Search of human proteins with 48526516

Search of human proteins with 48526516

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48526516 solute carrier family 22, member 23 isoform b [Homo
sapiens]
         (405 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170650643 solute carrier family 22, member 23 isoform a [Homo...   816   0.0  
gi|48526516 solute carrier family 22, member 23 isoform b [Homo ...   816   0.0  
gi|21361834 solute carrier family 22, member 17 isoform a [Homo ...   213   2e-55
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   213   3e-55
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   208   8e-54
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   204   1e-52
gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo sap...   101   1e-21
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]           93   5e-19
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]        91   1e-18
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...    91   2e-18
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]        89   7e-18
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...    89   7e-18
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...    84   3e-16
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...    84   3e-16
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]           83   4e-16
gi|166064021 solute carrier family 22 (organic anion transporter...    81   1e-15
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]           80   4e-15
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]        77   4e-14
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]           77   4e-14
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...    76   5e-14
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]            76   5e-14
gi|42542386 solute carrier family 22 (organic anion/cation trans...    75   1e-13
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]           74   2e-13
gi|157426885 organic cation transporter like 4 [Homo sapiens]          72   1e-12
gi|4507001 solute carrier family 22 member 2 [Homo sapiens]            70   3e-12
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...    69   8e-12
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...    69   8e-12
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]           66   6e-11
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...    60   4e-09
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]        59   6e-09

>gi|170650643 solute carrier family 22, member 23 isoform a [Homo
           sapiens]
          Length = 686

 Score =  816 bits (2109), Expect = 0.0
 Identities = 405/405 (100%), Positives = 405/405 (100%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD
Sbjct: 282 MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 341

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 120
           WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV
Sbjct: 342 WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 401

Query: 121 IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL 180
           IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL
Sbjct: 402 IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL 461

Query: 181 LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
           LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS
Sbjct: 462 LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 521

Query: 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF 300
           QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF
Sbjct: 522 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF 581

Query: 301 GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL 360
           GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL
Sbjct: 582 GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL 641

Query: 361 LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM 405
           LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM
Sbjct: 642 LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM 686


>gi|48526516 solute carrier family 22, member 23 isoform b [Homo
           sapiens]
          Length = 405

 Score =  816 bits (2109), Expect = 0.0
 Identities = 405/405 (100%), Positives = 405/405 (100%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD
Sbjct: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 120
           WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV
Sbjct: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 120

Query: 121 IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL 180
           IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL
Sbjct: 121 IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL 180

Query: 181 LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240
           LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS
Sbjct: 181 LENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYS 240

Query: 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF 300
           QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF
Sbjct: 241 QHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGF 300

Query: 301 GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL 360
           GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL
Sbjct: 301 GMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPL 360

Query: 361 LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM 405
           LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM
Sbjct: 361 LPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM 405


>gi|21361834 solute carrier family 22, member 17 isoform a [Homo
           sapiens]
          Length = 538

 Score =  213 bits (542), Expect = 2e-55
 Identities = 134/392 (34%), Positives = 201/392 (51%), Gaps = 38/392 (9%)

Query: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64
           LRF  GF LAG+ L +Y +R+ELC P +R  + +    V + G FL  GLA + +DW+ L
Sbjct: 157 LRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFL 216

Query: 65  QALIICPFLLMLLY-W-SIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIP 122
           Q +I  P +L L Y W  +F ES RWL+  +Q E A+ ++    ++NR  P G + G   
Sbjct: 217 QRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNR--PHGQMLG--- 271

Query: 123 ELEKELSRRPKKVC---------IVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMG 173
           E  +E  +  +  C            ++  RN+WKN+++L   +   + I HC+     G
Sbjct: 272 EEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGG 331

Query: 174 HEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLL 233
                    +FY      +  A ++C+ + V V   GRRG LLL M LT +ASL+ LGL 
Sbjct: 332 GSPS-----DFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLW 386

Query: 234 NLIGKYSQHP--------DSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTV 285
           +      +HP            +  + +     FS++G+F+S A   LS    AE+ PT 
Sbjct: 387 DC-----EHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTT 441

Query: 286 IRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNL 345
           +R  GLGL++A    G L+ P   LH   G FL H++ A C L+CI+ I+LLPE++ + L
Sbjct: 442 VRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLL 501

Query: 346 PENISNGEHYTRQPLL----PHKKGEQPLLLT 373
           PE + +GE   R  LL    P +    PLL T
Sbjct: 502 PEVLRDGELCRRPSLLRQPPPTRCDHVPLLAT 533


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  213 bits (541), Expect = 3e-55
 Identities = 133/384 (34%), Positives = 197/384 (51%), Gaps = 40/384 (10%)

Query: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64
           LRF  GF LAG+ L +Y +R+ELC P +R  + +    V + G FL  GLA + +DW+ L
Sbjct: 157 LRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFL 216

Query: 65  QALIICPFLLMLLY-W-SIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIP 122
           Q +I  P +L L Y W  +F ES RWL+  +Q E A+ ++    ++NR  P G + G   
Sbjct: 217 QRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNR--PHGQMLG--- 271

Query: 123 ELEKELSRRPKKVC---------IVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMG 173
           E  +E  +  +  C            ++  RN+WKN+++L   +   + I HC+     G
Sbjct: 272 EEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGG 331

Query: 174 HEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLL 233
                    +FY      +  A ++C+ + V V   GRRG LLL M LT +ASL+ LGL 
Sbjct: 332 GSPS-----DFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLW 386

Query: 234 NLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGL 293
                          D + +     FS++G+F+S A   LS    AE+ PT +R  GLGL
Sbjct: 387 ---------------DYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGL 431

Query: 294 VLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGE 353
           ++A    G L+ P   LH   G FL H++ A C L+CI+ I+LLPE++ + LPE + +GE
Sbjct: 432 IMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGE 491

Query: 354 HYTRQPLL----PHKKGEQPLLLT 373
              R  LL    P +    PLL T
Sbjct: 492 LCRRPSLLRQPPPTRCDHVPLLAT 515


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  208 bits (529), Expect = 8e-54
 Identities = 127/367 (34%), Positives = 196/367 (53%), Gaps = 31/367 (8%)

Query: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 186 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 245

Query: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 246 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 305

Query: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI   F RS+   
Sbjct: 306 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRRSL--- 362

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234
               P +  FY  Y+  A +   + + + +     GRR  LLL  ++T LASLL L    
Sbjct: 363 ---APQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 419

Query: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294
            +  ++                +  S++G+ AS AV +LS  F AE+ PTVIR  GLGLV
Sbjct: 420 YLPGWTV---------------LFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLV 464

Query: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEH 354
           L +   G    P+  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+++ + + 
Sbjct: 465 LGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 524

Query: 355 YTRQPLL 361
             R PLL
Sbjct: 525 LRRSPLL 531


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  204 bits (519), Expect = 1e-52
 Identities = 126/367 (34%), Positives = 195/367 (53%), Gaps = 31/367 (8%)

Query: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 188 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 247

Query: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 248 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 307

Query: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI   F RS+   
Sbjct: 308 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFRRSL--- 364

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234
               P +  FY  Y+  A +   + + + +     GRR  LLL  ++T LASLL L    
Sbjct: 365 ---APQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 421

Query: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294
            +  ++                +  S++G+ AS AV +LS  F AE+ PTVIR  GLGLV
Sbjct: 422 YLPGWTV---------------LFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLV 466

Query: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEH 354
           L +   G     +  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+++ + + 
Sbjct: 467 LGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 526

Query: 355 YTRQPLL 361
             R PLL
Sbjct: 527 LRRSPLL 533


>gi|239756672 PREDICTED: hypothetical protein LOC146429 [Homo
           sapiens]
          Length = 495

 Score =  101 bits (251), Expect = 1e-21
 Identities = 84/278 (30%), Positives = 131/278 (47%), Gaps = 34/278 (12%)

Query: 5   LRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVL 64
           LR   G  LAG +L LY  R+ELC P  R   +M A   ++ G  L+PGLAAL +DW++L
Sbjct: 186 LRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLL 245

Query: 65  QALIICPFLLMLLYW---SIFPESLRWLMATQQFESAKRLILHFTQKNRMNP-----EGD 116
           Q L      L+LL+W   ++FPES  WL+AT Q   A++++  F + + + P     E +
Sbjct: 246 QGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLEEN 305

Query: 117 IKGVIPELEKELSR--RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGH 174
                 EL    +R  +P+    + ++ TR  W+N ++L  +SL G GI      ++ G 
Sbjct: 306 SLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIR----ANLPGW 361

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVR-----------FLGRRGGLL------- 216
            V    +    A    +A  +L +      V+R           FLG+  GLL       
Sbjct: 362 TVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGLLDTLHGRQ 421

Query: 217 -LFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKD 253
             F+     ASL  L LL ++    +    G+  S++D
Sbjct: 422 GFFLQQVVFASLAVLALLCVL-LLPESRSRGLPQSLQD 458



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 50/134 (37%), Positives = 79/134 (58%), Gaps = 7/134 (5%)

Query: 228 LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIR 287
           L LG  +L+G        G+  ++     +  S++G+ AS AV +LS  F AE+ PTVIR
Sbjct: 342 LILGFSSLVG-------GGIRANLPGWTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIR 394

Query: 288 CGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347
             GLGLVL +   G     +  LH ++G+FL  ++FA   ++ ++C+LLLPESR + LP+
Sbjct: 395 GAGLGLVLGAGFLGQAAGLLDTLHGRQGFFLQQVVFASLAVLALLCVLLLPESRSRGLPQ 454

Query: 348 NISNGEHYTRQPLL 361
           ++ + +   R PLL
Sbjct: 455 SLQDADRLRRSPLL 468


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score = 92.8 bits (229), Expect = 5e-19
 Identities = 90/375 (24%), Positives = 166/375 (44%), Gaps = 35/375 (9%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   RF  GF ++GI L+   L +E  P   R +++    +    GQF++PGLA     
Sbjct: 175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQ 234

Query: 61  WQVLQALIICPFLLMLL--YWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGD-- 116
           W+ LQ  +  PF +  L  +W+  PES+RWL+ + +   A +++      N    EG+  
Sbjct: 235 WRWLQLTVSIPFFVFFLSSWWT--PESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERL 292

Query: 117 -IKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHE 175
            ++ +   L+KE+S    K     +     L +  +  C+ SL  +     +    MG E
Sbjct: 293 SLEELKLNLQKEISLAKAKYTASDLFRIPMLRR--MTFCL-SLAWFATGFAYYSLAMGVE 349

Query: 176 ---VKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGL 232
              V + +L+  +      A    +  L+      +LGR       ++L   A L     
Sbjct: 350 EFGVNLYILQIIFGGVDVPAKFITILSLS------YLGRHTTQAAALLLAGGAIL----A 399

Query: 233 LNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG 292
           L  +    Q   + ++   K   S +FS + ++ S            E+ PTVIR  G+G
Sbjct: 400 LTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTS------------ELYPTVIRQTGMG 447

Query: 293 LVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNG 352
           +       G + +P++++  +   F+ +II+    L+     L LPE+ +Q LPE I + 
Sbjct: 448 VSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDL 507

Query: 353 EHYTRQPLLPHKKGE 367
           E+++ +   P ++ E
Sbjct: 508 ENWSLRAKKPKQEPE 522


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 91/362 (25%), Positives = 160/362 (44%), Gaps = 35/362 (9%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRI-ELCPPGKRFMITMVASFVAMAGQFLMPGLAALCR 59
           ++  LRF  GF  + II++  +L I E   P  + ++ +++S     GQ ++ GLA + R
Sbjct: 198 VYCVLRFLAGFS-SMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFR 256

Query: 60  DWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRM-NPEG--D 116
           DWQ L  +   PF +  L      ES RWL+ T + +   + +    + N + N E   +
Sbjct: 257 DWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRKVARTNGIKNAEETLN 316

Query: 117 IKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLC----VNSLTGYGIHHCFARSMM 172
           I+ V   +++EL     K  +  +    ++ K I +L      N++  YG       ++ 
Sbjct: 317 IEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGT----MVNLQ 372

Query: 173 GHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGL 232
                + LL+  Y      A   +V CLA+ + +  +GRR   +LFM L  L+ L     
Sbjct: 373 HVGSNIFLLQVLYG-----AVALIVRCLAL-LTLNHMGRRISQILFMFLVGLSILAN--- 423

Query: 233 LNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLG 292
              + K  Q               +A + +G+  S A  S       E+ PTV+R    G
Sbjct: 424 -TFVPKEMQ------------TLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASG 470

Query: 293 LVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNG 352
           + L ++  G   AP++         L  II+    +I  + + LLPE+++  LP+ I + 
Sbjct: 471 IDLTASRIGAALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDV 530

Query: 353 EH 354
           E+
Sbjct: 531 EN 532


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 81/389 (20%), Positives = 165/389 (42%), Gaps = 31/389 (7%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   R   G  LAGI L    L +E  P   R  +  +  +V   GQFL+ G+A     
Sbjct: 187 IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH 246

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEG---DI 117
           W+ LQ L+  PF    +Y   F ES RW  ++ + +   R +    + N    EG    +
Sbjct: 247 WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSM 306

Query: 118 KGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL---TGYGIHHCFARSMMGH 174
           + +   L+KEL+    +   ++++    L    + LC++ L   T +  ++     + G 
Sbjct: 307 EVLRASLQKELTMGKGQASAMELLRCPTL--RHLFLCLSMLWFATSFA-YYGLVMDLQGF 363

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234
            V + L++  +       ++ L + L   +V+  LGRR   +  ++L  +  LL      
Sbjct: 364 GVSIYLIQVIF------GAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL------ 411

Query: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294
                     +G+    +     + +++G     A  +    +  E+ PT+IR  G+G+ 
Sbjct: 412 ----------NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMG 461

Query: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEH 354
              A  G + +P++ +  +    +   I+    +      +LLPE+  Q LP+ + + E 
Sbjct: 462 STMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES 521

Query: 355 YTRQPLLPHKKGEQPLLLTNAELKDYSGL 383
              +     ++ ++ ++   A  ++ +GL
Sbjct: 522 RKGKQTRQQQEHQKYMVPLQASAQEKNGL 550


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 83/360 (23%), Positives = 150/360 (41%), Gaps = 25/360 (6%)

Query: 2   FSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDW 61
           +   RF  G   +GIIL   +L +E  P   R +  ++  +    GQ ++ G+A L R W
Sbjct: 190 YCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILAGVAYLIRPW 249

Query: 62  QVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVI 121
           + LQ  I  PFL+  LY    PES RWL+   + + A + +      N    EG+     
Sbjct: 250 RCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRKEEGE----- 304

Query: 122 PELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLL 181
             L KE+     +     V  + ++        +  +T   +   F+ S+  + + + L 
Sbjct: 305 -RLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAMDLQ 363

Query: 182 ENFYADYYTTASIALVSCLAMCVVVR---FLGRRGGLLLFMILTALASLLQLGLLNLIGK 238
           +   + Y   A   +++  AM V      ++GRR  +  F+IL  L  +  +     + +
Sbjct: 364 KFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANM----FVPE 419

Query: 239 YSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASA 298
            +Q   +  +   K   + +F  V +F              E+ PT IR  G+G     A
Sbjct: 420 GTQILCTAQAALGKGCLASSFICVYLFT------------GELYPTEIRQMGMGFASVHA 467

Query: 299 GFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQ 358
             G LTAP++    +    L  + F    ++  + + +L E+R+  L E I+  E   ++
Sbjct: 468 RLGGLTAPLVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKE 527


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 78/359 (21%), Positives = 152/359 (42%), Gaps = 31/359 (8%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   R   G  LAGI L    L +E  P   R  +  +  +V   GQFL+ G+A     
Sbjct: 187 IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH 246

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEG---DI 117
           W+ LQ L+  PF    +Y   F ES RW  ++ + +   R +    + N    EG    +
Sbjct: 247 WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSM 306

Query: 118 KGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL---TGYGIHHCFARSMMGH 174
           + +   L+KEL+    +   ++++    L    + LC++ L   T +  ++     + G 
Sbjct: 307 EVLRASLQKELTMGKGQASAMELLRCPTL--RHLFLCLSMLWFATSFA-YYGLVMDLQGF 363

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN 234
            V + L++  +       ++ L + L   +V+  LGRR   +  ++L  +  LL      
Sbjct: 364 GVSIYLIQVIF------GAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL------ 411

Query: 235 LIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLV 294
                     +G+    +     + +++G     A  +    +  E+ PT+IR  G+G+ 
Sbjct: 412 ----------NGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMG 461

Query: 295 LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGE 353
              A  G + +P++ +  +    +   I+    +      +LLPE+  Q LP+ + + E
Sbjct: 462 STMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLE 520


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 94/363 (25%), Positives = 149/363 (41%), Gaps = 41/363 (11%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           MF+  R   G  LAG  + +  L +E      R +  +++S     G  L+  +  L RD
Sbjct: 197 MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRD 256

Query: 61  WQVLQALIICPFL--LMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKN-------RM 111
           W+ L   +  P    ++ L+W   PES RWL+     + A R +LH  + N         
Sbjct: 257 WRWLLLAVTLPCAPGILSLWW--VPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSF 314

Query: 112 NPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSM 171
           + E   K    E    + RRP  + + +    R+    I + CV  +  +G++     S 
Sbjct: 315 SQEAVSKVAAGE---RVVRRPSYLDLFRTPRLRH----ISLCCV--VVWFGVNF----SY 361

Query: 172 MGHEVKVPLLE-NFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQL 230
            G  + V  L  N Y       ++ L S L + + VR+ GRR    L    T L + L  
Sbjct: 362 YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR----LTQAGTLLGTALAF 417

Query: 231 GLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGG 290
           G   L+             S    +S   +++G   S A  + +  F +E+ PTV+R  G
Sbjct: 418 GTRLLVS------------SDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTG 465

Query: 291 LGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENIS 350
           +GL       G   AP+  L +     L  + +    L+     LLLPE+R   LPE I 
Sbjct: 466 MGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 525

Query: 351 NGE 353
           + E
Sbjct: 526 DVE 528


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 94/363 (25%), Positives = 149/363 (41%), Gaps = 41/363 (11%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           MF+  R   G  LAG  + +  L +E      R +  +++S     G  L+  +  L RD
Sbjct: 195 MFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRD 254

Query: 61  WQVLQALIICPFL--LMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKN-------RM 111
           W+ L   +  P    ++ L+W   PES RWL+     + A R +LH  + N         
Sbjct: 255 WRWLLLAVTLPCAPGILSLWW--VPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSF 312

Query: 112 NPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSM 171
           + E   K    E    + RRP  + + +    R+    I + CV  +  +G++     S 
Sbjct: 313 SQEAVSKVAAGE---RVVRRPSYLDLFRTPRLRH----ISLCCV--VVWFGVNF----SY 359

Query: 172 MGHEVKVPLLE-NFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQL 230
            G  + V  L  N Y       ++ L S L + + VR+ GRR    L    T L + L  
Sbjct: 360 YGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRR----LTQAGTLLGTALAF 415

Query: 231 GLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGG 290
           G   L+             S    +S   +++G   S A  + +  F +E+ PTV+R  G
Sbjct: 416 GTRLLVS------------SDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTG 463

Query: 291 LGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENIS 350
           +GL       G   AP+  L +     L  + +    L+     LLLPE+R   LPE I 
Sbjct: 464 MGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQ 523

Query: 351 NGE 353
           + E
Sbjct: 524 DVE 526


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 84/359 (23%), Positives = 154/359 (42%), Gaps = 38/359 (10%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           +F   RF +G    G  +T Y +  E+    +R ++ +V       G  ++PG+A    +
Sbjct: 207 VFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPN 266

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 120
           WQ +Q  I  P  L LLY+ + PES RWL+  ++ + A +++    + N      +    
Sbjct: 267 WQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNY-SE 325

Query: 121 IPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPL 180
           I   ++E+S        + +V T  + K  ++L     T   ++        G  +++ +
Sbjct: 326 ITVTDEEVS----NPSFLDLVRTPQMRKCTLILMFAWFTSAVVY-------QGLVMRLGI 374

Query: 181 L-ENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKY 239
           +  N Y D++ +  + L   L + + +  LGRR        L   AS +  G+  L+  +
Sbjct: 375 IGGNLYIDFFISGVVELPGALLILLTIERLGRR--------LPFAASNIVAGVACLVTAF 426

Query: 240 SQHPDSGMSDSV----KDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVL 295
                + +  +V    +   ++AF IV +  S            E+ PT +R  G+ L  
Sbjct: 427 LPEGIAWLRTTVATLGRLGITMAFEIVYLVNS------------ELYPTTLRNFGVSLCS 474

Query: 296 ASAGFGMLTAPIIELHNQKGYF-LHHIIFACCTLICIICILLLPESRDQNLPENISNGE 353
               FG + AP +       +  L  IIF     IC   ++LLPE++   LPE + + E
Sbjct: 475 GLCDFGGIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVE 533


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 90/381 (23%), Positives = 161/381 (42%), Gaps = 56/381 (14%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++  LRF     +AG+  +   L  E   P  R    ++A      GQ ++ GLA   R+
Sbjct: 190 LYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRN 249

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNR--MNPEGDIK 118
           W++LQ     P LL+  Y+   PES RWL+   + + A +LI      NR  ++PE  + 
Sbjct: 250 WRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPE-LMN 308

Query: 119 GVIPEL------EKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMM 172
            ++PE         +L R P+   +  ++          V  V+SL  YG+      S+ 
Sbjct: 309 QLVPEKTGPSGNALDLFRHPQLRKVTLII--------FCVWFVDSLGYYGL------SLQ 354

Query: 173 GHEVKVPLLENFYADYYTTASI-----ALVSCLAMCVVVRFLGRRGGLLLFMILTALASL 227
                   + +F  D Y T  I         C ++ ++ RF GR+   L  ++L  L  +
Sbjct: 355 --------VGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRF-GRKWSQLGTLVLGGLMCI 405

Query: 228 LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIR 287
           + + +                 +         ++VG  A+ A  ++S  + AE+ PT++R
Sbjct: 406 IIIFI----------------PADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILR 449

Query: 288 CGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347
             G+GLV   +  G +  P++ L  +    L  +I+    ++  +   LLPE+  Q L +
Sbjct: 450 QTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKD 509

Query: 348 NISN---GEHYTRQPLLPHKK 365
            + +   G H      +P +K
Sbjct: 510 TLQDLELGPHPRSPKSVPSEK 530


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 87/362 (24%), Positives = 148/362 (40%), Gaps = 50/362 (13%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITM--VASFVAMAGQFLMPGLAALC 58
           MF+ L    G       +  + L  E+     R + +   V +F A+ G  L+P  A   
Sbjct: 195 MFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAV-GYMLLPLFAYFI 253

Query: 59  RDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIK 118
           RDW++L   +  P +L +  W   PES RWL++ ++F  A+ +I    + N +     I 
Sbjct: 254 RDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIF 313

Query: 119 GVIPELEKELSRRPKKVCIVKVVGTRNL-WKNIVVLCVNSLTGYGIHHCFARSMMGHEVK 177
             + EL      + +K  I+ +  TRN+    I+ L +  LT  G    FA S+      
Sbjct: 314 DSVEELN---PLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGY---FALSLDAPN-- 365

Query: 178 VPLLENFYADYYTTASIALVSCLAMCVVVRFLGRR----------GGLLLFMILTALASL 227
             L  + Y + + +A I + + +   +++R L RR          GG+LLF+ L  +   
Sbjct: 366 --LHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYY 423

Query: 228 LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIR 287
                                       SI   ++G F   +  S+   F AE+ PT++R
Sbjct: 424 F--------------------------LSIGLVMLGKFGITSAFSMLYVFTAELYPTLVR 457

Query: 288 CGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPE 347
              +G+   ++  G + AP           L +I+    T++  I  L  PES    LPE
Sbjct: 458 NMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPE 517

Query: 348 NI 349
            +
Sbjct: 518 TL 519


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 83/361 (22%), Positives = 135/361 (37%), Gaps = 33/361 (9%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++  LRF  GF    I+   + L +E   P  R M  MV       GQ L+ GLA   +D
Sbjct: 198 VYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQD 257

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAK---RLILHFTQKNRMNPEGDI 117
           W +LQ  +  P +++ L      ES RWL+   Q +      R + H   K         
Sbjct: 258 WHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTT 317

Query: 118 KGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVK 177
           + V   ++KEL     K  I  +     L   +  LC            F R      + 
Sbjct: 318 ELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLC------------FVR----FAIT 361

Query: 178 VPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLF----MILTALASLLQLGLL 233
           VP         +  ++++L   L  C  V F  R   LL        ++ +     +GL 
Sbjct: 362 VPFYGLILNLQHLGSNVSLFQIL--CGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLF 419

Query: 234 NLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGL 293
            L+  +                 +  + +G+ +  A  + +     E+ PT++R    G+
Sbjct: 420 ILVNTFLPQE--------MQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGI 471

Query: 294 VLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGE 353
              S   G   AP++         L  I +    ++ +  ILLLPE+RD  LP  I + E
Sbjct: 472 NAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE 531

Query: 354 H 354
           +
Sbjct: 532 N 532


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 79/361 (21%), Positives = 152/361 (42%), Gaps = 39/361 (10%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   RF   F +AG+++    L +E      R ++  + S     G  L   +A   RD
Sbjct: 198 VYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRD 257

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGV 120
           W +LQ ++  PF L  LY     ES RWL+ T + +   + +        +N +G ++  
Sbjct: 258 WTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAA---INGKGAVQDT 314

Query: 121 I-PEL-------EKELSRRPKKV-CIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSM 171
           + PE+       E  + + P  +  ++++ G R         C+++L  +     F  + 
Sbjct: 315 LTPEVLLSAMREELSMGQPPASLGTLLRMPGLR------FRTCISTLCWFA----FGFTF 364

Query: 172 MGHEVKVPLL-ENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQL 230
            G  + +  L  N +        + + + +   +++  LGRR         T  ASLL  
Sbjct: 365 FGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRP--------TLAASLLLA 416

Query: 231 GLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGG 290
           GL  L      H    +          A +++G+    A  +    + +E+ PTV+R   
Sbjct: 417 GLCILANTLVPHEMGALRS--------ALAVLGLGGVGAAFTCITIYSSELFPTVLRMTA 468

Query: 291 LGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENIS 350
           +GL   +A  G +  P++ L    G +L  +++    ++  +  LLLPE++   LP+ I 
Sbjct: 469 VGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQ 528

Query: 351 N 351
           +
Sbjct: 529 D 529


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 80/354 (22%), Positives = 139/354 (39%), Gaps = 26/354 (7%)

Query: 6   RFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQ 65
           R  +G    G  +  Y L  E    G R  + ++       G   + GLA     W+ LQ
Sbjct: 206 RLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQ 265

Query: 66  ALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELE 125
             +  P  L LLY+   PES RWL++ ++   A +++ H  QKN   P  D+K  +  LE
Sbjct: 266 LAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLK--MLSLE 323

Query: 126 KELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFY 185
           ++++ +        +  T  L K   +L     T   ++      M           N Y
Sbjct: 324 EDVTEK-LSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS------GNLY 376

Query: 186 ADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDS 245
            D+  +A + +       + +  +GR   + +  +L   A L+ + +          PD 
Sbjct: 377 LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFI---------SPDL 427

Query: 246 GMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTA 305
                     +I    VG         +     AE+ PT +R  G+ +  +    G +  
Sbjct: 428 HW-------LNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIIT 480

Query: 306 PIIELHNQKGY-FLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQ 358
           P I    ++ +  L  I+FA   L+     LLLPE++   LPE + + E+  R+
Sbjct: 481 PFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRK 534


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 80/351 (22%), Positives = 150/351 (42%), Gaps = 26/351 (7%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMA-GQFLMPGLAALCR 59
           MF  L    G       +  + L  E+     R + + +   +  A G  ++P  A   R
Sbjct: 195 MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIR 254

Query: 60  DWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKG 119
           DW++L   +  P +L +  W   PES RWL++  +FE A+ +I    + N +     I  
Sbjct: 255 DWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFD 314

Query: 120 VIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVP 179
              EL+   S++ +   I+ ++ T N+    ++  +  +T        +    G  +  P
Sbjct: 315 P-SELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMT-------ISVGYFGLSLDTP 366

Query: 180 LLE-NFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGK 238
            L  + + + + +A + + + +   +++++L RR          ++A+ L LG   L+  
Sbjct: 367 NLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRR---------YSMATALFLGGSVLLFM 417

Query: 239 YSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASA 298
               PD     +V         +VG F   A  S+   + AE+ PTV+R  G+G+   ++
Sbjct: 418 QLVPPDLYYLATV-------LVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTAS 470

Query: 299 GFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENI 349
             G + +P          FL +I+    T++  I  L LPES    LP+ I
Sbjct: 471 RLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 521


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 85/387 (21%), Positives = 155/387 (40%), Gaps = 56/387 (14%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIE--------------LCPPGKRFMITMVASFVAMA 46
           ++ +LRF  G     +I     L  E              +CP G  FM           
Sbjct: 198 IYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMT---------- 247

Query: 47  GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFT 106
               + GLA   RDW +LQ ++  P+ ++ L  S   ES RWL+   + E   + +    
Sbjct: 248 ----LAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAA 303

Query: 107 QKNRMNPEGD---IKGVIPELEKEL-SRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYG 162
            ++ M    D   ++ +   ++KEL + + KK  + +++   N+ K I +L       + 
Sbjct: 304 HRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFM 363

Query: 163 IHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILT 222
            +      +      V LL+  +      A I L +C+A   + +++ RR   +L M L 
Sbjct: 364 AYFGLNLHVQHLGNNVFLLQTLFG-----AVILLANCVAPWAL-KYMNRRASQMLLMFLL 417

Query: 223 ALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEIT 282
           A+  L  + +   +    +                  + +G+ AS    +L+     E+ 
Sbjct: 418 AICLLAIIFVPQEMQTLRE----------------VLATLGLGASALANTLAFAHGNEVI 461

Query: 283 PTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRD 342
           PT+IR   +G+    A      AP++ + +     L  II+     I     LLLPE+R+
Sbjct: 462 PTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRN 521

Query: 343 QNLPENISNGEHYTRQPLLPHKKGEQP 369
           + L + I + ++  + P  P  K E P
Sbjct: 522 KPLFDTIQDEKNERKDPREP--KQEDP 546


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 87/368 (23%), Positives = 155/368 (42%), Gaps = 49/368 (13%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++  LRF   F +AGI L+   L +E     +R +   V      AGQ  + GLA   RD
Sbjct: 195 IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRD 254

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLM-------ATQQFESAKRLILHFTQKNRMNP 113
           W+ LQ     PF  + L     PES RWL+       A Q+     R+  H   KN    
Sbjct: 255 WRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNL--- 311

Query: 114 EGDIKGVIPELEKEL--SRRPKKVCIVKVVGTRNLWKNIVVLCVN---SLTGYGIHHCFA 168
              I+ ++  +++E+  ++ P+ V  +  V     W++  +L VN    ++ YG+   F 
Sbjct: 312 --TIEVLMSSVKEEVASAKEPRSVLDLFCVPVLR-WRSCAMLVVNFSLLISYYGL--VFD 366

Query: 169 RSMMGHEVKVPLLENFY--ADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALAS 226
              +G ++   LL+  +   D+   A+ AL        ++ FLGRR        +  LA 
Sbjct: 367 LQSLGRDIF--LLQALFGAVDFLGRATTAL--------LLSFLGRRTIQAGSQAMAGLAI 416

Query: 227 LLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVI 286
           L  +    L+ +  Q               + F+++G        +    + AE+ PT +
Sbjct: 417 LANM----LVPQDLQ------------TLRVVFAVLGKGCFGISLTCLTIYKAELFPTPV 460

Query: 287 RCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLI-CIICILLLPESRDQNL 345
           R    G++      G +  P+I +  Q    L  +++   ++   ++ +  LPE++   L
Sbjct: 461 RMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPL 520

Query: 346 PENISNGE 353
           P+ I + E
Sbjct: 521 PDTIQDLE 528


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 91/320 (28%), Positives = 146/320 (45%), Gaps = 43/320 (13%)

Query: 47  GQFLMPGLAALCRDWQVL---QALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLIL 103
           G  L+ G+A     WQ+L     +++ PF+  +  W I PES RWLM   + + AK+++ 
Sbjct: 282 GAVLLTGIAYSLPHWQLLFLVGGILVIPFISYI--W-ILPESPRWLMMKGKVKEAKQVLC 338

Query: 104 HFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVG---TRNLWK-NIVVLCVNSLT 159
           +    N+       K +   L  EL    KKV    V+     R L K  +V+ CV    
Sbjct: 339 YAASVNK-------KTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTV 391

Query: 160 GYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCV-VVRFLGRRGGLLLF 218
            Y     F  S+   E+ V +        +   SI  V     C+ +++ +GR+  L + 
Sbjct: 392 SYTY---FTLSLRMRELGVSVHFR-----HVVPSIMEVPARLCCIFLLQQIGRKWSLAVT 443

Query: 219 MILTALASLLQL----GLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLS 274
           ++   +  LL L    G   L  K+ + P + +        +I   ++  F+  A  ++ 
Sbjct: 444 LLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKS-----MTILVLMLREFSLAATVTVF 498

Query: 275 VFFCAEITPTVIRCGGLGLV-LASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIIC 333
             + AE+ PTV+R  GLGLV LAS    +L+  II   +Q    L   IF CC L  +  
Sbjct: 499 FLYTAELLPTVLRATGLGLVSLASVAGAILSLTII---SQTPSLLP--IFLCCVLAIVAF 553

Query: 334 IL--LLPESRDQNLPENISN 351
            L  LLPE+RDQ L E++++
Sbjct: 554 SLSSLLPETRDQPLSESLNH 573


>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 78/348 (22%), Positives = 141/348 (40%), Gaps = 38/348 (10%)

Query: 31  GKRFMITMVASFVAMA---GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLR 87
           G+R+  T V  F  +A   G  ++ G+A     W+ LQ  +  P    LLY+   PES R
Sbjct: 230 GRRYRRT-VGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPR 288

Query: 88  WLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLW 147
           WL++  +   A R+I H  +KN  +    ++ +   LE+E  ++      + +V T  + 
Sbjct: 289 WLISQNKNAEAMRIIKHIAKKNGKSLPASLQRL--RLEEETGKKLNP-SFLDLVRTPQIR 345

Query: 148 KNIVVLCVNSLTGYGIHHCFARSM--MGHEVKVPLLENFYADYYTTASIALVSCLAMCVV 205
           K+ ++L  N  T   ++      M   G        +N Y D++ +A +   +   + + 
Sbjct: 346 KHTMILMYNWFTSSVLYQGLIMHMGLAG--------DNIYLDFFYSALVEFPAAFMIILT 397

Query: 206 VRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMF 265
           +  +GRR       ++   A L  + +   +                    I  S +G  
Sbjct: 398 IDRIGRRYPWAASNMVAGAACLASVFIPGDL----------------QWLKIIISCLGRM 441

Query: 266 ASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYF-LHHIIFA 324
                  +     AE+ PT IR  G+ +  +    G +  P +       +  L  ++F 
Sbjct: 442 GITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFG 501

Query: 325 CCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLL 372
              L+    +LLLPE++ + LPE I   E+  R    P K  E+ + L
Sbjct: 502 VLGLVAGGLVLLLPETKGKALPETIEEAENMQR----PRKNKEKMIYL 545


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 56/234 (23%), Positives = 103/234 (44%), Gaps = 15/234 (6%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   R   G  LAGI L    L +E  P   R  +  +  +V   GQFL+ G+A     
Sbjct: 187 IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH 246

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEG---DI 117
           W+ LQ L+  PF    +Y   F ES RW  ++ + +   R +    + N    EG    +
Sbjct: 247 WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSM 306

Query: 118 KGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL---TGYGIHHCFARSMMGH 174
           + +   L+KEL+    +   ++++    L    + LC++ L   T +  ++     + G 
Sbjct: 307 EVLRASLQKELTMGKGQASAMELLRCPTL--RHLFLCLSMLWFATSFA-YYGLVMDLQGF 363

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLL 228
            V + L++  +       ++ L + L   +V+  LGRR   +  ++L  +  LL
Sbjct: 364 GVSIYLIQVIF------GAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 56/234 (23%), Positives = 103/234 (44%), Gaps = 15/234 (6%)

Query: 1   MFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRD 60
           ++   R   G  LAGI L    L +E  P   R  +  +  +V   GQFL+ G+A     
Sbjct: 187 IYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPH 246

Query: 61  WQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEG---DI 117
           W+ LQ L+  PF    +Y   F ES RW  ++ + +   R +    + N    EG    +
Sbjct: 247 WRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSM 306

Query: 118 KGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSL---TGYGIHHCFARSMMGH 174
           + +   L+KEL+    +   ++++    L    + LC++ L   T +  ++     + G 
Sbjct: 307 EVLRASLQKELTMGKGQASAMELLRCPTL--RHLFLCLSMLWFATSFA-YYGLVMDLQGF 363

Query: 175 EVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLL 228
            V + L++  +       ++ L + L   +V+  LGRR   +  ++L  +  LL
Sbjct: 364 GVSIYLIQVIF------GAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILL 411


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 70/315 (22%), Positives = 133/315 (42%), Gaps = 39/315 (12%)

Query: 47  GQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFT 106
           G  L   +A   RDW +LQ ++  PF L  LY     ES RWL+ T + +   + +    
Sbjct: 23  GHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVA 82

Query: 107 QKNRMNPEGDIKGVI-PEL-------EKELSRRPKKV-CIVKVVGTRNLWKNIVVLCVNS 157
               +N +G ++  + PE+       E  + + P  +  ++++ G R         C+++
Sbjct: 83  A---INGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLR------FRTCIST 133

Query: 158 LTGYGIHHCFARSMMGHEVKVPLL-ENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLL 216
           L  +     F  +  G  + +  L  N +        + + + +   +++  LGRR    
Sbjct: 134 LCWFA----FGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRP--- 186

Query: 217 LFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVF 276
                T  ASLL  GL  L      H    +          A +++G+    A  +    
Sbjct: 187 -----TLAASLLLAGLCILANTLVPHEMGALRS--------ALAVLGLGGVGAAFTCITI 233

Query: 277 FCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILL 336
           + +E+ PTV+R   +GL   +A  G +  P++ L    G +L  +++    ++  +  LL
Sbjct: 234 YSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALL 293

Query: 337 LPESRDQNLPENISN 351
           LPE++   LP+ I +
Sbjct: 294 LPETQSLPLPDTIQD 308


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 51/225 (22%), Positives = 90/225 (40%), Gaps = 9/225 (4%)

Query: 6   RFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQ 65
           R  +G    G  +  Y L  E    G R  + ++       G   + GLA     W+ LQ
Sbjct: 206 RLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQ 265

Query: 66  ALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELE 125
             +  P  L LLY+   PES RWL++ ++   A +++ H  QKN   P  D+K  +  LE
Sbjct: 266 LAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLK--MLSLE 323

Query: 126 KELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFY 185
           ++++ +        +  T  L K   +L     T   ++      M           N Y
Sbjct: 324 EDVTEK-LSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATS------GNLY 376

Query: 186 ADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQL 230
            D+  +A + +       + +  +GR   + +  +L   A L+ +
Sbjct: 377 LDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMI 421


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 88/379 (23%), Positives = 151/379 (39%), Gaps = 40/379 (10%)

Query: 2   FSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDW 61
           F+  RF  G    G+ L  + L  E        +   +       G      L    R W
Sbjct: 165 FAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSW 224

Query: 62  QVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVI 121
           + L  L+     ++ L     PES RWL +  +   A+  +    ++NR      +K   
Sbjct: 225 RTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK-----LKCTF 279

Query: 122 PELEKELSRRPKKV-CIVKVVGTRNLWKNIVVLC----VNSLTGYGIHHCFARSMMGHEV 176
             L    +R  ++    + +   R L  + ++L     V SL  YG+    +   +G  +
Sbjct: 280 -SLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGL--TLSAGDLGGSI 336

Query: 177 KVPLLENFYADYYTTASIALVSCLAMCVVV---RFLGRRGGLLLFMILTALASLLQLGLL 233
                   YA+   +  I + S   +C+ +   ++ GR+  L  F+ L  LA L+ + L 
Sbjct: 337 --------YANLALSGLIEIPS-YPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFL- 386

Query: 234 NLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGL 293
                  +  D+G+   V    S + S++G     A  ++   + +E+ PTVIR  GLG 
Sbjct: 387 ------PEKKDTGVFAVVN---SHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGT 437

Query: 294 VLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGE 353
               +  G + AP I       + L  I+F    L   +  LLLPE+ +  L E  S+ +
Sbjct: 438 CSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQ 497

Query: 354 HYTRQPLLPHKKGEQPLLL 372
            Y+ + L     GE+ L L
Sbjct: 498 VYSYRRL-----GEEALSL 511


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.142    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,945,368
Number of Sequences: 37866
Number of extensions: 627476
Number of successful extensions: 1837
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 37
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1726
Number of HSP's gapped (non-prelim): 71
length of query: 405
length of database: 18,247,518
effective HSP length: 105
effective length of query: 300
effective length of database: 14,271,588
effective search space: 4281476400
effective search space used: 4281476400
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.