Search of human proteins with 47271475

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47271475 SPOC domain containing 1 [Homo sapiens]
         (1216 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47271475 SPOC domain containing 1 [Homo sapiens]                  2502   0.0  
gi|7662018 PHD finger protein 3 [Homo sapiens]                        193   1e-48
gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]      107   7e-23
gi|71044477 death inducer-obliterator 1 isoform b [Homo sapiens]      107   7e-23
gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo ...    51   8e-06
gi|5803191 transcription elongation factor A 1 isoform 1 [Homo s...    51   8e-06
gi|45439355 transcription elongation factor A 1 isoform 2 [Homo ...    51   8e-06
gi|38505156 transcription elongation factor A protein 2 isoform ...    49   4e-05
gi|4507385 transcription elongation factor A protein 2 isoform a...    49   4e-05
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      47   8e-05
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              47   8e-05
gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]             47   1e-04
gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]    47   1e-04
gi|29725624 collagen, type XXIII, alpha 1 [Homo sapiens]               46   2e-04
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      46   2e-04
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    46   2e-04
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    46   2e-04
gi|55750053 atrophin-1 [Homo sapiens]                                  46   2e-04
gi|55750041 atrophin-1 [Homo sapiens]                                  46   2e-04
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]                       46   2e-04
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]                       46   2e-04
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]                       46   2e-04
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]                       46   2e-04
gi|163965366 nascent polypeptide-associated complex alpha subuni...    45   5e-04
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]        44   0.001
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        44   0.001
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    44   0.001
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    44   0.001
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    44   0.001
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    44   0.001

>gi|47271475 SPOC domain containing 1 [Homo sapiens]
          Length = 1216

 Score = 2502 bits (6484), Expect = 0.0
 Identities = 1216/1216 (100%), Positives = 1216/1216 (100%)

Query: 1    MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIP 60
            MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIP
Sbjct: 1    MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIP 60

Query: 61   RKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQ 120
            RKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQ
Sbjct: 61   RKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQ 120

Query: 121  VSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRR 180
            VSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRR
Sbjct: 121  VSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRR 180

Query: 181  SPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSV 240
            SPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSV
Sbjct: 181  SPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSV 240

Query: 241  GDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP 300
            GDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP
Sbjct: 241  GDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP 300

Query: 301  CGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD 360
            CGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD
Sbjct: 301  CGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD 360

Query: 361  QEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSK 420
            QEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSK
Sbjct: 361  QEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSK 420

Query: 421  GTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP 480
            GTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP
Sbjct: 421  GTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP 480

Query: 481  VIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSP 540
            VIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSP
Sbjct: 481  VIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSP 540

Query: 541  SGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQE 600
            SGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQE
Sbjct: 541  SGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQE 600

Query: 601  KPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYK 660
            KPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYK
Sbjct: 601  KPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYK 660

Query: 661  TKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNII 720
            TKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNII
Sbjct: 661  TKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNII 720

Query: 721  EQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQ 780
            EQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQ
Sbjct: 721  EQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQ 780

Query: 781  HDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPT 840
            HDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPT
Sbjct: 781  HDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPT 840

Query: 841  EPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTV 900
            EPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTV
Sbjct: 841  EPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTV 900

Query: 901  IRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLAS 960
            IRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLAS
Sbjct: 901  IRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLAS 960

Query: 961  VEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGL 1020
            VEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGL
Sbjct: 961  VEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGL 1020

Query: 1021 PDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAP 1080
            PDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAP
Sbjct: 1021 PDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAP 1080

Query: 1081 RGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFH 1140
            RGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFH
Sbjct: 1081 RGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFH 1140

Query: 1141 RDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSL 1200
            RDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSL
Sbjct: 1141 RDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSL 1200

Query: 1201 GPTDEAGSECPFPRKA 1216
            GPTDEAGSECPFPRKA
Sbjct: 1201 GPTDEAGSECPFPRKA 1216


>gi|7662018 PHD finger protein 3 [Homo sapiens]
          Length = 2039

 Score =  193 bits (490), Expect = 1e-48
 Identities = 152/473 (32%), Positives = 225/473 (47%), Gaps = 74/473 (15%)

Query: 566  GDPSSDPACSQSGPME---AEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWT 622
            G+ +S P   +   M+    E+  L   P  SA     KPS    +R +V  S++++L  
Sbjct: 887  GEKASKPGTHEKQEMKKKKVEKGVLNVHPAASAS----KPSAD-QIRQSVRHSLKDILMK 941

Query: 623  RLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKV 682
            RL +  +  + EE    +A  IE  L+   + T+ +YK KYRSL+FNL+DP+N  LF KV
Sbjct: 942  RLTD-SNLKVPEEKAAKVATKIEKELFSFFRDTDAKYKNKYRSLMFNLKDPKNNILFKKV 1000

Query: 683  VHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVE 742
            + G+VTP  L+RMS  +LA +ELA WR +E +  + +IE++Q+E  R P +K+THKGE+E
Sbjct: 1001 LKGEVTPDHLIRMSPEELASKELAAWRRRENRHTIEMIEKEQREVERRPITKITHKGEIE 1060

Query: 743  IQRD---MDQTLTLE--------DLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCH 791
            I+ D    +Q   +E         L  P+   +   + +   S+DTT QH  H  D NC 
Sbjct: 1061 IESDAPMKEQEAAMEIQEPAANKSLEKPE-GSEKQKEEVDSMSKDTTSQHRQHLFDLNCK 1119

Query: 792  IC--------KDWEP-------------SNELLGSFEAAKSCGDNIFQKALSQ------- 823
            IC         D  P             S+    S   A S   NI      +       
Sbjct: 1120 ICIGRMAPPVDDLSPKKVKVVVGVARKHSDNEAESIADALSSTSNILASEFFEEEKQESP 1179

Query: 824  ----TPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRF 879
                +P P PEMP T E+  T               A    +     W+G ++M S+ +F
Sbjct: 1180 KSTFSPAPRPEMPGTVEVESTF-------------LARLNFI-----WKGFINMPSVAKF 1221

Query: 880  RARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARD 939
              +A  VSG    L + LP  I+  G I    VWD +  I  +  K++CVVR  P    D
Sbjct: 1222 VTKAYPVSGSPEYLTEDLPDSIQVGGRISPQTVWDYVEKIKASGTKEICVVRFTPVTEED 1281

Query: 940  TQNCRLLYSYLNDRQRHGLAS---VEHMGMVLLPLPAFQPLPTRLRPLGGPGL 989
              +  LL++Y + R+R+G+A+    +   M L+PL A   +P  L P  GPGL
Sbjct: 1282 QISYTLLFAYFSSRKRYGVAANNMKQVKDMYLIPLGATDKIPHPLVPFDGPGL 1334


>gi|71044479 death inducer-obliterator 1 isoform c [Homo sapiens]
          Length = 2240

 Score =  107 bits (267), Expect = 7e-23
 Identities = 98/361 (27%), Positives = 157/361 (43%), Gaps = 60/361 (16%)

Query: 523 KRPMVQ-----GPAGCQVFQPSPSGGTAGDP---------GGLSDPFYPPRSGSLALGDP 568
           KRP +      G +  +   P+P+  TA            G +  P  P          P
Sbjct: 596 KRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVP--------SVP 647

Query: 569 SSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELP 628
            + PA  + G M A     P QP                +R  + RS++E+LW R+ +  
Sbjct: 648 MASPAPGRLGAMSAA----PSQPNSQ-------------IRQNIRRSLKEILWKRVNDSD 690

Query: 629 DPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVT 688
           D +++E  V  IA  IE  +++L Q T+ RYK+KYRS++FNL+DP+N  LF +V+  +++
Sbjct: 691 DLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEIS 750

Query: 689 PYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDMD 748
              LVR+   +L  +EL+ W+   E+   +++E + K       SK T   +  I  D++
Sbjct: 751 LAKLVRLKPEELVSKELSTWK---ERPARSVMESRTK---LHNESKKTAPRQEAIP-DLE 803

Query: 749 QTLTLEDLVGPQMFMDCSPQ--ALPIAS------EDTTGQHDHHFLDPNCHICKDWEPSN 800
            +  + D    Q      P+    P+        +DTT QH  H  D NC IC    PS 
Sbjct: 804 DSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSA 863

Query: 801 ELLGSFEAAKSCG----DNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAA 856
           E   + +  K       +++  K  S  P PAP+     E+ P    +     GL   + 
Sbjct: 864 EDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPD--SADEVMPEAVPEVASEPGLESASH 921

Query: 857 P 857
           P
Sbjct: 922 P 922



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 54/180 (30%), Positives = 87/180 (48%), Gaps = 16/180 (8%)

Query: 819  KALSQTPMPAPE-----MPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPP-WEGVLD 872
            K++   P  +P+     +P +  +S +E   R PP G       T  L  L   W+G ++
Sbjct: 1010 KSILAKPSSSPDPRYLSVPPSPNISTSE--SRSPPEG-----DTTLFLSRLSTIWKGFIN 1062

Query: 873  MFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRL 932
            M S+ +F  +A  VSG    L + LP  I   G I    VWD +  +  + +K++C++R 
Sbjct: 1063 MQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRF 1122

Query: 933  CPHGARDTQNCRLLYSYLNDRQRHGLASVEH---MGMVLLPLPAFQPLPTRLRPLGGPGL 989
             P    +      LYSY + R R G+ +  +     + L+PL A  P+P++L P  GPGL
Sbjct: 1123 HPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPGL 1182



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 95/413 (23%), Positives = 142/413 (34%), Gaps = 91/413 (22%)

Query: 189  PPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVAD 248
            PP    ++  DP      ++ RR  A  E  EG G+ L    +      L    P + A 
Sbjct: 1549 PPASQASNHRDP------RQARRLAA--ETGEGEGEPLSRLSARGAQGAL----PERDAS 1596

Query: 249  LESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGS--------- 299
               L G    P P++       P  SG    +G+E+ G+    G+G +P +         
Sbjct: 1597 RGGLVGQAPMPVPEEKEPA-SSPWASGEKPPAGSEQDGWKAEPGEGTRPATVGDSSARPA 1655

Query: 300  --------PCGPV--GFPVPSGGE--------------SLSSAAQAPPQSAALCLGASAQ 335
                    PCG +  GFP+   GE              +L SA    P++      +S+ 
Sbjct: 1656 RRVLLPTPPCGALQPGFPLQHDGERDPFTCPGFASQDKALGSAQYEDPRNLHSAGRSSSP 1715

Query: 336  ASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLG 395
            A   + +     R G  EG AP     +    +QP  +G+ E G  A           + 
Sbjct: 1716 AGETEGDREPQARPG--EGTAPLPPPGQKVGGSQPPFQGQREPGPHALG---------MS 1764

Query: 396  GLSSSLDTEASRACSGPFMEQRRSKGTK---------NLKKGPVPC-------AQDRGTD 439
            GL    +    R  + PF E+  +               +KGP+P            G  
Sbjct: 1765 GLHGP-NFPGPRGPAPPFPEENIASNDGPRGPPPARFGAQKGPIPSLFSGQHGPPPYGDS 1823

Query: 440  RSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPP 499
            R    S+   P   +P    + EE K PHG K        P  ++ GA +  +   Q P 
Sbjct: 1824 RGPSPSYLGGPRGVAPS---QFEERKDPHGEKR--EFQDAPYNEVTGAPAQFEGTEQAP- 1877

Query: 500  KLEVLEDLMEVSSPSPAQ--RLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGG 550
                    +     +P Q    RR     ++GP G     PS  GG  G P G
Sbjct: 1878 -------FLGSRGGAPFQFGGQRRPLLSQLKGPRGGP--PPSQFGGQRGPPPG 1921


>gi|71044477 death inducer-obliterator 1 isoform b [Homo sapiens]
          Length = 1189

 Score =  107 bits (267), Expect = 7e-23
 Identities = 98/361 (27%), Positives = 157/361 (43%), Gaps = 60/361 (16%)

Query: 523 KRPMVQ-----GPAGCQVFQPSPSGGTAGDP---------GGLSDPFYPPRSGSLALGDP 568
           KRP +      G +  +   P+P+  TA            G +  P  P          P
Sbjct: 596 KRPWLSATPSSGASAARQAGPAPAAATAASKKFPGSAALVGAVRKPVVP--------SVP 647

Query: 569 SSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELP 628
            + PA  + G M A     P QP                +R  + RS++E+LW R+ +  
Sbjct: 648 MASPAPGRLGAMSAA----PSQPNSQ-------------IRQNIRRSLKEILWKRVNDSD 690

Query: 629 DPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVT 688
           D +++E  V  IA  IE  +++L Q T+ RYK+KYRS++FNL+DP+N  LF +V+  +++
Sbjct: 691 DLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEIS 750

Query: 689 PYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDMD 748
              LVR+   +L  +EL+ W+   E+   +++E + K       SK T   +  I  D++
Sbjct: 751 LAKLVRLKPEELVSKELSTWK---ERPARSVMESRTK---LHNESKKTAPRQEAIP-DLE 803

Query: 749 QTLTLEDLVGPQMFMDCSPQ--ALPIAS------EDTTGQHDHHFLDPNCHICKDWEPSN 800
            +  + D    Q      P+    P+        +DTT QH  H  D NC IC    PS 
Sbjct: 804 DSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSA 863

Query: 801 ELLGSFEAAKSCG----DNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAA 856
           E   + +  K       +++  K  S  P PAP+     E+ P    +     GL   + 
Sbjct: 864 EDEPAPKKQKLSASVKKEDLKSKHDSSAPDPAPD--SADEVMPEAVPEVASEPGLESASH 921

Query: 857 P 857
           P
Sbjct: 922 P 922



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 16/179 (8%)

Query: 819  KALSQTPMPAPE-----MPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPP-WEGVLD 872
            K++   P  +P+     +P +  +S +E   R PP G       T  L  L   W+G ++
Sbjct: 1010 KSILAKPSSSPDPRYLSVPPSPNISTSE--SRSPPEG-----DTTLFLSRLSTIWKGFIN 1062

Query: 873  MFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRL 932
            M S+ +F  +A  VSG    L + LP  I   G I    VWD +  +  + +K++C++R 
Sbjct: 1063 MQSVAKFVTKAYPVSGCFDYLSEDLPDTIHIGGRIAPKTVWDYVGKLKSSVSKELCLIRF 1122

Query: 933  CPHGARDTQNCRLLYSYLNDRQRHGLASVEH---MGMVLLPLPAFQPLPTRLRPLGGPG 988
             P    +      LYSY + R R G+ +  +     + L+PL A  P+P++L P  GPG
Sbjct: 1123 HPATEEEEVAYISLYSYFSSRGRFGVVANNNRHVKDLYLIPLSAQDPVPSKLLPFEGPG 1181


>gi|239749424 PREDICTED: hypothetical protein XP_002347041 [Homo
           sapiens]
          Length = 287

 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 38/160 (23%), Positives = 70/160 (43%), Gaps = 7/160 (4%)

Query: 565 LGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIG-------VRGTVVRSMQ 617
           L +   +PA +     EA E+S       + + +      Y+           +V    +
Sbjct: 72  LDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYVSSFPRAPSTSDSVRLKCR 131

Query: 618 EVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLD 677
           E+L   LR   D +      E + + IE A++   + T+ +YK + RS + NL+D +N +
Sbjct: 132 EMLAAALRTGDDYIAIGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPN 191

Query: 678 LFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGL 717
           L   V+ G++ P    RM++ ++A  EL   R    K  +
Sbjct: 192 LRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAI 231


>gi|5803191 transcription elongation factor A 1 isoform 1 [Homo
           sapiens]
          Length = 301

 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 38/160 (23%), Positives = 70/160 (43%), Gaps = 7/160 (4%)

Query: 565 LGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIG-------VRGTVVRSMQ 617
           L +   +PA +     EA E+S       + + +      Y+           +V    +
Sbjct: 86  LDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYVSSFPRAPSTSDSVRLKCR 145

Query: 618 EVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLD 677
           E+L   LR   D +      E + + IE A++   + T+ +YK + RS + NL+D +N +
Sbjct: 146 EMLAAALRTGDDYIAIGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPN 205

Query: 678 LFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGL 717
           L   V+ G++ P    RM++ ++A  EL   R    K  +
Sbjct: 206 LRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAI 245


>gi|45439355 transcription elongation factor A 1 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 38/160 (23%), Positives = 70/160 (43%), Gaps = 7/160 (4%)

Query: 565 LGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIG-------VRGTVVRSMQ 617
           L +   +PA +     EA E+S       + + +      Y+           +V    +
Sbjct: 65  LDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYVSSFPRAPSTSDSVRLKCR 124

Query: 618 EVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLD 677
           E+L   LR   D +      E + + IE A++   + T+ +YK + RS + NL+D +N +
Sbjct: 125 EMLAAALRTGDDYIAIGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPN 184

Query: 678 LFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGL 717
           L   V+ G++ P    RM++ ++A  EL   R    K  +
Sbjct: 185 LRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAI 224


>gi|38505156 transcription elongation factor A protein 2 isoform b
           [Homo sapiens]
          Length = 272

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 41/151 (27%), Positives = 70/151 (46%), Gaps = 5/151 (3%)

Query: 568 PSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSM-QEVLWTRLRE 626
           P+S    S++     +   LP  P  + ++    P   + V    VR+  +E+L   L+ 
Sbjct: 70  PTSSRDASEAPDPSRKRPELPRAPS-TPRITTFPP---VPVTCDAVRNKCREMLTAALQT 125

Query: 627 LPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGD 686
             D V      E ++A IE  ++     T+ +YK + RS + NL+D +N DL   V+ G 
Sbjct: 126 DHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGA 185

Query: 687 VTPYDLVRMSSMQLAPQELARWRDQEEKRGL 717
           +TP  +  M+S ++A  EL   R    K  +
Sbjct: 186 ITPQQIAVMTSEEMASDELKEIRKAMTKEAI 216


>gi|4507385 transcription elongation factor A protein 2 isoform a
           [Homo sapiens]
          Length = 299

 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 41/151 (27%), Positives = 70/151 (46%), Gaps = 5/151 (3%)

Query: 568 PSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSM-QEVLWTRLRE 626
           P+S    S++     +   LP  P  + ++    P   + V    VR+  +E+L   L+ 
Sbjct: 97  PTSSRDASEAPDPSRKRPELPRAPS-TPRITTFPP---VPVTCDAVRNKCREMLTAALQT 152

Query: 627 LPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGD 686
             D V      E ++A IE  ++     T+ +YK + RS + NL+D +N DL   V+ G 
Sbjct: 153 DHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGA 212

Query: 687 VTPYDLVRMSSMQLAPQELARWRDQEEKRGL 717
           +TP  +  M+S ++A  EL   R    K  +
Sbjct: 213 ITPQQIAVMTSEEMASDELKEIRKAMTKEAI 243


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 91/381 (23%), Positives = 119/381 (31%), Gaps = 57/381 (14%)

Query: 238 LSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPA----TGD 293
           +SV  P   +    L GP   P P+     PGEPG  GA    G       P      G+
Sbjct: 175 ISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGE 234

Query: 294 GPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGS-D 352
             +PG P G  G P P G   L   A  P             A  +   A      GS  
Sbjct: 235 AGKPGRP-GERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPG 293

Query: 353 EGQAPAQDQEELEAKAQPASRGRLEQGLAAPA-----DTCASSREPLG--------GLSS 399
           E  AP Q    +  +  P  RGR   G   PA     D    +  P G        G   
Sbjct: 294 ENGAPGQ----MGPRGLPGERGR--PGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPG 347

Query: 400 SLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCP 459
           ++  +      GP    R S+G + ++  P P         + +     +P      G P
Sbjct: 348 AVGAKGEAGPQGP----RGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAP 403

Query: 460 RLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRL 519
            +       G +              G       GG   PK     +  E  +P      
Sbjct: 404 GIAGAPGFPGAR--------------GPSGPQGPGGPPGPK----GNSGEPGAPGSKGDT 445

Query: 520 RRKKRPMVQGPAGCQVFQPSPSG-----GTAGDPGGLSDPFYP-PRSGSLALGDPSSDPA 573
             K  P   GP G Q   P P+G     G  G+PG    P  P  R G  + G P +D  
Sbjct: 446 GAKGEP---GPVGVQ-GPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGV 501

Query: 574 CSQSGPMEAEEDSLPEQPEDS 594
               GP        P  P+ S
Sbjct: 502 AGPKGPAGERGSPGPAGPKGS 522



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 18/104 (17%)

Query: 232 PRGDNLLSVGDP-PQVAD-------LESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTE 283
           P+GD     GD  P+ AD       +  L GP  PP P      PG+ G SG    +G  
Sbjct: 741 PKGDR----GDAGPKGADGSPGKDGVRGLTGPIGPPGP---AGAPGDKGESGPSGPAGPT 793

Query: 284 KFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAA 327
             G   A GD  +PG P GP GF  P G +    A   P  + A
Sbjct: 794 --GARGAPGDRGEPGPP-GPAGFAGPPGADGQPGAKGEPGDAGA 834



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 79/325 (24%), Positives = 90/325 (27%), Gaps = 34/325 (10%)

Query: 254 GPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGE 313
           GP  P         PG  G  GA  A+G       P       P  P GP G P P G  
Sbjct: 374 GPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNS 433

Query: 314 SLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASR 373
               A  +   + A               A    + G+     P         +  P SR
Sbjct: 434 GEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSR 493

Query: 374 G-RLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPC 432
           G     G+A P         P          EA R        +    G K L   P   
Sbjct: 494 GFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRP------GEAGLPGAKGLTGSPGSP 547

Query: 433 AQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVC----YLGSGPVIQLLGAI 488
             D  T          RP  P P G      V    G K         G   V    GA+
Sbjct: 548 GPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAV 607

Query: 489 ----SHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGT 544
                 G+AG Q P              P PA     +     QGPAG   FQ  P  G 
Sbjct: 608 GPAGKDGEAGAQGP--------------PGPAGPAGERGE---QGPAGSPGFQGLP--GP 648

Query: 545 AGDPGGLSDPFYPPRSGSLALGDPS 569
           AG PG    P      G L    PS
Sbjct: 649 AGPPGEAGKPGEQGVPGDLGAPGPS 673



 Score = 39.3 bits (90), Expect = 0.023
 Identities = 94/384 (24%), Positives = 124/384 (32%), Gaps = 65/384 (16%)

Query: 240 VGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTE-------KFGYLPATG 292
           V  P   A      GP  P         PGE G  GA   +G+        K G     G
Sbjct: 501 VAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAG 560

Query: 293 DGPQPGSP--------CGPVGFPVPSG-----GESLSSAAQAPPQSAALCLGASAQASAE 339
              +PG P         G +GFP P G     G++       PP  A    G   +A A+
Sbjct: 561 QDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPP-GAVGPAGKDGEAGAQ 619

Query: 340 QQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREP-LGGLS 398
                     G      PA ++ E      P       QGL  PA     + +P   G+ 
Sbjct: 620 ----------GPPGPAGPAGERGEQGPAGSPGF-----QGLPGPAGPPGEAGKPGEQGVP 664

Query: 399 SSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDN----SHQDRPEEPS 454
             L         G    +R   G + ++  P P A  RG + +  N         P  P 
Sbjct: 665 GDLGAPGPSGARG----ERGFPGERGVQGPPGP-AGPRGANGAPGNDGAKGDAGAPGAPG 719

Query: 455 PGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPS 514
             G P L+ +    G   +     GP      A   G  G   P K  V      +  P 
Sbjct: 720 SQGAPGLQGMPGERGAAGL----PGPKGDRGDAGPKGADGS--PGKDGVRGLTGPIGPPG 773

Query: 515 PAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSD--- 571
           PA     K      GPAG    + +P  G  G+PG       PP     A G P +D   
Sbjct: 774 PAGAPGDKGESGPSGPAGPTGARGAP--GDRGEPG-------PPGPAGFA-GPPGADGQP 823

Query: 572 PACSQSGPMEAEEDSLPEQPEDSA 595
            A  + G   A+ D+ P  P   A
Sbjct: 824 GAKGEPGDAGAKGDAGPPGPAGPA 847



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 20/60 (33%), Positives = 22/60 (36%)

Query: 254 GPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGE 313
           GP  PP P      PG  G  G+    G   F         P P    GP G P P+G E
Sbjct: 845 GPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKE 904



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 98/420 (23%), Positives = 129/420 (30%), Gaps = 62/420 (14%)

Query: 243  PPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCG 302
            PP         G   PP P      PG PG +G     G         TG   +PG   G
Sbjct: 870  PPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPR-----GETGPAGRPGE-VG 923

Query: 303  PVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEG----QAPA 358
            P G P P+ GE  S  A  P  +         Q  A Q+  V +     + G      P+
Sbjct: 924  PPGPPGPA-GEKGSPGADGPAGAPGT---PGPQGIAGQRGVVGLPGQRGERGFPGLPGPS 979

Query: 359  QDQEELEAKAQPASRG----RLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFM 414
             +  +         RG        GLA P     S RE   G   S   + S    G   
Sbjct: 980  GEPGKQGPSGASGERGPPGPMGPPGLAGPPG--ESGREGAPGAEGSPGRDGSPGAKGDRG 1037

Query: 415  EQRRS--KGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKL 472
            E   +   G       P P        +S D           P G         P G + 
Sbjct: 1038 ETGPAGPPGAPGAPGAPGPVGP---AGKSGDRGETGPAGPAGPVG---------PVGAR- 1084

Query: 473  VCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPM-VQGPA 531
                  GP          G+ G Q    ++       +  P        ++ P    GPA
Sbjct: 1085 ------GPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPA 1138

Query: 532  GCQVFQPSPSGGTAGDPG-----GLSDPFYPP----RSGSLA-LGDPSSDPACSQSGPME 581
            G     P    G+AG PG     GL  P  PP    R+G    +G P         GP  
Sbjct: 1139 G-----PRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPS 1193

Query: 582  AEED--SLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEG 639
            A  D   LP+ P++ A    +    Y      VVR     + T L+ L   + +    EG
Sbjct: 1194 AGFDFSFLPQPPQEKA---HDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEG 1250



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 43/124 (34%), Positives = 49/124 (39%), Gaps = 31/124 (25%)

Query: 230  QSPRGDNLLSVGDPPQVAD--------LESLGGPCRPP-SPKDTG----SGPGEPGGS-G 275
            Q PRGD     G+  +  D           L GP  PP SP + G    SGP  P G  G
Sbjct: 1090 QGPRGDK----GETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPG 1145

Query: 276  AGCASGTEKFGYLPA----------TGD-GPQ-PGSPCGPVGFP-VPSGGESLSSAAQAP 322
            +  A G +    LP           TGD GP  P  P GP G P  PS G   S   Q P
Sbjct: 1146 SAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPP 1205

Query: 323  PQSA 326
             + A
Sbjct: 1206 QEKA 1209



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 25/75 (33%), Positives = 30/75 (40%), Gaps = 2/75 (2%)

Query: 238 LSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKF-GYLPATGDGPQ 296
           + V  PP  A  E   G    P P      PGE GG G+    G +   G     G+   
Sbjct: 454 VGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGS 513

Query: 297 PGSPCGPVGFPVPSG 311
           PG P GP G P  +G
Sbjct: 514 PG-PAGPKGSPGEAG 527



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 23/63 (36%), Positives = 23/63 (36%), Gaps = 3/63 (4%)

Query: 259 PSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSA 318
           P P       G PG  G   A G    G   A GD   PG P GP G P P G      A
Sbjct: 805 PGPPGPAGFAGPPGADGQPGAKGEP--GDAGAKGDAGPPG-PAGPAGPPGPIGNVGAPGA 861

Query: 319 AQA 321
             A
Sbjct: 862 KGA 864



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 31/103 (30%), Positives = 41/103 (39%), Gaps = 21/103 (20%)

Query: 230 QSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTE----KF 285
           + PRG+     G P +V       GP  PP P      PG  G +GA    G +    + 
Sbjct: 907 KGPRGETG-PAGRPGEV-------GPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQR 958

Query: 286 GYLPATGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPP 323
           G +   G   + G P    G P PSG     G S +S  + PP
Sbjct: 959 GVVGLPGQRGERGFP----GLPGPSGEPGKQGPSGASGERGPP 997



 Score = 31.2 bits (69), Expect = 6.3
 Identities = 29/107 (27%), Positives = 31/107 (28%), Gaps = 14/107 (13%)

Query: 230 QSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFG--Y 287
           +SP       V  P          GP  PP        PG PG  G     G    G  +
Sbjct: 100 ESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNF 159

Query: 288 LPATGDG-----------PQPGSPCGPVGFPVPSGGESLSSAAQAPP 323
            P    G           P P  P GP G P P G        Q PP
Sbjct: 160 APQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPG-PQGFQGPP 205


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 67/284 (23%), Positives = 101/284 (35%), Gaps = 43/284 (15%)

Query: 312  GESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD--QEELEAKAQ 369
            GE+  +   A P+S  +    + +A  E QEA   V+    E    ++D   +E E +AQ
Sbjct: 2039 GETQKTEGDAQPESDGV---EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQ 2095

Query: 370  PASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGP 429
            P S G         A        P     +  ++E   A       Q  S+G +      
Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVE------ 2149

Query: 430  VPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAIS 489
               AQD     +   S     +E      P LE V+ P           G        I 
Sbjct: 2150 ---AQD-AEGEAQPESEGIEAQEAEEEAQPELEGVEAPEA--------EGEAQPESEGIE 2197

Query: 490  HGQAGGQLPPKLEVLE--DLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGD 547
              +A G+  P+LE +E  +  E + P P       + P  +G A     QP   G T G+
Sbjct: 2198 APEAEGEAQPELEGVEAPEAEEEAQPEP----EGVETPEAEGEA-----QPESEGETQGE 2248

Query: 548  PGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQP 591
              G         S  ++LGD  S+ A   S P+  +  + P  P
Sbjct: 2249 KKG---------SPQVSLGDGQSEEASESSSPVPEDRPTPPPSP 2283



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 64/299 (21%), Positives = 97/299 (32%), Gaps = 19/299 (6%)

Query: 312  GESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPA 371
            GE   +  +A P+S  +    +   +  + E V       +  +A   +  E E +AQP 
Sbjct: 2069 GEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPE 2128

Query: 372  SRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVP 431
            S     +G+ AP     +  E  G  +   + EA     G   ++   +    L+    P
Sbjct: 2129 S-----EGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAP 2183

Query: 432  CAQDRGTDRSSDNSHQDRPEEPSPG----GCPRLEEVKIPHGVKLVCYLGSGPVIQLLGA 487
             A+      S      +   E  P       P  EE   P    +      G        
Sbjct: 2184 EAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEG 2243

Query: 488  ISHGQAGGQLPPKLEV----LEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGG 543
             + G+  G   P++ +     E+  E SSP P  R      P    P      Q  PS  
Sbjct: 2244 ETQGEKKGS--PQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSS 2301

Query: 544  TAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKP 602
             A   G     +         LGD  S P    +G   AE  +    PE S   Q+E P
Sbjct: 2302 RASSWGNC---WQKDSENDHVLGDTRS-PDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 154/656 (23%), Positives = 209/656 (31%), Gaps = 155/656 (23%)

Query: 7    VEGPSTGDPV----LSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVR-----AGSRR 57
            ++G   G P     L+P+   E     EGASS    S      SS  G R       +R 
Sbjct: 507  IDGAGLGGPEQGGRLTPRARSE-----EGASSDSSASTGSHEGSSEWGGRPQGCPGKARA 561

Query: 58   KIPRKEALRGG--SSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALT 115
            +  ++EA  GG  +S A   + +R    +L A  Q +G+  A G             A+T
Sbjct: 562  ETSQQEASEGGDPASPALSLSSLRSD--DLQAETQGQGTEQATGA------------AVT 607

Query: 116  SKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSP 175
             + L + L    D          S G       C     G       R   +R   MSSP
Sbjct: 608  REPLVLGLSCSWD----------SEGASSTPSTCTSSQQGQ------RRHRSRASAMSSP 651

Query: 176  GCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGD 235
                 SP L +  P G P            R    R+  HS  +        + + P   
Sbjct: 652  S----SPGLGRVAPRGHP------------RHSHYRKDTHSPLDSSVTK--QVPRPPERR 693

Query: 236  NLLSVGDPPQVADLES-----LGGPCRPPSPKDTGSGPGEP--GGSGAGCA--------S 280
                 G  P+ +   S       G  RPPS   +GS P +   G S A           S
Sbjct: 694  RACQDGSVPRYSGSSSSTRTQASGNLRPPS---SGSLPSQDLLGTSSATVTPAVHSDFVS 750

Query: 281  GTEKFGYLPATGDGPQPGSPCGPVGFPV-------PSGGESLSSAAQAPPQSAA---LCL 330
            G        A   G      C P   P         SG  SL   A+  PQ ++   L +
Sbjct: 751  GVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQV 810

Query: 331  GASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADT---- 386
            G   Q +     + C     S  G  PAQ     EA+  P+       G   P       
Sbjct: 811  GRPEQGAVGPHRSHCC----SQPGTQPAQ-----EAQRGPSPEASWLCGRYCPTPPRGRP 861

Query: 387  CASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSH 446
            C   R    G + S     +R   G   E  R       + GP P            NS 
Sbjct: 862  CPQRRSSSCGSTGSSHQSTARGPGGSPQEGTR-------QPGPTPSP--------GPNSG 906

Query: 447  QDRPEEPSPGGCPR-LEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLP---PKLE 502
              R    S G   R L E K           G GP  Q     + G +   LP   P+  
Sbjct: 907  ASRRSSASQGAGSRGLSEEKTLRS-------GGGPQGQ---EEASGVSPSSLPRSSPEAV 956

Query: 503  VLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGS 562
            V E L  +  P     +  +      G AG  +  P    G      GL +P    ++G 
Sbjct: 957  VREWLDNI--PEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEP---AQAGQ 1011

Query: 563  LAL-GDPSSDP-------ACSQSGPMEAE-------EDSLPEQPEDSAQLQQEKPS 603
             +L GDP  DP         S +GP   E        + + E P + A   +E P+
Sbjct: 1012 QSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAE-AGADREAPA 1066


>gi|79750944 ubiquitin specific peptidase 42 [Homo sapiens]
          Length = 1316

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 78/302 (25%), Positives = 111/302 (36%), Gaps = 42/302 (13%)

Query: 172  MSSPGCDRRSPTLSKEEP-PGRPLTSS---PDPVPVRVRKKWR---RQGAHSECEEGAGD 224
            MS+PG +R  P     EP PG P   S   PD        K     R       +EGA +
Sbjct: 733  MSAPGAERGPPEDRDAEPQPGSPAAESLEEPDAAAGLSSTKKAPPPRDPGTPATKEGAWE 792

Query: 225  FLWL--DQSP--RGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCAS 280
             + +  ++ P   G++++    PP + D  SL G   P S      G    G   +  A 
Sbjct: 793  AMAVAPEEPPPSAGEDIVGDTAPPDLCDPGSLTGDASPLS--QDAKGMIAEGPRDSALAE 850

Query: 281  GTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQ 340
              E     P      +   PC       PSG  +    AQ P QS    LGA   A    
Sbjct: 851  APEGLSPAPPA----RSEEPCEQPLLVHPSGDHARD--AQDPSQS----LGAPEAAERPP 900

Query: 341  QEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGL--- 397
               + +   G  EG A     E +E  A P + G       +PA      +E +G L   
Sbjct: 901  APVLDMAPAGHPEGDAEPSPGERVEDAAAPKAPG------PSPA------KEKIGSLRKV 948

Query: 398  -SSSLDTEASRACSGPFMEQRRSK--GTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPS 454
                  +   R+ SG    + RSK  G ++ ++   P  +DR  DR +   H    +  S
Sbjct: 949  DRGHYRSRRERSSSGEPARESRSKTEGHRHRRRRTCPRERDR-QDRHAPEHHPGHGDRLS 1007

Query: 455  PG 456
            PG
Sbjct: 1008 PG 1009


>gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]
          Length = 1745

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 111/444 (25%), Positives = 143/444 (32%), Gaps = 69/444 (15%)

Query: 166  EARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSP--DPVPVRVRKKWRRQGAHS----ECE 219
            E   G + +PG            PPG+P    P   P P        R+G       + +
Sbjct: 1075 EGDKGDVGAPGHKGSKGDKGDAGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLFGQKGD 1134

Query: 220  EGAGDFLWLDQSPRGDNLLSV-GDPPQVADLESLG-----GPCRPPSPKDTGSGPGEPGG 273
            +G   F+ +   P    L    G+  +V D+ S+G     GP  P  P  +   PG PGG
Sbjct: 1135 DGVRGFVGVIGPPGLQGLPGPPGEKGEVGDVGSMGPHGAPGPRGPQGPTGSEGTPGLPGG 1194

Query: 274  SGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPPQSAAL 328
             G   A G +        GD   PG P  P G P P G     G+S  S A  PP     
Sbjct: 1195 VGQPGAVGEK-----GERGDAGDPGPPGAP-GIPGPKGDIGEKGDSGPSGAAGPPGKK-- 1246

Query: 329  CLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCA 388
              G   +  A+      V  TG      P  D         P  +G        P D   
Sbjct: 1247 --GPPGEDGAKGS----VGPTGLPGDLGPPGDPGVSGIDGSPGEKG-------DPGDVGG 1293

Query: 389  SSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQD 448
                   G   +      R  SG  M +   +G K  K  P P   D    R+     + 
Sbjct: 1294 PGPPGASGEPGAPGPPGKRGPSG-HMGREGREGEKGAKGEPGP---DGPPGRTGPMGARG 1349

Query: 449  RPEEPSPGGCPRLEEVKIPHGVKLVCYLGS-------GPVIQLLGAISHGQAGGQLPPKL 501
             P    P G        IP  V     LG+       GP    LG        G   PK 
Sbjct: 1350 PPGRVGPEGLR-----GIPGPVGEPGLLGAPGQMGPPGP----LGPSGLPGLKGDTGPKG 1400

Query: 502  EV--LEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPR 559
            E   +  +  +  P  A     +  P VQGP G     P    G  G  G L  P  P  
Sbjct: 1401 EKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPG-----PKGDPGPPGPIGSLGHPGPPGV 1455

Query: 560  SGSL----ALGDPSSDPACSQSGP 579
            +G L    + G P S      +GP
Sbjct: 1456 AGPLGQKGSKGSPGSMGPRGDTGP 1479



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 26/83 (31%), Positives = 32/83 (38%), Gaps = 5/83 (6%)

Query: 243  PPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP-- 300
            PP     + + GP  P  P       GE G  G   A G +  G     GD   PG P  
Sbjct: 1047 PPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHK--GSKGDKGDAGPPGQPGI 1104

Query: 301  CGPVGFPVPSGGESLSSAAQAPP 323
             GP G P P G +  +   + PP
Sbjct: 1105 RGPAGHPGPPGADG-AQGRRGPP 1126



 Score = 31.6 bits (70), Expect = 4.8
 Identities = 45/162 (27%), Positives = 59/162 (36%), Gaps = 21/162 (12%)

Query: 169 DGGMSSPGCDRRSPTLSKEEPPGRPLTSSPD--PVPVRVRKKWRRQGAHSEC-EEGAGDF 225
           DG +  PG +  +     + PPG   ++ P   P P  V+     +G   E  E+G   F
Sbjct: 679 DGPLGHPGHEGPTGEKGAQGPPG---SAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDGF 735

Query: 226 LWL--DQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTE 283
                D   +GD        P+  D         P  PK      GE G  G+    G  
Sbjct: 736 PGFKGDVGLKGDQGKPGAPGPRGED--------GPEGPKGQAGQAGEEGPPGSAGEKG-- 785

Query: 284 KFGYLPATGDGPQPGSPCGPVGFPVPSG--GESLSSAAQAPP 323
           K G     G   +PG P G +GFP P G  GE   S     P
Sbjct: 786 KLGVPGLPGYPGRPG-PKGSIGFPGPLGPIGEKGKSGKTGQP 826


>gi|29725624 collagen, type XXIII, alpha 1 [Homo sapiens]
          Length = 540

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 77/282 (27%), Positives = 104/282 (36%), Gaps = 34/282 (12%)

Query: 48  GPGVRAGSRRKIPRKEALRGGSS-RAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPS 106
           GPG RAG      +  A  GG   R+A  A  R   +  L ++ S GS  A  L + + +
Sbjct: 2   GPGERAGGGGDAGKGNAAGGGGGGRSATTAGSR--AVSALCLLLSVGSAAAC-LLLGVQA 58

Query: 107 VPTQGR--ALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRP 164
              QGR  AL  +R      ++L  + P       A  P      RE+L G+ ++   R 
Sbjct: 59  AALQGRVAALEEER------ELLRRAGPPGALDAWAE-PHLERLLREKLDGLAKIRTAR- 110

Query: 165 REARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGA-G 223
            EA    +  PG   R     +   PG P  S  D  P  +    +      + E+GA G
Sbjct: 111 -EAPSECVCPPGPPGRRGKPGRRGDPGPPGQSGRDGYPGPLGLDGKPGLPGPKGEKGAPG 169

Query: 224 DFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTE 283
           DF      PRGD              +   GP  PP P      PG+ G  G   A G  
Sbjct: 170 DF-----GPRGDQ-----------GQDGAAGPPGPPGPPGARGPPGDTGKDGPRGAQGPA 213

Query: 284 KFGYLPATGDGPQPGSPCGPVGFPVPSG--GESLSSAAQAPP 323
                P       P  P GP G P   G  G+  + +   PP
Sbjct: 214 GPKGEPGQDGEMGPKGPPGPKGEPGVPGKKGDDGTPSQPGPP 255



 Score = 32.0 bits (71), Expect = 3.7
 Identities = 25/70 (35%), Positives = 29/70 (41%), Gaps = 2/70 (2%)

Query: 243 PPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPAT-GDGPQPGSPC 301
           PP    L+ + GP      K      GE G SG     G      LP T G+  +PG P 
Sbjct: 419 PPGPMGLQGIQGPKGLDGAKGEKGASGERGPSGLPGPVGPPGLIGLPGTKGEKGRPGEP- 477

Query: 302 GPVGFPVPSG 311
           G  GFP P G
Sbjct: 478 GLDGFPGPRG 487



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 31/103 (30%), Positives = 38/103 (36%), Gaps = 7/103 (6%)

Query: 249 LESLGGPCRPPSPKDTGSGPGEPGGSG-AGCASGTEKFGYLPATGDGPQPGSPCGPVGFP 307
           L++L GP   P P+     PG PG  G  G        G     G    PG P GP G  
Sbjct: 316 LDALKGP---PGPQGPPGPPGIPGAKGELGLPGAPGIDGEKGPKGQKGDPGEP-GPAGLK 371

Query: 308 VPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTG 350
             +G   LS    A         G SA  S ++  A  +V  G
Sbjct: 372 GEAGEMGLSGLPGADGLKGE--KGESASDSLQESLAQLIVEPG 412


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/82 (32%), Positives = 31/82 (37%)

Query: 241 GDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSP 300
           G PP VA      GP  PP P+      G PGG GA    G       P +   P P  P
Sbjct: 836 GGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGP 895

Query: 301 CGPVGFPVPSGGESLSSAAQAP 322
            G  G   P G    + A  +P
Sbjct: 896 SGSPGKDGPPGPAGNTGAPGSP 917



 Score = 40.4 bits (93), Expect = 0.010
 Identities = 88/413 (21%), Positives = 130/413 (31%), Gaps = 35/413 (8%)

Query: 154 AGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQG 213
           AG+  V   +  + +DG    PG +       +   PG    + P+ +P        R  
Sbjct: 452 AGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGA 511

Query: 214 AHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGG 273
                  GA      D  P G  +  +   P     +   GP   P  +     PG PG 
Sbjct: 512 PGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGP---PGSQGESGRPGPPGP 568

Query: 274 SGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSG--GESLSSAAQAPPQSAALCLG 331
           SG     G   F         P      G  G P P G  G++  +  Q PP        
Sbjct: 569 SGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGD 628

Query: 332 ASAQASAEQQEAVCVVRTGSDEGQ--APAQDQEELEAKAQPASRGRLEQGLAAPADTCAS 389
                    Q    +  TG   G+   P +   + +A A  A  G+ + G          
Sbjct: 629 KGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGL 688

Query: 390 SREP-LGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQD 448
           +  P L G +     E  +  +GP      + GT  L+  P    +  G         + 
Sbjct: 689 AGAPGLRGGAGPPGPEGGKGAAGP-PGPPGAAGTPGLQGMP---GERGGLGSPGPKGDKG 744

Query: 449 RPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLM 508
            P  P   G P  +  + P          +GP+     A   G  G    P       L 
Sbjct: 745 EPGGPGADGVPGKDGPRGP----------TGPIGPPGPAGQPGDKGEGGAP------GLP 788

Query: 509 EVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSG 561
            ++ P  +   R +  P   GPAG   F  +P  G  G+PGG  +   P   G
Sbjct: 789 GIAGPRGSPGERGETGP--PGPAG---FPGAP--GQNGEPGGKGERGAPGEKG 834



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 40/142 (28%), Positives = 48/142 (33%), Gaps = 25/142 (17%)

Query: 170 GGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLD 229
           G    PG   R+        PG P   SP P            G    C  G  ++    
Sbjct: 109 GDPGPPGIPGRNGDPGIPGQPGSP--GSPGP-----------PGICESCPTGPQNY---- 151

Query: 230 QSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLP 289
            SP+ D+   V     V  L    GP  PP P      PG PG SG   + G+  +   P
Sbjct: 152 -SPQYDSY-DVKSGVAVGGLAGYPGPAGPPGP------PGPPGTSGHPGSPGSPGYQGPP 203

Query: 290 ATGDGPQPGSPCGPVGFPVPSG 311
                  P  P GP G   PSG
Sbjct: 204 GEPGQAGPSGPPGPPGAIGPSG 225



 Score = 35.4 bits (80), Expect = 0.33
 Identities = 53/234 (22%), Positives = 69/234 (29%), Gaps = 29/234 (12%)

Query: 232  PRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPAT 291
            P  + L     PP    L  L G    P         G PG  G+    G       P  
Sbjct: 983  PGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGA 1042

Query: 292  GDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGS 351
               P    P GPVG P    G+   S    P        GA   A +           G+
Sbjct: 1043 PGAPGHPGPPGPVG-PAGKSGDRGESGPAGP-------AGAPGPAGSR----------GA 1084

Query: 352  DEGQAPAQDQEELEAKAQPASRGR--LEQGLAAPADTCASSREPLGGLSSSLDTEASRAC 409
               Q P  D+ E   +     +G         AP     + ++   G             
Sbjct: 1085 PGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGP 1144

Query: 410  SGPFMEQRRSKGTKNLKKGPVPCAQDRGT--DRSSDNS--HQDRPEEPSPGGCP 459
            SGP       K   +   GP+     RG   +R S+ S  H  +P  P P G P
Sbjct: 1145 SGP-----PGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAP 1193



 Score = 34.7 bits (78), Expect = 0.57
 Identities = 25/61 (40%), Positives = 26/61 (42%), Gaps = 6/61 (9%)

Query: 254 GPCRPPSPKDTGSGPG---EPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPS 310
           G   PP P      PG   EPGG G   A G +  G  P    GP  GS  GP G P P 
Sbjct: 801 GETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVA-GPPGGS--GPAGPPGPQ 857

Query: 311 G 311
           G
Sbjct: 858 G 858



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 27/86 (31%), Positives = 32/86 (37%), Gaps = 4/86 (4%)

Query: 244 PQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPG--SPC 301
           P +     L G    P P      PGE G  G   A+G    G   A G   QPG   P 
Sbjct: 281 PGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGAR--GNDGARGSDGQPGPPGPP 338

Query: 302 GPVGFPVPSGGESLSSAAQAPPQSAA 327
           G  GFP   G +     A +P  + A
Sbjct: 339 GTAGFPGSPGAKGEVGPAGSPGSNGA 364



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 18/54 (33%), Positives = 20/54 (37%)

Query: 258 PPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSG 311
           PP P  T   PG PG  G    +G+      P     P P    G  G P P G
Sbjct: 334 PPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPG 387



 Score = 31.2 bits (69), Expect = 6.3
 Identities = 31/90 (34%), Positives = 33/90 (36%), Gaps = 10/90 (11%)

Query: 243 PPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQ-----P 297
           PP  A      G    P  K     PGE G  G    +G    G  PA   GPQ      
Sbjct: 805 PPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPG-GSGPAGPPGPQGVKGER 863

Query: 298 GSPCGP--VGFPVPSG--GESLSSAAQAPP 323
           GSP GP   GFP   G  G   S+    PP
Sbjct: 864 GSPGGPGAAGFPGARGLPGPPGSNGNPGPP 893



 Score = 31.2 bits (69), Expect = 6.3
 Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 3/65 (4%)

Query: 258 PPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSS 317
           PP P      PG PG SG    +G    G   + G    PG+P GP+G    +G   L+ 
Sbjct: 904 PPGPAGNTGAPGSPGVSGPKGDAGQP--GEKGSPGAQGPPGAP-GPLGIAGITGARGLAG 960

Query: 318 AAQAP 322
               P
Sbjct: 961 PPGMP 965



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 23/64 (35%), Positives = 26/64 (40%), Gaps = 10/64 (15%)

Query: 529 GPAGCQVFQPSPSG--GTAGDPGGLSDPFYPPRSGSLALGDPSSDP----ACSQSGPMEA 582
           GPAG     P P G  GT+G PG    P Y    G      PS  P    A   SGP   
Sbjct: 174 GPAG----PPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGK 229

Query: 583 EEDS 586
           + +S
Sbjct: 230 DGES 233


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo
           sapiens]
          Length = 2462

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 50/187 (26%), Positives = 73/187 (39%), Gaps = 19/187 (10%)

Query: 254 GPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFP--VPSG 311
           GP  P +    G  PG P        + TE      ATG    P +P  P   P  VP  
Sbjct: 749 GPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE 808

Query: 312 GESLSSAAQAPPQS-------AALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEEL 364
            +   +AA  P +        AA  L      + E  ++ C     ++EG A  +D E  
Sbjct: 809 EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE--AEEGPAKGKDAEAA 866

Query: 365 EAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKN 424
           EA A+ A +   ++G +  A T  SS  P        D+++S  CS   +++    G KN
Sbjct: 867 EATAEGALKAEKKEGGSGRATTAKSSGAP-------QDSDSSATCSADEVDEAEG-GDKN 918

Query: 425 LKKGPVP 431
               P P
Sbjct: 919 RLLSPRP 925


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo
           sapiens]
          Length = 2524

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 50/187 (26%), Positives = 73/187 (39%), Gaps = 19/187 (10%)

Query: 254 GPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFP--VPSG 311
           GP  P +    G  PG P        + TE      ATG    P +P  P   P  VP  
Sbjct: 766 GPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKE 825

Query: 312 GESLSSAAQAPPQS-------AALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEEL 364
            +   +AA  P +        AA  L      + E  ++ C     ++EG A  +D E  
Sbjct: 826 EKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEE--AEEGPAKGKDAEAA 883

Query: 365 EAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKN 424
           EA A+ A +   ++G +  A T  SS  P        D+++S  CS   +++    G KN
Sbjct: 884 EATAEGALKAEKKEGGSGRATTAKSSGAP-------QDSDSSATCSADEVDEAEG-GDKN 935

Query: 425 LKKGPVP 431
               P P
Sbjct: 936 RLLSPRP 942


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 99/409 (24%), Positives = 141/409 (34%), Gaps = 71/409 (17%)

Query: 231  SPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPA 290
            SP G    S   PP         G  +  +P   G  PG P     G   G    G  P 
Sbjct: 624  SPAGYKTASPPGPPPYGKRAPSPGAYKTATPP--GYKPGSPPSFRTGTPPGYR--GTSPP 679

Query: 291  TGDGP-QPGSPC---GPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCV 346
             G G  +PGSP    GP+    PSG  SL     AP     L      Q  AE+ E    
Sbjct: 680  AGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYE---T 736

Query: 347  VRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSR---EPLGGLS----- 398
              +     ++P+   + ++  +  +   R  + L    ++CA S     PL G       
Sbjct: 737  PESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKR 796

Query: 399  SSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGC 458
            + L  +  R       E++  +  +  +K      ++R  +R  + S +   E  +P  C
Sbjct: 797  ADLVEKVRREAEQRAREEKEREREREREK-----EREREKERELERSVKLAQEGRAPVEC 851

Query: 459  PRLEEVKIPHG---------VKLVCYLG-----------------------SGPVIQLLG 486
            P L  V  PH            +  YLG                       + P    LG
Sbjct: 852  PSLGPV--PHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLG 909

Query: 487  AISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAG 546
            A+  G  G  +P          E    +  + LR + +P      G +V +PS      G
Sbjct: 910  AVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKP------GFEV-KPSELEPLHG 962

Query: 547  DPGGLSDPFYPPRSGSLAL--GDPSSD--PACSQSGPMEAEEDSLPEQP 591
             PG   DPF  PR G LAL  G P     P     GP+E E  +L   P
Sbjct: 963  VPGPGLDPF--PRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGP 1009



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 81/366 (22%), Positives = 109/366 (29%), Gaps = 64/366 (17%)

Query: 258 PPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATG-DGPQPGSPCGPVGFPVPSGGESLS 316
           PP+ +   +    P G GA    G     +    G  G  PG   GP   P P      S
Sbjct: 304 PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363

Query: 317 SAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRL 376
           S+A APP        +S+ A+A                 + +       A   PAS+   
Sbjct: 364 SSAPAPPMRFPYSSSSSSSAAA-----------------SSSSSSSSSSASPFPASQALP 406

Query: 377 EQGLAAPADTCAS-SREPLGGLSSSLDTEA------------------SRACSGPFMEQR 417
               + P  T  S S +P      SL ++A                  S A  GPF    
Sbjct: 407 SYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPP-- 464

Query: 418 RSKGTKNLKKGPVPC-----------AQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKI 466
            S G ++    PV              Q +   +     H      P PG  P   E   
Sbjct: 465 -STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGS 523

Query: 467 PHGVKLVCYLGSGPVIQLLGAISHGQAG-GQLPPKLEVLEDLMEVSSPSPAQRLRRKKRP 525
            H         S      LG++     G   LPP    +       +  P          
Sbjct: 524 SHHAHPYAMSPS------LGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSS 577

Query: 526 MVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEED 585
             QG   C    PSPS G    P G   PF P  + + +    S+  A   S P   +  
Sbjct: 578 TSQGSYPCS--HPSPSQG----PQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTA 631

Query: 586 SLPEQP 591
           S P  P
Sbjct: 632 SPPGPP 637


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 99/409 (24%), Positives = 141/409 (34%), Gaps = 71/409 (17%)

Query: 231  SPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPA 290
            SP G    S   PP         G  +  +P   G  PG P     G   G    G  P 
Sbjct: 624  SPAGYKTASPPGPPPYGKRAPSPGAYKTATPP--GYKPGSPPSFRTGTPPGYR--GTSPP 679

Query: 291  TGDGP-QPGSPC---GPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCV 346
             G G  +PGSP    GP+    PSG  SL     AP     L      Q  AE+ E    
Sbjct: 680  AGPGTFKPGSPTVGPGPLPPAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYE---T 736

Query: 347  VRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSR---EPLGGLS----- 398
              +     ++P+   + ++  +  +   R  + L    ++CA S     PL G       
Sbjct: 737  PESPVPPARSPSPPPKVVDVPSHASQSARFNKHLDRGFNSCARSDLYFVPLEGSKLAKKR 796

Query: 399  SSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGC 458
            + L  +  R       E++  +  +  +K      ++R  +R  + S +   E  +P  C
Sbjct: 797  ADLVEKVRREAEQRAREEKEREREREREK-----EREREKERELERSVKLAQEGRAPVEC 851

Query: 459  PRLEEVKIPHG---------VKLVCYLG-----------------------SGPVIQLLG 486
            P L  V  PH            +  YLG                       + P    LG
Sbjct: 852  PSLGPV--PHRPPFEPGSAVATVPPYLGPDTPALRTLSEYARPHVMSPGNRNHPFYVPLG 909

Query: 487  AISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAG 546
            A+  G  G  +P          E    +  + LR + +P      G +V +PS      G
Sbjct: 910  AVDPGLLGYNVPALYSSDPAAREREREARERDLRDRLKP------GFEV-KPSELEPLHG 962

Query: 547  DPGGLSDPFYPPRSGSLAL--GDPSSD--PACSQSGPMEAEEDSLPEQP 591
             PG   DPF  PR G LAL  G P     P     GP+E E  +L   P
Sbjct: 963  VPGPGLDPF--PRHGGLALQPGPPGLHPFPFHPSLGPLERERLALAAGP 1009



 Score = 32.7 bits (73), Expect = 2.2
 Identities = 81/366 (22%), Positives = 109/366 (29%), Gaps = 64/366 (17%)

Query: 258 PPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATG-DGPQPGSPCGPVGFPVPSGGESLS 316
           PP+ +   +    P G GA    G     +    G  G  PG   GP   P P      S
Sbjct: 304 PPALRPLNNASASPPGLGAQPLPGHLPSPHAMGQGMGGLPPGPEKGPTLAPSPHSLPPAS 363

Query: 317 SAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRL 376
           S+A APP        +S+ A+A                 + +       A   PAS+   
Sbjct: 364 SSAPAPPMRFPYSSSSSSSAAA-----------------SSSSSSSSSSASPFPASQALP 406

Query: 377 EQGLAAPADTCAS-SREPLGGLSSSLDTEA------------------SRACSGPFMEQR 417
               + P  T  S S +P      SL ++A                  S A  GPF    
Sbjct: 407 SYPHSFPPPTSLSVSNQPPKYTQPSLPSQAVWSQGPPPPPPYGRLLANSNAHPGPFPP-- 464

Query: 418 RSKGTKNLKKGPVPC-----------AQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKI 466
            S G ++    PV              Q +   +     H      P PG  P   E   
Sbjct: 465 -STGAQSTAHPPVSTHHHHHQQQQQQQQQQQQQQQQQQQHHGNSGPPPPGAFPHPLEGGS 523

Query: 467 PHGVKLVCYLGSGPVIQLLGAISHGQAG-GQLPPKLEVLEDLMEVSSPSPAQRLRRKKRP 525
            H         S      LG++     G   LPP    +       +  P          
Sbjct: 524 SHHAHPYAMSPS------LGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSS 577

Query: 526 MVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEED 585
             QG   C    PSPS G    P G   PF P  + + +    S+  A   S P   +  
Sbjct: 578 TSQGSYPCS--HPSPSQG----PQGAPYPFPPVPTVTTSSATLSTVIATVASSPAGYKTA 631

Query: 586 SLPEQP 591
           S P  P
Sbjct: 632 SPPGPP 637


>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
          Length = 844

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/187 (27%), Positives = 67/187 (35%), Gaps = 35/187 (18%)

Query: 257 RPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGS----------PCGPVGF 306
           R P+P   G GPG   G GA      + + Y PA G GP+ G+          P  P   
Sbjct: 643 RHPAPPGPGPGPGPGPGPGADMQRSYDSY-YYPAAGPGPRRGTCALGGSLGSLPASPFRI 701

Query: 307 PVPSGGESLSSAAQAPPQSAALCLGASAQASA-------------EQQEAVCV-----VR 348
           P     E+    A  PP       GAS + SA               Q A        + 
Sbjct: 702 PEDDEYETTQECAPPPPPRPR-ARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 760

Query: 349 TGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSS-----SLDT 403
           +GS  G A A D +  +A    A+      GL    D   S   PL   +      SLD+
Sbjct: 761 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 820

Query: 404 EASRACS 410
            ++RA S
Sbjct: 821 HSTRASS 827


>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
          Length = 852

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/187 (27%), Positives = 67/187 (35%), Gaps = 35/187 (18%)

Query: 257 RPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGS----------PCGPVGF 306
           R P+P   G GPG   G GA      + + Y PA G GP+ G+          P  P   
Sbjct: 651 RHPAPPGPGPGPGPGPGPGADMQRSYDSY-YYPAAGPGPRRGTCALGGSLGSLPASPFRI 709

Query: 307 PVPSGGESLSSAAQAPPQSAALCLGASAQASA-------------EQQEAVCV-----VR 348
           P     E+    A  PP       GAS + SA               Q A        + 
Sbjct: 710 PEDDEYETTQECAPPPPPRPR-ARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 768

Query: 349 TGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSS-----SLDT 403
           +GS  G A A D +  +A    A+      GL    D   S   PL   +      SLD+
Sbjct: 769 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 828

Query: 404 EASRACS 410
            ++RA S
Sbjct: 829 HSTRASS 835


>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
          Length = 858

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/187 (27%), Positives = 67/187 (35%), Gaps = 35/187 (18%)

Query: 257 RPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGS----------PCGPVGF 306
           R P+P   G GPG   G GA      + + Y PA G GP+ G+          P  P   
Sbjct: 657 RHPAPPGPGPGPGPGPGPGADMQRSYDSY-YYPAAGPGPRRGTCALGGSLGSLPASPFRI 715

Query: 307 PVPSGGESLSSAAQAPPQSAALCLGASAQASA-------------EQQEAVCV-----VR 348
           P     E+    A  PP       GAS + SA               Q A        + 
Sbjct: 716 PEDDEYETTQECAPPPPPRPR-ARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 774

Query: 349 TGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSS-----SLDT 403
           +GS  G A A D +  +A    A+      GL    D   S   PL   +      SLD+
Sbjct: 775 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 834

Query: 404 EASRACS 410
            ++RA S
Sbjct: 835 HSTRASS 841


>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
          Length = 850

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 51/187 (27%), Positives = 67/187 (35%), Gaps = 35/187 (18%)

Query: 257 RPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGS----------PCGPVGF 306
           R P+P   G GPG   G GA      + + Y PA G GP+ G+          P  P   
Sbjct: 649 RHPAPPGPGPGPGPGPGPGADMQRSYDSY-YYPAAGPGPRRGTCALGGSLGSLPASPFRI 707

Query: 307 PVPSGGESLSSAAQAPPQSAALCLGASAQASA-------------EQQEAVCV-----VR 348
           P     E+    A  PP       GAS + SA               Q A        + 
Sbjct: 708 PEDDEYETTQECAPPPPPRPR-ARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLS 766

Query: 349 TGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSS-----SLDT 403
           +GS  G A A D +  +A    A+      GL    D   S   PL   +      SLD+
Sbjct: 767 SGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDS 826

Query: 404 EASRACS 410
            ++RA S
Sbjct: 827 HSTRASS 833


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 104/464 (22%), Positives = 147/464 (31%), Gaps = 71/464 (15%)

Query: 170  GGMSSPGCDRRSPTLSKEEPP---GRPLTSSPD--PVPVRVRKKWRRQGAHSECEEGAGD 224
            GG+++P   + +PT     PP   G P T  P   P P        + G  +   +GA +
Sbjct: 1230 GGLATPS-PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPN 1288

Query: 225  -FLWLDQSPRGDNLLS----VGDPPQVADLESLGGP-------------CRPPSPKDTGS 266
              +    SP+G    S       PP        G P               PPSPK T +
Sbjct: 1289 PAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPT 1348

Query: 267  GPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSA 326
             P     S  G  + + K G  P        G P   +  P P  G ++ S    P   A
Sbjct: 1349 LPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPA--MTPPSPKRGPAIPSPKGDPTSPA 1406

Query: 327  ALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADT 386
             + L      S ++  A  V R G                 A   S+G     L  PA T
Sbjct: 1407 VIPL------SPKKAPATPVTREG-----------------AATPSKG----DLTPPAVT 1439

Query: 387  CASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSH 446
              S       L  +  T A +   GP     +   T      P P         ++ +S 
Sbjct: 1440 PVS-------LKKAPATSAPK--GGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSP 1490

Query: 447  QDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSG---PVIQLLGAISHGQAGGQLPPKLEV 503
            +  P  P+P G P L  V IP   K V    S    P+      +S  +    L PK  +
Sbjct: 1491 KKAPATPAPMGAPTLPAV-IPSSPKEVPATPSSRRDPIAPTATLLSK-KTPATLAPKEAL 1548

Query: 504  LEDLMEVSSPSPAQRLRRKKR----PMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPR 559
            +   M V SP     +   K     P  +  +      PS   G       L  P     
Sbjct: 1549 IPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSP 1608

Query: 560  SGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
            S   A   P+  P   + GP        P  P  +    ++ P+
Sbjct: 1609 SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPT 1652



 Score = 38.1 bits (87), Expect = 0.051
 Identities = 99/448 (22%), Positives = 131/448 (29%), Gaps = 61/448 (13%)

Query: 182  PTLSKEEPPGRPLTSSPD--PVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLS 239
            P  +   P G P T SP   P P        + G  +   +GA                 
Sbjct: 943  PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPT--------------- 987

Query: 240  VGDPPQVADLESLGGPCRP-------------PSPKDTGSGPGEPGGSGAGCASGTEKFG 286
               PP        GGP  P             PSPK + +    P G+    A+      
Sbjct: 988  ---PPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPK 1044

Query: 287  YLPATGDGPQPGSPCGPVG-FPVPSGGESLSSAAQAPPQSAAL---CLGASAQASAEQQE 342
              PA    P+ G+P  P    P P GG +  S   AP   AA      G  A  S +   
Sbjct: 1045 GSPAATPLPK-GAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAP 1103

Query: 343  AVCVVRTGSDEG---QAPAQDQEELEAKAQPASRGRL--EQGLAAPADTCASSREPLGGL 397
                    S +G     P +      A   P+ +G L       AP    A+   P GGL
Sbjct: 1104 MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL 1163

Query: 398  SSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGG 457
            ++     A    +      +    T + K  P        T  ++  S +     PSP G
Sbjct: 1164 ATPPPKGAPTTPAATPPSPKGGLATPSPKGAPT-------TPAATPPSPKGGLATPSPKG 1216

Query: 458  CPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQ 517
             P       P     +             A      GG   P  +        + PS   
Sbjct: 1217 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKG 1276

Query: 518  RLRRKKRPMVQGPAGCQVFQPSPSGGTAGDP--GGLSDPFYPPRSGSLALGDPSSDPACS 575
             L          PA   V  PSP GG A  P  G  + P   P S     G P + P   
Sbjct: 1277 GLATPPHKGAPNPA--VVTPPSPKGGPATSPPKGAPTPPAATPPSPK---GSPGTPPPKG 1331

Query: 576  QSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
               P        P  P+ +  L    PS
Sbjct: 1332 APTPPAV----TPPSPKGTPTLPATTPS 1355



 Score = 31.2 bits (69), Expect = 6.3
 Identities = 75/302 (24%), Positives = 101/302 (33%), Gaps = 57/302 (18%)

Query: 295 PQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEG 354
           P  G+P G       S   +L+  A +P +      GASA AS++         T   + 
Sbjct: 740 PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKG------TLTYLADS 793

Query: 355 QAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLD-TEASRACSGPF 413
            +P       + K  P  +G      +A  DT      P+G LSS +   EAS      F
Sbjct: 794 PSPLGVSVSPQTKRPPTKKG------SAGPDT------PIGNLSSPVSPVEAS------F 835

Query: 414 MEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVK--IPHGVK 471
           +              P      +G+  S   +H   P  PSP G P    V    P GV 
Sbjct: 836 L--------------PENSLSFQGSKDSPATTHS--PTPPSPKGAPTPSAVTPLSPKGVT 879

Query: 472 LVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKR-PMVQGP 530
           L       P +  L     G A    P   +     M  SSP  A+     K  P    P
Sbjct: 880 LPPKETPTPSVVNLPFPKEGPA---TPAPKQAPALSMTSSSPKKARATPAPKGIPASPSP 936

Query: 531 AGCQVFQPSPSGGTAGDP-GGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPE 589
            G     P+P   T   P GG + P     S   A   P++ P   + GP        P 
Sbjct: 937 KGA----PTPPAATPPSPKGGPATP-----SPKWAPTPPAATPPSPKGGPATPSPKGAPT 987

Query: 590 QP 591
            P
Sbjct: 988 PP 989


>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
          Length = 380

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 54/211 (25%), Positives = 79/211 (37%), Gaps = 42/211 (19%)

Query: 189 PPGRPLTSSPD-PVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVA 247
           PP  P  S P+ P P  V ++ R+Q   SE  E                + + G PP   
Sbjct: 121 PPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIER--------------RVSNAGGPPA-- 164

Query: 248 DLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFP 307
                GGP  PP P      P  PG   +G          +PA   G   G P  P   P
Sbjct: 165 --PPAGGPPPPPGPPPPPGPPPPPGLPPSG----------VPAAAHGAGGGPPPAP---P 209

Query: 308 VPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEA-----VCVVRTGSDEGQAPAQDQE 362
           +P+        A AP  +AA+  GA  +  ++Q+EA          +G   G    ++  
Sbjct: 210 LPAAQGPGGGGAGAPGLAAAIA-GAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMN 268

Query: 363 ELEAKAQPASRGRLEQGLAAPADTCASSREP 393
            + A+ + A+    + G   P D  A+  EP
Sbjct: 269 AMLARRRKAT----QVGEKTPKDESANQEEP 295


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 69/294 (23%), Positives = 108/294 (36%), Gaps = 52/294 (17%)

Query: 289  PATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVR 348
            PA  DGP P SP  P    V +      +   + P+S    L +     +E   ++    
Sbjct: 1018 PALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSL---- 1073

Query: 349  TGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCAS-----SREPLGGLSSSLDT 403
            +  +     A+ Q++L        +GRL   LA+ A + +S     + E L G  S  DT
Sbjct: 1074 SAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDT 1133

Query: 404  EASRACSGPFMEQRRSKGTKNLKKGPV------------PCAQDRGTDRSSDNSHQDRPE 451
             AS   +    +  R+  T++    P+            P ++  G   + D +   R +
Sbjct: 1134 PASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSRLQ 1193

Query: 452  EPSPGGCPRLEEV--KIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLP----PKLEVLE 505
              +P G     ++  K P G       G GP           QAG + P    P+L    
Sbjct: 1194 LQTPPGSATAADLRPKQPPG------RGLGP--------GRAQAGARPPAPRSPRLPAST 1239

Query: 506  DLMEVSSPSP-AQRLRRKK--------RPMVQGPAGCQVFQPSPSGGTAGDPGG 550
                 +S SP +Q L R++        RP V  P G    +  P G     PGG
Sbjct: 1240 SAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDG--TPSPGG 1291


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
           [Homo sapiens]
          Length = 1412

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 122/613 (19%), Positives = 218/613 (35%), Gaps = 82/613 (13%)

Query: 32  ASSMPGLSPDGPGASSGPGVRAG---SRRKIPR-KEALRGGSSRAAGAAEVRPGVLELLA 87
           A+S P     G GA+  P  +AG   S+ K  + +E     S  ++ + E  P    LL 
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 284

Query: 88  VVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERAL 147
              S  +             P +G A                + P    +++    E + 
Sbjct: 285 AKASGKTSQVGAASAPAKESPRKGAAPAPP----------GKTGPAVAKAQAGKREEDSQ 334

Query: 148 ACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEP-----PGRPLTSSPDPVP 202
           +  E     EE     P +A+  G +       +P  +KE P     P  P  + P    
Sbjct: 335 SSSEESDSEEEA----PAQAKPSGKAPQVRAASAP--AKESPRKGAAPAPPRKTGPAAAQ 388

Query: 203 VRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPK 262
           V+V K+   + + S  EE   D   L  +     +  +G  PQV    ++G       P 
Sbjct: 389 VQVGKQ--EEDSRSSSEESDSDREAL-AAMNAAQVKPLGKSPQVKPASTMG-----MGPL 440

Query: 263 DTGSGPGEPGGSGAGCASG-----------TEKFGYLPATGDGPQPGSPCGPVGFPVPSG 311
             G+GP  PG  G    S            + +     + G+ P   +P           
Sbjct: 441 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 500

Query: 312 GESLSSAAQAPPQSAA-LCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQP 370
            +  SS A+ PPQ A  + +   A+   +  E+       +D  +APA       A+A+P
Sbjct: 501 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAKP 557

Query: 371 ASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPV 430
           A +    +      +T AS++     + +    +A  A S        + GT+       
Sbjct: 558 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP----- 612

Query: 431 PCAQDRGTDRSSDNSHQDRP------EEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVI-- 482
             A+D  +   SD+  +         +  S G   +++   +P  VK     G+ PV+  
Sbjct: 613 --AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP--VKGSLGQGTAPVLPG 668

Query: 483 QLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQ-RLRRKKRPMVQGPAGCQVFQPSPS 541
           +    ++  +A  Q   +    E   E ++ SPAQ +   KK      PA  +   PS  
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--PSAK 726

Query: 542 GGTAG--------------DPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSL 587
           G  +                P  +  P   P++ ++    P+S P+  ++    A+  + 
Sbjct: 727 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 786

Query: 588 PEQPEDSAQLQQE 600
           PE+   S++ + +
Sbjct: 787 PEEDSGSSEEESD 799



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 96/466 (20%), Positives = 160/466 (34%), Gaps = 67/466 (14%)

Query: 174 SPGCDRRSPTLSKEEPPGRPLTSSPDPV-PVRVRKKWRRQGAHSECEEGAGDFLWLDQSP 232
           +P  ++    + + +P   P    P    PV V+ K  +   +SE  E + D    +++P
Sbjct: 488 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 547

Query: 233 RGDNLLSVGDPPQVADLESLG-----------GPCR--PPSPKDTGSGPGEPGGSGAGCA 279
                       ++   ++              P R    +P+  G+    P GS    A
Sbjct: 548 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS-PAGSSPAVA 606

Query: 280 SGTEKFGYLPA--TGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPPQSAALCLGA 332
            GT++    PA  +    +  S     G  V  G     G+ L   A + P   +L  G 
Sbjct: 607 GGTQR----PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 662

Query: 333 SAQASAEQQEAVCVVRTGSDEGQAPAQDQEELE-AKAQPA---SRGRLEQGLAAPADTCA 388
           +     +    V  V+    E    ++++ + E A A PA   +  +  Q  A PA   A
Sbjct: 663 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 722

Query: 389 SSREPLGGLSSSLDTEAS----RACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDN 444
            S +        + T A+    R+ S      R  + +  L +GP       G   ++  
Sbjct: 723 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS-VPSVGKAVATAA 781

Query: 445 SHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVL 504
             Q  PEE S  G    E         L     SG   Q+  A++        P K    
Sbjct: 782 QAQTGPEEDS--GSSEEESDSEEEAETLAQVKPSGKTHQIRAALA--------PAK---- 827

Query: 505 EDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGS-- 562
           E   + ++P+P         P   GP+  Q  +   SG ++ +    SD   P    S  
Sbjct: 828 ESPRKGAAPTP---------PGKTGPSAAQAGKQDDSGSSSEESD--SDGEAPAAVTSAQ 876

Query: 563 -----LALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
                L   DP+  PA   + P +A+  S P +   S    +   S
Sbjct: 877 VIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSS 922


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 122/613 (19%), Positives = 218/613 (35%), Gaps = 82/613 (13%)

Query: 32  ASSMPGLSPDGPGASSGPGVRAG---SRRKIPR-KEALRGGSSRAAGAAEVRPGVLELLA 87
           A+S P     G GA+  P  +AG   S+ K  + +E     S  ++ + E  P    LL 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 88  VVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERAL 147
              S  +             P +G A                + P    +++    E + 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPP----------GKTGPAVAKAQAGKREEDSQ 411

Query: 148 ACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEP-----PGRPLTSSPDPVP 202
           +  E     EE     P +A+  G +       +P  +KE P     P  P  + P    
Sbjct: 412 SSSEESDSEEEA----PAQAKPSGKAPQVRAASAP--AKESPRKGAAPAPPRKTGPAAAQ 465

Query: 203 VRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPK 262
           V+V K+   + + S  EE   D   L  +     +  +G  PQV    ++G       P 
Sbjct: 466 VQVGKQ--EEDSRSSSEESDSDREAL-AAMNAAQVKPLGKSPQVKPASTMG-----MGPL 517

Query: 263 DTGSGPGEPGGSGAGCASG-----------TEKFGYLPATGDGPQPGSPCGPVGFPVPSG 311
             G+GP  PG  G    S            + +     + G+ P   +P           
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577

Query: 312 GESLSSAAQAPPQSAA-LCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQP 370
            +  SS A+ PPQ A  + +   A+   +  E+       +D  +APA       A+A+P
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAKP 634

Query: 371 ASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPV 430
           A +    +      +T AS++     + +    +A  A S        + GT+       
Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP----- 689

Query: 431 PCAQDRGTDRSSDNSHQDRP------EEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVI-- 482
             A+D  +   SD+  +         +  S G   +++   +P  VK     G+ PV+  
Sbjct: 690 --AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP--VKGSLGQGTAPVLPG 745

Query: 483 QLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQ-RLRRKKRPMVQGPAGCQVFQPSPS 541
           +    ++  +A  Q   +    E   E ++ SPAQ +   KK      PA  +   PS  
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--PSAK 803

Query: 542 GGTAG--------------DPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSL 587
           G  +                P  +  P   P++ ++    P+S P+  ++    A+  + 
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863

Query: 588 PEQPEDSAQLQQE 600
           PE+   S++ + +
Sbjct: 864 PEEDSGSSEEESD 876



 Score = 36.6 bits (83), Expect = 0.15
 Identities = 103/479 (21%), Positives = 167/479 (34%), Gaps = 77/479 (16%)

Query: 45   ASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQL 104
            A S P V  G++R  P +++    SS  + + E + G    LAV   +   +  GL ++ 
Sbjct: 676  AGSSPAVAGGTQR--PAEDS---SSSEESDSEEEKTG----LAVTVGQAKSVGKGLQVKA 726

Query: 105  PSVPTQGR-------------ALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRE 151
             SVP +G                T  +++    +  + S        +A  P +     +
Sbjct: 727  ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 152  RLAGVEEVSCLRPREARDGGMSSPG--------CDRRSPTLSKEEPPGRP------LTSS 197
            +       +  R   A+ G +S+PG          +RSP  SK +PP R       L   
Sbjct: 787  KTQAKANPAAARAPSAK-GTISAPGKVVTAAAQAKQRSP--SKVKPPVRNPQNSTVLARG 843

Query: 198  PDPVPVRVRKKWRRQGAHSECEEGAGDFLW-LDQSPRGDNLLSVGDPPQVADLESLGGPC 256
            P  VP   +       A +  EE +G      D     + L  V    +   + +   P 
Sbjct: 844  PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 257  RPPSPKDTGSGPGEPGGSGAGCASG------------TEKFGYLPATGDGPQPGSPCGPV 304
            +    K  G+ P  PG +G   A              ++  G  PA     Q   P  P+
Sbjct: 904  KESPRK--GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP--PL 959

Query: 305  GFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQD---- 360
             F  P+   +  +A  A  Q+A+    A A  S  +  +        DE   PA      
Sbjct: 960  IFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSS----SESEDEDVIPATQCLTP 1015

Query: 361  QEELEAKAQPASRGRL--EQGLAAPADTCASSREPLGGLSSSLDTEASRA-----CSGPF 413
                     P +  R+  +  +A  + +  SSR   G       T+   A      + P 
Sbjct: 1016 GIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQ 1075

Query: 414  MEQRRSKGTKNLKKGPVP-CAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVK 471
                ++KGT  L+K  +P   Q      SSD+S     E+ S       E+ + P G K
Sbjct: 1076 STSVQAKGTNKLRKPKLPEVQQATKAPESSDDS-----EDSSDSSSGSEEDGEGPQGAK 1129



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 96/466 (20%), Positives = 160/466 (34%), Gaps = 67/466 (14%)

Query: 174 SPGCDRRSPTLSKEEPPGRPLTSSPDPV-PVRVRKKWRRQGAHSECEEGAGDFLWLDQSP 232
           +P  ++    + + +P   P    P    PV V+ K  +   +SE  E + D    +++P
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624

Query: 233 RGDNLLSVGDPPQVADLESLG-----------GPCR--PPSPKDTGSGPGEPGGSGAGCA 279
                       ++   ++              P R    +P+  G+    P GS    A
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS-PAGSSPAVA 683

Query: 280 SGTEKFGYLPA--TGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPPQSAALCLGA 332
            GT++    PA  +    +  S     G  V  G     G+ L   A + P   +L  G 
Sbjct: 684 GGTQR----PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 333 SAQASAEQQEAVCVVRTGSDEGQAPAQDQEELE-AKAQPA---SRGRLEQGLAAPADTCA 388
           +     +    V  V+    E    ++++ + E A A PA   +  +  Q  A PA   A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 389 SSREPLGGLSSSLDTEAS----RACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDN 444
            S +        + T A+    R+ S      R  + +  L +GP       G   ++  
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS-VPSVGKAVATAA 858

Query: 445 SHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVL 504
             Q  PEE S  G    E         L     SG   Q+  A++        P K    
Sbjct: 859 QAQTGPEEDS--GSSEEESDSEEEAETLAQVKPSGKTHQIRAALA--------PAK---- 904

Query: 505 EDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGS-- 562
           E   + ++P+P         P   GP+  Q  +   SG ++ +    SD   P    S  
Sbjct: 905 ESPRKGAAPTP---------PGKTGPSAAQAGKQDDSGSSSEESD--SDGEAPAAVTSAQ 953

Query: 563 -----LALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
                L   DP+  PA   + P +A+  S P +   S    +   S
Sbjct: 954 VIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSS 999


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 122/613 (19%), Positives = 218/613 (35%), Gaps = 82/613 (13%)

Query: 32  ASSMPGLSPDGPGASSGPGVRAG---SRRKIPR-KEALRGGSSRAAGAAEVRPGVLELLA 87
           A+S P     G GA+  P  +AG   S+ K  + +E     S  ++ + E  P    LL 
Sbjct: 302 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 361

Query: 88  VVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERAL 147
              S  +             P +G A                + P    +++    E + 
Sbjct: 362 AKASGKTSQVGAASAPAKESPRKGAAPAPP----------GKTGPAVAKAQAGKREEDSQ 411

Query: 148 ACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEP-----PGRPLTSSPDPVP 202
           +  E     EE     P +A+  G +       +P  +KE P     P  P  + P    
Sbjct: 412 SSSEESDSEEEA----PAQAKPSGKAPQVRAASAP--AKESPRKGAAPAPPRKTGPAAAQ 465

Query: 203 VRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPK 262
           V+V K+   + + S  EE   D   L  +     +  +G  PQV    ++G       P 
Sbjct: 466 VQVGKQ--EEDSRSSSEESDSDREAL-AAMNAAQVKPLGKSPQVKPASTMG-----MGPL 517

Query: 263 DTGSGPGEPGGSGAGCASG-----------TEKFGYLPATGDGPQPGSPCGPVGFPVPSG 311
             G+GP  PG  G    S            + +     + G+ P   +P           
Sbjct: 518 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 577

Query: 312 GESLSSAAQAPPQSAA-LCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQP 370
            +  SS A+ PPQ A  + +   A+   +  E+       +D  +APA       A+A+P
Sbjct: 578 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAKP 634

Query: 371 ASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPV 430
           A +    +      +T AS++     + +    +A  A S        + GT+       
Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP----- 689

Query: 431 PCAQDRGTDRSSDNSHQDRP------EEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVI-- 482
             A+D  +   SD+  +         +  S G   +++   +P  VK     G+ PV+  
Sbjct: 690 --AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP--VKGSLGQGTAPVLPG 745

Query: 483 QLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQ-RLRRKKRPMVQGPAGCQVFQPSPS 541
           +    ++  +A  Q   +    E   E ++ SPAQ +   KK      PA  +   PS  
Sbjct: 746 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--PSAK 803

Query: 542 GGTAG--------------DPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSL 587
           G  +                P  +  P   P++ ++    P+S P+  ++    A+  + 
Sbjct: 804 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 863

Query: 588 PEQPEDSAQLQQE 600
           PE+   S++ + +
Sbjct: 864 PEEDSGSSEEESD 876



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 108/525 (20%), Positives = 181/525 (34%), Gaps = 113/525 (21%)

Query: 45   ASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQL 104
            A S P V  G++R  P +++    SS  + + E + G    LAV   +   +  GL ++ 
Sbjct: 676  AGSSPAVAGGTQR--PAEDS---SSSEESDSEEEKTG----LAVTVGQAKSVGKGLQVKA 726

Query: 105  PSVPTQGR-------------ALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRE 151
             SVP +G                T  +++    +  + S        +A  P +     +
Sbjct: 727  ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 786

Query: 152  RLAGVEEVSCLRPREARDGGMSSPG--------CDRRSPTLSKEEPPGRP------LTSS 197
            +       +  R   A+ G +S+PG          +RSP  SK +PP R       L   
Sbjct: 787  KTQAKANPAAARAPSAK-GTISAPGKVVTAAAQAKQRSP--SKVKPPVRNPQNSTVLARG 843

Query: 198  PDPVPVRVRKKWRRQGAHSECEEGAGDFLW-LDQSPRGDNLLSVGDPPQVADLESLGGPC 256
            P  VP   +       A +  EE +G      D     + L  V    +   + +   P 
Sbjct: 844  PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903

Query: 257  RPPSPKDTGSGPGEPGGSGAGCASG------------TEKFGYLPATGDGPQP------- 297
            +    K  G+ P  PG +G   A              ++  G  PA     Q        
Sbjct: 904  KESPRK--GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 961

Query: 298  ----GSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAV----CV--- 346
                 SP GP   P  +   S    A+A   +A      S+ + +E ++ +    C+   
Sbjct: 962  VDPNRSPAGPAATPAQAQAASTPRKARASESTAR-----SSSSESEDEDVIPATQCLTPG 1016

Query: 347  VRTG---------------SDEGQAPAQDQEELE------------AKAQPASRGRLEQG 379
            +RT                S  G + +++   +             +K  PAS    +  
Sbjct: 1017 IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAA 1076

Query: 380  LAAPADTCASSREPLGGL--SSSLDTEASRA-CSGPFMEQRRSKGTKNLKKGPVP-CAQD 435
            L   A   + ++ P+     SS +D+       + P     ++KGT  L+K  +P   Q 
Sbjct: 1077 LKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1136

Query: 436  RGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP 480
                 SSD+S     E+ S       E+ + P G K    LG  P
Sbjct: 1137 TKAPESSDDS-----EDSSDSSSGSEEDGEGPQGAKSAHTLGPTP 1176



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 96/466 (20%), Positives = 160/466 (34%), Gaps = 67/466 (14%)

Query: 174 SPGCDRRSPTLSKEEPPGRPLTSSPDPV-PVRVRKKWRRQGAHSECEEGAGDFLWLDQSP 232
           +P  ++    + + +P   P    P    PV V+ K  +   +SE  E + D    +++P
Sbjct: 565 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 624

Query: 233 RGDNLLSVGDPPQVADLESLG-----------GPCR--PPSPKDTGSGPGEPGGSGAGCA 279
                       ++   ++              P R    +P+  G+    P GS    A
Sbjct: 625 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS-PAGSSPAVA 683

Query: 280 SGTEKFGYLPA--TGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPPQSAALCLGA 332
            GT++    PA  +    +  S     G  V  G     G+ L   A + P   +L  G 
Sbjct: 684 GGTQR----PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 739

Query: 333 SAQASAEQQEAVCVVRTGSDEGQAPAQDQEELE-AKAQPA---SRGRLEQGLAAPADTCA 388
           +     +    V  V+    E    ++++ + E A A PA   +  +  Q  A PA   A
Sbjct: 740 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 799

Query: 389 SSREPLGGLSSSLDTEAS----RACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDN 444
            S +        + T A+    R+ S      R  + +  L +GP       G   ++  
Sbjct: 800 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS-VPSVGKAVATAA 858

Query: 445 SHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVL 504
             Q  PEE S  G    E         L     SG   Q+  A++        P K    
Sbjct: 859 QAQTGPEEDS--GSSEEESDSEEEAETLAQVKPSGKTHQIRAALA--------PAK---- 904

Query: 505 EDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGS-- 562
           E   + ++P+P         P   GP+  Q  +   SG ++ +    SD   P    S  
Sbjct: 905 ESPRKGAAPTP---------PGKTGPSAAQAGKQDDSGSSSEESD--SDGEAPAAVTSAQ 953

Query: 563 -----LALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
                L   DP+  PA   + P +A+  S P +   S    +   S
Sbjct: 954 VIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSS 999


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
           [Homo sapiens]
          Length = 1411

 Score = 43.9 bits (102), Expect = 0.001
 Identities = 122/613 (19%), Positives = 218/613 (35%), Gaps = 82/613 (13%)

Query: 32  ASSMPGLSPDGPGASSGPGVRAG---SRRKIPR-KEALRGGSSRAAGAAEVRPGVLELLA 87
           A+S P     G GA+  P  +AG   S+ K  + +E     S  ++ + E  P    LL 
Sbjct: 225 AASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQ 284

Query: 88  VVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERAL 147
              S  +             P +G A                + P    +++    E + 
Sbjct: 285 AKASGKTSQVGAASAPAKESPRKGAAPAPP----------GKTGPAVAKAQAGKREEDSQ 334

Query: 148 ACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEP-----PGRPLTSSPDPVP 202
           +  E     EE     P +A+  G +       +P  +KE P     P  P  + P    
Sbjct: 335 SSSEESDSEEEA----PAQAKPSGKAPQVRAASAP--AKESPRKGAAPAPPRKTGPAAAQ 388

Query: 203 VRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPK 262
           V+V K+   + + S  EE   D   L  +     +  +G  PQV    ++G       P 
Sbjct: 389 VQVGKQ--EEDSRSSSEESDSDREAL-AAMNAAQVKPLGKSPQVKPASTMG-----MGPL 440

Query: 263 DTGSGPGEPGGSGAGCASG-----------TEKFGYLPATGDGPQPGSPCGPVGFPVPSG 311
             G+GP  PG  G    S            + +     + G+ P   +P           
Sbjct: 441 GKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQ 500

Query: 312 GESLSSAAQAPPQSAA-LCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQP 370
            +  SS A+ PPQ A  + +   A+   +  E+       +D  +APA       A+A+P
Sbjct: 501 AKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAA---MTAAQAKP 557

Query: 371 ASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPV 430
           A +    +      +T AS++     + +    +A  A S        + GT+       
Sbjct: 558 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRP----- 612

Query: 431 PCAQDRGTDRSSDNSHQDRP------EEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVI-- 482
             A+D  +   SD+  +         +  S G   +++   +P  VK     G+ PV+  
Sbjct: 613 --AEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP--VKGSLGQGTAPVLPG 668

Query: 483 QLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQ-RLRRKKRPMVQGPAGCQVFQPSPS 541
           +    ++  +A  Q   +    E   E ++ SPAQ +   KK      PA  +   PS  
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--PSAK 726

Query: 542 GGTAG--------------DPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSL 587
           G  +                P  +  P   P++ ++    P+S P+  ++    A+  + 
Sbjct: 727 GTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTG 786

Query: 588 PEQPEDSAQLQQE 600
           PE+   S++ + +
Sbjct: 787 PEEDSGSSEEESD 799



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 108/525 (20%), Positives = 181/525 (34%), Gaps = 113/525 (21%)

Query: 45   ASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQL 104
            A S P V  G++R  P +++    SS  + + E + G    LAV   +   +  GL ++ 
Sbjct: 599  AGSSPAVAGGTQR--PAEDS---SSSEESDSEEEKTG----LAVTVGQAKSVGKGLQVKA 649

Query: 105  PSVPTQGR-------------ALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRE 151
             SVP +G                T  +++    +  + S        +A  P +     +
Sbjct: 650  ASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVK 709

Query: 152  RLAGVEEVSCLRPREARDGGMSSPG--------CDRRSPTLSKEEPPGRP------LTSS 197
            +       +  R   A+ G +S+PG          +RSP  SK +PP R       L   
Sbjct: 710  KTQAKANPAAARAPSAK-GTISAPGKVVTAAAQAKQRSP--SKVKPPVRNPQNSTVLARG 766

Query: 198  PDPVPVRVRKKWRRQGAHSECEEGAGDFLW-LDQSPRGDNLLSVGDPPQVADLESLGGPC 256
            P  VP   +       A +  EE +G      D     + L  V    +   + +   P 
Sbjct: 767  PASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 826

Query: 257  RPPSPKDTGSGPGEPGGSGAGCASG------------TEKFGYLPATGDGPQP------- 297
            +    K  G+ P  PG +G   A              ++  G  PA     Q        
Sbjct: 827  KESPRK--GAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 884

Query: 298  ----GSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAV----CV--- 346
                 SP GP   P  +   S    A+A   +A      S+ + +E ++ +    C+   
Sbjct: 885  VDPNRSPAGPAATPAQAQAASTPRKARASESTAR-----SSSSESEDEDVIPATQCLTPG 939

Query: 347  VRTG---------------SDEGQAPAQDQEELE------------AKAQPASRGRLEQG 379
            +RT                S  G + +++   +             +K  PAS    +  
Sbjct: 940  IRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAA 999

Query: 380  LAAPADTCASSREPLGGL--SSSLDTEASRA-CSGPFMEQRRSKGTKNLKKGPVP-CAQD 435
            L   A   + ++ P+     SS +D+       + P     ++KGT  L+K  +P   Q 
Sbjct: 1000 LKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA 1059

Query: 436  RGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGP 480
                 SSD+S     E+ S       E+ + P G K    LG  P
Sbjct: 1060 TKAPESSDDS-----EDSSDSSSGSEEDGEGPQGAKSAHTLGPTP 1099



 Score = 30.8 bits (68), Expect = 8.2
 Identities = 96/466 (20%), Positives = 160/466 (34%), Gaps = 67/466 (14%)

Query: 174 SPGCDRRSPTLSKEEPPGRPLTSSPDPV-PVRVRKKWRRQGAHSECEEGAGDFLWLDQSP 232
           +P  ++    + + +P   P    P    PV V+ K  +   +SE  E + D    +++P
Sbjct: 488 APAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAP 547

Query: 233 RGDNLLSVGDPPQVADLESLG-----------GPCR--PPSPKDTGSGPGEPGGSGAGCA 279
                       ++   ++              P R    +P+  G+    P GS    A
Sbjct: 548 AAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATS-PAGSSPAVA 606

Query: 280 SGTEKFGYLPA--TGDGPQPGSPCGPVGFPVPSG-----GESLSSAAQAPPQSAALCLGA 332
            GT++    PA  +    +  S     G  V  G     G+ L   A + P   +L  G 
Sbjct: 607 GGTQR----PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGT 662

Query: 333 SAQASAEQQEAVCVVRTGSDEGQAPAQDQEELE-AKAQPA---SRGRLEQGLAAPADTCA 388
           +     +    V  V+    E    ++++ + E A A PA   +  +  Q  A PA   A
Sbjct: 663 APVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA 722

Query: 389 SSREPLGGLSSSLDTEAS----RACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDN 444
            S +        + T A+    R+ S      R  + +  L +GP       G   ++  
Sbjct: 723 PSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS-VPSVGKAVATAA 781

Query: 445 SHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVL 504
             Q  PEE S  G    E         L     SG   Q+  A++        P K    
Sbjct: 782 QAQTGPEEDS--GSSEEESDSEEEAETLAQVKPSGKTHQIRAALA--------PAK---- 827

Query: 505 EDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGS-- 562
           E   + ++P+P         P   GP+  Q  +   SG ++ +    SD   P    S  
Sbjct: 828 ESPRKGAAPTP---------PGKTGPSAAQAGKQDDSGSSSEESD--SDGEAPAAVTSAQ 876

Query: 563 -----LALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPS 603
                L   DP+  PA   + P +A+  S P +   S    +   S
Sbjct: 877 VIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSS 922


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,243,012
Number of Sequences: 37866
Number of extensions: 4052165
Number of successful extensions: 19373
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 15905
Number of HSP's gapped (non-prelim): 3886
length of query: 1216
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1102
effective length of database: 13,930,794
effective search space: 15351734988
effective search space used: 15351734988
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.