BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|48375167 microtubule-associated protein 6 isoform 2 [Homo sapiens] (439 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|48375167 microtubule-associated protein 6 isoform 2 [Homo sap... 896 0.0 gi|48375173 microtubule-associated protein 6 isoform 1 [Homo sap... 896 0.0 gi|13376306 MAP6 domain containing 1 [Homo sapiens] 77 4e-14 gi|169207312 PREDICTED: hypothetical protein [Homo sapiens] 60 4e-09 gi|239750650 PREDICTED: hypothetical protein [Homo sapiens] 60 4e-09 gi|89037350 PREDICTED: hypothetical protein [Homo sapiens] 60 4e-09 gi|110832843 TBP-associated factor 4 [Homo sapiens] 54 2e-07 gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 52 1e-06 gi|112421108 capicua homolog [Homo sapiens] 52 1e-06 gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 51 2e-06 gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 50 3e-06 gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 50 3e-06 gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 50 3e-06 gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 50 3e-06 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 50 4e-06 gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 50 5e-06 gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 49 9e-06 gi|116256464 hypothetical protein LOC343990 [Homo sapiens] 49 1e-05 gi|30089916 phosphofurin acidic cluster sorting protein 1 [Homo ... 47 3e-05 gi|4506321 protein tyrosine phosphatase, receptor type, N precur... 46 8e-05 gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H... 46 8e-05 gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 45 1e-04 gi|153791535 general control of amino acid synthesis 5-like 2 [H... 45 1e-04 gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 45 1e-04 gi|73476377 LBXCOR1 homolog [Homo sapiens] 45 1e-04 gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 45 2e-04 gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] 45 2e-04 gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 45 2e-04 gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 45 2e-04 gi|153792074 proline rich 12 [Homo sapiens] 45 2e-04 >gi|48375167 microtubule-associated protein 6 isoform 2 [Homo sapiens] Length = 439 Score = 896 bits (2316), Expect = 0.0 Identities = 439/439 (100%), Positives = 439/439 (100%) Query: 1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP Sbjct: 1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60 Query: 61 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV Sbjct: 61 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120 Query: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI Sbjct: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180 Query: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR Sbjct: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240 Query: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS Sbjct: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300 Query: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI Sbjct: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360 Query: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK Sbjct: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420 Query: 421 PDDKEQSKEMNNKLAEAKE 439 PDDKEQSKEMNNKLAEAKE Sbjct: 421 PDDKEQSKEMNNKLAEAKE 439 >gi|48375173 microtubule-associated protein 6 isoform 1 [Homo sapiens] Length = 813 Score = 896 bits (2316), Expect = 0.0 Identities = 439/439 (100%), Positives = 439/439 (100%) Query: 1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP Sbjct: 1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60 Query: 61 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV Sbjct: 61 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120 Query: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI Sbjct: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180 Query: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR Sbjct: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240 Query: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS Sbjct: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300 Query: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI Sbjct: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360 Query: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK Sbjct: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420 Query: 421 PDDKEQSKEMNNKLAEAKE 439 PDDKEQSKEMNNKLAEAKE Sbjct: 421 PDDKEQSKEMNNKLAEAKE 439 >gi|13376306 MAP6 domain containing 1 [Homo sapiens] Length = 199 Score = 76.6 bits (187), Expect = 4e-14 Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 20/156 (12%) Query: 1 MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEA-TEHPG----APPQPPPPQQQAQP 55 MAWPCI+R CC+AR WNQLD++D+AVPL YS+ +E PG A + PP Sbjct: 1 MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDLDSEEPGTGGAASRRGQPPAGARDS 60 Query: 56 ALAPPSA---RAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPG----- 107 P R + T PA G D G PG G R ++ + P PG Sbjct: 61 GRDVPLTQYQRDFGLWTTPA-GPKDP---PPGRGPGAGGRRGKSSAQSSAPPAPGARGVY 116 Query: 108 ---LGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140 +G + + RQ+++AW +P S + + Sbjct: 117 VLPIGDADAAAAVTTSYRQEFQAWTGVKPSRSTKTK 152 Score = 40.8 bits (94), Expect = 0.002 Identities = 16/30 (53%), Positives = 23/30 (76%) Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKP 321 + A+AV++SYR EF+AWT +KP + K KP Sbjct: 124 DAAAAVTTSYRQEFQAWTGVKPSRSTKTKP 153 >gi|169207312 PREDICTED: hypothetical protein [Homo sapiens] Length = 414 Score = 60.1 bits (144), Expect = 4e-09 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%) Query: 16 WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73 W +L P + + PG PQP Q +P + PP V + P + Sbjct: 74 WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133 Query: 74 GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117 L A ARA G P+P E PA+ SG PGP G GS Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191 Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171 + + + R PE P CR S P + +K R PLPR Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251 Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227 P S++ A P +P R P + P A E R +P A GG ++ Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308 Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277 G SG D + A PA A G P + + A GP + R Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358 >gi|239750650 PREDICTED: hypothetical protein [Homo sapiens] Length = 414 Score = 60.1 bits (144), Expect = 4e-09 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%) Query: 16 WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73 W +L P + + PG PQP Q +P + PP V + P + Sbjct: 74 WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133 Query: 74 GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117 L A ARA G P+P E PA+ SG PGP G GS Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191 Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171 + + + R PE P CR S P + +K R PLPR Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251 Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227 P S++ A P +P R P + P A E R +P A GG ++ Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308 Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277 G SG D + A PA A G P + + A GP + R Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358 >gi|89037350 PREDICTED: hypothetical protein [Homo sapiens] Length = 414 Score = 60.1 bits (144), Expect = 4e-09 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%) Query: 16 WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73 W +L P + + PG PQP Q +P + PP V + P + Sbjct: 74 WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133 Query: 74 GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117 L A ARA G P+P E PA+ SG PGP G GS Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191 Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171 + + + R PE P CR S P + +K R PLPR Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251 Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227 P S++ A P +P R P + P A E R +P A GG ++ Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308 Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277 G SG D + A PA A G P + + A GP + R Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358 >gi|110832843 TBP-associated factor 4 [Homo sapiens] Length = 1085 Score = 54.3 bits (129), Expect = 2e-07 Identities = 73/262 (27%), Positives = 86/262 (32%), Gaps = 42/262 (16%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA--- 96 P P P PP + +P PP A + PA A A A GP P P G +PA Sbjct: 113 PLVPAGPAPPAAKLRP---PPEGSAGSCAPVPA-----AAAVAAGPEPAPAGPAKPAGPA 164 Query: 97 -----AGPGRS---GPGPGLGSGSTSGPADSVMRQDYRAW----KVQRPEPSC--RPRSE 142 AGPG GPGPG G G +GP + A P S + Sbjct: 165 ALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAA 224 Query: 143 YQPSDAPFERETQYQKD----FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRP 198 P P T Q A P P P P P +AA P R P Sbjct: 225 LLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPP 284 Query: 199 QSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQ 258 P A A A GG+ G A A A GPA + + Sbjct: 285 GHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAA--------GGPAGVSGQPGPGAAAA 336 Query: 259 TPLPAAQAQ-----VQATGPEA 275 P P +A+ VQA P A Sbjct: 337 APAPGVKAESPKRVVQAAPPAA 358 Score = 36.6 bits (83), Expect = 0.046 Identities = 61/233 (26%), Positives = 79/233 (33%), Gaps = 26/233 (11%) Query: 38 EHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPG-PTGEREPA 96 E P Q PP Q A P S A + QG L + A PAPG PTG + A Sbjct: 345 ESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGA 404 Query: 97 AGP-----GRSGPGPGLGSGSTSGPADSVMR------QDYRAWKVQRPEPSCRPRSEY-Q 144 AG R+ G +T P R Q P RSE Q Sbjct: 405 AGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464 Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIP---KPVQISAASQASAPILGAPKR----- 196 P + Q Q A P P P PVQIS PI+ Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTII 524 Query: 197 RPQSQERWPVQAAAEAR-----EQEAAPGGAGGLAAGKASGADERDTRRKAGP 244 + SQ + VQ +A + + + GGA A+ + A + T ++ P Sbjct: 525 KQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVP 577 Score = 35.4 bits (80), Expect = 0.10 Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 13/89 (14%) Query: 36 ATEHPGAPPQPPPPQQQAQPALA--------PPSARAVAIETQPAQGELDAVARATGPAP 87 A P AP PPP A LA PP+A A A+ A + A PAP Sbjct: 259 AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTA-APAVPPPAAAQNGGSAGAAPAPAP 317 Query: 88 ---GPTG-EREPAAGPGRSGPGPGLGSGS 112 GP G +P G + P PG+ + S Sbjct: 318 AAGGPAGVSGQPGPGAAAAAPAPGVKAES 346 >gi|4826998 splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) [Homo sapiens] Length = 707 Score = 51.6 bits (122), Expect = 1e-06 Identities = 57/209 (27%), Positives = 72/209 (34%), Gaps = 22/209 (10%) Query: 43 PPQPPPPQQQA--QPALAPPSARAVAIETQPAQGELDAVARATGPAPG-----PTGEREP 95 PPQ PPPQQ QP P + P VA+ GPAPG P P Sbjct: 73 PPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAP 132 Query: 96 AAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQ 155 A P SG PG G G T P +V A P S P + Q P Sbjct: 133 PATPPTSGAPPGSGPGPTPTPPPAVTSAPPGA-PPPTPPSSGVPTTPPQAGGPPPPPAAV 191 Query: 156 YQKDFRAWPLPRRGDHPWIPKPVQISAASQ-ASAPILGAPKRRPQSQERWPVQAAA---- 210 P P++G P PK ++ + P L P P+ R + Sbjct: 192 PGPG----PGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQH 247 Query: 211 -----EAREQEAAPGGAGGLAAGKASGAD 234 + Q PGG GG + K S ++ Sbjct: 248 HPPYHQQHHQGPPPGGPGGRSEEKISDSE 276 Score = 48.9 bits (115), Expect = 9e-06 Identities = 32/82 (39%), Positives = 35/82 (42%), Gaps = 6/82 (7%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQ--GELDAVARATGPAPGP---TGERE 94 PG P PPP A P PP+ + + T P Q G A GP PGP G Sbjct: 147 PGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGG 206 Query: 95 PAAGPGRSGPGPGLGSG-STSG 115 P G GP PG G G ST G Sbjct: 207 PKGGKMPGGPKPGGGPGLSTPG 228 >gi|112421108 capicua homolog [Homo sapiens] Length = 1608 Score = 51.6 bits (122), Expect = 1e-06 Identities = 98/411 (23%), Positives = 139/411 (33%), Gaps = 76/411 (18%) Query: 27 PLVFTKYSEATEHPGAP---------PQPPPPQQQAQPALAPPS-ARAVAIETQPAQGEL 76 P+ + A PG P P P AQP+ APPS VA T P Sbjct: 1074 PVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPA--- 1130 Query: 77 DAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPS 136 A GP P P A P + P P +GS M A K QRP P Sbjct: 1131 -ATILPKGP-PAPA-----TATPAPTSPFPSATAGS--------MTYSLVAPKAQRPSPK 1175 Query: 137 CRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKR 196 + + + P + R P PR+ P P PV+ A ++ P Sbjct: 1176 APQKVKAAIASIPV-GSFEAGASGRPGPAPRQ---PLEPGPVREPTAPESELEGQPTPPA 1231 Query: 197 RPQSQERWPVQAAAE------AREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIV-- 248 P E W A + A E+ +A G + +S +D W V Sbjct: 1232 PPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSD-----------WRVPG 1280 Query: 249 RRAEGLGHEQTPLPAAQAQVQATG--PEAGRGRAAADALNRQIREEVASAVSSSYRNEFR 306 + E G TP A A A G E+ GRAA D R+ V Sbjct: 1281 QGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVK-------- 1332 Query: 307 AWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSE 366 V+P K + D++++ E + +F A P +V+ ++SL + Sbjct: 1333 -------VRPPPLKKTFDSVDNRVLSEVDFEERF---AELPEFRPEEVLPSPTLQSLATS 1382 Query: 367 P---FKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAE 414 P K K S + S P RK + + + S + KSA+ Sbjct: 1383 PRAILGSYRKKRKNSTDLDSAPEDPTS--PKRKMRRRSSCSSEPNTPKSAK 1431 Score = 38.1 bits (87), Expect = 0.016 Identities = 48/161 (29%), Positives = 65/161 (40%), Gaps = 37/161 (22%) Query: 42 APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGR 101 AP QP P Q ++ P++ VA E AVA PG TG +P PG Sbjct: 45 APSQPDPSVQPSEAQ--QPASHPVASNQSKEPAESAAVAHER--PPGGTGSADPERPPGA 100 Query: 102 S-----GPGP---------GLGSGST-----SGP-----ADSVMRQDY-------RAWKV 130 + GPGP G G T SGP DS D+ + ++ Sbjct: 101 TCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEI 160 Query: 131 QRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171 Q P P + R++ S P ER++ +KD R+ P R DH Sbjct: 161 QLPLPPGKRRTQ-SLSALPKERDSSSEKDGRS-PNKREKDH 199 Score = 30.8 bits (68), Expect = 2.5 Identities = 29/84 (34%), Positives = 36/84 (42%), Gaps = 7/84 (8%) Query: 21 KADIAVPLVFTKYSEATEHPG-APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV 79 KA IA V + + A+ PG AP QP P +P P + T PA L Sbjct: 1181 KAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTA--PESELEGQPTPPAPPPLPET 1238 Query: 80 ----ARATGPAPGPTGEREPAAGP 99 AR++ P P P ER A GP Sbjct: 1239 WTPTARSSPPLPPPAEERTSAKGP 1262 Score = 30.4 bits (67), Expect = 3.3 Identities = 26/79 (32%), Positives = 31/79 (39%), Gaps = 6/79 (7%) Query: 40 PGAP---PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA 96 PGA P PPP A PA P A T P+ A A P P +G +P Sbjct: 1529 PGAEAPLPVPPPTGTAAAPAPTPSPAGGPD-PTSPSSDSGTAQAAPPLPPPPESGPGQPG 1587 Query: 97 --AGPGRSGPGPGLGSGST 113 P S P PG + +T Sbjct: 1588 WEGAPQPSPPPPGPSTAAT 1606 Score = 28.9 bits (63), Expect = 9.7 Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 9/96 (9%) Query: 43 PPQPP-PPQQQAQPALAPPSARAVAIETQPAQGELDAVAR---ATGPAPGPTGEREPAAG 98 PP PP PP + + PS+ A + PA A +G + AG Sbjct: 514 PPGPPDPPVAFGKGYGSAPSSSA----SSPASSSASAATSFSLGSGTFKAQESGQGSTAG 569 Query: 99 PGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPE 134 P R P PG G +T A + D ++ +RPE Sbjct: 570 PLRPPP-PGAGGPATPSKATRFLPMDPATFRRKRPE 604 Score = 28.9 bits (63), Expect = 9.7 Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 11/66 (16%) Query: 51 QQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGS 110 Q A P PP A A + P G A PAP P+ PA GP + P G+ Sbjct: 1520 QAATPTEQPPGAEA-PLPVPPPTGT------AAAPAPTPS----PAGGPDPTSPSSDSGT 1568 Query: 111 GSTSGP 116 + P Sbjct: 1569 AQAAPP 1574 >gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] Length = 1682 Score = 51.2 bits (121), Expect = 2e-06 Identities = 98/406 (24%), Positives = 137/406 (33%), Gaps = 90/406 (22%) Query: 31 TKYSEATEHPGAPPQPP----PPQQQAQPALAPP-------SARAVAIETQPAQGELDAV 79 T+ E P PP PP PP Q QP PP + A +E Q Sbjct: 764 TQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGA 823 Query: 80 ARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRP 139 A +T P P PT + P G + P + S G P+PS Sbjct: 824 AVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQG----------------SPQPSASS 867 Query: 140 RSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQ 199 S++ S P+ RE R G+ P +P P+ P L P R + Sbjct: 868 SSQFSTSGGPWARER------------RAGEEP-VPGPM----TPTQPPPPLSLPPARSE 910 Query: 200 SQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT 259 S+ + A E + S D D A PA G E+ Sbjct: 911 SEVLEEISRACETLVERVG-----------RSATDPADPVDTAEPA-------DSGTERL 952 Query: 260 PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPI-- 317 LP AQA+ EAG A + + R+ +E +R RA D +P Sbjct: 953 -LPPAQAK-----EEAGGVAAVSGSCKRRQKEH-----QKEHRRHRRACKDSVGRRPREG 1001 Query: 318 KAKPQYKPPDDK----MVHETSYSAQFKG-EASKPTTADNKVIDRRRIRSLYSEPFKEPP 372 +AK + K P +K + + S + +G E S+P D PP Sbjct: 1002 RAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRP--------DLGGASKAKPPTAPAPP 1053 Query: 373 KVEKPSVQSSKPKKTSASHKPTRKAKDKQAVS-GQAAKKKS-AEGP 416 PS Q + P + K +A VS K +S +EGP Sbjct: 1054 SAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGP 1099 Score = 32.0 bits (71), Expect = 1.1 Identities = 65/300 (21%), Positives = 104/300 (34%), Gaps = 31/300 (10%) Query: 43 PPQP-PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA-AGPG 100 PP+P PPP + L PP++R ++ TQ + T + +G + AGP Sbjct: 511 PPRPAPPPLPHREGFLGPPASR-FSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPV 569 Query: 101 RSGPGPGLGSG---STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQ 157 P P L P+ + QD + P P S +Q + F R + Sbjct: 570 SFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPR 629 Query: 158 KDFRAWPLPRRGDHPWIPKPVQISAASQASAPILG-APKRRPQSQERWPV---QAAAEAR 213 P G P P +S A Q P +G P R P+ + P E Sbjct: 630 PRVSFPKTPEVGPG---PPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPA 686 Query: 214 EQEAAPGGAGGL--AAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQAT 271 E + P G + ++ +E + +AG A Q PL A +Q+ Sbjct: 687 EFKILPDGLANIMKMLDESIRKEEEQQQHEAGVA-----------PQPPLKEPFASLQSP 735 Query: 272 GPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPI-----KAKPQYKPP 326 P A A+ + +++ E + + P P+ ++PQ PP Sbjct: 736 FPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPP 795 >gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e [Homo sapiens] Length = 1451 Score = 50.4 bits (119), Expect = 3e-06 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%) Query: 22 ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81 A + V TK S A + AP + Q + PP+ RA E + E + + Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280 Query: 82 ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133 PA + + A+ P + PG G + + G A +V Q K +P Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335 Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191 E SE + SD+ E ET K L + K Q+ AAS + +P Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384 Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250 GA P +A A RE+++ ++ ++ +E + K +G A VR Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310 A E AA A + TGP AA + +Q + +S+ S E A + Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493 Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369 VKP+ PQ KP + A P T +V SE Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553 Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425 + E P+ + +K+ + KPT AK +G A + AE KP D Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608 Query: 426 QSKEMNNKLAEAKE 439 +S E ++ A+++E Sbjct: 609 ESSEESSDSADSEE 622 Score = 41.6 bits (96), Expect = 0.001 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%) Query: 52 QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111 + +P++ P +A ++ T+ ++ AR PAPG G+ P G P Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261 Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171 RA K + S SE + +AP +Q + Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294 Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231 K +Q+ AAS AP G P + A PG AG +A+ + Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332 Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291 G E D+ + E+TP A Q +A+G + G A+A A +E Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380 Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351 + P P K P E S S+ + ++ + A Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426 Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411 K P + P+V S + + + A+ P RK A +++ Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473 Query: 412 SAEGPSTTKPDDKEQSKEMN 431 + S D+E MN Sbjct: 474 DSRSSSEESDSDREALAAMN 493 Score = 38.1 bits (87), Expect = 0.016 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%) Query: 41 GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94 GA P PP A P+ S + + + GE+ AVA A + G + + Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153 P + P + P +GP A +V+ +P S + SD A E Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623 Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213 +A P + PK +A+++ AP R R A + A Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677 Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269 A GG A +S + K G A V +A+ +G + +P + Q Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737 Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328 T P G+ + + +E+ S+ S E A P + K K Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790 Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377 K + + KG S P KV+ ++ P K P V P Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845 Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437 SV S +A+ T +D + ++ ++ AE + KP K + ++ LA A Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903 Query: 438 KE 439 KE Sbjct: 904 KE 905 Score = 38.1 bits (87), Expect = 0.016 Identities = 57/255 (22%), Positives = 90/255 (35%), Gaps = 52/255 (20%) Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT-------------- 259 +QEA P A G+ + K G ++ P + +G G+ Q Sbjct: 1207 KQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLL 1263 Query: 260 --PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPV--- 314 P P +AQVQA+ L + +E V ++ + + W K Sbjct: 1264 GQPWPLNEAQVQAS---------VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1314 Query: 315 -KPIKAKPQYKPPD--------DKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYS 365 +P P+ K + V S KG+A K A V +++ SL S Sbjct: 1315 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA-KRDKASGDVKEKKGKGSLGS 1373 Query: 366 EPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPST 418 + K+ P+ E S PK K ++ KDK+ + KKK A+ ST Sbjct: 1374 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKE----KKEKKKKAKKAST 1429 Query: 419 TKPDDKEQSKEMNNK 433 + Q K+ K Sbjct: 1430 KDSESPSQKKKKKKK 1444 Score = 34.7 bits (78), Expect = 0.18 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G P + + + A A+ A G+ V A+ PA + A PG Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 ++GP +A +R E S +S + SD+ E Q + Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220 +A V+ ++A +P GA P ++ P A + +QE Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472 Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276 S ++E D+ R+A A + + LG PA+ + G AG Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526 Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315 ++D+ + ++ VA A S N +A P K Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586 Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367 P KA P KP D+ E S + EA TA + +I + P Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645 Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423 K KV V + P+K + P A AV+G ++ AE S+++ D Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700 Query: 424 KEQSK 428 E+ K Sbjct: 701 SEEEK 705 >gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d [Homo sapiens] Length = 1488 Score = 50.4 bits (119), Expect = 3e-06 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%) Query: 22 ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81 A + V TK S A + AP + Q + PP+ RA E + E + + Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280 Query: 82 ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133 PA + + A+ P + PG G + + G A +V Q K +P Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335 Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191 E SE + SD+ E ET K L + K Q+ AAS + +P Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384 Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250 GA P +A A RE+++ ++ ++ +E + K +G A VR Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310 A E AA A + TGP AA + +Q + +S+ S E A + Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493 Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369 VKP+ PQ KP + A P T +V SE Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553 Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425 + E P+ + +K+ + KPT AK +G A + AE KP D Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608 Query: 426 QSKEMNNKLAEAKE 439 +S E ++ A+++E Sbjct: 609 ESSEESSDSADSEE 622 Score = 41.6 bits (96), Expect = 0.001 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%) Query: 52 QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111 + +P++ P +A ++ T+ ++ AR PAPG G+ P G P Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261 Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171 RA K + S SE + +AP +Q + Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294 Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231 K +Q+ AAS AP G P + A PG AG +A+ + Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332 Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291 G E D+ + E+TP A Q +A+G + G A+A A +E Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380 Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351 + P P K P E S S+ + ++ + A Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426 Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411 K P + P+V S + + + A+ P RK A +++ Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473 Query: 412 SAEGPSTTKPDDKEQSKEMN 431 + S D+E MN Sbjct: 474 DSRSSSEESDSDREALAAMN 493 Score = 38.9 bits (89), Expect = 0.009 Identities = 102/457 (22%), Positives = 154/457 (33%), Gaps = 99/457 (21%) Query: 25 AVPLVFTKYSEATEHPGAPPQPPPPQQQAQ---PALAPPSARAVAIET----QPAQGELD 77 A+ ++ K SEA + P A QP A PA +P S A T +P E+ Sbjct: 1076 ALKVLAQKASEA-QPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQ 1134 Query: 78 AVARATGPAPGPTGEREPAAGPGRSGPGP-GLGSGSTSGPADSVMRQDYRAWKVQRPEPS 136 +A + + ++G G GP G S T GP S Sbjct: 1135 QATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS----------------- 1177 Query: 137 CRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKR 196 R+E + E + D A P + P A SQAS K Sbjct: 1178 ---RTETLVEETAAESS---EDDVVA---PSQSLLSGYMTPGLTPANSQAS-------KA 1221 Query: 197 RPQSQERWPVQAAAEARE-----QEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRA 251 P+ V + A++ QEA P A G+ + K G ++ P + Sbjct: 1222 TPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPK 1278 Query: 252 EGLGHEQT----------------PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVAS 295 +G G+ Q P P +AQVQA+ L + +E Sbjct: 1279 KGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQAS---------VVKVLTELLEQERKK 1329 Query: 296 AVSSSYRNEFRAWTDIKPV----KPIKAKPQYKPPD--------DKMVHETSYSAQFKGE 343 V ++ + + W K +P P+ K + V S KG+ Sbjct: 1330 VVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGK 1389 Query: 344 ASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRK 396 A K A V +++ SL S+ K+ P+ E S PK K ++ Sbjct: 1390 A-KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1448 Query: 397 AKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNK 433 KDK+ + KKK A+ ST + Q K+ K Sbjct: 1449 KKDKE----KKEKKKKAKKASTKDSESPSQKKKKKKK 1481 Score = 38.1 bits (87), Expect = 0.016 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%) Query: 41 GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94 GA P PP A P+ S + + + GE+ AVA A + G + + Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153 P + P + P +GP A +V+ +P S + SD A E Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623 Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213 +A P + PK +A+++ AP R R A + A Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677 Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269 A GG A +S + K G A V +A+ +G + +P + Q Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737 Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328 T P G+ + + +E+ S+ S E A P + K K Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790 Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377 K + + KG S P KV+ ++ P K P V P Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845 Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437 SV S +A+ T +D + ++ ++ AE + KP K + ++ LA A Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903 Query: 438 KE 439 KE Sbjct: 904 KE 905 Score = 34.7 bits (78), Expect = 0.18 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G P + + + A A+ A G+ V A+ PA + A PG Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 ++GP +A +R E S +S + SD+ E Q + Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220 +A V+ ++A +P GA P ++ P A + +QE Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472 Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276 S ++E D+ R+A A + + LG PA+ + G AG Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526 Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315 ++D+ + ++ VA A S N +A P K Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586 Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367 P KA P KP D+ E S + EA TA + +I + P Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645 Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423 K KV V + P+K + P A AV+G ++ AE S+++ D Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700 Query: 424 KEQSK 428 E+ K Sbjct: 701 SEEEK 705 >gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo sapiens] Length = 1450 Score = 50.4 bits (119), Expect = 3e-06 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%) Query: 22 ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81 A + V TK S A + AP + Q + PP+ RA E + E + + Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280 Query: 82 ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133 PA + + A+ P + PG G + + G A +V Q K +P Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335 Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191 E SE + SD+ E ET K L + K Q+ AAS + +P Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384 Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250 GA P +A A RE+++ ++ ++ +E + K +G A VR Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310 A E AA A + TGP AA + +Q + +S+ S E A + Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493 Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369 VKP+ PQ KP + A P T +V SE Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553 Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425 + E P+ + +K+ + KPT AK +G A + AE KP D Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608 Query: 426 QSKEMNNKLAEAKE 439 +S E ++ A+++E Sbjct: 609 ESSEESSDSADSEE 622 Score = 41.6 bits (96), Expect = 0.001 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%) Query: 52 QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111 + +P++ P +A ++ T+ ++ AR PAPG G+ P G P Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261 Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171 RA K + S SE + +AP +Q + Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294 Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231 K +Q+ AAS AP G P + A PG AG +A+ + Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332 Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291 G E D+ + E+TP A Q +A+G + G A+A A +E Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380 Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351 + P P K P E S S+ + ++ + A Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426 Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411 K P + P+V S + + + A+ P RK A +++ Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473 Query: 412 SAEGPSTTKPDDKEQSKEMN 431 + S D+E MN Sbjct: 474 DSRSSSEESDSDREALAAMN 493 Score = 38.1 bits (87), Expect = 0.016 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%) Query: 41 GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94 GA P PP A P+ S + + + GE+ AVA A + G + + Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153 P + P + P +GP A +V+ +P S + SD A E Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623 Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213 +A P + PK +A+++ AP R R A + A Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677 Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269 A GG A +S + K G A V +A+ +G + +P + Q Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737 Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328 T P G+ + + +E+ S+ S E A P + K K Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790 Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377 K + + KG S P KV+ ++ P K P V P Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845 Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437 SV S +A+ T +D + ++ ++ AE + KP K + ++ LA A Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903 Query: 438 KE 439 KE Sbjct: 904 KE 905 Score = 38.1 bits (87), Expect = 0.016 Identities = 57/255 (22%), Positives = 90/255 (35%), Gaps = 52/255 (20%) Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT-------------- 259 +QEA P A G+ + K G ++ P + +G G+ Q Sbjct: 1206 KQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLL 1262 Query: 260 --PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPV--- 314 P P +AQVQA+ L + +E V ++ + + W K Sbjct: 1263 GQPWPLNEAQVQAS---------VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1313 Query: 315 -KPIKAKPQYKPPD--------DKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYS 365 +P P+ K + V S KG+A K A V +++ SL S Sbjct: 1314 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA-KRDKASGDVKEKKGKGSLGS 1372 Query: 366 EPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPST 418 + K+ P+ E S PK K ++ KDK+ + KKK A+ ST Sbjct: 1373 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKE----KKEKKKKAKKAST 1428 Query: 419 TKPDDKEQSKEMNNK 433 + Q K+ K Sbjct: 1429 KDSESPSQKKKKKKK 1443 Score = 34.7 bits (78), Expect = 0.18 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G P + + + A A+ A G+ V A+ PA + A PG Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 ++GP +A +R E S +S + SD+ E Q + Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220 +A V+ ++A +P GA P ++ P A + +QE Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472 Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276 S ++E D+ R+A A + + LG PA+ + G AG Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526 Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315 ++D+ + ++ VA A S N +A P K Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586 Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367 P KA P KP D+ E S + EA TA + +I + P Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645 Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423 K KV V + P+K + P A AV+G ++ AE S+++ D Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700 Query: 424 KEQSK 428 E+ K Sbjct: 701 SEEEK 705 >gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo sapiens] Length = 958 Score = 50.4 bits (119), Expect = 3e-06 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%) Query: 22 ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81 A + V TK S A + AP + Q + PP+ RA E + E + + Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280 Query: 82 ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133 PA + + A+ P + PG G + + G A +V Q K +P Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335 Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191 E SE + SD+ E ET K L + K Q+ AAS + +P Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384 Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250 GA P +A A RE+++ ++ ++ +E + K +G A VR Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438 Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310 A E AA A + TGP AA + +Q + +S+ S E A + Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493 Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369 VKP+ PQ KP + A P T +V SE Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553 Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425 + E P+ + +K+ + KPT AK +G A + AE KP D Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608 Query: 426 QSKEMNNKLAEAKE 439 +S E ++ A+++E Sbjct: 609 ESSEESSDSADSEE 622 Score = 41.6 bits (96), Expect = 0.001 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%) Query: 52 QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111 + +P++ P +A ++ T+ ++ AR PAPG G+ P G P Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261 Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171 RA K + S SE + +AP +Q + Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294 Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231 K +Q+ AAS AP G P + A PG AG +A+ + Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332 Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291 G E D+ + E+TP A Q +A+G + G A+A A +E Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380 Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351 + P P K P E S S+ + ++ + A Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426 Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411 K P + P+V S + + + A+ P RK A +++ Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473 Query: 412 SAEGPSTTKPDDKEQSKEMN 431 + S D+E MN Sbjct: 474 DSRSSSEESDSDREALAAMN 493 Score = 38.1 bits (87), Expect = 0.016 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%) Query: 41 GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94 GA P PP A P+ S + + + GE+ AVA A + G + + Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153 P + P + P +GP A +V+ +P S + SD A E Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623 Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213 +A P + PK +A+++ AP R R A + A Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677 Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269 A GG A +S + K G A V +A+ +G + +P + Q Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737 Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328 T P G+ + + +E+ S+ S E A P + K K Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790 Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377 K + + KG S P KV+ ++ P K P V P Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845 Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437 SV S +A+ T +D + ++ ++ AE + KP K + ++ LA A Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903 Query: 438 KE 439 KE Sbjct: 904 KE 905 Score = 34.7 bits (78), Expect = 0.18 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G P + + + A A+ A G+ V A+ PA + A PG Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 ++GP +A +R E S +S + SD+ E Q + Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220 +A V+ ++A +P GA P ++ P A + +QE Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472 Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276 S ++E D+ R+A A + + LG PA+ + G AG Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526 Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315 ++D+ + ++ VA A S N +A P K Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586 Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367 P KA P KP D+ E S + EA TA + +I + P Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645 Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423 K KV V + P+K + P A AV+G ++ AE S+++ D Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700 Query: 424 KEQSK 428 E+ K Sbjct: 701 SEEEK 705 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 50.1 bits (118), Expect = 4e-06 Identities = 100/457 (21%), Positives = 169/457 (36%), Gaps = 64/457 (14%) Query: 34 SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93 S A E +PP+ P+++ A +P ++ PA+ E + A A P + + Sbjct: 552 SPAKEEAKSPPEAKSPEKEE--AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609 Query: 94 EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD----AP 149 E A P + + S + + + + PE + P E S +P Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669 Query: 150 FERETQYQKDFRAWPLPRRGDHPWIPK-PVQISAASQASAPILGAPKRRPQSQERWPVQA 208 + E + + ++ P+ P K PV+ A S A + + + + PV+ Sbjct: 670 VKAEAKSPEKAKS-PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728 Query: 209 AAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPA----- 263 A+ E+ +P + KA ++ T P A+ E+ PA Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP-----EAKTPAKEEARSPADKFPE 783 Query: 264 ---AQAQVQATGPEAGRGRAAADAL--NRQI--REEVASAVSSSYRNEFRAWTDIKPVKP 316 + + + PE + DA ++I +EEV S V + + ++K +P Sbjct: 784 KAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ-----EVKVKEP 838 Query: 317 IKAKPQYKPPDDKMVHETSYSAQF---KGEASKPTTADNKVIDRRRIRSLYSEPFKEP-- 371 K + K P E S + K EA KP + K + + E KE Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898 Query: 372 -------PKVEKPSV----QSSKPK-KTSASHK---------PTRKAKDKQAV-----SG 405 P+ E P+ + +KPK KT + K P++ A+ K+A + Sbjct: 899 DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958 Query: 406 QAAKKKSAEGPST---TKPDDKEQSKEMNNKLAEAKE 439 + KK E P T K DDK SKE + AE E Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995 Score = 47.8 bits (112), Expect = 2e-05 Identities = 59/268 (22%), Positives = 109/268 (40%), Gaps = 25/268 (9%) Query: 177 PVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADER 236 PV+ A S A A + + ++ + P +A + A+E+ +P A + E+ Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA---------KSPEK 569 Query: 237 DTRRKAGPAWIVRRAEGLGHEQTPLPA-AQAQVQATGPEAGRGRAAADALNRQIREEVAS 295 + + +A+ E+ PA A++ +A P ++ A+A ++EE S Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA-KSPVKEEAKS 628 Query: 296 AVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKV- 354 + ++ T + P KAK P ++ + K EA P A + V Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAK---SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685 Query: 355 ---IDRRRIRSLYSEPFKEPPKVEKPSVQSSK-PKKTSASHKPTRKAKDKQAVSGQAAKK 410 + +S E K P K + P + +K P+K + K K +K ++ K Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK----AKSPVK 741 Query: 411 KSAEGPSTTKPDDKEQSKEMNNKLAEAK 438 + A+ P K E++K ++ K EAK Sbjct: 742 EEAKSPEKAK--SPEKAKTLDVKSPEAK 767 Score = 33.9 bits (76), Expect = 0.30 Identities = 83/418 (19%), Positives = 152/418 (36%), Gaps = 78/418 (18%) Query: 47 PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE------------RE 94 P ++ P A +A A + A+ + A A++ A P E +E Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRA-WKVQRPEPSCRPRSEYQPSDAPFERE 153 A P ++ P T A S ++++ ++ K + PE + + + P + E Sbjct: 715 EAKSPEKA-KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773 Query: 154 TQYQKDFRAWPLPRRGDHPW-----IPKPVQISAASQASAPILGAPKRR----PQSQERW 204 + D P + P P+ + A AP PK+ P +E Sbjct: 774 ARSPAD----KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829 Query: 205 P----VQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260 P V+ + E+E AP A K +++D++++ P ++ P Sbjct: 830 PQEVKVKEPPKKAEEEKAP------ATPKTE--EKKDSKKEEAPK-----------KEAP 870 Query: 261 LPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAK 320 P + + + + + A + +++V + + + D KP + K + Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA-KVEVKEDAKPKE--KTE 927 Query: 321 PQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQ 380 K PDD E S A+ K A P D K ++ +E PK E + + Sbjct: 928 VAKKEPDDAKAKEPSKPAEKKEAA--PEKKDTKEEKAKKP--------EEKPKTEAKAKE 977 Query: 381 SSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAK 438 K + S +P++ +K A+K S ST + D K K +K A+ K Sbjct: 978 DDK----TLSKEPSKPKAEK-------AEKSS----STDQKDSKPPEKATEDKAAKGK 1020 >gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo sapiens] Length = 1130 Score = 49.7 bits (117), Expect = 5e-06 Identities = 32/120 (26%), Positives = 46/120 (38%), Gaps = 3/120 (2%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G PP PPPP A P P+ A PA+ E + + A GP P P P GP Sbjct: 794 GLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPV 853 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 P + G+ G + +D + S E + + E E + ++DF Sbjct: 854 TLPPPQLVPEGTPGGGGPPALEEDLTVINI---NSSDEEEEEEEEEEEEEEEEEEEEEDF 910 Score = 34.7 bits (78), Expect = 0.18 Identities = 24/79 (30%), Positives = 33/79 (41%), Gaps = 19/79 (24%) Query: 40 PGAPPQPPPPQQQAQPALAP-----------------PSARAVAIETQPAQGEL--DAVA 80 P PP PP+ Q +P P +A +A E P+QGE+ + + Sbjct: 984 PALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGES 1043 Query: 81 RATGPAPGPTGEREPAAGP 99 A GP P E EP+A P Sbjct: 1044 PAAGPPPQELVEEEPSAPP 1062 Score = 32.7 bits (73), Expect = 0.67 Identities = 23/74 (31%), Positives = 27/74 (36%), Gaps = 3/74 (4%) Query: 36 ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQP--AQGELDAVARATGPAPGPTGER 93 A HP PP P PA PP P G + +V P P+ Sbjct: 629 ALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGP 688 Query: 94 EPAAGPGRSG-PGP 106 P+AGP S PGP Sbjct: 689 MPSAGPVPSARPGP 702 >gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 preproprotein [Homo sapiens] Length = 331 Score = 48.9 bits (115), Expect = 9e-06 Identities = 62/257 (24%), Positives = 85/257 (33%), Gaps = 31/257 (12%) Query: 34 SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAPG 88 S + P PQ PPPQ QP PP + P QG + GP P Sbjct: 87 SRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNRPQGPPPPGKPQGPPPQ 144 Query: 89 PTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQ 144 R P + PG+ P G GP + K Q P P +P+ Sbjct: 145 GDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQG--P 202 Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQS 200 P R +Q P P+ G+ P P P Q + P P +PQ Sbjct: 203 PPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 262 Query: 201 QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260 P Q ++++ + P GK G +++ GP A G + Sbjct: 263 P---PAQGGSKSQSARSPP--------GKPQGPPQQEGNNPQGPP---PPAGGNPQQPQA 308 Query: 261 LPAAQAQVQATGPEAGR 277 PA Q Q P+ GR Sbjct: 309 PPAGQPQGPPRPPQGGR 325 Score = 37.7 bits (86), Expect = 0.021 Identities = 43/188 (22%), Positives = 63/188 (33%), Gaps = 22/188 (11%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99 P PQ PPPQ +P PP + + P QG+ ++ P P + P Sbjct: 53 PPGKPQGPPPQGGNKPQGPPPPGKP---QGPPPQGD-----KSRSPRSPPGKPQGPPPQG 104 Query: 100 GRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKD 159 G GP G GP + Q P P +P+ P R + Sbjct: 105 GNQPQGPPPPPGKPQGPPPQ------GGNRPQGPPPPGKPQG--PPPQGDKSRSPRSPPG 156 Query: 160 FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRR---PQSQERWPVQAAAEAREQE 216 P P+ G+ P P P P G K + P + + P ++R + Sbjct: 157 KPQGPPPQGGNQPQGPPP---PPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQ 213 Query: 217 AAPGGAGG 224 + PG G Sbjct: 214 SPPGKPQG 221 Score = 33.5 bits (75), Expect = 0.39 Identities = 36/128 (28%), Positives = 46/128 (35%), Gaps = 18/128 (14%) Query: 34 SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93 S +++ P PQ PPPQ QP PP + P QG + GP P + Sbjct: 209 SRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGG----NKPQGPPPPGKPQG 262 Query: 94 EPAAG-----PGRSGPGPGLGSGSTSG-------PADSVMRQDYRAWKVQRPEPSCRPRS 141 PA G RS PG G G P Q +A +P+ RP Sbjct: 263 PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQ 322 Query: 142 EYQPSDAP 149 +PS P Sbjct: 323 GGRPSRPP 330 >gi|116256464 hypothetical protein LOC343990 [Homo sapiens] Length = 962 Score = 48.5 bits (114), Expect = 1e-05 Identities = 102/442 (23%), Positives = 156/442 (35%), Gaps = 102/442 (23%) Query: 43 PPQPPPPQQQAQPALAPPSARAVAIETQPAQGEL-DAVARATGPAPGPTGEREPAAGPGR 101 PP+ P P+ R+V E +P L D GPAP P E E G Sbjct: 413 PPETDPAATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREAETEPERGA 472 Query: 102 SGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEP-SCRPRSEYQPSDAPFERETQYQKDF 160 +G+ ++ PA S P P SC S+ P Sbjct: 473 GTEPERIGTEPSTAPAPS------------PPAPKSCLKHRPAAASEGPAASP------- 513 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQ--ERWPVQAAAEAREQEAA 218 PL P P P + A +A+AP RP+++ E P A A E++A Sbjct: 514 ---PLAAAESPPVEPGPGSLDA--EAAAP------ERPKAERAEAPPAGAERAAPERKAE 562 Query: 219 PGGAGGLAAGKASGADERDTRR-----------------KAGPAWIVRRA----EGLGHE 257 GGA A K S + R R ++GP W A +GL Sbjct: 563 RGGAELRGAKKFSVSSCRARPRPGVSRPLERASGRLPLARSGPVWRSEAALDDLQGLPEP 622 Query: 258 QTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASA-------------VSSSYRNE 304 Q P + ++ GP+ RAA+ A R+ +E A+A S RN Sbjct: 623 QHAKPGPR-KLAERGPQDSGDRAASPAGPRKSPQEAAAAPGTREPCPAAQEPAPSEDRNP 681 Query: 305 F---------------RAWTDIKPVKPIKAKPQYK------PPDDKMVHET--------S 335 F A ++K VK A+ + + P ++K T + Sbjct: 682 FPVKLRSTSLSLKYRDGASQEVKGVKRYSAEVRLERSLTVLPKEEKCPLGTAPALRGTRA 741 Query: 336 YSAQFKGEASKPTTADNK-VIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPT 394 S Q KG+A P +K + R+ + ++ P + P P + + + +A +P Sbjct: 742 PSDQGKGKARPPEPLSSKPPLPRKPLLQSFTLPHQPAPPDAGPGEREPRKEPRTAEKRPL 801 Query: 395 RKAKDKQ---AVSGQAAKKKSA 413 R+ +K A +G A + A Sbjct: 802 RRGAEKSLPPAATGPGADGQPA 823 >gi|30089916 phosphofurin acidic cluster sorting protein 1 [Homo sapiens] Length = 963 Score = 47.0 bits (110), Expect = 3e-05 Identities = 32/99 (32%), Positives = 36/99 (36%), Gaps = 7/99 (7%) Query: 42 APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGR 101 +P QPPP QQQ QP P + Q A A + T A Sbjct: 28 SPQQPPPQQQQQQPPQQPTPPKL----AQATSSSSSTSAAAASSSSSSTSTSMAVAVASG 83 Query: 102 SGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140 S P G G G T P V Y W+V R SC PR Sbjct: 84 SAPPGGPGPGRTPAP---VQMNLYATWEVDRSSSSCVPR 119 >gi|4506321 protein tyrosine phosphatase, receptor type, N precursor [Homo sapiens] Length = 979 Score = 45.8 bits (107), Expect = 8e-05 Identities = 76/276 (27%), Positives = 104/276 (37%), Gaps = 45/276 (16%) Query: 38 EHPGAPPQPPPPQQQAQPALAPP--------SARAVAIETQPAQGELDAVARATGPAPGP 89 EH PPQPP P +PAL P + E P + + +A PA Sbjct: 186 EHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPA--- 242 Query: 90 TGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQP 145 A G G PG G GP+ + + QD Y A ++ P + PR Q Sbjct: 243 --LFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG 300 Query: 146 SDAPFERETQ-YQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERW 204 S + E + Y+K+ L RG+ P P VQ AA Q A +L + ++ Sbjct: 301 SSSRAEDSPEGYEKE----GLGDRGEKPASP-AVQPDAALQRLAAVLAG--YGVELRQLT 353 Query: 205 PVQAAAEAREQEAAPGGAGGLAAGKAS-GADERDTRRKAGPAWIVRRAEGLGHEQTPLPA 263 P Q + + P GAG G + GAD + T GP G + LPA Sbjct: 354 PEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTME--GPV--------EGRDTAELPA 403 Query: 264 AQAQVQATGPEAGRGRAAADALNRQIREEVASAVSS 299 T P G A+ + Q +V S VSS Sbjct: 404 ------RTSPMPGHPTASPTSSEVQ---QVPSPVSS 430 >gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo sapiens] Length = 309 Score = 45.8 bits (107), Expect = 8e-05 Identities = 48/163 (29%), Positives = 54/163 (33%), Gaps = 35/163 (21%) Query: 39 HPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAG 98 HPG P PPP Q + PP R E P QG ++ GP P P P + Sbjct: 179 HPGKPEGPPP--QGGNQSQGPPP-RPGKPEGPPPQGG----NQSQGPPPRPGKPEGPPSQ 231 Query: 99 PGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQK 158 G GP G GP K QRP P RP+ P P + Sbjct: 232 GGNKPQGPPPHPGKPQGPPPQ------EGNKPQRPPPPGRPQGPPPPGGNPQQ------- 278 Query: 159 DFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQ 201 PLP P P P P G P R PQ Q Sbjct: 279 -----PLPPPAGKPQGPPP----------PPQGGRPHRPPQGQ 306 Score = 39.7 bits (91), Expect = 0.005 Identities = 69/256 (26%), Positives = 83/256 (32%), Gaps = 44/256 (17%) Query: 41 GAPPQP-----PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREP 95 G PP+P PPPQ Q PP R E QP QG ++ GP P P P Sbjct: 70 GPPPRPGKPEGPPPQGGNQSQGPPP--RPGKPEGQPPQGG----NQSQGPPPRPGKPEGP 123 Query: 96 AAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQ 155 G GP G GP Q Q P P RP +P P + Q Sbjct: 124 PPQGGNQSQGPPPRPGKPEGPPPQGGNQS------QGPPP--RPG---KPEGPPPQGGNQ 172 Query: 156 YQKDFRAWPLPRRGDHPWIPK--PVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213 Q P P HP P+ P Q SQ P G P+ P Sbjct: 173 SQ-----GPPP----HPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPG 223 Query: 214 EQEAAPGGAGGLA------AGKASGADERDTRRKAGPAWIVRRAEGL----GHEQTPLPA 263 + E P G GK G ++ + P R +G G+ Q PLP Sbjct: 224 KPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPP-PPGRPQGPPPPGGNPQQPLPP 282 Query: 264 AQAQVQATGPEAGRGR 279 + Q P GR Sbjct: 283 PAGKPQGPPPPPQGGR 298 >gi|237757326 synaptojanin 1 isoform d [Homo sapiens] Length = 1526 Score = 45.4 bits (106), Expect = 1e-04 Identities = 59/236 (25%), Positives = 82/236 (34%), Gaps = 29/236 (12%) Query: 43 PPQPPPPQQQAQPA--LAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 P P P + AQP PP R VA T+PA + P P+G +P+ G Sbjct: 1085 PATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQ---------RPPPPSGRSQPSPQAG 1135 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRS-EYQPSDAPFERETQYQKD 159 +GPGP ST+ P RA + P+ R + P ET Sbjct: 1136 LAGPGP--AGYSTARPTIPP-----RAGVISAPQSHARASAGRLTPESQSKTSETSKGST 1188 Query: 160 FRAWPL-PRRGDHPWIPKPVQISAASQASAPILG-APKRRPQSQERWPVQAAAEAREQEA 217 F PL P+ P P + P+ P+ PQ P Q +R + Sbjct: 1189 FLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHS 1248 Query: 218 APGGAGGLAAGKASGADE--RDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQAT 271 P A K +G + R++ K P E L + AQ VQ + Sbjct: 1249 LPSEASSQPQVKTNGISDGKRESPLKIDP------FEDLSFNLLAVSKAQLSVQTS 1298 Score = 31.6 bits (70), Expect = 1.5 Identities = 38/167 (22%), Positives = 61/167 (36%), Gaps = 30/167 (17%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99 P P +PPPP ++QP+ P G GP P P P Sbjct: 1115 PAPPQRPPPPSGRSQPS--------------PQAG-------LAGPGPAGYSTARPTI-P 1152 Query: 100 GRSG--PGPGLGSGSTSG---PADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA--PFER 152 R+G P + +++G P + PEP +P++ + P + P + Sbjct: 1153 PRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEP-LKPQAAFPPQSSLPPPAQ 1211 Query: 153 ETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQ 199 Q A P+P+ G P + P Q S++S + +PQ Sbjct: 1212 RLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1258 >gi|153791535 general control of amino acid synthesis 5-like 2 [Homo sapiens] Length = 837 Score = 45.4 bits (106), Expect = 1e-04 Identities = 32/86 (37%), Positives = 35/86 (40%), Gaps = 3/86 (3%) Query: 43 PPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRS 102 P Q P P AQP P + A A PA A PAP P PA G Sbjct: 4 PSQAPTPAPAAQPR--PLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGTG 61 Query: 103 GPGPGL-GSGSTSGPADSVMRQDYRA 127 GPG G G+GS PA + Q RA Sbjct: 62 GPGVGSGGAGSGGDPARPGLSQQQRA 87 Score = 33.9 bits (76), Expect = 0.30 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 5/99 (5%) Query: 37 TEHPGAPPQP---PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93 T P A P+P P P PA +P SA PA A A +TG G G Sbjct: 9 TPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT--GGPGVG 66 Query: 94 EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQR 132 AG G PGL + + +R RA K+++ Sbjct: 67 SGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEK 105 >gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] Length = 2303 Score = 45.4 bits (106), Expect = 1e-04 Identities = 78/313 (24%), Positives = 118/313 (37%), Gaps = 46/313 (14%) Query: 31 TKYSEATEHPGAPPQPPPPQQQ--AQPALAPPSARAVAIETQPAQGELDAVARATGPAPG 88 T+ + A PGA P P P + A+ S + +PA+ +ARA P PG Sbjct: 1894 TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAV-PEPG 1952 Query: 89 PTGEREPAAGPGRSGPGPG-------LGSGSTSGPADSVMRQ-----DYRAWKVQRPEPS 136 P G AGPG G G L SGS S RQ + + +R E S Sbjct: 1953 PRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELS 2012 Query: 137 CRPRSEYQPSDAP--------------FERETQYQKDFRAWPLPRRGDHPWI-----PKP 177 + P A R + + R P P R P +P Sbjct: 2013 SAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERP 2072 Query: 178 VQISAASQASAPILGAPKRRPQSQERW---PVQAAAEAREQEAAPGGAGGLAAGKASGAD 234 + + + S + AP RP++ +R+ P + A + A AA ++S + Sbjct: 2073 ARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGE 2132 Query: 235 ERDTRRKAGP--AWIVRRAEGLGH-EQTPLPAAQAQVQATGPEAGRG----RAAADALNR 287 R R A P W R E + H ++ LPA ++ + PE R +DA+ + Sbjct: 2133 PRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQ 2192 Query: 288 QIREEVASAVSSS 300 EEVA+ ++S Sbjct: 2193 --TEEVAAPKTNS 2203 Score = 44.7 bits (104), Expect = 2e-04 Identities = 66/266 (24%), Positives = 94/266 (35%), Gaps = 33/266 (12%) Query: 25 AVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARA----VAIETQPAQGELDAVA 80 A+P FT+ E P + P P + A PA APP AR +A ET P + + Sbjct: 1532 AIPRAFTR-----ERPQGRKEAPAPSKAA-PA-APPPARTQPSLIADETPPCYSLSSSAS 1584 Query: 81 RATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140 + P P P PG G G S P+ + +QR S PR Sbjct: 1585 SLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEE-----LLQRCISSALPR 1639 Query: 141 SEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQS 200 S + + D R P G + AS + A + S Sbjct: 1640 RRPPVSGLRRRKPRATRLDER----PAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695 Query: 201 QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEG-LGHEQT 259 W QAAA RE + +G + G+ + + + G R+AEG +G + Sbjct: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKG-----RQAEGEMGSARR 1750 Query: 260 PLPAAQAQVQAT-------GPEAGRG 278 P A V+ + GPE RG Sbjct: 1751 PEKRGAASVKTSGSPRSPAGPEKPRG 1776 Score = 38.9 bits (89), Expect = 0.009 Identities = 71/323 (21%), Positives = 110/323 (34%), Gaps = 48/323 (14%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G P P++ A P LA P+A A P Q ++ R P T E + P Sbjct: 1807 GTPGPRATPRKVAPPCLAQPAAPAKV--PSPGQQRSRSLHR-----PAKTSELATLSQPP 1859 Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160 RS P + + S + +P P RP P + Sbjct: 1860 RSATPPARLAKTPSSSSSQTS-------PASQPLPRKRP---------PVTQAAGALPGP 1903 Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRR--PQSQERWPVQAAAEAREQEAA 218 A P+P+ + K + + S P + P RR P P EA Sbjct: 1904 GASPVPKTPARTLLAKQHK-TQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAG 1962 Query: 219 PGGAGG------LAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQA-T 271 PG GG +A+ +SG++ D ++ + GL ++ L +A++ A Sbjct: 1963 PGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQ 2022 Query: 272 GPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKP-----P 326 G RGR A A+ + SS E RA P + P +P P Sbjct: 2023 GASPRRGRPALPAV----------FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERP 2072 Query: 327 DDKMVHETSYSAQFKGEASKPTT 349 + E+ + A++P T Sbjct: 2073 ARRTTSESPSRLPVRAPAARPET 2095 Score = 34.3 bits (77), Expect = 0.23 Identities = 28/75 (37%), Positives = 33/75 (44%), Gaps = 13/75 (17%) Query: 25 AVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATG 84 A+P VF S E AP Q P P +Q PP+AR P+ GE A R T Sbjct: 2032 ALPAVFLCSSRCEELRAAPRQGPAPARQ-----RPPAAR-------PSPGERPA-RRTTS 2078 Query: 85 PAPGPTGEREPAAGP 99 +P R PAA P Sbjct: 2079 ESPSRLPVRAPAARP 2093 >gi|73476377 LBXCOR1 homolog [Homo sapiens] Length = 921 Score = 45.1 bits (105), Expect = 1e-04 Identities = 55/206 (26%), Positives = 80/206 (38%), Gaps = 35/206 (16%) Query: 35 EATEHPGAPPQPPPPQQQAQPALAPPSARAVAIET-QPAQGELDAVARATGPAPGPTGER 93 EA P AP PPPP PP+ + + +P + +++A+ G A G Sbjct: 525 EALPPPLAPLPPPPP---------PPARKGSYVSAFRPVVKDTESIAKLYGSAREAYG-- 573 Query: 94 EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP------EPSCRPRSEYQPSD 147 AGP R GPGPG GSG P + + ++ P EP S P D Sbjct: 574 ---AGPAR-GPGPGAGSGGYVSP--DFLSEGSSSYNSASPDVDTADEPEVDVESNRFPDD 627 Query: 148 APFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAA-SQASAPILGAPKRR------PQS 200 + ET+ G+ P P S A A++P G+P+ R P Sbjct: 628 EDAQEETEPSAPSAGG--GPDGEQPTGPPSATSSGADGPANSPDGGSPRPRRRLGPPPAG 685 Query: 201 QERWPVQAAAE--AREQEAAPGGAGG 224 + + AA + R + + P G GG Sbjct: 686 RPAFGDLAAEDLVRRPERSPPSGGGG 711 >gi|62000702 diacylglycerol kinase kappa [Homo sapiens] Length = 1271 Score = 44.7 bits (104), Expect = 2e-04 Identities = 36/122 (29%), Positives = 41/122 (33%), Gaps = 22/122 (18%) Query: 38 EHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER---- 93 E P P+PPPP P APP A + E P A GP P T E Sbjct: 18 EQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATEL 77 Query: 94 ------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD 147 EPA P S P P + PA PEP+ P +E P Sbjct: 78 YTEPTPEPATEPA-SEPAPEPATEPAPEPATE-----------PAPEPAPEPATESAPEP 125 Query: 148 AP 149 P Sbjct: 126 TP 127 Score = 28.9 bits (63), Expect = 9.7 Identities = 32/118 (27%), Positives = 38/118 (32%), Gaps = 17/118 (14%) Query: 33 YSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92 Y+E T P P P + PA P A A E P A A P P P E Sbjct: 78 YTEPTPEPATEPASEPAPE---PATEP--APEPATEPAPEPAPEPATESAPEPTPEPALE 132 Query: 93 REPAAGPGRSGP-GPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAP 149 P P + P L T P + PE E++PS AP Sbjct: 133 SVPEPAPELTPEVAPELAPEPTPEPVTEL-----------APEFCPEAAPEFRPSPAP 179 Score = 28.9 bits (63), Expect = 9.7 Identities = 32/113 (28%), Positives = 41/113 (36%), Gaps = 17/113 (15%) Query: 54 QPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGST 113 +PA P S A T+PA AT PAP P E + P P P S Sbjct: 84 EPATEPASEPAPEPATEPAP------EPATEPAPEPAPEPATESAP---EPTPEPALESV 134 Query: 114 SGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLP 166 PA + + PEP+ P +E P P + +FR P P Sbjct: 135 PEPAPELTPE---VAPELAPEPTPEPVTELAPEFCP-----EAAPEFRPSPAP 179 >gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] Length = 1120 Score = 44.7 bits (104), Expect = 2e-04 Identities = 66/258 (25%), Positives = 96/258 (37%), Gaps = 40/258 (15%) Query: 44 PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSG 103 P PPPP++ + +++ PS ++ P GP G TG R +G Sbjct: 786 PPPPPPKRLS--SVSGPSPEPPPLDESP------------GPKEGATGPRRRTLSE-PAG 830 Query: 104 PGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA-PFERE---TQYQKD 159 P G + +GPA ++ P P P S + PF E T Q+ Sbjct: 831 PSEPPGPPAPAGPASDTEEEE--------PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRP 882 Query: 160 FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEA-REQEAA 218 A P PR P P + S + KRRP+ +ER P+Q A A A Sbjct: 883 KPAGPPPRE-----TPVPPGLDFNLTESDTV----KRRPKCREREPLQTALLAFGVASAT 933 Query: 219 PGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRG 278 PG A L + + + + P+ + A+G+ P PA Q V P G Sbjct: 934 PGPAAPLPSPTPGESPPASSLPQPEPSSL--PAQGVPTPLAPSPAMQPPVPPC-PGPGLE 990 Query: 279 RAAADALNRQIREEVASA 296 +AA N + A A Sbjct: 991 SSAASRWNGETEPPAAPA 1008 Score = 34.3 bits (77), Expect = 0.23 Identities = 61/251 (24%), Positives = 83/251 (33%), Gaps = 48/251 (19%) Query: 36 ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV---------ARATGPA 86 A + G P PP + + PP + P QG V + A GP Sbjct: 634 APQPSGGDPSPPQERNLPEGTERPPKL----CSSLPGQGPPPYVFMYPQGSPSSPAPGPP 689 Query: 87 PGPTGEREPAAGPGRSGPGP-----------------GLGSGSTSGPADSVMRQDYRAWK 129 PG AGP + P P G G GP S + A Sbjct: 690 PGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGS--YATL 747 Query: 130 VQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAP 189 +RP S R+ + P R T + F A R+G P P P ++S+ S S Sbjct: 748 TRRPGRSALVRTSPSVTPTP-ARGTPRSQSF-ALRARRKGPPP--PPPKRLSSVSGPS-- 801 Query: 190 ILGAPKRRPQSQERWPVQAAAEAR----EQEAAPGGAGG--LAAGKASGADERDTRRKAG 243 P+ P + P + A R + A P G AG AS +E + + Sbjct: 802 ----PEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGT 857 Query: 244 PAWIVRRAEGL 254 P EGL Sbjct: 858 PPSRGSSGEGL 868 Score = 32.7 bits (73), Expect = 0.67 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%) Query: 34 SEATEHPGAP-PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92 + AT P AP P P P + +L P ++ PAQG V P+P Sbjct: 930 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSL-----PAQG----VPTPLAPSPAMQPP 980 Query: 93 REPAAGPGRSGPGPGLGSGSTSGPA 117 P GPG +G T PA Sbjct: 981 VPPCPGPGLESSAASRWNGETEPPA 1005 >gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] Length = 1202 Score = 44.7 bits (104), Expect = 2e-04 Identities = 66/258 (25%), Positives = 96/258 (37%), Gaps = 40/258 (15%) Query: 44 PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSG 103 P PPPP++ + +++ PS ++ P GP G TG R +G Sbjct: 868 PPPPPPKRLS--SVSGPSPEPPPLDESP------------GPKEGATGPRRRTLSE-PAG 912 Query: 104 PGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA-PFERE---TQYQKD 159 P G + +GPA ++ P P P S + PF E T Q+ Sbjct: 913 PSEPPGPPAPAGPASDTEEEE--------PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRP 964 Query: 160 FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEA-REQEAA 218 A P PR P P + S + KRRP+ +ER P+Q A A A Sbjct: 965 KPAGPPPRE-----TPVPPGLDFNLTESDTV----KRRPKCREREPLQTALLAFGVASAT 1015 Query: 219 PGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRG 278 PG A L + + + + P+ + A+G+ P PA Q V P G Sbjct: 1016 PGPAAPLPSPTPGESPPASSLPQPEPSSL--PAQGVPTPLAPSPAMQPPVPPC-PGPGLE 1072 Query: 279 RAAADALNRQIREEVASA 296 +AA N + A A Sbjct: 1073 SSAASRWNGETEPPAAPA 1090 Score = 34.3 bits (77), Expect = 0.23 Identities = 61/251 (24%), Positives = 83/251 (33%), Gaps = 48/251 (19%) Query: 36 ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV---------ARATGPA 86 A + G P PP + + PP + P QG V + A GP Sbjct: 716 APQPSGGDPSPPQERNLPEGTERPPKL----CSSLPGQGPPPYVFMYPQGSPSSPAPGPP 771 Query: 87 PGPTGEREPAAGPGRSGPGP-----------------GLGSGSTSGPADSVMRQDYRAWK 129 PG AGP + P P G G GP S + A Sbjct: 772 PGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGS--YATL 829 Query: 130 VQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAP 189 +RP S R+ + P R T + F A R+G P P P ++S+ S S Sbjct: 830 TRRPGRSALVRTSPSVTPTP-ARGTPRSQSF-ALRARRKGPPP--PPPKRLSSVSGPS-- 883 Query: 190 ILGAPKRRPQSQERWPVQAAAEAR----EQEAAPGGAGG--LAAGKASGADERDTRRKAG 243 P+ P + P + A R + A P G AG AS +E + + Sbjct: 884 ----PEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGT 939 Query: 244 PAWIVRRAEGL 254 P EGL Sbjct: 940 PPSRGSSGEGL 950 Score = 32.7 bits (73), Expect = 0.67 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%) Query: 34 SEATEHPGAP-PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92 + AT P AP P P P + +L P ++ PAQG V P+P Sbjct: 1012 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSL-----PAQG----VPTPLAPSPAMQPP 1062 Query: 93 REPAAGPGRSGPGPGLGSGSTSGPA 117 P GPG +G T PA Sbjct: 1063 VPPCPGPGLESSAASRWNGETEPPA 1087 >gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] Length = 416 Score = 44.7 bits (104), Expect = 2e-04 Identities = 61/257 (23%), Positives = 84/257 (32%), Gaps = 29/257 (11%) Query: 34 SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93 S ++ P PQ PPPQ QP PP P G G GP + Sbjct: 170 SRSSRSPPGKPQGPPPQGGNQPQ-GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG 228 Query: 94 EPAAGPGRSGPG-----PGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQ 144 + + RS PG P G GP + K Q P P +P+ Sbjct: 229 DNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-P 287 Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQS 200 P R ++ P P+ G+ P P P Q + P P +PQ Sbjct: 288 PQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 347 Query: 201 QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260 P Q +++R + P GK G +++ GP A G + Sbjct: 348 P---PPQGGSKSRSARSPP--------GKPQGPPQQEGNNPQGPP---PPAGGNPQQPQA 393 Query: 261 LPAAQAQVQATGPEAGR 277 PA Q Q P+ GR Sbjct: 394 PPAGQPQGPPRPPQGGR 410 Score = 36.6 bits (83), Expect = 0.046 Identities = 48/198 (24%), Positives = 65/198 (32%), Gaps = 19/198 (9%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAPGPTGERE 94 P PQ PPPQ QP PP + P QG + GP P R Sbjct: 53 PPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS 110 Query: 95 PAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQPSDAPF 150 P + PG+ P G GP + K Q P P +P+ P Sbjct: 111 PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-PPQGDNK 169 Query: 151 ERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQSQERWPV 206 R ++ P P+ G+ P P P Q + P P +PQ P Sbjct: 170 SRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP---PP 226 Query: 207 QAAAEAREQEAAPGGAGG 224 Q +++ + PG G Sbjct: 227 QGDNKSQSARSPPGKPQG 244 Score = 35.8 bits (81), Expect = 0.079 Identities = 49/205 (23%), Positives = 67/205 (32%), Gaps = 20/205 (9%) Query: 34 SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAP- 87 S + P PQ PPPQ QP PP + P QG + GP P Sbjct: 108 SRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGPPPPGKPQGPPPQ 165 Query: 88 GPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEY 143 G R + PG+ P G GP + K Q P P +P+ Sbjct: 166 GDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP- 224 Query: 144 QPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQ 199 P + + P P+ G+ P P P Q + P P +PQ Sbjct: 225 PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 284 Query: 200 SQERWPVQAAAEAREQEAAPGGAGG 224 P Q +++R + PG G Sbjct: 285 GP---PPQGGSKSRSSRSPPGKPQG 306 >gi|153792074 proline rich 12 [Homo sapiens] Length = 2036 Score = 44.7 bits (104), Expect = 2e-04 Identities = 96/401 (23%), Positives = 146/401 (36%), Gaps = 86/401 (21%) Query: 61 SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120 S+ A++ P G D + GP P AA PG P PGL S +++G + Sbjct: 1399 SSAISALDDPPLAGPKDT-STPDGPPLAPA-----AAVPGPP-PLPGLPSANSNGTPEPP 1451 Query: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180 + ++ P P+ P+ + P P + A P P P +P P Sbjct: 1452 LLEEKPP---PTPPPAPTPQPQPPPPPPPPQPALPSPPPLVA-PTPSSPPPPPLPPPPPP 1507 Query: 181 SAASQ------ASAPILGAPKR----RPQSQERWPVQAAAEAREQE-AAPGGAGGLAAGK 229 + S A+AP+ P+ P+ E + A++QE AA G AG+ Sbjct: 1508 AMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGE 1567 Query: 230 ASGAD---ERD-----------------TRRKAGPAWIVRRAEGLGHEQTP-LPAAQAQV 268 + G ERD T R+ P W V++A L + TP + Q Q Sbjct: 1568 SGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKA--LLQKFTPEIKDGQRQF 1625 Query: 269 QATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328 AT G DA NR R V + + ++ R KP ++PP Sbjct: 1626 CATSNYLGY---FGDAKNRYQRLYVKFLENVNKKDYVRVCA---------RKPWHRPP-- 1671 Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTS 388 + G+A P +A S P PPK P + P+KT+ Sbjct: 1672 -------VPVRRSGQAKNPVSAGGS-----------SAP---PPKAPAPPPKPETPEKTT 1710 Query: 389 ASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKE 429 + P +Q + + E PS +P +KE+ KE Sbjct: 1711 SEKPP------EQTPETAMPEPPAPEKPSLLRPVEKEKEKE 1745 Score = 35.0 bits (79), Expect = 0.14 Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99 P PQPPPP QPAL P + P L P+P P PAA P Sbjct: 1465 PTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPP--PPPPAAAP 1522 Query: 100 GRSGP 104 + P Sbjct: 1523 LAAPP 1527 Score = 34.3 bits (77), Expect = 0.23 Identities = 29/90 (32%), Positives = 35/90 (38%), Gaps = 14/90 (15%) Query: 34 SEATEHPGAPPQPP--PPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTG 91 S+A + G PPQPP PP P A + QG+L V P P Sbjct: 470 SKAPSYSGGPPQPPSGPPP--------PGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHS 521 Query: 92 EREPAAGPGRS---GPGPGL-GSGSTSGPA 117 + P A P S G P L G G GP+ Sbjct: 522 QGLPTASPSLSYSTGHSPALSGHGGGWGPS 551 Score = 33.9 bits (76), Expect = 0.30 Identities = 28/94 (29%), Positives = 38/94 (40%), Gaps = 25/94 (26%) Query: 41 GAPPQPPPPQQ----------------QAQPALAPPSARAVAIETQPAQGELDAVARATG 84 GA P PPPP++ AQP PP A A+ G ++ Sbjct: 270 GAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQ-HYLSCGGSYPSMGHRAN 328 Query: 85 PAPGPTGEREPAAG---PGRSGPGPGLGSGSTSG 115 A P G EP+ G P ++GP SG+T+G Sbjct: 329 LACSPLGGGEPSPGAGEPSKAGP-----SGATAG 357 Score = 32.0 bits (71), Expect = 1.1 Identities = 24/79 (30%), Positives = 29/79 (36%), Gaps = 5/79 (6%) Query: 41 GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100 G +PPPP+ A P A A T A G A +A P G+ + GP Sbjct: 401 GGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSP-----GQPQGLLGPQ 455 Query: 101 RSGPGPGLGSGSTSGPADS 119 G G G G A S Sbjct: 456 AYGQGFGGGQAQDLSKAPS 474 Score = 31.6 bits (70), Expect = 1.5 Identities = 27/117 (23%), Positives = 36/117 (30%), Gaps = 10/117 (8%) Query: 42 APPQPPPPQQQAQPA----LAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER---- 93 +PP PPP Q QP L + + P +L + P+P P+ + Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVH 822 Query: 94 --EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA 148 EPA G P P P + P P RP P A Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879 Score = 31.6 bits (70), Expect = 1.5 Identities = 24/84 (28%), Positives = 30/84 (35%), Gaps = 12/84 (14%) Query: 24 IAVPLVFTKYSEATEHPGAPPQPPPPQQQAQ-----------PALAPPSAR-AVAIETQP 71 + V L+ + P PP PPPP Q PA P R +++ Sbjct: 819 VGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPG 878 Query: 72 AQGELDAVARATGPAPGPTGEREP 95 A EL PAPG TG P Sbjct: 879 AMQELLGALEPLPPAPGDTGVGPP 902 Score = 30.4 bits (67), Expect = 3.3 Identities = 65/262 (24%), Positives = 82/262 (31%), Gaps = 65/262 (24%) Query: 40 PGAPPQPPPPQQQAQP--ALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAA 97 PG P PPPP+ LA SA A A E Q + +G APGP Sbjct: 229 PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQ-----LYNFSGAAPGP-------- 275 Query: 98 GPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQ 157 P ++ RQD QRP + P P P Y Sbjct: 276 ----------------PPPERALPRQDTVIKHYQRPASAQPP-----PPPPPAHALQHY- 313 Query: 158 KDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRP---QSQERWPVQAAAEARE 214 L G +P + A+ A +P LG + P + + P A A A Sbjct: 314 -------LSCGGSYPSMG-----HRANLACSP-LGGGEPSPGAGEPSKAGPSGATAGASG 360 Query: 215 QEAAPGGAGGLAAGKASGADE---RDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQ-- 269 + P AGG AG G + K G A G P A + Q Sbjct: 361 RATGPEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSL 420 Query: 270 -------ATGPEAGRGRAAADA 284 ATG +G G A A Sbjct: 421 GGPAAAYATGKASGAGGAGGQA 442 Score = 29.6 bits (65), Expect = 5.7 Identities = 13/32 (40%), Positives = 13/32 (40%) Query: 40 PGAPPQPPPPQQQAQPALAPPSARAVAIETQP 71 P P PPPP A P APP A P Sbjct: 1507 PAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDP 1538 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.309 0.126 0.377 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,847,839 Number of Sequences: 37866 Number of extensions: 1328877 Number of successful extensions: 19648 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 309 Number of HSP's successfully gapped in prelim test: 1329 Number of HSP's that attempted gapping in prelim test: 11352 Number of HSP's gapped (non-prelim): 7414 length of query: 439 length of database: 18,247,518 effective HSP length: 105 effective length of query: 334 effective length of database: 14,271,588 effective search space: 4766710392 effective search space used: 4766710392 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.