Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 46519151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
(616 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 1209 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 1201 0.0
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 1138 0.0
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 1138 0.0
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 887 0.0
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 887 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 203 4e-52
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 185 1e-46
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 182 1e-45
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 182 1e-45
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 182 1e-45
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 182 1e-45
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 182 1e-45
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 177 3e-44
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 172 8e-43
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 172 8e-43
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 169 5e-42
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 167 2e-41
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 167 3e-41
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 159 5e-39
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 154 2e-37
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 148 1e-35
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 148 2e-35
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 146 5e-35
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 143 4e-34
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 142 7e-34
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 142 7e-34
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 142 7e-34
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 140 3e-33
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 127 2e-29
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 1209 bits (3129), Expect = 0.0
Identities = 616/616 (100%), Positives = 616/616 (100%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT 180
TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALT 180
Query: 181 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 240
RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY
Sbjct: 181 RMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYY 240
Query: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY
Sbjct: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTY 300
Query: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360
ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF
Sbjct: 301 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 360
Query: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV
Sbjct: 361 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
Query: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL
Sbjct: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
Query: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV 540
AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV
Sbjct: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELV 540
Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK 600
KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK
Sbjct: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAK 600
Query: 601 HQVRVAFDACKLLRKE 616
HQVRVAFDACKLLRKE
Sbjct: 601 HQVRVAFDACKLLRKE 616
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 1201 bits (3107), Expect = 0.0
Identities = 616/627 (98%), Positives = 616/627 (98%), Gaps = 11/627 (1%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
TSEIFLSSTAEGADLRTVDPETQARLEALLEAA AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 589
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDM 600
Query: 590 KTILEGIDPAKHQVRVAFDACKLLRKE 616
KTILEGIDPAKHQVRVAFDACKLLRKE
Sbjct: 601 KTILEGIDPAKHQVRVAFDACKLLRKE 627
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 1138 bits (2943), Expect = 0.0
Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
TSEIFLSSTAEGADLRTVDPETQARLEALLEAA AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
Query: 589 MKTILEGIDPAKHQVRVAF 607
+T L A H V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619
Score = 248 bits (632), Expect = 2e-65
Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
L EA S G V R LLD G +N H+ E ES L LAC G+ ++ + LL A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GAN+E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
FL++AGAD E T LMEA +GH+E+ + LL SGA V+ + ++ LT A
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
++LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Query: 553 TTAT 556
T
Sbjct: 697 VPTT 700
Score = 204 bits (518), Expect = 3e-52
Identities = 142/443 (32%), Positives = 227/443 (51%), Gaps = 23/443 (5%)
Query: 91 GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
G++G++ E+ +V +Q+ + P + T + L +G + T L+
Sbjct: 942 GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
Query: 149 LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196
L+ A + P + + C E+ + T A S H DT
Sbjct: 999 LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L AC+ G V L+ + ++G + L LA +AG+ + ++LL ++E +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
+ TPL A SGG ++V LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
GA I ++ G +PLM AA GHV ++LLD G+ IN + +ALTLAC++G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AA GH + LLI RGA+++ N +G TPL A+ GH ++V LL+ GA+++A +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADN 1356
Query: 493 TQETALTLACCGGFSEVADFLIK 515
+ T L A G +V +L+K
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379
Score = 191 bits (486), Expect = 1e-48
Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)
Query: 284 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343
D D +++S +TALT ACAGG ++V VL+ A IE ++ G TPL+ AA+AGHV V
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 344 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
+LLD G I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 404 DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460
G+V + ++LL++GA++N S SPL LAA GHV LL++ G+++ ++
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 521 EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
T L A+ +GH + + L+ GA++ G+T L A GH DV +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 576 LLQAGADLDKQEDMK 590
L+QAGAD+D ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358
Score = 168 bits (425), Expect = 2e-41
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
AL+EA EV R L S +C AAL + N
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
A++E G TPLM AS G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
VLL GA++E +E G TPLM+AA AGH+ + L+ GA +N + + ++LAC
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/135 (31%), Positives = 63/135 (46%)
Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
L++ ANV D T + A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
Query: 306 FVDIVKVLLNEGANI 320
++V LL+ N+
Sbjct: 680 HTNVVSYLLDYPNNV 694
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 1138 bits (2943), Expect = 0.0
Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
TSEIFLSSTAEGADLRTVDPETQARLEALLEAA AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
Query: 589 MKTILEGIDPAKHQVRVAF 607
+T L A H V F
Sbjct: 601 GRTPLMKAARAGHLCTVQF 619
Score = 248 bits (632), Expect = 2e-65
Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
L EA S G V R LLD G +N H+ E ES L LAC G+ ++ + LL A+ E +
Sbjct: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GAN+E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G ++
Sbjct: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
FL++AGAD E T LMEA +GH+E+ + LL SGA V+ + ++ LT A
Sbjct: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
++LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL NV +
Sbjct: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
Query: 553 TTAT 556
T
Sbjct: 697 VPTT 700
Score = 204 bits (518), Expect = 3e-52
Identities = 142/443 (32%), Positives = 227/443 (51%), Gaps = 23/443 (5%)
Query: 91 GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
G++G++ E+ +V +Q+ + P + T + L +G + T L+
Sbjct: 942 GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
Query: 149 LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196
L+ A + P + + C E+ + T A S H DT
Sbjct: 999 LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L AC+ G V L+ + ++G + L LA +AG+ + ++LL ++E +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
+ TPL A SGG ++V LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
GA I ++ G +PLM AA GHV ++LLD G+ IN + +ALTLAC++G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AA GH + LLI RGA+++ N +G TPL A+ GH ++V LL+ GA+++A +
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA-ADN 1356
Query: 493 TQETALTLACCGGFSEVADFLIK 515
+ T L A G +V +L+K
Sbjct: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379
Score = 191 bits (486), Expect = 1e-48
Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)
Query: 284 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343
D D +++S +TALT ACAGG ++V VL+ A IE ++ G TPL+ AA+AGHV V
Sbjct: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 344 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
+LLD G I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Query: 404 DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460
G+V + ++LL++GA++N S SPL LAA GHV LL++ G+++ ++
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 521 EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
T L A+ +GH + + L+ GA++ G+T L A GH DV +
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 576 LLQAGADLDKQEDMK 590
L+QAGAD+D ++ K
Sbjct: 1344 LVQAGADVDAADNRK 1358
Score = 168 bits (425), Expect = 2e-41
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
AL+EA EV R L S +C AAL + N
Sbjct: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
A++E G TPLM AS G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
VLL GA++E +E G TPLM+AA AGH+ + L+ GA +N + + ++LAC
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 69.7 bits (169), Expect = 7e-12
Identities = 43/135 (31%), Positives = 63/135 (46%)
Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
L++ ANV D T + A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
Query: 306 FVDIVKVLLNEGANI 320
++V LL+ N+
Sbjct: 680 HTNVVSYLLDYPNNV 694
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 887 bits (2293), Expect = 0.0
Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)
Query: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
Query: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202
AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
Query: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607
YACENGHTDVADVLLQAGADL+ + E +T L A H V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
Score = 246 bits (628), Expect = 4e-65
Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
L EA S G V R LL+ G +N H+ E ES L LAC G+ E+ + LL A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GA++E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
FL++AGAD E T LMEA +GH+E+ + LL +GA V+ + ++ LT A
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
L+LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
Query: 553 TTATGDTALT 562
T LT
Sbjct: 726 APPPDVTQLT 735
Score = 207 bits (526), Expect = 3e-53
Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L AC+ G V+ LL+ G S+ ++G + L LA +AG+ + ++LL A++E +
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
+ TPL A SGG ++V+LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
Query: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
GA I ++ G +PLM AA GH ++LLD G+ IN + +ALTLAC++G
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1325
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AA GH + LLI RGA+++ N +G TPL AA GH ++V LL+ GA+++A
Sbjct: 1326 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1385
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
TPLM A ++GH+++V+YL+
Sbjct: 1386 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1406
Score = 198 bits (503), Expect = 1e-50
Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)
Query: 286 DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
D+++Q+ + + TALT ACAGG ++V+ LL GA+IE ++ G TPL+ AA+AGHV V
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
+LLD+GA I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193
Query: 405 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461
G+V + ++LL++GA++N S SPL LAA GH LL++ G+++ ++
Sbjct: 1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1253
Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
Query: 522 L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
T L A+ +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Query: 577 LQAGADLDKQEDMK 590
+QAGAD+D ++ K
Sbjct: 1373 VQAGADVDAADNRK 1386
Score = 173 bits (439), Expect = 4e-43
Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T L A +GG+ ++V+ LL A + + G T L A G V +V++LL+ GA+IE
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 323 HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
+E TPL A S G EV +LL GA H N + L+LA G++++++ LL
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 382 EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438
AGA+ +T + LM A M+GH +LLLD G+ +N + + + LTLA G
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1263
Query: 439 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497
E+ +LL++R AN+E G TPLMEAA G+ E+ +LL +GA++NA +++TA
Sbjct: 1264 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1323
Query: 498 LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
LT+A G + + LI GA I++ +TPL A+ GHL++V+ L+ +GA+V A
Sbjct: 1324 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383
Query: 555 ATGDTALTYACENGHTDVADVLLQ 578
T L A GH V L++
Sbjct: 1384 NRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 167 bits (422), Expect = 3e-41
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
AL+EA EV R L S +C AAL + +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
A++E G TPLM A+ G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
VLL GA++E +E G TPLM+AA AGHV + L+ GA +N + + L+LAC
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/135 (32%), Positives = 62/135 (45%)
Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
L++ ANV D T L A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
Query: 306 FVDIVKVLLNEGANI 320
+V LL+ N+
Sbjct: 709 HTSVVCYLLDYPNNL 723
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 887 bits (2293), Expect = 0.0
Identities = 468/586 (79%), Positives = 505/586 (86%), Gaps = 35/586 (5%)
Query: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
Query: 154 -----------AFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 202
AFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 503 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
Query: 563 YACENGHTDVADVLLQAGADLD-KQEDMKTILEGIDPAKHQVRVAF 607
YACENGHTDVADVLLQAGADL+ + E +T L A H V F
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
Score = 246 bits (628), Expect = 4e-65
Identities = 150/370 (40%), Positives = 219/370 (59%), Gaps = 10/370 (2%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
L EA S G V R LL+ G +N H+ E ES L LAC G+ E+ + LL A+ E +
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHK 430
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 431 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 489
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GA++E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G L++
Sbjct: 490 GASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEV 549
Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
FL++AGAD E T LMEA +GH+E+ + LL +GA V+ + ++ LT A
Sbjct: 550 ADFLIKAGADIELGCS---TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACE 606
Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 607 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHT 666
Query: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
L+LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL N+ +
Sbjct: 667 VLSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTSVVCYLLDYPNNLLS 725
Query: 553 TTATGDTALT 562
T LT
Sbjct: 726 APPPDVTQLT 735
Score = 207 bits (526), Expect = 3e-53
Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L AC+ G V+ LL+ G S+ ++G + L LA +AG+ + ++LL A++E +
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
+ TPL A SGG ++V+LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 895 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
Query: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
GA I ++ G +PLM AA GH ++LLD G+ IN + +ALTLAC++G
Sbjct: 955 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AA GH + LLI RGA+++ N +G TPL AA GH ++V LL+ GA+++A
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
TPLM A ++GH+++V+YL+
Sbjct: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
Score = 198 bits (503), Expect = 1e-50
Identities = 118/314 (37%), Positives = 182/314 (57%), Gaps = 10/314 (3%)
Query: 286 DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
D+++Q+ + + TALT ACAGG ++V+ LL GA+IE ++ G TPL+ AA+AGHV V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
+LLD+GA I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
Query: 405 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 461
G+V + ++LL++GA++N S SPL LAA GH LL++ G+++ ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
Query: 522 L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
T L A+ +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Query: 577 LQAGADLDKQEDMK 590
+QAGAD+D ++ K
Sbjct: 1122 VQAGADVDAADNRK 1135
Score = 173 bits (439), Expect = 4e-43
Identities = 118/324 (36%), Positives = 179/324 (55%), Gaps = 9/324 (2%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T L A +GG+ ++V+ LL A + + G T L A G V +V++LL+ GA+IE
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 323 HNE-NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 381
+E TPL A S G EV +LL GA H N + L+LA G++++++ LL
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILL 952
Query: 382 EAGADQEHKTDEM--HTALMEACMDGHVEVARLLLDSGAQVNMPAD-SFESPLTLAACGG 438
AGA+ +T + LM A M+GH +LLLD G+ +N + + + LTLA G
Sbjct: 953 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQG 1012
Query: 439 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA-QTEETQETA 497
E+ +LL++R AN+E G TPLMEAA G+ E+ +LL +GA++NA +++TA
Sbjct: 1013 RTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1072
Query: 498 LTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATT 554
LT+A G + + LI GA I++ +TPL A+ GHL++V+ L+ +GA+V A
Sbjct: 1073 LTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1132
Query: 555 ATGDTALTYACENGHTDVADVLLQ 578
T L A GH V L++
Sbjct: 1133 NRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 167 bits (422), Expect = 3e-41
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
AL+EA EV R L S +C AAL + +
Sbjct: 437 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 497 NDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKA 556
Query: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
A++E G TPLM A+ G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 557 GADIE----LGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDV 612
Query: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
VLL GA++E +E G TPLM+AA AGHV + L+ GA +N + + L+LAC
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 68.9 bits (167), Expect = 1e-11
Identities = 44/135 (32%), Positives = 62/135 (45%)
Query: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 589 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQF 648
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
L++ ANV D T L A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 649 LISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 708
Query: 306 FVDIVKVLLNEGANI 320
+V LL+ N+
Sbjct: 709 HTSVVCYLLDYPNNL 723
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 203 bits (516), Expect = 4e-52
Identities = 146/462 (31%), Positives = 234/462 (50%), Gaps = 20/462 (4%)
Query: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRM 182
+I L+ GA++ D E + AL+ AA E++ L LD A +
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRT---ALIAAAYMGHREIVEHL-------LDHGA----EV 703
Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
E+ + +L S G + V L+D G V+ ++G + L +A G+ ++
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
+LL A+V+ N G TPL+AA+S G+ +V LL A V+S + G T L+ A
Sbjct: 764 VDLLLEGGADVDHTDNNGR-TPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
A G V++V+ LL+ G + ++ G TPL AA GH + L++ GA N N+ +
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
+ LA +GH D V+ LLE ++ + + + AL A ++GH ++ LL GA VN
Sbjct: 883 PFI-LASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNC 941
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
L + A + +A +E GAN+E + EG T L + +GH EMV +L+A
Sbjct: 942 KDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAY 1001
Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539
A++NA E + +AL A G +V LI+ GA ++ C+ T L A+QEGH+++
Sbjct: 1002 HADVNAADNE-KRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDV 1060
Query: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
V+ LL GA+ + G TA+ A +NGH+ + +L + GA
Sbjct: 1061 VQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 196 bits (498), Expect = 5e-50
Identities = 133/434 (30%), Positives = 211/434 (48%), Gaps = 41/434 (9%)
Query: 189 NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
+ D+R+ A + G + V LL G VN+ EG + L A G+ E+ + LL
Sbjct: 638 DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
Query: 248 AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
A V G + L +S G+ +V LL+ A+V+ G T L A
Sbjct: 698 DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
Query: 304 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
G VD+V +LL GA+++ + NG TPL+ AAS GH V LL GA +++ +E + +
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816
Query: 364 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 423
L++A +G++++VR LL+ G D+ H+ D T L A +GH + L++ GA+ N
Sbjct: 817 VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
Query: 424 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483
+ P LA+ GH + +L+E +N+++ +G L AA EGH ++V LL + G
Sbjct: 877 DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
Query: 484 ANINAQTEETQ--------------------------------ETALTLACCGGFSEVAD 511
A++N + + + TAL ++C G E+
Sbjct: 937 ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
Query: 512 FLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 568
LI AD+ + + L A+ +GH+++V+ L+ GA V T G TAL A + G
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056
Query: 569 HTDVADVLLQAGAD 582
H DV VLL+ GAD
Sbjct: 1057 HIDVVQVLLEHGAD 1070
Score = 196 bits (497), Expect = 7e-50
Identities = 155/532 (29%), Positives = 237/532 (44%), Gaps = 81/532 (15%)
Query: 135 LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVD 194
L T+ P+ Q L+ L++A A + E R + V AL+ + T + +N + Q D
Sbjct: 486 LSTLIPKEQEVLQLLVKAGAHVNSED-DRTSCIVRQALEREDSIRTLL--DNGASVNQCD 542
Query: 195 TRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHA 251
+ LA A G ++ V L+ G + G + L LA G+ ++ L+ A
Sbjct: 543 SNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGA 602
Query: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
N+ G T L +A+ GG+ ++V LL V+ A TAL A GG DIV
Sbjct: 603 NINHTDQDG-WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVL 661
Query: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN----------------- 354
LL GA + + G T L+ AA GH E+ LLDHGA +N
Sbjct: 662 NLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCV 721
Query: 355 --------------------THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394
H ++ + L +A Y+GH+D+V LLE GAD +H +
Sbjct: 722 PASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNG 781
Query: 395 HTALMEACMDGH---------------------------------VEVARLLLDSGAQVN 421
T L+ A GH VEV R LLD G N
Sbjct: 782 RTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 422 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 481
D+ +PL +AA GH + LIE+GA E++++G P + A++EGH + V +LL
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Query: 482 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLE 538
+NI+ + + + AL +A G ++ + L GAD+ + L + E L
Sbjct: 902 NKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 539 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
+ +Y L +GANV A+ A G TAL +C GH ++ VL+ AD++ ++ K
Sbjct: 961 MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEK 1012
Score = 157 bits (397), Expect = 3e-38
Identities = 109/339 (32%), Positives = 169/339 (49%), Gaps = 12/339 (3%)
Query: 275 DIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEA 334
++++LL+ A VNS+ + + A D ++ LL+ GA++ + NG T L A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 335 ASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM 394
A +G ++V +L+ GA + + + LTLA +GH +V L+ GA+ H +
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 395 HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLE 454
TAL A GH EV LL +G +V+ + L AA GGH ++ L++ GA +
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 455 EVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC----GGFSEVA 510
+ ++EG T L+ AA GH E+V LL GA +N + + + A C G + V
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
Query: 511 DFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
LI GA+++ C TPL+ A+ EGH+++V LL GA+V T G T L A
Sbjct: 732 SLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAAS 790
Query: 567 NGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRV 605
GH V + LL GA +D + + I A+ V V
Sbjct: 791 MGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
Score = 155 bits (393), Expect = 8e-38
Identities = 114/364 (31%), Positives = 176/364 (48%), Gaps = 6/364 (1%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L A S G + V LL G +V+ EG ++L +A + G E+ + LL + R
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
+ G TPL A+ G+ I + L+ A N G A G D V++LL
Sbjct: 845 DAG-WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENK 903
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
+NI+ +G L AA GH ++ +L HGA +N + + + LA + L M
Sbjct: 904 SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILAL-ENQLTMA 962
Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
+ LE GA+ E E TAL +C GH+E+ ++L+ A VN + S L AA
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
GHV++ LLIE GA ++ ++G T L AA+EGH ++V +LL GA+ N ++ TA
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPN-HADQFGRTA 1081
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS---GANVHATT 554
+ +A G S++ L K GA GCS + ++ L+ + + S +N +T
Sbjct: 1082 MRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST 1141
Query: 555 ATGD 558
GD
Sbjct: 1142 GGGD 1145
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 185 bits (469), Expect = 1e-46
Identities = 132/395 (33%), Positives = 200/395 (50%), Gaps = 12/395 (3%)
Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
D L A G+ N V+ LLD G ++ T +G + L +G+ ++ ++LL A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
+ G ++PL A+ G +L+ V+LLL H+ V+ + TAL A G + KVL
Sbjct: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 370
L++ AN NG TPL A ++V +LL HGA I + ES LT +A +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
Query: 371 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 430
GH+++V L+ GA TAL A G EV R L+ GAQV A ++P
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
L ++A G ++ L+++GA+ GYTPL +AREGHE++ A LL GA+++ T
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
++ T L +A G EVA+ L++ A + TPL A+ + ++ LL G
Sbjct: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
A+ HA G T L A + D+A LL+ GAD
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGAD 656
Score = 181 bits (459), Expect = 2e-45
Identities = 136/427 (31%), Positives = 216/427 (50%), Gaps = 19/427 (4%)
Query: 168 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 225
V LD AA L++ K S H A Q D +N V+ LL V++ T
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
Query: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 285
+ + L +A G+Y++A+VLL AN + G TPL A + +++LLL H A
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
Query: 286 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 345
+ + + +G T + A G V+IV L++ GA+ N G T L AA +G EV R
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 346 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 405
L+ GA + + + ++ L ++ G D+V+ LL+ GA T +T L + +G
Sbjct: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 406 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
H +VA LLD GA +++ +PL +AA G +E+A LL+++ A+ + G TPL
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
Query: 466 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 525
AA ++++ LLL QGA+ +A + T L +A ++A L++ GAD
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 526 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
+ A+QEGH+++V LL ANV+ + +G T L A + +VA+VL+ GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
Query: 583 LDKQEDM 589
+D Q M
Sbjct: 723 VDAQTKM 729
Score = 171 bits (432), Expect = 2e-42
Identities = 133/426 (31%), Positives = 208/426 (48%), Gaps = 7/426 (1%)
Query: 159 EVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR 218
+ L L + C + A L KA + A T L AC + + LL G
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFT-PLHIACKKNRIKVMELLLKHGA 424
Query: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
S+ TE G + + +A G+ + L+ A+ +G+ MAA SG ++V+
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVR 483
Query: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
L+ A V +++ T L + G DIV+ LL +GA+ +G+TPL +A G
Sbjct: 484 YLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398
H +VA LLDHGA ++ + + + L +A G L++ LL+ A + T L
Sbjct: 544 HEDVAAFLLDHGASLSITTKK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL 602
Query: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458
A + +VA LLLD GA + A + +PL +AA +++A L+E GA+ V
Sbjct: 603 HVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
+G + AA+EGH +MV+LLL + AN+N + ++ T L LA VA+ L+ GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Query: 519 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
++ TPL G++++V +LL A V+A T G T L A + GHT + +V
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINV 781
Query: 576 LLQAGA 581
LLQ A
Sbjct: 782 LLQNNA 787
Score = 170 bits (431), Expect = 3e-42
Identities = 124/378 (32%), Positives = 188/378 (49%), Gaps = 12/378 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G VN V +L+ G S N GE+ L +A +G E+ + L+ A VE + K D TP
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA-KDDQTP 502
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L ++ G DIV+ LL A N+ + +G T L + G D+ LL+ GA++
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD---MVRFLL 381
+ G TPL AA G +EVA +LL A + +S LT H D + LL
Sbjct: 563 KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAG----KSGLTPLHVAAHYDNQKVALLLL 618
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA +T L A +++A LL+ GA N + + LAA GHV+
Sbjct: 619 DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVD 678
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ +LL+ R AN+ N G TPL AA+E + +L+ QGA+++AQT+ T L +
Sbjct: 679 MVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY-TPLHVG 737
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
C G ++ +FL++ A + TPL +A+Q+GH ++ LL + A+ + T G+
Sbjct: 738 CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGN 797
Query: 559 TALTYACENGHTDVADVL 576
TAL A G+ V D L
Sbjct: 798 TALGIARRLGYISVVDTL 815
Score = 164 bits (415), Expect = 2e-40
Identities = 119/391 (30%), Positives = 195/391 (49%), Gaps = 6/391 (1%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L A G + LLD+ + N G + L +AC ++ ++LL A+++
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
G +TP+ A+ G+++IV L+ H A N+ + G TAL A G ++V+ L+ +
Sbjct: 430 TESG-LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GA +E ++ TPL +A G ++ + LL GA N + + L L+ +GH D+
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS-GYTPLHLSAREGHEDV 547
Query: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
FLL+ GA T + T L A G +EVA LLL A + S +PL +AA
Sbjct: 548 AAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAH 607
Query: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
+ ++A LL+++GA+ GYTPL AA++ ++ LL GA+ NA T +
Sbjct: 608 YDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGI-A 666
Query: 497 ALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHAT 553
++ LA G ++ L+ A++ L TPL A+QE + + + L+ GA+V A
Sbjct: 667 SVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQ 726
Query: 554 TATGDTALTYACENGHTDVADVLLQAGADLD 584
T G T L C G+ + + LLQ A ++
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
Score = 155 bits (393), Expect = 8e-38
Identities = 125/429 (29%), Positives = 203/429 (47%), Gaps = 36/429 (8%)
Query: 187 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 246
+H A Q+ E ++ + RK R + ++ S L A AG+ E A
Sbjct: 2 AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
Query: 247 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 306
+ ++ + N+ + L AS G++++V LL +A+V++ + GNTAL A G
Sbjct: 61 IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
Query: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366
++VKVL+ GAN+ ++NG TPL AA H+EV + LLD+GA + + E + L
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
Query: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMH-----------------------------TA 397
+A +GH +V LLE + + +H T
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTP 238
Query: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
L A G++ VA LLL+ A V+ A + +PL +A+ G+ + LL++RGA ++
Sbjct: 239 LHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKT 298
Query: 458 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 517
+G TPL AR GHE++V +LL + A I ++T+ + L +A G L++
Sbjct: 299 RDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL-SPLHMATQGDHLNCVQLLLQHN 357
Query: 518 A---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
D+ T L A+ GH ++ K LL AN +A G T L AC+ V +
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417
Query: 575 VLLQAGADL 583
+LL+ GA +
Sbjct: 418 LLLKHGASI 426
Score = 138 bits (347), Expect = 2e-32
Identities = 107/337 (31%), Positives = 168/337 (49%), Gaps = 16/337 (4%)
Query: 255 DRGNKGDITP-LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
DR K D + A+ G+L+ + + D+N + G AL A G V++V L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKG 372
L AN++ + G+T L A+ AG EV +VL+ +GA +N S N F + L +A +
Sbjct: 94 LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF--TPLYMAAQEN 151
Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPADSFESP 430
HL++V+FLL+ GA Q T++ T L A GH +V LLL D+ +V +PA
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPA------ 205
Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
L +AA + AALL++ N + + G+TPL AA G+ + LLL + A ++ T
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF-T 264
Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
T L +A G + + L+ GA I+ TPL ++ GH ++V+ LL
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
A + + T G + L A + H + +LLQ +D
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/93 (39%), Positives = 50/93 (53%), Gaps = 6/93 (6%)
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHAT 553
L A G + D+ IK G DI + C+ L AS+EGH+E+V LL ANV A
Sbjct: 46 LRAARAGHLEKALDY-IKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103
Query: 554 TATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
T G+TAL A G +V VL+ GA+++ Q
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQ 136
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 182 bits (461), Expect = 1e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 576
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
T L A + +VA LLQ G + + ++G+ P
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 671
Score = 178 bits (451), Expect = 1e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 506
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 622
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 623 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 682
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 683 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 741
Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
Query: 558 DTALTYACENGHTDVADVL 576
T L A G+ V DVL
Sbjct: 801 TTPLAIAKRLGYISVTDVL 819
Score = 177 bits (450), Expect = 2e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 587 EDMKTIL 593
+D +T L
Sbjct: 501 KDDQTPL 507
Score = 173 bits (438), Expect = 5e-43
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 471 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 588
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 707
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
Query: 558 DTALTYACENGHTDVADVLLQAGA 581
+ L A + GHTD+ +LL+ GA
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGA 791
Score = 170 bits (431), Expect = 3e-42
Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)
Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
NA + T L +A EVA L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714
Query: 571 DVADVLLQAGADLD 584
VADVL++ G +D
Sbjct: 715 PVADVLIKHGVMVD 728
Score = 162 bits (409), Expect = 1e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 440
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 559
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 678
Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 679 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 738
Query: 562 TYACENGHTDVADVLLQAGADLD 584
A G+ + LLQ AD++
Sbjct: 739 HVASHYGNIKLVKFLLQHQADVN 761
Score = 150 bits (380), Expect = 3e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
L+ G + + +H T L A ++
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Score = 140 bits (354), Expect = 3e-33
Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 14/336 (4%)
Query: 255 DRGNKGDI-TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
DR K D T + A+ G LD L + D+N+ + G L A G V +V L
Sbjct: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
L++ +E + G+T L AA AG EV R L+++GA +N S + + L +A + H
Sbjct: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENH 156
Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPL 431
L++V+FLLE GA+Q T++ T L A GH V L++ G +V +PA L
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------L 210
Query: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTE 491
+AA AA+L++ N + ++ G+TPL AA + + LLL +GA++N T
Sbjct: 211 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TP 269
Query: 492 ETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA 548
+ T L +A G + L+ GA IE TPL A++ GH+ + + LL GA
Sbjct: 270 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
Query: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
+ A T G + + A + H D +LLQ A++D
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 182 bits (461), Expect = 1e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
T L A + +VA LLQ G + + ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
Score = 178 bits (451), Expect = 1e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 558 DTALTYACENGHTDVADVL 576
T L A G+ V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786
Score = 177 bits (450), Expect = 2e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 587 EDMKTIL 593
+D +T L
Sbjct: 468 KDDQTPL 474
Score = 173 bits (438), Expect = 5e-43
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 558 DTALTYACENGHTDVADVLLQAGA 581
+ L A + GHTD+ +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 170 bits (431), Expect = 3e-42
Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)
Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 571 DVADVLLQAGADLD 584
VADVL++ G +D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 162 bits (409), Expect = 1e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Query: 562 TYACENGHTDVADVLLQAGADLD 584
A G+ + LLQ AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728
Score = 150 bits (380), Expect = 3e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 138 bits (347), Expect = 2e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
+ + A + H D +LLQ A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 182 bits (461), Expect = 1e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
T L A + +VA LLQ G + + ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
Score = 178 bits (451), Expect = 1e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 558 DTALTYACENGHTDVADVL 576
T L A G+ V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786
Score = 177 bits (450), Expect = 2e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 587 EDMKTIL 593
+D +T L
Sbjct: 468 KDDQTPL 474
Score = 173 bits (438), Expect = 5e-43
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 558 DTALTYACENGHTDVADVLLQAGA 581
+ L A + GHTD+ +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 170 bits (431), Expect = 3e-42
Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)
Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 571 DVADVLLQAGADLD 584
VADVL++ G +D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 162 bits (409), Expect = 1e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Query: 562 TYACENGHTDVADVLLQAGADLD 584
A G+ + LLQ AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728
Score = 150 bits (380), Expect = 3e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 138 bits (347), Expect = 2e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
+ + A + H D +LLQ A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 182 bits (461), Expect = 1e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
T L A + +VA LLQ G + + ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
Score = 178 bits (451), Expect = 1e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 558 DTALTYACENGHTDVADVL 576
T L A G+ V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786
Score = 177 bits (450), Expect = 2e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 587 EDMKTIL 593
+D +T L
Sbjct: 468 KDDQTPL 474
Score = 173 bits (438), Expect = 5e-43
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 558 DTALTYACENGHTDVADVLLQAGA 581
+ L A + GHTD+ +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 170 bits (431), Expect = 3e-42
Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)
Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 571 DVADVLLQAGADLD 584
VADVL++ G +D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 162 bits (409), Expect = 1e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Query: 562 TYACENGHTDVADVLLQAGADLD 584
A G+ + LLQ AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728
Score = 150 bits (380), Expect = 3e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 138 bits (347), Expect = 2e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
+ + A + H D +LLQ A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 182 bits (461), Expect = 1e-45
Identities = 136/400 (34%), Positives = 201/400 (50%), Gaps = 17/400 (4%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 502 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 559 TALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDP 598
T L A + +VA LLQ G + + ++G+ P
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAES-----VQGVTP 638
Score = 178 bits (451), Expect = 1e-44
Identities = 135/379 (35%), Positives = 196/379 (51%), Gaps = 14/379 (3%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + V+ LL G S N + E+ L +A AG+ E+A+ LL A V + K D TP
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA-KDDQTP 473
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ ++VKLLL ++A+ N + G+T L A G V+ V LL + A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 381
+ G TPL AA G V VA +LL+ A H N ++ LT +A + +LD+V+ LL
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDA----HPNAAGKNGLTPLHVAVHHNNLDIVKLLL 589
Query: 382 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 441
G +T L A VEVAR LL G N + +PL LAA GH E
Sbjct: 590 PRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAE 649
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ ALL+ + AN N G TPL A+EGH + +L+ G ++A T T L +A
Sbjct: 650 MVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDA-TTRMGYTPLHVA 708
Query: 502 CCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATG 557
G ++ FL++ AD+ +LG S PL +A+Q+GH ++V LL +GA+ + ++ G
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYS-PLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 558 DTALTYACENGHTDVADVL 576
T L A G+ V DVL
Sbjct: 768 TTPLAIAKRLGYISVTDVL 786
Score = 177 bits (450), Expect = 2e-44
Identities = 140/427 (32%), Positives = 214/427 (50%), Gaps = 38/427 (8%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 318
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 319 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 352 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 410
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 527
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQ 586
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A ++ K
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 587 EDMKTIL 593
+D +T L
Sbjct: 468 KDDQTPL 474
Score = 173 bits (438), Expect = 5e-43
Identities = 133/384 (34%), Positives = 193/384 (50%), Gaps = 6/384 (1%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
AC V + LL G S++ TE G + L +A G+ + + LL A+ K
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
+ TPL A+ G+ ++ K LL + A VN+++ T L A G ++VK+LL AN
Sbjct: 438 E-TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 380
GHTPL AA GHVE LL+ A + + + L +A G + + L
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVAAKYGKVRVAELL 555
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 440
LE A T L A ++++ +LLL G + PA + +PL +AA V
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
E+A L++ G + + +G TPL AA+EGH EMVALLL++ AN N + T L L
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL-TPLHL 674
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
G VAD LIK G ++ TPL AS G+++LVK+LL A+V+A T G
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 558 DTALTYACENGHTDVADVLLQAGA 581
+ L A + GHTD+ +LL+ GA
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGA 758
Score = 170 bits (431), Expect = 3e-42
Identities = 132/434 (30%), Positives = 204/434 (47%), Gaps = 43/434 (9%)
Query: 192 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 306 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 426 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 485
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 486 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 513
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 514 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 571 DVADVLLQAGADLD 584
VADVL++ G +D
Sbjct: 682 PVADVLIKHGVMVD 695
Score = 162 bits (409), Expect = 1e-39
Identities = 123/383 (32%), Positives = 183/383 (47%), Gaps = 6/383 (1%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + LLD+G N G + L +AC + + ++LL A++ D + +TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-DAVTESGLTP 407
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L AS G+L IVK LL A N + T L A G ++ K LL A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++ TPL AA GH + ++LL++ A N + + L +A +GH++ V LLE
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA-GHTPLHIAAREGHVETVLALLEKE 526
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
A Q T + T L A G V VA LLL+ A N + +PL +A ++++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
LL+ RG + GYTPL AA++ E+ LL G + NA++ + T L LA
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGV-TPLHLAAQE 645
Query: 505 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
G +E+ L+ A+ LG TPL +QEGH+ + L+ G V ATT G T L
Sbjct: 646 GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL 705
Query: 562 TYACENGHTDVADVLLQAGADLD 584
A G+ + LLQ AD++
Sbjct: 706 HVASHYGNIKLVKFLLQHQADVN 728
Score = 150 bits (380), Expect = 3e-36
Identities = 112/359 (31%), Positives = 175/359 (48%), Gaps = 34/359 (9%)
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 378 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 408
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 409 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 468
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 469 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 525
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA +D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Score = 138 bits (347), Expect = 2e-32
Identities = 106/327 (32%), Positives = 165/327 (50%), Gaps = 13/327 (3%)
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
T + A+ G LD L + D+N+ + G L A G V +V LL++ +E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
+ G+T L AA AG EV R L+++GA +N S + + L +A + HL++V+FLLE
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQENHLEVVKFLLE 132
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPADSFESPLTLAACGGHV 440
GA+Q T++ T L A GH V L++ G +V +PA L +AA
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPA------LHIAARNDDT 186
Query: 441 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 500
AA+L++ N + ++ G+TPL AA + + LLL +GA++N T + T L +
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNF-TPQNGITPLHI 245
Query: 501 ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATG 557
A G + L+ GA IE TPL A++ GH+ + + LL GA + A T G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 558 DTALTYACENGHTDVADVLLQAGADLD 584
+ + A + H D +LLQ A++D
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEID 332
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 177 bits (448), Expect = 3e-44
Identities = 142/424 (33%), Positives = 212/424 (50%), Gaps = 45/424 (10%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L A G + LLD+ + N G + L +AC ++ ++L+ A+++
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
G +TP+ A+ G+L+IV LLL + A + + G TAL A G V++V+ LL
Sbjct: 407 TESG-LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRN 465
Query: 317 GANIEDH---------------------------------NENGHTPLMEAASAGHVEVA 343
GA ++ NG+TPL +A G V+VA
Sbjct: 466 GALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
Query: 344 RVLLDHGAGINTHSNEFKE--SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
VLL+ GA HS K+ + L +A G LD+ + LL+ A + T L A
Sbjct: 526 SVLLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582
Query: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
+ +VA LLL+ GA + A + +PL +AA +++A+ L+ GA V +G
Sbjct: 583 AHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV 642
Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD-- 519
TPL A++EGH +MV LLL +GANI+ T ++ T+L LA VAD L K GAD
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 520 --IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 577
+LG TPL+ A G++++V +LL GANV+A T G T L A + GHT + +VLL
Sbjct: 702 AHTKLG-YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 578 QAGA 581
Q GA
Sbjct: 761 QHGA 764
Score = 173 bits (438), Expect = 5e-43
Identities = 135/416 (32%), Positives = 204/416 (49%), Gaps = 24/416 (5%)
Query: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
Query: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
Query: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
Query: 359 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 410
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 411 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 470
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 527
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 403
Score = 169 bits (429), Expect = 5e-42
Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)
Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 37 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96
Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 97 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
V +LL + DHN E+G TP
Sbjct: 156 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 215
Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 392
Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
Query: 567 NGHTDVADVLLQAGADLD 584
G +V LL+ GA +D
Sbjct: 453 AGQVEVVRCLLRNGALVD 470
Score = 168 bits (425), Expect = 2e-41
Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A G+ N V+ LLD G ++ T +G + L A +G+ ++ ++LL A + R G
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
++PL A+ G +++ VK LL H A V+ + TAL A G + K+LL++ AN
Sbjct: 312 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
NG TPL A ++V +L+ +GA I ES LT +A + GHL++V
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 426
Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 427 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 486
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
G E+ LL++ A+ + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 545
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
L +A G +VA L++ A + TPL A+ + ++ LL GA+ HAT
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
G T L A + +A LL GA+
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAE 633
Score = 141 bits (355), Expect = 2e-33
Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)
Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
N VD R+ E A G V+ LL + T G + L ++ G ++
Sbjct: 465 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
A VLL A K TPL A+ G LD+ KLLL A +S G T L A
Sbjct: 525 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
+ +LL +GA+ +NG+TPL AA +++A LL++GA N + +
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 642
Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
+ L LA +GH DMV LL+ GA+ T T+L A + V VA +L GA +
Sbjct: 643 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 702
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
+PL +A G+V++ L+++GAN+ GYTPL +AA++GH ++ +LL
Sbjct: 703 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
GA NA T TAL +A G+ V D L K + +T + E + E +
Sbjct: 763 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 820
Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
+L T TGD Y ++ D L + LD ++ LEG
Sbjct: 821 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 872
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
K N H + + SL A + VN L G + HT+ G + L +AC G ++
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
LL ANV + K TPL A+ G+ I+ +LL H A N+ +A GNTAL A
Sbjct: 723 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
G+ VD +KV+ E E H N + E E + G G
Sbjct: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 840
Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
+ KE +L + + ++ +R+ LE G + +D HT
Sbjct: 841 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 888
Score = 51.6 bits (122), Expect = 2e-06
Identities = 35/102 (34%), Positives = 56/102 (54%), Gaps = 6/102 (5%)
Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLL 544
Q ++ + L A G +V ++L K G DI C+ L A++EGH+ LV+ LL
Sbjct: 6 QKSDSNASFLRAARAGNLDKVVEYL-KGGIDINT-CNQNGLNALHLAAKEGHVGLVQELL 63
Query: 545 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
G++V + T G+TAL A G +V VL++ GA+++ Q
Sbjct: 64 GRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 105
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 172 bits (436), Expect = 8e-43
Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
KG+ T L AS G ++VK+L+ A++N+QS G T L A +D+VK LL
Sbjct: 94 TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GAN E+G TPL A GH + +LL+ N + + AL +A K
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
Query: 377 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 545
+T+ + L +A G E L++ A D+ L T L A+ GH + K LL
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
AN +A G T L AC+ V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
Score = 169 bits (429), Expect = 5e-42
Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)
Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
V +LL + DHN E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 567 NGHTDVADVLLQAGADLD 584
G +V LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491
Score = 168 bits (425), Expect = 2e-41
Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A G+ N V+ LLD G ++ T +G + L A +G+ ++ ++LL A + R G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
++PL A+ G +++ VK LL H A V+ + TAL A G + K+LL++ AN
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
NG TPL A ++V +L+ +GA I ES LT +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
G E+ LL++ A+ + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
L +A G +VA L++ A + TPL A+ + ++ LL GA+ HAT
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
G T L A + +A LL GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Score = 141 bits (355), Expect = 2e-33
Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)
Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
N VD R+ E A G V+ LL + T G + L ++ G ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
A VLL A K TPL A+ G LD+ KLLL A +S G T L A
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
+ +LL +GA+ +NG+TPL AA +++A LL++GA N + +
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663
Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
+ L LA +GH DMV LL+ GA+ T T+L A + V VA +L GA +
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
+PL +A G+V++ L+++GAN+ GYTPL +AA++GH ++ +LL
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
GA NA T TAL +A G+ V D L K + +T + E + E +
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841
Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
+L T TGD Y ++ D L + LD ++ LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893
Score = 125 bits (314), Expect = 1e-28
Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)
Query: 326 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 385
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 496
L+E GAN ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 497 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 526
AL L A G VA L+ GA ++ T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
PL AS+ G+ +VK LL G + A T G T L A +GH V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 85.5 bits (210), Expect = 1e-16
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
K + + + + A G+++ L G +N + + L LAA GHV L L+ R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
G++++ +G T L A+ G E+V +L+ +GANINAQ++ GF
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
Query: 510 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569
TPL A+QE H+++VKYLL +GAN T G T L A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
Query: 570 TDVADVLLQ 578
+LL+
Sbjct: 176 NQAVAILLE 184
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
K N H + + SL A + VN L G + HT+ G + L +AC G ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
LL ANV + K TPL A+ G+ I+ +LL H A N+ +A GNTAL A
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
G+ VD +KV+ E E H N + E E + G G
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861
Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
+ KE +L + + ++ +R+ LE G + +D HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 172 bits (436), Expect = 8e-43
Identities = 131/398 (32%), Positives = 197/398 (49%), Gaps = 18/398 (4%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
KG+ T L AS G ++VK+L+ A++N+QS G T L A +D+VK LL
Sbjct: 94 TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
GAN E+G TPL A GH + +LL+ N + + AL +A K
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
Query: 377 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 489 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 545
+T+ + L +A G E L++ A D+ L T L A+ GH + K LL
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 546 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
AN +A G T L AC+ V ++L++ GA +
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI 424
Score = 169 bits (429), Expect = 5e-42
Identities = 141/438 (32%), Positives = 210/438 (47%), Gaps = 45/438 (10%)
Query: 188 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 247
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 248 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 307
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 308 DIVKVLLNEGANIE------------------------DHN-------------ENGHTP 330
V +LL + DHN E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 331 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 510 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 566
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 567 NGHTDVADVLLQAGADLD 584
G +V LL+ GA +D
Sbjct: 474 AGQVEVVRCLLRNGALVD 491
Score = 168 bits (425), Expect = 2e-41
Identities = 128/388 (32%), Positives = 196/388 (50%), Gaps = 12/388 (3%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A G+ N V+ LLD G ++ T +G + L A +G+ ++ ++LL A + R G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
++PL A+ G +++ VK LL H A V+ + TAL A G + K+LL++ AN
Sbjct: 333 -LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 321 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMV 377
NG TPL A ++V +L+ +GA I ES LT +A + GHL++V
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQA----ITESGLTPIHVAAFMGHLNIV 447
Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
LL+ GA + TAL A G VEV R LL +GA V+ A ++PL +A+
Sbjct: 448 LLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
G E+ LL++ A+ + GYTPL +AREG ++ ++LL GA + T++ T
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKK-GFTP 566
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
L +A G +VA L++ A + TPL A+ + ++ LL GA+ HAT
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 555 ATGDTALTYACENGHTDVADVLLQAGAD 582
G T L A + +A LL GA+
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Score = 141 bits (355), Expect = 2e-33
Identities = 126/413 (30%), Positives = 186/413 (45%), Gaps = 11/413 (2%)
Query: 189 NAGQVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
N VD R+ E A G V+ LL + T G + L ++ G ++
Sbjct: 486 NGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
A VLL A K TPL A+ G LD+ KLLL A +S G T L A
Sbjct: 546 ASVLLEAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 303 AGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE 362
+ +LL +GA+ +NG+TPL AA +++A LL++GA N + +
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ-GV 663
Query: 363 SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 422
+ L LA +GH DMV LL+ GA+ T T+L A + V VA +L GA +
Sbjct: 664 TPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA 723
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
+PL +A G+V++ L+++GAN+ GYTPL +AA++GH ++ +LL
Sbjct: 724 HTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 542
GA NA T TAL +A G+ V D L K + +T + E + E +
Sbjct: 784 GAKPNA-TTANGNTALAIAKRLGYISVVDTL-KVVTEEVTTTTTTITEKHKLNVPETMTE 841
Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEG 595
+L T TGD Y ++ D L + LD ++ LEG
Sbjct: 842 VLDVSDEEGDDTMTGDGG-EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEG 893
Score = 125 bits (314), Expect = 1e-28
Identities = 91/297 (30%), Positives = 143/297 (48%), Gaps = 40/297 (13%)
Query: 326 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 385
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 386 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 445
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 446 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 496
L+E GAN ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 497 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 526
AL L A G VA L+ GA ++ T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 527 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
PL AS+ G+ +VK LL G + A T G T L A +GH V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Score = 85.5 bits (210), Expect = 1e-16
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 31/189 (16%)
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
K + + + + A G+++ L G +N + + L LAA GHV L L+ R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
G++++ +G T L A+ G E+V +L+ +GANINAQ++ GF
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ------------NGF--- 131
Query: 510 ADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGH 569
TPL A+QE H+++VKYLL +GAN T G T L A + GH
Sbjct: 132 ----------------TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGH 175
Query: 570 TDVADVLLQ 578
+LL+
Sbjct: 176 NQAVAILLE 184
Score = 68.6 bits (166), Expect = 2e-11
Identities = 64/228 (28%), Positives = 95/228 (41%), Gaps = 16/228 (7%)
Query: 183 KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYEL 242
K N H + + SL A + VN L G + HT+ G + L +AC G ++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 243 AQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYAC 302
LL ANV + K TPL A+ G+ I+ +LL H A N+ +A GNTAL A
Sbjct: 744 VNFLLKQGANVNAK-TKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 303 AGGF---VDIVKVLLNEGAN-----IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
G+ VD +KV+ E E H N + E E + G G
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG-GEY 861
Query: 355 THSNEFKE---SALTLACYKGHLDMVRFLLEAGAD---QEHKTDEMHT 396
+ KE +L + + ++ +R+ LE G + +D HT
Sbjct: 862 LRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT 909
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 169 bits (429), Expect = 5e-42
Identities = 125/399 (31%), Positives = 202/399 (50%), Gaps = 7/399 (1%)
Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
D SL +A +GD + VR L+ + VN E + L A G E+ ++L+ A V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
+ +K +TPL A + + V++LL H ADVN++ T L A A V + L
Sbjct: 68 NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
+ +N+ + G T L AA +GH E+ ++LL GA IN + + A+ A Y GH
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGH 185
Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
+++V+ L+ GA+ K + +T L A G + V + LLD G +N P +PL +
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492
A G + LI+ GA + + N++G+TPL AA H + + LL+ GA++N ++++
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGAN 549
+ A G FS + +I++GA I+ +TPL A++ GH L+ L+ SGA+
Sbjct: 306 GKTPLHMTALHGRFSR-SQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 550 VHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588
G L A +G +D LL +G D+D +D
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403
Score = 156 bits (394), Expect = 6e-38
Identities = 122/395 (30%), Positives = 201/395 (50%), Gaps = 17/395 (4%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVEDRGN 258
+CS+ AV+ LL VN + ++ L +A + + A+ L+ + + NV DR
Sbjct: 84 SCSE---EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAG 140
Query: 259 KGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA 318
+ T L A+ G+ ++VKLLL A++N+ A+ +A G +++VK+L++ GA
Sbjct: 141 R---TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGA 197
Query: 319 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378
+ ++ +TPL AAS+G + V + LLD G +N N + + L +ACY G +V
Sbjct: 198 EVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVN 256
Query: 379 FLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACG 437
L++ GA K ++ T L A H + LL+ +GA VNM + ++PL + A
Sbjct: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALH 316
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA 497
G + +I+ GA ++ + G TPL AAR GHE ++ L+ GA+ A+
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFP 375
Query: 498 LTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATT 554
L LA GFS+ L+ +G DI+ T L A+ G+LE + LL +GA+ +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 555 ATGDTALTYACENGHTDVADVLLQAGA---DLDKQ 586
G + L YA N + L+ +GA DLD++
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDER 470
Score = 136 bits (343), Expect = 5e-32
Identities = 109/352 (30%), Positives = 175/352 (49%), Gaps = 17/352 (4%)
Query: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
+ D N+ I+PL A+ G+ +++L+ D++ ++++G T L A G V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
Query: 313 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 368
L+N+GA+I +D+ TP+ AA+ GH E R+L+ + N + ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 369 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
GH D V LL GA+ + K TAL + GH E LL GA+ +
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 429 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 484
+P+ L+A GH+ + L++ A+++ ++ GYT L A GHE V LLL Q
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
Query: 485 NINAQTEETQETALTLACCGGFSEVADFLIKA-GADIELGCS----TPLMEASQEGHLEL 539
+ +TE + L A A+ LI GA I TPL A+ H+E
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVEC 838
Query: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLL-QAGADLDKQEDMK 590
++ LL+ A V++ +TG T L A ENG T+ ++L+ A A+L Q++ K
Sbjct: 839 LQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK 890
Score = 132 bits (331), Expect = 1e-30
Identities = 117/399 (29%), Positives = 181/399 (45%), Gaps = 27/399 (6%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 264
G + + ++ G ++ + G + L +A G+ L L+ A+ RG G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
Query: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 324
L A+ G+ D + LL D+++ G T L A AGG ++ + +LLN GA+ +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 380
+ G +PL AA+ + + L+ GA +N + E T Y D + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 381 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 428
L A+ + + + A+ + GH +L+ SG + +D+
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 488
SPL LAA GH + +L++ +L+ N G TPL AA +GH E V +L+ QGA+I
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 489 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELG-CSTPLMEASQEGHLELVKY 542
+ + T + A G SE LI + DI+ G TPLM + GH + V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 543 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
LL GANV A G TAL GH + D LLQ GA
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGA 710
Score = 131 bits (330), Expect = 2e-30
Identities = 109/378 (28%), Positives = 178/378 (47%), Gaps = 8/378 (2%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L A G V+ LL G ++N ++ + A G+ E+ ++L++ A V +
Sbjct: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
K TPL AA+S G + +VK LL D+N +A GNT L AC G +V L++
Sbjct: 203 DKKS-YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDC 261
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
GA + NE G TPL AA++ H + +L+ +GA +N S + K + L + G
Sbjct: 262 GAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFS 320
Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
+ ++++GA + + +T L A GH + L+ SGA PL LAA
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAA 380
Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQE 495
G + L+ G +++ +D G T L AA G+ E + LLL GA+ N + ++
Sbjct: 381 LSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGR 439
Query: 496 TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGANVH 551
+ L A + L+ +GA + E GC+ A+ + + ++YLL + AN
Sbjct: 440 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPG 499
Query: 552 ATTATGDTALTYACENGH 569
G A+ Y+ GH
Sbjct: 500 IRDKQGYNAVHYSAAYGH 517
Score = 130 bits (326), Expect = 5e-30
Identities = 124/421 (29%), Positives = 190/421 (45%), Gaps = 24/421 (5%)
Query: 171 ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGE 228
AL+ +L + NS +D A G V V L+++G S V ++ +
Sbjct: 565 ALEVLVQSLLDLDVRNSSGRTPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-R 618
Query: 229 SLLCLACSAGYYELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286
+ + A + G+ E ++L+ A N D + TPLM + G+ D V LL A+
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 287 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346
V+++ G TAL G + V LL GA + G TP+ +A+ GH+ V L
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 347 LDHGAGINTH---SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
L A ++ + ++ +AL ACY GH V LLE Q+ + + + L A +
Sbjct: 739 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVI 797
Query: 404 DGHVEVARLLLDS-GAQVNMPADS-FESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
+ + A +L+D+ GA + DS +PL AA HVE LL+ A + V+ G
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK 857
Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
TPLM AA G V +L++ + + ++ TAL LAC G A +++ D
Sbjct: 858 TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRN 917
Query: 522 L------GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
L TPL A++ G +V+ LL GA+V A G T N DVAD
Sbjct: 918 LINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPN--KDVADC 975
Query: 576 L 576
L
Sbjct: 976 L 976
Score = 129 bits (325), Expect = 6e-30
Identities = 119/403 (29%), Positives = 179/403 (44%), Gaps = 20/403 (4%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L A S G ++ V+ LLD G +NE G + L +AC G + L+ A V +
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
Query: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315
KG TPL AAS+ G L ++LL+ + ADVN +S G T L G + ++
Sbjct: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
Query: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
GA I+ ++NG+TPL AA GH + L+ GA L LA G D
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
R LL +G D + D T L A G++E LLL++GA N SPL AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 494
+ + L+ GA++ ++++ G TPL AA + + + LL AN + ++
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 495 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 540
A G D L++ L S +PL A+ GH + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
+ L+ S ++ ++G T L A GH + DVL+ GA +
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 167 bits (424), Expect = 2e-41
Identities = 135/461 (29%), Positives = 225/461 (48%), Gaps = 30/461 (6%)
Query: 134 DLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 193
D+ T+D E + L AA D E++ L S + R+ A+++ +
Sbjct: 8 DVNTLDSEKRTPLHV---AAFLGDAEIIELLILSGA-----------RVNAKDN-----M 48
Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HA 251
L A + AV+ L+ VN + ++ L +A + + A+V++ +
Sbjct: 49 WLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSV 108
Query: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
NV DRG + T L A+ G++++V LLL A++N+ AL +A G +D+V
Sbjct: 109 NVSDRGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVA 165
Query: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
+L+N GA + ++ G+TPL AAS G + V + LL+ G I+ N + +AL +ACY
Sbjct: 166 LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYN 224
Query: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESP 430
G +V L++ GA+ + T L A H + LL+++GA VN+ + +SP
Sbjct: 225 GQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSP 284
Query: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
L + A G + LI+ G ++ V+ +G TPL AAR GHE ++ L GA+ A+
Sbjct: 285 LHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKC 343
Query: 491 EETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASG 547
L LA S+ L+ +G +I+ T L A+ G++E +K L +SG
Sbjct: 344 GIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSG 403
Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQED 588
A+ H G T L YA N H + L+ GA++++ +D
Sbjct: 404 ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Score = 127 bits (319), Expect = 3e-29
Identities = 123/420 (29%), Positives = 177/420 (42%), Gaps = 37/420 (8%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L A S+G +N V+ LL+ G ++E G + L +AC G + L+ ANV
Sbjct: 185 LHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPN 244
Query: 258 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315
N G TPL AAS+ G L ++LL+ + ADVN QS G + L G + L+
Sbjct: 245 NNG-FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ 302
Query: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 375
G I+ +++G+TPL AA GH + L GA L LA H D
Sbjct: 303 NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHSMFPLHLAALNAHSD 361
Query: 376 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 435
R LL +G + + T L A G+VE +LL SGA + +PL AA
Sbjct: 362 CCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 421
Query: 436 CGGHVELAALLIERGANLEEVNDEGYTPL------------------------MEAAREG 471
H L+ GAN+ E +D G T L +E ARE
Sbjct: 422 ANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAREL 481
Query: 472 HEEMVAL----LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS-- 525
E+ L LL AN + + +E + A G + L + + E S
Sbjct: 482 KEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 526 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL 583
+PL A+ GH + ++ LL S ++ G TAL A GHT+ + L+ GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Score = 122 bits (305), Expect = 1e-27
Identities = 114/397 (28%), Positives = 180/397 (45%), Gaps = 20/397 (5%)
Query: 213 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM-HANVEDRGNKGDITPLMAASSG 271
LL + + +EG + + A + G+ + ++LL ++ E+ + +PL A+
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
Query: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI-EDHNENGHTP 330
G+ +++LL D++ + G TAL A G + V+ L+N GA+I N TP
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612
Query: 331 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESA----LTLACYKGHLDMVRFLLEAGAD 386
L + GH R+LL+ N + + K++ L LA GH+D V LLE A+
Sbjct: 613 LHASVINGHTLCLRLLLE--IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446
+ TAL M GH E ++LL+ + +PL AA GH + L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
Query: 447 IERGANLEEV---NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACC 503
++ + E+ +++GYTPL A G+E + +LL Q + T L A
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ--KCFRKFIGNPFTPLHCAII 788
Query: 504 GGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASGANVHATTATGD 558
A L+ A + C TPL A+ H+E ++ LL A V+A +G
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
Query: 559 TALTYACENGHTDVADVLL-QAGADLD-KQEDMKTIL 593
TAL A ENG D+L+ A ADL K +D+ T L
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPL 885
Score = 114 bits (285), Expect = 3e-25
Identities = 91/310 (29%), Positives = 147/310 (47%), Gaps = 7/310 (2%)
Query: 280 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
+L+H DVN+ + T L A G +I+++L+ GA + + TPL A ++
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 339 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 398
E +VL+ H A +N + ++ L +A + ++ + TAL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 399 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 458
A ++GHVE+ LLL GA +N L AA GH+++ ALLI GA + +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 459 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 518
+GYTPL AA G +V LL G I+ + TAL +AC G V + LI GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 519 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
++ + TPL A+ H L ++ L+ +GA+V+ + G + L +G +
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 575 VLLQAGADLD 584
L+Q G ++D
Sbjct: 299 TLIQNGGEID 308
Score = 107 bits (268), Expect = 2e-23
Identities = 78/244 (31%), Positives = 125/244 (51%), Gaps = 5/244 (2%)
Query: 345 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 404
+L+ +NT +E K + L +A + G +++ L+ +GA K + T L A
Sbjct: 1 MLIHKTEDVNTLDSE-KRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVAS 59
Query: 405 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 464
E ++L+ A VN ++++PL +AA V+ A ++I +++ + G T L
Sbjct: 60 RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 465 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---E 521
AA GH EMV LLLA+GANINA ++ AL A G +V LI GA++ +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINA-FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178
Query: 522 LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
TPL A+ G + +VK+LL G + G+TAL AC NG V + L+ GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 582 DLDK 585
++++
Sbjct: 239 NVNQ 242
Score = 104 bits (259), Expect = 3e-22
Identities = 105/409 (25%), Positives = 175/409 (42%), Gaps = 47/409 (11%)
Query: 179 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 238
L + + H + L A ++ + + L+ G +VNE + G + L A ++
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Query: 239 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 298
+L H N E+ ++ A ++ LL +DA+ + + G ++
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATL------CLEFLLQNDANPSIRDKEGYNSI 511
Query: 299 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 356
YA A G +++LL + + +++G T PL AA GH + VLL ++
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 414
+E +AL LA +KGH + V L+ GA K + T L + ++GH RLLL
Sbjct: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 415 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 472
D+ V++ ++PL LA GH++ +LL+E+ AN++ V+ G T L GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEAS 532
EE V +LL Q +I + + TPL A+
Sbjct: 691 EECVQMLLEQEVSILCKDSRGR-------------------------------TPLHYAA 719
Query: 533 QEGHLELVKYLL---ASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
GH + LL S + G T L +AC NG+ + +VLL+
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLE 768
Score = 95.1 bits (235), Expect = 2e-19
Identities = 107/388 (27%), Positives = 169/388 (43%), Gaps = 33/388 (8%)
Query: 152 AAAFADPEVLRRLTSSVSCALDEAAAALTR----MKAENSHN-AGQVDTRSLAE------ 200
AAA+ + L L + +E+ + T+ + A N H+ A +V +SL +
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 201 --------ACSDGDVNAVRKLLDEGRSVN-EHTEEGESLLCLACSAGYYELAQVLLAMHA 251
A G V L++ G S+ + + L + G+ ++LL +
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 252 N---VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
N V+ + KG TPLM A + G++D V LLL +A+V++ G TAL G +
Sbjct: 634 NPEAVDVKDAKGQ-TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEE 692
Query: 309 IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKE----SA 364
V++LL + +I + G TPL AA+ GH LL ++ FK+ +
Sbjct: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ--MALSEEDCCFKDNQGYTP 750
Query: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS--GAQVNM 422
L ACY G+ + + LLE ++ T L A ++ H A LLL + + V+
Sbjct: 751 LHWACYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSC 809
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
D +PL AA HVE LL+ A + V++ G T LM AA G V +L+
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 483 GANINAQTEETQETALTLACCGGFSEVA 510
++ T L LAC G + A
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCA 897
Score = 79.7 bits (195), Expect = 7e-15
Identities = 77/275 (28%), Positives = 121/275 (44%), Gaps = 9/275 (3%)
Query: 212 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 271
++ D +V+ +G++ L LA + G+ + +LL ANV+ G T L
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
Query: 272 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 328
G+ + V++LL + + + + G T L YA A G + LL + ED + G+
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
Query: 329 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA--GAD 386
TPL A G+ VLL+ N F + L A H + LL A +
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPF--TPLHCAIINDHGNCASLLLGAIDSSI 806
Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALL 446
+ D+ T L A HVE +LLL A VN +S ++ L +AA G +L
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDIL 866
Query: 447 IERG-ANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
+ A+L + + TPL A +GHE+ L+L
Sbjct: 867 VNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/316 (27%), Positives = 137/316 (43%), Gaps = 50/316 (15%)
Query: 146 LEALLE--AAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS------ 197
+EAL+ A+ F V +R + + ++ R+ E + N VD +
Sbjct: 591 VEALINPGASIFVKDNVTKR--TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTP 648
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L A + G ++AV LL++ +V+ G + L G+ E Q+LL ++ +
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKD 708
Query: 258 NKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
++G TPL A++ G+ + LL L + D + G T L +AC G + ++VLL
Sbjct: 709 SRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 315 NEG---------------ANIEDH-------------------NENGHTPLMEAASAGHV 340
+ A I DH ++ G TPL AA A HV
Sbjct: 768 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827
Query: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALM 399
E ++LL H A +N N K +AL +A G V L+ A AD K +++T L
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGK-TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886
Query: 400 EACMDGHVEVARLLLD 415
AC GH + A L+LD
Sbjct: 887 LACSKGHEKCALLILD 902
Score = 34.3 bits (77), Expect = 0.35
Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 225 EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG--GYLDIVKLLLL 282
++G + L A A + E Q+LL A V N G +MAA +G G +DI L+
Sbjct: 812 DKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDI--LVNS 869
Query: 283 HDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
AD+ + NT L AC+ G ++L++
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 167 bits (422), Expect = 3e-41
Identities = 120/394 (30%), Positives = 210/394 (53%), Gaps = 12/394 (3%)
Query: 195 TRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL--AMHAN 252
++S+ + ++ A++ LL++ + V+E E G++ L +A G E+ + L+ + N
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
Query: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
+ED N T L++AS G++ IV+ LL ++ + G TAL +AC G D+V++
Sbjct: 66 LEDLDNW---TALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVEL 122
Query: 313 LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372
LL+ GAN P++ AA GH ++ +LL +GA +N S+++ + L A KG
Sbjct: 123 LLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC-SDKYGTTPLVWAARKG 181
Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
HL+ V+ LL GAD + + TAL+ A G+ + + +L VN+ + L
Sbjct: 182 HLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALM 241
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+A+ GH E+ L++ G + + G T L+ A R GH E+V LL + A+I+ + ++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGA 548
+TAL A G + + +++ D E+ C+ TPL++A++ ++E+V+ LL GA
Sbjct: 302 -NKTALYWAVEKGNATMVRDILQCNPDTEI-CTKDGETPLIKATKMRNIEVVELLLDKGA 359
Query: 549 NVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
V A GDT L A +A++LL+ D
Sbjct: 360 KVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKD 393
Score = 166 bits (421), Expect = 4e-41
Identities = 107/291 (36%), Positives = 163/291 (56%), Gaps = 6/291 (2%)
Query: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366
+ +K LL + ++++ NE G TPLM AA G++E+ + L+ +GA N + +AL
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
Query: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426
A +GH+ +V LL+ G + EH+ TALM AC G +V LLL GA ++
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 427 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 486
P+ AA GH ++ LL++ GA + + G TPL+ AAR+GH E V LLA GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 487 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 543
+ Q TAL +A GG+++ ++K ++ L +T LM AS+EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593
L +G V+ +GDT L A GH ++ LLQ AD+D + +D KT L
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTAL 306
Score = 139 bits (349), Expect = 1e-32
Identities = 97/311 (31%), Positives = 154/311 (49%), Gaps = 5/311 (1%)
Query: 277 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 336
+K LL DV+ ++ G T L A G ++IVK L+ GAN + + T L+ A+
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 337 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 396
GHV + LL G + H + +AL ACYKG D+V LL GA+
Sbjct: 81 EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
Query: 397 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456
++ A GH ++ LLL +GA+VN +PL AA GH+E L+ GA++++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516
T L+ A + G+ + V +L + N+N T++ TAL +A G +E+ L+ A
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
Query: 517 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573
G + + T L+ A + GH+E+V+ LL A++ TAL +A E G+ +
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
Query: 574 DVLLQAGADLD 584
+LQ D +
Sbjct: 319 RDILQCNPDTE 329
Score = 36.2 bits (82), Expect = 0.091
Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 250
GQ + +L A G+ VR +L T++GE+ L A E+ ++LL
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
Query: 251 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286
A V KGD TPL A G + +LLL + D
Sbjct: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 159 bits (403), Expect = 5e-39
Identities = 136/434 (31%), Positives = 213/434 (49%), Gaps = 15/434 (3%)
Query: 126 LSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAE 185
LS G PE +R + + + + L ++S S + +L+ +
Sbjct: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREP 395
Query: 186 NSHNAGQVDT--RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELA 243
++ + G D + L +A GD + + K+L + + V+ + G SLL LA AG E A
Sbjct: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLHLAVEAGQEECA 454
Query: 244 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 303
+ LL +AN +G TPL A +V+LLL VN++ TAL +A
Sbjct: 455 KWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQ 513
Query: 304 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 363
G ++LL + A++ + + G TP+ A G + R+LL G ++ K++
Sbjct: 514 NGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG---KDA 570
Query: 364 ALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 420
L L A ++GHL +V+ L + G +T + T L A GH VAR+L+D + V
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 421 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 480
N+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR GH V LL+
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLV 690
Query: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCSTPLMEASQEGHL 537
+ A++ A+ Q TAL LA G SEV + L+ A D+ E G S L A+Q H
Sbjct: 691 EEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA-LHLAAQGRHA 748
Query: 538 ELVKYLLASGANVH 551
+ V+ LL GA+++
Sbjct: 749 QTVETLLRHGAHIN 762
Score = 110 bits (275), Expect = 4e-24
Identities = 88/263 (33%), Positives = 132/263 (50%), Gaps = 6/263 (2%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A +GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KD 569
Query: 261 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 319
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ ++
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 320 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 379
+ + TPL AA GH AR+LL GAG +++ +AL LA GHL V+
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKL 688
Query: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
L+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 689 LVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRH 747
Query: 440 VELAALLIERGA--NLEEVNDEG 460
+ L+ GA NL+ + +G
Sbjct: 748 AQTVETLLRHGAHINLQSLKFQG 770
Score = 106 bits (264), Expect = 7e-23
Identities = 87/264 (32%), Positives = 127/264 (48%), Gaps = 8/264 (3%)
Query: 325 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 384
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 385 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 503
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
Query: 504 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
Query: 560 ALTYACENGHTDVADVLLQAGADL 583
AL A NGH +L++ AD+
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADV 696
Score = 57.0 bits (136), Expect = 5e-08
Identities = 54/196 (27%), Positives = 79/196 (40%), Gaps = 32/196 (16%)
Query: 391 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 450
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 451 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 510
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFA--------- 511
Query: 511 DFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 570
+Q G + LL A+V+ G T + AC++G
Sbjct: 512 ---------------------AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQE 550
Query: 571 DVADVLLQAGADLDKQ 586
++ +LL+ G D+ Q
Sbjct: 551 NIVRILLRRGVDVSLQ 566
Score = 32.7 bits (73), Expect = 1.0
Identities = 31/107 (28%), Positives = 46/107 (42%), Gaps = 3/107 (2%)
Query: 490 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 547
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQEDMKTIL 593
AN + + G T L A E V ++LL ++ K ED T L
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTAL 508
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 154 bits (389), Expect = 2e-37
Identities = 123/353 (34%), Positives = 167/353 (47%), Gaps = 6/353 (1%)
Query: 238 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 297
G E ++LLA +V+ + G TPL+ A+ D+ LLL H AD N G
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
Query: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
L +A G ++LL+ GA ++ G TPL AA VAR+L+ A N H
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
Query: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417
E K + L +A Y GH+ +V+ L GA+ + + + T L A G V + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 418 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 477
A + S PL AA G + +L+ GA+LE +G+TPL AA +GH E++
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 478 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 534
LL AN+ A T L LA G V L++ GAD E TPL A Q
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 535 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
V LL ANVHA G T A G+T + VL++AGA LD Q+
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQD 722
Score = 131 bits (330), Expect = 2e-30
Identities = 110/365 (30%), Positives = 173/365 (47%), Gaps = 6/365 (1%)
Query: 203 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 262
+ G V VR LL V+ T G + L +A +L +LLA H +R ++
Sbjct: 371 AQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA-HGADANRVDEDGW 429
Query: 263 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 322
PL A+ G +LLL H A V++Q G T L A F ++ ++L++ A+
Sbjct: 430 APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNL 489
Query: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
H G TPL AA GHV + ++L GA ++ + + L LA +G + ++ LL+
Sbjct: 490 HEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLK 548
Query: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
+GA + + L A G + ++LL GA + +P +PL LAA GH+E+
Sbjct: 549 SGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEI 608
Query: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
LL E AN+ + +TPL AAR G E +V+ LL GA+ NA E++ T L LA
Sbjct: 609 IHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA-AEQSGWTPLHLAV 667
Query: 503 CGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
L++ A++ TP A+ +G+ ++K L+ +GA + T
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCT 727
Query: 560 ALTYA 564
L A
Sbjct: 728 PLQLA 732
Score = 118 bits (295), Expect = 2e-26
Identities = 106/355 (29%), Positives = 165/355 (46%), Gaps = 24/355 (6%)
Query: 138 VDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS 197
VD +T + LL AA P++ CAL A A +A +VD
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDL---------CALLLAHGA----------DANRVDEDG 428
Query: 198 LAE---ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVE 254
A A +GD R LLD G V+ EG + L LA + +A++L++ A+
Sbjct: 429 WAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPN 488
Query: 255 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
+G TPL A+ G++ +VKLL A++++Q T L A G V ++ LL
Sbjct: 489 LHEAEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
Query: 315 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
GA + +++G+ PL AA+ G + ++LL +GA + +++ + L LA YKGHL
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHL 606
Query: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434
+++ L E+ A+ T L A G V LL GA N S +PL LA
Sbjct: 607 EIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLA 666
Query: 435 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 489
L+E AN+ N G+TP AA +G+ ++ +L+ GA ++ Q
Sbjct: 667 VQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Score = 90.5 bits (223), Expect = 4e-18
Identities = 78/268 (29%), Positives = 124/268 (46%), Gaps = 8/268 (2%)
Query: 324 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 379
NE+ LM++ S +++ A L D + E K + L +G ++ VR
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
Query: 380 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
LL D + +T +T L+ A D ++ LLL GA N + +PL AA G
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
Query: 440 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 499
A LL++ GA ++ EG+TPL AA+ E + LL+++ A+ N E +T L
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
Query: 500 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 556
+A G + L GA+++ TPL A + G + +++LL SGA A +
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
Query: 557 GDTALTYACENGHTDVADVLLQAGADLD 584
G L A G + +LL+ GA L+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLE 587
Score = 38.9 bits (89), Expect = 0.014
Identities = 22/63 (34%), Positives = 35/63 (55%)
Query: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
TPL +G +E V+ LLA +V TA+G T L A ++ D+ +LL GAD ++
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 586 QED 588
++
Sbjct: 424 VDE 426
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 148 bits (374), Expect = 1e-35
Identities = 117/364 (32%), Positives = 181/364 (49%), Gaps = 23/364 (6%)
Query: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
+++++L+ AN+ R + P++ S GY ++V LLL A+V++ S +G T L
Sbjct: 864 KVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPLG 923
Query: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLD-------HGAG 352
YA A G++ IV +L + A ++ ++NG L+ AA GH+EV + L+ G
Sbjct: 924 YAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQG 983
Query: 353 INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEM----------HTALMEAC 402
+ S+ ++ AL A G+ ++V +LL+ E + + TAL A
Sbjct: 984 VFKKSHAIQQ-ALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAA 1042
Query: 403 MDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT 462
G +EV RLLL+ GA V P PL GH ++ LL+ GA++ + +G T
Sbjct: 1043 GRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRT 1102
Query: 463 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---D 519
PLM AA EGH V LLAQGA+I A ++ TAL+ AC G V L+ GA
Sbjct: 1103 PLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDH 1161
Query: 520 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA 579
+ TPL A+ G E+V++L+ GA + +G L A +T V LL+
Sbjct: 1162 ADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
Query: 580 GADL 583
GA +
Sbjct: 1222 GAKI 1225
Score = 144 bits (364), Expect = 2e-34
Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)
Query: 206 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
++ R L+ G ++N TE +LC+ GY E+ +LL ANV D ++ +T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
Query: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 316
PL A++ GYL IV LL A V+ G AL +A G +++VK L+ +
Sbjct: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
Query: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 367
+ + L+ AAS G+ E+ LLD A IN+ + + E+ALT
Sbjct: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
Query: 368 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
A +G L++ R LLE GA L GH ++ LLL GA VNM
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
Query: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
+PL +AA GH+ L+ +GA++ ++ EG T L A +GH +V L+ GA +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
Query: 488 AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 544
++ T L LA G +EV FL+ GA IE PL A + +V LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
Query: 545 ASGANVHATT 554
GA + T
Sbjct: 1220 KKGAKIGPAT 1229
Score = 140 bits (352), Expect = 4e-33
Identities = 109/334 (32%), Positives = 172/334 (51%), Gaps = 26/334 (7%)
Query: 274 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 331
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
Query: 332 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 386
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
Query: 387 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 433
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVN-MADKQ 1099
Query: 494 QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 550
T L +A G DFL+ GA I L T L A +GHL +V+ L+ +GA
Sbjct: 1100 GRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAAT 1159
Query: 551 HATTATGDTALTYACENGHTDVADVLLQAGADLD 584
G T L A G +V L+ GA ++
Sbjct: 1160 DHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE 1193
Score = 132 bits (333), Expect = 7e-31
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
Query: 264 --------------------------------------PLMAASSGGYLDIVKLLL---- 281
L+AA+S GY +IV LL
Sbjct: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
Query: 282 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 335
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
Query: 336 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
Query: 396 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 455
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
Query: 456 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 513
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
Query: 514 IKAG 517
K G
Sbjct: 1255 YKKG 1258
Score = 36.6 bits (83), Expect = 0.070
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
Query: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 148 bits (373), Expect = 2e-35
Identities = 144/446 (32%), Positives = 198/446 (44%), Gaps = 61/446 (13%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L AC GD R+LL+ G + E E G A AG A V G
Sbjct: 13 LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
AA++G V V+ GNTAL +A AGG +V+ LL G
Sbjct: 59 ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
A++ N G + LM+AA GHV VA +LLDHGA +N N S LT+A GHL +V
Sbjct: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
Query: 378 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 423
+ LLEAGA D H + E TALM A GH V RLL++ GA N
Sbjct: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
Query: 424 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
A + SPL LAA G + +A L+E+GAN + ++ T A H ++V L
Sbjct: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
Query: 483 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 538
EE + + A G F V + + + + L +TPLM A+ G L
Sbjct: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
Query: 539 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLDKQE-------DMK 590
LV+ L+ A+V + G TAL A +G+ ++ LL GAD+ + D+
Sbjct: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLV 400
Query: 591 TILEGIDPAKHQVRVAFDACKLLRKE 616
+L DP VR+ C + K+
Sbjct: 401 MLLN--DPDTELVRLLASVCMQVNKD 424
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 146 bits (369), Expect = 5e-35
Identities = 115/391 (29%), Positives = 191/391 (48%), Gaps = 7/391 (1%)
Query: 194 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
D L +A DV VR LL + ++N +E + L A G + Q+LL ANV
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
+ +TPL A++ ++ LLL H ADVN++ T L A A + L
Sbjct: 68 NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
+++ + +G + L A +GH+E +LL+ GA +N + ++ L A + GH
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
L++++ L+ GAD K + + L A G +EV + LL GA+++ P + L +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 492
A G +A L+ GAN+ + ND+G+TPL AA + + + LL+ GA++N Q++E
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGAN 549
+ A G F+ + LI+ G++I+ +TPL A++ GH L+ L+ +GA+
Sbjct: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
Query: 550 VHATTATGDTALTYACENGHTDVADVLLQAG 580
L A G +D LL +G
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 128 bits (321), Expect = 2e-29
Identities = 132/484 (27%), Positives = 213/484 (44%), Gaps = 25/484 (5%)
Query: 130 AEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHN 189
+ GADLR D + L ++ L + V+ A + + L A +++
Sbjct: 444 SSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503
Query: 190 AGQVDTRSLAEACSDGDVNAVRK---------LLDEGRSVNEHTEEGESLLCLACSAGYY 240
+ T S +A D + R+ LLD G + +G + + A + G
Sbjct: 504 RAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNR 563
Query: 241 ELAQVLLAMHAN-VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT 299
+ ++LL M N +ED + ++PL A+ G+ + +K L +++ + G TAL
Sbjct: 564 QNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALF 623
Query: 300 YACAGGFVDIVKVLLNEGAN-IEDHNENGHTPLMEAASAGHVEVARVLLDHG--AGINTH 356
A G + V+VL GA+ + + TPL AA++GH + +L+D G A I
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
Query: 357 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 416
+ + ++ L LA GH+D V LLE G+ + TAL + G + LLD
Sbjct: 684 MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH 743
Query: 417 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGH 472
A V +P+ LA+ GH + L++ + + V+ GY+P+ A+ GH
Sbjct: 744 DAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH 803
Query: 473 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA-GADI----ELGCSTP 527
E+ + LLL + E T L A + L+ A GA I + TP
Sbjct: 804 EDCLELLLEHSPF--SYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861
Query: 528 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG-ADLDKQ 586
L A+ ++ ++ LL A V+AT TG TAL A ENG T + LL G ADL
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 587 EDMK 590
++ K
Sbjct: 922 DENK 925
Score = 119 bits (298), Expect = 8e-27
Identities = 141/563 (25%), Positives = 215/563 (38%), Gaps = 108/563 (19%)
Query: 123 EIFLSSTAEGADLRTVDPETQARLEA-------------LLEAAAFADPEVLRRLTSSVS 169
E+ A GADL D + L L A +P ++
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Query: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNEHTE 225
C L + A A+ + A N Q + + A S + L++ G VN ++
Sbjct: 247 CYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSK 304
Query: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---- 281
EG+S L +A G + +Q+L+ + + D +K TPL A+ G+ ++ L+
Sbjct: 305 EGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 282 ------LHDA-----------------------------------------DVNSQSATG 294
+HD D+N+ G
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG 423
Query: 295 NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGIN 354
T L A +GG V+ + +LL+ GA++ ++ G TPL AA+ G + A L+ GAG+N
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483
Query: 355 ----------------------------THSNEFKESALTLACYKGHLDMVRFLLEAGAD 386
+H E ++ L + K + FLL+ GAD
Sbjct: 484 EADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDNGAD 542
Query: 387 QEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVELAA 444
+ + +TA+ A G+ + LLL+ +S SPL LAA GH E
Sbjct: 543 PSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALK 602
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
L E NL+ + +G T L A G E V +L A GA+ + + + T L A
Sbjct: 603 TLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAAS 662
Query: 505 GFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGD 558
G ++ LI +G ADI + TPLM A GH++ V LL G+ A G
Sbjct: 663 GHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR 722
Query: 559 TALTYACENGHTDVADVLLQAGA 581
TAL G D LL A
Sbjct: 723 TALHRGAVTGCEDCLAALLDHDA 745
Score = 110 bits (274), Expect = 5e-24
Identities = 88/264 (33%), Positives = 127/264 (48%), Gaps = 9/264 (3%)
Query: 330 PLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 389
PL++A + VE R LL IN E + + L A Y G + +++ LL +GA+
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQE-RRTPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 390 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 449
K T L A + +V LLL A VN +++PL +AA + A L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 450 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 509
++L + G + L A GH E V LLL +GA++N ++ + L A G EV
Sbjct: 130 LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV-CDKKERQPLHWAAFLGHLEV 188
Query: 510 ADFLIKAGADIELGCSTP-----LMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 564
L+ GAD LGC L A+ G +E+VKYLL GA + A G+TAL A
Sbjct: 189 LKLLVARGAD--LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIA 246
Query: 565 CENGHTDVADVLLQAGADLDKQED 588
C G VA L+ AGA++++ D
Sbjct: 247 CYLGQDAVAIELVNAGANVNQPND 270
Score = 105 bits (262), Expect = 1e-22
Identities = 116/423 (27%), Positives = 172/423 (40%), Gaps = 50/423 (11%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLA------------ 248
A +G A++ L + +++ +G + L LA G E +VL A
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Query: 249 ----MHANVE-----------DRGNKGDIT---------PLMAASSGGYLDIVKLLLLHD 284
+HA D G + DIT PLM A G++D V LLL
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
Query: 285 ADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 344
+ ++ G TAL G D + LL+ A + + G TP+ A++ GH V R
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771
Query: 345 VLLDHGAG---INTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
LL ++ + S + A Y GH D + LLE + + T L A
Sbjct: 772 TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCA 830
Query: 402 CMDGHVEVARLLLDS-GAQ-VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 459
++ +LL + GA+ VN +PL AA +V +L++ A + +
Sbjct: 831 VINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHT 890
Query: 460 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 519
G T LM AA G V LL +G +E + TAL LAC G + A ++ D
Sbjct: 891 GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQD 950
Query: 520 IELGCST------PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 573
+ L +T PL A++ G +V+ LL+ GA V A G T N DVA
Sbjct: 951 LGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN--KDVA 1008
Query: 574 DVL 576
D L
Sbjct: 1009 DCL 1011
Score = 66.2 bits (160), Expect = 8e-11
Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 253
LA AC G +R LL S + G S + A G+ + ++LL
Sbjct: 760 LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 311
GN TPL A ++LL L VNS+ A G T L A V ++
Sbjct: 818 YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
Query: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
+LL A + + G T LM AA G LL G T +E K +AL LAC K
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
Query: 372 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 431
GH +L D +N + + PL
Sbjct: 936 GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
Query: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 481
+AA G + L+ GA + V++EG+TP + A + + +AL+L+
Sbjct: 966 HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
Score = 61.2 bits (147), Expect = 3e-09
Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)
Query: 253 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 312
V R KG TPL AA+ + +++LL H A+VN+ TG TAL A G V+
Sbjct: 851 VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
Query: 313 LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 369
LL G A++ +EN +T L A S GH + A ++L G+ +N + L +A
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
Query: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 426
G +V+ LL GA +E HT + + V L+ S + P D+
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
Score = 35.4 bits (80), Expect = 0.16
Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 31/127 (24%)
Query: 463 PLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL 522
PL++A E V LL+Q NIN +E +
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERR---------------------------- 42
Query: 523 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 582
TPL A+ G + +++ LL SGANV+A T L A + + V +LL AD
Sbjct: 43 ---TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSAD 99
Query: 583 LDKQEDM 589
++ ++ +
Sbjct: 100 VNARDKL 106
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 143 bits (361), Expect = 4e-34
Identities = 139/437 (31%), Positives = 199/437 (45%), Gaps = 54/437 (12%)
Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 253
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 243 HAR-DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
L GA+ N +G + L+EAA +G+ E LL +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNV 360
Query: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
LL GA VN +PL AA VE+ +LL+ GA+ VN D TP
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
Query: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG---GFSE 508
L++AARE V LA IN + ++ ETAL A +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
Query: 509 VADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 566 ENGHTDVADVLLQAGAD 582
GH +LL G+D
Sbjct: 600 LAGHLQTCRLLLSYGSD 616
Score = 132 bits (331), Expect = 1e-30
Identities = 139/494 (28%), Positives = 205/494 (41%), Gaps = 84/494 (17%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 251
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
Query: 252 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 295
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
Query: 296 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 352
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
Query: 353 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
+N H EFK +L A + L V+ L +
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
Query: 396 TALMEACMDGHV---EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 452
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA------------------------ 488
+ ++ G T L AA GH + LLL+ G++ +
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
Query: 489 --QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYL 543
+T + L + G V D+E STPL A+ + +V+YL
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
Query: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK--TILEGIDPAKH 601
L GA+VHA G L AC GH +VA++L++ GA ++ + K + E K+
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
Query: 602 QVRVAFDACKLLRK 615
++ CKLL K
Sbjct: 764 EI------CKLLLK 771
Score = 131 bits (329), Expect = 2e-30
Identities = 129/441 (29%), Positives = 199/441 (45%), Gaps = 59/441 (13%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 253
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Query: 314 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 347
L+ G++ + G T L+EA+ AG +E + L
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670
Query: 348 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 406
+N E + S L A + +V +LL GAD K L AC GH
Sbjct: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
Query: 407 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL
Sbjct: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787
Query: 466 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 504
+ +EG ++ LL A NIN + T+ T L LA
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
Query: 505 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
EVA++L++ GAD+ + G PL A+ GH+++ L+ V+AT T L
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 562 TYACENGHTDVADVLLQAGAD 582
A + G T + +LL GAD
Sbjct: 908 HEAAQKGRTQLCALLLAHGAD 928
Score = 112 bits (279), Expect = 1e-24
Identities = 104/314 (33%), Positives = 153/314 (48%), Gaps = 25/314 (7%)
Query: 209 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG-DITPLMA 267
AV+++L E + T + + L A AG E + L + NV R +G TPL
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690
Query: 268 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 327
A+ + +V+ LL H ADV+++ G L AC+ G ++ ++L+ GA++ +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 328 HTPLMEAASAGHVEVARVLLDHGAGI-------NTHSNEFKE------------SALTLA 368
TPL EAA+ G E+ ++LL HGA NT + KE +AL A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810
Query: 369 CYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 427
KG L V+ L T + T L A ++EVA LL+ GA VN
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
Query: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
PL AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
Query: 488 AQTEETQETALTLA 501
+ +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
Query: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 142 bits (359), Expect = 7e-34
Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)
Query: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
+++++L+ ANV R + P++ S G+ ++V LLL A ++ S G TAL
Sbjct: 906 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 965
Query: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350
YA A G + +V +L +G ++ ++ G L+ +A GH ++ + LL G
Sbjct: 966 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
Query: 351 AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403
+H+ + ALT A GH +V+ LL G ++EH+ TD + TAL A
Sbjct: 1026 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1080
Query: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
G +EV LLL GA V+ PL AA GH ++ LL+ERG ++ + +G TP
Sbjct: 1081 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1140
Query: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
LM AA EGH V LL++GA +++ +E +AL+ AC G V +L++ GA I+
Sbjct: 1141 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1199
Query: 523 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
TPL A+ G E V YL+ GA + +G L A +T V LL+ G
Sbjct: 1200 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1259
Query: 581 ADL 583
A L
Sbjct: 1260 AKL 1262
Score = 131 bits (330), Expect = 2e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 206 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
Query: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 963 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
Query: 320 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
Query: 550 VHATTATGDTALTYACENGHTDVADVLLQ 578
+ G+ A +A D+ +LLQ
Sbjct: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
Score = 129 bits (323), Expect = 1e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
Query: 264 --------------------------------------PLMAASSGGYLDIVKLLL---- 281
L AA+S G+ +V+ LL
Sbjct: 998 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
Query: 282 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
Query: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
Query: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
Query: 461 YTPLMEAAREGHEEMVALLLAQGANI 486
PL A + +V LL +GA +
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
Score = 128 bits (321), Expect = 2e-29
Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)
Query: 276 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 907 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
Query: 334 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 967 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
Query: 389 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
Query: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
Query: 562 TYACENGHTDVADVLLQAGADLDKQE 587
++AC GH V L++ GA +D+ +
Sbjct: 1175 SWACLKGHRAVVQYLVEEGAAIDQTD 1200
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)
Query: 162 RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218
RR + CA + + R+ E + D + L A +G ++ V LL +G
Sbjct: 1102 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1161
Query: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
+++ +EG S L AC G+ + Q L+ A + D+ +K TPL A+ G + V
Sbjct: 1162 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1220
Query: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
L+ A + +G L A +V LL +GA +
Sbjct: 1221 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1262
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 142 bits (359), Expect = 7e-34
Identities = 119/363 (32%), Positives = 182/363 (50%), Gaps = 26/363 (7%)
Query: 241 ELAQVLLAMHANVEDRGNKGDITPLMAASSG-GYLDIVKLLLLHDADVNSQSATGNTALT 299
+++++L+ ANV R + P++ S G+ ++V LLL A ++ S G TAL
Sbjct: 914 KVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALC 973
Query: 300 YACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL---------DHG 350
YA A G + +V +L +G ++ ++ G L+ +A GH ++ + LL G
Sbjct: 974 YAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
Query: 351 AGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK-----TDEM--HTALMEACM 403
+H+ + ALT A GH +V+ LL G ++EH+ TD + TAL A
Sbjct: 1034 TLRKSHA---LQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWGETALTAAAG 1088
Query: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
G +EV LLL GA V+ PL AA GH ++ LL+ERG ++ + +G TP
Sbjct: 1089 RGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTP 1148
Query: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
LM AA EGH V LL++GA +++ +E +AL+ AC G V +L++ GA I+
Sbjct: 1149 LMVAACEGHLSTVEFLLSKGAALSSLDKEGL-SALSWACLKGHRAVVQYLVEEGAAIDQT 1207
Query: 523 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
TPL A+ G E V YL+ GA + +G L A +T V LL+ G
Sbjct: 1208 DKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKG 1267
Query: 581 ADL 583
A L
Sbjct: 1268 AKL 1270
Score = 131 bits (330), Expect = 2e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 206 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 263
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
Query: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 319
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
Query: 320 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 372
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 373 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
Query: 493 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 549
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
Query: 550 VHATTATGDTALTYACENGHTDVADVLLQ 578
+ G+ A +A D+ +LLQ
Sbjct: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
Score = 129 bits (323), Expect = 1e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 205 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 263
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
Query: 264 --------------------------------------PLMAASSGGYLDIVKLLL---- 281
L AA+S G+ +V+ LL
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
Query: 282 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
Query: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
Query: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 460
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
Query: 461 YTPLMEAAREGHEEMVALLLAQGANI 486
PL A + +V LL +GA +
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
Score = 128 bits (321), Expect = 2e-29
Identities = 98/326 (30%), Positives = 160/326 (49%), Gaps = 46/326 (14%)
Query: 276 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 333
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
Query: 334 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 388
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
Query: 389 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 441
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
Query: 442 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 501
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
Query: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
Query: 562 TYACENGHTDVADVLLQAGADLDKQE 587
++AC GH V L++ GA +D+ +
Sbjct: 1183 SWACLKGHRAVVQYLVEEGAAIDQTD 1208
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/162 (25%), Positives = 70/162 (43%), Gaps = 4/162 (2%)
Query: 162 RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRS---LAEACSDGDVNAVRKLLDEGR 218
RR + CA + + R+ E + D + L A +G ++ V LL +G
Sbjct: 1110 RRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGA 1169
Query: 219 SVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVK 278
+++ +EG S L AC G+ + Q L+ A + D+ +K TPL A+ G + V
Sbjct: 1170 ALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAI-DQTDKNGRTPLDLAAFYGDAETVL 1228
Query: 279 LLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 320
L+ A + +G L A +V LL +GA +
Sbjct: 1229 YLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAKL 1270
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 142 bits (359), Expect = 7e-34
Identities = 129/440 (29%), Positives = 205/440 (46%), Gaps = 57/440 (12%)
Query: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 253
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Query: 314 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 352
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
Query: 353 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 407
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
Query: 408 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 466
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
Query: 467 AAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCGG 505
++G ++ LL A N+N + T+ T L LA
Sbjct: 631 LVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYN 690
Query: 506 FSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 562
EVA++L++ GAD+ + G PL A+ GH+++ L+ A V+AT T L
Sbjct: 691 NLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH 750
Query: 563 YACENGHTDVADVLLQAGAD 582
A + G T + +LL GAD
Sbjct: 751 EAAQKGRTQLCALLLAHGAD 770
Score = 139 bits (351), Expect = 6e-33
Identities = 133/437 (30%), Positives = 198/437 (45%), Gaps = 54/437 (12%)
Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 253
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
Query: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
L GA N +G T L+E+A +G+ E LL +
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
Query: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
Query: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 508
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 509 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 566 ENGHTDVADVLLQAGAD 582
GH +LL G D
Sbjct: 442 YCGHLQTCRLLLSYGCD 458
Score = 120 bits (301), Expect = 4e-27
Identities = 106/302 (35%), Positives = 147/302 (48%), Gaps = 19/302 (6%)
Query: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 253
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
L GA+ N +G+TPL + G ++ +L ++AL A KG
Sbjct: 612 LQHGADPTKKNRDGNTPL-DLVKDGDTDIQDLLRG-------------DAALLDAAKKGC 657
Query: 374 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 432
L V+ L T H T L A ++EVA LL GA VN PL
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
Query: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
AA GHV++AALLI+ A + + +TPL EAA++G ++ ALLLA GA+ + +E
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Query: 493 TQ 494
Q
Sbjct: 778 GQ 779
Score = 119 bits (298), Expect = 8e-27
Identities = 126/455 (27%), Positives = 199/455 (43%), Gaps = 49/455 (10%)
Query: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLA 248
G+ L E+ G+ + LL +VN H +G L +AGY ++ Q+LL
Sbjct: 174 GEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
Query: 249 MHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVD 308
A+V + +KGD+ PL A S G+ ++ +LL+ H A VN+ T L A + V+
Sbjct: 233 HGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVE 291
Query: 309 IVKVLLNEGAN---IEDHNEN-------------------GHTPLMEAASAGHVEVARVL 346
+ +LL+ GA+ + HN++ GH+ L A A + + L
Sbjct: 292 VCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHL 351
Query: 347 LDHGAGINTHSNEFKESALTLAC---YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
+N + E+AL A Y + LL GA+ KT E T L A
Sbjct: 352 SLEM--VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
Query: 404 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 463
H +V +++ A+VN + ++ L AA GH++ LL+ G + ++ +G+T
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTA 469
Query: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DI 520
L E V LL +G ++ E L A G V DI
Sbjct: 470 LQMG-----NENVQQLLQEGISLG--NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDI 522
Query: 521 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
E STPL A+ + +V+YLL GA+VHA G L AC GH +VA++L++ G
Sbjct: 523 EGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHG 582
Query: 581 ADLDKQEDMK--TILEGIDPAKHQVRVAFDACKLL 613
A ++ + K + E K+++ CKLL
Sbjct: 583 AVVNVADLWKFTPLHEAAAKGKYEI------CKLL 611
Score = 100 bits (250), Expect = 3e-21
Identities = 152/594 (25%), Positives = 221/594 (37%), Gaps = 131/594 (22%)
Query: 113 LDNPVLKTTSEIFLSSTAEGAD--LRTVDPETQARLEALLEAAAFADPEVLRRLTSSVSC 170
L +K ++ + GA+ +R D T L A L S
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187
Query: 171 ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESL 230
+E AL N H + + L A V V+ LL G V H ++ L
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--HAKDKGDL 245
Query: 231 LCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLH----- 283
+ L ACS G+YE+ + LL H + + TPL A+S +++ LLL +
Sbjct: 246 VPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304
Query: 284 ------------------------------------DADVN-------------SQSATG 294
+ADV T
Sbjct: 305 LLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364
Query: 295 NTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 351
TAL A A + I ++LL +GANI + + TPL A+ H +V V++ H A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
Query: 352 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 411
+N N +++L A Y GHL R LL G D + + TAL G+ V +
Sbjct: 425 KVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM----GNENVQQ 479
Query: 412 LLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAARE 470
LL + + N AD L AA G VE + L + N ++ TPL AA
Sbjct: 480 LLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY 536
Query: 471 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTP 527
+V LL GA+++A+ ++ L AC G EVA+ L+K GA + +L TP
Sbjct: 537 NRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
Query: 528 LMEASQEGHLELVKYLLASGA-----NVHATTAT---------------GDTALTYACEN 567
L EA+ +G E+ K LL GA N T GD AL A +
Sbjct: 596 LHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKK 655
Query: 568 G----------------------------------HTDVADVLLQAGADLDKQE 587
G + +VA+ LLQ GAD++ Q+
Sbjct: 656 GCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQD 709
Score = 95.1 bits (235), Expect = 2e-19
Identities = 91/321 (28%), Positives = 133/321 (41%), Gaps = 26/321 (8%)
Query: 147 EALLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGD 206
+ L E + + E R+L + E L +++ N + + L A
Sbjct: 479 QLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR 538
Query: 207 VNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLM 266
V+ V LL G V+ + G L ACS G+YE+A+ LL H V + + TPL
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAE-LLVKHGAVVNVADLWKFTPLH 597
Query: 267 AASSGGYLDIVKLLLLHDADVNSQSATGNT--------------------ALTYACAGGF 306
A++ G +I KLLL H AD ++ GNT AL A G
Sbjct: 598 EAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGC 657
Query: 307 VDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 365
+ VK L + + N D TPL AA ++EVA LL HGA +N
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
Query: 366 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 425
A Y GH+D+ L++ A T L EA G ++ LLL GA +
Sbjct: 718 NAASY-GHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQ 776
Query: 426 SFESPLTLAACGGHVELAALL 446
++PL L + +++ALL
Sbjct: 777 EGQTPLDLVSAD---DVSALL 794
Score = 70.9 bits (172), Expect = 3e-12
Identities = 64/215 (29%), Positives = 95/215 (44%), Gaps = 26/215 (12%)
Query: 398 LMEACMDGHVE-VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 456
L EAC +G VE V RL+ A +PL AA G ++ L++ GAN++
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 457 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 516
+D G PL A GH E+V LLL GA+ NA+ + T L A G +V L++
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQH 146
Query: 517 GAD---------IELGCSTP--------------LMEASQEGHLELVKYLLAS-GANVHA 552
GA+ L + P L+E+++ G+ E + LL N HA
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHA 206
Query: 553 TTATGDTALTYACENGHTDVADVLLQAGADLDKQE 587
+ T L A + +LLQ GAD+ ++
Sbjct: 207 SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKD 241
Score = 49.3 bits (116), Expect = 1e-05
Identities = 27/64 (42%), Positives = 40/64 (62%)
Query: 525 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
STPL A+ G ++V+YLL +GANV A G L AC GH +V ++LL+ GAD +
Sbjct: 59 STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118
Query: 585 KQED 588
+++
Sbjct: 119 ARDN 122
Score = 37.7 bits (86), Expect = 0.031
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 502 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVHATTATGDTA 560
C GG + A A A+ + L EA + G +E VK L+ N T T
Sbjct: 6 CAGGGAACAS----AAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTP 61
Query: 561 LTYACENGHTDVADVLLQAGADLDKQED 588
L +A G DV + LLQ GA++ ++D
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDD 89
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 140 bits (353), Expect = 3e-33
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
Query: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
Query: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 490
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
Query: 491 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 549
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
Query: 550 VHATTATGDTA 560
+ A AT TA
Sbjct: 419 IDAYIATHPTA 429
Score = 103 bits (258), Expect = 4e-22
Identities = 92/329 (27%), Positives = 148/329 (44%), Gaps = 45/329 (13%)
Query: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQE---------------------------HK 390
+E+A+ LA +GHLD + LL+AGA+ + H
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 391 TDEMH------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 444
D H TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
Query: 445 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 504
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIASKK 299
Query: 505 GFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA------- 555
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
Query: 556 --TGDTALTYACENGHTDVADVLLQAGAD 582
+AL +A N + ++LLQ GAD
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGAD 388
Score = 83.2 bits (204), Expect = 7e-16
Identities = 63/225 (28%), Positives = 105/225 (46%), Gaps = 5/225 (2%)
Query: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNMP 423
L A G + ++ +++ G + E L EA G V ++L + ++
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 424 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 483
E+ + LA C GH++ L++ GA + N TPL +A + E V +L+
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 484 ANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 540
A+ N + TAL + EV L+ GA +E + TPL A+Q G LE +
Sbjct: 181 ADTNHRCNRGW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
Query: 541 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
++L GA+++ + +AL AC+N H +V + LL GAD +K
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 7/167 (4%)
Query: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
Query: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Query: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
VK L+ A+ + G TAL + +V +L+ GA ++ +
Sbjct: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 127 bits (320), Expect = 2e-29
Identities = 89/304 (29%), Positives = 149/304 (49%), Gaps = 5/304 (1%)
Query: 282 LHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVE 341
L + DVN + G L A G + I+++L+ G+ I+ ++ G + AA GHV+
Sbjct: 367 LSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVD 426
Query: 342 VARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEA 401
+ L ++ ++ ++ E AL +A GH D+ + L G++ + E T L A
Sbjct: 427 TLKFLSENKCPLDV-KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
Query: 402 CMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 461
G+ VA+ L ++G VN+ E+PL A+ G+ ++ L E GA+L + +G+
Sbjct: 486 AWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGH 545
Query: 462 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 521
L A R E++ LL+QG ++ Q + T L +AC G + L +A +++
Sbjct: 546 IALHLAVRRCQMEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIVVALCEANCNLD 604
Query: 522 LGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
+ TPL A+ G L++V+YL GA+V A T G TA A H VA +L +
Sbjct: 605 ISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664
Query: 579 AGAD 582
D
Sbjct: 665 LRKD 668
Score = 117 bits (292), Expect = 4e-26
Identities = 82/269 (30%), Positives = 135/269 (50%), Gaps = 5/269 (1%)
Query: 319 NIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVR 378
++ N++G PL+ AA G++++ ++L+ G+ I+ ++ +A+ A GH+D ++
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ-DKGGSNAVYWAARHGHVDTLK 429
Query: 379 FLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGG 438
FL E + K AL A GH +VA+LL G+ N+ E+PL AA G
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHG 489
Query: 439 HVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
+ +A L E G N+ N EG TPL+ A+ G+ ++V L GA++NA ++ AL
Sbjct: 490 YYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNA-CDKDGHIAL 548
Query: 499 TLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTA 555
LA EV L+ G ++ +TPL A ++G++ +V L + N+ +
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNK 608
Query: 556 TGDTALTYACENGHTDVADVLLQAGADLD 584
G T L A NG DV L GA ++
Sbjct: 609 YGRTPLHLAANNGILDVVRYLCLMGASVE 637
Score = 116 bits (290), Expect = 7e-26
Identities = 94/330 (28%), Positives = 154/330 (46%), Gaps = 5/330 (1%)
Query: 196 RSLAEACSDGDVNAVRKLLDE--GRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 253
+++ A +D +V ++ LL VN+ + G L +A G ++ Q+L+ + +
Sbjct: 346 KAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRI 405
Query: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
D +KG + A+ G++D +K L + ++ + +G AL A G D+ ++L
Sbjct: 406 -DVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464
Query: 314 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 373
+ G+N ++ TPL AA G+ VA+ L + G +N + E E+ L A +G+
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNRE-GETPLLTASARGY 523
Query: 374 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 433
D+V L E GAD + H AL A +EV + LL G V+ +PL +
Sbjct: 524 HDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV 583
Query: 434 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 493
A G++ + L E NL+ N G TPL AA G ++V L GA++ A T +
Sbjct: 584 ACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTD- 642
Query: 494 QETALTLACCGGFSEVADFLIKAGADIELG 523
+TA LA VA L + D G
Sbjct: 643 GKTAEDLARSEQHEHVAGLLARLRKDTHRG 672
Score = 84.3 bits (207), Expect = 3e-16
Identities = 59/193 (30%), Positives = 98/193 (50%), Gaps = 4/193 (2%)
Query: 398 LMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN 457
L+ A G++++ +LL+ G+++++ + + AA GHV+ L E L+ +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKD 442
Query: 458 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 517
G L AAR GH ++ LL + G+N N Q +E +ET L A G+ VA L +AG
Sbjct: 443 KSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE-EETPLHCAAWHGYYSVAKALCEAG 501
Query: 518 ADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 574
++ + TPL+ AS G+ ++V+ L GA+++A G AL A +V
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561
Query: 575 VLLQAGADLDKQE 587
LL G +D Q+
Sbjct: 562 TLLSQGCFVDYQD 574
Score = 46.6 bits (109), Expect = 7e-05
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 7/110 (6%)
Query: 485 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVK 541
++N + L A CG ++ LIK G+ I++ G S + A++ GH++ +K
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNI-QILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLK 429
Query: 542 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD---LDKQED 588
+L + + +G+ AL A GH DVA +L G++ DK+E+
Sbjct: 430 FLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEE 479
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,440,681
Number of Sequences: 37866
Number of extensions: 1166941
Number of successful extensions: 18546
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 499
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 6985
Number of HSP's gapped (non-prelim): 4647
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.