPKAAKPKSGKPKVTKAKKAA 217
            A+A + + A+P++ +P   +AK+ A
Sbjct: 183 NARARRTRRARPRAKEPPCARAKEEA 208


>gi|111548666 SNF2 histone linker PHD RING helicase isoform a [Homo
           sapiens]
          Length = 1687

 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 1/100 (1%)

Query: 33  KRKASGPPVSELITKAVAASKERSGVSLAALKKALAAA-GYDVEKNNSRIKLGLKSLVSK 91
           K K   PP   +I  AV     + GVS+ ++ K +++   YDV++N S +K  LK L+ +
Sbjct: 434 KEKVQCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSIYRYDVQRNRSLLKRMLKCLIFE 493

Query: 92  GTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRK 131
           G + Q KG G SG+F L K     +   K KK     PRK
Sbjct: 494 GLVKQIKGHGFSGTFTLGKNYKEEDICDKTKKQAVGSPRK 533


>gi|27436873 SNF2 histone linker PHD RING helicase isoform b [Homo
           sapiens]
          Length = 1659

 Score = 60.5 bits (145), Expect = 1e-09
 Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 1/100 (1%)

Query: 33  KRKASGPPVSELITKAVAASKERSGVSLAALKKALAAA-GYDVEKNNSRIKLGLKSLVSK 91
           K K   PP   +I  AV     + GVS+ ++ K +++   YDV++N S +K  LK L+ +
Sbjct: 434 KEKVQCPPTRVMILTAVKEMNGKKGVSILSIYKYVSSIYRYDVQRNRSLLKRMLKCLIFE 493

Query: 92  GTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRK 131
           G + Q KG G SG+F L K     +   K KK     PRK
Sbjct: 494 GLVKQIKGHGFSGTFTLGKNYKEEDICDKTKKQAVGSPRK 533


>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
          Length = 2468

 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 59/208 (28%), Positives = 86/208 (41%), Gaps = 18/208 (8%)

Query: 16  EKTPVKKKAKKAGATAGK--RKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
           EK P  +  +K      K  +  + P V+E   K V + +E S V     +K        
Sbjct: 575 EKPPKVESKEKVMVKKDKPIKTETKPSVTE---KEVPSKEEPSPVKAEVAEK-------- 623

Query: 74  VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPA 133
            +  + + K   +  V K T V+ +        K  K+ A  E K   KK    K  +  
Sbjct: 624 -QATDVKPKAAKEKTVKKETKVKPEDKKEEKE-KPKKEVAKKEDKTPIKKEEKPKKEEVK 681

Query: 134 GAAKKPKKVAGAATPKKSIKKT--PKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPA 191
              KK  K      PKK +KK   PK+VKK       K+V K  K+ K  + KK  K   
Sbjct: 682 KEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKK-EIKKLPKDAK 740

Query: 192 KAKAPKPKAAKPKSGKPKVTKAKKAAPK 219
           K+  P  +A KP + KPKV K +++  K
Sbjct: 741 KSSTPLSEAKKPAALKPKVPKKEESVKK 768



 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 62/209 (29%), Positives = 84/209 (40%), Gaps = 26/209 (12%)

Query: 11  IPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASK--ERSGVSLAALKKALA 68
           +P+  E +PVK +  +  AT  K KA+     +  TK     K  E+        KK   
Sbjct: 607 VPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDK 666

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
                ++K     K  +K  V K    + K        K  KK    E  PK  K    K
Sbjct: 667 TP---IKKEEKPKKEEVKKEVKKEIKKEEK--------KEPKKEVKKETPPKEVKKEVKK 715

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAK 188
             K     KK +K      PKK IKK PK  KK +T     K   +A K K P+ +++ K
Sbjct: 716 EEKKE--VKKEEK-----EPKKEIKKLPKDAKKSSTPLSEAK-KPAALKPKVPKKEESVK 767

Query: 189 SPAKAKAPKPKAAKPKSGKPKVTKAKKAA 217
             + A A KPK    + GK KV K +  A
Sbjct: 768 KDSVA-AGKPK----EKGKIKVIKKEGKA 791



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 61/215 (28%), Positives = 91/215 (42%), Gaps = 21/215 (9%)

Query: 18  TPVKKKAKKAGATAGKRKASGPPVSELITKAVAA-SKERSG----VSLAALKKALAAAGY 72
           TPV K+ K     A  R++  P    L +K+V   SKE +     V+       + +   
Sbjct: 527 TPVVKQTKLK-QRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEK 585

Query: 73  DVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKA------KKAGA 126
            + K +  IK   K  V++   V +K   +    ++ +K A+ + KPKA      KK   
Sbjct: 586 VMVKKDKPIKTETKPSVTEKE-VPSKEEPSPVKAEVAEKQAT-DVKPKAAKEKTVKKETK 643

Query: 127 AKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKA 186
            KP       +KPKK       KK  K   KK +KP      K+V K  KK +  +PKK 
Sbjct: 644 VKPEDKKEEKEKPKKEVA----KKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKE 699

Query: 187 AKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
            K   K   PK    + K  + K  K ++  PKK+
Sbjct: 700 VK---KETPPKEVKKEVKKEEKKEVKKEEKEPKKE 731



 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 43/134 (32%), Positives = 61/134 (45%), Gaps = 16/134 (11%)

Query: 85   LKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAG 144
            LK  + + T  +  GT    S  + K  + G+ KP A     A P KPAG  +   KV+ 
Sbjct: 2235 LKKDLKEKTKTKKPGTKTKSSSPVKK--SDGKSKPLA-----ASP-KPAGLKESSDKVSR 2286

Query: 145  AATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPK 204
             A+PKK  K++ +K  KP T   T +V  +  + K  + K AA + A   A   K A   
Sbjct: 2287 VASPKK--KESVEKAAKPTT---TPEVKAARGEEKDKETKNAANASASKSA---KTATAG 2338

Query: 205  SGKPKVTKAKKAAP 218
             G  K TK+    P
Sbjct: 2339 PGTTKTTKSSAVPP 2352



 Score = 35.8 bits (81), Expect = 0.030
 Identities = 31/96 (32%), Positives = 41/96 (42%), Gaps = 17/96 (17%)

Query: 129  PRKPAGAAKKPKKVAGAATPKKSIKKTPK---KVKKPATAAGTKKVAKSAKKVKTPQPKK 185
            PR P  +   P+ +A      K++KK  K   K KKP T            K  +P  K 
Sbjct: 2212 PRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKT----------KSSSPVKKS 2261

Query: 186  AAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
              KS   A +PKP   K  S K     ++ A+PKKK
Sbjct: 2262 DGKSKPLAASPKPAGLKESSDK----VSRVASPKKK 2293



 Score = 33.9 bits (76), Expect = 0.11
 Identities = 45/212 (21%), Positives = 77/212 (36%), Gaps = 19/212 (8%)

Query: 17   KTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASK-ERSGVSLAALKKALAAAGY--D 73
            ++P ++K+ K G+          PVSE+ + ++   K E      A +K+         D
Sbjct: 1426 ESPFEEKSGKQGSPD-----QVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDD 1480

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPA 133
            VE  +S+  L L                  GSFK + K +  EG    K A         
Sbjct: 1481 VEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAE 1540

Query: 134  GAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAK----------SAKKVKTPQP 183
                  + VA  +T   +    P+      + +   +V            S   V+TP  
Sbjct: 1541 DTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTT 1600

Query: 184  -KKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK 214
             ++   SP+K + P+P +  P    PK  K++
Sbjct: 1601 FQETEMSPSKEECPRPMSISPPDFSPKTAKSR 1632



 Score = 32.0 bits (71), Expect = 0.43
 Identities = 31/119 (26%), Positives = 45/119 (37%), Gaps = 23/119 (19%)

Query: 18   TPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAA----LKKALAAAGYD 73
            +PVKK   K+   A   K +G   S      VA+ K++  V  AA      +  AA G +
Sbjct: 2256 SPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEE 2315

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKP 132
             +K                   +TK    + + K  K A +G G  K  K+ A  P  P
Sbjct: 2316 KDK-------------------ETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLP 2355



 Score = 30.0 bits (66), Expect = 1.6
 Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 4/52 (7%)

Query: 2    SETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASG----PPVSELITKAV 49
            S++  L+P+ P+P EKTP+ +++     T  + K S      PVS  +T+ V
Sbjct: 1254 SKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEV 1305



 Score = 29.3 bits (64), Expect = 2.8
 Identities = 20/54 (37%), Positives = 23/54 (42%), Gaps = 5/54 (9%)

Query: 120 KAKKAGAAKPRKPAGAAKKPKKVAGAATPK-----KSIKKTPKKVKKPATAAGT 168
           +AKK  A KP+ P       K    A  PK     K IKK  K  +  A A GT
Sbjct: 748 EAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGT 801



 Score = 28.9 bits (63), Expect = 3.6
 Identities = 19/75 (25%), Positives = 27/75 (36%)

Query: 146 ATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKS 205
           AT K    + P  V K           +S K    P P K+ +  +K + P+        
Sbjct: 516 ATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVE 575

Query: 206 GKPKVTKAKKAAPKK 220
             PKV   +K   KK
Sbjct: 576 KPPKVESKEKVMVKK 590


>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
           sapiens]
          Length = 1158

 Score = 55.5 bits (132), Expect = 4e-08
 Identities = 43/105 (40%), Positives = 55/105 (52%), Gaps = 11/105 (10%)

Query: 110 KKAASGEGKPKAKKAGAAK--PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAG 167
           +KA +G GKP  +   AA+  P K     KK KK  G   PK+S++ +P+  KK     G
Sbjct: 67  RKAQAG-GKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKK-----G 120

Query: 168 TKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTK 212
            +K  K+ KK K  +P KA K P K K PK    KPK   PK TK
Sbjct: 121 KEKPPKATKKPK-EKPPKATKKP-KEKPPK-ATKKPKEKPPKATK 162



 Score = 42.0 bits (97), Expect = 4e-04
 Identities = 37/103 (35%), Positives = 43/103 (41%), Gaps = 23/103 (22%)

Query: 96  QTKGTGASGSFKLNKKAA--SGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIK 153
           +TK  G  G      K    S EG P+  K G  KP K   A KKPK            +
Sbjct: 89  KTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPK---ATKKPK------------E 133

Query: 154 KTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAP 196
           K PK  KKP      +K  K+ KK K  +P KA K P   K P
Sbjct: 134 KPPKATKKP-----KEKPPKATKKPK-EKPPKATKKPPSGKRP 170


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 63/245 (25%), Positives = 93/245 (37%), Gaps = 48/245 (19%)

Query: 19  PVKKKAKKAGATAGKRKAS-------GPPVSELITKAVAASKERSGVSLA-ALKKALAAA 70
           PV KKAKK  +++    +S       GPP      K  A   +R G+    A  KA  ++
Sbjct: 73  PVAKKAKKKASSSDSEDSSEEEEEVQGPPA-----KKAAVPAKRVGLPPGKAAAKASESS 127

Query: 71  GYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGA----SGSFKLNKKAASGEGKPKAKK--- 123
             +   ++   +   K  V KG   Q K   A    + S   +  ++S +  PK +K   
Sbjct: 128 SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKI 187

Query: 124 ------AGAAKPRKPAGAAKK---------------------PKKVAGAATPKKSIKKTP 156
                 A    P KPA AA K                      ++   AATPKK++ K  
Sbjct: 188 TPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQ 247

Query: 157 KKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
              K P  AA T     S+ +  +   ++  K P K K P P ++ P    P   K+   
Sbjct: 248 VVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNK-PGPYSSVPPPSAPPPKKSLGT 306

Query: 217 APKKK 221
            P KK
Sbjct: 307 QPPKK 311



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 57/218 (26%), Positives = 94/218 (43%), Gaps = 9/218 (4%)

Query: 8   APTIPAPAEKTPVKKKAKKAGATAGKRKASGP-PVS---ELITKAVAASKERSGVSLAAL 63
           AP+ PA   K    K A    + A K  A+   PV    +L+T+   +S      S +  
Sbjct: 376 APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEE 435

Query: 64  KKALAAAGYDVEKNNSRIKLGLKSLVS-KGTLVQTKGTGASGSFKLNKKAASGEGKPKAK 122
           +K          K  ++  L L +  + +G+   +  + +S S +  +K +    K K +
Sbjct: 436 EKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQ 495

Query: 123 K-AGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTP 181
           K AG A P KPA A K   + + +++   S ++  +K+K   +       A     + T 
Sbjct: 496 KVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSAL-TA 554

Query: 182 QPKKAAKSPAKAKAPKPKAA--KPKSGKPKVTKAKKAA 217
           Q  KAAK+  + +  K KAA    KSG  K  K  +AA
Sbjct: 555 QNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAA 592



 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 58/247 (23%), Positives = 92/247 (37%), Gaps = 54/247 (21%)

Query: 15  AEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
           +E  P K +  K      K +   PP       A AA K  +G + ++   + +++  D 
Sbjct: 175 SEDEPPKNQKPKITPVTVKAQTKAPP-----KPARAAPKIANGKAASSSSSSSSSSSSDD 229

Query: 75  EKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRK--- 131
            +         K++  K  + +     A+      +K++S E     ++    KP K   
Sbjct: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTP---TRKSSSSEDSSSDEEEEQKKPMKNKP 286

Query: 132 ------PAGAAKKPKKVAGAATPKKSIKK----------------TPKKVKKPATAAGTK 169
                 P  +A  PKK  G   PKK+++K                + ++ KKP T A   
Sbjct: 287 GPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVS 346

Query: 170 KVAKSAKKVKTPQPKKAAKSPAKA---------KAPKPKA--AKPKSGKPKVTKAK---- 214
           K        K P  KKAA+S + +         +AP   A   K  S KP VT       
Sbjct: 347 KAT-----TKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVK 401

Query: 215 -KAAPKK 220
             AAPK+
Sbjct: 402 PAAAPKQ 408


>gi|56676330 HP1-BP74 [Homo sapiens]
          Length = 553

 Score = 48.9 bits (115), Expect = 3e-06
 Identities = 26/87 (29%), Positives = 50/87 (57%), Gaps = 2/87 (2%)

Query: 39  PPVSELITKAVAASKERSGVSLAALKKALAAA--GYDVEKNNSRIKLGLKSLVSKGTLVQ 96
           P +  ++T+A+ A  ++SG S+ A++K +       ++E+    +K  LK  +++G + Q
Sbjct: 159 PKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQ 218

Query: 97  TKGTGASGSFKLNKKAASGEGKPKAKK 123
            KG GASGSF + +K+     K + +K
Sbjct: 219 VKGKGASGSFVVVQKSRKTPQKSRNRK 245



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 53/199 (26%), Positives = 79/199 (39%), Gaps = 21/199 (10%)

Query: 25  KKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSR--IK 82
           KK+G    K    G  +   I  A+AA  E    S  ALKK +         N     +K
Sbjct: 329 KKSGE---KPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLK 385

Query: 83  LGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKV 142
             L+     G + Q  G G SG+F+L          P     G   P+K    ++   + 
Sbjct: 386 KTLQKCEKNGWMEQISGKGFSGTFQLCF--------PYYPSPGVLFPKKEPDDSRDEDED 437

Query: 143 AGAATPKKSIKKTP---KKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPK 199
              ++ + S  + P   ++++K   A    K A   ++   P PK +A    KA+ P PK
Sbjct: 438 EDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKAR-PLPK 496

Query: 200 AAKPKSGKPKVTKAKKAAP 218
            A PK+  P    AKK  P
Sbjct: 497 KAPPKAKTP----AKKTRP 511



 Score = 30.4 bits (67), Expect = 1.2
 Identities = 28/104 (26%), Positives = 49/104 (47%), Gaps = 6/104 (5%)

Query: 15  AEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAA--AGY 72
           + KTP K + +K  ++A   +     + +++  A     E    S + ++K ++      
Sbjct: 234 SRKTPQKSRNRKNRSSAVDPEPQ-VKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKL 292

Query: 73  DVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGE 116
            V+     +K  L+  V +G L Q  G GASG+F+L K   SGE
Sbjct: 293 RVDIRPQLLKNALQRAVERGQLEQITGKGASGTFQLKK---SGE 333


>gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo
            sapiens]
          Length = 2971

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 33/83 (39%), Positives = 38/83 (45%), Gaps = 3/83 (3%)

Query: 131  KPAGAAKKPKK-VAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKS 189
            KPA A   P K VA      K     P    KPATAA  K VA     V+ P    A   
Sbjct: 2700 KPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAA--KPVAAKPAAVRPPAAAAAKPV 2757

Query: 190  PAKAKAPKPKAAKPKSGKPKVTK 212
              K + P+P+AAKP + KP  TK
Sbjct: 2758 ATKPEVPRPQAAKPAATKPATTK 2780



 Score = 31.6 bits (70), Expect = 0.56
 Identities = 32/104 (30%), Positives = 36/104 (34%), Gaps = 23/104 (22%)

Query: 139  PKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV---KTPQPKKAAKSPAKAK- 194
            P  V  + T        P    KP T   TK V  + K V     P  K AA  PA AK 
Sbjct: 2653 PNNVTSSPTSNPVTTTKPVTTTKPVTTT-TKPVTTTTKPVTIINQPSVKPAAAKPAPAKP 2711

Query: 195  -APKP-----------------KAAKPKSGKPKVTKAKKAAPKK 220
             A KP                  AAKP + KP   +   AA  K
Sbjct: 2712 VAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPAAAAAK 2755


>gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo
            sapiens]
          Length = 3177

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 33/83 (39%), Positives = 38/83 (45%), Gaps = 3/83 (3%)

Query: 131  KPAGAAKKPKK-VAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKS 189
            KPA A   P K VA      K     P    KPATAA  K VA     V+ P    A   
Sbjct: 2906 KPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAA--KPVAAKPAAVRPPAAAAAKPV 2963

Query: 190  PAKAKAPKPKAAKPKSGKPKVTK 212
              K + P+P+AAKP + KP  TK
Sbjct: 2964 ATKPEVPRPQAAKPAATKPATTK 2986



 Score = 31.6 bits (70), Expect = 0.56
 Identities = 32/104 (30%), Positives = 36/104 (34%), Gaps = 23/104 (22%)

Query: 139  PKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV---KTPQPKKAAKSPAKAK- 194
            P  V  + T        P    KP T   TK V  + K V     P  K AA  PA AK 
Sbjct: 2859 PNNVTSSPTSNPVTTTKPVTTTKPVTTT-TKPVTTTTKPVTIINQPSVKPAAAKPAPAKP 2917

Query: 195  -APKP-----------------KAAKPKSGKPKVTKAKKAAPKK 220
             A KP                  AAKP + KP   +   AA  K
Sbjct: 2918 VAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPAAAAAK 2961


>gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo
            sapiens]
          Length = 2570

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 33/83 (39%), Positives = 38/83 (45%), Gaps = 3/83 (3%)

Query: 131  KPAGAAKKPKK-VAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKS 189
            KPA A   P K VA      K     P    KPATAA  K VA     V+ P    A   
Sbjct: 2299 KPAAAKPAPAKPVAAKPVATKMATVRPPVAVKPATAA--KPVAAKPAAVRPPAAAAAKPV 2356

Query: 190  PAKAKAPKPKAAKPKSGKPKVTK 212
              K + P+P+AAKP + KP  TK
Sbjct: 2357 ATKPEVPRPQAAKPAATKPATTK 2379



 Score = 31.6 bits (70), Expect = 0.56
 Identities = 32/104 (30%), Positives = 36/104 (34%), Gaps = 23/104 (22%)

Query: 139  PKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV---KTPQPKKAAKSPAKAK- 194
            P  V  + T        P    KP T   TK V  + K V     P  K AA  PA AK 
Sbjct: 2252 PNNVTSSPTSNPVTTTKPVTTTKPVTTT-TKPVTTTTKPVTIINQPSVKPAAAKPAPAKP 2310

Query: 195  -APKP-----------------KAAKPKSGKPKVTKAKKAAPKK 220
             A KP                  AAKP + KP   +   AA  K
Sbjct: 2311 VAAKPVATKMATVRPPVAVKPATAAKPVAAKPAAVRPPAAAAAK 2354


>gi|29244924 chromodomain helicase DNA binding protein 6 [Homo
           sapiens]
          Length = 2715

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 38/125 (30%), Positives = 55/125 (44%), Gaps = 14/125 (11%)

Query: 95  VQTKGTGASGSFKLNKKAASGEGK----------PKAKKAGAAKPRKPAGAAKKPKKVAG 144
           ++  G G +G  K  KK   G+ +          PK K+    K  K    AK+PKK   
Sbjct: 82  MEDSGGGGTGVKKKRKKKEPGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKE 141

Query: 145 AATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPK 204
              PK+  K   KK +KP  A+GTK+ AK  +       +  ++  +K + P P   K K
Sbjct: 142 HKEPKQ--KDGAKKARKPREASGTKE-AKEKRSCTDSAARTKSRKASKEQGPTP-VEKKK 197

Query: 205 SGKPK 209
            GK K
Sbjct: 198 KGKRK 202



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 33/117 (28%), Positives = 46/117 (39%), Gaps = 12/117 (10%)

Query: 113 ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVA 172
           + G G    KK    +P    GAAK  K       PK   K+ PK+ K+P  A   KK  
Sbjct: 85  SGGGGTGVKKKRKKKEPGDQEGAAKGSKD----REPKPKRKREPKEPKEPRKAKEPKKAK 140

Query: 173 K--------SAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
           +         AKK + P+     K   + ++    AA+ KS K    +      KKK
Sbjct: 141 EHKEPKQKDGAKKARKPREASGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKK 197


>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 819

 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 56/229 (24%), Positives = 86/229 (37%), Gaps = 35/229 (15%)

Query: 22  KKAKKAGATAGKRKASGPPVSELIT---KAVAASKERSGVSLAALKKALAAAGYDVEKNN 78
           ++ K A   A  R+  G    +      KA    K R G S     K L   G +     
Sbjct: 226 RRPKPAAGGAKSRRGGGKKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAG 285

Query: 79  SRIKLGLKSLVSKGTLVQTKGTGASGSFKL---NKKAASGEGKP-----KAKKAGAAKPR 130
           ++     +   + G     KG G  G   L   N +   G  KP     KA KA AA  +
Sbjct: 286 AK----RRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341

Query: 131 KPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTK--------------KVAKSAK 176
           +  G  +K   V G  + KK  ++  K  ++ A+AAG K              +     K
Sbjct: 342 RGGGGQQKAA-VVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDKKGLREAKRRGDGRK 400

Query: 177 KVKTPQPKKAAKSPAKAK-----APKPKAAKPKSGKPKVTKAKKAAPKK 220
           K +   P++ A+    AK     + KP+   PK+ K +  K++    KK
Sbjct: 401 KPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK 449



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 47/182 (25%), Positives = 68/182 (37%), Gaps = 19/182 (10%)

Query: 46  TKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGS 105
           TKA AA  +R G           AA   V+    + + G K    K +    K  G    
Sbjct: 333 TKAAAAGTKRGGGGQQK------AAVVGVKSRKKQRRRGKKPRRQKASAAGAKSRGGGDK 386

Query: 106 FKLNKKAASGEGKPK---------AKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP 156
             L +    G+G+ K         A+KA AAKPR   G +KKP++    A   +  K   
Sbjct: 387 KGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPR--GGGSKKPRRRGPKAAKSRGGKSRS 444

Query: 157 KKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAA--KPKSGKPKVTKAK 214
              KKP       +   +    ++   KK  +  A A   K +    K  SGK    + +
Sbjct: 445 GGGKKPRRRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQ 504

Query: 215 KA 216
           KA
Sbjct: 505 KA 506



 Score = 42.0 bits (97), Expect = 4e-04
 Identities = 59/230 (25%), Positives = 89/230 (38%), Gaps = 36/230 (15%)

Query: 8   APTIPAPAEKTPV----KKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAAL 63
           AP + A A    +     KK ++  A AG +KA          K   A KE    +    
Sbjct: 39  APALSAAAAGVKILGSGDKKLRRQKAAAGGKKARLRG-----QKGAVAGKE----ARQHW 89

Query: 64  KKALAAAGYDVEKNNSR--IKLGLKSLVSKGTLVQTKG--TGASGS----FKLNKKAASG 115
           +KA  A G +      +     G KSL  +G   + +G    A+GS    ++  K AA+G
Sbjct: 90  QKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAATGSKKPRWRAQKSAAAG 149

Query: 116 EGKPKAKKAGAAKPRKPAGA----AKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKV 171
               K + AGA K    AG      +KP+K A A    +S KK  ++        G K  
Sbjct: 150 S---KNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKSRSGKKPRRR--------GAKSR 198

Query: 172 AKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
               KK +  + K         +  K +  KP +G  K  +     P+K+
Sbjct: 199 GDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQKQ 248



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 50/206 (24%), Positives = 85/206 (41%), Gaps = 27/206 (13%)

Query: 31  AGKRKASGPPVSELITKA---VAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLKS 87
           A  R   G P+   + +    +AA      +S AA    +  +G D +    +   G K 
Sbjct: 12  AAGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSG-DKKLRRQKAAAGGK- 69

Query: 88  LVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK-----KAGAAKPRKPAGAAKKPKKV 142
              K  L   KG  A    + + + A+G G  + +     KA AA  +   G  +KP++ 
Sbjct: 70  ---KARLRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRR 126

Query: 143 AGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT---------PQPKKAAKSPAKA 193
              A    S  K P+   + + AAG+K     A+K             +P+KAA + AK+
Sbjct: 127 GQKAAATGS--KKPRWRAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGEKPQKAAAAGAKS 184

Query: 194 ---KAPKPKAAKPKSGKPKVTKAKKA 216
              K P+ + AK +  + K  + ++A
Sbjct: 185 RSGKKPRRRGAKSRGDEDKKGRQREA 210



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 55/208 (26%), Positives = 85/208 (40%), Gaps = 31/208 (14%)

Query: 22  KKAKKAG--ATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNS 79
           +KA+ AG  ATA   K+ G         AVA +K R G S +  ++   AAG        
Sbjct: 504 QKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRVGGSKSRQRQKAVAAG-------- 555

Query: 80  RIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAAS------GEGKPKAKKAGAAKPRKPA 133
                  +    G   Q++G G +   +  + AA+      G+ +P  +KA A   +  +
Sbjct: 556 ------ATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKAAAGVTKSRS 609

Query: 134 G-AAKKPKKVAGAATPKKSIKKTPKKVKKPATAA------GTKKVAKSAKKVKTPQPKKA 186
           G   KK  +   A T  KS KK  ++ +K A AA      G        K+ +  +P  A
Sbjct: 610 GDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAA 669

Query: 187 AKSPAKAKAPKPKAAKPKSGKPKVTKAK 214
               + A A   +A   K  KP+  +AK
Sbjct: 670 GSESSAAAAVGQEAEARK--KPRRRRAK 695



 Score = 39.3 bits (90), Expect = 0.003
 Identities = 51/213 (23%), Positives = 77/213 (36%), Gaps = 15/213 (7%)

Query: 17  KTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEK 76
           K P ++ AK  G    K +          T+     K R     A   K+    G   +K
Sbjct: 188 KKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGGKKPQK 247

Query: 77  NNSR---IKLGLKSLVSKGT-----LVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
              R      G KS V K        ++ +G  A+ +    + AA+   KP AK  G   
Sbjct: 248 QRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKGRGGRG 307

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAK 188
           P+   G  + P+   G   P++  +K  K     A AAGTK+     +K      K   K
Sbjct: 308 PKSLGG--QNPRWGRGGKKPRRRGQKATK-----AAAAGTKRGGGGQQKAAVVGVKSRKK 360

Query: 189 SPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKKK 221
              + K P+ + A     K +    KK   + K
Sbjct: 361 QRRRGKKPRRQKASAAGAKSRGGGDKKGLREAK 393



 Score = 33.9 bits (76), Expect = 0.11
 Identities = 58/222 (26%), Positives = 80/222 (36%), Gaps = 38/222 (17%)

Query: 17  KTPVKKKAK-KAGATAGKR---KASGPPVSELITK---AVAASKERSGVSLAALKKALAA 69
           K P K++ + +  AT GK    K+ G    +L  +   A  A  +R G + A  K A   
Sbjct: 243 KKPQKQRRRGQKAATGGKSRVGKSRGGGDKKLRRQGQNAALAGAKRRGAATAGEKPAAKG 302

Query: 70  AGYDVEKN----NSRIKLGLKSLVSKG---TLVQTKGTGASGS---------FKLNKKAA 113
            G    K+    N R   G K    +G   T     GT   G           K  KK  
Sbjct: 303 RGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQR 362

Query: 114 SGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAK 173
               KP+ +KA AA  +   G  KK  + A         K+     KKP      ++  K
Sbjct: 363 RRGKKPRRQKASAAGAKSRGGGDKKGLREA---------KRRGDGRKKPRWQNPRRRAQK 413

Query: 174 SAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKK 215
           +      P  K       K +   PKAAK + GK +    KK
Sbjct: 414 A------PAAKPRGGGSKKPRRRGPKAAKSRGGKSRSGGGKK 449



 Score = 30.8 bits (68), Expect = 0.96
 Identities = 37/138 (26%), Positives = 54/138 (39%), Gaps = 15/138 (10%)

Query: 13  APAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGY 72
           A A K P +++AK  G   G+  A G    +   K     K R G      K   +    
Sbjct: 683 AEARKKPRRRRAKSRG-DGGQNAAVGINPWQRRGKKPRLGKSRGG---GGAKSRGSGGAK 738

Query: 73  DVEKNNSRIKLGLKSLVSK----GTLVQTKGTGA---SGSFKLN----KKAASGEGKPKA 121
                 ++ + G K+  SK    G   + +G GA   SG   +     K AA+G  KP  
Sbjct: 739 SRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKAAAAGGKKPPR 798

Query: 122 KKAGAAKPRKPAGAAKKP 139
            K+   + +K A   KKP
Sbjct: 799 VKSRGGRGQKAAAGGKKP 816



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 35/124 (28%), Positives = 48/124 (38%), Gaps = 26/124 (20%)

Query: 124 AGAAKPRKPAGAA--KKPKKVAG---------AATPKKSIKKTPKKVKKPATAAGTKKV- 171
           AG A P  P GAA  + P ++A          AA   K +    KK+++   AAG KK  
Sbjct: 13  AGRAGPGAPLGAALARTPVELAAESAAPALSAAAAGVKILGSGDKKLRRQKAAAGGKKAR 72

Query: 172 ------AKSAKKVKTPQPKKAAKSPA--------KAKAPKPKAAKPKSGKPKVTKAKKAA 217
                 A + K+ +    K A    A        KA A   K+   +  KP+    K AA
Sbjct: 73  LRGQKGAVAGKEARQHWQKAAGAGGAENRGGGEQKAAAAGTKSLGGRGRKPRRRGQKAAA 132

Query: 218 PKKK 221
              K
Sbjct: 133 TGSK 136


>gi|239754599 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 294

 Score = 45.8 bits (107), Expect = 3e-05
 Identities = 33/102 (32%), Positives = 49/102 (48%), Gaps = 9/102 (8%)

Query: 115 GEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIK--------KTPKKVKKPATAA 166
           G  KP+ +KA AA+ +   G  KKP++   AA  +K+          K P++  + A  A
Sbjct: 141 GSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRGGGKKPRRGGQKAVGA 200

Query: 167 GTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKP 208
           G KK  K+A    T  P++  +  AKA     KAA  +S  P
Sbjct: 201 GAKKPQKAA-AAGTKTPRRRRQKAAKAAVWGQKAAAGESLTP 241



 Score = 44.7 bits (104), Expect = 6e-05
 Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 14/112 (12%)

Query: 111 KAASG--EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
           +A SG    +P+++  G+ KPR+   AA + K + G         K P++ K    AAG 
Sbjct: 125 RAGSGVCRSRPQSRGGGSRKPRRQKAAAAQAKSLGGGG-------KKPRRQK--CAAAGQ 175

Query: 169 KKVAKSAKKVKTPQPKKAAKSPAKAKAPKPK---AAKPKSGKPKVTKAKKAA 217
           K  A+ +++    +P++  +    A A KP+   AA  K+ + +  KA KAA
Sbjct: 176 KAAAEESRRGGGKKPRRGGQKAVGAGAKKPQKAAAAGTKTPRRRRQKAAKAA 227



 Score = 39.7 bits (91), Expect = 0.002
 Identities = 48/175 (27%), Positives = 67/175 (38%), Gaps = 21/175 (12%)

Query: 15  AEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
           A+  P++  A +AG+    R    PP  E  T +          S A        +G   
Sbjct: 80  AQCRPMQATAAEAGSPGLGRLGKEPPSRESWTGSAPRRCPCQDASRAG-------SGVCR 132

Query: 75  EKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKA---KKAGAAKPR- 130
            +  SR     K    K    Q K  G  G     +K A+   K  A   ++ G  KPR 
Sbjct: 133 SRPQSRGGGSRKPRRQKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRGGGKKPRR 192

Query: 131 ---KPAGA-AKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTP 181
              K  GA AKKP+K A A T      KTP++ ++ A  A       +A +  TP
Sbjct: 193 GGQKAVGAGAKKPQKAAAAGT------KTPRRRRQKAAKAAVWGQKAAAGESLTP 241



 Score = 30.4 bits (67), Expect = 1.2
 Identities = 28/120 (23%), Positives = 47/120 (39%), Gaps = 5/120 (4%)

Query: 101 GASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVK 160
           G+ G  +L K+  S E        G+A  R P   A +       + P+     + K  +
Sbjct: 93  GSPGLGRLGKEPPSRESW-----TGSAPRRCPCQDASRAGSGVCRSRPQSRGGGSRKPRR 147

Query: 161 KPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
           + A AA  K +    KK +  +   A +  A  ++ +    KP+ G  K   A    P+K
Sbjct: 148 QKAAAAQAKSLGGGGKKPRRQKCAAAGQKAAAEESRRGGGKKPRRGGQKAVGAGAKKPQK 207


>gi|239753329 PREDICTED: hypothetical protein XP_002345623 [Homo
           sapiens]
          Length = 351

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 6/106 (5%)

Query: 115 GEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAK- 173
           G+ KP+ +   AAK R   G   + +K AGA   K    + P++  + A AAG KK+ K 
Sbjct: 141 GDKKPRRRGQKAAKSRGGGGKKPRGQKAAGAGAKKH---RKPRRRGERAAAAGGKKLQKA 197

Query: 174 SAKKVKTPQPKKAAKSPAKAKAPK--PKAAKPKSGKPKVTKAKKAA 217
           +A K +    KK A +  K    +   KAAK + G  K  + +KAA
Sbjct: 198 AAAKSRGGGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAA 243



 Score = 37.0 bits (84), Expect = 0.013
 Identities = 39/147 (26%), Positives = 65/147 (44%), Gaps = 16/147 (10%)

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
           AAG   +K+    + G ++  + G  +Q      S      K AA+G  KP+ ++ G   
Sbjct: 168 AAGAGAKKHRKPRRRGERAAAAGGKKLQKAAAAKSRGGGGKKTAAAGGKKPR-RRRGQKA 226

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKT-----PQP 183
            +   G  KK ++   A T  KS     +  KKP    G KK  +  +  K+      +P
Sbjct: 227 AKSRGGGDKKLERQKAALTGVKS-----RGDKKP--LRGGKKQRERGQNTKSRGGGGEKP 279

Query: 184 KKAAKSPAKA---KAPKPKAAKPKSGK 207
           +KAA + AK+   +  KP+ A+   G+
Sbjct: 280 QKAAAAGAKSRGGRGEKPQKAEAGQGQ 306



 Score = 36.6 bits (83), Expect = 0.017
 Identities = 42/133 (31%), Positives = 56/133 (42%), Gaps = 20/133 (15%)

Query: 96  QTKGTGASGSFKLNKKAASGEG----KPKAKKA---GAAKPRKPAGAAKKPKKVAGAATP 148
           Q +G G     +  +KAA   G    KP+ +KA   GA K RKP    ++    A AA  
Sbjct: 136 QNRGGGDKKPRRRGQKAAKSRGGGGKKPRGQKAAGAGAKKHRKPRRRGER----AAAAGG 191

Query: 149 KKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKS--PAKAKAPKPKAA----K 202
           KK  K    K +      G K  A   KK +  + +KAAKS      K  + KAA    K
Sbjct: 192 KKLQKAAAAKSRG---GGGKKTAAAGGKKPRRRRGQKAAKSRGGGDKKLERQKAALTGVK 248

Query: 203 PKSGKPKVTKAKK 215
            +  K  +   KK
Sbjct: 249 SRGDKKPLRGGKK 261


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 543 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 602

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 603 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 662

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 663 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 722

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 723 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 782



 Score = 44.3 bits (103), Expect = 8e-05
 Identities = 58/254 (22%), Positives = 95/254 (37%), Gaps = 53/254 (20%)

Query: 17  KTPVKKKAKKAGATAGK--RKASGPPVSELI--------------TKAVAASKERSGVSL 60
           K   K + +KAG T       A+G  V+ L+              T  V+ ++E   V  
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 61  --AALKKALAAAGY----------DVEKNNSRIKLGLKSLVSKGTLVQTKGT-------- 100
             AA K  + +AG             ++ +  +K   K L  +      KGT        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPA 241

Query: 101 --GASGSFKLNKKA---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPK 149
             G +G+     KA         +S E     ++  AAK    A A+ K  +V  A+ P 
Sbjct: 242 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 301

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPK 209
           K   ++P+K   PA    T      A+  K  +  +++   + ++   P  AKP    P+
Sbjct: 302 K---ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQ 358

Query: 210 VTKAK---KAAPKK 220
           V  A    K +P+K
Sbjct: 359 VRAASAPAKESPRK 372



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 41/157 (26%), Positives = 57/157 (36%), Gaps = 25/157 (15%)

Query: 14   PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
            PA +TP  KK KK GA  G   +  P  +   +K  A   + SG               D
Sbjct: 1278 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG---------------D 1322

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK--KAGAAKPRK 131
            V++   +  LG +    +      KG G              +  PK+K  K  + K +K
Sbjct: 1323 VKEKKGKGSLGSQGAKDEPEEELQKGMGTV--------EGGDQSNPKSKKEKKKSDKRKK 1374

Query: 132  PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
                 +K KK   A+T         KK KK  TA  T
Sbjct: 1375 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1411



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 28/125 (22%), Positives = 48/125 (38%), Gaps = 18/125 (14%)

Query: 113 ASGEGKPKAKKAGAAKP--------RKPAGAAKKPKKVAGAATPKK----------SIKK 154
           + GE       A   KP        R PAG A  P +   A+TP+K          S  +
Sbjct: 864 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 923

Query: 155 TPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK 214
           +  +   PAT   T  +  +   + T  P+ A K+     +   ++++   GK +   A 
Sbjct: 924 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 983

Query: 215 KAAPK 219
           + + K
Sbjct: 984 QVSKK 988



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 270

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 271 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 304

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 305 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 362

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 363 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 396



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 116  EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK-----TPKKVKKPATAAGTKK 170
            +  P      AAK         KP++ AG  +PK   K+     TP+K +KP   AG  +
Sbjct: 1150 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1209

Query: 171  VAKSAKKVKTP-----QPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
             +  A +         QP    ++  +A   K      +  + KV    K + +K
Sbjct: 1210 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264



 Score = 29.6 bits (65), Expect = 2.1
 Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 17/217 (7%)

Query: 16   EKTPVKKKAKKAGATAGKRKASGP-PVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
            E  P +     +  T GK  ASG  P      K  A + + S ++L +        G   
Sbjct: 1170 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS-NITQCLLGQPW 1228

Query: 75   EKNNSRIKLGLKSLVS------KGTLVQTKGTGASGSFKLNKKAASGEGK----PKAKKA 124
              N ++++  +  +++      +  +V T    +   ++  K+  SG+      P++KK 
Sbjct: 1229 PLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKK 1288

Query: 125  GAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP-----KKVKKPATAAGTKKVAKSAKKVK 179
                  +   A+  P+K +  +  K    K       KK K    + G K   +   +  
Sbjct: 1289 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1348

Query: 180  TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
                +   +S  K+K  K K+ K K  K K  K KKA
Sbjct: 1349 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1385



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 531 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 590

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 591 KAGTATSPAGSSPAVAGGTQRPAEDS 616


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 43/241 (17%)

Query: 2   SETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLA 61
           ++ +P     PAP +   V  + K  GA    ++A  P      ++  + S+E       
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVK-GGALPPAKRAKKPEEESESSEEGSESEEE------ 282

Query: 62  ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGT----------GASGSFKLNKK 111
                 A AG       S++K   K L  +      KGT          G +G+     K
Sbjct: 283 ------APAG-----TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331

Query: 112 A---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKP 162
           A         +S E     ++  AAK    A A+ K  +V  A+ P K   ++P+K   P
Sbjct: 332 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK---ESPRKGAAP 388

Query: 163 ATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK---KAAPK 219
           A    T      A+  K  +  +++   + ++   P  AKP    P+V  A    K +P+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448

Query: 220 K 220
           K
Sbjct: 449 K 449



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 41/157 (26%), Positives = 57/157 (36%), Gaps = 25/157 (15%)

Query: 14   PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
            PA +TP  KK KK GA  G   +  P  +   +K  A   + SG               D
Sbjct: 1317 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG---------------D 1361

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK--KAGAAKPRK 131
            V++   +  LG +    +      KG G              +  PK+K  K  + K +K
Sbjct: 1362 VKEKKGKGSLGSQGAKDEPEEELQKGMGTV--------EGGDQSNPKSKKEKKKSDKRKK 1413

Query: 132  PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
                 +K KK   A+T         KK KK  TA  T
Sbjct: 1414 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1450



 Score = 34.7 bits (78), Expect = 0.066
 Identities = 46/202 (22%), Positives = 74/202 (36%), Gaps = 27/202 (13%)

Query: 21  KKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSR 80
           K+KA++  A   K+     P+S   T   +  +E +    A     LA+       N+S 
Sbjct: 62  KRKAEEDAALQAKKTRVSDPIS---TSESSEEEEEAEAETAKATPRLAST------NSSV 112

Query: 81  IKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPK 140
           +   L S + +    +T+  G +G    N       GK  A       PRK A  +    
Sbjct: 113 LGADLPSSMKEKAKAETEKAGKTG----NSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168

Query: 141 KVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAK----AKAP 196
            V+          +T ++   PA  A  K    SA +  +     ++ S         + 
Sbjct: 169 LVS----------ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSV 218

Query: 197 KPKAAKPKSGKPKVTKAKKAAP 218
           KP   K  S   K + A+KAAP
Sbjct: 219 KPAQVKASSVSTKESPARKAAP 240



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 347

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 348 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 381

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 382 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 439

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 116  EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK-----TPKKVKKPATAAGTKK 170
            +  P      AAK         KP++ AG  +PK   K+     TP+K +KP   AG  +
Sbjct: 1189 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248

Query: 171  VAKSAKKVKTP-----QPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
             +  A +         QP    ++  +A   K      +  + KV    K + +K
Sbjct: 1249 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1303



 Score = 30.8 bits (68), Expect = 0.96
 Identities = 26/113 (23%), Positives = 43/113 (38%), Gaps = 18/113 (15%)

Query: 113  ASGEGKPKAKKAGAAKP--------RKPAGAAKKPKKVAGAATPKK----------SIKK 154
            + GE       A   KP        R PAG A  P +   A+TP+K          S  +
Sbjct: 941  SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000

Query: 155  TPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGK 207
            +  +   PAT   T  +  +   + T  P+ A K+     +   ++++   GK
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 1053



 Score = 29.6 bits (65), Expect = 2.1
 Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 17/217 (7%)

Query: 16   EKTPVKKKAKKAGATAGKRKASGP-PVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
            E  P +     +  T GK  ASG  P      K  A + + S ++L +        G   
Sbjct: 1209 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS-NITQCLLGQPW 1267

Query: 75   EKNNSRIKLGLKSLVS------KGTLVQTKGTGASGSFKLNKKAASGEGK----PKAKKA 124
              N ++++  +  +++      +  +V T    +   ++  K+  SG+      P++KK 
Sbjct: 1268 PLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKK 1327

Query: 125  GAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP-----KKVKKPATAAGTKKVAKSAKKVK 179
                  +   A+  P+K +  +  K    K       KK K    + G K   +   +  
Sbjct: 1328 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1387

Query: 180  TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
                +   +S  K+K  K K+ K K  K K  K KKA
Sbjct: 1388 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1424



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDS 693


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 43/241 (17%)

Query: 2   SETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLA 61
           ++ +P     PAP +   V  + K  GA    ++A  P      ++  + S+E       
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVK-GGALPPAKRAKKPEEESESSEEGSESEEE------ 282

Query: 62  ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGT----------GASGSFKLNKK 111
                 A AG       S++K   K L  +      KGT          G +G+     K
Sbjct: 283 ------APAG-----TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331

Query: 112 A---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKP 162
           A         +S E     ++  AAK    A A+ K  +V  A+ P K   ++P+K   P
Sbjct: 332 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK---ESPRKGAAP 388

Query: 163 ATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK---KAAPK 219
           A    T      A+  K  +  +++   + ++   P  AKP    P+V  A    K +P+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448

Query: 220 K 220
           K
Sbjct: 449 K 449



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 41/157 (26%), Positives = 57/157 (36%), Gaps = 25/157 (15%)

Query: 14   PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
            PA +TP  KK KK GA  G   +  P  +   +K  A   + SG               D
Sbjct: 1354 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG---------------D 1398

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK--KAGAAKPRK 131
            V++   +  LG +    +      KG G              +  PK+K  K  + K +K
Sbjct: 1399 VKEKKGKGSLGSQGAKDEPEEELQKGMGTV--------EGGDQSNPKSKKEKKKSDKRKK 1450

Query: 132  PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
                 +K KK   A+T         KK KK  TA  T
Sbjct: 1451 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1487



 Score = 34.7 bits (78), Expect = 0.066
 Identities = 46/202 (22%), Positives = 74/202 (36%), Gaps = 27/202 (13%)

Query: 21  KKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSR 80
           K+KA++  A   K+     P+S   T   +  +E +    A     LA+       N+S 
Sbjct: 62  KRKAEEDAALQAKKTRVSDPIS---TSESSEEEEEAEAETAKATPRLAST------NSSV 112

Query: 81  IKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPK 140
           +   L S + +    +T+  G +G    N       GK  A       PRK A  +    
Sbjct: 113 LGADLPSSMKEKAKAETEKAGKTG----NSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168

Query: 141 KVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAK----AKAP 196
            V+          +T ++   PA  A  K    SA +  +     ++ S         + 
Sbjct: 169 LVS----------ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSV 218

Query: 197 KPKAAKPKSGKPKVTKAKKAAP 218
           KP   K  S   K + A+KAAP
Sbjct: 219 KPAQVKASSVSTKESPARKAAP 240



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 28/125 (22%), Positives = 48/125 (38%), Gaps = 18/125 (14%)

Query: 113  ASGEGKPKAKKAGAAKP--------RKPAGAAKKPKKVAGAATPKK----------SIKK 154
            + GE       A   KP        R PAG A  P +   A+TP+K          S  +
Sbjct: 941  SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000

Query: 155  TPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK 214
            +  +   PAT   T  +  +   + T  P+ A K+     +   ++++   GK +   A 
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 1060

Query: 215  KAAPK 219
            + + K
Sbjct: 1061 QVSKK 1065



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 347

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 348 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 381

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 382 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 439

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 116  EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK-----TPKKVKKPATAAGTKK 170
            +  P      AAK         KP++ AG  +PK   K+     TP+K +KP   AG  +
Sbjct: 1226 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1285

Query: 171  VAKSAKKVKTP-----QPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
             +  A +         QP    ++  +A   K      +  + KV    K + +K
Sbjct: 1286 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1340



 Score = 29.6 bits (65), Expect = 2.1
 Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 17/217 (7%)

Query: 16   EKTPVKKKAKKAGATAGKRKASGP-PVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
            E  P +     +  T GK  ASG  P      K  A + + S ++L +        G   
Sbjct: 1246 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS-NITQCLLGQPW 1304

Query: 75   EKNNSRIKLGLKSLVS------KGTLVQTKGTGASGSFKLNKKAASGEGK----PKAKKA 124
              N ++++  +  +++      +  +V T    +   ++  K+  SG+      P++KK 
Sbjct: 1305 PLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKK 1364

Query: 125  GAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP-----KKVKKPATAAGTKKVAKSAKKVK 179
                  +   A+  P+K +  +  K    K       KK K    + G K   +   +  
Sbjct: 1365 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1424

Query: 180  TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
                +   +S  K+K  K K+ K K  K K  K KKA
Sbjct: 1425 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1461



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDS 693


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 543 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 602

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 603 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 662

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 663 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 722

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 723 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 782



 Score = 44.3 bits (103), Expect = 8e-05
 Identities = 58/254 (22%), Positives = 95/254 (37%), Gaps = 53/254 (20%)

Query: 17  KTPVKKKAKKAGATAGK--RKASGPPVSELI--------------TKAVAASKERSGVSL 60
           K   K + +KAG T       A+G  V+ L+              T  V+ ++E   V  
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPA 181

Query: 61  --AALKKALAAAGY----------DVEKNNSRIKLGLKSLVSKGTLVQTKGT-------- 100
             AA K  + +AG             ++ +  +K   K L  +      KGT        
Sbjct: 182 FGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPA 241

Query: 101 --GASGSFKLNKKA---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPK 149
             G +G+     KA         +S E     ++  AAK    A A+ K  +V  A+ P 
Sbjct: 242 PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPA 301

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPK 209
           K   ++P+K   PA    T      A+  K  +  +++   + ++   P  AKP    P+
Sbjct: 302 K---ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQ 358

Query: 210 VTKAK---KAAPKK 220
           V  A    K +P+K
Sbjct: 359 VRAASAPAKESPRK 372



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 41/157 (26%), Positives = 57/157 (36%), Gaps = 25/157 (15%)

Query: 14   PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
            PA +TP  KK KK GA  G   +  P  +   +K  A   + SG               D
Sbjct: 1277 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG---------------D 1321

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK--KAGAAKPRK 131
            V++   +  LG +    +      KG G              +  PK+K  K  + K +K
Sbjct: 1322 VKEKKGKGSLGSQGAKDEPEEELQKGMGTV--------EGGDQSNPKSKKEKKKSDKRKK 1373

Query: 132  PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
                 +K KK   A+T         KK KK  TA  T
Sbjct: 1374 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1410



 Score = 32.3 bits (72), Expect = 0.33
 Identities = 28/125 (22%), Positives = 48/125 (38%), Gaps = 18/125 (14%)

Query: 113 ASGEGKPKAKKAGAAKP--------RKPAGAAKKPKKVAGAATPKK----------SIKK 154
           + GE       A   KP        R PAG A  P +   A+TP+K          S  +
Sbjct: 864 SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 923

Query: 155 TPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK 214
           +  +   PAT   T  +  +   + T  P+ A K+     +   ++++   GK +   A 
Sbjct: 924 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPAT 983

Query: 215 KAAPK 219
           + + K
Sbjct: 984 QVSKK 988



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 228 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 270

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 271 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 304

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 305 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 362

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 363 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 396



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 116  EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK-----TPKKVKKPATAAGTKK 170
            +  P      AAK         KP++ AG  +PK   K+     TP+K +KP   AG  +
Sbjct: 1149 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1208

Query: 171  VAKSAKKVKTP-----QPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
             +  A +         QP    ++  +A   K      +  + KV    K + +K
Sbjct: 1209 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1263



 Score = 29.6 bits (65), Expect = 2.1
 Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 17/217 (7%)

Query: 16   EKTPVKKKAKKAGATAGKRKASGP-PVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
            E  P +     +  T GK  ASG  P      K  A + + S ++L +        G   
Sbjct: 1169 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS-NITQCLLGQPW 1227

Query: 75   EKNNSRIKLGLKSLVS------KGTLVQTKGTGASGSFKLNKKAASGEGK----PKAKKA 124
              N ++++  +  +++      +  +V T    +   ++  K+  SG+      P++KK 
Sbjct: 1228 PLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKK 1287

Query: 125  GAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP-----KKVKKPATAAGTKKVAKSAKKVK 179
                  +   A+  P+K +  +  K    K       KK K    + G K   +   +  
Sbjct: 1288 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1347

Query: 180  TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
                +   +S  K+K  K K+ K K  K K  K KKA
Sbjct: 1348 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1384



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 531 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 590

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 591 KAGTATSPAGSSPAVAGGTQRPAEDS 616


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 43/241 (17%)

Query: 2   SETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLA 61
           ++ +P     PAP +   V  + K  GA    ++A  P      ++  + S+E       
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVK-GGALPPAKRAKKPEEESESSEEGSESEEE------ 282

Query: 62  ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGT----------GASGSFKLNKK 111
                 A AG       S++K   K L  +      KGT          G +G+     K
Sbjct: 283 ------APAG-----TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331

Query: 112 A---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKP 162
           A         +S E     ++  AAK    A A+ K  +V  A+ P K   ++P+K   P
Sbjct: 332 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK---ESPRKGAAP 388

Query: 163 ATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK---KAAPK 219
           A    T      A+  K  +  +++   + ++   P  AKP    P+V  A    K +P+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448

Query: 220 K 220
           K
Sbjct: 449 K 449



 Score = 40.4 bits (93), Expect = 0.001
 Identities = 41/157 (26%), Positives = 57/157 (36%), Gaps = 25/157 (15%)

Query: 14   PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYD 73
            PA +TP  KK KK GA  G   +  P  +   +K  A   + SG               D
Sbjct: 1316 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASG---------------D 1360

Query: 74   VEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAK--KAGAAKPRK 131
            V++   +  LG +    +      KG G              +  PK+K  K  + K +K
Sbjct: 1361 VKEKKGKGSLGSQGAKDEPEEELQKGMGTV--------EGGDQSNPKSKKEKKKSDKRKK 1412

Query: 132  PAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGT 168
                 +K KK   A+T         KK KK  TA  T
Sbjct: 1413 DKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQT 1449



 Score = 34.7 bits (78), Expect = 0.066
 Identities = 46/202 (22%), Positives = 74/202 (36%), Gaps = 27/202 (13%)

Query: 21  KKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSR 80
           K+KA++  A   K+     P+S   T   +  +E +    A     LA+       N+S 
Sbjct: 62  KRKAEEDAALQAKKTRVSDPIS---TSESSEEEEEAEAETAKATPRLAST------NSSV 112

Query: 81  IKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPK 140
           +   L S + +    +T+  G +G    N       GK  A       PRK A  +    
Sbjct: 113 LGADLPSSMKEKAKAETEKAGKTG----NSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168

Query: 141 KVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAK----AKAP 196
            V+          +T ++   PA  A  K    SA +  +     ++ S         + 
Sbjct: 169 LVS----------ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSV 218

Query: 197 KPKAAKPKSGKPKVTKAKKAAP 218
           KP   K  S   K + A+KAAP
Sbjct: 219 KPAQVKASSVSTKESPARKAAP 240



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 347

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 348 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 381

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 382 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 439

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 27/115 (23%), Positives = 44/115 (38%), Gaps = 10/115 (8%)

Query: 116  EGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKK-----TPKKVKKPATAAGTKK 170
            +  P      AAK         KP++ AG  +PK   K+     TP+K +KP   AG  +
Sbjct: 1188 DSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1247

Query: 171  VAKSAKKVKTP-----QPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKAAPKK 220
             +  A +         QP    ++  +A   K      +  + KV    K + +K
Sbjct: 1248 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1302



 Score = 30.8 bits (68), Expect = 0.96
 Identities = 26/113 (23%), Positives = 43/113 (38%), Gaps = 18/113 (15%)

Query: 113  ASGEGKPKAKKAGAAKP--------RKPAGAAKKPKKVAGAATPKK----------SIKK 154
            + GE       A   KP        R PAG A  P +   A+TP+K          S  +
Sbjct: 941  SDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSE 1000

Query: 155  TPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGK 207
            +  +   PAT   T  +  +   + T  P+ A K+     +   ++++   GK
Sbjct: 1001 SEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGK 1053



 Score = 29.6 bits (65), Expect = 2.1
 Identities = 46/217 (21%), Positives = 82/217 (37%), Gaps = 17/217 (7%)

Query: 16   EKTPVKKKAKKAGATAGKRKASGP-PVSELITKAVAASKERSGVSLAALKKALAAAGYDV 74
            E  P +     +  T GK  ASG  P      K  A + + S ++L +        G   
Sbjct: 1208 EAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS-NITQCLLGQPW 1266

Query: 75   EKNNSRIKLGLKSLVS------KGTLVQTKGTGASGSFKLNKKAASGEGK----PKAKKA 124
              N ++++  +  +++      +  +V T    +   ++  K+  SG+      P++KK 
Sbjct: 1267 PLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKK 1326

Query: 125  GAAKPRKPAGAAKKPKKVAGAATPKKSIKKTP-----KKVKKPATAAGTKKVAKSAKKVK 179
                  +   A+  P+K +  +  K    K       KK K    + G K   +   +  
Sbjct: 1327 KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKG 1386

Query: 180  TPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAKKA 216
                +   +S  K+K  K K+ K K  K K  K KKA
Sbjct: 1387 MGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKA 1423



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDS 693


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 45.1 bits (105), Expect = 5e-05
 Identities = 59/240 (24%), Positives = 84/240 (35%), Gaps = 27/240 (11%)

Query: 2   SETAPLAPTIPA--PAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVS 59
           SE AP A T     PA K P  K   K   T    K +   V     +    +   +G S
Sbjct: 620 SEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSS 679

Query: 60  LAAL---------KKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSF-KLN 109
            A             +   +  + EK    + +G    V KG  V+       GS  +  
Sbjct: 680 PAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 110 KKAASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATP---KKSIKKTPKKVKKPATAA 166
                G+  P   +  A K      + ++      AA+P   K S+KKT  K    A  A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 167 GTKKVAKSAK-KVKTPQPKKAAKSPAKAKAP-----------KPKAAKPKSGKPKVTKAK 214
            + K   SA  KV T   +   +SP+K K P           +  A+ P  GK   T A+
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQ 859



 Score = 43.5 bits (101), Expect = 1e-04
 Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 43/241 (17%)

Query: 2   SETAPLAPTIPAPAEKTPVKKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLA 61
           ++ +P     PAP +   V  + K  GA    ++A  P      ++  + S+E       
Sbjct: 230 TKESPARKAAPAPGKVGDVTPQVK-GGALPPAKRAKKPEEESESSEEGSESEEE------ 282

Query: 62  ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGT----------GASGSFKLNKK 111
                 A AG       S++K   K L  +      KGT          G +G+     K
Sbjct: 283 ------APAG-----TRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTK 331

Query: 112 A---------ASGEGKPKAKKAGAAKPRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKP 162
           A         +S E     ++  AAK    A A+ K  +V  A+ P K   ++P+K   P
Sbjct: 332 AGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK---ESPRKGAAP 388

Query: 163 ATAAGTKKVAKSAKKVKTPQPKKAAKSPAKAKAPKPKAAKPKSGKPKVTKAK---KAAPK 219
           A    T      A+  K  +  +++   + ++   P  AKP    P+V  A    K +P+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448

Query: 220 K 220
           K
Sbjct: 449 K 449



 Score = 34.7 bits (78), Expect = 0.066
 Identities = 46/202 (22%), Positives = 74/202 (36%), Gaps = 27/202 (13%)

Query: 21  KKKAKKAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSR 80
           K+KA++  A   K+     P+S   T   +  +E +    A     LA+       N+S 
Sbjct: 62  KRKAEEDAALQAKKTRVSDPIS---TSESSEEEEEAEAETAKATPRLAST------NSSV 112

Query: 81  IKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKKPK 140
           +   L S + +    +T+  G +G    N       GK  A       PRK A  +    
Sbjct: 113 LGADLPSSMKEKAKAETEKAGKTG----NSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168

Query: 141 KVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKVKTPQPKKAAKSPAK----AKAP 196
            V+          +T ++   PA  A  K    SA +  +     ++ S         + 
Sbjct: 169 LVS----------ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSV 218

Query: 197 KPKAAKPKSGKPKVTKAKKAAP 218
           KP   K  S   K + A+KAAP
Sbjct: 219 KPAQVKASSVSTKESPARKAAP 240



 Score = 31.2 bits (69), Expect = 0.73
 Identities = 54/214 (25%), Positives = 83/214 (38%), Gaps = 56/214 (26%)

Query: 13  APAEKTPVKKKAK----KAGATAGKRKASGPPVSELITKAVAASKERSGVSLAALKKALA 68
           APA+ TP K        KAGA A + KA  P        + ++S+E S            
Sbjct: 305 APAKGTPGKGATPAPPGKAGAVASQTKAGKPEED-----SESSSEESS------------ 347

Query: 69  AAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEGKPKAKKAGAAK 128
               D E+     K           L+Q K +G        K +  G     AK++    
Sbjct: 348 ----DSEEETPAAK----------ALLQAKASG--------KTSQVGAASAPAKES---- 381

Query: 129 PRKPAGAAKKPKKVAGAATPKKSIKKTPKKVKKPATAAGTKKVAKSAKKV--KTPQPKKA 186
           PRK  GAA  P    G A  K    K  +  +  +  + +++ A +  K   K PQ + A
Sbjct: 382 PRK--GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA 439

Query: 187 A----KSPAKAKAP-KPKAAKPKSGKPKVTKAKK 215
           +    +SP K  AP  P+   P + + +V K ++
Sbjct: 440 SAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473



 Score = 27.7 bits (60), Expect = 8.1
 Identities = 24/86 (27%), Positives = 33/86 (38%), Gaps = 13/86 (15%)

Query: 103 SGSFKLNKKAASGEGKPKAKKAGAAKPRKPAGAAKK-PKKV------------AGAATPK 149
           S S + +  +A  E  P A  A  AKP       K  PKK              G   P+
Sbjct: 608 SESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPR 667

Query: 150 KSIKKTPKKVKKPATAAGTKKVAKSA 175
           K+   T      PA A GT++ A+ +
Sbjct: 668 KAGTATSPAGSSPAVAGGTQRPAEDS 693


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.300    0.116    0.305 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,642,707
Number of Sequences: 37866
Number of extensions: 430715
Number of successful extensions: 6461
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 532
Number of HSP's that attempted gapping in prelim test: 3364
Number of HSP's gapped (non-prelim): 2158
length of query: 221
length of database: 18,247,518
effective HSP length: 98
effective length of query: 123
effective length of database: 14,536,650
effective search space: 1788007950
effective search space used: 1788007950
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.7 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.