BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4885295 G protein-coupled receptor 12 [Homo sapiens] (334 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 662 0.0 gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 385 e-107 gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 384 e-107 gi|13540517 endothelial differentiation, sphingolipid G-protein-... 131 1e-30 gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 127 2e-29 gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 124 9e-29 gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 124 9e-29 gi|134244587 endothelial differentiation, sphingolipid G-protein... 124 1e-28 gi|119508433 melanocortin 4 receptor [Homo sapiens] 123 2e-28 gi|170671732 melanocortin 3 receptor [Homo sapiens] 123 2e-28 gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 120 2e-27 gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 120 2e-27 gi|5174535 melanocortin 5 receptor [Homo sapiens] 118 6e-27 gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 118 8e-27 gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 115 7e-26 gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 115 7e-26 gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 115 7e-26 gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 115 7e-26 gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 115 7e-26 gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 115 7e-26 gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] 112 5e-25 gi|193083134 melanocortin 1 receptor [Homo sapiens] 108 7e-24 gi|4505127 melanocortin 2 receptor [Homo sapiens] 105 7e-23 gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] 100 1e-21 gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 96 6e-20 gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 92 8e-19 gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 92 8e-19 gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 92 8e-19 gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 92 8e-19 gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 92 8e-19 >gi|4885295 G protein-coupled receptor 12 [Homo sapiens] Length = 334 Score = 662 bits (1707), Expect = 0.0 Identities = 334/334 (100%), Positives = 334/334 (100%) Query: 1 MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC 60 MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC Sbjct: 1 MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC 60 Query: 61 ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI 120 ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI Sbjct: 61 ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI 120 Query: 121 VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN 180 VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN Sbjct: 121 VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN 180 Query: 181 CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT 240 CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT Sbjct: 181 CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT 240 Query: 241 SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI 300 SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI Sbjct: 241 SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI 300 Query: 301 YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV 334 YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV Sbjct: 301 YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV 334 >gi|4885325 G protein-coupled receptor 3 [Homo sapiens] Length = 330 Score = 385 bits (988), Expect = e-107 Identities = 186/326 (57%), Positives = 240/326 (73%), Gaps = 1/326 (0%) Query: 10 SGLPRDYLDAAAAE-NISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLI 68 +G P +L A + N+S+ + P P WD+VLC SGTL+SCENA+VV I Sbjct: 5 AGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAI 64 Query: 69 IFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASV 128 I P+ RAPMFLL+GSLA+ADLLAG+GL+ +F + + S LV +G++ +F+AS+ Sbjct: 65 IVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASI 124 Query: 129 CSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTC 188 SLLAITVDRYLSLY ALTY+SE TVT TYVML ++WG ++ LGLLPV+ WNCL +TC Sbjct: 125 GSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTC 184 Query: 189 SVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRK 248 VV PL+KN+ +L+++F +F +MLQLY QIC+IV RHA QIALQ H L SHYV TRK Sbjct: 185 GVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRK 244 Query: 249 GVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEI 308 G++TLA++LG FAACW+PFT+Y L+ D P +YTY TLLPATYNS+INP+IYAFRNQ++ Sbjct: 245 GIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDV 304 Query: 309 QKALCLICCGCIPSSLAQRARSPSDV 334 QK L +CC C S + R+RSPSDV Sbjct: 305 QKVLWAVCCCCSSSKIPFRSRSPSDV 330 >gi|4885341 G protein-coupled receptor 6 [Homo sapiens] Length = 362 Score = 384 bits (985), Expect = e-107 Identities = 187/319 (58%), Positives = 241/319 (75%), Gaps = 1/319 (0%) Query: 17 LDAAAAENISAAVSSRVPAVEPEPEL-VVNPWDIVLCTSGTLISCENAIVVLIIFHNPSL 75 L A N S +SS++ A P L VNPWD++LC SGT+I+ ENA+VV +I P+L Sbjct: 44 LGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPAL 103 Query: 76 RAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAIT 135 R PMF+L+GSLA ADLLAG GLI +FVF YL+ SE L+T+G +VASF+ASV SLLAIT Sbjct: 104 RTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAIT 163 Query: 136 VDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLT 195 VDRYLSLY ALTY+S RT+ +++L W S+ LGLLPV+GWNCL + + CSVVRPL Sbjct: 164 VDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLA 223 Query: 196 KNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAI 255 +++ A+LS +F +F +ML LY++IC++V RHAHQIALQ H LA H TRKGV TLA+ Sbjct: 224 RSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAV 283 Query: 256 ILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLI 315 +LGTF A W+PF +Y ++ + P++YTYATLLPATYNS+INP+IYAFRNQEIQ+AL L+ Sbjct: 284 VLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLL 343 Query: 316 CCGCIPSSLAQRARSPSDV 334 CGC S + R+RSPS+V Sbjct: 344 LCGCFQSKVPFRSRSPSEV 362 >gi|13540517 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [Homo sapiens] Length = 398 Score = 131 bits (329), Expect = 1e-30 Identities = 102/292 (34%), Positives = 146/292 (50%), Gaps = 27/292 (9%) Query: 48 DIVLCTSG-TLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA-- 104 D V+C + I EN V+L++ +P APMFLL+GSL L+DLLAG N + + Sbjct: 39 DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGP 98 Query: 105 -YLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYY---ALTYHSERTVTFTYVM 160 L S A G + + +ASV SLLAI ++R L++ A RT+ M Sbjct: 99 LTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLA----M 154 Query: 161 LVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQ 219 WG S+ LGLLP +GWNCL CS V PL K ++F+ + A + LY + Sbjct: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214 Query: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVS-----TLAIILGTFAACWMPFTLYSLIA 274 I V +A ++ + T+ RK S TL+++L F ACW P L L+ Sbjct: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLL-LLL 273 Query: 275 DYTYPSIYTYATLLP-------ATYNSIINPVIYAFRNQEIQKALC-LICCG 318 D P+ T LL A NS++NP+IY N++++ AL L+CCG Sbjct: 274 DVACPA-RTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCG 324 >gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] Length = 351 Score = 127 bits (318), Expect = 2e-29 Identities = 92/295 (31%), Positives = 149/295 (50%), Gaps = 23/295 (7%) Query: 46 PWDIVLCTSGTLISC----ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNF 101 P D+V+ G +S N +V+ I N P++ L+G+LA ADL AG+ + Sbjct: 30 PKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVA----Y 85 Query: 102 VFAYLLQSEATKLVTI-------GLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTV 154 +F T +++ GL+ S +ASV +LLAI V+R+ S+ A+ HS Sbjct: 86 LFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSV-MAVQLHSRLPR 144 Query: 155 TFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRP-LTKNNAAILSVSFLFMFALM 213 +++V +W ++ LGLLP W+CL CS + P L+++ A+ ++S L +F LM Sbjct: 145 GRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLM 204 Query: 214 LQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI 273 + +Y +I V R ++A +H + TT V T+ IILG F CW P + L+ Sbjct: 205 VAVYTRIFFYVRRRVQRMA-EHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLL 263 Query: 274 ADYTYPSIYTYAT----LLPATYNSIINPVIYAFRNQEIQKAL-CLICCGCIPSS 323 S A LL A NS++N +Y+ R+ E+++ L+CC C+ S Sbjct: 264 DGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQS 318 >gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] Length = 382 Score = 124 bits (312), Expect = 9e-29 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 26/300 (8%) Query: 49 IVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQ 108 I++C I EN V+L I+ PM+ IG+LAL+DLLAG+ N + + Sbjct: 53 ILICC---FIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATT 109 Query: 109 SEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLW 165 + T + G + + SASV SLLAI ++RY+++ + H+ ++++ W Sbjct: 110 YKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITML-KMKLHNGSNNFRLFLLISACW 168 Query: 166 GTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIV 224 S+ LG LP+MGWNC+ S+CS V PL K+ + F + ++ LY +I +V Sbjct: 169 VISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLV 228 Query: 225 MRHAHQIALQHHFLATSHYVTTRKGVS---TLAIILGTFAACWMPFTLYSLI-------- 273 + ++ + + S ++ K ++ T+ I+L F ACW P + L+ Sbjct: 229 RTRSRRLTFRKNISKASR--SSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT 286 Query: 274 ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLI--CCGCIPSSLAQRARSP 331 D + + Y L+ A NS NP+IY N+E+++A I CC C A + + P Sbjct: 287 CDILFRAEY---FLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP 343 >gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] Length = 353 Score = 124 bits (312), Expect = 9e-29 Identities = 87/303 (28%), Positives = 154/303 (50%), Gaps = 24/303 (7%) Query: 49 IVLCTSGTL----ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA 104 IVLC GT I N++V+ + N P + L+ +LA AD AGI +VF Sbjct: 32 IVLCV-GTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIA----YVFL 86 Query: 105 YLLQSEATKLVTI-------GLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFT 157 +K +T+ GL+ +S +AS+ +LL I V+R++S+ + HS T Sbjct: 87 MFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIM-RMRVHSNLTKKRV 145 Query: 158 YVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQL 216 ++++++W +I +G +P +GWNCL + S CS + P+ +++ +VS L F +M+ + Sbjct: 146 TLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVV 205 Query: 217 YIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY 276 Y++I V R + ++ H + S T K + T+ +LG F CW P + L+ Sbjct: 206 YLRIYVYVKRKTNVLS-PHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGL 264 Query: 277 TYPSIYTYAT----LLPATYNSIINPVIYAFRNQEIQKAL-CLICCGCIPSSLAQRARSP 331 LL A NS++NP+IY+++++++ + +ICC + + +R P Sbjct: 265 NCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIP 324 Query: 332 SDV 334 S V Sbjct: 325 STV 327 >gi|134244587 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Homo sapiens] Length = 353 Score = 124 bits (311), Expect = 1e-28 Identities = 87/314 (27%), Positives = 154/314 (49%), Gaps = 29/314 (9%) Query: 9 LSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLI 68 + L +YL+ + + E V + + ++LC + I EN +V++ Sbjct: 1 MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCA---IVVENLLVLIA 57 Query: 69 IFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTI---GLIVASFS 125 + N + M+L +G+LA +DLLAG+ + N + + + T + G + S Sbjct: 58 VARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLS 117 Query: 126 ASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDE 185 ASV SLLAI ++R++++ Y S+++ +++ W S+ LG LP++GWNCL Sbjct: 118 ASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIGASWLISLVLGGLPILGWNCLGHL 176 Query: 186 STCSVVRPLTKNNAAILSVS-FLFMFALMLQLYIQI-CKIVMRHAHQIALQHHFLATSHY 243 CS V PL + + V+ F + ++ LY++I C + HA A Q Sbjct: 177 EACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQ--------- 227 Query: 244 VTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATY-------NSII 296 T + T+ I+LG F CW+P L+ DY P +++ L A Y NS++ Sbjct: 228 --TLALLKTVTIVLGVFIVCWLP-AFSILLLDYACP-VHSCPILYKAHYFFAVSTLNSLL 283 Query: 297 NPVIYAFRNQEIQK 310 NPVIY +R++++++ Sbjct: 284 NPVIYTWRSRDLRR 297 >gi|119508433 melanocortin 4 receptor [Homo sapiens] Length = 332 Score = 123 bits (309), Expect = 2e-28 Identities = 91/294 (30%), Positives = 143/294 (48%), Gaps = 34/294 (11%) Query: 41 ELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITN 100 +L V+P V T G + EN +V++ I N +L +PM+ I SLA+AD+L + + Sbjct: 43 QLFVSPE--VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSE 100 Query: 101 FVFAYLLQSEATKL---------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSE 151 + LL S T V +I +S AS+CSLL+I VDRY +++YAL YH+ Sbjct: 101 TIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI 160 Query: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211 TV +++ +W G+L + + +S+ ++ L F M A Sbjct: 161 MTVKRVGIIISCIWAACTVSGILFI-----IYSDSSAVII---------CLITMFFTMLA 206 Query: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYS 271 LM LY+ + + H +IA+ KG TL I++G F CW PF L+ Sbjct: 207 LMASLYVHMFLMARLHIKRIAVLPG-TGAIRQGANMKGAITLTILIGVFVVCWAPFFLHL 265 Query: 272 L--IADYTYPSIYTYAT-----LLPATYNSIINPVIYAFRNQEIQKALC-LICC 317 + I+ P + + L+ NSII+P+IYA R+QE++K +ICC Sbjct: 266 IFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319 >gi|170671732 melanocortin 3 receptor [Homo sapiens] Length = 323 Score = 123 bits (309), Expect = 2e-28 Identities = 94/326 (28%), Positives = 148/326 (45%), Gaps = 48/326 (14%) Query: 15 DYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPS 74 ++L A N S++ ++PE V + G + EN +V+L + N + Sbjct: 19 EHLQAPFFSNQSSSAFCEQVFIKPE----------VFLSLGIVSLLENILVILAVVRNGN 68 Query: 75 LRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKL----------VTIGLIVASF 124 L +PM+ + SLA+AD+L + + ++ S+ + +I S Sbjct: 69 LHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISL 128 Query: 125 SASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRD 184 AS+C+LLAI VDRY++++YAL YHS TV ++V +W +C G+ V+ Sbjct: 129 VASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIW---VCCGVCGVV------- 178 Query: 185 ESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQI-ALQHHFLATSHY 243 +V +K L F M LM LY+ + H +I AL Sbjct: 179 ----FIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQ 234 Query: 244 VTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----------IYTYATLLPATYN 293 + KG T+ I+LG F CW PF L+ L+ T P+ TY L+ N Sbjct: 235 HSCMKGAVTITILLGVFIFCWAPFFLH-LVLIITCPTNPYCICYTAHFNTYLVLIMC--N 291 Query: 294 SIINPVIYAFRNQEIQKALCLICCGC 319 S+I+P+IYAFR+ E++ I CGC Sbjct: 292 SVIDPLIYAFRSLELRNTFREILCGC 317 >gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 120 bits (300), Expect = 2e-27 Identities = 84/283 (29%), Positives = 145/283 (51%), Gaps = 18/283 (6%) Query: 58 ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIG---LITNFVFAYLLQSEATKL 114 I N +V++ I+ N P++ L+ +LA AD AG+ L+ N + +T L Sbjct: 63 IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL 122 Query: 115 VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLL 174 + GLI S +ASV +LLAI ++R+++++ + H+ + V++V++W +I +G + Sbjct: 123 LRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAI 181 Query: 175 PVMGWNCLRDESTCSVVRPLTKNNAAILSVSF-LFMFALMLQLYIQICKIVMRHAHQIAL 233 P +GWNC+ D CS + PL ++ + F L F +M+ LY I V + +++ Sbjct: 182 PSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS- 240 Query: 234 QHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----IYTYATLLP 289 +H + T + T+ I+LG F CW P L L+ D P Y LL Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCDVLAYEKFFLLL 299 Query: 290 ATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPS 332 A +NS +NP+IY++R++E+ I C QR+ +P+ Sbjct: 300 AEFNSAMNPIIYSYRDKEMSATFRQILC-------CQRSENPT 335 >gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 120 bits (300), Expect = 2e-27 Identities = 84/283 (29%), Positives = 145/283 (51%), Gaps = 18/283 (6%) Query: 58 ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIG---LITNFVFAYLLQSEATKL 114 I N +V++ I+ N P++ L+ +LA AD AG+ L+ N + +T L Sbjct: 63 IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL 122 Query: 115 VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLL 174 + GLI S +ASV +LLAI ++R+++++ + H+ + V++V++W +I +G + Sbjct: 123 LRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAI 181 Query: 175 PVMGWNCLRDESTCSVVRPLTKNNAAILSVSF-LFMFALMLQLYIQICKIVMRHAHQIAL 233 P +GWNC+ D CS + PL ++ + F L F +M+ LY I V + +++ Sbjct: 182 PSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS- 240 Query: 234 QHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----IYTYATLLP 289 +H + T + T+ I+LG F CW P L L+ D P Y LL Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCDVLAYEKFFLLL 299 Query: 290 ATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPS 332 A +NS +NP+IY++R++E+ I C QR+ +P+ Sbjct: 300 AEFNSAMNPIIYSYRDKEMSATFRQILC-------CQRSENPT 335 >gi|5174535 melanocortin 5 receptor [Homo sapiens] Length = 325 Score = 118 bits (296), Expect = 6e-27 Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 33/286 (11%) Query: 50 VLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQS 109 V T G + EN +V+ I N +L +PM+ + SLA+AD+L + + YLL + Sbjct: 42 VFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNN 101 Query: 110 EATKL----------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYV 159 + + V +I S AS+CSLLAI VDRY++++YAL YH T + Sbjct: 102 KHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGA 161 Query: 160 MLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQ 219 ++ +W G++ + L EST ++ ++S+ F +F L++ LYI Sbjct: 162 IIAGIWAFCTGCGIVFI-----LYSESTYVIL--------CLISMFFAMLF-LLVSLYIH 207 Query: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYP 279 + + H +IA +++ T+ +G T+ ++LG F CW PF L+ + Sbjct: 208 MFLLARTHVKRIAALPG-ASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQ 266 Query: 280 SIYT-------YATLLPATYNSIINPVIYAFRNQEIQKALC-LICC 317 ++Y L+ NS+++P+IYAFR+QE++K +ICC Sbjct: 267 NLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312 >gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] Length = 378 Score = 118 bits (295), Expect = 8e-27 Identities = 83/289 (28%), Positives = 141/289 (48%), Gaps = 19/289 (6%) Query: 49 IVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA---Y 105 +V+C+ I EN +V++ I+ N M+ IG+LAL DLLAGI N + + Sbjct: 47 LVICS---FIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKT 103 Query: 106 LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLW 165 S + G + + AS CSLLAI ++R+L++ Y + + ++++ M W Sbjct: 104 FSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHR-VFLLIGMCW 162 Query: 166 GTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIV 224 + LG LP++GWNCL + CS + PL +K A F + ++ LY +I +V Sbjct: 163 LIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLV 222 Query: 225 MRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI----ADYTYPS 280 + ++A H+ S + + T+ I++ F ACW P + LI P Sbjct: 223 KSSSRKVA-NHNNSERSMAL-----LRTVVIVVSVFIACWSPLFILFLIDVACRVQACPI 276 Query: 281 IY-TYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRA 328 ++ ++ A NS +NPVIY ++E+++A + C C+ RA Sbjct: 277 LFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARA 325 >gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403 Query: 308 IQKA 311 ++ A Sbjct: 404 LRHA 407 >gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403 Query: 308 IQKA 311 ++ A Sbjct: 404 LRHA 407 >gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403 Query: 308 IQKA 311 ++ A Sbjct: 404 LRHA 407 >gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403 Query: 308 IQKA 311 ++ A Sbjct: 404 LRHA 407 >gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403 Query: 308 IQKA 311 ++ A Sbjct: 404 LRHA 407 >gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] Length = 439 Score = 115 bits (287), Expect = 7e-26 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%) Query: 42 LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95 +V+NP ++ T GT EN +V+ +I H+ SLR P + IGSLA+ADLL + Sbjct: 76 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 135 Query: 96 GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152 + +F+ ++ + ++ L +G + ASF+ASV SL +DRY+S++ L Y Sbjct: 136 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 195 Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209 T V ++W +I + +LP++GWNC + +S CS + P + + S L + Sbjct: 196 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 255 Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252 F + +YI + H+H + + S + T + T Sbjct: 256 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 311 Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307 L +IL CW P +Y + + +++ + ++L NS +NP+IYA R+++ Sbjct: 312 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 370 Query: 308 IQKA 311 ++ A Sbjct: 371 LRHA 374 >gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] Length = 360 Score = 112 bits (280), Expect = 5e-25 Identities = 88/278 (31%), Positives = 139/278 (50%), Gaps = 22/278 (7%) Query: 50 VLCTS-GTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGIGLITNFVFAYL- 106 VLCT G L + EN V+ +I + LR P +L IGSLA AD LA + +FV ++ Sbjct: 38 VLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97 Query: 107 --LQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVML 164 + S+A L+ IG + +F+ASV SLL +DRYL L Y +Y + T V L ++ Sbjct: 98 HGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIM 157 Query: 165 WGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFL-FMFALMLQLYIQICKI 223 W S + LP+MGW C CS + PL N+ + + F+ F+F+ ++ Y + + Sbjct: 158 WVLSALVSYLPLMGWTCC--PRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHV--L 213 Query: 224 VMRHAHQIALQHH----FLATSHYVTTRKGVSTLAIILGTFAACWMP------FTLYSLI 273 H H +L H + + TL ++L CW P +L + + Sbjct: 214 WKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTL 273 Query: 274 ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKA 311 +D + + ++L NS++NPVIYA R+ EI+ + Sbjct: 274 SDQV-KKAFAFCSML-CLINSMVNPVIYALRSGEIRSS 309 >gi|193083134 melanocortin 1 receptor [Homo sapiens] Length = 317 Score = 108 bits (270), Expect = 7e-24 Identities = 93/288 (32%), Positives = 137/288 (47%), Gaps = 31/288 (10%) Query: 42 LVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLL-AGIGLITN 100 L V+ D + + G + ENA+VV I N +L +PM+ I LAL+DLL +G ++ Sbjct: 36 LEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLET 95 Query: 101 FVFAYL----LQSEATKLVTIGLIV-----ASFSASVCSLLAITVDRYLSLYYALTYHSE 151 V L L + A L + ++ +S +S+C L AI VDRY+S++YAL YHS Sbjct: 96 AVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSI 155 Query: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211 T+ + +W S+ L + ++ + L V FL M Sbjct: 156 VTLPRARRAVAAIWVASVVFSTLFIAYYDHVAV--------------LLCLVVFFLAMLV 201 Query: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPF---- 267 LM LY+ + +HA IA H H KG TL I+LG F CW PF Sbjct: 202 LMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHL 261 Query: 268 TLYSLIADY-TYPSIYTYATLLPATY--NSIINPVIYAFRNQEIQKAL 312 TL L ++ T I+ L A N+II+P+IYAF +QE+++ L Sbjct: 262 TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTL 309 >gi|4505127 melanocortin 2 receptor [Homo sapiens] Length = 297 Score = 105 bits (261), Expect = 7e-23 Identities = 78/269 (28%), Positives = 126/269 (46%), Gaps = 41/269 (15%) Query: 61 ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL-----------LQS 109 EN IV+L +F N +L+APM+ I SLA++D+L + I + L ++ Sbjct: 41 ENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFET 100 Query: 110 EATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSI 169 A ++ L V S S+ SL I DRY+++++AL YHS T+ T V+L ++W Sbjct: 101 TADDIID-SLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCT 159 Query: 170 CLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAH 229 G+ V+ + + T + + PL M +L LY+ + + H Sbjct: 160 GTGITMVIFSHHVPTVITFTSLFPL--------------MLVFILCLYVHMFLLARSHTR 205 Query: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY--TYPSIYTYATL 287 +I+ KG TL I+LG F CW PF L+ L+ + + P Y +L Sbjct: 206 KISTLPR--------ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSL 257 Query: 288 LPAT-----YNSIINPVIYAFRNQEIQKA 311 N++I+P IYAFR+ E++ A Sbjct: 258 FQVNGMLIMCNAVIDPFIYAFRSPELRDA 286 >gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens] Length = 318 Score = 100 bits (250), Expect = 1e-21 Identities = 70/273 (25%), Positives = 134/273 (49%), Gaps = 15/273 (5%) Query: 62 NAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL---LQSEATKLVTIG 118 N +V+ ++ NPSL+ F I SLALAD+ G+ ++ + L + + +T Sbjct: 30 NVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCL 89 Query: 119 LIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMG 178 L++ + AS+ SLLAI VDRYL + + Y T ++ L + W S +GL P+ G Sbjct: 90 LLIFTH-ASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFG 148 Query: 179 WNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQI---CKI------VMRHAH 229 WN V L+ +++ + ++ F+ + ++I + C I ++R+ Sbjct: 149 WNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKL 208 Query: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYT--YPSIYTYATL 287 + L + + Y K +L ++L FA W+P ++ + I + P + Y + Sbjct: 209 SLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGI 268 Query: 288 LPATYNSIINPVIYAFRNQEIQKALCLICCGCI 320 L + NS++NP++YA++ ++ ++ LI C+ Sbjct: 269 LLSHANSMMNPIVYAYKIKKFKETYLLILKACV 301 >gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sapiens] Length = 384 Score = 95.5 bits (236), Expect = 6e-20 Identities = 75/289 (25%), Positives = 132/289 (45%), Gaps = 23/289 (7%) Query: 57 LISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA---YLLQSEATK 113 L+ EN +V+ I + R ++ + ++ L+DLL G + N + + + A Sbjct: 59 LVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQW 118 Query: 114 LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGL 173 + GL+ + +AS SLL +R+ ++ + + Y + + W + LG+ Sbjct: 119 FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGM 178 Query: 174 LPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIA 232 LP++GWNCL CS + PL +K V F + A ++ LY I ++V + Sbjct: 179 LPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP 238 Query: 233 LQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYA------- 285 + R+ + T+ +IL F CW P L+AD +++ Sbjct: 239 ------RPAARRKARRLLKTVLMILLAFLVCWGPL-FGLLLADVFGSNLWAQEYLRGMDW 291 Query: 286 TLLPATYNSIINPVIYAFRNQEIQKA-LCLICCGCIPSSLAQRARSPSD 333 L A NS +NP+IY+FR++E+ +A L +CCGC+ + R P D Sbjct: 292 ILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGM----RGPGD 336 >gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] Length = 359 Score = 91.7 bits (226), Expect = 8e-19 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%) Query: 83 IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137 I SLA ADLL + L+ F L+Q E LV L V +AS+ L I++D Sbjct: 59 IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117 Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183 RY ++ L Y ++ T +ML W + LP+M GWN + + Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177 Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241 + ++ V + K A SV +F F LM+ Y +I HAHQI + A+S Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237 Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286 H + T K TL II+G F CW PF + +++ DYT P A Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297 Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317 L NS +NP +YAF N+ ++A +I C Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328 >gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] Length = 428 Score = 91.7 bits (226), Expect = 8e-19 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%) Query: 83 IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137 I SLA ADLL + L+ F L+Q E LV L V +AS+ L I++D Sbjct: 59 IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117 Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183 RY ++ L Y ++ T +ML W + LP+M GWN + + Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177 Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241 + ++ V + K A SV +F F LM+ Y +I HAHQI + A+S Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237 Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286 H + T K TL II+G F CW PF + +++ DYT P A Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297 Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317 L NS +NP +YAF N+ ++A +I C Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328 >gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] Length = 360 Score = 91.7 bits (226), Expect = 8e-19 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%) Query: 83 IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137 I SLA ADLL + L+ F L+Q E LV L V +AS+ L I++D Sbjct: 59 IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117 Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183 RY ++ L Y ++ T +ML W + LP+M GWN + + Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177 Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241 + ++ V + K A SV +F F LM+ Y +I HAHQI + A+S Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237 Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286 H + T K TL II+G F CW PF + +++ DYT P A Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297 Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317 L NS +NP +YAF N+ ++A +I C Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328 >gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] Length = 387 Score = 91.7 bits (226), Expect = 8e-19 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%) Query: 83 IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137 I SLA ADLL + L+ F L+Q E LV L V +AS+ L I++D Sbjct: 59 IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117 Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183 RY ++ L Y ++ T +ML W + LP+M GWN + + Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177 Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241 + ++ V + K A SV +F F LM+ Y +I HAHQI + A+S Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237 Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286 H + T K TL II+G F CW PF + +++ DYT P A Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297 Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317 L NS +NP +YAF N+ ++A +I C Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328 >gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] Length = 378 Score = 91.7 bits (226), Expect = 8e-19 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%) Query: 83 IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137 I SLA ADLL + L+ F L+Q E LV L V +AS+ L I++D Sbjct: 59 IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117 Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183 RY ++ L Y ++ T +ML W + LP+M GWN + + Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177 Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241 + ++ V + K A SV +F F LM+ Y +I HAHQI + A+S Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237 Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286 H + T K TL II+G F CW PF + +++ DYT P A Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297 Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317 L NS +NP +YAF N+ ++A +I C Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.137 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 11,155,623 Number of Sequences: 37866 Number of extensions: 440493 Number of successful extensions: 2897 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 278 Number of HSP's successfully gapped in prelim test: 380 Number of HSP's that attempted gapping in prelim test: 1812 Number of HSP's gapped (non-prelim): 895 length of query: 334 length of database: 18,247,518 effective HSP length: 103 effective length of query: 231 effective length of database: 14,347,320 effective search space: 3314230920 effective search space used: 3314230920 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.