Guide to the Human Genome
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Search of human proteins with 46519147

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
         (2542 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...  5035   0.0  
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                   4990   0.0  
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...  2855   0.0  
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...  1518   0.0  
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...  1167   0.0  
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...  1138   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   257   9e-68
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       237   1e-61
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        237   1e-61
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        237   1e-61
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       226   2e-58
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        226   2e-58
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        226   2e-58
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        226   2e-58
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        226   2e-58
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        225   5e-58
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   184   1e-45
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   180   2e-44
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  169   4e-41
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   168   7e-41
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   167   1e-40
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   164   8e-40
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    162   5e-39
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   159   3e-38
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   158   6e-38
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    158   6e-38
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   149   4e-35
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   149   4e-35
gi|67906195 ankyrin repeat and sterile alpha motif domain contai...   148   6e-35
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho...   140   2e-32

>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 2542

 Score = 5035 bits (13061), Expect = 0.0
 Identities = 2542/2542 (100%), Positives = 2542/2542 (100%)

Query: 1    MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
            MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1    MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61   GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
            GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61   GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121  TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
            TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121  TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181  CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
            CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181  CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241  LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
            LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241  LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301  QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
            QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301  QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361  GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
            GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361  GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
            ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481  EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
            EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481  EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541  EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
            EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG
Sbjct: 541  EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 601  GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
            GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD
Sbjct: 601  GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660

Query: 661  PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
            PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT
Sbjct: 661  PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720

Query: 721  HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
            HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE
Sbjct: 721  HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780

Query: 781  ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
            ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK
Sbjct: 781  ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840

Query: 841  VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
            VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD
Sbjct: 841  VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900

Query: 901  TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
            TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI
Sbjct: 901  TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960

Query: 961  VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
            VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC
Sbjct: 961  VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020

Query: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
            LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK
Sbjct: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080

Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
            IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140

Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
            LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200

Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
            GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260

Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
            LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320

Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380

Query: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
            VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS
Sbjct: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440

Query: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
            REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ
Sbjct: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500

Query: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
            EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI
Sbjct: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560

Query: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
            LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV
Sbjct: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620

Query: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
            NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP
Sbjct: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680

Query: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
            KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE
Sbjct: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740

Query: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
            RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA
Sbjct: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800

Query: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
            ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA
Sbjct: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860

Query: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
            AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV
Sbjct: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920

Query: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
            LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT
Sbjct: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980

Query: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
            STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN
Sbjct: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040

Query: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
            LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS
Sbjct: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100

Query: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
            EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF
Sbjct: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160

Query: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
            VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS
Sbjct: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220

Query: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
            QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST
Sbjct: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280

Query: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
            SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS
Sbjct: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340

Query: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
            NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI
Sbjct: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400

Query: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
            WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA
Sbjct: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460

Query: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
            SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD
Sbjct: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520

Query: 2521 AQQIWPGTWAPHIGNMHLKYVN 2542
            AQQIWPGTWAPHIGNMHLKYVN
Sbjct: 2521 AQQIWPGTWAPHIGNMHLKYVN 2542


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score = 4990 bits (12943), Expect = 0.0
 Identities = 2523/2523 (100%), Positives = 2523/2523 (100%)

Query: 1    MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
            MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1    MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61   GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
            GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61   GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121  TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
            TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121  TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181  CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
            CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181  CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241  LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
            LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241  LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301  QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
            QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301  QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361  GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
            GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361  GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
            ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421  ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481  EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
            EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481  EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541  EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
            EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG
Sbjct: 541  EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600

Query: 601  GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
            GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD
Sbjct: 601  GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660

Query: 661  PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
            PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT
Sbjct: 661  PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720

Query: 721  HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
            HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE
Sbjct: 721  HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780

Query: 781  ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
            ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK
Sbjct: 781  ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840

Query: 841  VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
            VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD
Sbjct: 841  VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900

Query: 901  TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
            TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI
Sbjct: 901  TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960

Query: 961  VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
            VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC
Sbjct: 961  VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020

Query: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
            LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK
Sbjct: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080

Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
            IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140

Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
            LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200

Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
            GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260

Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
            LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320

Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380

Query: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
            VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS
Sbjct: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440

Query: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
            REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ
Sbjct: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500

Query: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
            EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI
Sbjct: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560

Query: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
            LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV
Sbjct: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620

Query: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
            NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP
Sbjct: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680

Query: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
            KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE
Sbjct: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740

Query: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
            RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA
Sbjct: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800

Query: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
            ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA
Sbjct: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860

Query: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
            AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV
Sbjct: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920

Query: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
            LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT
Sbjct: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980

Query: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
            STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN
Sbjct: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040

Query: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
            LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS
Sbjct: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100

Query: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
            EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF
Sbjct: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160

Query: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
            VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS
Sbjct: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220

Query: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
            QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST
Sbjct: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280

Query: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
            SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS
Sbjct: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340

Query: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
            NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI
Sbjct: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400

Query: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
            WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA
Sbjct: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460

Query: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
            SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD
Sbjct: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520

Query: 2521 AQQ 2523
            AQQ
Sbjct: 2521 AQQ 2523


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score = 2855 bits (7402), Expect = 0.0
 Identities = 1584/2576 (61%), Positives = 1867/2576 (72%), Gaps = 133/2576 (5%)

Query: 42   RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
            RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78   RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100  ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                  VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123  DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154  GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
            GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183  GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 214  SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
            S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243  SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 274  TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
            TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303  TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 334  HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
            HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363  HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 394  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
            AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423  AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 454  AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
            AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483  AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 514  CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
            CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543  CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 574  YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
            YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 603  YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662

Query: 634  NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
            NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 663  NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722

Query: 694  VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQ 753
            +LS P  DV+QL PPS D ++ PRVP   L MVVPPQEPD+     +  L    K  SKQ
Sbjct: 723  LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQ 782

Query: 754  KSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRI-SAIEK-AQLKSLELIQGEP 811
            KSSS   A+   +  +   Q  E IVEE +GKL EL QRI  AIEK AQL+SLEL   + 
Sbjct: 783  KSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQ 842

Query: 812  LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQ 871
            L K+KIEEL K REEQ+QKK+KIL+ELQKVER+LQ+KTQQQ  K+YLE K Q+  +   Q
Sbjct: 843  LTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQ 902

Query: 872  Q--CSHRGVF-PEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQ 928
            Q  C H G+  P G G+  L E  ++ L QVD +L K    D+ QQ   +A Q+ F P+Q
Sbjct: 903  QQSCQHLGLLTPVGVGE-QLSEGDYARLQQVDPVLLK----DEPQQ---TAAQMGFAPIQ 954

Query: 929  PLSSPQC--NFSSDLGSNG-TNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMV 985
            PL+ PQ     +  L      N  ELQ V   Q ++GQ Q+A  G  QG+L +   GLMV
Sbjct: 955  PLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLA--GLGQGILTETQQGLMV 1012

Query: 986  ATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQS-MPPVYPS 1044
            A+PAQTL DTLDD++AAVS R    SN+ + +      +  + T S + S S M P+YP+
Sbjct: 1013 ASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 1072

Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
            +DIDA TESNHDTALTLACAGGHEELV  L+ R A IEHRDKKGFTPLILAATAGHVGVV
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132

Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
            EILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLLARGANKEHRNVSDYTPLSLAAS
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
            GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH  AVKLLLDMGSDINAQIETNR
Sbjct: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
            NTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
            APPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRNKKGNTPLWLA+NGGH DVVQLL
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
            VQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVNQFPSD ECMRYIATITDKE+LK
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLK 1432

Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKK 1464
            KCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK REESR+ ALAAKREKRKEKR+KKK
Sbjct: 1433 KCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKK 1492

Query: 1465 EEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATF 1524
            EEQ+RK EE E  K KEN EL   +++E+   + E EV  EPPSATTTTTIGISAT  T 
Sbjct: 1493 EEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTL 1551

Query: 1525 TNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
                G KR N +TT S+ RKN+KNK   TP    +I  +    L    +   K+NGE + 
Sbjct: 1552 AGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFDD---PLPISYSQPEKVNGESKS 1605

Query: 1585 GGAGGNSDSDNLDSTDCNSESSSGGKSQELN------FVMDVNSSKYPSLLLHSQEEKTS 1638
                 + DSDN+  + C+ ESS+   S++ +          V+S K PS+L+   +E+  
Sbjct: 1606 SSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERK 1665

Query: 1639 TATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVR 1695
            + + K   +L     E T NSLST  K+   PLSSPN KL + SPKRGQKREEGWKEVVR
Sbjct: 1666 SVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVR 1725

Query: 1696 RSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRYA 1755
            RSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DKQKDK G+R+ITIRGGTESTR A
Sbjct: 1726 RSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQA 1785

Query: 1756 VQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSKNAFPLGAPTLV 1815
             QLINALI+DP KE+++LIPKN ++    + S ++   S   TT A++ +   +   T+ 
Sbjct: 1786 TQLINALIKDPDKEIDELIPKNRLK----SSSANSKIGSSAPTTTAANTSLMGIKMTTVA 1841

Query: 1816 ---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPVSLPLAYPHPHF--ALLAAQTMQ 1865
               TSQ  T  T         +K  KN   NVR  FPVSLPLAYP P F  ALLAAQT Q
Sbjct: 1842 LSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQ 1901

Query: 1866 QIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVLPSES 1925
            QIR PRLPM  FGGTF P+ +TWGPFPVRP++P    +SPK +   R  NQN +     S
Sbjct: 1902 QIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNS 1961

Query: 1926 AGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTS-PPATVISSVTSTCS 1984
            AG  T+S   T SS  +         + +  SVR+QLF  V KTS    T +++  S  +
Sbjct: 1962 AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNN 2021

Query: 1985 SLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPM 2038
            + P+ ++ P+ + +      +P++  P +       +  ++  SA P    KV++  +  
Sbjct: 2022 TAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASP---NKVASSSEQE 2078

Query: 2039 ANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSM---- 2094
            A       T N+   ++S++ G+   H S+   P  S +QE   P   S + P  +    
Sbjct: 2079 AGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTV 2137

Query: 2095 -PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQ-------PRGSFYSM 2146
             P A++S P  +  T+P         T  +PQ  +  P+ + +M+       P G+    
Sbjct: 2138 PPLATSSAPVAVPSTAP--------VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPH 2189

Query: 2147 VPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGP 2206
              +A++     ++   N +    P   P++VQL S ++  +  Q  ++PANK + P F  
Sbjct: 2190 KNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSA 2247

Query: 2207 ATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNS 2266
               F  FS+LF++S   A+  WG   +SS+   ++  + +S++L NS   H      D S
Sbjct: 2248 PLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLH----QSDTS 2303

Query: 2267 KAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASF-SGIPGTRVFLQGPAPVGTP- 2324
            KAPGFRPP QR + SP G+ ++D    S + SS  L +F S I G +++  G    G P 
Sbjct: 2304 KAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPA 2363

Query: 2325 --SFNRQHFSP----HPWTSASNSSTS------------APPT--LGQPKGVSASQDRKI 2364
              +FNRQHFSP     P +SASN S++            AP +  LG  K  + SQDRK+
Sbjct: 2364 AANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKV 2423

Query: 2365 PPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGNHP 2424
            P PIGTER ARIRQ G+ A +  G++    VGHSGIWSF     ++    W    MGN  
Sbjct: 2424 PVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPM 2483

Query: 2425 MHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSK--GLPISMYGGTIIPS 2482
            +H+ +SDP  FSQHQ MERD +G+V PS  FHQ + +G++DF K  G+P S+YG  +IP 
Sbjct: 2484 IHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPP 2543

Query: 2483 HPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHL 2538
               + D  GGP+FNG H  DP+WN +IK++ +STE    Q +W G WAPH+ ++H+
Sbjct: 2544 VAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWAPHMNSVHM 2599


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score = 1518 bits (3930), Expect = 0.0
 Identities = 869/1638 (53%), Positives = 1080/1638 (65%), Gaps = 97/1638 (5%)

Query: 964  PQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTP 1023
            P++ +      +  QEPD      P   +  TL     AVS R    SN+ + +      
Sbjct: 745  PRVPVQALPMVVPPQEPD-----KPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASIS 799

Query: 1024 ESCSQTTSNVASQS-MPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE 1082
            +  + T S + S S M P+YP++DIDA TESNHDTALTLACAGGHEELV  L+ R A IE
Sbjct: 800  QPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 859

Query: 1083 HRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142
            HRDKKGFTPLILAATAGHVGVVEILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLL
Sbjct: 860  HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919

Query: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
            ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH
Sbjct: 920  ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979

Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
              AVKLLLDMGSDINAQIETNRNTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLM
Sbjct: 980  TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLM 1039

Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
            EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRN
Sbjct: 1040 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1099

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
            KKGNTPLWLA+NGGH DVVQLLVQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVN
Sbjct: 1100 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159

Query: 1383 QFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSRE 1442
            QFPSD ECMRYIATITDKE+LKKCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK RE
Sbjct: 1160 QFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLRE 1219

Query: 1443 ESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEV 1502
            ESR+ ALAAKREKRKEKR+KKKEEQ+RK EE E  K KEN EL   +++E+   + E EV
Sbjct: 1220 ESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEV 1278

Query: 1503 PIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562
              EPPSATTTTTIGISAT  T     G KR N +TT S+ RKN+KNK   TP    +I  
Sbjct: 1279 LTEPPSATTTTTIGISATWTTLAGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFD 1335

Query: 1563 EQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN------F 1616
            +    L    +   K+NGE +      + DSDN+  + C+ ESS+   S++ +       
Sbjct: 1336 D---PLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVV 1392

Query: 1617 VMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNI 1673
               V+S K PS+L+   +E+  + + K   +L     E T NSLST  K+   PLSSPN 
Sbjct: 1393 TTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNG 1452

Query: 1674 KLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDK 1733
            KL + SPKRGQKREEGWKEVVRRSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DK
Sbjct: 1453 KLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDK 1512

Query: 1734 QKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFS 1793
            QKDK G+R+ITIRGGTESTR A QLINALI+DP KE+++LIPKN ++    + S ++   
Sbjct: 1513 QKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLK----SSSANSKIG 1568

Query: 1794 SGVGTTAASSKNAFPLGAPTLV---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPV 1845
            S   TT A++ +   +   T+    TSQ  T  T         +K  KN   NVR  FPV
Sbjct: 1569 SSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPV 1628

Query: 1846 SLPLAYPHPHF--ALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNS 1903
            SLPLAYP P F  ALLAAQT QQIR PRLPM  FGGTF P+ +TWGPFPVRP++P    +
Sbjct: 1629 SLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATN 1688

Query: 1904 SPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLF 1963
            SPK +   R  NQN +     SAG  T+S   T SS  +         + +  SVR+QLF
Sbjct: 1689 SPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLF 1748

Query: 1964 ACVPKTS-PPATVISSVTSTCSSLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQ 2016
              V KTS    T +++  S  ++ P+ ++ P+ + +      +P++  P +       + 
Sbjct: 1749 VTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNS 1808

Query: 2017 KMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSN 2076
             ++  SA P    KV++  +  A       T N+   ++S++ G+   H S+   P  S 
Sbjct: 1809 PLDCGSASP---NKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSV 1864

Query: 2077 TQEEAQPSSVSDLSPMSM-----PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAP 2131
            +QE   P   S + P  +     P A++S P  +  T+P         T  +PQ  +  P
Sbjct: 1865 SQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP--------VTYPMPQTPMGCP 1916

Query: 2132 RVSHRMQ-------PRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVN 2184
            + + +M+       P G+      +A++     ++   N +    P   P++VQL S ++
Sbjct: 1917 QPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLS 1974

Query: 2185 IMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFT 2244
              +  Q  ++PANK + P F     F  FS+LF++S   A+  WG   +SS+   ++  +
Sbjct: 1975 TQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLS 2034

Query: 2245 VQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLAS 2304
             +S++L NS   H      D SKAPGFRPP QR + SP G+ ++D    S + SS  L +
Sbjct: 2035 GKSSYLPNSDPLH----QSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGN 2090

Query: 2305 F-SGIPGTRVFLQGPAPVGTP---SFNRQHFSP----HPWTSASNSSTS----------- 2345
            F S I G +++  G    G P   +FNRQHFSP     P +SASN S++           
Sbjct: 2091 FASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPS 2150

Query: 2346 -APPT--LGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWS 2402
             AP +  LG  K  + SQDRK+P PIGTER ARIRQ G+ A +  G++    VGHSGIWS
Sbjct: 2151 PAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWS 2210

Query: 2403 FGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASG 2462
            F     ++    W    MGN  +H+ +SDP  FSQHQ MERD +G+V PS  FHQ + +G
Sbjct: 2211 FEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAG 2270

Query: 2463 FVDFSK--GLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
            ++DF K  G+P S+YG  +IP    + D  GGP+FNG H  DP+WN +IK++ +STE   
Sbjct: 2271 YMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNG 2330

Query: 2521 AQQIWPGTWAPHIGNMHL 2538
             Q +W G WAPH+ ++H+
Sbjct: 2331 PQTVWTGPWAPHMNSVHM 2348



 Score = 1158 bits (2995), Expect = 0.0
 Identities = 591/701 (84%), Positives = 633/701 (90%), Gaps = 23/701 (3%)

Query: 42  RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
           RT R    +  +S   +SGGGG G G GGG               GGG  ++ S+E+E  
Sbjct: 78  RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122

Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
                 VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182

Query: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
           GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242

Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
           S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL  GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
           HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
           AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
           AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542

Query: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
           CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602

Query: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
           YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662

Query: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
           NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722

Query: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDR 734
           +LS P  DV+QL PPS D ++ PRVP   L MVVPPQEPD+
Sbjct: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDK 763



 Score =  213 bits (542), Expect = 2e-54
 Identities = 138/365 (37%), Positives = 198/365 (54%), Gaps = 38/365 (10%)

Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
            D++A + S  +TALT ACAGG+ ++V VL+   A IE  ++ G TPL+ A +AGHV V  
Sbjct: 326  DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384

Query: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
            +LL+ G  I   S   K++ L+LAC  G  E+V  LL  GA++EH+    +T L  A   
Sbjct: 385  LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444

Query: 1166 GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 1194
            G+V + ++LL++GA++N                            G+ L      G +PL
Sbjct: 445  GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504

Query: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
            M AA  GH   V LLL  G++INAQ E  + TALTLAC  G  EV   L+   A++E   
Sbjct: 505  MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
                TPLMEAA  G+ E+ + LL  GA+V+A    ++ DTALT A + GH    ++L+  
Sbjct: 565  S---TPLMEAAQEGHLELVKYLLAAGANVHA--TTATGDTALTYACENGHTDVADVLLQA 619

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD-AADNRKITPLMSAFRKGHVKV 1373
            GA ++  ++ G TPL  A+  GH   VQ L+  GA+V+    N   T L  A   GH+ V
Sbjct: 620  GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679

Query: 1374 VQYLV 1378
            V+ L+
Sbjct: 680  VELLL 684



 Score =  211 bits (538), Expect = 6e-54
 Identities = 126/336 (37%), Positives = 194/336 (57%), Gaps = 10/336 (2%)

Query: 297  DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
            D+++Q+ + + TALT ACAGG  ++V+ LL  GA+IE  ++ G TPL+ AA+AGHV V  
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882

Query: 356  VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
            +LLD+GA I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A   
Sbjct: 883  ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942

Query: 416  GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472
            G+V + ++LL++GA++N    S    SPL LAA  GH     LL++ G+++  ++     
Sbjct: 943  GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002

Query: 473  TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
            T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+ 
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 533  L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
                     T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121

Query: 588  LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
            +QAGAD++       TPLM A R GH+  V++L+ +
Sbjct: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score =  207 bits (526), Expect = 1e-52
 Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)

Query: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
            +L  AC+ G    V+ LL+ G S+    ++G + L LA +AG+  + ++LL   A++E +
Sbjct: 835  ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
              +   TPL  A SGG  ++V+LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 895  SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954

Query: 328  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
            GA I     ++ G +PLM AA  GH    ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 955  GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014

Query: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AA  GH +   LLI RGA+++  N +G TPL  AA  GH ++V LL+  GA+++A    
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
                                             TPLM A ++GH+++V+YL+
Sbjct: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155



 Score =  198 bits (503), Expect = 6e-50
 Identities = 139/450 (30%), Positives = 232/450 (51%), Gaps = 16/450 (3%)

Query: 942  GSNGTNSLELQKVSGNQQIVGQPQIAITGHD--QGLLVQEPDGLMVATPA-----QTLTD 994
            G++  NS E +     ++ V + +  I   D  +  +++    L+++  A     +T+  
Sbjct: 110  GTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDP 169

Query: 995  TLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESN 1054
                 + A+      G  S++       PE   + TS+V+            + A + +N
Sbjct: 170  ETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTAN 229

Query: 1055 ----HDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
                 + +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL  
Sbjct: 230  AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 289

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
              ++E +  +   TPL  A +GG  ++V LLLA  A+   ++ +  T L+ A +GGYV++
Sbjct: 290  HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDV 349

Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
            +K+LL +GA I     ++ G +PLM A   GHV   +LLL+ G+ IN      + +ALTL
Sbjct: 350  VKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL 407

Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
            AC++G  E+V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    
Sbjct: 408  ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--AD 465

Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
            S ++ LT+AA  GH +   LLI RGA ++  N +G TPL  A+  GH ++V LL+  GA+
Sbjct: 466  SFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525

Query: 1351 VDA-ADNRKITPLMSAFRKGHVKVVQYLVK 1379
            ++A  +  + T L  A   G ++V  +L+K
Sbjct: 526  INAQTEETQETALTLACCGGFLEVADFLIK 555



 Score =  186 bits (473), Expect = 2e-46
 Identities = 191/699 (27%), Positives = 304/699 (43%), Gaps = 108/699 (15%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGE-SLLCLACSAGYYELAQVLLAMHANVEDR 267
            L +A   G V  V+ L+ +G +VN  T   + ++L LAC+ G+  + ++LLA  A+   R
Sbjct: 634  LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT-------YACAGGFVDI 320
               G  T L+ A+ GG+  +V  LL +  ++ S      T LT        A       +
Sbjct: 694  LKDGS-TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752

Query: 321  VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 380
              V+  +  +    N     P+   A +G          H    +    +    +  ++ 
Sbjct: 753  PMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIIS- 811

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
                       +    D + +T+  H TAL  AC  GH E+ + LL+ GA +        
Sbjct: 812  -----PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF 866

Query: 440  SPLTLAACGGHVELAALLIERGANLEEVNDEGY-TPLMEAAREGHEEMVALLLAQGANIN 498
            +PL LAA  GHV +  +L++ GA++E  ++    TPL  A   G +E+V LLLA+GAN  
Sbjct: 867  TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN-K 925

Query: 499  AQTEETQETALTLACCGGFSEVADFLIKAGADI------ELGCSTPLMEASQEGHLELVK 552
                 +  T L+LA  GG+  +   L+ AGA+I      +LG S PLM A+  GH   VK
Sbjct: 926  EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-PLMLAAMNGHTAAVK 984

Query: 553  YLLASGANVHATTATG-DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
             LL  G++++A   T  +TALT AC  G T+V  +LL   A++EH ++ G TPLM+AA  
Sbjct: 985  LLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1044

Query: 612  GHLCTVQFLISKGANVN-------RATA---------------------------NNDHT 637
            G+    + L+ KGA+VN       R TA                              +T
Sbjct: 1045 GYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1104

Query: 638  VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697
             + LA  GGHL VV+LL+  GAD         T L+ A + GH  VV YL+         
Sbjct: 1105 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV--------- 1155

Query: 698  PTTDVSQLPPPSQDQSQVPRVPTHT------LAMVVPPQEPDRTSQENSPALLGVQKGTS 751
               +V+Q P  S+    +  +          L M    Q  DR + E             
Sbjct: 1156 --KEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE------------- 1200

Query: 752  KQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEP 811
              K++S+ + + DL                   KL E  +R++   K + +  +  + + 
Sbjct: 1201 ANKNASILLEELDL------------------EKLREESRRLALAAKREKRKEKRRKKKE 1242

Query: 812  LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQ 850
              + K+EE++   +E  + +    KE  KVE + ++ T+
Sbjct: 1243 EQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTE 1281



 Score =  175 bits (443), Expect = 6e-43
 Identities = 129/360 (35%), Positives = 192/360 (53%), Gaps = 20/360 (5%)

Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
            +++  T +N  T L+LACAGGH  +V +L+A  A   HR K G T LI AA  GH  VV 
Sbjct: 655  NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714

Query: 1106 ILLDKGGDI--EAQSERTKDTP----LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
             LLD   ++      + T+ TP    L+ A     Q +  ++  +  +K   NV+   P+
Sbjct: 715  YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774

Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGS-KLGISPLMLAAMNGHV-PAVKLLLDMGSDIN 1217
               A  G          A A  N+ T S    IS       +  + P+  L +    DI+
Sbjct: 775  RNKAVSG---------RASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825

Query: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
            AQ E+N +TALTLAC  G  E+V  LL+R A++EHR K G TPL+ AA+ G+  V  +LL
Sbjct: 826  AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885

Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
            D GAD+ A     ++DT L++A   G  +  ELL+ RGA+ + RN    TPL LA++GG+
Sbjct: 886  DNGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 944

Query: 1338 FDVVQLLVQAGADVDAADNRK--ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA 1395
             +++++L+ AGA++++    K  I+PLM A   GH   V+ L+   +   + IE  R  A
Sbjct: 945  VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA 1004



 Score =  161 bits (407), Expect = 9e-39
 Identities = 102/265 (38%), Positives = 144/265 (54%), Gaps = 34/265 (12%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            ++ LTLA  GGH EL ++LI R A +E  + +G+TPL+ AA  GH  +V +LL +G +I 
Sbjct: 468  ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
            AQ+E T++T L+LAC GG  EV D L+  GA+ E   +   TPL  AA  G++ ++K LL
Sbjct: 528  AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584

Query: 1176 NAGAEINSRTG-------------------------------SKLGISPLMLAAMNGHVP 1204
             AGA +++ T                                S+ G +PLM AA  GHV 
Sbjct: 585  AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644

Query: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
             V+ L+  G+++N     N +T L+LAC  G   VV LLL   A+  HR K G T L+EA
Sbjct: 645  TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704

Query: 1265 ASGGYAEVGRVLLDKGADVNAPPVP 1289
            A GG+  V   LLD   ++ + P P
Sbjct: 705  AKGGHTSVVCYLLDYPNNLLSAPPP 729



 Score =  154 bits (388), Expect = 1e-36
 Identities = 114/333 (34%), Positives = 161/333 (48%), Gaps = 11/333 (3%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T +  DTALT AC  GH ++  VL+   A +EH  + G TPL+ AA AGHV  V+ L+ K
Sbjct: 593  TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
            G ++   +     T LSLAC+GG   VV+LLLA GA+  HR     T L  AA GG+ ++
Sbjct: 653  GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712

Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
            +  LL+    + S     +         +N         L M        +   N A TL
Sbjct: 713  VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772

Query: 1231 ----ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
                    GRA  +S            A +   P     S   +    + +    D++A 
Sbjct: 773  PIRNKAVSGRASAMS-----NTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA- 826

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
               S+ DTALT+A   GH +  + L+ RGA I+ R+KKG TPL LA+  GH  VV++L+ 
Sbjct: 827  QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886

Query: 1347 AGADVDAADNR-KITPLMSAFRKGHVKVVQYLV 1378
             GAD++A   R K TPL  A   G  +VV+ L+
Sbjct: 887  NGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919



 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 6/165 (3%)

Query: 167  ADPEVLRRLTSSVSC--ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKL 224
            A  E  R    +++C     E  + L   KA   H A +     L EA S G     R L
Sbjct: 995  AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1053

Query: 225  LDEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
            LD+G  VN        ++ L +A   G+Y+  ++L+   A+++ R  KG+ TPL  A++G
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAANG 1112

Query: 283  GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            G+LD+V+LL+   ADV++      T L  A   G V +V+ L+ E
Sbjct: 1113 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157



 Score = 33.1 bits (74), Expect = 3.6
 Identities = 31/146 (21%), Positives = 55/146 (37%), Gaps = 18/146 (12%)

Query: 1542 NRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDC 1601
            + K K+N+T   P ++           +   +D +   G   GGG GG   S N    + 
Sbjct: 71   HHKAKRNRTCRPPSSSE----------SSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120

Query: 1602 NSESSSGGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATS--------KTQTRLEGEVT 1653
            + +      S+  +F++D +  + P L   S+   + TA          +TQ RLE  + 
Sbjct: 121  DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180

Query: 1654 PNSLSTSYKTVSLPLSSPNIKLNLTS 1679
               +           + P +   LTS
Sbjct: 181  AAGIGKLSTADGKAFADPEVLRRLTS 206


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score = 1167 bits (3020), Expect = 0.0
 Identities = 601/619 (97%), Positives = 604/619 (97%), Gaps = 1/619 (0%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 599

Query: 601 GRTPLMKAARAGHLCTVQF 619
            +T L     A H   V F
Sbjct: 600 MKTILEGIDPAKHQVRVAF 618



 Score =  248 bits (632), Expect = 7e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267

Query: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387

Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447

Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507

Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563

Query: 697 VPTT 700
              T
Sbjct: 564 TTAT 567



 Score =  202 bits (514), Expect = 3e-51
 Identities = 146/438 (33%), Positives = 228/438 (52%), Gaps = 49/438 (11%)

Query: 981  DGLMVATP------AQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA 1034
            DG   A P        +++  LD+  AA++      S+++ Q       E+CS    N  
Sbjct: 162  DGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAV 221

Query: 1035 SQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG-FTPLI 1093
             + +        ++ HTE   ++ L LAC+ G+ EL  VL+A  A +E R  KG  TPL+
Sbjct: 222  RKLLDE---GRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLM 277

Query: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153
             A++ G++ +V++LL    D+ +QS  T +T L+ AC+GG  ++V +LL  GAN E  N 
Sbjct: 278  AASSGGYLDIVKLLLLHDADVNSQSA-TGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336

Query: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTG----SKLGIS----------------- 1192
            + +TPL  AAS G+V + ++LL+ GA IN+ +     S L ++                 
Sbjct: 337  NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396

Query: 1193 -----------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
                        LM A M+GHV   +LLLD G+ +N   ++  +  LTLA   G  E+ +
Sbjct: 397  DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP-LTLAACGGHVELAA 455

Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
            LL++R AN+E     G TPLMEAA  G+ E+  +LL +GA++NA     +++TALT+A  
Sbjct: 456  LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ-TEETQETALTLACC 514

Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
             G  +  + LI  GA I++     +TPL  AS  GH ++V+ L+ +GA+V A      T 
Sbjct: 515  GGFSEVADFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571

Query: 1362 LMSAFRKGHVKVVQYLVK 1379
            L  A   GH  V   L++
Sbjct: 572  LTYACENGHTDVADVLLQ 589



 Score =  201 bits (512), Expect = 6e-51
 Identities = 146/475 (30%), Positives = 238/475 (50%), Gaps = 48/475 (10%)

Query: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148

Query: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA---SQSMPPVYPSVDIDAHTESNH 1055
            L+ A       G  S++       PE   + TS+V+    ++   +      ++H     
Sbjct: 149  LLEAAGI----GKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204

Query: 1056 DT-ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDI 1114
            DT +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++
Sbjct: 205  DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264

Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
            E +  +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+L
Sbjct: 265  EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324

Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
            LN GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++
Sbjct: 325  LNEGANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382

Query: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
            G  ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++
Sbjct: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFES 440

Query: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1354
             LT+AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A 
Sbjct: 441  PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500

Query: 1355 DNRK-------------------------------ITPLMSAFRKGHVKVVQYLV 1378
                                                TPLM A ++GH+++V+YL+
Sbjct: 501  TEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555



 Score =  191 bits (486), Expect = 6e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 295  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354

Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 355  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 415  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 471

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 472  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 532  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586

Query: 1344 LVQAGADVDAADNRK 1358
            L+QAGAD+D  ++ K
Sbjct: 587  LLQAGADLDKQEDMK 601



 Score =  167 bits (423), Expect = 1e-40
 Identities = 99/248 (39%), Positives = 136/248 (54%), Gaps = 5/248 (2%)

Query: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
           +C      AAL   +  N           L EA  +G    V  LL +G ++N  TEE  
Sbjct: 180 SCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG- 238

Query: 506 ETALTLACCGGFSEVADFLIKAGADIE----LGCSTPLMEASQEGHLELVKYLLASGANV 561
           E+ L LAC  G+ E+A  L+   A++E     G  TPLM AS  G+L++VK LL   A+V
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298

Query: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
           ++ +ATG+TALTYAC  G  D+  VLL  GA++E  +E G TPLM+AA AGH+   + L+
Sbjct: 299 NSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL 358

Query: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
             GA +N  +     + ++LAC  GHL +V  LL  GAD  H+  +  T L+EA   GH 
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418

Query: 682 NVVSYLLD 689
            V   LLD
Sbjct: 419 EVARLLLD 426



 Score =  155 bits (391), Expect = 6e-37
 Identities = 102/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)

Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
            L+ ACS G    V  LL  G +         + L LA S GY  + ++LL   A +  R 
Sbjct: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 267

Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
            G+K  I+PLM A+  G++  VKLLL   +D+N+Q  T  NTALT AC  G  ++V +LL+
Sbjct: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 326

Query: 1246 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305
              AN+E   + G TPLMEAAS G+ EV RVLLD GA +N       +++ALT+A  KGH 
Sbjct: 327  EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 385

Query: 1306 ---------------------------------KFCELLIHRGAHIDVRNKKGNTPLWLA 1332
                                             +   LL+  GA +++      +PL LA
Sbjct: 386  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 445

Query: 1333 SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            + GGH ++  LL++ GA+++  ++   TPLM A R+GH ++V  L+ +
Sbjct: 446  ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493



 Score = 75.1 bits (183), Expect = 8e-13
 Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 5/205 (2%)

Query: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLE 549
           A+GA++     ETQ     L    G  +++    KA AD E+    ++ +  A  E    
Sbjct: 130 AEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189

Query: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
           L +       N H        +L  AC +G  +    LL  G  +   +E G + L  A 
Sbjct: 190 LTRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246

Query: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
            AG+    Q L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+
Sbjct: 247 SAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306

Query: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
           T L  A  GG  ++V  LL+   N+
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANI 331


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score = 1138 bits (2943), Expect = 0.0
 Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)

Query: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
           MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1   MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60

Query: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
           GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61  GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120

Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
           TSEIFLSSTAEGADLRTVDPETQARLEALLEAA           AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169

Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
           CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229

Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
           LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
           QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349

Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
           GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
           EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529

Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
           EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E 
Sbjct: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588

Query: 601 GRTPLMKAARAGHLCTVQF 619
            +T L     A H   V F
Sbjct: 589 MKTILEGIDPAKHQVRVAF 607



 Score =  248 bits (632), Expect = 7e-65
 Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)

Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
           L EA S G V   R LLD G  +N H+ E  ES L LAC  G+ ++ + LL   A+ E +
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
            ++   T LM A   G++++ +LLL   A VN  + +  + LT A  GG V++  +L+  
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           GAN+E+ N+ G+TPLMEAA  GH E+  +LL  GA IN  + E +E+ALTLAC  G  ++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376

Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
             FL++AGAD E       T LMEA  +GH+E+ + LL SGA V+    + ++ LT A  
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436

Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
            GH ++A +L++ GA+LE  ++ G TPLM+AAR GH   V  L+++GAN+N  T     T
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496

Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
            ++LAC GG   V + L+  GAD    ++ G ST L+EA++ GH  +V YLL    NV +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552

Query: 697 VPTT 700
              T
Sbjct: 553 TTAT 556



 Score =  204 bits (518), Expect = 1e-51
 Identities = 145/472 (30%), Positives = 232/472 (49%), Gaps = 53/472 (11%)

Query: 942  GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
            G++G++  E+ +V     +Q+ +  P +  T   +  L    +G  + T        L+ 
Sbjct: 91   GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148

Query: 999  LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057
            L+ A +   P      + +  C   E+ +  T   A  S            H     DT 
Sbjct: 149  LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196

Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
            +L  AC+ G    V  L+     +    ++G + L LA +AG+  + ++LL    ++E +
Sbjct: 197  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256

Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
              +   TPL  A SGG  ++V LLL   A+   ++ +  T L+ A +GG+V+I+K+LLN 
Sbjct: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316

Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
            GA I     ++ G +PLM AA  GHV   ++LLD G+ IN      + +ALTLAC++G  
Sbjct: 317  GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374

Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
            ++V  LL+  A+ EH+     T LMEA   G+ EV R+LLD GA VN P    S ++ LT
Sbjct: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432

Query: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
            +AA  GH +   LLI RGA+++  N +G TPL  A+  GH ++V LL+  GA+++A    
Sbjct: 433  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492

Query: 1358 K-------------------------------ITPLMSAFRKGHVKVVQYLV 1378
                                             TPLM A ++GH+++V+YL+
Sbjct: 493  TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544



 Score =  202 bits (513), Expect = 4e-51
 Identities = 142/417 (34%), Positives = 221/417 (52%), Gaps = 43/417 (10%)

Query: 996  LDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNH 1055
            LD+  AA++      S+++ Q       E+CS    N   + +        ++ HTE   
Sbjct: 172  LDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDE---GRSVNEHTEEG- 227

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKG-FTPLILAATAGHVGVVEILLDKGGDI 1114
            ++ L LAC+ G+ EL  VL+A  A +E R  KG  TPL+ A++ G++ +V++LL    D+
Sbjct: 228  ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 287

Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
             +QS  T +T L+ AC+GG  ++V +LL  GAN E  N + +TPL  AAS G+V + ++L
Sbjct: 288  NSQSA-TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346

Query: 1175 LNAGAEINSRTG----SKLGIS----------------------------PLMLAAMNGH 1202
            L+ GA IN+ +     S L ++                             LM A M+GH
Sbjct: 347  LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 406

Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
            V   +LLLD G+ +N   ++  +  LTLA   G  E+ +LL++R AN+E     G TPLM
Sbjct: 407  VEVARLLLDSGAQVNMPADSFESP-LTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465

Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
            EAA  G+ E+  +LL +GA++NA     +++TALT+A   G  +  + LI  GA I++  
Sbjct: 466  EAAREGHEEMVALLLAQGANINAQ-TEETQETALTLACCGGFSEVADFLIKAGADIELGC 524

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
               +TPL  AS  GH ++V+ L+ +GA+V A      T L  A   GH  V   L++
Sbjct: 525  ---STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578



 Score =  191 bits (486), Expect = 6e-48
 Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)

Query: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
            D D +++S   +TALT ACAGG  ++V VL+   A IE  ++ G TPL+ AA+AGHV V 
Sbjct: 284  DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343

Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
             +LLD G  I   S   K++ L+LAC  G  ++V  LL  GA++EH+    +T L  A  
Sbjct: 344  RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
             G+V + ++LL++GA++N    S    SPL LAA  GHV    LL++ G+++  ++    
Sbjct: 404  DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
             T L  A  +G  E+V+LLL + AN+  +  +T  T L  A  GG++EV   L+  GAD+
Sbjct: 461  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
                      T L  A+ +GH +  + L+  GA++      G+T L  A   GH DV  +
Sbjct: 521  EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575

Query: 1344 LVQAGADVDAADNRK 1358
            L+QAGAD+D  ++ K
Sbjct: 576  LLQAGADLDKQEDMK 590



 Score =  168 bits (425), Expect = 7e-41
 Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)

Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
           AL+EA      EV R L  S                  +C      AAL   +  N    
Sbjct: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190

Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
                  L EA  +G    V  LL +G ++N  TEE  E+ L LAC  G+ E+A  L+  
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249

Query: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
            A++E     G  TPLM AS  G+L++VK LL   A+V++ +ATG+TALTYAC  G  D+
Sbjct: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309

Query: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
             VLL  GA++E  +E G TPLM+AA AGH+   + L+  GA +N  +     + ++LAC
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369

Query: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
             GHL +V  LL  GAD  H+  +  T L+EA   GH  V   LLD
Sbjct: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415



 Score =  155 bits (391), Expect = 6e-37
 Identities = 102/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)

Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
            L+ ACS G    V  LL  G +         + L LA S GY  + ++LL   A +  R 
Sbjct: 198  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 256

Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
            G+K  I+PLM A+  G++  VKLLL   +D+N+Q  T  NTALT AC  G  ++V +LL+
Sbjct: 257  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 315

Query: 1246 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305
              AN+E   + G TPLMEAAS G+ EV RVLLD GA +N       +++ALT+A  KGH 
Sbjct: 316  EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 374

Query: 1306 ---------------------------------KFCELLIHRGAHIDVRNKKGNTPLWLA 1332
                                             +   LL+  GA +++      +PL LA
Sbjct: 375  DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434

Query: 1333 SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            + GGH ++  LL++ GA+++  ++   TPLM A R+GH ++V  L+ +
Sbjct: 435  ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 43/135 (31%), Positives = 63/135 (46%)

Query: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
           N H        +L  AC +G  +    LL  G  +   +E G + L  A  AG+    Q 
Sbjct: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245

Query: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
           L++  ANV       D T +  A +GG+L +V+LLL H AD   +   G+T L  A  GG
Sbjct: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305

Query: 680 HTNVVSYLLDYPNNV 694
             ++V  LL+   N+
Sbjct: 306 FVDIVKVLLNEGANI 320


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  257 bits (657), Expect = 9e-68
 Identities = 201/635 (31%), Positives = 289/635 (45%), Gaps = 79/635 (12%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
            L  A   G    V  L+  G ++N   ++G + L  A   G+ E+   LL     V D  
Sbjct: 582  LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV-DCA 640

Query: 269  NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
            +    T L AA+ GG+ DIV  LL H A+VN     G TAL  A   G  +IV+ LL+ G
Sbjct: 641  DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700

Query: 329  ANIEDHNENGHTPLMEAA-----SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
            A +   + +G T L  AA     S GH  V  +L+D GA ++ H ++   + L +A Y+G
Sbjct: 701  AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 759

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH-------------------------- 417
            H+D+V  LLE GAD +H  +   T L+ A   GH                          
Sbjct: 760  HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819

Query: 418  -------VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
                   VEV R LLD G   N   D+  +PL +AA  GH  +   LIE+GA   E++++
Sbjct: 820  IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879

Query: 471  GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
            G  P + A++EGH + V +LL   +NI+ +  + +  AL +A   G  ++ + L   GAD
Sbjct: 880  GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGAD 938

Query: 531  I---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
            +   +      L   + E  L + +Y L +GANV A+ A G TAL  +C  GH ++  VL
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 588  LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647
            +   AD+       R+ L  AA  GH+  VQ LI  GA V+  T N   T + +A   GH
Sbjct: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH-TCNQGATALCIAAQEGH 1057

Query: 648  LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP----NNVLSVPTTDVS 703
            + VV++LL HGADP H  + G T +  AAK GH+ ++  L  Y     N     P   + 
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTME 1117

Query: 704  QLPPPSQDQS------------------------QVPRVPTHTLAMVVPPQEPDRTSQEN 739
            Q P  S                             +P  PTH  A   P + PD T    
Sbjct: 1118 QKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTH--AFSSPSESPDSTVDRQ 1175

Query: 740  SPAL----LGVQKGTSKQKSSSLQVADQDLLPSFH 770
              +L    L   K +S + +SS   A    + SFH
Sbjct: 1176 KSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFH 1210



 Score =  234 bits (597), Expect = 8e-61
 Identities = 164/513 (31%), Positives = 252/513 (49%), Gaps = 45/513 (8%)

Query: 219  NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278
            +++R LLD G SVN+    G +LL  A  +G  ++  +L++  A++E     G  TPL  
Sbjct: 526  DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584

Query: 279  ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
            A+  G+  +V  L+   A++N     G TAL  A  GG  ++V  LL  G  ++  + + 
Sbjct: 585  AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644

Query: 339  HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
             T L  AA  GH ++   LL HGA +N   NE + +AL  A Y GH ++V  LL+ GA+ 
Sbjct: 645  RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703

Query: 399  EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
             H+  +  TAL  A +      GH  V  LL+D GA+V+       +PL +AA  GHV++
Sbjct: 704  NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763

Query: 454  AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
              LL+E GA+++  ++ G TPL+ AA  GH  +V  LL  GA +++   E + T L++A 
Sbjct: 764  VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822

Query: 514  CGGFSEVADFLIKAGAD---------------------------IELGCST--------- 537
              G  EV   L+  G D                           IE G  T         
Sbjct: 823  AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 538  PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
            P + ASQEGH + V+ LL + +N+      G  AL  A   GH D+ ++L   GAD+  +
Sbjct: 883  PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942

Query: 598  SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
               GR  L   A    L   ++ +  GANV  + A    T + ++C  GH+ +V++L+A+
Sbjct: 943  DADGRPTLYILALENQLTMAEYFLENGANVEASDAEG-RTALHVSCWQGHMEMVQVLIAY 1001

Query: 658  GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
             AD      +  + L  AA  GH  VV  L+++
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034



 Score =  215 bits (548), Expect = 4e-55
 Identities = 147/480 (30%), Positives = 235/480 (48%), Gaps = 42/480 (8%)

Query: 200  NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
            +    D+R+   A +  G  + V  LL  G  VN+   EG + L  A   G+ E+ + LL
Sbjct: 638  DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697

Query: 259  AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
               A V      G     +  L   +S G+  +V LL+   A+V+     G T L  A  
Sbjct: 698  DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757

Query: 315  GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
             G VD+V +LL  GA+++  + NG TPL+ AAS GH  V   LL  GA +++  +E + +
Sbjct: 758  EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816

Query: 375  ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 434
             L++A  +G++++VR LL+ G D+ H+ D   T L  A  +GH  +   L++ GA+ N  
Sbjct: 817  VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876

Query: 435  ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
             +    P  LA+  GH +   +L+E  +N+++   +G   L  AA EGH ++V LL + G
Sbjct: 877  DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936

Query: 495  ANINAQTEETQ--------------------------------ETALTLACCGGFSEVAD 522
            A++N +  + +                                 TAL ++C  G  E+  
Sbjct: 937  ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996

Query: 523  FLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
             LI   AD+    +   + L  A+ +GH+++V+ L+  GA V  T   G TAL  A + G
Sbjct: 997  VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056

Query: 580  HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGA-NVNRATANNDHTV 638
            H DV  VLL+ GAD  H  + GRT +  AA+ GH   ++ L   GA ++N  + +  HT+
Sbjct: 1057 HIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTM 1116



 Score =  209 bits (531), Expect = 4e-53
 Identities = 150/453 (33%), Positives = 226/453 (49%), Gaps = 18/453 (3%)

Query: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
           E+ Q+L+    H N ED     D T  +   +    D ++ LL + A VN   + G T L
Sbjct: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
             A   G +D+V +L++ GA++E  + +GHTPL  AA  GH +V   L+  GA IN H++
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608

Query: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
           +   +AL  A + GH ++V  LL AG   +    +  TAL  A   GH ++   LL  GA
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668

Query: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484
           +VN   +   + L  AA  GH E+   L++ GA +   + +G T L  A     A +GH 
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728

Query: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541
            +V+LL+ +GA ++   ++   T L +A   G  +V D L++ GAD+   +    TPL+ 
Sbjct: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787

Query: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
           A+  GH  +V  LL  GA V +  + G T L+ A   G+ +V   LL  G D  H  + G
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847

Query: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
            TPL  AA  GH    + LI +GA  N    N+      LA   GH   V++LL + ++ 
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEID-NDGRIPFILASQEGHYDCVQILLENKSNI 906

Query: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
             R  DG   L  AA  GH ++V  L  +  +V
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939



 Score =  188 bits (477), Expect = 7e-47
 Identities = 123/343 (35%), Positives = 192/343 (55%), Gaps = 16/343 (4%)

Query: 1047 IDAHTESNHD-----TALTLAC-----AGGHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
            +D   E NH+     TAL++A      + GH  +VS+LI R A+++H DK G TPL++AA
Sbjct: 697  LDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAA 756

Query: 1097 TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
              GHV VV++LL+ G D++  ++    TPL  A S G   VV+ LL  GA  +  +    
Sbjct: 757  YEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815

Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
            T LS+A++ G V +++ LL+ G + N R  +  G +PL +AA  GH    + L++ G+  
Sbjct: 816  TVLSIASAQGNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGART 873

Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
            N +I+ +      LA  +G  + V +LL+ K+N++ R   G   L  AA  G+ ++  +L
Sbjct: 874  N-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932

Query: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
               GADVN       R T L I A +      E  +  GA+++  + +G T L ++   G
Sbjct: 933  FSHGADVNCKDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990

Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            H ++VQ+L+   ADV+AADN K + L SA  +GHVKVVQ L++
Sbjct: 991  HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033



 Score =  174 bits (441), Expect = 1e-42
 Identities = 122/334 (36%), Positives = 181/334 (54%), Gaps = 11/334 (3%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +SN  T L  A   G  ++V++L++R A +E  D  G TPL LAA  GH  VV  L+  G
Sbjct: 542  DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
             +I   +++   T L  A  GG  EVV  LL  G   +  +    T L  AA GG+ +I+
Sbjct: 602  ANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
              LL  GAE+N       G + L+ AA  GH   V+ LLD G+++N + + +  TAL++A
Sbjct: 661  LNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALSVA 717

Query: 1232 CF-----QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
                   +G A VVSLL+DR A V+H  K G+TPL+ AA  G+ +V  +LL+ GADV+  
Sbjct: 718  ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-- 775

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
               ++  T L  AA  GH      L+  GA +D  + +G T L +AS  G+ +VV+ L+ 
Sbjct: 776  HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             G D +  D+   TPL  A  +GH  + + L+++
Sbjct: 836  RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869



 Score =  168 bits (426), Expect = 5e-41
 Identities = 117/336 (34%), Positives = 178/336 (52%), Gaps = 8/336 (2%)

Query: 1048 DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            D   E  H  T LTLA   GH ++V+ LI   A I H D+ G+T L  AA  GH  VV  
Sbjct: 570  DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL  G  ++  ++    T L  A  GG +++V  LL  GA     +    T L  AA  G
Sbjct: 630  LLYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMG 688

Query: 1167 YVNIIKILLNAGAEINSRT---GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
            +  I++ LL+ GAE+N       + L ++ L + A  GH   V LL+D G++++   + +
Sbjct: 689  HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKD 747

Query: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
              T L +A ++G  +VV LLL+  A+V+H    G TPL+ AAS G+A V   LL  GA V
Sbjct: 748  GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
            ++  + S   T L+IA+ +G+ +    L+ RG   + R+  G TPL +A+  GH  + + 
Sbjct: 808  DS--IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865

Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L++ GA  +  DN    P + A ++GH   VQ L++
Sbjct: 866  LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901



 Score =  163 bits (413), Expect = 2e-39
 Identities = 112/314 (35%), Positives = 158/314 (50%), Gaps = 9/314 (2%)

Query: 1068 EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLS 1127
            +E++ +L+   A +   D +  T  I+         +  LLD G  +  Q +    T L+
Sbjct: 494  QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550

Query: 1128 LACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1187
             A   G  +VV+LL++RGA+ E  +   +TPL+LAA  G+  ++  L+  GA IN     
Sbjct: 551  NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610

Query: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247
              G + L  AA  GH   V  LL  G  ++   + +  TAL  A + G  ++V  LL   
Sbjct: 611  --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667

Query: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1304
            A V      G T L+ AA  G+ E+   LLD GA+VN   V         AL + A KGH
Sbjct: 668  AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727

Query: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMS 1364
                 LLI RGA +D  +K G TPL +A+  GH DVV LL++ GADVD  DN   TPL++
Sbjct: 728  ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787

Query: 1365 AFRKGHVKVVQYLV 1378
            A   GH  VV  L+
Sbjct: 788  AASMGHASVVNTLL 801



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 8/181 (4%)

Query: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
            ++LL+  G+ +N+  E +R + +     + R + +  LLD  A+V      G T L  AA
Sbjct: 497  LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553

Query: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325
              G  +V  +L+ +GAD+          T LT+AA +GH K    LI  GA+I+  ++ G
Sbjct: 554  YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVN 1382
             T L  A+ GGH +VV  L+ AG  VD AD    T L +A   GH  +V  L++   EVN
Sbjct: 612  WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 1383 Q 1383
            +
Sbjct: 672  K 672


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  237 bits (605), Expect = 1e-61
 Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)

Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
           V   L+  A  L R K   S  H A Q D            V  V+ LL     V++ T 
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 342

Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
           +  + L +A   G+Y + ++LL   AN   R   G  TPL  A     + +++LL+ + A
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 401

Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
            + + + +G T +  A   G ++IV +LL  GA+ +  N  G T L  AA AG VEV R 
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
           LL +GA ++  + E +++ L +A   G  ++V+ LL+  A  +  T   +T L  +  +G
Sbjct: 462 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520

Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
            V+VA +LL++GA  ++      +PL +AA  G +++A LL++R A  +     G TPL 
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580

Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
            AA   ++++  LLL +GA+ +A T +   T L +A      ++A  L+  GA+  +   
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639

Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
              TPL  ASQEGH ++V  LL  GAN+H +T +G T+L  A +    +VAD+L + GAD
Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699

Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
            +  ++ G TPL+ A   G++  V FL+ +GANVN A   N +T +  A   GH  ++ +
Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 758

Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
           LL HGA P     +G+T L  A + G+ +VV  L      V +  TT         + + 
Sbjct: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 812

Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
            VP   T  L         D + +E    + G   G    +   L+    D LPS
Sbjct: 813 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 856



 Score =  214 bits (546), Expect = 7e-55
 Identities = 167/512 (32%), Positives = 252/512 (49%), Gaps = 25/512 (4%)

Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
           +T M  ++  NA      S   A   G+++ V + L  G  +N   + G + L LA   G
Sbjct: 1   MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54

Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
           +  L Q LL   ++V+    KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L
Sbjct: 55  HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
             A     +D+VK LL  GAN     E+G TPL  A   GH +   +LL+     N    
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168

Query: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
           + +  AL +A  K        LL  +  AD + K      T+   T L  A   G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            LLL+ GA V+  A +  +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR 
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
           GH+++V LLL +GA + A+T+    + L +A  G   E    L++  A   D+ L   T 
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  A+  GH  + K LL   AN +A    G T L  AC+     V ++L++ GA ++  +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           E G TP+  AA  GHL  V  L+  GA+ +  T     T + +A   G + VV  LL +G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNG 466

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
           A    R ++  T L  A++ G T +V  LL +
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498



 Score =  163 bits (412), Expect = 2e-39
 Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)

Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
            I  V   +  G+N S+ T +  TP + + Q   N A   +           P++ I A  
Sbjct: 122  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +     AL L      +    +++ R  +       GFTPL +AA  G+V V  +LL++G
Sbjct: 182  DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 235

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              ++  + R   TPL +A   G   +V LLL RG   + +     TPL  AA  G+  ++
Sbjct: 236  AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            ++LL  GA + +RT  K G+SPL +AA   HV  VK LL   + ++  +  +  TAL +A
Sbjct: 295  ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 351

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
               G   V  LLLD++AN   RA  G TPL  A      +V  +L+  GA + A  +  S
Sbjct: 352  AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 409

Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
              T + +AA  GH     LL+  GA  DV N +G T L +A+  G  +VV+ L++ GA V
Sbjct: 410  GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469

Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
            DA    + TPL  A R G  ++VQ L++ +
Sbjct: 470  DARAREEQTPLHIASRLGKTEIVQLLLQHM 499



 Score =  161 bits (407), Expect = 9e-39
 Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            I A TES   T + +A   GH  +V +L+   A  +  + +G T L +AA AG V VV  
Sbjct: 403  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL  G  ++A++ R + TPL +A   G+ E+V LLL   A+ +    + YTPL ++A  G
Sbjct: 462  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
             V++  +LL AGA  +  T  K G +PL +AA  G +   KLLL   +  ++  + N  T
Sbjct: 521  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 578  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LA+     +V  +L +
Sbjct: 637  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             GAD DA      TPL+ A   G+VK+V +L+K+
Sbjct: 696  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729



 Score =  152 bits (384), Expect = 4e-36
 Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +S+ + +   A   G+ + V   +     I   ++ G   L LAA  GHVG+V+ LL +G
Sbjct: 7    KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              +++ +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 67   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 126  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
              +   +  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 179  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  A+  GH  VV+L
Sbjct: 239  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296

Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 297  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348



 Score =  145 bits (365), Expect = 6e-34
 Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            +DA       T L +A   G  E+V +L+   A  +     G+TPL ++A  G V V  +
Sbjct: 469  VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527

Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
            LL+ G    A S  TK   TPL +A   G  +V  LLL R A  +    +  TPL +AA 
Sbjct: 528  LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
                 +  +LL  GA  ++   +K G +PL +AA    +     LL+ G++ N  +    
Sbjct: 585  YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 641

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
             T L LA  +G  ++V+LLLD+ AN+    K+GLT L  AA      V  +L   GAD +
Sbjct: 642  VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701

Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
            A        T L +A   G+ K    L+ +GA+++ + K G TPL  A+  GH  ++ +L
Sbjct: 702  AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759

Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
            +Q GA  +A      T L  A R G++ VV  L K V +     E      TIT+K  L 
Sbjct: 760  LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 813

Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
                  E +  + ++       +    L+  DL++  ++S
Sbjct: 814  VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 853



 Score =  120 bits (300), Expect = 2e-26
 Identities = 94/306 (30%), Positives = 146/306 (47%), Gaps = 42/306 (13%)

Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
           AA  G+++     ++ G ++   N  G   L  AA+EGH  +V  LL +G+++++ T++ 
Sbjct: 17  AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76

Query: 505 QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 561
             TAL +A   G +EV   L+K GA+I        TPL  A+QE H+++VKYLL +GAN 
Sbjct: 77  N-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 562 HATTATGDTALTYACENGHTDVADVLLQA------------------------------- 590
              T  G T L  A + GH     +LL+                                
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195

Query: 591 GADLEHE------SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
            AD++ +      +E G TPL  AA  G++     L+++GA V+  TA N  T + +A  
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASK 254

Query: 645 GGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQ 704
            G+  +V+LLL  G     + +DG T L  AA+ GH  VV  LL+    +L+     +S 
Sbjct: 255 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314

Query: 705 LPPPSQ 710
           L   +Q
Sbjct: 315 LHMAAQ 320


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  237 bits (605), Expect = 1e-61
 Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)

Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
           V   L+  A  L R K   S  H A Q D            V  V+ LL     V++ T 
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363

Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
           +  + L +A   G+Y + ++LL   AN   R   G  TPL  A     + +++LL+ + A
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422

Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
            + + + +G T +  A   G ++IV +LL  GA+ +  N  G T L  AA AG VEV R 
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
           LL +GA ++  + E +++ L +A   G  ++V+ LL+  A  +  T   +T L  +  +G
Sbjct: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
            V+VA +LL++GA  ++      +PL +AA  G +++A LL++R A  +     G TPL 
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
            AA   ++++  LLL +GA+ +A T +   T L +A      ++A  L+  GA+  +   
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
              TPL  ASQEGH ++V  LL  GAN+H +T +G T+L  A +    +VAD+L + GAD
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
            +  ++ G TPL+ A   G++  V FL+ +GANVN A   N +T +  A   GH  ++ +
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779

Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
           LL HGA P     +G+T L  A + G+ +VV  L      V +  TT         + + 
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833

Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
            VP   T  L         D + +E    + G   G    +   L+    D LPS
Sbjct: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877



 Score =  214 bits (544), Expect = 1e-54
 Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
             AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GHL  
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446

Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
           V  L+  GA+ +  T     T + +A   G + VV  LL +GA    R ++  T L  A+
Sbjct: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505

Query: 677 KGGHTNVVSYLLDY 690
           + G T +V  LL +
Sbjct: 506 RLGKTEIVQLLLQH 519



 Score =  202 bits (515), Expect = 3e-51
 Identities = 171/531 (32%), Positives = 254/531 (47%), Gaps = 46/531 (8%)

Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 319 DIVKVLLNEGAN------------------------IEDHN-------------ENGHTP 341
             V +LL                               DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
            G  +V   LL+ GA ++  +   +TPL  A+R G    VQ L+   A+ + AT N  +T
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YT 532

Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
            + ++   G + V  +LL  GA  +   K G T L  AAK G  +V   LL
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583



 Score =  163 bits (412), Expect = 2e-39
 Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)

Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
            I  V   +  G+N S+ T +  TP + + Q   N A   +           P++ I A  
Sbjct: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +     AL L      +    +++ R  +       GFTPL +AA  G+V V  +LL++G
Sbjct: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              ++  + R   TPL +A   G   +V LLL RG   + +     TPL  AA  G+  ++
Sbjct: 257  AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            ++LL  GA + +RT  K G+SPL +AA   HV  VK LL   + ++  +  +  TAL +A
Sbjct: 316  ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
               G   V  LLLD++AN   RA  G TPL  A      +V  +L+  GA + A  +  S
Sbjct: 373  AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430

Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
              T + +AA  GH     LL+  GA  DV N +G T L +A+  G  +VV+ L++ GA V
Sbjct: 431  GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
            DA    + TPL  A R G  ++VQ L++ +
Sbjct: 491  DARAREEQTPLHIASRLGKTEIVQLLLQHM 520



 Score =  161 bits (407), Expect = 9e-39
 Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)

Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L   
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328

Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
           ++ G +PL  AA+  H+  V+ L+   A V+  T +   T + +A   GH  V +LLL  
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
            A+P  R  +G T L  A K     V+  L+ Y  ++ ++  + ++ +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435



 Score =  161 bits (407), Expect = 9e-39
 Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            I A TES   T + +A   GH  +V +L+   A  +  + +G T L +AA AG V VV  
Sbjct: 424  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL  G  ++A++ R + TPL +A   G+ E+V LLL   A+ +    + YTPL ++A  G
Sbjct: 483  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
             V++  +LL AGA  +  T  K G +PL +AA  G +   KLLL   +  ++  + N  T
Sbjct: 542  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 599  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LA+     +V  +L +
Sbjct: 658  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             GAD DA      TPL+ A   G+VK+V +L+K+
Sbjct: 717  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750



 Score =  159 bits (401), Expect = 4e-38
 Identities = 141/462 (30%), Positives = 205/462 (44%), Gaps = 78/462 (16%)

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV--------- 351
           + +  N +   A   G +D V   L  G +I   N+NG   L  AA  GHV         
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 352 ------------------------EVARVLLDHGAGINTHS-NEFKESALTLACYKGHLD 386
                                   EV +VL+  GA IN  S N F  + L +A  + H+D
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--TPLYMAAQENHID 144

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPA--------- 435
           +V++LLE GA+Q   T++  T L  A   GH +   +LL  D+  +V +PA         
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 204

Query: 436 --------------------------DSFESPLTLAACGGHVELAALLIERGANLEEVND 469
                                     +S  +PL +AA  G+V +A LL+ RGA ++    
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264

Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
            G TPL  A++ G+  MV LLL +G  I+A+T +   T L  A   G  +V + L++ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERGA 323

Query: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
            +        +PL  A+Q  H+E VK+LL   A V   T    TAL  A   GH  V  +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGG 646
           LL   A+    +  G TPL  A +   +  ++ L+  GA++ +A   +  T + +A   G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMG 442

Query: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
           HL +V LLL +GA P      G T L  AA+ G   VV  LL
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484



 Score =  152 bits (384), Expect = 4e-36
 Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +S+ + +   A   G+ + V   +     I   ++ G   L LAA  GHVG+V+ LL +G
Sbjct: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              +++ +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
              +   +  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  A+  GH  VV+L
Sbjct: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369



 Score =  145 bits (365), Expect = 6e-34
 Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            +DA       T L +A   G  E+V +L+   A  +     G+TPL ++A  G V V  +
Sbjct: 490  VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548

Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
            LL+ G    A S  TK   TPL +A   G  +V  LLL R A  +    +  TPL +AA 
Sbjct: 549  LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
                 +  +LL  GA  ++   +K G +PL +AA    +     LL+ G++ N  +    
Sbjct: 606  YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
             T L LA  +G  ++V+LLLD+ AN+    K+GLT L  AA      V  +L   GAD +
Sbjct: 663  VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
            A        T L +A   G+ K    L+ +GA+++ + K G TPL  A+  GH  ++ +L
Sbjct: 723  AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
            +Q GA  +A      T L  A R G++ VV  L K V +     E      TIT+K  L 
Sbjct: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834

Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
                  E +  + ++       +    L+  DL++  ++S
Sbjct: 835  VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874



 Score =  119 bits (299), Expect = 3e-26
 Identities = 99/343 (28%), Positives = 155/343 (45%), Gaps = 47/343 (13%)

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ+ +   T L +A      +V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDV 145

Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN----------------- 560
             +L++ GA+         TPL  A Q+GH + V  LL +                    
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205

Query: 561 --------------------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
                               V+ TT +G T L  A   G+ +VA +LL  GA ++  +  
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
           G TPL  A++ G+   V+ L+ +G  ++ A   +  T +  A   GH  VVELLL  GA 
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAARSGHDQVVELLLERGAP 324

Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
              R K+G + L  AA+G H   V +LL +       P  DV+
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQH-----KAPVDDVT 362



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/94 (32%), Positives = 45/94 (47%)

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
            P  S  + +   AA  G+       +  G  I+  N+ G   L LA+  GH  +VQ L+ 
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  237 bits (605), Expect = 1e-61
 Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)

Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
           V   L+  A  L R K   S  H A Q D            V  V+ LL     V++ T 
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363

Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
           +  + L +A   G+Y + ++LL   AN   R   G  TPL  A     + +++LL+ + A
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422

Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
            + + + +G T +  A   G ++IV +LL  GA+ +  N  G T L  AA AG VEV R 
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
           LL +GA ++  + E +++ L +A   G  ++V+ LL+  A  +  T   +T L  +  +G
Sbjct: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
            V+VA +LL++GA  ++      +PL +AA  G +++A LL++R A  +     G TPL 
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601

Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
            AA   ++++  LLL +GA+ +A T +   T L +A      ++A  L+  GA+  +   
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660

Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
              TPL  ASQEGH ++V  LL  GAN+H +T +G T+L  A +    +VAD+L + GAD
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720

Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
            +  ++ G TPL+ A   G++  V FL+ +GANVN A   N +T +  A   GH  ++ +
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779

Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
           LL HGA P     +G+T L  A + G+ +VV  L      V +  TT         + + 
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833

Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
            VP   T  L         D + +E    + G   G    +   L+    D LPS
Sbjct: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877



 Score =  214 bits (544), Expect = 1e-54
 Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           S   A   G+++ V + L  G  +N   + G + L LA   G+  L Q LL   ++V+  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG+ T L  AS  G  ++VK+L+   A++N+QS  G T L  A     +D+VK LL  
Sbjct: 94  TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
           GAN     E+G TPL  A   GH +   +LL+     N    + +  AL +A  K     
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207

Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              LL  +  AD + K      T+   T L  A   G+V VA LLL+ GA V+  A +  
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           +PL +A+  G+  +  LL++RG  ++    +G TPL  AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
           +T+    + L +A  G   E    L++  A   D+ L   T L  A+  GH  + K LL 
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386

Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
             AN +A    G T L  AC+     V ++L++ GA ++  +E G TP+  AA  GHL  
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446

Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
           V  L+  GA+ +  T     T + +A   G + VV  LL +GA    R ++  T L  A+
Sbjct: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505

Query: 677 KGGHTNVVSYLLDY 690
           + G T +V  LL +
Sbjct: 506 RLGKTEIVQLLLQH 519



 Score =  202 bits (515), Expect = 3e-51
 Identities = 171/531 (32%), Positives = 254/531 (47%), Gaps = 46/531 (8%)

Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
           +   Q    +L  A  +G V  V++LL  G SV+  T++G + L +A  AG  E+ +VL+
Sbjct: 58  NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117

Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
              AN+  +   G  TPL  A+   ++D+VK LL + A+ ++ +  G T L  A   G  
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176

Query: 319 DIVKVLLNEGAN------------------------IEDHN-------------ENGHTP 341
             V +LL                               DHN             E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236

Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
           L  AA  G+V VA +LL+ GA ++ T  N    + L +A  +G+ +MV+ LL+ G   + 
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           KT +  T L  A   GH +V  LLL+ GA +     +  SPL +AA G HVE    L++ 
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            A +++V  +  T L  AA  GH  +  LLL + AN NA+      T L +AC     +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413

Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
            + L+K GA I+       TP+  A+  GHL +V  LL +GA+   T   G+TAL  A  
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
            G  +V   LL+ GA ++  +   +TPL  A+R G    VQ L+   A+ + AT N  +T
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YT 532

Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
            + ++   G + V  +LL  GA  +   K G T L  AAK G  +V   LL
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583



 Score =  163 bits (412), Expect = 2e-39
 Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)

Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
            I  V   +  G+N S+ T +  TP + + Q   N A   +           P++ I A  
Sbjct: 143  IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +     AL L      +    +++ R  +       GFTPL +AA  G+V V  +LL++G
Sbjct: 203  DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              ++  + R   TPL +A   G   +V LLL RG   + +     TPL  AA  G+  ++
Sbjct: 257  AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            ++LL  GA + +RT  K G+SPL +AA   HV  VK LL   + ++  +  +  TAL +A
Sbjct: 316  ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
               G   V  LLLD++AN   RA  G TPL  A      +V  +L+  GA + A  +  S
Sbjct: 373  AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430

Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
              T + +AA  GH     LL+  GA  DV N +G T L +A+  G  +VV+ L++ GA V
Sbjct: 431  GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490

Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
            DA    + TPL  A R G  ++VQ L++ +
Sbjct: 491  DARAREEQTPLHIASRLGKTEIVQLLLQHM 520



 Score =  161 bits (407), Expect = 9e-39
 Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)

Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
           + +   + AA AG+++     L  G  INT  N+   +AL LA  +GH+ +V+ LL  G+
Sbjct: 30  DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
             +  T + +TAL  A + G  EV ++L+  GA +N  + +  +PL +AA   H+++   
Sbjct: 89  SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
           L+E GAN     ++G+TPL  A ++GH + VA+LL             +I A+ ++T+  
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208

Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
           AL L                           A   G   VA  L+  GA ++       T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
           PL  AS+ G+  +VK LL  G  + A T  G T L  A  +GH  V ++LL+ GA L   
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328

Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
           ++ G +PL  AA+  H+  V+ L+   A V+  T +   T + +A   GH  V +LLL  
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
            A+P  R  +G T L  A K     V+  L+ Y  ++ ++  + ++ +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435



 Score =  161 bits (407), Expect = 9e-39
 Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            I A TES   T + +A   GH  +V +L+   A  +  + +G T L +AA AG V VV  
Sbjct: 424  IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL  G  ++A++ R + TPL +A   G+ E+V LLL   A+ +    + YTPL ++A  G
Sbjct: 483  LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
             V++  +LL AGA  +  T  K G +PL +AA  G +   KLLL   +  ++  + N  T
Sbjct: 542  QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      +V  LLL++ A+    AK G TPL  AA     ++   LL+ GA+ N  
Sbjct: 599  PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +A+ +GH     LL+ +GA+I +  K G T L LA+     +V  +L +
Sbjct: 658  -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             GAD DA      TPL+ A   G+VK+V +L+K+
Sbjct: 717  HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750



 Score =  159 bits (401), Expect = 4e-38
 Identities = 141/462 (30%), Positives = 205/462 (44%), Gaps = 78/462 (16%)

Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV--------- 351
           + +  N +   A   G +D V   L  G +I   N+NG   L  AA  GHV         
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 352 ------------------------EVARVLLDHGAGINTHS-NEFKESALTLACYKGHLD 386
                                   EV +VL+  GA IN  S N F  + L +A  + H+D
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--TPLYMAAQENHID 144

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPA--------- 435
           +V++LLE GA+Q   T++  T L  A   GH +   +LL  D+  +V +PA         
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 204

Query: 436 --------------------------DSFESPLTLAACGGHVELAALLIERGANLEEVND 469
                                     +S  +PL +AA  G+V +A LL+ RGA ++    
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264

Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
            G TPL  A++ G+  MV LLL +G  I+A+T +   T L  A   G  +V + L++ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERGA 323

Query: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
            +        +PL  A+Q  H+E VK+LL   A V   T    TAL  A   GH  V  +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGG 646
           LL   A+    +  G TPL  A +   +  ++ L+  GA++ +A   +  T + +A   G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMG 442

Query: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
           HL +V LLL +GA P      G T L  AA+ G   VV  LL
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484



 Score =  152 bits (384), Expect = 4e-36
 Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            +S+ + +   A   G+ + V   +     I   ++ G   L LAA  GHVG+V+ LL +G
Sbjct: 28   KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              +++ +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +++++
Sbjct: 88   SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            K LL  GA  N  T ++ G +PL +A   GH  AV +LL+  +D   ++   R  AL +A
Sbjct: 147  KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
              +   +  +LLL    N + ++K        +G TPL  AA  G   V  +LL++GA V
Sbjct: 200  ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259

Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
            +      +  T L +A+ +G+    +LL+ RG  ID + + G TPL  A+  GH  VV+L
Sbjct: 260  DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317

Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
            L++ GA + A     ++PL  A +  HV+ V++L++  ++ P D   + Y+  +
Sbjct: 318  LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369



 Score =  145 bits (365), Expect = 6e-34
 Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            +DA       T L +A   G  E+V +L+   A  +     G+TPL ++A  G V V  +
Sbjct: 490  VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548

Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
            LL+ G    A S  TK   TPL +A   G  +V  LLL R A  +    +  TPL +AA 
Sbjct: 549  LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
                 +  +LL  GA  ++   +K G +PL +AA    +     LL+ G++ N  +    
Sbjct: 606  YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
             T L LA  +G  ++V+LLLD+ AN+    K+GLT L  AA      V  +L   GAD +
Sbjct: 663  VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722

Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
            A        T L +A   G+ K    L+ +GA+++ + K G TPL  A+  GH  ++ +L
Sbjct: 723  AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780

Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
            +Q GA  +A      T L  A R G++ VV  L K V +     E      TIT+K  L 
Sbjct: 781  LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834

Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
                  E +  + ++       +    L+  DL++  ++S
Sbjct: 835  VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874



 Score =  119 bits (299), Expect = 3e-26
 Identities = 99/343 (28%), Positives = 155/343 (45%), Gaps = 47/343 (13%)

Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
           K  + + + + A   G+++     L  G  +N    +  + L LAA  GHV L   L+ R
Sbjct: 27  KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86

Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
           G++++    +G T L  A+  G  E+V +L+ +GANINAQ+ +   T L +A      +V
Sbjct: 87  GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDV 145

Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN----------------- 560
             +L++ GA+         TPL  A Q+GH + V  LL +                    
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205

Query: 561 --------------------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
                               V+ TT +G T L  A   G+ +VA +LL  GA ++  +  
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265

Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
           G TPL  A++ G+   V+ L+ +G  ++ A   +  T +  A   GH  VVELLL  GA 
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAARSGHDQVVELLLERGAP 324

Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
              R K+G + L  AA+G H   V +LL +       P  DV+
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQH-----KAPVDDVT 362



 Score = 44.3 bits (103), Expect = 0.002
 Identities = 31/94 (32%), Positives = 45/94 (47%)

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
            P  S  + +   AA  G+       +  G  I+  N+ G   L LA+  GH  +VQ L+ 
Sbjct: 26   PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
             G+ VD+A  +  T L  A   G  +VV+ LVKE
Sbjct: 86   RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  226 bits (576), Expect = 2e-58
 Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF-TPLHVA 576

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 630 --------------------------------ATANNDHTVVSLACAGGHLAVVELLLAH 657
                                           AT    +T + +A   G++ +V+ LL H
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
            AD   + K G + L +AA+ GHT++V+ LL     PN V S  TT ++
Sbjct: 757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805



 Score =  222 bits (565), Expect = 4e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 85  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 559

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596



 Score =  213 bits (542), Expect = 2e-54
 Identities = 177/559 (31%), Positives = 261/559 (46%), Gaps = 35/559 (6%)

Query: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
           DE    L    A N +   Q     L  A  +  +  V+ LL+ G + N  TE+G + L 
Sbjct: 124 DEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182

Query: 244 LACSAGYYELAQVLL-----------AMHANVE-----------------DRGNKGDITP 275
           +A   G+  +   L+           A+H                     D  +K   TP
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+    L++ +LLL   A VN     G T L  A   G V +V++LL+ GA IE   
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++  TPL  AA  GHV ++ +LLDHGA I   +     S + +A    HLD VR LL+  
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYD 361

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
           A+ +  T +  T L  A   GH  VA++LLD GA+ N  A +  +PL +A    HV +  
Sbjct: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
           LL++ GA+++ V + G TPL  A+  GH  +V  LL +GA+ N    +  ET L +A   
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480

Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
           G +EVA +L++  A +        TPL  A++ GH  +VK LL + AN +  T  G T L
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540

Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
             A   GH +    LL+  A     ++ G TPL  AA+ G +   + L+ + A+ N A  
Sbjct: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599

Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
            N  T + +A    +L +V+LLL  G  P     +G T L  AAK     V   LL Y  
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659

Query: 693 NVLSVPTTDVSQLPPPSQD 711
           +  +     V+ L   +Q+
Sbjct: 660 SANAESVQGVTPLHLAAQE 678



 Score =  210 bits (535), Expect = 1e-53
 Identities = 162/526 (30%), Positives = 251/526 (47%), Gaps = 44/526 (8%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714

Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
            VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN A     ++ +  
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 773

Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
           A   GH  +V LLL +GA P     DG+T L  A + G+ +V   L
Sbjct: 774 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score =  198 bits (504), Expect = 5e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 75  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432

Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 491

Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524



 Score =  166 bits (420), Expect = 3e-40
 Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T    +TAL +A   G +E+V  L+   A +  + +KGFTPL +AA   H+ VV+ LL+ 
Sbjct: 107  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
            G +   Q+  T+D  TPL++A   G + VV                              
Sbjct: 167  GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223

Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
            +LL    N +  + + +TPL +AA    +N+ ++LLN GA +N    +  GI+PL +A+ 
Sbjct: 224  VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 281

Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
             G+V  V+LLLD G    AQIET     LT    A   G   +  +LLD  A ++ + K 
Sbjct: 282  RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
            GL+P+  AA G + +  R+LL   A+++   +     T L +AA  GH++  ++L+ +GA
Sbjct: 338  GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395

Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
              + R   G TPL +A    H  V++LL++ GA +DA     +TPL  A   GH+ +V+ 
Sbjct: 396  KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455

Query: 1377 LVK 1379
            L++
Sbjct: 456  LLQ 458



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225

Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285

Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441



 Score =  160 bits (404), Expect = 2e-38
 Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H E+V  L+   A      + GFTPL +A   GH  VV  L++ G     
Sbjct: 146  TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205

Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
                  I A+++ T+                    TPL +A       V  LLL RGA+ 
Sbjct: 206  RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
                 +  TPL +A+  G V ++++LL+ GA+I ++T  +L  +PL  AA NGHV   ++
Sbjct: 266  NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 323

Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
            LLD G+ I A+ + N  + + +A      + V LLL   A ++      LTPL  AA  G
Sbjct: 324  LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382

Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
            +  V +VLLDKGA  N+  +     T L IA  K H +  ELL+  GA ID   + G TP
Sbjct: 383  HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440

Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L +AS  GH  +V+ L+Q GA  + ++ +  TPL  A R GH +V +YL++
Sbjct: 441  LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491



 Score =  157 bits (396), Expect = 2e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 430  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 489  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 548  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 605  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 665  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 723  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755



 Score =  155 bits (393), Expect = 4e-37
 Identities = 141/495 (28%), Positives = 231/495 (46%), Gaps = 45/495 (9%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 471  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 531  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 590  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 646

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 647  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 704

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 705  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764

Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD-------------IECMRYIATITD 1399
                +PL  A ++GH  +V  L+K     N+  SD             I     +  +TD
Sbjct: 765  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824

Query: 1400 KE---LLKKCHQC--VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKRE 1454
            +    L+   H+    ET+ +  D    E   + +I+ +EL   K          A +R+
Sbjct: 825  ETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFK----------AERRD 874

Query: 1455 KRKEKRKKKKEEQKRKQEEDEENK--PKENSELPE-----DEDEEENDEDVEQEVPIEPP 1507
             R    +K+  +   K ++  E+   P+    +PE      E++E+  ++ +++  I P 
Sbjct: 875  SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PS 933

Query: 1508 SATTTTTIGISATSA 1522
            S  T T+  IS  ++
Sbjct: 934  SPATETSDNISPVAS 948



 Score =  123 bits (308), Expect = 3e-27
 Identities = 97/326 (29%), Positives = 155/326 (47%), Gaps = 35/326 (10%)

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
           D++ K D   T+ + A   G+++ A   L +G  +N    +  + L LA+  GHV++   
Sbjct: 38  DRKKKADAA-TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
           L+ +   LE    +G T L  AA  G +E+V  L+  GAN+NAQ+++   T L +A    
Sbjct: 97  LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQEN 155

Query: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA-------------- 559
             EV  FL++ GA+  +      TPL  A Q+GH  +V +L+  G               
Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 215

Query: 560 ---------------NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 604
                          N    + TG T L  A    + +VA +LL  GA +    + G TP
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITP 275

Query: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHR 664
           L  A+R G++  V+ L+ +GA +   T  ++ T +  A   GH+ + E+LL HGA    +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAK 334

Query: 665 LKDGSTMLIEAAKGGHTNVVSYLLDY 690
            K+G + +  AA+G H + V  LL Y
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLLLQY 360



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
            + GL  L  A+  G+ ++   LL K  ++         +TAL IAA  G  +    L++ 
Sbjct: 76   QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 133

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
            GA+++ +++KG TPL++A+   H +VV+ L++ GA+ + A     TPL  A ++GH  VV
Sbjct: 134  GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 193

Query: 1375 QYLV 1378
             +L+
Sbjct: 194  AHLI 197



 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 2/121 (1%)

Query: 1259 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHI 1318
            T  + AA  G  +     L  G D+N      +    L +A+ +GH K    L+H+   +
Sbjct: 47   TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104

Query: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
            +   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++ H++VV++L+
Sbjct: 105  ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164

Query: 1379 K 1379
            +
Sbjct: 165  E 165


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  226 bits (576), Expect = 2e-58
 Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
                                           AT    +T + +A   G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
            AD   + K G + L +AA+ GHT++V+ LL     PN V S  TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772



 Score =  222 bits (565), Expect = 4e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score =  211 bits (537), Expect = 7e-54
 Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
            VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN A     ++ +  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740

Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
           A   GH  +V LLL +GA P     DG+T L  A + G+          T+  S++L   
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
            + +S P T V ++   S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822



 Score =  198 bits (504), Expect = 5e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458

Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491



 Score =  166 bits (420), Expect = 3e-40
 Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T    +TAL +A   G +E+V  L+   A +  + +KGFTPL +AA   H+ VV+ LL+ 
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
            G +   Q+  T+D  TPL++A   G + VV                              
Sbjct: 134  GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
            +LL    N +  + + +TPL +AA    +N+ ++LLN GA +N    +  GI+PL +A+ 
Sbjct: 191  VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248

Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
             G+V  V+LLLD G    AQIET     LT    A   G   +  +LLD  A ++ + K 
Sbjct: 249  RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
            GL+P+  AA G + +  R+LL   A+++   +     T L +AA  GH++  ++L+ +GA
Sbjct: 305  GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
              + R   G TPL +A    H  V++LL++ GA +DA     +TPL  A   GH+ +V+ 
Sbjct: 363  KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 1377 LVK 1379
            L++
Sbjct: 423  LLQ 425



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  160 bits (404), Expect = 2e-38
 Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H E+V  L+   A      + GFTPL +A   GH  VV  L++ G     
Sbjct: 113  TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172

Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
                  I A+++ T+                    TPL +A       V  LLL RGA+ 
Sbjct: 173  RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
                 +  TPL +A+  G V ++++LL+ GA+I ++T  +L  +PL  AA NGHV   ++
Sbjct: 233  NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290

Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
            LLD G+ I A+ + N  + + +A      + V LLL   A ++      LTPL  AA  G
Sbjct: 291  LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
            +  V +VLLDKGA  N+  +     T L IA  K H +  ELL+  GA ID   + G TP
Sbjct: 350  HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L +AS  GH  +V+ L+Q GA  + ++ +  TPL  A R GH +V +YL++
Sbjct: 408  LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458



 Score =  157 bits (398), Expect = 1e-37
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787

Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902

Query: 1518 SATSA 1522
            S  ++
Sbjct: 903  SPVAS 907



 Score =  157 bits (396), Expect = 2e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1369 GHVKVVQYLVK 1379
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
            + GL  L  A+  G+ ++   LL K  ++         +TAL IAA  G  +    L++ 
Sbjct: 43   QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
            GA+++ +++KG TPL++A+   H +VV+ L++ GA+ + A     TPL  A ++GH  VV
Sbjct: 101  GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 1375 QYLV 1378
             +L+
Sbjct: 161  AHLI 164


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  226 bits (576), Expect = 2e-58
 Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
                                           AT    +T + +A   G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
            AD   + K G + L +AA+ GHT++V+ LL     PN V S  TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772



 Score =  222 bits (565), Expect = 4e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score =  211 bits (537), Expect = 7e-54
 Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
            VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN A     ++ +  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740

Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
           A   GH  +V LLL +GA P     DG+T L  A + G+          T+  S++L   
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
            + +S P T V ++   S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822



 Score =  198 bits (504), Expect = 5e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458

Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491



 Score =  166 bits (420), Expect = 3e-40
 Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T    +TAL +A   G +E+V  L+   A +  + +KGFTPL +AA   H+ VV+ LL+ 
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
            G +   Q+  T+D  TPL++A   G + VV                              
Sbjct: 134  GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
            +LL    N +  + + +TPL +AA    +N+ ++LLN GA +N    +  GI+PL +A+ 
Sbjct: 191  VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248

Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
             G+V  V+LLLD G    AQIET     LT    A   G   +  +LLD  A ++ + K 
Sbjct: 249  RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
            GL+P+  AA G + +  R+LL   A+++   +     T L +AA  GH++  ++L+ +GA
Sbjct: 305  GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
              + R   G TPL +A    H  V++LL++ GA +DA     +TPL  A   GH+ +V+ 
Sbjct: 363  KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 1377 LVK 1379
            L++
Sbjct: 423  LLQ 425



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  160 bits (404), Expect = 2e-38
 Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H E+V  L+   A      + GFTPL +A   GH  VV  L++ G     
Sbjct: 113  TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172

Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
                  I A+++ T+                    TPL +A       V  LLL RGA+ 
Sbjct: 173  RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
                 +  TPL +A+  G V ++++LL+ GA+I ++T  +L  +PL  AA NGHV   ++
Sbjct: 233  NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290

Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
            LLD G+ I A+ + N  + + +A      + V LLL   A ++      LTPL  AA  G
Sbjct: 291  LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
            +  V +VLLDKGA  N+  +     T L IA  K H +  ELL+  GA ID   + G TP
Sbjct: 350  HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L +AS  GH  +V+ L+Q GA  + ++ +  TPL  A R GH +V +YL++
Sbjct: 408  LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458



 Score =  157 bits (398), Expect = 1e-37
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787

Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902

Query: 1518 SATSA 1522
            S  ++
Sbjct: 903  SPVAS 907



 Score =  157 bits (396), Expect = 2e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1369 GHVKVVQYLVK 1379
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
            + GL  L  A+  G+ ++   LL K  ++         +TAL IAA  G  +    L++ 
Sbjct: 43   QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
            GA+++ +++KG TPL++A+   H +VV+ L++ GA+ + A     TPL  A ++GH  VV
Sbjct: 101  GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 1375 QYLV 1378
             +L+
Sbjct: 161  AHLI 164


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  226 bits (576), Expect = 2e-58
 Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
                                           AT    +T + +A   G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
            AD   + K G + L +AA+ GHT++V+ LL     PN V S  TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772



 Score =  222 bits (565), Expect = 4e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score =  211 bits (537), Expect = 7e-54
 Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
            VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN A     ++ +  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740

Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
           A   GH  +V LLL +GA P     DG+T L  A + G+          T+  S++L   
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
            + +S P T V ++   S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822



 Score =  198 bits (504), Expect = 5e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458

Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491



 Score =  166 bits (420), Expect = 3e-40
 Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T    +TAL +A   G +E+V  L+   A +  + +KGFTPL +AA   H+ VV+ LL+ 
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
            G +   Q+  T+D  TPL++A   G + VV                              
Sbjct: 134  GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
            +LL    N +  + + +TPL +AA    +N+ ++LLN GA +N    +  GI+PL +A+ 
Sbjct: 191  VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248

Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
             G+V  V+LLLD G    AQIET     LT    A   G   +  +LLD  A ++ + K 
Sbjct: 249  RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
            GL+P+  AA G + +  R+LL   A+++   +     T L +AA  GH++  ++L+ +GA
Sbjct: 305  GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
              + R   G TPL +A    H  V++LL++ GA +DA     +TPL  A   GH+ +V+ 
Sbjct: 363  KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 1377 LVK 1379
            L++
Sbjct: 423  LLQ 425



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  160 bits (404), Expect = 2e-38
 Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H E+V  L+   A      + GFTPL +A   GH  VV  L++ G     
Sbjct: 113  TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172

Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
                  I A+++ T+                    TPL +A       V  LLL RGA+ 
Sbjct: 173  RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
                 +  TPL +A+  G V ++++LL+ GA+I ++T  +L  +PL  AA NGHV   ++
Sbjct: 233  NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290

Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
            LLD G+ I A+ + N  + + +A      + V LLL   A ++      LTPL  AA  G
Sbjct: 291  LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
            +  V +VLLDKGA  N+  +     T L IA  K H +  ELL+  GA ID   + G TP
Sbjct: 350  HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L +AS  GH  +V+ L+Q GA  + ++ +  TPL  A R GH +V +YL++
Sbjct: 408  LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458



 Score =  157 bits (398), Expect = 1e-37
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787

Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902

Query: 1518 SATSA 1522
            S  ++
Sbjct: 903  SPVAS 907



 Score =  157 bits (396), Expect = 2e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1369 GHVKVVQYLVK 1379
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
            + GL  L  A+  G+ ++   LL K  ++         +TAL IAA  G  +    L++ 
Sbjct: 43   QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
            GA+++ +++KG TPL++A+   H +VV+ L++ GA+ + A     TPL  A ++GH  VV
Sbjct: 101  GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 1375 QYLV 1378
             +L+
Sbjct: 161  AHLI 164


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  226 bits (576), Expect = 2e-58
 Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G+V  VR LLD G  +   T++  + L  A   G+  ++++LL   A ++ +   G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           +  A+ G +LD V+LLL +DA+++  +    T L  A   G   + KVLL++GA      
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
            NG TPL  A    HV V  +LL  GA I+  +    ES LT   +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
           + GA       ++ T L  A   GH EVA+ LL + A+VN  A   ++PL  AA  GH  
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
           +  LL+E  AN       G+TPL  AAREGH E V  LL + A+    T++   T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543

Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
              G   VA+ L++  A          TPL  A    +L++VK LL  G + H+    G 
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
           T L  A +    +VA  LLQ G     ES  G TPL  AA+ GH   V  L+SK AN N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
                                           AT    +T + +A   G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
            AD   + K G + L +AA+ GHT++V+ LL     PN V S  TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772



 Score =  222 bits (565), Expect = 4e-57
 Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +G V  V +LL +   +   T++G + L +A  AG  E+ + L+   ANV  +  KG
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
             TPL  A+   +L++VK LL + A+ N  +  G T L  A   G  ++V  L+N G   
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170

Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
                                      N +  ++ G TPL  AA   ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230

Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
            +N T  N    + L +A  +G++ MVR LL+ GA  E KT +  T L  A  +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288

Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
            +LLD GA +     +  SP+ +AA G H++   LL++  A ++++  +  TPL  AA  
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348

Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
           GH  +  +LL +GA  N++      T L +AC      V + L+K GA I+       TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
           L  AS  GHL +VK LL  GA+ + +    +T L  A   GHT+VA  LLQ  A +  ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467

Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
           +  +TPL  AAR GH   V+ L+   AN N AT    HT + +A   GH+  V  LL   
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
           A      K G T L  AAK G   V   LL+   +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563



 Score =  211 bits (537), Expect = 7e-54
 Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)

Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           Q++T++  E      A  +G V     LLD G  +   T+ G S + +A    + +  ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
           LL   A ++D      +TPL  A+  G+  + K+LL   A  NS++  G T L  AC   
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382

Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
            V ++++LL  GA+I+   E+G TPL  A+  GH+ + + LL  GA  N  SN   E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441

Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
            +A   GH ++ ++LL+  A    K  +  T L  A   GH  + +LLL++ A  N+   
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501

Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
           +  +PL +AA  GHVE    L+E+ A+   +  +G+TPL  AA+ G   +  LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
            NA  +                                    T L +A      EVA  L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
           ++ G           TPL  A+QEGH E+V  LL+  AN +    +G T L    + GH 
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681

Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
            VADVL++ G  ++  +  G TPL  A+  G++  V+FL+   A+VN A     ++ +  
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740

Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
           A   GH  +V LLL +GA P     DG+T L  A + G+          T+  S++L   
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800

Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
            + +S P T V ++   S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822



 Score =  198 bits (504), Expect = 5e-50
 Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           N+  +  L  AS  G++ +V  LL  +  + + +  GNTAL  A   G  ++V+ L+N G
Sbjct: 42  NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           AN+   ++ G TPL  AA   H+EV + LL++GA  N  + E   + L +A  +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160

Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
             L+  G   + +   +H                             T L  A    ++ 
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220

Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
           VA+LLL+ GA VN    +  +PL +A+  G+V +  LL++RGA +E    +  TPL  AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280

Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
           R GH  +  +LL  GA I A+T+    + + +A  G   +    L++  A   DI L   
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339

Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
           TPL  A+  GH  + K LL  GA  ++    G T L  AC+  H  V ++LL+ GA ++ 
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399

Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
            +E G TPL  A+  GHL  V+ L+ +GA+ N +    + T + +A   GH  V + LL 
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458

Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
           + A    + KD  T L  AA+ GHTN+V  LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491



 Score =  166 bits (420), Expect = 3e-40
 Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T    +TAL +A   G +E+V  L+   A +  + +KGFTPL +AA   H+ VV+ LL+ 
Sbjct: 74   TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
            G +   Q+  T+D  TPL++A   G + VV                              
Sbjct: 134  GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190

Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
            +LL    N +  + + +TPL +AA    +N+ ++LLN GA +N    +  GI+PL +A+ 
Sbjct: 191  VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248

Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
             G+V  V+LLLD G    AQIET     LT    A   G   +  +LLD  A ++ + K 
Sbjct: 249  RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
            GL+P+  AA G + +  R+LL   A+++   +     T L +AA  GH++  ++L+ +GA
Sbjct: 305  GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362

Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
              + R   G TPL +A    H  V++LL++ GA +DA     +TPL  A   GH+ +V+ 
Sbjct: 363  KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422

Query: 1377 LVK 1379
            L++
Sbjct: 423  LLQ 425



 Score =  160 bits (405), Expect = 1e-38
 Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)

Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           T  + AA +G+++ A   L +G  INT  N+   + L LA  +GH+ MV  LL      E
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
             T + +TAL  A + G  EV R L++ GA VN  +    +PL +AA   H+E+   L+E
Sbjct: 73  TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
            GAN     ++G+TPL  A ++GHE +VA L+  G          +I A+ ++T+  A+ 
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192

Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
           L            GF+            VA  L+  GA +        TPL  AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252

Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
            +V+ LL  GA +   T    T L  A  NGH  ++++LL  GA ++ +++ G +P+  A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
           A+  HL  V+ L+   A ++  T   DH T + +A   GH  V ++LL  GA P  R  +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
           G T L  A K  H  V+  LL    ++ +V  + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408



 Score =  160 bits (404), Expect = 2e-38
 Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H E+V  L+   A      + GFTPL +A   GH  VV  L++ G     
Sbjct: 113  TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172

Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
                  I A+++ T+                    TPL +A       V  LLL RGA+ 
Sbjct: 173  RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
                 +  TPL +A+  G V ++++LL+ GA+I ++T  +L  +PL  AA NGHV   ++
Sbjct: 233  NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290

Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
            LLD G+ I A+ + N  + + +A      + V LLL   A ++      LTPL  AA  G
Sbjct: 291  LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349

Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
            +  V +VLLDKGA  N+  +     T L IA  K H +  ELL+  GA ID   + G TP
Sbjct: 350  HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407

Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L +AS  GH  +V+ L+Q GA  + ++ +  TPL  A R GH +V +YL++
Sbjct: 408  LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458



 Score =  157 bits (398), Expect = 1e-37
 Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +T L +A   GH E+   L+   AK+  + K   TPL  AA  GH  +V++LL+   +  
Sbjct: 438  ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              +     TPL +A   G  E V  LL + A++       +TPL +AA  G V + ++LL
Sbjct: 498  LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
               A  N+    K G++PL +A  + ++  VKLLL  G   ++    N  T L +A  Q 
Sbjct: 557  ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
            + EV   LL    +    +  G+TPL  AA  G+AE+  +LL K A+ N      S  T 
Sbjct: 614  QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
            L + A +GH    ++LI  G  +D   + G TPL +AS+ G+  +V+ L+Q  ADV+A  
Sbjct: 672  LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731

Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
                +PL  A ++GH  +V  L+K     N+  SD    +   + +  I+  ++LK    
Sbjct: 732  KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787

Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
                +V  +      ++K+     + +D      E   + L + + +R++ R   +E++ 
Sbjct: 788  ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843

Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
                 K  Q  +    P+    +PE      E++E+  ++ +++  I P S  T T+  I
Sbjct: 844  LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902

Query: 1518 SATSA 1522
            S  ++
Sbjct: 903  SPVAS 907



 Score =  157 bits (396), Expect = 2e-37
 Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            IDA TES   T L +A   GH  +V  L+ R A     + K  TPL +AA AGH  V + 
Sbjct: 397  IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            LL     + A++ +   TPL  A   G   +V LLL   AN      + +TPL +AA  G
Sbjct: 456  LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            +V  +  LL    E +    +K G +PL +AA  G V   +LLL+  +  NA  + N  T
Sbjct: 515  HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      ++V LLL R  +    A  G TPL  AA     EV R LL  G   NA 
Sbjct: 572  PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
             V     T L +AA +GH +   LL+ + A+ ++ NK G TPL L +  GH  V  +L++
Sbjct: 632  SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             G  VDA      TPL  A   G++K+V++L++
Sbjct: 690  HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           E   +T  + A++ G+L+     L +G +++     G   L  A + GH  +   LL   
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
             LE  ++ G T L  AA AG    V+ L++ GANVN A +    T + +A    HL VV
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127

Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
           + LL +GA+     +DG T L  A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)

Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
            +V  R     T  + AA  G  +     L  G D+N      +    L +A+ +GH K  
Sbjct: 4    SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61

Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
              L+H+   ++   KKGNT L +A+  G  +VV+ LV  GA+V+A   +  TPL  A ++
Sbjct: 62   VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121

Query: 1369 GHVKVVQYLVK 1379
             H++VV++L++
Sbjct: 122  NHLEVVKFLLE 132



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)

Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
            + GL  L  A+  G+ ++   LL K  ++         +TAL IAA  G  +    L++ 
Sbjct: 43   QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100

Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
            GA+++ +++KG TPL++A+   H +VV+ L++ GA+ + A     TPL  A ++GH  VV
Sbjct: 101  GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160

Query: 1375 QYLV 1378
             +L+
Sbjct: 161  AHLI 164


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  225 bits (573), Expect = 5e-58
 Identities = 161/523 (30%), Positives = 261/523 (49%), Gaps = 46/523 (8%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D   L  A   G+ N V+ LLD G  ++  T +G + L     +G+ ++ ++LL   A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             +   G ++PL  A+ G +L+ V+LLL H+  V+  +    TAL  A   G   + KVL
Sbjct: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381
           L++ AN      NG TPL  A     ++V  +LL HGA I   +    ES LT   +A +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442

Query: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
            GH+++V  L+  GA          TAL  A   G  EV R L+  GAQV   A   ++P
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502

Query: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
           L ++A  G  ++   L+++GA+       GYTPL  +AREGHE++ A LL  GA+++  T
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562

Query: 502 EETQETALTLACCGGFSEVADFLIKAGAD---------------------------IELG 534
           ++   T L +A   G  EVA+ L++  A                            ++ G
Sbjct: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621

Query: 535 CS---------TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
            S         TPL  A+++  +++   LL  GA+ +A T  G  ++  A + GH D+  
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681

Query: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
           +LL   A++   ++ G TPL  AA+   +   + L+++GA+V+ A     +T + + C  
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD-AQTKMGYTPLHVGCHY 740

Query: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
           G++ +V  LL H A    + K+G T L +AA+ GHT++++ LL
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783



 Score =  220 bits (561), Expect = 1e-56
 Identities = 173/571 (30%), Positives = 280/571 (49%), Gaps = 32/571 (5%)

Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
           V   LD AA  L++ K   S  H A Q D            +N V+ LL     V++ T 
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365

Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
           +  + L +A   G+Y++A+VLL   AN   +   G  TPL  A     + +++LLL H A
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424

Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
            + + + +G T +  A   G V+IV  L++ GA+    N  G T L  AA +G  EV R 
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
           L+  GA +   + +  ++ L ++   G  D+V+ LL+ GA     T   +T L  +  +G
Sbjct: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
           H +VA  LLD GA +++      +PL +AA  G +E+A LL+++ A+ +     G TPL 
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603

Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
            AA   ++++  LLL QGA+ +A  +    T L +A      ++A  L++ GAD      
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662

Query: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
             +     A+QEGH+++V  LL   ANV+ +  +G T L  A +    +VA+VL+  GA 
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722

Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
           ++ +++ G TPL      G++  V FL+   A VN A   N +T +  A   GH  ++ +
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN-AKTKNGYTPLHQAAQQGHTHIINV 781

Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
           LL + A P     +G+T L  A + G+ +VV  L       ++  TT V++     + + 
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT--TTTVTE-----KHKM 834

Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALL 744
            VP      L M       D   + N+P +L
Sbjct: 835 NVPETMNEVLDM-----SDDEVRKANAPEML 860



 Score =  197 bits (501), Expect = 1e-49
 Identities = 157/498 (31%), Positives = 245/498 (49%), Gaps = 20/498 (4%)

Query: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257
           +H A Q+      E  ++ +    RK     R   + ++   S L  A  AG+ E A   
Sbjct: 2   AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60

Query: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
           +    ++ +  N+  +  L  AS  G++++V  LL  +A+V++ +  GNTAL  A   G 
Sbjct: 61  IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
            ++VKVL+  GAN+   ++NG TPL  AA   H+EV + LLD+GA   + + E   + L 
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178

Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
           +A  +GH  +V  LLE     + +   +H A  +       + A LLL +    ++ + S
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234

Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
             +PL +AA  G++ +A LL+ R A ++       TPL  A++ G+  MV LLL +GA I
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294

Query: 498 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 550
           +A+T +     LT   CG   G  +V + L+   A I    + G S PL  A+Q  HL  
Sbjct: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349

Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
           V+ LL     V   T    TAL  A   GH  VA VLL   A+   ++  G TPL  A +
Sbjct: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409

Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
              +  ++ L+  GA++ +A   +  T + +A   GH+ +V  L+ HGA P      G T
Sbjct: 410 KNRIKVMELLLKHGASI-QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468

Query: 671 MLIEAAKGGHTNVVSYLL 688
            L  AA+ G   VV YL+
Sbjct: 469 ALHMAARSGQAEVVRYLV 486



 Score =  171 bits (434), Expect = 6e-42
 Identities = 197/816 (24%), Positives = 347/816 (42%), Gaps = 97/816 (11%)

Query: 343  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402
            + AA AGH+E A   + +G  IN   N+   +AL LA  +GH+++V  LL+  A+ +  T
Sbjct: 46   LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104

Query: 403  DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462
             + +TAL  A + G  EV ++L+ +GA VN  + +  +PL +AA   H+E+   L++ GA
Sbjct: 105  KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164

Query: 463  NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 511
            +     ++G+TPL  A ++GH+++V+LLL             +I A+ ++T+  AL L  
Sbjct: 165  SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224

Query: 512  -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551
                             A   G   VA  L+   A ++       TPL  AS+ G+  +V
Sbjct: 225  DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284

Query: 552  KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
            K LL  GA + A T  G T L     +GH  V ++LL   A +  +++ G +PL  A + 
Sbjct: 285  KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344

Query: 612  GHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671
             HL  VQ L+     V+  T N+  T + +A   GH  V ++LL   A+P  +  +G T 
Sbjct: 345  DHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403

Query: 672  LIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMV----V 727
            L  A K     V+  LL +  ++ +V  + ++               P H  A +    +
Sbjct: 404  LHIACKKNRIKVMELLLKHGASIQAVTESGLT---------------PIHVAAFMGHVNI 448

Query: 728  PPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLN 787
              Q     +  N+         T+ +  ++L +A +        Y   +    E + K +
Sbjct: 449  VSQLMHHGASPNT---------TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 788  ELGQRISA-IEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQ 846
            +    ISA + KA +    L QG   N               +  + +   L      L 
Sbjct: 500  QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559

Query: 847  MKTQQQFTKEYLETK-GQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFS---ELPQVDTI 902
            + T++ FT  ++  K G+ +  +L  Q   +   P+  G   L   H +   +  +V  +
Sbjct: 560  ITTKKGFTPLHVAAKYGKLEVANLLLQ---KSASPDAAGKSGLTPLHVAAHYDNQKVALL 616

Query: 903  LFKDNDVDDEQQSPPSAEQIDFVPV--------QPLSSPQCNFSSDLGS---NGTNSLEL 951
            L       D+  SP +A +  + P+          +++    + +D  +    G  S+ L
Sbjct: 617  LL------DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670

Query: 952  QKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGS 1011
                G+  +V      + G +  + +    GL   TP        +D +      V  G+
Sbjct: 671  AAQEGHVDMVS----LLLGRNANVNLSNKSGL---TPLHLAAQ--EDRVNVAEVLVNQGA 721

Query: 1012 NSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELV 1071
            +  +QT    TP        N+   +   +  S  ++A T++ + T L  A   GH  ++
Sbjct: 722  HVDAQTKMGYTPLHVGCHYGNIKIVNF-LLQHSAKVNAKTKNGY-TPLHQAAQQGHTHII 779

Query: 1072 SVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
            +VL+  +A        G T L +A   G++ VV+ L
Sbjct: 780  NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815



 Score =  166 bits (421), Expect = 2e-40
 Identities = 137/467 (29%), Positives = 209/467 (44%), Gaps = 48/467 (10%)

Query: 944  NGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIA-- 1001
            NG N+L L    G+ ++V +            L+Q    +  AT        +  L    
Sbjct: 73   NGLNALHLASKEGHVEVVSE------------LLQREANVDAATKKGNTALHIASLAGQA 120

Query: 1002 -AVSTRVPTGSNSSSQTTECLTP----------ESCSQTTSNVASQSMPPVYPSVDIDAH 1050
              V   V  G+N ++Q+    TP          E       N ASQS+        +   
Sbjct: 121  EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 1051 TESNHDT-----------------ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLI 1093
             +  HD                  AL +A      +  ++L+  D   +   K GFTPL 
Sbjct: 181  LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240

Query: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153
            +AA  G++ V  +LL++   ++  + R   TPL +A   G   +V LLL RGA  + +  
Sbjct: 241  IAAHYGNINVATLLLNRAAAVDFTA-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299

Query: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
               TPL   A  G+  ++++LL+  A I S+T  K G+SPL +A    H+  V+LLL   
Sbjct: 300  DGLTPLHCGARSGHEQVVEMLLDRAAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHN 357

Query: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
              ++  +  +  TAL +A   G  +V  +LLD+KAN   +A  G TPL  A      +V 
Sbjct: 358  VPVD-DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416

Query: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
             +LL  GA + A  V  S  T + +AA  GH      L+H GA  +  N +G T L +A+
Sbjct: 417  ELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474

Query: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
              G  +VV+ LVQ GA V+A      TPL  + R G   +VQ L+++
Sbjct: 475  RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521



 Score =  157 bits (397), Expect = 1e-37
 Identities = 126/408 (30%), Positives = 196/408 (48%), Gaps = 48/408 (11%)

Query: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
            D   +S+ + +   A   GH E     I     I   ++ G   L LA+  GHV VV  L
Sbjct: 34   DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93

Query: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
            L +  +++A +++  +T L +A   G+ EVV +L+  GAN   ++ + +TPL +AA   +
Sbjct: 94   LQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152

Query: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD---------------- 1211
            + ++K LL+ GA  +  T    G +PL +A   GH   V LLL+                
Sbjct: 153  LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210

Query: 1212 -----------MGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
                       + +D NA +E+    T L +A   G   V +LLL+R A V+  A+  +T
Sbjct: 211  RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270

Query: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAH 1317
            PL  A+  G A + ++LLD+GA ++A     +RD  T L   A  GH +  E+L+ R A 
Sbjct: 271  PLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
            I  + K G +PL +A+ G H + VQLL+Q    VD   N  +T L  A   GH KV + L
Sbjct: 327  ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386

Query: 1378 V--------KEVNQF-PSDIECMRYIATITDKELLKKCHQCVETIVKA 1416
            +        K +N F P  I C +    I   ELL K    ++ + ++
Sbjct: 387  LDKKANPNAKALNGFTPLHIACKK--NRIKVMELLLKHGASIQAVTES 432



 Score =  151 bits (382), Expect = 7e-36
 Identities = 115/373 (30%), Positives = 180/373 (48%), Gaps = 37/373 (9%)

Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            I A TES   T + +A   GH  +VS L+   A     + +G T L +AA +G   VV  
Sbjct: 426  IQAVTESGL-TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
            L+  G  +EA++ +   TPL ++   G+ ++V  LL +GA+      S YTPL L+A  G
Sbjct: 485  LVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543

Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
            + ++   LL+ GA ++  T  K G +PL +AA  G +    LLL   +  +A  ++   T
Sbjct: 544  HEDVAAFLLDHGASLSITT--KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-T 600

Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
             L +A      +V  LLLD+ A+    AK G TPL  AA     ++   LL+ GAD NA 
Sbjct: 601  PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660

Query: 1287 P----------------------------VPSSRDTALT---IAADKGHYKFCELLIHRG 1315
                                         V  S  + LT   +AA +      E+L+++G
Sbjct: 661  TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720

Query: 1316 AHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQ 1375
            AH+D + K G TPL +  + G+  +V  L+Q  A V+A      TPL  A ++GH  ++ 
Sbjct: 721  AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780

Query: 1376 YLVKEVNQFPSDI 1388
             L++  N  P+++
Sbjct: 781  VLLQN-NASPNEL 792



 Score =  145 bits (366), Expect = 5e-34
 Identities = 114/369 (30%), Positives = 178/369 (48%), Gaps = 14/369 (3%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L ++   G  ++V  L+ + A        G+TPL L+A  GH  V   LLD G  +  
Sbjct: 501  TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560

Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
             +++   TPL +A   G+ EV +LLL + A+ +    S  TPL +AA      +  +LL+
Sbjct: 561  TTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619

Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
             GA  +    +K G +PL +AA    +     LL+ G+D NA +      ++ LA  +G 
Sbjct: 620  QGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGH 676

Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
             ++VSLLL R ANV    K+GLTPL  AA      V  VL+++GA V+A        T L
Sbjct: 677  VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--TPL 734

Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
             +    G+ K    L+   A ++ + K G TPL  A+  GH  ++ +L+Q  A  +    
Sbjct: 735  HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794

Query: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKA 1416
               T L  A R G++ VV  L K V +     E M    T+T+K  +    + +  ++  
Sbjct: 795  NGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKM-NVPETMNEVLDM 846

Query: 1417 KDQQAAEAN 1425
             D +  +AN
Sbjct: 847  SDDEVRKAN 855



 Score =  134 bits (337), Expect = 1e-30
 Identities = 105/317 (33%), Positives = 160/317 (50%), Gaps = 10/317 (3%)

Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
           D++ K+D  + + + A   GH+E A   + +G  +N+   +  + L LA+  GHVE+ + 
Sbjct: 34  DRKKKSDA-NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92

Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
           L++R AN++    +G T L  A+  G  E+V +L+  GAN+NAQ++    T L +A    
Sbjct: 93  LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF-TPLYMAAQEN 151

Query: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
             EV  FL+  GA   L      TPL  A Q+GH ++V  LL +             AL 
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP----ALH 207

Query: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
            A     T  A +LLQ   + + ES+ G TPL  AA  G++     L+++ A V+  TA 
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTAR 266

Query: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
           ND T + +A   G+  +V+LLL  GA    + +DG T L   A+ GH  VV  LLD    
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 694 VLSVPTTDVSQLPPPSQ 710
           +LS     +S L   +Q
Sbjct: 327 ILSKTKNGLSPLHMATQ 343



 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 65/203 (32%), Positives = 99/203 (48%), Gaps = 15/203 (7%)

Query: 1061 LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120
            LA   GH ++VS+L+ R+A +   +K G TPL LAA    V V E+L+++G  ++AQ++ 
Sbjct: 670  LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729

Query: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1180
               TPL + C  G  ++V+ LL   A    +  + YTPL  AA  G+ +II +LL   A 
Sbjct: 730  GY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788

Query: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
             N  T +  G + L +A   G++  V  L  +        ET   T +T        E +
Sbjct: 789  PNELTVN--GNTALGIARRLGYISVVDTLKIVTE------ETMTTTTVTEKHKMNVPETM 840

Query: 1241 SLLLD------RKANVEHRAKTG 1257
            + +LD      RKAN       G
Sbjct: 841  NEVLDMSDDEVRKANAPEMLSDG 863



 Score = 35.4 bits (80), Expect = 0.72
 Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 16/181 (8%)

Query: 1932 SCPITVSSVVAAS-QQLCVTNTRTPSSVRKQLFACVPKTSP-PATVISSVTSTCSSLPSV 1989
            + PITV     +    L  +++ TPS+   +    V   SP  +T+ +S TS+  S+  V
Sbjct: 1508 TAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDV 1567

Query: 1990 SSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMANLCTPSSTAN 2049
            +S PI S +  ++ +    SQ+  + Q      A  P      T+  P+  L   S++  
Sbjct: 1568 AS-PIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAV----TEATPLKGLA--SNSTF 1620

Query: 2050 SCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTS 2109
            S  +S   T G+     S + TP +S       P S  ++   S+PF S    A   ++S
Sbjct: 1621 SSRTSPVTTAGSLLERSSITMTPPAS-------PKSNINMYSSSLPFKSIITSAAPLISS 1673

Query: 2110 P 2110
            P
Sbjct: 1674 P 1674



 Score = 35.4 bits (80), Expect = 0.72
 Identities = 36/140 (25%), Positives = 60/140 (42%), Gaps = 13/140 (9%)

Query: 2050 SCSSSASNTPGAPETHPS---SSPTPTSSNTQEEAQPSSVSDLSPMSMP---FASNSEPA 2103
            S SSS+SNTP A         S+P+P  S T   +  SSV  +S ++ P   F + S P 
Sbjct: 1523 SLSSSSSNTPSASPLKSIWSVSTPSPIKS-TLGASTTSSVKSISDVASPIRSFRTMSSPI 1581

Query: 2104 PLTLT-SPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVT 2162
               ++ SP  +   +   +  P +    P     +    +F S     T      S+   
Sbjct: 1582 KTVVSQSPYNIQVSSGTLARAPAVTEATPLKG--LASNSTFSSRTSPVTT---AGSLLER 1636

Query: 2163 NPVTLTPPQGPPAAVQLSSA 2182
            + +T+TPP  P + + + S+
Sbjct: 1637 SSITMTPPASPKSNINMYSS 1656


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  184 bits (467), Expect = 1e-45
 Identities = 126/379 (33%), Positives = 198/379 (52%), Gaps = 6/379 (1%)

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
           +  +K LL +  ++++ NE G TPLM AA  G++E+ + L+ +GA  N    +   +AL 
Sbjct: 18  IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76

Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
            A  +GH+ +V  LL+ G + EH+     TALM AC  G  +V  LLL  GA  ++    
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
              P+  AA  GH ++  LL++ GA +   +  G TPL+ AAR+GH E V  LLA GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554
           + Q      TAL +A  GG+++    ++K   ++ L     +T LM AS+EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255

Query: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614
           L +G  V+    +GDT L  A   GH ++   LLQ  AD++   +  +T L  A   G+ 
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315

Query: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
             V+ ++    +    T + +  ++  A    ++ VVELLL  GA  +   K G T L  
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIK-ATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374

Query: 675 AAKGGHTNVVSYLLDYPNN 693
           A +G    +   LL  P +
Sbjct: 375 AIRGRSRKLAELLLRNPKD 393



 Score =  169 bits (427), Expect = 4e-41
 Identities = 119/376 (31%), Positives = 188/376 (50%), Gaps = 6/376 (1%)

Query: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347
           +K LL    DV+ ++  G T L  A   G ++IVK L+  GAN    + +  T L+ A+ 
Sbjct: 21  LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80

Query: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407
            GHV +   LL  G  +  H +    +AL  ACYKG  D+V  LL  GA+          
Sbjct: 81  EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139

Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
            ++ A   GH ++  LLL +GA+VN       +PL  AA  GH+E    L+  GA++++ 
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199

Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
                T L+ A + G+ + V  +L +  N+N  T++   TAL +A   G +E+   L+ A
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258

Query: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
           G  + +      T L+ A + GH+E+V+ LL   A++        TAL +A E G+  + 
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318

Query: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
             +LQ   D E  ++ G TPL+KA +  ++  V+ L+ KGA V+      D T + +A  
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLHIAIR 377

Query: 645 GGHLAVVELLLAHGAD 660
           G    + ELLL +  D
Sbjct: 378 GRSRKLAELLLRNPKD 393



 Score =  166 bits (419), Expect = 4e-40
 Identities = 122/357 (34%), Positives = 179/357 (50%), Gaps = 12/357 (3%)

Query: 1027 SQTTSNVASQSMPPVYPSV-----DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKI 1081
            SQ+  N   +   P   ++     D+D   E    T L +A   G+ E+V  LI   A  
Sbjct: 6    SQSVINYVEEENIPALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANC 64

Query: 1082 EHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141
               D   +T LI A+  GHV +VE LL  G ++E   +    T L  AC  GR +VV+LL
Sbjct: 65   NLEDLDNWTALISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELL 123

Query: 1142 LARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG 1201
            L+ GAN     +    P+  AA  G+ +I+ +LL  GA++N     K G +PL+ AA  G
Sbjct: 124  LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKG 181

Query: 1202 HVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261
            H+  VK LL MG+D++ Q   N  TAL +A   G  + V  +L R  NV    K G T L
Sbjct: 182  HLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240

Query: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321
            M A+  G+ E+ + LLD G  VN P    S DT L  A   GH +    L+ + A ID+R
Sbjct: 241  MIASKEGHTEIVQDLLDAGTYVNIP--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298

Query: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
             +   T L+ A   G+  +V+ ++Q   D +       TPL+ A +  +++VV+ L+
Sbjct: 299  GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355



 Score =  138 bits (347), Expect = 8e-32
 Identities = 102/310 (32%), Positives = 161/310 (51%), Gaps = 9/310 (2%)

Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
           ++  ++ LLE   D + + +   T LM A   G++E+ + L+ +GA  N+      + L 
Sbjct: 17  NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76

Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            A+  GHV +   L++ G NLE  +  G+T LM A  +G  ++V LLL+ GAN +  T  
Sbjct: 77  SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135

Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558
                +  A   G +++   L++ GA  ++ CS     TPL+ A+++GHLE VK+LLA G
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193

Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
           A+V    A   TAL  A + G+T     +L+   ++    + G T LM A++ GH   VQ
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253

Query: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
            L+  G  VN    + D TV+  A  GGH+ +V  LL   AD   R +D  T L  A + 
Sbjct: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312

Query: 679 GHTNVVSYLL 688
           G+  +V  +L
Sbjct: 313 GNATMVRDIL 322



 Score =  133 bits (335), Expect = 2e-30
 Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 17/354 (4%)

Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
            ++  ++ LL+K  D++ ++E    TPL +A   G  E+V  L+  GAN    ++ ++T L
Sbjct: 17   NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75

Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
              A+  G+V+I++ LL  G  +  R     G + LM A   G    V+LLL  G++ +  
Sbjct: 76   ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132

Query: 1220 IETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
              T   +   +  A  +G A++V LLL   A V    K G TPL+ AA  G+ E  + LL
Sbjct: 133  --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190

Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
              GADV+     S   TAL +A   G+ +  + ++ R  ++++ +K GNT L +AS  GH
Sbjct: 191  AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248

Query: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSDIECMRYI 1394
             ++VQ L+ AG  V+  D    T L+ A R GHV++V+ L++   +++    D +   Y 
Sbjct: 249  TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308

Query: 1395 A----TITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
            A      T    + +C+   E   K  +    +A K  +I + EL L+K  + S
Sbjct: 309  AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362



 Score =  122 bits (305), Expect = 6e-27
 Identities = 88/284 (30%), Positives = 142/284 (50%), Gaps = 2/284 (0%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           +L  AC  G  + V  LL  G + +         +  A   G+ ++  +LL   A V + 
Sbjct: 107 ALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV-NC 165

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
            +K   TPL+ A+  G+L+ VK LL   ADV+ + A   TAL  A  GG+   VK +L  
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
             N+   +++G+T LM A+  GH E+ + LLD G  +N   +   ++ L  A   GH+++
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEI 284

Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
           VR LL+  AD + +  +  TAL  A   G+  + R +L       +     E+PL  A  
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344

Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
             ++E+  LL+++GA +  V+ +G TPL  A R    ++  LLL
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388



 Score =  121 bits (304), Expect = 8e-27
 Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)

Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
            A   GH ++V +L+   AK+   DK G TPL+ AA  GH+  V+ LL  G D++ +   +
Sbjct: 144  AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203

Query: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
              T L +A  GG  + V  +L R  N    +    T L +A+  G+  I++ LL+AG  +
Sbjct: 204  M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262

Query: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
            N     + G + L+ A   GHV  V+ LL   +DI+ + + N+ TAL  A  +G A +V 
Sbjct: 263  N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319

Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
             +L    + E   K G TPL++A      EV  +LLDKGA V+A  V    DT L IA  
Sbjct: 320  DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377

Query: 1302 KGHYKFCELLIHR---GAHIDVRNKKGNTP 1328
                K  ELL+     G  +   NK G TP
Sbjct: 378  GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 73/198 (36%), Positives = 98/198 (49%), Gaps = 4/198 (2%)

Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 556
           +  E  +T L +A   G  E+   LIK GA+    +L   T L+ AS+EGH+ +V+ LL 
Sbjct: 33  ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLK 92

Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
            G N+      G TAL +AC  G TDV ++LL  GA+          P++ AA  GH   
Sbjct: 93  CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADI 152

Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
           V  L+  GA VN  +     T +  A   GHL  V+ LLA GAD      +  T LI A 
Sbjct: 153 VHLLLQNGAKVN-CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAV 211

Query: 677 KGGHTNVVSYLLDYPNNV 694
           KGG+T  V  +L    NV
Sbjct: 212 KGGYTQSVKEILKRNPNV 229



 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 5/194 (2%)

Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
            +N  TAL +A  GG+ + V  ++ R+  +   DK G T L++A+  GH  +V+ LLD G 
Sbjct: 201  ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260

Query: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
             +    +R+ DT L  A  GG  E+V  LL + A+ + R   + T L  A   G   +++
Sbjct: 261  YVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319

Query: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
             +L    +    T  K G +PL+ A    ++  V+LLLD G+ ++A ++   +T L +A 
Sbjct: 320  DILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA- 375

Query: 1233 FQGRAEVVSLLLDR 1246
             +GR+  ++ LL R
Sbjct: 376  IRGRSRKLAELLLR 389



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 1/145 (0%)

Query: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603
           +E ++  +K LL    +V      G T L  A E G+ ++   L++ GA+   E     T
Sbjct: 14  EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73

Query: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663
            L+ A++ GH+  V+ L+  G N+         T +  AC  G   VVELLL+HGA+P+ 
Sbjct: 74  ALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLLSHGANPSV 132

Query: 664 RLKDGSTMLIEAAKGGHTNVVSYLL 688
                   +I AA  GH ++V  LL
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLL 157



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 51/168 (30%), Positives = 82/168 (48%), Gaps = 6/168 (3%)

Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
            P+V++   T+ + +TAL +A   GH E+V  L+     +   D+ G T LI A   GHV 
Sbjct: 227  PNVNL---TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283

Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
            +V  LL K  DI+ + +  K T L  A   G   +V  +L    + E       TPL  A
Sbjct: 284  IVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKA 342

Query: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
                 + ++++LL+ GA++++    K G +PL +A         +LLL
Sbjct: 343  TKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAELLL 388



 Score = 36.2 bits (82), Expect = 0.42
 Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)

Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
           GQ +  +L  A   G+   VR +L         T++GE+ L  A      E+ ++LL   
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358

Query: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297
           A V     KGD TPL  A  G    + +LLL +  D
Sbjct: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  180 bits (456), Expect = 2e-44
 Identities = 146/497 (29%), Positives = 235/497 (47%), Gaps = 29/497 (5%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266
           L  A +     AV+ L+     VN   +  ++ L +A +    + A+V++ +    NV D
Sbjct: 53  LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112

Query: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
           RG +   T L  A+  G++++V LLL   A++N+       AL +A   G +D+V +L+N
Sbjct: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            GA +   ++ G+TPL  AAS G + V + LL+ G  I+   N +  +AL +ACY G   
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445
           +V  L++ GA+     +   T L  A    H  +   LL+++GA VN+ +   +SPL + 
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288

Query: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
           A  G    +  LI+ G  ++ V+ +G TPL  AAR GHE ++  L   GA+  A+     
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347

Query: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562
              L LA     S+    L+ +G +I+       T L  A+  G++E +K L +SGA+ H
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407

Query: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
                G T L YA  N H    + L+  GA++    + GRT L  AA            +
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA------------A 455

Query: 623 KGANVNRATANNDHTVVSLACAGGHL------AVVELLLAHGADPTHRLKDGSTMLIEAA 676
              + N+    N H           L        +E LL + A+P+ R K+G   +  AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515

Query: 677 KGGHTNVVSYLLDYPNN 693
             GH   +  LL+  N+
Sbjct: 516 AYGHRQCLELLLERTNS 532



 Score =  170 bits (430), Expect = 2e-41
 Identities = 137/457 (29%), Positives = 221/457 (48%), Gaps = 8/457 (1%)

Query: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
           L+ +   VN    E  + L +A   G  E+ ++L+   A V  + N   +TPL  A +  
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60

Query: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
             + V++L+ H ADVN++     T L  A A   V   +V++   +++   +  G T L 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
            AA  GHVE+  +LL  GA IN    + +  AL  A Y GHLD+V  L+  GA+   K  
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
           + +T L  A  +G + V + LL+ G +++       + L +A   G   +   LI+ GAN
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239

Query: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
           + + N+ G+TPL  AA   H  + + LL+  GA++N Q+++ +      A  G F+  + 
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298

Query: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
            LI+ G +I+      +TPL  A++ GH  L+  L  SGA+           L  A  N 
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358

Query: 580 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVV 639
           H+D    LL +G +++   + GRT L  AA  G++  ++ L S GA+ ++       T +
Sbjct: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD-KCGRTPL 417

Query: 640 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
             A A  H   +E L+  GA+       G T L  AA
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454



 Score =  167 bits (423), Expect = 1e-40
 Identities = 158/559 (28%), Positives = 243/559 (43%), Gaps = 71/559 (12%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
           +L  A  +G V  V  LL +G ++N   ++    L  A   G+ ++  +L+   A V  +
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177

Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
             KG  TPL AA+S G +++VK LL    +++  +  GNTAL  AC  G   +V  L++ 
Sbjct: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236

Query: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKE------------- 373
           GAN+   N NG TPL  AA++ H  +   +L+++GA +N  S + K              
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 374 -------------------SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
                              + L +A   GH  ++  L  +GAD           L  A +
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356

Query: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
           + H +  R LL SG +++ P     + L  AA GG+VE   LL   GA+  + +  G TP
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE--------------- 519
           L  AA   H   +  L+  GAN+N +T++   TAL  A                      
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475

Query: 520 -------------VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHA 563
                          +FL++  A+  +        +  A+  GH + ++ LL    +   
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535

Query: 564 TTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
            + +G T   L  A  NGH    +VLLQ+  DL+   E GRT L  AA  GH   V+ LI
Sbjct: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595

Query: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKD--GSTMLIEAAKG 678
           + GA++         T +  +   GH   + LLL    +P    +KD  G T L+ A   
Sbjct: 596 NPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAY 655

Query: 679 GHTNVVSYLLDYPNNVLSV 697
           GH + VS LL+   NV +V
Sbjct: 656 GHIDAVSLLLEKEANVDTV 674



 Score =  149 bits (377), Expect = 3e-35
 Identities = 124/425 (29%), Positives = 195/425 (45%), Gaps = 7/425 (1%)

Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
           TPL  A+  G  +I++LL+L  A VN++     T L  A A    + V+VL+   A++  
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
            ++N  TPL  AA+   V+ A V++   + +N  S+    +AL  A   GH++MV  LL 
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136

Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
            GA+      +   AL  A   GH++V  LL++ GA+V        +PL  AA  G + +
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196

Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
              L+  G  ++E+N  G T L  A   G + +V  L+  GAN+N Q      T L  A 
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255

Query: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569
                 +  + L+  GAD+ +      +PL   +  G     + L+ +G  +      G+
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
           T L  A   GH  + + L  +GAD          PL  AA   H    + L+S G  ++ 
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID- 374

Query: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
                  T +  A AGG++  ++LL + GAD   + K G T L  AA   H + +  L+ 
Sbjct: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434

Query: 690 YPNNV 694
              NV
Sbjct: 435 TGANV 439



 Score =  142 bits (359), Expect = 3e-33
 Identities = 108/322 (33%), Positives = 158/322 (49%), Gaps = 40/322 (12%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L  A A   EE V VLI   A +  RDK   TPL +AA    V   E+++     +  
Sbjct: 51   TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110

Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
             S+R   T L  A   G  E+V+LLLA+GAN    +  D   L  AA  G+++++ +L+N
Sbjct: 111  -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169

Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
             GAE+  +   K G +PL  AA NG +  VK LL++G +I+ +I    NTAL +AC+ G+
Sbjct: 170  HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226

Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
              VV+                                  L+D GA+VN P   ++  T L
Sbjct: 227  DAVVN---------------------------------ELIDYGANVNQPN--NNGFTPL 251

Query: 1297 TIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
              AA   H   C ELL++ GA +++++K G +PL + +  G F   Q L+Q G ++D  D
Sbjct: 252  HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311

Query: 1356 NRKITPLMSAFRKGHVKVVQYL 1377
                TPL  A R GH  ++  L
Sbjct: 312  KDGNTPLHVAARYGHELLINTL 333



 Score =  141 bits (355), Expect = 9e-33
 Identities = 117/402 (29%), Positives = 186/402 (46%), Gaps = 8/402 (1%)

Query: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
           +L+H   DVN+  +   T L  A   G  +I+++L+  GA +   +    TPL  A ++ 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
             E  +VL+ H A +N     + ++ L +A     +     ++   +          TAL
Sbjct: 61  SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119

Query: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
             A ++GHVE+  LLL  GA +N         L  AA  GH+++ ALLI  GA +   + 
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179

Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
           +GYTPL  AA  G   +V  LL  G  I+ +      TAL +AC  G   V + LI  GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238

Query: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
           ++    +   TPL  A+   H  L ++ L+ +GA+V+  +  G + L     +G    + 
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298

Query: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
            L+Q G +++   + G TPL  AAR GH   +  L + GA+  +   ++    + LA   
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357

Query: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
            H      LL+ G +     K G T L  AA GG+   +  L
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399



 Score =  138 bits (348), Expect = 6e-32
 Identities = 142/515 (27%), Positives = 228/515 (44%), Gaps = 25/515 (4%)

Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
           L +    + H   +     L  A ++   + +  L+  G +VNE  + G + L  A ++ 
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457

Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
                 +L   H N E+     ++    A         ++ LL +DA+ + +   G  ++
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511

Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367
            YA A G    +++LL    +  + +++G T  PL  AA  GH +   VLL     ++  
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571

Query: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425
            +E   +AL LA +KGH + V  L+  GA    K +    T L  + ++GH    RLLL 
Sbjct: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630

Query: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
             D+   V++     ++PL LA   GH++  +LL+E+ AN++ V+  G T L      GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690

Query: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS------T 537
           EE V +LL Q  +I  + +    T L  A   G +     L++     E  C       T
Sbjct: 691 EECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA--GADLE 595
           PL  A   G+   ++ LL              T L  A  N H + A +LL A   + + 
Sbjct: 750 PLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808

Query: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655
              + GRTPL  AA A H+  +Q L+   A VN A  N+  T + +A   G    V++L+
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILV 867

Query: 656 -AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
            +  AD T + KD +T L  A   GH      +LD
Sbjct: 868 NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902



 Score =  134 bits (337), Expect = 1e-30
 Identities = 119/408 (29%), Positives = 183/408 (44%), Gaps = 32/408 (7%)

Query: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
           D  +K   T L AA++GG ++ +KLL    AD + +   G T L YA A      ++ L+
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433

Query: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALT 377
             GAN+ + ++ G T L  AA A  ++  + +L      N H N        E KE   T
Sbjct: 434 TTGANVNETDDWGRTALHYAA-ASDMDRNKTILG-----NAHDNSEELERARELKEKEAT 487

Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
           L         + FLL+  A+   +  E + ++  A   GH +   LLL+        +DS
Sbjct: 488 LC--------LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539

Query: 438 --FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
              +SPL LAA  GH +   +L++   +L+  +++G T L  AA +GH E V  L+  GA
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599

Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEGHLE 549
           +I  +   T+ T L  +   G +     L++   + E          TPLM A   GH++
Sbjct: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659

Query: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
            V  LL   ANV      G TAL      GH +   +LL+    +  +   GRTPL  AA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719

Query: 610 RAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLL 655
             GH   +  L+    +        N  +T +  AC  G+   +E+LL
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767



 Score =  129 bits (325), Expect = 3e-29
 Identities = 139/522 (26%), Positives = 220/522 (42%), Gaps = 43/522 (8%)

Query: 222 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASS 281
           RKLL  G  ++   + G + L  A + G  E  ++L +  A+   +   G  TPL  A++
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYAAA 422

Query: 282 GGYLDIVKLLLLHDADVNSQSATGNTALTYACA----------GGFVD------------ 319
             +   ++ L+   A+VN     G TAL YA A          G   D            
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482

Query: 320 ------IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFK 372
                  ++ LL   AN    ++ G+  +  AA+ GH +   +LL+   +G     +   
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542

Query: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
           +S L LA Y GH   +  LL++  D + + ++  TAL  A   GH E    L++ GA + 
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602

Query: 433 MPAD-SFESPLTLAACGGHVELAALLIERGANLEEVN---DEGYTPLMEAAREGHEEMVA 488
           +  + +  +PL  +   GH     LL+E   N E V+    +G TPLM A   GH + V+
Sbjct: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662

Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545
           LLL + AN++   +    TAL      G  E    L++    I    S   TPL  A+  
Sbjct: 663 LLLEKEANVDT-VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721

Query: 546 GHLELVKYLLA---SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
           GH   +  LL    S  +       G T L +AC NG+ +  +VLL+     +       
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF- 780

Query: 603 TPLMKAARAGH-LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
           TPL  A    H  C    L +  +++     +   T +  A    H+  ++LLL H A  
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840

Query: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
                 G T L+ AA+ G    V  L++     L+V   D++
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882



 Score =  120 bits (301), Expect = 2e-26
 Identities = 113/357 (31%), Positives = 158/357 (44%), Gaps = 24/357 (6%)

Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
            L LA   GH + + VL+     ++ RD+KG T L LAA  GH   VE L++ G  I  + 
Sbjct: 546  LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
              TK TPL  +   G    + LLL    N E  +V D    TPL LA + G+++ + +LL
Sbjct: 606  NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
                E N  T   LG + L    M GH   V++LL+    I  + ++   T L  A  +G
Sbjct: 666  E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722

Query: 1236 RAEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
             A  +S LL    + E    +   G TPL  A   G      VLL++         P   
Sbjct: 723  HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780

Query: 1293 DTALTIAADKGHYKFCELLIHR--GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
             T L  A    H     LL+     + +  R+ KG TPL  A+   H + +QLL++  A 
Sbjct: 781  -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839

Query: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCH 1407
            V+A DN   T LM A   G    V  L   VN   +D+       T+ DK+L    H
Sbjct: 840  VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQADL-------TVKDKDLNTPLH 886



 Score =  108 bits (269), Expect = 9e-23
 Identities = 107/384 (27%), Positives = 164/384 (42%), Gaps = 64/384 (16%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
            +TAL +AC  G + +V+ LI   A +   +  GFTPL  AA + H  + +E+L++ G D+
Sbjct: 215  NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274

Query: 1115 EAQSERTK--------------------------------DTPLSLACSGGRQEVVDLLL 1142
              QS+  K                                +TPL +A   G + +++ L 
Sbjct: 275  NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334

Query: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
              GA+     +    PL LAA   + +  + LL++G EI+  T  K G + L  AA  G+
Sbjct: 335  TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID--TPDKFGRTCLHAAAAGGN 392

Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
            V  +KLL   G+D + + +  R T L  A        +  L+   ANV      G T L 
Sbjct: 393  VECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALH 451

Query: 1263 EAASGGY----------------AEVGRVLLDKGADV------NAPPVPSSRD----TAL 1296
             AA+                    E  R L +K A +           PS RD     ++
Sbjct: 452  YAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSI 511

Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNT--PLWLASNGGHFDVVQLLVQAGADVDAA 1354
              AA  GH +  ELL+ R       +  G T  PL LA+  GH   +++L+Q+  D+D  
Sbjct: 512  HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571

Query: 1355 DNRKITPLMSAFRKGHVKVVQYLV 1378
            D +  T L  A  KGH + V+ L+
Sbjct: 572  DEKGRTALDLAAFKGHTECVEALI 595



 Score =  101 bits (252), Expect = 8e-21
 Identities = 90/316 (28%), Positives = 151/316 (47%), Gaps = 12/316 (3%)

Query: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK--GGDIEAQSERTKDTPLSLACS 1131
            L+  DA    RDK+G+  +  AA  GH   +E+LL++   G  E+ S  TK +PL LA  
Sbjct: 493  LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAAY 551

Query: 1132 GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191
             G  + +++LL    + + R+    T L LAA  G+   ++ L+N GA I  +  +    
Sbjct: 552  NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKR 610

Query: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINA--QIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
            +PL  + +NGH   ++LLL++  +  A    +    T L LA   G  + VSLLL+++AN
Sbjct: 611  TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
            V+     G T L      G+ E  ++LL++  +V+     S   T L  AA +GH  +  
Sbjct: 671  VDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGHATWLS 728

Query: 1310 LLIHRGAHID---VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAF 1366
             L+      +    ++ +G TPL  A   G+ + +++L++         N   TPL  A 
Sbjct: 729  ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN-PFTPLHCAI 787

Query: 1367 RKGHVKVVQYLVKEVN 1382
               H      L+  ++
Sbjct: 788  INDHGNCASLLLGAID 803



 Score =  100 bits (249), Expect = 2e-20
 Identities = 72/222 (32%), Positives = 117/222 (52%), Gaps = 5/222 (2%)

Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
            TPL +AA  G   II++L+ +GA +N++    + ++PL  A  +    AV++L+   +D+
Sbjct: 18   TPLHVAAFLGDAEIIELLILSGARVNAK--DNMWLTPLHRAVASRSEEAVQVLIKHSADV 75

Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
            NA+ + N  T L +A      +   +++   ++V    + G T L  AA  G+ E+  +L
Sbjct: 76   NAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134

Query: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
            L KGA++NA      R  AL  AA  GH     LLI+ GA +  ++KKG TPL  A++ G
Sbjct: 135  LAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192

Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
              +VV+ L+  G ++D  +    T L  A   G   VV  L+
Sbjct: 193  QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 66/206 (32%), Positives = 104/206 (50%), Gaps = 5/206 (2%)

Query: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
            +L++   ++N+    K   +PL +AA  G    ++LL+  G+ +NA+ +    T L  A 
Sbjct: 1    MLIHKTEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAV 57

Query: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
                 E V +L+   A+V  R K   TPL  AA+    +   V++   + VN        
Sbjct: 58   ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD--RGG 115

Query: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
             TAL  AA  GH +   LL+ +GA+I+  +KK    L  A+  GH DVV LL+  GA+V 
Sbjct: 116  RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175

Query: 1353 AADNRKITPLMSAFRKGHVKVVQYLV 1378
              D +  TPL +A   G + VV++L+
Sbjct: 176  CKDKKGYTPLHAAASNGQINVVKHLL 201



 Score = 89.0 bits (219), Expect = 6e-17
 Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 14/250 (5%)

Query: 1044 SVDIDAHTESNHDTALTLACAG-------GHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
            +V +    E+N DT   L C         GHEE V +L+ ++  I  +D +G TPL  AA
Sbjct: 660  AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719

Query: 1097 TAGHVGVVEILLDKGGDIE--AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
              GH   +  LL      E     +    TPL  AC  G +  +++LL +   ++    +
Sbjct: 720  ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778

Query: 1155 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
             +TPL  A    + N   +LL A  + I S    K G +PL  AA   HV  ++LLL   
Sbjct: 779  PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837

Query: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1272
            + +NA ++ +  TAL +A   G+A  V +L++  +A++  + K   TPL  A S G+ + 
Sbjct: 838  APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896

Query: 1273 GRVLLDKGAD 1282
              ++LDK  D
Sbjct: 897  ALLILDKIQD 906



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 9/279 (3%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            ++   T L LA A GH + VS+L+ ++A ++  D  G T L      GH   V++LL++ 
Sbjct: 642  DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE---HRNVSDYTPLSLAASGGYV 1168
              I  +  R + TPL  A + G    +  LL    ++E    ++   YTPL  A   G  
Sbjct: 702  VSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760

Query: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQIETNRNTA 1227
            N I++LL          G+    +PL  A +N H     LLL  + S I +  +    T 
Sbjct: 761  NCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817

Query: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287
            L  A F    E + LLL   A V     +G T LM AA  G A    +L++  A  +   
Sbjct: 818  LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQADLTV 876

Query: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326
                 +T L +A  KGH K   L++ +     + N+K N
Sbjct: 877  KDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 38/285 (13%)

Query: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
           ++ D   +V+    +G++ L LA + G+ +   +LL   ANV+     G  T L      
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688

Query: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339
           G+ + V++LL  +  +  + + G T L YA A G    +  LL    + ED    +  G+
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748

Query: 340 TPLMEAASAGHVEVARVLLD---------------HGAGINTHSN--------------- 369
           TPL  A   G+     VLL+               H A IN H N               
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808

Query: 370 ---EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
              +   + L  A +  H++ ++ LL   A      +   TALM A  +G      +L++
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868

Query: 427 SG-AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
           S  A + +      +PL LA   GH + A L++++  +   +N++
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 73/294 (24%), Positives = 112/294 (38%), Gaps = 78/294 (26%)

Query: 192 RMKAENSHNAGQVDTRS------LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLA 245
           R+  E + N   VD +       L  A + G ++AV  LL++  +V+     G + L   
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRG 685

Query: 246 CSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQS 302
              G+ E  Q+LL    ++  + ++G  TPL  A++ G+   +  LL   L + D   + 
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKD 744

Query: 303 ATGNTALTYACAGGFVDIVKVLLNEG---------------ANIEDH------------- 334
             G T L +AC  G  + ++VLL +                A I DH             
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS 804

Query: 335 ------NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK---------------- 372
                 ++ G TPL  AA A HVE  ++LL H A +N   N  K                
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 864

Query: 373 -----------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
                             + L LAC KGH      +L+   D E   +E + AL
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 9/108 (8%)

Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
            +LIH+   ++  + +  TPL +A+  G  ++++LL+ +GA V+A DN  +TPL  A    
Sbjct: 1    MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 1370 HVKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
              + VQ L+K   +VN    + +   ++A         K  +C E I+
Sbjct: 61   SEEAVQVLIKHSADVNARDKNWQTPLHVAA------ANKAVKCAEVII 102


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  169 bits (427), Expect = 4e-41
 Identities = 163/602 (27%), Positives = 258/602 (42%), Gaps = 98/602 (16%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D   L +A    DV  VR LL +  ++N   +E  + L  A   G   + Q+LL   ANV
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             +     +TPL  A++     ++ LLL H ADVN++     T L  A A       + L
Sbjct: 68  NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126

Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
               +++   + +G + L  A  +GH+E   +LL+ GA +N    + ++  L  A + GH
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185

Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
           L++++ L+  GAD   K  + +  L  A   G +EV + LL  GA+++ P     + L +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245

Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503
           A   G   +A  L+  GAN+ + ND+G+TPL  AA   +  + + LL+  GA++N Q++E
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305

Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGA- 559
            +      A  G F+  +  LI+ G++I+      +TPL  A++ GH  L+  L+ +GA 
Sbjct: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364

Query: 560 -----------------------------------------NVHATTA---------TGD 569
                                                    N H  +A          G 
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424

Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
           T L  A   G+ +  ++LL +GADL    + GRTPL  AA  G       L++ GA VN 
Sbjct: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484

Query: 630 -----------ATANNDHTVVSLACAGGHLA----------------VVELLLAHGADPT 662
                      A A++ +          H A                 +E LL +GADP+
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544

Query: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722
            R + G T +  AA  G+   +  LL+   N L     DV         +S +P  P H 
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DV---------ESTIPVSPLHL 591

Query: 723 LA 724
            A
Sbjct: 592 AA 593



 Score =  143 bits (360), Expect = 2e-33
 Identities = 162/634 (25%), Positives = 249/634 (39%), Gaps = 106/634 (16%)

Query: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177
           E+     A GADL   D +    L     AA  G++         G    +P        
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243

Query: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233
            ++C L + A A+  + A    N  Q + +        A S      +  L++ G  VN 
Sbjct: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301

Query: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292
            ++EG+S L +A   G +  +Q+L+   + + D  +K   TPL  A+  G+  ++  L+ 
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360

Query: 293 ---------LHDA-----------------------------------------DVNSQS 302
                    +HD                                          D+N+  
Sbjct: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420

Query: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
             G T L  A +GG V+ + +LL+ GA++   ++ G TPL  AA+ G  + A  L+  GA
Sbjct: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480

Query: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394
           G+N                            +H  E ++  L  +  K     + FLL+ 
Sbjct: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539

Query: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452
           GAD   +  + +TA+  A   G+ +   LLL+         +S    SPL LAA  GH E
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
               L E   NL+  + +G T L  A   G  E V +L A GA+   +  + + T L  A
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659

Query: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
              G ++    LI +G  ADI    +    TPLM A   GH++ V  LL  G+   A   
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719

Query: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
            G TAL      G  D    LL   A +      GRTP+  A+  GH   ++ L+    +
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779

Query: 627 VNRATANNDHTVVS---LACAGGHLAVVELLLAH 657
            +   A  D++  S    A   GH   +ELLL H
Sbjct: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score =  142 bits (358), Expect = 4e-33
 Identities = 161/543 (29%), Positives = 230/543 (42%), Gaps = 60/543 (11%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  A + G +  V+ LL  G  ++E    G + L +AC  G   +A  L+   ANV    
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269

Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
           +KG  TPL   A S+ G L  ++LL+ + ADVN QS  G + L  A   G     ++L+ 
Sbjct: 270 DKG-FTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            G+ I+  ++ G+TPL  AA  GH  +   L+ +GA             L LA   G  D
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSD 386

Query: 387 MVRFLLEAG--------ADQEH---------KTDEM-HTALMEACMDGHVEVARLLLDSG 428
             R LL +G           EH           D +  T L  A   G+VE   LLL SG
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-------RE 481
           A +        +PL  AA  G  + A  L+  GA + E + +G +PL  AA        E
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506

Query: 482 GH-------EE--------------MVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
            H       EE               +  LL  GA+ + +  +   TA+  A   G  + 
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY-TAVHYAAAYGNRQN 565

Query: 521 ADFLIKAG----ADIELGCS-TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
            + L++       D+E     +PL  A+  GH E +K L  +  N+      G TAL  A
Sbjct: 566 LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625

Query: 576 CENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAARAGHLCTVQFLISKG--ANVNRATA 632
            E G T+  +VL   GA  L  E +   TPL  AA +GH  ++  LI  G  A++     
Sbjct: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685

Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
               T + LA   GH+  V LLL  G+        G T L   A  G  + ++ LLD+  
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745

Query: 693 NVL 695
            VL
Sbjct: 746 FVL 748



 Score =  127 bits (318), Expect = 2e-28
 Identities = 151/566 (26%), Positives = 233/566 (41%), Gaps = 79/566 (13%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  A S G+V  +  LL  G  +    + G + L  A + G Y+ A  L+   A V +  
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486

Query: 269 NKGDITPLMAASSGGY---------------------------LDIVKLLLLHDADVNSQ 301
            KG      AA+S  Y                              ++ LL + AD + +
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546

Query: 302 SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGH--TPLMEAASAGHVEVARVLLD 359
              G TA+ YA A G    +++LL    N  +  E+    +PL  AA  GH E  + L +
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606

Query: 360 HGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHV 418
               ++   ++ + +AL LA  +G  + V  L   GA    K  +   T L  A   GH 
Sbjct: 607 TLVNLDVRDHKGR-TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665

Query: 419 EVARLLLDSG--AQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475
           +   LL+DSG  A +    D++ ++PL LA   GHV+   LL+E+G+  +  +  G T L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725

Query: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------- 528
              A  G E+ +A LL   A +  +  + + T + LA   G + V   L++A        
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASACGHTAVLRTLLQAALSTDPLD 784

Query: 529 ADIELGCSTPLMEASQEGHLELVKYLL--------------------------------- 555
           A ++    +P+  AS  GH + ++ LL                                 
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLG 844

Query: 556 ASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614
           A GA  V++  A G T L  A    +     +LLQ  A++      GRT LM AA  G  
Sbjct: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904

Query: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM--- 671
             V+FL+ +G         N +T + LAC+ GH     ++LA   D        S +   
Sbjct: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964

Query: 672 LIEAAKGGHTNVVSYLLDYPNNVLSV 697
           L  AA+ G  +VV  LL +   VL+V
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAV 990



 Score =  122 bits (307), Expect = 3e-27
 Identities = 102/342 (29%), Positives = 165/342 (48%), Gaps = 36/342 (10%)

Query: 1069 ELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSL 1128
            E V  L+++   I   D++  TPL  AA  G V ++++LL  G ++ A+      TPL  
Sbjct: 22   EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL-TPLHR 80

Query: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
            A +   ++V+ LLLA  A+   R+    TPL +AA+       + L    + +N     +
Sbjct: 81   AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN--VADR 138

Query: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
             G S L  A  +GH+  V LLL+ G+ +N   +  R   L  A F G  EV+ LL+ R A
Sbjct: 139  SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGHLEVLKLLVARGA 197

Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV-------------------- 1288
            ++  + + G   L  AA+ G  EV + LL  GA+++ P                      
Sbjct: 198  DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 257

Query: 1289 ----------PSSRD-TALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
                      P+ +  T L +AA   +   C ELL++ GA ++ ++K+G +PL +A+  G
Sbjct: 258  LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317

Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
             F   Q+L+Q G+++D AD    TPL  A R GH  ++  L+
Sbjct: 318  RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359



 Score =  112 bits (279), Expect = 6e-24
 Identities = 118/415 (28%), Positives = 183/415 (44%), Gaps = 21/415 (5%)

Query: 212  ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
            A  +G   A++ L +   +++    +G + L LA   G  E  +VL A  A+   +  K 
Sbjct: 592  AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 272  DITPLMAASSGGYLDIVKLLLLHD--ADVNS-QSATGNTALTYACAGGFVDIVKVLLNEG 328
              TPL AA++ G+ D + LL+     AD+     A G T L  A   G VD V +LL +G
Sbjct: 652  KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 329  ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGHLDM 387
            +  +  +  G T L   A  G  +    LLDH A +     +FK  + + LA   GH  +
Sbjct: 712  STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR--DFKGRTPIHLASACGHTAV 769

Query: 388  VRFLLEAGADQEHKTDEM----HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
            +R LL+A    +     +    ++ +  A   GH +   LLL+      +  + F +PL 
Sbjct: 770  LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLH 828

Query: 444  LAACGGHVELAALLIER-GANLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
             A          +L+   GA +    D +G TPL  AA   +   + +LL   A +NA T
Sbjct: 829  CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA-T 887

Query: 502  EETQETALTLACCGGFSEVADFLIKAG-ADIEL---GCSTPLMEASQEGHLELVKYLLAS 557
            + T  TAL  A   G +   +FL+  G AD+ +     +T L  A  +GH +    +LA 
Sbjct: 888  DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947

Query: 558  GAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
              +   ++AT +     L  A  NG   V   LL  GA +    E G TP +  A
Sbjct: 948  TQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002



 Score =  103 bits (257), Expect = 2e-21
 Identities = 103/371 (27%), Positives = 163/371 (43%), Gaps = 51/371 (13%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
            +TAL +AC  G + +   L+   A +   + KGFTPL +AA + +  + +E+L++ G D+
Sbjct: 240  NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299

Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
              QS+  K +PL +A   GR     +L+  G+  +  +    TPL +AA  G+  +I  L
Sbjct: 300  NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358

Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS------------------DI 1216
            +  GA+  +R G    + PL LA + G     + LL  G                   DI
Sbjct: 359  MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416

Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
            N      R T L  A   G  E ++LLL   A++  R K G TPL  AA+ G  +    L
Sbjct: 417  NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475

Query: 1277 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1310
            +  GA VN                       P  PSS D        +   K   FC E 
Sbjct: 476  VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535

Query: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV--DAADNRKITPLMSAFRK 1368
            L+  GA   +R+++G T +  A+  G+   ++LL++   +   D      ++PL  A   
Sbjct: 536  LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595

Query: 1369 GHVKVVQYLVK 1379
            GH + ++ L +
Sbjct: 596  GHCEALKTLAE 606



 Score =  102 bits (254), Expect = 5e-21
 Identities = 105/373 (28%), Positives = 154/373 (41%), Gaps = 48/373 (12%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKK---GFTPLILAATAGHVGVVEILLDKGGD 1113
            T L  A A GH + + +LI    + +  D     G TPL+LA   GHV  V +LL+KG  
Sbjct: 654  TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713

Query: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
             +A   R + T L      G ++ +  LL   A    R+    TP+ LA++ G+  +++ 
Sbjct: 714  ADAADLRGR-TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772

Query: 1174 LLNAGAEINSRTGSK--LGISPLMLAAMNGHVPAVKLLLD-------------------- 1211
            LL A    +         G SP+  A+  GH   ++LLL+                    
Sbjct: 773  LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832

Query: 1212 -------------MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGL 1258
                         +G+ I    +    T L  A F      + +LL  +A V     TG 
Sbjct: 833  NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892

Query: 1259 TPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
            T LM AA  G       LL +G AD+    +  +++TAL +A  KGH K C L+I     
Sbjct: 893  TALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHEK-CALMILAETQ 949

Query: 1318 ----IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP-LMSAFRKGHVK 1372
                I+  N     PL +A+  G   VVQ L+  GA V A D    TP L  A  K    
Sbjct: 950  DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVAD 1009

Query: 1373 VVQYLVKEVNQFP 1385
             +  ++  +  FP
Sbjct: 1010 CLALILSTMKPFP 1022



 Score = 95.5 bits (236), Expect = 6e-19
 Identities = 103/395 (26%), Positives = 155/395 (39%), Gaps = 77/395 (19%)

Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
            L LA   GH E +  L      ++ RD KG T L LA   G    VE+L   G     + 
Sbjct: 589  LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648

Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
             + K TPL  A + G  + + LL+  G   +  +V D    TPL LA   G+V+ + +LL
Sbjct: 649  RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708

Query: 1176 NAG-----AEINSRTGSKLGI--------------------------SPLMLAAMNGHVP 1204
              G     A++  RT    G                           +P+ LA+  GH  
Sbjct: 709  EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768

Query: 1205 AVKLLLDMG---SDINAQIETNRNTALTLACFQGRAEVVSLLLDRK-------------- 1247
             ++ LL        ++A ++ +  + +  A + G  + + LLL+                
Sbjct: 769  VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLH 828

Query: 1248 --------------------ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287
                                  V  R   G TPL  AA        R+LL   A+VNA  
Sbjct: 829  CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA-- 886

Query: 1288 VPSSRDTALTIAADKGHYKFCELLIHRG-AHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
               +  TAL  AA+ G     E L++RG A + V ++  NT L LA + GH     +++ 
Sbjct: 887  TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946

Query: 1347 AGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 1378
               D   ++A ++    PL  A R G   VVQ L+
Sbjct: 947  ETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 74/228 (32%), Positives = 116/228 (50%), Gaps = 5/228 (2%)

Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
            +++D  PL  A     V  ++ LL+    IN     +   +PL  AA  G VP ++LLL 
Sbjct: 5    SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62

Query: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
             G+++NA+ +T   T L  A      +V+ LLL   A+V  R K   TPL  AA+    +
Sbjct: 63   SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121

Query: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
                L    + +N      S  +AL  A   GH +   LL+++GA ++V +KK   PL  
Sbjct: 122  CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179

Query: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            A+  GH +V++LLV  GAD+   D +    L +A   G ++VV+YL++
Sbjct: 180  AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 85/273 (31%), Positives = 132/273 (48%), Gaps = 15/273 (5%)

Query: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1177
            T   PL  A      E V  LL++   KE+ NV D    TPL  AA  G V I+++LL +
Sbjct: 7    TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63

Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
            GA +N++    L ++PL  AA + +   + LLL   +D+NA+ +    T L +A      
Sbjct: 64   GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120

Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
            +    L    +++    ++G + L  A   G+ E   +LL+KGA +N           L 
Sbjct: 121  KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178

Query: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
             AA  GH +  +LL+ RGA +  +++KG   L  A+  G  +VV+ L++ GA++D  +  
Sbjct: 179  WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238

Query: 1358 KITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387
              T L  A   G   V   LV     VNQ P+D
Sbjct: 239  GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270



 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)

Query: 209  LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264
            LA AC  G    +R LL    S +         G S +  A   G+ +  ++LL      
Sbjct: 760  LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817

Query: 265  EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322
               GN    TPL  A         ++LL  L    VNS+ A G T L  A     V  ++
Sbjct: 818  YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875

Query: 323  VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
            +LL   A +   +  G T LM AA  G       LL  G    T  +E K +AL LAC K
Sbjct: 876  MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935

Query: 383  GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
            GH      +L    D                                 +N    + + PL
Sbjct: 936  GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965

Query: 443  TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492
             +AA  G   +   L+  GA +  V++EG+TP +  A  +   + +AL+L+
Sbjct: 966  HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)

Query: 264  VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
            V  R  KG  TPL AA+    +  +++LL H A+VN+   TG TAL  A   G    V+ 
Sbjct: 851  VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909

Query: 324  LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380
            LL  G A++   +EN +T L  A S GH + A ++L      G+   +N   +  L +A 
Sbjct: 910  LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
              G   +V+ LL  GA      +E HT  +    +  V     L+ S  +   P D+
Sbjct: 970  RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  168 bits (425), Expect = 7e-41
 Identities = 146/513 (28%), Positives = 231/513 (45%), Gaps = 40/513 (7%)

Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
           D  SL +A  +GD + VR L+ +   VN    E  + L  A   G  E+ ++L+   A V
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT-------------------- 304
             + +K  +TPL  A +    + V++LL H ADVN++                       
Sbjct: 68  NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 305 -------------GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
                        G TAL +A   G  ++VK+LL+ GANI   ++     +  AA  GH+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186

Query: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
           EV ++L+ HGA + T  ++   + L  A   G + +V++LL+ G D        +T L  
Sbjct: 187 EVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245

Query: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA-ALLIERGANLEEVNDE 470
           AC +G   V   L+D GA VN   +   +PL  AA   H  L   LL+  GA++   + +
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305

Query: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
           G TPL   A  G       ++  GA I+ + ++   T L +A   G   + + LI +GAD
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGHELLINTLITSGAD 364

Query: 531 IE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
                +    PL  A+  G  +  + LL+SG ++      G T L  A   G+ +  ++L
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424

Query: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647
           L  GAD   + + GR+PL  AA   +   +  L+  GA+VN         +   A +   
Sbjct: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484

Query: 648 LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680
              +E LL + A+P  R K G   +  +A  GH
Sbjct: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517



 Score =  166 bits (420), Expect = 3e-40
 Identities = 164/584 (28%), Positives = 251/584 (42%), Gaps = 70/584 (11%)

Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
           G  +  + ++  G  ++   + G + L +A   G+  L   L+   A+   RG  G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375

Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
           L  A+  G+ D  + LL    D+++    G T L  A AGG ++ + +LLN GA+    +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391
           + G +PL  AA+  + +    L+  GA +N    +  E   T   Y    D     + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439
           L   A+   +  + + A+  +   GH    +L+            SG  +   +D+    
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           SPL LAA  GH +   +L++   +L+  N  G TPL  AA +GH E V +L+ QGA+I  
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611

Query: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553
           +    + T +  A   G SE    LI     +   DI+ G   TPLM +   GH + V  
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671

Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
           LL  GANV A    G TAL      GH +  D LLQ GA        GRTP+  +A  GH
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731

Query: 614 LCTVQFLISKGANV--NRATA-NNDHTVVSLACAGGHLAVVELLL---------AHGADP 661
           +  +  L+   A++  N ATA N+ +T +  AC  GH   VELLL          +   P
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSP 791

Query: 662 THRL-------------------------KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
            H                             G T L  AA   H   +  LL +   V S
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851

Query: 697 VPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENS 740
           V +T  + L   +++        T+T+ M+V     + T Q+NS
Sbjct: 852 VDSTGKTPLMMAAENGQ------TNTVEMLVSSASAELTLQDNS 889



 Score =  162 bits (409), Expect = 5e-39
 Identities = 160/588 (27%), Positives = 258/588 (43%), Gaps = 64/588 (10%)

Query: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220
           A  K +  P  +     +V CA  EA   L      N + + +    +L  A   G    
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155

Query: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
           V+ LL  G ++N   ++    +  A   G+ E+ ++L++  A V  +  K   TPL AA+
Sbjct: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214

Query: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
           S G + +VK LL    D+N  +A GNT L  AC  G   +V  L++ GA +   NE G T
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274

Query: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
           PL  AA++ H  +   +L+ +GA +N  S + K + L +    G     + ++++GA  +
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333

Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
            +    +T L  A   GH  +   L+ SGA           PL LAA  G  +    L+ 
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393

Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
            G +++  +D G T L  AA  G+ E + LLL  GA+ N + ++   + L  A      +
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452

Query: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGAN-----------VHAT 564
               L+ +GA +    E GC+     A+ +   + ++YLL + AN           VH +
Sbjct: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512

Query: 565 TATGD----------------------------------TALTYACENGHTDVADVLLQA 590
            A G                                   + L  A  +GH    +VL+Q+
Sbjct: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572

Query: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650
             DL+  +  GRTPL  AA  GH+  V  LI++GA++         T +  A   GH   
Sbjct: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632

Query: 651 VELLLAHGADPTHRLK----DGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
           + LL+ + A+P + +     +G T L+ +   GHT+ V  LL+   NV
Sbjct: 633 LRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679



 Score =  155 bits (391), Expect = 6e-37
 Identities = 150/502 (29%), Positives = 218/502 (43%), Gaps = 23/502 (4%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  A S G ++ V+ LLD G  +NE    G + L +AC  G   +   L+   A V  + 
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
            KG  TPL   AAS+ G L  ++LL+ + ADVN +S  G T L      G     + ++ 
Sbjct: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327

Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
            GA I+  ++NG+TPL  AA  GH  +   L+  GA             L LA   G  D
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386

Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
             R LL +G D +   D   T L  A   G++E   LLL++GA  N       SPL  AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446

Query: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505
              + +    L+  GA++ ++++ G TPL  AA    + + +  LL   AN   + ++  
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506

Query: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551
                 A  G              D L++      L  S      +PL  A+  GH + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566

Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAAR 610
           + L+ S  ++    ++G T L  A   GH +  DVL+  GA  L  +    RTP+  AA 
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAAT 626

Query: 611 AGHLCTVQFLISKGANVNRATA--NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668
            GH   ++ LI      N       N  T + L+   GH   V  LL  GA+   + K G
Sbjct: 627 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686

Query: 669 STMLIEAAKGGHTNVVSYLLDY 690
            T L   A  GH   V  LL +
Sbjct: 687 RTALHRGAVTGHEECVDALLQH 708



 Score =  148 bits (373), Expect = 8e-35
 Identities = 103/324 (31%), Positives = 177/324 (54%), Gaps = 8/324 (2%)

Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
            A+  A   GH E+V +L++  A++  +DKK +TPL  AA++G + VV+ LLD G D+  +
Sbjct: 176  AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-E 234

Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI-IKILLN 1176
                 +TPL +AC  G+  VV+ L+  GA    +N   +TPL  AA+  +  + +++L+ 
Sbjct: 235  PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294

Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
             GA++N +  SK G +PL + A++G     + ++  G+ I+ + + N NT L +A   G 
Sbjct: 295  NGADVNMK--SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGH 351

Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
              +++ L+   A+   R   G+ PL  AA  G+++  R LL  G D++ P       T L
Sbjct: 352  ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP--DDFGRTCL 409

Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
              AA  G+ +   LL++ GA  + ++K G +PL  A+   ++  +  LV +GA V+  D 
Sbjct: 410  HAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469

Query: 1357 RKITPL-MSAFRKGHVKVVQYLVK 1379
            R  TPL  +A      K ++YL++
Sbjct: 470  RGCTPLHYAATSDTDGKCLEYLLR 493



 Score =  147 bits (370), Expect = 2e-34
 Identities = 112/352 (31%), Positives = 177/352 (50%), Gaps = 9/352 (2%)

Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
           L++A   G  +  R L+     +N   NE K + L  A Y G  +++  L+ +GA    K
Sbjct: 12  LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
             +  T L  A      E  ++LL   A VN    ++++PL +AA    V+ A  L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
           +N+   +  G T L  AA  GH EMV LLL++GANINA  ++    A+  A   G  EV 
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189

Query: 522 DFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
             L+  GA++   +    TPL  A+  G + +VKYLL  G +++   A G+T L  AC N
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249

Query: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH--LCTVQFLISKGANVNRATANNDH 636
           G   V + L+  GA +  ++E G TPL  AA + H  LC ++ L+  GA+VN   + +  
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC-LELLVGNGADVN-MKSKDGK 307

Query: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
           T + +    G  +  + ++  GA      K+G+T L  AA+ GH  +++ L+
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359



 Score =  146 bits (369), Expect = 2e-34
 Identities = 126/423 (29%), Positives = 192/423 (45%), Gaps = 9/423 (2%)

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
           D   L+ A   G  D V+ L+    DVN Q     T L  A   G  +I+++L+  GA +
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
              +    TPL  A ++   E  +VLL H A +N     + ++ L +A     +     L
Sbjct: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           +   ++         TAL  A   GH E+ +LLL  GA +N         +  AA  GH+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           E+  LL+  GA +   + + YTPL  AA  G   +V  LL  G ++N +      T L +
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245

Query: 512 ACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL-VKYLLASGANVHATTA 566
           AC  G   V + LI  GA +    E G  TPL  A+   H  L ++ L+ +GA+V+  + 
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304

Query: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
            G T L     +G    +  ++Q+GA ++ E + G TPL  AAR GH   +  LI+ GA+
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364

Query: 627 VNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686
             +   +     + LA   G       LL+ G D       G T L  AA GG+   ++ 
Sbjct: 365 TAKRGIHGMFP-LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNL 423

Query: 687 LLD 689
           LL+
Sbjct: 424 LLN 426



 Score =  142 bits (358), Expect = 4e-33
 Identities = 131/447 (29%), Positives = 201/447 (44%), Gaps = 46/447 (10%)

Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
           + D  N+  I+PL  A+  G+   +++L+    D++ ++++G T L  A   G V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601

Query: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379
           L+N+GA+I  +D+     TP+  AA+ GH E  R+L+ +    N    +    ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              GH D V  LL  GA+ + K     TAL    + GH E    LL  GA+  +      
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720

Query: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495
           +P+ L+A  GH+ +   L++  A+++      ++ GYT L  A   GHE  V LLL Q  
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778

Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
            +  +TE    + L  A        A+ LI       LG S                   
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815

Query: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
                V+AT + G T L  A    H +   +LL   A +      G+TPLM AA  G   
Sbjct: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870

Query: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS-----T 670
           TV+ L+S  +       N+ +T + LAC+ GH     L+L    D    L + +     T
Sbjct: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD--RNLINATNAALQT 928

Query: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSV 697
            L  AA+ G T VV  LL    +VL+V
Sbjct: 929 PLHVAARNGLTMVVQELLGKGASVLAV 955



 Score =  141 bits (355), Expect = 9e-33
 Identities = 109/353 (30%), Positives = 163/353 (46%), Gaps = 36/353 (10%)

Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
            +L  A   G  + V  LI +   +  +D +  TPL  AA  G   ++E+L+  G  + A+
Sbjct: 11   SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
              +   TPL  A +   +E V +LL   A+   R+ +  TPL +AA+   V   + L+  
Sbjct: 71   DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129

Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
             + +N     + G + L  AA +GH   VKLLL  G++INA  + +R  A+  A + G  
Sbjct: 130  LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186

Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---- 1293
            EVV LL+   A V  + K   TPL  AAS G   V + LLD G D+N P    +      
Sbjct: 187  EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246

Query: 1294 ---------------------------TALTIAADKGHYKFC-ELLIHRGAHIDVRNKKG 1325
                                       T L  AA   H   C ELL+  GA +++++K G
Sbjct: 247  CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306

Query: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
             TPL + +  G F   Q ++Q+GA +D  D    TPL  A R GH  ++  L+
Sbjct: 307  KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359



 Score =  140 bits (352), Expect = 2e-32
 Identities = 109/348 (31%), Positives = 165/348 (47%), Gaps = 42/348 (12%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L  A   G  E++ +LI   A++  +D K  TPL  A  +     V++LL    D+ A
Sbjct: 43   TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102

Query: 1117 Q--------------------------------SERTKDTPLSLACSGGRQEVVDLLLAR 1144
            +                                S+R   T L  A   G  E+V LLL+R
Sbjct: 103  RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162

Query: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204
            GAN    +  D   +  AA  G++ ++K+L++ GAE+  +   K   +PL  AA +G + 
Sbjct: 163  GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220

Query: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
             VK LLD+G D+N +     NT L +AC+ G+  VV+ L+D  A V  + + G TPL  A
Sbjct: 221  VVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279

Query: 1265 ASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVR 1321
            A+  +  +   +L+  GADVN      S+D  T L + A  G +   + +I  GA ID  
Sbjct: 280  AASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335

Query: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
            +K GNTPL +A+  GH  ++  L+ +GAD        + PL  A   G
Sbjct: 336  DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383



 Score =  134 bits (337), Expect = 1e-30
 Identities = 133/477 (27%), Positives = 205/477 (42%), Gaps = 44/477 (9%)

Query: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201
           ++  L+ L+E +G   LS +D +A   P  L         AL+    +L  +   NS   
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584

Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258
             +D      A   G V  V  L+++G S  V ++  +  + +  A + G+ E  ++L+ 
Sbjct: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638

Query: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
            A   N  D  +    TPLM +   G+ D V  LL   A+V+++   G TAL      G 
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698

Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374
            + V  LL  GA     +  G TP+  +A+ GH+ V   LL   A ++ +   ++    +
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758

Query: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433
           AL  ACY GH   V  LLE    Q+ + +   + L  A ++ +   A +L+D+ GA +  
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817

Query: 434 PADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
             DS   +PL  AA   HVE   LL+   A +  V+  G TPLM AA  G    V +L++
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877

Query: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552
             +      + ++ TAL LAC  G    A  +++   D  L                   
Sbjct: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL------------------- 918

Query: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
                   ++AT A   T L  A  NG T V   LL  GA +    E G TP +  A
Sbjct: 919 --------INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967



 Score =  122 bits (305), Expect = 6e-27
 Identities = 108/394 (27%), Positives = 173/394 (43%), Gaps = 59/394 (14%)

Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
            L LA   GH + + VL+     ++ R+  G TPL LAA  GHV  V++L+++G  I  + 
Sbjct: 554  LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
               K TP+  A + G  E + LL+     +   ++ D    TPL L+   G+ + +  LL
Sbjct: 614  YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673

Query: 1176 NAGAEINSRT-------------------------GSKL------GISPLMLAAMNGHVP 1204
            N GA ++++                          G+K       G +P+ L+A  GH+ 
Sbjct: 674  NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733

Query: 1205 AVKLLLDMGSDINAQIETNRN---TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261
             +  LL   + ++A   T  N   TAL  AC+ G    V LLL+++   +       +PL
Sbjct: 734  VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792

Query: 1262 MEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
              A          +L+D  GA  VNA    S   T L  AA   H +  +LL+   A ++
Sbjct: 793  HCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQ-AGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
              +  G TPL +A+  G  + V++LV  A A++   DN K T L  A  KGH        
Sbjct: 851  SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-------- 902

Query: 1379 KEVNQFPSDIECMRYIATITDKELLKKCHQCVET 1412
                    +   +  +  ITD+ L+   +  ++T
Sbjct: 903  --------ETSALLILEKITDRNLINATNAALQT 928



 Score =  119 bits (297), Expect = 5e-26
 Identities = 110/371 (29%), Positives = 172/371 (46%), Gaps = 51/371 (13%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
            +T L +AC  G + +V+ LI   A +  +++KGFTPL  AA + H  + +E+L+  G D+
Sbjct: 240  NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299

Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
              +S+  K TPL +    GR      ++  GA  +  + +  TPL +AA  G+  +I  L
Sbjct: 300  NMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358

Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
            + +GA+   R     G+ PL LAA++G     + LL  G DI+   +  R T L  A   
Sbjct: 359  ITSGADTAKR--GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAG 415

Query: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV 1288
            G  E ++LLL+  A+   + K G +PL  AA+    +    L+  GA VN        P+
Sbjct: 416  GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475

Query: 1289 ----------------------PSSRD----TALTIAADKGHYKFCELLIHRGAHIDV-- 1320
                                  P  RD     A+  +A  GH + C  LI     +DV  
Sbjct: 476  HYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLM 534

Query: 1321 -----------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
                        N+   +PL LA+  GH   +++LVQ+  D+D  ++   TPL  A  KG
Sbjct: 535  ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594

Query: 1370 HVKVVQYLVKE 1380
            HV+ V  L+ +
Sbjct: 595  HVECVDVLINQ 605



 Score =  117 bits (293), Expect = 1e-25
 Identities = 101/329 (30%), Positives = 150/329 (45%), Gaps = 16/329 (4%)

Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
            +VDI    + N  T L L+   GH + V  L+ + A ++ +DK G T L   A  GH   
Sbjct: 645  AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701

Query: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL----ARGANKEHRNVSDYTPL 1159
            V+ LL  G     +  R + TP+ L+ + G   V+  LL    +  AN    +   YT L
Sbjct: 702  VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760

Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINA 1218
              A   G+   +++LL    E+  +T      SPL  A +N +  A ++L+D +G+ I  
Sbjct: 761  HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817

Query: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
              ++   T L  A F    E + LLL   A V     TG TPLM AA  G      +L+ 
Sbjct: 818  ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876

Query: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH---IDVRNKKGNTPLWLASNG 1335
              A        +S++TAL +A  KGH     L++ +      I+  N    TPL +A+  
Sbjct: 877  SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936

Query: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMS 1364
            G   VVQ L+  GA V A D    TP ++
Sbjct: 937  GLTMVVQELLGKGASVLAVDENGYTPALA 965



 Score =  103 bits (256), Expect = 3e-21
 Identities = 80/260 (30%), Positives = 130/260 (50%), Gaps = 6/260 (2%)

Query: 1120 RTKDTP-LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
            + +D P L  A   G  + V  L+ +  +   ++    TPL  AA  G   II++L+ +G
Sbjct: 5    KLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG 64

Query: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238
            A +N++    L  +PL  A  +    AV++LL   +D+NA+ + N  T L +A      +
Sbjct: 65   ARVNAKDSKWL--TPLHRAVASCSEEAVQVLLKHSADVNAR-DKNWQTPLHIAAANKAVK 121

Query: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
                L+   +NV    + G T L  AA  G+ E+ ++LL +GA++NA      R  A+  
Sbjct: 122  CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHW 179

Query: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
            AA  GH +  +LL+  GA +  ++KK  TPL  A++ G   VV+ L+  G D++  +   
Sbjct: 180  AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239

Query: 1359 ITPLMSAFRKGHVKVVQYLV 1378
             TPL  A   G   VV  L+
Sbjct: 240  NTPLHVACYNGQDVVVNELI 259



 Score = 94.7 bits (234), Expect = 1e-18
 Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 45/321 (14%)

Query: 215 DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
           +G  + V  LL++G +V+   + G + L      G+ E    LL   A    R ++G  T
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-T 721

Query: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSAT----GNTALTYACAGGFVDIVKVLL----- 325
           P+  +++ G++ ++  LL   A +++  AT    G TAL +AC  G    V++LL     
Sbjct: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 781

Query: 326 ------------------NEGAN-----------IEDHNENGHTPLMEAASAGHVEVARV 356
                             NEGA            +   +  G TPL  AA   HVE  ++
Sbjct: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841

Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALMEACMD 415
           LL H A +N+  +  K + L +A   G  + V  L+  A A+   + +  +TAL  AC  
Sbjct: 842 LLSHNAQVNSVDSTGK-TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900

Query: 416 GHVEVARLLLDSGAQ---VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472
           GH   A L+L+       +N    + ++PL +AA  G   +   L+ +GA++  V++ GY
Sbjct: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960

Query: 473 TPLMEAA-REGHEEMVALLLA 492
           TP +  A  +   + +AL+LA
Sbjct: 961 TPALACAPNKDVADCLALILA 981



 Score = 68.9 bits (167), Expect = 6e-11
 Identities = 54/193 (27%), Positives = 87/193 (45%), Gaps = 7/193 (3%)

Query: 1016 QTTE--CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSV 1073
            Q TE    +P  C+    N  +  M        I   T+S   T L  A    H E + +
Sbjct: 782  QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841

Query: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGG 1133
            L++ +A++   D  G TPL++AA  G    VE+L+          + +K+T L LACS G
Sbjct: 842  LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901

Query: 1134 RQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
             +    L+L +  ++   N ++    TPL +AA  G   +++ LL  GA +      + G
Sbjct: 902  HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENG 959

Query: 1191 ISPLMLAAMNGHV 1203
             +P +  A N  V
Sbjct: 960  YTPALACAPNKDV 972



 Score = 43.5 bits (101), Expect = 0.003
 Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 1/166 (0%)

Query: 529 ADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 588
           A ++L     L++A   G  + V+ L+    +V+       T L  A   G  ++ ++L+
Sbjct: 2   AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61

Query: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
            +GA +  +     TPL +A  +     VQ L+   A+VN A   N  T + +A A   +
Sbjct: 62  LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120

Query: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
              E L+   ++     + G T L  AA  GH  +V  LL    N+
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166



 Score = 42.7 bits (99), Expect = 0.005
 Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 9/107 (8%)

Query: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370
            LI +   ++ ++ +  TPL  A+  G  ++++LL+ +GA V+A D++ +TPL  A     
Sbjct: 27   LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86

Query: 1371 VKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
             + VQ L+K   +VN    + +   +IA         K  +C E +V
Sbjct: 87   EEAVQVLLKHSADVNARDKNWQTPLHIAA------ANKAVKCAEALV 127



 Score = 38.9 bits (89), Expect = 0.065
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 5/124 (4%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIAR--DAKIEHRDKKGF-TPLILAATAGHVGVVEILL 1108
            +++ +TAL LAC+ GHE    +++ +  D  + +       TPL +AA  G   VV+ LL
Sbjct: 887  DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946

Query: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168
             KG  + A  E    TP +LAC+  +     L L         + S  + L+  A   Y 
Sbjct: 947  GKGASVLAVDENGY-TP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYT 1004

Query: 1169 NIIK 1172
            N  K
Sbjct: 1005 NTSK 1008


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  167 bits (423), Expect = 1e-40
 Identities = 162/527 (30%), Positives = 232/527 (44%), Gaps = 59/527 (11%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
           L EA   G ++    LL  G   N    +G+S L LA  +      G Y+  ++L A  +
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345

Query: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
             E++                G K   TPL  A+    + IV+LLL H ADV+++   G 
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403

Query: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
             L  AC+ G  ++ ++LL  GA +   +    TPL EAAS   VEV  +LL HGA    
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463

Query: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
           +N H                   EFK  +L  A  +  L  V+  L        +     
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523

Query: 407 TALMEACMDGH---VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
           TAL  A    H    +V  LLL  GA VN     F +PL +AA   H ++  +L + GA 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
           +  ++  G T L  AA  GH +   LLL+ G++ +  + +      T A  G  +E    
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ----GFTAAQMG--NEAVQQ 637

Query: 524 LIKAGADIELG-CSTPLMEASQEGHLELVKYLLASGANVHATTATG--DTALTYACENGH 580
           ++     I        L+EAS+ G LE VK  L S  NV+     G   T L +A     
Sbjct: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNR 696

Query: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
             V + LL  GAD+  + +GG  PL  A   GH    + L+  GA+VN A      T + 
Sbjct: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK-FTPLH 755

Query: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
            A A G   + +LLL HGADPT + +DG+T L +  K G T++   L
Sbjct: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLL 801



 Score =  166 bits (419), Expect = 4e-40
 Identities = 176/565 (31%), Positives = 249/565 (44%), Gaps = 82/565 (14%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGE--SLLCLACSAGYYELAQVLLAMHANV 264
           R L EAC +GDV+ V++L+D   +VN     G   S L  A   G  ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             R + G + PL  A S G+ ++V LLL   AD N++     T L  A   G +D+  VL
Sbjct: 243 HARDD-GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301

Query: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVLLDHGAGI 364
           L  GA+    N +G + L                    +EAA +G+ E    LL     +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNV 360

Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY-------TP-- 474
           LL  GA VN       +PL  AA    VE+ +LL+  GA+   VN  G        TP  
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480

Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
                       L++AARE     V   LA    IN +  ++ ETAL  A         +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539

Query: 520 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
           V + L++ GA++        TPL  A++  H ++++ L   GA ++A    G TAL  A 
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599

Query: 577 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 610
             GH     +LL  G+D                     +  ES   RT      L++A++
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659

Query: 611 AGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
           AG L TV+ L S   NVN       H T +  A     ++VVE LL HGAD   + K G 
Sbjct: 660 AGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718

Query: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
             L  A   GH  V   L+ +  +V
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASV 743



 Score =  150 bits (378), Expect = 2e-35
 Identities = 173/616 (28%), Positives = 253/616 (41%), Gaps = 98/616 (15%)

Query: 149 LLEAAGIGKLSTADGKA---FADPEVLRRLTS---------SVSCALDEAAAALTRMKAE 196
           LL+      +   DGK+    ADP     LT          +     +E   AL      
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360

Query: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
           N H +    +  L  A     V  V+ LL  G  V+   + G   L  ACS G+YE+ ++
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420

Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-------- 308
           LL  H    +  +    TPL  A+S   +++  LLL H AD    +  G +A        
Sbjct: 421 LL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479

Query: 309 ----LTYACAGGFV-------DIVKV---------------------------------- 323
               LTY   G  +       D+ KV                                  
Sbjct: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQ 539

Query: 324 ----LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
               LL +GAN+ + N++  TPL  AA   H +V  VL  HGA +N   +   ++AL  A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRA 598

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
              GHL   R LL  G+D    + +  T    A   G+  V ++L +S     +     +
Sbjct: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSES---TPIRTSDVD 651

Query: 440 SPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
             L  A+  G +E +  L   +  N  ++     TPL  AA      +V  LL  GA+++
Sbjct: 652 YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711

Query: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
           A+ ++     L  AC  G  EVA+ L++ GA +   +L   TPL EA+ +G  E+ K LL
Sbjct: 712 AK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770

Query: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
             GA+       G+T L    E G TD+ D+L             G   L+ AA+ G L 
Sbjct: 771 KHGADPTKKNRDGNTPLDLVKE-GDTDIQDLL------------RGDAALLDAAKKGCLA 817

Query: 616 TVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
            VQ L +   N+N R T   + T + LA    +L V E LL HGAD   + K G   L  
Sbjct: 818 RVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876

Query: 675 AAKGGHTNVVSYLLDY 690
           AA  GH ++ + L+ Y
Sbjct: 877 AASYGHVDIAALLIKY 892



 Score =  138 bits (348), Expect = 6e-32
 Identities = 133/453 (29%), Positives = 207/453 (45%), Gaps = 59/453 (13%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
           SL +A  + D+  V+K L       +  +  E+ L  A ++ + +  QV   LL   ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            ++ NK  +TPL  A+   + D++++L  H A +N+    G TAL  A   G +   ++L
Sbjct: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610

Query: 325 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 358
           L+ G++    +  G T                           L+EA+ AG +E  + L 
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670

Query: 359 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 417
                +N    E + S  L  A     + +V +LL  GAD   K       L  AC  GH
Sbjct: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729

Query: 418 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
            EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL 
Sbjct: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787

Query: 477 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 515
           +  +EG  ++  LL    A                    NIN + T+    T L LA   
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847

Query: 516 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
              EVA++L++ GAD+   + G   PL  A+  GH+++   L+     V+AT     T L
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
             A + G T +  +LL  GAD   +++ G+TPL
Sbjct: 908 HEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940



 Score =  124 bits (311), Expect = 1e-27
 Identities = 114/386 (29%), Positives = 173/386 (44%), Gaps = 46/386 (11%)

Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS--- 1118
            AC+ GH E+VS+L+ + A    RD   +TPL  AA  G + V  +LL  G D   ++   
Sbjct: 256  ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315

Query: 1119 -----------------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
                             E  KD  L  A SG  ++++ LL     N    +    TPL L
Sbjct: 316  KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375

Query: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
            AA    V I+++LL  GA+++++   K G+ PL  A   GH    +LLL  G+ +NA ++
Sbjct: 376  AAGYNRVRIVQLLLQHGADVHAK--DKGGLVPLHNACSYGHYEVTELLLKHGACVNA-MD 432

Query: 1222 TNRNTALTLACFQGRAEVVSLLLDRKA-----NVEHRAKTGLTPLMEAASG-GYAEVGRV 1275
              + T L  A  + R EV SLLL   A     N   ++   + P  E      Y   G  
Sbjct: 433  LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492

Query: 1276 LLDKGADVNAPPV-------------PSSRDTALTIAADKGHYK---FCELLIHRGAHID 1319
            LL    + +   V             P S +TAL  A    H K     ELL+ +GA+++
Sbjct: 493  LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552

Query: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             +NK   TPL +A+   H DV+++L + GA ++A D    T L  A   GH++  + L+ 
Sbjct: 553  EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL- 611

Query: 1380 EVNQFPSDIECMRYIATITDKELLKK 1405
                 PS I    + A     E +++
Sbjct: 612  SYGSDPSIISLQGFTAAQMGNEAVQQ 637



 Score =  113 bits (283), Expect = 2e-24
 Identities = 105/372 (28%), Positives = 165/372 (44%), Gaps = 23/372 (6%)

Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
            L+ A   G V  V+ L+D            K +PL  A   GR++VV+ LL  GAN   R
Sbjct: 186  LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245

Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
            +     PL  A S G+  ++ +LL  GA+ N+R       +PL  AA+ G +    +LL 
Sbjct: 246  DDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQ 303

Query: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
             G+D N +  T+  +AL LA             D  A      +     L+EAA  G  E
Sbjct: 304  HGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEE 349

Query: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
                LL    +VN       + T L +AA     +  +LL+  GA +  ++K G  PL  
Sbjct: 350  KLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408

Query: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIEC- 1390
            A + GH++V +LL++ GA V+A D  + TPL  A  K  V+V   L+      P+ + C 
Sbjct: 409  ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNCH 467

Query: 1391 ----MRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRK 1446
                +    T   +E L    +    +  A++   A+  K  ++ +      +S E +  
Sbjct: 468  GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527

Query: 1447 QALAAKREKRKE 1458
             A+A+   KRK+
Sbjct: 528  CAVASLHPKRKQ 539



 Score =  113 bits (283), Expect = 2e-24
 Identities = 108/378 (28%), Positives = 165/378 (43%), Gaps = 75/378 (19%)

Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD------------ 1109
            AC+ GH E+  +L+   A +   D   FTPL  AA+   V V  +LL             
Sbjct: 409  ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHG 468

Query: 1110 --------------------KGGDI-----EAQSERTKDT--------------PLSLAC 1130
                                KG  +     EA   + K T                +L C
Sbjct: 469  KSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC 528

Query: 1131 SGG-----RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
            +       R++V +LLL +GAN   +N    TPL +AA   + +++++L   GA++N+  
Sbjct: 529  AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL- 587

Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
               LG + L  AA+ GH+   +LLL  GSD +  I     TA  +    G   V  +L +
Sbjct: 588  -DTLGQTALHRAALAGHLQTCRLLLSYGSDPSI-ISLQGFTAAQM----GNEAVQQILSE 641

Query: 1246 ----RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
                R ++V++R       L+EA+  G  E  + L     +VN   +     T L  AA 
Sbjct: 642  STPIRTSDVDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAG 693

Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
                   E L+H GA +  ++K G  PL  A + GH++V +LLV+ GA V+ AD  K TP
Sbjct: 694  YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753

Query: 1362 LMSAFRKGHVKVVQYLVK 1379
            L  A  KG  ++ + L+K
Sbjct: 754  LHEAAAKGKYEICKLLLK 771



 Score =  112 bits (280), Expect = 5e-24
 Identities = 113/373 (30%), Positives = 171/373 (45%), Gaps = 41/373 (10%)

Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
            PS       E   D  L  A +G  E+L+++L   +      D +  TPL LAA    V 
Sbjct: 324  PSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVR 383

Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
            +V++LL  G D+ A+ ++    PL  ACS G  EV +LLL  GA     ++  +TPL  A
Sbjct: 384  IVQLLLQHGADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442

Query: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
            AS   V +  +LL+ GA+   +N    S + ++P                L+ AA    +
Sbjct: 443  ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502

Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLA---CFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
              VK  L +   IN +   +  TAL  A       R +V  LLL + ANV  + K  +TP
Sbjct: 503  AKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561

Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
            L  AA   + +V  VL   GA +NA  + +   TAL  AA  GH + C LL+  G+   +
Sbjct: 562  LHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619

Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQA----GADVDAADNRKITPLMSAFRKGHVKVVQY 1376
             + +G T    A+  G+  V Q+L ++     +DVD         L+ A + G ++ V+ 
Sbjct: 620  ISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQ 668

Query: 1377 LVKEVNQFPSDIE 1389
            L    N    D+E
Sbjct: 669  LCSSQNVNCRDLE 681



 Score =  112 bits (280), Expect = 5e-24
 Identities = 97/297 (32%), Positives = 136/297 (45%), Gaps = 23/297 (7%)

Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            E  H T L  A       +V  L+   A +  +DK G  PL  A + GH  V E+L+  G
Sbjct: 681  EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              +   ++  K TPL  A + G+ E+  LLL  GA+   +N    TPL L   G     I
Sbjct: 741  ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTL 1230
            + LL              G + L+ AA  G +  V+ L     +IN +    RN T L L
Sbjct: 798  QDLLR-------------GDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHL 843

Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
            A      EV   LL+  A+V  + K GL PL  AAS G+ ++  +L+     VNA     
Sbjct: 844  AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901

Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
               T L  AA KG  + C LL+  GA   ++N++G TPL LA+     D+  LL+ A
Sbjct: 902  WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955



 Score =  112 bits (279), Expect = 6e-24
 Identities = 104/314 (33%), Positives = 153/314 (48%), Gaps = 25/314 (7%)

Query: 220 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG-DITPLMA 278
           AV+++L E   +   T + +  L  A  AG  E  + L +   NV  R  +G   TPL  
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690

Query: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
           A+    + +V+ LL H ADV+++   G   L  AC+ G  ++ ++L+  GA++   +   
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750

Query: 339 HTPLMEAASAGHVEVARVLLDHGAGI-------NTHSNEFKE------------SALTLA 379
            TPL EAA+ G  E+ ++LL HGA         NT  +  KE            +AL  A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810

Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
             KG L  V+ L          T   + T L  A    ++EVA  LL+ GA VN      
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870

Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
             PL  AA  GHV++AALLI+    +   +   +TPL EAA++G  ++ ALLLA GA+  
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930

Query: 499 AQTEETQETALTLA 512
            + +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943



 Score =  109 bits (272), Expect = 4e-23
 Identities = 113/354 (31%), Positives = 162/354 (45%), Gaps = 34/354 (9%)

Query: 1004 STRVPTGSNSSSQTTE----CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
            S+  PT S+SSS ++       +PE+     S+ A        P   + A + +  +  L
Sbjct: 131  SSSSPTSSSSSSPSSPGSSLAESPEAAG--VSSTAPLGPGAAGPGTGVPAVSGALRE--L 186

Query: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
              AC  G    V  L+   A +  +D  G   +PL  AA  G   VVE LL  G ++ A+
Sbjct: 187  LEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245

Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
             +     PL  ACS G  EVV LLL +GA+   R+  +YTPL  AA  G +++  +LL  
Sbjct: 246  DDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304

Query: 1178 GAEINSR-TGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
            GA+ N R T  K  +                   L+ AA +G+   +  LL    ++N  
Sbjct: 305  GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVNCH 363

Query: 1220 IETNR-NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
                R +T L LA    R  +V LLL   A+V  + K GL PL  A S G+ EV  +LL 
Sbjct: 364  ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423

Query: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
             GA VNA  +   + T L  AA K   + C LL+  GA   + N  G + + +A
Sbjct: 424  HGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score =  108 bits (270), Expect = 7e-23
 Identities = 101/376 (26%), Positives = 162/376 (43%), Gaps = 54/376 (14%)

Query: 1052 ESNHD--TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
            E N D  T L +A    H +++ VL    AK+   D  G T L  AA AGH+    +LL 
Sbjct: 553  EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612

Query: 1110 KGGD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVDLLLA 1143
             G D                        E+   RT D     L  + +G  + V  L  +
Sbjct: 613  YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672

Query: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHV 1203
            +  N         TPL  AA    V++++ LL+ GA+++++   K G+ PL  A   GH 
Sbjct: 673  QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730

Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-- 1261
               +LL+  G+ +N   +  + T L  A  +G+ E+  LLL   A+   + + G TPL  
Sbjct: 731  EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789

Query: 1262 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
                              ++AA  G  A V ++   +  ++N         T L +AA  
Sbjct: 790  VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847

Query: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
             + +  E L+  GA ++ ++K G  PL  A++ GH D+  LL++    V+A D    TPL
Sbjct: 848  NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907

Query: 1363 MSAFRKGHVKVVQYLV 1378
              A +KG  ++   L+
Sbjct: 908  HEAAQKGRTQLCALLL 923



 Score =  105 bits (263), Expect = 4e-22
 Identities = 105/383 (27%), Positives = 161/383 (42%), Gaps = 69/383 (18%)

Query: 1054 NHDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            +H+TAL  A A  H   +++  +L+ + A +  ++K   TPL +AA   H  V+E+L   
Sbjct: 521  SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
            G  + A  +    T L  A   G  +   LLL+ G++    ++  +T    AA  G   +
Sbjct: 581  GAKMNAL-DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAV 635

Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
             +IL  +     S    +L     + A+  G +  VK L    +     +E   +T L  
Sbjct: 636  QQILSESTPIRTSDVDYRL-----LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690

Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
            A    R  VV  LL   A+V  + K GL PL  A S G+ EV  +L+  GA VN   +  
Sbjct: 691  AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADL-- 748

Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRN---------------------------- 1322
             + T L  AA KG Y+ C+LL+  GA    +N                            
Sbjct: 749  WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALL 808

Query: 1323 ---KKG-----------------------NTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
               KKG                       +TPL LA+   + +V + L++ GADV+A D 
Sbjct: 809  DAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDK 868

Query: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379
              + PL +A   GHV +   L+K
Sbjct: 869  GGLIPLHNAASYGHVDIAALLIK 891



 Score = 94.7 bits (234), Expect = 1e-18
 Identities = 100/313 (31%), Positives = 131/313 (41%), Gaps = 23/313 (7%)

Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
            S+ D  L  A   G  E V  L +    +  RD +G   TPL  AA    V VVE LL  
Sbjct: 648  SDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
            G D+ A+ ++    PL  ACS G  EV +LL+  GA+    ++  +TPL  AA+ G   I
Sbjct: 707  GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765

Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
             K+LL  GA+   +               +G+ P   L L    D + Q     + AL  
Sbjct: 766  CKLLLKHGADPTKKN-------------RDGNTP---LDLVKEGDTDIQDLLRGDAALLD 809

Query: 1231 ACFQG-RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
            A  +G  A V  L      N         TPL  AA     EV   LL+ GADVNA    
Sbjct: 810  AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869

Query: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
                  L  AA  GH     LLI     ++  +K   TPL  A+  G   +  LL+  GA
Sbjct: 870  GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927

Query: 1350 DVDAADNRKITPL 1362
            D    +    TPL
Sbjct: 928  DPTMKNQEGQTPL 940



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 82/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)

Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
            E   VS   PL   A+G            G  + + +G+   +  L+ A  NG V  VK 
Sbjct: 155  EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200

Query: 1209 LLDMGSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267
            L+D  +++NA+    R ++ L  A   GR +VV  LL   ANV  R   GL PL  A S 
Sbjct: 201  LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259

Query: 1268 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
            G+AEV  +LL +GAD      P++RD    T L  AA KG    C +L+  GA  ++RN 
Sbjct: 260  GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313

Query: 1324 KGNTPLWLAS---------------------NGGHFDVVQLLVQAGADVDAADNRKITPL 1362
             G + L LA                      +G    ++ LL     +  A+D RK TPL
Sbjct: 314  DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373

Query: 1363 MSAFRKGHVKVVQYLVK 1379
              A     V++VQ L++
Sbjct: 374  HLAAGYNRVRIVQLLLQ 390



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 1/114 (0%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T+  + T L LA    + E+   L+   A +  +DK G  PL  AA+ GHV +  +L+  
Sbjct: 833  TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
               + A +++   TPL  A   GR ++  LLLA GA+   +N    TPL LA +
Sbjct: 893  NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 42.4 bits (98), Expect = 0.006
 Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A    ++     LL+ G  VN   + G   L  A S G+ ++A +L+  +  V +  +K 
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
             TPL  A+  G   +  LLL H AD   ++  G T L  A A    D ++ LL
Sbjct: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 32/90 (35%), Positives = 41/90 (45%), Gaps = 2/90 (2%)

Query: 600 GGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHG 658
           G    L++A R G +  V+ L+   ANVN +  A    + +  A   G   VVE LL  G
Sbjct: 181 GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239

Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
           A+   R   G   L  A   GH  VVS LL
Sbjct: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLL 269



 Score = 32.7 bits (73), Expect = 4.7
 Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 22/143 (15%)

Query: 1984 SSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMA---- 2039
            S+ P     P++ G AP T   + T+             A+P         D+P +    
Sbjct: 25   SAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPV 84

Query: 2040 ----------NLCT-------PSSTANSCSSSASNTPGAPETH-PSSSPTPTSSNTQEEA 2081
                       +CT       P+ + +S +  A N  G+   + PSSS +PTSS++   +
Sbjct: 85   DGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPS 144

Query: 2082 QPSSVSDLSPMSMPFASNSEPAP 2104
             P S    SP +   +S +   P
Sbjct: 145  SPGSSLAESPEAAGVSSTAPLGP 167



 Score = 32.3 bits (72), Expect = 6.1
 Identities = 35/164 (21%), Positives = 59/164 (35%), Gaps = 26/164 (15%)

Query: 1479 PKENSELPEDEDEEENDEDVEQEVPIEPPS-ATTTTTIGISATSATFTNVFGKKRANVVT 1537
            P+    LPE +   +  +      P++  S  +TT+TI   A +     V     A V  
Sbjct: 59   PRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAP 118

Query: 1538 TPSTNRKNKKNKTKETPPTAHLILPEQ-HMSLAQQKADKNKINGEPRGGGAGG------- 1589
             P+ +  N    +  +P ++    P     SLA+        +  P G GA G       
Sbjct: 119  NPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPA 178

Query: 1590 -------------NSDSDN----LDSTDCNSESSSGGKSQELNF 1616
                         N D       +D+ + N++  +G KS  L+F
Sbjct: 179  VSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHF 222


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  164 bits (416), Expect = 8e-40
 Identities = 128/395 (32%), Positives = 196/395 (49%), Gaps = 54/395 (13%)

Query: 285  LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
            + + +LL+L  A++N ++   N A  L      G+ ++V +LL  GAN++  +E+G TPL
Sbjct: 863  IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922

Query: 343  MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
              AA+AG++ +  +L    A ++ H ++  + AL  A  +GHL++V+FL++     AG  
Sbjct: 923  GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981

Query: 398  QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
            Q    K+  +  AL+ A   G+ E+   LLD           AQ+N   DS   E+ LT 
Sbjct: 982  QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040

Query: 445  AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
            AA  G +E+  LL+E+GA + + N  G  PL    R+GH ++V LLL  GA++N   ++ 
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100

Query: 505  QETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHAT 564
            +                               TPLM A+ EGHL  V +LLA GA++   
Sbjct: 1101 R-------------------------------TPLMMAASEGHLGTVDFLLAQGASIALM 1129

Query: 565  TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
               G TAL++AC  GH  V   L+  GA  +H  + GRTPL  AA  G    VQFL+  G
Sbjct: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189

Query: 625  ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
            A +     +     +  A    + +VV  LL  GA
Sbjct: 1190 AMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223



 Score =  148 bits (373), Expect = 8e-35
 Identities = 106/332 (31%), Positives = 167/332 (50%), Gaps = 24/332 (7%)

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 437
            Y  ++ + R L+  GA+  ++T+ ++ A +  C+  H+   E+  LLL+ GA V+  ++S
Sbjct: 859  YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917

Query: 438  FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
              +PL  AA  G++ +  LL ++ A ++ ++  G   L+ AA  GH E+V  L+     +
Sbjct: 918  GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977

Query: 498  NAQTE------ETQETALTLACCGGFSEVADFLI----KAGADIE---------LGCSTP 538
              Q +         + AL  A   G++E+  +L+    K   ++E         L   T 
Sbjct: 978  AGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA 1037

Query: 539  LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
            L  A+  G LE+ + LL  GA V      G   L      GH  + D+LL  GAD+    
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097

Query: 599  EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
            + GRTPLM AA  GHL TV FL+++GA++         T +S AC  GHL+VV  L+ +G
Sbjct: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156

Query: 659  ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
            A   H  K+G T L  AA  G   VV +L+D+
Sbjct: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188



 Score =  144 bits (364), Expect = 8e-34
 Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            ++   R L+  G ++N  TE      +LC+    GY E+  +LL   ANV D  ++  +T
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 327
            PL  A++ GYL IV LL    A V+     G  AL +A   G +++VK L+        +
Sbjct: 921  PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980

Query: 328  GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 378
               +   +      L+ AAS G+ E+   LLD           A IN+  + + E+ALT 
Sbjct: 981  QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040

Query: 379  ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
            A  +G L++ R LLE GA            L      GH ++  LLL  GA VNM     
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100

Query: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
             +PL +AA  GH+     L+ +GA++  ++ EG T L  A  +GH  +V  L+  GA  +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160

Query: 499  AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 555
               ++   T L LA   G +EV  FL+  GA IE        PL  A    +  +V  LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219

Query: 556  ASGANVHATT 565
              GA +   T
Sbjct: 1220 KKGAKIGPAT 1229



 Score =  132 bits (333), Expect = 3e-30
 Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G +V+  +E G + L  A +AGY  +  +L    A V+     G    
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L+AA+S GY +IV  LL    
Sbjct: 956  VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015

Query: 293  -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
                 +  A +NS  S  G TALT A   G +++ ++LL +GA +   N  G  PL    
Sbjct: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075

Query: 347  SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
              GH ++  +LL HGA +N    + + + L +A  +GHL  V FLL  GA       E  
Sbjct: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134

Query: 407  TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
            TAL  AC+ GH+ V R L+D+GA  +    +  +PL LAA  G  E+   L++ GA +E 
Sbjct: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194

Query: 467  VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
            V+  G  PL  A    +  +V  LL +GA I   T    T +  + +       E  D  
Sbjct: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254

Query: 525  IKAG 528
             K G
Sbjct: 1255 YKKG 1258



 Score =  122 bits (305), Expect = 6e-27
 Identities = 103/322 (31%), Positives = 152/322 (47%), Gaps = 19/322 (5%)

Query: 1073 VLIARDAKIEHRDKKGFTPLILAATA--GHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
            +LI   A I +R +      IL   +  G+  +V +LL+ G +++A SE    TPL  A 
Sbjct: 868  LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGL-TPLGYAA 926

Query: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-----AGAEINSRT 1185
            + G   +V LL  + A  +H + +    L  AA  G++ ++K L+      AG +     
Sbjct: 927  AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFK 986

Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR---------NTALTLACFQGR 1236
             S      L+ AA  G+   V  LLD+      ++E  +          TALT A  +G+
Sbjct: 987  KSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046

Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
             EV  LLL++ A V    + G  PL      G+ ++  +LL  GADVN         T L
Sbjct: 1047 LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM--ADKQGRTPL 1104

Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
             +AA +GH    + L+ +GA I + +K+G T L  A   GH  VV+ LV  GA  D AD 
Sbjct: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164

Query: 1357 RKITPLMSAFRKGHVKVVQYLV 1378
               TPL  A   G  +VVQ+LV
Sbjct: 1165 NGRTPLDLAAFYGDAEVVQFLV 1186



 Score =  120 bits (302), Expect = 1e-26
 Identities = 94/296 (31%), Positives = 145/296 (48%), Gaps = 21/296 (7%)

Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
            ++ V  +L+  G +I  ++E   + P+    S  G  E+V LLL  GAN +  + S  TP
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921

Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
            L  AA+ GY++I+ +L    A+++     K G   L+ AA+ GH+  VK L+     +  
Sbjct: 922  LGYAAAAGYLSIVVLLCKKRAKVDHL--DKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 979

Query: 1219 QIET------NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT----------GLTPLM 1262
            Q +           AL  A   G  E+VS LLD     E   +           G T L 
Sbjct: 980  QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALT 1039

Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
             AA  G  EV R+LL++GA V  P    +     T+   +GH++  +LL+  GA +++ +
Sbjct: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR--QGHWQIVDLLLTHGADVNMAD 1097

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
            K+G TPL +A++ GH   V  L+  GA +   D   +T L  A  KGH+ VV+ LV
Sbjct: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153



 Score =  117 bits (294), Expect = 1e-25
 Identities = 109/335 (32%), Positives = 157/335 (46%), Gaps = 29/335 (8%)

Query: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
            G+ E+V++L+   A ++   + G TPL  AA AG++ +V +L  K   ++   ++     
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCA 954

Query: 1126 LSLACSGGRQEVVDLLLA---------RGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
            L  A   G  EVV  L+          +G  K+   +     L  AAS GY  I+  LL+
Sbjct: 955  LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLD 1012

Query: 1177 AG---------AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
                       A+INS   S  G + L  AA  G +   +LLL+ G+   A  + NR  A
Sbjct: 1013 LPEKDEEEVERAQINS-FDSLWGETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGA 1068

Query: 1228 LTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
            + L     QG  ++V LLL   A+V    K G TPLM AAS G+      LL +GA +  
Sbjct: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128

Query: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
              +     TAL+ A  KGH      L+  GA  D  +K G TPL LA+  G  +VVQ LV
Sbjct: 1129 --MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1186

Query: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
              GA ++  D   + PL  A    +  VV  L+K+
Sbjct: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221



 Score =  115 bits (288), Expect = 5e-25
 Identities = 140/526 (26%), Positives = 214/526 (40%), Gaps = 104/526 (19%)

Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
            ++DA +ES   T L  A A G+  +V +L  + AK++H DK G   L+ AA  GH+ VV+
Sbjct: 910  NVDASSESGL-TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 968

Query: 1106 I----------------------------------------LLDKGGDIEAQSERTK--- 1122
                                                     LLD     E + ER +   
Sbjct: 969  FLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS 1028

Query: 1123 ------DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
                  +T L+ A   G+ EV  LLL +GA     N     PL      G+  I+ +LL 
Sbjct: 1029 FDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT 1088

Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
             GA++N     K G +PLM+AA  GH+  V  LL  G+ I A ++    TAL+ AC +G 
Sbjct: 1089 HGADVN--MADKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGH 1145

Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
              VV  L+D  A  +H  K G TPL  AA  G AEV + L+D GA +    V  S    L
Sbjct: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE--HVDYSGMRPL 1203

Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
              A    +      L+ +GA I           W  +      ++ LL +   + D    
Sbjct: 1204 DRAVGCRNTSVVVTLLKKGAKI-------GPATWAMATSKPDIMIILLSKLMEEGD---- 1252

Query: 1357 RKITPLMSAFRKGHVKVV----QYLVKEVNQ--FPSDIECMRYIATITDKELLKKCHQCV 1410
                     ++KG VK      QY +K+  +  F  D++  R +       LL    +C 
Sbjct: 1253 -------MFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKV----SLLLNLSRCR 1301

Query: 1411 ETIVKAKDQQAAEANKNASILLKELDLE------KSREESRKQALAAK------------ 1452
                K  D   AE     ++ LK    E      +++  SR+ A A +            
Sbjct: 1302 R---KMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1358

Query: 1453 REKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDV 1498
            RE ++   + ++E ++ +Q +     P+   +LPE+ + E   ED+
Sbjct: 1359 REIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDI 1404



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 67/243 (27%), Positives = 104/243 (42%), Gaps = 28/243 (11%)

Query: 472  YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-LTLACCGGFSEVADFLIKAGAD 530
            YTP ++ +R        LL+  GANIN +TE       L +    G++E+   L++ GA+
Sbjct: 859  YTPNIKVSR--------LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN 910

Query: 531  IELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
            ++       TPL  A+  G+L +V  L    A V      G  AL +A   GH +V   L
Sbjct: 911  VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970

Query: 588  LQAGADLEHESEGG-------RTPLMKAARAGHLCTVQFLIS----KGANVNRATANN-- 634
            +Q    +  + +G        +  L+ AA  G+   V +L+         V RA  N+  
Sbjct: 971  IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFD 1030

Query: 635  ---DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
                 T ++ A   G L V  LLL  GA      + G+  L    + GH  +V  LL + 
Sbjct: 1031 SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1090

Query: 692  NNV 694
             +V
Sbjct: 1091 ADV 1093



 Score = 36.6 bits (83), Expect = 0.32
 Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)

Query: 208  SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
            +L+ AC  G ++ VR L+D G + +   + G + L LA   G  E+ Q L+   A +E  
Sbjct: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195

Query: 268  GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
               G + PL  A       +V  LL   A +           T+A A    DI+ +LL++
Sbjct: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246



 Score = 34.7 bits (78), Expect = 1.2
 Identities = 46/179 (25%), Positives = 71/179 (39%), Gaps = 15/179 (8%)

Query: 1972 PATVISSVTSTCSSLPSVSSAPITS---GQAPTTFLPASTSQAQLSSQKMESFS-AVPPT 2027
            P+  +  + S  SS P   SA I+S   G        +S+S    + Q  +S S A+ PT
Sbjct: 1433 PSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPT 1492

Query: 2028 KEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVS 2087
             +  ++  +P     +P+    S   S     G  + +PS  P+P     Q  A P + S
Sbjct: 1493 HQ--NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAES 1550

Query: 2088 -------DLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQP 2139
                     SP+     ++    P    SP    A  Q    +PQL V  P+   R+QP
Sbjct: 1551 MSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMA--QRPYQMPQLPVAVPQQGLRLQP 1607


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  162 bits (409), Expect = 5e-39
 Identities = 158/568 (27%), Positives = 258/568 (45%), Gaps = 32/568 (5%)

Query: 156 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-KAENSHNAGQVDTRSLAEAC 213
           G+     G  + D P+       S+    + +A  L    K +       +DT  L  A 
Sbjct: 12  GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71

Query: 214 SDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           ++G +  + K+  +     ++E  + G + L  A      E  + LL+  AN   R N  
Sbjct: 72  AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR-NFN 130

Query: 272 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
            + PL  A  G   +++K+LL H   DVN +   GNTA+  AC     + +++LL +GA 
Sbjct: 131 MMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190

Query: 331 IEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINTH---SNEFKESALTLACYKG 383
               N+ G  P+ +AA +G  E   ++L    +HG     H    N  K + L LA   G
Sbjct: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250

Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 439
            L+M++  L+ GA  +       TA+  A   G  E+ +L++ S +     VN      E
Sbjct: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310

Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
           + L  A+   H ELA  LI  GA++ +++ EG +PL+ A       +V LLL++GA ++ 
Sbjct: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370

Query: 500 QTEETQETA-LTLACCGGFSEVADFLIKAGADIEL-------GCSTPLMEASQEGHLELV 551
           +    +    LT+    G   +    ++     EL       GC TPL  A ++G    V
Sbjct: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429

Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 608
             LL    ++H+ +    + L +A   G  +    LLQ  +D    +EG   G TPL  A
Sbjct: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489

Query: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL-KD 667
           A+ GH   VQ L+ KGA     + +N  T +  A  GG+   ++++L      T RL +D
Sbjct: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547

Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVL 695
           G+T L  AA+ GH   V+ LL +  +++
Sbjct: 548 GNTALHFAAREGHAKAVALLLSHNADIV 575



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 101/413 (24%), Positives = 180/413 (43%), Gaps = 37/413 (8%)

Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
            I +V   +  G+N + +    + P   +    N     +   + ++D++   E N +TA+
Sbjct: 111  IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAV 169

Query: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
             +AC   + E + +L+ + AK    +K G  P+  AA +G    +EI+L + G+    S 
Sbjct: 170  IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIIL-RFGEEHGYSR 228

Query: 1120 RT--------KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
            +         K TPL LA   G  E++ + L  GA  +       T +  AA+ G   I+
Sbjct: 229  QLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIV 288

Query: 1172 KILLNAGAEINSRTGSKLGISPLML--AAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
            K+++++ +       +  G    ML  A++  H      L+ +G+DIN +I++   + L 
Sbjct: 289  KLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADIN-KIDSEGRSPLI 347

Query: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA------------EVGRVLL 1277
            LA       +V+LLL + A V+ +   G   L       Y             ++  +++
Sbjct: 348  LATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVM 407

Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
            D+  D   P         L  A  +G       L+     I  ++K   +PL  A++ G 
Sbjct: 408  DEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR 458

Query: 1338 FDVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD 1387
             +  Q L+Q  +D   ++  D   +TPL  A + GH KVVQ L+K+   F SD
Sbjct: 459  INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSD 511



 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 96/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)

Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
            SVDI   T+  H+T L  A    H EL   LI+  A I   D +G +PLILA  +    +
Sbjct: 298  SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357

Query: 1104 VEILLDKGGDIEAQS-------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
            V +LL KG  ++ +          T   P  L     R E + +   +    +  N    
Sbjct: 358  VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414

Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
            TPL  A   G    +  LL     I+S++  K   SPL  AA  G +   + LL   SD 
Sbjct: 415  TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472

Query: 1217 NAQIETNRN--TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
                E + +  T L LA   G  +VV LLL +K  +      G T L  A+ GGY +  +
Sbjct: 473  RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531

Query: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
            V+LD         +    +TAL  AA +GH K   LL+   A I V NK+  + L LA +
Sbjct: 532  VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589

Query: 1335 GGHFDVVQLLVQA 1347
                +VV  ++++
Sbjct: 590  NKRKEVVLTIIRS 602



 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 44/322 (13%)

Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
            S+++    +   +T L  A      E V  L++R A    R+     PL +A    +  V
Sbjct: 87   SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146

Query: 1104 VEILLD-KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
            +++LL+ +  D+  + E   +T + +AC+    E + +LL +GA     N     P+  A
Sbjct: 147  MKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205

Query: 1163 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
            A  G    ++I+L  G E        IN     K   +PL LA  NG +  +K+ LD G+
Sbjct: 206  AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGK--ATPLHLAVQNGDLEMIKMCLDNGA 263

Query: 1215 DINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
             I+  +E  R TA+  A  QG  E+V L++         + +G   ++    G       
Sbjct: 264  QID-PVEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDG------- 307

Query: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
                              +T L  A+   H++  + LI  GA I+  + +G +PL LA+ 
Sbjct: 308  ----------------CHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351

Query: 1335 GGHFDVVQLLVQAGADVDAADN 1356
               +++V LL+  GA VD  DN
Sbjct: 352  SASWNIVNLLLSKGAQVDIKDN 373



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +GD+  ++  LD G  ++   +   + +  A + G  E+ +++++ ++   D  N  
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305

Query: 272 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
           D    T L  AS   + ++   L+   AD+N   + G + L  A A    +IV +LL++G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365

Query: 329 ANIE--------------------------------------DHNENGHTPLMEAASAGH 350
           A ++                                      D + +G TPL  A   G 
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425

Query: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 407
                 LL     I++ S + K+S L  A   G ++  + LL+  +D     + ++H  T
Sbjct: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484

Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 466
            L  A  +GH +V +LLL  GA      + + + L  A+ GG+ +   ++++      + 
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543

Query: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
           ++++G T L  AAREGH + VALLL+  A+I    ++     L L
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 62/256 (24%), Positives = 113/256 (44%), Gaps = 33/256 (12%)

Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKILLNAGAEINS 1183
            L  A + G+ E+++ +    + +    + DY  TPL  A     +  +K LL+ GA  N 
Sbjct: 67   LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRNTALTLACFQGRAEVVSL 1242
            R  + +  +PL +A    +   +K+LL+  + D+N + E N NTA+ +AC    +E + +
Sbjct: 127  RNFNMM--APLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQI 183

Query: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
            LL + A      K G  P+ +AA  G  E   ++L  G +                    
Sbjct: 184  LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHG------------------ 225

Query: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
                       R  HI+  N    TPL LA   G  +++++ +  GA +D  +  + T +
Sbjct: 226  ---------YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276

Query: 1363 MSAFRKGHVKVVQYLV 1378
              A  +G  ++V+ ++
Sbjct: 277  HFAATQGATEIVKLMI 292



 Score = 39.3 bits (90), Expect = 0.050
 Identities = 40/187 (21%), Positives = 74/187 (39%), Gaps = 35/187 (18%)

Query: 1194 LMLAAMNGHVPAV-KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252
            L  AA  G +  + K+  D   ++  +++   NT L  A  + + E V  LL R AN   
Sbjct: 67   LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126

Query: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
            R    + PL  A  G   EV +VLL+                                  
Sbjct: 127  RNFNMMAPLHIAVQGMNNEVMKVLLE---------------------------------- 152

Query: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
            HR   +++  + GNT + +A    + + +Q+L++ GA    ++     P+  A   G  +
Sbjct: 153  HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 212

Query: 1373 VVQYLVK 1379
             ++ +++
Sbjct: 213  CMEIILR 219


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  159 bits (403), Expect = 3e-38
 Identities = 164/560 (29%), Positives = 242/560 (43%), Gaps = 80/560 (14%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
           R L EAC +GDV  V++L+     VN     G     L  +AG+   ++ + LL   ANV
Sbjct: 26  RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
           + R + G + PL  A S G+ ++V LLL H AD N++     T L  A   G +D+  VL
Sbjct: 85  QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143

Query: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
           L  GA     N +G T                     L+E+A +G+ E    LL     +
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202

Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
           N H+++ ++S  L LA     + +V+ LL+ GAD   K       L  AC  GH EV  L
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262

Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
           L+  GA VN       +PL  AA    VE+ +LL+  GA+   +N       D   TP  
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322

Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
                       L++AARE     +   L+    +N +  +T ETAL  A    +    +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381

Query: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
           + + L++ GA+I        TPL  AS++ H ++V+ ++   A V+A    G T+L  A 
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 577 ENGHTDVADVLLQAGADLEHESEGGRT--------------------------PLMKAAR 610
             GH     +LL  G D    S  G T                           L++AA+
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK 501

Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
           AG + TV+ L +  +   R       T +  A     ++VVE LL HGAD   + K G  
Sbjct: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561

Query: 671 MLIEAAKGGHTNVVSYLLDY 690
            L  A   GH  V   L+ +
Sbjct: 562 PLHNACSYGHYEVAELLVKH 581



 Score =  148 bits (373), Expect = 8e-35
 Identities = 142/495 (28%), Positives = 224/495 (45%), Gaps = 76/495 (15%)

Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
           SL +A  + DV  ++K L       +H +  E+ L  A ++ Y    ++ ++LL   AN+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
            ++  K  +TPL  AS   + D+V++++ H+A VN+    G T+L  A   G +   ++L
Sbjct: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
           L+ G +           ++  NEN    L E  S G+ E  R LL+              
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512

Query: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
               +N    E ++S  L  A     + +V +LL+ GAD   K       L  AC  GH 
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572

Query: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
           EVA LL+  GA VN+ AD ++ +PL  AA  G  E+  LL++ GA+  + N +G TPL +
Sbjct: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630

Query: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
             ++G  ++  LL    A ++A  +          C     +++        D +   ST
Sbjct: 631 LVKDGDTDIQDLLRGDAALLDAAKK---------GCLARVKKLSSPDNVNCRDTQGRHST 681

Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
           PL  A+   +LE+ +YLL  GA+V+A    G   L  A   GH DVA +L++  A +   
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741

Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
            +   TPL +AA+ G                           +  CA        LLLAH
Sbjct: 742 DKWAFTPLHEAAQKGR--------------------------TQLCA--------LLLAH 767

Query: 658 GADPTHRLKDGSTML 672
           GADPT + ++G T L
Sbjct: 768 GADPTLKNQEGQTPL 782



 Score =  146 bits (369), Expect = 2e-34
 Identities = 170/580 (29%), Positives = 241/580 (41%), Gaps = 90/580 (15%)

Query: 175 LTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 234
           L  S     +E   AL      N H +    +  L  A     V  V+ LL  G  V  H
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--H 238

Query: 235 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
            ++   L+ L  ACS G+YE+ + LL  H    +  +    TPL  A+S   +++  LLL
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297

Query: 293 LH-----------------------------------------DADVN------------ 299
            +                                         +ADV             
Sbjct: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357

Query: 300 -SQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
                T  TAL  A A  +     I ++LL +GANI +  +   TPL  A+   H +V  
Sbjct: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417

Query: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
           V++ H A +N   N   +++L  A Y GHL   R LL  G D    + +  TAL      
Sbjct: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472

Query: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTP 474
           G+  V +LL +  +  N  AD     L  AA  G VE +  L   +  N  ++     TP
Sbjct: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI--- 531
           L  AA      +V  LL  GA+++A+ ++     L  AC  G  EVA+ L+K GA +   
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
           +L   TPL EA+ +G  E+ K LL  GA+       G+T L    ++G TD+ D+L    
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLR--- 644

Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAV 650
                    G   L+ AA+ G L  V+ L S   NVN R T     T + LA    +L V
Sbjct: 645 ---------GDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEV 694

Query: 651 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
            E LL HGAD   + K G   L  AA  GH +V + L+ Y
Sbjct: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734



 Score =  119 bits (297), Expect = 5e-26
 Identities = 118/404 (29%), Positives = 166/404 (41%), Gaps = 80/404 (19%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
            T     T L  A   G +++V  L+   A ++ RD  G  PL  A + GH  VV +LL  
Sbjct: 54   TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL--------- 1161
            G D  A+ +    TPL  A   G+ +V  +LL  GA    RN    T L L         
Sbjct: 114  GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172

Query: 1162 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
                        A SG    ++ +L       ++  G K   +PL LAA    V  V+LL
Sbjct: 173  TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230

Query: 1210 LDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
            L  G+D++A+ +      L  AC  G  EV  LL+   A V        TPL EAAS   
Sbjct: 231  LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289

Query: 1270 AEVGRVLLDKGAD-----------VNAPPVP----------------------------- 1289
             EV  +LL  GAD           ++  P P                             
Sbjct: 290  VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349

Query: 1290 ------------SSRDTALTIAADKGHYK---FCELLIHRGAHIDVRNKKGNTPLWLASN 1334
                         + +TAL  AA   + K    CELL+ +GA+I+ + K+  TPL +AS 
Sbjct: 350  HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409

Query: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
              H DVV+++V+  A V+A DN   T L  A   GH++  + L+
Sbjct: 410  KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453



 Score =  113 bits (283), Expect = 2e-24
 Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 35/364 (9%)

Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
            PS       E   D  L  A +G  E+++++L   +      D +  TPL LAA    V 
Sbjct: 166  PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225

Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
            +V++LL  G D+ A+ ++    PL  ACS G  EV +LL+  GA     ++  +TPL  A
Sbjct: 226  IVQLLLQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284

Query: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
            AS   V +  +LL+ GA+   +N    S + ++P                L+ AA    V
Sbjct: 285  ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344

Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
              +K  L +   +N +      TAL  A    +  R ++  LLL + AN+  + K  LTP
Sbjct: 345  TRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403

Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
            L  A+   + +V  V++   A VNA  + +   T+L  AA  GH + C LL+  G   ++
Sbjct: 404  LHVASEKAHNDVVEVVVKHEAKVNA--LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461

Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL--V 1378
             + +G T L + +       VQ L+Q G  +   ++     L+ A + G V+ V+ L  V
Sbjct: 462  ISLQGFTALQMGNEN-----VQQLLQEG--ISLGNSEADRQLLEAAKAGDVETVKKLCTV 514

Query: 1379 KEVN 1382
            + VN
Sbjct: 515  QSVN 518



 Score =  113 bits (282), Expect = 3e-24
 Identities = 107/382 (28%), Positives = 161/382 (42%), Gaps = 69/382 (18%)

Query: 1055 HDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
            H+TAL  A A  +   +++  +L+ + A I  + K+  TPL +A+   H  VVE+++   
Sbjct: 364  HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423

Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
              + A  +    T L  A   G  +   LLL+ G +    ++  +T L +         +
Sbjct: 424  AKVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----V 477

Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
            + LL  G  + +    +     L+ AA  G V  VK L  + S     IE  ++T L  A
Sbjct: 478  QQLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533

Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
                R  VV  LL   A+V  + K GL PL  A S G+ EV  +L+  GA VN   +   
Sbjct: 534  AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL--W 591

Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRN----------------------------- 1322
            + T L  AA KG Y+ C+LL+  GA    +N                             
Sbjct: 592  KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651

Query: 1323 --KKG-----------------------NTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
              KKG                       +TPL LA+   + +V + L+Q GADV+A D  
Sbjct: 652  AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711

Query: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
             + PL +A   GHV V   L+K
Sbjct: 712  GLIPLHNAASYGHVDVAALLIK 733



 Score =  110 bits (275), Expect = 2e-23
 Identities = 107/315 (33%), Positives = 142/315 (45%), Gaps = 27/315 (8%)

Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
            S  D  L  A   G  E V  L    + +  RD +G   TPL  AA    V VVE LL  
Sbjct: 490  SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548

Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
            G D+ A+ ++    PL  ACS G  EV +LL+  GA     ++  +TPL  AA+ G   I
Sbjct: 549  GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607

Query: 1171 IKILLNAGAEIN--SRTGSK----------------LGISPLMLAAMNGHVPAVKLLLDM 1212
             K+LL  GA+    +R G+                  G + L+ AA  G +  VK L   
Sbjct: 608  CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667

Query: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
             +      +   +T L LA      EV   LL   A+V  + K GL PL  AAS G+ +V
Sbjct: 668  DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727

Query: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
              +L+   A VNA        T L  AA KG  + C LL+  GA   ++N++G TPL L 
Sbjct: 728  AALLIKYNACVNA--TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV 785

Query: 1333 SNGGHFDVVQLLVQA 1347
            S     DV  LL  A
Sbjct: 786  SAD---DVSALLTAA 797



 Score =  109 bits (272), Expect = 4e-23
 Identities = 99/342 (28%), Positives = 152/342 (44%), Gaps = 23/342 (6%)

Query: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
            K TPL  A   GR++VV+ LL  GAN + R+     PL  A S G+  ++ +LL  GA+ 
Sbjct: 58   KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP 117

Query: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
            N+R       +PL  AA+ G +    +LL  G++   +  T+  TAL LA          
Sbjct: 118  NAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR-NTDGRTALDLA---------- 164

Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
               D  A      +     L+E+A  G  E    LL    +VN       + T L +AA 
Sbjct: 165  ---DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAG 220

Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
                K  +LL+  GA +  ++K    PL  A + GH++V +LLV+ GA V+A D  + TP
Sbjct: 221  YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280

Query: 1362 LMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA-----TITDKELLKKCHQCVETIVKA 1416
            L  A  K  V+V   L+      P+ + C    A     T   KE L    +    +  A
Sbjct: 281  LHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAA 339

Query: 1417 KDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE 1458
            ++       K+ S+ +      ++ E +   A A+   KRK+
Sbjct: 340  READVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381



 Score =  108 bits (269), Expect = 9e-23
 Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 68/389 (17%)

Query: 1048 DAHTESNHDTA-LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            D H +   D   L  AC+ GH E+  +L+   A +   D   FTPL  AA+   V V  +
Sbjct: 236  DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 295

Query: 1107 LLDKGGD----------------------------------------------------- 1113
            LL  G D                                                     
Sbjct: 296  LLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355

Query: 1114 IEAQSERTKDTPLSLACSGG---RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
            +  +  +T +T L  A +     R+++ +LLL +GAN   +     TPL +A+   + ++
Sbjct: 356  VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDV 415

Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
            +++++   A++N+     LG + L  AA  GH+   +LLL  G D N  I     TAL +
Sbjct: 416  VEVVVKHEAKVNAL--DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM 472

Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
                G   V  LL +  +     A      L+EAA  G  E  + L    + VN   +  
Sbjct: 473  ----GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524

Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
             + T L  AA        E L+  GA +  ++K G  PL  A + GH++V +LLV+ GA 
Sbjct: 525  RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584

Query: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            V+ AD  K TPL  A  KG  ++ + L++
Sbjct: 585  VNVADLWKFTPLHEAAAKGKYEICKLLLQ 613



 Score =  107 bits (268), Expect = 1e-22
 Identities = 99/369 (26%), Positives = 155/369 (42%), Gaps = 52/369 (14%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
            T L +A    H ++V V++  +AK+   D  G T L  AA  GH+    +LL  G D   
Sbjct: 402  TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461

Query: 1114 -----------------------IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150
                                   I   +       L  A +G  + V  L   +  N   
Sbjct: 462  ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521

Query: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
                  TPL  AA    V++++ LL  GA+++++   K G+ PL  A   GH    +LL+
Sbjct: 522  IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLV 579

Query: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL--------- 1261
              G+ +N   +  + T L  A  +G+ E+  LLL   A+   + + G TPL         
Sbjct: 580  KHGAVVNVA-DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD 638

Query: 1262 -----------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
                       ++AA  G  A V +  L    +VN         T L +AA   + +  E
Sbjct: 639  IQDLLRGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696

Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
             L+  GA ++ ++K G  PL  A++ GH DV  LL++  A V+A D    TPL  A +KG
Sbjct: 697  YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756

Query: 1370 HVKVVQYLV 1378
              ++   L+
Sbjct: 757  RTQLCALLL 765



 Score =  107 bits (267), Expect = 1e-22
 Identities = 118/414 (28%), Positives = 177/414 (42%), Gaps = 49/414 (11%)

Query: 312 ACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
           AC  G V+ VK L+  E  N  D      TPL  AA  G  +V   LL +GA +    ++
Sbjct: 31  ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR-DD 89

Query: 371 FKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 430
                L  AC  GH ++V  LL  GAD   + +  +T L EA + G ++V  +LL  GA+
Sbjct: 90  GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149

Query: 431 VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE-MVAL 489
             +      + L LA       L           E   DE    L+E+AR G+EE M+AL
Sbjct: 150 PTIRNTDGRTALDLADPSAKAVLTG---------EYKKDE----LLESARSGNEEKMMAL 196

Query: 490 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEG 546
           L     N +A ++  + T L LA      ++   L++ GAD+   + G   PL  A   G
Sbjct: 197 LTPLNVNCHA-SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255

Query: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD------------- 593
           H E+ + L+  GA V+A      T L  A      +V  +LL  GAD             
Sbjct: 256 HYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAID 315

Query: 594 ----------LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
                     L +E +G    L++AAR   +  ++  +S    VN        T +  A 
Sbjct: 316 LAPTPQLKERLAYEFKGHS--LLQAAREADVTRIKKHLSLEM-VNFKHPQTHETALHCAA 372

Query: 644 AGGH---LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
           A  +     + ELLL  GA+   + K+  T L  A++  H +VV  ++ +   V
Sbjct: 373 ASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKV 426



 Score =  106 bits (264), Expect = 3e-22
 Identities = 100/293 (34%), Positives = 137/293 (46%), Gaps = 28/293 (9%)

Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
           R L EA   GDV  V+KL    +SVN    EG     L  +AGY  ++ V  LL   A+V
Sbjct: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
             + +KG + PL  A S G+ ++ +LL+ H A VN       T L  A A G  +I K+L
Sbjct: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611

Query: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVL-LDHGAG 363
           L  GA+    N +G+TPL                    ++AA  G +  ARV  L     
Sbjct: 612 LQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCL--ARVKKLSSPDN 669

Query: 364 INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 422
           +N    + + S  L LA    +L++  +LL+ GAD   +       L  A   GHV+VA 
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729

Query: 423 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475
           LL+   A VN       +PL  AA  G  +L ALL+  GA+    N EG TPL
Sbjct: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 72/211 (34%), Positives = 93/211 (44%), Gaps = 31/211 (14%)

Query: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
            L  A  NG V  VK L+      +      ++T L  A   GR +VV  LL   ANV+ R
Sbjct: 28   LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87

Query: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1309
               GL PL  A S G+AEV  +LL  GAD      P++RD    T L  AA KG    C 
Sbjct: 88   DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141

Query: 1310 LLIHRGAHIDVRNKKGNTPLWLAS---------------------NGGHFDVVQLLVQAG 1348
            +L+  GA   +RN  G T L LA                      +G    ++ LL    
Sbjct: 142  VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201

Query: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
             +  A+D RK TPL  A     VK+VQ L++
Sbjct: 202  VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  158 bits (400), Expect = 6e-38
 Identities = 130/382 (34%), Positives = 178/382 (46%), Gaps = 6/382 (1%)

Query: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
           G  E  ++LLA   +V+ +   G  TPL+ A+     D+  LLL H AD N     G   
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
           L +A   G     ++LL+ GA ++     G TPL  AA      VAR+L+   A  N H 
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
            E K + L +A Y GH+ +V+ L   GA+ + +   + T L  A   G V   + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550

Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
           A  +    S   PL  AA  G   +  +L+  GA+LE    +G+TPL  AA +GH E++ 
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610

Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
           LL    AN+ A       T L LA   G   V   L++ GAD    E    TPL  A Q 
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669

Query: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
                V  LL   ANVHA    G T    A   G+T +  VL++AGA L+ +     TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729

Query: 606 MKAARAGHLCTVQFLISKGANV 627
             A R+     + FL  K  +V
Sbjct: 730 QLALRSRKQGIMSFLEGKEPSV 751



 Score =  151 bits (382), Expect = 7e-36
 Identities = 126/415 (30%), Positives = 186/415 (44%), Gaps = 33/415 (7%)

Query: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
           +TPL    + G ++ V+LLL H+ DV+ Q+A+G T L  A      D+  +LL  GA+  
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
             +E+G  PL  AA  G    AR+LLDHGA ++    E   + L LA      ++ R L+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481

Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
              AD      E  T L  A   GHV + +LL   GA+++    +  +PL LA   G V 
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541

Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
               L++ GA  + ++  GY PL  AA  G   +  +LL  GA++   T +         
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594

Query: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
                                   TPL  A+ +GHLE++  L  S AN+ A  A   T L
Sbjct: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630

Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
             A  +G   V   LLQ GAD     + G TPL  A +     +V  L+   ANV+ A  
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARN 689

Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
               T   LA   G+ A++++L+  GA    +     T L  A +     ++S+L
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  145 bits (366), Expect = 5e-34
 Identities = 117/365 (32%), Positives = 171/365 (46%), Gaps = 38/365 (10%)

Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
            VD+D  T S + T L +A      +L ++L+A  A     D+ G+ PL  AA  G  G  
Sbjct: 386  VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444

Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
             +LLD G  ++AQ ER   TPL LA     + V  LL++R A+         TPL +AA 
Sbjct: 445  RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503

Query: 1165 GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 1193
             G+V+++K+L + GAE+     N RT   L                          G  P
Sbjct: 504  FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563

Query: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEH 1252
            L  AA  G     K+LL  G+ +  ++ T++  T L LA ++G  E++ LL +  AN+  
Sbjct: 564  LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621

Query: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
                  TPL  AA  G   V   LL  GAD NA     S  T L +A  +  +     L+
Sbjct: 622  LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679

Query: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
               A++  RNK G TP  LA+  G+  ++++LV+AGA +D  D    TPL  A R     
Sbjct: 680  EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739

Query: 1373 VVQYL 1377
            ++ +L
Sbjct: 740  IMSFL 744



 Score =  134 bits (336), Expect = 1e-30
 Identities = 106/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)

Query: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
            N  T L    A G  E V +L+A +  ++ +   G+TPL++AA      +  +LL  G D
Sbjct: 361  NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420

Query: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
                 E     PL  A   G      LLL  GA  + +    +TPL LAA   + N+ ++
Sbjct: 421  ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479

Query: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
            L++  A+ N       G +PL +AA  GHV  VKLL   G++++AQ + N  T L LA  
Sbjct: 480  LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536

Query: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
            +G+   +  LL   A  +   ++G  PL  AA+ G   + ++LL  GA +  P       
Sbjct: 537  RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594

Query: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
            T L +AA KGH +   LL    A++        TPL LA+  G   VV  L+Q GAD +A
Sbjct: 595  TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654

Query: 1354 ADNRKITPL-MSAFRKGHVKVVQYLVKEVN 1382
            A+    TPL ++  R   + V+  L    N
Sbjct: 655  AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684



 Score =  127 bits (318), Expect = 2e-28
 Identities = 115/367 (31%), Positives = 168/367 (45%), Gaps = 9/367 (2%)

Query: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390
           NE+    LM++ S  +++ A  L D    +         E K + L     +G ++ VR 
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380

Query: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
           LL    D + +T   +T L+ A  D   ++  LLL  GA  N   +   +PL  AA  G 
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440

Query: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
              A LL++ GA ++    EG+TPL  AA+   E +  LL+++ A+ N   E   +T L 
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499

Query: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567
           +A   G   +   L   GA+++       TPL  A + G +  +++LL SGA   A   +
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559

Query: 568 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627
           G   L  A   G   +  +LL+ GA LE  +  G TPL  AA  GHL  +  L    AN+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619

Query: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
               A N  T + LA   G  AVV  LL  GADP    + G T L  A +      V  L
Sbjct: 620 GALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678

Query: 688 LDYPNNV 694
           L++  NV
Sbjct: 679 LEHHANV 685



 Score =  117 bits (293), Expect = 1e-25
 Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)

Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
           A  +GD    R LLD G  V+    EG + L LA    +  +A++L++  A+      +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494

Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
             TPL  A+  G++ +VKLL    A++++Q     T L  A   G V  ++ LL  GA  
Sbjct: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
           +  +++G+ PL  AA+ G   + ++LL +GA +   +++   + L LA YKGHL+++  L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
            E+ A+         T L  A   G   V   LL  GA  N    S  +PL LA      
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672

Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
                L+E  AN+   N  G+TP   AA +G+  ++ +L+  GA ++ Q
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721



 Score = 75.5 bits (184), Expect = 6e-13
 Identities = 55/161 (34%), Positives = 78/161 (48%), Gaps = 2/161 (1%)

Query: 1220 IETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1279
            I  N+ T L     QG  E V LLL  + +V+ +  +G TPL+ AA     ++  +LL  
Sbjct: 358  IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 1280 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD 1339
            GAD N   V       L  AA  G      LL+  GA +D + ++G TPL LA+     +
Sbjct: 418  GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475

Query: 1340 VVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            V +LLV   AD +  +    TPL  A   GHV +V+ L  +
Sbjct: 476  VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516



 Score = 46.2 bits (108), Expect = 4e-04
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 1/134 (0%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L LA   G E +VS L+   A     ++ G+TPL LA        V  LL+   ++ A
Sbjct: 628  TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687

Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
            ++ +   TP  LA   G   ++ +L+  GA  + ++    TPL LA       I+  L  
Sbjct: 688  RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746

Query: 1177 AGAEINSRTGSKLG 1190
                + +  GSK G
Sbjct: 747  KEPSVATLGGSKPG 760


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  158 bits (400), Expect = 6e-38
 Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)

Query: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
           LS    G       PE  +R   E+ L ++G GK     G +  D     R + S+S   
Sbjct: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393

Query: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
           + + + L             V  + L +A   GD + + K+L + + V+   + G SLL 
Sbjct: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443

Query: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
           LA  AG  E A+ LL  +AN      +G  TPL  A       +V+LLL     VN++  
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502

Query: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
              TAL +A   G     ++LL + A++ + +  G TP+  A   G   + R+LL  G  
Sbjct: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562

Query: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
           ++      K++ L L  A ++GHL +V+ L  + G     +T +  T L  A   GH  V
Sbjct: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619

Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
           AR+L+D  + VN+ +   ++PL +AA  GH   A LL+ RGA  E +  +GYT L  AAR
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679

Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
            GH   V LL+ + A++ A+    Q TAL LA   G SEV + L+ A   D+  E G S 
Sbjct: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738

Query: 538 PLMEASQEGHLELVKYLLASGANVH 562
            L  A+Q  H + V+ LL  GA+++
Sbjct: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  139 bits (349), Expect = 5e-32
 Identities = 118/370 (31%), Positives = 176/370 (47%), Gaps = 10/370 (2%)

Query: 1011 SNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEEL 1070
            S S   TT+    +      S   S+ M  + P  D+D   +S   + L LA   G EE 
Sbjct: 396  STSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSGA-SLLHLAVEAGQEEC 453

Query: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
               L+  +A     +++G TPL +A      GVVE+LL +   + A+ E  + T L  A 
Sbjct: 454  AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAA 512

Query: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
              G +    LLL + A+    +    TP+ +A   G  NI++ILL  G +++ +   K  
Sbjct: 513  QNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDA 570

Query: 1191 ISPLMLAAMNGHVPAVKLLLDM-GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
              PL  AA  GH+P VKLL    G  +NAQ    R T L LA  +G   V  +L+D  ++
Sbjct: 571  WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSD 629

Query: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
            V   +    TPL  AA  G+    R+LL +GA   A  + S   TAL +AA  GH    +
Sbjct: 630  VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVK 687

Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
            LL+   A +  R     T L LA+  GH +VV+ LV A   +D  D + ++ L  A +  
Sbjct: 688  LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGR 746

Query: 1370 HVKVVQYLVK 1379
            H + V+ L++
Sbjct: 747  HAQTVETLLR 756



 Score =  127 bits (319), Expect = 1e-28
 Identities = 109/329 (33%), Positives = 155/329 (47%), Gaps = 10/329 (3%)

Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
           ++G + L  A  AG  E A+ LL + A  N  SN    + L +A  +    +V  LL   
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494

Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
                K ++  TAL  A  +G     RLLL+  A VN       +P+ +A   G   +  
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
           +L+ RG ++     + + PL  AA +GH  +V LL  Q G ++NAQT + + T L LA  
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613

Query: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
            G   VA  LI   +D+ + CS    TPL  A++ GH    + LL  GA   A T+ G T
Sbjct: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672

Query: 571 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
           AL  A  NGH     +L++  AD+       +T L  AA  GH   V+ L+S  A+V   
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS--ADVIDL 730

Query: 631 TANNDHTVVSLACAGGHLAVVELLLAHGA 659
                 + + LA  G H   VE LL HGA
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGA 759



 Score =  122 bits (305), Expect = 6e-27
 Identities = 92/297 (30%), Positives = 147/297 (49%), Gaps = 8/297 (2%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L +A       +V +L+AR   +  +D+  +T L  AA  G      +LL+K   +  
Sbjct: 473  TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532

Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
                 + TP+ +AC  G++ +V +LL RG +   +    + PL  AA  G++ I+K+L  
Sbjct: 533  VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591

Query: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
              G  +N++T    G +PL LAA  GH    ++L+D+ SD+N        T L +A   G
Sbjct: 592  QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
                  LLL R A  E     G T L  AA  G+    ++L+++ ADV A        TA
Sbjct: 649  HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706

Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
            L +AA  GH +  E L+     ID+ +++G + L LA+ G H   V+ L++ GA ++
Sbjct: 707  LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score =  112 bits (279), Expect = 6e-24
 Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 17/278 (6%)

Query: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA 1163
            V++ LD G  +           L LA   G++E    LL   AN    N    TPL +A 
Sbjct: 431  VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479

Query: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
                  ++++LL     +N++   +   + L  AA NG   + +LLL+  + +N +++  
Sbjct: 480  ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536

Query: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1282
              T + +AC  G+  +V +LL R  +V  + K    PL  AA  G+  + ++L  + G  
Sbjct: 537  GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596

Query: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
            VNA  +     T L +AA +GHY+   +LI   + ++V +    TPL +A+  GH    +
Sbjct: 597  VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654

Query: 1343 LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            LL+  GA  +A  +   T L  A R GH+  V+ LV+E
Sbjct: 655  LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692



 Score =  110 bits (276), Expect = 1e-23
 Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)

Query: 36  GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
           GV   +        +   S + SSG G   SG    D+A   +  L+ +  R        
Sbjct: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401

Query: 94  GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
            +D  +   V++ +  D   L   +     ++ L S A    L     + +     LL  
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
           A    LS   G       V RR+   V   L  A       K E+   A       L  A
Sbjct: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511

Query: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
             +GD ++ R LL++  SVNE   EG + + +AC  G   + ++LL    +V  +G K  
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570

Query: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
             PL  A+  G+L IVKLL       VN+Q+  G T L  A   G   + ++L++  +++
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630

Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
              +    TPL  AA  GH   AR+LL  GAG    +++   +AL LA   GHL  V+ L
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689

Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
           +E  AD   +     TAL  A   GH EV   L+ S   +++  +   S L LAA G H 
Sbjct: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748

Query: 452 ELAALLIERGA--NLEEVNDEG 471
           +    L+  GA  NL+ +  +G
Sbjct: 749 QTVETLLRHGAHINLQSLKFQG 770



 Score =  107 bits (267), Expect = 1e-22
 Identities = 93/299 (31%), Positives = 133/299 (44%), Gaps = 7/299 (2%)

Query: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
           TD     L++A + G       +L     V++  DS  S L LA   G  E A  L+   
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
           AN    N  G TPL  A       +V LLLA+  ++NA+ E+ Q TAL  A   G     
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520

Query: 522 DFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
             L++  A   +++    TP+  A Q G   +V+ LL  G +V          L YA   
Sbjct: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580

Query: 579 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
           GH  +  +L  Q G  +  ++  GRTPL  AA+ GH    + LI   ++VN  +     T
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639

Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
            + +A   GH +   LLL  GA       DG T L  AA+ GH   V  L++   +VL+
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698



 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 57/185 (30%), Positives = 78/185 (42%), Gaps = 32/185 (17%)

Query: 1066 GHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
            GH  +V +L  +    +  +   G TPL LAA  GH  V  IL+D   D+   S   + T
Sbjct: 581  GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639

Query: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
            PL +A   G      LLL RGA KE      YT L LAA  G++  +K+L+   A++ +R
Sbjct: 640  PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699

Query: 1185 TG------------------------------SKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
                                             + G+S L LAA   H   V+ LL  G+
Sbjct: 700  GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759

Query: 1215 DINAQ 1219
             IN Q
Sbjct: 760  HINLQ 764



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 58/203 (28%), Positives = 87/203 (42%), Gaps = 3/203 (1%)

Query: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
           T + Q+  L  A   G  S++   L     D+ L     L+  + E G  E  K+LL + 
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461

Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
           AN + +   G T L  A E     V ++LL     +  + E   T L  AA+ G   + +
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTR 521

Query: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
            L+ K A+VN        T + +AC  G   +V +LL  G D + + KD    L  AA  
Sbjct: 522 LLLEKNASVNEVDFEG-RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580

Query: 679 GHTNVVSYLLDYPNNVLSVPTTD 701
           GH  +V  L   P   ++  T D
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLD 603



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 12/153 (7%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
            T L +A   GH     +L+ R A  E     G+T L LAA  GH+  V++L+++  D+ A
Sbjct: 639  TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698

Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
            +      T L LA + G  EVV+ L++     +  +    + L LAA G +   ++ LL 
Sbjct: 699  RGP-LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756

Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
             GA IN ++          L    GH PA  LL
Sbjct: 757  HGAHINLQS----------LKFQGGHGPAATLL 779


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  149 bits (375), Expect = 4e-35
 Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)

Query: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 907  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966

Query: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 967  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025

Query: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085

Query: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138

Query: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174

Query: 573  TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
            ++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +     
Sbjct: 1175 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1232

Query: 633  NNDHT---VVSLACAGGHLAVVELLLAHGA 659
              DH+    +  A    + +VV  LL  GA
Sbjct: 1233 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score =  139 bits (349), Expect = 5e-32
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
            Y  ++ + R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 901  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960

Query: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL       
Sbjct: 961  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020

Query: 493  --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
              Q   +  +     + ALT A   G S V   L+    + E+  +        T L  A
Sbjct: 1021 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1078

Query: 543  SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
            +  G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GR
Sbjct: 1079 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1138

Query: 603  TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
            TPLM AA  GHL TV+FL+SKGA ++ +      + +S AC  GH AVV+ L+  GA   
Sbjct: 1139 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197

Query: 663  HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
               K+G T L  AA  G    V YL++
Sbjct: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVE 1224



 Score =  131 bits (330), Expect = 7e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 963  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022

Query: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261

Query: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589
            +      G+ A  +A      D+  +LLQ
Sbjct: 1262 L------GNAA--WAMATSKPDILIILLQ 1282



 Score =  129 bits (323), Expect = 5e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 938  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L AA+S G+  +V+ LL    
Sbjct: 998  VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057

Query: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117

Query: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176

Query: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236

Query: 472  YTPLMEAAREGHEEMVALLLAQGANI 497
              PL  A    +  +V  LL +GA +
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262



 Score =  120 bits (300), Expect = 2e-26
 Identities = 108/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
            T  N  TAL  A A GH +LV +L  +  +++H DKKG   L+ +A  GH  +++ LL  
Sbjct: 956  TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1015

Query: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156
                   + G +  +        L+ A S G   VV  LL  G  KEH    N +D    
Sbjct: 1016 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1071

Query: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
             T L+ AA  G + + ++LL  GA + SRT  + G+ PL  AA                 
Sbjct: 1072 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR---------------- 1113

Query: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
                              QG  ++V LLL+R  +V    K G TPLM AA  G+      
Sbjct: 1114 ------------------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1155

Query: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
            LL KGA +++  +     +AL+ A  KGH    + L+  GA ID  +K G TPL LA+  
Sbjct: 1156 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213

Query: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            G  + V  LV+ GA ++  D+  + PL  A    +  VV  L+++
Sbjct: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)

Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
            L + +  GH  VV +LL+ G  ++  SE    T L  A + G  ++V LL  +G   +H 
Sbjct: 931  LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 989

Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
            +      L  +A  G+ +I++ LL             L  S      L  AA  GH   V
Sbjct: 990  DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1049

Query: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
            + LL M  +   ++         TALT A  +G+ EV  LLL   A V    + G+ PL 
Sbjct: 1050 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1109

Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
             AA  G+ ++ R+LL++G DVN         T L +AA +GH    E L+ +GA +   +
Sbjct: 1110 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1167

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            K+G + L  A   GH  VVQ LV+ GA +D  D    TPL  A   G  + V YLV++
Sbjct: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1225



 Score =  110 bits (275), Expect = 2e-23
 Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)

Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
            +V V  +L+  G ++  ++E   + P+    S  G +EVV LLL  GA  +  + +  T 
Sbjct: 904  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963

Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
            L  AA+ G++ ++ +L   G  ++     K G   L+ +A+ GH   ++ LL    S   
Sbjct: 964  LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021

Query: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
             Q  T R +     ALT A   G + VV  LL  +   EH  +        G T L  AA
Sbjct: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079

Query: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
              G  EV  +LL  GA V   N   VP      L  AA +GH++   LL+ RG  +++ +
Sbjct: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            K+G TPL +A+  GH   V+ L+  GA + + D   ++ L  A  KGH  VVQYLV+E
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192



 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 66/226 (29%), Positives = 100/226 (44%), Gaps = 37/226 (16%)

Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
            +TALT A   G  E+  +L+   A +   +++G  PL  AA  GH  +V +LL++G D+ 
Sbjct: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131

Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
              S++   TPL +A   G    V+ LL++GA     +    + LS A   G+  +++ L+
Sbjct: 1132 L-SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1190

Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
              GA I+     K G +PL LAA                                  F G
Sbjct: 1191 EEGAAIDQT--DKNGRTPLDLAA----------------------------------FYG 1214

Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
             AE V  L+++ A +EH   +G+ PL  A       V   LL KGA
Sbjct: 1215 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133

Query: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193

Query: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252

Query: 322  KVLLNEGANI 331
              LL +GA +
Sbjct: 1253 VALLRKGAKL 1262


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  149 bits (375), Expect = 4e-35
 Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)

Query: 287  IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
            + +LL+L  A+VN ++   N A  L      G  ++V +LL  GA ++  +ENG T L  
Sbjct: 915  VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974

Query: 345  AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
            AA+AGH+++  +L   G  ++ H ++  + AL  +  +GH D++++LL      G  Q  
Sbjct: 975  AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033

Query: 400  --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
               K+  +  AL  A   GH  V + LL    +  +  +       E+ LT AA  G +E
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093

Query: 453  LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
            +  LL+  GA +   N  G  PL  AAR+GH ++V LLL +G ++N   ++ +       
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146

Query: 513  CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
                                    TPLM A+ EGHL  V++LL+ GA + +    G +AL
Sbjct: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182

Query: 573  TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
            ++AC  GH  V   L++ GA ++   + GRTPL  AA  G   TV +L+ KGA +     
Sbjct: 1183 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1240

Query: 633  NNDHT---VVSLACAGGHLAVVELLLAHGA 659
              DH+    +  A    + +VV  LL  GA
Sbjct: 1241 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268



 Score =  139 bits (349), Expect = 5e-32
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)

Query: 381  YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
            Y  ++ + R L+  GA+  ++T+ ++ A +       GH EV  LLL+ GA ++  +++ 
Sbjct: 909  YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968

Query: 439  ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
             + L  AA  GH++L  LL ++G  ++ ++ +G   L+ +A  GH +++  LL       
Sbjct: 969  MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028

Query: 493  --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
              Q   +  +     + ALT A   G S V   L+    + E+  +        T L  A
Sbjct: 1029 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1086

Query: 543  SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
            +  G LE+ + LL  GA V  T   G   L  A   GH  +  +LL+ G D+    + GR
Sbjct: 1087 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1146

Query: 603  TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
            TPLM AA  GHL TV+FL+SKGA ++ +      + +S AC  GH AVV+ L+  GA   
Sbjct: 1147 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205

Query: 663  HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
               K+G T L  AA  G    V YL++
Sbjct: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVE 1232



 Score =  131 bits (330), Expect = 7e-30
 Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)

Query: 217  DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
            +V   R L+  G +VN  TE      +LC+    G+ E+  +LL   A ++     G +T
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970

Query: 275  PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
             L  A++ G++ +V LL      V+     G  AL ++   G  DI++ LL    + G  
Sbjct: 971  ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030

Query: 331  IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
                    H     L  AAS GH  V + LL    +H   +N     + E+ALT A  +G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090

Query: 384  HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
             L++   LL  GA            L  A   GH ++ RLLL+ G  VN+      +PL 
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150

Query: 444  LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
            +AAC GH+     L+ +GA L  ++ EG + L  A  +GH  +V  L+ +GA I+ QT++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209

Query: 504  TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
               T L LA   G +E   +L++ GA IE        PL  A    +  +V  LL  GA 
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269

Query: 561  VHATTATGDTALTYACENGHTDVADVLLQ 589
            +      G+ A  +A      D+  +LLQ
Sbjct: 1270 L------GNAA--WAMATSKPDILIILLQ 1290



 Score =  129 bits (323), Expect = 5e-29
 Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)

Query: 216  GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
            G    V  LL+ G  ++  +E G + LC A +AG+ +L  +L      V+    KG    
Sbjct: 946  GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005

Query: 275  --------------------------------------PLMAASSGGYLDIVKLLL---- 292
                                                   L AA+S G+  +V+ LL    
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065

Query: 293  LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
             H+ +VN + +  G TALT A   G +++ ++LL  GA +   N  G  PL  AA  GH 
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125

Query: 352  EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
            ++ R+LL+ G  +N    + +   +  AC +GHL  V FLL  GA       E  +AL  
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184

Query: 412  ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
            AC+ GH  V + L++ GA ++    +  +PL LAA  G  E    L+E+GA +E V+  G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244

Query: 472  YTPLMEAAREGHEEMVALLLAQGANI 497
              PL  A    +  +V  LL +GA +
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270



 Score =  120 bits (302), Expect = 1e-26
 Identities = 140/497 (28%), Positives = 221/497 (44%), Gaps = 66/497 (13%)

Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL-- 1108
            T  N  TAL  A A GH +LV +L  +  +++H DKKG   L+ +A  GH  +++ LL  
Sbjct: 964  TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1023

Query: 1109 ------DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSD---- 1155
                   + G +  +        L+ A S G   VV  LL  G  KEH    N +D    
Sbjct: 1024 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1079

Query: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
             T L+ AA  G + + ++LL  GA + SRT ++ G+ PL  AA  GH   V+LLL+ G D
Sbjct: 1080 ETALTAAAGRGKLEVCELLLGHGAAV-SRT-NRRGVPPLFCAARQGHWQIVRLLLERGCD 1137

Query: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
            +N   +  R   +  AC +G    V  LL + A +    K GL+ L  A   G+  V + 
Sbjct: 1138 VNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1196

Query: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
            L+++GA ++      +  T L +AA  G  +    L+ +GA I+  +  G  PL  A   
Sbjct: 1197 LVEEGAAID--QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC 1254

Query: 1336 GHFDVVQLLVQAGADVDAA--------DNRKITPLMSAFRKGHVKVVQYLVKEVNQ---- 1383
             +  VV  L++ GA +  A         +  I  L     +G+V   +  +KE  Q    
Sbjct: 1255 RNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQY 1314

Query: 1384 ----FPSD--IECMRYIATITDKEL--LKKCHQCVETIVKAKDQQAAEANKNASILLKEL 1435
                FP +   E MR    +       L +C +      K  D   AE   + ++ LK  
Sbjct: 1315 ALRKFPREGFGEDMRPFNELRVSLYLNLSRCRR------KTNDFGMAEEFASKALELKPK 1368

Query: 1436 DLE------KSREESRK--QALAAKRE-------KRKEKRKKKKEEQKRKQEEDEENKPK 1480
              E      +++  SR+   ALA  +E        ++ KR   + E++ KQ +  + + K
Sbjct: 1369 SYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQ-K 1427

Query: 1481 ENSELPEDEDEEENDED 1497
            +   LP   ++ EN+ED
Sbjct: 1428 QQGPLPAPLNDSENEED 1444



 Score =  117 bits (293), Expect = 1e-25
 Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)

Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
            L + +  GH  VV +LL+ G  ++  SE    T L  A + G  ++V LL  +G   +H 
Sbjct: 939  LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 997

Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
            +      L  +A  G+ +I++ LL             L  S      L  AA  GH   V
Sbjct: 998  DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1057

Query: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
            + LL M  +   ++         TALT A  +G+ EV  LLL   A V    + G+ PL 
Sbjct: 1058 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1117

Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
             AA  G+ ++ R+LL++G DVN         T L +AA +GH    E L+ +GA +   +
Sbjct: 1118 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1175

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            K+G + L  A   GH  VVQ LV+ GA +D  D    TPL  A   G  + V YLV++
Sbjct: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1233



 Score =  110 bits (275), Expect = 2e-23
 Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)

Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
            +V V  +L+  G ++  ++E   + P+    S  G +EVV LLL  GA  +  + +  T 
Sbjct: 912  NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971

Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
            L  AA+ G++ ++ +L   G  ++     K G   L+ +A+ GH   ++ LL    S   
Sbjct: 972  LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029

Query: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
             Q  T R +     ALT A   G + VV  LL  +   EH  +        G T L  AA
Sbjct: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087

Query: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
              G  EV  +LL  GA V   N   VP      L  AA +GH++   LL+ RG  +++ +
Sbjct: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142

Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
            K+G TPL +A+  GH   V+ L+  GA + + D   ++ L  A  KGH  VVQYLV+E
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)

Query: 148  ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
            AL  AAG GKL   +   G   A     RR    + CA  +    + R+  E   +    
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141

Query: 205  DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
            D +    L  A  +G ++ V  LL +G +++   +EG S L  AC  G+  + Q L+   
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201

Query: 262  ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
            A + D+ +K   TPL  A+  G  + V  L+   A +     +G   L  A       +V
Sbjct: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260

Query: 322  KVLLNEGANI 331
              LL +GA +
Sbjct: 1261 VALLRKGAKL 1270


>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score =  148 bits (374), Expect = 6e-35
 Identities = 138/415 (33%), Positives = 188/415 (45%), Gaps = 52/415 (12%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160

Query: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220

Query: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280

Query: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340

Query: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+   ++ G T
Sbjct: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395



 Score =  132 bits (333), Expect = 3e-30
 Identities = 110/338 (32%), Positives = 161/338 (47%), Gaps = 26/338 (7%)

Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
            V +D   E+ + TAL  A AGGHE LV  L+ R A +  R+  G++ L+ AA  GHV V 
Sbjct: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127

Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
             +LLD G D+ AQ+ R   + L++A  GG   VV LLL  GA  +H + S    L L  S
Sbjct: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185

Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
                                    L I+ LM A  +GH   V+LL++ G+D N    T  
Sbjct: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225

Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284

Query: 1285 APPVPSSRDTALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
                   R   +  A   G+++   E+     +H+++ N  G TPL LA+  G   +VQL
Sbjct: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344

Query: 1344 LVQAGADVDAADN-RKITPLMSAFRKGHVKVVQYLVKE 1380
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382



 Score =  126 bits (316), Expect = 3e-28
 Identities = 121/386 (31%), Positives = 173/386 (44%), Gaps = 27/386 (6%)

Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH- 367
           L  AC  G  +  + LL  GA   +  E G  P   A  AG  EVA         +    
Sbjct: 13  LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAG-AEVAGPGAAAAGAVGAPV 69

Query: 368 ----SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
               S+E   +AL  A   GH  +VRFLL  GA    +     +ALM+A   GHV VA L
Sbjct: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129

Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG------------ 471
           LLD GA VN       S LT+A+ GGH+ +  LL+E GA ++  +  G            
Sbjct: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189

Query: 472 --YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
              T LM A + GHE +V LL+  GA+ N        + L LA   G   VA  L++ GA
Sbjct: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249

Query: 530 D---IELGCSTPLMEASQEGHLELVKYL-LASGANVHATTATGDTALTYACENGHTD-VA 584
           +   + +   T    A    H +LV YL   +              + +A + G+   V 
Sbjct: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309

Query: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
           ++  +  + +   +  G TPLM AA  G L  VQ L+ + A+V++  + +  T +  A  
Sbjct: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369

Query: 645 GGHLAVVELLLAHGADPTHRLKDGST 670
            G+  +V+ LL  GAD T R K+G T
Sbjct: 370 HGNKEIVKYLLNQGADVTLRAKNGYT 395



 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 81/295 (27%), Positives = 128/295 (43%), Gaps = 61/295 (20%)

Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKG--------------FTPLILAATAGHVG 1102
            + LT+A  GGH  +V +L+   A ++H    G               T L+ A   GH  
Sbjct: 146  SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEA 205

Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
            VV +L++ G D    +     +PL LA   GR  V   L+ +GAN +H +V + T   +A
Sbjct: 206  VVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVA 265

Query: 1163 ASGGYVNIIKIL----------------------LNAG-------------AEINSRTGS 1187
                + +++  L                      L  G             + +N   G 
Sbjct: 266  LDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGD 325

Query: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247
              G +PLMLAA+ G +  V+LL++  +D++ Q   +  TAL  A + G  E+V  LL++ 
Sbjct: 326  --GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQG 383

Query: 1248 ANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAPPVPSSR 1292
            A+V  RAK G T   L+   +    E+ R+L         DKG   + PP+P S+
Sbjct: 384  ADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSK 438



 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 75/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)

Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72

Query: 535 CS-----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
           CS     T L  A+  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132

Query: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-------------DH 636
            GAD+  ++  G + L  A+R GHL  V+ L+  GA V+    +              D 
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192

Query: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTNVVSYLLD 689
           T +  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++
Sbjct: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 57/156 (36%), Positives = 73/156 (46%), Gaps = 7/156 (4%)

Query: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1286
            L  AC QG  E    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69

Query: 1287 PVPSSRD---TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  A+  GH  V  L
Sbjct: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129

Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165



 Score = 49.7 bits (117), Expect = 4e-05
 Identities = 41/127 (32%), Positives = 57/127 (44%), Gaps = 6/127 (4%)

Query: 572 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT 631
           L  AC+ G T+ A  LL+ GA     +E G  P   A  AG         + GA      
Sbjct: 13  LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70

Query: 632 ANND----HTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
            +      +T +  A AGGH  +V  LL  GA    R   G + L++AA+ GH +V   L
Sbjct: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130

Query: 688 LDYPNNV 694
           LD+  +V
Sbjct: 131 LDHGADV 137


>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
           sapiens]
          Length = 587

 Score =  140 bits (353), Expect = 2e-32
 Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)

Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
           L +A  DGD  A++ ++ EG+++ E  +EG   L  A   G     +VL   +    D+ 
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
              + T +  A+  G+LD +  LL   A+ +  + +  T L  AC     + VK+L+   
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
           A+       G T L E+ S   +EV ++L+  GA + +  N +  + L +A   G L+ +
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239

Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
           RFL + GAD   +  +  +AL EAC + H EV   LL  GA  N        PL +A+  
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299

Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
           G+  +  +L+    +   +   G +PL  AA   H+E++  LL+   ++N          
Sbjct: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358

Query: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
            E+ + +AL  A         + L++ GAD      +PL+ A + G L  ++ LL  GAN
Sbjct: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418

Query: 561 VHATTATGDTA 571
           + A  AT  TA
Sbjct: 419 IDAYIATHPTA 429



 Score =  119 bits (299), Expect = 3e-26
 Identities = 88/258 (34%), Positives = 127/258 (49%), Gaps = 8/258 (3%)

Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
           PAD    PL  A   G  E    +I+ G NL E N EG+ PL EAA  G    + +L   
Sbjct: 57  PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112

Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
                 Q    +ETA+ LA C G  +    L++AGA+ ++      TPL +A +  + E 
Sbjct: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172

Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
           VK L+   A+ +     G TAL  +      +V  +L+  GA +E ++  G TPL  AA+
Sbjct: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232

Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
           +G L  ++FL   GA++N   ++N   +   AC   H  VVE LL+ GAD     KDG  
Sbjct: 233 SGQLEALRFLAKYGADINTQASDNASALYE-ACKNEHEEVVEFLLSQGADANKTNKDGLL 291

Query: 671 MLIEAAKGGHTNVVSYLL 688
            L  A+K G+  +V  LL
Sbjct: 292 PLHIASKKGNYRIVQMLL 309



 Score =  119 bits (298), Expect = 4e-26
 Identities = 110/397 (27%), Positives = 181/397 (45%), Gaps = 49/397 (12%)

Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
           L  A   G  + +K ++ EG N+ + N+ G  PL EAA  G V   +VL     G     
Sbjct: 61  LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120

Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQE---------------------------HK 401
              +E+A+ LA  +GHLD +  LL+AGA+ +                           H 
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180

Query: 402 TDEMH------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
            D  H      TAL E+     +EV ++L+  GA+V        +PL +AA  G +E   
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240

Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
            L + GA++     +  + L EA +  HEE+V  LL+QGA+ N +T +     L +A   
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIASKK 299

Query: 516 GFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA------- 566
           G   +   L+   +   +  S  +PL  A++  H E+++ LL++  +V+   A       
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359

Query: 567 --TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
                +AL +A  N +    ++LLQ GAD   +     +PL+ A R G L T+Q L+  G
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLLDHG 416

Query: 625 ANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGAD 660
           AN++   A +      ++  A   L++++ L+  G D
Sbjct: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453



 Score =  112 bits (279), Expect = 6e-24
 Identities = 90/309 (29%), Positives = 152/309 (49%), Gaps = 23/309 (7%)

Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
            I+ R  +  T + LA   GH+  +  LL  G + +  S ++++TPL  AC     E V +
Sbjct: 117  IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKI 175

Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
            L+   A+  HR    +T L  + S   + +++IL++ GA++ S+  +  GI+PL +AA +
Sbjct: 176  LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK--NAYGITPLFVAAQS 233

Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
            G + A++ L   G+DIN Q   N  +AL  AC     EVV  LL + A+     K GL P
Sbjct: 234  GQLEALRFLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLP 292

Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
            L  A+  G   + ++LL      +   +  S  + L +AA++ H +  E L+   A  DV
Sbjct: 293  LHIASKKGNYRIVQMLLPV---TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDV 347

Query: 1321 R-----------NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
                          + ++ L+ A    +    +LL+Q GAD    +   I+PL+ A R G
Sbjct: 348  NTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHG 404

Query: 1370 HVKVVQYLV 1378
             ++ +Q L+
Sbjct: 405  CLRTMQLLL 413



 Score =  111 bits (277), Expect = 1e-23
 Identities = 117/404 (28%), Positives = 177/404 (43%), Gaps = 26/404 (6%)

Query: 964  PQIAITGHDQGLLVQEPDGLMVAT---PAQTLTDTLDDLIA-AVSTRVPTGSNSSSQTTE 1019
            P  A  G  QG++ +    L   +   PA  L   + D    A+ T +  G N +    E
Sbjct: 30   PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE 89

Query: 1020 CLTPESCSQTTSNVAS-QSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARD 1078
               P   +     V   + +   YP   ID  T    +TA+ LA   GH + +  L+   
Sbjct: 90   GWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAG 147

Query: 1079 AKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVV 1138
            A+ +  +K   TPL  A    +   V+IL+    D   +  R   T L  + S    EV+
Sbjct: 148  AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVM 206

Query: 1139 DLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 1198
             +L++ GA  E +N    TPL +AA  G +  ++ L   GA+IN++       S L  A 
Sbjct: 207  QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASD--NASALYEAC 264

Query: 1199 MNGHVPAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKT 1256
             N H   V+ LL  G+D N   +TN++  L L  A  +G   +V +LL   +    R ++
Sbjct: 265  KNEHEEVVEFLLSQGADAN---KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RS 320

Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP-------SSRDTALTIAADKGHYKFCE 1309
            G++PL  AA   + EV   LL    DVN P  P         R +AL  A    +    E
Sbjct: 321  GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380

Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
            LL+  GA     N+   +PL +A   G    +QLL+  GA++DA
Sbjct: 381  LLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421



 Score =  100 bits (250), Expect = 1e-20
 Identities = 76/255 (29%), Positives = 119/255 (46%), Gaps = 6/255 (2%)

Query: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 1183
            PL  A   G +E +  ++  G N    N   + PL  AA  G V  +K+L  A    I+ 
Sbjct: 60   PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119

Query: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
            RT  +   + + LA   GH+  +  LL  G++ +     +R T L  AC +  AE V +L
Sbjct: 120  RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176

Query: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
            +   A+  HR   G T L E+ S    EV ++L+  GA V +        T L +AA  G
Sbjct: 177  VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI--TPLFVAAQSG 234

Query: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
              +    L   GA I+ +     + L+ A    H +VV+ L+  GAD +  +   + PL 
Sbjct: 235  QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294

Query: 1364 SAFRKGHVKVVQYLV 1378
             A +KG+ ++VQ L+
Sbjct: 295  IASKKGNYRIVQMLL 309



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 57/186 (30%), Positives = 94/186 (50%), Gaps = 17/186 (9%)

Query: 1048 DAHTE-SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
            D +T+ S++ +AL  AC   HEE+V  L+++ A     +K G  PL +A+  G+  +V++
Sbjct: 248  DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307

Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG-------ANKEHRNVSDY--T 1157
            LL        +  R+  +PL LA      EV++ LL+         A +  R   D   +
Sbjct: 308  LLPVTS--RTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSS 365

Query: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
             L  A     V   ++LL  GA+ N        ISPL++A  +G +  ++LLLD G++I+
Sbjct: 366  ALYFAVVNNNVYATELLLQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANID 420

Query: 1218 AQIETN 1223
            A I T+
Sbjct: 421  AYIATH 426



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 35/208 (16%)

Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGAN------------------------------- 560
           +L  + PL++A ++G  E +K ++  G N                               
Sbjct: 54  QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113

Query: 561 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
              +   T   +TA+  A   GH D    LLQAGA+ +  ++   TPL KA    +   V
Sbjct: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173

Query: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677
           + L+   A+ N    N   T +  + +   L V+++L++ GA    +   G T L  AA+
Sbjct: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232

Query: 678 GGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
            G    + +L  Y  ++ +  + + S L
Sbjct: 233 SGQLEALRFLAKYGADINTQASDNASAL 260


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,373,912
Number of Sequences: 37866
Number of extensions: 5548785
Number of successful extensions: 89004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1107
Number of HSP's successfully gapped in prelim test: 1428
Number of HSP's that attempted gapping in prelim test: 33966
Number of HSP's gapped (non-prelim): 28798
length of query: 2542
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2423
effective length of database: 13,741,464
effective search space: 33295567272
effective search space used: 33295567272
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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