Search of human proteins with 46519154

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
         (627 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...  1231   0.0  
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...  1201   0.0  
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...  1167   0.0  
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                   1167   0.0  
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   917   0.0  
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   917   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   197   2e-50
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        185   1e-46
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       182   1e-45
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        182   1e-45
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        182   1e-45
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        182   1e-45
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        182   1e-45
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       173   5e-43
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        172   8e-43
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        172   8e-43
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   169   5e-42
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   167   4e-41
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   167   4e-41
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    158   1e-38
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   154   2e-37
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   148   1e-35
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...   148   2e-35
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  146   5e-35
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   143   4e-34
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   142   7e-34
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   142   7e-34
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   142   7e-34
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   140   4e-33
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          127   2e-29

>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score = 1231 bits (3184), Expect = 0.0
 Identities = 627/627 (100%), Positives = 627/627 (100%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600

Query: 601 KTILEGIDPAKHQVRVAFDACKLLRKE 627
           KTILEGIDPAKHQVRVAFDACKLLRKE
Sbjct: 601 KTILEGIDPAKHQVRVAFDACKLLRKE 627


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score = 1201 bits (3107), Expect = 0.0
 Identities = 616/627 (98%), Positives = 616/627 (98%), Gaps = 11/627 (1%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAA           AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM
Sbjct: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 589

Query: 601 KTILEGIDPAKHQVRVAFDACKLLRKE 627
           KTILEGIDPAKHQVRVAFDACKLLRKE
Sbjct: 590 KTILEGIDPAKHQVRVAFDACKLLRKE 616


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score = 1167 bits (3020), Expect = 0.0
 Identities = 601/619 (97%), Positives = 604/619 (97%), Gaps = 1/619 (0%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 599
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 600 MKTILEGIDPAKHQVRVAF 618
            +T L     A H   V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619



 Score =  248 bits (632), Expect = 2e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637

Query: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 564 TTAT 567
              T
Sbjct: 697 VPTT 700



 Score =  201 bits (512), Expect = 1e-51
 Identities = 143/446 (32%), Positives = 233/446 (52%), Gaps = 18/446 (4%)

Query: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998

Query: 149  LLEAAGI----GKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            L+ A       G  S++       PE   + TS+V+    ++   +      ++H     
Sbjct: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA---SQSMPPVYPSVDIDAHTESNH 1055

Query: 205  DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
            DT +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++
Sbjct: 1056 DT-ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDI 1114

Query: 265  EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            E +  +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 325  LNEGANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
            LN GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234

Query: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFES 440
            G  ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294

Query: 441  PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
             LT+AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A 
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA- 1353

Query: 501  TEETQETALTLACCGGFSEVADFLIK 526
             +  + T L  A   G  +V  +L+K
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 295  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 355  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 415  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 471
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 472  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 532  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 587  LLQAGADLDKQEDMK 601
            L+QAGAD+D  ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358



 Score =  167 bits (423), Expect = 3e-41
 Identities = 99/248 (39%), Positives = 136/248 (54%), Gaps = 5/248 (2%)

Query: 180 SCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG- 238
           +C      AAL   +  N           L EA  +G    V  LL +G ++N  TEE  
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298
           E+ L LAC  G+ E+A  L+   A++E     G  TPLM AS  G+L++VK LL   A+V
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIE----LGCSTPLMEASQEGHLELVKYLLASGANV 561

Query: 299 NSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL 358
           ++ +ATG+TALTYAC  G  D+  VLL  GA++E  +E G TPLM+AA AGH+   + L+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621

Query: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
             GA +N  +     + ++LAC  GHL +V  LL  GAD  H+  +  T L+EA   GH 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 419 EVARLLLD 426
            V   LLD
Sbjct: 682 NVVSYLLD 689



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 5/205 (2%)

Query: 130 AEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
           A+GA++     ETQ     L    G  +++    KA AD E+    ++ +  A  E    
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLE 549

Query: 190 LTRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246
           L +       N H        +L  AC +G  +    LL  G  +   +E G + L  A 
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609

Query: 247 SAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
            AG+    Q L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669

Query: 307 TALTYACAGGFVDIVKVLLNEGANI 331
           T L  A  GG  ++V  LL+   N+
Sbjct: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 1167 bits (3020), Expect = 0.0
 Identities = 601/619 (97%), Positives = 604/619 (97%), Gaps = 1/619 (0%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 599
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 600 MKTILEGIDPAKHQVRVAF 618
            +T L     A H   V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619



 Score =  248 bits (632), Expect = 2e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637

Query: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696

Query: 564 TTAT 567
              T
Sbjct: 697 VPTT 700



 Score =  201 bits (512), Expect = 1e-51
 Identities = 143/446 (32%), Positives = 233/446 (52%), Gaps = 18/446 (4%)

Query: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998

Query: 149  LLEAAGI----GKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            L+ A       G  S++       PE   + TS+V+    ++   +      ++H     
Sbjct: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA---SQSMPPVYPSVDIDAHTESNH 1055

Query: 205  DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
            DT +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++
Sbjct: 1056 DT-ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDI 1114

Query: 265  EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            E +  +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+L
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174

Query: 325  LNEGANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
            LN GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234

Query: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFES 440
            G  ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++
Sbjct: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294

Query: 441  PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
             LT+AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A 
Sbjct: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA- 1353

Query: 501  TEETQETALTLACCGGFSEVADFLIK 526
             +  + T L  A   G  +V  +L+K
Sbjct: 1354 ADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score =  191 bits (486), Expect = 1e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 295  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 355  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 415  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 471
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 472  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 532  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 587  LLQAGADLDKQEDMK 601
            L+QAGAD+D  ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358



 Score =  167 bits (423), Expect = 3e-41
 Identities = 99/248 (39%), Positives = 136/248 (54%), Gaps = 5/248 (2%)

Query: 180 SCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG- 238
           +C      AAL   +  N           L EA  +G    V  LL +G ++N  TEE  
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505

Query: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298
           E+ L LAC  G+ E+A  L+   A++E     G  TPLM AS  G+L++VK LL   A+V
Sbjct: 506 ETALTLACCGGFSEVADFLIKAGADIE----LGCSTPLMEASQEGHLELVKYLLASGANV 561

Query: 299 NSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL 358
           ++ +ATG+TALTYAC  G  D+  VLL  GA++E  +E G TPLM+AA AGH+   + L+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621

Query: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
             GA +N  +     + ++LAC  GHL +V  LL  GAD  H+  +  T L+EA   GH 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 419 EVARLLLD 426
            V   LLD
Sbjct: 682 NVVSYLLD 689



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 5/205 (2%)

Query: 130 AEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
           A+GA++     ETQ     L    G  +++    KA AD E+    ++ +  A  E    
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLE 549

Query: 190 LTRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246
           L +       N H        +L  AC +G  +    LL  G  +   +E G + L  A 
Sbjct: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609

Query: 247 SAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
            AG+    Q L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+
Sbjct: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669

Query: 307 TALTYACAGGFVDIVKVLLNEGANI 331
           T L  A  GG  ++V  LL+   N+
Sbjct: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  917 bits (2370), Expect = 0.0
 Identities = 479/586 (81%), Positives = 516/586 (88%), Gaps = 24/586 (4%)

Query: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 574 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 618
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648



 Score =  246 bits (628), Expect = 5e-65
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666

Query: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725

Query: 564 TTATGDTALT 573
                 T LT
Sbjct: 726 APPPDVTQLT 735



 Score =  207 bits (526), Expect = 3e-53
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205

Query: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265

Query: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
                                             TPLM A ++GH+++V+YL+
Sbjct: 1386 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1406



 Score =  198 bits (503), Expect = 1e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133

Query: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

Query: 416  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253

Query: 473  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 533  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 588  LQAGADLDKQEDMK 601
            +QAGAD+D  ++ K
Sbjct: 1373 VQAGADVDAADNRK 1386



 Score =  173 bits (439), Expect = 4e-43
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 274  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 334  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 393  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 449
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263

Query: 450  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 508
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323

Query: 509  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383

Query: 566  ATGDTALTYACENGHTDVADVLLQ 589
                T L  A   GH  V   L++
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLVK 1407



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 60/204 (29%), Positives = 87/204 (42%), Gaps = 5/204 (2%)

Query: 131 EGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAAL 190
           +GA++     ETQ    AL  A   G L  AD    A  ++    ++ +  A  E    L
Sbjct: 522 QGANINAQTEETQET--ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLEL 579

Query: 191 TRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
            +       N H        +L  AC +G  +    LL  G  +   +E G + L  A  
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 248 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNT 307
           AG+    Q L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 308 ALTYACAGGFVDIVKVLLNEGANI 331
            L  A  GG   +V  LL+   N+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNL 723


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  917 bits (2370), Expect = 0.0
 Identities = 479/586 (81%), Positives = 516/586 (88%), Gaps = 24/586 (4%)

Query: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 574 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 618
           YACENGHTDVADVLLQAGADL+ + E  +T L     A H   V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648



 Score =  246 bits (628), Expect = 5e-65
 Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
           L EA S G V   R LL+ G  +N H+ E  ES L LAC  G+ E+ + LL   A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GA++E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
             FL++AGAD E       T LMEA  +GH+E+ + LL +GA V+    + ++ LT A  
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666

Query: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
            L+LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725

Query: 564 TTATGDTALT 573
                 T LT
Sbjct: 726 APPPDVTQLT 735



 Score =  207 bits (526), Expect = 3e-53
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954

Query: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014

Query: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
                                             TPLM A ++GH+++V+YL+
Sbjct: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155



 Score =  198 bits (503), Expect = 1e-50
 Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)

Query: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882

Query: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942

Query: 416  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002

Query: 473  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 533  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121

Query: 588  LQAGADLDKQEDMK 601
            +QAGAD+D  ++ K
Sbjct: 1122 VQAGADVDAADNRK 1135



 Score =  173 bits (439), Expect = 4e-43
 Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)

Query: 274  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
            T L  A +GG+ ++V+ LL   A +  +   G T L  A   G V +V++LL+ GA+IE 
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 334  HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
             +E    TPL  A S G  EV  +LL  GA    H N    + L+LA   G++++++ LL
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 952

Query: 393  EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 449
             AGA+   +T      + LM A M+GH    +LLLD G+ +N   + +  + LTLA   G
Sbjct: 953  NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012

Query: 450  HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 508
              E+ +LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TA
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072

Query: 509  LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 565
            LT+A   G  +  + LI  GA I++     +TPL  A+  GHL++V+ L+ +GA+V A  
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132

Query: 566  ATGDTALTYACENGHTDVADVLLQ 589
                T L  A   GH  V   L++
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLVK 1156



 Score =  147 bits (372), Expect = 2e-35
 Identities = 132/437 (30%), Positives = 184/437 (42%), Gaps = 90/437 (20%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAMHANVEDR 267
           L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+   A++E  
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIE-- 561

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
              G  TPLM A+  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+  VLL  
Sbjct: 562 --LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQA 619

Query: 328 GANIEDHNENGHTPLMEAASAGHV----------------------------------EV 353
           GA++E  +E G TPLM+AA AGHV                                   V
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679

Query: 354 ARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC 413
             +LL HGA   TH  +   + L  A   GH  +V +LL+   +         T L    
Sbjct: 680 VELLLAHGAD-PTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPS 738

Query: 414 MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
            D +    R+ + +   V  P +  + P  +A          L I   A     +    T
Sbjct: 739 HDLN-RAPRVPVQALPMVVPPQEPDKPPANVAT--------TLPIRNKAVSGRASAMSNT 789

Query: 474 PLMEAAREGHEEMVA-----------LLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
           P    A    +               L +    +I+AQTE   +TALTLAC GG      
Sbjct: 790 PTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGG------ 843

Query: 523 FLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTD 582
                                   H ELV+ LL  GA++      G T L  A   GH  
Sbjct: 844 ------------------------HEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG 879

Query: 583 VADVLLQAGADLDKQED 599
           V ++LL  GAD++ Q +
Sbjct: 880 VVEILLDNGADIEAQSE 896



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 60/204 (29%), Positives = 87/204 (42%), Gaps = 5/204 (2%)

Query: 131 EGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAAL 190
           +GA++     ETQ    AL  A   G L  AD    A  ++    ++ +  A  E    L
Sbjct: 522 QGANINAQTEETQET--ALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLEL 579

Query: 191 TRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACS 247
            +       N H        +L  AC +G  +    LL  G  +   +E G + L  A  
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639

Query: 248 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNT 307
           AG+    Q L++  ANV       D T L  A +GG+L +V+LLL H AD   +   G+T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699

Query: 308 ALTYACAGGFVDIVKVLLNEGANI 331
            L  A  GG   +V  LL+   N+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNL 723


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  197 bits (502), Expect = 2e-50
 Identities = 144/435 (33%), Positives = 224/435 (51%), Gaps = 14/435 (3%)

Query: 167  ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTR---SLAEAC---SDGDVNA 220
            AD E    L ++      E    L    AE +H    VD R   S+A  C   S G  + 
Sbjct: 673  ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHE--DVDGRTALSVAALCVPASKGHASV 730

Query: 221  VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
            V  L+D G  V+   ++G + L +A   G+ ++  +LL   A+V+   N G  TPL+AA+
Sbjct: 731  VSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR-TPLLAAA 789

Query: 281  SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
            S G+  +V  LL   A V+S  + G T L+ A A G V++V+ LL+ G +    ++ G T
Sbjct: 790  SMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWT 849

Query: 341  PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
            PL  AA  GH  +   L++ GA  N   N+ +   + LA  +GH D V+ LLE  ++ + 
Sbjct: 850  PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFI-LASQEGHYDCVQILLENKSNIDQ 908

Query: 401  KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
            +  +   AL  A ++GH ++  LL   GA VN         L + A    + +A   +E 
Sbjct: 909  RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968

Query: 461  GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            GAN+E  + EG T L  +  +GH EMV +L+A  A++NA   E + +AL  A   G  +V
Sbjct: 969  GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNE-KRSALQSAAWQGHVKV 1027

Query: 521  ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
               LI+ GA ++  C+   T L  A+QEGH+++V+ LL  GA+ +     G TA+  A +
Sbjct: 1028 VQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAK 1087

Query: 578  NGHTDVADVLLQAGA 592
            NGH+ +  +L + GA
Sbjct: 1088 NGHSQIIKLLEKYGA 1102



 Score =  196 bits (498), Expect = 5e-50
 Identities = 133/434 (30%), Positives = 211/434 (48%), Gaps = 41/434 (9%)

Query: 200  NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
            +    D+R+   A +  G  + V  LL  G  VN+   EG + L  A   G+ E+ + LL
Sbjct: 638  DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697

Query: 259  AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
               A V      G     +  L   +S G+  +V LL+   A+V+     G T L  A  
Sbjct: 698  DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757

Query: 315  GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
             G VD+V +LL  GA+++  + NG TPL+ AAS GH  V   LL  GA +++  +E + +
Sbjct: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816

Query: 375  ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 434
             L++A  +G++++VR LL+ G D+ H+ D   T L  A  +GH  +   L++ GA+ N  
Sbjct: 817  VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876

Query: 435  ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
             +    P  LA+  GH +   +L+E  +N+++   +G   L  AA EGH ++V LL + G
Sbjct: 877  DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936

Query: 495  ANINAQTEETQ--------------------------------ETALTLACCGGFSEVAD 522
            A++N +  + +                                 TAL ++C  G  E+  
Sbjct: 937  ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996

Query: 523  FLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
             LI   AD+    +   + L  A+ +GH+++V+ L+  GA V  T   G TAL  A + G
Sbjct: 997  VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056

Query: 580  HTDVADVLLQAGAD 593
            H DV  VLL+ GAD
Sbjct: 1057 HIDVVQVLLEHGAD 1070



 Score =  194 bits (494), Expect = 2e-49
 Identities = 137/418 (32%), Positives = 207/418 (49%), Gaps = 44/418 (10%)

Query: 219 NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278
           +++R LLD G SVN+    G +LL  A  +G  ++  +L++  A++E     G  TPL  
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584

Query: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
           A+  G+  +V  L+   A++N     G TAL  A  GG  ++V  LL  G  ++  + + 
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644

Query: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
            T L  AA  GH ++   LL HGA +N   NE + +AL  A Y GH ++V  LL+ GA+ 
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703

Query: 399 EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
            H+  +  TAL  A +      GH  V  LL+D GA+V+       +PL +AA  GHV++
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
             LL+E GA+++  ++ G TPL+ AA  GH  +V  LL  GA +++   E + T L++A 
Sbjct: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822

Query: 514 CGGFSEVADFLIKAGAD---------------------------IELGCST--------- 537
             G  EV   L+  G D                           IE G  T         
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           P + ASQEGH + V+ LL + +N+      G  AL  A   GH D+ ++L   GAD++
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940



 Score =  192 bits (488), Expect = 8e-49
 Identities = 140/434 (32%), Positives = 210/434 (48%), Gaps = 44/434 (10%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
            L  A   G    V  L+  G ++N   ++G + L  A   G+ E+   LL     V D  
Sbjct: 582  LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV-DCA 640

Query: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
            +    T L AA+ GG+ DIV  LL H A+VN     G TAL  A   G  +IV+ LL+ G
Sbjct: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700

Query: 329  ANIEDHNENGHTPLMEAA-----SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
            A +   + +G T L  AA     S GH  V  +L+D GA ++ H ++   + L +A Y+G
Sbjct: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 759

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH-------------------------- 417
            H+D+V  LLE GAD +H  +   T L+ A   GH                          
Sbjct: 760  HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819

Query: 418  -------VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
                   VEV R LLD G   N   D+  +PL +AA  GH  +   LIE+GA   E++++
Sbjct: 820  IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879

Query: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
            G  P + A++EGH + V +LL   +NI+ +  + +  AL +A   G  ++ + L   GAD
Sbjct: 880  GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGAD 938

Query: 531  I---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
            +   +      L   + E  L + +Y L +GANV A+ A G TAL  +C  GH ++  VL
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 588  LQAGADLDKQEDMK 601
            +   AD++  ++ K
Sbjct: 999  IAYHADVNAADNEK 1012



 Score =  168 bits (425), Expect = 2e-41
 Identities = 118/358 (32%), Positives = 184/358 (51%), Gaps = 17/358 (4%)

Query: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608

Query: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668

Query: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728

Query: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787

Query: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D + ++D
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD 845



 Score =  157 bits (397), Expect = 3e-38
 Identities = 109/339 (32%), Positives = 169/339 (49%), Gaps = 12/339 (3%)

Query: 286 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 345
           ++++LL+   A VNS+    +  +  A      D ++ LL+ GA++   + NG T L  A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 346 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 405
           A +G ++V  +L+  GA +    +    + LTLA  +GH  +V  L+  GA+  H   + 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 406 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 465
            TAL  A   GH EV   LL +G +V+       + L  AA GGH ++   L++ GA + 
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 466 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC----GGFSEVA 521
           + ++EG T L+ AA  GH E+V  LL  GA +N +  + +      A C     G + V 
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731

Query: 522 DFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
             LI  GA+++  C     TPL+ A+ EGH+++V  LL  GA+V  T   G T L  A  
Sbjct: 732 SLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790

Query: 578 NGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRV 616
            GH  V + LL  GA +D  +     +  I  A+  V V
Sbjct: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829



 Score =  155 bits (393), Expect = 8e-38
 Identities = 114/364 (31%), Positives = 176/364 (48%), Gaps = 6/364 (1%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
            L  A S G  + V  LL  G +V+    EG ++L +A + G  E+ + LL    +   R 
Sbjct: 785  LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844

Query: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
            + G  TPL  A+  G+  I + L+   A  N     G      A   G  D V++LL   
Sbjct: 845  DAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903

Query: 329  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
            +NI+    +G   L  AA  GH ++  +L  HGA +N    + + +   LA  +  L M 
Sbjct: 904  SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL-ENQLTMA 962

Query: 389  RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
             + LE GA+ E    E  TAL  +C  GH+E+ ++L+   A VN   +   S L  AA  
Sbjct: 963  EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022

Query: 449  GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
            GHV++  LLIE GA ++   ++G T L  AA+EGH ++V +LL  GA+ N   ++   TA
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN-HADQFGRTA 1081

Query: 509  LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS---GANVHATT 565
            + +A   G S++   L K GA    GCS   +   ++  L+ +   + S    +N   +T
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141

Query: 566  ATGD 569
              GD
Sbjct: 1142 GGGD 1145


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  185 bits (469), Expect = 1e-46
 Identities = 132/395 (33%), Positives = 200/395 (50%), Gaps = 12/395 (3%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442

Query: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558
           ++   T L +A   G  EVA+ L++  A  +       TPL  A+   + ++   LL  G
Sbjct: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621

Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
           A+ HA    G T L  A +    D+A  LL+ GAD
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656



 Score =  181 bits (459), Expect = 2e-45
 Identities = 136/427 (31%), Positives = 216/427 (50%), Gaps = 19/427 (4%)

Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365

Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424

Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603

Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722

Query: 594 LDKQEDM 600
           +D Q  M
Sbjct: 723 VDAQTKM 729



 Score =  171 bits (433), Expect = 2e-42
 Identities = 144/462 (31%), Positives = 216/462 (46%), Gaps = 18/462 (3%)

Query: 138 VDPETQARLEALLEAAGIGKLSTA----DGKAFADPEVLRRLTS-SVSCALDEAAAALTR 192
           VD  T   L AL  AA  G    A    D KA  + + L   T   ++C  +        
Sbjct: 360 VDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELL 419

Query: 193 MKAENSHNA-GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 251
           +K   S  A  +     +  A   G VN V +L+  G S N     GE+ L +A  +G  
Sbjct: 420 LKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQA 479

Query: 252 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 311
           E+ + L+   A VE +  K D TPL  ++  G  DIV+ LL   A  N+ + +G T L  
Sbjct: 480 EVVRYLVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL 538

Query: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
           +   G  D+   LL+ GA++    + G TPL  AA  G +EVA +LL   A  +      
Sbjct: 539 SAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG--- 595

Query: 372 KESALTLACYKGHLD---MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
            +S LT      H D   +   LL+ GA         +T L  A     +++A  LL+ G
Sbjct: 596 -KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654

Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
           A  N       + + LAA  GHV++ +LL+ R AN+   N  G TPL  AA+E    +  
Sbjct: 655 ADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAE 714

Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545
           +L+ QGA+++AQT+    T L + C  G  ++ +FL++  A +        TPL +A+Q+
Sbjct: 715 VLVNQGAHVDAQTKMGY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQ 773

Query: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
           GH  ++  LL + A+ +  T  G+TAL  A   G+  V D L
Sbjct: 774 GHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  171 bits (432), Expect = 2e-42
 Identities = 133/426 (31%), Positives = 208/426 (48%), Gaps = 7/426 (1%)

Query: 170 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 229
           + L  L  +  C   + A  L   KA  +  A    T  L  AC    +  +  LL  G 
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT-PLHIACKKNRIKVMELLLKHGA 424

Query: 230 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 289
           S+   TE G + + +A   G+  +   L+   A+      +G+    MAA SG   ++V+
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVR 483

Query: 290 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
            L+   A V +++    T L  +   G  DIV+ LL +GA+      +G+TPL  +A  G
Sbjct: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
           H +VA  LLDHGA ++  + +   + L +A   G L++   LL+  A  +       T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602

Query: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
             A    + +VA LLLD GA  +  A +  +PL +AA    +++A  L+E GA+   V  
Sbjct: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
           +G   +  AA+EGH +MV+LLL + AN+N  + ++  T L LA       VA+ L+  GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721

Query: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
            ++       TPL      G++++V +LL   A V+A T  G T L  A + GHT + +V
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781

Query: 587 LLQAGA 592
           LLQ  A
Sbjct: 782 LLQNNA 787



 Score =  164 bits (415), Expect = 2e-40
 Identities = 119/391 (30%), Positives = 195/391 (49%), Gaps = 6/391 (1%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           +L  A   G     + LLD+  + N     G + L +AC     ++ ++LL   A+++  
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
              G +TP+  A+  G+++IV  L+ H A  N+ +  G TAL  A   G  ++V+ L+ +
Sbjct: 430 TESG-LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GA +E   ++  TPL  +A  G  ++ + LL  GA  N  +     + L L+  +GH D+
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDV 547

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
             FLL+ GA     T +  T L  A   G +EVA LLL   A  +    S  +PL +AA 
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
             + ++A LL+++GA+       GYTPL  AA++   ++   LL  GA+ NA T +    
Sbjct: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI-A 666

Query: 508 ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHAT 564
           ++ LA   G  ++   L+   A++ L      TPL  A+QE  + + + L+  GA+V A 
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726

Query: 565 TATGDTALTYACENGHTDVADVLLQAGADLD 595
           T  G T L   C  G+  + + LLQ  A ++
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757



 Score =  155 bits (393), Expect = 8e-38
 Identities = 125/429 (29%), Positives = 203/429 (47%), Gaps = 36/429 (8%)

Query: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60

Query: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178

Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMH-----------------------------TA 408
           +A  +GH  +V  LLE     + +   +H                             T 
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238

Query: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
           L  A   G++ VA LLL+  A V+  A +  +PL +A+  G+  +  LL++RGA ++   
Sbjct: 239 LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298

Query: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
            +G TPL   AR GHE++V +LL + A I ++T+    + L +A  G        L++  
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL-SPLHMATQGDHLNCVQLLLQHN 357

Query: 529 A---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
               D+     T L  A+  GH ++ K LL   AN +A    G T L  AC+     V +
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417

Query: 586 VLLQAGADL 594
           +LL+ GA +
Sbjct: 418 LLLKHGASI 426



 Score =  138 bits (347), Expect = 2e-32
 Identities = 107/337 (31%), Positives = 168/337 (49%), Gaps = 16/337 (4%)

Query: 266 DRGNKGDITP-LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
           DR  K D     + A+  G+L+     + +  D+N  +  G  AL  A   G V++V  L
Sbjct: 34  DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKG 383
           L   AN++   + G+T L  A+ AG  EV +VL+ +GA +N  S N F  + L +A  + 
Sbjct: 94  LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF--TPLYMAAQEN 151

Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPADSFESP 441
           HL++V+FLL+ GA Q   T++  T L  A   GH +V  LLL  D+  +V +PA      
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------ 205

Query: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
           L +AA     + AALL++   N +  +  G+TPL  AA  G+  +  LLL + A ++  T
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF-T 264

Query: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 558
                T L +A   G + +   L+  GA I+       TPL   ++ GH ++V+ LL   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           A + + T  G + L  A +  H +   +LLQ    +D
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 6/93 (6%)

Query: 509 LTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHAT 564
           L  A  G   +  D+ IK G DI + C+      L  AS+EGH+E+V  LL   ANV A 
Sbjct: 46  LRAARAGHLEKALDY-IKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 565 TATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
           T  G+TAL  A   G  +V  VL+  GA+++ Q
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636

Query: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 671



 Score =  178 bits (451), Expect = 2e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 506

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 741

Query: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800

Query: 569 DTALTYACENGHTDVADVL 587
            T L  A   G+  V DVL
Sbjct: 801 TTPLAIAKRLGYISVTDVL 819



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 85  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 598 EDMKTIL 604
           +D +T L
Sbjct: 501 KDDQTPL 507



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767

Query: 569 DTALTYACENGHTDVADVLLQAGA 592
            + L  A + GHTD+  +LL+ GA
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGA 791



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714

Query: 582 DVADVLLQAGADLD 595
            VADVL++ G  +D
Sbjct: 715 PVADVLIKHGVMVD 728



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 440

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 559

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 678

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738

Query: 573 TYACENGHTDVADVLLQAGADLD 595
             A   G+  +   LLQ  AD++
Sbjct: 739 HVASHYGNIKLVKFLLQHQADVN 761



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431



 Score =  140 bits (354), Expect = 3e-33
 Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 14/336 (4%)

Query: 266 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
           DR  K D  T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  L
Sbjct: 38  DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
           L++   +E   + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + H
Sbjct: 98  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156

Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 442
           L++V+FLLE GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210

Query: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 502
            +AA       AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T 
Sbjct: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269

Query: 503 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 559
           +   T L +A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329

Query: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
            + A T  G + +  A +  H D   +LLQ  A++D
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 2e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 569 DTALTYACENGHTDVADVL 587
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 598 EDMKTIL 604
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 569 DTALTYACENGHTDVADVLLQAGA 592
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLD 595
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 573 TYACENGHTDVADVLLQAGADLD 595
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 569 DTALTYACENGHTDVADVLLQAGADLD 595
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 2e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 569 DTALTYACENGHTDVADVL 587
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 598 EDMKTIL 604
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 569 DTALTYACENGHTDVADVLLQAGA 592
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLD 595
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 573 TYACENGHTDVADVLLQAGADLD 595
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 569 DTALTYACENGHTDVADVLLQAGADLD 595
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 2e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 569 DTALTYACENGHTDVADVL 587
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 598 EDMKTIL 604
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 569 DTALTYACENGHTDVADVLLQAGA 592
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLD 595
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 573 TYACENGHTDVADVLLQAGADLD 595
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 569 DTALTYACENGHTDVADVLLQAGADLD 595
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  182 bits (461), Expect = 1e-45
 Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 609
           T L  A +    +VA  LLQ G   + +      ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638



 Score =  178 bits (451), Expect = 2e-44
 Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G +  V+ LL  G S N    + E+ L +A  AG+ E+A+ LL   A V  +  K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ ++VKLLL ++A+ N  +  G+T L  A   G V+ V  LL + A+     
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
           + G TPL  AA  G V VA +LL+  A    H N   ++ LT   +A +  +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
             G          +T L  A     VEVAR LL  G   N  +    +PL LAA  GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           + ALL+ + AN    N  G TPL   A+EGH  +  +L+  G  ++A T     T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708

Query: 513 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 568
              G  ++  FL++  AD+    +LG S PL +A+Q+GH ++V  LL +GA+ +  ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767

Query: 569 DTALTYACENGHTDVADVL 587
            T L  A   G+  V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786



 Score =  177 bits (450), Expect = 2e-44
 Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 597
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A ++ K 
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 598 EDMKTIL 604
           +D +T L
Sbjct: 468 KDDQTPL 474



 Score =  173 bits (438), Expect = 5e-43
 Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           AC    V  +  LL  G S++  TE G + L +A   G+  + + LL   A+      K 
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           + TPL  A+  G+ ++ K LL + A VN+++    T L  A   G  ++VK+LL   AN 
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
                 GHTPL  AA  GHVE    LL+  A     + +   + L +A   G + +   L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           LE  A          T L  A    ++++ +LLL  G   + PA +  +PL +AA    V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+A  L++ G +    + +G TPL  AA+EGH EMVALLL++ AN N   +    T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
               G   VAD LIK G  ++       TPL  AS  G+++LVK+LL   A+V+A T  G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734

Query: 569 DTALTYACENGHTDVADVLLQAGA 592
            + L  A + GHTD+  +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758



 Score =  170 bits (431), Expect = 3e-42
 Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLD 595
            VADVL++ G  +D
Sbjct: 682 PVADVLIKHGVMVD 695



 Score =  162 bits (409), Expect = 1e-39
 Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G     + LLD+G   N     G + L +AC   +  + ++LL   A++ D   +  +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  AS  G+L IVK LL   A  N  +    T L  A   G  ++ K LL   A +    
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GH  + ++LL++ A  N  +     + L +A  +GH++ V  LLE  
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A Q   T +  T L  A   G V VA LLL+  A  N    +  +PL +A    ++++  
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL+ RG +       GYTPL  AA++   E+   LL  G + NA++ +   T L LA   
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +E+   L+   A+  LG     TPL   +QEGH+ +   L+  G  V ATT  G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705

Query: 573 TYACENGHTDVADVLLQAGADLD 595
             A   G+  +   LLQ  AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728



 Score =  150 bits (380), Expect = 3e-36
 Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398



 Score =  138 bits (347), Expect = 2e-32
 Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           T  + A+  G LD     L +  D+N+ +  G   L  A   G V +V  LL++   +E 
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
             + G+T L  AA AG  EV R L+++GA +N  S +   + L +A  + HL++V+FLLE
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 451
            GA+Q   T++  T L  A   GH  V   L++ G   +V +PA      L +AA     
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
             AA+L++   N + ++  G+TPL  AA   +  +  LLL +GA++N  T +   T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245

Query: 512 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 568
           A   G   +   L+  GA IE       TPL  A++ GH+ + + LL  GA + A T  G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 569 DTALTYACENGHTDVADVLLQAGADLD 595
            + +  A +  H D   +LLQ  A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  173 bits (438), Expect = 5e-43
 Identities = 135/416 (32%), Positives = 204/416 (49%), Gaps = 24/416 (5%)

Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
           +T M  ++  NA      S   A   G+++ V + L  G  +N   + G + L LA   G
Sbjct: 1   MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54

Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
           +  L Q LL   ++V+    KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L
Sbjct: 55  HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
             A     +D+VK LL  GAN     E+G TPL  A   GH +   +LL+     N    
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168

Query: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
           + +  AL +A  K        LL  +  AD + K      T+   T L  A   G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            LLL+ GA V+  A +  +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR 
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
           GH+++V LLL +GA + A+T+    + L +A  G   E    L++  A   D+ L   T 
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
           L  A+  GH  + K LL   AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 37  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96

Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 97  KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155

Query: 319 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 341
             V +LL      +                        DHN             E+G TP
Sbjct: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215

Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 273

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392

Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452

Query: 578 NGHTDVADVLLQAGADLD 595
            G  +V   LL+ GA +D
Sbjct: 453 AGQVEVVRCLLRNGALVD 470



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 312 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 388
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426

Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 545

Query: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 566 ATGDTALTYACENGHTDVADVLLQAGAD 593
             G T L  A +     +A  LL  GA+
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAE 633



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 200 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 525 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583

Query: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 642

Query: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702

Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762

Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 763 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 820

Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 606
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 821 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 723 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781

Query: 314 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 365
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 840

Query: 366 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 407
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 888



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 35/102 (34%), Positives = 56/102 (54%), Gaps = 6/102 (5%)

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLL 555
           Q  ++  + L  A  G   +V ++L K G DI   C+      L  A++EGH+ LV+ LL
Sbjct: 6   QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINT-CNQNGLNALHLAAKEGHVGLVQELL 63

Query: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
             G++V + T  G+TAL  A   G  +V  VL++ GA+++ Q
Sbjct: 64  GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  172 bits (436), Expect = 8e-43
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 319 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 341
             V +LL      +                        DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 578 NGHTDVADVLLQAGADLD 595
            G  +V   LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 388
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447

Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566

Query: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 566 ATGDTALTYACENGHTDVADVLLQAGAD 593
             G T L  A +     +A  LL  GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 200 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663

Query: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841

Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 606
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  125 bits (314), Expect = 1e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131

Query: 521 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 581 TDVADVLLQ 589
                +LL+
Sbjct: 176 NQAVAILLE 184



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 314 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 365
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861

Query: 366 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 407
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  172 bits (436), Expect = 8e-43
 Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
             AN +A    G T L  AC+     V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424



 Score =  169 bits (429), Expect = 5e-42
 Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)

Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 319 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 341
             V +LL      +                        DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 578 NGHTDVADVLLQAGADLD 595
            G  +V   LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491



 Score =  168 bits (425), Expect = 2e-41
 Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A   G+ N V+ LLD G  ++  T +G + L  A  +G+ ++ ++LL   A +  R   G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
            ++PL  A+ G +++ VK LL H A V+  +    TAL  A   G   + K+LL++ AN 
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 388
                NG TPL  A     ++V  +L+ +GA I        ES LT   +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447

Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
             LL+ GA  +       TAL  A   G VEV R LL +GA V+  A   ++PL +A+  
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
           G  E+  LL++  A+ +     GYTPL  +AREG  ++ ++LL  GA  +  T++   T 
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566

Query: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
           L +A   G  +VA  L++  A  +       TPL  A+   + ++   LL  GA+ HAT 
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 566 ATGDTALTYACENGHTDVADVLLQAGAD 593
             G T L  A +     +A  LL  GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654



 Score =  141 bits (355), Expect = 2e-33
 Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)

Query: 200 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           N   VD R+  E      A   G    V+ LL      +  T  G + L ++   G  ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
           A VLL   A       K   TPL  A+  G LD+ KLLL   A  +S    G T L  A 
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604

Query: 314 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 373
                 +  +LL +GA+     +NG+TPL  AA    +++A  LL++GA  N  + +   
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663

Query: 374 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 433
           + L LA  +GH DMV  LL+ GA+    T    T+L  A  +  V VA +L   GA  + 
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723

Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
                 +PL +A   G+V++   L+++GAN+      GYTPL +AA++GH  ++ +LL  
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783

Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
           GA  NA T     TAL +A   G+  V D L K   +     +T + E  +    E +  
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841

Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 606
           +L         T TGD    Y       ++ D  L +   LD    ++  LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893



 Score =  125 bits (314), Expect = 1e-28
 Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)

Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ++             GF   
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131

Query: 521 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 580
                           TPL  A+QE H+++VKYLL +GAN    T  G T L  A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175

Query: 581 TDVADVLLQ 589
                +LL+
Sbjct: 176 NQAVAILLE 184



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)

Query: 194 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 253
           K  N H + +    SL  A  +  VN    L   G   + HT+ G + L +AC  G  ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743

Query: 254 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 313
              LL   ANV  +  K   TPL  A+  G+  I+ +LL H A  N+ +A GNTAL  A 
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802

Query: 314 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 365
             G+   VD +KV+  E         E H  N    + E       E    +   G G  
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861

Query: 366 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 407
               + KE    +L  + +   ++ +R+ LE G     +   +D  HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  169 bits (429), Expect = 5e-42
 Identities = 125/399 (31%), Positives = 202/399 (50%), Gaps = 7/399 (1%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             + +K  +TPL  A +    + V++LL H ADVN++     T L  A A   V   + L
Sbjct: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
           +   +N+   +  G T L  AA +GH E+ ++LL  GA IN    + +  A+  A Y GH
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185

Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
           +++V+ L+  GA+   K  + +T L  A   G + V + LLD G  +N P     +PL +
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503
           A   G   +   LI+ GA + + N++G+TPL  AA   H  + + LL+  GA++N ++++
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 504 TQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGAN 560
            +      A  G FS  +  +I++GA I+      +TPL  A++ GH  L+  L+ SGA+
Sbjct: 306 GKTPLHMTALHGRFSR-SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364

Query: 561 VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599
                  G   L  A  +G +D    LL +G D+D  +D
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403



 Score =  156 bits (394), Expect = 6e-38
 Identities = 122/395 (30%), Positives = 201/395 (50%), Gaps = 17/395 (4%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVEDRGN 269
           +CS+    AV+ LL     VN   +  ++ L +A +    + A+ L+ +  + NV DR  
Sbjct: 84  SCSE---EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140

Query: 270 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 329
           +   T L  A+  G+ ++VKLLL   A++N+       A+ +A   G +++VK+L++ GA
Sbjct: 141 R---TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197

Query: 330 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389
            +   ++  +TPL  AAS+G + V + LLD G  +N   N +  + L +ACY G   +V 
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN 256

Query: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACG 448
            L++ GA    K ++  T L  A    H  +   LL+ +GA VNM +   ++PL + A  
Sbjct: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 508
           G    +  +I+ GA ++  +  G TPL  AAR GHE ++  L+  GA+  A+        
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFP 375

Query: 509 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 565
           L LA   GFS+    L+ +G DI+       T L  A+  G+LE +  LL +GA+ +   
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 566 ATGDTALTYACENGHTDVADVLLQAGA---DLDKQ 597
             G + L YA  N +      L+ +GA   DLD++
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470



 Score =  139 bits (349), Expect = 1e-32
 Identities = 134/461 (29%), Positives = 207/461 (44%), Gaps = 25/461 (5%)

Query: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201
           ++  L+ L+E +G   LS +D +A   P  L         AL+    +L  +   NS   
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584

Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258
             +D      A   G V  V  L+++G S  V ++  +  + +  A + G+ E  ++L+ 
Sbjct: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638

Query: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
            A   N  D  +    TPLM +   G+ D V  LL   A+V+++   G TAL      G 
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374
            + V  LL  GA     +  G TP+  +A+ GH+ V   LL   A ++ +   ++    +
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758

Query: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433
           AL  ACY GH   V  LLE    Q+ + +   + L  A ++ +   A +L+D+ GA +  
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817

Query: 434 PADS-FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
             DS   +PL  AA   HVE   LL+   A +  V+  G TPLM AA  G    V +L++
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877

Query: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEG 546
             +      + ++ TAL LAC  G    A  +++   D  L         TPL  A++ G
Sbjct: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNG 937

Query: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
              +V+ LL  GA+V A    G T       N   DVAD L
Sbjct: 938 LTMVVQELLGKGASVLAVDENGYTPALACAPN--KDVADCL 976



 Score =  136 bits (343), Expect = 5e-32
 Identities = 109/352 (30%), Positives = 175/352 (49%), Gaps = 17/352 (4%)

Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601

Query: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778

Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKA-GADIELGCS----TPLMEASQEGHLEL 550
            +  +TE    + L  A        A+ LI   GA I         TPL  A+   H+E 
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838

Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLDKQEDMK 601
           ++ LL+  A V++  +TG T L  A ENG T+  ++L+  A A+L  Q++ K
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890



 Score =  132 bits (333), Expect = 7e-31
 Identities = 119/425 (28%), Positives = 194/425 (45%), Gaps = 14/425 (3%)

Query: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220
           A  K +  P  +     +V CA  EA   L      N + + +    +L  A   G    
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155

Query: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
           V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +  K   TPL AA+
Sbjct: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214

Query: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
           S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ GA +   NE G T
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274

Query: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           PL  AA++ H  +   +L+ +GA +N  S + K + L +    G     + ++++GA  +
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
            +    +T L  A   GH  +   L+ SGA           PL LAA  G  +    L+ 
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
            G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452

Query: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
               L+ +GA +    E GC+     A+ +   + ++YLL + AN       G  A+ Y+
Sbjct: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512

Query: 576 CENGH 580
              GH
Sbjct: 513 AAYGH 517



 Score =  132 bits (331), Expect = 1e-30
 Identities = 117/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
           LL  GANV A    G TAL      GH +  D LLQ GA
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710



 Score =  129 bits (325), Expect = 6e-30
 Identities = 119/403 (29%), Positives = 179/403 (44%), Gaps = 20/403 (4%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506

Query: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566

Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA +
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  167 bits (422), Expect = 4e-41
 Identities = 122/397 (30%), Positives = 201/397 (50%), Gaps = 11/397 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266
           L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    NV D
Sbjct: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112

Query: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
           RG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V +L+N
Sbjct: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY G   
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445
           +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SPL + 
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288

Query: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
           A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+     
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347

Query: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562
              L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SGA+ H
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407

Query: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 599
                G T L YA  N H    + L+  GA++++ +D
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444



 Score =  148 bits (374), Expect = 1e-35
 Identities = 114/376 (30%), Positives = 185/376 (49%), Gaps = 7/376 (1%)

Query: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
           L+ +   VN    E  + L +A   G  E+ ++L+   A V  + N   +TPL  A +  
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60

Query: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
             + V++L+ H ADVN++     T L  A A   V   +V++   +++   +  G T L 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
            AA  GHVE+  +LL  GA IN    + +  AL  A Y GHLD+V  L+  GA+   K  
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
           + +T L  A  +G + V + LL+ G +++       + L +A   G   +   LI+ GAN
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239

Query: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
           + + N+ G+TPL  AA   H  + + LL+  GA++N Q+++ +      A  G F+  + 
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298

Query: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
            LI+ G +I+      +TPL  A++ GH  L+  L  SGA+           L  A  N 
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358

Query: 580 HTDVADVLLQAGADLD 595
           H+D    LL +G ++D
Sbjct: 359 HSDCCRKLLSSGFEID 374



 Score =  137 bits (345), Expect = 3e-32
 Identities = 120/416 (28%), Positives = 185/416 (44%), Gaps = 39/416 (9%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           +L  A  +G V  V  LL +G ++N   ++    L  A   G+ ++  +L+   A V  +
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG  TPL AA+S G +++VK LL    +++  +  GNTAL  AC  G   +V  L++ 
Sbjct: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFK-------------- 372
           GAN+   N NG TPL  AA++ H  +   +L+++GA +N  S + K              
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 373 ------------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
                              + L +A   GH  ++  L  +GAD           L  A +
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356

Query: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
           + H +  R LL SG +++ P     + L  AA GG+VE   LL   GA+  + +  G TP
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI-EL 533
           L  AA   H   +  L+  GAN+N +T++   TAL  A           L  A  +  EL
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475

Query: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
             +  L E      LE   +LL + AN       G  ++ YA   GH    ++LL+
Sbjct: 476 ERARELKEKEATLCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528



 Score =  127 bits (319), Expect = 3e-29
 Identities = 123/420 (29%), Positives = 177/420 (42%), Gaps = 37/420 (8%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  A S+G +N V+ LL+ G  ++E    G + L +AC  G   +   L+   ANV    
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244

Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
           N G  TPL   AAS+ G L  ++LL+ + ADVN QS  G + L      G     + L+ 
Sbjct: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            G  I+  +++G+TPL  AA  GH  +   L   GA             L LA    H D
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
             R LL +G + +       T L  A   G+VE  +LL  SGA  +       +PL  AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421

Query: 447 CGGHVELAALLIERGANLEEVNDEGYTPL------------------------MEAAREG 482
              H      L+  GAN+ E +D G T L                        +E ARE 
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481

Query: 483 HEEMVAL----LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-- 536
            E+   L    LL   AN + + +E   +    A  G    +   L +  +  E   S  
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541

Query: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 594
             +PL  A+  GH + ++ LL S  ++      G TAL  A   GHT+  + L+  GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601



 Score =  126 bits (317), Expect = 5e-29
 Identities = 97/327 (29%), Positives = 154/327 (47%), Gaps = 6/327 (1%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           TPL  A+  G  +I++LL+L  A VN++     T L  A A    + V+VL+   A++  
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
            ++N  TPL  AA+   V+ A V++   + +N  S+    +AL  A   GH++MV  LL 
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
            GA+      +   AL  A   GH++V  LL++ GA+V        +PL  AA  G + +
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
              L+  G  ++E+N  G T L  A   G + +V  L+  GAN+N Q      T L  A 
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255

Query: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569
                 +  + L+  GAD+ +      +PL   +  G     + L+ +G  +      G+
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315

Query: 570 TALTYACENGHTDVADVLLQAGADLDK 596
           T L  A   GH  + + L  +GAD  K
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAK 342



 Score =  122 bits (305), Expect = 1e-27
 Identities = 114/397 (28%), Positives = 180/397 (45%), Gaps = 20/397 (5%)

Query: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVEDRGNKGDITPLMAASSG 282
           LL    + +   +EG + +  A + G+ +  ++LL   ++  E+  +    +PL  A+  
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552

Query: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI-EDHNENGHTP 341
           G+   +++LL    D++ +   G TAL  A   G  + V+ L+N GA+I    N    TP
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612

Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESA----LTLACYKGHLDMVRFLLEAGAD 397
           L  +   GH    R+LL+     N  + + K++     L LA   GH+D V  LLE  A+
Sbjct: 613 LHASVINGHTLCLRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
            +       TAL    M GH E  ++LL+    +        +PL  AA  GH    + L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730

Query: 458 IERGANLEEV---NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 514
           ++   + E+    +++GYTPL  A   G+E  + +LL Q      +      T L  A  
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAII 788

Query: 515 GGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
                 A  L+ A     + C      TPL  A+   H+E ++ LL   A V+A   +G 
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848

Query: 570 TALTYACENGHTDVADVLL-QAGADLD-KQEDMKTIL 604
           TAL  A ENG     D+L+  A ADL  K +D+ T L
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885



 Score =  114 bits (285), Expect = 3e-25
 Identities = 91/310 (29%), Positives = 147/310 (47%), Gaps = 7/310 (2%)

Query: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298

Query: 586 VLLQAGADLD 595
            L+Q G ++D
Sbjct: 299 TLIQNGGEID 308



 Score =  107 bits (268), Expect = 3e-23
 Identities = 78/244 (31%), Positives = 125/244 (51%), Gaps = 5/244 (2%)

Query: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
           +L+     +NT  +E K + L +A + G  +++  L+ +GA    K +   T L  A   
Sbjct: 1   MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59

Query: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475
              E  ++L+   A VN    ++++PL +AA    V+ A ++I   +++   +  G T L
Sbjct: 60  RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---E 532
             AA  GH EMV LLLA+GANINA  ++    AL  A   G  +V   LI  GA++   +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINA-FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178

Query: 533 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
               TPL  A+  G + +VK+LL  G  +      G+TAL  AC NG   V + L+  GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 593 DLDK 596
           ++++
Sbjct: 239 NVNQ 242



 Score =  104 bits (259), Expect = 3e-22
 Identities = 105/409 (25%), Positives = 175/409 (42%), Gaps = 47/409 (11%)

Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457

Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571

Query: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630

Query: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690

Query: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 543
           EE V +LL Q  +I  +    +                               TPL  A+
Sbjct: 691 EECVQMLLEQEVSILCKDSRGR-------------------------------TPLHYAA 719

Query: 544 QEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
             GH   +  LL    S  +       G T L +AC NG+ +  +VLL+
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768



 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 82/264 (31%), Positives = 122/264 (46%), Gaps = 10/264 (3%)

Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
           V+ +  KG  TPLM A + G++D V LLL  +A+V++    G TAL      G  + V++
Sbjct: 638 VDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQM 696

Query: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SALTLA 379
           LL +  +I   +  G TPL  AA+ GH      LL     ++     FK+    + L  A
Sbjct: 697 LLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ--MALSEEDCCFKDNQGYTPLHWA 754

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS--GAQVNMPADS 437
           CY G+ + +  LLE    ++       T L  A ++ H   A LLL +   + V+   D 
Sbjct: 755 CYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813

Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
             +PL  AA   HVE   LL+   A +  V++ G T LM AA  G    V +L+      
Sbjct: 814 GRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQAD 873

Query: 498 NAQTEETQETALTLACCGGFSEVA 521
               ++   T L LAC  G  + A
Sbjct: 874 LTVKDKDLNTPLHLACSKGHEKCA 897



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 77/275 (28%), Positives = 121/275 (44%), Gaps = 9/275 (3%)

Query: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688

Query: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA--GAD 397
           TPL  A   G+     VLL+         N F  + L  A    H +    LL A   + 
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSI 806

Query: 398 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 457
              + D+  T L  A    HVE  +LLL   A VN   +S ++ L +AA  G      +L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866

Query: 458 IERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
           +    A+L   + +  TPL  A  +GHE+   L+L
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 80/279 (28%), Positives = 122/279 (43%), Gaps = 46/279 (16%)

Query: 192 RMKAENSHNAGQVDTRS------LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLA 245
           R+  E + N   VD +       L  A + G ++AV  LL++  +V+     G + L   
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRG 685

Query: 246 CSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQS 302
              G+ E  Q+LL    ++  + ++G  TPL  A++ G+   +  LL   L + D   + 
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKD 744

Query: 303 ATGNTALTYACAGGFVDIVKVLLNEG---------------ANIEDH------------- 334
             G T L +AC  G  + ++VLL +                A I DH             
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS 804

Query: 335 ------NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
                 ++ G TPL  AA A HVE  ++LL H A +N   N  K +AL +A   G    V
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAV 863

Query: 389 RFLLE-AGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
             L+  A AD   K  +++T L  AC  GH + A L+LD
Sbjct: 864 DILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902



 Score = 34.3 bits (77), Expect = 0.36
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 4/94 (4%)

Query: 236 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG--GYLDIVKLLLL 293
           ++G + L  A  A + E  Q+LL   A V    N G    +MAA +G  G +DI  L+  
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNS 869

Query: 294 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             AD+  +    NT L  AC+ G      ++L++
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 19/62 (30%), Positives = 33/62 (53%)

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
           TPL  A+  G  E+++ L+ SGA V+A      T L  A  +   +   VL++  AD++ 
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 597 QE 598
           ++
Sbjct: 78  RD 79


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  167 bits (422), Expect = 4e-41
 Identities = 120/394 (30%), Positives = 210/394 (53%), Gaps = 12/394 (3%)

Query: 206 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL--AMHAN 263
           ++S+     + ++ A++ LL++ + V+E  E G++ L +A   G  E+ + L+    + N
Sbjct: 6   SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65

Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
           +ED  N    T L++AS  G++ IV+ LL    ++  +   G TAL +AC  G  D+V++
Sbjct: 66  LEDLDNW---TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122

Query: 324 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
           LL+ GAN          P++ AA  GH ++  +LL +GA +N  S+++  + L  A  KG
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC-SDKYGTTPLVWAARKG 181

Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
           HL+ V+ LL  GAD + +     TAL+ A   G+ +  + +L     VN+      + L 
Sbjct: 182 HLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALM 241

Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
           +A+  GH E+   L++ G  +   +  G T L+ A R GH E+V  LL + A+I+ + ++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301

Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGA 559
             +TAL  A   G + +   +++   D E+ C+    TPL++A++  ++E+V+ LL  GA
Sbjct: 302 -NKTALYWAVEKGNATMVRDILQCNPDTEI-CTKDGETPLIKATKMRNIEVVELLLDKGA 359

Query: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
            V A    GDT L  A       +A++LL+   D
Sbjct: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393



 Score =  166 bits (421), Expect = 5e-41
 Identities = 107/291 (36%), Positives = 163/291 (56%), Gaps = 6/291 (2%)

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76

Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 604
           L +G  V+    +GDT L  A   GH ++   LLQ  AD+D + +D KT L
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306



 Score =  139 bits (349), Expect = 1e-32
 Identities = 97/311 (31%), Positives = 154/311 (49%), Gaps = 5/311 (1%)

Query: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 585 DVLLQAGADLD 595
             +LQ   D +
Sbjct: 319 RDILQCNPDTE 329



 Score = 36.2 bits (82), Expect = 0.093
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358

Query: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  158 bits (400), Expect = 1e-38
 Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)

Query: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
           LS    G       PE  +R   E+ L ++G GK     G +  D     R + S+S   
Sbjct: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393

Query: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
           + + + L             V  + L +A   GD + + K+L + + V+   + G SLL 
Sbjct: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443

Query: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
           LA  AG  E A+ LL  +AN      +G  TPL  A       +V+LLL     VN++  
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502

Query: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
              TAL +A   G     ++LL + A++ + +  G TP+  A   G   + R+LL  G  
Sbjct: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562

Query: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
           ++      K++ L L  A ++GHL +V+ L  + G     +T +  T L  A   GH  V
Sbjct: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           AR+L+D  + VN+ +   ++PL +AA  GH   A LL+ RGA  E +  +GYT L  AAR
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
            GH   V LL+ + A++ A+    Q TAL LA   G SEV + L+ A   D+  E G S 
Sbjct: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738

Query: 538 PLMEASQEGHLELVKYLLASGANVH 562
            L  A+Q  H + V+ LL  GA+++
Sbjct: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  110 bits (276), Expect = 3e-24
 Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)

Query: 36  GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
           GV   +        +   S + SSG G   SG    D+A   +  L+ +  R        
Sbjct: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401

Query: 94  GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
            +D  +   V++ +  D   L   +     ++ L S A    L     + +     LL  
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
           A    LS   G       V RR+   V   L  A       K E+   A       L  A
Sbjct: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511

Query: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
             +GD ++ R LL++  SVNE   EG + + +AC  G   + ++LL    +V  +G K  
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570

Query: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
             PL  A+  G+L IVKLL       VN+Q+  G T L  A   G   + ++L++  +++
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
              +    TPL  AA  GH   AR+LL  GAG    +++   +AL LA   GHL  V+ L
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           +E  AD   +     TAL  A   GH EV   L+ S   +++  +   S L LAA G H 
Sbjct: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748

Query: 452 ELAALLIERGA--NLEEVNDEG 471
           +    L+  GA  NL+ +  +G
Sbjct: 749 QTVETLLRHGAHINLQSLKFQG 770



 Score =  106 bits (264), Expect = 7e-23
 Identities = 87/264 (32%), Positives = 127/264 (48%), Gaps = 8/264 (3%)

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++G + L  A  AG  E A+ LL + A  N  SN    + L +A  +    +V  LL   
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
                K ++  TAL  A  +G     RLLL+  A VN       +P+ +A   G   +  
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
           +L+ RG ++     + + PL  AA +GH  +V LL  Q G ++NAQT + + T L LA  
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613

Query: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
            G   VA  LI   +D+ + CS    TPL  A++ GH    + LL  GA   A T+ G T
Sbjct: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672

Query: 571 ALTYACENGHTDVADVLLQAGADL 594
           AL  A  NGH     +L++  AD+
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADV 696



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 54/196 (27%), Positives = 79/196 (40%), Gaps = 32/196 (16%)

Query: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
           TD     L++A + G       +L     V++  DS  S L LA   G  E A  L+   
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
           AN    N  G TPL  A       +V LLLA+  ++NA+ E+ Q TAL  A         
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFA--------- 511

Query: 522 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
                                +Q G     + LL   A+V+     G T +  AC++G  
Sbjct: 512 ---------------------AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550

Query: 582 DVADVLLQAGADLDKQ 597
           ++  +LL+ G D+  Q
Sbjct: 551 NIVRILLRRGVDVSLQ 566



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 3/107 (2%)

Query: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
           T + Q+  L  A   G  S++   L     D+ L     L+  + E G  E  K+LL + 
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 604
           AN + +   G T L  A E     V ++LL     ++ K ED  T L
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 508


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  154 bits (389), Expect = 2e-37
 Identities = 123/353 (34%), Positives = 167/353 (47%), Gaps = 6/353 (1%)

Query: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598
                V  LL   ANVHA    G T    A   G+T +  VL++AGA LD Q+
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722



 Score =  131 bits (330), Expect = 2e-30
 Identities = 110/365 (30%), Positives = 173/365 (47%), Gaps = 6/365 (1%)

Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
           + G V  VR LL     V+  T  G + L +A      +L  +LLA H    +R ++   
Sbjct: 371 AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADANRVDEDGW 429

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
            PL  A+  G     +LLL H A V++Q   G T L  A    F ++ ++L++  A+   
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
           H   G TPL  AA  GHV + ++L   GA ++      + + L LA  +G +  ++ LL+
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLK 548

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
           +GA  +      +  L  A   G   + ++LL  GA + +P     +PL LAA  GH+E+
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
             LL E  AN+  +    +TPL  AAR G E +V+ LL  GA+ NA  E++  T L LA 
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAV 667

Query: 514 CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
                     L++  A++        TP   A+ +G+  ++K L+ +GA +        T
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727

Query: 571 ALTYA 575
            L  A
Sbjct: 728 PLQLA 732



 Score =  117 bits (293), Expect = 3e-26
 Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
             TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL  GA  
Sbjct: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
           +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL+++  L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
                L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 78/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)

Query: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380

Query: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440

Query: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499

Query: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 568 GDTALTYACENGHTDVADVLLQAGADLD 595
           G   L  A   G   +  +LL+ GA L+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLE 587



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 22/63 (34%), Positives = 35/63 (55%)

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
           TPL     +G +E V+ LLA   +V   TA+G T L  A ++   D+  +LL  GAD ++
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423

Query: 597 QED 599
            ++
Sbjct: 424 VDE 426


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  148 bits (374), Expect = 1e-35
 Identities = 117/364 (32%), Positives = 181/364 (49%), Gaps = 23/364 (6%)

Query: 252  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310
            +++++L+   AN+  R    +  P++   S  GY ++V LLL   A+V++ S +G T L 
Sbjct: 864  KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923

Query: 311  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD-------HGAG 363
            YA A G++ IV +L  + A ++  ++NG   L+ AA  GH+EV + L+           G
Sbjct: 924  YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983

Query: 364  INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM----------HTALMEAC 413
            +   S+  ++ AL  A   G+ ++V +LL+     E + +             TAL  A 
Sbjct: 984  VFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042

Query: 414  MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 473
              G +EV RLLL+ GA V  P      PL      GH ++  LL+  GA++   + +G T
Sbjct: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102

Query: 474  PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---D 530
            PLM AA EGH   V  LLAQGA+I A  ++   TAL+ AC  G   V   L+  GA    
Sbjct: 1103 PLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161

Query: 531  IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
             +    TPL  A+  G  E+V++L+  GA +     +G   L  A    +T V   LL+ 
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221

Query: 591  GADL 594
            GA +
Sbjct: 1222 GAKI 1225



 Score =  144 bits (364), Expect = 2e-34
 Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            ++   R L+  G ++N  TE      +LC+    GY E+  +LL   ANV D  ++  +T
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 327
            PL  A++ GYL IV LL    A V+     G  AL +A   G +++VK L+        +
Sbjct: 921  PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980

Query: 328  GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 378
               +   +      L+ AAS G+ E+   LLD           A IN+  + + E+ALT 
Sbjct: 981  QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040

Query: 379  ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
            A  +G L++ R LLE GA            L      GH ++  LLL  GA VNM     
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100

Query: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
             +PL +AA  GH+     L+ +GA++  ++ EG T L  A  +GH  +V  L+  GA  +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160

Query: 499  AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 555
               ++   T L LA   G +EV  FL+  GA IE        PL  A    +  +V  LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219

Query: 556  ASGANVHATT 565
              GA +   T
Sbjct: 1220 KKGAKIGPAT 1229



 Score =  140 bits (352), Expect = 5e-33
 Identities = 109/334 (32%), Positives = 172/334 (51%), Gaps = 26/334 (7%)

Query: 285  LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
            + + +LL+L  A++N ++   N A  L      G+ ++V +LL  GAN++  +E+G TPL
Sbjct: 863  IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922

Query: 343  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
              AA+AG++ +  +L    A ++ H ++  + AL  A  +GHL++V+FL++     AG  
Sbjct: 923  GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981

Query: 398  QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
            Q    K+  +  AL+ A   G+ E+   LLD           AQ+N   DS   E+ LT 
Sbjct: 982  QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040

Query: 445  AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
            AA  G +E+  LL+E+GA + + N  G  PL    R+GH ++V LLL  GA++N   ++ 
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQ 1099

Query: 505  QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 561
              T L +A   G     DFL+  GA I L      T L  A  +GHL +V+ L+ +GA  
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159

Query: 562  HATTATGDTALTYACENGHTDVADVLLQAGADLD 595
                  G T L  A   G  +V   L+  GA ++
Sbjct: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193



 Score =  132 bits (333), Expect = 7e-31
 Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G +V+  +E G + L  A +AGY  +  +L    A V+     G    
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L+AA+S GY +IV  LL    
Sbjct: 956  VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015

Query: 293  -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
                 +  A +NS  S  G TALT A   G +++ ++LL +GA +   N  G  PL    
Sbjct: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075

Query: 347  SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
              GH ++  +LL HGA +N    + + + L +A  +GHL  V FLL  GA       E  
Sbjct: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134

Query: 407  TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
            TAL  AC+ GH+ V R L+D+GA  +    +  +PL LAA  G  E+   L++ GA +E 
Sbjct: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194

Query: 467  VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
            V+  G  PL  A    +  +V  LL +GA I   T    T +  + +       E  D  
Sbjct: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254

Query: 525  IKAG 528
             K G
Sbjct: 1255 YKKG 1258



 Score = 36.6 bits (83), Expect = 0.072
 Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)

Query: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
            +L+ AC  G ++ VR L+D G + +   + G + L LA   G  E+ Q L+   A +E  
Sbjct: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
               G + PL  A       +V  LL   A +           T+A A    DI+ +LL++
Sbjct: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246


>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score =  148 bits (373), Expect = 2e-35
 Identities = 144/446 (32%), Positives = 198/446 (44%), Gaps = 61/446 (13%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160

Query: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220

Query: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280

Query: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340

Query: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLDKQE-------DMK 601
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+  +        D+ 
Sbjct: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLV 400

Query: 602 TILEGIDPAKHQVRVAFDACKLLRKE 627
            +L   DP    VR+    C  + K+
Sbjct: 401 MLLN--DPDTELVRLLASVCMQVNKD 424


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  146 bits (369), Expect = 5e-35
 Identities = 115/391 (29%), Positives = 191/391 (48%), Gaps = 7/391 (1%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185

Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245

Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305

Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGAN 560
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA+
Sbjct: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364

Query: 561 VHATTATGDTALTYACENGHTDVADVLLQAG 591
                      L  A   G +D    LL +G
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395



 Score =  126 bits (317), Expect = 5e-29
 Identities = 127/437 (29%), Positives = 201/437 (45%), Gaps = 22/437 (5%)

Query: 183 LDEAAAALTRMKAE----NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG 238
           L  AAA+ T  +AE    +SH+A + +   L E+        +  LLD G   +    +G
Sbjct: 493 LHYAAASDTYRRAEPHTPSSHDAEEDEP--LKESRRKEAFFCLEFLLDNGADPSLRDRQG 550

Query: 239 ESLLCLACSAGYYELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297
            + +  A + G  +  ++LL M  N +ED  +   ++PL  A+  G+ + +K L     +
Sbjct: 551 YTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVN 610

Query: 298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARV 356
           ++ +   G TAL  A   G  + V+VL   GA+ +    +   TPL  AA++GH +   +
Sbjct: 611 LDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHL 670

Query: 357 LLDHG--AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
           L+D G  A I    + + ++ L LA   GH+D V  LLE G+  +       TAL    +
Sbjct: 671 LIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAV 730

Query: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDE 470
            G  +    LLD  A V        +P+ LA+  GH  +   L++   + +     V+  
Sbjct: 731 TGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYS 790

Query: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GA 529
           GY+P+  A+  GHE+ + LLL       +  E    T L  A         + L+ A GA
Sbjct: 791 GYSPMHWASYTGHEDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGA 848

Query: 530 DI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
            I    +    TPL  A+   ++  ++ LL   A V+AT  TG TAL  A ENG T   +
Sbjct: 849 KIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVE 908

Query: 586 VLLQAG-ADLDKQEDMK 601
            LL  G ADL   ++ K
Sbjct: 909 FLLYRGKADLTVLDENK 925



 Score =  122 bits (307), Expect = 8e-28
 Identities = 143/566 (25%), Positives = 219/566 (38%), Gaps = 103/566 (18%)

Query: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177
           E+     A GADL   D +    L     AA  G++         G    +P        
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243

Query: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233
            ++C L + A A+  + A    N  Q + +        A S      +  L++ G  VN 
Sbjct: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301

Query: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292
            ++EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+ 
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360

Query: 293 ---------LHDA-----------------------------------------DVNSQS 302
                    +HD                                          D+N+  
Sbjct: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420

Query: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
             G T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GA
Sbjct: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480

Query: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394
           G+N                            +H  E ++  L  +  K     + FLL+ 
Sbjct: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539

Query: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452
           GAD   +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
               L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659

Query: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
              G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A   
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719

Query: 567 TGDTALTYACENGHTDVADVLLQAGA 592
            G TAL      G  D    LL   A
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDA 745



 Score =  110 bits (274), Expect = 5e-24
 Identities = 88/264 (33%), Positives = 127/264 (48%), Gaps = 9/264 (3%)

Query: 341 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           PL++A  +  VE  R LL     IN    E + + L  A Y G + +++ LL +GA+   
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           K     T L  A    + +V  LLL   A VN     +++PL +AA     + A  L   
Sbjct: 70  KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            ++L   +  G + L  A   GH E V LLL +GA++N   ++ +   L  A   G  EV
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEV 188

Query: 521 ADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
              L+  GAD  LGC        L  A+  G +E+VKYLL  GA +    A G+TAL  A
Sbjct: 189 LKLLVARGAD--LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246

Query: 576 CENGHTDVADVLLQAGADLDKQED 599
           C  G   VA  L+ AGA++++  D
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPND 270



 Score =  105 bits (262), Expect = 1e-22
 Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)

Query: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 259
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A            
Sbjct: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 260  ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 295
                +HA              D G + DIT         PLM A   G++D V LLL   
Sbjct: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 296  ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
            +  ++    G TAL      G  D +  LL+  A +   +  G TP+  A++ GH  V R
Sbjct: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771

Query: 356  VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412
             LL        ++   +    S +  A Y GH D +  LLE  +   +      T L  A
Sbjct: 772  TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830

Query: 413  CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
             ++       +LL + GA+ VN       +PL  AA   +V    +L++  A +   +  
Sbjct: 831  VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890

Query: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
            G T LM AA  G    V  LL +G       +E + TAL LAC  G  + A  ++    D
Sbjct: 891  GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950

Query: 531  IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
            + L  +T      PL  A++ G   +V+ LL+ GA V A    G T       N   DVA
Sbjct: 951  LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008

Query: 585  DVL 587
            D L
Sbjct: 1009 DCL 1011



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817

Query: 265  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875

Query: 323  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935

Query: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
            GH      +L    D                                 +N    + + PL
Sbjct: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965

Query: 443  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 264  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909

Query: 324  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026



 Score = 35.4 bits (80), Expect = 0.16
 Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 31/127 (24%)

Query: 474 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 533
           PL++A      E V  LL+Q  NIN   +E +                            
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---------------------------- 42

Query: 534 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
              TPL  A+  G + +++ LL SGANV+A      T L  A  + +  V  +LL   AD
Sbjct: 43  ---TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD 99

Query: 594 LDKQEDM 600
           ++ ++ +
Sbjct: 100 VNARDKL 106


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  143 bits (361), Expect = 4e-34
 Identities = 139/437 (31%), Positives = 199/437 (45%), Gaps = 54/437 (12%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 264
           R L EAC +GDV+ V++L+D   +VN     G   S L  A   G  ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             R + G + PL  A S G+ ++V LLL   AD N++     T L  A   G +D+  VL
Sbjct: 243 HAR-DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
           L  GA+    N +G +                     L+EAA +G+ E    LL     +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNV 360

Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
           LL  GA VN       +PL  AA    VE+ +LL+  GA+   VN       D   TP  
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG---GFSE 519
                       L++AARE     V   LA    IN +  ++ ETAL  A         +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539

Query: 520 VADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
           V + L++ GA++        TPL  A++  H ++++ L   GA ++A    G TAL  A 
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 577 ENGHTDVADVLLQAGAD 593
             GH     +LL  G+D
Sbjct: 600 LAGHLQTCRLLLSYGSD 616



 Score =  132 bits (331), Expect = 1e-30
 Identities = 139/494 (28%), Positives = 205/494 (41%), Gaps = 84/494 (17%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
           L EA   G ++    LL  G   N    +G+S L LA  +      G Y+  ++L A  +
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345

Query: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
             E++                G K   TPL  A+    + IV+LLL H ADV+++   G 
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
             L  AC+ G  ++ ++LL  GA +   +    TPL EAAS   VEV  +LL HGA    
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463

Query: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
           +N H                   EFK  +L  A  +  L  V+  L        +     
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523

Query: 407 TALMEACMDGHV---EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
           TAL  A    H    +V  LLL  GA VN     F +PL +AA   H ++  +L + GA 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA------------------------ 499
           +  ++  G T L  AA  GH +   LLL+ G++ +                         
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643

Query: 500 --QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYL 554
             +T +     L  +  G    V            D+E   STPL  A+    + +V+YL
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703

Query: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK--TILEGIDPAKH 612
           L  GA+VHA    G   L  AC  GH +VA++L++ GA ++  +  K   + E     K+
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763

Query: 613 QVRVAFDACKLLRK 626
           ++      CKLL K
Sbjct: 764 EI------CKLLLK 771



 Score =  131 bits (329), Expect = 2e-30
 Identities = 129/441 (29%), Positives = 199/441 (45%), Gaps = 59/441 (13%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
           SL +A  + D+  V+K L       +  +  E+ L  A ++ + +  QV   LL   ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            ++ NK  +TPL  A+   + D++++L  H A +N+    G TAL  A   G +   ++L
Sbjct: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 325 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 358
           L+ G++    +  G T                           L+EA+ AG +E  + L 
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670

Query: 359 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 417
                +N    E + S  L  A     + +V +LL  GAD   K       L  AC  GH
Sbjct: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729

Query: 418 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
            EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL 
Sbjct: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787

Query: 477 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 515
           +  +EG  ++  LL    A                    NIN + T+    T L LA   
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 516 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
              EVA++L++ GAD+   + G   PL  A+  GH+++   L+     V+AT     T L
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 573 TYACENGHTDVADVLLQAGAD 593
             A + G T +  +LL  GAD
Sbjct: 908 HEAAQKGRTQLCALLLAHGAD 928



 Score =  112 bits (279), Expect = 1e-24
 Identities = 104/314 (33%), Positives = 153/314 (48%), Gaps = 25/314 (7%)

Query: 220 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG-DITPLMA 278
           AV+++L E   +   T + +  L  A  AG  E  + L +   NV  R  +G   TPL  
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690

Query: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
           A+    + +V+ LL H ADV+++   G   L  AC+ G  ++ ++L+  GA++   +   
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750

Query: 339 HTPLMEAASAGHVEVARVLLDHGAGI-------NTHSNEFKE------------SALTLA 379
            TPL EAA+ G  E+ ++LL HGA         NT  +  KE            +AL  A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
             KG L  V+ L          T   + T L  A    ++EVA  LL+ GA VN      
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870

Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
             PL  AA  GHV++AALLI+    +   +   +TPL EAA++G  ++ ALLLA GA+  
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930

Query: 499 AQTEETQETALTLA 512
            + +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A    ++     LL+ G  VN   + G   L  A S G+ ++A +L+  +  V +  +K 
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
             TPL  A+  G   +  LLL H AD   ++  G T L  A A    D ++ LL
Sbjct: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  142 bits (359), Expect = 7e-34
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 252  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 906  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965

Query: 311  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 361
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 966  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025

Query: 362  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 414
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 1026 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1080

Query: 415  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140

Query: 475  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 533
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1199

Query: 534  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259

Query: 592  ADL 594
            A L
Sbjct: 1260 AKL 1262



 Score =  131 bits (330), Expect = 2e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022

Query: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261

Query: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589
            +      G+ A  +A      D+  +LLQ
Sbjct: 1262 L------GNAA--WAMATSKPDILIILLQ 1282



 Score =  129 bits (323), Expect = 1e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L AA+S G+  +V+ LL    
Sbjct: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057

Query: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117

Query: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176

Query: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236

Query: 472  YTPLMEAAREGHEEMVALLLAQGANI 497
              PL  A    +  +V  LL +GA +
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262



 Score =  128 bits (321), Expect = 2e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966

Query: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025

Query: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085

Query: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138

Query: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174

Query: 573  TYACENGHTDVADVLLQAGADLDKQE 598
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 1175 SWACLKGHRAVVQYLVEEGAAIDQTD 1200



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133

Query: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193

Query: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252

Query: 322  KVLLNEGANI 331
              LL +GA +
Sbjct: 1253 VALLRKGAKL 1262


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  142 bits (359), Expect = 7e-34
 Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)

Query: 252  ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 310
            +++++L+   ANV  R    +  P++   S  G+ ++V LLL   A ++  S  G TAL 
Sbjct: 914  KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973

Query: 311  YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 361
            YA A G + +V +L  +G  ++  ++ G   L+ +A  GH ++ + LL           G
Sbjct: 974  YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033

Query: 362  AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 414
                +H+    + ALT A   GH  +V+ LL  G ++EH+     TD +   TAL  A  
Sbjct: 1034 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1088

Query: 415  DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
             G +EV  LLL  GA V+        PL  AA  GH ++  LL+ERG ++   + +G TP
Sbjct: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148

Query: 475  LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 533
            LM AA EGH   V  LL++GA +++  +E   +AL+ AC  G   V  +L++ GA I+  
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1207

Query: 534  --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
                 TPL  A+  G  E V YL+  GA +     +G   L  A    +T V   LL+ G
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267

Query: 592  ADL 594
            A L
Sbjct: 1268 AKL 1270



 Score =  131 bits (330), Expect = 2e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 971  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030

Query: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269

Query: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589
            +      G+ A  +A      D+  +LLQ
Sbjct: 1270 L------GNAA--WAMATSKPDILIILLQ 1290



 Score =  129 bits (323), Expect = 1e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 946  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L AA+S G+  +V+ LL    
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065

Query: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125

Query: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184

Query: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244

Query: 472  YTPLMEAAREGHEEMVALLLAQGANI 497
              PL  A    +  +V  LL +GA +
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270



 Score =  128 bits (321), Expect = 2e-29
 Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)

Query: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 915  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974

Query: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 975  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033

Query: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093

Query: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146

Query: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182

Query: 573  TYACENGHTDVADVLLQAGADLDKQE 598
            ++AC  GH  V   L++ GA +D+ +
Sbjct: 1183 SWACLKGHRAVVQYLVEEGAAIDQTD 1208



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141

Query: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201

Query: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260

Query: 322  KVLLNEGANI 331
              LL +GA +
Sbjct: 1261 VALLRKGAKL 1270


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  142 bits (359), Expect = 7e-34
 Identities = 129/440 (29%), Positives = 205/440 (46%), Gaps = 57/440 (12%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
           SL +A  + DV  ++K L       +H +  E+ L  A ++ Y    ++ ++LL   AN+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            ++  K  +TPL  AS   + D+V++++ H+A VN+    G T+L  A   G +   ++L
Sbjct: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
           L+ G +           ++  NEN    L E  S G+ E  R LL+              
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512

Query: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
               +N    E ++S  L  A     + +V +LL+ GAD   K       L  AC  GH 
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572

Query: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
           EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL +
Sbjct: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630

Query: 478 AAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCGG 516
             ++G  ++  LL    A                    N+N + T+    T L LA    
Sbjct: 631 LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690

Query: 517 FSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
             EVA++L++ GAD+   + G   PL  A+  GH+++   L+   A V+AT     T L 
Sbjct: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750

Query: 574 YACENGHTDVADVLLQAGAD 593
            A + G T +  +LL  GAD
Sbjct: 751 EAAQKGRTQLCALLLAHGAD 770



 Score =  139 bits (351), Expect = 6e-33
 Identities = 133/437 (30%), Positives = 198/437 (45%), Gaps = 54/437 (12%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
           R L EAC +GDV  V++L+     VN     G     L  +AG+   ++ + LL   ANV
Sbjct: 26  RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
           + R + G + PL  A S G+ ++V LLL H AD N++     T L  A   G +D+  VL
Sbjct: 85  QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143

Query: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
           L  GA     N +G T                     L+E+A +G+ E    LL     +
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202

Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262

Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
           L+  GA VN       +PL  AA    VE+ +LL+  GA+   +N       D   TP  
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322

Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
                       L++AARE     +   L+    +N +  +T ETAL  A    +    +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381

Query: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
           + + L++ GA+I        TPL  AS++ H ++V+ ++   A V+A    G T+L  A 
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 577 ENGHTDVADVLLQAGAD 593
             GH     +LL  G D
Sbjct: 442 YCGHLQTCRLLLSYGCD 458



 Score =  120 bits (301), Expect = 4e-27
 Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
           R L EA   GDV  V+KL    +SVN    EG     L  +AGY  ++ V  LL   A+V
Sbjct: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             + +KG + PL  A S G+ ++ +LL+ H A VN       T L  A A G  +I K+L
Sbjct: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
           L  GA+    N +G+TPL +    G  ++  +L               ++AL  A  KG 
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657

Query: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
           L  V+ L          T   H T L  A    ++EVA  LL  GA VN        PL 
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717

Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            AA  GHV++AALLI+  A +   +   +TPL EAA++G  ++ ALLLA GA+   + +E
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777

Query: 504 TQ 505
            Q
Sbjct: 778 GQ 779



 Score =  119 bits (298), Expect = 8e-27
 Identities = 126/455 (27%), Positives = 199/455 (43%), Gaps = 49/455 (10%)

Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLA 259
           G+     L E+   G+   +  LL    +VN H  +G     L  +AGY   ++ Q+LL 
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232

Query: 260 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 319
             A+V  + +KGD+ PL  A S G+ ++ +LL+ H A VN+      T L  A +   V+
Sbjct: 233 HGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291

Query: 320 IVKVLLNEGAN---IEDHNEN-------------------GHTPLMEAASAGHVEVARVL 357
           +  +LL+ GA+   +  HN++                   GH+ L  A  A    + + L
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351

Query: 358 LDHGAGINTHSNEFKESALTLAC---YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
                 +N    +  E+AL  A    Y     +   LL  GA+   KT E  T L  A  
Sbjct: 352 SLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409

Query: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
             H +V  +++   A+VN   +  ++ L  AA  GH++   LL+  G +   ++ +G+T 
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 531
           L         E V  LL +G ++     E     L  A  G    V            DI
Sbjct: 470 LQMG-----NENVQQLLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 522

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           E   STPL  A+    + +V+YLL  GA+VHA    G   L  AC  GH +VA++L++ G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582

Query: 592 ADLDKQEDMK--TILEGIDPAKHQVRVAFDACKLL 624
           A ++  +  K   + E     K+++      CKLL
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEI------CKLL 611



 Score =  102 bits (255), Expect = 8e-22
 Identities = 99/316 (31%), Positives = 144/316 (45%), Gaps = 18/316 (5%)

Query: 162 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAV 221
           +G +  + E  R+L  +      E    L  +++ N  +     +  L  A     V+ V
Sbjct: 483 EGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVV 542

Query: 222 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASS 281
             LL  G  V+   + G   L  ACS G+YE+A+ LL  H  V +  +    TPL  A++
Sbjct: 543 EYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLHEAAA 601

Query: 282 GGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTP 341
            G  +I KLLL H AD   ++  GNT L         D+VK   +   +I+D    G   
Sbjct: 602 KGKYEICKLLLQHGADPTKKNRDGNTPL---------DLVK---DGDTDIQD-LLRGDAA 648

Query: 342 LMEAASAGHVEVARV-LLDHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQE 399
           L++AA  G   +ARV  L     +N    + + S  L LA    +L++  +LL+ GAD  
Sbjct: 649 LLDAAKKGC--LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
            +       L  A   GHV+VA LL+   A VN       +PL  AA  G  +L ALL+ 
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766

Query: 460 RGANLEEVNDEGYTPL 475
            GA+    N EG TPL
Sbjct: 767 HGADPTLKNQEGQTPL 782



 Score =  100 bits (248), Expect = 5e-21
 Identities = 143/541 (26%), Positives = 206/541 (38%), Gaps = 129/541 (23%)

Query: 175 LTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 234
           L  S     +E   AL      N H +    +  L  A     V  V+ LL  G  V  H
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--H 238

Query: 235 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
            ++   L+ L  ACS G+YE+ + LL  H    +  +    TPL  A+S   +++  LLL
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297

Query: 293 LH-----------------------------------------DADVN------------ 299
            +                                         +ADV             
Sbjct: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357

Query: 300 -SQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
                T  TAL  A A  +     I ++LL +GANI +  +   TPL  A+   H +V  
Sbjct: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417

Query: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
           V++ H A +N   N   +++L  A Y GHL   R LL  G D    + +  TAL      
Sbjct: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472

Query: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTP 474
           G+  V +LL +  +  N  AD     L  AA  G VE +  L   +  N  ++     TP
Sbjct: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI--- 531
           L  AA      +V  LL  GA+++A+ ++     L  AC  G  EVA+ L+K GA +   
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGA-----NVHATTAT---------------GDTA 571
           +L   TPL EA+ +G  E+ K LL  GA     N    T                 GD A
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAA 648

Query: 572 LTYACENG----------------------------------HTDVADVLLQAGADLDKQ 597
           L  A + G                                  + +VA+ LLQ GAD++ Q
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708

Query: 598 E 598
           +
Sbjct: 709 D 709



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 26/215 (12%)

Query: 409 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
           L EAC +G VE V RL+          A    +PL  AA  G  ++   L++ GAN++  
Sbjct: 28  LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
           +D G  PL  A   GH E+V LLL  GA+ NA+ +    T L  A   G  +V   L++ 
Sbjct: 88  DDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 528 GAD---------IELGCSTP--------------LMEASQEGHLELVKYLLAS-GANVHA 563
           GA+           L  + P              L+E+++ G+ E +  LL     N HA
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206

Query: 564 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 598
           +     T L  A       +  +LLQ GAD+  ++
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 27/64 (42%), Positives = 40/64 (62%)

Query: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
           STPL  A+  G  ++V+YLL +GANV A    G   L  AC  GH +V ++LL+ GAD +
Sbjct: 59  STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 596 KQED 599
            +++
Sbjct: 119 ARDN 122



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 5/88 (5%)

Query: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVHATTATGDTA 571
           C GG +  A     A A+     +  L EA + G +E VK L+     N   T     T 
Sbjct: 6   CAGGGAACAS----AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTP 61

Query: 572 LTYACENGHTDVADVLLQAGADLDKQED 599
           L +A   G  DV + LLQ GA++  ++D
Sbjct: 62  LHFAAGFGRKDVVEYLLQNGANVQARDD 89


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  140 bits (353), Expect = 4e-33
 Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L +A  DGD  A++ ++ EG+++ E  +EG   L  A   G     +VL   +    D+ 
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
              + T +  A+  G+LD +  LL   A+ +  + +  T L  AC     + VK+L+   
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           A+       G T L E+ S   +EV ++L+  GA + +  N +  + L +A   G L+ +
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239

Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
           RFL + GAD   +  +  +AL EAC + H EV   LL  GA  N        PL +A+  
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
           G+  +  +L+    +   +   G +PL  AA   H+E++  LL+   ++N          
Sbjct: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358

Query: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
            E+ + +AL  A         + L++ GAD      +PL+ A + G L  ++ LL  GAN
Sbjct: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418

Query: 561 VHATTATGDTA 571
           + A  AT  TA
Sbjct: 419 IDAYIATHPTA 429



 Score =  103 bits (258), Expect = 4e-22
 Identities = 92/329 (27%), Positives = 148/329 (44%), Gaps = 45/329 (13%)

Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
           L  A   G  + +K ++ EG N+ + N+ G  PL EAA  G V   +VL     G     
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQE---------------------------HK 401
              +E+A+ LA  +GHLD +  LL+AGA+ +                           H 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 402 TDEMH------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
            D  H      TAL E+     +EV ++L+  GA+V        +PL +AA  G +E   
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
            L + GA++     +  + L EA +  HEE+V  LL+QGA+ N +T +     L +A   
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIASKK 299

Query: 516 GFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA------- 566
           G   +   L+   +   +  S  +PL  A++  H E+++ LL++  +V+   A       
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359

Query: 567 --TGDTALTYACENGHTDVADVLLQAGAD 593
                +AL +A  N +    ++LLQ GAD
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGAD 388



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 63/225 (28%), Positives = 105/225 (46%), Gaps = 5/225 (2%)

Query: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMP 434
           L  A   G  + ++ +++ G +      E    L EA   G V   ++L  +    ++  
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
               E+ + LA C GH++    L++ GA  +  N    TPL +A    + E V +L+   
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 495 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551
           A+ N +      TAL  +      EV   L+  GA +E   +   TPL  A+Q G LE +
Sbjct: 181 ADTNHRCNRGW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239

Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
           ++L   GA+++   +   +AL  AC+N H +V + LL  GAD +K
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 7/167 (4%)

Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
           PAD    PL  A   G  E    +I+ G NL E N EG+ PL EAA  G    + +L   
Sbjct: 57  PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112

Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
                 Q    +ETA+ LA C G  +    L++AGA+ ++      TPL +A +  + E 
Sbjct: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172

Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
           VK L+   A+ +     G TAL  +      +V  +L+  GA ++ +
Sbjct: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  127 bits (320), Expect = 2e-29
 Identities = 89/304 (29%), Positives = 149/304 (49%), Gaps = 5/304 (1%)

Query: 293 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVE 352
           L + DVN  +  G   L  A   G + I+++L+  G+ I+  ++ G   +  AA  GHV+
Sbjct: 367 LSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD 426

Query: 353 VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 412
             + L ++   ++   ++  E AL +A   GH D+ + L   G++   +  E  T L  A
Sbjct: 427 TLKFLSENKCPLDV-KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485

Query: 413 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472
              G+  VA+ L ++G  VN+     E+PL  A+  G+ ++   L E GA+L   + +G+
Sbjct: 486 AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545

Query: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
             L  A R    E++  LL+QG  ++ Q +    T L +AC  G   +   L +A  +++
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIVVALCEANCNLD 604

Query: 533 LGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
           +      TPL  A+  G L++V+YL   GA+V A T  G TA   A    H  VA +L +
Sbjct: 605 ISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664

Query: 590 AGAD 593
              D
Sbjct: 665 LRKD 668



 Score =  117 bits (292), Expect = 4e-26
 Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 5/269 (1%)

Query: 330 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 389
           ++   N++G  PL+ AA  G++++ ++L+  G+ I+   ++   +A+  A   GH+D ++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ-DKGGSNAVYWAARHGHVDTLK 429

Query: 390 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 449
           FL E     + K      AL  A   GH +VA+LL   G+  N+     E+PL  AA  G
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489

Query: 450 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
           +  +A  L E G N+   N EG TPL+ A+  G+ ++V  L   GA++NA  ++    AL
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA-CDKDGHIAL 548

Query: 510 TLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
            LA      EV   L+  G  ++      +TPL  A ++G++ +V  L  +  N+  +  
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNK 608

Query: 567 TGDTALTYACENGHTDVADVLLQAGADLD 595
            G T L  A  NG  DV   L   GA ++
Sbjct: 609 YGRTPLHLAANNGILDVVRYLCLMGASVE 637



 Score =  116 bits (290), Expect = 7e-26
 Identities = 94/330 (28%), Positives = 154/330 (46%), Gaps = 5/330 (1%)

Query: 207 RSLAEACSDGDVNAVRKLLDE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           +++  A +D +V  ++ LL       VN+  + G   L +A   G  ++ Q+L+   + +
Sbjct: 346 KAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRI 405

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            D  +KG    +  A+  G++D +K L  +   ++ +  +G  AL  A   G  D+ ++L
Sbjct: 406 -DVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
            + G+N    ++   TPL  AA  G+  VA+ L + G  +N  + E  E+ L  A  +G+
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE-GETPLLTASARGY 523

Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
            D+V  L E GAD      + H AL  A     +EV + LL  G  V+       +PL +
Sbjct: 524 HDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV 583

Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
           A   G++ +   L E   NL+  N  G TPL  AA  G  ++V  L   GA++ A T + 
Sbjct: 584 ACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTD- 642

Query: 505 QETALTLACCGGFSEVADFLIKAGADIELG 534
            +TA  LA       VA  L +   D   G
Sbjct: 643 GKTAEDLARSEQHEHVAGLLARLRKDTHRG 672



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 59/193 (30%), Positives = 98/193 (50%), Gaps = 4/193 (2%)

Query: 409 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 468
           L+ A   G++++ +LL+  G+++++      + +  AA  GHV+    L E    L+  +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442

Query: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
             G   L  AAR GH ++  LL + G+N N Q +E +ET L  A   G+  VA  L +AG
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE-EETPLHCAAWHGYYSVAKALCEAG 501

Query: 529 ADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
            ++ +      TPL+ AS  G+ ++V+ L   GA+++A    G  AL  A      +V  
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561

Query: 586 VLLQAGADLDKQE 598
            LL  G  +D Q+
Sbjct: 562 TLLSQGCFVDYQD 574



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 7/110 (6%)

Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVK 552
           ++N   +      L  A CG   ++   LIK G+ I++   G S  +  A++ GH++ +K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNI-QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLK 429

Query: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD---LDKQED 599
           +L  +   +     +G+ AL  A   GH DVA +L   G++    DK+E+
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.366 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,807,073
Number of Sequences: 37866
Number of extensions: 1182813
Number of successful extensions: 18526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 499
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 6963
Number of HSP's gapped (non-prelim): 4682
length of query: 627
length of database: 18,247,518
effective HSP length: 108
effective length of query: 519
effective length of database: 14,157,990
effective search space: 7347996810
effective search space used: 7347996810
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.