Guide to the Human Genome
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Search of human proteins with 4885295

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
         (334 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885295 G protein-coupled receptor 12 [Homo sapiens]               662   0.0  
gi|4885325 G protein-coupled receptor 3 [Homo sapiens]                385   e-107
gi|4885341 G protein-coupled receptor 6 [Homo sapiens]                384   e-107
gi|13540517 endothelial differentiation, sphingolipid G-protein-...   131   1e-30
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]            127   2e-29
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]         124   9e-29
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]            124   9e-29
gi|134244587 endothelial differentiation, sphingolipid G-protein...   124   1e-28
gi|119508433 melanocortin 4 receptor [Homo sapiens]                   123   2e-28
gi|170671732 melanocortin 3 receptor [Homo sapiens]                   123   2e-28
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]           120   2e-27
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]           120   2e-27
gi|5174535 melanocortin 5 receptor [Homo sapiens]                     118   6e-27
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]         118   8e-27
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]          115   7e-26
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]          115   7e-26
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]          115   7e-26
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]          115   7e-26
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]           115   7e-26
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]          115   7e-26
gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]         112   5e-25
gi|193083134 melanocortin 1 receptor [Homo sapiens]                   108   7e-24
gi|4505127 melanocortin 2 receptor [Homo sapiens]                     105   7e-23
gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]             100   1e-21
gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa...    96   6e-20
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]          92   8e-19
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]          92   8e-19
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]          92   8e-19
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]          92   8e-19
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]          92   8e-19

>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
          Length = 334

 Score =  662 bits (1707), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 1   MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC 60
           MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC
Sbjct: 1   MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISC 60

Query: 61  ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI 120
           ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI
Sbjct: 61  ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLI 120

Query: 121 VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN 180
           VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN
Sbjct: 121 VASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWN 180

Query: 181 CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT 240
           CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT
Sbjct: 181 CLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLAT 240

Query: 241 SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI 300
           SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI
Sbjct: 241 SHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVI 300

Query: 301 YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV 334
           YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
Sbjct: 301 YAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV 334


>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
          Length = 330

 Score =  385 bits (988), Expect = e-107
 Identities = 186/326 (57%), Positives = 240/326 (73%), Gaps = 1/326 (0%)

Query: 10  SGLPRDYLDAAAAE-NISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLI 68
           +G P  +L A +   N+S+   +  P     P      WD+VLC SGTL+SCENA+VV I
Sbjct: 5   AGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAI 64

Query: 69  IFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASV 128
           I   P+ RAPMFLL+GSLA+ADLLAG+GL+ +F   + + S    LV +G++  +F+AS+
Sbjct: 65  IVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASI 124

Query: 129 CSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTC 188
            SLLAITVDRYLSLY ALTY+SE TVT TYVML ++WG ++ LGLLPV+ WNCL   +TC
Sbjct: 125 GSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTC 184

Query: 189 SVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRK 248
            VV PL+KN+  +L+++F  +F +MLQLY QIC+IV RHA QIALQ H L  SHYV TRK
Sbjct: 185 GVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRK 244

Query: 249 GVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEI 308
           G++TLA++LG FAACW+PFT+Y L+ D   P +YTY TLLPATYNS+INP+IYAFRNQ++
Sbjct: 245 GIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDV 304

Query: 309 QKALCLICCGCIPSSLAQRARSPSDV 334
           QK L  +CC C  S +  R+RSPSDV
Sbjct: 305 QKVLWAVCCCCSSSKIPFRSRSPSDV 330


>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
          Length = 362

 Score =  384 bits (985), Expect = e-107
 Identities = 187/319 (58%), Positives = 241/319 (75%), Gaps = 1/319 (0%)

Query: 17  LDAAAAENISAAVSSRVPAVEPEPEL-VVNPWDIVLCTSGTLISCENAIVVLIIFHNPSL 75
           L A    N S  +SS++ A  P   L  VNPWD++LC SGT+I+ ENA+VV +I   P+L
Sbjct: 44  LGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPAL 103

Query: 76  RAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAIT 135
           R PMF+L+GSLA ADLLAG GLI +FVF YL+ SE   L+T+G +VASF+ASV SLLAIT
Sbjct: 104 RTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAIT 163

Query: 136 VDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLT 195
           VDRYLSLY ALTY+S RT+   +++L   W  S+ LGLLPV+GWNCL + + CSVVRPL 
Sbjct: 164 VDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLA 223

Query: 196 KNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAI 255
           +++ A+LS +F  +F +ML LY++IC++V RHAHQIALQ H LA  H   TRKGV TLA+
Sbjct: 224 RSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAV 283

Query: 256 ILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLI 315
           +LGTF A W+PF +Y ++  +  P++YTYATLLPATYNS+INP+IYAFRNQEIQ+AL L+
Sbjct: 284 VLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLL 343

Query: 316 CCGCIPSSLAQRARSPSDV 334
            CGC  S +  R+RSPS+V
Sbjct: 344 LCGCFQSKVPFRSRSPSEV 362


>gi|13540517 endothelial differentiation, sphingolipid
           G-protein-coupled receptor, 8 [Homo sapiens]
          Length = 398

 Score =  131 bits (329), Expect = 1e-30
 Identities = 102/292 (34%), Positives = 146/292 (50%), Gaps = 27/292 (9%)

Query: 48  DIVLCTSG-TLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA-- 104
           D V+C +    I  EN  V+L++  +P   APMFLL+GSL L+DLLAG     N + +  
Sbjct: 39  DAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGP 98

Query: 105 -YLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYY---ALTYHSERTVTFTYVM 160
             L  S A      G +  + +ASV SLLAI ++R L++     A      RT+     M
Sbjct: 99  LTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLA----M 154

Query: 161 LVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQ 219
               WG S+ LGLLP +GWNCL     CS V PL  K       ++F+ + A +  LY +
Sbjct: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214

Query: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVS-----TLAIILGTFAACWMPFTLYSLIA 274
           I   V  +A ++  +     T+     RK  S     TL+++L  F ACW P  L  L+ 
Sbjct: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLL-LLL 273

Query: 275 DYTYPSIYTYATLLP-------ATYNSIINPVIYAFRNQEIQKALC-LICCG 318
           D   P+  T   LL        A  NS++NP+IY   N++++ AL  L+CCG
Sbjct: 274 DVACPA-RTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCG 324


>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
          Length = 351

 Score =  127 bits (318), Expect = 2e-29
 Identities = 92/295 (31%), Positives = 149/295 (50%), Gaps = 23/295 (7%)

Query: 46  PWDIVLCTSGTLISC----ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNF 101
           P D+V+   G  +S      N +V+  I  N     P++ L+G+LA ADL AG+     +
Sbjct: 30  PKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVA----Y 85

Query: 102 VFAYLLQSEATKLVTI-------GLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTV 154
           +F        T  +++       GL+  S +ASV +LLAI V+R+ S+  A+  HS    
Sbjct: 86  LFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSV-MAVQLHSRLPR 144

Query: 155 TFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRP-LTKNNAAILSVSFLFMFALM 213
               +++V +W  ++ LGLLP   W+CL     CS + P L+++  A+ ++S L +F LM
Sbjct: 145 GRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLM 204

Query: 214 LQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI 273
           + +Y +I   V R   ++A +H      +  TT   V T+ IILG F  CW P  +  L+
Sbjct: 205 VAVYTRIFFYVRRRVQRMA-EHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLL 263

Query: 274 ADYTYPSIYTYAT----LLPATYNSIINPVIYAFRNQEIQKAL-CLICCGCIPSS 323
                 S    A     LL A  NS++N  +Y+ R+ E+++    L+CC C+  S
Sbjct: 264 DGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQS 318


>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
          Length = 382

 Score =  124 bits (312), Expect = 9e-29
 Identities = 88/300 (29%), Positives = 147/300 (49%), Gaps = 26/300 (8%)

Query: 49  IVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQ 108
           I++C     I  EN  V+L I+       PM+  IG+LAL+DLLAG+    N + +    
Sbjct: 53  ILICC---FIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATT 109

Query: 109 SEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLW 165
            + T     +  G +  + SASV SLLAI ++RY+++   +  H+       ++++   W
Sbjct: 110 YKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITML-KMKLHNGSNNFRLFLLISACW 168

Query: 166 GTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIV 224
             S+ LG LP+MGWNC+   S+CS V PL  K+     +  F  +   ++ LY +I  +V
Sbjct: 169 VISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLV 228

Query: 225 MRHAHQIALQHHFLATSHYVTTRKGVS---TLAIILGTFAACWMPFTLYSLI-------- 273
              + ++  + +    S   ++ K ++   T+ I+L  F ACW P  +  L+        
Sbjct: 229 RTRSRRLTFRKNISKASR--SSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKT 286

Query: 274 ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLI--CCGCIPSSLAQRARSP 331
            D  + + Y    L+ A  NS  NP+IY   N+E+++A   I  CC C     A + + P
Sbjct: 287 CDILFRAEY---FLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP 343


>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
          Length = 353

 Score =  124 bits (312), Expect = 9e-29
 Identities = 87/303 (28%), Positives = 154/303 (50%), Gaps = 24/303 (7%)

Query: 49  IVLCTSGTL----ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA 104
           IVLC  GT     I   N++V+  +  N     P + L+ +LA AD  AGI     +VF 
Sbjct: 32  IVLCV-GTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIA----YVFL 86

Query: 105 YLLQSEATKLVTI-------GLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFT 157
                  +K +T+       GL+ +S +AS+ +LL I V+R++S+   +  HS  T    
Sbjct: 87  MFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIM-RMRVHSNLTKKRV 145

Query: 158 YVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQL 216
            ++++++W  +I +G +P +GWNCL + S CS + P+ +++     +VS L  F +M+ +
Sbjct: 146 TLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVV 205

Query: 217 YIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY 276
           Y++I   V R  + ++  H   + S   T  K + T+  +LG F  CW P  +  L+   
Sbjct: 206 YLRIYVYVKRKTNVLS-PHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGL 264

Query: 277 TYPSIYTYAT----LLPATYNSIINPVIYAFRNQEIQKAL-CLICCGCIPSSLAQRARSP 331
                         LL A  NS++NP+IY+++++++   +  +ICC    +   + +R P
Sbjct: 265 NCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIP 324

Query: 332 SDV 334
           S V
Sbjct: 325 STV 327


>gi|134244587 endothelial differentiation, sphingolipid
           G-protein-coupled receptor, 5 [Homo sapiens]
          Length = 353

 Score =  124 bits (311), Expect = 1e-28
 Identities = 87/314 (27%), Positives = 154/314 (49%), Gaps = 29/314 (9%)

Query: 9   LSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLI 68
           +  L  +YL+    +         +   E     V + + ++LC +   I  EN +V++ 
Sbjct: 1   MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCA---IVVENLLVLIA 57

Query: 69  IFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTI---GLIVASFS 125
           +  N    + M+L +G+LA +DLLAG+  + N + +  +    T +      G    + S
Sbjct: 58  VARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLS 117

Query: 126 ASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDE 185
           ASV SLLAI ++R++++     Y S+++     +++   W  S+ LG LP++GWNCL   
Sbjct: 118 ASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIGASWLISLVLGGLPILGWNCLGHL 176

Query: 186 STCSVVRPLTKNNAAILSVS-FLFMFALMLQLYIQI-CKIVMRHAHQIALQHHFLATSHY 243
             CS V PL   +  +  V+ F  +   ++ LY++I C +   HA   A Q         
Sbjct: 177 EACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQ--------- 227

Query: 244 VTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATY-------NSII 296
             T   + T+ I+LG F  CW+P     L+ DY  P +++   L  A Y       NS++
Sbjct: 228 --TLALLKTVTIVLGVFIVCWLP-AFSILLLDYACP-VHSCPILYKAHYFFAVSTLNSLL 283

Query: 297 NPVIYAFRNQEIQK 310
           NPVIY +R++++++
Sbjct: 284 NPVIYTWRSRDLRR 297


>gi|119508433 melanocortin 4 receptor [Homo sapiens]
          Length = 332

 Score =  123 bits (309), Expect = 2e-28
 Identities = 91/294 (30%), Positives = 143/294 (48%), Gaps = 34/294 (11%)

Query: 41  ELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITN 100
           +L V+P   V  T G +   EN +V++ I  N +L +PM+  I SLA+AD+L  +   + 
Sbjct: 43  QLFVSPE--VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSE 100

Query: 101 FVFAYLLQSEATKL---------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSE 151
            +   LL S  T           V   +I +S  AS+CSLL+I VDRY +++YAL YH+ 
Sbjct: 101 TIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNI 160

Query: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211
            TV    +++  +W      G+L +     +  +S+  ++          L   F  M A
Sbjct: 161 MTVKRVGIIISCIWAACTVSGILFI-----IYSDSSAVII---------CLITMFFTMLA 206

Query: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYS 271
           LM  LY+ +  +   H  +IA+              KG  TL I++G F  CW PF L+ 
Sbjct: 207 LMASLYVHMFLMARLHIKRIAVLPG-TGAIRQGANMKGAITLTILIGVFVVCWAPFFLHL 265

Query: 272 L--IADYTYPSIYTYAT-----LLPATYNSIINPVIYAFRNQEIQKALC-LICC 317
           +  I+    P    + +     L+    NSII+P+IYA R+QE++K    +ICC
Sbjct: 266 IFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICC 319


>gi|170671732 melanocortin 3 receptor [Homo sapiens]
          Length = 323

 Score =  123 bits (309), Expect = 2e-28
 Identities = 94/326 (28%), Positives = 148/326 (45%), Gaps = 48/326 (14%)

Query: 15  DYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPS 74
           ++L A    N S++       ++PE          V  + G +   EN +V+L +  N +
Sbjct: 19  EHLQAPFFSNQSSSAFCEQVFIKPE----------VFLSLGIVSLLENILVILAVVRNGN 68

Query: 75  LRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKL----------VTIGLIVASF 124
           L +PM+  + SLA+AD+L  +      +   ++ S+              +   +I  S 
Sbjct: 69  LHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISL 128

Query: 125 SASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRD 184
            AS+C+LLAI VDRY++++YAL YHS  TV     ++V +W   +C G+  V+       
Sbjct: 129 VASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIW---VCCGVCGVV------- 178

Query: 185 ESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQI-ALQHHFLATSHY 243
                +V   +K     L   F  M  LM  LY+ +      H  +I AL          
Sbjct: 179 ----FIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQ 234

Query: 244 VTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----------IYTYATLLPATYN 293
            +  KG  T+ I+LG F  CW PF L+ L+   T P+            TY  L+    N
Sbjct: 235 HSCMKGAVTITILLGVFIFCWAPFFLH-LVLIITCPTNPYCICYTAHFNTYLVLIMC--N 291

Query: 294 SIINPVIYAFRNQEIQKALCLICCGC 319
           S+I+P+IYAFR+ E++     I CGC
Sbjct: 292 SVIDPLIYAFRSLELRNTFREILCGC 317


>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
          Length = 364

 Score =  120 bits (300), Expect = 2e-27
 Identities = 84/283 (29%), Positives = 145/283 (51%), Gaps = 18/283 (6%)

Query: 58  ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIG---LITNFVFAYLLQSEATKL 114
           I   N +V++ I+ N     P++ L+ +LA AD  AG+    L+ N        + +T L
Sbjct: 63  IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL 122

Query: 115 VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLL 174
           +  GLI  S +ASV +LLAI ++R+++++  +  H+  +     V++V++W  +I +G +
Sbjct: 123 LRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAI 181

Query: 175 PVMGWNCLRDESTCSVVRPLTKNNAAILSVSF-LFMFALMLQLYIQICKIVMRHAHQIAL 233
           P +GWNC+ D   CS + PL  ++  +    F L  F +M+ LY  I   V +   +++ 
Sbjct: 182 PSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS- 240

Query: 234 QHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----IYTYATLLP 289
           +H      +  T    + T+ I+LG F  CW P  L  L+ D   P      Y    LL 
Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCDVLAYEKFFLLL 299

Query: 290 ATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPS 332
           A +NS +NP+IY++R++E+      I C        QR+ +P+
Sbjct: 300 AEFNSAMNPIIYSYRDKEMSATFRQILC-------CQRSENPT 335


>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
          Length = 364

 Score =  120 bits (300), Expect = 2e-27
 Identities = 84/283 (29%), Positives = 145/283 (51%), Gaps = 18/283 (6%)

Query: 58  ISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIG---LITNFVFAYLLQSEATKL 114
           I   N +V++ I+ N     P++ L+ +LA AD  AG+    L+ N        + +T L
Sbjct: 63  IMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWL 122

Query: 115 VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLL 174
           +  GLI  S +ASV +LLAI ++R+++++  +  H+  +     V++V++W  +I +G +
Sbjct: 123 LRQGLIDTSLTASVANLLAIAIERHITVF-RMQLHTRMSNRRVVVVIVVIWTMAIVMGAI 181

Query: 175 PVMGWNCLRDESTCSVVRPLTKNNAAILSVSF-LFMFALMLQLYIQICKIVMRHAHQIAL 233
           P +GWNC+ D   CS + PL  ++  +    F L  F +M+ LY  I   V +   +++ 
Sbjct: 182 PSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS- 240

Query: 234 QHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPS----IYTYATLLP 289
           +H      +  T    + T+ I+LG F  CW P  L  L+ D   P      Y    LL 
Sbjct: 241 RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP-GLVLLLLDVCCPQCDVLAYEKFFLLL 299

Query: 290 ATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPS 332
           A +NS +NP+IY++R++E+      I C        QR+ +P+
Sbjct: 300 AEFNSAMNPIIYSYRDKEMSATFRQILC-------CQRSENPT 335


>gi|5174535 melanocortin 5 receptor [Homo sapiens]
          Length = 325

 Score =  118 bits (296), Expect = 6e-27
 Identities = 84/286 (29%), Positives = 143/286 (50%), Gaps = 33/286 (11%)

Query: 50  VLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQS 109
           V  T G +   EN +V+  I  N +L +PM+  + SLA+AD+L  +      +  YLL +
Sbjct: 42  VFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNN 101

Query: 110 EATKL----------VTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYV 159
           +   +          V   +I  S  AS+CSLLAI VDRY++++YAL YH   T   +  
Sbjct: 102 KHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGA 161

Query: 160 MLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQ 219
           ++  +W      G++ +     L  EST  ++         ++S+ F  +F L++ LYI 
Sbjct: 162 IIAGIWAFCTGCGIVFI-----LYSESTYVIL--------CLISMFFAMLF-LLVSLYIH 207

Query: 220 ICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYP 279
           +  +   H  +IA      +++   T+ +G  T+ ++LG F  CW PF L+  +      
Sbjct: 208 MFLLARTHVKRIAALPG-ASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQ 266

Query: 280 SIYT-------YATLLPATYNSIINPVIYAFRNQEIQKALC-LICC 317
           ++Y           L+    NS+++P+IYAFR+QE++K    +ICC
Sbjct: 267 NLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICC 312


>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
          Length = 378

 Score =  118 bits (295), Expect = 8e-27
 Identities = 83/289 (28%), Positives = 141/289 (48%), Gaps = 19/289 (6%)

Query: 49  IVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA---Y 105
           +V+C+    I  EN +V++ I+ N      M+  IG+LAL DLLAGI    N + +    
Sbjct: 47  LVICS---FIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKT 103

Query: 106 LLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLW 165
              S     +  G +  +  AS CSLLAI ++R+L++     Y + +     ++++ M W
Sbjct: 104 FSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHR-VFLLIGMCW 162

Query: 166 GTSICLGLLPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIV 224
             +  LG LP++GWNCL +   CS + PL +K   A     F  +   ++ LY +I  +V
Sbjct: 163 LIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLV 222

Query: 225 MRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLI----ADYTYPS 280
              + ++A  H+    S  +     + T+ I++  F ACW P  +  LI         P 
Sbjct: 223 KSSSRKVA-NHNNSERSMAL-----LRTVVIVVSVFIACWSPLFILFLIDVACRVQACPI 276

Query: 281 IY-TYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRA 328
           ++     ++ A  NS +NPVIY   ++E+++A   + C C+      RA
Sbjct: 277 LFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARA 325


>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403

Query: 308 IQKA 311
           ++ A
Sbjct: 404 LRHA 407


>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403

Query: 308 IQKA 311
           ++ A
Sbjct: 404 LRHA 407


>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403

Query: 308 IQKA 311
           ++ A
Sbjct: 404 LRHA 407


>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403

Query: 308 IQKA 311
           ++ A
Sbjct: 404 LRHA 407


>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
          Length = 472

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 109 MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 168

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 169 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 228

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 229 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 288

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 289 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 344

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 345 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 403

Query: 308 IQKA 311
           ++ A
Sbjct: 404 LRHA 407


>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
          Length = 439

 Score =  115 bits (287), Expect = 7e-26
 Identities = 82/304 (26%), Positives = 146/304 (48%), Gaps = 39/304 (12%)

Query: 42  LVVNPWD-----IVLCTSGTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGI 95
           +V+NP       ++  T GT    EN +V+ +I H+ SLR  P +  IGSLA+ADLL  +
Sbjct: 76  MVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSV 135

Query: 96  GLITNFVFAYLLQSEATK---LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSER 152
             + +F+  ++   + ++   L  +G + ASF+ASV SL    +DRY+S++  L Y    
Sbjct: 136 IFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIV 195

Query: 153 TVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSV---SFLFM 209
           T     V   ++W  +I + +LP++GWNC + +S CS + P       +  +   S L +
Sbjct: 196 TRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLL 255

Query: 210 FALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKG-----------------VST 252
           F +   +YI    +   H+H + +       S  + T +                    T
Sbjct: 256 FIVYAYMYI----LWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKT 311

Query: 253 LAIILGTFAACWMP---FTLYSLIA--DYTYPSIYTYATLLPATYNSIINPVIYAFRNQE 307
           L +IL     CW P     +Y +    +    +++ + ++L    NS +NP+IYA R+++
Sbjct: 312 LVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML-CLLNSTVNPIIYALRSKD 370

Query: 308 IQKA 311
           ++ A
Sbjct: 371 LRHA 374


>gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]
          Length = 360

 Score =  112 bits (280), Expect = 5e-25
 Identities = 88/278 (31%), Positives = 139/278 (50%), Gaps = 22/278 (7%)

Query: 50  VLCTS-GTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGIGLITNFVFAYL- 106
           VLCT  G L + EN  V+ +I  +  LR  P +L IGSLA AD LA +    +FV  ++ 
Sbjct: 38  VLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97

Query: 107 --LQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVML 164
             + S+A  L+ IG +  +F+ASV SLL   +DRYL L Y  +Y +  T     V L ++
Sbjct: 98  HGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIM 157

Query: 165 WGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFL-FMFALMLQLYIQICKI 223
           W  S  +  LP+MGW C      CS + PL  N+  +  + F+ F+F+ ++  Y  +  +
Sbjct: 158 WVLSALVSYLPLMGWTCC--PRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHV--L 213

Query: 224 VMRHAHQIALQHH----FLATSHYVTTRKGVSTLAIILGTFAACWMP------FTLYSLI 273
              H H  +L  H        +      +   TL ++L     CW P       +L + +
Sbjct: 214 WKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTL 273

Query: 274 ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKA 311
           +D      + + ++L    NS++NPVIYA R+ EI+ +
Sbjct: 274 SDQV-KKAFAFCSML-CLINSMVNPVIYALRSGEIRSS 309


>gi|193083134 melanocortin 1 receptor [Homo sapiens]
          Length = 317

 Score =  108 bits (270), Expect = 7e-24
 Identities = 93/288 (32%), Positives = 137/288 (47%), Gaps = 31/288 (10%)

Query: 42  LVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLL-AGIGLITN 100
           L V+  D +  + G +   ENA+VV  I  N +L +PM+  I  LAL+DLL +G  ++  
Sbjct: 36  LEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLET 95

Query: 101 FVFAYL----LQSEATKLVTIGLIV-----ASFSASVCSLLAITVDRYLSLYYALTYHSE 151
            V   L    L + A  L  +  ++     +S  +S+C L AI VDRY+S++YAL YHS 
Sbjct: 96  AVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSI 155

Query: 152 RTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFA 211
            T+      +  +W  S+    L +  ++ +                   L V FL M  
Sbjct: 156 VTLPRARRAVAAIWVASVVFSTLFIAYYDHVAV--------------LLCLVVFFLAMLV 201

Query: 212 LMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPF---- 267
           LM  LY+ +     +HA  IA  H      H     KG  TL I+LG F  CW PF    
Sbjct: 202 LMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHL 261

Query: 268 TLYSLIADY-TYPSIYTYATLLPATY--NSIINPVIYAFRNQEIQKAL 312
           TL  L  ++ T   I+    L  A    N+II+P+IYAF +QE+++ L
Sbjct: 262 TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTL 309


>gi|4505127 melanocortin 2 receptor [Homo sapiens]
          Length = 297

 Score =  105 bits (261), Expect = 7e-23
 Identities = 78/269 (28%), Positives = 126/269 (46%), Gaps = 41/269 (15%)

Query: 61  ENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL-----------LQS 109
           EN IV+L +F N +L+APM+  I SLA++D+L  +  I   +   L            ++
Sbjct: 41  ENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFET 100

Query: 110 EATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSI 169
            A  ++   L V S   S+ SL  I  DRY+++++AL YHS  T+  T V+L ++W    
Sbjct: 101 TADDIID-SLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCT 159

Query: 170 CLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAH 229
             G+  V+  + +    T + + PL              M   +L LY+ +  +   H  
Sbjct: 160 GTGITMVIFSHHVPTVITFTSLFPL--------------MLVFILCLYVHMFLLARSHTR 205

Query: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADY--TYPSIYTYATL 287
           +I+               KG  TL I+LG F  CW PF L+ L+  +  + P    Y +L
Sbjct: 206 KISTLPR--------ANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSL 257

Query: 288 LPAT-----YNSIINPVIYAFRNQEIQKA 311
                     N++I+P IYAFR+ E++ A
Sbjct: 258 FQVNGMLIMCNAVIDPFIYAFRSPELRDA 286


>gi|4501953 adenosine A3 receptor isoform 2 [Homo sapiens]
          Length = 318

 Score =  100 bits (250), Expect = 1e-21
 Identities = 70/273 (25%), Positives = 134/273 (49%), Gaps = 15/273 (5%)

Query: 62  NAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYL---LQSEATKLVTIG 118
           N +V+ ++  NPSL+   F  I SLALAD+  G+ ++   +   L   +   +   +T  
Sbjct: 30  NVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCL 89

Query: 119 LIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMG 178
           L++ +  AS+ SLLAI VDRYL +   + Y    T    ++ L + W  S  +GL P+ G
Sbjct: 90  LLIFTH-ASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFG 148

Query: 179 WNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQI---CKI------VMRHAH 229
           WN          V  L+    +++ + ++  F+ +  ++I +   C I      ++R+  
Sbjct: 149 WNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKL 208

Query: 230 QIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYT--YPSIYTYATL 287
            + L +     + Y    K   +L ++L  FA  W+P ++ + I  +    P +  Y  +
Sbjct: 209 SLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGI 268

Query: 288 LPATYNSIINPVIYAFRNQEIQKALCLICCGCI 320
           L +  NS++NP++YA++ ++ ++   LI   C+
Sbjct: 269 LLSHANSMMNPIVYAYKIKKFKETYLLILKACV 301


>gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo
           sapiens]
          Length = 384

 Score = 95.5 bits (236), Expect = 6e-20
 Identities = 75/289 (25%), Positives = 132/289 (45%), Gaps = 23/289 (7%)

Query: 57  LISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFA---YLLQSEATK 113
           L+  EN +V+  I  +   R  ++  + ++ L+DLL G   + N + +       + A  
Sbjct: 59  LVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQW 118

Query: 114 LVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGL 173
            +  GL+  + +AS  SLL    +R+ ++   +        +  Y  + + W  +  LG+
Sbjct: 119 FLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGM 178

Query: 174 LPVMGWNCLRDESTCSVVRPL-TKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIA 232
           LP++GWNCL     CS + PL +K       V F  + A ++ LY  I ++V     +  
Sbjct: 179 LPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAP 238

Query: 233 LQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYA------- 285
                   +     R+ + T+ +IL  F  CW P     L+AD    +++          
Sbjct: 239 ------RPAARRKARRLLKTVLMILLAFLVCWGPL-FGLLLADVFGSNLWAQEYLRGMDW 291

Query: 286 TLLPATYNSIINPVIYAFRNQEIQKA-LCLICCGCIPSSLAQRARSPSD 333
            L  A  NS +NP+IY+FR++E+ +A L  +CCGC+   +    R P D
Sbjct: 292 ILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGM----RGPGD 336


>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
          Length = 359

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%)

Query: 83  IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137
           I SLA ADLL  + L+  F    L+Q      E   LV   L V   +AS+  L  I++D
Sbjct: 59  IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117

Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183
           RY ++    L Y ++ T     +ML   W     +  LP+M GWN +            +
Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177

Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241
           + ++   V  + K  A   SV +F   F LM+  Y +I      HAHQI +     A+S 
Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237

Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286
                      H + T  K   TL II+G F  CW PF + +++    DYT P     A 
Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297

Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317
           L     NS +NP +YAF N+  ++A  +I C
Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328


>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
          Length = 428

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%)

Query: 83  IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137
           I SLA ADLL  + L+  F    L+Q      E   LV   L V   +AS+  L  I++D
Sbjct: 59  IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117

Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183
           RY ++    L Y ++ T     +ML   W     +  LP+M GWN +            +
Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177

Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241
           + ++   V  + K  A   SV +F   F LM+  Y +I      HAHQI +     A+S 
Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237

Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286
                      H + T  K   TL II+G F  CW PF + +++    DYT P     A 
Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297

Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317
           L     NS +NP +YAF N+  ++A  +I C
Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328


>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
          Length = 360

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%)

Query: 83  IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137
           I SLA ADLL  + L+  F    L+Q      E   LV   L V   +AS+  L  I++D
Sbjct: 59  IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117

Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183
           RY ++    L Y ++ T     +ML   W     +  LP+M GWN +            +
Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177

Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241
           + ++   V  + K  A   SV +F   F LM+  Y +I      HAHQI +     A+S 
Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237

Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286
                      H + T  K   TL II+G F  CW PF + +++    DYT P     A 
Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297

Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317
           L     NS +NP +YAF N+  ++A  +I C
Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328


>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
          Length = 387

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%)

Query: 83  IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137
           I SLA ADLL  + L+  F    L+Q      E   LV   L V   +AS+  L  I++D
Sbjct: 59  IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117

Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183
           RY ++    L Y ++ T     +ML   W     +  LP+M GWN +            +
Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177

Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241
           + ++   V  + K  A   SV +F   F LM+  Y +I      HAHQI +     A+S 
Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237

Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286
                      H + T  K   TL II+G F  CW PF + +++    DYT P     A 
Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297

Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317
           L     NS +NP +YAF N+  ++A  +I C
Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328


>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
          Length = 378

 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 84/271 (30%), Positives = 121/271 (44%), Gaps = 37/271 (13%)

Query: 83  IGSLALADLLAGIGLITNFVFAYLLQS-----EATKLVTIGLIVASFSASVCSLLAITVD 137
           I SLA ADLL  + L+  F    L+Q      E   LV   L V   +AS+  L  I++D
Sbjct: 59  IVSLAFADLLVSV-LVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLD 117

Query: 138 RYLSLY-YALTYHSERTVTFTYVMLVMLWGTSICLGLLPVM-GWNCL------------R 183
           RY ++    L Y ++ T     +ML   W     +  LP+M GWN +            +
Sbjct: 118 RYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQ 177

Query: 184 DESTCSVVRPLTKNNAAILSV-SFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATS- 241
           + ++   V  + K  A   SV +F   F LM+  Y +I      HAHQI +     A+S 
Sbjct: 178 NSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSE 237

Query: 242 -----------HYVTTR-KGVSTLAIILGTFAACWMPFTLYSLI---ADYTYPSIYTYAT 286
                      H + T  K   TL II+G F  CW PF + +++    DYT P     A 
Sbjct: 238 SRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAF 297

Query: 287 LLPATYNSIINPVIYAFRNQEIQKALCLICC 317
           L     NS +NP +YAF N+  ++A  +I C
Sbjct: 298 LWLGYINSGLNPFLYAFLNKSFRRAFLIILC 328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,155,623
Number of Sequences: 37866
Number of extensions: 440493
Number of successful extensions: 2897
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 278
Number of HSP's successfully gapped in prelim test: 380
Number of HSP's that attempted gapping in prelim test: 1812
Number of HSP's gapped (non-prelim): 895
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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