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Search of human proteins with 4759276
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo s... 951 0.0
gi|113865883 WD repeat domain 38 [Homo sapiens] 99 6e-21
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 99 1e-20
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 99 1e-20
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 99 1e-20
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 92 8e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 92 8e-19
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 1e-17
gi|16554629 WD repeat domain 5 [Homo sapiens] 86 7e-17
gi|16554627 WD repeat domain 5 [Homo sapiens] 86 7e-17
gi|157266266 WD repeat domain 86 [Homo sapiens] 85 1e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 84 3e-16
gi|23199987 WD repeat domain 5B [Homo sapiens] 82 8e-16
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 82 1e-15
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 81 2e-15
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 80 4e-15
gi|26665869 WD repeat domain 51B [Homo sapiens] 80 4e-15
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 79 7e-15
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 79 7e-15
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 79 9e-15
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 78 2e-14
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 78 2e-14
gi|19913369 transducin beta-like 3 [Homo sapiens] 77 3e-14
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 77 3e-14
gi|72534670 phospholipase A2-activating protein [Homo sapiens] 76 8e-14
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 75 1e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 75 2e-13
gi|32189425 WD repeat domain 69 [Homo sapiens] 75 2e-13
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 74 2e-13
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 74 3e-13
>gi|4759276 RNA, U3 small nucleolar interacting protein 2 [Homo
sapiens]
Length = 475
Score = 951 bits (2459), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP 60
MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP
Sbjct: 1 MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAP 60
Query: 61 RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR 120
RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR
Sbjct: 61 RKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQR 120
Query: 121 GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK 180
GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK
Sbjct: 121 GRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK 180
Query: 181 LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH 240
LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH
Sbjct: 181 LHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGH 240
Query: 241 RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA 300
RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA
Sbjct: 241 RDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTA 300
Query: 301 GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL 360
GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL
Sbjct: 301 GGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLAL 360
Query: 361 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL 420
QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL
Sbjct: 361 QREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL 420
Query: 421 VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS 475
VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS
Sbjct: 421 VGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS 475
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 99.4 bits (246), Expect = 6e-21
Identities = 73/319 (22%), Positives = 134/319 (42%), Gaps = 32/319 (10%)
Query: 134 PASADIRVLR---GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKG 190
PA+ +R ++ H + +PD + + ++D + W SG+ L +
Sbjct: 6 PATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG----- 60
Query: 191 AEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFR 250
GH+ V S DG AS + +W+ + L GH+ +V ++F
Sbjct: 61 ------GHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
Query: 251 RGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
+ QL S D+ V +W+V + L GH+D++ + D C+ G D TV +W
Sbjct: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Query: 311 KI----PEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHG 366
+ P S GH +I C+ + SG+ D ++ +W + L +Q + H
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS-SLLIQLKGH- 232
Query: 367 LRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINS 426
W+ S+A + +A+ +S V++W C G + L+ L + + ++
Sbjct: 233 ---------VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTG-KCLETLKGV--LDVAHT 280
Query: 427 LKFSSSGDFLVAGVGQEHR 445
F+ G LV+G + R
Sbjct: 281 CAFTPDGKILVSGAADQTR 299
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 98.6 bits (244), Expect = 1e-20
Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH
Sbjct: 336 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 382
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
+ V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S
Sbjct: 383 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 438
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L
Sbjct: 439 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 496
Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352
G HQ ++ C+ N+ +++ +DDG+V LW L
Sbjct: 497 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 533
Score = 77.0 bits (188), Expect = 3e-14
Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH HV+ + G + SG + +W A + + L T GH V R +
Sbjct: 260 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 316
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR++KVWN + TL+GH V + E V +G RD T+RVW I
Sbjct: 317 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 374
Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375
L V GH ++ C+ + +VSGA D V +W + L H L+G
Sbjct: 375 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 427
Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408
+ V +GS + +R+W G
Sbjct: 428 SLQFDGIH-------VVSGSLDTSIRVWDVETG 453
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 98.6 bits (244), Expect = 1e-20
Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH
Sbjct: 454 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 500
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
+ V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S
Sbjct: 501 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 556
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L
Sbjct: 557 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 614
Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352
G HQ ++ C+ N+ +++ +DDG+V LW L
Sbjct: 615 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 651
Score = 77.0 bits (188), Expect = 3e-14
Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH HV+ + G + SG + +W A + + L T GH V R +
Sbjct: 378 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 434
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR++KVWN + TL+GH V + E V +G RD T+RVW I
Sbjct: 435 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 492
Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375
L V GH ++ C+ + +VSGA D V +W + L H L+G
Sbjct: 493 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 545
Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408
+ V +GS + +R+W G
Sbjct: 546 SLQFDGIH-------VVSGSLDTSIRVWDVETG 571
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 98.6 bits (244), Expect = 1e-20
Identities = 62/218 (28%), Positives = 112/218 (51%), Gaps = 24/218 (11%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
I L GH ++ C+ + + + S ++D ++ W +E+G+ LHV+ GH
Sbjct: 374 IHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVL-----------MGH 420
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
+ V C + DG+ + SG ++ +W+ ++ L+T GH + V L F G H + S
Sbjct: 421 VAAVRC--VQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIH-VVS 476
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
S D S++VW+V + + TL GHQ + ++ ++ + +G D TV++W I L
Sbjct: 477 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCL 534
Query: 319 -VFYG---HQGSIDCIHLINEEHMVSGADDGSVALWGL 352
G HQ ++ C+ N+ +++ +DDG+V LW L
Sbjct: 535 QTLQGPNKHQSAVTCLQ-FNKNFVITSSDDGTVKLWDL 571
Score = 77.0 bits (188), Expect = 3e-14
Identities = 60/213 (28%), Positives = 88/213 (41%), Gaps = 20/213 (9%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH HV+ + G + SG + +W A + + L T GH V R +
Sbjct: 298 GHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--I 354
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR++KVWN + TL+GH V + E V +G RD T+RVW I
Sbjct: 355 ISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQ 412
Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQ 375
L V GH ++ C+ + +VSGA D V +W + L H L+G
Sbjct: 413 CLHVLMGHVAAVRCVQ-YDGRRVVSGAYDFMVKVWDPETETCL------HTLQGHTNRVY 465
Query: 376 PFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408
+ V +GS + +R+W G
Sbjct: 466 SLQFDGIH-------VVSGSLDTSIRVWDVETG 491
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 92.4 bits (228), Expect = 8e-19
Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
R+L GH S+ CL D+ I + + D ++ W V +G L+ + H
Sbjct: 301 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----------HC 347
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY---TFTGHRDAVSGLAFRRGTHQL 256
VL + ++ S DRS I +W+ S + GHR AV+ + F +
Sbjct: 348 EAVLHLRFNNGMMVTCSKDRS--IAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYI 403
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR++KVWN + +V TL GH+ +A L R+ V +G D T+R+W I +
Sbjct: 404 VSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGA 461
Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352
L V GH+ + CI N + +VSGA DG + +W L
Sbjct: 462 CLRVLEGHEELVRCIRFDN-KRIVSGAYDGKIKVWDL 497
Score = 62.0 bits (149), Expect = 1e-09
Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 28/222 (12%)
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
S V C+ D + + SG R I IW+ + + TGH +V L + + +
Sbjct: 267 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIIT 322
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
S D +V+VW+V + TL H +AV L + VT +D ++ VW + + +
Sbjct: 323 GSSDSTVRVWDVNTGEMLNTLIHHCEAVLHL-RFNNGMMVTC-SKDRSIAVWDMASPTDI 380
Query: 319 ----VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374
V GH+ +++ + +++++VS + D ++ +W S R +G +
Sbjct: 381 TLRRVLVGHRAAVNVVD-FDDKYIVSASGDRTIKVWNTS---TCEFVRTLNGHK------ 430
Query: 375 QPFWISSVAALLNTD-LVATGSHSSCVRLW--QCGEGFRQLD 413
+A L D LV +GS + +RLW +CG R L+
Sbjct: 431 -----RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE 467
Score = 46.6 bits (109), Expect = 5e-05
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 26/140 (18%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+R L GH+ I CL D + S + D +I W +E G L V+ GH
Sbjct: 423 VRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLE-----------GH 469
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH---------LYTFTGHRDAVSGLAF 249
V C I D K + SG I +W+ + L T H V L F
Sbjct: 470 EELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 527
Query: 250 RRGTHQLYSTSHDRSVKVWN 269
Q+ S+SHD ++ +W+
Sbjct: 528 DE--FQIVSSSHDDTILIWD 545
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 92.4 bits (228), Expect = 8e-19
Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 24/217 (11%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
R+L GH S+ CL D+ I + + D ++ W V +G L+ + H
Sbjct: 337 RILTGHTGSVLCLQY--DERVIITGSSDSTVRVWDVNTGEMLNTLIH-----------HC 383
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLY---TFTGHRDAVSGLAFRRGTHQL 256
VL + ++ S DRS I +W+ S + GHR AV+ + F +
Sbjct: 384 EAVLHLRFNNGMMVTCSKDRS--IAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYI 439
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR++KVWN + +V TL GH+ +A L R+ V +G D T+R+W I +
Sbjct: 440 VSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDRLVVSGSSDNTIRLWDIECGA 497
Query: 317 QL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352
L V GH+ + CI N + +VSGA DG + +W L
Sbjct: 498 CLRVLEGHEELVRCIRFDN-KRIVSGAYDGKIKVWDL 533
Score = 62.0 bits (149), Expect = 1e-09
Identities = 56/222 (25%), Positives = 100/222 (45%), Gaps = 28/222 (12%)
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
S V C+ D + + SG R I IW+ + + TGH +V L + + +
Sbjct: 303 SKGVYCLQY--DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIIT 358
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
S D +V+VW+V + TL H +AV L + VT +D ++ VW + + +
Sbjct: 359 GSSDSTVRVWDVNTGEMLNTLIHHCEAVLHL-RFNNGMMVTC-SKDRSIAVWDMASPTDI 416
Query: 319 ----VFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374
V GH+ +++ + +++++VS + D ++ +W S R +G +
Sbjct: 417 TLRRVLVGHRAAVNVVD-FDDKYIVSASGDRTIKVWNTS---TCEFVRTLNGHK------ 466
Query: 375 QPFWISSVAALLNTD-LVATGSHSSCVRLW--QCGEGFRQLD 413
+A L D LV +GS + +RLW +CG R L+
Sbjct: 467 -----RGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLE 503
Score = 46.6 bits (109), Expect = 5e-05
Identities = 39/140 (27%), Positives = 56/140 (40%), Gaps = 26/140 (18%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+R L GH+ I CL D + S + D +I W +E G L V+ GH
Sbjct: 459 VRTLNGHKRGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLE-----------GH 505
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH---------LYTFTGHRDAVSGLAF 249
V C I D K + SG I +W+ + L T H V L F
Sbjct: 506 EELVRC--IRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQF 563
Query: 250 RRGTHQLYSTSHDRSVKVWN 269
Q+ S+SHD ++ +W+
Sbjct: 564 DE--FQIVSSSHDDTILIWD 581
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 88.6 bits (218), Expect = 1e-17
Identities = 98/407 (24%), Positives = 162/407 (39%), Gaps = 65/407 (15%)
Query: 54 ESESLAPRKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLK 113
E+ S+ ++ E + EEL++ L K + +R Q+ + E + K
Sbjct: 26 EAYSVFKKEAELDVNEELDKKYAGL---LEKKWTSVIRLQK------KVMELESKLNEAK 76
Query: 114 EDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKW 173
E+ QK KE P + L GH+ +T ++ P S + SA++D +I W
Sbjct: 77 EEFTSGGPLGQKRDPKE-WIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVW 135
Query: 174 SVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQH 233
E+G E GH+ V ++ GK LAS I +W+ Q +
Sbjct: 136 DYETG-----------DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFEC 184
Query: 234 LYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALS 293
+ T GH VS +A + S S D+++K+W V V+T GH++ V +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 294 RECCVTAGGRDGTVRVWKI-PEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGL 352
+ + D TVRVW + +E + H+ ++CI E S S A
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE----SSYSSISEATGSE 300
Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412
+KK G+PG PF +S GS +++W G
Sbjct: 301 TKK------------SGKPG---PFLLS-------------GSRDKTIKMWDVSTG---- 328
Query: 413 DLLCDIPLVG---FINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEAR 456
+C + LVG ++ + F S G F+++ + + R W K R
Sbjct: 329 --MCLMTLVGHDNWVRGVLFHSGGKFILSCA--DDKTLRVWDYKNKR 371
Score = 70.9 bits (172), Expect = 2e-12
Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 51/224 (22%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESG-------------------- 178
IR + GH +++ + + P+ I SA++D +I W V++G
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQ 244
Query: 179 -----------RKLHVIPRAKKGAEGKPPGHSSHVLCMAISSD----------------- 210
+ + V A K + + H V C++ + +
Sbjct: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
Query: 211 ---GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKV 267
G +L SG R K I +W+ + L T GH + V G+ F G + S + D++++V
Sbjct: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
Query: 268 WNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311
W+ ++TL H+ V +LD V G D TV+VW+
Sbjct: 365 WDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 17/222 (7%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
+ + GH+L I+ + + D + + SA+ D ++ W V SG+ L + GHS
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------GHS 129
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
++V C + + SG + + IW+ ++ + L T H D VS + F R + S+
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318
S+D ++W+ A ++TL + + S + A D T+++W + L
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355
Y GH+ CI + + +VSG++D V +W L K
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291
Score = 79.0 bits (193), Expect = 9e-15
Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH+ V + S +G++LAS KLI IW A + T +GH+ +S +A+ ++ L
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S D+++K+W+V+ ++TL GH + V + + + +G D +VR+W +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 317 QL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALW 350
L H + +H + + VS + DG +W
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 68.9 bits (167), Expect = 9e-12
Identities = 53/220 (24%), Positives = 93/220 (42%), Gaps = 14/220 (6%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
L GH +++ + +P+ + S++ D I W G+ E GH
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----------FEKTISGHKLG 89
Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
+ +A SSD L S K + IW+ S + L T GH + V F ++ + S S
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--V 319
D SV++W+V ++TL H D V+A+ + + DG R+W L +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 320 FYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPL 358
+ + N +++++ D ++ LW SK + L
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Score = 68.6 bits (166), Expect = 1e-11
Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 17/207 (8%)
Query: 235 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 294
+T GH AVS + F L S+S D+ +K+W + + +T+ GH+ ++ + S
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 295 ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGL 352
+ + D T+++W + L GH + C + + ++ VSG+ D SV +W +
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412
+ L+ P P +S+V + L+ + S+ R+W G
Sbjct: 159 ---------KTGKCLKTLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 413 DLL-CDIPLVGFINSLKFSSSGDFLVA 438
L+ D P V F+ KFS +G +++A
Sbjct: 208 TLIDDDNPPVSFV---KFSPNGKYILA 231
Score = 63.5 bits (153), Expect = 4e-10
Identities = 49/220 (22%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
++ L+GH + C P + I S + D S+ W V++G+ L + P H
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-----------PAH 170
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT-FTGHRDAVSGLAFRRGTHQLY 257
S V + + DG + S L IW+ S Q L T VS + F +
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313
+ + D ++K+W+ ++ ++T GH++ + A +++ + +G D V +W +
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350
+E GH + E++++ A +D ++ LW
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 85.9 bits (211), Expect = 7e-17
Identities = 56/222 (25%), Positives = 102/222 (45%), Gaps = 17/222 (7%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
+ + GH+L I+ + + D + + SA+ D ++ W V SG+ L + GHS
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-----------GHS 129
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
++V C + + SG + + IW+ ++ + L T H D VS + F R + S+
Sbjct: 130 NYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318
S+D ++W+ A ++TL + + S + A D T+++W + L
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355
Y GH+ CI + + +VSG++D V +W L K
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 291
Score = 79.0 bits (193), Expect = 9e-15
Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH+ V + S +G++LAS KLI IW A + T +GH+ +S +A+ ++ L
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S D+++K+W+V+ ++TL GH + V + + + +G D +VR+W +
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
Query: 317 QL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALW 350
L H + +H + + VS + DG +W
Sbjct: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 68.9 bits (167), Expect = 9e-12
Identities = 53/220 (24%), Positives = 93/220 (42%), Gaps = 14/220 (6%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
L GH +++ + +P+ + S++ D I W G+ E GH
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-----------FEKTISGHKLG 89
Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
+ +A SSD L S K + IW+ S + L T GH + V F ++ + S S
Sbjct: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL--V 319
D SV++W+V ++TL H D V+A+ + + DG R+W L +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
Query: 320 FYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPL 358
+ + N +++++ D ++ LW SK + L
Sbjct: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Score = 68.6 bits (166), Expect = 1e-11
Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 17/207 (8%)
Query: 235 YTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSR 294
+T GH AVS + F L S+S D+ +K+W + + +T+ GH+ ++ + S
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 295 ECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGL 352
+ + D T+++W + L GH + C + + ++ VSG+ D SV +W +
Sbjct: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 353 SKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQL 412
+ L+ P P +S+V + L+ + S+ R+W G
Sbjct: 159 ---------KTGKCLKTLPAHSDP--VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 413 DLL-CDIPLVGFINSLKFSSSGDFLVA 438
L+ D P V F+ KFS +G +++A
Sbjct: 208 TLIDDDNPPVSFV---KFSPNGKYILA 231
Score = 63.5 bits (153), Expect = 4e-10
Identities = 49/220 (22%), Positives = 95/220 (43%), Gaps = 19/220 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
++ L+GH + C P + I S + D S+ W V++G+ L + P H
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL-----------PAH 170
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYT-FTGHRDAVSGLAFRRGTHQLY 257
S V + + DG + S L IW+ S Q L T VS + F +
Sbjct: 171 SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313
+ + D ++K+W+ ++ ++T GH++ + A +++ + +G D V +W +
Sbjct: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350
+E GH + E++++ A +D ++ LW
Sbjct: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 85.1 bits (209), Expect = 1e-16
Identities = 67/225 (29%), Positives = 103/225 (45%), Gaps = 31/225 (13%)
Query: 141 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200
+L+GH+ +T + +D A F+ + DC+I +W V +G+ L V GH+S
Sbjct: 52 LLQGHESYVTFCQL--EDEAAFTCSADCTIRRWDVLTGQCLQVY-----------RGHTS 98
Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF----------- 249
V + ++++ + +S DR+ +W Q F GHR+ V LA+
Sbjct: 99 IVNRILVANNQLFSSSYDRT--ARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPC 156
Query: 250 ---RRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGT 306
L + S D + KVW VA +TL GH AV L + G D T
Sbjct: 157 AEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDAT 216
Query: 307 VRVWKIPEESQL-VFYGHQGSIDCIHLINEEHMVSGADDGSVALW 350
+R W I QL VF H+GS+ C+ L+N + SG+ D +V W
Sbjct: 217 IRAWDILSGEQLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW 260
Score = 82.4 bits (202), Expect = 8e-16
Identities = 68/286 (23%), Positives = 116/286 (40%), Gaps = 44/286 (15%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+RV H+ I L ++PD + + ++D + WS G+ ++ GH
Sbjct: 8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALL-----------QGH 56
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
S+V + + + S D + I W+ + Q L + GH V+ + +QL+S
Sbjct: 57 ESYVTFCQLEDEAAFTCSADCT--IRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFS 112
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAAL------DALSRECC--------VTAGGRD 304
+S+DR+ +VW+V + GH++ V L D S C + G D
Sbjct: 113 SSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTD 172
Query: 305 GTVRVWKIPEE-SQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLALQR 362
GT +VW++ GH G++ C+ L H +G+ D ++ W + L + R
Sbjct: 173 GTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
Query: 363 EAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEG 408
E G S + L LV +GS V+ W G
Sbjct: 233 EHRG-------------SVICLELVNRLVYSGSADRTVKCWLADTG 265
Score = 65.9 bits (159), Expect = 8e-11
Identities = 46/185 (24%), Positives = 78/185 (42%), Gaps = 17/185 (9%)
Query: 128 AKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRA 187
AK Q + + LRGH ++ CLV+ F+ + D +I W + SG +L V
Sbjct: 175 AKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFRE- 233
Query: 188 KKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGL 247
H V+C+ + + Y S DR+ + W A + + + TFT HR VS L
Sbjct: 234 ----------HRGSVICLELVNRLVYSGSADRT--VKCWLADTGECVRTFTAHRRNVSAL 281
Query: 248 AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTV 307
+ GT L++ S D + ++ GH + + + + DG +
Sbjct: 282 KYHAGT--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVHGQ--VLYTASHDGAL 337
Query: 308 RVWKI 312
R+W +
Sbjct: 338 RLWDV 342
Score = 57.0 bits (136), Expect = 4e-08
Identities = 60/282 (21%), Positives = 106/282 (37%), Gaps = 71/282 (25%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEG----- 193
++V RGH + ++V ++ +FS++ D + WSV+ G+ + R +G
Sbjct: 90 LQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQ----MSREFRGHRNCVLTL 143
Query: 194 --KPPGHSSHVLCMAISSDGKYLASGDRSKLILIWE-AQSCQHLYTFTGHRDAVSGLAFR 250
P C ++ G L +G +W+ A C H T GH AV L
Sbjct: 144 AYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCH-QTLRGHTGAVLCLVLD 202
Query: 251 RGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
H ++ S D +++ W++ + H+ +V L+ ++R V +G D TV+ W
Sbjct: 203 TPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNR--LVYSGSADRTVKCW 260
Query: 311 KIPE-----------------------------------------ESQLVFYGHQGSIDC 329
E + VF GH I+C
Sbjct: 261 LADTGECVRTFTAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRRVFRGHTFIINC 320
Query: 330 IHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371
I ++ + + + + DG++ LW + GLRG P
Sbjct: 321 IQ-VHGQVLYTASHDGALRLW------------DVRGLRGAP 349
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 84.0 bits (206), Expect = 3e-16
Identities = 101/438 (23%), Positives = 162/438 (36%), Gaps = 46/438 (10%)
Query: 10 RGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAPRKPEEEEEE 69
R K A G+ AG+ +R+A+ + K+ + + E E P E+EE E
Sbjct: 347 RSKQQIDAMVGSLAGEAKREANKS----------KVFFGLLKEPEIE--VPLDDEDEEGE 394
Query: 70 ELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAK 129
E ++KK + + + +Q + R + + ++ + +++
Sbjct: 395 NEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLG 454
Query: 130 EIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSV-------------- 175
P+ L +Q +T + VT D S I D ++ WSV
Sbjct: 455 PDCLPSICFYTFLNAYQ-GLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDL 513
Query: 176 -----ESGRKLHVIPRAKKGAEGKPP-GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQ 229
ES L I K +E K GHS V + S D YL S + +W Q
Sbjct: 514 SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ 573
Query: 230 SCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAAL 289
+ L + GH V F + S HDR ++W + GH V
Sbjct: 574 TFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCT 633
Query: 290 DALSRECCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLI-NEEHMVSGADDGSV 347
V G D TVR+W + + + +F GH+G I + N + +GA DG V
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 348 ALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGE 407
LW + HGL + S+ + +++A+GS + VRLW +
Sbjct: 694 LLWDIG-----------HGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Query: 408 GFRQLDLLCDIPLVGFIN 425
F L+ G IN
Sbjct: 743 AFEDLETDDFTTATGHIN 760
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 82.4 bits (202), Expect = 8e-16
Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 17/222 (7%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
+ L GH L I+ + + D S + SA+ D ++ W V SG+ L + GHS
Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK-----------GHS 125
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
++V C + + SG + + IWE ++ + L T + H D VS + F + S
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185
Query: 260 SHDRSVKVWNVAENSYVETLFGHQDAVAALDALS-RECCVTAGGRDGTVRVWKIPEESQL 318
S+D ++W+ A ++TL + + S + D T+++W L
Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245
Query: 319 VFY-GHQGSIDCI----HLINEEHMVSGADDGSVALWGLSKK 355
Y GH+ CI + + +VSG++D V +W L K
Sbjct: 246 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 287
Score = 78.6 bits (192), Expect = 1e-14
Identities = 44/156 (28%), Positives = 79/156 (50%), Gaps = 2/156 (1%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH+ V + S +G++LAS +LI+IW A ++ T GH +S +A+ + +L
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S D+++K+W+V ++TL GH + V + + +G D TV++W++
Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
Query: 317 QL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALW 350
L H + +H + +VSG+ DG +W
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 72.8 bits (177), Expect = 6e-13
Identities = 46/169 (27%), Positives = 77/169 (45%), Gaps = 11/169 (6%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
L GH +++ + +P+ + S++ D II W G+ E GH+
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK-----------YEKTLYGHNLE 85
Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
+ +A SSD L S K + +W+ +S + L T GH + V F ++ + S S
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVW 310
D +VK+W V ++TL H D V+A+ + +G DG R+W
Sbjct: 146 DETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 65.9 bits (159), Expect = 8e-11
Identities = 50/205 (24%), Positives = 92/205 (44%), Gaps = 17/205 (8%)
Query: 236 TFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRE 295
T GH +AVS + F L S+S DR + +W + Y +TL+GH ++ + S
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 296 CCVTAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLS 353
+ + D T+++W + L GH + C + ++ +SG+ D +V +W +
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 354 KKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLD 413
+ L + +P +S+V + L+ +GS+ R+W G
Sbjct: 156 TGKCL----KTLSAHSDP-------VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 414 LL-CDIPLVGFINSLKFSSSGDFLV 437
L+ D P V F+ KFS +G +++
Sbjct: 205 LVDDDNPPVSFV---KFSPNGKYIL 226
Score = 60.8 bits (146), Expect = 3e-09
Identities = 48/220 (21%), Positives = 94/220 (42%), Gaps = 19/220 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
++ L+GH + C P + I S + D ++ W V++G+ L + H
Sbjct: 118 LKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL-----------SAH 166
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT-GHRDAVSGLAFRRGTHQLY 257
S V + + G + SG L IW+A S Q L T VS + F +
Sbjct: 167 SDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL 226
Query: 258 STSHDRSVKVWNVAENSYVETLFGHQD---AVAALDALSRECCVTAGGRDGTVRVWKI-P 313
+ + D ++K+W+ + ++T GH++ + A +++ + +G D V +W +
Sbjct: 227 TATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 286
Query: 314 EESQLVFYGHQGSIDCIHLINEEHMVSGA---DDGSVALW 350
+E GH + E++++ A +D ++ LW
Sbjct: 287 KEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 81.6 bits (200), Expect = 1e-15
Identities = 83/305 (27%), Positives = 133/305 (43%), Gaps = 34/305 (11%)
Query: 163 SAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKL 222
SA++D ++ W + + H G E + GH V C + S+DG LA+G R +
Sbjct: 2027 SASEDFTVQLWPRQLLTRPHKAEDFPCGTELR--GHEGPVSCCSFSTDGGSLATGGRDRS 2084
Query: 223 ILIWEAQSCQH---LYTFTG-HRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVET 278
+L W+ ++ + +++F HRD V+G A+ + + L S S D SV +W+ +
Sbjct: 2085 LLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTK-DNLLISCSSDGSVGLWDPESGQRLGQ 2143
Query: 279 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSID-CIHLI---- 333
GHQ AV+A+ A+ V + RDGT++VW H G I C +
Sbjct: 2144 FLGHQSAVSAVAAVEEH--VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRA 2201
Query: 334 -----NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNT 388
+E +V+ DG+ LW PL L + H L G G + + A +
Sbjct: 2202 AGQPGSELLVVTVGLDGATRLW-----HPL-LVCQTHTLLGHSGP-----VRAAAVSETS 2250
Query: 389 DLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGR 448
L+ T S VRLWQ ++ D C + ++ ++ G V+G Q L
Sbjct: 2251 GLMLTASEDGSVRLWQVP---KEADDTCIPRSSAAVTAVAWAPDGSMAVSG-NQAGELIL 2306
Query: 449 WWRIK 453
W K
Sbjct: 2307 WQEAK 2311
Score = 65.9 bits (159), Expect = 8e-11
Identities = 72/321 (22%), Positives = 132/321 (41%), Gaps = 45/321 (14%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
LRGH+ ++C + D ++ + +D S++ W V + P+ P H
Sbjct: 2057 LRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRT-------PKTPVLIHSFPACHRDW 2109
Query: 202 VLCMAISSDGKYLA-SGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
V A + D ++ S D S + +W+ +S Q L F GH+ AVS +A + S S
Sbjct: 2110 VTGCAWTKDNLLISCSSDGS--VGLWDPESGQRLGQFLGHQSAVSAVA--AVEEHVVSVS 2165
Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVA---------ALDALSRECCVTAGGRDGTVRVWK 311
D ++KVW+ + + ++ H ++ A E V G DG R+W
Sbjct: 2166 RDGTLKVWD-HQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWH 2224
Query: 312 IPEESQL-VFYGHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKKR-PLALQREAHGLR 368
Q GH G + + M++ ++DGSV LW + K+ + R +
Sbjct: 2225 PLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAA-- 2282
Query: 369 GEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLK 428
+++VA + + +G+ + + LWQ + + G I +L
Sbjct: 2283 ----------VTAVAWAPDGSMAVSGNQAGELILWQ------EAKAVATAQAPGHIGALI 2326
Query: 429 FSSSGDFLVAGVGQEHRLGRW 449
+SS+ F V + + ++ W
Sbjct: 2327 WSSAHTFFV--LSADEKISEW 2345
Score = 44.3 bits (103), Expect = 2e-04
Identities = 80/362 (22%), Positives = 139/362 (38%), Gaps = 36/362 (9%)
Query: 85 LYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL-- 142
+YL LR +EEK+ + L +D L L ++Q RVL
Sbjct: 1700 VYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLLELWDLQHGC----RVLQT 1755
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKL--HVIPRAKKGAEGKPPGHSS 200
+ HQ IT ++PD + + + W G+ H P++
Sbjct: 1756 KAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLN----------- 1804
Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
C+A +G+ +A+G + I ++ + ++ LAF +
Sbjct: 1805 ---CVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR 1861
Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVF 320
D V++W E + + H VAA L C + G DG V+VW S
Sbjct: 1862 LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVW---SGSLGRP 1918
Query: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWIS 380
GH GS+ ++ V+ + DG G + + + + + G +G G +S
Sbjct: 1919 RGHLGSLS----LSPALSVALSPDGDRVAVGY-RADGIRIYKISSGSQGAQGQALDVAVS 1973
Query: 381 SVAALLNTDLVATGSHSSCVRLWQCGE-GFRQLDLLCDI--PLVGFINS--LKFSSSGDF 435
++ A L+ ++ +G+ ++ W E + L LL P++G S L S+S DF
Sbjct: 1974 AL-AWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDF 2032
Query: 436 LV 437
V
Sbjct: 2033 TV 2034
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 80.9 bits (198), Expect = 2e-15
Identities = 55/209 (26%), Positives = 85/209 (40%), Gaps = 31/209 (14%)
Query: 135 ASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRK-------------L 181
A ++++LRGH + D S + S ++D SI W + S L
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
Query: 182 HVIPRAKKGAEGKP------------------PGHSSHVLCMAISSDGKYLASGDRSKLI 223
+ P + A G GH + V C+ + YLA+G K +
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450
Query: 224 LIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQ 283
+W AQ + FTGHR V LAF L S D+ +K+W++A + + L GH
Sbjct: 451 RLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510
Query: 284 DAVAALDALSRECCVTAGGRDGTVRVWKI 312
D + +L + + D +VRVW I
Sbjct: 511 DNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 68.6 bits (166), Expect = 1e-11
Identities = 37/137 (27%), Positives = 65/137 (47%), Gaps = 12/137 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+R+ GH + C+ P+ + + + + D ++ WS + G + + GH
Sbjct: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF-----------TGH 467
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
VL +A S +GKYLAS + + +W+ S GH D ++ L F + + S
Sbjct: 468 RGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527
Query: 259 TSHDRSVKVWNVAENSY 275
S D SV+VW++ N+Y
Sbjct: 528 ASMDNSVRVWDI-RNTY 543
Score = 60.8 bits (146), Expect = 3e-09
Identities = 62/265 (23%), Positives = 103/265 (38%), Gaps = 33/265 (12%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH V +D L S I W+ S + + GH V L +
Sbjct: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYF 399
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-E 315
S SHDR+ ++W+ + GH V + + G D TVR+W +
Sbjct: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN 459
Query: 316 SQLVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374
S +F GH+G + + N +++ S +D + LW L+ L +E G
Sbjct: 460 SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG---TLYKELRGHTDN---- 512
Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIP-------LVGF---- 423
I+S+ ++ L+A+ S + VR+W + C P LVG
Sbjct: 513 ----ITSLTFSPDSGLIASASMDNSVRVWDIRNTY------CSAPADGSSSELVGVYTGQ 562
Query: 424 ---INSLKFSSSGDFLVAGVGQEHR 445
+ S++F + LV G+ QE++
Sbjct: 563 MSNVLSVQFMACNLLLVTGITQENQ 587
Score = 33.1 bits (74), Expect = 0.57
Identities = 22/76 (28%), Positives = 33/76 (43%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
LRGH +IT L +PD I SA+ D S+ W + + + G G S+
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN 565
Query: 202 VLCMAISSDGKYLASG 217
VL + + L +G
Sbjct: 566 VLSVQFMACNLLLVTG 581
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 80.1 bits (196), Expect = 4e-15
Identities = 62/224 (27%), Positives = 103/224 (45%), Gaps = 14/224 (6%)
Query: 142 LRGHQLSITCLVVTPD-DSAIFSAAKDCSIIKWSVESGRKLHVIP-RAKKGAEGKPPGHS 199
L+GH +T + TP I SA++D +II W + + IP RA +G HS
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRG-------HS 63
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
V + ISSDG++ SG + +W+ + F GH V +AF Q+ S
Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSG 123
Query: 260 SHDRSVKVWN-VAENSYVETLFGHQDAVAAL--DALSRECCVTAGGRDGTVRVWKIPE-E 315
S D+++K+WN + Y H + V+ + S + + G D V+VW + +
Sbjct: 124 SRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK 183
Query: 316 SQLVFYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPL 358
+ GH G ++ + + + + SG DG LW L++ + L
Sbjct: 184 LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHL 227
Score = 79.3 bits (194), Expect = 7e-15
Identities = 63/274 (22%), Positives = 109/274 (39%), Gaps = 16/274 (5%)
Query: 140 RVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHS 199
R LRGH ++ +V++ D S + D ++ W + +G + GH+
Sbjct: 57 RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTR-----------RFVGHT 105
Query: 200 SHVLCMAISSDGKYLASGDRSKLILIWEAQS-CQHLYTFTGHRDAVSGLAFRRGTHQ--L 256
VL +A SSD + + SG R K I +W C++ H + VS + F + +
Sbjct: 106 KDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPII 165
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S D+ VKVWN+A GH + + +GG+DG +W + E
Sbjct: 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGK 225
Query: 317 QLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQP 376
L I+ + + + A S+ +W L K + + + +P
Sbjct: 226 HLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGK--IIVDELKQEVISTSSKAEP 283
Query: 377 FWISSVAALLNTDLVATGSHSSCVRLWQCGEGFR 410
+S+A + + G + VR+WQ G R
Sbjct: 284 PQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 80.1 bits (196), Expect = 4e-15
Identities = 59/263 (22%), Positives = 115/263 (43%), Gaps = 24/263 (9%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ +T + +P + + SA++D ++ W + K+G + H++ V
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPD-----------KRGKFSEFKAHTAPVR 106
Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263
+ S+DG++LA+ K I +W + LY+ H V F + S S D+
Sbjct: 107 SVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDK 166
Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG- 322
++K+W+ V +D C+ + G D TV+VW + L Y
Sbjct: 167 TIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQV 226
Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381
H G ++CI + ++++ + DG++ + L + R + + L+G G + +
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI------YTLQGHTGP-----VFT 275
Query: 382 VAALLNTDLVATGSHSSCVRLWQ 404
V+ +L A+G + V LW+
Sbjct: 276 VSFSKGGELFASGGADTQVLLWR 298
Score = 64.7 bits (156), Expect = 2e-10
Identities = 36/162 (22%), Positives = 74/162 (45%), Gaps = 2/162 (1%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH + + + +S +GK LA+ +++W + Y + GH+D V+ + F + L
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEES 316
S S DR+V++W + H V ++D + + D +++VW + +
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 317 QLV-FYGHQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKR 356
L Y H + C + + VS ++D ++ +W + K+
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ 177
Score = 61.2 bits (147), Expect = 2e-09
Identities = 50/222 (22%), Positives = 92/222 (41%), Gaps = 31/222 (13%)
Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296
F GH+ A++ L QL + S D + +WN ++ GH+D V ++
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 297 CVTAGGRDGTVRVWKIPEESQLV--FYGHQGSIDCIHL-INEEHMVSGADDGSVALWGLS 353
+ + RD TVR+W IP++ F H + + + + + + ++D S+ +W +
Sbjct: 74 LLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY 132
Query: 354 KKRPL-ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW-----QCGE 407
++R L +L R H W+ + L+ + S +++W QC
Sbjct: 133 RQRFLYSLYRHTH------------WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
Query: 408 GFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 449
F VGF N + F+ SG +A G + + W
Sbjct: 181 NFSD--------SVGFANFVDFNPSGT-CIASAGSDQTVKVW 213
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 79.3 bits (194), Expect = 7e-15
Identities = 85/362 (23%), Positives = 142/362 (39%), Gaps = 71/362 (19%)
Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142
L+QLRQ+ E+ +AR D ++ ++ + GR+Q R L
Sbjct: 4 LDQLRQEAEQLKNQIRDARKACADATLSQITNNI-DPVGRIQMRTR-----------RTL 51
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188
RGH I + D + SA++D +I W + K+H IP
Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNY 111
Query: 189 ---------------KGAEGKP------PGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226
K EG GH+ ++ C D + + +SGD + +W
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTT--CALW 169
Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286
+ ++ Q TFTGH V L+ T S + D S K+W+V E +T GH+ +
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229
Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEH----MVSGA 342
A+ G D T R++ + + +L+ Y H I I ++ +++G
Sbjct: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289
Query: 343 DDGSVALWGLSKKRPLALQREAHG-LRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVR 401
DD + +W AL+ + G L G +S + + VATGS S ++
Sbjct: 290 DDFNCNVWD-------ALKADRAGVLAGHDNR-----VSCLGVTDDGMAVATGSWDSFLK 337
Query: 402 LW 403
+W
Sbjct: 338 IW 339
Score = 31.6 bits (70), Expect = 1.6
Identities = 24/130 (18%), Positives = 50/130 (38%), Gaps = 17/130 (13%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ I + P+ +A + + D + + + + ++L +++
Sbjct: 224 GHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSH-------------DNII 270
Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
C ++ S G+ L +G +W+A GH + VS L + +
Sbjct: 271 CGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATG 330
Query: 260 SHDRSVKVWN 269
S D +K+WN
Sbjct: 331 SWDSFLKIWN 340
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 79.3 bits (194), Expect = 7e-15
Identities = 84/361 (23%), Positives = 142/361 (39%), Gaps = 69/361 (19%)
Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142
LEQLRQ+ E+ +AR D ++ L+ GR+Q R L
Sbjct: 4 LEQLRQEAEQLRNQIRDARKACGDSTLTQITAG-LDPVGRIQMRTR-----------RTL 51
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIP----------------- 185
RGH I + D + SA++D +I W + K+H IP
Sbjct: 52 RGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
Query: 186 ------------RAKKGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226
+ K EG + PGH+ ++ C D + + +SGD + +W
Sbjct: 112 VACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTT--CALW 169
Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286
+ ++ Q F GH V L+ S + D S+K+W+V ++ +T GH+ +
Sbjct: 170 DIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDI 229
Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLI----NEEHMVSGA 342
A+ T G D T R++ + + +L+ Y H I I + + +++G
Sbjct: 230 NAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGY 289
Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402
DD + +W + K A H R +S + + VATGS S +++
Sbjct: 290 DDFNCNIWD-AMKGDRAGVLAGHDNR----------VSCLGVTDDGMAVATGSWDSFLKI 338
Query: 403 W 403
W
Sbjct: 339 W 339
Score = 31.2 bits (69), Expect = 2.1
Identities = 26/130 (20%), Positives = 50/130 (38%), Gaps = 17/130 (13%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ I + P+ A + + D + + + + ++L + +++
Sbjct: 224 GHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSH-------------DNII 270
Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
C +A S G+ L +G IW+A GH + VS L + +
Sbjct: 271 CGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATG 330
Query: 260 SHDRSVKVWN 269
S D +K+WN
Sbjct: 331 SWDSFLKIWN 340
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 79.0 bits (193), Expect = 9e-15
Identities = 58/226 (25%), Positives = 106/226 (46%), Gaps = 17/226 (7%)
Query: 137 ADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP 196
A I +L GH+ + C P+ S + SA D I+ W+V + +
Sbjct: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK---------- 106
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV-SGLAFRRGTHQ 255
GHS V+ + ++DG L S K + +W++++ + + GH V S RRG
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQL 166
Query: 256 LYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE 315
+ + S D +VK+W++ + + ++T F + V A+ + +GG D ++VW + +
Sbjct: 167 VCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
Query: 316 S-QLVFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLSKKRPLA 359
GH S+ + L +E +++S A D +V +W + RP A
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV---RPFA 268
Score = 73.6 bits (179), Expect = 4e-13
Identities = 55/228 (24%), Positives = 99/228 (43%), Gaps = 23/228 (10%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
L+GH ++ L D S +FSA+ D ++ W E+G + + R K GH+S
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGER---VKRLK--------GHTSF 153
Query: 202 V-LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
V C + + +G + +W+ + + TF ++ + F + Q+ S
Sbjct: 154 VNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLA-VTFNDTSDQIISGG 212
Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI-----PEE 315
D +KVW++ +N T+ GH D+V L S + + D TVRVW + E
Sbjct: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKER 272
Query: 316 SQLVFYGH-----QGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPL 358
+F G+ + + C + + +G+ D V +W + +R L
Sbjct: 273 CVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Score = 53.5 bits (127), Expect = 4e-07
Identities = 33/122 (27%), Positives = 58/122 (47%), Gaps = 3/122 (2%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
+RGH S+T L ++ + S + S A D ++ W V R R K +G +
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV---RPFAPKERCVKIFQGNVHNFEKN 287
Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
+L + S DG +A+G + + +W+ S + LY GH +++ +AF + S S
Sbjct: 288 LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
Query: 262 DR 263
D+
Sbjct: 348 DK 349
Score = 35.0 bits (79), Expect = 0.15
Identities = 35/162 (21%), Positives = 66/162 (40%), Gaps = 24/162 (14%)
Query: 138 DIR---VLRGHQLSITCLVVTPDDSA--IFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 192
DIR ++ Q + L VT +D++ I S D I W + + + +
Sbjct: 180 DIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR------- 232
Query: 193 GKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEA------QSCQHLYTFTGHRDAVSG 246
GH+ V +++SS+G YL S + +W+ + C ++ H +
Sbjct: 233 ----GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288
Query: 247 L--AFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286
L ++ ++ + S DR V VW+ + L GH ++
Sbjct: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSI 330
Score = 30.8 bits (68), Expect = 2.8
Identities = 30/128 (23%), Positives = 48/128 (37%), Gaps = 13/128 (10%)
Query: 279 LFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEE--SQLVFYGHQGSIDCIHLINEE 336
L GH+ V + + G D + +W + + + GH G++ +H +
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 337 HMV-SGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGS 395
M+ S + D +VA+W L+G F S A LV TGS
Sbjct: 122 SMLFSASTDKTVAVWDSETGE------RVKRLKGHTS----FVNSCYPARRGPQLVCTGS 171
Query: 396 HSSCVRLW 403
V+LW
Sbjct: 172 DDGTVKLW 179
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 77.8 bits (190), Expect = 2e-14
Identities = 83/361 (22%), Positives = 140/361 (38%), Gaps = 69/361 (19%)
Query: 87 LEQLRQQEEEKA----EARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142
LEQLRQ+ E+ +AR D ++ + ++ GR+Q R L
Sbjct: 4 LEQLRQEAEQLRNQIQDARKACNDATLVQITSN-MDSVGRIQMRTR-----------RTL 51
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188
RGH I + D + SA++D +I W + K+H IP
Sbjct: 52 RGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNY 111
Query: 189 ---------------KGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226
K EG + PGH+ ++ C D + + +SGD + +W
Sbjct: 112 VACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTT--CALW 169
Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286
+ ++ Q TFTGH V L+ S + D S K+W++ + ++ GH +
Sbjct: 170 DIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDI 229
Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLI----NEEHMVSGA 342
A+ G D T R++ + + +L+ Y H I I + + +++G
Sbjct: 230 NAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGY 289
Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402
DD + +W + K A H R +S + + VATGS S +R+
Sbjct: 290 DDFNCNVWD-TLKGDRAGVLAGHDNR----------VSCLGVTDDGMAVATGSWDSFLRI 338
Query: 403 W 403
W
Sbjct: 339 W 339
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 77.8 bits (190), Expect = 2e-14
Identities = 56/236 (23%), Positives = 97/236 (41%), Gaps = 14/236 (5%)
Query: 127 VAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPR 186
VA +Q A A+ G + P +A+ S + K S +K +P+
Sbjct: 128 VALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPK 187
Query: 187 AKKGAEGKPP--------GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFT 238
+ PP GH V C+A+ ++ +G + I IW+ S + + T
Sbjct: 188 P----QWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLT 243
Query: 239 GHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCV 298
GH V G+ + L+S D+ VK W++ N + GH AV LD +
Sbjct: 244 GHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVL 303
Query: 299 TAGGRDGTVRVWKIPEESQL-VFYGHQGSIDCIHL-INEEHMVSGADDGSVALWGL 352
RD T R+W + ++ + GH ++ + E +++G+ D ++ LW L
Sbjct: 304 VTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL 359
Score = 77.4 bits (189), Expect = 3e-14
Identities = 50/210 (23%), Positives = 99/210 (47%), Gaps = 13/210 (6%)
Query: 142 LRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSH 201
L GH ++ ++V+ +FS +D + W +E + + GH S
Sbjct: 242 LTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH-----------GHLSA 290
Query: 202 VLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSH 261
V + + L + R IW+ ++ ++T +GH +AV+ + + Q+ + SH
Sbjct: 291 VYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSH 350
Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLV-F 320
D ++++W++ TL H+ +V A+ R +G D ++ WK P+ S +
Sbjct: 351 DTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNL 409
Query: 321 YGHQGSIDCIHLINEEHMVSGADDGSVALW 350
GH I+ + + ++ +VSGAD+G++ LW
Sbjct: 410 SGHNAIINTLTVNSDGVLVSGADNGTMHLW 439
Score = 34.7 bits (78), Expect = 0.19
Identities = 36/180 (20%), Positives = 71/180 (39%), Gaps = 39/180 (21%)
Query: 137 ADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKG------ 190
A + L GH ++ + + I + + D +I W + +G+ + KK
Sbjct: 321 ASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL 380
Query: 191 -------AEGKP-----------------PGHSSHVLCMAISSDGKYLASGDRSKLILIW 226
A G P GH++ + + ++SDG L SG + + +W
Sbjct: 381 HPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGTMHLW 439
Query: 227 EAQSCQ-----HLYTFTGHRDAVSGL---AFRRGTHQLYSTSHDRSVKVWNVAENSYVET 278
+ ++ H G D+ SG+ AF + +L + D+++KV+ + + ET
Sbjct: 440 DWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEET 499
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 77.4 bits (189), Expect = 3e-14
Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 24/208 (11%)
Query: 158 DSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPG-------------HSSHVLC 204
+S + + ++DC++ W +P+A P H +
Sbjct: 434 ESFLVTGSQDCTVKLWP---------LPKALLSKNTAPDNGPILLQAQTTQRCHDKDINS 484
Query: 205 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRS 264
+AI+ + K LA+G + + +W CQ L F+GHR + + F L + S D +
Sbjct: 485 VAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGT 544
Query: 265 VKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIP-EESQLVFYGH 323
+K+W + + S ++T GH +V + +SR + + G DG V++W I E H
Sbjct: 545 IKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAH 604
Query: 324 QGSIDCIHLIN-EEHMVSGADDGSVALW 350
+ + +H ++H ++GA D V LW
Sbjct: 605 EDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 70.1 bits (170), Expect = 4e-12
Identities = 78/329 (23%), Positives = 130/329 (39%), Gaps = 74/329 (22%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+ VL H ++T L + D + S+ +D I W ++S + +P + E
Sbjct: 188 LAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP-VFESVEAAVLLP 246
Query: 199 SSHVLCMAISSDGKY-LASGDRSKLILIWEAQSCQHLYT--------------------- 236
V + + S G Y L +GD+ L +WEA S Q +YT
Sbjct: 247 EEPVSQLGVKSPGLYFLTAGDQGTL-RVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAG 305
Query: 237 ------------------------FTGHRDAVSGLAFR--RGTHQLYSTSHDRSVKVWNV 270
F G+ + V + F +H + + S+ +KV+ +
Sbjct: 306 VVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA-SNSPCLKVFEL 364
Query: 271 AENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFY----GHQGS 326
+ S + L GH D V ALD + + +D +VR+W++ + Q++ GH S
Sbjct: 365 -QTSACQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHS 423
Query: 327 ID--CIHLINEEHMVSGADDGSVALWGLSK----------KRPLALQREAHGLRGEPGLE 374
+ C + E +V+G+ D +V LW L K P+ LQ + +
Sbjct: 424 VGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKD-- 481
Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLW 403
I+SVA N L+ATGS +LW
Sbjct: 482 ----INSVAIAPNDKLLATGSQDRTAKLW 506
Score = 70.1 bits (170), Expect = 4e-12
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 13/176 (7%)
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHV 202
R H I + + P+D + + ++D + W++ + L V GH +
Sbjct: 476 RCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFS-----------GHRRGL 524
Query: 203 LCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAF-RRGTHQLYSTSH 261
C+ S + LA+ I +W Q L TF GH +V +AF RGT QL S+
Sbjct: 525 WCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGT-QLLSSGS 583
Query: 262 DRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQ 317
D VK+W + N V TL H+D V L + G D V +WK E++
Sbjct: 584 DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639
Score = 56.6 bits (135), Expect = 5e-08
Identities = 54/266 (20%), Positives = 107/266 (40%), Gaps = 30/266 (11%)
Query: 146 QLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCM 205
Q IT ++PD+ + +A++ + +W+ + G + R K H++ V M
Sbjct: 66 QEDITAFDLSPDNEVLVTASRALLLAQWAWQEGS----VTRLWKAI------HTAPVATM 115
Query: 206 AISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL--YSTSHDR 263
A LA+G + +W+ + F G V +AF +L +S++ D
Sbjct: 116 AFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDA 175
Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGH 323
+++VW++ + S + L H AV +L + + + GRD +W +
Sbjct: 176 AIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPV 235
Query: 324 QGSIDCIHLINEE------------HMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371
S++ L+ EE + ++ D G++ +W + + + Q + P
Sbjct: 236 FESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ------PP 289
Query: 372 GLEQPFWISSVAALLNTDLVATGSHS 397
G Q ++A L AT H+
Sbjct: 290 GPGQELTHCTLAHTAGVVLTATADHN 315
Score = 48.5 bits (114), Expect = 1e-05
Identities = 40/155 (25%), Positives = 62/155 (40%), Gaps = 12/155 (7%)
Query: 124 QKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHV 183
Q AK P + V GH+ + C+ +P D + +A+ D +I W+++ L
Sbjct: 499 QDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Query: 184 IPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDA 243
GH + VL +A S G L S L+ +W ++ + + T H D
Sbjct: 559 F-----------EGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDK 607
Query: 244 VSGL-AFRRGTHQLYSTSHDRSVKVWNVAENSYVE 277
V GL R H L S R + +V E E
Sbjct: 608 VWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAE 642
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 77.0 bits (188), Expect = 3e-14
Identities = 52/176 (29%), Positives = 82/176 (46%), Gaps = 15/176 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPP-- 196
I +L+G + +TCL +PD + +D SI +S+ SG EG
Sbjct: 58 ILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSG-------------EGNVTFN 104
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH + + + G LASG + I++W+ + LY GH+DA++ F R + L
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLL 164
Query: 257 YSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKI 312
++ D VK W++ +T+ GH+ V L LS E + G D +RVW I
Sbjct: 165 VTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 74.3 bits (181), Expect = 2e-13
Identities = 58/231 (25%), Positives = 103/231 (44%), Gaps = 15/231 (6%)
Query: 126 LVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCS-IIKWSVESGRKLHVI 184
L + ++ ASA V+ G Q V + + A C + W + G K+ ++
Sbjct: 3 LTKQYLRYVASAVFGVI-GSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILIL 61
Query: 185 PRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAV 244
K+ V C+ S DG +LA G I I+ S + TF GH+ A+
Sbjct: 62 QGLKQ-----------EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAI 110
Query: 245 SGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRD 304
+ L + + +L S S D + VW+V S + L GH+DA+ L + + G+D
Sbjct: 111 TTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKD 170
Query: 305 GTVRVWKIPEESQL-VFYGHQGSIDCIHLINEE-HMVSGADDGSVALWGLS 353
V+ W + + GH+ + + L++EE +++GA D + +W ++
Sbjct: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA 221
Score = 62.8 bits (151), Expect = 7e-10
Identities = 48/227 (21%), Positives = 98/227 (43%), Gaps = 3/227 (1%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
+ + H ++ + ++PD + D S+ W E + + + + +
Sbjct: 489 LETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQL 548
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
VLC++ S + K LA + I+ + + + GH+ V + + +
Sbjct: 549 DEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIAT 608
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-ESQ 317
S DR+VK+W + ++LF H D+V L + + G+D ++ W + E
Sbjct: 609 GSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI 668
Query: 318 LVFYGHQGSIDCIHLI-NEEHMVSGADDGSVALWGLSKKRPLALQRE 363
GH I C+ + + +++VS + D S+ LW +++ PL L+ E
Sbjct: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE-PLILEEE 714
Score = 52.8 bits (125), Expect = 7e-07
Identities = 79/410 (19%), Positives = 153/410 (37%), Gaps = 72/410 (17%)
Query: 44 KMNEEISSDSESESLAPRKPEEEEEE-ELEETAQEKKLRLAKLYLEQLRQQEEEKAEARA 102
KM++++ + L K EEE+ E +E + Q++ R+ + + A+ ++
Sbjct: 317 KMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNI---------KTSAKIKS 367
Query: 103 FEE-DQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLR----GHQLSITCLVVTPD 157
F+ G LK L Q L +L + P +R R GH+ + L + D
Sbjct: 368 FDLIHSPHGELKAVFLLQNN-LVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSD 426
Query: 158 DSAIFSAAKDCSIIKWSVESGRKLHV-----------IPRAKKGAEGKPPG--------- 197
+ A+ SAA D SI W+ + + + +P ++ G G
Sbjct: 427 NIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLAS 485
Query: 198 ---------HSSHVLCMAISSDGKYLASGDRSKLILIWEAQ------------SCQHLYT 236
H + M++S D + +G K + W+ + S + T
Sbjct: 486 GNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRT 545
Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296
D + +++ L + D +VK++ V + +L+GH+ V +D
Sbjct: 546 LQLDEDVLC-VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
Query: 297 CVTAGGRDGTVRVWKIP-EESQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSK 354
+ G D V++W + + + H S+ + + + H+ + D + W K
Sbjct: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
Query: 355 KRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQ 404
+ H Q W +V+ + D V + SH +RLW+
Sbjct: 665 FEHIQTLEGHH---------QEIWCLAVSP--SGDYVVSSSHDKSLRLWE 703
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/134 (22%), Positives = 53/134 (39%), Gaps = 11/134 (8%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ +IT L + S +KD II W V + L+ + GH +
Sbjct: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-----------GHKDAIT 153
Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263
+ L + + ++ W+ + T GHR V GL +L + + D
Sbjct: 154 QALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDS 213
Query: 264 SVKVWNVAENSYVE 277
++VW++A +E
Sbjct: 214 ELRVWDIAYLQEIE 227
>gi|72534670 phospholipase A2-activating protein [Homo sapiens]
Length = 795
Score = 75.9 bits (185), Expect = 8e-14
Identities = 74/273 (27%), Positives = 118/273 (43%), Gaps = 31/273 (11%)
Query: 142 LRGHQLSITCLVVTP-DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200
LRGH+L + LV A S ++D + W+ +S + G HS+
Sbjct: 14 LRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHCMSG-------HSN 66
Query: 201 HVLCMAI--SSD---GKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRR-GTH 254
V C+ I SSD +A+G I I+ S LY GH++ V L+ + GT
Sbjct: 67 FVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGT- 125
Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314
L S S D + KVW + + TL GH AV A+ L + + G D TV++WK
Sbjct: 126 -LLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK-AG 181
Query: 315 ESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLE 374
+ F GH+ + + +++E +S A+D S+ W ++ G E
Sbjct: 182 RCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQIT------------GECLEVYYG 229
Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGE 407
+I S++ N T + +R+W+ GE
Sbjct: 230 HTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGE 262
Score = 69.7 bits (169), Expect = 5e-12
Identities = 60/270 (22%), Positives = 115/270 (42%), Gaps = 38/270 (14%)
Query: 120 RGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDD-----SAIFSAAKDCSIIKWS 174
R R +L A + + ++ + GH ++C+ + P I + D +I +S
Sbjct: 39 RDRTTRLWAPDSPNRSFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFS 98
Query: 175 VESGRKLHVIPRAKKG----AEGK------------------------PPGHSSHVLCMA 206
++S L+++ K + GK GH++ V +
Sbjct: 99 LDSPMPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVK 158
Query: 207 ISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVK 266
I + + +G K + +W+A C+ TF+GH D V GLA T + S ++D S++
Sbjct: 159 ILPEQGLMLTGSADKTVKLWKAGRCER--TFSGHEDCVRGLAILSET-EFLSCANDASIR 215
Query: 267 VWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGS 326
W + +E +GH + + ++ D ++R+WK E +Q + Q S
Sbjct: 216 RWQIT-GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQ-S 273
Query: 327 IDCIHLINEEHMVSGADDGSVALWGLSKKR 356
I C +++ +V GA DG + ++ S+ R
Sbjct: 274 IWCCCVLDNGDIVVGASDGIIRVFTESEDR 303
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 75.1 bits (183), Expect = 1e-13
Identities = 80/361 (22%), Positives = 136/361 (37%), Gaps = 69/361 (19%)
Query: 87 LEQLRQQEEEK----AEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVL 142
+EQLRQ+ E+ A+AR D L LE GR+Q R L
Sbjct: 4 MEQLRQEAEQLKKQIADARKACADVTLAELVSG-LEVVGRVQMRTR-----------RTL 51
Query: 143 RGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAK-------------- 188
RGH I + D + SA++D +I W + K+H IP
Sbjct: 52 RGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNF 111
Query: 189 ---------------KGAEG------KPPGHSSHVLCMAISSDGKYL-ASGDRSKLILIW 226
K EG + H+ ++ C D + +SGD + +W
Sbjct: 112 VACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT--CALW 169
Query: 227 EAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAV 286
+ ++ Q F GH LA + S + D S K+W+V E + +T GH+ +
Sbjct: 170 DIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDI 229
Query: 287 AALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQ----GSIDCIHLINEEHMVSGA 342
A+ + G D + R++ + + +L+ + H+ G ++ + +G
Sbjct: 230 NAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGY 289
Query: 343 DDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRL 402
DD + +W K + + H R +S + + VATGS S +++
Sbjct: 290 DDFNCNVWDSMKSERVGI-LSGHDNR----------VSCLGVTADGMAVATGSWDSFLKI 338
Query: 403 W 403
W
Sbjct: 339 W 339
Score = 35.0 bits (79), Expect = 0.15
Identities = 28/130 (21%), Positives = 54/130 (41%), Gaps = 17/130 (13%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ I + P+ AI + + D S + + + ++L H S ++
Sbjct: 224 GHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICF------------SHES-II 270
Query: 204 C----MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST 259
C +A S G+ L +G +W++ + + +GH + VS L + +
Sbjct: 271 CGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATG 330
Query: 260 SHDRSVKVWN 269
S D +K+WN
Sbjct: 331 SWDSFLKIWN 340
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 74.7 bits (182), Expect = 2e-13
Identities = 52/203 (25%), Positives = 93/203 (45%), Gaps = 13/203 (6%)
Query: 135 ASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 194
A+ +R L GH+ +I L P + S ++D +I W + +KG +
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR-----------RKGCVFR 142
Query: 195 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTH 254
GHS V C+ S DGK+LAS + +W+ + + + F GH V+ + F +
Sbjct: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDG-TVRVWKIP 313
L S S DR+++ W++ + V + G V ++ CC+ +G +D V W+ P
Sbjct: 203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE-P 261
Query: 314 EESQLVFYGHQGSIDCIHLINEE 336
E V + G + + + N++
Sbjct: 262 ERCFDVVLVNWGKVADLAICNDQ 284
Score = 73.9 bits (180), Expect = 3e-13
Identities = 52/231 (22%), Positives = 101/231 (43%), Gaps = 20/231 (8%)
Query: 145 HQLSITCLVVTPDDSAIFSAA-KDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
H +++ LV+ + + DC + WS+ + + GH+S V
Sbjct: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT-----------GHTSPVE 67
Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263
+ +++ + + +G +S I +W+ ++ + L T GH+ + L F + S S D
Sbjct: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-VFYG 322
++K+W++ V GH AV L + + D TV++W + + F G
Sbjct: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPG 372
H G ++ + NE + SG+ D ++ W L K + ++ + GEPG
Sbjct: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC------IEGEPG 232
Score = 67.8 bits (164), Expect = 2e-11
Identities = 52/222 (23%), Positives = 99/222 (44%), Gaps = 18/222 (8%)
Query: 139 IRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGH 198
I L GH + + + + I + ++ SI W +E+ + L + GH
Sbjct: 56 IMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL-----------MGH 104
Query: 199 SSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYS 258
+++ + G+++ASG + I +W+ + ++ + GH AV L F L S
Sbjct: 105 KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLAS 164
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
+ D +VK+W++ + GH V ++ E + +G D T+R W + E+ Q+
Sbjct: 165 AADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL-EKFQV 223
Query: 319 V--FYGHQGSIDCIHLINEEH--MVSGADDGSVALWGLSKKR 356
V G G + + L N + + SG D S+ ++G +R
Sbjct: 224 VSCIEGEPGPVRSV-LFNPDGCCLYSGCQD-SLRVYGWEPER 263
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 74.7 bits (182), Expect = 2e-13
Identities = 70/322 (21%), Positives = 134/322 (41%), Gaps = 40/322 (12%)
Query: 138 DIRVLRGHQLSITCLVVTP---DDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGK 194
++ L GH+ + + D A S K C + WSVE+G+ H
Sbjct: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL--WSVETGKCYHTFR--------- 174
Query: 195 PPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTH 254
GH++ ++C++ + +A+G +W+ Q+ + +YT GH + L+F
Sbjct: 175 --GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGD 232
Query: 255 QLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC-CVTAGGRDGTVRVWKIP 313
++ + S D +V VW+ V L GH +++ + + +C + G D T ++W
Sbjct: 233 RIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA-SFNWDCSLILTGSMDKTCKLWDAT 291
Query: 314 E-ESQLVFYGHQGSI-DCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEP 371
+ GH I D + + + + DG+ ++ + ++ +A + G GE
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIA---KLEGHEGE- 347
Query: 372 GLEQPFWISSVAALLNTDLVATGSHSSCVRLW--QCGEGFRQLDLLCDIPLVGFINSLKF 429
IS ++ + + TGS R+W Q G+ + L+ D I S F
Sbjct: 348 -------ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD-----EIFSCAF 395
Query: 430 SSSGDFLVAGVGQEHRLGRWWR 451
+ G+ ++ G + R WR
Sbjct: 396 NYKGNIVI--TGSKDNTCRIWR 415
Score = 67.4 bits (163), Expect = 3e-11
Identities = 48/207 (23%), Positives = 83/207 (40%), Gaps = 14/207 (6%)
Query: 205 MAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYST-SHDR 263
+A++ G +G + +W+ S + L T GHR+ V +AF +T S D+
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDK 157
Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE-ESQLVFYG 322
+ K+W+V T GH + L + V G D T ++W I E G
Sbjct: 158 TCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG 217
Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381
H I + + + +++G+ D +V +W R + + + ISS
Sbjct: 218 HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL-----------IGHCAEISS 266
Query: 382 VAALLNTDLVATGSHSSCVRLWQCGEG 408
+ + L+ TGS +LW G
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNG 293
Score = 59.7 bits (143), Expect = 6e-09
Identities = 37/179 (20%), Positives = 72/179 (40%), Gaps = 11/179 (6%)
Query: 133 APASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAE 192
A + +L GH I+ D S I + + D + W +G+ + +
Sbjct: 248 ADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL-------- 299
Query: 193 GKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRG 252
GH +L GK +A+ I+ A + + + GH +S ++F
Sbjct: 300 ---TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
Query: 253 THQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWK 311
+ L + S D++ ++W+ ++ L GH D + + + V G +D T R+W+
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/225 (23%), Positives = 98/225 (43%), Gaps = 24/225 (10%)
Query: 244 VSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC--CVTAG 301
++ +A + + S+DR+ K+W+ A + TL GH++ V A+ A + + G
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI-AFNNPYGDKIATG 153
Query: 302 GRDGTVRVWKIPE-ESQLVFYGHQGSIDCIHLINEEHMV-SGADDGSVALWGLSKKRPLA 359
D T ++W + + F GH I C+ + +V +G+ D + LW +
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN----- 208
Query: 360 LQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIP 419
E + LRG I S++ + D + TGS V +W G R++++L I
Sbjct: 209 -GEEVYTLRGHSA-----EIISLSFNTSGDRIITGSFDHTVVVWDADTG-RKVNIL--IG 259
Query: 420 LVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPL 464
I+S F+ ++ G + + ++ +A N C+ L
Sbjct: 260 HCAEISSASFNWDCSLILTG-----SMDKTCKLWDATNGKCVATL 299
Score = 32.7 bits (73), Expect = 0.74
Identities = 20/99 (20%), Positives = 39/99 (39%), Gaps = 11/99 (11%)
Query: 128 AKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRA 187
A+ A I L GH+ I+ + P + + + + D + W ++G+ L V+
Sbjct: 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVL--- 383
Query: 188 KKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIW 226
GH+ + A + G + +G + IW
Sbjct: 384 --------EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 74.3 bits (181), Expect = 2e-13
Identities = 65/287 (22%), Positives = 122/287 (42%), Gaps = 57/287 (19%)
Query: 154 VTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKY 213
+T D S + +A+ D ++ W +E+G+ L + + + ++ S DGKY
Sbjct: 153 ITGDSSRVIAASYDKTVRAWDLETGKLLWKVR------------YDTFIVSCKFSPDGKY 200
Query: 214 LASG-DRSKLILIWEAQSCQHLYTFTGHRD-AVSGLAFRRGTHQLYSTSHDRSVKVWNVA 271
+ SG D I I +A++ + H +++ F + ++ S S DR +K+W+V
Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
Query: 272 ENSYVETLF-GHQDAVAALDALSRECCVTAGGR-------DGTVRVWKIPEES------- 316
+ + T+ H +A++ CC T G D +++W +
Sbjct: 261 SQATLLTITKAHSNAIS-------NCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGAC 313
Query: 317 QLVFYGHQGSIDCIHLINEEH-MVSGADDGSVALWGLSKK-RPLALQREAHGLRGEPGLE 374
+ GH+GS+ H + ++SG D +VA+W +++ R L+L+
Sbjct: 314 VTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHND--------- 364
Query: 375 QPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLV 421
W+ VA N + + S +RLW E + +IPLV
Sbjct: 365 ---WVMDVAISNNKKWILSASKDRTMRLWNIEE-------IDEIPLV 401
Score = 68.9 bits (167), Expect = 9e-12
Identities = 51/180 (28%), Positives = 78/180 (43%), Gaps = 16/180 (8%)
Query: 145 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 204
H SIT PD + S + D I W V S L I +A HS+ +
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKA----------HSNAISN 278
Query: 205 MAISSDGKYLASGDRSKLILIW-----EAQSCQHLYTFT-GHRDAVSGLAFRRGTHQLYS 258
+ G +L + K + IW E ++C T GH +VS F R + L S
Sbjct: 279 CCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLIS 338
Query: 259 TSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL 318
DR+V +W+VAE +L GH D V + + + + + +D T+R+W I E ++
Sbjct: 339 GGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEI 398
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 73.9 bits (180), Expect = 3e-13
Identities = 66/246 (26%), Positives = 102/246 (41%), Gaps = 22/246 (8%)
Query: 197 GHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQL 256
GH V C+ S + K LASG +++W + Y FTGH+DAV+ + F H L
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 257 YSTSHDRSVKVW--NVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPE 314
S S D++V++W NV S V H V ++ S D TV+VW
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 315 ESQLVFYG-HQGSIDCIHLINEEHM-VSGADDGSVALWGLSKKRPLALQREAHGLRGEPG 372
+ L H + C + + VS +DD +V LW S + + E G
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG------ 188
Query: 373 LEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPL-VGFINSLKFSS 431
+++ V + +A + V++W R LL L +N L F
Sbjct: 189 -----FVTYVDFHPSGTCIAAAGMDNTVKVWD----VRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 432 SGDFLV 437
SG++L+
Sbjct: 240 SGNYLI 245
Score = 72.8 bits (177), Expect = 6e-13
Identities = 56/222 (25%), Positives = 99/222 (44%), Gaps = 31/222 (13%)
Query: 237 FTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSREC 296
F GHRDAV+ + F T QL S S D + VW++ S GH+DAV ++
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 297 CVTAGGRDGTVRVWKIP--EESQLVFYGHQGSIDCIHLINE-EHMVSGADDGSVALWGLS 353
+ +G RD TVR+W +P + VF H ++ +H ++ + V+ +DD +V +W
Sbjct: 75 LLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 354 KKRPL-ALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLW-----QCGE 407
+++ L +L + + W+ + L+ + S V+LW +C
Sbjct: 134 RQKFLFSLSQHIN------------WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH 181
Query: 408 GFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRW 449
+ + GF+ + F SG +A G ++ + W
Sbjct: 182 SYCEHG--------GFVTYVDFHPSGT-CIAAAGMDNTVKVW 214
Score = 70.9 bits (172), Expect = 2e-12
Identities = 56/263 (21%), Positives = 111/263 (42%), Gaps = 24/263 (9%)
Query: 144 GHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVL 203
GH+ ++TC+ +P + S ++D ++ W +P KG H++ V
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSRDKTVRIW----------VPNV-KGESTVFRAHTATVR 107
Query: 204 CMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDR 263
+ SDG+ + K + +W + L++ + H + V F + S S D+
Sbjct: 108 SVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDK 167
Query: 264 SVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYG- 322
+VK+W+ + V + H V +D C+ A G D TV+VW + L Y
Sbjct: 168 TVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL 227
Query: 323 HQGSIDCIHL-INEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISS 381
H +++ + + ++++ + D ++ + L + R L HG +G ++
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGR---LLYTLHGHQGP--------ATT 276
Query: 382 VAALLNTDLVATGSHSSCVRLWQ 404
VA + A+G V +W+
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWK 299
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/212 (21%), Positives = 86/212 (40%), Gaps = 13/212 (6%)
Query: 141 VLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSS 200
V R H ++ + D + +A+ D ++ W+ + L + + H +
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQ-----------HIN 146
Query: 201 HVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTS 260
V C S DG+ + S K + +W+ S + ++++ H V+ + F + +
Sbjct: 147 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 261 HDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQL-V 319
D +VKVW+V + ++ H AV L + D T+++ + E L
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 320 FYGHQGSIDCIHLINE-EHMVSGADDGSVALW 350
+GHQG + E+ SG D V +W
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 33.5 bits (75), Expect = 0.43
Identities = 18/84 (21%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 145 HQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLC 204
H ++ L P + + +A+ D ++ + GR L+ + GH
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLH-----------GHQGPATT 276
Query: 205 MAISSDGKYLASGDRSKLILIWEA 228
+A S G+Y ASG + +++W++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,690,572
Number of Sequences: 37866
Number of extensions: 970917
Number of successful extensions: 18309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 414
Number of HSP's successfully gapped in prelim test: 587
Number of HSP's that attempted gapping in prelim test: 10157
Number of HSP's gapped (non-prelim): 5302
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.