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Search of human proteins with 48762926
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48762926 PWP2 periodic tryptophan protein homolog [Homo
sapiens]
(919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens] 1860 0.0
gi|21071067 TBP-associated factor 5 [Homo sapiens] 102 2e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 99 2e-20
gi|16554629 WD repeat domain 5 [Homo sapiens] 97 5e-20
gi|16554627 WD repeat domain 5 [Homo sapiens] 97 5e-20
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 96 2e-19
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 94 4e-19
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 94 8e-19
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 94 8e-19
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 93 1e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 93 1e-18
gi|23199987 WD repeat domain 5B [Homo sapiens] 93 1e-18
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 92 2e-18
gi|113865883 WD repeat domain 38 [Homo sapiens] 92 3e-18
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 89 1e-17
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 89 2e-17
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 87 5e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 87 5e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 87 5e-17
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 87 7e-17
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 82 2e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 81 4e-15
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 81 4e-15
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 79 1e-14
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 79 2e-14
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 79 3e-14
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 77 6e-14
gi|26665869 WD repeat domain 51B [Homo sapiens] 77 6e-14
gi|19913367 transducin beta-like 1Y [Homo sapiens] 76 1e-13
gi|19913365 transducin beta-like 1Y [Homo sapiens] 76 1e-13
>gi|48762926 PWP2 periodic tryptophan protein homolog [Homo sapiens]
Length = 919
Score = 1860 bits (4817), Expect = 0.0
Identities = 919/919 (100%), Positives = 919/919 (100%)
Query: 1 MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKC 60
MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKC
Sbjct: 1 MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKC 60
Query: 61 VGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQ 120
VGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQ
Sbjct: 61 VGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQ 120
Query: 121 MYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLI 180
MYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLI
Sbjct: 121 MYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLI 180
Query: 181 YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRE 240
YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRE
Sbjct: 181 YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRE 240
Query: 241 EEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKS 300
EEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKS
Sbjct: 241 EEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKS 300
Query: 301 HLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEW 360
HLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEW
Sbjct: 301 HLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEW 360
Query: 361 QSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG 420
QSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG
Sbjct: 361 QSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG 420
Query: 421 VTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDS 480
VTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDS
Sbjct: 421 VTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDS 480
Query: 481 FEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETL 540
FEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETL
Sbjct: 481 FEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETL 540
Query: 541 ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAK 600
ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAK
Sbjct: 541 ALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAK 600
Query: 601 HAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNR 660
HAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNR
Sbjct: 601 HAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNR 660
Query: 661 RKMTEFGNLALIDQDAGQEDGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAAT 720
RKMTEFGNLALIDQDAGQEDGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAAT
Sbjct: 661 RKMTEFGNLALIDQDAGQEDGVAIPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAAT 720
Query: 721 TTEGLLIYSLDTRVLFDPFELDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALE 780
TTEGLLIYSLDTRVLFDPFELDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALE
Sbjct: 721 TTEGLLIYSLDTRVLFDPFELDTSVTPGRVREALRQQDFTRAILMALRLNESKLVQEALE 780
Query: 781 AVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQKLKSRAGT 840
AVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQKLKSRAGT
Sbjct: 781 AVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSRHLEFYLLWTHKLLMLHGQKLKSRAGT 840
Query: 841 LLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVSKQRGTKRSLDPLGSEEEAEASED 900
LLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVSKQRGTKRSLDPLGSEEEAEASED
Sbjct: 841 LLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVSKQRGTKRSLDPLGSEEEAEASED 900
Query: 901 DSLHLLGGGGRDSEEEMLA 919
DSLHLLGGGGRDSEEEMLA
Sbjct: 901 DSLHLLGGGGRDSEEEMLA 919
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 102 bits (254), Expect = 2e-21
Identities = 73/297 (24%), Positives = 126/297 (42%), Gaps = 14/297 (4%)
Query: 281 FFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINS 340
F+ + LTA S L+ GFA + + L SD S+ I+
Sbjct: 463 FYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSL----IDK 518
Query: 341 SGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVW 400
D + L +++ + SE +L GH + ++SPD Y+++ +DG V++W
Sbjct: 519 ESDDV------LERIMDEKTASELKIL--YGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570
Query: 401 NTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQ 460
+ + C V + H+ V F+ GY V+ D R + Y+ R F
Sbjct: 571 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAG-HLAD 629
Query: 461 FSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASAS 520
+C + V+ G+ D + +W + G + + +GH+GPI L F+P LA+ +
Sbjct: 630 VNCTRFHPNSNYVATGSADR-TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688
Query: 521 WDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQ 577
D V LWD+ E T ++ F DG LA ++++ + WD A +
Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745
Score = 87.0 bits (214), Expect = 7e-17
Identities = 60/216 (27%), Positives = 96/216 (44%), Gaps = 2/216 (0%)
Query: 353 GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFT 412
G + +W Q+ + ++ +GH + +SP G Y V+GG D ++W T F
Sbjct: 565 GTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFA 624
Query: 413 EHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEI 472
H + V F V T S D TVR +D+ R FT + S + +G
Sbjct: 625 GHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHS-LTFSPNGRF 683
Query: 473 VSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFD 532
++ GA D + +W + G ++ L GH + L F+ +LAS S D TVRLWD
Sbjct: 684 LATGATDG-RVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Query: 533 SWRTKETLALTSDALAVTFRPDGAELAVATLNSQIT 568
++ ET T+ + + EL + T ++ T
Sbjct: 743 AFEDLETDDFTTATGHINLPENSQELLLGTYMTKST 778
Score = 55.5 bits (132), Expect = 2e-07
Identities = 37/128 (28%), Positives = 55/128 (42%), Gaps = 13/128 (10%)
Query: 403 LSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFS 462
L CF TF G+T V T ++ D TVR + S P +
Sbjct: 458 LPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVW------------SVTPKKLR 505
Query: 463 CVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWD 522
V + ++ + D E + +T L +L GH GP+ G F+P ++ L S+S D
Sbjct: 506 SVKQASDLSLIDKESDDVLE-RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSED 564
Query: 523 KTVRLWDM 530
TVRLW +
Sbjct: 565 GTVRLWSL 572
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 99.0 bits (245), Expect = 2e-20
Identities = 70/262 (26%), Positives = 116/262 (44%), Gaps = 3/262 (1%)
Query: 267 EKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSL 326
+KT K+ K + G + +F+ +S L+ TG L ++ +++L
Sbjct: 156 DKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 327 SISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQ 386
I S++ N+SGD I G S ++VW+ + V GH + + +++ D
Sbjct: 216 RGHSAEIISLSFNTSGDRIITG-SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 387 YIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHR 446
I+TG D K+W+ +G C T T H + F TG ++ T+S DGT R F
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA-A 333
Query: 447 YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISG 506
R + S ++ + G + G+ D +W QTG+ L VL GH I
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK-TARIWDAQTGQCLQVLEGHTDEIFS 392
Query: 507 LCFNPMKSVLASASWDKTVRLW 528
FN +++ + S D T R+W
Sbjct: 393 CAFNYKGNIVITGSKDNTCRIW 414
Score = 95.9 bits (237), Expect = 2e-19
Identities = 63/211 (29%), Positives = 102/211 (48%), Gaps = 4/211 (1%)
Query: 320 FNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVAL 379
F L L + +VA+N SG G S +W+ S + +GH N + A+
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITG-SYDRTCKLWDTASGEELNTLEGHRNVVYAI 140
Query: 380 AYS-PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGT 438
A++ P G I TG D K+W+ +G C+ TF H++ + ++F +V T SMD T
Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200
Query: 439 VRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLS 498
+ +D+ T + ++ + SG+ + G+ D + VW TGR +++L
Sbjct: 201 AKLWDIQNGEEVYTLRG-HSAEIISLSFNTSGDRIITGSFD-HTVVVWDADTGRKVNILI 258
Query: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWD 529
GH IS FN S++ + S DKT +LWD
Sbjct: 259 GHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
Score = 77.4 bits (189), Expect = 6e-14
Identities = 59/256 (23%), Positives = 107/256 (41%), Gaps = 8/256 (3%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTAT-GY 428
+ H + +A + G +TG D K+W+T SG T H + V + F G
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 429 VVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSM 488
+ T S D T + + + + + TF + C++ + +V+ G+ D+ +W +
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRG-HTAEIVCLSFNPQSTLVATGSMDT-TAKLWDI 206
Query: 489 QTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALA 548
Q G + L GH I L FN + + S+D TV +WD + + ++ +
Sbjct: 207 QNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISS 266
Query: 549 VTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHD--LKTGRKELDKITAKHAAKGK 606
+F D + + +++ WD N ++ G D L + K+ A +A G
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG- 325
Query: 607 AFTALCYSADGHSILA 622
TA +SA +A
Sbjct: 326 --TARIFSAATRKCIA 339
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/222 (22%), Positives = 91/222 (40%), Gaps = 21/222 (9%)
Query: 406 FCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVA 465
+ F H +T V +G +T S D T + +D T R ++
Sbjct: 83 YLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF 142
Query: 466 VDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTV 525
+ G+ ++ G+ D +WS++TG+ GH I L FNP +++A+ S D T
Sbjct: 143 NNPYGDKIATGSFDK-TCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTA 201
Query: 526 RLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRH 585
+LWD+ + +++ ++++F G + + + + WD +
Sbjct: 202 KLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDAD------------ 249
Query: 586 DLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSK 627
TGRK I H A+ ++ ++ D IL G M K
Sbjct: 250 ---TGRKV--NILIGHCAE---ISSASFNWDCSLILTGSMDK 283
Score = 64.7 bits (156), Expect = 4e-10
Identities = 55/260 (21%), Positives = 103/260 (39%), Gaps = 17/260 (6%)
Query: 181 YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRE 240
Y+ GH IV F S + + S D +W E L+ G A+++
Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR---GHSAEIISLS 226
Query: 241 EEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKS 300
+ G + T+ + TG+ K + L G +++A+F+
Sbjct: 227 FNTSGDRIITGSFDHTV-----VVWDADTGR-KVNILI-------GHCAEISSASFNWDC 273
Query: 301 HLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEW 360
L++TG L + + +L+ D I + +G IA S G ++
Sbjct: 274 SLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATA-SADGTARIFSA 332
Query: 361 QSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG 420
+ + K +GH + ++++P G +++TG D ++W+ +G C H+ +
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFS 392
Query: 421 VTFTATGYVVVTSSMDGTVR 440
F G +V+T S D T R
Sbjct: 393 CAFNYKGNIVITGSKDNTCR 412
Score = 35.8 bits (81), Expect = 0.19
Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 1/88 (1%)
Query: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
S T L VL H P++ + N S + S+D+T +LWD +
Sbjct: 78 SNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVV 137
Query: 547 LAVTF-RPDGAELAVATLNSQITFWDPE 573
A+ F P G ++A + + W E
Sbjct: 138 YAIAFNNPYGDKIATGSFDKTCKLWSVE 165
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.4 bits (241), Expect = 5e-20
Identities = 57/211 (27%), Positives = 106/211 (50%), Gaps = 5/211 (2%)
Query: 364 SYVLK--QQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGV 421
+Y LK GH ++ ++ +SP+G+++ + D +K+W G T + H G++ V
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 422 TFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSF 481
+++ ++V++S D T++ +D+ + +T F C S IVS +S
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 482 EIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLA 541
I W ++TG+ L L H P+S + FN S++ S+S+D R+WD K +
Sbjct: 154 RI--WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 542 LTSDALA-VTFRPDGAELAVATLNSQITFWD 571
+ ++ V F P+G + ATL++ + WD
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 84.7 bits (208), Expect = 4e-16
Identities = 72/335 (21%), Positives = 141/335 (42%), Gaps = 56/335 (16%)
Query: 242 EEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSH 301
EE++ E + + T AT + K VK + K F G +++ F
Sbjct: 4 EEKKPETEAARAQPTPSSSAT---QSKPTPVKPNYALK--FTLAGHTKAVSSVKFSPNGE 58
Query: 302 LLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQ 361
L + A + + + ++S I+ VA +S + + S L +W+
Sbjct: 59 WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVS 117
Query: 362 SESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGV 421
S + +GH N + ++P IV+G D V++W+ +G C T HS V+ V
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Query: 422 TFTATGYVVVTSSMDG-------------------------------------------T 438
F G ++V+SS DG T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 439 VRAFDLHRYRNFRTFTSPRPTQFSCVAVDAS---GEIVSAGAQDSFEIFVWSMQTGRLLD 495
++ +D + + +T+T + ++ C+ + S G+ + +G++D+ +++W++QT ++
Sbjct: 238 LKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQ 295
Query: 496 VLSGHEGPISGLCFNPMKSVLASASW--DKTVRLW 528
L GH + +P ++++ASA+ DKT++LW
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 38.9 bits (89), Expect = 0.022
Identities = 57/307 (18%), Positives = 116/307 (37%), Gaps = 23/307 (7%)
Query: 134 FVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVA 193
+ L T G + + ++ + S D ++GA +D + GHK I
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISD 92
Query: 194 CFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDR 253
+ S+S L S S D L +W + G LK G + + G
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSS---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 254 ETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFH 313
+ ++R + KTGK + A + ++A F++ L+V+ G+
Sbjct: 150 DESVR-----IWDVKTGKCLKTLPA--------HSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 314 LHELPEFNLIHSLSISDQ-SIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGH 372
+ + + +L D ++ V + +G +I + L +W++ + GH
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 373 FNSMVALAYS---PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
N + + G++IV+G +D V +WN + H+ V T +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 430 VVTSSMD 436
+ +++++
Sbjct: 316 IASAALE 322
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 97.4 bits (241), Expect = 5e-20
Identities = 57/211 (27%), Positives = 106/211 (50%), Gaps = 5/211 (2%)
Query: 364 SYVLK--QQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGV 421
+Y LK GH ++ ++ +SP+G+++ + D +K+W G T + H G++ V
Sbjct: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 422 TFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSF 481
+++ ++V++S D T++ +D+ + +T F C S IVS +S
Sbjct: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
Query: 482 EIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLA 541
I W ++TG+ L L H P+S + FN S++ S+S+D R+WD K +
Sbjct: 154 RI--WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 542 LTSDALA-VTFRPDGAELAVATLNSQITFWD 571
+ ++ V F P+G + ATL++ + WD
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 84.7 bits (208), Expect = 4e-16
Identities = 72/335 (21%), Positives = 141/335 (42%), Gaps = 56/335 (16%)
Query: 242 EEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSH 301
EE++ E + + T AT + K VK + K F G +++ F
Sbjct: 4 EEKKPETEAARAQPTPSSSAT---QSKPTPVKPNYALK--FTLAGHTKAVSSVKFSPNGE 58
Query: 302 LLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQ 361
L + A + + + ++S I+ VA +S + + S L +W+
Sbjct: 59 WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV-SASDDKTLKIWDVS 117
Query: 362 SESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGV 421
S + +GH N + ++P IV+G D V++W+ +G C T HS V+ V
Sbjct: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAV 177
Query: 422 TFTATGYVVVTSSMDG-------------------------------------------T 438
F G ++V+SS DG T
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
Query: 439 VRAFDLHRYRNFRTFTSPRPTQFSCVAVDAS---GEIVSAGAQDSFEIFVWSMQTGRLLD 495
++ +D + + +T+T + ++ C+ + S G+ + +G++D+ +++W++QT ++
Sbjct: 238 LKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQ 295
Query: 496 VLSGHEGPISGLCFNPMKSVLASASW--DKTVRLW 528
L GH + +P ++++ASA+ DKT++LW
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 38.9 bits (89), Expect = 0.022
Identities = 57/307 (18%), Positives = 116/307 (37%), Gaps = 23/307 (7%)
Query: 134 FVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVA 193
+ L T G + + ++ + S D ++GA +D + GHK I
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--YDGKFEKTISGHKLGISD 92
Query: 194 CFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDR 253
+ S+S L S S D L +W + G LK G + + G
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSS---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 254 ETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFH 313
+ ++R + KTGK + A + ++A F++ L+V+ G+
Sbjct: 150 DESVR-----IWDVKTGKCLKTLPA--------HSDPVSAVHFNRDGSLIVSSSYDGLCR 196
Query: 314 LHELPEFNLIHSLSISDQ-SIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGH 372
+ + + +L D ++ V + +G +I + L +W++ + GH
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI-LAATLDNTLKLWDYSKGKCLKTYTGH 255
Query: 373 FNSMVALAYS---PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
N + + G++IV+G +D V +WN + H+ V T +
Sbjct: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 430 VVTSSMD 436
+ +++++
Sbjct: 316 IASAALE 322
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 95.5 bits (236), Expect = 2e-19
Identities = 66/251 (26%), Positives = 110/251 (43%), Gaps = 10/251 (3%)
Query: 286 GDFNNLTAAAFHKKSHL--------LVTGFASGIFHLHELPEFNLIHSLSISDQSIASVA 337
G N+ A FH KS + L + A G L L + + +A V
Sbjct: 271 GHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 330
Query: 338 INSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKV 397
+ SG ++ C L W+ +++ +L Q+GH + +A+ DG TGG D
Sbjct: 331 WHPSGRFLGTTCYDRSWRL-WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFG 389
Query: 398 KVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR 457
+VW+ +G C + H + G+ F+ GY + T S D T + +DL + R T + +
Sbjct: 390 RVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449
Query: 458 PTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLA 517
G + GA D+ +W+ L L+GHEG + GL + ++A
Sbjct: 450 NLVTGVKFEPIHGNFLLTGAYDN-TAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
Query: 518 SASWDKTVRLW 528
+ S+D+T +LW
Sbjct: 509 TCSYDRTFKLW 519
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/258 (23%), Positives = 101/258 (39%), Gaps = 37/258 (14%)
Query: 273 KYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQS 332
K R F ++ GD ++ F S +L T SG+ L +P+ NL+H+L + +
Sbjct: 216 KSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTN 275
Query: 333 IASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGG 392
+ ++ H S V+L P + +
Sbjct: 276 VGAIVF---------------------------------HPKSTVSL--DPKDVNLASCA 300
Query: 393 DDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRT 452
DG VK+W+ S H+ V V + +G + T+ D + R +DL
Sbjct: 301 ADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILH 360
Query: 453 FTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPM 512
+ +A G + G D+F VW ++TGR + L GH I G+ F+P
Sbjct: 361 QEGHSMGVYD-IAFHQDGSLAGTGGLDAFGR-VWDLRTGRCIMFLEGHLKEIYGINFSPN 418
Query: 513 KSVLASASWDKTVRLWDM 530
+A+ S D T ++WD+
Sbjct: 419 GYHIATGSGDNTCKVWDL 436
Score = 38.5 bits (88), Expect = 0.029
Identities = 25/97 (25%), Positives = 38/97 (39%), Gaps = 8/97 (8%)
Query: 485 VWSMQTGRLLDVLSGHEGPISGLCFNPMKSV--------LASASWDKTVRLWDMFDSWRT 536
+WS+ LL L GH + + F+P +V LAS + D +V+LW +
Sbjct: 257 LWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPV 316
Query: 537 KETLALTSDALAVTFRPDGAELAVATLNSQITFWDPE 573
+ T V + P G L + WD E
Sbjct: 317 ADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Score = 35.0 bits (79), Expect = 0.32
Identities = 24/101 (23%), Positives = 39/101 (38%), Gaps = 9/101 (8%)
Query: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG--- 555
G + PIS F+P +LA+A W +LW + D ++ A+ F P
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 556 -----AELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGR 591
LA + + W ++ IEG H ++ R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEG-HTVRVAR 328
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 94.4 bits (233), Expect = 4e-19
Identities = 52/181 (28%), Positives = 84/181 (46%), Gaps = 2/181 (1%)
Query: 350 SGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
SG +W+ ++ + GH +++L+ +PDG+ V+G D +K+W+ C
Sbjct: 161 SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQ 220
Query: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR-PTQFSCVAVDA 468
TF H S + V F GY T S D T R FDL + ++ + VA
Sbjct: 221 TFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSR 280
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
SG ++ AG D F +W G VL+GH+ +S L +A+ SWD +++W
Sbjct: 281 SGRLLLAG-YDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Query: 529 D 529
+
Sbjct: 340 N 340
Score = 67.8 bits (164), Expect = 4e-11
Identities = 59/257 (22%), Positives = 103/257 (40%), Gaps = 23/257 (8%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + A+ + D + +V+ DGK+ +W++ + SS V + +G
Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
Query: 430 VVTSSMDGTVRAFDLH-RYRNFRTFTS-PRPTQF-SCVAVDASGEIVSAGAQDSFEIFVW 486
V +D + L R N R P T + SC +I+++ + + W
Sbjct: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCAL--W 169
Query: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
++TG+ +GH G + L P S + D +++LWD+ DS + + SD
Sbjct: 170 DIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDI 229
Query: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGK 606
AV F P+G A TGS + L R + + + H
Sbjct: 230 NAVAFFPNG------------------YAFTTGSDDATCRLFDLRADQELLMYSHDNIIC 271
Query: 607 AFTALCYSADGHSILAG 623
T++ +S G +LAG
Sbjct: 272 GITSVAFSRSGRLLLAG 288
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 93.6 bits (231), Expect = 8e-19
Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 6/193 (3%)
Query: 340 SSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPD--GQYIVTGGDDGKV 397
++ D SG G +W+ +S + GH ++ L +P G V+GG D K
Sbjct: 162 TNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKA 221
Query: 398 KVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR 457
VW+ SG C F H S + V + +G + S D T R +DL R + S
Sbjct: 222 MVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKE 280
Query: 458 PTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSV 515
F +VD SG ++ AG D + I VW + G + +L GHE +S L +P +
Sbjct: 281 SIIFGASSVDFSLSGRLLFAGYND-YTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTA 339
Query: 516 LASASWDKTVRLW 528
S SWD T+R+W
Sbjct: 340 FCSGSWDHTLRVW 352
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/233 (24%), Positives = 99/233 (42%), Gaps = 20/233 (8%)
Query: 353 GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVW------NTLSGF 406
G+++VW+ + + ++A AY+P G I GG D K V+ N
Sbjct: 85 GKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAA 144
Query: 407 CFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCV-- 464
+ H++ ++ +FT + ++T+S DGT +D+ + ++F C+
Sbjct: 145 KKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG-HGADVLCLDL 203
Query: 465 AVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKT 524
A +G +G D + VW M++G+ + HE I+ + + P AS S D T
Sbjct: 204 APSETGNTFVSGGCDK-KAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 262
Query: 525 VRLWDMFDSWRTKETLALTS------DALAVTFRPDGAELAVATLNSQITFWD 571
RL+D+ R +A+ S A +V F G L + I WD
Sbjct: 263 CRLYDL----RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 311
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/215 (20%), Positives = 86/215 (40%), Gaps = 20/215 (9%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHS-----SGVTGVTFT 424
+GH N ++ + + D + IV+ DGKV VW++ F T EH+ + V +
Sbjct: 60 KGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDS-----FTTNKEHAVTMPCTWVMACAYA 114
Query: 425 ATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQF------SCVAVDASGEIVSAGAQ 478
+G + +D + L +N + +C ++ +I++A
Sbjct: 115 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 174
Query: 479 DSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK--SVLASASWDKTVRLWDMFDSWRT 536
+ + W +++G+LL GH + L P + + S DK +WDM
Sbjct: 175 GTCAL--WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 232
Query: 537 KETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ SD +V + P G A + ++ +D
Sbjct: 233 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
Score = 39.7 bits (91), Expect = 0.013
Identities = 63/311 (20%), Positives = 108/311 (34%), Gaps = 63/311 (20%)
Query: 138 KTYFGPYDETTCIDWTDDSRCFVVGSKDMS-------------------TWVFGAERWDN 178
+T G ++ C+DW D R V S+D TWV +
Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 116
Query: 179 LIYYALGG---------------------------HKDAIVACFFESNSLDLYSLSQDGV 211
A GG H + + AC F ++ + + + S DG
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 176
Query: 212 LCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGK 271
+W ++ G L+ G AD+L + E + T + G ++
Sbjct: 177 CALWDVES---GQLLQSFHGHGADVLCLDLAPSETGN------TFVSGGCD--KKAMVWD 225
Query: 272 VKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFN--LIHSLSIS 329
++ + + F E D N++ ++ +G L++L I+S
Sbjct: 226 MRSGQCVQAFETHESDINSV---RYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESI 282
Query: 330 DQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIV 389
+SV + SG + G + + VW+ S V GH N + L SPDG
Sbjct: 283 IFGASSVDFSLSGRLLFAGYNDY-TINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFC 341
Query: 390 TGGDDGKVKVW 400
+G D ++VW
Sbjct: 342 SGSWDHTLRVW 352
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 93.6 bits (231), Expect = 8e-19
Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 6/193 (3%)
Query: 340 SSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPD--GQYIVTGGDDGKV 397
++ D SG G +W+ +S + GH ++ L +P G V+GG D K
Sbjct: 204 TNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKA 263
Query: 398 KVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR 457
VW+ SG C F H S + V + +G + S D T R +DL R + S
Sbjct: 264 MVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKE 322
Query: 458 PTQFSCVAVD--ASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSV 515
F +VD SG ++ AG D + I VW + G + +L GHE +S L +P +
Sbjct: 323 SIIFGASSVDFSLSGRLLFAGYND-YTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTA 381
Query: 516 LASASWDKTVRLW 528
S SWD T+R+W
Sbjct: 382 FCSGSWDHTLRVW 394
Score = 59.3 bits (142), Expect = 2e-08
Identities = 57/233 (24%), Positives = 99/233 (42%), Gaps = 20/233 (8%)
Query: 353 GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVW------NTLSGF 406
G+++VW+ + + ++A AY+P G I GG D K V+ N
Sbjct: 127 GKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAA 186
Query: 407 CFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCV-- 464
+ H++ ++ +FT + ++T+S DGT +D+ + ++F C+
Sbjct: 187 KKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHG-HGADVLCLDL 245
Query: 465 AVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKT 524
A +G +G D + VW M++G+ + HE I+ + + P AS S D T
Sbjct: 246 APSETGNTFVSGGCDK-KAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDAT 304
Query: 525 VRLWDMFDSWRTKETLALTS------DALAVTFRPDGAELAVATLNSQITFWD 571
RL+D+ R +A+ S A +V F G L + I WD
Sbjct: 305 CRLYDL----RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWD 353
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/215 (20%), Positives = 86/215 (40%), Gaps = 20/215 (9%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHS-----SGVTGVTFT 424
+GH N ++ + + D + IV+ DGKV VW++ F T EH+ + V +
Sbjct: 102 KGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDS-----FTTNKEHAVTMPCTWVMACAYA 156
Query: 425 ATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQF------SCVAVDASGEIVSAGAQ 478
+G + +D + L +N + +C ++ +I++A
Sbjct: 157 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 216
Query: 479 DSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK--SVLASASWDKTVRLWDMFDSWRT 536
+ + W +++G+LL GH + L P + + S DK +WDM
Sbjct: 217 GTCAL--WDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV 274
Query: 537 KETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ SD +V + P G A + ++ +D
Sbjct: 275 QAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
Score = 39.7 bits (91), Expect = 0.013
Identities = 63/311 (20%), Positives = 108/311 (34%), Gaps = 63/311 (20%)
Query: 138 KTYFGPYDETTCIDWTDDSRCFVVGSKDMS-------------------TWVFGAERWDN 178
+T G ++ C+DW D R V S+D TWV +
Sbjct: 99 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS 158
Query: 179 LIYYALGG---------------------------HKDAIVACFFESNSLDLYSLSQDGV 211
A GG H + + AC F ++ + + + S DG
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGT 218
Query: 212 LCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGK 271
+W ++ G L+ G AD+L + E + T + G ++
Sbjct: 219 CALWDVES---GQLLQSFHGHGADVLCLDLAPSETGN------TFVSGGCD--KKAMVWD 267
Query: 272 VKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFN--LIHSLSIS 329
++ + + F E D N++ ++ +G L++L I+S
Sbjct: 268 MRSGQCVQAFETHESDINSV---RYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESI 324
Query: 330 DQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIV 389
+SV + SG + G + + VW+ S V GH N + L SPDG
Sbjct: 325 IFGASSVDFSLSGRLLFAGYNDY-TINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFC 383
Query: 390 TGGDDGKVKVW 400
+G D ++VW
Sbjct: 384 SGSWDHTLRVW 394
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 93.2 bits (230), Expect = 1e-18
Identities = 55/181 (30%), Positives = 84/181 (46%), Gaps = 2/181 (1%)
Query: 350 SGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
SG +W+ ++ GH +++L+ SPD + V+G D K+W+ G C
Sbjct: 161 SGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQ 220
Query: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR-PTQFSCVAVDA 468
+FT H S + V+F GY T S D T R FDL + ++ + VA
Sbjct: 221 SFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSK 280
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
SG ++ AG D F VW G VL+GH+ +S L +A+ SWD +R+W
Sbjct: 281 SGRLLLAG-YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339
Query: 529 D 529
+
Sbjct: 340 N 340
Score = 66.2 bits (160), Expect = 1e-10
Identities = 58/257 (22%), Positives = 102/257 (39%), Gaps = 23/257 (8%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + A+ + D + +V+ DGK+ +W++ + SS V + +G
Sbjct: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111
Query: 430 VVTSSMDGTVRAFDLH-RYRNFRTFTS-PRPTQF-SCVAVDASGEIVSAGAQDSFEIFVW 486
V +D ++L R N R P T + SC +IV++ + + W
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCAL--W 169
Query: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
++T + +GH G + L +P S + D + +LWD+ D + SD
Sbjct: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229
Query: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGK 606
AV+F P+G A TGS + L R + + + H
Sbjct: 230 NAVSFFPNGYAFA------------------TGSDDATCRLFDLRADQELLLYSHDNIIC 271
Query: 607 AFTALCYSADGHSILAG 623
T++ +S G +LAG
Sbjct: 272 GITSVAFSKSGRLLLAG 288
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 92.8 bits (229), Expect = 1e-18
Identities = 79/357 (22%), Positives = 145/357 (40%), Gaps = 31/357 (8%)
Query: 237 LQREEEEEEEEDQEGDRETTIRG----KATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLT 292
LQ++ E E + E E T G K P E KY+ G + +T
Sbjct: 61 LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYAL--------SGHRSPVT 112
Query: 293 AAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGL 352
FH ++V+ + + + +L S+ ++ + SG +A CS
Sbjct: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA-SCSAD 171
Query: 353 GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFT 412
+ +W++Q + GH +++ ++A P+G +IV+ D +K+W +G+C TFT
Sbjct: 172 MTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFT 231
Query: 413 EHSSGVTGVTFTATGYVVVTSSMDGTVRAF---------DLHRYRNFRTFTSPRP-TQFS 462
H V V G ++ + S D TVR + +L + + S P + +S
Sbjct: 232 GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYS 291
Query: 463 CVAVDASGEIVSAGAQDSF--------EIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKS 514
++ E +G F I +W + TG L L GH+ + G+ F+
Sbjct: 292 SISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGK 351
Query: 515 VLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ S + DKT+R+WD + K A ++ F + +++ + W+
Sbjct: 352 FILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 42.7 bits (99), Expect = 0.002
Identities = 49/271 (18%), Positives = 107/271 (39%), Gaps = 13/271 (4%)
Query: 137 DKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFF 196
++T G D I + + S DM+ ++ + ++ + + GH + +
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECI--RTMHGHDHNVSSVAI 200
Query: 197 ESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETT 256
N + S S+D + MW+ T G +K G + + ++ + T
Sbjct: 201 MPNGDHIVSASRDKTIKMWEVQT---GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257
Query: 257 IRGKATPAEEEKTGKVKYSRLAKYF-FNKEGDFNNLTAAA------FHKKSHLLVTGFAS 309
+R +E K ++ + + + E +++++ A K L++G
Sbjct: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
Query: 310 GIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQ 369
+ ++ + +L D + V +S G +I C+ L VW+++++ +
Sbjct: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFI-LSCADDKTLRVWDYKNKRCMKTL 376
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVW 400
H + + +L + Y+VTG D VKVW
Sbjct: 377 NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 92.8 bits (229), Expect = 1e-18
Identities = 65/274 (23%), Positives = 116/274 (42%), Gaps = 46/274 (16%)
Query: 299 KSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVW 358
K+ L ++ A+ + E P + L +L ++++SV + +G+W+A S +++W
Sbjct: 10 KAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLA-SSSADRLIIIW 68
Query: 359 EWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGV 418
Y GH + +A+S D +V+ DD +K+W+ SG C T HS+ V
Sbjct: 69 GAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Query: 419 TGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQ 478
F ++++ S D TV+
Sbjct: 129 FCCNFNPPSNLIISGSFDETVK-------------------------------------- 150
Query: 479 DSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKE 538
+W ++TG+ L LS H P+S + FN S++ S S+D R+WD K
Sbjct: 151 ------IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 539 TLALTSDALA-VTFRPDGAELAVATLNSQITFWD 571
+ + ++ V F P+G + ATL++ + WD
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Score = 84.3 bits (207), Expect = 5e-16
Identities = 61/256 (23%), Positives = 116/256 (45%), Gaps = 62/256 (24%)
Query: 324 HSLSISD---QSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALA 380
H+L ISD S +S +++S D L +W+ +S + +GH N +
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDD---------KTLKLWDVRSGKCLKTLKGHSNYVFCCN 132
Query: 381 YSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDG--- 437
++P I++G D VK+W +G C T + HS V+ V F +G ++V+ S DG
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Query: 438 ----------------------------------------TVRAFDLHRYRNFRTFTSPR 457
T++ +D R R +T+T +
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
Query: 458 PTQFSCVAVDAS---GEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKS 514
++ C+ + S G+ + +G++D+ +++W++QT ++ L GH + +P ++
Sbjct: 253 NEKY-CIFANFSVTGGKWIVSGSEDNL-VYIWNLQTKEIVQKLQGHTDVVISAACHPTEN 310
Query: 515 VLASASW--DKTVRLW 528
++ASA+ DKT++LW
Sbjct: 311 LIASAALENDKTIKLW 326
Score = 37.4 bits (85), Expect = 0.065
Identities = 21/87 (24%), Positives = 39/87 (44%)
Query: 497 LSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGA 556
L GH +S + F+P LAS+S D+ + +W +D K + V + D +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 557 ELAVATLNSQITFWDPENAVQTGSIEG 583
L A+ + + WD + +++G
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKG 123
Score = 32.7 bits (73), Expect = 1.6
Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 16/126 (12%)
Query: 98 SVHSVSFSPDGRKFVVTKGN-IAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDS 156
+V SV FSP+G + + + ++ A K E KT +G E + + W+ DS
Sbjct: 43 AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE-------KTLYGHNLEISDVAWSSDS 95
Query: 157 RCFVVGSKDMSTWVFGAERWD---NLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLC 213
V S D + + WD L GH + + C F S + S S D +
Sbjct: 96 SRLVSASDDKT-----LKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 214 MWQCDT 219
+W+ T
Sbjct: 151 IWEVKT 156
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 92.0 bits (227), Expect = 2e-18
Identities = 60/199 (30%), Positives = 92/199 (46%), Gaps = 2/199 (1%)
Query: 385 GQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDL 444
G+ + TGGDD +V +W+ C ++ T H+S V V ++V S G++R +DL
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 445 HRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPI 504
+ RT + + GE V++G+QD+ I +W ++ + GH +
Sbjct: 93 EAAKILRTLMGHK-ANICSLDFHPYGEFVASGSQDT-NIKLWDIRRKGCVFRYRGHSQAV 150
Query: 505 SGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLN 564
L F+P LASA+ D TV+LWD+ E T V F P+ LA + +
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210
Query: 565 SQITFWDPENAVQTGSIEG 583
I FWD E IEG
Sbjct: 211 RTIRFWDLEKFQVVSCIEG 229
Score = 86.7 bits (213), Expect = 9e-17
Identities = 53/222 (23%), Positives = 105/222 (47%), Gaps = 4/222 (1%)
Query: 286 GDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWI 345
G + + + + L+V G SG + +L ++ +L +I S+ + G+++
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
Query: 346 AFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSG 405
A G + +W+ + + V + +GH ++ L +SPDG+++ + DD VK+W+ +G
Sbjct: 121 ASGSQDTN-IKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG 179
Query: 406 FCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVA 465
F H+ V V F Y++ + S D T+R +DL +++ P V
Sbjct: 180 KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG-EPGPVRSVL 238
Query: 466 VDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGL 507
+ G + +G QDS ++ W + R DV+ + G ++ L
Sbjct: 239 FNPDGCCLYSGCQDSLRVYGWEPE--RCFDVVLVNWGKVADL 278
Score = 85.1 bits (209), Expect = 3e-16
Identities = 66/287 (22%), Positives = 118/287 (41%), Gaps = 47/287 (16%)
Query: 289 NNLTAAAFHKKS-HLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAF 347
+N+++ K S LL TG +L + + N I SL+ + SV +N+ + I
Sbjct: 21 SNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVA 80
Query: 348 GCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFC 407
G S G + VW+ ++ + GH ++ +L + P G+++ +G D +K+W+ C
Sbjct: 81 G-SQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139
Query: 408 FVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVD 467
+ HS V + F+ G +
Sbjct: 140 VFRYRGHSQAVRCLRFSPDGKWL------------------------------------- 162
Query: 468 ASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRL 527
A A D + +W + G+++ GH GP++ + F+P + +LAS S D+T+R
Sbjct: 163 -------ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
Query: 528 WDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNS-QITFWDPE 573
WD+ +V F PDG L +S ++ W+PE
Sbjct: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
Score = 32.3 bits (72), Expect = 2.1
Identities = 22/100 (22%), Positives = 38/100 (38%), Gaps = 2/100 (2%)
Query: 264 AEEEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLI 323
A ++ T K+ K G + FH +LL +G + +L +F ++
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV 224
Query: 324 HSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSE 363
+ + SV N G + GC L V+ W+ E
Sbjct: 225 SCIEGEPGPVRSVLFNPDGCCLYSGCQ--DSLRVYGWEPE 262
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 91.7 bits (226), Expect = 3e-18
Identities = 50/159 (31%), Positives = 81/159 (50%), Gaps = 2/159 (1%)
Query: 372 HFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVV 431
H + + A+SPDGQ ++TG +DG V W T SG H+ V F+ G++
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 432 TSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTG 491
++S D TVR +D+ R + R V+ +++G D + +W +Q+G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKG-HQRSVETVSFSPDSRQLASGGWDK-RVMLWDVQSG 137
Query: 492 RLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
++L +L GH I F+P + LA+ SWD TV +WD+
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 89.0 bits (219), Expect = 2e-17
Identities = 73/283 (25%), Positives = 122/283 (43%), Gaps = 10/283 (3%)
Query: 276 RLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIAS 335
R K+F G+ N+ +AF +L+TG G + E L+ L +
Sbjct: 12 RRVKFFGQHGGEVNS---SAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKF 68
Query: 336 VAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDG 395
+ G A + +W+ + +GH S+ +++SPD + + +GG D
Sbjct: 69 CRFSPDGHLFASASCDC-TVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDK 127
Query: 396 KVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTS 455
+V +W+ SG H + F+ T + T S D TV +DL + +
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 456 --PRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
SC+ ASG ++++G+ D I +W T LL L GH + + F+P +
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDK-TIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 514 SVLASASWDKTVRLWDMFDSWRTKETLALTSD-ALAVTFRPDG 555
LASA + + V++WD ++ + ETL D A F PDG
Sbjct: 246 LWLASAGYSRMVKVWDC-NTGKCLETLKGVLDVAHTCAFTPDG 287
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/185 (27%), Positives = 81/185 (43%), Gaps = 28/185 (15%)
Query: 465 AVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKT 524
A G+++ G++D ++ W ++G+LL L GH GP+ F+P + ASAS D T
Sbjct: 28 AFSPDGQMLLTGSEDGC-VYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCT 86
Query: 525 VRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGR 584
VRLWD+ + + V+F PD +LA + ++ WD ++ + G
Sbjct: 87 VRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
Query: 585 HD-------------LKTGR----------KELDKITAKHAAKGKA--FTALCYSADGHS 619
D L TG + + + A +G + + LCYSA G
Sbjct: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-- 204
Query: 620 ILAGG 624
+LA G
Sbjct: 205 LLASG 209
Score = 31.6 bits (70), Expect = 3.6
Identities = 34/136 (25%), Positives = 55/136 (40%), Gaps = 8/136 (5%)
Query: 98 SVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDDSR 157
SV +VSFSPD R+ + M + + + + G D D++
Sbjct: 107 SVETVSFSPDSRQLASGGWDKRVMLW------DVQSGQMLRLLVGHRDSIQSSDFSPTVN 160
Query: 158 CFVVGSKDMSTWVFGAERWDNLI-YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQ 216
C GS D + ++ + + AL GH A ++C S S L S S D + +W+
Sbjct: 161 CLATGSWDSTVHIWDLRMVTPAVSHQALEGH-SANISCLCYSASGLLASGSWDKTIHIWK 219
Query: 217 CDTPPEGLRLKPPAGW 232
T ++LK W
Sbjct: 220 PTTSSLLIQLKGHVTW 235
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 89.4 bits (220), Expect = 1e-17
Identities = 51/181 (28%), Positives = 82/181 (45%), Gaps = 2/181 (1%)
Query: 350 SGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
SG +W+ ++ GH +++L+ +PD + V+G D K+W+ G C
Sbjct: 161 SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220
Query: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR-PTQFSCVAVDA 468
TFT H S + + F G T S D T R FDL + T++ + V+
Sbjct: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSK 280
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
SG ++ AG D F VW VL+GH+ +S L +A+ SWD +++W
Sbjct: 281 SGRLLLAG-YDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339
Query: 529 D 529
+
Sbjct: 340 N 340
Score = 68.2 bits (165), Expect = 3e-11
Identities = 57/257 (22%), Positives = 102/257 (39%), Gaps = 23/257 (8%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + A+ + D + +V+ DGK+ +W++ + SS V + +G
Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111
Query: 430 VVTSSMDGTVRAFDLH-RYRNFRTFT--SPRPTQFSCVAVDASGEIVSAGAQDSFEIFVW 486
V +D ++L R N R + SC +IV++ + + W
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCAL--W 169
Query: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
++TG+ +GH G + L P + S + D + +LWD+ + + SD
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229
Query: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGK 606
A+ F P+G NA TGS + L R + + +T H
Sbjct: 230 NAICFFPNG------------------NAFATGSDDATCRLFDLRADQELMTYSHDNIIC 271
Query: 607 AFTALCYSADGHSILAG 623
T++ +S G +LAG
Sbjct: 272 GITSVSFSKSGRLLLAG 288
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 89.0 bits (219), Expect = 2e-17
Identities = 52/181 (28%), Positives = 81/181 (44%), Gaps = 2/181 (1%)
Query: 350 SGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
SG +W+ ++ GH ++LA SPD ++G D K+W+ G C
Sbjct: 161 SGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQ 220
Query: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPR-PTQFSCVAVDA 468
TFT H S + + F G + T S D + R FDL + F+ + VA
Sbjct: 221 TFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSL 280
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
SG ++ AG D F VW + +LSGH+ +S L +A+ SWD +++W
Sbjct: 281 SGRLLFAG-YDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIW 339
Query: 529 D 529
+
Sbjct: 340 N 340
Score = 65.1 bits (157), Expect = 3e-10
Identities = 57/257 (22%), Positives = 102/257 (39%), Gaps = 23/257 (8%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + A+ ++ D + +V+ DGK+ VW++ + SS V + +G
Sbjct: 52 RGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
Query: 430 VVTSSMDGTVRAFDLH-RYRNFRTFT--SPRPTQFSCVAVDASGEIVSAGAQDSFEIFVW 486
V +D ++L R N + S SC IV++ + + W
Sbjct: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCAL--W 169
Query: 487 SMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA 546
++TG+ V GH G L +P ++ S + D + +LWD+ + + SD
Sbjct: 170 DIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
Query: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGK 606
A+ F P+G A+ TGS + L R + + I H +
Sbjct: 230 NAICFFPNG------------------EAICTGSDDASCRLFDLRADQELICFSHESIIC 271
Query: 607 AFTALCYSADGHSILAG 623
T++ +S G + AG
Sbjct: 272 GITSVAFSLSGRLLFAG 288
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 87.4 bits (215), Expect = 5e-17
Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 2/172 (1%)
Query: 357 VWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSS 416
VW + ++ H N + +SPDG+ IV+ DD VK+W+ S C ++ EH
Sbjct: 91 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 150
Query: 417 GVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAG 476
VT V F +G + + MD TV+ +D+ +R + + + ++ SG +
Sbjct: 151 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITA 209
Query: 477 AQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
+ DS + + + GRLL L GH+GP + + F+ AS D+ V +W
Sbjct: 210 SSDS-TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 84.0 bits (206), Expect = 6e-16
Identities = 68/279 (24%), Positives = 121/279 (43%), Gaps = 24/279 (8%)
Query: 355 LLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414
L+VW + +S + GH +++ + +SP G + +G D V++W F H
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAH 64
Query: 415 SSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVS 474
++ V V F + G VT+S D TV+ + HR + F S C G ++
Sbjct: 65 TATVRSVHFCSDGQSFVTASDDKTVKVWATHR-QKFLFSLSQHINWVRCAKFSPDGRLI- 122
Query: 475 AGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSW 534
A D + +W + + H G ++ + F+P + +A+A D TV++WD+ +
Sbjct: 123 VSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-RTH 181
Query: 535 RTKETLALTSDAL-AVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKE 593
R + L S A+ ++F P G L A+ +S + D +EGR
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD--------LMEGR--------- 224
Query: 594 LDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIY 632
+ H +G A T + +S G +GG + V ++
Sbjct: 225 --LLYTLHGHQGPA-TTVAFSRTGEYFASGGSDEQVMVW 260
Score = 77.4 bits (189), Expect = 6e-14
Identities = 65/247 (26%), Positives = 109/247 (44%), Gaps = 19/247 (7%)
Query: 332 SIASVAINSSGDWIAFGCSGLGQLLVW--EWQSESYVLKQQGHFNSMVALAYSPDGQYIV 389
++ V + SG +A G S + +W + ES V + H ++ ++ + DGQ V
Sbjct: 25 AVTCVNFSPSGHLLASG-SRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQSFV 81
Query: 390 TGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD------ 443
T DD VKVW T + ++H + V F+ G ++V++S D TV+ +D
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 141
Query: 444 LHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGP 503
+H Y F + V SG ++A D+ + VW ++T RLL H
Sbjct: 142 VHSYCEHGGFV-------TYVDFHPSGTCIAAAGMDN-TVKVWDVRTHRLLQHYQLHSAA 193
Query: 504 ISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATL 563
++GL F+P + L +AS D T+++ D+ + A V F G A
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 564 NSQITFW 570
+ Q+ W
Sbjct: 254 DEQVMVW 260
Score = 60.8 bits (146), Expect = 5e-09
Identities = 48/178 (26%), Positives = 73/178 (41%), Gaps = 2/178 (1%)
Query: 394 DGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTF 453
D + VW+ FT H VT V F+ +G+++ + S D TVR + + F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 454 TSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMK 513
+ T S V+ A D + VW+ + L LS H + F+P
Sbjct: 62 RAHTATVRSVHFCSDGQSFVT--ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 514 SVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
++ SAS DKTV+LWD V F P G +A A +++ + WD
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD 177
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/267 (17%), Positives = 96/267 (35%), Gaps = 27/267 (10%)
Query: 140 YFGPYDETTCIDWTDDSRCFVVGSKDMST--WVFGAERWDNLIYYALGGHKDAIVACFFE 197
+ G D TC++++ GS+D + WV + ++ ++ A H + + F
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNV-KGESTVFRA---HTATVRSVHFC 74
Query: 198 SNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTI 257
S+ + S D + +W L W +
Sbjct: 75 SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR-------------- 120
Query: 258 RGKATPAEEEKTGKV--KYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLH 315
A ++KT K+ K SR + + + G F +T FH + +
Sbjct: 121 --LIVSASDDKTVKLWDKSSRECVHSYCEHGGF--VTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 316 ELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNS 375
++ L+ + ++ ++ + SG+++ S L + + + GH
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSD-STLKILDLMEGRLLYTLHGHQGP 235
Query: 376 MVALAYSPDGQYIVTGGDDGKVKVWNT 402
+A+S G+Y +GG D +V VW +
Sbjct: 236 ATTVAFSRTGEYFASGGSDEQVMVWKS 262
Score = 32.7 bits (73), Expect = 1.6
Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 2/92 (2%)
Query: 19 NLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGG 77
+++F DG S ++ ++ + + L+ N V+C SPDGRL + +
Sbjct: 70 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 129
Query: 78 DALLVSLVCRSVLHHF-HFKGSVHSVSFSPDG 108
L R +H + G V V F P G
Sbjct: 130 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 87.4 bits (215), Expect = 5e-17
Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 2/172 (1%)
Query: 357 VWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSS 416
VW + ++ H N + +SPDG+ IV+ DD VK+W+ S C ++ EH
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 417 GVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAG 476
VT V F +G + + MD TV+ +D+ +R + + + ++ SG +
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITA 247
Query: 477 AQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
+ DS + + + GRLL L GH+GP + + F+ AS D+ V +W
Sbjct: 248 SSDS-TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 77.8 bits (190), Expect = 4e-14
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 19/294 (6%)
Query: 285 EGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDW 344
+G + +T F + L +G + + + + + ++ V + SG
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 345 IAFGCSGLGQLLVW--EWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNT 402
+A G S + +W + ES V + H ++ ++ + DGQ VT DD VKVW T
Sbjct: 76 LASG-SRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 403 LSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD------LHRYRNFRTFTSP 456
+ ++H + V F+ G ++V++S D TV+ +D +H Y F
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV-- 190
Query: 457 RPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVL 516
+ V SG ++A D+ + VW ++T RLL H ++GL F+P + L
Sbjct: 191 -----TYVDFHPSGTCIAAAGMDN-TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 517 ASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFW 570
+AS D T+++ D+ + A V F G A + Q+ W
Sbjct: 245 ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/202 (25%), Positives = 87/202 (43%), Gaps = 2/202 (0%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH +++ + +S + + + +G D + VW+ FT H VT V F+ +G++
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 430 VVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQ 489
+ + S D TVR + + F + T S V+A D + VW+
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKTVKVWATH 133
Query: 490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAV 549
+ L LS H + F+P ++ SAS DKTV+LWD V
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 550 TFRPDGAELAVATLNSQITFWD 571
F P G +A A +++ + WD
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWD 215
Score = 48.9 bits (115), Expect = 2e-05
Identities = 56/295 (18%), Positives = 109/295 (36%), Gaps = 33/295 (11%)
Query: 136 LDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACF 195
L++ + G D TC+D++ +++ GS D V+ + Y GHKDA+
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA--YRFTGHKDAVTCVN 68
Query: 196 FESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEE---EEEDQEGD 252
F + L S S+D + +W + E + + + + +D+
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 253 RETTIRGK-----------------------ATPAEEEKTGKV--KYSRLAKYFFNKEGD 287
T R K A ++KT K+ K SR + + + G
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 288 FNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAF 347
F +T FH + + ++ L+ + ++ ++ + SG+++
Sbjct: 189 F--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 348 GCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNT 402
S L + + + GH +A+S G+Y +GG D +V VW +
Sbjct: 247 ASSD-STLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/256 (19%), Positives = 90/256 (35%), Gaps = 44/256 (17%)
Query: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAEL 558
GH ++ + F+ LAS S D + +W M R V F P G L
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 559 AVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGH 618
A + + + W P +++G + H A ++ + +DG
Sbjct: 77 ASGSRDKTVRIWVP-------NVKGE----------STVFRAHTA---TVRSVHFCSDGQ 116
Query: 619 SILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQ 678
S + K V ++ Q + SL ++ K + G L + D
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL--------FSLSQHINWVRCAKFSPDGRLIVSASDD-- 166
Query: 679 EDGVAIPLPGVRKGDMSSR-----HFKPEIRVTSLRFSPTGRCWAATTTEGLL-IYSLDT 732
V+ D SSR + + VT + F P+G C AA + + ++ + T
Sbjct: 167 --------KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
Query: 733 RVLFDPFELDTSVTPG 748
L ++L ++ G
Sbjct: 219 HRLLQHYQLHSAAVNG 234
Score = 32.7 bits (73), Expect = 1.6
Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 2/92 (2%)
Query: 19 NLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGG 77
+++F DG S ++ ++ + + L+ N V+C SPDGRL + +
Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167
Query: 78 DALLVSLVCRSVLHHF-HFKGSVHSVSFSPDG 108
L R +H + G V V F P G
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 87.4 bits (215), Expect = 5e-17
Identities = 49/172 (28%), Positives = 83/172 (48%), Gaps = 2/172 (1%)
Query: 357 VWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSS 416
VW + ++ H N + +SPDG+ IV+ DD VK+W+ S C ++ EH
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 417 GVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAG 476
VT V F +G + + MD TV+ +D+ +R + + + ++ SG +
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITA 247
Query: 477 AQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
+ DS + + + GRLL L GH+GP + + F+ AS D+ V +W
Sbjct: 248 SSDS-TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 77.8 bits (190), Expect = 4e-14
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 19/294 (6%)
Query: 285 EGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDW 344
+G + +T F + L +G + + + + + ++ V + SG
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 345 IAFGCSGLGQLLVW--EWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNT 402
+A G S + +W + ES V + H ++ ++ + DGQ VT DD VKVW T
Sbjct: 76 LASG-SRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWAT 132
Query: 403 LSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFD------LHRYRNFRTFTSP 456
+ ++H + V F+ G ++V++S D TV+ +D +H Y F
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV-- 190
Query: 457 RPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVL 516
+ V SG ++A D+ + VW ++T RLL H ++GL F+P + L
Sbjct: 191 -----TYVDFHPSGTCIAAAGMDN-TVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 244
Query: 517 ASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFW 570
+AS D T+++ D+ + A V F G A + Q+ W
Sbjct: 245 ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/202 (25%), Positives = 87/202 (43%), Gaps = 2/202 (0%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH +++ + +S + + + +G D + VW+ FT H VT V F+ +G++
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 430 VVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQ 489
+ + S D TVR + + F + T S V+A D + VW+
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS--DDKTVKVWATH 133
Query: 490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAV 549
+ L LS H + F+P ++ SAS DKTV+LWD V
Sbjct: 134 RQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYV 193
Query: 550 TFRPDGAELAVATLNSQITFWD 571
F P G +A A +++ + WD
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWD 215
Score = 48.9 bits (115), Expect = 2e-05
Identities = 56/295 (18%), Positives = 109/295 (36%), Gaps = 33/295 (11%)
Query: 136 LDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACF 195
L++ + G D TC+D++ +++ GS D V+ + Y GHKDA+
Sbjct: 11 LERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA--YRFTGHKDAVTCVN 68
Query: 196 FESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEEEE---EEEDQEGD 252
F + L S S+D + +W + E + + + + +D+
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 253 RETTIRGK-----------------------ATPAEEEKTGKV--KYSRLAKYFFNKEGD 287
T R K A ++KT K+ K SR + + + G
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 288 FNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAF 347
F +T FH + + ++ L+ + ++ ++ + SG+++
Sbjct: 189 F--VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 348 GCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNT 402
S L + + + GH +A+S G+Y +GG D +V VW +
Sbjct: 247 ASSD-STLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKS 300
Score = 33.1 bits (74), Expect = 1.2
Identities = 51/256 (19%), Positives = 90/256 (35%), Gaps = 44/256 (17%)
Query: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAEL 558
GH ++ + F+ LAS S D + +W M R V F P G L
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 559 AVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGH 618
A + + + W P +++G + H A ++ + +DG
Sbjct: 77 ASGSRDKTVRIWVP-------NVKGE----------STVFRAHTA---TVRSVHFCSDGQ 116
Query: 619 SILAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQ 678
S + K V ++ Q + SL ++ K + G L + D
Sbjct: 117 SFVTASDDKTVKVWATHRQKFL--------FSLSQHINWVRCAKFSPDGRLIVSASDD-- 166
Query: 679 EDGVAIPLPGVRKGDMSSR-----HFKPEIRVTSLRFSPTGRCWAATTTEGLL-IYSLDT 732
V+ D SSR + + VT + F P+G C AA + + ++ + T
Sbjct: 167 --------KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218
Query: 733 RVLFDPFELDTSVTPG 748
L ++L ++ G
Sbjct: 219 HRLLQHYQLHSAAVNG 234
Score = 32.7 bits (73), Expect = 1.6
Identities = 23/92 (25%), Positives = 38/92 (41%), Gaps = 2/92 (2%)
Query: 19 NLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYN-VKCVGLSPDGRLAIIVDEGG 77
+++F DG S ++ ++ + + L+ N V+C SPDGRL + +
Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167
Query: 78 DALLVSLVCRSVLHHF-HFKGSVHSVSFSPDG 108
L R +H + G V V F P G
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 199
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 87.0 bits (214), Expect = 7e-17
Identities = 51/214 (23%), Positives = 95/214 (44%), Gaps = 2/214 (0%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + + + D +++ +D ++ W+ S V + H+ V + +
Sbjct: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLY 398
Query: 430 VVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQ 489
+ S D T R + R R + CV + ++ G+ D + +WS Q
Sbjct: 399 FASGSHDRTARLWSFDRTYPLRIYAG-HLADVDCVKFHPNSNYLATGSTDK-TVRLWSAQ 456
Query: 490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAV 549
G + + +GH GP+ L F+P LASA D+ ++LWD+ KE T + ++
Sbjct: 457 QGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSL 516
Query: 550 TFRPDGAELAVATLNSQITFWDPENAVQTGSIEG 583
TF PD +A A++++ + WD N + +G
Sbjct: 517 TFSPDSGLIASASMDNSVRVWDIRNTYCSAPADG 550
Score = 80.9 bits (198), Expect = 5e-15
Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 2/201 (0%)
Query: 349 CSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCF 408
CS + W+ S + + QGH + L SP Y +G D ++W+ +
Sbjct: 360 CSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPL 419
Query: 409 VTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDA 468
+ H + V V F + T S D TVR + + + R FT R S +A
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS-LAFSP 478
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
+G+ +++ +D + +W + +G L L GH I+ L F+P ++ASAS D +VR+W
Sbjct: 479 NGKYLASAGEDQ-RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Query: 529 DMFDSWRTKETLALTSDALAV 549
D+ +++ + +S+ + V
Sbjct: 538 DIRNTYCSAPADGSSSELVGV 558
Score = 71.6 bits (174), Expect = 3e-12
Identities = 67/273 (24%), Positives = 120/273 (43%), Gaps = 41/273 (15%)
Query: 241 EEEEEEEDQEGDRETTIRGKATPAEE-----EKTGKVKYSRLAKYFFNKEGDFNNLTAAA 295
EEE++E+D G +RG P + +G + S + G F N
Sbjct: 322 EEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ 381
Query: 296 FHKKS--HLLVTG----FASGIF-HLHELPEFNLIHSLSISDQSIASV---AINSSGDWI 345
H L ++ FASG L F+ + L I +A V + + +++
Sbjct: 382 GHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL 441
Query: 346 AFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSG 405
A G + + +W Q + V GH +++LA+SP+G+Y+ + G+D ++K+W+ SG
Sbjct: 442 ATGSTDK-TVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 406 FCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVA 465
+ H+ +T +TF+ ++ ++SMD +VR +D+ R T S A
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI------------RNTYCSAPA 548
Query: 466 VDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLS 498
+S E+V + TG++ +VLS
Sbjct: 549 DGSSSELV-------------GVYTGQMSNVLS 568
Score = 53.1 bits (126), Expect = 1e-06
Identities = 48/222 (21%), Positives = 85/222 (38%), Gaps = 22/222 (9%)
Query: 414 HSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIV 473
H V F A +++ S D ++R +DL + N + + + +
Sbjct: 341 HCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWD-LDISPYSLYF 399
Query: 474 SAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDS 533
++G+ D +WS L + +GH + + F+P + LA+ S DKTVRLW
Sbjct: 400 ASGSHDR-TARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
Query: 534 WRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKE 593
+ L++ F P+G LA A + ++ WD + + G D
Sbjct: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD------- 511
Query: 594 LDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVR 635
T+L +S D I + M V ++ +R
Sbjct: 512 -------------NITSLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 32.3 bits (72), Expect = 2.1
Identities = 17/78 (21%), Positives = 37/78 (47%), Gaps = 2/78 (2%)
Query: 138 KTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFE 197
+ Y G + C+ + +S GS D + ++ A++ +++ + GH+ +++ F
Sbjct: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFT--GHRGPVLSLAFS 477
Query: 198 SNSLDLYSLSQDGVLCMW 215
N L S +D L +W
Sbjct: 478 PNGKYLASAGEDQRLKLW 495
Score = 31.2 bits (69), Expect = 4.6
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 491 GRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
G + +L GH GP+ F S L S S D ++R WD+
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 82.4 bits (202), Expect = 2e-15
Identities = 52/255 (20%), Positives = 110/255 (43%), Gaps = 20/255 (7%)
Query: 285 EGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDW 344
+G +T+ FH L+ + + +P + + + + ++ ++++++GD+
Sbjct: 261 KGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDY 320
Query: 345 I---------AFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDG 395
+ AF G++L S S+ + PDG TG D
Sbjct: 321 LLSSSDDQYWAFSDIQTGRVLTKVTDETSGC--------SLTCAQFHPDGLIFGTGTMDS 372
Query: 396 KVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTS 455
++K+W+ F HS +T + F+ GY + T++ D +V+ +DL + +NF+T
Sbjct: 373 QIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQL 432
Query: 456 PRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSV 515
+ + D SG ++ G D +I++ T L + H G +G+ F
Sbjct: 433 DNNFEVKSLIFDQSGTYLALGGTD-VQIYICKQWTEIL--HFTEHSGLTTGVAFGHHAKF 489
Query: 516 LASASWDKTVRLWDM 530
+AS D++++ + +
Sbjct: 490 IASTGMDRSLKFYSL 504
Score = 81.3 bits (199), Expect = 4e-15
Identities = 54/216 (25%), Positives = 99/216 (45%), Gaps = 5/216 (2%)
Query: 355 LLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414
++V++ SE + +GH + ++ + P + + D +++W+ + C H
Sbjct: 246 VVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRAH 305
Query: 415 SSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRP-TQFSCVAVDASGEIV 473
S VTG++ ATG +++SS D D+ R T +C G I
Sbjct: 306 ESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIF 365
Query: 474 SAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDS 533
G DS +I +W ++ + GH GPI+ + F+ LA+A+ D +V+LWD+
Sbjct: 366 GTGTMDS-QIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL-RK 423
Query: 534 WRTKETLALTS--DALAVTFRPDGAELAVATLNSQI 567
+ +TL L + + ++ F G LA+ + QI
Sbjct: 424 LKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTDVQI 459
Score = 64.3 bits (155), Expect = 5e-10
Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 5/214 (2%)
Query: 361 QSESYVLKQQGHFNSMVALAYSP-DGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVT 419
Q S+V ++AL P D I+TGG D V V++ S T H+ VT
Sbjct: 209 QVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVT 268
Query: 420 GVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQD 479
V F + +V ++S D T+R + + + + + + +++ A+G+ + + + D
Sbjct: 269 SVVFHPSQDLVFSASPDATIRIWSVPNASCVQVVRA-HESAVTGLSLHATGDYLLSSSDD 327
Query: 480 SFEIFVWSMQTGRLLDVLSGHEGPISGLC--FNPMKSVLASASWDKTVRLWDMFDSWRTK 537
+ F +QTGR+L ++ S C F+P + + + D +++WD+ +
Sbjct: 328 QYWAFS-DIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVA 386
Query: 538 ETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ ++ F +G LA A +S + WD
Sbjct: 387 NFPGHSGPITSIAFSENGYYLATAADDSSVKLWD 420
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 81.3 bits (199), Expect = 4e-15
Identities = 58/215 (26%), Positives = 102/215 (47%), Gaps = 20/215 (9%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG-Y 428
+GH +++ L Y+ DG + + D V VW++ +G H+S V G
Sbjct: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
Query: 429 VVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAV---DASGEIVSAGAQDSFEIFV 485
+V T S DGTV+ +D+ + +TF + + +AV D S +I+S G + +I V
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQN----TYQVLAVTFNDTSDQIISGGIDN--DIKV 219
Query: 486 WSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLA---- 541
W ++ +L + GH ++GL + S L S + D TVR+WD+ + KE
Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV-RPFAPKERCVKIFQ 278
Query: 542 -----LTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ L ++ PDG+++A + + + WD
Sbjct: 279 GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Score = 77.8 bits (190), Expect = 4e-14
Identities = 47/191 (24%), Positives = 98/191 (51%), Gaps = 11/191 (5%)
Query: 349 CSGL--GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGF 406
C+G G + +W+ + ++ + Q + ++A+ ++ I++GG D +KVW+
Sbjct: 168 CTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
Query: 407 CFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRY-------RNFRTFTSPRPT 459
T H+ VTG++ ++ G +++++MD TVR +D+ + + F+
Sbjct: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
Query: 460 QFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASA 519
+ G ++AG+ D F ++VW + R+L L GH G I+ + F+P + ++ SA
Sbjct: 287 NLLRCSWSPDGSKIAAGSADRF-VYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
Query: 520 SWDKTVRLWDM 530
S DK + + ++
Sbjct: 346 SSDKRLYMGEI 356
Score = 50.8 bits (120), Expect = 6e-06
Identities = 28/89 (31%), Positives = 47/89 (52%), Gaps = 1/89 (1%)
Query: 496 VLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDA-LAVTFRPD 554
+LSGHEG + F+P S LASA +D+ + LW+++ TL S A + + + D
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 555 GAELAVATLNSQITFWDPENAVQTGSIEG 583
G+ L A+ + + WD E + ++G
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKG 149
Score = 50.8 bits (120), Expect = 6e-06
Identities = 45/163 (27%), Positives = 68/163 (41%), Gaps = 26/163 (15%)
Query: 497 LSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTS-----------D 545
L GH G + L +N S+L SAS DKTV +WD R K TS
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
Query: 546 ALAVTFRPDGA--------ELAVATLNS-----QITFWDPENAVQTGSIEGRHDLKTGRK 592
L T DG + A+ T + +TF D + + +G I+ +D+K
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGID--NDIKVWDL 222
Query: 593 ELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIYHVR 635
+K+T + T L S++G +L+ M V ++ VR
Sbjct: 223 RQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/265 (19%), Positives = 100/265 (37%), Gaps = 27/265 (10%)
Query: 181 YYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQRE 240
Y L GH A++ + ++ L+S S D + +W +T RLK +
Sbjct: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Query: 241 EEEEEEEDQEGDRETTIRGKATPAEEEKTGKVK-YSRLAKYFFNKEGDFNNLTAAAFHKK 299
RG G VK + K + + A F+
Sbjct: 162 -----------------RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDT 204
Query: 300 SHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWE 359
S +++G + +L + L +++ S+ ++++S G ++ + VW+
Sbjct: 205 SDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD-NTVRVWD 263
Query: 360 WQ----SESYVLKQQGHFN----SMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTF 411
+ E V QG+ + +++ ++SPDG I G D V VW+T S
Sbjct: 264 VRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323
Query: 412 TEHSSGVTGVTFTATGYVVVTSSMD 436
H+ + V F +++++S D
Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSD 348
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 81.3 bits (199), Expect = 4e-15
Identities = 48/196 (24%), Positives = 95/196 (48%), Gaps = 14/196 (7%)
Query: 388 IVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG-YVVVTSSMDGTVRAFDLHR 446
+ TG +DG++K+W +G + + H V ++FT +G ++V++S D T+R +DL++
Sbjct: 126 LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNK 185
Query: 447 YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISG 506
+ S C ++ ++ + A + +F+WSM++ L+ L GH+ +
Sbjct: 186 HGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEK-SVFLWSMRSYTLIRKLEGHQSSVVS 244
Query: 507 LCFNPMKSVLASASWDKTVRLWDMFDSWRTK------------ETLALTSDALAVTFRPD 554
F+P ++L +AS+D V +WD + R + ++ S +V F P+
Sbjct: 245 CDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPE 304
Query: 555 GAELAVATLNSQITFW 570
G LA + + W
Sbjct: 305 GLYLATVADDRLLRIW 320
Score = 63.2 bits (152), Expect = 1e-09
Identities = 58/270 (21%), Positives = 103/270 (38%), Gaps = 35/270 (12%)
Query: 302 LLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQ 361
+L TG G + E+ L+ +LS + ++ SG I S L +W+
Sbjct: 125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLN 184
Query: 362 SESYVLKQ-QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTG 420
++ GH + + SPD + + + V +W+ S H S V
Sbjct: 185 KHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS 244
Query: 421 VTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDS 480
F+ ++VT+S D V +D +T R VD A D
Sbjct: 245 CDFSPDSALLVTASYDTNVIMWD--------PYTGERLRSLHHTQVDP--------AMDD 288
Query: 481 FEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETL 540
++ + S+++ +CF+P LA+ + D+ +R+W + +T
Sbjct: 289 SDVHISSLRS----------------VCFSPEGLYLATVADDRLLRIWAL--ELKTPIAF 330
Query: 541 ALTSDALAVTFRPDGAELAVATLNSQITFW 570
A ++ L TF P G +A T + + FW
Sbjct: 331 APMTNGLCCTFFPHGGVIATGTRDGHVQFW 360
Score = 55.1 bits (131), Expect = 3e-07
Identities = 37/119 (31%), Positives = 57/119 (47%), Gaps = 3/119 (2%)
Query: 467 DASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKS-VLASASWDKTV 525
D S +++ G D +I +W +QTG LL LSGH+ + L F P S +L SAS DKT+
Sbjct: 120 DVSCLVLATGLNDG-QIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTL 178
Query: 526 RLWDMFDSWRTKETLA-LTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEG 583
R+WD+ + + L+ + PD + L A + W + +EG
Sbjct: 179 RIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG 237
Score = 30.4 bits (67), Expect = 7.9
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 7/70 (10%)
Query: 158 CFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQC 217
C G K + W + + L GH+ ++V+C F +S L + S D + MW
Sbjct: 213 CSAAGEKSVFLWSMRSYT----LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD- 267
Query: 218 DTPPEGLRLK 227
P G RL+
Sbjct: 268 --PYTGERLR 275
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 79.3 bits (194), Expect = 1e-14
Identities = 77/351 (21%), Positives = 142/351 (40%), Gaps = 77/351 (21%)
Query: 333 IASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQ-QGHFNSMVALAY-----SPDGQ 386
+ S++ + G +A GC GQ+L+W+ + V + GH + L++ +P+ +
Sbjct: 159 VLSISWSPDGRKLASGCKN-GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR 217
Query: 387 YIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHR 446
Y+ + DG V++W+T +G C T H+ VT + + G ++ ++S D T++ + H
Sbjct: 218 YVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHD 276
Query: 447 YRNFRTFTSP--------------------RPTQFSCVAVDASGEIVS------------ 474
RT P + S D G +
Sbjct: 277 GVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLV 336
Query: 475 --------AGAQDSFEIFVWS-MQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTV 525
D F +F+WS + + L ++GH+ I+ + F+P ++ASAS+DK++
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396
Query: 526 RLWDMFDSWRTKETLALTSDALAVTFR----PDGAELAVATLNSQITFWDPENAVQTGSI 581
+LWD RT + LA +A ++ D L + +S + WD + +
Sbjct: 397 KLWD----GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDL 452
Query: 582 EGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIY 632
G D A+ +S DG + +GG K + I+
Sbjct: 453 PGHAD--------------------EVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 66.6 bits (161), Expect = 1e-10
Identities = 85/365 (23%), Positives = 145/365 (39%), Gaps = 75/365 (20%)
Query: 325 SLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPD 384
SL +++ SVA + +G ++A G SG + W+ +E+ +GH + ++++++SPD
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASG-SGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Query: 385 GQYIVTGGDDGKVKVWNTLSG-FCFVTFTEHSSGVTGVTF-----TATGYVVVTSSMDGT 438
G+ + +G +G++ +W+ +G T HS +TG+++ V +SS DG+
Sbjct: 168 GRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 439 VRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLS 498
VR +D R R T +C+ G + SA +QD I VW G L L
Sbjct: 228 VRIWDTTAGRCERILTG-HTQSVTCLRWGGDGLLYSA-SQDR-TIKVWRAHDGVLCRTLQ 284
Query: 499 GHEGPISGL-----------CFNPMKSV-------------------------------L 516
GH ++ + F P ++ L
Sbjct: 285 GHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERL 344
Query: 517 ASASWDKTVRLWDMFDSWRTKETLALTSDAL--AVTFRPDGAELAVATLNSQITFWDPEN 574
S S D T+ LW + + T AL V F PD +A A+ + I WD
Sbjct: 345 VSGSDDFTLFLWSPAED-KKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 575 AVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSILAGGMSKFVCIYHV 634
S+ G H A A + +SAD +++G + ++ V
Sbjct: 404 GKYLASLRG-----------------HVA---AVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 635 REQIL 639
+ Q L
Sbjct: 444 KAQKL 448
Score = 57.8 bits (138), Expect = 5e-08
Identities = 90/401 (22%), Positives = 150/401 (37%), Gaps = 60/401 (14%)
Query: 61 VGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVH---SVSFSPDGRKFV--VTK 115
V SP G+ + GD + + HF KG H S+S+SPDGRK
Sbjct: 120 VAFSPTGKY--LASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKN 177
Query: 116 GNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDW-----TDDSRCFVVGSKDMST-- 168
G I + GK+ + +T G T + W + R SKD S
Sbjct: 178 GQILLWDPSTGKQ-------VGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230
Query: 169 WVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKP 228
W A R + + L GH ++ + + L LYS SQD + +W+ L+
Sbjct: 231 WDTTAGRCERI----LTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLCRTLQG 285
Query: 229 PAGW------KADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLA--KY 280
W D R E E ++ ++G +E + R +
Sbjct: 286 HGHWVNTMALSTDYALRTGAFEPAEASVNPQD--LQGSLQELKERALSRYNLVRGQGPER 343
Query: 281 FFNKEGDFNN-LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAIN 339
+ DF L + A KK +TG + I + P+ ++ S S D+SI
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF-DKSIK----- 397
Query: 340 SSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKV 399
+W+ ++ Y+ +GH ++ +A+S D + +V+G D +KV
Sbjct: 398 -----------------LWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKV 440
Query: 400 WNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVR 440
W+ + + H+ V V ++ G V + D +R
Sbjct: 441 WDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLR 481
Score = 56.6 bits (135), Expect = 1e-07
Identities = 34/99 (34%), Positives = 44/99 (44%), Gaps = 10/99 (10%)
Query: 492 RLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSD-----A 546
R L GH + + F+P LAS S D TVR WD+ + ET T
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDL-----STETPHFTCKGHRHWV 159
Query: 547 LAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRH 585
L++++ PDG +LA N QI WDP Q G H
Sbjct: 160 LSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGH 198
Score = 55.5 bits (132), Expect = 2e-07
Identities = 48/183 (26%), Positives = 82/183 (44%), Gaps = 9/183 (4%)
Query: 407 CFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAV 466
C + HS V V F+ TG + + S D TVR +DL T R S ++
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLS-ISW 164
Query: 467 DASGEIVSAGAQDSFEIFVWSMQTGRLLD-VLSGHEGPISGLCFNPMKS-----VLASAS 520
G +++G ++ +I +W TG+ + L+GH I+GL + P+ + +AS+S
Sbjct: 165 SPDGRKLASGCKNG-QILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSS 223
Query: 521 WDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGS 580
D +VR+WD + T + + DG L A+ + I W + V +
Sbjct: 224 KDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLCRT 282
Query: 581 IEG 583
++G
Sbjct: 283 LQG 285
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 79.0 bits (193), Expect = 2e-14
Identities = 66/267 (24%), Positives = 121/267 (45%), Gaps = 16/267 (5%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH + + + S DGQ+ ++G DG +++W+ +G F H+ V V F++
Sbjct: 60 RGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQ 119
Query: 430 VVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCV--AVDASGEIVSAGAQDSFEIFVWS 487
+V+ S D T++ ++ + SCV + ++S I+ + D + VW+
Sbjct: 120 IVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL-VKVWN 178
Query: 488 MQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDAL 547
+ +L GH G ++ + +P S+ AS D LWD+ + + TL
Sbjct: 179 LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL-NEGKHLYTLDGGDIIN 237
Query: 548 AVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKA 607
A+ F P+ L AT I WD +EG+ + ++E+ I+ A+
Sbjct: 238 ALCFSPNRYWLCAAT-GPSIKIWD---------LEGKIIVDELKQEV--ISTSSKAEPPQ 285
Query: 608 FTALCYSADGHSILAGGMSKFVCIYHV 634
T+L +SADG ++ AG V ++ V
Sbjct: 286 CTSLAWSADGQTLFAGYTDNLVRVWQV 312
Score = 77.8 bits (190), Expect = 4e-14
Identities = 55/202 (27%), Positives = 106/202 (52%), Gaps = 10/202 (4%)
Query: 333 IASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGG 392
++ V I+S G + G S G L +W+ + + + GH ++++A+S D + IV+G
Sbjct: 66 VSDVVISSDGQFALSG-SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124
Query: 393 DDGKVKVWNTLSGFCFVTFTE--HSSGVTGVTFT--ATGYVVVTSSMDGTVRAFDLHRYR 448
D +K+WNTL G C T + HS V+ V F+ ++ ++V+ D V+ ++L +
Sbjct: 125 RDKTIKLWNTL-GVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183
Query: 449 NFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLC 508
+T + V V G + ++G +D + +W + G+ L L G + I+ LC
Sbjct: 184 -LKTNHIGHTGYLNTVTVSPDGSLCASGGKDG-QAMLWDLNEGKHLYTLDGGD-IINALC 240
Query: 509 FNPMKSVLASASWDKTVRLWDM 530
F+P + L +A+ ++++WD+
Sbjct: 241 FSPNRYWLCAAT-GPSIKIWDL 261
Score = 46.2 bits (108), Expect = 1e-04
Identities = 22/75 (29%), Positives = 35/75 (46%)
Query: 497 LSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGA 556
L GH +S + + S SWD T+RLWD+ T+ + T D L+V F D
Sbjct: 59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR 118
Query: 557 ELAVATLNSQITFWD 571
++ + + I W+
Sbjct: 119 QIVSGSRDKTIKLWN 133
Score = 35.8 bits (81), Expect = 0.19
Identities = 60/265 (22%), Positives = 92/265 (34%), Gaps = 49/265 (18%)
Query: 183 ALGGHKDAIVACFFESNSLDLYSLSQDGVLCMWQCDTPPEGLRLKPPAGWKADLLQREEE 242
AL GH + S+ S S DG L +W T G + G D+L
Sbjct: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT---GTTTRRFVGHTKDVLSVAFS 114
Query: 243 EEEEEDQEGDRETTIR-------GKATPAEEEKTGKVKYSRLA----------------- 278
+ + G R+ TI+ K T +E + V R +
Sbjct: 115 SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLV 174
Query: 279 --------KYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISD 330
K N G L L +G G L +L E +++L D
Sbjct: 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD 234
Query: 331 QSIASVAINSSGDWIAFGCSGLG-QLLVWEWQSESYV--LKQQGHFNSMVA-------LA 380
I ++ + + W+ C+ G + +W+ + + V LKQ+ S A LA
Sbjct: 235 -IINALCFSPNRYWL---CAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLA 290
Query: 381 YSPDGQYIVTGGDDGKVKVWNTLSG 405
+S DGQ + G D V+VW G
Sbjct: 291 WSADGQTLFAGYTDNLVRVWQVTIG 315
Score = 31.2 bits (69), Expect = 4.6
Identities = 30/131 (22%), Positives = 52/131 (39%), Gaps = 2/131 (1%)
Query: 37 VTVFDLKNNKSDTLPLATRYNVKCVGLSPDGRLAIIVDEGGDALLVSLVCRSVLHHFHFK 96
V V++L N K T + + V +SPDG L + G A+L L L+
Sbjct: 174 VKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGG 233
Query: 97 GSVHSVSFSPDGRKFVVTKGNIAQMYHAPGK--KREFNAFVLDKTYFGPYDETTCIDWTD 154
++++ FSP+ G +++ GK E V+ + + T + W+
Sbjct: 234 DIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSA 293
Query: 155 DSRCFVVGSKD 165
D + G D
Sbjct: 294 DGQTLFAGYTD 304
Score = 30.4 bits (67), Expect = 7.9
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 58 VKCVGLSPDGRLAIIVDEGGDALLV---SLVCRSVLHHFHFKGSVHSVSFSPDG 108
V CV SP+ IIV G D L+ C+ +H G +++V+ SPDG
Sbjct: 151 VSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDG 204
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 78.6 bits (192), Expect = 3e-14
Identities = 72/331 (21%), Positives = 132/331 (39%), Gaps = 67/331 (20%)
Query: 258 RGKATPAE-EEKTGKVKYSRLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHE 316
RGKA + EE+ + SR K+ G +++ A F LVTG G +
Sbjct: 188 RGKAAVKDVEEEKFPTQLSRHIKF-----GQKSHVECARFSPDGQYLVTGSVDGFIEVWN 242
Query: 317 LP--------EFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLK 368
++ + + D ++ + + + +A G G++ VW+ QS + +
Sbjct: 243 FTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQD-GKIKVWKIQSGQCLRR 301
Query: 369 -QQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG 427
++ H + L++S D I++ D +++ SG F HSS V TFT G
Sbjct: 302 FERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDG 361
Query: 428 YVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPT---------------------------- 459
+ ++++S DGTV+ +++ TF S T
Sbjct: 362 HYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNT 421
Query: 460 ----------------------QFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVL 497
F C A+ GE + +D F ++ +S TG+L L
Sbjct: 422 VVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGED-FVLYCFSTVTGKLERTL 480
Query: 498 SGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
+ HE + G+ +P ++++A+ S D ++LW
Sbjct: 481 TVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
Score = 64.3 bits (155), Expect = 5e-10
Identities = 42/159 (26%), Positives = 73/159 (45%), Gaps = 11/159 (6%)
Query: 381 YSPDGQYIVTGGDDGKVKVWNTLSGFCFV--------TFTEHSSGVTGVTFTATGYVVVT 432
+SPDGQY+VTG DG ++VWN +G F V + F+ ++ T
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 433 SSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDA-SGEIVSAGAQDSFEIFVWSMQTG 491
+ DG ++ + + + R F +C++ S +I+SA + I +++G
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH--GLKSG 339
Query: 492 RLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDM 530
+ L GH ++ F + SAS D TV++W+M
Sbjct: 340 KTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/164 (25%), Positives = 72/164 (43%), Gaps = 9/164 (5%)
Query: 416 SGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFS-------CVAVDA 468
S V F+ G +VT S+DG + ++ + + F C+
Sbjct: 215 SHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSR 274
Query: 469 SGEIVSAGAQDSFEIFVWSMQTGRLLDVLS-GHEGPISGLCFNPMKSVLASASWDKTVRL 527
E+++ GAQD +I VW +Q+G+ L H ++ L F+ S + SAS+D+T+R+
Sbjct: 275 DTEMLATGAQDG-KIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRI 333
Query: 528 WDMFDSWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ KE +S TF DG + A+ + + W+
Sbjct: 334 HGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 77.4 bits (189), Expect = 6e-14
Identities = 94/392 (23%), Positives = 145/392 (36%), Gaps = 46/392 (11%)
Query: 233 KADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYSRLAKYFFNKEGDFNNLT 292
K D + +E E Q+G RE + K + T ++ + N +L+
Sbjct: 277 KVDHSREKENAPEGPTQKGLREAREQNKCKTKMKGNTKDSEFPIDMQPNPNLNVSKESLS 336
Query: 293 AAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGL 352
A F K IF LHELP + +S+ V+ W G
Sbjct: 337 PAKFDYK--------LKNIFRLHELP----VSCVSMQPHKDILVSCGEDRLWKVLGLPKC 384
Query: 353 GQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFT 412
LL GH + + + P G + T D VK+W+ G C +TF
Sbjct: 385 NVLLTGF-----------GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFE 433
Query: 413 EHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEI 472
HS V T+ + G V +SS+D T + +D++ R T + S S +
Sbjct: 434 GHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTL 493
Query: 473 VSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFD 532
+++ A + I W +TG L GH I+ F+P ++AS +LWD
Sbjct: 494 LTSSADKTLSI--WDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRK 551
Query: 533 SWRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRK 592
S V F G LA A+ N I DLK+G
Sbjct: 552 LLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLL---------------DLKSG-- 594
Query: 593 ELDKITAKHAAKGKAFTALCYSADGHSILAGG 624
E+ K+ + +A T + +S DG + +GG
Sbjct: 595 EIHKLMGH---ENEAHTVV-FSHDGEILFSGG 622
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 6/239 (2%)
Query: 291 LTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCS 350
L+ FH L T L +L + + I + +++ S +S G+++A S
Sbjct: 397 LSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA--SS 454
Query: 351 GLGQLL-VWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFV 409
L + +W+ SE GH +S+ ++ + P ++T D + +W+ +G C
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
Query: 410 TFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDAS 469
+ H + F G+++ + G + +D + + P+ + V D+S
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIG-PSPGNEVNFDSS 573
Query: 470 GEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLW 528
G ++ A A + I + +++G + L GHE + F+ +L S D TVR W
Sbjct: 574 GRVL-AQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 48.5 bits (114), Expect = 3e-05
Identities = 32/116 (27%), Positives = 57/116 (49%), Gaps = 2/116 (1%)
Query: 286 GDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWI 345
G +++ A F + H++ + A G+ L + + I S+ I V +SSG +
Sbjct: 518 GHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVL 577
Query: 346 AFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
A SG G + + + +S + K GH N + +S DG+ + +GG DG V+ W+
Sbjct: 578 A-QASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 77.4 bits (189), Expect = 6e-14
Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 10/206 (4%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+GH ++ +L SP+G+ + T D + +WN + H VT V F+ G +
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL 74
Query: 430 VVTSSMDGTVRAF---DLHRYRNFRTFTSP-RPTQFSCVAVDASGEIVSAGAQDSFEIFV 485
+ ++S D TVR + ++ F+ T+P R FS A G+ ++ ++D I V
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFS-----ADGQFLATASEDK-SIKV 128
Query: 486 WSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSD 545
WSM R L L H + F+P ++ S S DKT+++WD +
Sbjct: 129 WSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 546 ALAVTFRPDGAELAVATLNSQITFWD 571
A V F P G +A A + + WD
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWD 214
Score = 77.4 bits (189), Expect = 6e-14
Identities = 49/218 (22%), Positives = 103/218 (47%), Gaps = 4/218 (1%)
Query: 355 LLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEH 414
L++W ++ + + GH + + ++ +SP G + + D V++W F F H
Sbjct: 42 LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAH 101
Query: 415 SSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQF-SCVAVDASGEIV 473
++ V V F+A G + T+S D +++ + ++R R ++ R T + C G ++
Sbjct: 102 TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFL--YSLYRHTHWVRCAKFSPDGRLI 159
Query: 474 SAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDS 533
+ ++D I +W + ++ S G + + FNP + +ASA D+TV++WD+ +
Sbjct: 160 VSCSEDK-TIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 534 WRTKETLALTSDALAVTFRPDGAELAVATLNSQITFWD 571
+ + ++F P G L A+ + + D
Sbjct: 219 KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256
Score = 74.3 bits (181), Expect = 5e-13
Identities = 46/196 (23%), Positives = 87/196 (44%), Gaps = 3/196 (1%)
Query: 333 IASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGG 392
+ SV ++ G ++A + VW + ++ H + + +SPDG+ IV+
Sbjct: 105 VRSVDFSADGQFLATASEDKS-IKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCS 163
Query: 393 DDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHRYRNFRT 452
+D +K+W+T + C F++ V F +G + ++ D TV+ +D+ R
Sbjct: 164 EDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV-RVNKLLQ 222
Query: 453 FTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFNPM 512
+C++ SG + + D + + + GRL+ L GH GP+ + F+
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDG-TLKILDLLEGRLIYTLQGHTGPVFTVSFSKG 281
Query: 513 KSVLASASWDKTVRLW 528
+ AS D V LW
Sbjct: 282 GELFASGGADTQVLLW 297
Score = 72.4 bits (176), Expect = 2e-12
Identities = 46/201 (22%), Positives = 90/201 (44%), Gaps = 2/201 (0%)
Query: 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYV 429
+ H + ++ +S DGQ++ T +D +KVW+ + H+ V F+ G +
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 430 VVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQ 489
+V+ S D T++ +D + F S + V + SG +++ D + VW ++
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNF-SDSVGFANFVDFNPSGTCIASAGSDQ-TVKVWDVR 216
Query: 490 TGRLLDVLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAV 549
+LL H G ++ + F+P + L +AS D T+++ D+ + T V
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV 276
Query: 550 TFRPDGAELAVATLNSQITFW 570
+F G A ++Q+ W
Sbjct: 277 SFSKGGELFASGGADTQVLLW 297
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/75 (30%), Positives = 35/75 (46%)
Query: 499 GHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAEL 558
GH+ I+ L +P LA+ASWD + LW+ R + +V F P G L
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 559 AVATLNSQITFWDPE 573
A A+ + + W P+
Sbjct: 76 ASASRDRTVRLWIPD 90
Score = 41.2 bits (95), Expect = 0.004
Identities = 59/307 (19%), Positives = 105/307 (34%), Gaps = 67/307 (21%)
Query: 96 KGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGKKREFNAFVLDKTYFGPYDETTCIDWTDD 155
K V SV FSP G + P K+ +F+ F K + P +D++ D
Sbjct: 60 KDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF---KAHTAP---VRSVDFSAD 113
Query: 156 SRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVACFFESNSLDLYSLSQDGVLCMW 215
+ S+D S V+ R L Y+L H + F + + S S+D + +W
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFL--YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 216 QCDTPPEGLRLKPPAGWKADLLQREEEEEEEEDQEGDRETTIRGKATPAEEEKTGKVKYS 275
G+ + + + T A + K V+ +
Sbjct: 172 DTTNKQCVNNFSDSVGFANFV-------------DFNPSGTCIASAGSDQTVKVWDVRVN 218
Query: 276 RLAKYFFNKEGDFNNLTAAAFHKKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIAS 335
+L +++ G N ++ FH + L+T + G + +L E LI++L
Sbjct: 219 KLLQHYQVHSGGVNCIS---FHPSGNYLITASSDGTLKILDLLEGRLIYTL--------- 266
Query: 336 VAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDG 395
QGH + +++S G+ +GG D
Sbjct: 267 ----------------------------------QGHTGPVFTVSFSKGGELFASGGADT 292
Query: 396 KVKVWNT 402
+V +W T
Sbjct: 293 QVLLWRT 299
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/266 (24%), Positives = 108/266 (40%), Gaps = 18/266 (6%)
Query: 329 SDQSIASVAINSSGDWIAFGC-SGLGQLLVWEWQSESYVLKQQG-HFNSMVALAYSPDGQ 386
S++ + S+ NS G +A G G ++ W + G H + AL ++ G
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARI----WTENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 387 YIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHR 446
Y+++ G D +W+ +G F HS+ V + + S D + L
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGC 348
Query: 447 YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHE----- 501
+TF + + + D SG ++ A D + +WSM+ + L H
Sbjct: 349 DHPVKTFQG-HTNEVNAIKWDPSGMLL-ASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 502 ---GPISGLCFNPMKSV-LASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAE 557
P NP S+ LASAS+D TVRLWD+ T + +V F PDG
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 558 LAVATLNSQITFWDPENAVQTGSIEG 583
LA + + + W+ ++ S +G
Sbjct: 467 LASGSFDKYVHIWNTQSGSLVHSYQG 492
Score = 67.0 bits (162), Expect = 8e-11
Identities = 68/334 (20%), Positives = 130/334 (38%), Gaps = 54/334 (16%)
Query: 337 AINSSGDWIAFGCSGLGQLLVWEWQSES----------YVLKQQGHF----NSMVALAYS 382
A N D +A G SG +W S + +++ GH + +L ++
Sbjct: 186 AWNPVSDLLASG-SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 244
Query: 383 PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAF 442
DG + G DG ++W T +G T +H + + + G V+++ +D T +
Sbjct: 245 SDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 443 DLHR---YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSG 499
D H + F ++P + VD + A I V + + G
Sbjct: 304 DAHTGEAKQQFPFHSAP------ALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG 357
Query: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAE-- 557
H ++ + ++P +LAS S D T+++W M + A + + + + P G
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATS 417
Query: 558 -------LAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTA 610
LA A+ +S + WD E V T ++ KH + +
Sbjct: 418 NPNSSIMLASASFDSTVRLWDVEQGVCTHTL-----------------MKHQ---EPVYS 457
Query: 611 LCYSADGHSILAGGMSKFVCIYHVREQILMKRFE 644
+ +S DG + +G K+V I++ + L+ ++
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ 491
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/158 (24%), Positives = 68/158 (43%), Gaps = 9/158 (5%)
Query: 496 VLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG 555
VL GHE + +NP+ +LAS S D T R+W++ ++ T + +
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 556 AELAVATLNSQITFWDPENA-VQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYS 614
+ V +L+ W+ + + GS +G + T L +H KG F AL ++
Sbjct: 234 SNKDVTSLD-----WNSDGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIF-ALKWN 285
Query: 615 ADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLD 652
G+ +L+ G+ K I+ ++F +LD
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/266 (24%), Positives = 108/266 (40%), Gaps = 18/266 (6%)
Query: 329 SDQSIASVAINSSGDWIAFGC-SGLGQLLVWEWQSESYVLKQQG-HFNSMVALAYSPDGQ 386
S++ + S+ NS G +A G G ++ W + G H + AL ++ G
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARI----WTENGNLASTLGQHKGPIFALKWNKKGN 289
Query: 387 YIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAFDLHR 446
Y+++ G D +W+ +G F HS+ V + + S D + L
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGC 348
Query: 447 YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHE----- 501
+TF + + + D SG ++ A D + +WSM+ + L H
Sbjct: 349 DHPVKTFQG-HTNEVNAIKWDPSGMLL-ASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 502 ---GPISGLCFNPMKSV-LASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAE 557
P NP S+ LASAS+D TVRLWD+ T + +V F PDG
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKY 466
Query: 558 LAVATLNSQITFWDPENAVQTGSIEG 583
LA + + + W+ ++ S +G
Sbjct: 467 LASGSFDKYVHIWNTQSGSLVHSYQG 492
Score = 67.0 bits (162), Expect = 8e-11
Identities = 68/334 (20%), Positives = 130/334 (38%), Gaps = 54/334 (16%)
Query: 337 AINSSGDWIAFGCSGLGQLLVWEWQSES----------YVLKQQGHF----NSMVALAYS 382
A N D +A G SG +W S + +++ GH + +L ++
Sbjct: 186 AWNPVSDLLASG-SGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWN 244
Query: 383 PDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATGYVVVTSSMDGTVRAF 442
DG + G DG ++W T +G T +H + + + G V+++ +D T +
Sbjct: 245 SDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIW 303
Query: 443 DLHR---YRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGRLLDVLSG 499
D H + F ++P + VD + A I V + + G
Sbjct: 304 DAHTGEAKQQFPFHSAP------ALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQG 357
Query: 500 HEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDGAE-- 557
H ++ + ++P +LAS S D T+++W M + A + + + + P G
Sbjct: 358 HTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATS 417
Query: 558 -------LAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTA 610
LA A+ +S + WD E V T ++ KH + +
Sbjct: 418 NPNSSIMLASASFDSTVRLWDVEQGVCTHTL-----------------MKHQ---EPVYS 457
Query: 611 LCYSADGHSILAGGMSKFVCIYHVREQILMKRFE 644
+ +S DG + +G K+V I++ + L+ ++
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQ 491
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/158 (24%), Positives = 68/158 (43%), Gaps = 9/158 (5%)
Query: 496 VLSGHEGPISGLCFNPMKSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG 555
VL GHE + +NP+ +LAS S D T R+W++ ++ T + +
Sbjct: 174 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVP 233
Query: 556 AELAVATLNSQITFWDPENA-VQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYS 614
+ V +L+ W+ + + GS +G + T L +H KG F AL ++
Sbjct: 234 SNKDVTSLD-----WNSDGTLLAMGSYDGFARIWTENGNLASTLGQH--KGPIF-ALKWN 285
Query: 615 ADGHSILAGGMSKFVCIYHVREQILMKRFEISCNLSLD 652
G+ +L+ G+ K I+ ++F +LD
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALD 323
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,387,120
Number of Sequences: 37866
Number of extensions: 1614666
Number of successful extensions: 14362
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 157
Number of HSP's that attempted gapping in prelim test: 10562
Number of HSP's gapped (non-prelim): 2520
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.