Guide to the Human Genome
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Search of human proteins with 48375167

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48375167 microtubule-associated protein 6 isoform 2 [Homo
sapiens]
         (439 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48375167 microtubule-associated protein 6 isoform 2 [Homo sap...   896   0.0  
gi|48375173 microtubule-associated protein 6 isoform 1 [Homo sap...   896   0.0  
gi|13376306 MAP6 domain containing 1 [Homo sapiens]                    77   4e-14
gi|169207312 PREDICTED: hypothetical protein [Homo sapiens]            60   4e-09
gi|239750650 PREDICTED: hypothetical protein [Homo sapiens]            60   4e-09
gi|89037350 PREDICTED: hypothetical protein [Homo sapiens]             60   4e-09
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    54   2e-07
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    52   1e-06
gi|112421108 capicua homolog [Homo sapiens]                            52   1e-06
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         51   2e-06
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    50   3e-06
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    50   3e-06
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    50   3e-06
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    50   3e-06
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     50   4e-06
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    50   5e-06
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    49   9e-06
gi|116256464 hypothetical protein LOC343990 [Homo sapiens]             49   1e-05
gi|30089916 phosphofurin acidic cluster sorting protein 1 [Homo ...    47   3e-05
gi|4506321 protein tyrosine phosphatase, receptor type, N precur...    46   8e-05
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    46   8e-05
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   45   1e-04
gi|153791535 general control of amino acid synthesis 5-like 2 [H...    45   1e-04
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]                45   1e-04
gi|73476377 LBXCOR1 homolog [Homo sapiens]                             45   1e-04
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 45   2e-04
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]       45   2e-04
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]       45   2e-04
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     45   2e-04
gi|153792074 proline rich 12 [Homo sapiens]                            45   2e-04

>gi|48375167 microtubule-associated protein 6 isoform 2 [Homo
           sapiens]
          Length = 439

 Score =  896 bits (2316), Expect = 0.0
 Identities = 439/439 (100%), Positives = 439/439 (100%)

Query: 1   MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60
           MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP
Sbjct: 1   MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60

Query: 61  SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120
           SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV
Sbjct: 61  SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120

Query: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180
           MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI
Sbjct: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180

Query: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240
           SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR
Sbjct: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240

Query: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300
           KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS
Sbjct: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300

Query: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360
           YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI
Sbjct: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360

Query: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420
           RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK
Sbjct: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420

Query: 421 PDDKEQSKEMNNKLAEAKE 439
           PDDKEQSKEMNNKLAEAKE
Sbjct: 421 PDDKEQSKEMNNKLAEAKE 439


>gi|48375173 microtubule-associated protein 6 isoform 1 [Homo
           sapiens]
          Length = 813

 Score =  896 bits (2316), Expect = 0.0
 Identities = 439/439 (100%), Positives = 439/439 (100%)

Query: 1   MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60
           MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP
Sbjct: 1   MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPP 60

Query: 61  SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120
           SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV
Sbjct: 61  SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120

Query: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180
           MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI
Sbjct: 121 MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180

Query: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240
           SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR
Sbjct: 181 SAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRR 240

Query: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300
           KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS
Sbjct: 241 KAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSS 300

Query: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360
           YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI
Sbjct: 301 YRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRI 360

Query: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420
           RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK
Sbjct: 361 RSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTK 420

Query: 421 PDDKEQSKEMNNKLAEAKE 439
           PDDKEQSKEMNNKLAEAKE
Sbjct: 421 PDDKEQSKEMNNKLAEAKE 439


>gi|13376306 MAP6 domain containing 1 [Homo sapiens]
          Length = 199

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 20/156 (12%)

Query: 1   MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEA-TEHPG----APPQPPPPQQQAQP 55
           MAWPCI+R CC+AR WNQLD++D+AVPL    YS+  +E PG    A  +  PP      
Sbjct: 1   MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDLDSEEPGTGGAASRRGQPPAGARDS 60

Query: 56  ALAPPSA---RAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPG----- 107
               P     R   + T PA G  D      G  PG  G R  ++    + P PG     
Sbjct: 61  GRDVPLTQYQRDFGLWTTPA-GPKDP---PPGRGPGAGGRRGKSSAQSSAPPAPGARGVY 116

Query: 108 ---LGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140
              +G    +    +  RQ+++AW   +P  S + +
Sbjct: 117 VLPIGDADAAAAVTTSYRQEFQAWTGVKPSRSTKTK 152



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 16/30 (53%), Positives = 23/30 (76%)

Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKP 321
           + A+AV++SYR EF+AWT +KP +  K KP
Sbjct: 124 DAAAAVTTSYRQEFQAWTGVKPSRSTKTKP 153


>gi|169207312 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 414

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%)

Query: 16  WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73
           W +L       P   +  +     PG  PQP    Q  +P   + PP    V +   P +
Sbjct: 74  WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133

Query: 74  GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117
             L A ARA G     P+P    E  PA+    SG           PGP  G GS     
Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191

Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171
           + + +   R      PE    P CR  S       P     + +K  R  PLPR      
Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251

Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227
             P        S++  A  P   +P R P  +   P  A  E R    +P  A  GG ++
Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308

Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277
           G  SG D +     A PA     A G      P  + +    A GP + R
Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358


>gi|239750650 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 414

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%)

Query: 16  WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73
           W +L       P   +  +     PG  PQP    Q  +P   + PP    V +   P +
Sbjct: 74  WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133

Query: 74  GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117
             L A ARA G     P+P    E  PA+    SG           PGP  G GS     
Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191

Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171
           + + +   R      PE    P CR  S       P     + +K  R  PLPR      
Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251

Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227
             P        S++  A  P   +P R P  +   P  A  E R    +P  A  GG ++
Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308

Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277
           G  SG D +     A PA     A G      P  + +    A GP + R
Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358


>gi|89037350 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 414

 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 76/290 (26%), Positives = 101/290 (34%), Gaps = 33/290 (11%)

Query: 16  WNQLDKADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPA--LAPPSARAVAIETQPAQ 73
           W +L       P   +  +     PG  PQP    Q  +P   + PP    V +   P +
Sbjct: 74  WRRLSADRWPRPASLSPRAALASAPGQKPQPARQAQLPRPVSGVRPPPRGRVGLSQAPGR 133

Query: 74  GELDAVARATG-----PAPGPTGEREPAAGPGRSG-----------PGPGLGSGSTSGPA 117
             L A ARA G     P+P    E  PA+    SG           PGP  G GS     
Sbjct: 134 -PLGACARAKGIRLVNPSPPRPPEPIPASAAVTSGLTARGPNTSATPGPQKGRGSAER-T 191

Query: 118 DSVMRQDYRAWKVQRPE----PSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH-- 171
           + + +   R      PE    P CR  S       P     + +K  R  PLPR      
Sbjct: 192 NHIPKDKQRVAAPPPPERPRVPFCRGSSGLSVPTPPEHAGGRRKKFTRTRPLPRTSSFLS 251

Query: 172 --PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGA--GGLAA 227
             P        S++  A  P   +P R P  +   P  A  E R    +P  A  GG ++
Sbjct: 252 EVPSTRPLCATSSSHSAPLPFFWSPLRNPSPR---PAPACGELRLGRLSPPRADTGGSSS 308

Query: 228 GKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGR 277
           G  SG D +     A PA     A G      P  + +    A GP + R
Sbjct: 309 GGCSGPDSKHRTLPAPPAPTAWPAAGAPGAPNPAESRRGPGPAQGPPSRR 358


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 73/262 (27%), Positives = 86/262 (32%), Gaps = 42/262 (16%)

Query: 40  PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA--- 96
           P  P  P PP  + +P   PP   A +    PA     A A A GP P P G  +PA   
Sbjct: 113 PLVPAGPAPPAAKLRP---PPEGSAGSCAPVPA-----AAAVAAGPEPAPAGPAKPAGPA 164

Query: 97  -----AGPGRS---GPGPGLGSGSTSGPADSVMRQDYRAW----KVQRPEPSC--RPRSE 142
                AGPG     GPGPG G G  +GP  +       A         P  S      + 
Sbjct: 165 ALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAA 224

Query: 143 YQPSDAPFERETQYQKD----FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRP 198
             P   P    T  Q        A P P     P  P P   +AA     P      R P
Sbjct: 225 LLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPP 284

Query: 199 QSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQ 258
                 P  A A      A  GG+ G A   A  A         GPA +  +        
Sbjct: 285 GHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAA--------GGPAGVSGQPGPGAAAA 336

Query: 259 TPLPAAQAQ-----VQATGPEA 275
            P P  +A+     VQA  P A
Sbjct: 337 APAPGVKAESPKRVVQAAPPAA 358



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 61/233 (26%), Positives = 79/233 (33%), Gaps = 26/233 (11%)

Query: 38  EHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPG-PTGEREPA 96
           E P    Q  PP  Q   A  P S  A  +     QG L + A    PAPG PTG  + A
Sbjct: 345 ESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGA 404

Query: 97  AGP-----GRSGPGPGLGSGSTSGPADSVMR------QDYRAWKVQRPEPSCRPRSEY-Q 144
           AG       R+      G  +T  P     R              Q P      RSE  Q
Sbjct: 405 AGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464

Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIP---KPVQISAASQASAPILGAPKR----- 196
               P +   Q Q    A P       P  P    PVQIS       PI+          
Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTII 524

Query: 197 RPQSQERWPVQAAAEAR-----EQEAAPGGAGGLAAGKASGADERDTRRKAGP 244
           +  SQ +  VQ +A  +     + +   GGA   A+   + A +  T ++  P
Sbjct: 525 KQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVP 577



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 13/89 (14%)

Query: 36  ATEHPGAPPQPPPPQQQAQPALA--------PPSARAVAIETQPAQGELDAVARATGPAP 87
           A   P AP   PPP   A   LA        PP+A A A+    A     +   A  PAP
Sbjct: 259 AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTA-APAVPPPAAAQNGGSAGAAPAPAP 317

Query: 88  ---GPTG-EREPAAGPGRSGPGPGLGSGS 112
              GP G   +P  G   + P PG+ + S
Sbjct: 318 AAGGPAGVSGQPGPGAAAAAPAPGVKAES 346


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 57/209 (27%), Positives = 72/209 (34%), Gaps = 22/209 (10%)

Query: 43  PPQPPPPQQQA--QPALAPPSARAVAIETQPAQGELDAVARATGPAPG-----PTGEREP 95
           PPQ PPPQQ    QP   P   +       P       VA+  GPAPG     P     P
Sbjct: 73  PPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAP 132

Query: 96  AAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQ 155
            A P  SG  PG G G T  P  +V      A     P  S  P +  Q    P      
Sbjct: 133 PATPPTSGAPPGSGPGPTPTPPPAVTSAPPGA-PPPTPPSSGVPTTPPQAGGPPPPPAAV 191

Query: 156 YQKDFRAWPLPRRGDHPWIPKPVQISAASQ-ASAPILGAPKRRPQSQERWPVQAAA---- 210
                   P P++G  P  PK  ++    +    P L  P   P+   R   +       
Sbjct: 192 PGPG----PGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQH 247

Query: 211 -----EAREQEAAPGGAGGLAAGKASGAD 234
                +   Q   PGG GG +  K S ++
Sbjct: 248 HPPYHQQHHQGPPPGGPGGRSEEKISDSE 276



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 32/82 (39%), Positives = 35/82 (42%), Gaps = 6/82 (7%)

Query: 40  PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQ--GELDAVARATGPAPGP---TGERE 94
           PG  P PPP    A P   PP+  +  + T P Q  G     A   GP PGP    G   
Sbjct: 147 PGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGG 206

Query: 95  PAAGPGRSGPGPGLGSG-STSG 115
           P  G    GP PG G G ST G
Sbjct: 207 PKGGKMPGGPKPGGGPGLSTPG 228


>gi|112421108 capicua homolog [Homo sapiens]
          Length = 1608

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/411 (23%), Positives = 139/411 (33%), Gaps = 76/411 (18%)

Query: 27   PLVFTKYSEATEHPGAP---------PQPPPPQQQAQPALAPPS-ARAVAIETQPAQGEL 76
            P+   +   A   PG P         P P      AQP+ APPS    VA  T P     
Sbjct: 1074 PVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAPLAQPSQAPPSLVYTVATSTTPPA--- 1130

Query: 77   DAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPS 136
             A     GP P P       A P  + P P   +GS        M     A K QRP P 
Sbjct: 1131 -ATILPKGP-PAPA-----TATPAPTSPFPSATAGS--------MTYSLVAPKAQRPSPK 1175

Query: 137  CRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKR 196
               + +   +  P     +     R  P PR+   P  P PV+   A ++       P  
Sbjct: 1176 APQKVKAAIASIPV-GSFEAGASGRPGPAPRQ---PLEPGPVREPTAPESELEGQPTPPA 1231

Query: 197  RPQSQERWPVQAAAE------AREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIV-- 248
             P   E W   A +       A E+ +A G     +   +S +D           W V  
Sbjct: 1232 PPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSD-----------WRVPG 1280

Query: 249  RRAEGLGHEQTPLPAAQAQVQATG--PEAGRGRAAADALNRQIREEVASAVSSSYRNEFR 306
            +  E  G   TP   A A   A G   E+  GRAA D   R+        V         
Sbjct: 1281 QGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVK-------- 1332

Query: 307  AWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSE 366
                   V+P   K  +   D++++ E  +  +F   A  P     +V+    ++SL + 
Sbjct: 1333 -------VRPPPLKKTFDSVDNRVLSEVDFEERF---AELPEFRPEEVLPSPTLQSLATS 1382

Query: 367  P---FKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAE 414
            P        K  K S       +   S  P RK + + + S +    KSA+
Sbjct: 1383 PRAILGSYRKKRKNSTDLDSAPEDPTS--PKRKMRRRSSCSSEPNTPKSAK 1431



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 48/161 (29%), Positives = 65/161 (40%), Gaps = 37/161 (22%)

Query: 42  APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGR 101
           AP QP P  Q ++     P++  VA        E  AVA      PG TG  +P   PG 
Sbjct: 45  APSQPDPSVQPSEAQ--QPASHPVASNQSKEPAESAAVAHER--PPGGTGSADPERPPGA 100

Query: 102 S-----GPGP---------GLGSGST-----SGP-----ADSVMRQDY-------RAWKV 130
           +     GPGP         G G   T     SGP      DS    D+        + ++
Sbjct: 101 TCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEI 160

Query: 131 QRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171
           Q P P  + R++   S  P ER++  +KD R+ P  R  DH
Sbjct: 161 QLPLPPGKRRTQ-SLSALPKERDSSSEKDGRS-PNKREKDH 199



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 29/84 (34%), Positives = 36/84 (42%), Gaps = 7/84 (8%)

Query: 21   KADIAVPLVFTKYSEATEHPG-APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV 79
            KA IA   V +  + A+  PG AP QP  P    +P    P +      T PA   L   
Sbjct: 1181 KAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTA--PESELEGQPTPPAPPPLPET 1238

Query: 80   ----ARATGPAPGPTGEREPAAGP 99
                AR++ P P P  ER  A GP
Sbjct: 1239 WTPTARSSPPLPPPAEERTSAKGP 1262



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 26/79 (32%), Positives = 31/79 (39%), Gaps = 6/79 (7%)

Query: 40   PGAP---PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA 96
            PGA    P PPP    A PA  P  A      T P+     A A    P P  +G  +P 
Sbjct: 1529 PGAEAPLPVPPPTGTAAAPAPTPSPAGGPD-PTSPSSDSGTAQAAPPLPPPPESGPGQPG 1587

Query: 97   --AGPGRSGPGPGLGSGST 113
                P  S P PG  + +T
Sbjct: 1588 WEGAPQPSPPPPGPSTAAT 1606



 Score = 28.9 bits (63), Expect = 9.7
 Identities = 27/96 (28%), Positives = 38/96 (39%), Gaps = 9/96 (9%)

Query: 43  PPQPP-PPQQQAQPALAPPSARAVAIETQPAQGELDAVAR---ATGPAPGPTGEREPAAG 98
           PP PP PP    +   + PS+ A    + PA     A       +G        +   AG
Sbjct: 514 PPGPPDPPVAFGKGYGSAPSSSA----SSPASSSASAATSFSLGSGTFKAQESGQGSTAG 569

Query: 99  PGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPE 134
           P R  P PG G  +T   A   +  D   ++ +RPE
Sbjct: 570 PLRPPP-PGAGGPATPSKATRFLPMDPATFRRKRPE 604



 Score = 28.9 bits (63), Expect = 9.7
 Identities = 21/66 (31%), Positives = 26/66 (39%), Gaps = 11/66 (16%)

Query: 51   QQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGS 110
            Q A P   PP A A  +   P  G       A  PAP P+    PA GP  + P    G+
Sbjct: 1520 QAATPTEQPPGAEA-PLPVPPPTGT------AAAPAPTPS----PAGGPDPTSPSSDSGT 1568

Query: 111  GSTSGP 116
               + P
Sbjct: 1569 AQAAPP 1574


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 98/406 (24%), Positives = 137/406 (33%), Gaps = 90/406 (22%)

Query: 31   TKYSEATEHPGAPPQPP----PPQQQAQPALAPP-------SARAVAIETQPAQGELDAV 79
            T+  E    P  PP PP    PP  Q QP   PP        + A  +E Q         
Sbjct: 764  TQEEEKKPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGA 823

Query: 80   ARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRP 139
            A +T P P PT +  P    G +   P   + S  G                 P+PS   
Sbjct: 824  AVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQG----------------SPQPSASS 867

Query: 140  RSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQ 199
             S++  S  P+ RE             R G+ P +P P+          P L  P  R +
Sbjct: 868  SSQFSTSGGPWARER------------RAGEEP-VPGPM----TPTQPPPPLSLPPARSE 910

Query: 200  SQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT 259
            S+    +  A E   +               S  D  D    A PA         G E+ 
Sbjct: 911  SEVLEEISRACETLVERVG-----------RSATDPADPVDTAEPA-------DSGTERL 952

Query: 260  PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPI-- 317
             LP AQA+      EAG   A + +  R+ +E         +R   RA  D    +P   
Sbjct: 953  -LPPAQAK-----EEAGGVAAVSGSCKRRQKEH-----QKEHRRHRRACKDSVGRRPREG 1001

Query: 318  KAKPQYKPPDDK----MVHETSYSAQFKG-EASKPTTADNKVIDRRRIRSLYSEPFKEPP 372
            +AK + K P +K    + +    S + +G E S+P        D              PP
Sbjct: 1002 RAKAKAKVPKEKSRRVLGNLDLQSEEIQGREKSRP--------DLGGASKAKPPTAPAPP 1053

Query: 373  KVEKPSVQSSKPKKTSASHKPTRKAKDKQAVS-GQAAKKKS-AEGP 416
                PS Q + P  +    K   +A     VS     K +S +EGP
Sbjct: 1054 SAPAPSAQPTPPSASVPGKKAREEAPGPPGVSRADMLKLRSLSEGP 1099



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 65/300 (21%), Positives = 104/300 (34%), Gaps = 31/300 (10%)

Query: 43  PPQP-PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPA-AGPG 100
           PP+P PPP    +  L PP++R  ++ TQ +          T  +   +G    + AGP 
Sbjct: 511 PPRPAPPPLPHREGFLGPPASR-FSVGTQDSHTPPTPPTPTTSSSNSNSGSHSSSPAGPV 569

Query: 101 RSGPGPGLGSG---STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQ 157
              P P L          P+ +   QD     +    P   P S +Q +   F R    +
Sbjct: 570 SFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLTLALPPAPPSSCHQNTSGSFRRPESPR 629

Query: 158 KDFRAWPLPRRGDHPWIPKPVQISAASQASAPILG-APKRRPQSQERWPV---QAAAEAR 213
                   P  G     P P  +S A Q   P +G  P R P+  +  P        E  
Sbjct: 630 PRVSFPKTPEVGPG---PPPGPLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQFEEPA 686

Query: 214 EQEAAPGGAGGL--AAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQAT 271
           E +  P G   +     ++   +E   + +AG A            Q PL    A +Q+ 
Sbjct: 687 EFKILPDGLANIMKMLDESIRKEEEQQQHEAGVA-----------PQPPLKEPFASLQSP 735

Query: 272 GPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPI-----KAKPQYKPP 326
            P        A A+         +  +++   E +    + P  P+      ++PQ  PP
Sbjct: 736 FPTDTAPTTTAPAVAVTTTTTTTTTTTATQEEEKKPPPALPPPPPLAKFPPPSQPQPPPP 795


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%)

Query: 22  ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81
           A +    V TK S A +   AP +      Q +    PP+ RA   E +    E  + + 
Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280

Query: 82  ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133
              PA   +  +          A+ P +  PG G  + +  G A +V  Q     K  +P
Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335

Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191
           E      SE + SD+  E ET   K      L  +       K  Q+ AAS  +  +P  
Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384

Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250
           GA    P        +A A  RE+++        ++ ++   +E   + K +G A  VR 
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310
           A     E     AA A  + TGP      AA   + +Q  +  +S+  S    E  A  +
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493

Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369
              VKP+   PQ KP     +      A         P T   +V          SE   
Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553

Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425
           +    E P+  +   +K+  +    KPT   AK     +G  A +  AE     KP D  
Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608

Query: 426 QSKEMNNKLAEAKE 439
           +S E ++  A+++E
Sbjct: 609 ESSEESSDSADSEE 622



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%)

Query: 52  QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111
           + +P++ P   +A ++ T+      ++ AR   PAPG  G+  P    G   P       
Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261

Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171
                         RA K +    S    SE +  +AP    +Q +              
Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294

Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231
               K +Q+ AAS   AP  G P +                    A PG AG +A+   +
Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332

Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291
           G  E D+   +              E+TP   A  Q +A+G  +  G A+A A     +E
Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380

Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351
                 +              P  P K  P           E S S+  + ++ +   A 
Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426

Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411
            K             P  + P+V   S  + +  +  A+  P RK     A      +++
Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473

Query: 412 SAEGPSTTKPDDKEQSKEMN 431
            +   S     D+E    MN
Sbjct: 474 DSRSSSEESDSDREALAAMN 493



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%)

Query: 41  GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94
           GA P PP     A P+         S  +    +  + GE+  AVA A   + G   + +
Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579

Query: 95  PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153
           P + P +  P         +GP          A +V+  +P     S  + SD A  E  
Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623

Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213
                  +A P  +       PK    +A+++       AP R      R    A + A 
Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677

Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269
              A  GG    A   +S  +      K G A  V +A+ +G     +   +P   +  Q
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328
            T P   G+       +  + +E+  S+   S   E  A        P + K   K    
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790

Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377
           K     + +   KG  S P     KV+     ++    P K  P V  P           
Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845

Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437
           SV S      +A+   T   +D  +   ++  ++ AE  +  KP  K  + ++   LA A
Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903

Query: 438 KE 439
           KE
Sbjct: 904 KE 905



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 57/255 (22%), Positives = 90/255 (35%), Gaps = 52/255 (20%)

Query: 214  EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT-------------- 259
            +QEA P  A G+ + K  G   ++      P    +  +G G+ Q               
Sbjct: 1207 KQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLL 1263

Query: 260  --PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPV--- 314
              P P  +AQVQA+             L   + +E    V ++  +  + W   K     
Sbjct: 1264 GQPWPLNEAQVQAS---------VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1314

Query: 315  -KPIKAKPQYKPPD--------DKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYS 365
             +P    P+ K           +  V     S   KG+A K   A   V +++   SL S
Sbjct: 1315 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA-KRDKASGDVKEKKGKGSLGS 1373

Query: 366  EPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPST 418
            +  K+ P+ E             S PK      K  ++ KDK+    +  KKK A+  ST
Sbjct: 1374 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKE----KKEKKKKAKKAST 1429

Query: 419  TKPDDKEQSKEMNNK 433
               +   Q K+   K
Sbjct: 1430 KDSESPSQKKKKKKK 1444



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G P +      +        +  A A+    A G+   V  A+ PA     +    A PG
Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
           ++GP                     +A   +R E S   +S  + SD+  E   Q +   
Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431

Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220
           +A               V+ ++A    +P  GA    P  ++  P  A  +  +QE    
Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472

Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276
                     S ++E D+ R+A  A    + + LG      PA+   +   G  AG    
Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315
                                    ++D+ + ++   VA A   S  N  +A     P K
Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586

Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367
             P KA P        KP D+    E S  +    EA    TA  +     +I    + P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645

Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423
            K       KV    V +  P+K   +  P   A    AV+G    ++ AE  S+++  D
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700

Query: 424 KEQSK 428
            E+ K
Sbjct: 701 SEEEK 705


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%)

Query: 22  ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81
           A +    V TK S A +   AP +      Q +    PP+ RA   E +    E  + + 
Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280

Query: 82  ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133
              PA   +  +          A+ P +  PG G  + +  G A +V  Q     K  +P
Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335

Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191
           E      SE + SD+  E ET   K      L  +       K  Q+ AAS  +  +P  
Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384

Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250
           GA    P        +A A  RE+++        ++ ++   +E   + K +G A  VR 
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310
           A     E     AA A  + TGP      AA   + +Q  +  +S+  S    E  A  +
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493

Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369
              VKP+   PQ KP     +      A         P T   +V          SE   
Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553

Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425
           +    E P+  +   +K+  +    KPT   AK     +G  A +  AE     KP D  
Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608

Query: 426 QSKEMNNKLAEAKE 439
           +S E ++  A+++E
Sbjct: 609 ESSEESSDSADSEE 622



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%)

Query: 52  QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111
           + +P++ P   +A ++ T+      ++ AR   PAPG  G+  P    G   P       
Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261

Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171
                         RA K +    S    SE +  +AP    +Q +              
Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294

Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231
               K +Q+ AAS   AP  G P +                    A PG AG +A+   +
Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332

Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291
           G  E D+   +              E+TP   A  Q +A+G  +  G A+A A     +E
Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380

Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351
                 +              P  P K  P           E S S+  + ++ +   A 
Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426

Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411
            K             P  + P+V   S  + +  +  A+  P RK     A      +++
Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473

Query: 412 SAEGPSTTKPDDKEQSKEMN 431
            +   S     D+E    MN
Sbjct: 474 DSRSSSEESDSDREALAAMN 493



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 102/457 (22%), Positives = 154/457 (33%), Gaps = 99/457 (21%)

Query: 25   AVPLVFTKYSEATEHPGAPPQPPPPQQQAQ---PALAPPSARAVAIET----QPAQGELD 77
            A+ ++  K SEA + P A  QP      A    PA +P S    A  T    +P   E+ 
Sbjct: 1076 ALKVLAQKASEA-QPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQ 1134

Query: 78   AVARATGPAPGPTGEREPAAGPGRSGPGP-GLGSGSTSGPADSVMRQDYRAWKVQRPEPS 136
               +A   +       + ++G    G GP G  S  T GP  S                 
Sbjct: 1135 QATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPS----------------- 1177

Query: 137  CRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKR 196
               R+E    +   E     + D  A   P +        P    A SQAS       K 
Sbjct: 1178 ---RTETLVEETAAESS---EDDVVA---PSQSLLSGYMTPGLTPANSQAS-------KA 1221

Query: 197  RPQSQERWPVQAAAEARE-----QEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRA 251
             P+      V +   A++     QEA P  A G+ + K  G   ++      P    +  
Sbjct: 1222 TPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPK 1278

Query: 252  EGLGHEQT----------------PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVAS 295
            +G G+ Q                 P P  +AQVQA+             L   + +E   
Sbjct: 1279 KGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQAS---------VVKVLTELLEQERKK 1329

Query: 296  AVSSSYRNEFRAWTDIKPV----KPIKAKPQYKPPD--------DKMVHETSYSAQFKGE 343
             V ++  +  + W   K      +P    P+ K           +  V     S   KG+
Sbjct: 1330 VVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGK 1389

Query: 344  ASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRK 396
            A K   A   V +++   SL S+  K+ P+ E             S PK      K  ++
Sbjct: 1390 A-KRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1448

Query: 397  AKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNK 433
             KDK+    +  KKK A+  ST   +   Q K+   K
Sbjct: 1449 KKDKE----KKEKKKKAKKASTKDSESPSQKKKKKKK 1481



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%)

Query: 41  GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94
           GA P PP     A P+         S  +    +  + GE+  AVA A   + G   + +
Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579

Query: 95  PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153
           P + P +  P         +GP          A +V+  +P     S  + SD A  E  
Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623

Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213
                  +A P  +       PK    +A+++       AP R      R    A + A 
Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677

Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269
              A  GG    A   +S  +      K G A  V +A+ +G     +   +P   +  Q
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328
            T P   G+       +  + +E+  S+   S   E  A        P + K   K    
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790

Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377
           K     + +   KG  S P     KV+     ++    P K  P V  P           
Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845

Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437
           SV S      +A+   T   +D  +   ++  ++ AE  +  KP  K  + ++   LA A
Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903

Query: 438 KE 439
           KE
Sbjct: 904 KE 905



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G P +      +        +  A A+    A G+   V  A+ PA     +    A PG
Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
           ++GP                     +A   +R E S   +S  + SD+  E   Q +   
Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431

Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220
           +A               V+ ++A    +P  GA    P  ++  P  A  +  +QE    
Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472

Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276
                     S ++E D+ R+A  A    + + LG      PA+   +   G  AG    
Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315
                                    ++D+ + ++   VA A   S  N  +A     P K
Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586

Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367
             P KA P        KP D+    E S  +    EA    TA  +     +I    + P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645

Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423
            K       KV    V +  P+K   +  P   A    AV+G    ++ AE  S+++  D
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700

Query: 424 KEQSK 428
            E+ K
Sbjct: 701 SEEEK 705


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%)

Query: 22  ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81
           A +    V TK S A +   AP +      Q +    PP+ RA   E +    E  + + 
Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280

Query: 82  ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133
              PA   +  +          A+ P +  PG G  + +  G A +V  Q     K  +P
Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335

Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191
           E      SE + SD+  E ET   K      L  +       K  Q+ AAS  +  +P  
Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384

Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250
           GA    P        +A A  RE+++        ++ ++   +E   + K +G A  VR 
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310
           A     E     AA A  + TGP      AA   + +Q  +  +S+  S    E  A  +
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493

Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369
              VKP+   PQ KP     +      A         P T   +V          SE   
Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553

Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425
           +    E P+  +   +K+  +    KPT   AK     +G  A +  AE     KP D  
Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608

Query: 426 QSKEMNNKLAEAKE 439
           +S E ++  A+++E
Sbjct: 609 ESSEESSDSADSEE 622



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%)

Query: 52  QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111
           + +P++ P   +A ++ T+      ++ AR   PAPG  G+  P    G   P       
Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261

Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171
                         RA K +    S    SE +  +AP    +Q +              
Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294

Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231
               K +Q+ AAS   AP  G P +                    A PG AG +A+   +
Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332

Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291
           G  E D+   +              E+TP   A  Q +A+G  +  G A+A A     +E
Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380

Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351
                 +              P  P K  P           E S S+  + ++ +   A 
Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426

Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411
            K             P  + P+V   S  + +  +  A+  P RK     A      +++
Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473

Query: 412 SAEGPSTTKPDDKEQSKEMN 431
            +   S     D+E    MN
Sbjct: 474 DSRSSSEESDSDREALAAMN 493



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%)

Query: 41  GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94
           GA P PP     A P+         S  +    +  + GE+  AVA A   + G   + +
Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579

Query: 95  PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153
           P + P +  P         +GP          A +V+  +P     S  + SD A  E  
Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623

Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213
                  +A P  +       PK    +A+++       AP R      R    A + A 
Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677

Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269
              A  GG    A   +S  +      K G A  V +A+ +G     +   +P   +  Q
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328
            T P   G+       +  + +E+  S+   S   E  A        P + K   K    
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790

Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377
           K     + +   KG  S P     KV+     ++    P K  P V  P           
Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845

Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437
           SV S      +A+   T   +D  +   ++  ++ AE  +  KP  K  + ++   LA A
Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903

Query: 438 KE 439
           KE
Sbjct: 904 KE 905



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 57/255 (22%), Positives = 90/255 (35%), Gaps = 52/255 (20%)

Query: 214  EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQT-------------- 259
            +QEA P  A G+ + K  G   ++      P    +  +G G+ Q               
Sbjct: 1206 KQEAKPQQAAGMLSPKTGG---KEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLL 1262

Query: 260  --PLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPV--- 314
              P P  +AQVQA+             L   + +E    V ++  +  + W   K     
Sbjct: 1263 GQPWPLNEAQVQAS---------VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSG 1313

Query: 315  -KPIKAKPQYKPPD--------DKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYS 365
             +P    P+ K           +  V     S   KG+A K   A   V +++   SL S
Sbjct: 1314 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKA-KRDKASGDVKEKKGKGSLGS 1372

Query: 366  EPFKEPPKVEKPSVQS-------SKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPST 418
            +  K+ P+ E             S PK      K  ++ KDK+    +  KKK A+  ST
Sbjct: 1373 QGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKE----KKEKKKKAKKAST 1428

Query: 419  TKPDDKEQSKEMNNK 433
               +   Q K+   K
Sbjct: 1429 KDSESPSQKKKKKKK 1443



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G P +      +        +  A A+    A G+   V  A+ PA     +    A PG
Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
           ++GP                     +A   +R E S   +S  + SD+  E   Q +   
Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431

Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220
           +A               V+ ++A    +P  GA    P  ++  P  A  +  +QE    
Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472

Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276
                     S ++E D+ R+A  A    + + LG      PA+   +   G  AG    
Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315
                                    ++D+ + ++   VA A   S  N  +A     P K
Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586

Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367
             P KA P        KP D+    E S  +    EA    TA  +     +I    + P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645

Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423
            K       KV    V +  P+K   +  P   A    AV+G    ++ AE  S+++  D
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700

Query: 424 KEQSK 428
            E+ K
Sbjct: 701 SEEEK 705


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 104/434 (23%), Positives = 161/434 (37%), Gaps = 48/434 (11%)

Query: 22  ADIAVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVAR 81
           A +    V TK S A +   AP +      Q +    PP+ RA   E +    E  + + 
Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESE 280

Query: 82  ATGPAPGPTGER--------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP 133
              PA   +  +          A+ P +  PG G  + +  G A +V  Q     K  +P
Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG-ATPAPPGKAGAVASQT----KAGKP 335

Query: 134 EPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQAS--APIL 191
           E      SE + SD+  E ET   K      L  +       K  Q+ AAS  +  +P  
Sbjct: 336 EEDSESSSE-ESSDS--EEETPAAKAL----LQAKAS----GKTSQVGAASAPAKESPRK 384

Query: 192 GAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRK-AGPAWIVRR 250
           GA    P        +A A  RE+++        ++ ++   +E   + K +G A  VR 
Sbjct: 385 GAAPAPPGKTGPAVAKAQAGKREEDSQS------SSEESDSEEEAPAQAKPSGKAPQVRA 438

Query: 251 AEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTD 310
           A     E     AA A  + TGP      AA   + +Q  +  +S+  S    E  A  +
Sbjct: 439 ASAPAKESPRKGAAPAPPRKTGP-----AAAQVQVGKQEEDSRSSSEESDSDREALAAMN 493

Query: 311 IKPVKPIKAKPQYKPPDDKMVHETSYSA-QFKGEASKPTTADNKVIDRRRIRSLYSEPFK 369
              VKP+   PQ KP     +      A         P T   +V          SE   
Sbjct: 494 AAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESS 553

Query: 370 EPPKVEKPSVQSSKPKKTSAS---HKPTRK-AKDKQAVSGQAAKKKSAEGPSTTKPDDKE 425
           +    E P+  +   +K+  +    KPT   AK     +G  A +  AE     KP D  
Sbjct: 554 DSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAE-----KPMDNS 608

Query: 426 QSKEMNNKLAEAKE 439
           +S E ++  A+++E
Sbjct: 609 ESSEESSDSADSEE 622



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 76/380 (20%), Positives = 123/380 (32%), Gaps = 99/380 (26%)

Query: 52  QAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSG 111
           + +P++ P   +A ++ T+      ++ AR   PAPG  G+  P    G   P       
Sbjct: 213 EGKPSVKPAQVKASSVSTK------ESPARKAAPAPGKVGDVTPQVKGGALPPAK----- 261

Query: 112 STSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDH 171
                         RA K +    S    SE +  +AP    +Q +              
Sbjct: 262 --------------RAKKPEEESESSEEGSESE-EEAPAGTRSQVKAS------------ 294

Query: 172 PWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKAS 231
               K +Q+ AAS   AP  G P +                    A PG AG +A+   +
Sbjct: 295 ---EKILQVRAAS---APAKGTPGKGATP----------------APPGKAGAVASQTKA 332

Query: 232 GADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRGRAAADALNRQIRE 291
           G  E D+   +              E+TP   A  Q +A+G  +  G A+A A     +E
Sbjct: 333 GKPEEDSESSS-------EESSDSEEETPAAKALLQAKASGKTSQVGAASAPA-----KE 380

Query: 292 EVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTAD 351
                 +              P  P K  P           E S S+  + ++ +   A 
Sbjct: 381 SPRKGAA--------------PAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQ 426

Query: 352 NKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKK 411
            K             P  + P+V   S  + +  +  A+  P RK     A      +++
Sbjct: 427 AK-------------PSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEE 473

Query: 412 SAEGPSTTKPDDKEQSKEMN 431
            +   S     D+E    MN
Sbjct: 474 DSRSSSEESDSDREALAAMN 493



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 91/422 (21%), Positives = 145/422 (34%), Gaps = 59/422 (13%)

Query: 41  GAPPQPPPPQQQAQPALA-----PPSARAVAIETQPAQGELD-AVARATGPAPGPTGERE 94
           GA P PP     A P+         S  +    +  + GE+  AVA A   + G   + +
Sbjct: 520 GAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAK 579

Query: 95  PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD-APFERE 153
           P + P +  P         +GP          A +V+  +P     S  + SD A  E  
Sbjct: 580 PTSSPAKGPP-------QKAGPV---------AVQVKAEKPMDNSESSEESSDSADSEEA 623

Query: 154 TQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213
                  +A P  +       PK    +A+++       AP R      R    A + A 
Sbjct: 624 PAAMTAAQAKPALKIPQTKACPKKTNTTASAKV------APVRVGTQAPRKAGTATSPAG 677

Query: 214 EQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGH----EQTPLPAAQAQVQ 269
              A  GG    A   +S  +      K G A  V +A+ +G     +   +P   +  Q
Sbjct: 678 SSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQ 737

Query: 270 ATGPE-AGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328
            T P   G+       +  + +E+  S+   S   E  A        P + K   K    
Sbjct: 738 GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAA-------SPAQVKTSVKKTQA 790

Query: 329 KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKP----------- 377
           K     + +   KG  S P     KV+     ++    P K  P V  P           
Sbjct: 791 KANPAAARAPSAKGTISAP----GKVV-TAAAQAKQRSPSKVKPPVRNPQNSTVLARGPA 845

Query: 378 SVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEA 437
           SV S      +A+   T   +D  +   ++  ++ AE  +  KP  K  + ++   LA A
Sbjct: 846 SVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGK--THQIRAALAPA 903

Query: 438 KE 439
           KE
Sbjct: 904 KE 905



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 89/425 (20%), Positives = 143/425 (33%), Gaps = 89/425 (20%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G P +      +        +  A A+    A G+   V  A+ PA     +    A PG
Sbjct: 333 GKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG 392

Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
           ++GP                     +A   +R E S   +S  + SD+  E   Q +   
Sbjct: 393 KTGPAVA------------------KAQAGKREEDS---QSSSEESDSEEEAPAQAKPSG 431

Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPG 220
           +A               V+ ++A    +P  GA    P  ++  P  A  +  +QE    
Sbjct: 432 KA-------------PQVRAASAPAKESPRKGAAPAPP--RKTGPAAAQVQVGKQE---- 472

Query: 221 GAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG---- 276
                     S ++E D+ R+A  A    + + LG      PA+   +   G  AG    
Sbjct: 473 ------EDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPP 526

Query: 277 ---------------------RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVK 315
                                    ++D+ + ++   VA A   S  N  +A     P K
Sbjct: 527 GKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAK 586

Query: 316 --PIKAKP------QYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEP 367
             P KA P        KP D+    E S  +    EA    TA  +     +I    + P
Sbjct: 587 GPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTA-AQAKPALKIPQTKACP 645

Query: 368 FK----EPPKVEKPSVQSSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDD 423
            K       KV    V +  P+K   +  P   A    AV+G    ++ AE  S+++  D
Sbjct: 646 KKTNTTASAKVAPVRVGTQAPRKAGTATSP---AGSSPAVAG--GTQRPAEDSSSSEESD 700

Query: 424 KEQSK 428
            E+ K
Sbjct: 701 SEEEK 705


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 100/457 (21%), Positives = 169/457 (36%), Gaps = 64/457 (14%)

Query: 34  SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93
           S A E   +PP+   P+++   A +P   ++      PA+ E  + A A  P    +  +
Sbjct: 552 SPAKEEAKSPPEAKSPEKEE--AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609

Query: 94  EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD----AP 149
           E A  P  +       + S +        +     + + PE +  P  E   S     +P
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669

Query: 150 FERETQYQKDFRAWPLPRRGDHPWIPK-PVQISAASQASAPILGAPKRRPQSQERWPVQA 208
            + E +  +  ++ P+      P   K PV+  A S   A      + +   + + PV+ 
Sbjct: 670 VKAEAKSPEKAKS-PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 209 AAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPA----- 263
            A+  E+  +P      +  KA   ++  T     P      A+    E+   PA     
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP-----EAKTPAKEEARSPADKFPE 783

Query: 264 ---AQAQVQATGPEAGRGRAAADAL--NRQI--REEVASAVSSSYRNEFRAWTDIKPVKP 316
              +  + +   PE  +     DA    ++I  +EEV S V    + +     ++K  +P
Sbjct: 784 KAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ-----EVKVKEP 838

Query: 317 IKAKPQYKPPDDKMVHETSYSAQF---KGEASKPTTADNKVIDRRRIRSLYSEPFKEP-- 371
            K   + K P      E   S +    K EA KP   + K     + +    E  KE   
Sbjct: 839 PKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAE 898

Query: 372 -------PKVEKPSV----QSSKPK-KTSASHK---------PTRKAKDKQAV-----SG 405
                  P+ E P+     + +KPK KT  + K         P++ A+ K+A      + 
Sbjct: 899 DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTK 958

Query: 406 QAAKKKSAEGPST---TKPDDKEQSKEMNNKLAEAKE 439
           +   KK  E P T    K DDK  SKE +   AE  E
Sbjct: 959 EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAE 995



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 59/268 (22%), Positives = 109/268 (40%), Gaps = 25/268 (9%)

Query: 177 PVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAAPGGAGGLAAGKASGADER 236
           PV+  A S A A      + +  ++ + P +A + A+E+  +P  A          + E+
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA---------KSPEK 569

Query: 237 DTRRKAGPAWIVRRAEGLGHEQTPLPA-AQAQVQATGPEAGRGRAAADALNRQIREEVAS 295
           +  +         +A+    E+   PA A++  +A  P     ++ A+A    ++EE  S
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA-KSPVKEEAKS 628

Query: 296 AVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHETSYSAQFKGEASKPTTADNKV- 354
                   + ++ T  +   P KAK    P  ++        +  K EA  P  A + V 
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAK---SPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685

Query: 355 ---IDRRRIRSLYSEPFKEPPKVEKPSVQSSK-PKKTSASHKPTRKAKDKQAVSGQAAKK 410
                  + +S   E  K P K + P  + +K P+K  +  K   K  +K     ++  K
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK----AKSPVK 741

Query: 411 KSAEGPSTTKPDDKEQSKEMNNKLAEAK 438
           + A+ P   K    E++K ++ K  EAK
Sbjct: 742 EEAKSPEKAK--SPEKAKTLDVKSPEAK 767



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 83/418 (19%), Positives = 152/418 (36%), Gaps = 78/418 (18%)

Query: 47   PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE------------RE 94
            P  ++   P  A    +A A   + A+  + A A++   A  P  E            +E
Sbjct: 655  PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714

Query: 95   PAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRA-WKVQRPEPSCRPRSEYQPSDAPFERE 153
             A  P ++   P      T   A S ++++ ++  K + PE +     +   +  P + E
Sbjct: 715  EAKSPEKA-KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773

Query: 154  TQYQKDFRAWPLPRRGDHPW-----IPKPVQISAASQASAPILGAPKRR----PQSQERW 204
             +   D      P +   P       P+  +      A AP    PK+     P  +E  
Sbjct: 774  ARSPAD----KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829

Query: 205  P----VQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260
            P    V+   +  E+E AP      A  K    +++D++++  P            ++ P
Sbjct: 830  PQEVKVKEPPKKAEEEKAP------ATPKTE--EKKDSKKEEAPK-----------KEAP 870

Query: 261  LPAAQAQVQATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAK 320
             P  + + +    +    +  A     + +++V +    +   +     D KP +  K +
Sbjct: 871  KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA-KVEVKEDAKPKE--KTE 927

Query: 321  PQYKPPDDKMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQ 380
               K PDD    E S  A+ K  A  P   D K    ++         +E PK E  + +
Sbjct: 928  VAKKEPDDAKAKEPSKPAEKKEAA--PEKKDTKEEKAKKP--------EEKPKTEAKAKE 977

Query: 381  SSKPKKTSASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAK 438
              K    + S +P++   +K       A+K S    ST + D K   K   +K A+ K
Sbjct: 978  DDK----TLSKEPSKPKAEK-------AEKSS----STDQKDSKPPEKATEDKAAKGK 1020


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 32/120 (26%), Positives = 46/120 (38%), Gaps = 3/120 (2%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G PP PPPP   A P    P+    A    PA+ E + +  A GP P P     P  GP 
Sbjct: 794 GLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPV 853

Query: 101 RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
              P   +  G+  G     + +D     +     S     E +  +   E E + ++DF
Sbjct: 854 TLPPPQLVPEGTPGGGGPPALEEDLTVINI---NSSDEEEEEEEEEEEEEEEEEEEEEDF 910



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 24/79 (30%), Positives = 33/79 (41%), Gaps = 19/79 (24%)

Query: 40   PGAPPQPPPPQQQAQPALAP-----------------PSARAVAIETQPAQGEL--DAVA 80
            P  PP   PP+ Q +P   P                  +A  +A E  P+QGE+  +  +
Sbjct: 984  PALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGES 1043

Query: 81   RATGPAPGPTGEREPAAGP 99
             A GP P    E EP+A P
Sbjct: 1044 PAAGPPPQELVEEEPSAPP 1062



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 23/74 (31%), Positives = 27/74 (36%), Gaps = 3/74 (4%)

Query: 36  ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQP--AQGELDAVARATGPAPGPTGER 93
           A  HP  PP  P       PA  PP          P    G + +V       P P+   
Sbjct: 629 ALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGP 688

Query: 94  EPAAGPGRSG-PGP 106
            P+AGP  S  PGP
Sbjct: 689 MPSAGPVPSARPGP 702


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 62/257 (24%), Positives = 85/257 (33%), Gaps = 31/257 (12%)

Query: 34  SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAPG 88
           S +   P   PQ PPPQ   QP   PP       +  P QG           +  GP P 
Sbjct: 87  SRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNRPQGPPPPGKPQGPPPQ 144

Query: 89  PTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQ 144
               R P + PG+    P  G     GP     +          K Q P P  +P+    
Sbjct: 145 GDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQG--P 202

Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQS 200
           P      R +Q        P P+ G+ P  P P     Q       + P    P  +PQ 
Sbjct: 203 PPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 262

Query: 201 QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260
               P Q  ++++   + P        GK  G  +++     GP      A G   +   
Sbjct: 263 P---PAQGGSKSQSARSPP--------GKPQGPPQQEGNNPQGPP---PPAGGNPQQPQA 308

Query: 261 LPAAQAQVQATGPEAGR 277
            PA Q Q     P+ GR
Sbjct: 309 PPAGQPQGPPRPPQGGR 325



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 43/188 (22%), Positives = 63/188 (33%), Gaps = 22/188 (11%)

Query: 40  PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99
           P   PQ PPPQ   +P   PP  +    +  P QG+     ++  P   P   + P    
Sbjct: 53  PPGKPQGPPPQGGNKPQGPPPPGKP---QGPPPQGD-----KSRSPRSPPGKPQGPPPQG 104

Query: 100 GRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKD 159
           G    GP    G   GP            + Q P P  +P+    P      R  +    
Sbjct: 105 GNQPQGPPPPPGKPQGPPPQ------GGNRPQGPPPPGKPQG--PPPQGDKSRSPRSPPG 156

Query: 160 FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRR---PQSQERWPVQAAAEAREQE 216
               P P+ G+ P  P P           P  G  K +   P  + + P     ++R  +
Sbjct: 157 KPQGPPPQGGNQPQGPPP---PPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQ 213

Query: 217 AAPGGAGG 224
           + PG   G
Sbjct: 214 SPPGKPQG 221



 Score = 33.5 bits (75), Expect = 0.39
 Identities = 36/128 (28%), Positives = 46/128 (35%), Gaps = 18/128 (14%)

Query: 34  SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93
           S +++ P   PQ PPPQ   QP   PP       +  P QG      +  GP P    + 
Sbjct: 209 SRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGG----NKPQGPPPPGKPQG 262

Query: 94  EPAAG-----PGRSGPGPGLGSGSTSG-------PADSVMRQDYRAWKVQRPEPSCRPRS 141
            PA G       RS PG   G     G       P      Q  +A    +P+   RP  
Sbjct: 263 PPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQGPPRPPQ 322

Query: 142 EYQPSDAP 149
             +PS  P
Sbjct: 323 GGRPSRPP 330


>gi|116256464 hypothetical protein LOC343990 [Homo sapiens]
          Length = 962

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 102/442 (23%), Positives = 156/442 (35%), Gaps = 102/442 (23%)

Query: 43  PPQPPPPQQQAQPALAPPSARAVAIETQPAQGEL-DAVARATGPAPGPTGEREPAAGPGR 101
           PP+  P      P+      R+V  E +P    L D      GPAP P  E E     G 
Sbjct: 413 PPETDPAATSEAPSARDGPERSVPKEAEPTPPVLPDEEKGPPGPAPEPEREAETEPERGA 472

Query: 102 SGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEP-SCRPRSEYQPSDAPFERETQYQKDF 160
                 +G+  ++ PA S             P P SC        S+ P           
Sbjct: 473 GTEPERIGTEPSTAPAPS------------PPAPKSCLKHRPAAASEGPAASP------- 513

Query: 161 RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQ--ERWPVQAAAEAREQEAA 218
              PL      P  P P  + A  +A+AP       RP+++  E  P  A   A E++A 
Sbjct: 514 ---PLAAAESPPVEPGPGSLDA--EAAAP------ERPKAERAEAPPAGAERAAPERKAE 562

Query: 219 PGGAGGLAAGKASGADERDTRR-----------------KAGPAWIVRRA----EGLGHE 257
            GGA    A K S +  R   R                 ++GP W    A    +GL   
Sbjct: 563 RGGAELRGAKKFSVSSCRARPRPGVSRPLERASGRLPLARSGPVWRSEAALDDLQGLPEP 622

Query: 258 QTPLPAAQAQVQATGPEAGRGRAAADALNRQIREEVASA-------------VSSSYRNE 304
           Q   P  + ++   GP+    RAA+ A  R+  +E A+A               S  RN 
Sbjct: 623 QHAKPGPR-KLAERGPQDSGDRAASPAGPRKSPQEAAAAPGTREPCPAAQEPAPSEDRNP 681

Query: 305 F---------------RAWTDIKPVKPIKAKPQYK------PPDDKMVHET--------S 335
           F                A  ++K VK   A+ + +      P ++K    T        +
Sbjct: 682 FPVKLRSTSLSLKYRDGASQEVKGVKRYSAEVRLERSLTVLPKEEKCPLGTAPALRGTRA 741

Query: 336 YSAQFKGEASKPTTADNK-VIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHKPT 394
            S Q KG+A  P    +K  + R+ +   ++ P +  P    P  +  + +  +A  +P 
Sbjct: 742 PSDQGKGKARPPEPLSSKPPLPRKPLLQSFTLPHQPAPPDAGPGEREPRKEPRTAEKRPL 801

Query: 395 RKAKDKQ---AVSGQAAKKKSA 413
           R+  +K    A +G  A  + A
Sbjct: 802 RRGAEKSLPPAATGPGADGQPA 823


>gi|30089916 phosphofurin acidic cluster sorting protein 1 [Homo
           sapiens]
          Length = 963

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 32/99 (32%), Positives = 36/99 (36%), Gaps = 7/99 (7%)

Query: 42  APPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGR 101
           +P QPPP QQQ QP   P   +      Q         A A   +   T      A    
Sbjct: 28  SPQQPPPQQQQQQPPQQPTPPKL----AQATSSSSSTSAAAASSSSSSTSTSMAVAVASG 83

Query: 102 SGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140
           S P  G G G T  P   V    Y  W+V R   SC PR
Sbjct: 84  SAPPGGPGPGRTPAP---VQMNLYATWEVDRSSSSCVPR 119


>gi|4506321 protein tyrosine phosphatase, receptor type, N precursor
           [Homo sapiens]
          Length = 979

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 76/276 (27%), Positives = 104/276 (37%), Gaps = 45/276 (16%)

Query: 38  EHPGAPPQPPPPQQQAQPALAPP--------SARAVAIETQPAQGELDAVARATGPAPGP 89
           EH   PPQPP P    +PAL  P           +   E  P    +  + +A  PA   
Sbjct: 186 EHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPA--- 242

Query: 90  TGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQP 145
                  A  G  G  PG   G   GP+ + + QD    Y A ++  P  +  PR   Q 
Sbjct: 243 --LFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG 300

Query: 146 SDAPFERETQ-YQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERW 204
           S +  E   + Y+K+     L  RG+ P  P  VQ  AA Q  A +L       + ++  
Sbjct: 301 SSSRAEDSPEGYEKE----GLGDRGEKPASP-AVQPDAALQRLAAVLAG--YGVELRQLT 353

Query: 205 PVQAAAEAREQEAAPGGAGGLAAGKAS-GADERDTRRKAGPAWIVRRAEGLGHEQTPLPA 263
           P Q +      +  P GAG    G  + GAD + T    GP          G +   LPA
Sbjct: 354 PEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTME--GPV--------EGRDTAELPA 403

Query: 264 AQAQVQATGPEAGRGRAAADALNRQIREEVASAVSS 299
                  T P  G   A+  +   Q   +V S VSS
Sbjct: 404 ------RTSPMPGHPTASPTSSEVQ---QVPSPVSS 430


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 48/163 (29%), Positives = 54/163 (33%), Gaps = 35/163 (21%)

Query: 39  HPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAG 98
           HPG P  PPP  Q    +  PP  R    E  P QG      ++ GP P P     P + 
Sbjct: 179 HPGKPEGPPP--QGGNQSQGPPP-RPGKPEGPPPQGG----NQSQGPPPRPGKPEGPPSQ 231

Query: 99  PGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQK 158
            G    GP    G   GP            K QRP P  RP+    P   P +       
Sbjct: 232 GGNKPQGPPPHPGKPQGPPPQ------EGNKPQRPPPPGRPQGPPPPGGNPQQ------- 278

Query: 159 DFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQ 201
                PLP     P  P P           P  G P R PQ Q
Sbjct: 279 -----PLPPPAGKPQGPPP----------PPQGGRPHRPPQGQ 306



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 69/256 (26%), Positives = 83/256 (32%), Gaps = 44/256 (17%)

Query: 41  GAPPQP-----PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREP 95
           G PP+P     PPPQ   Q    PP  R    E QP QG      ++ GP P P     P
Sbjct: 70  GPPPRPGKPEGPPPQGGNQSQGPPP--RPGKPEGQPPQGG----NQSQGPPPRPGKPEGP 123

Query: 96  AAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQ 155
               G    GP    G   GP      Q       Q P P  RP    +P   P +   Q
Sbjct: 124 PPQGGNQSQGPPPRPGKPEGPPPQGGNQS------QGPPP--RPG---KPEGPPPQGGNQ 172

Query: 156 YQKDFRAWPLPRRGDHPWIPK--PVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAR 213
            Q      P P    HP  P+  P Q    SQ   P  G P+  P               
Sbjct: 173 SQ-----GPPP----HPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPG 223

Query: 214 EQEAAPGGAGGLA------AGKASGADERDTRRKAGPAWIVRRAEGL----GHEQTPLPA 263
           + E  P   G          GK  G   ++  +   P     R +G     G+ Q PLP 
Sbjct: 224 KPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGNKPQRPP-PPGRPQGPPPPGGNPQQPLPP 282

Query: 264 AQAQVQATGPEAGRGR 279
              + Q   P    GR
Sbjct: 283 PAGKPQGPPPPPQGGR 298


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 59/236 (25%), Positives = 82/236 (34%), Gaps = 29/236 (12%)

Query: 43   PPQPPPPQQQAQPA--LAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
            P  P P +  AQP     PP  R VA  T+PA  +           P P+G  +P+   G
Sbjct: 1085 PATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQ---------RPPPPSGRSQPSPQAG 1135

Query: 101  RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRS-EYQPSDAPFERETQYQKD 159
             +GPGP     ST+ P         RA  +  P+   R  +    P       ET     
Sbjct: 1136 LAGPGP--AGYSTARPTIPP-----RAGVISAPQSHARASAGRLTPESQSKTSETSKGST 1188

Query: 160  FRAWPL-PRRGDHPWIPKPVQISAASQASAPILG-APKRRPQSQERWPVQAAAEAREQEA 217
            F   PL P+    P    P       +   P+    P+  PQ     P Q    +R   +
Sbjct: 1189 FLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHS 1248

Query: 218  APGGAGGLAAGKASGADE--RDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQAT 271
             P  A      K +G  +  R++  K  P       E L      +  AQ  VQ +
Sbjct: 1249 LPSEASSQPQVKTNGISDGKRESPLKIDP------FEDLSFNLLAVSKAQLSVQTS 1298



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 38/167 (22%), Positives = 61/167 (36%), Gaps = 30/167 (17%)

Query: 40   PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99
            P  P +PPPP  ++QP+              P  G         GP P       P   P
Sbjct: 1115 PAPPQRPPPPSGRSQPS--------------PQAG-------LAGPGPAGYSTARPTI-P 1152

Query: 100  GRSG--PGPGLGSGSTSG---PADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA--PFER 152
             R+G    P   + +++G   P       +        PEP  +P++ + P  +  P  +
Sbjct: 1153 PRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEP-LKPQAAFPPQSSLPPPAQ 1211

Query: 153  ETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQ 199
              Q      A P+P+ G  P +  P Q    S++S  +      +PQ
Sbjct: 1212 RLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1258


>gi|153791535 general control of amino acid synthesis 5-like 2 [Homo
           sapiens]
          Length = 837

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 32/86 (37%), Positives = 35/86 (40%), Gaps = 3/86 (3%)

Query: 43  PPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRS 102
           P Q P P   AQP   P  + A A    PA     A      PAP P     PA   G  
Sbjct: 4   PSQAPTPAPAAQPR--PLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGTG 61

Query: 103 GPGPGL-GSGSTSGPADSVMRQDYRA 127
           GPG G  G+GS   PA   + Q  RA
Sbjct: 62  GPGVGSGGAGSGGDPARPGLSQQQRA 87



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 5/99 (5%)

Query: 37  TEHPGAPPQP---PPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93
           T  P A P+P   P P     PA +P SA        PA     A A +TG   G  G  
Sbjct: 9   TPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT--GGPGVG 66

Query: 94  EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQR 132
              AG G     PGL     +    + +R   RA K+++
Sbjct: 67  SGGAGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEK 105


>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
          Length = 2303

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 78/313 (24%), Positives = 118/313 (37%), Gaps = 46/313 (14%)

Query: 31   TKYSEATEHPGAPPQPPPPQQQ--AQPALAPPSARAVAIETQPAQGELDAVARATGPAPG 88
            T+ + A   PGA P P  P +   A+      S   +    +PA+     +ARA  P PG
Sbjct: 1894 TQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAV-PEPG 1952

Query: 89   PTGEREPAAGPGRSGPGPG-------LGSGSTSGPADSVMRQ-----DYRAWKVQRPEPS 136
            P G     AGPG  G   G       L SGS S       RQ     +    + +R E S
Sbjct: 1953 PRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELS 2012

Query: 137  CRPRSEYQPSDAP--------------FERETQYQKDFRAWPLPRRGDHPWI-----PKP 177
                +   P  A                 R  + +   R  P P R   P        +P
Sbjct: 2013 SAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERP 2072

Query: 178  VQISAASQASAPILGAPKRRPQSQERW---PVQAAAEAREQEAAPGGAGGLAAGKASGAD 234
             + + +   S   + AP  RP++ +R+   P  + A   +       A   AA ++S  +
Sbjct: 2073 ARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGE 2132

Query: 235  ERDTRRKAGP--AWIVRRAEGLGH-EQTPLPAAQAQVQATGPEAGRG----RAAADALNR 287
             R   R A P   W   R E + H  ++ LPA    ++ + PE        R  +DA+ +
Sbjct: 2133 PRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQ 2192

Query: 288  QIREEVASAVSSS 300
               EEVA+  ++S
Sbjct: 2193 --TEEVAAPKTNS 2203



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 66/266 (24%), Positives = 94/266 (35%), Gaps = 33/266 (12%)

Query: 25   AVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARA----VAIETQPAQGELDAVA 80
            A+P  FT+     E P    + P P + A PA APP AR     +A ET P      + +
Sbjct: 1532 AIPRAFTR-----ERPQGRKEAPAPSKAA-PA-APPPARTQPSLIADETPPCYSLSSSAS 1584

Query: 81   RATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPR 140
              + P P       P          PG G G  S P+     +      +QR   S  PR
Sbjct: 1585 SLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEE-----LLQRCISSALPR 1639

Query: 141  SEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQS 200
                 S     +    + D R    P  G      +      AS   +    A +    S
Sbjct: 1640 RRPPVSGLRRRKPRATRLDER----PAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANS 1695

Query: 201  QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEG-LGHEQT 259
               W  QAAA  RE  +         +G + G+  +  + + G     R+AEG +G  + 
Sbjct: 1696 IVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKG-----RQAEGEMGSARR 1750

Query: 260  PLPAAQAQVQAT-------GPEAGRG 278
            P     A V+ +       GPE  RG
Sbjct: 1751 PEKRGAASVKTSGSPRSPAGPEKPRG 1776



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 71/323 (21%), Positives = 110/323 (34%), Gaps = 48/323 (14%)

Query: 41   GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
            G P     P++ A P LA P+A A      P Q    ++ R     P  T E    + P 
Sbjct: 1807 GTPGPRATPRKVAPPCLAQPAAPAKV--PSPGQQRSRSLHR-----PAKTSELATLSQPP 1859

Query: 101  RSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF 160
            RS   P   + + S  +              +P P  RP         P  +        
Sbjct: 1860 RSATPPARLAKTPSSSSSQTS-------PASQPLPRKRP---------PVTQAAGALPGP 1903

Query: 161  RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRR--PQSQERWPVQAAAEAREQEAA 218
             A P+P+      + K  + +  S    P +  P RR  P      P          EA 
Sbjct: 1904 GASPVPKTPARTLLAKQHK-TQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAG 1962

Query: 219  PGGAGG------LAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQA-T 271
            PG  GG      +A+  +SG++  D          ++ + GL   ++ L +A++   A  
Sbjct: 1963 PGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQ 2022

Query: 272  GPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKP-----P 326
            G    RGR A  A+           + SS   E RA     P    +  P  +P     P
Sbjct: 2023 GASPRRGRPALPAV----------FLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERP 2072

Query: 327  DDKMVHETSYSAQFKGEASKPTT 349
              +   E+      +  A++P T
Sbjct: 2073 ARRTTSESPSRLPVRAPAARPET 2095



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 28/75 (37%), Positives = 33/75 (44%), Gaps = 13/75 (17%)

Query: 25   AVPLVFTKYSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATG 84
            A+P VF   S   E   AP Q P P +Q      PP+AR       P+ GE  A  R T 
Sbjct: 2032 ALPAVFLCSSRCEELRAAPRQGPAPARQ-----RPPAAR-------PSPGERPA-RRTTS 2078

Query: 85   PAPGPTGEREPAAGP 99
             +P     R PAA P
Sbjct: 2079 ESPSRLPVRAPAARP 2093


>gi|73476377 LBXCOR1 homolog [Homo sapiens]
          Length = 921

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 55/206 (26%), Positives = 80/206 (38%), Gaps = 35/206 (16%)

Query: 35  EATEHPGAPPQPPPPQQQAQPALAPPSARAVAIET-QPAQGELDAVARATGPAPGPTGER 93
           EA   P AP  PPPP         PP+ +   +   +P   + +++A+  G A    G  
Sbjct: 525 EALPPPLAPLPPPPP---------PPARKGSYVSAFRPVVKDTESIAKLYGSAREAYG-- 573

Query: 94  EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRP------EPSCRPRSEYQPSD 147
              AGP R GPGPG GSG    P    + +   ++    P      EP     S   P D
Sbjct: 574 ---AGPAR-GPGPGAGSGGYVSP--DFLSEGSSSYNSASPDVDTADEPEVDVESNRFPDD 627

Query: 148 APFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAA-SQASAPILGAPKRR------PQS 200
              + ET+             G+ P  P     S A   A++P  G+P+ R      P  
Sbjct: 628 EDAQEETEPSAPSAGG--GPDGEQPTGPPSATSSGADGPANSPDGGSPRPRRRLGPPPAG 685

Query: 201 QERWPVQAAAE--AREQEAAPGGAGG 224
           +  +   AA +   R + + P G GG
Sbjct: 686 RPAFGDLAAEDLVRRPERSPPSGGGG 711


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 36/122 (29%), Positives = 41/122 (33%), Gaps = 22/122 (18%)

Query: 38  EHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER---- 93
           E P   P+PPPP     P  APP A  +  E  P          A GP P  T E     
Sbjct: 18  EQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATEL 77

Query: 94  ------EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSD 147
                 EPA  P  S P P   +     PA               PEP+  P +E  P  
Sbjct: 78  YTEPTPEPATEPA-SEPAPEPATEPAPEPATE-----------PAPEPAPEPATESAPEP 125

Query: 148 AP 149
            P
Sbjct: 126 TP 127



 Score = 28.9 bits (63), Expect = 9.7
 Identities = 32/118 (27%), Positives = 38/118 (32%), Gaps = 17/118 (14%)

Query: 33  YSEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92
           Y+E T  P   P   P  +   PA  P  A   A E  P      A   A  P P P  E
Sbjct: 78  YTEPTPEPATEPASEPAPE---PATEP--APEPATEPAPEPAPEPATESAPEPTPEPALE 132

Query: 93  REPAAGPGRSGP-GPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAP 149
             P   P  +    P L    T  P   +            PE       E++PS AP
Sbjct: 133 SVPEPAPELTPEVAPELAPEPTPEPVTEL-----------APEFCPEAAPEFRPSPAP 179



 Score = 28.9 bits (63), Expect = 9.7
 Identities = 32/113 (28%), Positives = 41/113 (36%), Gaps = 17/113 (15%)

Query: 54  QPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGST 113
           +PA  P S  A    T+PA         AT PAP P  E    + P    P P     S 
Sbjct: 84  EPATEPASEPAPEPATEPAP------EPATEPAPEPAPEPATESAP---EPTPEPALESV 134

Query: 114 SGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLP 166
             PA  +  +         PEP+  P +E  P   P     +   +FR  P P
Sbjct: 135 PEPAPELTPE---VAPELAPEPTPEPVTELAPEFCP-----EAAPEFRPSPAP 179


>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
          Length = 1120

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 66/258 (25%), Positives = 96/258 (37%), Gaps = 40/258 (15%)

Query: 44   PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSG 103
            P PPPP++ +  +++ PS     ++  P            GP  G TG R        +G
Sbjct: 786  PPPPPPKRLS--SVSGPSPEPPPLDESP------------GPKEGATGPRRRTLSE-PAG 830

Query: 104  PGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA-PFERE---TQYQKD 159
            P    G  + +GPA     ++        P P   P S     +  PF  E   T  Q+ 
Sbjct: 831  PSEPPGPPAPAGPASDTEEEE--------PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRP 882

Query: 160  FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEA-REQEAA 218
              A P PR       P P  +      S  +    KRRP+ +ER P+Q A  A     A 
Sbjct: 883  KPAGPPPRE-----TPVPPGLDFNLTESDTV----KRRPKCREREPLQTALLAFGVASAT 933

Query: 219  PGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRG 278
            PG A  L +     +    +  +  P+ +   A+G+     P PA Q  V    P  G  
Sbjct: 934  PGPAAPLPSPTPGESPPASSLPQPEPSSL--PAQGVPTPLAPSPAMQPPVPPC-PGPGLE 990

Query: 279  RAAADALNRQIREEVASA 296
             +AA   N +     A A
Sbjct: 991  SSAASRWNGETEPPAAPA 1008



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 61/251 (24%), Positives = 83/251 (33%), Gaps = 48/251 (19%)

Query: 36  ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV---------ARATGPA 86
           A +  G  P PP  +   +    PP        + P QG    V         + A GP 
Sbjct: 634 APQPSGGDPSPPQERNLPEGTERPPKL----CSSLPGQGPPPYVFMYPQGSPSSPAPGPP 689

Query: 87  PGPTGEREPAAGPGRSGPGP-----------------GLGSGSTSGPADSVMRQDYRAWK 129
           PG        AGP  + P P                 G   G   GP  S +     A  
Sbjct: 690 PGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGS--YATL 747

Query: 130 VQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAP 189
            +RP  S   R+    +  P  R T   + F A    R+G  P  P P ++S+ S  S  
Sbjct: 748 TRRPGRSALVRTSPSVTPTP-ARGTPRSQSF-ALRARRKGPPP--PPPKRLSSVSGPS-- 801

Query: 190 ILGAPKRRPQSQERWPVQAAAEAR----EQEAAPGGAGG--LAAGKASGADERDTRRKAG 243
               P+  P  +   P + A   R     + A P    G    AG AS  +E +   +  
Sbjct: 802 ----PEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGT 857

Query: 244 PAWIVRRAEGL 254
           P       EGL
Sbjct: 858 PPSRGSSGEGL 868



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 34   SEATEHPGAP-PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92
            + AT  P AP P P P +     +L  P   ++     PAQG    V     P+P     
Sbjct: 930  ASATPGPAAPLPSPTPGESPPASSLPQPEPSSL-----PAQG----VPTPLAPSPAMQPP 980

Query: 93   REPAAGPGRSGPGPGLGSGSTSGPA 117
              P  GPG         +G T  PA
Sbjct: 981  VPPCPGPGLESSAASRWNGETEPPA 1005


>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
          Length = 1202

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 66/258 (25%), Positives = 96/258 (37%), Gaps = 40/258 (15%)

Query: 44   PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSG 103
            P PPPP++ +  +++ PS     ++  P            GP  G TG R        +G
Sbjct: 868  PPPPPPKRLS--SVSGPSPEPPPLDESP------------GPKEGATGPRRRTLSE-PAG 912

Query: 104  PGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA-PFERE---TQYQKD 159
            P    G  + +GPA     ++        P P   P S     +  PF  E   T  Q+ 
Sbjct: 913  PSEPPGPPAPAGPASDTEEEE--------PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRP 964

Query: 160  FRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEA-REQEAA 218
              A P PR       P P  +      S  +    KRRP+ +ER P+Q A  A     A 
Sbjct: 965  KPAGPPPRE-----TPVPPGLDFNLTESDTV----KRRPKCREREPLQTALLAFGVASAT 1015

Query: 219  PGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAGRG 278
            PG A  L +     +    +  +  P+ +   A+G+     P PA Q  V    P  G  
Sbjct: 1016 PGPAAPLPSPTPGESPPASSLPQPEPSSL--PAQGVPTPLAPSPAMQPPVPPC-PGPGLE 1072

Query: 279  RAAADALNRQIREEVASA 296
             +AA   N +     A A
Sbjct: 1073 SSAASRWNGETEPPAAPA 1090



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 61/251 (24%), Positives = 83/251 (33%), Gaps = 48/251 (19%)

Query: 36  ATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAV---------ARATGPA 86
           A +  G  P PP  +   +    PP        + P QG    V         + A GP 
Sbjct: 716 APQPSGGDPSPPQERNLPEGTERPPKL----CSSLPGQGPPPYVFMYPQGSPSSPAPGPP 771

Query: 87  PGPTGEREPAAGPGRSGPGP-----------------GLGSGSTSGPADSVMRQDYRAWK 129
           PG        AGP  + P P                 G   G   GP  S +     A  
Sbjct: 772 PGAPWAFSYLAGPPATPPDPPRPKRRSHSLSRPGPTEGDAEGEAEGPVGSTLGS--YATL 829

Query: 130 VQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQISAASQASAP 189
            +RP  S   R+    +  P  R T   + F A    R+G  P  P P ++S+ S  S  
Sbjct: 830 TRRPGRSALVRTSPSVTPTP-ARGTPRSQSF-ALRARRKGPPP--PPPKRLSSVSGPS-- 883

Query: 190 ILGAPKRRPQSQERWPVQAAAEAR----EQEAAPGGAGG--LAAGKASGADERDTRRKAG 243
               P+  P  +   P + A   R     + A P    G    AG AS  +E +   +  
Sbjct: 884 ----PEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEEPGPEGT 939

Query: 244 PAWIVRRAEGL 254
           P       EGL
Sbjct: 940 PPSRGSSGEGL 950



 Score = 32.7 bits (73), Expect = 0.67
 Identities = 25/85 (29%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 34   SEATEHPGAP-PQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGE 92
            + AT  P AP P P P +     +L  P   ++     PAQG    V     P+P     
Sbjct: 1012 ASATPGPAAPLPSPTPGESPPASSLPQPEPSSL-----PAQG----VPTPLAPSPAMQPP 1062

Query: 93   REPAAGPGRSGPGPGLGSGSTSGPA 117
              P  GPG         +G T  PA
Sbjct: 1063 VPPCPGPGLESSAASRWNGETEPPA 1087


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 61/257 (23%), Positives = 84/257 (32%), Gaps = 29/257 (11%)

Query: 34  SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER 93
           S ++  P   PQ PPPQ   QP   PP          P  G         G   GP  + 
Sbjct: 170 SRSSRSPPGKPQGPPPQGGNQPQ-GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG 228

Query: 94  EPAAGPGRSGPG-----PGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQ 144
           +  +   RS PG     P  G     GP     +          K Q P P  +P+    
Sbjct: 229 DNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-P 287

Query: 145 PSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQS 200
           P      R ++        P P+ G+ P  P P     Q       + P    P  +PQ 
Sbjct: 288 PQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 347

Query: 201 QERWPVQAAAEAREQEAAPGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTP 260
               P Q  +++R   + P        GK  G  +++     GP      A G   +   
Sbjct: 348 P---PPQGGSKSRSARSPP--------GKPQGPPQQEGNNPQGPP---PPAGGNPQQPQA 393

Query: 261 LPAAQAQVQATGPEAGR 277
            PA Q Q     P+ GR
Sbjct: 394 PPAGQPQGPPRPPQGGR 410



 Score = 36.6 bits (83), Expect = 0.046
 Identities = 48/198 (24%), Positives = 65/198 (32%), Gaps = 19/198 (9%)

Query: 40  PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAPGPTGERE 94
           P   PQ PPPQ   QP   PP       +  P QG           +  GP P     R 
Sbjct: 53  PPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS 110

Query: 95  PAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEYQPSDAPF 150
           P + PG+    P  G     GP     +          K Q P P  +P+    P     
Sbjct: 111 PRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP-PPQGDNK 169

Query: 151 ERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQSQERWPV 206
            R ++        P P+ G+ P  P P     Q       + P    P  +PQ     P 
Sbjct: 170 SRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP---PP 226

Query: 207 QAAAEAREQEAAPGGAGG 224
           Q   +++   + PG   G
Sbjct: 227 QGDNKSQSARSPPGKPQG 244



 Score = 35.8 bits (81), Expect = 0.079
 Identities = 49/205 (23%), Positives = 67/205 (32%), Gaps = 20/205 (9%)

Query: 34  SEATEHPGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQG-----ELDAVARATGPAP- 87
           S +   P   PQ PPPQ   QP   PP       +  P QG           +  GP P 
Sbjct: 108 SRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGPPPPGKPQGPPPQ 165

Query: 88  GPTGEREPAAGPGRSGPGPGLGSGSTSGPADSVMRQD----YRAWKVQRPEPSCRPRSEY 143
           G    R   + PG+    P  G     GP     +          K Q P P  +P+   
Sbjct: 166 GDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP- 224

Query: 144 QPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKP----VQISAASQASAPILGAPKRRPQ 199
            P      +  +        P P+ G+ P  P P     Q       + P    P  +PQ
Sbjct: 225 PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ 284

Query: 200 SQERWPVQAAAEAREQEAAPGGAGG 224
                P Q  +++R   + PG   G
Sbjct: 285 GP---PPQGGSKSRSSRSPPGKPQG 306


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 96/401 (23%), Positives = 146/401 (36%), Gaps = 86/401 (21%)

Query: 61   SARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRSGPGPGLGSGSTSGPADSV 120
            S+   A++  P  G  D  +   GP   P      AA PG   P PGL S +++G  +  
Sbjct: 1399 SSAISALDDPPLAGPKDT-STPDGPPLAPA-----AAVPGPP-PLPGLPSANSNGTPEPP 1451

Query: 121  MRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDFRAWPLPRRGDHPWIPKPVQI 180
            + ++        P P+  P+ +  P   P +          A P P     P +P P   
Sbjct: 1452 LLEEKPP---PTPPPAPTPQPQPPPPPPPPQPALPSPPPLVA-PTPSSPPPPPLPPPPPP 1507

Query: 181  SAASQ------ASAPILGAPKR----RPQSQERWPVQAAAEAREQE-AAPGGAGGLAAGK 229
            +  S       A+AP+   P+      P+  E    +    A++QE AA  G     AG+
Sbjct: 1508 AMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGE 1567

Query: 230  ASGAD---ERD-----------------TRRKAGPAWIVRRAEGLGHEQTP-LPAAQAQV 268
            + G     ERD                 T R+  P W V++A  L  + TP +   Q Q 
Sbjct: 1568 SGGEGIFRERDEFVIRAEDIPSLKLALQTGREPPPIWRVQKA--LLQKFTPEIKDGQRQF 1625

Query: 269  QATGPEAGRGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDD 328
             AT    G      DA NR  R  V    + + ++  R             KP ++PP  
Sbjct: 1626 CATSNYLGY---FGDAKNRYQRLYVKFLENVNKKDYVRVCA---------RKPWHRPP-- 1671

Query: 329  KMVHETSYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTS 388
                      +  G+A  P +A              S P   PPK   P  +   P+KT+
Sbjct: 1672 -------VPVRRSGQAKNPVSAGGS-----------SAP---PPKAPAPPPKPETPEKTT 1710

Query: 389  ASHKPTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKE 429
            +   P      +Q       +  + E PS  +P +KE+ KE
Sbjct: 1711 SEKPP------EQTPETAMPEPPAPEKPSLLRPVEKEKEKE 1745



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 22/65 (33%), Positives = 25/65 (38%), Gaps = 2/65 (3%)

Query: 40   PGAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGP 99
            P   PQPPPP    QPAL  P        + P    L        P+P P     PAA P
Sbjct: 1465 PTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPP--PPPPAAAP 1522

Query: 100  GRSGP 104
              + P
Sbjct: 1523 LAAPP 1527



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 29/90 (32%), Positives = 35/90 (38%), Gaps = 14/90 (15%)

Query: 34  SEATEHPGAPPQPP--PPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTG 91
           S+A  + G PPQPP  PP         P  A   +      QG+L  V     P P    
Sbjct: 470 SKAPSYSGGPPQPPSGPPP--------PGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHS 521

Query: 92  EREPAAGPGRS---GPGPGL-GSGSTSGPA 117
           +  P A P  S   G  P L G G   GP+
Sbjct: 522 QGLPTASPSLSYSTGHSPALSGHGGGWGPS 551



 Score = 33.9 bits (76), Expect = 0.30
 Identities = 28/94 (29%), Positives = 38/94 (40%), Gaps = 25/94 (26%)

Query: 41  GAPPQPPPPQQ----------------QAQPALAPPSARAVAIETQPAQGELDAVARATG 84
           GA P PPPP++                 AQP   PP A A+        G   ++     
Sbjct: 270 GAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQ-HYLSCGGSYPSMGHRAN 328

Query: 85  PAPGPTGEREPAAG---PGRSGPGPGLGSGSTSG 115
            A  P G  EP+ G   P ++GP     SG+T+G
Sbjct: 329 LACSPLGGGEPSPGAGEPSKAGP-----SGATAG 357



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 24/79 (30%), Positives = 29/79 (36%), Gaps = 5/79 (6%)

Query: 41  GAPPQPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPG 100
           G   +PPPP+  A P        A A  T  A G   A  +A  P     G+ +   GP 
Sbjct: 401 GGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSP-----GQPQGLLGPQ 455

Query: 101 RSGPGPGLGSGSTSGPADS 119
             G G G G       A S
Sbjct: 456 AYGQGFGGGQAQDLSKAPS 474



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 27/117 (23%), Positives = 36/117 (30%), Gaps = 10/117 (8%)

Query: 42  APPQPPPPQQQAQPA----LAPPSARAVAIETQPAQGELDAVARATGPAPGPTGER---- 93
           +PP PPP  Q  QP     L       + +   P   +L     +  P+P P+  +    
Sbjct: 763 SPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVH 822

Query: 94  --EPAAGPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDA 148
             EPA   G   P P         P            +   P P  RP     P  A
Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGA 879



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 24/84 (28%), Positives = 30/84 (35%), Gaps = 12/84 (14%)

Query: 24  IAVPLVFTKYSEATEHPGAPPQPPPPQQQAQ-----------PALAPPSAR-AVAIETQP 71
           + V L+     +    P  PP PPPP    Q           PA   P  R   +++   
Sbjct: 819 VGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPG 878

Query: 72  AQGELDAVARATGPAPGPTGEREP 95
           A  EL        PAPG TG   P
Sbjct: 879 AMQELLGALEPLPPAPGDTGVGPP 902



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 65/262 (24%), Positives = 82/262 (31%), Gaps = 65/262 (24%)

Query: 40  PGAPPQPPPPQQQAQP--ALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAA 97
           PG P  PPPP+        LA  SA A A E    Q     +   +G APGP        
Sbjct: 229 PGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQ-----LYNFSGAAPGP-------- 275

Query: 98  GPGRSGPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQ 157
                             P  ++ RQD      QRP  +  P     P   P      Y 
Sbjct: 276 ----------------PPPERALPRQDTVIKHYQRPASAQPP-----PPPPPAHALQHY- 313

Query: 158 KDFRAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRP---QSQERWPVQAAAEARE 214
                  L   G +P +        A+ A +P LG  +  P   +  +  P  A A A  
Sbjct: 314 -------LSCGGSYPSMG-----HRANLACSP-LGGGEPSPGAGEPSKAGPSGATAGASG 360

Query: 215 QEAAPGGAGGLAAGKASGADE---RDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQ-- 269
           +   P  AGG  AG   G      +    K G       A G      P   A  + Q  
Sbjct: 361 RATGPEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSL 420

Query: 270 -------ATGPEAGRGRAAADA 284
                  ATG  +G G A   A
Sbjct: 421 GGPAAAYATGKASGAGGAGGQA 442



 Score = 29.6 bits (65), Expect = 5.7
 Identities = 13/32 (40%), Positives = 13/32 (40%)

Query: 40   PGAPPQPPPPQQQAQPALAPPSARAVAIETQP 71
            P  P  PPPP   A P  APP   A      P
Sbjct: 1507 PAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDP 1538


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,847,839
Number of Sequences: 37866
Number of extensions: 1328877
Number of successful extensions: 19648
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 309
Number of HSP's successfully gapped in prelim test: 1329
Number of HSP's that attempted gapping in prelim test: 11352
Number of HSP's gapped (non-prelim): 7414
length of query: 439
length of database: 18,247,518
effective HSP length: 105
effective length of query: 334
effective length of database: 14,271,588
effective search space: 4766710392
effective search space used: 4766710392
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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