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Search of human proteins with 4826673
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
(790 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 1584 0.0
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 1186 0.0
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 1173 0.0
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 986 0.0
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 953 0.0
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 953 0.0
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 926 0.0
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 923 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 922 0.0
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 915 0.0
gi|16753221 cadherin 22 precursor [Homo sapiens] 788 0.0
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 757 0.0
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 738 0.0
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 707 0.0
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 530 e-150
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 429 e-120
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 426 e-119
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 393 e-109
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 365 e-101
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 365 e-101
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 247 3e-65
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 240 4e-63
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 235 1e-61
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 231 2e-60
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 229 1e-59
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 225 1e-58
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 224 2e-58
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 217 3e-56
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 211 2e-54
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 207 3e-53
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 1584 bits (4101), Expect = 0.0
Identities = 790/790 (100%), Positives = 790/790 (100%)
Query: 1 MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF 60
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF
Sbjct: 1 MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF 60
Query: 61 FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE 120
FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE
Sbjct: 61 FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE 120
Query: 121 KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ 180
KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ
Sbjct: 121 KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ 180
Query: 181 VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD 240
VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD
Sbjct: 181 VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD 240
Query: 241 MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN 300
MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN
Sbjct: 241 MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN 300
Query: 301 AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY 360
AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY
Sbjct: 301 AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY 360
Query: 361 LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS 420
LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS
Sbjct: 361 LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS 420
Query: 421 VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD 480
VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD
Sbjct: 421 VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD 480
Query: 481 VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ 540
VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ
Sbjct: 481 VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ 540
Query: 541 DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC 600
DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC
Sbjct: 541 DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC 600
Query: 601 HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN 660
HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN
Sbjct: 601 HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN 660
Query: 661 DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRL 720
DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRL
Sbjct: 661 DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRL 720
Query: 721 KENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM 780
KENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM
Sbjct: 721 KENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM 780
Query: 781 YGGVDSDKDS 790
YGGVDSDKDS
Sbjct: 781 YGGVDSDKDS 790
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 1186 bits (3068), Expect = 0.0
Identities = 577/791 (72%), Positives = 678/791 (85%), Gaps = 4/791 (0%)
Query: 1 MRTYRYFLL-LFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQ 59
M +++ LL LFWV P+ + +RT + + + + L+R KR WMWNQ
Sbjct: 1 MTIHQFLLLFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRSDGKILHRQKRGWMWNQ 60
Query: 60 FFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDRE 119
FFLLEEYTGSDYQYVGKLHSDQD+GDGSLKYILSGDGAG LFII+E TGDI AT+R+DRE
Sbjct: 61 FFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDRE 120
Query: 120 EKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVV 179
EK Y LRAQAINRRT RPVEPESEF+IKIHDINDNEP F +E+YTA+VPEMS VGT VV
Sbjct: 121 EKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVV 180
Query: 180 QVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAK 239
QVTATDADDP+YGNSA+V+YSILQGQPYFSVE ETGII+TAL NM+RENREQYQVVIQAK
Sbjct: 181 QVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAK 240
Query: 240 DMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGE 299
DMGGQMGGLSGTTTVNITLTDVNDNPPRFPQ+T + ESSP GT IG +KA+DAD G+
Sbjct: 241 DMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGK 300
Query: 300 NAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFL 359
NAE+EY I DG+G DMFD++T+++TQEGIITVKK LD+E +++YTLKVEA N +V+PRF
Sbjct: 301 NAEVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFY 360
Query: 360 YLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKY 419
YLGPFKD+ V+I +EDVDEPPVFS+ +Y+ ++ ED ++ T IG+V A+DPD+ +P+++
Sbjct: 361 YLGPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRF 420
Query: 420 SVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVL 479
S+DRHTD+DRIFNI SGNGS++TSK LDRE WHN+TVIA EINNPK+++RV +++++L
Sbjct: 421 SLDRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRIL 480
Query: 480 DVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTI 539
DVNDNAP+FA FY+TFVCE A+ QLIQT+ AVDKDDP G +F FSL AA NFT+
Sbjct: 481 DVNDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSL---AAVNPNFTV 537
Query: 540 QDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQS 599
QDN+DNTA ILTRKNG+NRHE+STYLLPVVISDNDYP+QSSTGT+T+RVCACD GNMQS
Sbjct: 538 QDNEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQS 597
Query: 600 CHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSY 659
C AEAL+ P GLSTGAL+AILLCI+ILLV VVLFAAL+RQRKKEPLI+SKEDIRDNIVSY
Sbjct: 598 CSAEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSY 657
Query: 660 NDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQR 719
NDEGGGEEDTQAFDIGTLRNP AIE+ KLRRDI+PE LF+PRRTPTA DNTDVRDFIN+R
Sbjct: 658 NDEGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINER 717
Query: 720 LKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLAD 779
LKE+D DPTAPPYDSLATYAYEG S+A+SLSSLES TT+ DQ+YDYL +WGPRF KLA+
Sbjct: 718 LKEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAE 777
Query: 780 MYGGVDSDKDS 790
MYGG +SDKDS
Sbjct: 778 MYGGGESDKDS 788
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 1173 bits (3034), Expect = 0.0
Identities = 570/789 (72%), Positives = 673/789 (85%)
Query: 1 MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQF 60
MRTY Y L W + + L ++ + + + K+ L+ + L R+KR WMWNQF
Sbjct: 1 MRTYHYIPLFIWTYMFHTVDTILLQEKPNSYLSSKKIAGLTKDDGKMLRRTKRGWMWNQF 60
Query: 61 FLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREE 120
FLLEEYTG+D QYVGKLH+DQD+GDG+LKYIL+GDGAG LF+I+ENTGDI A K+LDREE
Sbjct: 61 FLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTGDIHAAKKLDREE 120
Query: 121 KPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ 180
K +YILRA+AI+R+TGR VEPESEFIIKIHDINDNEP FTK++YTA+VPEMS VGT V+Q
Sbjct: 121 KSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQ 180
Query: 181 VTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKD 240
VTATDADD YGNSAKVVYSILQGQPYFSV+ E+GIIKTAL +M RENREQYQVVIQAKD
Sbjct: 181 VTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKD 240
Query: 241 MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN 300
MGGQMGGLSGTTTVNITLTDVN+NPPRFPQSTYQF +PES P GT +GRIKA+D DVGEN
Sbjct: 241 MGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLGRIKANDPDVGEN 300
Query: 301 AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY 360
AE+EYSI +G+G DMFDVITD++TQEGIITVK+ LDFE + +YTL+V+ASN + +PRFL+
Sbjct: 301 AEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVDASNTHPDPRFLH 360
Query: 361 LGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYS 420
LGPFKD+A V+I VED+DEPPVF+K++Y++++ ED + + IG VTA DPDA N +KYS
Sbjct: 361 LGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAYDPDARNNLIKYS 420
Query: 421 VDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLD 480
VDRHTDMDRIF I S NGSIFT K LDRE+ WHNITV ATEINNPKQSS +P++I++LD
Sbjct: 421 VDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINNPKQSSHIPVFIRILD 480
Query: 481 VNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQ 540
+ND+APEFA +YETFVCE AK QLIQT+ +DKDDP GH+F F PE NFTI
Sbjct: 481 INDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFFFEPVPEFTLNPNFTIV 540
Query: 541 DNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSC 600
DNKDNTAGI+TRK+GY+R++MSTYLLP++I DNDYP+QSSTGT+T+RVCACD+ GNMQSC
Sbjct: 541 DNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSC 600
Query: 601 HAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYN 660
AEALI GLSTGALVAILLC++ILL+ VVLFAAL+RQRKKEPLIISK+D+RDNIV+YN
Sbjct: 601 TAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKKEPLIISKDDVRDNIVTYN 660
Query: 661 DEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRL 720
DEGGGEEDTQAFDIGTLRNPEA ED+KLRRD++PE +F RRT +N DV+DFI++RL
Sbjct: 661 DEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRL 720
Query: 721 KENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADM 780
KEND DP+APPYDSLATYAYEG S+ADSLSSLES+T D +QDYDYLSDWGPRFKKLADM
Sbjct: 721 KENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADCNQDYDYLSDWGPRFKKLADM 780
Query: 781 YGGVDSDKD 789
YGG DSD+D
Sbjct: 781 YGGDDSDRD 789
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 986 bits (2548), Expect = 0.0
Identities = 487/788 (61%), Positives = 611/788 (77%), Gaps = 3/788 (0%)
Query: 1 MRTYRYFLLLFWVGQPYPTLST--PLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWN 58
M T LL WV L+ P ++T ++ + L G ++ R KR W+WN
Sbjct: 1 MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQ-RSHFQRVKRGWVWN 59
Query: 59 QFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDR 118
QFF+LEEY GS+ QYVGKLHSD D+G+G++KY LSGDGAG +F I+E TGDI A + LDR
Sbjct: 60 QFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDR 119
Query: 119 EEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFV 178
EEKP Y LRAQA++ T +P+EPESEFIIK+ DINDNEP F Y ATVPEMS VG +V
Sbjct: 120 EEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYV 179
Query: 179 VQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQA 238
+QV ATDADDPTYGNSA+VVYSILQGQPYFS++ +TG+I+TAL NMDRE +EQYQV+IQA
Sbjct: 180 LQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQA 239
Query: 239 KDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVG 298
KDMGGQ+GGL+GTT VNITLTDVNDNPPRFP+S + K PESSP G+ IGRI+A D D G
Sbjct: 240 KDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFG 299
Query: 299 ENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRF 358
+NAEIEY+I G+G ++FD++TD++TQEG+I +KK LDFE KK YT KVEASN +++ RF
Sbjct: 300 QNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRF 359
Query: 359 LYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVK 418
GPFKD+ATV+I V DVDEPPVFSK Y +++ ED + T IG+VTAQD D + V+
Sbjct: 360 HSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVR 419
Query: 419 YSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKV 478
Y +D +D D F ID G+I T++LLDRE+ +N ++IA++++NP +S+V + I V
Sbjct: 420 YFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINV 479
Query: 479 LDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFT 538
LDVN+ PE + YET VCE AK Q+IQ + A D+D +G QFSF L+PEAA NFT
Sbjct: 480 LDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFT 539
Query: 539 IQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQ 598
++D ++NTAGI TR+NGY+R + Y LPVVI D+ YPVQSST T+T+RVC CD G +
Sbjct: 540 VRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTIL 599
Query: 599 SCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVS 658
SC+ EA+ P GLSTGAL+AILLCIVILL VVL+ ALRRQ+KK+ L+ SKEDIRDN++
Sbjct: 600 SCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIH 659
Query: 659 YNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQ 718
Y+DEGGGEEDTQAFDIG LRNP+ IE+NK+RRDI P++L LPR+ P DNTD+RDFI+Q
Sbjct: 660 YDDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQ 719
Query: 719 RLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLA 778
RL+END DPTAPPYDSLATYAYEG+GSVA+SLSS++S+TT+ADQDYDYL+DWGPRFK LA
Sbjct: 720 RLQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLA 779
Query: 779 DMYGGVDS 786
DM+G +S
Sbjct: 780 DMFGEEES 787
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 953 bits (2463), Expect = 0.0
Identities = 471/736 (63%), Positives = 578/736 (78%), Gaps = 3/736 (0%)
Query: 49 NRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTG 108
+R+KRSW+WNQFF+LEEY GSD YVGKLHSD D+GDGS+KYILSG+GA +FII+ENTG
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
Query: 109 DIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATV 168
DI ATKRLDREE+ Y LRAQA++R T +PVEPESEF+IKI DINDNEP F YTA V
Sbjct: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
Query: 169 PEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDREN 228
PEMS VGT VVQVTATDADDPTYGNSA+VVYSILQGQPYFSVE +TG+IKTAL NMDRE
Sbjct: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
Query: 229 REQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIG 288
++QY +VIQAKDM GQ GGLSGTT+V +TLTDVNDNPPRFP+ +YQ+ PES P + +
Sbjct: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
Query: 289 RIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVE 348
RIKA+DAD+G NAE+EY I DG+GL +F + D+ETQEGIIT++K LDFE K YTL++E
Sbjct: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
Query: 349 ASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQ 408
A+N +PRFL LGPF D+ TV+I+VEDVDEPPVFS Y +++ E Q+ IG+V A
Sbjct: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
Query: 409 DPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ 468
DPD++ +PV+YS+DR+TD++R FNID+ +G I T+K LDRET HNITV+A E NP Q
Sbjct: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
Query: 469 SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLA 528
R + I +LD+NDNAPEFA YET VCE A+ Q+IQ + AVDKD+P +GHQF FSL
Sbjct: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
Query: 529 PEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+A + NF+++DNKDNTA ILTR+NG+ R E S Y LP+ I D+ P SST T+T+RV
Sbjct: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
Query: 589 CACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIIS 648
C CD G Q+C+AEA + P GLSTGAL+AIL C++ LLV ++L +RR RKKEPLI
Sbjct: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRR-RKKEPLIFD 641
Query: 649 KE-DIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRT-PTA 706
+E DIR+NIV Y+DEGGGEEDT+AFD+ LRN I D K RRD+ PE FL R +
Sbjct: 642 EERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSI 701
Query: 707 RDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDY 766
DN R+FI +RLKE D DP APPYDSL TYA+EG GSVA+SLSSL+S+++++DQ+YDY
Sbjct: 702 PDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDY 761
Query: 767 LSDWGPRFKKLADMYG 782
LSDWGPRFK+LADMYG
Sbjct: 762 LSDWGPRFKRLADMYG 777
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 953 bits (2463), Expect = 0.0
Identities = 471/736 (63%), Positives = 578/736 (78%), Gaps = 3/736 (0%)
Query: 49 NRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTG 108
+R+KRSW+WNQFF+LEEY GSD YVGKLHSD D+GDGS+KYILSG+GA +FII+ENTG
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
Query: 109 DIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATV 168
DI ATKRLDREE+ Y LRAQA++R T +PVEPESEF+IKI DINDNEP F YTA V
Sbjct: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
Query: 169 PEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDREN 228
PEMS VGT VVQVTATDADDPTYGNSA+VVYSILQGQPYFSVE +TG+IKTAL NMDRE
Sbjct: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
Query: 229 REQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIG 288
++QY +VIQAKDM GQ GGLSGTT+V +TLTDVNDNPPRFP+ +YQ+ PES P + +
Sbjct: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
Query: 289 RIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVE 348
RIKA+DAD+G NAE+EY I DG+GL +F + D+ETQEGIIT++K LDFE K YTL++E
Sbjct: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
Query: 349 ASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQ 408
A+N +PRFL LGPF D+ TV+I+VEDVDEPPVFS Y +++ E Q+ IG+V A
Sbjct: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
Query: 409 DPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ 468
DPD++ +PV+YS+DR+TD++R FNID+ +G I T+K LDRET HNITV+A E NP Q
Sbjct: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
Query: 469 SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLA 528
R + I +LD+NDNAPEFA YET VCE A+ Q+IQ + AVDKD+P +GHQF FSL
Sbjct: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
Query: 529 PEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+A + NF+++DNKDNTA ILTR+NG+ R E S Y LP+ I D+ P SST T+T+RV
Sbjct: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
Query: 589 CACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIIS 648
C CD G Q+C+AEA + P GLSTGAL+AIL C++ LLV ++L +RR RKKEPLI
Sbjct: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRR-RKKEPLIFD 641
Query: 649 KE-DIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRT-PTA 706
+E DIR+NIV Y+DEGGGEEDT+AFD+ LRN I D K RRD+ PE FL R +
Sbjct: 642 EERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSI 701
Query: 707 RDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDY 766
DN R+FI +RLKE D DP APPYDSL TYA+EG GSVA+SLSSL+S+++++DQ+YDY
Sbjct: 702 PDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDY 761
Query: 767 LSDWGPRFKKLADMYG 782
LSDWGPRFK+LADMYG
Sbjct: 762 LSDWGPRFKRLADMYG 777
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 926 bits (2392), Expect = 0.0
Identities = 460/788 (58%), Positives = 582/788 (73%), Gaps = 9/788 (1%)
Query: 8 LLLFWVGQPYPTLSTPLSKRT---SGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLE 64
L++ W+ P P+++ SG P + +L G + LNRSKR W+WNQ F+LE
Sbjct: 16 LIILWITLPPCIYMAPMNQSQVLMSGSPLELNSL---GEEQRILNRSKRGWVWNQMFVLE 72
Query: 65 EYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVY 124
E++G + VG+LH+D D G +KYILSGDGAG +F IN+ TGDI A KRLDREEK Y
Sbjct: 73 EFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEY 132
Query: 125 ILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTAT 184
L AQA++ T +P+EP SEFIIK+ DINDN P F Y ATVPEMS +GT V VTAT
Sbjct: 133 TLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTAT 192
Query: 185 DADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQ 244
DADDP YGNSAK+VYSIL+GQPYFS+E ET IIKTAL NMDRE +E+Y VVIQAKDMGG
Sbjct: 193 DADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGH 252
Query: 245 MGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIE 304
GGLSGTTT+ +TLTDVNDNPP+F QS Y F PE GT IGR+KA+D D+GENA+
Sbjct: 253 SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSS 312
Query: 305 YSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPF 364
Y I DG+G +F++ +D + Q+GII ++K LDFE KK YTLKVEA+N +++PRF GPF
Sbjct: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPF 372
Query: 365 KDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRH 424
KD+ATV+IVVED DEPPVFS Y+L++ E+A +N+ IG VTA+DPD +P+++S+DRH
Sbjct: 373 KDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRH 432
Query: 425 TDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDN 484
TD++R FNI++ +G I + LDRE +WHNIT+IATEI N Q SRVP+ IKVLDVNDN
Sbjct: 433 TDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
Query: 485 APEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKD 544
APEFA YE F+CE K Q+IQT+ A+DKDDP +GH F +SL PE + NFTI+ N+D
Sbjct: 493 APEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNED 552
Query: 545 NTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEA 604
N+ IL + NG+NR + YLLP++ISD+ P SST T+T+RVC C + G +QSC+ EA
Sbjct: 553 NSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEA 612
Query: 605 LIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLII-SKEDIRDNIVSYNDEG 663
+ P GLS GAL+AIL CI++LLV VVLF LRR K EPLII ED+R+NI+ Y+DEG
Sbjct: 613 YVLPIGLSMGALIAILACIILLLVIVVLFVTLRR-HKNEPLIIKDDEDVRENIIRYDDEG 671
Query: 664 GGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRR-TPTARDNTDVRDFINQRLKE 722
GGEEDT+AFDI TL+NP+ I R+DI P+ F+PR+ + DV +FIN RL E
Sbjct: 672 GGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHE 731
Query: 723 NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
D DPTAPPYDS+ Y YEG GSVA SLSSLES T+D+DQ++DYLSDWGPRFK+L ++Y
Sbjct: 732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYS 791
Query: 783 GVDSDKDS 790
+SDK++
Sbjct: 792 VGESDKET 799
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 923 bits (2386), Expect = 0.0
Identities = 451/755 (59%), Positives = 575/755 (76%), Gaps = 6/755 (0%)
Query: 42 GNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLF 101
G L RSKR W+WNQFF++EEYTG D VG+LHSD D GDG++KYILSG+GAG +F
Sbjct: 42 GKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIF 101
Query: 102 IINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTK 161
+I++ +G+I ATK LDREE+ Y L AQA++R T RP+EP SEFI+K+ DINDN P F
Sbjct: 102 VIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLH 161
Query: 162 EVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTAL 221
E Y A VPE S+VGT V+QVTA+DADDPTYGNSAK+VYSIL+GQPYFSVE++TGII+TAL
Sbjct: 162 ETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTAL 221
Query: 222 LNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESS 281
NMDRE +E+Y VVIQAKDMGG MGGLSGTT V ITLTDVNDNPP+FPQS YQ E++
Sbjct: 222 PNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAA 281
Query: 282 PPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKK 341
PG +GR+KA D D+GEN + Y+I DG+G++ F++ TD ETQEG+I +KK +DFE K+
Sbjct: 282 VPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKR 341
Query: 342 VYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTT 401
Y+LKVEA+N +++P+F+ GPFKD+ TV+I VED DEPP+F +YI +++E+A T
Sbjct: 342 AYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTV 401
Query: 402 IGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIAT 461
+G V A+DPDAA +P++YS+DRHTD+DR F I+ +G I T+K LDRE W NITV A
Sbjct: 402 VGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAA 461
Query: 462 EINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCE----KAKADQLIQTLHAVDKDDP 517
EI+N Q ++VP+ I+VLDVNDNAP+FA YE F+CE K ++Q I T+ A DKDD
Sbjct: 462 EIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDT 521
Query: 518 YSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPV 577
+G +F FSL PE NFT++DN+DNTAG+ R+ G++R + YLLP+VISD P
Sbjct: 522 ANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPP 581
Query: 578 QSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALR 637
SST T+T++VC CD +G + SC+AEA I GLSTGAL+AIL CIVILLV VVLF LR
Sbjct: 582 MSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLR 641
Query: 638 RQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEAL 697
RQ+K+ ++ +ED+R+NI++Y+DEGGGEEDT+AFDI TL+NP+ I R+DI PE
Sbjct: 642 RQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQ 701
Query: 698 FLPR-RTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESV 756
++PR A ++ DV DFIN R++E D DPTAPPYDS+ Y YEG GSVA SLSSLES
Sbjct: 702 YMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESA 761
Query: 757 TTDADQDYDYLSDWGPRFKKLADMYGGVDS-DKDS 790
TTD+D DYDYL +WGPRFKKLAD+YG D+ D DS
Sbjct: 762 TTDSDLDYDYLQNWGPRFKKLADLYGSKDTFDDDS 796
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 922 bits (2382), Expect = 0.0
Identities = 458/759 (60%), Positives = 575/759 (75%), Gaps = 5/759 (0%)
Query: 29 SGFPAKKRALE-LSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGS 87
S P + LE L + R+KRSW+WNQFF+LEEYTG+D YVGKLHSD DRGDGS
Sbjct: 34 SDTPTPQGELEALLSDKPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKLHSDMDRGDGS 93
Query: 88 LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFII 147
+KYILSG+GAG +F I++ TGDI A +RLDREE+ Y LRAQA++RRTGRP+EPESEFII
Sbjct: 94 IKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGRPMEPESEFII 153
Query: 148 KIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPY 207
KI DINDNEP F Y ATVPEMS VGT V+QVTATDADDPTYGNSA+VVYSILQGQPY
Sbjct: 154 KIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARVVYSILQGQPY 213
Query: 208 FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
FSV+S+TG+I+TAL+NMDRE +E Y+V+IQAKDMGGQ+GGL+GTTTVNITL+DVNDNPPR
Sbjct: 214 FSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNITLSDVNDNPPR 273
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEG 327
FPQ YQ ES+P + +GR+ A D D G NAE++Y+I DG+G D FD+ TD Q G
Sbjct: 274 FPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPNFQVG 333
Query: 328 IITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLA 387
IITVKK L FE KK YTLKVE +NP++E RFL LGPF+D+ TV I VEDVDEPPVF
Sbjct: 334 IITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDVDEPPVFEPGF 393
Query: 388 YILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLD 447
Y +++ ED I TTI ++A+DPD N ++YS+DR +D R F +D G++ T++ LD
Sbjct: 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVDITTGALMTARPLD 453
Query: 448 RETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQ 507
RE WHNITV+A E+NNP Q VP+ IKVLDVNDNAPEF FYE FVCE AKA QLIQ
Sbjct: 454 REEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAPEFPRFYEAFVCENAKAGQLIQ 513
Query: 508 TLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLP 567
T+ AVD+DDP +G F +SLAPEAA+ NFTI+DN+DNTA ILTR++G+ + E S + LP
Sbjct: 514 TVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARILTRRSGFRQQEQSVFHLP 573
Query: 568 VVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILL 627
++I+D+ PV SSTGT+T++VC+CD G++ SC EA + P LS GAL+AIL CI +LL
Sbjct: 574 ILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVSLSRGALIAILACIFVLL 633
Query: 628 VTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDN- 686
V V+L ++RR RK+ +I +E+I +NIV Y+DEGGGEEDT+AFDI + NP +
Sbjct: 634 VLVLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGEEDTEAFDIAAMWNPREAQAGA 693
Query: 687 --KLRRDIVPEALFLPRRTP-TARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGT 743
K R+D++PE L R P T N+ V ++ +L E D D APP+DSL TY +EG
Sbjct: 694 APKTRQDMLPEIESLSRYVPQTCAVNSTVHSYVLAKLYEADMDLWAPPFDSLQTYMFEGD 753
Query: 744 GSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
GSVA SLSSL+S T+D++Q +D+L+DWGPRF+KLA++YG
Sbjct: 754 GSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 915 bits (2364), Expect = 0.0
Identities = 443/741 (59%), Positives = 576/741 (77%), Gaps = 2/741 (0%)
Query: 49 NRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTG 108
+R KR W+WNQFF+LEE+ G D QYVGKLHS+ D+GDGS+KYIL+G+GAG +FII++ TG
Sbjct: 49 HRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTG 108
Query: 109 DIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATV 168
DI +TK LDRE+K Y+L AQAI+RRT +P+EPESEFIIK+ DINDN P FT Y TV
Sbjct: 109 DIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTV 168
Query: 169 PEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDREN 228
PEMSD+GT V+QVTATDADDPTYGNSA+VVYSILQGQPYFSV+ +TG+I+TAL NMDRE
Sbjct: 169 PEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREA 228
Query: 229 REQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIG 288
RE Y VVIQAKDM GQ+GGLSG+TTVNITLTDVNDNPPRFPQ YQ PES+ G+ +G
Sbjct: 229 REHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVG 288
Query: 289 RIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVE 348
+IKA+DAD G NA++ YSI +G+G+ +F + TD+ET+EGI+++KK L++EKKK YTL +E
Sbjct: 289 KIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIE 348
Query: 349 ASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQ 408
+N +++ RF +LGPFKD+ ++I+V DVDEPP+FS +Y++++ E+A+I T +G+V AQ
Sbjct: 349 GANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQ 408
Query: 409 DPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ 468
DPD+ + V+Y ++ + + DR FNID+ G+I T+K+LDRE W+NITV A+EI+NP
Sbjct: 409 DPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDL 468
Query: 469 SSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLA 528
S V + I+VLDVNDN PE A Y+ VCE +K Q+I T+ A DKDD +G +F+F L
Sbjct: 469 LSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLD 528
Query: 529 PEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
NFT++DN+DNTA ILTR+ ++R Y LP++ISD P SS+ T+T+RV
Sbjct: 529 ERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRV 588
Query: 589 CACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIIS 648
CAC+ G +++CHAEA + GLSTGAL+AILLC++ILL VVLF LRR KKEPLIIS
Sbjct: 589 CACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRS-KKEPLIIS 647
Query: 649 KEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPR-RTPTAR 707
+ED+R+N+V+Y+DEGGGEEDT+AFDI LRNP A E+ K RRDI PE PR +T +
Sbjct: 648 EEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTL 707
Query: 708 DNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYL 767
++ DV++FI QRL E D DP+ PPYDSL TYAYEG S A S+SSL+S TT +DQDY YL
Sbjct: 708 ESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYL 767
Query: 768 SDWGPRFKKLADMYGGVDSDK 788
DWGP FKKLA++YG ++S++
Sbjct: 768 GDWGPEFKKLAELYGEIESER 788
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 788 bits (2034), Expect = 0.0
Identities = 401/809 (49%), Positives = 549/809 (67%), Gaps = 29/809 (3%)
Query: 8 LLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYT 67
LLL + P PTL L + P+ A + + R KR W+WNQFF++EEYT
Sbjct: 20 LLLLLLLPPPPTLLGRLWAAGTPSPSAPGARQ---DGALGAGRVKRGWVWNQFFVVEEYT 76
Query: 68 GSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILR 127
G++ YVGK+HSD D GDG++KY +SG+GAG +F+I+E TGDI A +RLDRE+K Y LR
Sbjct: 77 GTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLR 136
Query: 128 AQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDAD 187
AQA +R T R +EPESEFIIK+ DIND+EP F Y +V E+S GT V+QV A+DAD
Sbjct: 137 AQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDAD 196
Query: 188 DPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGG 247
DPTYG+SA++VYS+L G+ +F+V+ +TG+I+TA+ ++DRE++E+Y+VVIQA DM GQ+GG
Sbjct: 197 DPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGG 256
Query: 248 LSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSI 307
LSG+TTV I +TDVNDNPPRFPQ YQF ES+P GT +GR+KA D+DVGEN ++ Y +
Sbjct: 257 LSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHL 316
Query: 308 TD--GEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFK 365
D G D+F V TD +TQE II V+K LDFE + V+T+ +EA N +V+PRF LG F+
Sbjct: 317 KDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFR 376
Query: 366 DSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHT 425
D A VR+ V DVDEPP F + +L+++EDAQ+ + +G VTA+DPDAA PV+Y++DR +
Sbjct: 377 DQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRES 436
Query: 426 DMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNA 485
D+D+IF+ID+ G+I T K LDRET WHNITV+A E +N Q SR L I++LDVNDN
Sbjct: 437 DLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDVNDNP 496
Query: 486 PEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDN 545
PE A YE VCE AK QLIQT+ VD+D+P GH+F F L PEA S +F++ D +DN
Sbjct: 497 PELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQDN 556
Query: 546 TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEAL 605
TA + T+ G+NR E + LP+++ D+ P SSTGT+T+R+C CD G +QSC+ A
Sbjct: 557 TAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTTAF 616
Query: 606 IHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGG 665
+ LS GAL+A+L+C++IL+V V+L LRR K ED+RDN++ YNDEGGG
Sbjct: 617 VMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYNDEGGG 676
Query: 666 EEDTQAFDIGTLRNPEAIEDNK-----------------------LRRDIVPEALFLPRR 702
E+DT+A+D+ LR+ + K + + E LP+
Sbjct: 677 EQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSLPQG 736
Query: 703 TPTARDNTDV-RDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDAD 761
P+ + V RDFI++++ D D + PPYD+ TYA+EG S A SLSSL S ++ ++
Sbjct: 737 PPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSSGSE 796
Query: 762 QDYDYLSDWGPRFKKLADMYGGVDSDKDS 790
QD+ YLS WGPRF+ LA +Y G D ++
Sbjct: 797 QDFAYLSSWGPRFRPLAALYAGHRGDDEA 825
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 757 bits (1955), Expect = 0.0
Identities = 381/744 (51%), Positives = 523/744 (70%), Gaps = 17/744 (2%)
Query: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENT 107
L R++RSW+WNQFF++EEY G + +GKLHSD DRG+G KY+L+G+GAG +F+I+E T
Sbjct: 39 LLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEAT 98
Query: 108 GDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTAT 167
G+I TK LDREEK Y+L AQA++R + RP+EP SEFIIK+ DINDN PIF Y AT
Sbjct: 99 GNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHAT 158
Query: 168 VPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRE 227
VPEMS+VGT V+QVTA DADDP+YGNSAK+VY++L G P+FSV+ +TG+++TA+ NMDRE
Sbjct: 159 VPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRE 218
Query: 228 NREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPI 287
+E++ VVIQAKDMGG MGGLSG+TTV +TL+DVNDNPP+FPQS YQF E++ PGT +
Sbjct: 219 TQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLV 278
Query: 288 GRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKV 347
GR++A D D+G+NA + YSI DGEG + F + TD + ++G++TV+K LDFE ++ Y+ +V
Sbjct: 279 GRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRV 338
Query: 348 EASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTA 407
EA+N ++P +L GPFKD A+VR+ V+D EPP F++ AY L + E+ T +G ++A
Sbjct: 339 EATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISA 398
Query: 408 QDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPK 467
D D+ +P++YS+ H+D +R F+I G+I T+ LDRE WHN+TV+ATE+++
Sbjct: 399 ADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELDSSA 458
Query: 468 QSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFS- 526
Q+SRV + I+ LD NDNAP+ AE Y+TFVC+ A QLIQ + A+D+D+ + SF
Sbjct: 459 QASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQG 518
Query: 527 -LAPEAASGSNFTIQDNKDNTAG-ILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTV 584
L P+A NFT+QDN+D +A +L + RH + YL+P+ + D P SST TV
Sbjct: 519 PLGPDA----NFTVQDNRDGSASLLLPSRPAPPRH--APYLVPIELWDWGQPALSSTATV 572
Query: 585 TVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEP 644
TV VC C G++ SC EA + GLSTGAL+AI+ C+ LL VVLF ALRRQ+++
Sbjct: 573 TVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEAL 632
Query: 645 LIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEA----IEDNKLRRDIVPEALFLP 700
+++ +ED+R+NI++Y+DEGGGEEDT+AFDI L+NP+ RRD++P A
Sbjct: 633 MVLEEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARV-- 690
Query: 701 RRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTT-- 758
R P DV + RL+E D DP PPYDS+ Y YEG GS SLSSL S +
Sbjct: 691 SRQPRPPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAG 750
Query: 759 DADQDYDYLSDWGPRFKKLADMYG 782
A + L DWGP F+ LA++YG
Sbjct: 751 GAPGPAEPLDDWGPLFRTLAELYG 774
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 738 bits (1906), Expect = 0.0
Identities = 381/782 (48%), Positives = 523/782 (66%), Gaps = 55/782 (7%)
Query: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENT 107
L R++RSW+WNQFF++EEY G + +GKLHSD DRG+G KY+L+G+GAG +F+I+E T
Sbjct: 39 LLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEAT 98
Query: 108 GDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTAT 167
G+I TK LDREEK Y+L AQA++R + RP+EP SEFIIK+ DINDN PIF Y AT
Sbjct: 99 GNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHAT 158
Query: 168 VPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRE 227
VPEMS+VGT V+QVTA DADDP+YGNSAK+VY++L G P+FSV+ +TG+++TA+ NMDRE
Sbjct: 159 VPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRE 218
Query: 228 NREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPI 287
+E++ VVIQAKDMGG MGGLSG+TTV +TL+DVNDNPP+FPQS YQF E++ PGT +
Sbjct: 219 TQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLV 278
Query: 288 GRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKV 347
GR++A D D+G+NA + YSI DGEG + F + TD + ++G++TV+K LDFE ++ Y+ +V
Sbjct: 279 GRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRV 338
Query: 348 EASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTA 407
EA+N ++P +L GPFKD A+VR+ V+D EPP F++ AY L + E+ T +G ++A
Sbjct: 339 EATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISA 398
Query: 408 QDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEI---- 463
D D+ +P++YS+ H+D +R F+I G+I T+ LDRE WHN+TV+ATE+
Sbjct: 399 ADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSW 458
Query: 464 ----------------------------------NNPKQSSRVPLYIKVLDVNDNAPEFA 489
++ Q+SRV + I+ LD NDNAP+ A
Sbjct: 459 GPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLA 518
Query: 490 EFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFS--LAPEAASGSNFTIQDNKDNTA 547
E Y+TFVC+ A QLIQ + A+D+D+ + SF L P+A NFT+QDN+D +A
Sbjct: 519 EPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDA----NFTVQDNRDGSA 574
Query: 548 G-ILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALI 606
+L + RH + YL+P+ + D P SST TVTV VC C G++ SC EA +
Sbjct: 575 SLLLPSRPAPPRH--APYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHL 632
Query: 607 HPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGE 666
GLSTGAL+AI+ C+ LL VVLF ALRRQ+++ +++ +ED+R+NI++Y+DEGGGE
Sbjct: 633 SAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGE 692
Query: 667 EDTQAFDIGTLRNPEA----IEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKE 722
EDT+AFDI L+NP+ RRD++P A R P DV + RL+E
Sbjct: 693 EDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARV--SRQPRPPGPADVAQLLALRLRE 750
Query: 723 NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTT--DADQDYDYLSDWGPRFKKLADM 780
D DP PPYDS+ Y YEG GS SLSSL S + A + L DWGP F+ LA++
Sbjct: 751 ADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAEL 810
Query: 781 YG 782
YG
Sbjct: 811 YG 812
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 707 bits (1825), Expect = 0.0
Identities = 371/778 (47%), Positives = 520/778 (66%), Gaps = 17/778 (2%)
Query: 6 YFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEE 65
Y LL F +G P L P T KK + + R KR W+WNQFF+ EE
Sbjct: 4 YLLLRFMLGIP---LLWPCLGATENSQTKKVKQPVRSHL-----RVKRGWVWNQFFVPEE 55
Query: 66 YTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYI 125
+ + ++G+L SD D G+ S +Y L G GAG FII+E TGDI A ++LDREE+ +YI
Sbjct: 56 MNTTSH-HIGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYI 114
Query: 126 LRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATD 185
LRAQ I+ TGR VEPESEF+IK+ DINDNEP F E Y A VPEMS GT V+QVTA+D
Sbjct: 115 LRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASD 174
Query: 186 ADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQM 245
ADDP+ GN+A+++YS+LQGQPYFSVE TG+I+ + MDRE +++Y V+IQAKDM GQ
Sbjct: 175 ADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRISS-KMDRELQDEYWVIIQAKDMIGQP 233
Query: 246 GGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEY 305
G LSGTT+V I L+DVNDN P F +S Y+ ES+P GT IG I A D D+GENAE++Y
Sbjct: 234 GALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDY 293
Query: 306 SITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFK 365
SI + + FD+IT+ ETQEGI+ +KK +DFE + Y ++ + N +V + +
Sbjct: 294 SIEEDDS-QTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEA 352
Query: 366 DSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHT 425
+ ++I VEDVDEPP+F Y+ ++ E+ + +G V+A DPD ++P++YS+ R
Sbjct: 353 STTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITR-- 410
Query: 426 DMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNA 485
++FNI+ NG+I TS LDRE W+N+++ ATE N +Q S +PLY++VL++ND+A
Sbjct: 411 --SKVFNIND-NGTITTSNSLDREISAWYNLSITATEKYNIEQISSIPLYVQVLNINDHA 467
Query: 486 PEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDN 545
PEF+++YET+VCE A + Q+IQT+ AVD+D+ H F F+L+ E + S+FTI DN+DN
Sbjct: 468 PEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDN 527
Query: 546 TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEAL 605
TA ILT + G+N E + + ++I+DN P +ST T+T+ VC C G+ Q+C + L
Sbjct: 528 TAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQEL 587
Query: 606 IHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGG 665
+ G T ++AIL+CI+I+ + L L+++RK+ ED R+NI Y+DEGGG
Sbjct: 588 VLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGG 647
Query: 666 EEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRT-PTARDNTDVRDFINQRLKEND 724
EEDT+AFDI LR+ + + K R+ E L R++ D+ R FI ++L+E +
Sbjct: 648 EEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFILEKLEEAN 707
Query: 725 TDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
TDP APP+DSL TYA+EGTGS+A SLSSLES +D D+ YDYL++ GPRFK+LA M+G
Sbjct: 708 TDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFG 765
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 530 bits (1365), Expect = e-150
Identities = 308/749 (41%), Positives = 450/749 (60%), Gaps = 33/749 (4%)
Query: 50 RSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGD 109
R KR W+WNQ + EE S +VGK+ S R + KY+L G+ G +F ++ TGD
Sbjct: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGD 101
Query: 110 IQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVP 169
+ A +RLDRE Y L A +++ TG +E S F IK+HD+NDN P+FT ++ A+VP
Sbjct: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
Query: 170 EMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENR 229
E S VGT V+ VTA DADDPT G+ A V+Y IL+G+ YF++++ +G I T ++DRE +
Sbjct: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDN-SGRIITITKSLDREKQ 220
Query: 230 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGR 289
+Y++V++A+D G + G SGT TV +TL D+NDN P F Q+ Y F PE + GT +G
Sbjct: 221 ARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
Query: 290 IKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEA 349
+ D D +N +YSI G+ D F + T+ EGII K LD+E + Y+ VEA
Sbjct: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
Query: 350 SNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQD 409
++P ++ R++ P + A V I + DVDEPP+F + Y Q++E+ Q IG+V A D
Sbjct: 340 TDPTIDLRYM-SPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN-QKKPLIGTVLAMD 397
Query: 410 PDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINN---- 465
PDAAR+ + YS+ R +D + F + + G I+ K LDRE W+N+TV A E+++
Sbjct: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
Query: 466 PKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSF 525
+ S V ++I+VLD NDNAPEFA+ Y+ VCE A QL+ + A+DKD +F F
Sbjct: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
Query: 526 SLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVT 585
L E +NFT+ DN DNTA I + ++R + LPVVISDN P ++ T T+T
Sbjct: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
Query: 586 VRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIV-ILLVTVVLFAALRRQRKKEP 644
V VC C+ G C E + G+S A+VAILLCI+ I ++T+++F LRR+ +K+
Sbjct: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIF--LRRRLRKQA 628
Query: 645 LIISKE--DIRDNIVSYNDEGGGEEDTQAFDIGTLRN--------PEAIEDNKLRRDIVP 694
K +I + +V+Y++EGGGE DT ++D+ L + P D R +
Sbjct: 629 RAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALD--ARPSLYA 686
Query: 695 EALFLPRRTPTARDNT-DVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSL 753
+ PR P A ++ I + E D D PPYD+L Y YEG+ S+A+SLSSL
Sbjct: 687 QVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSL 746
Query: 754 ESVTTDADQDYDYLSDWGPRFKKLADMYG 782
+ ++D+D DYD+L+DWGPRFK LA++YG
Sbjct: 747 GTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 429 bits (1102), Expect = e-120
Identities = 290/774 (37%), Positives = 415/774 (53%), Gaps = 51/774 (6%)
Query: 46 NELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAG----DLF 101
N L R KR W+ + E G Q + ++ SD+D D ++Y ++G GA ++F
Sbjct: 162 NGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDN-DIPIRYSITGVGADQPPMEVF 220
Query: 102 IINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTK 161
I+ +G + T+ +DREE Y LRA A++ G VE + I + D+NDN P F
Sbjct: 221 SIDSMSGRMYVTRPMDREEHASYHLRAHAVDMN-GNKVENPIDLYIYVIDMNDNRPEFIN 279
Query: 162 EVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPY------FSVESETG 215
+VY +V E S GT+V+ VTA DADD T N V Y I+ P F++ SETG
Sbjct: 280 QVYNGSVDEGSKPGTYVMTVTANDADDSTTANGM-VRYRIVTQTPQSPSQNMFTINSETG 338
Query: 216 IIKTALLNMDRENREQYQVVIQAKDMGGQMG-GLSGTTTVNITLTDVNDNPPRFPQSTYQ 274
I T +DRE +QY V++QA DM G + GLS T T IT+TDVNDNPP F ST+
Sbjct: 339 DIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFA 398
Query: 275 FKTPESSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQETQEGIITVK 332
+ PE+ T + + D D N Y I G+ F V TD T EG++TV
Sbjct: 399 GEVPENRVE-TVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVV 457
Query: 333 KLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQI 392
K +D+E + + L V SN + + F+ +A V I + D++E P F ++++
Sbjct: 458 KAVDYELNRAFMLTVMVSNQAPLASGIQMS-FQSTAGVTISIMDINEAPYFPSNHKLIRL 516
Query: 393 REDAQINTTIGSVTAQDPDA-ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETL 451
E T + + +A DPD + V+YS + +D +I++ NG I T+ +LDRE+L
Sbjct: 517 EEGVPPGTVLTTFSAVDPDRFMQQAVRYS--KLSDPASWLHINATNGQITTAAVLDRESL 574
Query: 452 LWHN----ITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQ 507
N T +A + P S L I ++D+NDNAPE E +CEK + +
Sbjct: 575 YTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLP-KEAQICEKPNLNAINI 633
Query: 508 TLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLP 567
T D D + F P AA N+TI + A + R E Y +P
Sbjct: 634 TAADADVDPNIGPYVFELPFVP-AAVRKNWTITRLNGDYAQLSLR---ILYLEAGMYDVP 689
Query: 568 VVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILL 627
++++D+ P S+T + V+VC CD +G+ C + GL TGA+VAIL+CI+ILL
Sbjct: 690 IIVTDSGNPPLSNTSIIKVKVCPCDDNGD---CTTIGAVAAAGLGTGAIVAILICILILL 746
Query: 628 VTVVLFAALRRQRKKEP-----LIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEA 682
V+LF ++R+KE LI ++D+RDNI+ Y++EGGGEED Q +D+ L+ PEA
Sbjct: 747 TMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEED-QDYDLSQLQQPEA 805
Query: 683 IEDNKLR---------RDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYD 733
+ + R + E + R P D+ DFIN+ L+ D DPTAPPYD
Sbjct: 806 MGHVPSKAPGVRRVDERPVGAEPQYPIR--PMVPHPGDIGDFINEGLRAADNDPTAPPYD 863
Query: 734 SLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSD 787
SL + YEG+GS A S+SSL S ++ DQDYDYL+DWGPRFKKLADMYGG + D
Sbjct: 864 SLLVFDYEGSGSTAGSVSSLNS-SSSGDQDYDYLNDWGPRFKKLADMYGGGEED 916
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 426 bits (1095), Expect = e-119
Identities = 295/779 (37%), Positives = 423/779 (54%), Gaps = 68/779 (8%)
Query: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFII 103
L R KR W+ L E G Q + ++ SD+D+ + SL+Y ++G GA +FII
Sbjct: 154 LQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDK-NLSLRYSVTGPGADQPPTGIFII 212
Query: 104 NENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEV 163
N +G + TK LDRE+ + LRA A++ G VE + +I + D+NDN P F +V
Sbjct: 213 NPISGQLSVTKPLDREQIARFHLRAHAVDIN-GNQVENPIDIVINVIDMNDNRPEFLHQV 271
Query: 164 YTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGII 217
+ TVPE S GT+V+ VTA DADDP N + Y I+ P F++ +ETG I
Sbjct: 272 WNGTVPEGSKPGTYVMTVTAIDADDPNALNGM-LRYRIVSQAPSTPSPNMFTINNETGDI 330
Query: 218 KTALLNMDRENREQYQVVIQAKDM-GGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFK 276
T +DRE +QY ++IQA DM G GLS T T IT+TDVNDNPP F T+ +
Sbjct: 331 ITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGE 390
Query: 277 TPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQEGIITVKKL 334
PE+ + + +D D Y I+ G+ F + TD + +G++TV K
Sbjct: 391 VPENRVD-IIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKP 449
Query: 335 LDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIRE 394
+DFE +++ L V A N + + P + +ATV + V DV+E P F+ I++ E
Sbjct: 450 IDFETNRMFVLTVAAENQVPLAKGIQHPP-QSTATVSVTVIDVNENPYFAPNPKIIRQEE 508
Query: 395 DAQINTTIGSVTAQDPDA-ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLW 453
T + + TAQDPD + ++Y+ + +D ID NG I T +LDRE+
Sbjct: 509 GLHAGTMLTTFTAQDPDRYMQQNIRYT--KLSDPANWLKIDPVNGQITTIAVLDRESPNV 566
Query: 454 ----HNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTL 509
+N T +A++ P S L I +LD+NDNAP+ E CE + + +
Sbjct: 567 KNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLP-QEAETCETPDPNSI--NI 623
Query: 510 HAVDKD-DPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRH--------E 560
A+D D DP +G F+F L S TI+ N +TR NG E
Sbjct: 624 TALDYDIDPNAG-PFAFDLPL-----SPVTIKRN-----WTITRLNGDFAQLNLKIKFLE 672
Query: 561 MSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAIL 620
Y +P++I+D+ P +S+ + V+VC CD +G+ C I GL TGA++AIL
Sbjct: 673 AGIYEVPIIITDSGNPPKSNISILRVKVCQCDSNGD---CTDVDRIVGAGLGTGAIIAIL 729
Query: 621 LCIVILLVTVVLFAALRRQRKKEP-----LIISKEDIRDNIVSYNDEGGGEEDTQAFDIG 675
LCI+ILL+ V++F ++R KE LI ++D+RDNI+ Y++EGGGEED Q +D+
Sbjct: 730 LCIIILLILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEED-QDYDLS 788
Query: 676 TLRNPEAIEDNKLR---------RDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTD 726
L+ P+ +E + ++ R I E + R A D+ DFIN+ LK D D
Sbjct: 789 QLQQPDTVEPDAIKPVGIRRMDERPIHAEPQYPVRSA--APHPGDIGDFINEGLKAADND 846
Query: 727 PTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVD 785
PTAPPYDSL + YEG+GS A SLSSL S ++ +QDYDYL+DWGPRFKKLADMYGG D
Sbjct: 847 PTAPPYDSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGD 905
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 393 bits (1010), Expect = e-109
Identities = 289/814 (35%), Positives = 418/814 (51%), Gaps = 60/814 (7%)
Query: 6 YFLLLFWVGQPYPTLSTPLSKRTSGF---PAKKRALELSG---------NSKNELNRSKR 53
+FL+ W Y ST ++ T G P +A +SG NS L R KR
Sbjct: 97 HFLVYAW-DSTYRKFSTKVTLNTVGHHHRPPPHQA-SVSGIQAELLTFPNSSPGLRRQKR 154
Query: 54 SWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFIINENTGD 109
W+ E G + + ++ S++D+ +G + Y ++G GA +FII TG
Sbjct: 155 DWVIPPISCPENEKGPFPKNLVQIKSNKDK-EGKVFYSITGQGADTPPVGVFIIERETGW 213
Query: 110 IQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVP 169
++ T+ LDRE Y L + A++ G VE E +I + D NDN+P FT+EV+ +V
Sbjct: 214 LKVTEPLDRERIATYTLFSHAVSSN-GNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVM 272
Query: 170 EMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETGIIKTALLN 223
E + GT V++VTATDADD +A + Y+IL P F++ TG+I
Sbjct: 273 EGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTG 332
Query: 224 MDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPP 283
+DRE+ Y +V+QA D+ G+ GLS T T IT+TD NDNPP F +TY+ + PE+
Sbjct: 333 LDRESFPTYTLVVQAADLQGE--GLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEA- 389
Query: 284 GTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKK 341
I +K +DAD E Y+I + +G F V T+ +GI+ K LDFE K+
Sbjct: 390 NVVITTLKVTDADAPNTPAWEAVYTILNDDG-GQFVVTTNPVNNDGILKTAKGLDFEAKQ 448
Query: 342 VYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTT 401
Y L V +N V P + L +ATV + V DV+E P+F +++ ED +
Sbjct: 449 QYILHVAVTN--VVPFEVSLTT--STATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQE 504
Query: 402 IGSVTAQDPDA-ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETL-----LWHN 455
I S TAQ+PD + Y + R D I+ G+I T LDRE +
Sbjct: 505 ITSYTAQEPDTFMEQKITYRIWR--DTANWLEINPDTGAISTRAELDREDFEHVKNSTYT 562
Query: 456 ITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKD 515
+IAT+ +P + L + + DVNDNAP E F CE+ Q+I + +D D
Sbjct: 563 ALIIATDNGSPVATGTGTLLLILSDVNDNAP-IPEPRTIFFCERNPKPQVI---NIIDAD 618
Query: 516 DPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDY 575
P + F+ L A++ N+TIQ N I+ + E+ Y + + + DN
Sbjct: 619 LPPNTSPFTAELTHGASA--NWTIQYNDPTQESIILKPK--MALEVGDYKINLKLMDN-- 672
Query: 576 PVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAA 635
Q+ T+ V CD G C + GL A++ IL I+ LL+ ++L
Sbjct: 673 --QNKDQVTTLEVSVCDCEGAAGVCRKAQPVE-AGLQIPAILGILGGILALLILILLLLL 729
Query: 636 LRRQRK--KEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIV 693
R+R KEPL+ ++D RDN+ Y++EGGGEED Q FD+ L R D+
Sbjct: 730 FLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEED-QDFDLSQLHRGLDARPEVTRNDVA 788
Query: 694 PEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSL 753
P + +PR P + ++ +FI++ LK DTDPTAPPYDSL + YEG+GS A SLSSL
Sbjct: 789 PTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSL 848
Query: 754 ESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSD 787
S +D DQDYDYL++WG RFKKLADMYGG + D
Sbjct: 849 NSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD 882
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 365 bits (938), Expect = e-101
Identities = 260/759 (34%), Positives = 394/759 (51%), Gaps = 41/759 (5%)
Query: 48 LNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFII 103
L+R +R+W+ + E + Y V ++ SD+ + GS+ Y + G G + +F I
Sbjct: 40 LSRVRRAWVIPPISVSENHKRLPYPLV-QIKSDKQQL-GSVIYSIQGPGVDEEPRGVFSI 97
Query: 104 NENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEV 163
++ TG + LDRE+ + LRA A++ G +E ++ I + D NDN P F +E
Sbjct: 98 DKFTGKVFLNAMLDREKTDRFRLRAFALDLG-GSTLEDPTDLEIVVVDQNDNRPAFLQEA 156
Query: 164 YTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP-YFSVESETGIIKTALL 222
+T V E + GT+V + ATDADDP N+A + QG P FS++ TG I+T +
Sbjct: 157 FTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQV 216
Query: 223 NMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSP 282
+DRE Y + +Q DM G GL+ T + ITL D+NDN P F + + + E+
Sbjct: 217 GLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVS 274
Query: 283 PGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKK 340
G +GR++ D D+ N ++I +G+ F + TD +T EG++++ K LD+E
Sbjct: 275 -GVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESC 333
Query: 341 KVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINT 400
+ Y LKV N + L + A VR+ V+D +EPPVF + + E A T
Sbjct: 334 EHYELKVSVQNE-APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGT 392
Query: 401 TIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLL----WHNI 456
+ + +A+DPD + + S + D + +D+ G I T +L + W+
Sbjct: 393 LVATFSARDPDTEQLQ-RLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRA 451
Query: 457 TVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDD 516
V+A + + +++ L I++L+VND+AP A +C + + L A D+D
Sbjct: 452 IVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDEDL 510
Query: 517 PYSGHQFSFSLAPEAAS-GSNFTIQDNKDNTAGILTRKNGYNRHEMSTYL--LPVVISDN 573
P G F F L+P G N+++ + A + R H++ L L +++ D+
Sbjct: 511 PPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPR------HQVPEGLHRLSLLLRDS 564
Query: 574 DYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLF 633
P Q + V VC C G A L TGLS GALV +L ++LLV V+L
Sbjct: 565 GQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLV 624
Query: 634 AALRR----QRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIE----D 685
A R R K L ++D+RDN+++Y+++GGGEED A+DI LR+P A+
Sbjct: 625 ALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGP 684
Query: 686 NKLRRDIVPEALFL--PRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGT 743
LRRD L PR PT+ D+ DFIN L+ D+DP+ PPYD+ Y YEG
Sbjct: 685 PPLRRDAPQGRLHPQPPRVLPTSP--LDIADFINDGLEAADSDPSVPPYDTALIYDYEGD 742
Query: 744 GSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
GSVA +LSS+ S D DQDYDYL DWGPRF +LADMYG
Sbjct: 743 GSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYG 781
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 365 bits (937), Expect = e-101
Identities = 262/766 (34%), Positives = 394/766 (51%), Gaps = 56/766 (7%)
Query: 44 SKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD---- 99
SK L R KR W+ + E G Q + +L S++DR D + Y ++G GA
Sbjct: 98 SKRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDR-DTKIFYSITGPGADSPPEG 156
Query: 100 LFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIF 159
+F + + TG + K LDREE Y L A++ G VE I + D ND++P F
Sbjct: 157 VFAVEKETGWLLLNKPLDREEIAKYELFGHAVSEN-GASVEDPMNISIIVTDQNDHKPKF 215
Query: 160 TKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESE 213
T++ + +V E GT V+QVTATD DD Y + V YSI +P F++
Sbjct: 216 TQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRS 275
Query: 214 TGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTY 273
TG I +DRE +Y + IQA DM G G + T + + D NDN P F Y
Sbjct: 276 TGTISVISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVVEILDANDNAPMFDPQKY 333
Query: 274 QFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQEGIITV 331
+ PE++ G + R+ +D D + Y I G+ D F + T E+ +GI+T
Sbjct: 334 EAHVPENAV-GHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTT 392
Query: 332 KKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQ 391
+K LDFE K +TL VE +N E F+ P +AT+ + VEDV+E PVF + +++
Sbjct: 393 RKGLDFEAKNQHTLYVEVTN---EAPFVLKLP-TSTATIVVHVEDVNEAPVFVPPSKVVE 448
Query: 392 IREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETL 451
++E + TA+DPD + Y + R D +D +G + LDRE
Sbjct: 449 VQEGIPTGEPVCVYTAEDPDKENQKISYRILR--DPAGWLAMDPDSGQVTAVGTLDREDE 506
Query: 452 LW-----HNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLI 506
+ + + V+A + +P + L + ++DVND+ P E + +C ++ Q+
Sbjct: 507 QFVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP-VPEPRQITICNQSPVRQV- 564
Query: 507 QTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLL 566
L+ DKD S H F S +T + N++ +L+ K + TY +
Sbjct: 565 --LNITDKD--LSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQ---DTYDV 617
Query: 567 PVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAE---ALIHPTGLSTGALVAILLCI 623
+ +SD+ Q + +R CD HG++++C I P GA++A+L +
Sbjct: 618 HLSLSDHGNKEQLTV----IRATVCDCHGHVETCPGPWKGGFILPV---LGAVLALLFLL 670
Query: 624 VILLVTVVLFAALRRQRK-KEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTL-RNPE 681
++LL+ V R++RK KEPL++ ++D RDN+ Y +EGGGEED Q +DI L R E
Sbjct: 671 LVLLLLV------RKKRKIKEPLLLPEDDTRDNVFYYGEEGGGEED-QDYDITQLHRGLE 723
Query: 682 AIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYE 741
A + LR D+ P + P P + ++ +FI + LK +TDPTAPPYD+L + YE
Sbjct: 724 ARPEVVLRNDVAPTIIPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYE 783
Query: 742 GTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSD 787
G+GS A SLSSL S +D DQDYDYL++WG RFKKLADMYGG + D
Sbjct: 784 GSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD 829
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 247 bits (631), Expect = 3e-65
Identities = 236/803 (29%), Positives = 364/803 (45%), Gaps = 84/803 (10%)
Query: 34 KKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILS 93
+K+ + + L R+KR W + E G ++ ++ SD + + ++ Y +S
Sbjct: 116 QKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSIS 174
Query: 94 GDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKI 149
G G +LF I +TG++ T+ +DREE V+ L A A + G + I++
Sbjct: 175 GRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRV 233
Query: 150 HDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP--- 206
D NDN P+FT+ +Y V E S GT V V ATD D+P ++ ++ YSILQ P
Sbjct: 234 EDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSP 292
Query: 207 -YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265
FSV TG+I T +DRE ++Y ++++ +DM GQ GL GT+T IT+TD NDN
Sbjct: 293 GLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNA 352
Query: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQE 323
P F Q+ Y+ E++ I RI D D+ N + ++I G F + TD+E
Sbjct: 353 PTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKE 411
Query: 324 TQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVF 383
T EG+++V K L++E+ + L++ +N R + + A V + V D+DE P
Sbjct: 412 TNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPEC 471
Query: 384 SKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTS 443
+ A ++I+E+ + + I A DP+ RN + D ID +GSI TS
Sbjct: 472 TPAAQYVRIKENLAVGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITS 530
Query: 444 KLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEK 499
K+LDRE +NITV+A I+ +S L + + DVNDN PE + Y K
Sbjct: 531 KILDREVETPKNELYNITVLA--IDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPK 588
Query: 500 AKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRH 559
++ AVD D+P G F FSL + S ++TA L+ +
Sbjct: 589 MGYTDIL----AVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
Query: 560 EMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAI 619
E Y +P+ + D Q++T + V +C C H C A + L A++AI
Sbjct: 645 E---YTIPITVKDR--AGQAATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAI 696
Query: 620 LLCIVIL---LVTVV--LFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEE---DTQA 671
LL I +L L+T+V +F A + +R E L + N++ N E G++
Sbjct: 697 LLGIALLFSVLLTLVCGVFGATKGKRFPEDL------AQQNLIISNTEAPGDDRVCSANG 750
Query: 672 FDIGTLRN-----------------PEAIEDNKLRRDIVP--------EALFLPRRTPTA 706
F T N E IE K + L R T
Sbjct: 751 FMTQTTNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTE 810
Query: 707 RDN-----TDVRDFINQRLKE-----NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESV 756
DN ++ F RL E N + P D + TY YEG GS A S+
Sbjct: 811 VDNCRYTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGCCSE- 869
Query: 757 TTDADQDYDYLSDWGPRFKKLAD 779
+ D+L++ P+F LA+
Sbjct: 870 -KQEEDGLDFLNNLEPKFITLAE 891
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 240 bits (612), Expect = 4e-63
Identities = 202/653 (30%), Positives = 318/653 (48%), Gaps = 44/653 (6%)
Query: 34 KKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILS 93
+K+ + + L R+KR W + E G ++ ++ SD + + ++ Y +S
Sbjct: 116 QKKVSKTRHTRETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSIS 174
Query: 94 GDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKI 149
G G +LF I +TG++ T+ +DREE V+ L A A + G + I++
Sbjct: 175 GRGVDKEPLNLFYIERDTGNLFCTRPVDREEYDVFDLIAYA-STADGYSADLPLPLPIRV 233
Query: 150 HDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP--- 206
D NDN P+FT+ +Y V E S GT V V ATD D+P ++ ++ YSILQ P
Sbjct: 234 EDENDNHPVFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSP 292
Query: 207 -YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265
FSV TG+I T +DRE ++Y ++++ +DM GQ GL GT+T IT+TD NDN
Sbjct: 293 GLFSVHPSTGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNA 352
Query: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADV--GENAEIEYSITDGEGLDMFDVITDQE 323
P F Q+ Y+ E++ I RI D D+ N + ++I G F + TD+E
Sbjct: 353 PTFRQNAYEAFVEENA-FNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKE 411
Query: 324 TQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVF 383
T EG+++V K L++E+ + L++ +N R + + A V + V D+DE P
Sbjct: 412 TNEGVLSVVKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPEC 471
Query: 384 SKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTS 443
+ A ++I+E+ + + I A DP+ RN + D ID +GSI TS
Sbjct: 472 TPAAQYVRIKENLAVGSKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITS 530
Query: 444 KLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEK 499
K+LDRE +NITV+A I+ +S L + + DVNDN PE + Y K
Sbjct: 531 KILDREVETPKNELYNITVLA--IDKDDRSCTGTLAVNIEDVNDNPPEILQEYVVICKPK 588
Query: 500 AKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRH 559
++ AVD D+P G F FSL + S ++TA L+ +
Sbjct: 589 MGYTDIL----AVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQ 644
Query: 560 EMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAI 619
E Y +P+ + D Q++T + V +C C H C A + L A++AI
Sbjct: 645 E---YTIPITVKDR--AGQAATKLLRVNLCECTH---PTQCRATSRSTGVILGKWAILAI 696
Query: 620 LLCIVIL---LVTVV--LFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEE 667
LL I +L L+T+V +F A + +R E L + N++ N E G++
Sbjct: 697 LLGIALLFSVLLTLVCGVFGATKGKRFPEDL------AQQNLIISNTEAPGDD 743
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 235 bits (599), Expect = 1e-61
Identities = 234/812 (28%), Positives = 372/812 (45%), Gaps = 91/812 (11%)
Query: 24 LSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDR 83
LS R + P K+ + + L RSKR W L+E G Q+V ++ SD +
Sbjct: 111 LSARENKSPKKRHTKDTA------LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ 164
Query: 84 GDGSLKYILSGDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPV 139
+ ++ Y +SG G +LF I ++TGDI T+ +DRE+ + L A P
Sbjct: 165 -NYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPE 223
Query: 140 EPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVY 199
P IIKI D NDN P F V TVPE GT V +VTATD D+P ++ ++ Y
Sbjct: 224 YP-LPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKY 281
Query: 200 SILQGQP----YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVN 255
ILQ P +FS+ +TG+I T +DRE + YQ++++ +DMGGQ GL T T+
Sbjct: 282 KILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTIT 341
Query: 256 ITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGE--NAEIEYSITDGEGL 313
I+L D NDNPP F +++Y + E + I R+K D D+ +++ Y I G
Sbjct: 342 ISLEDENDNPPSFTETSYVTEV-EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNEN 400
Query: 314 DMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLG----PFKDSAT 369
F + TD T EG++ V K L++E + L+V N E +F P + T
Sbjct: 401 GNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVIN---EAQFSKAASSQTPTMCTTT 457
Query: 370 VRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPD-AARNPVKYSVDRHTDMD 428
V + + D DE P ++Q ++ + A DP+ ++ ++Y + D D
Sbjct: 458 VTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDED 515
Query: 429 RIFNIDSGNGSIFTSKLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDN 484
F I+ G + T K+LDRE+ +NI+V+A ++ +S L + + D ND+
Sbjct: 516 NWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVA--VDAVGRSCTGTLVVHLDDYNDH 573
Query: 485 APEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKD 544
AP+ + E +C+ ++ L VD D P +G F F L + ++ N+ I++
Sbjct: 574 APQIDK--EVTICQN---NEDFAVLKPVDPDGPENGPPFQFFL--DNSASKNWNIEEKDG 626
Query: 545 NTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACD--HHGNMQSCHA 602
TA + R+N + + Y +P+ I D V +T +TVRVC C M+
Sbjct: 627 KTAILRQRQN----LDYNYYSVPIQIKDRHGLV--ATHMLTVRVCDCSTPSECRMKDKST 680
Query: 603 EALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDI-RDNIVSYND 661
+ L A++A++L V+LL +LF K+ EDI + N++ N
Sbjct: 681 RDVRPNVILGRWAILAMVLGSVLLL--CILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNT 738
Query: 662 EGGGEEDTQA---------------FDIGT--------------LRNPEAIEDNKLRRDI 692
EG GEE T+A +GT ++ ++ NK
Sbjct: 739 EGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQ 798
Query: 693 VPEALFLPRRTPTAR-DNTDVRDFINQRLKE-----NDTDPTAPPYDSLATYAYEGTGSV 746
E++ + T R TD + F RL E + D + +Y YEG GS+
Sbjct: 799 TLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSL 858
Query: 747 ADSLSSLESVTTDADQDYDYLSDWGPRFKKLA 778
A S+ ++ ++L P+F+ LA
Sbjct: 859 AGSVGCCSD--RQEEEGLEFLDHLEPKFRTLA 888
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 231 bits (590), Expect = 2e-60
Identities = 207/670 (30%), Positives = 325/670 (48%), Gaps = 54/670 (8%)
Query: 24 LSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDR 83
LS R + P K+ + + L RSKR W L+E G Q+V ++ SD +
Sbjct: 111 LSARENKSPKKRHTKDTA------LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ 164
Query: 84 GDGSLKYILSGDGAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPV 139
+ ++ Y +SG G +LF I ++TGDI T+ +DRE+ + L A P
Sbjct: 165 -NYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPE 223
Query: 140 EPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVY 199
P IIKI D NDN P F V TVPE GT V +VTATD D+P ++ ++ Y
Sbjct: 224 YP-LPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKY 281
Query: 200 SILQGQP----YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVN 255
ILQ P +FS+ +TG+I T +DRE + YQ++++ +DMGGQ GL T T+
Sbjct: 282 KILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTIT 341
Query: 256 ITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGE--NAEIEYSITDGEGL 313
I+L D NDNPP F +++Y + E + I R+K D D+ +++ Y I G
Sbjct: 342 ISLEDENDNPPSFTETSYVTEV-EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNEN 400
Query: 314 DMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLG----PFKDSAT 369
F + TD T EG++ V K L++E + L+V N E +F P + T
Sbjct: 401 GNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVIN---EAQFSKAASSQTPTMCTTT 457
Query: 370 VRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPD-AARNPVKYSVDRHTDMD 428
V + + D DE P ++Q ++ + A DP+ ++ ++Y + D D
Sbjct: 458 VTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRY--QKLGDED 515
Query: 429 RIFNIDSGNGSIFTSKLLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDN 484
F I+ G + T K+LDRE+ +NI+V+A ++ +S L + + D ND+
Sbjct: 516 NWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVA--VDAVGRSCTGTLVVHLDDYNDH 573
Query: 485 APEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKD 544
AP+ + E +C+ ++ L VD D P +G F F L + ++ N+ I++
Sbjct: 574 APQIDK--EVTICQN---NEDFAVLKPVDPDGPENGPPFQFFL--DNSASKNWNIEEKDG 626
Query: 545 NTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACD--HHGNMQSCHA 602
TA + R+N + + Y +P+ I D V +T +TVRVC C M+
Sbjct: 627 KTAILRQRQN----LDYNYYSVPIQIKDRHGLV--ATHMLTVRVCDCSTPSECRMKDKST 680
Query: 603 EALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDI-RDNIVSYND 661
+ L A++A++L V+LL +LF K+ EDI + N++ N
Sbjct: 681 RDVRPNVILGRWAILAMVLGSVLLL--CILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNT 738
Query: 662 EGGGEEDTQA 671
EG GEE T+A
Sbjct: 739 EGPGEEVTEA 748
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 229 bits (583), Expect = 1e-59
Identities = 225/799 (28%), Positives = 360/799 (45%), Gaps = 75/799 (9%)
Query: 36 RALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGD 95
+ L+ + L R+KR W +LE G ++ ++ SD + + ++ Y + G
Sbjct: 118 KVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGP 176
Query: 96 GAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHD 151
G +LF + +TG++ T+ +DRE+ + + A A P P IIKI D
Sbjct: 177 GVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIED 235
Query: 152 INDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP----Y 207
NDN PIFT+E YT T+ E VGT V QV ATD D+P ++ ++ YSI+ P
Sbjct: 236 ENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTL 294
Query: 208 FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
FS+ TG+I T +DRE ++YQ+ I+ +DM GQ GL T+T I + DVND+ P
Sbjct: 295 FSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT 354
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQ 325
F +++Y + E + I R+ D D+ A Y+I G F ++TD +T
Sbjct: 355 FTRTSY-VTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTN 413
Query: 326 EGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSK 385
EG++ V K L++E+K+ L++ N R +ATV + VED DE P +
Sbjct: 414 EGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNP 473
Query: 386 LAYILQIREDAQINTTIGSVTAQDPDA-ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSK 444
++++E+A++ TT A DP+ + + ++Y + TD ID GSI +
Sbjct: 474 PIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFR 531
Query: 445 LLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKA 500
LDRE +NITV+A++ ++ L I + DVNDN+P F +C+
Sbjct: 532 SLDREAETIKNGIYNITVLASDQGG--RTCTGTLGIILQDVNDNSP-FIPKKTVIICKPT 588
Query: 501 KADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHE 560
+ I AVD D+P G F FSL + ++TA L+ +N
Sbjct: 589 MSSAEIV---AVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PP 642
Query: 561 MSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTG--ALVA 618
+Y++P+ + D SS ++ V +C C N + + I G+ G A++A
Sbjct: 643 FGSYVVPITVRDR--LGMSSVTSLDVTLCDCITE-NDCTHRVDPRIGGGGVQLGKWAILA 699
Query: 619 ILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFD----- 673
ILL I +L + K+P +I + + N++ N E G++ + +
Sbjct: 700 ILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDDKVYSANGFTTQ 759
Query: 674 ---------IGTLRN------PEAIE--------DNKLRRDIVPEALFLPRRTPTARDN- 709
GT+ + E IE R L R T DN
Sbjct: 760 TVGASAQGVCGTVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNC 819
Query: 710 ----TDVRDFINQRLKE-----NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDA 760
++ F RL E N + D + TY YEG GSVA S+
Sbjct: 820 RYTYSEWHSFTQPRLGEKVYLCNQDENHKHAQDYVLTYNYEGRGSVAGSVGCCSE--RQE 877
Query: 761 DQDYDYLSDWGPRFKKLAD 779
+ ++L + P+F+ LA+
Sbjct: 878 EDGLEFLDNLEPKFRTLAE 896
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 225 bits (574), Expect = 1e-58
Identities = 193/649 (29%), Positives = 312/649 (48%), Gaps = 35/649 (5%)
Query: 36 RALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGD 95
+ L+ + L R+KR W +LE G ++ ++ SD + + ++ Y + G
Sbjct: 118 KVLKKRHTKEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGP 176
Query: 96 GAG----DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHD 151
G +LF + +TG++ T+ +DRE+ + + A A P P IIKI D
Sbjct: 177 GVDQEPRNLFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTPELP-LPLIIKIED 235
Query: 152 INDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP----Y 207
NDN PIFT+E YT T+ E VGT V QV ATD D+P ++ ++ YSI+ P
Sbjct: 236 ENDNYPIFTEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTL 294
Query: 208 FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
FS+ TG+I T +DRE ++YQ+ I+ +DM GQ GL T+T I + DVND+ P
Sbjct: 295 FSMHPTTGVITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPT 354
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENA--EIEYSITDGEGLDMFDVITDQETQ 325
F +++Y + E + I R+ D D+ A Y+I G F ++TD +T
Sbjct: 355 FTRTSY-VTSVEENTVDVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTN 413
Query: 326 EGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSK 385
EG++ V K L++E+K+ L++ N R +ATV + VED DE P +
Sbjct: 414 EGVLCVVKPLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNP 473
Query: 386 LAYILQIREDAQINTTIGSVTAQDPDA-ARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSK 444
++++E+A++ TT A DP+ + + ++Y + TD ID GSI +
Sbjct: 474 PIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFR 531
Query: 445 LLDRETLL----WHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKA 500
LDRE +NITV+A++ ++ L I + DVNDN+P F +C+
Sbjct: 532 SLDREAETIKNGIYNITVLASDQGG--RTCTGTLGIILQDVNDNSP-FIPKKTVIICKPT 588
Query: 501 KADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHE 560
+ I AVD D+P G F FSL + ++TA L+ +N
Sbjct: 589 MSSAEIV---AVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PP 642
Query: 561 MSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTG--ALVA 618
+Y++P+ + D SS ++ V +C C N + + I G+ G A++A
Sbjct: 643 FGSYVVPITVRDR--LGMSSVTSLDVTLCDCITE-NDCTHRVDPRIGGGGVQLGKWAILA 699
Query: 619 ILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEE 667
ILL I +L + K+P +I + + N++ N E G++
Sbjct: 700 ILLGIALLFCILFTLVCGASGTSKQPKVIPDDLAQQNLIVSNTEAPGDD 748
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 224 bits (572), Expect = 2e-58
Identities = 170/520 (32%), Positives = 258/520 (49%), Gaps = 36/520 (6%)
Query: 79 SDQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGR 137
+D D G +G L Y +SG F+I+ TG ++ LDRE Y L + G
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYD--LGI 799
Query: 138 PVEPESEFI-IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAK 196
P + + + + D NDN P F +E Y V E +V + ++QV ATD D G +
Sbjct: 800 PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD---LGPNGH 856
Query: 197 VVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNI 256
V YSI+ FS++S TG++ A +DRE + ++ + I+A+D + L T V +
Sbjct: 857 VTYSIVTDTDTFSIDSVTGVVNIAR-PLDRELQHEHSLKIEARDQAREEPQLFSTVVVKV 915
Query: 257 TLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITD-GEGLDM 315
+L DVNDNPP F Y+ K E P GT I ++A D D+G++ ++ YS+ D GEG
Sbjct: 916 SLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEG--N 973
Query: 316 FDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVE 375
FDV + G + + + LDFEKK+VY L V A + P S+T + VE
Sbjct: 974 FDV----DKLSGAVRIVQQLDFEKKQVYNLTVRAKDKG--------KPVSLSSTCYVEVE 1021
Query: 376 DVD-----EPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDR 429
VD PPVFS ++EDA + + + +V+A D DA R+ ++YS+ R
Sbjct: 1022 VVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI-RDGSGVG 1080
Query: 430 IFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFA 489
+F I G I TS LDRE+ + +TV AT+ SS + +YI+V DVNDNAP+ +
Sbjct: 1081 VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTS 1140
Query: 490 E-FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAG 548
E Y + E + D + + A D D + L + SG+ T
Sbjct: 1141 EPVYYPEIMENSPKDVSVVQIEAFDPDSSSND-----KLMYKITSGNPQGFFSIHPKTGL 1195
Query: 549 ILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
I T +R + ++L V ++DN P +S+ V V++
Sbjct: 1196 ITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKI 1235
Score = 211 bits (537), Expect = 2e-54
Identities = 163/504 (32%), Positives = 254/504 (50%), Gaps = 35/504 (6%)
Query: 90 YILSGDGAGDLFIIN-ENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIK 148
+I GD G + +N + K LDRE++ Y+L A T ++ +K
Sbjct: 2957 FITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITA----TDGTFSSKAIVEVK 3012
Query: 149 IHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSIL-QGQPY 207
+ D NDN P+ K +Y+ T+PE G ++Q++ATDAD ++A++ Y++L G
Sbjct: 3013 VLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD---IRSNAEITYTLLGSGAEK 3069
Query: 208 FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
F + +TG +KT+ +DRE + Y ++++A D GG+ S + +TL DVNDN P
Sbjct: 3070 FKLNPDTGELKTST-PLDREEQAVYHLLVRATDGGGRFCQAS----IVLTLEDVNDNAPE 3124
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEG 327
F Y E++ PGT + R++A+DAD G N +I YS+ +D D G
Sbjct: 3125 FSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSL-----IDSADGQFSINELSG 3179
Query: 328 IITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKL 386
II ++K LD E + VYTL ++A + + R G TV + V D+ D PPVF
Sbjct: 3180 IIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATG------TVIVSVLDINDNPPVFEYR 3233
Query: 387 AYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKL 445
Y + ED + T + V A D N + YS+ + + F+IDS G++F +
Sbjct: 3234 EYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGK-FSIDSKTGAVFIIEN 3292
Query: 446 LDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFA-EFYETFVCEKAKADQ 504
LD E+ + +TV AT+ P S + + V D+NDN P F+ + Y T + E A +Q
Sbjct: 3293 LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQ 3352
Query: 505 LIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTY 564
+ T+ A D D P + H +S+ + GS+FTI D G + +R +S Y
Sbjct: 3353 SVITVMADDADGPSNSH-IHYSII-DGNQGSSFTI----DPVRGEVKVTKLLDRETISGY 3406
Query: 565 LLPVVISDNDYPVQSSTGTVTVRV 588
L V SDN P + +T TV + V
Sbjct: 3407 TLTVQASDNGSPPRVNTTTVNIDV 3430
Score = 184 bits (468), Expect = 2e-46
Identities = 157/497 (31%), Positives = 235/497 (47%), Gaps = 36/497 (7%)
Query: 101 FIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFT 160
F+I+ +G ++ K LD E Y A + + + I++ D NDN P+F
Sbjct: 2751 FVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFE 2810
Query: 161 KEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPY-----FSVESETG 215
Y A + E G+ V+Q+ A+DAD T G +V+YS+ Q Q F++ ETG
Sbjct: 2811 SSPYEAFIVENLPGGSRVIQIRASDADSGTNG---QVMYSLDQSQSVEVIESFAINMETG 2867
Query: 216 IIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQF 275
I T L +D E R+ YQ+ + A D G ++ LS T V++T+TDVND+PPRF Y+
Sbjct: 2868 WI-TTLKELDHEKRDNYQIKVVASDHGEKIQ-LSSTAIVDVTVTDVNDSPPRFTAEIYKG 2925
Query: 276 KTPESSPPGTPIGRIKASDADVGE-NAEIEYSITDGEGLDMFDVITDQETQEGIITVKKL 334
E P G I + +DAD E N ++ Y IT G+ L F V T Q E + VKK
Sbjct: 2926 TVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQ--NEWKVYVKKP 2983
Query: 335 LDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQIR 393
LD EK+ Y L + A++ G F A V + V D D PV K Y I
Sbjct: 2984 LDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIP 3033
Query: 394 EDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLW 453
ED I ++A D D N + ++ F ++ G + TS LDRE
Sbjct: 3034 EDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAV 3092
Query: 454 HNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEF-AEFYETFVCEKAKADQLIQTLHAV 512
+++ V AT+ + + + + + DVNDNAPEF A+ Y V E + L+ + A
Sbjct: 3093 YHLLVRATD--GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQAT 3150
Query: 513 DKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISD 572
D D + + +SL A F+I + +GI+ + +R + Y L + D
Sbjct: 3151 DADAGLN-RKILYSLIDSA--DGQFSINE----LSGIIQLEKPLDRELQAVYTLSLKAVD 3203
Query: 573 NDYPVQ-SSTGTVTVRV 588
P + ++TGTV V V
Sbjct: 3204 QGLPRRLTATGTVIVSV 3220
Score = 182 bits (462), Expect = 1e-45
Identities = 152/538 (28%), Positives = 251/538 (46%), Gaps = 59/538 (10%)
Query: 78 HSDQDRGDGSLKY-ILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTG 136
H + R DG ++Y I G G G +F I E TG I+ + RLDRE Y L A T
Sbjct: 1059 HDEDARRDGEIRYSIRDGSGVG-VFKIGEETGVIETSDRLDRESTSHYWLTVFA----TD 1113
Query: 137 RPVEPESEFI---IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGN 193
+ V P S FI I++ D+NDN P ++ VY + E S VVQ+ +A DP +
Sbjct: 1114 QGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI---EAFDPDSSS 1170
Query: 194 SAKVVYSILQGQP--YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGT 251
+ K++Y I G P +FS+ +TG+I T +DRE ++++ + + D G S
Sbjct: 1171 NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSP--PKSTI 1228
Query: 252 TTVNITLTDVNDNPPRFPQSTYQFKTPESSPPG-------TPIGRIKASDADVGENAEIE 304
V + + D NDN P+F Q Y+ + PE P P+ + A+D D G NAEI
Sbjct: 1229 ARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEIS 1288
Query: 305 YSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLK-VEASNPYVEPRFLYLGP 363
YSI DG F + E + G+++ K+ + + ++K V+ P
Sbjct: 1289 YSIEDGNEHGKFFI----EPKTGVVSSKRFSAAGEYDILSIKAVDNGRP----------- 1333
Query: 364 FKDSATVRIVVEDVD------EPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPV 417
+ S+T R+ +E + EP F + + + E + IG ++ + P P+
Sbjct: 1334 -QKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGI---PL 1389
Query: 418 KYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIK 477
+ + + D F++D G G+I +K LD E +N+TV AT+ + ++IK
Sbjct: 1390 WFDI-TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD---GTTTILTQVFIK 1445
Query: 478 VLDVNDNAPEFA-EFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSN 536
V+D ND+ P+F+ YE + E + I + AVD+D+ + ++ + + S
Sbjct: 1446 VIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEK-NKLIYTLQSSRDPLSLKK 1504
Query: 537 FTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHH 594
F + D G L + + + L V++ D D PV+ + + V V + H
Sbjct: 1505 FRL----DPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDH 1558
Score = 182 bits (462), Expect = 1e-45
Identities = 150/501 (29%), Positives = 243/501 (48%), Gaps = 42/501 (8%)
Query: 95 DGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDIND 154
D A F INE +G IQ K LDRE + VY L +A+++ R + I+ + DIND
Sbjct: 3166 DSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDIND 3225
Query: 155 NEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPY--FSVES 212
N P+F Y ATV E VGT V+QV A D +A++ YSI+ G + FS++S
Sbjct: 3226 NPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEA---NAEITYSIISGNEHGKFSIDS 3282
Query: 213 ETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQST 272
+TG + + N+D E+ +Y + ++A D G LS TVN+ +TD+NDN P F Q T
Sbjct: 3283 KTGAV-FIIENLDYESSHEYYLTVEATD--GGTPSLSDVATVNVNVTDINDNTPVFSQDT 3339
Query: 273 YQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVK 332
Y E + + + A DAD N+ I YSI DG F + + G + V
Sbjct: 3340 YTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTI----DPVRGEVKVT 3395
Query: 333 KLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQ 391
KLLD E YTL V+AS+ PR ++ TV I V DV D PVFS+ Y +
Sbjct: 3396 KLLDRETISGYTLTVQASDNGSPPRV-------NTTTVNIDVSDVNDNAPVFSRGNYSVI 3448
Query: 392 IREDAQINTTIGSVTAQDPDAARN--PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRE 449
I+E+ + ++ + D D++ N P +++ D ++ F ++ G + TS + R+
Sbjct: 3449 IQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGND-EKAFEVNP-QGVLLTSSAIKRK 3506
Query: 450 TLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAK--ADQLIQ 507
+ + V + P+ SS + I+V++ + P E F+ + + +I
Sbjct: 3507 EKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPL-EIFITSSGEEYSGGVIG 3565
Query: 508 TLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLP 567
+HA D+D ++SL P+ DN + + + + + ++ YLL
Sbjct: 3566 KIHATDQD---VYDTLTYSLDPQ---------MDNLFSVSSTGGKLIAHKKLDIGQYLLN 3613
Query: 568 VVISDNDYPVQSSTGTVTVRV 588
V ++D + ++ +TV +
Sbjct: 3614 VSVTDGKF---TTVADITVHI 3631
Score = 179 bits (455), Expect = 7e-45
Identities = 152/494 (30%), Positives = 235/494 (47%), Gaps = 33/494 (6%)
Query: 101 FIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFT 160
F IN NTG I LD E P Y L +A + TG E + I+ DINDN P+F
Sbjct: 2227 FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVD--DINDNPPVFA 2284
Query: 161 KEVYTATVPEMSDVGTFVVQVTATDAD-DPTYGNSAKVVYSILQGQPYFSVESETGIIKT 219
++ Y T+ E S +GT VVQV ATD+D +P G S ++ + + +F V+S TG+I +
Sbjct: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLI-S 2343
Query: 220 ALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPE 279
L +D E Q+ + ++A D G M LS V + +TD+NDNPP F Q Y+ + E
Sbjct: 2344 LLRTLDYEQSRQHTIFVRAVD--GGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
Query: 280 SSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEK 339
+P G + +KA DAD + +++YSI G F + ++ GIIT+ L
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVI----DSATGIITLSNLHRHAL 2457
Query: 340 KKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVD-EPPVFSKLAYILQIREDAQI 398
K Y+L + S+ G F+ S V + V + P F + Y +++ E+A +
Sbjct: 2458 KPFYSLNLSVSD----------GVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPL 2507
Query: 399 NTTIGSVTAQDPDAA-RNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNIT 457
+T + V D D+ V Y + DR + + G IFT + LDRET I+
Sbjct: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFY--INERGQIFTLEKLDRETPAEKVIS 2565
Query: 458 VIATEINNPKQSSRVPLYIKVLDVNDNAPEF-AEFYETFVCEKAKADQLIQTLHAVDKDD 516
V + + + + + + D NDNAP+F A YE + A + + A D D+
Sbjct: 2566 VRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADE 2625
Query: 517 PYSGHQFSFSLAPEAASGSNFTIQDNKD--NTAGILTRKNGYNRHEMSTYLLPVVISDND 574
G + A EA S S +++N + +G++T K E + V DN
Sbjct: 2626 ---GSNADITYAIEADSES---VKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNG 2679
Query: 575 YPVQSSTGTVTVRV 588
P + S V V++
Sbjct: 2680 SPSKESVVLVYVKI 2693
Score = 167 bits (424), Expect = 3e-41
Identities = 152/519 (29%), Positives = 250/519 (48%), Gaps = 43/519 (8%)
Query: 79 SDQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGR 137
+D+D G +G + Y + D D F I+ TG + + LDRE + + L+ +A ++
Sbjct: 847 TDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREE 904
Query: 138 PVEPESEFIIKI--HDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSA 195
P + S ++K+ D+NDN P F Y V E GT ++ + +A DP G S
Sbjct: 905 P-QLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWL---EAHDPDLGQSG 960
Query: 196 KVVYSILQ-GQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTV 254
+V YS+L G+ F V+ +G ++ + +D E ++ Y + ++AKD G + LS T V
Sbjct: 961 QVRYSLLDHGEGNFDVDKLSGAVRI-VQQLDFEKKQVYNLTVRAKDKGKPVS-LSSTCYV 1018
Query: 255 NITLTDVNDN--PPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEG 312
+ + DVN+N PP F + E +P G+ + + A D D + EI YSI DG G
Sbjct: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSG 1078
Query: 313 LDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRI 372
+ +F + +ET G+I LD E Y L V A++ V P ++ + I
Sbjct: 1079 VGVFKI--GEET--GVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFI-------EIYI 1127
Query: 373 VVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIF 431
VEDV D P S+ Y +I E++ + ++ + A DPD++ N + F
Sbjct: 1128 EVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFF 1187
Query: 432 NIDSGNGSIFT-SKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE 490
+I G I T S+ LDRE H + V T+ +P +S+ + +K+LD NDN P+F +
Sbjct: 1188 SIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQ 1247
Query: 491 -FYETFVCEKAKAD-------QLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDN 542
FY+ + E+ K D + + + A DKD+ + + S+S+ G F
Sbjct: 1248 KFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA-EISYSIEDGNEHGKFFI---- 1302
Query: 543 KDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSST 581
+ G+++ K E +L + DN P +SST
Sbjct: 1303 -EPKTGVVSSKRFSAAGEYD--ILSIKAVDNGRPQKSST 1338
Score = 146 bits (369), Expect = 6e-35
Identities = 133/514 (25%), Positives = 227/514 (44%), Gaps = 51/514 (9%)
Query: 87 SLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFI 146
S+ Y + GD F IN ++G I K LD E P+Y L Q N + + +
Sbjct: 1696 SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAG---LSTNTTVL 1752
Query: 147 IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQ-------VTATDADDPTYGNSAKVVY 199
+ + D NDN P+F + YT + E + + + V+ + A DAD + +A +VY
Sbjct: 1753 VHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS---NALLVY 1809
Query: 200 SILQGQ--PYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 257
I++ YF+++S TG I T +L++D E + +Q DMG V +
Sbjct: 1810 HIVEPSVHTYFAIDSSTGAIHT-VLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868
Query: 258 LTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFD 317
+ D+ND PP F + Y+ + G + + A+DAD +++ YSIT+G + F
Sbjct: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
Query: 318 VITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV 377
+ + + G +TV+ + Y L V AS+ G F +V+I V++
Sbjct: 1929 M----DYKTGALTVQNTTQLRSR--YELTVRASD----------GRFAGLTSVKINVKES 1972
Query: 378 DEPPV-FSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRH-TDMDRIFNIDS 435
E + F++ Y ++E++ T+ +T A NP+ + H + DR F I
Sbjct: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVIT-----AIGNPINEPLFYHILNPDRRFKISR 2027
Query: 436 GNGSIFTSKL-LDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF-YE 493
+G + T+ DRE ++ V TE + P + V + + V D NDNAP F Y
Sbjct: 2028 TSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYY 2087
Query: 494 TFVCEKAKADQLIQTLHAVDKDDPYSG--------HQFSFSLAP--EAASGSNFTIQDNK 543
V + +I+ + AVD+D +G H F + P E + F +
Sbjct: 2088 AVVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISLKKQFELDTLN 2147
Query: 544 DNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPV 577
+ K+G N + ++P+ + + PV
Sbjct: 2148 KEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPV 2181
Score = 139 bits (351), Expect = 8e-33
Identities = 137/521 (26%), Positives = 223/521 (42%), Gaps = 40/521 (7%)
Query: 80 DQDRGD-GSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138
D D D L+Y + F+I+ TG I + KP Y L +
Sbjct: 2416 DADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSV----SDGV 2471
Query: 139 VEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVV 198
++ + + N + P F + Y + E + + T V++V TD D YG+ V
Sbjct: 2472 FRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH---VT 2528
Query: 199 YSILQ--GQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNI 256
Y I+ + F + I L+ + + V + AKD GG++ TVN+
Sbjct: 2529 YHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVA----FCTVNV 2584
Query: 257 TLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMF 316
LTD NDN P+F + Y+ S+ GT + ++ ASDAD G NA+I Y+I D
Sbjct: 2585 ILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIE----ADSE 2640
Query: 317 DVITDQETQE--GIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSAT---VR 371
V + E + G+IT K+ L + + +T V A + P K+S V+
Sbjct: 2641 SVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNG--------SPSKESVVLVYVK 2692
Query: 372 IVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIF 431
I+ ++ + P FS+ Y + ED I T I + A+ + ++ D F
Sbjct: 2693 ILPPEM-QLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESF 2751
Query: 432 NIDSGNGSIFTSKLLDRETLLWHNITVIA-TEINNPKQSSRVPLYIKVLDVNDNAPEF-A 489
ID +G + K LD ET W+ +++A ++ + + V + I+V D NDN+P F +
Sbjct: 2752 VIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFES 2811
Query: 490 EFYETFVCEKAKADQLIQTLHAVDKDDPYSGH-QFSFSLAPEAASGSNFTIQDNKDNTAG 548
YE F+ E + + A D D +G +S + +F I + G
Sbjct: 2812 SPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAI----NMETG 2867
Query: 549 ILTRKNGYNRHEMSTYLLPVVISDNDYPVQ-SSTGTVTVRV 588
+T + + Y + VV SD+ +Q SST V V V
Sbjct: 2868 WITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908
Score = 134 bits (338), Expect = 3e-31
Identities = 116/428 (27%), Positives = 200/428 (46%), Gaps = 37/428 (8%)
Query: 88 LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFII 147
L + ++G F +++ TG I K LD E+K Y L +A + T ++ I
Sbjct: 1389 LWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFI 1444
Query: 148 KIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP- 206
K+ D ND+ P F+ Y +PE + T ++Q++A D D+ K++Y++ +
Sbjct: 1445 KVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN-----KLIYTLQSSRDP 1499
Query: 207 ----YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVN 262
F ++ TG + T+ +D E Q+ + + +D + VN++ D N
Sbjct: 1500 LSLKKFRLDPATGSLYTSE-KLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVS--DTN 1556
Query: 263 DNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQ 322
D+ P F S+Y+ + ES+ G+ + ++ A D D G+NAE+ YSI G + F +
Sbjct: 1557 DHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMI---- 1612
Query: 323 ETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDE-PP 381
+ G I K LD + Y L V+A++ P + +VRI V D P
Sbjct: 1613 DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSP-------PMSEITSVRIFVTIADNASP 1665
Query: 382 VFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIF 441
F+ Y +++ E I + +G VTA +++ V Y + D F+I+ +G+I
Sbjct: 1666 KFTSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYEIKDGNTGD-AFDINPHSGTII 1720
Query: 442 TSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF-YETFVCEKA 500
T K LD ETL + + + T N S+ + + + D NDNAP F + Y + E A
Sbjct: 1721 TQKALDFETLPIYTLIIQGT--NMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESA 1778
Query: 501 KADQLIQT 508
+ ++ T
Sbjct: 1779 SINSVVLT 1786
Score = 121 bits (304), Expect = 2e-27
Identities = 107/389 (27%), Positives = 181/389 (46%), Gaps = 38/389 (9%)
Query: 143 SEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSIL 202
+E I+ I +N P+F K Y+A + E V + VV V A + KV YSI
Sbjct: 2166 AEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE------GLKVFYSIT 2219
Query: 203 QGQPY--FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTD 260
G P+ F++ TG+I + +D E Y++ I+A D + G V+I + D
Sbjct: 2220 DGDPFSQFTINFNTGVI-NVIAPLDFEAHPAYKLSIRATD---SLTGAHAEVFVDIIVDD 2275
Query: 261 VNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSI--TDGEGLDMFDV 318
+NDNPP F Q +Y E+S GT + +++A+D+D N I Y + + D F V
Sbjct: 2276 INDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHV 2335
Query: 319 ITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV- 377
++ G+I++ + LD+E+ + +T+ V A + G ++ IV DV
Sbjct: 2336 ----DSSTGLISLLRTLDYEQSRQHTIFVRAVD----------GGMPTLSSDVIVTVDVT 2381
Query: 378 ---DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAAR-NPVKYSVDRHTDMDRIFNI 433
D PP+F + Y +I E A + V A D D++ + ++YS+ D + F I
Sbjct: 2382 DLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGND-HKHFVI 2440
Query: 434 DSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE-FY 492
DS G I S L ++++ + +++ S +++ V+ N ++P F + Y
Sbjct: 2441 DSATGIITLSNLHRHALKPFYSLNL---SVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEY 2497
Query: 493 ETFVCEKAKADQLIQTLHAVDKDDPYSGH 521
E + E A L+ + D D GH
Sbjct: 2498 EVELAENAPLHTLVMEVKTTDGDSGIYGH 2526
Score = 114 bits (286), Expect = 3e-25
Identities = 134/552 (24%), Positives = 231/552 (41%), Gaps = 69/552 (12%)
Query: 88 LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFII 147
L+Y+ F +N NTG I + + R++ + L +R+ V ++
Sbjct: 398 LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDRKASTKV------LV 451
Query: 148 KIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQ-GQP 206
K+ N N P FT+ Y A E +GT V+ ++A D D+ G + V YSI
Sbjct: 452 KVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDE---GENGYVTYSIANLNHV 508
Query: 207 YFSVESETGIIKTALLNMDRENREQ-YQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265
F+++ TG + T+ N+D E + Y + I+A D G ITL ++NDN
Sbjct: 509 PFAIDHFTGAVSTS-ENLDYELMPRVYTLRIRASDWGLPY-RREVEVLATITLNNLNDNT 566
Query: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQ 325
P F + + P G I + A DAD E ++Y I G LD F +
Sbjct: 567 PLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNELDFFSL----NPN 620
Query: 326 EGIITVKK-LLDFEKKKV--YTLKVEASN--PYVEPRFLYLGPFKDSATVRI-------- 372
G++++K+ L+D KV ++L++ A++ + P ++ + V +
Sbjct: 621 SGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVA 680
Query: 373 -----------------VVEDV---------DEPPVFSKLAYILQIREDAQINTTIGSVT 406
VED+ P S L +Q++E+ + +++ +
Sbjct: 681 KMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMN 740
Query: 407 AQDPDAARN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINN 465
+ D D N + Y+V + D F ID G + LDRET + + + ++
Sbjct: 741 STDLDTGFNGKLVYAVSGGNE-DSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGI 799
Query: 466 PKQSSRVPLYIKVLDVNDNAPEF-AEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFS 524
P++++ L++ V+D NDN PEF E Y V E + I + A DKD +GH +
Sbjct: 800 PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGH-VT 858
Query: 525 FSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTV 584
+S+ + F+I D+ G++ +R + L + D TV
Sbjct: 859 YSIVTDT---DTFSI----DSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTV 911
Query: 585 TVRVCACDHHGN 596
V+V D + N
Sbjct: 912 VVKVSLEDVNDN 923
Score = 114 bits (284), Expect = 5e-25
Identities = 149/542 (27%), Positives = 231/542 (42%), Gaps = 83/542 (15%)
Query: 101 FIINENTGDIQATKRLDREEKP-VYILRAQAINRRTGRPVEPESEFI--IKIHDINDNEP 157
F I+ TG + ++ LD E P VY LR +A + G P E E + I ++++NDN P
Sbjct: 510 FAIDHFTGAVSTSENLDYELMPRVYTLRIRASD--WGLPYRREVEVLATITLNNLNDNTP 567
Query: 158 IFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP--YFSVESETG 215
+F K T+P VG + V+A DAD+ V Y I G +FS+ +G
Sbjct: 568 LFEKINCEGTIPRDLGVGEQITTVSAIDADELQL-----VQYQIEAGNELDFFSLNPNSG 622
Query: 216 II--KTALLN---------------MDREN------------REQYQVVIQAKDMGG--- 243
++ K +L++ D EN V +Q ++ G
Sbjct: 623 VLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKM 682
Query: 244 ------QMGGLSGTTTVNITLTD---VNDNPPRFPQSTYQ--FKTPESSPPGTPIGRIKA 292
Q L V D VN + P+F +ST + E+ P G+ + + +
Sbjct: 683 LAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQF-RSTLPTGIQVKENQPVGSSVIFMNS 741
Query: 293 SDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNP 352
+D D G N ++ Y+++ G F + D ET G++ + LD E YTL + +
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCF--MIDMET--GMLKILSPLDRETTDKYTLNITVYDL 797
Query: 353 YVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPD 411
+ + + + +VV D D PP F + +Y +++ ED ++++ I V A D D
Sbjct: 798 GIPQKAAW-------RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD 850
Query: 412 AARN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATE--INNPKQ 468
N V YS+ TD F+IDS G + ++ LDRE H++ + A + P+
Sbjct: 851 LGPNGHVTYSIVTDTD---TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQL 907
Query: 469 SSRVPLYIKVLDVNDNAPEF-AEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSL 527
S V + + + DVNDN P F Y V E +I L A D D SG Q +SL
Sbjct: 908 FSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSG-QVRYSL 966
Query: 528 APEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQ-SSTGTVTV 586
NF + D +G + + + Y L V D PV SST V V
Sbjct: 967 LDHGE--GNFDV----DKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEV 1020
Query: 587 RV 588
V
Sbjct: 1021 EV 1022
Score = 93.6 bits (231), Expect = 6e-19
Identities = 100/421 (23%), Positives = 180/421 (42%), Gaps = 27/421 (6%)
Query: 113 TKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMS 172
T L+RE K Y L +A+ + T VE ++ +++ D ND P+F+ Y+ ++PE +
Sbjct: 105 TAILNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENT 162
Query: 173 DVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQY 232
+ T + +V+ATDAD G + + YS F++ +G+I +D + Y
Sbjct: 163 AIRTSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVI-VLTGRLDYLETKLY 218
Query: 233 QVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKA 292
++ I A D G ++ G SG +++ + P T +P +
Sbjct: 219 EMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDPAYAIVTV 278
Query: 293 SDADVGENAEI-EYSITDGEGLDMFDVITD-QETQEGIITVKKLLDFEKKKV-YTLKVEA 349
D D G N +I SI G+ L F + ++E + +D++ Y L ++A
Sbjct: 279 DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA 338
Query: 350 SNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPV-FSKLAYILQIREDAQINTTIGSVTAQ 408
+ P+ F + + PV F K Y +I E A NT + V A
Sbjct: 339 KDKGTPPQ------FSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKA- 391
Query: 409 DPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ 468
A + ++Y V + T F+++ G I + + R+ + E+ +
Sbjct: 392 --IPAYSHLRY-VFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFEL-----EVTTSDR 443
Query: 469 SSRVPLYIKVLDVNDNAPEFAE-FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSL 527
+ + +KVL N N PEF + Y+ E + +L AVD D+ +G+ ++S+
Sbjct: 444 KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY-VTYSI 502
Query: 528 A 528
A
Sbjct: 503 A 503
Score = 90.5 bits (223), Expect = 5e-18
Identities = 94/356 (26%), Positives = 165/356 (46%), Gaps = 40/356 (11%)
Query: 159 FTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIK 218
F K+VY A + E + T VV V A P Y + + V+ G+ FS+ TG+I
Sbjct: 367 FEKDVYRAEISEFAPPNTPVVMVKAI----PAYSH-LRYVFKSTPGKAKFSLNYNTGLI- 420
Query: 219 TALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTP 278
+ L + R+ +++ + D +T V + + N NPP F Q+ Y+
Sbjct: 421 SILEPVKRQQAAHFELEVTTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFD 473
Query: 279 ESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFE 338
E+ P GT + + A D D GEN + YSI + L+ D T G ++ + LD+E
Sbjct: 474 ENVPIGTTVMSLSAVDPDEGENGYVTYSIAN---LNHVPFAIDHFT--GAVSTSENLDYE 528
Query: 339 -KKKVYTLKVEASNPYVEPRFLYLGPFKDSATV--RIVVEDV-DEPPVFSKLAYILQIRE 394
+VYTL++ AS+ + P++ V I + ++ D P+F K+ I
Sbjct: 529 LMPRVYTLRIRASD--------WGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPR 580
Query: 395 DAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSK-LLD--RETL 451
D + I +V+A D D + V+Y ++ ++D F+++ +G + + L+D +
Sbjct: 581 DLGVGEQITTVSAIDADELQ-LVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKV 638
Query: 452 LWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQ 507
+H++ + AT+ N PLYI + + + ET V K A++L+Q
Sbjct: 639 SFHSLRITATDGEN----FATPLYINITVAASHKLVNLQCEETGVA-KMLAEKLLQ 689
Score = 88.2 bits (217), Expect = 3e-17
Identities = 105/433 (24%), Positives = 189/433 (43%), Gaps = 42/433 (9%)
Query: 99 DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRT----GRPVEPESEFIIKIHDIND 154
D+F I+ +G I T RLD E +Y + A +R + ++ + I N+
Sbjct: 193 DMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANE 252
Query: 155 NEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQG---QPYFSVE 211
P+ T T + E+ + + VT D D G+ A + SI+ G Q + +V
Sbjct: 253 CAPVIT--AVTLSPSELDRDPAYAI-VTVDDCDQGANGDIASL--SIVAGDLLQQFRTVR 307
Query: 212 SETGIIK---TALLNMDRENRE-QYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
S G + A+ +D ++ Y + +QAKD G S +++T P +
Sbjct: 308 SFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDK-GTPPQFSSVKVIHVTSPQFKAGPVK 366
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEG 327
F + Y+ + E +PP TP+ +KA A + + Y G F + G
Sbjct: 367 FEKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTPGKAKFSL----NYNTG 418
Query: 328 IITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLA 387
+I++ + + ++ + L+V S+ + L V+++ + PP F++ A
Sbjct: 419 LISILEPVKRQQAAHFELEVTTSDRKASTKVL----------VKVLGAN-SNPPEFTQTA 467
Query: 388 YILQIREDAQINTTIGSVTAQDPDAARNP-VKYSVDRHTDMDRIFNIDSGNGSIFTSKLL 446
Y E+ I TT+ S++A DPD N V YS+ + F ID G++ TS+ L
Sbjct: 468 YKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVP--FAIDHFTGAVSTSENL 525
Query: 447 DRETL-LWHNITVIATEINNP-KQSSRVPLYIKVLDVNDNAPEFAEF-YETFVCEKAKAD 503
D E + + + + A++ P ++ V I + ++NDN P F + E +
Sbjct: 526 DYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVG 585
Query: 504 QLIQTLHAVDKDD 516
+ I T+ A+D D+
Sbjct: 586 EQITTVSAIDADE 598
Score = 73.2 bits (178), Expect = 9e-13
Identities = 67/249 (26%), Positives = 116/249 (46%), Gaps = 15/249 (6%)
Query: 88 LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFI- 146
+ Y + G F I+ G+++ TK LDRE Y L QA + G P + +
Sbjct: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD--NGSPPRVNTTTVN 3427
Query: 147 IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP 206
I + D+NDN P+F++ Y+ + E VG V+Q+ TD D + N ++I+ G
Sbjct: 3428 IDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDED--SSHNGPPFFFTIVTGND 3485
Query: 207 YFSVE-SETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265
+ E + G++ T+ + R+ ++ Y + ++ D G LS T ++I + + + P
Sbjct: 3486 EKAFEVNPQGVLLTSSA-IKRKEKDHYLLQVKVADNGKPQ--LSSLTYIDIRVIEESIYP 3542
Query: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQ 325
P + G IG+I A+D DV + + YS+ D + ++F V T
Sbjct: 3543 PAILPLEIFITSSGEEYSGGVIGKIHATDQDVYDT--LTYSL-DPQMDNLFSV---SSTG 3596
Query: 326 EGIITVKKL 334
+I KKL
Sbjct: 3597 GKLIAHKKL 3605
Score = 69.7 bits (169), Expect = 1e-11
Identities = 80/305 (26%), Positives = 131/305 (42%), Gaps = 51/305 (16%)
Query: 159 FTKEVYTATVPEMSDVGTFVVQVTATDA--DDPTYGNSAKVVYSILQGQPYFSVESETGI 216
FT Y TV E S T+V P + +V Y I+ G ++E I
Sbjct: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAW----EVRYKIVSGDSENLFKAEEYI 89
Query: 217 I-------------KTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVND 263
+ TA+LN RE ++ Y ++++A + + T V + + D ND
Sbjct: 90 LGDFCFLRIRTKGGNTAILN--REVKDHYTLIVKALEKNTNV---EARTKVRVQVLDTND 144
Query: 264 NPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQE 323
P F ++Y PE++ T I R+ A+DAD+G N E YS D DMF +
Sbjct: 145 LRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKD--RTDMFAI----H 198
Query: 324 TQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVF 383
G+I + LD+ + K+Y +++ A++ ++ LY G S+ ++ V
Sbjct: 199 PTSGVIVLTGRLDYLETKLYEMEILAADRGMK---LY-GSSGISSMAKLTV--------- 245
Query: 384 SKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTS 443
+I Q E A + I +VT + R+P Y++ D D+ N D + SI
Sbjct: 246 ----HIEQANECAPV---ITAVTLSPSELDRDPA-YAIVTVDDCDQGANGDIASLSIVAG 297
Query: 444 KLLDR 448
LL +
Sbjct: 298 DLLQQ 302
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 217 bits (553), Expect = 3e-56
Identities = 183/564 (32%), Positives = 285/564 (50%), Gaps = 38/564 (6%)
Query: 50 RSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGD----LFIINE 105
R KRS + + + E + VGK+ D DR + S K+ L+G G +F INE
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERS-KFRLTGKGVDQEPKGIFRINE 192
Query: 106 NTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYT 165
NTG + T+ LDRE VY L + + G+ +E + + D NDN PIF + Y
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTDVN-GKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 166 ATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP------YFSVESETG---- 215
V E S GT V+++TA DADDP N A + Y+I Q P F ++ E G
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDN-ALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 216 IIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQF 275
++ ALL+ + +Y+++I+A+DM G GL+GT T I + D ND+ P+F + +Q
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQ- 369
Query: 276 KTPESSPPGTPIGRIKASDADVGENA-EIEYSITDGEGLDMFDVITDQETQEGIITVKKL 334
T E G + D A Y+I +G F++ T+ +T EG+++V K
Sbjct: 370 ATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKP 429
Query: 335 LDFEKKKVYTL--KVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQI 392
LD+E +TL KVE +P V P Y GP +ATV I V DV+E PVF ++
Sbjct: 430 LDYEISAFHTLLIKVENEDPLV-PDVSY-GP-SSTATVHITVLDVNEGPVFYPDPMMVTR 486
Query: 393 REDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETL 451
+ED + + + +V A DPD+ ++ ++YSV + D NI+ NG++ T+ +LDRE+
Sbjct: 487 QEDLSVGSVLLTVNATDPDSLQHQTIRYSV--YKDPAGWLNINPINGTVDTTAVLDRESP 544
Query: 452 LWHN----ITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQ 507
N +A + NP + L I + DVNDNAP F VC+ AK + +
Sbjct: 545 FVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVCDDAK-NLSVV 602
Query: 508 TLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLP 567
L A DKD + F F + +A + I +NT +++ N+ + Y LP
Sbjct: 603 ILGASDKDLHPNTDPFKFEIHKQAVPDKVWKI-SKINNTHALVSLLQNLNK---ANYNLP 658
Query: 568 VVISDNDYPVQSSTGTVTVRVCAC 591
++++D+ P ++ + V+VC+C
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSC 682
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 211 bits (537), Expect = 2e-54
Identities = 156/510 (30%), Positives = 250/510 (49%), Gaps = 32/510 (6%)
Query: 85 DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAIN----RRTGRPVE 140
+G +KY +S +F IN +TG + K LD E + + AI+ RTG
Sbjct: 3121 NGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGY--- 3177
Query: 141 PESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYS 200
+ + D+NDN P+F + Y TV E + GT V+ + ATDAD G +A + Y+
Sbjct: 3178 --CSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADS---GTNAVIAYT 3232
Query: 201 ILQGQP-YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLT 259
+ F ++ TG+I T +D E ++ Y + ++A ++ + TVNI L
Sbjct: 3233 VQSSDSDLFVIDPNTGVITTQGF-LDFETKQSYHLTVKAFNVPDEER--CSFATVNIQLK 3289
Query: 260 DVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVI 319
N+ PRF Y F+ E++P GT +G + ASD D+G + E+ Y I F +
Sbjct: 3290 GTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI- 3348
Query: 320 TDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDE 379
+ G I V +LD EK++ +LKV A N + R G D TV + V D ++
Sbjct: 3349 ---NKKTGQIYVSGILDREKEERVSLKVLAKN-FGSIR----GADIDEVTVNVTVLDAND 3400
Query: 380 PPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDR-IFNIDSGNG 438
PP+F+ Y +QI E I T + V+A D D+ + ++S + + F+I+ G
Sbjct: 3401 PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTG 3460
Query: 439 SIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCE 498
I + LDRETL +N++V+A + P + L + + D+NDN P E V E
Sbjct: 3461 QITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP-MLTVSEGEVME 3519
Query: 499 KAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNR 558
+ L+ TL + D D P + F++ L + S F++ +TAG+L+ +R
Sbjct: 3520 NKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-----STAGVLSTTREIDR 3574
Query: 559 HEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+++ + L VV D+ P SSTGTV + V
Sbjct: 3575 EQIADFYLSVVTKDSGVPQMSSTGTVHITV 3604
Score = 198 bits (504), Expect = 1e-50
Identities = 155/499 (31%), Positives = 243/499 (48%), Gaps = 40/499 (8%)
Query: 98 GDLFIINENTGDIQATKRLDREEKP-VYILRAQAINRRTGRPVEPESEFIIKIHDINDNE 156
G LF I +TG IQ LDRE+ +Y++ AI + T P +E I + DINDN
Sbjct: 1678 GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 157 PIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQG-QPYFSVESETG 215
P+F ++ TV E G+ ++Q+TA DAD+ G +A V Y+I+ G F ++ E+G
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADE---GANALVTYTIISGADDSFRIDPESG 1794
Query: 216 IIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQF 275
+ A +DRE R +Y ++++A D G S +NIT++DVND+ P+F + Y F
Sbjct: 1795 DL-IATRRLDRERRSKYSLLVRADD-----GLQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 276 KTPESSPPGTPIGRIKASDADVGENAEIEYSIT--DGEGLDMFDVITDQETQEGIITVKK 333
PE + PG+ + I A+D D G N EI Y + D +G+ + IT G+ + +
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPIT------GVFNLTR 1902
Query: 334 LLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIR 393
LLD+E ++ Y L V A + G F +++ D PP+FS +Y +
Sbjct: 1903 LLDYEVQQYYILTVRAEDGG--------GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLM 1954
Query: 394 EDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLL 452
E+ + +T+ D D N + YS+ + + F +D NG + K LDRE+
Sbjct: 1955 ENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ-FTVDK-NGVLKVLKALDRESQS 2012
Query: 453 WHNITVIA---TEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTL 509
++N+ V +I + +S + I +LDVNDN P F T++ E D ++
Sbjct: 2013 FYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKA 2072
Query: 510 HAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVV 569
A D D + + L P G+ F+I G + +R E+S Y L VV
Sbjct: 2073 QATDPDSGPNSYIEYTLLNP---LGNKFSI----GTIDGEVRLTGELDREEVSNYTLTVV 2125
Query: 570 ISDNDYPVQSSTGTVTVRV 588
+D P SS+ V V V
Sbjct: 2126 ATDKGQPSLSSSTEVVVMV 2144
Score = 196 bits (497), Expect = 9e-50
Identities = 157/531 (29%), Positives = 253/531 (47%), Gaps = 39/531 (7%)
Query: 63 LEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKP 122
+EE G + + D D G +L GA D F I+ +GD+ AT+RLDRE +
Sbjct: 1749 VEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRS 1808
Query: 123 VYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVT 182
Y L +A + + I + D+ND+ P F++ VY+ +PE + G+ V +
Sbjct: 1809 KYSLLVRADDGLQ----SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAIL 1864
Query: 183 ATDADDPTYGNSAKVVYSILQGQP--YFSVESETGIIKTALLNMDRENREQYQVVIQAKD 240
ATD D G + ++ Y + + F + TG+ L +D E ++ Y + ++A+D
Sbjct: 1865 ATDDDS---GVNGEITYIVNEDDEDGIFFLNPITGVFNLTRL-LDYEVQQYYILTVRAED 1920
Query: 241 MGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGEN 300
GGQ T V + DVNDNPP F ++Y E+ P G+ + +DAD G N
Sbjct: 1921 GGGQF----TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGIN 1976
Query: 301 AEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLY 360
+++ YSI G+ L F V + G++ V K LD E + Y L V+ + P
Sbjct: 1977 SQLTYSIASGDSLGQFTV-----DKNGVLKVLKALDRESQSFYNLVVQVHDLPQIP---- 2027
Query: 361 LGPFKDSATVRIVVEDV-DEPPVF--SKLAYILQIREDAQINTTIGSVTAQDPDAARNP- 416
F +A V I++ DV D PP F KL Y I E+ I+T + A DPD+ N
Sbjct: 2028 ASRFTSTAQVSIILLDVNDNPPTFLSPKLTY---IPENTPIDTVVFKAQATDPDSGPNSY 2084
Query: 417 VKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYI 476
++Y++ + F+I + +G + + LDRE + + +TV+AT+ P SS + +
Sbjct: 2085 IEYTL--LNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVV 2142
Query: 477 KVLDVNDNAPEFAE-FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGS 535
VLD+NDN P FA+ Y+ + E I + A D D+ +G Q + +
Sbjct: 2143 MVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNG-QVRYGIV-----NG 2196
Query: 536 NFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTV 586
N + D+ G +T +R + TY L V +D ++ T TV++
Sbjct: 2197 NTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247
Score = 192 bits (489), Expect = 8e-49
Identities = 161/537 (29%), Positives = 251/537 (46%), Gaps = 55/537 (10%)
Query: 79 SDQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRR--- 134
+D D G + ++Y L +G F ++ TG I + LD E + Y L QA++R
Sbjct: 275 ADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS 332
Query: 135 -TGRPVEPESEFIIKIHDINDNEPIFTKEVYTAT-----VPEMSDVGTFVVQVTATDADD 188
TGR +E +I++ D+NDN+P+ + AT V E + VGT V +T TDAD
Sbjct: 333 LTGR-----AEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADS 387
Query: 189 PTYGNSAKVVYSILQG--QPYFSVESET----GIIKTALLNMDRENREQYQVVIQAKDMG 242
P + V IL G Q +F V+S +IK A +DRE Y + + D
Sbjct: 388 PAANGNISV--QILGGNEQRHFEVQSSKVPNLSLIKVASA-LDRERIPSYNLTVSVSDNY 444
Query: 243 GQMGGL-----SGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADV 297
G G S ++ I + D+ND+PP F Q Y+ E +PPG+ + I A+D D
Sbjct: 445 GAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS 504
Query: 298 GENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKL--LDFEKKKVYTLKVEASNPYVE 355
G NA + YSI G GL F + G++T LD E L + A + V
Sbjct: 505 GLNANLRYSIVSGNGLGWFHI----SEHSGLVTTGSSGGLDRELASQIVLNISARDQGVH 560
Query: 356 PRFLYLGPFKDSATVRIVVEDV-DEPPVFSK-LAYILQIREDAQINTTIGSVTAQDPDAA 413
P+ Y A + + + DV DE PVFS+ Y + + E+A T + + A D D
Sbjct: 561 PKVSY-------AQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG 613
Query: 414 RN-PVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRV 472
N V++S+ R F +D +G + T LDRE ++++ V+AT++ +P QSS
Sbjct: 614 DNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMA 673
Query: 473 PLYIKVLDVNDNAPEFAEF-YETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEA 531
+ + +LD+NDN+P F Y + E I T+ A D D G + + A
Sbjct: 674 RINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPD---LGTNGTVKYSISA 730
Query: 532 ASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
S F + + +G+++ + +R E + Y L +V +D + VT+ V
Sbjct: 731 GDRSRFQV----NAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITV 783
Score = 185 bits (469), Expect = 2e-46
Identities = 157/567 (27%), Positives = 259/567 (45%), Gaps = 45/567 (7%)
Query: 79 SDQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGR 137
SD+D G +G + Y ++ GD F I + G + LDRE + Y+L A +R
Sbjct: 1021 SDKDSGANGEIAYTIAEGNTGDAFGIFPD-GQLYIKSELDRELQDRYVLMVVASDRAV-E 1078
Query: 138 PVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKV 197
P+ + + D+NDN P+F YT E G+FV +V+A D D +G + +V
Sbjct: 1079 PLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKD---FGPNGEV 1135
Query: 198 VYSILQGQPYFSVESETGIIKTALLNMDRENREQ------YQVVIQAKDMGGQMGGLSGT 251
YS QP F + + +G I T DRE+ + + + A D G L
Sbjct: 1136 RYSFEMVQPDFELHAISGEI-TNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQP-LKDQ 1193
Query: 252 TTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGE 311
TV++ + D+NDN P+F + YQ ES+ T + R+ ASD D G N I YSI G
Sbjct: 1194 ATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253
Query: 312 GLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVR 371
F + ++ G +T+ LD+E Y+L ++A + P + T+
Sbjct: 1254 EERQFAI----DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIP-------LNSTCTLN 1302
Query: 372 I-VVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRI 430
I ++++ D P F K + + E+ +I + SVTA D D+ N Y T+
Sbjct: 1303 IDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGT 1362
Query: 431 FNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEF-- 488
F+I GSIF +K LD ET + + + A + P +SS + + I V D NDN P F
Sbjct: 1363 FSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPP 1422
Query: 489 AEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAG 548
+ +++ V E + ++ A D D +G Q S+++ + G++FTI D G
Sbjct: 1423 GDIFKSIV-ENIPIGTSVISVTAHDPDADING-QLSYTIIQQMPRGNHFTI----DEVKG 1476
Query: 549 ILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTV-TVRVCACDHHGNMQSCHAEALIH 607
+ +R + + L V +D P+++ + V + D + N+
Sbjct: 1477 TIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNV---------- 1526
Query: 608 PTGLSTGALVAILLCIVILLVTVVLFA 634
P +S AL A ++ ++T ++ A
Sbjct: 1527 PMFISQNALAADPSAVIGSVLTTIMAA 1553
Score = 179 bits (453), Expect = 1e-44
Identities = 152/529 (28%), Positives = 250/529 (47%), Gaps = 47/529 (8%)
Query: 73 YVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAIN 132
+VG + + + ++ Y+++ +F IN+ TG + +DREE+ Y L+ A
Sbjct: 811 HVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-- 868
Query: 133 RRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYG 192
+G V ++ I + D+NDN P F + + + V E G + Q A D D+ G
Sbjct: 869 --SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDE---G 923
Query: 193 NSAKVVYSILQG-QPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGT 251
+ V+YS+ Q + F++ + G I +LL + YQ+ I A DMG + LS +
Sbjct: 924 VNGMVLYSLKQNPKNLFAINEKNGTI--SLLGPLDVHAGSYQIEILASDMG--VPQLSSS 979
Query: 252 TTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGE 311
+ + + DVNDN P F Q +Y+ ES P + +++ASD D G N EI Y+I +G
Sbjct: 980 VILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGN 1039
Query: 312 GLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVR 371
D F + D G + +K LD E + Y L V AS+ VE P + V
Sbjct: 1040 TGDAFGIFPD-----GQLYIKSELDRELQDRYVLMVVASDRAVE-------PLSATVNVT 1087
Query: 372 IVVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDR 429
+++EDV D P+F+ Y E+ + + +G V+A D D N V+YS + +
Sbjct: 1088 VILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM---VQP 1144
Query: 430 IFNIDSGNGSIFTSKLLDRETLLWH------NITVIATEINNP---KQSSRVPLYIKVLD 480
F + + +G I + DRE+L+ + TVIAT+ P K + V +Y+K D
Sbjct: 1145 DFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMK--D 1202
Query: 481 VNDNAPEF-AEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTI 539
+NDNAP+F +FY+ + E A + + A D D+ +G L + N
Sbjct: 1203 INDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNG------LIHYSIIKGNEER 1256
Query: 540 QDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
Q D+T+G +T + Y L + D+ +ST T+ + +
Sbjct: 1257 QFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDI 1305
Score = 171 bits (434), Expect = 2e-42
Identities = 162/515 (31%), Positives = 245/515 (47%), Gaps = 41/515 (7%)
Query: 79 SDQDRGD-GSLKYILS-GDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTG 136
+D D GD G++++ L + F ++ +G + LDREE+ Y L A + G
Sbjct: 608 TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATD--LG 665
Query: 137 RPVEPESEFI-IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSA 195
P + I + + DINDN P+F Y A + E G+++ V+ATD P G +
Sbjct: 666 SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATD---PDLGTNG 722
Query: 196 KVVYSILQG-QPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTV 254
V YSI G + F V +++G+I T + +DRE + YQ+ I A D G V
Sbjct: 723 TVKYSISAGDRSRFQVNAQSGVISTRMA-LDREEKTAYQLQIVATDGGNLQS--PNQAIV 779
Query: 255 NITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLD 314
IT+ D DNPP F Q Y F E+ G +G + AS D+ N+ I Y IT G+
Sbjct: 780 TITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKG 837
Query: 315 MFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV 374
MF + +Q T G +T ++D E++ Y LKV AS G V I V
Sbjct: 838 MFAI--NQVT--GQLTTANVIDREEQSFYQLKVVASG----------GTVTGDTMVNITV 883
Query: 375 EDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDRIFN 432
+D+ D P F + + + E+ Q +I A DPD N V YS+ ++ +F
Sbjct: 884 KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNP--KNLFA 941
Query: 433 IDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF- 491
I+ NG+I LD + I ++A+++ P+ SS V L + V DVNDN+P F +
Sbjct: 942 INEKNGTISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLS 1000
Query: 492 YETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILT 551
YE + E + + A DKD +G + ++++A E +G F I + G L
Sbjct: 1001 YEVTLSESEPVNSRFFKVQASDKDSGANG-EIAYTIA-EGNTGDAFGIFPD-----GQLY 1053
Query: 552 RKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTV 586
K+ +R Y+L VV SD S+T VTV
Sbjct: 1054 IKSELDRELQDRYVLMVVASDRAVEPLSATVNVTV 1088
Score = 160 bits (404), Expect = 6e-39
Identities = 164/530 (30%), Positives = 247/530 (46%), Gaps = 48/530 (9%)
Query: 79 SDQDRGDGS-LKY-ILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTG 136
+D D G S L Y I SGD G F +++N G ++ K LDRE + Y L Q +
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQ-FTVDKN-GVLKVLKALDRESQSFYNLVVQVHDL--- 2023
Query: 137 RPVEPESEFI------IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPT 190
P P S F I + D+NDN P F T +PE + + T V + ATD D
Sbjct: 2024 -PQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDPDS-- 2079
Query: 191 YGNSAKVVYSILQGQPY-FSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLS 249
G ++ + Y++L FS+ + G ++ +DRE Y + + A D G LS
Sbjct: 2080 -GPNSYIEYTLLNPLGNKFSIGTIDGEVRLTG-ELDREEVSNYTLTVVATDKG--QPSLS 2135
Query: 250 GTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITD 309
+T V + + D+NDN P F Q+ Y+ + E++ GT I ++ A+D D G N ++ Y I +
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195
Query: 310 GEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSAT 369
G F + ++ G ITV K LD EK Y L V+A++ PR D++T
Sbjct: 2196 GNTNQEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPR-------TDTST 2244
Query: 370 VRIVVEDV-DEPPVFSKLAYILQIRED-AQINTTIGSVTAQDPDAARNPVKYSVDRHTDM 427
V IV+ D+ D PVF Y + + E+ + TI V A+D D N V +
Sbjct: 2245 VSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE 2304
Query: 428 DRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPE 487
D F + S +G + ++ LDRET + + AT+ +P + + + V DVNDN P
Sbjct: 2305 DNAFTL-SASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT 2363
Query: 488 FA-EFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNT 546
FA + Y T + E A + ++A D D + ++ S FTI +T
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNASDADASKN------AVIRIIGGNSQFTI---NPST 2414
Query: 547 AGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGN 596
I+T +R Y L VV SD P S+ T +V V D + N
Sbjct: 2415 GQIITSAL-LDRETKDNYTLVVVCSDAGSPEPLSSST-SVLVTVTDVNDN 2462
Score = 157 bits (397), Expect = 4e-38
Identities = 138/516 (26%), Positives = 248/516 (48%), Gaps = 32/516 (6%)
Query: 80 DQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138
D+D G +G L Y + + F IN TG+I++ + LDRE+ Y+L ++ ++ G P
Sbjct: 2694 DKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK--GSP 2751
Query: 139 VEPES-EFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKV 197
+ S + +I I D NDN P F+ ++++A VPE S +G V +VT +D D G +A
Sbjct: 2752 SQSTSVKVMINILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDED---IGINAIS 2807
Query: 198 VYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 257
YSI+ F++ TG I + ++RE+ ++Y++ + A D G + +T V I
Sbjct: 2808 RYSIMDASLPFTINPSTGDIVISR-PLNREDTDRYRIRVSAHDSGWTV-----STDVTIF 2861
Query: 258 LTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFD 317
+TD+NDN PRF +++Y PE + G+ + ++ A+D D G N ++ Y I +
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRIN 2921
Query: 318 VITDQETQEGIITVKKLLDFEKKKVYTLK-VEASNPYVEPRFLYLGPFKDSATVRI-VVE 375
T + + I+ + + F + + S+ +P + TV I +V+
Sbjct: 2922 ATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLI------SETTVTINIVD 2975
Query: 376 DVDEPPVFSKLAYILQIREDAQINTTIGSVTA-QDPDAARN-PVKYSVDRHTDMDRIFNI 433
D P F K Y + ++ ++ T + VTA D D N V+Y + + + F +
Sbjct: 2976 SNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK-FKL 3034
Query: 434 DSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFY- 492
D+ G I + L + ITV A + NP SS+ ++I V + N + PEF++ +
Sbjct: 3035 DNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHM 3094
Query: 493 ETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTR 552
+ E +++T+ A D+D +G +S++ G F I +++ GILT
Sbjct: 3095 SATIPESHSIGSIVRTVSARDRDAAMNG-LIKYSISSGNEEGI-FAI----NSSTGILTL 3148
Query: 553 KNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+ + + + D + ++ +VTV V
Sbjct: 3149 AKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNV 3184
Score = 150 bits (379), Expect = 4e-36
Identities = 158/556 (28%), Positives = 248/556 (44%), Gaps = 44/556 (7%)
Query: 79 SDQDRGDGS-LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGR 137
+D D GD + L Y ++G F I+ NTG I K+LD E + +Y L A ++ GR
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ--GR 1397
Query: 138 PVEPES-EFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAK 196
P + +I + D NDN P F ++ E +GT V+ VTA D D G +
Sbjct: 1398 PPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADING---Q 1454
Query: 197 VVYSILQGQP---YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLS-GTT 252
+ Y+I+Q P +F+++ G I T +DRE +++ ++A D +
Sbjct: 1455 LSYTIIQQMPRGNHFTIDEVKGTIYTNA-EIDREFANLFELTVKANDQAVPIETRRYALK 1513
Query: 253 TVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEG 312
V I +TD+NDN P F P S+ G+ + I A+D D G N EIEY I +G+
Sbjct: 1514 NVTILVTDLNDNVPMFISQNALAADP-SAVIGSVLTTIMAADPDEGANGEIEYEIINGD- 1571
Query: 313 LDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRI 372
D F V + G + V L + +Y L V A++ E R K + + I
Sbjct: 1572 TDTFIV----DRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERR-------KSTTELTI 1619
Query: 373 VVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSV----DRHTDMD 428
+++ +D P VF++ YI ++E I T + S+ A P + PV+Y + +
Sbjct: 1620 ILQGLDGP-VFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVG 1678
Query: 429 RIFNIDSGNGSIFTSKLLDRET-LLWHNITVIATEINNP-KQSSRVPLYIKVLDVNDNAP 486
R+F I G I T+ +LDRE + + V A E + ++ R + I + D+NDN P
Sbjct: 1679 RLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPP 1738
Query: 487 EF-AEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDN 545
F + + V E I L A+D D+ G + + + +F I D
Sbjct: 1739 VFPTDMLDLTVEENIGDGSKIMQLTAMDADE---GANALVTYTIISGADDSFRI----DP 1791
Query: 546 TAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEAL 605
+G L +R S Y L V D +QSS + + V + H S +
Sbjct: 1792 ESGDLIATRRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 606 IHPTGLSTGALVAILL 621
P G+LVA +L
Sbjct: 1849 DIPEDTIPGSLVAAIL 1864
Score = 147 bits (372), Expect = 3e-35
Identities = 130/444 (29%), Positives = 203/444 (45%), Gaps = 48/444 (10%)
Query: 100 LFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIF 159
LF IN +TG + T +DRE P ++ ++ P E + + D+NDN P+F
Sbjct: 80 LFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR----VLVRDLNDNAPVF 135
Query: 160 TKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKT 219
T E S G V+ TATD+D + G + Y I++G + + +
Sbjct: 136 PDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRS-YRIIRGNEAGRFRLDITLNPS 194
Query: 220 ---ALLNM------DRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQ 270
A L++ DRE QYQ++++ +D G G VN+T+ D+NDNPP F
Sbjct: 195 GEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKR--RGYLQVNVTVQDINDNPPVFGS 252
Query: 271 STYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIIT 330
S YQ PE + G+ + ++ A+DAD G NA+I Y + D EG + + G+IT
Sbjct: 253 SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD-EGTPF-----QMDPETGLIT 306
Query: 331 VKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPV-----FS 384
V++ LDFE ++ Y+L V+A + V A I + DV D PV F
Sbjct: 307 VREPLDFEARRQYSLTVQAMDRGVP-------SLTGRAEALIQLLDVNDNDPVVKFRYFP 359
Query: 385 KLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVD-RHTDMDRIFNIDSGN----GS 439
+ + E+AQ+ T + +T D D+ SV + R F + S
Sbjct: 360 ATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL 419
Query: 440 IFTSKLLDRETLLWHNITV-IATEINNP------KQSSRVPLYIKVLDVNDNAPEFA-EF 491
I + LDRE + +N+TV ++ P +SS L I V D+ND+ P F+ +
Sbjct: 420 IKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQV 479
Query: 492 YETFVCEKAKADQLIQTLHAVDKD 515
Y + E+A + + A D D
Sbjct: 480 YRVNLSEEAPPGSYVSGISATDGD 503
Score = 140 bits (354), Expect = 4e-33
Identities = 123/387 (31%), Positives = 175/387 (45%), Gaps = 40/387 (10%)
Query: 67 TGSDYQYVGKLHSDQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYI 125
TG+D V +D D G +G ++Y + F I+ TG I K LDRE+ P Y
Sbjct: 2169 TGTDIIQV--FAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYH 2226
Query: 126 LRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATD 185
L QA +R + P S I + DIND P+F Y+ VPE ++GT +
Sbjct: 2227 LTVQATDRGS-TPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPE--NLGTLPRTILQVV 2283
Query: 186 ADDPTYGNSAKVVYSILQGQP----YFSVESETGIIKTALLNMDRENREQYQVVIQAKDM 241
A D G+++K+ Y + G S E G+ ++ +DRE +E++ ++I A D
Sbjct: 2284 ARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQS----LDRETKERFVLMITATDS 2339
Query: 242 GGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENA 301
G L+GT T+N+ + DVNDN P F Y PE +P GT + + ASDAD +NA
Sbjct: 2340 GSP--ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNA 2397
Query: 302 EIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKV---EASNPYVEPRF 358
I I G + T Q I LLD E K YTL V +A +P
Sbjct: 2398 VIR--IIGGNSQFTINPSTGQ------IITSALLDRETKDNYTLVVVCSDAGSP------ 2443
Query: 359 LYLGPFKDSATVRIVVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-P 416
P S +V + V DV D PP F Y+ I + + +VT D D N
Sbjct: 2444 ---EPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSE 2500
Query: 417 VKYSVDRHTDMDRIFNIDSGNGSIFTS 443
+ YS+ F+ID G+I +
Sbjct: 2501 LHYSLSGRN--SEKFHIDPLRGAIMAA 2525
Score = 138 bits (347), Expect = 2e-32
Identities = 125/453 (27%), Positives = 210/453 (46%), Gaps = 35/453 (7%)
Query: 67 TGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYIL 126
TG+D V SD D ++ I+ G+ F IN +TG I + LDRE K Y L
Sbjct: 2379 TGTDVLLVNA--SDADASKNAVIRIIGGNSQ---FTINPSTGQIITSALLDRETKDNYTL 2433
Query: 127 RAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDA 186
+ + P+ + ++ + D+NDN P F Y +P + G+FV VT TDA
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDA 2493
Query: 187 DDPTYGNSAKVVYSIL-QGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQM 245
D G ++++ YS+ + F ++ G I A + + KD GG
Sbjct: 2494 D---IGPNSELHYSLSGRNSEKFHIDPLRGAIMAA---GPLNGASEVTFSVHVKD-GGSF 2546
Query: 246 GGLSGTTTVNITLTDVNDNPP-RFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIE 304
+ +TTV + + D P R + T+ F PE+ P + + I S +
Sbjct: 2547 -PKTDSTTVTVRFVNKADFPKVRAKEQTFMF--PENQPVSSLVTTITGSSL---RGEPMS 2600
Query: 305 YSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPF 364
Y I G + F + DQ T G +++ + LDFEK + Y + ++E R PF
Sbjct: 2601 YYIASGNLGNTFQI--DQLT--GQVSISQPLDFEKIQKYVV-------WIEARDGGFPPF 2649
Query: 365 KDSATVRIVVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVD 422
+ I V DV D P+F + +I +I E+ + +V+A D D+ N + Y +
Sbjct: 2650 SSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEI- 2707
Query: 423 RHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVN 482
+ +M+ F+I+ G I + + LDRE + + +T+ +++ +P QS+ V + I +LD N
Sbjct: 2708 VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEN 2767
Query: 483 DNAPEFAEFYETFVCEKAKADQLIQTLHAVDKD 515
DNAP F++ + V E + + + D+D
Sbjct: 2768 DNAPRFSQIFSAHVPENSPLGYTVTRVTTSDED 2800
Score = 122 bits (307), Expect = 1e-27
Identities = 117/425 (27%), Positives = 191/425 (44%), Gaps = 29/425 (6%)
Query: 79 SDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138
+D D G ++ DLF+I+ NTG I LD E K Y L +A N P
Sbjct: 3219 TDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNV----P 3274
Query: 139 VEPESEFI---IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSA 195
E F I++ N+ P F ++Y + E + GT V +V A+D D T G
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVH 3334
Query: 196 KVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVN 255
+++ + + F + +TG I + + +DRE E+ + + AK+ G G TVN
Sbjct: 3335 YLIFGNSRKKG-FQINKKTGQIYVSGI-LDREKEERVSLKVLAKNFGSIRGADIDEVTVN 3392
Query: 256 ITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDAD-VGENAEIEYSITDGEGLD 314
+T+ D ND PP F + Y + E P GT + + A D+D + + Y I G
Sbjct: 3393 VTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENG 3451
Query: 315 MFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV 374
F + Q G ITV LD E +Y L V A + SA++ + +
Sbjct: 3452 AFSI----NPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA-------TGSASLLVTL 3500
Query: 375 EDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN--PVKYSVDRHTDMDRIF 431
ED+ D P+ + ++ E+ + T + ++ + DPD N P Y + F
Sbjct: 3501 EDINDNGPMLTVSEG--EVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYF 3558
Query: 432 NIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF 491
++ + G + T++ +DRE + ++V+ + P+ SS ++I V+D NDN P +
Sbjct: 3559 SLSTA-GVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-PSQSRT 3616
Query: 492 YETFV 496
E FV
Sbjct: 3617 VEIFV 3621
Score = 91.3 bits (225), Expect = 3e-18
Identities = 76/247 (30%), Positives = 110/247 (44%), Gaps = 16/247 (6%)
Query: 68 GSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILR 127
G+ +V SD Y + F IN TG I T LDRE P+Y L
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 128 AQAINRRTGRP-VEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDA 186
A++ +G P + ++ + DINDN P+ T V V E GT V+ + +TD
Sbjct: 3480 VLAVD--SGTPSATGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDP 3535
Query: 187 DDPTYGNSAKVVYSILQGQP---YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGG 243
D P N Y +L P YFS+ S G++ T +DRE + + + KD G
Sbjct: 3536 DLPP--NQGPFTYYLLSTGPATSYFSL-STAGVLSTT-REIDREQIADFYLSVVTKDSG- 3590
Query: 244 QMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEI 303
+ +S T TV+IT+ D NDNP + + PG +G +K D DV ++
Sbjct: 3591 -VPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDS--F 3647
Query: 304 EYSITDG 310
S+T G
Sbjct: 3648 HCSLTSG 3654
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 207 bits (527), Expect = 3e-53
Identities = 168/514 (32%), Positives = 246/514 (47%), Gaps = 32/514 (6%)
Query: 80 DQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138
D D G +G ++Y L G G + F+ E+ G+++ LDRE PVY L A+A + GR
Sbjct: 3055 DADIGSNGYIRYSLYGSGNSEFFLDPES-GELKTLALLDRERIPVYSLMAKATDGG-GRF 3112
Query: 139 VEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVV 198
+ I++ D+NDN P+F+ + Y V E + + +V A D P G + KVV
Sbjct: 3113 CQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVD---PDIGINRKVV 3167
Query: 199 YSILQGQP-YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMG-GQMGGLSGTTTVNI 256
YS+ FS++S +GII +DRE + Y + ++A D GQ LS TTV I
Sbjct: 3168 YSLADSAGGVFSIDSSSGIIILEQ-PLDREQQSSYNISVRATDQSPGQ--SLSSLTTVTI 3224
Query: 257 TLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMF 316
T+ D+NDNPP F + Y PE + PGT + + A+ D+G NAEI Y I G F
Sbjct: 3225 TVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKF 3284
Query: 317 DVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVED 376
+ + G I+V ++LD+E K + L VEA + ATV I + D
Sbjct: 3285 KI----NPKTGGISVSEVLDYELCKRFYLVVEAKDGGTP-------ALSAVATVNINLTD 3333
Query: 377 V-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDS 435
V D PP FS+ Y I EDA + ++ + A+D D+ N + + D D F +D
Sbjct: 3334 VNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP 3393
Query: 436 GNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF-YET 494
G + K LDRE + +++ V A + P SS + I + DVNDN+P F Y
Sbjct: 3394 VLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTA 3453
Query: 495 FVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKN 554
+ E I L D+D ++G FSFS+ F + + GIL
Sbjct: 3454 VIQENKPVGTSILQLVVTDRDSFHNGPPFSFSIL-SGNEEEEFVLDPH-----GILRSAV 3507
Query: 555 GYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+ E Y+L V D+ P Q S + VRV
Sbjct: 3508 VFQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRV 3541
Score = 207 bits (526), Expect = 4e-53
Identities = 156/516 (30%), Positives = 258/516 (50%), Gaps = 30/516 (5%)
Query: 80 DQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRP 138
D D G +G + + +S F I+ TG ++ +DRE +Y+L + G P
Sbjct: 752 DADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYD--LGNP 809
Query: 139 VEPESEFI-IKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKV 197
+ + I + D NDN P+F ++ Y+ + E S +GT ++QV A D D G++ +V
Sbjct: 810 QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD---LGSNGEV 866
Query: 198 VYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 257
YS+L F++ S TGI+ A +DRE++ Y + I+A+D L T+ +
Sbjct: 867 TYSVLTDTQQFAINSSTGIVYVAD-QLDRESKANYSLKIEARDKAESGQQLFSVVTLKVF 925
Query: 258 LTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFD 317
L DVND P F S+Y K E P GT I ++ D D+G ++ YS+ + F+
Sbjct: 926 LDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYN-GRFE 984
Query: 318 VITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV 377
+ + G I + K LD+EK++ Y L V A + + R + L + V + V DV
Sbjct: 985 I----DKASGAIRLSKELDYEKQQFYNLTVRAKD---KGRPVSL---SSVSFVEVEVVDV 1034
Query: 378 DE---PPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHTDMDRIFNI 433
+E P F A + ++E+++I T++ VTA+D D+ R+ ++YS+ + + R F+I
Sbjct: 1035 NENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR-FSI 1093
Query: 434 DSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE-FY 492
D +G I + +LDRET+ + +TV AT+ S + +YI+V DVNDNAP +E Y
Sbjct: 1094 DDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 493 ETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTR 552
V E + D + + A +DP S + + + NF + K T I T
Sbjct: 1154 YPVVMENSPKDVSVIQIQA---EDPDSSSNEKLTYRITSGNPQNFFAINIK--TGLITTT 1208
Query: 553 KNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+R + + + L V ++D + ST V V+V
Sbjct: 1209 SRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQV 1244
Score = 183 bits (464), Expect = 6e-46
Identities = 151/519 (29%), Positives = 250/519 (48%), Gaps = 35/519 (6%)
Query: 77 LHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTG 136
+++ G G + I+ GD F I+ +TG ++ LD E Y L +A + TG
Sbjct: 2208 INATSPEGQGIIYIIIDGDPFKQ-FNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTG 2266
Query: 137 RPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAK 196
E + ++ +D+NDN PIF + Y T+ E S +GT V+QV + DAD N+
Sbjct: 2267 ARAEVTVDLLV--NDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSE---NNKM 2321
Query: 197 VVYSILQ----GQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTT 252
V Y I+Q YF ++S +G+I TA + +D E + + +++ D G LS
Sbjct: 2322 VHYQIVQDTYNSTDYFHIDSSSGLILTARM-LDHELVQHCTLKVRSIDSG--FPSLSSEV 2378
Query: 253 TVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEG 312
V+I ++DVNDNPP F Q Y+ E +P G + ++ASDAD + +EYSI G
Sbjct: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGND 2438
Query: 313 LDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRI 372
F + +++ G+IT+ + +Y+L V S+ G F +A V I
Sbjct: 2439 RTSFLM----DSKSGVITLSNHRKQRMEPLYSLNVSVSD----------GLFTSTAQVHI 2484
Query: 373 VVEDVD-EPPVFSKLAYILQIREDAQINTTIGSVTAQDPD-AARNPVKYSVDRHTDMDRI 430
V + P FS+ Y+ ++RE+ T + V A D D + Y++ DR
Sbjct: 2485 RVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR- 2543
Query: 431 FNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE 490
F IDS NG + T++ LDRE L ++++ ++ +++ + + V+D NDNAP+F
Sbjct: 2544 FLIDS-NGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMT 2602
Query: 491 F-YETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGI 549
Y V L+ + A+D DD + + ++SL EA+ ++ + DN G
Sbjct: 2603 VEYRASVRADVGRGHLVTQVQAIDPDDG-ANSRITYSLYSEASVSVADLLEIDPDN--GW 2659
Query: 550 LTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+ K +N+ + + V D PV+ S V + V
Sbjct: 2660 MVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHV 2698
Score = 166 bits (419), Expect = 1e-40
Identities = 147/517 (28%), Positives = 245/517 (47%), Gaps = 36/517 (6%)
Query: 80 DQDRG-DGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINR-RTGR 137
D+D G +G + Y + D F IN +TG + +LDRE K Y L+ +A ++ +G+
Sbjct: 857 DKDLGSNGEVTYSVLTDT--QQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQ 914
Query: 138 PVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKV 197
+ + + D+ND P F Y+ V E VGT + + + DP G +V
Sbjct: 915 QLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWL---ETHDPDLGLGGQV 971
Query: 198 VYSILQG-QPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNI 256
YS++ F ++ +G I+ + +D E ++ Y + ++AKD G + LS + V +
Sbjct: 972 RYSLVNDYNGRFEIDKASGAIRLSK-ELDYEKQQFYNLTVRAKDKGRPVS-LSSVSFVEV 1029
Query: 257 TLTDVNDN--PPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLD 314
+ DVN+N P FP E+S GT + ++ A D D G + EI+YSI DG GL
Sbjct: 1030 EVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLG 1089
Query: 315 MFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV 374
F + + + G+IT +LD E Y L V A++ V P + + V I V
Sbjct: 1090 RFSI----DDESGVITAADILDRETMGSYWLTVYATDRGVVPLY-------STIEVYIEV 1138
Query: 375 EDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNI 433
EDV D P+ S+ Y + E++ + ++ + A+DPD++ N + F I
Sbjct: 1139 EDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAI 1198
Query: 434 DSGNGSIFT-SKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAE-F 491
+ G I T S+ LDRE H + V T+ + S + + ++VLD NDN P+F E
Sbjct: 1199 NIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKV 1258
Query: 492 YETFVCE--KAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGI 549
Y+ + E + K + I A D+D+ + + S+S+ G F D G+
Sbjct: 1259 YQIKLPERDRKKRGEPIYRAFAFDRDEGPNA-EISYSIVDGNDDGKFFI-----DPKTGM 1312
Query: 550 LTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTV 586
++ + + S +L + DN P +SST + +
Sbjct: 1313 VSSRKQFTAG--SYDILTIKAVDNGRPQKSSTARLHI 1347
Score = 153 bits (386), Expect = 7e-37
Identities = 145/453 (32%), Positives = 205/453 (45%), Gaps = 45/453 (9%)
Query: 80 DQDRG-DGSLKYILSGDGAGD----LFIINENTGDIQATKRLDREEKPVYILRAQAINRR 134
D D G +G + Y L D + F I+ NTG I K LD E P + A +
Sbjct: 2840 DMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLG 2899
Query: 135 TGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNS 194
+ + +++ DINDN P+F +EVY V E G V ++ D D T +
Sbjct: 2900 EAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRD--TSDVN 2957
Query: 195 AKVVYSILQGQPYFS-----VESETGI-IKTALLNMDRENREQYQVVIQAKDMGGQMGGL 248
+V Y I G P V+SE + +K L DRE ++ Y + I A D GL
Sbjct: 2958 RQVSYHITGGNPRGRFALGLVQSEWKVYVKRPL---DREEQDIYFLNITATD------GL 3008
Query: 249 SGTTT-VNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSI 307
T V ++++DVNDN P Q Y PE P I ++ A DAD+G N I YS+
Sbjct: 3009 FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL 3068
Query: 308 TDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDS 367
+ F + + G + LLD E+ VY+L +A++ G F S
Sbjct: 3069 YGSGNSEFF-----LDPESGELKTLALLDRERIPVYSLMAKATDGG--------GRFCQS 3115
Query: 368 ATVRIVVEDV-DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARN-PVKYSVDRHT 425
+ +++EDV D PPVFS Y + E+ + V A DPD N V YS+
Sbjct: 3116 -NIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSL--AD 3172
Query: 426 DMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQ--SSRVPLYIKVLDVND 483
+F+IDS +G I + LDRE +NI+V AT+ +P Q SS + I VLD+ND
Sbjct: 3173 SAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD-QSPGQSLSSLTTVTITVLDIND 3231
Query: 484 NAPEF-AEFYETFVCEKAKADQLIQTLHAVDKD 515
N P F Y V E + + A KD
Sbjct: 3232 NPPVFERRDYLVTVPEDTSPGTQVLAVFATSKD 3264
Score = 135 bits (341), Expect = 1e-31
Identities = 127/446 (28%), Positives = 208/446 (46%), Gaps = 40/446 (8%)
Query: 87 SLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFI 146
+L Y + +F IN +G I K LD E Y L QA N + +
Sbjct: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG---MASNATVN 1756
Query: 147 IKIHDINDNEPIFTKEVYTATVPEMSDVGTFV-------VQVTATDADDPTYGNSAKVVY 199
I+I D NDN P+F Y+ ++ E + + + V + + ATDAD +A +VY
Sbjct: 1757 IQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADS---NRNALLVY 1813
Query: 200 SILQG--QPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNIT 257
I++ + +F+V+S TG I+T + N+D E + + +D G VNI
Sbjct: 1814 QIVESTAKKFFTVDSSTGAIRT-IANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIE 1872
Query: 258 LTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFD 317
+TDVNDNPP F Q+ ++ + G + ++ A+D D E+ YS+ +G LD F
Sbjct: 1873 VTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG-SLDHFL 1931
Query: 318 VITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV-ED 376
+ ++ G++T+K + K Y L V+ S+ G F ++ V I+V E
Sbjct: 1932 I----DSNSGVLTIKN--NNLSKDHYMLIVKVSD----------GKFYSTSMVTIMVKEA 1975
Query: 377 VDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSG 436
+D F++ Y I E+ T + V A + P+KYS+ + F I S
Sbjct: 1976 MDSGLHFTQSFYSTSISENNTNITKVAIVNAVG-NRLNEPLKYSI---LNPGNKFKIKST 2031
Query: 437 NGSIFTSKL-LDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF-YET 494
+G I T+ + DRE + + V A+ + + +RV + + + D+NDN+P F Y
Sbjct: 2032 SGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYA 2091
Query: 495 FVCEKAKADQLIQTLHAVDKDDPYSG 520
V A+ LI + A+DKD +G
Sbjct: 2092 AVQVDAEPGTLIYQVTAIDKDKGPNG 2117
Score = 124 bits (310), Expect = 4e-28
Identities = 130/520 (25%), Positives = 230/520 (44%), Gaps = 44/520 (8%)
Query: 88 LKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFII 147
L + + G F + G I K LD E++ +Y + + + G V FI
Sbjct: 1393 LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD---GTNVAVTQVFI- 1448
Query: 148 KIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQG--Q 205
K+ D NDN P F++ Y T+ E T ++Q+ ATD D+ + V+S +
Sbjct: 1449 KVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKH--KLSYTVHSSIDSISM 1506
Query: 206 PYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNP 265
F ++ TG++ TA +D E ++++ + I +D + V + + D ND+
Sbjct: 1507 RKFRIDPSTGVLYTAE-RLDHEAQDKHILNIMVRDQ--EFPYRRNLARVIVNVEDANDHS 1563
Query: 266 PRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQ 325
P F Y+ ES+ G+ + ++ A D D GENAE+ Y+I G +MF + E
Sbjct: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKI----EPV 1619
Query: 326 EGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEP-PVFS 384
GIIT+ K D + L ++ ++ P +A VRI V D P F
Sbjct: 1620 LGIITICKEPDMTTMGQFVLSIKVTDQGSP-------PMSATAIVRISVTMSDNSHPKFI 1672
Query: 385 KLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSK 444
Y ++ E+ I T++ ++A +++ + Y V + D++ IF I+ +G I T K
Sbjct: 1673 HKDYQAEVNENVDIGTSVILISA----ISQSTLIYEV-KDGDINGIFTINPYSGVITTQK 1727
Query: 445 LLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFA-EFYETFVCEKAKAD 503
LD E + + + AT N +S + I+++D NDNAP F Y + E A +
Sbjct: 1728 ALDYERTSSYQLIIQAT--NMAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
Query: 504 QLIQTL-------HAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGY 556
++++L A D D + + E+ + FT+ D++ G +
Sbjct: 1786 SIVRSLDNSPLVIRATDADS--NRNALLVYQIVESTAKKFFTV----DSSTGAIRTIANL 1839
Query: 557 NRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGN 596
+ ++ + V + D+ P ++ V V + D + N
Sbjct: 1840 DHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDN 1879
Score = 107 bits (266), Expect = 6e-23
Identities = 114/427 (26%), Positives = 194/427 (45%), Gaps = 45/427 (10%)
Query: 116 LDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVG 175
L+RE + Y+L + R G +E ++ I++ D+ND P+F+ Y+ T+ E + +
Sbjct: 117 LNREIQDNYLLIVKGSVR--GEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLR 174
Query: 176 TFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIK-TALLNMDRENREQYQV 234
T V QVTATDAD G++ + Y FSV +G+I + LN D +NR Y +
Sbjct: 175 TSVAQVTATDAD---IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNR--YDL 229
Query: 235 VIQAKDMGGQM---GGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIK 291
I A D G ++ G+S T + + + +N++ P T+ P S +
Sbjct: 230 EILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTH---VPFSLEKEPTYAVVT 286
Query: 292 ASDADVGENAEIE-YSITDGEGLDMFDVITDQE-TQEGIITVKKLLDFEKKKV-YTLKVE 348
D D G N EIE SI G+ LD F + + + E I +K +D+E Y L ++
Sbjct: 287 VDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 349 ASNPYVEP-----RFLYLG-PFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTI 402
A + + +Y+G P +D+ +R F K Y + I E + +
Sbjct: 347 AKDKGSPQKCSALKAVYIGNPTRDTVPIR-----------FEKEVYDVSISEFSPPGVVV 395
Query: 403 GSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATE 462
++ P+ V+Y + D F I+ +G I T++ L+ V E
Sbjct: 396 -AIVKLSPEPI--DVEYKLSPGEDA-VYFKINPRSGLIVTARPLNTV-----KKEVYKLE 446
Query: 463 INNPKQSSRVPLYIKVLDVNDNAPEFAE-FYETFVCEKAKADQLIQTLHAVDKDDPYSGH 521
+ N + + + I + D ND+ PEF + Y+ +V E + T+ A DKD +G+
Sbjct: 447 VTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 522 QFSFSLA 528
++S+A
Sbjct: 507 -ITYSIA 512
Score = 107 bits (266), Expect = 6e-23
Identities = 146/579 (25%), Positives = 238/579 (41%), Gaps = 89/579 (15%)
Query: 91 ILSGDGAGDLFIINE----NTGDIQATKRLDREEKPV-YILRAQAINRRTGRPVEPESEF 145
I++GD F+ E N I+ K++D E P Y L QA ++ G P + +
Sbjct: 303 IVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK--GSPQKCSALK 360
Query: 146 IIKI-HDINDNEPI-FTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQ 203
+ I + D PI F KEVY ++ E S G V V + V Y +
Sbjct: 361 AVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSP-------EPIDVEYKLSP 413
Query: 204 GQP--YFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDV 261
G+ YF + +G+I TA ++ +E Y++ + K+ G L T++I D
Sbjct: 414 GEDAVYFKINPRSGLIVTAR-PLNTVKKEVYKLEVTNKE-----GDLKAQVTISIE--DA 465
Query: 262 NDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITD 321
ND+ P F Q Y ES P GT + + ASD D GEN I YSI L++ + +
Sbjct: 466 NDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIA---SLNLLPFVIN 522
Query: 322 QETQEGIITVKKLLDFEKK-KVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV---EDV 377
Q T G+I+ + LDFE ++Y V AS+ + P++ + V + +
Sbjct: 523 QFT--GVISTTEELDFESSPEIYRFIVRASD--------WGSPYRHESEVNVTIRIGNVN 572
Query: 378 DEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGN 437
D P+F K+A I D + I +V+A D D VKY + ++ F ++ +
Sbjct: 573 DNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDEL-ELVKYKIISGNELG-FFYLNPDS 630
Query: 438 GSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVC 497
G + K L + N + T + + + + I VL ++ F+ ET V
Sbjct: 631 GVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFS-CRETRVA 689
Query: 498 EKAKADQLIQT--------------LHAVDKDDPYSGHQFSFSLAP-------------- 529
+K LI+ +++++ PY F +A
Sbjct: 690 QKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK 749
Query: 530 --EAASGSN----FTIQD-------NKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYP 576
+A SG N FTI D N D G L +R YLL + I D P
Sbjct: 750 AYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNP 809
Query: 577 VQSSTGTVTVRVCACDHHGN--MQSCHAEALIHPTGLST 613
+SS +T+ V + + +Q ++ ++ +G+ T
Sbjct: 810 QKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGT 848
Score = 106 bits (264), Expect = 1e-22
Identities = 126/538 (23%), Positives = 234/538 (43%), Gaps = 45/538 (8%)
Query: 56 MWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKR 115
++ LL Y G + V D + L Y L +G+ D F+I+ N+G + T +
Sbjct: 1887 VFETILLLPTYVGVEVLKVSATDPDSEVPP-ELTYSLM-EGSLDHFLIDSNSGVL--TIK 1942
Query: 116 LDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVG 175
+ K Y+L + + + S I + + D+ FT+ Y+ ++ E +
Sbjct: 1943 NNNLSKDHYMLIVKVSDGK----FYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNI 1998
Query: 176 TFVVQVTATDADDPTYGN--SAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQ 233
T V V A GN + + YSIL F ++S +G+I+T + DRE +E Y+
Sbjct: 1999 TKVAIVNAV-------GNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYE 2051
Query: 234 VVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKAS 293
+V++A + V + + D+NDN P F Y + PGT I ++ A
Sbjct: 2052 LVVEASRELDHLR--VARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAI 2109
Query: 294 DADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKV-YTLKVEASNP 352
D D G N E+ Y + D G F++ G + +K+ + + + Y + + A +
Sbjct: 2110 DKDKGPNGEVTYVLQDDYG--HFEI----NPNSGNVILKEAFNSDLSNIEYGVTILAKDG 2163
Query: 353 YVEPRFLYLGPFKDSATVRIVVEDVDEP-PVFSKLAYILQIREDAQINTTIGSVTAQDPD 411
G S +V + + V++ PVF K Y + ED ++NT I S+ A P+
Sbjct: 2164 ---------GKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE 2214
Query: 412 AARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSR 471
+ + +D D + FNID G + LD E + +T+ A++ + +
Sbjct: 2215 -GQGIIYIIID--GDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGAR-AE 2270
Query: 472 VPLYIKVLDVNDNAPEFAE-FYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPE 530
V + + V DVNDN P F + Y T + E + + + ++D D + + + +
Sbjct: 2271 VTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSE-NNKMVHYQIVQD 2329
Query: 531 AASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRV 588
+ +++ + D+++G++ + + L V D+ +P SS V + +
Sbjct: 2330 TYNSTDYF---HIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYI 2384
Score = 97.8 bits (242), Expect = 3e-20
Identities = 111/405 (27%), Positives = 176/405 (43%), Gaps = 43/405 (10%)
Query: 99 DLFIINENTGDIQATKRLDREEKPVYILRAQAINRRT----GRPVEPESEFIIKIHDIND 154
DLF ++ +G I + RL+ +EK Y L A++R V ++ + I IN+
Sbjct: 202 DLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINE 261
Query: 155 NEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP---YFSVE 211
+ P T V T + T+ V VT D DD G V SI+ G P +F +
Sbjct: 262 HAP--TIHVVTHVPFSLEKEPTYAV-VTVDDLDDGANGEIESV--SIVAGDPLDQFFLAK 316
Query: 212 SETGIIKTALLNMDRENREQ----YQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPR 267
+ + + + + E Y + +QAKD G S V I + P R
Sbjct: 317 EGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQ-KCSALKAVYIGNPTRDTVPIR 375
Query: 268 FPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEG 327
F + Y E SPPG + +K S E ++EY ++ GE F + + G
Sbjct: 376 FEKEVYDVSISEFSPPGVVVAIVKLSP----EPIDVEYKLSPGEDAVYFKI----NPRSG 427
Query: 328 IITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDV-DEPPVFSKL 386
+I + L+ KK+VY L+V G K A V I +ED D P F +
Sbjct: 428 LIVTARPLNTVKKEVYKLEVTNKE----------GDLK--AQVTISIEDANDHTPEFQQP 475
Query: 387 AYILQIREDAQINTTIGSVTAQDPDAARNP-VKYSVDRHTDMDRIFNIDSGNGSIFTSKL 445
Y + E + T++ +V+A D D N + YS+ + F I+ G I T++
Sbjct: 476 LYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP--FVINQFTGVISTTEE 533
Query: 446 LDRETL-LWHNITVIATEINNP-KQSSRVPLYIKVLDVNDNAPEF 488
LD E+ + V A++ +P + S V + I++ +VNDN+P F
Sbjct: 534 LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLF 578
Score = 90.5 bits (223), Expect = 5e-18
Identities = 119/489 (24%), Positives = 203/489 (41%), Gaps = 53/489 (10%)
Query: 61 FLLEEYTGSDYQYVGKLHS-------DQDRGDGS-LKYILSGDGA---GDLFIINENTGD 109
F+ EY S VG+ H D D G S + Y L + + DL I+ + G
Sbjct: 2600 FMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGW 2659
Query: 110 IQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNE--PIFTKEVYTAT 167
+ ++ + V +A++ G PV+ S + IH + P FT+ Y+ T
Sbjct: 2660 MVTKGNFNQLKNTVLSFFVKAVDG--GIPVK-HSLIPVYIHVLPPETFLPSFTQSQYSFT 2716
Query: 168 VPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQP-------YFSVESETGIIKTA 220
+ E + +G+ V D S V +S + G+ F +E ETG IK
Sbjct: 2717 IAEDTAIGSTV--------DTLRILPSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLD 2768
Query: 221 LLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPES 280
+DRE + + A ++ + T V+I + D+NDN P F S+Y E
Sbjct: 2769 K-RLDRETSPAFHFKVAATIPLDKVD-IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEG 2826
Query: 281 SPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKK 340
P GT + +++A D D G N ++ YS+ + + ++ G I+ K LD E
Sbjct: 2827 MPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETD 2886
Query: 341 KVYTLKVEASNPYVEPRFLYLG---PFKDSATVRIVVEDV-DEPPVFSKLAYILQIREDA 396
+T V AS+ LG +A V + V D+ D PVF++ Y ++E
Sbjct: 2887 PTFTFSVVASD---------LGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESD 2937
Query: 397 QINTTIGSVTAQDPDAA--RNPVKYSVDRHTDMDRI-FNIDSGNGSIFTSKLLDRETLLW 453
+ ++ D D + V Y + R + ++ + LDRE
Sbjct: 2938 PPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDI 2997
Query: 454 HNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEF-YETFVCEKAKADQLIQTLHAV 512
+ + + AT+ Q+ + + V DVNDN+P + Y + E ++++I + A
Sbjct: 2998 YFLNITATDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAK 3054
Query: 513 DKDDPYSGH 521
D D +G+
Sbjct: 3055 DADIGSNGY 3063
Score = 84.0 bits (206), Expect = 5e-16
Identities = 67/209 (32%), Positives = 105/209 (50%), Gaps = 10/209 (4%)
Query: 91 ILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFI-IKI 149
I++GD + F ++ G ++ K+LDRE Y L QA++ +G P + + I I
Sbjct: 3380 IVNGDRDNE-FTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD--SGIPAMSSTATVNIDI 3436
Query: 150 HDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFS 209
D+NDN P+FT YTA + E VGT ++Q+ TD D ++ N +SIL G
Sbjct: 3437 SDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRD--SFHNGPPFSFSILSGNEEEE 3494
Query: 210 -VESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRF 268
V GI+++A++ E+ E Y + +QAKD G+ +S T + + P
Sbjct: 3495 FVLDPHGILRSAVVFQHTESLE-YVLCVQAKD-SGKPQQVSHTYIRVRVIEESTHKPTAI 3552
Query: 269 PQSTYQFKTPESSPPGTPIGRIKASDADV 297
P + T E PG IG+I A+D D+
Sbjct: 3553 PLEIF-IVTMEDDFPGGVIGKIHATDQDM 3580
Score = 73.9 bits (180), Expect = 5e-13
Identities = 85/340 (25%), Positives = 147/340 (43%), Gaps = 53/340 (15%)
Query: 159 FTKEVYTATVPEMSDVGTFV-----VQVTATDADDPTYGNSAKVVYSILQGQPYFSVESE 213
FT +Y ATV E S T+V + +T D S + Y I+ G ++E
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDL-------SWDIKYRIVSGDEEGFFKAE 95
Query: 214 TGII-------------KTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTD 260
II +A+LN RE ++ Y ++++ G L T VNI + D
Sbjct: 96 EVIIADFCFLRIRTKGGNSAILN--REIQDNYLLIVKGSVRGED---LEAWTKVNIQVLD 150
Query: 261 VNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVIT 320
+ND P F +TY ES+P T + ++ A+DAD+G N E Y + +D+F V
Sbjct: 151 MNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKN--KVDLFSV-- 206
Query: 321 DQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVV--EDVD 378
G+I++ L++++K Y L++ A V+ G S+T ++ V E ++
Sbjct: 207 --HPTSGVISLSGRLNYDEKNRYDLEILA----VDRGMKLYGNNGVSSTAKLYVHIERIN 260
Query: 379 EPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNP--VKYSVDRHTDMDRIFNIDSG 436
E + + + + T VT D D N S+ +D+ F G
Sbjct: 261 EHA--PTIHVVTHVPFSLEKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEG 318
Query: 437 NGSIFTSKLLDRETLLW------HNITVIATEINNPKQSS 470
+ K+ +R+ + W +N+T+ A + +P++ S
Sbjct: 319 KW-LNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCS 357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,133,586
Number of Sequences: 37866
Number of extensions: 1392979
Number of successful extensions: 7738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2653
Number of HSP's gapped (non-prelim): 774
length of query: 790
length of database: 18,247,518
effective HSP length: 110
effective length of query: 680
effective length of database: 14,082,258
effective search space: 9575935440
effective search space used: 9575935440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.