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Search of human proteins with 46519147
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
(2542 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 5035 0.0
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 4990 0.0
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 2855 0.0
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 1518 0.0
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 1167 0.0
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 1138 0.0
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 257 9e-68
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 237 1e-61
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 237 1e-61
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 237 1e-61
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 226 2e-58
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 226 2e-58
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 226 2e-58
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 226 2e-58
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 226 2e-58
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 225 5e-58
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 184 1e-45
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 180 2e-44
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 169 4e-41
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 168 7e-41
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 167 1e-40
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 164 8e-40
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 162 5e-39
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 159 3e-38
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 158 6e-38
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 158 6e-38
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled... 149 4e-35
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled... 149 4e-35
gi|67906195 ankyrin repeat and sterile alpha motif domain contai... 148 6e-35
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 140 2e-32
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 5035 bits (13061), Expect = 0.0
Identities = 2542/2542 (100%), Positives = 2542/2542 (100%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD
Sbjct: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT
Sbjct: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
Query: 721 HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE
Sbjct: 721 HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
Query: 781 ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK
Sbjct: 781 ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
Query: 841 VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD
Sbjct: 841 VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
Query: 901 TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI
Sbjct: 901 TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
Query: 961 VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC
Sbjct: 961 VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
Query: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK
Sbjct: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Query: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS
Sbjct: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
Query: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ
Sbjct: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
Query: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI
Sbjct: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
Query: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV
Sbjct: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
Query: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP
Sbjct: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
Query: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE
Sbjct: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
Query: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA
Sbjct: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
Query: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA
Sbjct: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
Query: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV
Sbjct: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
Query: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT
Sbjct: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
Query: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN
Sbjct: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
Query: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS
Sbjct: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
Query: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF
Sbjct: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
Query: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS
Sbjct: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
Query: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST
Sbjct: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
Query: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS
Sbjct: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
Query: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI
Sbjct: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
Query: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA
Sbjct: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
Query: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD
Sbjct: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
Query: 2521 AQQIWPGTWAPHIGNMHLKYVN 2542
AQQIWPGTWAPHIGNMHLKYVN
Sbjct: 2521 AQQIWPGTWAPHIGNMHLKYVN 2542
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 4990 bits (12943), Expect = 0.0
Identities = 2523/2523 (100%), Positives = 2523/2523 (100%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD
Sbjct: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT
Sbjct: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPT 720
Query: 721 HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE
Sbjct: 721 HTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVE 780
Query: 781 ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK
Sbjct: 781 ETEGKLNELGQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQK 840
Query: 841 VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD
Sbjct: 841 VERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELPQVD 900
Query: 901 TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI
Sbjct: 901 TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQI 960
Query: 961 VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC
Sbjct: 961 VGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTEC 1020
Query: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK
Sbjct: 1021 LTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAK 1080
Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Query: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS
Sbjct: 1381 VNQFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKS 1440
Query: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ
Sbjct: 1441 REESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQ 1500
Query: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI
Sbjct: 1501 EVPIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLI 1560
Query: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV
Sbjct: 1561 LPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELNFVMDV 1620
Query: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP
Sbjct: 1621 NSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSP 1680
Query: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE
Sbjct: 1681 KRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGE 1740
Query: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA
Sbjct: 1741 RMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTA 1800
Query: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA
Sbjct: 1801 ASSKNAFPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLA 1860
Query: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV
Sbjct: 1861 AQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTV 1920
Query: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT
Sbjct: 1921 LPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTSPPATVISSVT 1980
Query: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN
Sbjct: 1981 STCSSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMAN 2040
Query: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS
Sbjct: 2041 LCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNS 2100
Query: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF
Sbjct: 2101 EPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160
Query: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS
Sbjct: 2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSS 2220
Query: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST
Sbjct: 2221 QVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVST 2280
Query: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS
Sbjct: 2281 SPVGLPSIDPSGSSPSSSSAPLASFSGIPGTRVFLQGPAPVGTPSFNRQHFSPHPWTSAS 2340
Query: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI
Sbjct: 2341 NSSTSAPPTLGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGI 2400
Query: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA
Sbjct: 2401 WSFGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMA 2460
Query: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD
Sbjct: 2461 SGFVDFSKGLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
Query: 2521 AQQ 2523
AQQ
Sbjct: 2521 AQQ 2523
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 2855 bits (7402), Expect = 0.0
Identities = 1584/2576 (61%), Positives = 1867/2576 (72%), Gaps = 133/2576 (5%)
Query: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
Query: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
Query: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
Query: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
Query: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQ 753
+LS P DV+QL PPS D ++ PRVP L MVVPPQEPD+ + L K SKQ
Sbjct: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQ 782
Query: 754 KSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRI-SAIEK-AQLKSLELIQGEP 811
KSSS A+ + + Q E IVEE +GKL EL QRI AIEK AQL+SLEL +
Sbjct: 783 KSSSHLPANSQDVQGYITNQSPESIVEEAQGKLTELEQRIKEAIEKNAQLQSLELAHADQ 842
Query: 812 LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQ 871
L K+KIEEL K REEQ+QKK+KIL+ELQKVER+LQ+KTQQQ K+YLE K Q+ + Q
Sbjct: 843 LTKEKIEELNKTREEQIQKKQKILEELQKVERELQLKTQQQLKKQYLEVKAQRIQLQQQQ 902
Query: 872 Q--CSHRGVF-PEGEGDGSLPEDHFSELPQVDTILFKDNDVDDEQQSPPSAEQIDFVPVQ 928
Q C H G+ P G G+ L E ++ L QVD +L K D+ QQ +A Q+ F P+Q
Sbjct: 903 QQSCQHLGLLTPVGVGE-QLSEGDYARLQQVDPVLLK----DEPQQ---TAAQMGFAPIQ 954
Query: 929 PLSSPQC--NFSSDLGSNG-TNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMV 985
PL+ PQ + L N ELQ V Q ++GQ Q+A G QG+L + GLMV
Sbjct: 955 PLAMPQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLA--GLGQGILTETQQGLMV 1012
Query: 986 ATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQS-MPPVYPS 1044
A+PAQTL DTLDD++AAVS R SN+ + + + + T S + S S M P+YP+
Sbjct: 1013 ASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 1072
Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
+DIDA TESNHDTALTLACAGGHEELV L+ R A IEHRDKKGFTPLILAATAGHVGVV
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132
Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
EILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLLARGANKEHRNVSDYTPLSLAAS
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH AVKLLLDMGSDINAQIETNR
Sbjct: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
NTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
APPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRNKKGNTPLWLA+NGGH DVVQLL
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
VQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVNQFPSD ECMRYIATITDKE+LK
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLK 1432
Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKK 1464
KCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK REESR+ ALAAKREKRKEKR+KKK
Sbjct: 1433 KCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKK 1492
Query: 1465 EEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATF 1524
EEQ+RK EE E K KEN EL +++E+ + E EV EPPSATTTTTIGISAT T
Sbjct: 1493 EEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTL 1551
Query: 1525 TNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRG 1584
G KR N +TT S+ RKN+KNK TP +I + L + K+NGE +
Sbjct: 1552 AGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFDD---PLPISYSQPEKVNGESKS 1605
Query: 1585 GGAGGNSDSDNLDSTDCNSESSSGGKSQELN------FVMDVNSSKYPSLLLHSQEEKTS 1638
+ DSDN+ + C+ ESS+ S++ + V+S K PS+L+ +E+
Sbjct: 1606 SSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVVTTTVSSKKQPSVLVTFPKEERK 1665
Query: 1639 TATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVR 1695
+ + K +L E T NSLST K+ PLSSPN KL + SPKRGQKREEGWKEVVR
Sbjct: 1666 SVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNGKLTVASPKRGQKREEGWKEVVR 1725
Query: 1696 RSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGERMITIRGGTESTRYA 1755
RSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DKQKDK G+R+ITIRGGTESTR A
Sbjct: 1726 RSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDKQKDKTGDRIITIRGGTESTRQA 1785
Query: 1756 VQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSKNAFPLGAPTLV 1815
QLINALI+DP KE+++LIPKN ++ + S ++ S TT A++ + + T+
Sbjct: 1786 TQLINALIKDPDKEIDELIPKNRLK----SSSANSKIGSSAPTTTAANTSLMGIKMTTVA 1841
Query: 1816 ---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPVSLPLAYPHPHF--ALLAAQTMQ 1865
TSQ T T +K KN NVR FPVSLPLAYP P F ALLAAQT Q
Sbjct: 1842 LSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALLAAQTFQ 1901
Query: 1866 QIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVLPSES 1925
QIR PRLPM FGGTF P+ +TWGPFPVRP++P +SPK + R NQN + S
Sbjct: 1902 QIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQVNS 1961
Query: 1926 AGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLFACVPKTS-PPATVISSVTSTCS 1984
AG T+S T SS + + + SVR+QLF V KTS T +++ S +
Sbjct: 1962 AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNNN 2021
Query: 1985 SLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPM 2038
+ P+ ++ P+ + + +P++ P + + ++ SA P KV++ +
Sbjct: 2022 TAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASP---NKVASSSEQE 2078
Query: 2039 ANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSM---- 2094
A T N+ ++S++ G+ H S+ P S +QE P S + P +
Sbjct: 2079 AGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTV 2137
Query: 2095 -PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQ-------PRGSFYSM 2146
P A++S P + T+P T +PQ + P+ + +M+ P G+
Sbjct: 2138 PPLATSSAPVAVPSTAP--------VTYPMPQTPMGCPQPTPKMETPAIRPPPHGTTAPH 2189
Query: 2147 VPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMHINPANKSLPPTFGP 2206
+A++ ++ N + P P++VQL S ++ + Q ++PANK + P F
Sbjct: 2190 KNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSA 2247
Query: 2207 ATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFTVQSAFLGNSVLGHLENMHPDNS 2266
F FS+LF++S A+ WG +SS+ ++ + +S++L NS H D S
Sbjct: 2248 PLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLSGKSSYLPNSDPLH----QSDTS 2303
Query: 2267 KAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLASF-SGIPGTRVFLQGPAPVGTP- 2324
KAPGFRPP QR + SP G+ ++D S + SS L +F S I G +++ G G P
Sbjct: 2304 KAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASNISGGQMYGPGAPLGGAPA 2363
Query: 2325 --SFNRQHFSP----HPWTSASNSSTS------------APPT--LGQPKGVSASQDRKI 2364
+FNRQHFSP P +SASN S++ AP + LG K + SQDRK+
Sbjct: 2364 AANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPSPAPSSVPLGSEKPSNVSQDRKV 2423
Query: 2365 PPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWSFGVNAVSEGLSGWSQSVMGNHP 2424
P PIGTER ARIRQ G+ A + G++ VGHSGIWSF ++ W MGN
Sbjct: 2424 PVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWSFEGIGGNQDKVDWCNPGMGNPM 2483
Query: 2425 MHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASGFVDFSK--GLPISMYGGTIIPS 2482
+H+ +SDP FSQHQ MERD +G+V PS FHQ + +G++DF K G+P S+YG +IP
Sbjct: 2484 IHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAGYMDFPKVGGMPFSVYGNAMIPP 2543
Query: 2483 HPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTDAQQIWPGTWAPHIGNMHL 2538
+ D GGP+FNG H DP+WN +IK++ +STE Q +W G WAPH+ ++H+
Sbjct: 2544 VAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNGPQTVWTGPWAPHMNSVHM 2599
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 1518 bits (3930), Expect = 0.0
Identities = 869/1638 (53%), Positives = 1080/1638 (65%), Gaps = 97/1638 (5%)
Query: 964 PQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTP 1023
P++ + + QEPD P + TL AVS R SN+ + +
Sbjct: 745 PRVPVQALPMVVPPQEPD-----KPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASIS 799
Query: 1024 ESCSQTTSNVASQS-MPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIE 1082
+ + T S + S S M P+YP++DIDA TESNHDTALTLACAGGHEELV L+ R A IE
Sbjct: 800 QPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIE 859
Query: 1083 HRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL 1142
HRDKKGFTPLILAATAGHVGVVEILLD G DIEAQSERTKDTPLSLACSGGRQEVV+LLL
Sbjct: 860 HRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
Query: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH
Sbjct: 920 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 979
Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
AVKLLLDMGSDINAQIETNRNTALTLACFQGR EVVSLLLDRKANVEHRAKTGLTPLM
Sbjct: 980 TAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLM 1039
Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI RGAHIDVRN
Sbjct: 1040 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRN 1099
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVN 1382
KKGNTPLWLA+NGGH DVVQLLVQAGADVDAADNRKITPLM+AFRKGHVKVV+YLVKEVN
Sbjct: 1100 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1159
Query: 1383 QFPSDIECMRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSRE 1442
QFPSD ECMRYIATITDKE+LKKCH C+E+IV+AKD+QAAEANKNASILL+ELDLEK RE
Sbjct: 1160 QFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLEKLRE 1219
Query: 1443 ESRKQALAAKREKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDVEQEV 1502
ESR+ ALAAKREKRKEKR+KKKEEQ+RK EE E K KEN EL +++E+ + E EV
Sbjct: 1220 ESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEA-KNKENFELQAAQEKEKLKVEDEPEV 1278
Query: 1503 PIEPPSATTTTTIGISATSATFTNVFGKKRANVVTTPSTNRKNKKNKTKETPPTAHLILP 1562
EPPSATTTTTIGISAT T G KR N +TT S+ RKN+KNK TP +I
Sbjct: 1279 LTEPPSATTTTTIGISATWTTLAGSHG-KRNNTITTTSSKRKNRKNKI--TPENVQIIFD 1335
Query: 1563 EQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDCNSESSSGGKSQELN------F 1616
+ L + K+NGE + + DSDN+ + C+ ESS+ S++ +
Sbjct: 1336 D---PLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVV 1392
Query: 1617 VMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLE---GEVTPNSLSTSYKTVSLPLSSPNI 1673
V+S K PS+L+ +E+ + + K +L E T NSLST K+ PLSSPN
Sbjct: 1393 TTTVSSKKQPSVLVTFPKEERKSVSGKASIKLSETISEGTSNSLSTCTKSGPSPLSSPNG 1452
Query: 1674 KLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDK 1733
KL + SPKRGQKREEGWKEVVRRSKK+SVP++V+SR++GRGGCNI AI++ TGAHID+DK
Sbjct: 1453 KLTVASPKRGQKREEGWKEVVRRSKKVSVPSTVISRVIGRGGCNINAIREFTGAHIDIDK 1512
Query: 1734 QKDKNGERMITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFS 1793
QKDK G+R+ITIRGGTESTR A QLINALI+DP KE+++LIPKN ++ + S ++
Sbjct: 1513 QKDKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLK----SSSANSKIG 1568
Query: 1794 SGVGTTAASSKNAFPLGAPTLV---TSQATTLSTF-----QPANKLNKNVPTNVRSSFPV 1845
S TT A++ + + T+ TSQ T T +K KN NVR FPV
Sbjct: 1569 SSAPTTTAANTSLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPV 1628
Query: 1846 SLPLAYPHPHF--ALLAAQTMQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNS 1903
SLPLAYP P F ALLAAQT QQIR PRLPM FGGTF P+ +TWGPFPVRP++P +
Sbjct: 1629 SLPLAYPPPQFAHALLAAQTFQQIRPPRLPMTHFGGTFPPAQSTWGPFPVRPLSPARATN 1688
Query: 1904 SPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVRKQLF 1963
SPK + R NQN + SAG T+S T SS + + + SVR+QLF
Sbjct: 1689 SPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLF 1748
Query: 1964 ACVPKTS-PPATVISSVTSTCSSLPSVSSAPITSGQ------APTTFLPASTSQAQLSSQ 2016
V KTS T +++ S ++ P+ ++ P+ + + +P++ P + +
Sbjct: 1749 VTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNS 1808
Query: 2017 KMESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSN 2076
++ SA P KV++ + A T N+ ++S++ G+ H S+ P S
Sbjct: 1809 PLDCGSASP---NKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSSSAH-SNQQQPPGSV 1864
Query: 2077 TQEEAQPSSVSDLSPMSM-----PFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAP 2131
+QE P S + P + P A++S P + T+P T +PQ + P
Sbjct: 1865 SQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAP--------VTYPMPQTPMGCP 1916
Query: 2132 RVSHRMQ-------PRGSFYSMVPNATIHQDPQSIFVTNPVTLTPPQGPPAAVQLSSAVN 2184
+ + +M+ P G+ +A++ ++ N + P P++VQL S ++
Sbjct: 1917 QPTPKMETPAIRPPPHGTTAPHKNSASVQNSSVAVLSVNHI--KRPHSVPSSVQLPSTLS 1974
Query: 2185 IMNGSQMHINPANKSLPPTFGPATLFNHFSSLFDSSQVPANQGWGDGPLSSRVATDASFT 2244
+ Q ++PANK + P F F FS+LF++S A+ WG +SS+ ++ +
Sbjct: 1975 TQSACQNSVHPANKPIAPNFSAPLPFGPFSTLFENSPTSAHAFWGGSVVSSQSTPESMLS 2034
Query: 2245 VQSAFLGNSVLGHLENMHPDNSKAPGFRPPSQRVSTSPVGLPSIDPSGSSPSSSSAPLAS 2304
+S++L NS H D SKAPGFRPP QR + SP G+ ++D S + SS L +
Sbjct: 2035 GKSSYLPNSDPLH----QSDTSKAPGFRPPLQRPAPSPSGIVNMDSPYGSVTPSSTHLGN 2090
Query: 2305 F-SGIPGTRVFLQGPAPVGTP---SFNRQHFSP----HPWTSASNSSTS----------- 2345
F S I G +++ G G P +FNRQHFSP P +SASN S++
Sbjct: 2091 FASNISGGQMYGPGAPLGGAPAAANFNRQHFSPLSLLTPCSSASNDSSAQSVSSGVRAPS 2150
Query: 2346 -APPT--LGQPKGVSASQDRKIPPPIGTERLARIRQGGSVAQAPAGTSFVAPVGHSGIWS 2402
AP + LG K + SQDRK+P PIGTER ARIRQ G+ A + G++ VGHSGIWS
Sbjct: 2151 PAPSSVPLGSEKPSNVSQDRKVPVPIGTERSARIRQTGTSAPSVIGSNLSTSVGHSGIWS 2210
Query: 2403 FGVNAVSEGLSGWSQSVMGNHPMHQQLSDPSTFSQHQPMERDDSGMVAPSNIFHQPMASG 2462
F ++ W MGN +H+ +SDP FSQHQ MERD +G+V PS FHQ + +G
Sbjct: 2211 FEGIGGNQDKVDWCNPGMGNPMIHRPMSDPGVFSQHQAMERDSTGIVTPSGTFHQHVPAG 2270
Query: 2463 FVDFSK--GLPISMYGGTIIPSHPQLADVPGGPLFNGLHNPDPAWNPMIKVIQNSTECTD 2520
++DF K G+P S+YG +IP + D GGP+FNG H DP+WN +IK++ +STE
Sbjct: 2271 YMDFPKVGGMPFSVYGNAMIPPVAPIPDGAGGPIFNGPHAADPSWNSLIKMVSSSTENNG 2330
Query: 2521 AQQIWPGTWAPHIGNMHL 2538
Q +W G WAPH+ ++H+
Sbjct: 2331 PQTVWTGPWAPHMNSVHM 2348
Score = 1158 bits (2995), Expect = 0.0
Identities = 591/701 (84%), Positives = 633/701 (90%), Gaps = 23/701 (3%)
Query: 42 RTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDE-- 99
RT R + +S +SGGGG G G GGG GGG ++ S+E+E
Sbjct: 78 RTCRPPSSSESSSDSDNSGGGGGGGGGGGG---------------GGGTSSNNSEEEEDD 122
Query: 100 ------VSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAA 153
VSEVESFILDQ+DL+NP+L+T S++ LS TA+GADLRTVDPETQARLEALLEAA
Sbjct: 123 DDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLEAA 182
Query: 154 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEAC 213
GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRM+AE++ NAGQ D RSLAEAC
Sbjct: 183 GIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTANAGQSDNRSLAEAC 242
Query: 214 SDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDI 273
S+GDVNAVRKLL EGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG KGDI
Sbjct: 243 SEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDI 302
Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
TPLMAA++GG++ IVKLLL H ADVN+QS+TGNTALTYACAGG+VD+VKVLL GA+IED
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
HNENGHTPLMEA SAGHVEVAR+LL++GAGINTHSNEFKESALTLACYKGHL+MVRFLLE
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
AALLIERGA+LEEVNDEGYTPLMEAAREGHEEMVALLL QGANINAQTEETQETALTLAC
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 514 CGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
CGGF EVADFLIKAGADIELGCSTPLMEA+QEGHLELVKYLLA+GANVHATTATGDTALT
Sbjct: 543 CGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALT 602
Query: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH+CTVQFLISKGANVNR TAN
Sbjct: 603 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
Query: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
NDHTV+SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT+VV YLLDYPNN
Sbjct: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
Query: 694 VLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDR 734
+LS P DV+QL PPS D ++ PRVP L MVVPPQEPD+
Sbjct: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDK 763
Score = 213 bits (542), Expect = 2e-54
Identities = 138/365 (37%), Positives = 198/365 (54%), Gaps = 38/365 (10%)
Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
D++A + S +TALT ACAGG+ ++V VL+ A IE ++ G TPL+ A +AGHV V
Sbjct: 326 DVNAQS-STGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVAR 384
Query: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
+LL+ G I S K++ L+LAC G E+V LL GA++EH+ +T L A
Sbjct: 385 LLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMD 444
Query: 1166 GYVNIIKILLNAGAEINS-------------------------RTGSKL------GISPL 1194
G+V + ++LL++GA++N G+ L G +PL
Sbjct: 445 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL 504
Query: 1195 MLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA 1254
M AA GH V LLL G++INAQ E + TALTLAC G EV L+ A++E
Sbjct: 505 MEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGC 564
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
TPLMEAA G+ E+ + LL GA+V+A ++ DTALT A + GH ++L+
Sbjct: 565 S---TPLMEAAQEGHLELVKYLLAAGANVHA--TTATGDTALTYACENGHTDVADVLLQA 619
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD-AADNRKITPLMSAFRKGHVKV 1373
GA ++ ++ G TPL A+ GH VQ L+ GA+V+ N T L A GH+ V
Sbjct: 620 GADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAV 679
Query: 1374 VQYLV 1378
V+ L+
Sbjct: 680 VELLL 684
Score = 211 bits (538), Expect = 6e-54
Identities = 126/336 (37%), Positives = 194/336 (57%), Gaps = 10/336 (2%)
Query: 297 DVNSQSATGN-TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
D+++Q+ + + TALT ACAGG ++V+ LL GA+IE ++ G TPL+ AA+AGHV V
Sbjct: 823 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 882
Query: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
+LLD+GA I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 883 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 942
Query: 416 GHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEGY 472
G+V + ++LL++GA++N S SPL LAA GH LL++ G+++ ++
Sbjct: 943 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN 1002
Query: 473 TPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIE 532
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 1003 TALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
Query: 533 L-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
T L A+ +GH + + L+ GA++ G+T L A GH DV +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Query: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISK 623
+QAGAD++ TPLM A R GH+ V++L+ +
Sbjct: 1122 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 207 bits (526), Expect = 1e-52
Identities = 127/352 (36%), Positives = 195/352 (55%), Gaps = 35/352 (9%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
+L AC+ G V+ LL+ G S+ ++G + L LA +AG+ + ++LL A++E +
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
+ TPL A SGG ++V+LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 895 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
Query: 328 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 385
GA I ++ G +PLM AA GH ++LLD G+ IN + +ALTLAC++G
Sbjct: 955 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
Query: 386 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 443
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1074
Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
+AA GH + LLI RGA+++ N +G TPL AA GH ++V LL+ GA+++A
Sbjct: 1075 IAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNR 1134
Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
TPLM A ++GH+++V+YL+
Sbjct: 1135 K-------------------------------ITPLMAAFRKGHVKVVRYLV 1155
Score = 198 bits (503), Expect = 6e-50
Identities = 139/450 (30%), Positives = 232/450 (51%), Gaps = 16/450 (3%)
Query: 942 GSNGTNSLELQKVSGNQQIVGQPQIAITGHD--QGLLVQEPDGLMVATPA-----QTLTD 994
G++ NS E + ++ V + + I D + +++ L+++ A +T+
Sbjct: 110 GTSSNNSEEEEDDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDP 169
Query: 995 TLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESN 1054
+ A+ G S++ PE + TS+V+ + A + +N
Sbjct: 170 ETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMRAESTAN 229
Query: 1055 ----HDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
+ +L AC+ G V L+ + ++G + L LA +AG+ + ++LL
Sbjct: 230 AGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM 289
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
++E + + TPL A +GG ++V LLLA A+ ++ + T L+ A +GGYV++
Sbjct: 290 HANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDV 349
Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
+K+LL +GA I ++ G +PLM A GHV +LLL+ G+ IN + +ALTL
Sbjct: 350 VKVLLESGASIEDH--NENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL 407
Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
AC++G E+V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P
Sbjct: 408 ACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--AD 465
Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
S ++ LT+AA GH + LLI RGA ++ N +G TPL A+ GH ++V LL+ GA+
Sbjct: 466 SFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN 525
Query: 1351 VDA-ADNRKITPLMSAFRKGHVKVVQYLVK 1379
++A + + T L A G ++V +L+K
Sbjct: 526 INAQTEETQETALTLACCGGFLEVADFLIK 555
Score = 186 bits (473), Expect = 2e-46
Identities = 191/699 (27%), Positives = 304/699 (43%), Gaps = 108/699 (15%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGE-SLLCLACSAGYYELAQVLLAMHANVEDR 267
L +A G V V+ L+ +G +VN T + ++L LAC+ G+ + ++LLA A+ R
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALT-------YACAGGFVDI 320
G T L+ A+ GG+ +V LL + ++ S T LT A +
Sbjct: 694 LKDGS-TMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQAL 752
Query: 321 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 380
V+ + + N P+ A +G H + + + ++
Sbjct: 753 PMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIIS- 811
Query: 381 YKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
+ D + +T+ H TAL AC GH E+ + LL+ GA +
Sbjct: 812 -----PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF 866
Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGY-TPLMEAAREGHEEMVALLLAQGANIN 498
+PL LAA GHV + +L++ GA++E ++ TPL A G +E+V LLLA+GAN
Sbjct: 867 TPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGAN-K 925
Query: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADI------ELGCSTPLMEASQEGHLELVK 552
+ T L+LA GG+ + L+ AGA+I +LG S PLM A+ GH VK
Sbjct: 926 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-PLMLAAMNGHTAAVK 984
Query: 553 YLLASGANVHATTATG-DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
LL G++++A T +TALT AC G T+V +LL A++EH ++ G TPLM+AA
Sbjct: 985 LLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1044
Query: 612 GHLCTVQFLISKGANVN-------RATA---------------------------NNDHT 637
G+ + L+ KGA+VN R TA +T
Sbjct: 1045 GYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNT 1104
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697
+ LA GGHL VV+LL+ GAD T L+ A + GH VV YL+
Sbjct: 1105 PLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV--------- 1155
Query: 698 PTTDVSQLPPPSQDQSQVPRVPTHT------LAMVVPPQEPDRTSQENSPALLGVQKGTS 751
+V+Q P S+ + + L M Q DR + E
Sbjct: 1156 --KEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAE------------- 1200
Query: 752 KQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLNELGQRISAIEKAQLKSLELIQGEP 811
K++S+ + + DL KL E +R++ K + + + + +
Sbjct: 1201 ANKNASILLEELDL------------------EKLREESRRLALAAKREKRKEKRRKKKE 1242
Query: 812 LNKDKIEELKKNREEQVQKKKKILKELQKVERQLQMKTQ 850
+ K+EE++ +E + + KE KVE + ++ T+
Sbjct: 1243 EQRRKLEEIEAKNKENFELQAAQEKEKLKVEDEPEVLTE 1281
Score = 175 bits (443), Expect = 6e-43
Identities = 129/360 (35%), Positives = 192/360 (53%), Gaps = 20/360 (5%)
Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
+++ T +N T L+LACAGGH +V +L+A A HR K G T LI AA GH VV
Sbjct: 655 NVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Query: 1106 ILLDKGGDI--EAQSERTKDTP----LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
LLD ++ + T+ TP L+ A Q + ++ + +K NV+ P+
Sbjct: 715 YLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPI 774
Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGS-KLGISPLMLAAMNGHV-PAVKLLLDMGSDIN 1217
A G A A N+ T S IS + + P+ L + DI+
Sbjct: 775 RNKAVSG---------RASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825
Query: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
AQ E+N +TALTLAC G E+V LL+R A++EHR K G TPL+ AA+ G+ V +LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
D GAD+ A ++DT L++A G + ELL+ RGA+ + RN TPL LA++GG+
Sbjct: 886 DNGADIEAQS-ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 944
Query: 1338 FDVVQLLVQAGADVDAADNRK--ITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA 1395
+++++L+ AGA++++ K I+PLM A GH V+ L+ + + IE R A
Sbjct: 945 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA 1004
Score = 161 bits (407), Expect = 9e-39
Identities = 102/265 (38%), Positives = 144/265 (54%), Gaps = 34/265 (12%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
++ LTLA GGH EL ++LI R A +E + +G+TPL+ AA GH +V +LL +G +I
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
AQ+E T++T L+LAC GG EV D L+ GA+ E + TPL AA G++ ++K LL
Sbjct: 528 AQTEETQETALTLACCGGFLEVADFLIKAGADIE---LGCSTPLMEAAQEGHLELVKYLL 584
Query: 1176 NAGAEINSRTG-------------------------------SKLGISPLMLAAMNGHVP 1204
AGA +++ T S+ G +PLM AA GHV
Sbjct: 585 AAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVC 644
Query: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
V+ L+ G+++N N +T L+LAC G VV LLL A+ HR K G T L+EA
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 1265 ASGGYAEVGRVLLDKGADVNAPPVP 1289
A GG+ V LLD ++ + P P
Sbjct: 705 AKGGHTSVVCYLLDYPNNLLSAPPP 729
Score = 154 bits (388), Expect = 1e-36
Identities = 114/333 (34%), Positives = 161/333 (48%), Gaps = 11/333 (3%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T + DTALT AC GH ++ VL+ A +EH + G TPL+ AA AGHV V+ L+ K
Sbjct: 593 TTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISK 652
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
G ++ + T LSLAC+GG VV+LLLA GA+ HR T L AA GG+ ++
Sbjct: 653 GANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
+ LL+ + S + +N L M + N A TL
Sbjct: 713 VCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTL 772
Query: 1231 ----ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
GRA +S A + P S + + + D++A
Sbjct: 773 PIRNKAVSGRASAMS-----NTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA- 826
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
S+ DTALT+A GH + + L+ RGA I+ R+KKG TPL LA+ GH VV++L+
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 1347 AGADVDAADNR-KITPLMSAFRKGHVKVVQYLV 1378
GAD++A R K TPL A G +VV+ L+
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLL 919
Score = 72.0 bits (175), Expect = 7e-12
Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 6/165 (3%)
Query: 167 ADPEVLRRLTSSVSC--ALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKL 224
A E R +++C E + L KA H A + L EA S G R L
Sbjct: 995 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1053
Query: 225 LDEGRSVNEHT--EEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
LD+G VN ++ L +A G+Y+ ++L+ A+++ R KG+ TPL A++G
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGN-TPLWLAANG 1112
Query: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
G+LD+V+LL+ ADV++ T L A G V +V+ L+ E
Sbjct: 1113 GHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
Score = 33.1 bits (74), Expect = 3.6
Identities = 31/146 (21%), Positives = 55/146 (37%), Gaps = 18/146 (12%)
Query: 1542 NRKNKKNKTKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTDC 1601
+ K K+N+T P ++ + +D + G GGG GG S N +
Sbjct: 71 HHKAKRNRTCRPPSSSE----------SSSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEE 120
Query: 1602 NSESSSGGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATS--------KTQTRLEGEVT 1653
+ + S+ +F++D + + P L S+ + TA +TQ RLE +
Sbjct: 121 DDDDEEEEVSEVESFILDQDDLENPMLETASKLLLSGTADGADLRTVDPETQARLEALLE 180
Query: 1654 PNSLSTSYKTVSLPLSSPNIKLNLTS 1679
+ + P + LTS
Sbjct: 181 AAGIGKLSTADGKAFADPEVLRRLTS 206
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 1167 bits (3020), Expect = 0.0
Identities = 601/619 (97%), Positives = 604/619 (97%), Gaps = 1/619 (0%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 599
Query: 601 GRTPLMKAARAGHLCTVQF 619
+T L A H V F
Sbjct: 600 MKTILEGIDPAKHQVRVAF 618
Score = 248 bits (632), Expect = 7e-65
Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)
Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
L EA S G V R LLD G +N H+ E ES L LAC G+ ++ + LL A+ E +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 267
Query: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
GAN+E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G ++
Sbjct: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
FL++AGAD E T LMEA +GH+E+ + LL SGA V+ + ++ LT A
Sbjct: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
++LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL NV +
Sbjct: 508 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 563
Query: 697 VPTT 700
T
Sbjct: 564 TTAT 567
Score = 202 bits (514), Expect = 3e-51
Identities = 146/438 (33%), Positives = 228/438 (52%), Gaps = 49/438 (11%)
Query: 981 DGLMVATP------AQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA 1034
DG A P +++ LD+ AA++ S+++ Q E+CS N
Sbjct: 162 DGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAV 221
Query: 1035 SQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG-FTPLI 1093
+ + ++ HTE ++ L LAC+ G+ EL VL+A A +E R KG TPL+
Sbjct: 222 RKLLDE---GRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLM 277
Query: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153
A++ G++ +V++LL D+ +QS T +T L+ AC+GG ++V +LL GAN E N
Sbjct: 278 AASSGGYLDIVKLLLLHDADVNSQSA-TGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTG----SKLGIS----------------- 1192
+ +TPL AAS G+V + ++LL+ GA IN+ + S L ++
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
Query: 1193 -----------PLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
LM A M+GHV +LLLD G+ +N ++ + LTLA G E+ +
Sbjct: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP-LTLAACGGHVELAA 455
Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
LL++R AN+E G TPLMEAA G+ E+ +LL +GA++NA +++TALT+A
Sbjct: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ-TEETQETALTLACC 514
Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
G + + LI GA I++ +TPL AS GH ++V+ L+ +GA+V A T
Sbjct: 515 GGFSEVADFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGDTA 571
Query: 1362 LMSAFRKGHVKVVQYLVK 1379
L A GH V L++
Sbjct: 572 LTYACENGHTDVADVLLQ 589
Score = 201 bits (512), Expect = 6e-51
Identities = 146/475 (30%), Positives = 238/475 (50%), Gaps = 48/475 (10%)
Query: 942 GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
G++G++ E+ +V +Q+ + P + T + L +G + T L+
Sbjct: 91 GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
Query: 999 LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVA---SQSMPPVYPSVDIDAHTESNH 1055
L+ A G S++ PE + TS+V+ ++ + ++H
Sbjct: 149 LLEAAGI----GKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
Query: 1056 DT-ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDI 1114
DT +L AC+ G V L+ + ++G + L LA +AG+ + ++LL ++
Sbjct: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
E + + TPL A SGG ++V LLL A+ ++ + T L+ A +GG+V+I+K+L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
LN GA I ++ G +PLM AA GHV ++LLD G+ IN + +ALTLAC++
Sbjct: 325 LNEGANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1294
G ++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFES 440
Query: 1295 ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAA 1354
LT+AA GH + LLI RGA+++ N +G TPL A+ GH ++V LL+ GA+++A
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 1355 DNRK-------------------------------ITPLMSAFRKGHVKVVQYLV 1378
TPLM A ++GH+++V+YL+
Sbjct: 501 TEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
Score = 191 bits (486), Expect = 6e-48
Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)
Query: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
D D +++S +TALT ACAGG ++V VL+ A IE ++ G TPL+ AA+AGHV V
Sbjct: 295 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 354
Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
+LLD G I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 355 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
G+V + ++LL++GA++N S SPL LAA GHV LL++ G+++ ++
Sbjct: 415 DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 471
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
T L A+ +GH + + L+ GA++ G+T L A GH DV +
Sbjct: 532 EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
Query: 1344 LVQAGADVDAADNRK 1358
L+QAGAD+D ++ K
Sbjct: 587 LLQAGADLDKQEDMK 601
Score = 167 bits (423), Expect = 1e-40
Identities = 99/248 (39%), Positives = 136/248 (54%), Gaps = 5/248 (2%)
Query: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
+C AAL + N L EA +G V LL +G ++N TEE
Sbjct: 180 SCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG- 238
Query: 506 ETALTLACCGGFSEVADFLIKAGADIE----LGCSTPLMEASQEGHLELVKYLLASGANV 561
E+ L LAC G+ E+A L+ A++E G TPLM AS G+L++VK LL A+V
Sbjct: 239 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 298
Query: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
++ +ATG+TALTYAC G D+ VLL GA++E +E G TPLM+AA AGH+ + L+
Sbjct: 299 NSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLL 358
Query: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
GA +N + + ++LAC GHL +V LL GAD H+ + T L+EA GH
Sbjct: 359 DHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
Query: 682 NVVSYLLD 689
V LLD
Sbjct: 419 EVARLLLD 426
Score = 155 bits (391), Expect = 6e-37
Identities = 102/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)
Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
L+ ACS G V LL G + + L LA S GY + ++LL A + R
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 267
Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
G+K I+PLM A+ G++ VKLLL +D+N+Q T NTALT AC G ++V +LL+
Sbjct: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 326
Query: 1246 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305
AN+E + G TPLMEAAS G+ EV RVLLD GA +N +++ALT+A KGH
Sbjct: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 385
Query: 1306 ---------------------------------KFCELLIHRGAHIDVRNKKGNTPLWLA 1332
+ LL+ GA +++ +PL LA
Sbjct: 386 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 445
Query: 1333 SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
+ GGH ++ LL++ GA+++ ++ TPLM A R+GH ++V L+ +
Sbjct: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Score = 75.1 bits (183), Expect = 8e-13
Identities = 59/205 (28%), Positives = 90/205 (43%), Gaps = 5/205 (2%)
Query: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL--GCSTPLMEASQEGHLE 549
A+GA++ ETQ L G +++ KA AD E+ ++ + A E
Sbjct: 130 AEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAA 189
Query: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
L + N H +L AC +G + LL G + +E G + L A
Sbjct: 190 LTRM---KAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLAC 246
Query: 610 RAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
AG+ Q L++ ANV D T + A +GG+L +V+LLL H AD + G+
Sbjct: 247 SAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
Query: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
T L A GG ++V LL+ N+
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANI 331
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 1138 bits (2943), Expect = 0.0
Identities = 590/619 (95%), Positives = 593/619 (95%), Gaps = 12/619 (1%)
Query: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG
Sbjct: 1 MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSG 60
Query: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT
Sbjct: 61 GGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKT 120
Query: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVS 180
TSEIFLSSTAEGADLRTVDPETQARLEALLEAA AFADPEVLRRLTSSVS
Sbjct: 121 TSEIFLSSTAEGADLRTVDPETQARLEALLEAA-----------AFADPEVLRRLTSSVS 169
Query: 181 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 240
CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES
Sbjct: 170 CALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGES 229
Query: 241 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 300
LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS
Sbjct: 230 LLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNS 289
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH
Sbjct: 290 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
Query: 361 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 420
GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV
Sbjct: 350 GAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEV 409
Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR
Sbjct: 410 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 469
Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 540
EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM
Sbjct: 470 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLM 529
Query: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADL+ + E
Sbjct: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD-KQED 588
Query: 601 GRTPLMKAARAGHLCTVQF 619
+T L A H V F
Sbjct: 589 MKTILEGIDPAKHQVRVAF 607
Score = 248 bits (632), Expect = 7e-65
Identities = 149/364 (40%), Positives = 216/364 (59%), Gaps = 10/364 (2%)
Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
L EA S G V R LLD G +N H+ E ES L LAC G+ ++ + LL A+ E +
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEE-GESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 402 TDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
++ T LM A G++++ +LLL A VN + + + LT A GG V++ +L+
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
GAN+E+ N+ G+TPLMEAA GH E+ +LL GA IN + E +E+ALTLAC G ++
Sbjct: 317 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 376
Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
FL++AGAD E T LMEA +GH+E+ + LL SGA V+ + ++ LT A
Sbjct: 377 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 436
Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
GH ++A +L++ GA+LE ++ G TPLM+AAR GH V L+++GAN+N T T
Sbjct: 437 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDG-STMLIEAAKGGHTNVVSYLLDYPNNVLS 696
++LAC GG V + L+ GAD ++ G ST L+EA++ GH +V YLL NV +
Sbjct: 497 ALTLACCGGFSEVADFLIKAGAD----IELGCSTPLMEASQEGHLELVKYLLASGANVHA 552
Query: 697 VPTT 700
T
Sbjct: 553 TTAT 556
Score = 204 bits (518), Expect = 1e-51
Identities = 145/472 (30%), Positives = 232/472 (49%), Gaps = 53/472 (11%)
Query: 942 GSNGTNSLELQKVSG---NQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDD 998
G++G++ E+ +V +Q+ + P + T + L +G + T L+
Sbjct: 91 GASGSDEDEVSEVESFILDQEDLDNPVLKTTS--EIFLSSTAEGADLRTVDPETQARLEA 148
Query: 999 LIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDT- 1057
L+ A + P + + C E+ + T A S H DT
Sbjct: 149 LLEAAAFADPEVLRRLTSSVSCALDEAAAALTRMKAENS------------HNAGQVDTR 196
Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
+L AC+ G V L+ + ++G + L LA +AG+ + ++LL ++E +
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 256
Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
+ TPL A SGG ++V LLL A+ ++ + T L+ A +GG+V+I+K+LLN
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 316
Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
GA I ++ G +PLM AA GHV ++LLD G+ IN + +ALTLAC++G
Sbjct: 317 GANIEDH--NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHL 374
Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
++V LL+ A+ EH+ T LMEA G+ EV R+LLD GA VN P S ++ LT
Sbjct: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLT 432
Query: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
+AA GH + LLI RGA+++ N +G TPL A+ GH ++V LL+ GA+++A
Sbjct: 433 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 492
Query: 1358 K-------------------------------ITPLMSAFRKGHVKVVQYLV 1378
TPLM A ++GH+++V+YL+
Sbjct: 493 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 544
Score = 202 bits (513), Expect = 4e-51
Identities = 142/417 (34%), Positives = 221/417 (52%), Gaps = 43/417 (10%)
Query: 996 LDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNH 1055
LD+ AA++ S+++ Q E+CS N + + ++ HTE
Sbjct: 172 LDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDE---GRSVNEHTEEG- 227
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKG-FTPLILAATAGHVGVVEILLDKGGDI 1114
++ L LAC+ G+ EL VL+A A +E R KG TPL+ A++ G++ +V++LL D+
Sbjct: 228 ESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADV 287
Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
+QS T +T L+ AC+GG ++V +LL GAN E N + +TPL AAS G+V + ++L
Sbjct: 288 NSQSA-TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVL 346
Query: 1175 LNAGAEINSRTG----SKLGIS----------------------------PLMLAAMNGH 1202
L+ GA IN+ + S L ++ LM A M+GH
Sbjct: 347 LDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 406
Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
V +LLLD G+ +N ++ + LTLA G E+ +LL++R AN+E G TPLM
Sbjct: 407 VEVARLLLDSGAQVNMPADSFESP-LTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
EAA G+ E+ +LL +GA++NA +++TALT+A G + + LI GA I++
Sbjct: 466 EAAREGHEEMVALLLAQGANINAQ-TEETQETALTLACCGGFSEVADFLIKAGADIELGC 524
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
+TPL AS GH ++V+ L+ +GA+V A T L A GH V L++
Sbjct: 525 ---STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
Score = 191 bits (486), Expect = 6e-48
Identities = 118/315 (37%), Positives = 178/315 (56%), Gaps = 10/315 (3%)
Query: 1046 DIDAHTES-NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
D D +++S +TALT ACAGG ++V VL+ A IE ++ G TPL+ AA+AGHV V
Sbjct: 284 DADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVA 343
Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
+LLD G I S K++ L+LAC G ++V LL GA++EH+ +T L A
Sbjct: 344 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 403
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
G+V + ++LL++GA++N S SPL LAA GHV LL++ G+++ ++
Sbjct: 404 DGHVEVARLLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLE-EVNDEG 460
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
T L A +G E+V+LLL + AN+ + +T T L A GG++EV L+ GAD+
Sbjct: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
T L A+ +GH + + L+ GA++ G+T L A GH DV +
Sbjct: 521 EL-----GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 575
Query: 1344 LVQAGADVDAADNRK 1358
L+QAGAD+D ++ K
Sbjct: 576 LLQAGADLDKQEDMK 590
Score = 168 bits (425), Expect = 7e-41
Identities = 108/286 (37%), Positives = 146/286 (51%), Gaps = 22/286 (7%)
Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
AL+EA EV R L S +C AAL + N
Sbjct: 148 ALLEAAAFADPEVLRRLTSS-----------------VSCALDEAAAALTRMKAENSHNA 190
Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
L EA +G V LL +G ++N TEE E+ L LAC G+ E+A L+
Sbjct: 191 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG-ESLLCLACSAGYYELAQVLLAM 249
Query: 528 GADIE----LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583
A++E G TPLM AS G+L++VK LL A+V++ +ATG+TALTYAC G D+
Sbjct: 250 HANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDI 309
Query: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
VLL GA++E +E G TPLM+AA AGH+ + L+ GA +N + + ++LAC
Sbjct: 310 VKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLAC 369
Query: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
GHL +V LL GAD H+ + T L+EA GH V LLD
Sbjct: 370 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 415
Score = 155 bits (391), Expect = 6e-37
Identities = 102/288 (35%), Positives = 150/288 (52%), Gaps = 36/288 (12%)
Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
L+ ACS G V LL G + + L LA S GY + ++LL A + R
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR- 256
Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
G+K I+PLM A+ G++ VKLLL +D+N+Q T NTALT AC G ++V +LL+
Sbjct: 257 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG-NTALTYACAGGFVDIVKVLLN 315
Query: 1246 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1305
AN+E + G TPLMEAAS G+ EV RVLLD GA +N +++ALT+A KGH
Sbjct: 316 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS-NEFKESALTLACYKGHL 374
Query: 1306 ---------------------------------KFCELLIHRGAHIDVRNKKGNTPLWLA 1332
+ LL+ GA +++ +PL LA
Sbjct: 375 DMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLA 434
Query: 1333 SNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
+ GGH ++ LL++ GA+++ ++ TPLM A R+GH ++V L+ +
Sbjct: 435 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Score = 69.7 bits (169), Expect = 3e-11
Identities = 43/135 (31%), Positives = 63/135 (46%)
Query: 560 NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQF 619
N H +L AC +G + LL G + +E G + L A AG+ Q
Sbjct: 186 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 245
Query: 620 LISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGG 679
L++ ANV D T + A +GG+L +V+LLL H AD + G+T L A GG
Sbjct: 246 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 305
Query: 680 HTNVVSYLLDYPNNV 694
++V LL+ N+
Sbjct: 306 FVDIVKVLLNEGANI 320
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 257 bits (657), Expect = 9e-68
Identities = 201/635 (31%), Positives = 289/635 (45%), Gaps = 79/635 (12%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L A G V L+ G ++N ++G + L A G+ E+ LL V D
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKV-DCA 640
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
+ T L AA+ GG+ DIV LL H A+VN G TAL A G +IV+ LL+ G
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 329 ANIEDHNENGHTPLMEAA-----SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
A + + +G T L AA S GH V +L+D GA ++ H ++ + L +A Y+G
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEG 759
Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH-------------------------- 417
H+D+V LLE GAD +H + T L+ A GH
Sbjct: 760 HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
Query: 418 -------VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
VEV R LLD G N D+ +PL +AA GH + LIE+GA E++++
Sbjct: 820 IASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDND 879
Query: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
G P + A++EGH + V +LL +NI+ + + + AL +A G ++ + L GAD
Sbjct: 880 GRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN-ALRVAALEGHRDIVELLFSHGAD 938
Query: 531 I---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
+ + L + E L + +Y L +GANV A+ A G TAL +C GH ++ VL
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647
+ AD+ R+ L AA GH+ VQ LI GA V+ T N T + +A GH
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH-TCNQGATALCIAAQEGH 1057
Query: 648 LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP----NNVLSVPTTDVS 703
+ VV++LL HGADP H + G T + AAK GH+ ++ L Y N P +
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTME 1117
Query: 704 QLPPPSQDQS------------------------QVPRVPTHTLAMVVPPQEPDRTSQEN 739
Q P S +P PTH A P + PD T
Sbjct: 1118 QKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTH--AFSSPSESPDSTVDRQ 1175
Query: 740 SPAL----LGVQKGTSKQKSSSLQVADQDLLPSFH 770
+L L K +S + +SS A + SFH
Sbjct: 1176 KSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFH 1210
Score = 234 bits (597), Expect = 8e-61
Identities = 164/513 (31%), Positives = 252/513 (49%), Gaps = 45/513 (8%)
Query: 219 NAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMA 278
+++R LLD G SVN+ G +LL A +G ++ +L++ A++E G TPL
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH-TPLTL 584
Query: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
A+ G+ +V L+ A++N G TAL A GG ++V LL G ++ + +
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 339 HTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQ 398
T L AA GH ++ LL HGA +N NE + +AL A Y GH ++V LL+ GA+
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGR-TALIAAAYMGHREIVEHLLDHGAEV 703
Query: 399 EHKTDEMHTALMEACM-----DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
H+ + TAL A + GH V LL+D GA+V+ +PL +AA GHV++
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDV 763
Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
LL+E GA+++ ++ G TPL+ AA GH +V LL GA +++ E + T L++A
Sbjct: 764 VDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-TVLSIAS 822
Query: 514 CGGFSEVADFLIKAGAD---------------------------IELGCST--------- 537
G EV L+ G D IE G T
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
P + ASQEGH + V+ LL + +N+ G AL A GH D+ ++L GAD+ +
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
GR L A L ++ + GANV + A T + ++C GH+ +V++L+A+
Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEASDAEG-RTALHVSCWQGHMEMVQVLIAY 1001
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
AD + + L AA GH VV L+++
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034
Score = 215 bits (548), Expect = 4e-55
Identities = 147/480 (30%), Positives = 235/480 (48%), Gaps = 42/480 (8%)
Query: 200 NAGQVDTRSLAEACS-DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
+ D+R+ A + G + V LL G VN+ EG + L A G+ E+ + LL
Sbjct: 638 DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLL 697
Query: 259 AMHANVEDRGNKG----DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACA 314
A V G + L +S G+ +V LL+ A+V+ G T L A
Sbjct: 698 DHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY 757
Query: 315 GGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
G VD+V +LL GA+++ + NG TPL+ AAS GH V LL GA +++ +E + +
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR-T 816
Query: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMP 434
L++A +G++++VR LL+ G D+ H+ D T L A +GH + L++ GA+ N
Sbjct: 817 VLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEI 876
Query: 435 ADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQG 494
+ P LA+ GH + +L+E +N+++ +G L AA EGH ++V LL + G
Sbjct: 877 DNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHG 936
Query: 495 ANINAQTEETQ--------------------------------ETALTLACCGGFSEVAD 522
A++N + + + TAL ++C G E+
Sbjct: 937 ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQ 996
Query: 523 FLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
LI AD+ + + L A+ +GH+++V+ L+ GA V T G TAL A + G
Sbjct: 997 VLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEG 1056
Query: 580 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGA-NVNRATANNDHTV 638
H DV VLL+ GAD H + GRT + AA+ GH ++ L GA ++N + + HT+
Sbjct: 1057 HIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTM 1116
Score = 209 bits (531), Expect = 4e-53
Identities = 150/453 (33%), Positives = 226/453 (49%), Gaps = 18/453 (3%)
Query: 252 ELAQVLL--AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
E+ Q+L+ H N ED D T + + D ++ LL + A VN + G T L
Sbjct: 495 EVLQLLVKAGAHVNSED-----DRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLL 549
Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
A G +D+V +L++ GA++E + +GHTPL AA GH +V L+ GA IN H++
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN-HTD 608
Query: 370 EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
+ +AL A + GH ++V LL AG + + TAL A GH ++ LL GA
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
Query: 430 QVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEA-----AREGHE 484
+VN + + L AA GH E+ L++ GA + + +G T L A A +GH
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 485 EMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLME 541
+V+LL+ +GA ++ ++ T L +A G +V D L++ GAD+ + TPL+
Sbjct: 729 SVVSLLIDRGAEVD-HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
Query: 542 ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 601
A+ GH +V LL GA V + + G T L+ A G+ +V LL G D H + G
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAG 847
Query: 602 RTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
TPL AA GH + LI +GA N N+ LA GH V++LL + ++
Sbjct: 848 WTPLHMAAFEGHRLICEALIEQGARTNEID-NDGRIPFILASQEGHYDCVQILLENKSNI 906
Query: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
R DG L AA GH ++V L + +V
Sbjct: 907 DQRGYDGRNALRVAALEGHRDIVELLFSHGADV 939
Score = 188 bits (477), Expect = 7e-47
Identities = 123/343 (35%), Positives = 192/343 (55%), Gaps = 16/343 (4%)
Query: 1047 IDAHTESNHD-----TALTLAC-----AGGHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
+D E NH+ TAL++A + GH +VS+LI R A+++H DK G TPL++AA
Sbjct: 697 LDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAA 756
Query: 1097 TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
GHV VV++LL+ G D++ ++ TPL A S G VV+ LL GA + +
Sbjct: 757 YEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR 815
Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
T LS+A++ G V +++ LL+ G + N R + G +PL +AA GH + L++ G+
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDA--GWTPLHMAAFEGHRLICEALIEQGART 873
Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
N +I+ + LA +G + V +LL+ K+N++ R G L AA G+ ++ +L
Sbjct: 874 N-EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Query: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
GADVN R T L I A + E + GA+++ + +G T L ++ G
Sbjct: 933 FSHGADVNCKDA-DGRPT-LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQG 990
Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
H ++VQ+L+ ADV+AADN K + L SA +GHVKVVQ L++
Sbjct: 991 HMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIE 1033
Score = 174 bits (441), Expect = 1e-42
Identities = 122/334 (36%), Positives = 181/334 (54%), Gaps = 11/334 (3%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+SN T L A G ++V++L++R A +E D G TPL LAA GH VV L+ G
Sbjct: 542 DSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+I +++ T L A GG EVV LL G + + T L AA GG+ +I+
Sbjct: 602 ANIN-HTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIV 660
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
LL GAE+N G + L+ AA GH V+ LLD G+++N + + + TAL++A
Sbjct: 661 LNLLQHGAEVNKADNE--GRTALIAAAYMGHREIVEHLLDHGAEVNHE-DVDGRTALSVA 717
Query: 1232 CF-----QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
+G A VVSLL+DR A V+H K G+TPL+ AA G+ +V +LL+ GADV+
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD-- 775
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
++ T L AA GH L+ GA +D + +G T L +AS G+ +VV+ L+
Sbjct: 776 HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD 835
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
G D + D+ TPL A +GH + + L+++
Sbjct: 836 RGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQ 869
Score = 168 bits (426), Expect = 5e-41
Identities = 117/336 (34%), Positives = 178/336 (52%), Gaps = 8/336 (2%)
Query: 1048 DAHTESNHD-TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
D E H T LTLA GH ++V+ LI A I H D+ G+T L AA GH VV
Sbjct: 570 DLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSA 629
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL G ++ ++ T L A GG +++V LL GA + T L AA G
Sbjct: 630 LLYAGVKVDC-ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMG 688
Query: 1167 YVNIIKILLNAGAEINSRT---GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
+ I++ LL+ GAE+N + L ++ L + A GH V LL+D G++++ + +
Sbjct: 689 HREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD-HCDKD 747
Query: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
T L +A ++G +VV LLL+ A+V+H G TPL+ AAS G+A V LL GA V
Sbjct: 748 GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV 807
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
++ + S T L+IA+ +G+ + L+ RG + R+ G TPL +A+ GH + +
Sbjct: 808 DS--IDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEA 865
Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L++ GA + DN P + A ++GH VQ L++
Sbjct: 866 LIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLE 901
Score = 163 bits (413), Expect = 2e-39
Identities = 112/314 (35%), Positives = 158/314 (50%), Gaps = 9/314 (2%)
Query: 1068 EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLS 1127
+E++ +L+ A + D + T I+ + LLD G + Q + T L+
Sbjct: 494 QEVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVN-QCDSNGRTLLA 550
Query: 1128 LACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGS 1187
A G +VV+LL++RGA+ E + +TPL+LAA G+ ++ L+ GA IN
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247
G + L AA GH V LL G ++ + + TAL A + G ++V LL
Sbjct: 611 --GWTALRSAAWGGHTEVVSALLYAGVKVDCA-DADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 1248 ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---TALTIAADKGH 1304
A V G T L+ AA G+ E+ LLD GA+VN V AL + A KGH
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMS 1364
LLI RGA +D +K G TPL +A+ GH DVV LL++ GADVD DN TPL++
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
Query: 1365 AFRKGHVKVVQYLV 1378
A GH VV L+
Sbjct: 788 AASMGHASVVNTLL 801
Score = 80.9 bits (198), Expect = 1e-14
Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 8/181 (4%)
Query: 1206 VKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA 1265
++LL+ G+ +N+ E +R + + + R + + LLD A+V G T L AA
Sbjct: 497 LQLLVKAGAHVNS--EDDRTSCIVRQALE-REDSIRTLLDNGASVNQCDSNGRTLLANAA 553
Query: 1266 SGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKG 1325
G +V +L+ +GAD+ T LT+AA +GH K LI GA+I+ ++ G
Sbjct: 554 YSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVN 1382
T L A+ GGH +VV L+ AG VD AD T L +A GH +V L++ EVN
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 1383 Q 1383
+
Sbjct: 672 K 672
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 237 bits (605), Expect = 1e-61
Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)
Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
V L+ A L R K S H A Q D V V+ LL V++ T
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 342
Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
+ + L +A G+Y + ++LL AN R G TPL A + +++LL+ + A
Sbjct: 343 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 401
Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
+ + + +G T + A G ++IV +LL GA+ + N G T L AA AG VEV R
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
LL +GA ++ + E +++ L +A G ++V+ LL+ A + T +T L + +G
Sbjct: 462 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
V+VA +LL++GA ++ +PL +AA G +++A LL++R A + G TPL
Sbjct: 521 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
AA ++++ LLL +GA+ +A T + T L +A ++A L+ GA+ +
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639
Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
TPL ASQEGH ++V LL GAN+H +T +G T+L A + +VAD+L + GAD
Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
+ ++ G TPL+ A G++ V FL+ +GANVN A N +T + A GH ++ +
Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 758
Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
LL HGA P +G+T L A + G+ +VV L V + TT + +
Sbjct: 759 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 812
Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
VP T L D + +E + G G + L+ D LPS
Sbjct: 813 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 856
Score = 214 bits (546), Expect = 7e-55
Identities = 167/512 (32%), Positives = 252/512 (49%), Gaps = 25/512 (4%)
Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
+T M ++ NA S A G+++ V + L G +N + G + L LA G
Sbjct: 1 MTTMLQKSDSNA------SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEG 54
Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
+ L Q LL ++V+ KG+ T L AS G ++VK+L+ A++N+QS G T L
Sbjct: 55 HVGLVQELLGRGSSVDSATKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
A +D+VK LL GAN E+G TPL A GH + +LL+ N
Sbjct: 114 YMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKG 168
Query: 370 EFKESALTLACYKGHLDMVRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVA 421
+ + AL +A K LL + AD + K T+ T L A G+V VA
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
LLL+ GA V+ A + +PL +A+ G+ + LL++RG ++ +G TPL AAR
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARS 288
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTP 538
GH+++V LLL +GA + A+T+ + L +A G E L++ A D+ L T
Sbjct: 289 GHDQVVELLLERGAPLLARTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTA 347
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L A+ GH + K LL AN +A G T L AC+ V ++L++ GA ++ +
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
E G TP+ AA GHL V L+ GA+ + T T + +A G + VV LL +G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNG 466
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
A R ++ T L A++ G T +V LL +
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Score = 163 bits (412), Expect = 2e-39
Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)
Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
I V + G+N S+ T + TP + + Q N A + P++ I A
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 181
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+ AL L + +++ R + GFTPL +AA G+V V +LL++G
Sbjct: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 235
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
++ + R TPL +A G +V LLL RG + + TPL AA G+ ++
Sbjct: 236 AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
++LL GA + +RT K G+SPL +AA HV VK LL + ++ + + TAL +A
Sbjct: 295 ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 351
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
G V LLLD++AN RA G TPL A +V +L+ GA + A + S
Sbjct: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 409
Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
T + +AA GH LL+ GA DV N +G T L +A+ G +VV+ L++ GA V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
DA + TPL A R G ++VQ L++ +
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Score = 161 bits (407), Expect = 9e-39
Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
I A TES T + +A GH +V +L+ A + + +G T L +AA AG V VV
Sbjct: 403 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL G ++A++ R + TPL +A G+ E+V LLL A+ + + YTPL ++A G
Sbjct: 462 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 520
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
V++ +LL AGA + T K G +PL +AA G + KLLL + ++ + N T
Sbjct: 521 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 577
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 636
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +A+ +GH LL+ +GA+I + K G T L LA+ +V +L +
Sbjct: 637 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
GAD DA TPL+ A G+VK+V +L+K+
Sbjct: 696 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
Score = 152 bits (384), Expect = 4e-36
Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+S+ + + A G+ + V + I ++ G L LAA GHVG+V+ LL +G
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+++ +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +++++
Sbjct: 67 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 126 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 178
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
+ + +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
+ + T L +A+ +G+ +LL+ RG ID + + G TPL A+ GH VV+L
Sbjct: 239 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 296
Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 297 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 348
Score = 145 bits (365), Expect = 6e-34
Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
+DA T L +A G E+V +L+ A + G+TPL ++A G V V +
Sbjct: 469 VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
LL+ G A S TK TPL +A G +V LLL R A + + TPL +AA
Sbjct: 528 LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 584
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
+ +LL GA ++ +K G +PL +AA + LL+ G++ N +
Sbjct: 585 YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 641
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
T L LA +G ++V+LLLD+ AN+ K+GLT L AA V +L GAD +
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
A T L +A G+ K L+ +GA+++ + K G TPL A+ GH ++ +L
Sbjct: 702 AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
+Q GA +A T L A R G++ VV L K V + E TIT+K L
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 813
Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
E + + ++ + L+ DL++ ++S
Sbjct: 814 VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 853
Score = 120 bits (300), Expect = 2e-26
Identities = 94/306 (30%), Positives = 146/306 (47%), Gaps = 42/306 (13%)
Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
AA G+++ ++ G ++ N G L AA+EGH +V LL +G+++++ T++
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 505 QETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANV 561
TAL +A G +EV L+K GA+I TPL A+QE H+++VKYLL +GAN
Sbjct: 77 N-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135
Query: 562 HATTATGDTALTYACENGHTDVADVLLQA------------------------------- 590
T G T L A + GH +LL+
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195
Query: 591 GADLEHE------SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
AD++ + +E G TPL AA G++ L+++GA V+ TA N T + +A
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVD-FTARNGITPLHVASK 254
Query: 645 GGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQ 704
G+ +V+LLL G + +DG T L AA+ GH VV LL+ +L+ +S
Sbjct: 255 RGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314
Query: 705 LPPPSQ 710
L +Q
Sbjct: 315 LHMAAQ 320
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 237 bits (605), Expect = 1e-61
Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)
Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
V L+ A L R K S H A Q D V V+ LL V++ T
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363
Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
+ + L +A G+Y + ++LL AN R G TPL A + +++LL+ + A
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422
Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
+ + + +G T + A G ++IV +LL GA+ + N G T L AA AG VEV R
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
LL +GA ++ + E +++ L +A G ++V+ LL+ A + T +T L + +G
Sbjct: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
V+VA +LL++GA ++ +PL +AA G +++A LL++R A + G TPL
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
AA ++++ LLL +GA+ +A T + T L +A ++A L+ GA+ +
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
TPL ASQEGH ++V LL GAN+H +T +G T+L A + +VAD+L + GAD
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
+ ++ G TPL+ A G++ V FL+ +GANVN A N +T + A GH ++ +
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779
Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
LL HGA P +G+T L A + G+ +VV L V + TT + +
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833
Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
VP T L D + +E + G G + L+ D LPS
Sbjct: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877
Score = 214 bits (544), Expect = 1e-54
Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
KG+ T L AS G ++VK+L+ A++N+QS G T L A +D+VK LL
Sbjct: 94 TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
GAN E+G TPL A GH + +LL+ N + + AL +A K
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
+T+ + L +A G E L++ A D+ L T L A+ GH + K LL
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
AN +A G T L AC+ V ++L++ GA ++ +E G TP+ AA GHL
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
V L+ GA+ + T T + +A G + VV LL +GA R ++ T L A+
Sbjct: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 677 KGGHTNVVSYLLDY 690
+ G T +V LL +
Sbjct: 506 RLGKTEIVQLLLQH 519
Score = 202 bits (515), Expect = 3e-51
Identities = 171/531 (32%), Positives = 254/531 (47%), Gaps = 46/531 (8%)
Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 319 DIVKVLLNEGAN------------------------IEDHN-------------ENGHTP 341
V +LL DHN E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
G +V LL+ GA ++ + +TPL A+R G VQ L+ A+ + AT N +T
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YT 532
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
+ ++ G + V +LL GA + K G T L AAK G +V LL
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Score = 163 bits (412), Expect = 2e-39
Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)
Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
I V + G+N S+ T + TP + + Q N A + P++ I A
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+ AL L + +++ R + GFTPL +AA G+V V +LL++G
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
++ + R TPL +A G +V LLL RG + + TPL AA G+ ++
Sbjct: 257 AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
++LL GA + +RT K G+SPL +AA HV VK LL + ++ + + TAL +A
Sbjct: 316 ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
G V LLLD++AN RA G TPL A +V +L+ GA + A + S
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430
Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
T + +AA GH LL+ GA DV N +G T L +A+ G +VV+ L++ GA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
DA + TPL A R G ++VQ L++ +
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 161 bits (407), Expect = 9e-39
Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)
Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
L+E GAN ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
AL L A G VA L+ GA ++ T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
PL AS+ G+ +VK LL G + A T G T L A +GH V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
++ G +PL AA+ H+ V+ L+ A V+ T + T + +A GH V +LLL
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
A+P R +G T L A K V+ L+ Y ++ ++ + ++ +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Score = 161 bits (407), Expect = 9e-39
Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
I A TES T + +A GH +V +L+ A + + +G T L +AA AG V VV
Sbjct: 424 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL G ++A++ R + TPL +A G+ E+V LLL A+ + + YTPL ++A G
Sbjct: 483 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
V++ +LL AGA + T K G +PL +AA G + KLLL + ++ + N T
Sbjct: 542 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +A+ +GH LL+ +GA+I + K G T L LA+ +V +L +
Sbjct: 658 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
GAD DA TPL+ A G+VK+V +L+K+
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Score = 159 bits (401), Expect = 4e-38
Identities = 141/462 (30%), Positives = 205/462 (44%), Gaps = 78/462 (16%)
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV--------- 351
+ + N + A G +D V L G +I N+NG L AA GHV
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 352 ------------------------EVARVLLDHGAGINTHS-NEFKESALTLACYKGHLD 386
EV +VL+ GA IN S N F + L +A + H+D
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--TPLYMAAQENHID 144
Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPA--------- 435
+V++LLE GA+Q T++ T L A GH + +LL D+ +V +PA
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 204
Query: 436 --------------------------DSFESPLTLAACGGHVELAALLIERGANLEEVND 469
+S +PL +AA G+V +A LL+ RGA ++
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264
Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
G TPL A++ G+ MV LLL +G I+A+T + T L A G +V + L++ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERGA 323
Query: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
+ +PL A+Q H+E VK+LL A V T TAL A GH V +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGG 646
LL A+ + G TPL A + + ++ L+ GA++ +A + T + +A G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMG 442
Query: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
HL +V LLL +GA P G T L AA+ G VV LL
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Score = 152 bits (384), Expect = 4e-36
Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+S+ + + A G+ + V + I ++ G L LAA GHVG+V+ LL +G
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+++ +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +++++
Sbjct: 88 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 147 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
+ + +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
+ + T L +A+ +G+ +LL+ RG ID + + G TPL A+ GH VV+L
Sbjct: 260 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
Score = 145 bits (365), Expect = 6e-34
Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
+DA T L +A G E+V +L+ A + G+TPL ++A G V V +
Sbjct: 490 VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
LL+ G A S TK TPL +A G +V LLL R A + + TPL +AA
Sbjct: 549 LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
+ +LL GA ++ +K G +PL +AA + LL+ G++ N +
Sbjct: 606 YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
T L LA +G ++V+LLLD+ AN+ K+GLT L AA V +L GAD +
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
A T L +A G+ K L+ +GA+++ + K G TPL A+ GH ++ +L
Sbjct: 723 AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
+Q GA +A T L A R G++ VV L K V + E TIT+K L
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834
Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
E + + ++ + L+ DL++ ++S
Sbjct: 835 VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874
Score = 119 bits (299), Expect = 3e-26
Identities = 99/343 (28%), Positives = 155/343 (45%), Gaps = 47/343 (13%)
Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
K + + + + A G+++ L G +N + + L LAA GHV L L+ R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
G++++ +G T L A+ G E+V +L+ +GANINAQ+ + T L +A +V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDV 145
Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN----------------- 560
+L++ GA+ TPL A Q+GH + V LL +
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 561 --------------------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
V+ TT +G T L A G+ +VA +LL GA ++ +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
G TPL A++ G+ V+ L+ +G ++ A + T + A GH VVELLL GA
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
R K+G + L AA+G H V +LL + P DV+
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQH-----KAPVDDVT 362
Score = 44.3 bits (103), Expect = 0.002
Identities = 31/94 (32%), Positives = 45/94 (47%)
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
P S + + AA G+ + G I+ N+ G L LA+ GH +VQ L+
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
G+ VD+A + T L A G +VV+ LVKE
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 237 bits (605), Expect = 1e-61
Identities = 187/595 (31%), Positives = 294/595 (49%), Gaps = 37/595 (6%)
Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
V L+ A L R K S H A Q D V V+ LL V++ T
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLLQHKAPVDDVTL 363
Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
+ + L +A G+Y + ++LL AN R G TPL A + +++LL+ + A
Sbjct: 364 DYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGA 422
Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
+ + + +G T + A G ++IV +LL GA+ + N G T L AA AG VEV R
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
LL +GA ++ + E +++ L +A G ++V+ LL+ A + T +T L + +G
Sbjct: 483 LLRNGALVDARARE-EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
V+VA +LL++GA ++ +PL +AA G +++A LL++R A + G TPL
Sbjct: 542 QVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
AA ++++ LLL +GA+ +A T + T L +A ++A L+ GA+ +
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHA-TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Query: 537 ---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
TPL ASQEGH ++V LL GAN+H +T +G T+L A + +VAD+L + GAD
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
+ ++ G TPL+ A G++ V FL+ +GANVN A N +T + A GH ++ +
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN-AKTKNGYTPLHQAAQQGHTHIINV 779
Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
LL HGA P +G+T L A + G+ +VV L V + TT + +
Sbjct: 780 LLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTIT------EKHKL 833
Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPS 768
VP T L D + +E + G G + L+ D LPS
Sbjct: 834 NVPETMTEVL---------DVSDEEGDDTMTG--DGGEYLRPEDLKELGDDSLPS 877
Score = 214 bits (544), Expect = 1e-54
Identities = 163/494 (32%), Positives = 245/494 (49%), Gaps = 19/494 (3%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
S A G+++ V + L G +N + G + L LA G+ L Q LL ++V+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
KG+ T L AS G ++VK+L+ A++N+QS G T L A +D+VK LL
Sbjct: 94 TKKGN-TALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
GAN E+G TPL A GH + +LL+ N + + AL +A K
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKS 207
Query: 388 VRFLL--EAGADQEHK------TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
LL + AD + K T+ T L A G+V VA LLL+ GA V+ A +
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
+PL +A+ G+ + LL++RG ++ +G TPL AAR GH+++V LLL +GA + A
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLA 556
+T+ + L +A G E L++ A D+ L T L A+ GH + K LL
Sbjct: 328 RTKNGL-SPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLD 386
Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
AN +A G T L AC+ V ++L++ GA ++ +E G TP+ AA GHL
Sbjct: 387 KRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNI 446
Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
V L+ GA+ + T T + +A G + VV LL +GA R ++ T L A+
Sbjct: 447 VLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIAS 505
Query: 677 KGGHTNVVSYLLDY 690
+ G T +V LL +
Sbjct: 506 RLGKTEIVQLLLQH 519
Score = 202 bits (515), Expect = 3e-51
Identities = 171/531 (32%), Positives = 254/531 (47%), Gaps = 46/531 (8%)
Query: 199 HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
+ Q +L A +G V V++LL G SV+ T++G + L +A AG E+ +VL+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 259 AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFV 318
AN+ + G TPL A+ ++D+VK LL + A+ ++ + G T L A G
Sbjct: 118 KEGANINAQSQNG-FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 319 DIVKVLLNEGAN------------------------IEDHN-------------ENGHTP 341
V +LL DHN E+G TP
Sbjct: 177 QAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTP 236
Query: 342 LMEAASAGHVEVARVLLDHGAGIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEH 400
L AA G+V VA +LL+ GA ++ T N + L +A +G+ +MV+ LL+ G +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGI--TPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
KT + T L A GH +V LLL+ GA + + SPL +AA G HVE L++
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
A +++V + T L AA GH + LLL + AN NA+ T L +AC +V
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA-LNGFTPLHIACKKNRIKV 413
Query: 521 ADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACE 577
+ L+K GA I+ TP+ A+ GHL +V LL +GA+ T G+TAL A
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 578 NGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
G +V LL+ GA ++ + +TPL A+R G VQ L+ A+ + AT N +T
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNG-YT 532
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
+ ++ G + V +LL GA + K G T L AAK G +V LL
Sbjct: 533 PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLL 583
Score = 163 bits (412), Expect = 2e-39
Identities = 127/390 (32%), Positives = 192/390 (49%), Gaps = 20/390 (5%)
Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCS-QTTSNVASQSM-------PPVYPSVDIDAHT 1051
I V + G+N S+ T + TP + + Q N A + P++ I A
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARK 202
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+ AL L + +++ R + GFTPL +AA G+V V +LL++G
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTE------SGFTPLHIAAHYGNVNVATLLLNRG 256
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
++ + R TPL +A G +V LLL RG + + TPL AA G+ ++
Sbjct: 257 AAVDFTA-RNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
++LL GA + +RT K G+SPL +AA HV VK LL + ++ + + TAL +A
Sbjct: 316 ELLLERGAPLLART--KNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTALHVA 372
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
G V LLLD++AN RA G TPL A +V +L+ GA + A + S
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITES 430
Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV 1351
T + +AA GH LL+ GA DV N +G T L +A+ G +VV+ L++ GA V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 1352 DAADNRKITPLMSAFRKGHVKVVQYLVKEV 1381
DA + TPL A R G ++VQ L++ +
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 161 bits (407), Expect = 9e-39
Identities = 121/408 (29%), Positives = 197/408 (48%), Gaps = 41/408 (10%)
Query: 337 NGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGA 396
+ + + AA AG+++ L G INT N+ +AL LA +GH+ +V+ LL G+
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
+ T + +TAL A + G EV ++L+ GA +N + + +PL +AA H+++
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQET 507
L+E GAN ++G+TPL A ++GH + VA+LL +I A+ ++T+
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Query: 508 ALTL---------------------------ACCGGFSEVADFLIKAGADIELGCS---T 537
AL L A G VA L+ GA ++ T
Sbjct: 209 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 268
Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
PL AS+ G+ +VK LL G + A T G T L A +GH V ++LL+ GA L
Sbjct: 269 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 328
Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
++ G +PL AA+ H+ V+ L+ A V+ T + T + +A GH V +LLL
Sbjct: 329 TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDY-LTALHVAAHCGHYRVTKLLLDK 387
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
A+P R +G T L A K V+ L+ Y ++ ++ + ++ +
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPI 435
Score = 161 bits (407), Expect = 9e-39
Identities = 118/334 (35%), Positives = 177/334 (52%), Gaps = 7/334 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
I A TES T + +A GH +V +L+ A + + +G T L +AA AG V VV
Sbjct: 424 IQAITESGL-TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL G ++A++ R + TPL +A G+ E+V LLL A+ + + YTPL ++A G
Sbjct: 483 LLRNGALVDARA-REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREG 541
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
V++ +LL AGA + T K G +PL +AA G + KLLL + ++ + N T
Sbjct: 542 QVDVASVLLEAGAAHSLAT--KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLT 598
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A +V LLL++ A+ AK G TPL AA ++ LL+ GA+ N
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI- 657
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +A+ +GH LL+ +GA+I + K G T L LA+ +V +L +
Sbjct: 658 -VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
GAD DA TPL+ A G+VK+V +L+K+
Sbjct: 717 HGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Score = 159 bits (401), Expect = 4e-38
Identities = 141/462 (30%), Positives = 205/462 (44%), Gaps = 78/462 (16%)
Query: 301 QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV--------- 351
+ + N + A G +D V L G +I N+NG L AA GHV
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 352 ------------------------EVARVLLDHGAGINTHS-NEFKESALTLACYKGHLD 386
EV +VL+ GA IN S N F + L +A + H+D
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF--TPLYMAAQENHID 144
Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL--DSGAQVNMPA--------- 435
+V++LLE GA+Q T++ T L A GH + +LL D+ +V +PA
Sbjct: 145 VVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDD 204
Query: 436 --------------------------DSFESPLTLAACGGHVELAALLIERGANLEEVND 469
+S +PL +AA G+V +A LL+ RGA ++
Sbjct: 205 TKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTAR 264
Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
G TPL A++ G+ MV LLL +G I+A+T + T L A G +V + L++ GA
Sbjct: 265 NGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGL-TPLHCAARSGHDQVVELLLERGA 323
Query: 530 DIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
+ +PL A+Q H+E VK+LL A V T TAL A GH V +
Sbjct: 324 PLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383
Query: 587 LLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGG 646
LL A+ + G TPL A + + ++ L+ GA++ +A + T + +A G
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-QAITESGLTPIHVAAFMG 442
Query: 647 HLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
HL +V LLL +GA P G T L AA+ G VV LL
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLL 484
Score = 152 bits (384), Expect = 4e-36
Identities = 108/354 (30%), Positives = 189/354 (53%), Gaps = 20/354 (5%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
+S+ + + A G+ + V + I ++ G L LAA GHVG+V+ LL +G
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 87
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+++ +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +++++
Sbjct: 88 SSVDSATKKG-NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
K LL GA N T ++ G +PL +A GH AV +LL+ +D ++ R AL +A
Sbjct: 147 KYLLENGA--NQSTATEDGFTPLAVALQQGHNQAVAILLE--NDTKGKV---RLPALHIA 199
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAK--------TGLTPLMEAASGGYAEVGRVLLDKGADV 1283
+ + +LLL N + ++K +G TPL AA G V +LL++GA V
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
+ + T L +A+ +G+ +LL+ RG ID + + G TPL A+ GH VV+L
Sbjct: 260 DF--TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVEL 317
Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATI 1397
L++ GA + A ++PL A + HV+ V++L++ ++ P D + Y+ +
Sbjct: 318 LLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQ--HKAPVDDVTLDYLTAL 369
Score = 145 bits (365), Expect = 6e-34
Identities = 122/400 (30%), Positives = 187/400 (46%), Gaps = 17/400 (4%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
+DA T L +A G E+V +L+ A + G+TPL ++A G V V +
Sbjct: 490 VDARAREEQ-TPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 1107 LLDKGGDIEAQSERTKD--TPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
LL+ G A S TK TPL +A G +V LLL R A + + TPL +AA
Sbjct: 549 LLEAGA---AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAH 605
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
+ +LL GA ++ +K G +PL +AA + LL+ G++ N +
Sbjct: 606 YDNQKVALLLLEKGASPHAT--AKNGYTPLHIAAKKNQMQIASTLLNYGAETNI-VTKQG 662
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
T L LA +G ++V+LLLD+ AN+ K+GLT L AA V +L GAD +
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
A T L +A G+ K L+ +GA+++ + K G TPL A+ GH ++ +L
Sbjct: 723 AHTKLGY--TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404
+Q GA +A T L A R G++ VV L K V + E TIT+K L
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYISVVDTL-KVVTE-----EVTTTTTTITEKHKLN 834
Query: 1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
E + + ++ + L+ DL++ ++S
Sbjct: 835 VPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDS 874
Score = 119 bits (299), Expect = 3e-26
Identities = 99/343 (28%), Positives = 155/343 (45%), Gaps = 47/343 (13%)
Query: 401 KTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIER 460
K + + + + A G+++ L G +N + + L LAA GHV L L+ R
Sbjct: 27 KKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 461 GANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
G++++ +G T L A+ G E+V +L+ +GANINAQ+ + T L +A +V
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDV 145
Query: 521 ADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGAN----------------- 560
+L++ GA+ TPL A Q+GH + V LL +
Sbjct: 146 VKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDT 205
Query: 561 --------------------VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG 600
V+ TT +G T L A G+ +VA +LL GA ++ +
Sbjct: 206 KSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARN 265
Query: 601 GRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGAD 660
G TPL A++ G+ V+ L+ +G ++ A + T + A GH VVELLL GA
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQID-AKTRDGLTPLHCAARSGHDQVVELLLERGAP 324
Query: 661 PTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
R K+G + L AA+G H V +LL + P DV+
Sbjct: 325 LLARTKNGLSPLHMAAQGDHVECVKHLLQH-----KAPVDDVT 362
Score = 44.3 bits (103), Expect = 0.002
Identities = 31/94 (32%), Positives = 45/94 (47%)
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
P S + + AA G+ + G I+ N+ G L LA+ GH +VQ L+
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 85
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
G+ VD+A + T L A G +VV+ LVKE
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEVVKVLVKE 119
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 226 bits (576), Expect = 2e-58
Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 341
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 457
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 458 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGF-TPLHVA 576
Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 577 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 636
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 630 --------------------------------ATANNDHTVVSLACAGGHLAVVELLLAH 657
AT +T + +A G++ +V+ LL H
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
AD + K G + L +AA+ GHT++V+ LL PN V S TT ++
Sbjct: 757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 805
Score = 222 bits (565), Expect = 4e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 144
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 145 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 381
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 382 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 559
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
A K G T L AAK G V LL+ +PN
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
Score = 213 bits (542), Expect = 2e-54
Identities = 177/559 (31%), Positives = 261/559 (46%), Gaps = 35/559 (6%)
Query: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
DE L A N + Q L A + + V+ LL+ G + N TE+G + L
Sbjct: 124 DEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 244 LACSAGYYELAQVLL-----------AMHANVE-----------------DRGNKGDITP 275
+A G+ + L+ A+H D +K TP
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP 242
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
L A+ L++ +LLL A VN G T L A G V +V++LL+ GA IE
Sbjct: 243 LHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT 302
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
++ TPL AA GHV ++ +LLDHGA I + S + +A HLD VR LL+
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYD 361
Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
A+ + T + T L A GH VA++LLD GA+ N A + +PL +A HV +
Sbjct: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
LL++ GA+++ V + G TPL A+ GH +V LL +GA+ N + ET L +A
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV-ETPLHMAARA 480
Query: 516 GFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
G +EVA +L++ A + TPL A++ GH +VK LL + AN + T G T L
Sbjct: 481 GHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
A GH + LL+ A ++ G TPL AA+ G + + L+ + A+ N A
Sbjct: 541 HIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAG 599
Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
N T + +A +L +V+LLL G P +G T L AAK V LL Y
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 659
Query: 693 NVLSVPTTDVSQLPPPSQD 711
+ + V+ L +Q+
Sbjct: 660 SANAESVQGVTPLHLAAQE 678
Score = 210 bits (535), Expect = 1e-53
Identities = 162/526 (30%), Positives = 251/526 (47%), Gaps = 44/526 (8%)
Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 357 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415
Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 474
Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 475 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 534
Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594
Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
NA + T L +A EVA L
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654
Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 655 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714
Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN A ++ +
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 773
Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
A GH +V LLL +GA P DG+T L A + G+ +V L
Sbjct: 774 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 198 bits (504), Expect = 5e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 75 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 134
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 135 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 193
Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
L+ G + + +H T L A ++
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 313
Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 314 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 372
Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 432
Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 433 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 491
Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Score = 166 bits (420), Expect = 3e-40
Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T +TAL +A G +E+V L+ A + + +KGFTPL +AA H+ VV+ LL+
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
G + Q+ T+D TPL++A G + VV
Sbjct: 167 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 223
Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 224 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 281
Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
G+V V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 282 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 395
Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ R G TPL +A H V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
Query: 1377 LVK 1379
L++
Sbjct: 456 LLQ 458
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 225
Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 226 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 285
Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 286 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 346 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Score = 160 bits (404), Expect = 2e-38
Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H E+V L+ A + GFTPL +A GH VV L++ G
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 205
Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
I A+++ T+ TPL +A V LLL RGA+
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 265
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
+ TPL +A+ G V ++++LL+ GA+I ++T +L +PL AA NGHV ++
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 323
Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
LLD G+ I A+ + N + + +A + V LLL A ++ LTPL AA G
Sbjct: 324 LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382
Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
+ V +VLLDKGA N+ + T L IA K H + ELL+ GA ID + G TP
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 440
Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L +AS GH +V+ L+Q GA + ++ + TPL A R GH +V +YL++
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 491
Score = 157 bits (396), Expect = 2e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 430 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 489 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 548 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 604
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 665 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
G VDA TPL A G++K+V++L++
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Score = 155 bits (393), Expect = 4e-37
Identities = 141/495 (28%), Positives = 231/495 (46%), Gaps = 45/495 (9%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 531 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 590 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 646
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 704
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD-------------IECMRYIATITD 1399
+PL A ++GH +V L+K N+ SD I + +TD
Sbjct: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTD 824
Query: 1400 KE---LLKKCHQC--VETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKRE 1454
+ L+ H+ ET+ + D E + +I+ +EL K A +R+
Sbjct: 825 ETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFK----------AERRD 874
Query: 1455 KRKEKRKKKKEEQKRKQEEDEENK--PKENSELPE-----DEDEEENDEDVEQEVPIEPP 1507
R +K+ + K ++ E+ P+ +PE E++E+ ++ +++ I P
Sbjct: 875 SRDVDEEKELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PS 933
Query: 1508 SATTTTTIGISATSA 1522
S T T+ IS ++
Sbjct: 934 SPATETSDNISPVAS 948
Score = 123 bits (308), Expect = 3e-27
Identities = 97/326 (29%), Positives = 155/326 (47%), Gaps = 35/326 (10%)
Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
D++ K D T+ + A G+++ A L +G +N + + L LA+ GHV++
Sbjct: 38 DRKKKADAA-TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVE 96
Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
L+ + LE +G T L AA G +E+V L+ GAN+NAQ+++ T L +A
Sbjct: 97 LLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQK-GFTPLYMAAQEN 155
Query: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGA-------------- 559
EV FL++ GA+ + TPL A Q+GH +V +L+ G
Sbjct: 156 HLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAAR 215
Query: 560 ---------------NVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 604
N + TG T L A + +VA +LL GA + + G TP
Sbjct: 216 NDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITP 275
Query: 605 LMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHR 664
L A+R G++ V+ L+ +GA + T ++ T + A GH+ + E+LL HGA +
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKT-KDELTPLHCAARNGHVRISEILLDHGAPIQAK 334
Query: 665 LKDGSTMLIEAAKGGHTNVVSYLLDY 690
K+G + + AA+G H + V LL Y
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLLLQY 360
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
+ GL L A+ G+ ++ LL K ++ +TAL IAA G + L++
Sbjct: 76 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 133
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
GA+++ +++KG TPL++A+ H +VV+ L++ GA+ + A TPL A ++GH VV
Sbjct: 134 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 193
Query: 1375 QYLV 1378
+L+
Sbjct: 194 AHLI 197
Score = 65.5 bits (158), Expect = 7e-10
Identities = 39/121 (32%), Positives = 65/121 (53%), Gaps = 2/121 (1%)
Query: 1259 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHI 1318
T + AA G + L G D+N + L +A+ +GH K L+H+ +
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHKEIIL 104
Query: 1319 DVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
+ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++ H++VV++L+
Sbjct: 105 ETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLL 164
Query: 1379 K 1379
+
Sbjct: 165 E 165
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 226 bits (576), Expect = 2e-58
Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
AT +T + +A G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
AD + K G + L +AA+ GHT++V+ LL PN V S TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 222 bits (565), Expect = 4e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
A K G T L AAK G V LL+ +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 211 bits (537), Expect = 7e-54
Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)
Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN A ++ +
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740
Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
A GH +V LLL +GA P DG+T L A + G+ T+ S++L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
+ +S P T V ++ S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822
Score = 198 bits (504), Expect = 5e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 166 bits (420), Expect = 3e-40
Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T +TAL +A G +E+V L+ A + + +KGFTPL +AA H+ VV+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
G + Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
G+V V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ R G TPL +A H V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1377 LVK 1379
L++
Sbjct: 423 LLQ 425
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 160 bits (404), Expect = 2e-38
Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H E+V L+ A + GFTPL +A GH VV L++ G
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
I A+++ T+ TPL +A V LLL RGA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
+ TPL +A+ G V ++++LL+ GA+I ++T +L +PL AA NGHV ++
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290
Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
LLD G+ I A+ + N + + +A + V LLL A ++ LTPL AA G
Sbjct: 291 LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
+ V +VLLDKGA N+ + T L IA K H + ELL+ GA ID + G TP
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L +AS GH +V+ L+Q GA + ++ + TPL A R GH +V +YL++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 157 bits (398), Expect = 1e-37
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
Query: 1518 SATSA 1522
S ++
Sbjct: 903 SPVAS 907
Score = 157 bits (396), Expect = 2e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 79.7 bits (195), Expect = 3e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 66.6 bits (161), Expect = 3e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1369 GHVKVVQYLVK 1379
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
+ GL L A+ G+ ++ LL K ++ +TAL IAA G + L++
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
GA+++ +++KG TPL++A+ H +VV+ L++ GA+ + A TPL A ++GH VV
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 1375 QYLV 1378
+L+
Sbjct: 161 AHLI 164
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 226 bits (576), Expect = 2e-58
Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
AT +T + +A G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
AD + K G + L +AA+ GHT++V+ LL PN V S TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 222 bits (565), Expect = 4e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
A K G T L AAK G V LL+ +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 211 bits (537), Expect = 7e-54
Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)
Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN A ++ +
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740
Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
A GH +V LLL +GA P DG+T L A + G+ T+ S++L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
+ +S P T V ++ S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822
Score = 198 bits (504), Expect = 5e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 166 bits (420), Expect = 3e-40
Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T +TAL +A G +E+V L+ A + + +KGFTPL +AA H+ VV+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
G + Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
G+V V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ R G TPL +A H V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1377 LVK 1379
L++
Sbjct: 423 LLQ 425
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 160 bits (404), Expect = 2e-38
Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H E+V L+ A + GFTPL +A GH VV L++ G
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
I A+++ T+ TPL +A V LLL RGA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
+ TPL +A+ G V ++++LL+ GA+I ++T +L +PL AA NGHV ++
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290
Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
LLD G+ I A+ + N + + +A + V LLL A ++ LTPL AA G
Sbjct: 291 LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
+ V +VLLDKGA N+ + T L IA K H + ELL+ GA ID + G TP
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L +AS GH +V+ L+Q GA + ++ + TPL A R GH +V +YL++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 157 bits (398), Expect = 1e-37
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
Query: 1518 SATSA 1522
S ++
Sbjct: 903 SPVAS 907
Score = 157 bits (396), Expect = 2e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 79.7 bits (195), Expect = 3e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 66.6 bits (161), Expect = 3e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1369 GHVKVVQYLVK 1379
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
+ GL L A+ G+ ++ LL K ++ +TAL IAA G + L++
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
GA+++ +++KG TPL++A+ H +VV+ L++ GA+ + A TPL A ++GH VV
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 1375 QYLV 1378
+L+
Sbjct: 161 AHLI 164
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 226 bits (576), Expect = 2e-58
Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
AT +T + +A G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
AD + K G + L +AA+ GHT++V+ LL PN V S TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 222 bits (565), Expect = 4e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
A K G T L AAK G V LL+ +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 211 bits (537), Expect = 7e-54
Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)
Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN A ++ +
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740
Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
A GH +V LLL +GA P DG+T L A + G+ T+ S++L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
+ +S P T V ++ S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822
Score = 198 bits (504), Expect = 5e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 166 bits (420), Expect = 3e-40
Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T +TAL +A G +E+V L+ A + + +KGFTPL +AA H+ VV+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
G + Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
G+V V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ R G TPL +A H V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1377 LVK 1379
L++
Sbjct: 423 LLQ 425
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 160 bits (404), Expect = 2e-38
Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H E+V L+ A + GFTPL +A GH VV L++ G
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
I A+++ T+ TPL +A V LLL RGA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
+ TPL +A+ G V ++++LL+ GA+I ++T +L +PL AA NGHV ++
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290
Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
LLD G+ I A+ + N + + +A + V LLL A ++ LTPL AA G
Sbjct: 291 LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
+ V +VLLDKGA N+ + T L IA K H + ELL+ GA ID + G TP
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L +AS GH +V+ L+Q GA + ++ + TPL A R GH +V +YL++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 157 bits (398), Expect = 1e-37
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
Query: 1518 SATSA 1522
S ++
Sbjct: 903 SPVAS 907
Score = 157 bits (396), Expect = 2e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 79.7 bits (195), Expect = 3e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 66.6 bits (161), Expect = 3e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1369 GHVKVVQYLVK 1379
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
+ GL L A+ G+ ++ LL K ++ +TAL IAA G + L++
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
GA+++ +++KG TPL++A+ H +VV+ L++ GA+ + A TPL A ++GH VV
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 1375 QYLV 1378
+L+
Sbjct: 161 AHLI 164
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 226 bits (576), Expect = 2e-58
Identities = 179/529 (33%), Positives = 257/529 (48%), Gaps = 47/529 (8%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G+V VR LLD G + T++ + L A G+ ++++LL A ++ + G ++P
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG-LSP 308
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
+ A+ G +LD V+LLL +DA+++ + T L A G + KVLL++GA
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACYKGHLDMVRFLL 392
NG TPL A HV V +LL GA I+ + ES LT +A + GHL +V+ LL
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVT----ESGLTPLHVASFMGHLPIVKNLL 424
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
+ GA ++ T L A GH EVA+ LL + A+VN A ++PL AA GH
Sbjct: 425 QRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+E AN G+TPL AAREGH E V LL + A+ T++ T L +A
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKK-GFTPLHVA 543
Query: 513 CCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGD 569
G VA+ L++ A TPL A +L++VK LL G + H+ G
Sbjct: 544 AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGY 603
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN- 628
T L A + +VA LLQ G ES G TPL AA+ GH V L+SK AN N
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 629 -------------------------------RATANNDHTVVSLACAGGHLAVVELLLAH 657
AT +T + +A G++ +V+ LL H
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 658 GADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPNNVLSVPTTDVS 703
AD + K G + L +AA+ GHT++V+ LL PN V S TT ++
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLA 772
Score = 222 bits (565), Expect = 4e-57
Identities = 173/517 (33%), Positives = 255/517 (49%), Gaps = 41/517 (7%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G V V +LL + + T++G + L +A AG E+ + L+ ANV + KG
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGA-- 329
TPL A+ +L++VK LL + A+ N + G T L A G ++V L+N G
Sbjct: 112 -FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 330 ---------------------------NIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
N + ++ G TPL AA ++ VA++LL+ GA
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 363 GIN-THSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA 421
+N T N + L +A +G++ MVR LL+ GA E KT + T L A +GHV ++
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 422 RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAARE 481
+LLD GA + + SP+ +AA G H++ LL++ A ++++ + TPL AA
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHC 348
Query: 482 GHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TP 538
GH + +LL +GA N++ T L +AC V + L+K GA I+ TP
Sbjct: 349 GHHRVAKVLLDKGAKPNSRA-LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L AS GHL +VK LL GA+ + + +T L A GHT+VA LLQ A + ++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ +TPL AAR GH V+ L+ AN N AT HT + +A GH+ V LL
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAG-HTPLHIAAREGHVETVLALLEKE 526
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD---YPN 692
A K G T L AAK G V LL+ +PN
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Score = 211 bits (537), Expect = 7e-54
Identities = 169/563 (30%), Positives = 267/563 (47%), Gaps = 55/563 (9%)
Query: 203 QVDTRSLAE------ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Q++T++ E A +G V LLD G + T+ G S + +A + + ++
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGG 316
LL A ++D +TPL A+ G+ + K+LL A NS++ G T L AC
Sbjct: 324 LLQYDAEIDDI-TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382
Query: 317 FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESAL 376
V ++++LL GA+I+ E+G TPL A+ GH+ + + LL GA N SN E+ L
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPL 441
Query: 377 TLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPAD 436
+A GH ++ ++LL+ A K + T L A GH + +LLL++ A N+
Sbjct: 442 HMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATT 501
Query: 437 SFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGAN 496
+ +PL +AA GHVE L+E+ A+ + +G+TPL AA+ G + LLL + A+
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561
Query: 497 INAQTEE--------------------------------TQETALTLACCGGFSEVADFL 524
NA + T L +A EVA L
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621
Query: 525 IKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHT 581
++ G TPL A+QEGH E+V LL+ AN + +G T L + GH
Sbjct: 622 LQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 582 DVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSL 641
VADVL++ G ++ + G TPL A+ G++ V+FL+ A+VN A ++ +
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQ 740
Query: 642 ACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH----------TNVVSYLLDYP 691
A GH +V LLL +GA P DG+T L A + G+ T+ S++L
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSD 800
Query: 692 NNVLSVPTTDVSQLPPPSQDQSQ 714
+ +S P T V ++ S+D+ +
Sbjct: 801 KHRMSFPET-VDEILDVSEDEGE 822
Score = 198 bits (504), Expect = 5e-50
Identities = 146/453 (32%), Positives = 226/453 (49%), Gaps = 35/453 (7%)
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
N+ + L AS G++ +V LL + + + + GNTAL A G ++V+ L+N G
Sbjct: 42 NQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYG 101
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
AN+ ++ G TPL AA H+EV + LL++GA N + E + L +A +GH ++V
Sbjct: 102 ANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV-ATEDGFTPLAVALQQGHENVV 160
Query: 389 RFLLEAGADQEHKTDEMH-----------------------------TALMEACMDGHVE 419
L+ G + + +H T L A ++
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 420 VARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA 479
VA+LLL+ GA VN + +PL +A+ G+V + LL++RGA +E + TPL AA
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAA 280
Query: 480 REGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCS 536
R GH + +LL GA I A+T+ + + +A G + L++ A DI L
Sbjct: 281 RNGHVRISEILLDHGAPIQAKTKNGL-SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL 339
Query: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
TPL A+ GH + K LL GA ++ G T L AC+ H V ++LL+ GA ++
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDA 399
Query: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
+E G TPL A+ GHL V+ L+ +GA+ N + + T + +A GH V + LL
Sbjct: 400 VTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQ 458
Query: 657 HGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ A + KD T L AA+ GHTN+V LL+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Score = 166 bits (420), Expect = 3e-40
Identities = 117/363 (32%), Positives = 186/363 (51%), Gaps = 45/363 (12%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T +TAL +A G +E+V L+ A + + +KGFTPL +AA H+ VV+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 1111 GGDIEAQSERTKD--TPLSLACSGGRQEVV-----------------------------D 1139
G + Q+ T+D TPL++A G + VV
Sbjct: 134 GAN---QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAA 190
Query: 1140 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAM 1199
+LL N + + + +TPL +AA +N+ ++LLN GA +N + GI+PL +A+
Sbjct: 191 VLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPLHIASR 248
Query: 1200 NGHVPAVKLLLDMGSDINAQIETNRNTALT---LACFQGRAEVVSLLLDRKANVEHRAKT 1256
G+V V+LLLD G AQIET LT A G + +LLD A ++ + K
Sbjct: 249 RGNVIMVRLLLDRG----AQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGA 1316
GL+P+ AA G + + R+LL A+++ + T L +AA GH++ ++L+ +GA
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEID--DITLDHLTPLHVAAHCGHHRVAKVLLDKGA 362
Query: 1317 HIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ R G TPL +A H V++LL++ GA +DA +TPL A GH+ +V+
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 1377 LVK 1379
L++
Sbjct: 423 LLQ 425
Score = 160 bits (405), Expect = 1e-38
Identities = 126/398 (31%), Positives = 197/398 (49%), Gaps = 35/398 (8%)
Query: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
T + AA +G+++ A L +G INT N+ + L LA +GH+ MV LL E
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILE 72
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
T + +TAL A + G EV R L++ GA VN + +PL +AA H+E+ L+E
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA---------NINAQTEETQETALT 510
GAN ++G+TPL A ++GHE +VA L+ G +I A+ ++T+ A+
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 511 L--------ACCGGFS-----------EVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
L GF+ VA L+ GA + TPL AS+ G++
Sbjct: 193 LQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNV 252
Query: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
+V+ LL GA + T T L A NGH ++++LL GA ++ +++ G +P+ A
Sbjct: 253 IMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
A+ HL V+ L+ A ++ T DH T + +A GH V ++LL GA P R +
Sbjct: 313 AQGDHLDCVRLLLQYDAEIDDITL--DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G T L A K H V+ LL ++ +V + ++ L
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Score = 160 bits (404), Expect = 2e-38
Identities = 120/351 (34%), Positives = 176/351 (50%), Gaps = 33/351 (9%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H E+V L+ A + GFTPL +A GH VV L++ G
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV 172
Query: 1114 ------IEAQSERTKD-------------------TPLSLACSGGRQEVVDLLLARGANK 1148
I A+++ T+ TPL +A V LLL RGA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV 232
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
+ TPL +A+ G V ++++LL+ GA+I ++T +L +PL AA NGHV ++
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDEL--TPLHCAARNGHVRISEI 290
Query: 1209 LLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGG 1268
LLD G+ I A+ + N + + +A + V LLL A ++ LTPL AA G
Sbjct: 291 LLDHGAPIQAKTK-NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 1269 YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
+ V +VLLDKGA N+ + T L IA K H + ELL+ GA ID + G TP
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGF--TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTP 407
Query: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L +AS GH +V+ L+Q GA + ++ + TPL A R GH +V +YL++
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 157 bits (398), Expect = 1e-37
Identities = 135/485 (27%), Positives = 229/485 (47%), Gaps = 33/485 (6%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+T L +A GH E+ L+ AK+ + K TPL AA GH +V++LL+ +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
+ TPL +A G E V LL + A++ +TPL +AA G V + ++LL
Sbjct: 498 LATT-AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
A N+ K G++PL +A + ++ VKLLL G ++ N T L +A Q
Sbjct: 557 ERDAHPNA--AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-WNGYTPLHIAAKQN 613
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
+ EV LL + + G+TPL AA G+AE+ +LL K A+ N S T
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGN--KSGLTP 671
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
L + A +GH ++LI G +D + G TPL +AS+ G+ +V+ L+Q ADV+A
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 1356 NRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSD----IECMRYIATITDKELLKKCHQ 1408
+PL A ++GH +V L+K N+ SD + + + I+ ++LK
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK---- 787
Query: 1409 CVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ- 1467
+V + ++K+ + +D E + L + + +R++ R +E++
Sbjct: 788 ----VVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEELISFKAERRDSRDVDEEKEL 843
Query: 1468 -----KRKQEEDEENKPKENSELPE-----DEDEEENDEDVEQEVPIEPPSATTTTTIGI 1517
K Q + P+ +PE E++E+ ++ +++ I P S T T+ I
Sbjct: 844 LDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLI-PSSPATETSDNI 902
Query: 1518 SATSA 1522
S ++
Sbjct: 903 SPVAS 907
Score = 157 bits (396), Expect = 2e-37
Identities = 119/333 (35%), Positives = 166/333 (49%), Gaps = 7/333 (2%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
IDA TES T L +A GH +V L+ R A + K TPL +AA AGH V +
Sbjct: 397 IDAVTESGL-TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
LL + A++ + TPL A G +V LLL AN + +TPL +AA G
Sbjct: 456 LLQNKAKVNAKA-KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+V + LL E + +K G +PL +AA G V +LLL+ + NA + N T
Sbjct: 515 HVETVLALLEK--EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLT 571
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A ++V LLL R + A G TPL AA EV R LL G NA
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 1287 PVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
V T L +AA +GH + LL+ + A+ ++ NK G TPL L + GH V +L++
Sbjct: 632 SVQGV--TPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689
Query: 1347 AGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
G VDA TPL A G++K+V++L++
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Score = 79.7 bits (195), Expect = 3e-14
Identities = 53/159 (33%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
E +T + A++ G+L+ L +G +++ G L A + GH + LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVV 651
LE ++ G T L AA AG V+ L++ GANVN A + T + +A HL VV
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVV 127
Query: 652 ELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
+ LL +GA+ +DG T L A + GH NVV++L++Y
Sbjct: 128 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 66.6 bits (161), Expect = 3e-10
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 2/131 (1%)
Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1308
+V R T + AA G + L G D+N + L +A+ +GH K
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMV 61
Query: 1309 ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRK 1368
L+H+ ++ KKGNT L +A+ G +VV+ LV GA+V+A + TPL A ++
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 1369 GHVKVVQYLVK 1379
H++VV++L++
Sbjct: 122 NHLEVVKFLLE 132
Score = 66.6 bits (161), Expect = 3e-10
Identities = 40/124 (32%), Positives = 70/124 (56%), Gaps = 2/124 (1%)
Query: 1255 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHR 1314
+ GL L A+ G+ ++ LL K ++ +TAL IAA G + L++
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHK--EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
Query: 1315 GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVV 1374
GA+++ +++KG TPL++A+ H +VV+ L++ GA+ + A TPL A ++GH VV
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 1375 QYLV 1378
+L+
Sbjct: 161 AHLI 164
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 225 bits (573), Expect = 5e-58
Identities = 161/523 (30%), Positives = 261/523 (49%), Gaps = 46/523 (8%)
Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
D L A G+ N V+ LLD G ++ T +G + L +G+ ++ ++LL A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
+ G ++PL A+ G +L+ V+LLL H+ V+ + TAL A G + KVL
Sbjct: 328 LSKTKNG-LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT---LACY 381
L++ AN NG TPL A ++V +LL HGA I + ES LT +A +
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT----ESGLTPIHVAAF 442
Query: 382 KGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
GH+++V L+ GA TAL A G EV R L+ GAQV A ++P
Sbjct: 443 MGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTP 502
Query: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
L ++A G ++ L+++GA+ GYTPL +AREGHE++ A LL GA+++ T
Sbjct: 503 LHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT 562
Query: 502 EETQETALTLACCGGFSEVADFLIKAGAD---------------------------IELG 534
++ T L +A G EVA+ L++ A ++ G
Sbjct: 563 KK-GFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQG 621
Query: 535 CS---------TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
S TPL A+++ +++ LL GA+ +A T G ++ A + GH D+
Sbjct: 622 ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVS 681
Query: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
+LL A++ ++ G TPL AA+ + + L+++GA+V+ A +T + + C
Sbjct: 682 LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD-AQTKMGYTPLHVGCHY 740
Query: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
G++ +V LL H A + K+G T L +AA+ GHT++++ LL
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLL 783
Score = 220 bits (561), Expect = 1e-56
Identities = 173/571 (30%), Positives = 280/571 (49%), Gaps = 32/571 (5%)
Query: 179 VSCALDEAAAALTRMKAENS--HNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTE 236
V LD AA L++ K S H A Q D +N V+ LL V++ T
Sbjct: 317 VEMLLDRAAPILSKTKNGLSPLHMATQGD-----------HLNCVQLLLQHNVPVDDVTN 365
Query: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
+ + L +A G+Y++A+VLL AN + G TPL A + +++LLL H A
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG-FTPLHIACKKNRIKVMELLLKHGA 424
Query: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
+ + + +G T + A G V+IV L++ GA+ N G T L AA +G EV R
Sbjct: 425 SIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
L+ GA + + + ++ L ++ G D+V+ LL+ GA T +T L + +G
Sbjct: 485 LVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
H +VA LLD GA +++ +PL +AA G +E+A LL+++ A+ + G TPL
Sbjct: 544 HEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLH 603
Query: 477 EAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS 536
AA ++++ LLL QGA+ +A + T L +A ++A L++ GAD
Sbjct: 604 VAAHYDNQKVALLLLDQGASPHAAAKNGY-TPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 537 TPLME---ASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD 593
+ A+QEGH+++V LL ANV+ + +G T L A + +VA+VL+ GA
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAH 722
Query: 594 LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVEL 653
++ +++ G TPL G++ V FL+ A VN A N +T + A GH ++ +
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN-AKTKNGYTPLHQAAQQGHTHIINV 781
Query: 654 LLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713
LL + A P +G+T L A + G+ +VV L ++ TT V++ + +
Sbjct: 782 LLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMT--TTTVTE-----KHKM 834
Query: 714 QVPRVPTHTLAMVVPPQEPDRTSQENSPALL 744
VP L M D + N+P +L
Sbjct: 835 NVPETMNEVLDM-----SDDEVRKANAPEML 860
Score = 197 bits (501), Expect = 1e-49
Identities = 157/498 (31%), Positives = 245/498 (49%), Gaps = 20/498 (4%)
Query: 198 SHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVL 257
+H A Q+ E ++ + RK R + ++ S L A AG+ E A
Sbjct: 2 AHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYL-RAARAGHLEKALDY 60
Query: 258 LAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
+ ++ + N+ + L AS G++++V LL +A+V++ + GNTAL A G
Sbjct: 61 IKNGVDI-NICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
++VKVL+ GAN+ ++NG TPL AA H+EV + LLD+GA + + E + L
Sbjct: 120 AEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATEDGFTPLA 178
Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
+A +GH +V LLE + + +H A + + A LLL + ++ + S
Sbjct: 179 VALQQGHDQVVSLLLENDTKGKVRLPALHIAARK----DDTKAAALLLQNDNNADVESKS 234
Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
+PL +AA G++ +A LL+ R A ++ TPL A++ G+ MV LLL +GA I
Sbjct: 235 GFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 498 NAQTEETQETALTLACCG---GFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL 550
+A+T + LT CG G +V + L+ A I + G S PL A+Q HL
Sbjct: 295 DAKTRD----GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS-PLHMATQGDHLNC 349
Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
V+ LL V T TAL A GH VA VLL A+ ++ G TPL A +
Sbjct: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409
Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
+ ++ L+ GA++ +A + T + +A GH+ +V L+ HGA P G T
Sbjct: 410 KNRIKVMELLLKHGASI-QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGET 468
Query: 671 MLIEAAKGGHTNVVSYLL 688
L AA+ G VV YL+
Sbjct: 469 ALHMAARSGQAEVVRYLV 486
Score = 171 bits (434), Expect = 6e-42
Identities = 197/816 (24%), Positives = 347/816 (42%), Gaps = 97/816 (11%)
Query: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKT 402
+ AA AGH+E A + +G IN N+ +AL LA +GH+++V LL+ A+ + T
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINI-CNQNGLNALHLASKEGHVEVVSELLQREANVDAAT 104
Query: 403 DEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA 462
+ +TAL A + G EV ++L+ +GA VN + + +PL +AA H+E+ L++ GA
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Query: 463 NLEEVNDEGYTPLMEAAREGHEEMVALLLAQ---------GANINAQTEETQETALTL-- 511
+ ++G+TPL A ++GH+++V+LLL +I A+ ++T+ AL L
Sbjct: 165 SQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQN 224
Query: 512 -----------------ACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELV 551
A G VA L+ A ++ TPL AS+ G+ +V
Sbjct: 225 DNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMV 284
Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARA 611
K LL GA + A T G T L +GH V ++LL A + +++ G +PL A +
Sbjct: 285 KLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344
Query: 612 GHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM 671
HL VQ L+ V+ T N+ T + +A GH V ++LL A+P + +G T
Sbjct: 345 DHLNCVQLLLQHNVPVDDVT-NDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTP 403
Query: 672 LIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHTLAMV----V 727
L A K V+ LL + ++ +V + ++ P H A + +
Sbjct: 404 LHIACKKNRIKVMELLLKHGASIQAVTESGLT---------------PIHVAAFMGHVNI 448
Query: 728 PPQEPDRTSQENSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPYQPLECIVEETEGKLN 787
Q + N+ T+ + ++L +A + Y + E + K +
Sbjct: 449 VSQLMHHGASPNT---------TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499
Query: 788 ELGQRISA-IEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKKKILKELQKVERQLQ 846
+ ISA + KA + L QG N + + + L L
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559
Query: 847 MKTQQQFTKEYLETK-GQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFS---ELPQVDTI 902
+ T++ FT ++ K G+ + +L Q + P+ G L H + + +V +
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQ---KSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
Query: 903 LFKDNDVDDEQQSPPSAEQIDFVPV--------QPLSSPQCNFSSDLGS---NGTNSLEL 951
L D+ SP +A + + P+ +++ + +D + G S+ L
Sbjct: 617 LL------DQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
Query: 952 QKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGS 1011
G+ +V + G + + + GL TP +D + V G+
Sbjct: 671 AAQEGHVDMVS----LLLGRNANVNLSNKSGL---TPLHLAAQ--EDRVNVAEVLVNQGA 721
Query: 1012 NSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELV 1071
+ +QT TP N+ + + S ++A T++ + T L A GH ++
Sbjct: 722 HVDAQTKMGYTPLHVGCHYGNIKIVNF-LLQHSAKVNAKTKNGY-TPLHQAAQQGHTHII 779
Query: 1072 SVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
+VL+ +A G T L +A G++ VV+ L
Sbjct: 780 NVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 166 bits (421), Expect = 2e-40
Identities = 137/467 (29%), Positives = 209/467 (44%), Gaps = 48/467 (10%)
Query: 944 NGTNSLELQKVSGNQQIVGQPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIA-- 1001
NG N+L L G+ ++V + L+Q + AT + L
Sbjct: 73 NGLNALHLASKEGHVEVVSE------------LLQREANVDAATKKGNTALHIASLAGQA 120
Query: 1002 -AVSTRVPTGSNSSSQTTECLTP----------ESCSQTTSNVASQSMPPVYPSVDIDAH 1050
V V G+N ++Q+ TP E N ASQS+ +
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180
Query: 1051 TESNHDT-----------------ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLI 1093
+ HD AL +A + ++L+ D + K GFTPL
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240
Query: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNV 1153
+AA G++ V +LL++ ++ + R TPL +A G +V LLL RGA + +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTA-RNDITPLHVASKRGNANMVKLLLDRGAKIDAKTR 299
Query: 1154 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
TPL A G+ ++++LL+ A I S+T K G+SPL +A H+ V+LLL
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRAAPILSKT--KNGLSPLHMATQGDHLNCVQLLLQHN 357
Query: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
++ + + TAL +A G +V +LLD+KAN +A G TPL A +V
Sbjct: 358 VPVD-DVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
+LL GA + A V S T + +AA GH L+H GA + N +G T L +A+
Sbjct: 417 ELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAA 474
Query: 1334 NGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
G +VV+ LVQ GA V+A TPL + R G +VQ L+++
Sbjct: 475 RSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Score = 157 bits (397), Expect = 1e-37
Identities = 126/408 (30%), Positives = 196/408 (48%), Gaps = 48/408 (11%)
Query: 1048 DAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEIL 1107
D +S+ + + A GH E I I ++ G L LA+ GHV VV L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 1108 LDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGY 1167
L + +++A +++ +T L +A G+ EVV +L+ GAN ++ + +TPL +AA +
Sbjct: 94 LQREANVDAATKK-GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
Query: 1168 VNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD---------------- 1211
+ ++K LL+ GA + T G +PL +A GH V LLL+
Sbjct: 153 LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210
Query: 1212 -----------MGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLT 1259
+ +D NA +E+ T L +A G V +LLL+R A V+ A+ +T
Sbjct: 211 RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270
Query: 1260 PLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAH 1317
PL A+ G A + ++LLD+GA ++A +RD T L A GH + E+L+ R A
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDA----KTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Query: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
I + K G +PL +A+ G H + VQLL+Q VD N +T L A GH KV + L
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Query: 1378 V--------KEVNQF-PSDIECMRYIATITDKELLKKCHQCVETIVKA 1416
+ K +N F P I C + I ELL K ++ + ++
Sbjct: 387 LDKKANPNAKALNGFTPLHIACKK--NRIKVMELLLKHGASIQAVTES 432
Score = 151 bits (382), Expect = 7e-36
Identities = 115/373 (30%), Positives = 180/373 (48%), Gaps = 37/373 (9%)
Query: 1047 IDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
I A TES T + +A GH +VS L+ A + +G T L +AA +G VV
Sbjct: 426 IQAVTESGL-TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRY 484
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGG 1166
L+ G +EA++ + TPL ++ G+ ++V LL +GA+ S YTPL L+A G
Sbjct: 485 LVQDGAQVEAKA-KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG 543
Query: 1167 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNT 1226
+ ++ LL+ GA ++ T K G +PL +AA G + LLL + +A ++ T
Sbjct: 544 HEDVAAFLLDHGASLSITT--KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGL-T 600
Query: 1227 ALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1286
L +A +V LLLD+ A+ AK G TPL AA ++ LL+ GAD NA
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Query: 1287 P----------------------------VPSSRDTALT---IAADKGHYKFCELLIHRG 1315
V S + LT +AA + E+L+++G
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 1316 AHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQ 1375
AH+D + K G TPL + + G+ +V L+Q A V+A TPL A ++GH ++
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780
Query: 1376 YLVKEVNQFPSDI 1388
L++ N P+++
Sbjct: 781 VLLQN-NASPNEL 792
Score = 145 bits (366), Expect = 5e-34
Identities = 114/369 (30%), Positives = 178/369 (48%), Gaps = 14/369 (3%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L ++ G ++V L+ + A G+TPL L+A GH V LLD G +
Sbjct: 501 TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
+++ TPL +A G+ EV +LLL + A+ + S TPL +AA + +LL+
Sbjct: 561 TTKKGF-TPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619
Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
GA + +K G +PL +AA + LL+ G+D NA + ++ LA +G
Sbjct: 620 QGA--SPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANA-VTRQGIASVHLAAQEGH 676
Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
++VSLLL R ANV K+GLTPL AA V VL+++GA V+A T L
Sbjct: 677 VDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGY--TPL 734
Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
+ G+ K L+ A ++ + K G TPL A+ GH ++ +L+Q A +
Sbjct: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTV 794
Query: 1357 RKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCHQCVETIVKA 1416
T L A R G++ VV L K V + E M T+T+K + + + ++
Sbjct: 795 NGNTALGIARRLGYISVVDTL-KIVTE-----ETMT-TTTVTEKHKM-NVPETMNEVLDM 846
Query: 1417 KDQQAAEAN 1425
D + +AN
Sbjct: 847 SDDEVRKAN 855
Score = 134 bits (337), Expect = 1e-30
Identities = 105/317 (33%), Positives = 160/317 (50%), Gaps = 10/317 (3%)
Query: 397 DQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAAL 456
D++ K+D + + + A GH+E A + +G +N+ + + L LA+ GHVE+ +
Sbjct: 34 DRKKKSDA-NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSE 92
Query: 457 LIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGG 516
L++R AN++ +G T L A+ G E+V +L+ GAN+NAQ++ T L +A
Sbjct: 93 LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF-TPLYMAAQEN 151
Query: 517 FSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALT 573
EV FL+ GA L TPL A Q+GH ++V LL + AL
Sbjct: 152 HLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLP----ALH 207
Query: 574 YACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATAN 633
A T A +LLQ + + ES+ G TPL AA G++ L+++ A V+ TA
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD-FTAR 266
Query: 634 NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNN 693
ND T + +A G+ +V+LLL GA + +DG T L A+ GH VV LLD
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Query: 694 VLSVPTTDVSQLPPPSQ 710
+LS +S L +Q
Sbjct: 327 ILSKTKNGLSPLHMATQ 343
Score = 87.4 bits (215), Expect = 2e-16
Identities = 65/203 (32%), Positives = 99/203 (48%), Gaps = 15/203 (7%)
Query: 1061 LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSER 1120
LA GH ++VS+L+ R+A + +K G TPL LAA V V E+L+++G ++AQ++
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAE 1180
TPL + C G ++V+ LL A + + YTPL AA G+ +II +LL A
Sbjct: 730 GY-TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788
Query: 1181 INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVV 1240
N T + G + L +A G++ V L + ET T +T E +
Sbjct: 789 PNELTVN--GNTALGIARRLGYISVVDTLKIVTE------ETMTTTTVTEKHKMNVPETM 840
Query: 1241 SLLLD------RKANVEHRAKTG 1257
+ +LD RKAN G
Sbjct: 841 NEVLDMSDDEVRKANAPEMLSDG 863
Score = 35.4 bits (80), Expect = 0.72
Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 16/181 (8%)
Query: 1932 SCPITVSSVVAAS-QQLCVTNTRTPSSVRKQLFACVPKTSP-PATVISSVTSTCSSLPSV 1989
+ PITV + L +++ TPS+ + V SP +T+ +S TS+ S+ V
Sbjct: 1508 TAPITVPGPAKSGFTSLSSSSSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDV 1567
Query: 1990 SSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMANLCTPSSTAN 2049
+S PI S + ++ + SQ+ + Q A P T+ P+ L S++
Sbjct: 1568 AS-PIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAV----TEATPLKGLA--SNSTF 1620
Query: 2050 SCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVSDLSPMSMPFASNSEPAPLTLTS 2109
S +S T G+ S + TP +S P S ++ S+PF S A ++S
Sbjct: 1621 SSRTSPVTTAGSLLERSSITMTPPAS-------PKSNINMYSSSLPFKSIITSAAPLISS 1673
Query: 2110 P 2110
P
Sbjct: 1674 P 1674
Score = 35.4 bits (80), Expect = 0.72
Identities = 36/140 (25%), Positives = 60/140 (42%), Gaps = 13/140 (9%)
Query: 2050 SCSSSASNTPGAPETHPS---SSPTPTSSNTQEEAQPSSVSDLSPMSMP---FASNSEPA 2103
S SSS+SNTP A S+P+P S T + SSV +S ++ P F + S P
Sbjct: 1523 SLSSSSSNTPSASPLKSIWSVSTPSPIKS-TLGASTTSSVKSISDVASPIRSFRTMSSPI 1581
Query: 2104 PLTLT-SPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIFVT 2162
++ SP + + + P + P + +F S T S+
Sbjct: 1582 KTVVSQSPYNIQVSSGTLARAPAVTEATPLKG--LASNSTFSSRTSPVTT---AGSLLER 1636
Query: 2163 NPVTLTPPQGPPAAVQLSSA 2182
+ +T+TPP P + + + S+
Sbjct: 1637 SSITMTPPASPKSNINMYSS 1656
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 184 bits (467), Expect = 1e-45
Identities = 126/379 (33%), Positives = 198/379 (52%), Gaps = 6/379 (1%)
Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
+ +K LL + ++++ NE G TPLM AA G++E+ + L+ +GA N + +AL
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD-NWTALI 76
Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
A +GH+ +V LL+ G + EH+ TALM AC G +V LLL GA ++
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
P+ AA GH ++ LL++ GA + + G TPL+ AAR+GH E V LLA GA++
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 498 NAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYL 554
+ Q TAL +A GG+++ ++K ++ L +T LM AS+EGH E+V+ L
Sbjct: 197 D-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614
L +G V+ +GDT L A GH ++ LLQ AD++ + +T L A G+
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
V+ ++ + T + + ++ A ++ VVELLL GA + K G T L
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIK-ATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
Query: 675 AAKGGHTNVVSYLLDYPNN 693
A +G + LL P +
Sbjct: 375 AIRGRSRKLAELLLRNPKD 393
Score = 169 bits (427), Expect = 4e-41
Identities = 119/376 (31%), Positives = 188/376 (50%), Gaps = 6/376 (1%)
Query: 288 VKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAAS 347
+K LL DV+ ++ G T L A G ++IVK L+ GAN + + T L+ A+
Sbjct: 21 LKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASK 80
Query: 348 AGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHT 407
GHV + LL G + H + +AL ACYKG D+V LL GA+
Sbjct: 81 EGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEV 467
++ A GH ++ LLL +GA+VN +PL AA GH+E L+ GA++++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 468 NDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKA 527
T L+ A + G+ + V +L + N+N T++ TAL +A G +E+ L+ A
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNL-TDKDGNTALMIASKEGHTEIVQDLLDA 258
Query: 528 GADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
G + + T L+ A + GH+E+V+ LL A++ TAL +A E G+ +
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMV 318
Query: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
+LQ D E ++ G TPL+KA + ++ V+ L+ KGA V+ D T + +A
Sbjct: 319 RDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD-TPLHIAIR 377
Query: 645 GGHLAVVELLLAHGAD 660
G + ELLL + D
Sbjct: 378 GRSRKLAELLLRNPKD 393
Score = 166 bits (419), Expect = 4e-40
Identities = 122/357 (34%), Positives = 179/357 (50%), Gaps = 12/357 (3%)
Query: 1027 SQTTSNVASQSMPPVYPSV-----DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKI 1081
SQ+ N + P ++ D+D E T L +A G+ E+V LI A
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQ-TPLMIAAEQGNLEIVKELIKNGANC 64
Query: 1082 EHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLL 1141
D +T LI A+ GHV +VE LL G ++E + T L AC GR +VV+LL
Sbjct: 65 NLEDLDNWTALISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYKGRTDVVELL 123
Query: 1142 LARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNG 1201
L+ GAN + P+ AA G+ +I+ +LL GA++N K G +PL+ AA G
Sbjct: 124 LSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN--CSDKYGTTPLVWAARKG 181
Query: 1202 HVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261
H+ VK LL MG+D++ Q N TAL +A G + V +L R NV K G T L
Sbjct: 182 HLECVKHLLAMGADVD-QEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTAL 240
Query: 1262 MEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVR 1321
M A+ G+ E+ + LLD G VN P S DT L A GH + L+ + A ID+R
Sbjct: 241 MIASKEGHTEIVQDLLDAGTYVNIP--DRSGDTVLIGAVRGGHVEIVRALLQKYADIDIR 298
Query: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
+ T L+ A G+ +V+ ++Q D + TPL+ A + +++VV+ L+
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLL 355
Score = 138 bits (347), Expect = 8e-32
Identities = 102/310 (32%), Positives = 161/310 (51%), Gaps = 9/310 (2%)
Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
++ ++ LLE D + + + T LM A G++E+ + L+ +GA N+ + L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
A+ GHV + L++ G NLE + G+T LM A +G ++V LLL+ GAN + T
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSV-TGL 135
Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCS-----TPLMEASQEGHLELVKYLLASG 558
+ A G +++ L++ GA ++ CS TPL+ A+++GHLE VK+LLA G
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGA--KVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
A+V A TAL A + G+T +L+ ++ + G T LM A++ GH VQ
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
L+ G VN + D TV+ A GGH+ +V LL AD R +D T L A +
Sbjct: 254 DLLDAGTYVNIPDRSGD-TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEK 312
Query: 679 GHTNVVSYLL 688
G+ +V +L
Sbjct: 313 GNATMVRDIL 322
Score = 133 bits (335), Expect = 2e-30
Identities = 108/354 (30%), Positives = 179/354 (50%), Gaps = 17/354 (4%)
Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPL 1159
++ ++ LL+K D++ ++E TPL +A G E+V L+ GAN ++ ++T L
Sbjct: 17 NIPALKALLEKCKDVDERNE-CGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTAL 75
Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
A+ G+V+I++ LL G + R G + LM A G V+LLL G++ +
Sbjct: 76 ISASKEGHVHIVEELLKCGVNLEHRDMG--GWTALMWACYKGRTDVVELLLSHGANPSV- 132
Query: 1220 IETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLL 1277
T + + A +G A++V LLL A V K G TPL+ AA G+ E + LL
Sbjct: 133 --TGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
GADV+ S TAL +A G+ + + ++ R ++++ +K GNT L +AS GH
Sbjct: 191 AMGADVDQEGANSM--TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGH 248
Query: 1338 FDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK---EVNQFPSDIECMRYI 1394
++VQ L+ AG V+ D T L+ A R GHV++V+ L++ +++ D + Y
Sbjct: 249 TEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYW 308
Query: 1395 A----TITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREES 1444
A T + +C+ E K + +A K +I + EL L+K + S
Sbjct: 309 AVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVS 362
Score = 122 bits (305), Expect = 6e-27
Identities = 88/284 (30%), Positives = 142/284 (50%), Gaps = 2/284 (0%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
+L AC G + V LL G + + + A G+ ++ +LL A V +
Sbjct: 107 ALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKV-NC 165
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
+K TPL+ A+ G+L+ VK LL ADV+ + A TAL A GG+ VK +L
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKR 225
Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM 387
N+ +++G+T LM A+ GH E+ + LLD G +N + ++ L A GH+++
Sbjct: 226 NPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI-PDRSGDTVLIGAVRGGHVEI 284
Query: 388 VRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAAC 447
VR LL+ AD + + + TAL A G+ + R +L + E+PL A
Sbjct: 285 VRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATK 344
Query: 448 GGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
++E+ LL+++GA + V+ +G TPL A R ++ LLL
Sbjct: 345 MRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLL 388
Score = 121 bits (304), Expect = 8e-27
Identities = 94/270 (34%), Positives = 136/270 (50%), Gaps = 9/270 (3%)
Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERT 1121
A GH ++V +L+ AK+ DK G TPL+ AA GH+ V+ LL G D++ + +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
T L +A GG + V +L R N + T L +A+ G+ I++ LL+AG +
Sbjct: 204 M-TALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
N + G + L+ A GHV V+ LL +DI+ + + N+ TAL A +G A +V
Sbjct: 263 N--IPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVR 319
Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
+L + E K G TPL++A EV +LLDKGA V+A V DT L IA
Sbjct: 320 DILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIR 377
Query: 1302 KGHYKFCELLIHR---GAHIDVRNKKGNTP 1328
K ELL+ G + NK G TP
Sbjct: 378 GRSRKLAELLLRNPKDGRLLYRPNKAGETP 407
Score = 99.0 bits (245), Expect = 5e-20
Identities = 73/198 (36%), Positives = 98/198 (49%), Gaps = 4/198 (2%)
Query: 500 QTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLA 556
+ E +T L +A G E+ LIK GA+ +L T L+ AS+EGH+ +V+ LL
Sbjct: 33 ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLK 92
Query: 557 SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
G N+ G TAL +AC G TDV ++LL GA+ P++ AA GH
Sbjct: 93 CGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADI 152
Query: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
V L+ GA VN + T + A GHL V+ LLA GAD + T LI A
Sbjct: 153 VHLLLQNGAKVN-CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAV 211
Query: 677 KGGHTNVVSYLLDYPNNV 694
KGG+T V +L NV
Sbjct: 212 KGGYTQSVKEILKRNPNV 229
Score = 81.6 bits (200), Expect = 9e-15
Identities = 61/194 (31%), Positives = 103/194 (53%), Gaps = 5/194 (2%)
Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG 1112
+N TAL +A GG+ + V ++ R+ + DK G T L++A+ GH +V+ LLD G
Sbjct: 201 ANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT 260
Query: 1113 DIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 1172
+ +R+ DT L A GG E+V LL + A+ + R + T L A G +++
Sbjct: 261 YVNI-PDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVR 319
Query: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
+L + T K G +PL+ A ++ V+LLLD G+ ++A ++ +T L +A
Sbjct: 320 DILQCNPDTEICT--KDGETPLIKATKMRNIEVVELLLDKGAKVSA-VDKKGDTPLHIA- 375
Query: 1233 FQGRAEVVSLLLDR 1246
+GR+ ++ LL R
Sbjct: 376 IRGRSRKLAELLLR 389
Score = 67.8 bits (164), Expect = 1e-10
Identities = 46/145 (31%), Positives = 71/145 (48%), Gaps = 1/145 (0%)
Query: 544 QEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603
+E ++ +K LL +V G T L A E G+ ++ L++ GA+ E T
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 604 PLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTH 663
L+ A++ GH+ V+ L+ G N+ T + AC G VVELLL+HGA+P+
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGG-WTALMWACYKGRTDVVELLLSHGANPSV 132
Query: 664 RLKDGSTMLIEAAKGGHTNVVSYLL 688
+I AA GH ++V LL
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLL 157
Score = 64.7 bits (156), Expect = 1e-09
Identities = 51/168 (30%), Positives = 82/168 (48%), Gaps = 6/168 (3%)
Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
P+V++ T+ + +TAL +A GH E+V L+ + D+ G T LI A GHV
Sbjct: 227 PNVNL---TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283
Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
+V LL K DI+ + + K T L A G +V +L + E TPL A
Sbjct: 284 IVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKA 342
Query: 1163 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
+ ++++LL+ GA++++ K G +PL +A +LLL
Sbjct: 343 TKMRNIEVVELLLDKGAKVSA--VDKKGDTPLHIAIRGRSRKLAELLL 388
Score = 36.2 bits (82), Expect = 0.42
Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 1/96 (1%)
Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
GQ + +L A G+ VR +L T++GE+ L A E+ ++LL
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
Query: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297
A V KGD TPL A G + +LLL + D
Sbjct: 359 AKVSAVDKKGD-TPLHIAIRGRSRKLAELLLRNPKD 393
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 180 bits (456), Expect = 2e-44
Identities = 146/497 (29%), Positives = 235/497 (47%), Gaps = 29/497 (5%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAM--HANVED 266
L A + AV+ L+ VN + ++ L +A + + A+V++ + NV D
Sbjct: 53 LHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD 112
Query: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
RG + T L A+ G++++V LLL A++N+ AL +A G +D+V +L+N
Sbjct: 113 RGGR---TALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
GA + ++ G+TPL AAS G + V + LL+ G I+ N + +AL +ACY G
Sbjct: 170 HGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDA 228
Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVA-RLLLDSGAQVNMPADSFESPLTLA 445
+V L++ GA+ + T L A H + LL+++GA VN+ + +SPL +
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
Query: 446 ACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQ 505
A G + LI+ G ++ V+ +G TPL AAR GHE ++ L GA+ A+
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS 347
Query: 506 ETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVH 562
L LA S+ L+ +G +I+ T L A+ G++E +K L +SGA+ H
Sbjct: 348 MFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH 407
Query: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
G T L YA N H + L+ GA++ + GRT L AA +
Sbjct: 408 KKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA------------A 455
Query: 623 KGANVNRATANNDHTVVSLACAGGHL------AVVELLLAHGADPTHRLKDGSTMLIEAA 676
+ N+ N H L +E LL + A+P+ R K+G + AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
Query: 677 KGGHTNVVSYLLDYPNN 693
GH + LL+ N+
Sbjct: 516 AYGHRQCLELLLERTNS 532
Score = 170 bits (430), Expect = 2e-41
Identities = 137/457 (29%), Positives = 221/457 (48%), Gaps = 8/457 (1%)
Query: 224 LLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGG 283
L+ + VN E + L +A G E+ ++L+ A V + N +TPL A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMW-LTPLHRAVASR 60
Query: 284 YLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLM 343
+ V++L+ H ADVN++ T L A A V +V++ +++ + G T L
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
AA GHVE+ +LL GA IN + + AL A Y GHLD+V L+ GA+ K
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRR-ALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
+ +T L A +G + V + LL+ G +++ + L +A G + LI+ GAN
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN 239
Query: 464 LEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEETQETALTLACCGGFSEVAD 522
+ + N+ G+TPL AA H + + LL+ GA++N Q+++ + A G F+ +
Sbjct: 240 VNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQ 298
Query: 523 FLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENG 579
LI+ G +I+ +TPL A++ GH L+ L SGA+ L A N
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNA 358
Query: 580 HTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVV 639
H+D LL +G +++ + GRT L AA G++ ++ L S GA+ ++ T +
Sbjct: 359 HSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD-KCGRTPL 417
Query: 640 SLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
A A H +E L+ GA+ G T L AA
Sbjct: 418 HYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA 454
Score = 167 bits (423), Expect = 1e-40
Identities = 158/559 (28%), Positives = 243/559 (43%), Gaps = 71/559 (12%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
+L A +G V V LL +G ++N ++ L A G+ ++ +L+ A V +
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
KG TPL AA+S G +++VK LL +++ + GNTAL AC G +V L++
Sbjct: 178 DKKG-YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
Query: 328 GANIEDHNENGHTPLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKE------------- 373
GAN+ N NG TPL AA++ H + +L+++GA +N S + K
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
Query: 374 -------------------SALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM 414
+ L +A GH ++ L +GAD L A +
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Query: 415 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP 474
+ H + R LL SG +++ P + L AA GG+VE LL GA+ + + G TP
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE--------------- 519
L AA H + L+ GAN+N +T++ TAL A
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
Query: 520 -------------VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHA 563
+FL++ A+ + + A+ GH + ++ LL +
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535
Query: 564 TTATGDTA--LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
+ +G T L A NGH +VLLQ+ DL+ E GRT L AA GH V+ LI
Sbjct: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
Query: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP-THRLKD--GSTMLIEAAKG 678
+ GA++ T + + GH + LLL +P +KD G T L+ A
Sbjct: 596 NPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAY 655
Query: 679 GHTNVVSYLLDYPNNVLSV 697
GH + VS LL+ NV +V
Sbjct: 656 GHIDAVSLLLEKEANVDTV 674
Score = 149 bits (377), Expect = 3e-35
Identities = 124/425 (29%), Positives = 195/425 (45%), Gaps = 7/425 (1%)
Query: 274 TPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED 333
TPL A+ G +I++LL+L A VN++ T L A A + V+VL+ A++
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77
Query: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
++N TPL AA+ V+ A V++ + +N S+ +AL A GH++MV LL
Sbjct: 78 RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV-SDRGGRTALHHAALNGHVEMVNLLLA 136
Query: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
GA+ + AL A GH++V LL++ GA+V +PL AA G + +
Sbjct: 137 KGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINV 196
Query: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
L+ G ++E+N G T L A G + +V L+ GAN+N Q T L A
Sbjct: 197 VKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAA 255
Query: 514 CGGFSEVA-DFLIKAGADIELGC---STPLMEASQEGHLELVKYLLASGANVHATTATGD 569
+ + L+ GAD+ + +PL + G + L+ +G + G+
Sbjct: 256 ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN 315
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
T L A GH + + L +GAD PL AA H + L+S G ++
Sbjct: 316 TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID- 374
Query: 630 ATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
T + A AGG++ ++LL + GAD + K G T L AA H + + L+
Sbjct: 375 TPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVT 434
Query: 690 YPNNV 694
NV
Sbjct: 435 TGANV 439
Score = 142 bits (359), Expect = 3e-33
Identities = 108/322 (33%), Positives = 158/322 (49%), Gaps = 40/322 (12%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L A A EE V VLI A + RDK TPL +AA V E+++ +
Sbjct: 51 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNV 110
Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
S+R T L A G E+V+LLLA+GAN + D L AA G+++++ +L+N
Sbjct: 111 -SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLIN 169
Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
GAE+ + K G +PL AA NG + VK LL++G +I+ +I NTAL +AC+ G+
Sbjct: 170 HGAEVTCK--DKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQ 226
Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
VV+ L+D GA+VN P ++ T L
Sbjct: 227 DAVVN---------------------------------ELIDYGANVNQPN--NNGFTPL 251
Query: 1297 TIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAAD 1355
AA H C ELL++ GA +++++K G +PL + + G F Q L+Q G ++D D
Sbjct: 252 HFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
Query: 1356 NRKITPLMSAFRKGHVKVVQYL 1377
TPL A R GH ++ L
Sbjct: 312 KDGNTPLHVAARYGHELLINTL 333
Score = 141 bits (355), Expect = 9e-33
Identities = 117/402 (29%), Positives = 186/402 (46%), Gaps = 8/402 (1%)
Query: 291 LLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 349
+L+H DVN+ + T L A G +I+++L+ GA + + TPL A ++
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 350 HVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
E +VL+ H A +N + ++ L +A + ++ + TAL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNW-QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTAL 119
Query: 410 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVND 469
A ++GHVE+ LLL GA +N L AA GH+++ ALLI GA + +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 470 EGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
+GYTPL AA G +V LL G I+ + TAL +AC G V + LI GA
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 530 DIELGCS---TPLMEASQEGHLEL-VKYLLASGANVHATTATGDTALTYACENGHTDVAD 585
++ + TPL A+ H L ++ L+ +GA+V+ + G + L +G +
Sbjct: 239 NVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Query: 586 VLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAG 645
L+Q G +++ + G TPL AAR GH + L + GA+ + ++ + LA
Sbjct: 299 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP-LHLAALN 357
Query: 646 GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
H LL+ G + K G T L AA GG+ + L
Sbjct: 358 AHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL 399
Score = 138 bits (348), Expect = 6e-32
Identities = 142/515 (27%), Positives = 228/515 (44%), Gaps = 25/515 (4%)
Query: 190 LTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAG 249
L + + H + L A ++ + + L+ G +VNE + G + L A ++
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASD 457
Query: 250 YYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTAL 309
+L H N E+ ++ A ++ LL +DA+ + + G ++
Sbjct: 458 MDRNKTILGNAHDNSEELERARELKEKEATLC------LEFLLQNDANPSIRDKEGYNSI 511
Query: 310 TYACAGGFVDIVKVLLNEGANIEDHNENGHT--PLMEAASAGHVEVARVLLDHGAGINTH 367
YA A G +++LL + + +++G T PL AA GH + VLL ++
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 368 SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLL- 425
+E +AL LA +KGH + V L+ GA K + T L + ++GH RLLL
Sbjct: 572 -DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Query: 426 --DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGH 483
D+ V++ ++PL LA GH++ +LL+E+ AN++ V+ G T L GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690
Query: 484 EEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS------T 537
EE V +LL Q +I + + T L A G + L++ E C T
Sbjct: 691 EECVQMLLEQEVSILCK-DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYT 749
Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA--GADLE 595
PL A G+ ++ LL T L A N H + A +LL A + +
Sbjct: 750 PLHWACYNGNENCIEVLLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
Query: 596 HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLL 655
+ GRTPL AA A H+ +Q L+ A VN A N+ T + +A G V++L+
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVN-AVDNSGKTALMMAAENGQAGAVDILV 867
Query: 656 -AHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
+ AD T + KD +T L A GH +LD
Sbjct: 868 NSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 134 bits (337), Expect = 1e-30
Identities = 119/408 (29%), Positives = 183/408 (44%), Gaps = 32/408 (7%)
Query: 266 DRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
D +K T L AA++GG ++ +KLL AD + + G T L YA A ++ L+
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Query: 326 NEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN--------EFKESALT 377
GAN+ + ++ G T L AA A ++ + +L N H N E KE T
Sbjct: 434 TTGANVNETDDWGRTALHYAA-ASDMDRNKTILG-----NAHDNSEELERARELKEKEAT 487
Query: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
L + FLL+ A+ + E + ++ A GH + LLL+ +DS
Sbjct: 488 LC--------LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
Query: 438 --FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
+SPL LAA GH + +L++ +L+ +++G T L AA +GH E V L+ GA
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA 599
Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL------GCSTPLMEASQEGHLE 549
+I + T+ T L + G + L++ + E TPLM A GH++
Sbjct: 600 SIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHID 659
Query: 550 LVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
V LL ANV G TAL GH + +LL+ + + GRTPL AA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Query: 610 RAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLL 655
GH + L+ + N +T + AC G+ +E+LL
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 129 bits (325), Expect = 3e-29
Identities = 139/522 (26%), Positives = 220/522 (42%), Gaps = 43/522 (8%)
Query: 222 RKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASS 281
RKLL G ++ + G + L A + G E ++L + A+ + G TPL A++
Sbjct: 364 RKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGR-TPLHYAAA 422
Query: 282 GGYLDIVKLLLLHDADVNSQSATGNTALTYACA----------GGFVD------------ 319
+ ++ L+ A+VN G TAL YA A G D
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
Query: 320 ------IVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH-GAGINTHSNEFK 372
++ LL AN ++ G+ + AA+ GH + +LL+ +G +
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
Query: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
+S L LA Y GH + LL++ D + + ++ TAL A GH E L++ GA +
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602
Query: 433 MPAD-SFESPLTLAACGGHVELAALLIERGANLEEVN---DEGYTPLMEAAREGHEEMVA 488
+ + + +PL + GH LL+E N E V+ +G TPLM A GH + V+
Sbjct: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662
Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQE 545
LLL + AN++ + TAL G E L++ I S TPL A+
Sbjct: 663 LLLEKEANVDT-VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAAR 721
Query: 546 GHLELVKYLLA---SGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
GH + LL S + G T L +AC NG+ + +VLL+ +
Sbjct: 722 GHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF- 780
Query: 603 TPLMKAARAGH-LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADP 661
TPL A H C L + +++ + T + A H+ ++LLL H A
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 662 THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVS 703
G T L+ AA+ G V L++ L+V D++
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN 882
Score = 120 bits (301), Expect = 2e-26
Identities = 113/357 (31%), Positives = 158/357 (44%), Gaps = 24/357 (6%)
Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
L LA GH + + VL+ ++ RD+KG T L LAA GH VE L++ G I +
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
TK TPL + G + LLL N E +V D TPL LA + G+++ + +LL
Sbjct: 606 NVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLL 665
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
E N T LG + L M GH V++LL+ I + ++ T L A +G
Sbjct: 666 E--KEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK-DSRGRTPLHYAAARG 722
Query: 1236 RAEVVSLLLDRKANVE---HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
A +S LL + E + G TPL A G VLL++ P
Sbjct: 723 HATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-- 780
Query: 1293 DTALTIAADKGHYKFCELLIHR--GAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
T L A H LL+ + + R+ KG TPL A+ H + +QLL++ A
Sbjct: 781 -TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
Query: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLKKCH 1407
V+A DN T LM A G V L VN +D+ T+ DK+L H
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDIL---VNSAQADL-------TVKDKDLNTPLH 886
Score = 108 bits (269), Expect = 9e-23
Identities = 107/384 (27%), Positives = 164/384 (42%), Gaps = 64/384 (16%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
+TAL +AC G + +V+ LI A + + GFTPL AA + H + +E+L++ G D+
Sbjct: 215 NTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADV 274
Query: 1115 EAQSERTK--------------------------------DTPLSLACSGGRQEVVDLLL 1142
QS+ K +TPL +A G + +++ L
Sbjct: 275 NIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Query: 1143 ARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
GA+ + PL LAA + + + LL++G EI+ T K G + L AA G+
Sbjct: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID--TPDKFGRTCLHAAAAGGN 392
Query: 1203 VPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
V +KLL G+D + + + R T L A + L+ ANV G T L
Sbjct: 393 VECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALH 451
Query: 1263 EAASGGY----------------AEVGRVLLDKGADV------NAPPVPSSRD----TAL 1296
AA+ E R L +K A + PS RD ++
Sbjct: 452 YAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSI 511
Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNT--PLWLASNGGHFDVVQLLVQAGADVDAA 1354
AA GH + ELL+ R + G T PL LA+ GH +++L+Q+ D+D
Sbjct: 512 HYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIR 571
Query: 1355 DNRKITPLMSAFRKGHVKVVQYLV 1378
D + T L A KGH + V+ L+
Sbjct: 572 DEKGRTALDLAAFKGHTECVEALI 595
Score = 101 bits (252), Expect = 8e-21
Identities = 90/316 (28%), Positives = 151/316 (47%), Gaps = 12/316 (3%)
Query: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK--GGDIEAQSERTKDTPLSLACS 1131
L+ DA RDK+G+ + AA GH +E+LL++ G E+ S TK +PL LA
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATK-SPLHLAAY 551
Query: 1132 GGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGI 1191
G + +++LL + + R+ T L LAA G+ ++ L+N GA I + +
Sbjct: 552 NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVK-DNVTKR 610
Query: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINA--QIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
+PL + +NGH ++LLL++ + A + T L LA G + VSLLL+++AN
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
V+ G T L G+ E ++LL++ +V+ S T L AA +GH +
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGHATWLS 728
Query: 1310 LLIHRGAHID---VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAF 1366
L+ + ++ +G TPL A G+ + +++L++ N TPL A
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN-PFTPLHCAI 787
Query: 1367 RKGHVKVVQYLVKEVN 1382
H L+ ++
Sbjct: 788 INDHGNCASLLLGAID 803
Score = 100 bits (249), Expect = 2e-20
Identities = 72/222 (32%), Positives = 117/222 (52%), Gaps = 5/222 (2%)
Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
TPL +AA G II++L+ +GA +N++ + ++PL A + AV++L+ +D+
Sbjct: 18 TPLHVAAFLGDAEIIELLILSGARVNAK--DNMWLTPLHRAVASRSEEAVQVLIKHSADV 75
Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
NA+ + N T L +A + +++ ++V + G T L AA G+ E+ +L
Sbjct: 76 NAR-DKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
L KGA++NA R AL AA GH LLI+ GA + ++KKG TPL A++ G
Sbjct: 135 LAKGANINAFDKKDRR--ALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG 192
Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
+VV+ L+ G ++D + T L A G VV L+
Sbjct: 193 QINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELI 234
Score = 89.4 bits (220), Expect = 4e-17
Identities = 66/206 (32%), Positives = 104/206 (50%), Gaps = 5/206 (2%)
Query: 1173 ILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLAC 1232
+L++ ++N+ K +PL +AA G ++LL+ G+ +NA+ + T L A
Sbjct: 1 MLIHKTEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAK-DNMWLTPLHRAV 57
Query: 1233 FQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1292
E V +L+ A+V R K TPL AA+ + V++ + VN
Sbjct: 58 ASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSD--RGG 115
Query: 1293 DTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
TAL AA GH + LL+ +GA+I+ +KK L A+ GH DVV LL+ GA+V
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175
Query: 1353 AADNRKITPLMSAFRKGHVKVVQYLV 1378
D + TPL +A G + VV++L+
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLL 201
Score = 89.0 bits (219), Expect = 6e-17
Identities = 77/250 (30%), Positives = 121/250 (48%), Gaps = 14/250 (5%)
Query: 1044 SVDIDAHTESNHDTALTLACAG-------GHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
+V + E+N DT L C GHEE V +L+ ++ I +D +G TPL AA
Sbjct: 660 AVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAA 719
Query: 1097 TAGHVGVVEILLDKGGDIE--AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
GH + LL E + TPL AC G + +++LL + ++ +
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-N 778
Query: 1155 DYTPLSLAASGGYVNIIKILLNA-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG 1213
+TPL A + N +LL A + I S K G +PL AA HV ++LLL
Sbjct: 779 PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK-GRTPLRAAAFADHVECLQLLLRHS 837
Query: 1214 SDINAQIETNRNTALTLACFQGRAEVVSLLLD-RKANVEHRAKTGLTPLMEAASGGYAEV 1272
+ +NA ++ + TAL +A G+A V +L++ +A++ + K TPL A S G+ +
Sbjct: 838 APVNA-VDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKC 896
Query: 1273 GRVLLDKGAD 1282
++LDK D
Sbjct: 897 ALLILDKIQD 906
Score = 87.8 bits (216), Expect = 1e-16
Identities = 82/279 (29%), Positives = 124/279 (44%), Gaps = 9/279 (3%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
++ T L LA A GH + VS+L+ ++A ++ D G T L GH V++LL++
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKE---HRNVSDYTPLSLAASGGYV 1168
I + R + TPL A + G + LL ++E ++ YTPL A G
Sbjct: 702 VSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNE 760
Query: 1169 NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINAQIETNRNTA 1227
N I++LL G+ +PL A +N H LLL + S I + + T
Sbjct: 761 NCIEVLLEQKC-FRKFIGNP--FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
Query: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287
L A F E + LLL A V +G T LM AA G A +L++ A +
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN-SAQADLTV 876
Query: 1288 VPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGN 1326
+T L +A KGH K L++ + + N+K N
Sbjct: 877 KDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915
Score = 71.2 bits (173), Expect = 1e-11
Identities = 69/285 (24%), Positives = 119/285 (41%), Gaps = 38/285 (13%)
Query: 223 KLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSG 282
++ D +V+ +G++ L LA + G+ + +LL ANV+ G T L
Sbjct: 630 EIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMT 688
Query: 283 GYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIED---HNENGH 339
G+ + V++LL + + + + G T L YA A G + LL + ED + G+
Sbjct: 689 GHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGY 748
Query: 340 TPLMEAASAGHVEVARVLLD---------------HGAGINTHSN--------------- 369
TPL A G+ VLL+ H A IN H N
Sbjct: 749 TPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVS 808
Query: 370 ---EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD 426
+ + L A + H++ ++ LL A + TALM A +G +L++
Sbjct: 809 CRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Query: 427 SG-AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE 470
S A + + +PL LA GH + A L++++ + +N++
Sbjct: 869 SAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 53.9 bits (128), Expect = 2e-06
Identities = 73/294 (24%), Positives = 112/294 (38%), Gaps = 78/294 (26%)
Query: 192 RMKAENSHNAGQVDTRS------LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLA 245
R+ E + N VD + L A + G ++AV LL++ +V+ G + L
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRG 685
Query: 246 CSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL---LHDADVNSQS 302
G+ E Q+LL ++ + ++G TPL A++ G+ + LL L + D +
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGR-TPLHYAAARGHATWLSELLQMALSEEDCCFKD 744
Query: 303 ATGNTALTYACAGGFVDIVKVLLNEG---------------ANIEDH------------- 334
G T L +AC G + ++VLL + A I DH
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDS 804
Query: 335 ------NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK---------------- 372
++ G TPL AA A HVE ++LL H A +N N K
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 864
Query: 373 -----------------ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTAL 409
+ L LAC KGH +L+ D E +E + AL
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD-ESLINEKNNAL 917
Score = 48.5 bits (114), Expect = 8e-05
Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 9/108 (8%)
Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
+LIH+ ++ + + TPL +A+ G ++++LL+ +GA V+A DN +TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 1370 HVKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
+ VQ L+K +VN + + ++A K +C E I+
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAA------ANKAVKCAEVII 102
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 169 bits (427), Expect = 4e-41
Identities = 163/602 (27%), Positives = 258/602 (42%), Gaps = 98/602 (16%)
Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
D L +A DV VR LL + ++N +E + L A G + Q+LL ANV
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
+ +TPL A++ ++ LLL H ADVN++ T L A A + L
Sbjct: 68 NAKDTLW-LTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Query: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
+++ + +G + L A +GH+E +LL+ GA +N + ++ L A + GH
Sbjct: 127 APLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGH 185
Query: 385 LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 444
L++++ L+ GAD K + + L A G +EV + LL GA+++ P + L +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHI 245
Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEM-VALLLAQGANINAQTEE 503
A G +A L+ GAN+ + ND+G+TPL AA + + + LL+ GA++N Q++E
Sbjct: 246 ACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKE 305
Query: 504 TQETALTLACCGGFSEVADFLIKAGADIELG---CSTPLMEASQEGHLELVKYLLASGA- 559
+ A G F+ + LI+ G++I+ +TPL A++ GH L+ L+ +GA
Sbjct: 306 GKSPLHMAAIHGRFTR-SQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364
Query: 560 -----------------------------------------NVHATTA---------TGD 569
N H +A G
Sbjct: 365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGR 424
Query: 570 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNR 629
T L A G+ + ++LL +GADL + GRTPL AA G L++ GA VN
Sbjct: 425 TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNE 484
Query: 630 -----------ATANNDHTVVSLACAGGHLA----------------VVELLLAHGADPT 662
A A++ + H A +E LL +GADP+
Sbjct: 485 ADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPS 544
Query: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQSQVPRVPTHT 722
R + G T + AA G+ + LL+ N L DV +S +P P H
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE----DV---------ESTIPVSPLHL 591
Query: 723 LA 724
A
Sbjct: 592 AA 593
Score = 143 bits (360), Expect = 2e-33
Identities = 162/634 (25%), Positives = 249/634 (39%), Gaps = 106/634 (16%)
Query: 123 EIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTAD-----GKAFADPEVLRRLTS 177
E+ A GADL D + L AA G++ G +P
Sbjct: 187 EVLKLLVARGADLGCKDRKGYGLLHT---AAASGQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Query: 178 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAE----ACSDGDVNAVRKLLDEGRSVNE 233
++C L + A A+ + A N Q + + A S + L++ G VN
Sbjct: 244 HIACYLGQDAVAIELVNA--GANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 234 HTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL- 292
++EG+S L +A G + +Q+L+ + + D +K TPL A+ G+ ++ L+
Sbjct: 302 QSKEGKSPLHMAAIHGRFTRSQILIQNGSEI-DCADKFGNTPLHVAARYGHELLISTLMT 360
Query: 293 ---------LHDA-----------------------------------------DVNSQS 302
+HD D+N+
Sbjct: 361 NGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPD 420
Query: 303 ATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362
G T L A +GG V+ + +LL+ GA++ ++ G TPL AA+ G + A L+ GA
Sbjct: 421 NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGA 480
Query: 363 GIN----------------------------THSNEFKESALTLACYKGHLDMVRFLLEA 394
G+N +H E ++ L + K + FLL+
Sbjct: 481 GVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAE-EDEPLKESRRKEAFFCLEFLLDN 539
Query: 395 GADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF--ESPLTLAACGGHVE 452
GAD + + +TA+ A G+ + LLL+ +S SPL LAA GH E
Sbjct: 540 GADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCE 599
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
L E NL+ + +G T L A G E V +L A GA+ + + + T L A
Sbjct: 600 ALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAA 659
Query: 513 CCGGFSEVADFLIKAG--ADI----ELGCSTPLMEASQEGHLELVKYLLASGANVHATTA 566
G ++ LI +G ADI + TPLM A GH++ V LL G+ A
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADL 719
Query: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
G TAL G D LL A + GRTP+ A+ GH ++ L+ +
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
Query: 627 VNRATANNDHTVVS---LACAGGHLAVVELLLAH 657
+ A D++ S A GH +ELLL H
Sbjct: 780 TDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 142 bits (358), Expect = 4e-33
Identities = 161/543 (29%), Positives = 230/543 (42%), Gaps = 60/543 (11%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L A + G + V+ LL G ++E G + L +AC G +A L+ ANV
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
+KG TPL A S+ G L ++LL+ + ADVN QS G + L A G ++L+
Sbjct: 270 DKG-FTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
G+ I+ ++ G+TPL AA GH + L+ +GA L LA G D
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD-TARRGIHDMFPLHLAVLFGFSD 386
Query: 387 MVRFLLEAG--------ADQEH---------KTDEM-HTALMEACMDGHVEVARLLLDSG 428
R LL +G EH D + T L A G+VE LLL SG
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446
Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-------RE 481
A + +PL AA G + A L+ GA + E + +G +PL AA E
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506
Query: 482 GH-------EE--------------MVALLLAQGANINAQTEETQETALTLACCGGFSEV 520
H EE + LL GA+ + + + TA+ A G +
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGY-TAVHYAAAYGNRQN 565
Query: 521 ADFLIKAG----ADIELGCS-TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYA 575
+ L++ D+E +PL A+ GH E +K L + N+ G TAL A
Sbjct: 566 LELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625
Query: 576 CENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAARAGHLCTVQFLISKG--ANVNRATA 632
E G T+ +VL GA L E + TPL AA +GH ++ LI G A++
Sbjct: 626 TERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMD 685
Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPN 692
T + LA GH+ V LLL G+ G T L A G + ++ LLD+
Sbjct: 686 AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDA 745
Query: 693 NVL 695
VL
Sbjct: 746 FVL 748
Score = 127 bits (318), Expect = 2e-28
Identities = 151/566 (26%), Positives = 233/566 (41%), Gaps = 79/566 (13%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L A S G+V + LL G + + G + L A + G Y+ A L+ A V +
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Query: 269 NKGDITPLMAASSGGY---------------------------LDIVKLLLLHDADVNSQ 301
KG AA+S Y ++ LL + AD + +
Sbjct: 487 CKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLR 546
Query: 302 SATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGH--TPLMEAASAGHVEVARVLLD 359
G TA+ YA A G +++LL N + E+ +PL AA GH E + L +
Sbjct: 547 DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAE 606
Query: 360 HGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHV 418
++ ++ + +AL LA +G + V L GA K + T L A GH
Sbjct: 607 TLVNLDVRDHKGR-TALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665
Query: 419 EVARLLLDSG--AQVNMPADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475
+ LL+DSG A + D++ ++PL LA GHV+ LL+E+G+ + + G T L
Sbjct: 666 DSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Query: 476 MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------- 528
A G E+ +A LL A + + + + T + LA G + V L++A
Sbjct: 726 HRGAVTGCEDCLAALLDHDAFVLCRDFKGR-TPIHLASACGHTAVLRTLLQAALSTDPLD 784
Query: 529 ADIELGCSTPLMEASQEGHLELVKYLL--------------------------------- 555
A ++ +P+ AS GH + ++ LL
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLG 844
Query: 556 ASGAN-VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHL 614
A GA V++ A G T L A + +LLQ A++ GRT LM AA G
Sbjct: 845 ALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQT 904
Query: 615 CTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTM--- 671
V+FL+ +G N +T + LAC+ GH ++LA D S +
Sbjct: 905 AAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMP 964
Query: 672 LIEAAKGGHTNVVSYLLDYPNNVLSV 697
L AA+ G +VV LL + VL+V
Sbjct: 965 LHIAARNGLASVVQALLSHGATVLAV 990
Score = 122 bits (307), Expect = 3e-27
Identities = 102/342 (29%), Positives = 165/342 (48%), Gaps = 36/342 (10%)
Query: 1069 ELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSL 1128
E V L+++ I D++ TPL AA G V ++++LL G ++ A+ TPL
Sbjct: 22 EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL-TPLHR 80
Query: 1129 ACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSK 1188
A + ++V+ LLLA A+ R+ TPL +AA+ + L + +N +
Sbjct: 81 AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLN--VADR 138
Query: 1189 LGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKA 1248
G S L A +GH+ V LLL+ G+ +N + R L A F G EV+ LL+ R A
Sbjct: 139 SGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP-LHWAAFLGHLEVLKLLVARGA 197
Query: 1249 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV-------------------- 1288
++ + + G L AA+ G EV + LL GA+++ P
Sbjct: 198 DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIE 257
Query: 1289 ----------PSSRD-TALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
P+ + T L +AA + C ELL++ GA ++ ++K+G +PL +A+ G
Sbjct: 258 LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHG 317
Query: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
F Q+L+Q G+++D AD TPL A R GH ++ L+
Sbjct: 318 RFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Score = 112 bits (279), Expect = 6e-24
Identities = 118/415 (28%), Positives = 183/415 (44%), Gaps = 21/415 (5%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +G A++ L + +++ +G + L LA G E +VL A A+ + K
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Query: 272 DITPLMAASSGGYLDIVKLLLLHD--ADVNS-QSATGNTALTYACAGGFVDIVKVLLNEG 328
TPL AA++ G+ D + LL+ AD+ A G T L A G VD V +LL +G
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGHLDM 387
+ + + G T L A G + LLDH A + +FK + + LA GH +
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCR--DFKGRTPIHLASACGHTAV 769
Query: 388 VRFLLEAGADQEHKTDEM----HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
+R LL+A + + ++ + A GH + LLL+ + + F +PL
Sbjct: 770 LRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLH 828
Query: 444 LAACGGHVELAALLIER-GANLEEVND-EGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
A +L+ GA + D +G TPL AA + + +LL A +NA T
Sbjct: 829 CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA-T 887
Query: 502 EETQETALTLACCGGFSEVADFLIKAG-ADIEL---GCSTPLMEASQEGHLELVKYLLAS 557
+ T TAL A G + +FL+ G AD+ + +T L A +GH + +LA
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947
Query: 558 GAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
+ ++AT + L A NG V LL GA + E G TP + A
Sbjct: 948 TQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
Score = 103 bits (257), Expect = 2e-21
Identities = 103/371 (27%), Positives = 163/371 (43%), Gaps = 51/371 (13%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
+TAL +AC G + + L+ A + + KGFTPL +AA + + + +E+L++ G D+
Sbjct: 240 NTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADV 299
Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
QS+ K +PL +A GR +L+ G+ + + TPL +AA G+ +I L
Sbjct: 300 NYQSKEGK-SPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS------------------DI 1216
+ GA+ +R G + PL LA + G + LL G DI
Sbjct: 359 MTNGAD-TARRGIH-DMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDI 416
Query: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
N R T L A G E ++LLL A++ R K G TPL AA+ G + L
Sbjct: 417 NTPDNLGR-TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
Query: 1277 LDKGADVN----------------------APPVPSSRDTALTIAADKGHYK---FC-EL 1310
+ GA VN P PSS D + K FC E
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
Query: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADV--DAADNRKITPLMSAFRK 1368
L+ GA +R+++G T + A+ G+ ++LL++ + D ++PL A
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 1369 GHVKVVQYLVK 1379
GH + ++ L +
Sbjct: 596 GHCEALKTLAE 606
Score = 102 bits (254), Expect = 5e-21
Identities = 105/373 (28%), Positives = 154/373 (41%), Gaps = 48/373 (12%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKK---GFTPLILAATAGHVGVVEILLDKGGD 1113
T L A A GH + + +LI + + D G TPL+LA GHV V +LL+KG
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
+A R + T L G ++ + LL A R+ TP+ LA++ G+ +++
Sbjct: 714 ADAADLRGR-TALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRT 772
Query: 1174 LLNAGAEINSRTGSK--LGISPLMLAAMNGHVPAVKLLLD-------------------- 1211
LL A + G SP+ A+ GH ++LLL+
Sbjct: 773 LLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVI 832
Query: 1212 -------------MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGL 1258
+G+ I + T L A F + +LL +A V TG
Sbjct: 833 NNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGR 892
Query: 1259 TPLMEAASGGYAEVGRVLLDKG-ADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
T LM AA G LL +G AD+ + +++TAL +A KGH K C L+I
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTV--LDENKNTALHLACSKGHEK-CALMILAETQ 949
Query: 1318 ----IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP-LMSAFRKGHVK 1372
I+ N PL +A+ G VVQ L+ GA V A D TP L A K
Sbjct: 950 DLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVAD 1009
Query: 1373 VVQYLVKEVNQFP 1385
+ ++ + FP
Sbjct: 1010 CLALILSTMKPFP 1022
Score = 95.5 bits (236), Expect = 6e-19
Identities = 103/395 (26%), Positives = 155/395 (39%), Gaps = 77/395 (19%)
Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
L LA GH E + L ++ RD KG T L LA G VE+L G +
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
+ K TPL A + G + + LL+ G + +V D TPL LA G+V+ + +LL
Sbjct: 649 RKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLL 708
Query: 1176 NAG-----AEINSRTGSKLGI--------------------------SPLMLAAMNGHVP 1204
G A++ RT G +P+ LA+ GH
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTA 768
Query: 1205 AVKLLLDMG---SDINAQIETNRNTALTLACFQGRAEVVSLLLDRK-------------- 1247
++ LL ++A ++ + + + A + G + + LLL+
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPFTPLH 828
Query: 1248 --------------------ANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP 1287
V R G TPL AA R+LL A+VNA
Sbjct: 829 CAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA-- 886
Query: 1288 VPSSRDTALTIAADKGHYKFCELLIHRG-AHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346
+ TAL AA+ G E L++RG A + V ++ NT L LA + GH +++
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 1347 AGAD---VDAADNRKITPLMSAFRKGHVKVVQYLV 1378
D ++A ++ PL A R G VVQ L+
Sbjct: 947 ETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
Score = 94.4 bits (233), Expect = 1e-18
Identities = 74/228 (32%), Positives = 116/228 (50%), Gaps = 5/228 (2%)
Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
+++D PL A V ++ LL+ IN + +PL AA G VP ++LLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLM 62
Query: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
G+++NA+ +T T L A +V+ LLL A+V R K TPL AA+ +
Sbjct: 63 SGANVNAK-DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATK 121
Query: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
L + +N S +AL A GH + LL+++GA ++V +KK PL
Sbjct: 122 CAEALAPLLSSLNV--ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHW 179
Query: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
A+ GH +V++LLV GAD+ D + L +A G ++VV+YL++
Sbjct: 180 AAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR 227
Score = 87.0 bits (214), Expect = 2e-16
Identities = 85/273 (31%), Positives = 132/273 (48%), Gaps = 15/273 (5%)
Query: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY---TPLSLAASGGYVNIIKILLNA 1177
T PL A E V LL++ KE+ NV D TPL AA G V I+++LL +
Sbjct: 7 TDQPPLVQAIFSRDVEEVRSLLSQ---KENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
GA +N++ L ++PL AA + + + LLL +D+NA+ + T L +A
Sbjct: 64 GANVNAK--DTLWLTPLHRAAASRNEKVLGLLLAHSADVNAR-DKLWQTPLHVAAANRAT 120
Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
+ L +++ ++G + L A G+ E +LL+KGA +N L
Sbjct: 121 KCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNV--CDKKERQPLH 178
Query: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
AA GH + +LL+ RGA + +++KG L A+ G +VV+ L++ GA++D +
Sbjct: 179 WAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAF 238
Query: 1358 KITPLMSAFRKGHVKVVQYLVK---EVNQFPSD 1387
T L A G V LV VNQ P+D
Sbjct: 239 GNTALHIACYLGQDAVAIELVNAGANVNQ-PND 270
Score = 66.2 bits (160), Expect = 4e-10
Identities = 77/291 (26%), Positives = 111/291 (38%), Gaps = 41/291 (14%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTE----EGESLLCLACSAGYYELAQVLLAMHANV 264
LA AC G +R LL S + G S + A G+ + ++LL
Sbjct: 760 LASAC--GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLL--LHDADVNSQSATGNTALTYACAGGFVDIVK 322
GN TPL A ++LL L VNS+ A G T L A V ++
Sbjct: 818 YLEGNP--FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR 875
Query: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
+LL A + + G T LM AA G LL G T +E K +AL LAC K
Sbjct: 876 MLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK 935
Query: 383 GHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 442
GH +L D +N + + PL
Sbjct: 936 GHEKCALMILAETQDL------------------------------GLINATNSALQMPL 965
Query: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA-REGHEEMVALLLA 492
+AA G + L+ GA + V++EG+TP + A + + +AL+L+
Sbjct: 966 HIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
Score = 61.2 bits (147), Expect = 1e-08
Identities = 55/177 (31%), Positives = 82/177 (46%), Gaps = 4/177 (2%)
Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
V R KG TPL AA+ + +++LL H A+VN+ TG TAL A G V+
Sbjct: 851 VNSRDAKGR-TPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEF 909
Query: 324 LLNEG-ANIEDHNENGHTPLMEAASAGHVEVARVLL--DHGAGINTHSNEFKESALTLAC 380
LL G A++ +EN +T L A S GH + A ++L G+ +N + L +A
Sbjct: 910 LLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAA 969
Query: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADS 437
G +V+ LL GA +E HT + + V L+ S + P D+
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILSTMKPFPPKDA 1026
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 168 bits (425), Expect = 7e-41
Identities = 146/513 (28%), Positives = 231/513 (45%), Gaps = 40/513 (7%)
Query: 205 DTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANV 264
D SL +A +GD + VR L+ + VN E + L A G E+ ++L+ A V
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT-------------------- 304
+ +K +TPL A + + V++LL H ADVN++
Sbjct: 68 NAKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 305 -------------GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
G TAL +A G ++VK+LL+ GANI ++ + AA GH+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
EV ++L+ HGA + T ++ + L A G + +V++LL+ G D +T L
Sbjct: 187 EVVKLLVSHGAEV-TCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Query: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELA-ALLIERGANLEEVNDE 470
AC +G V L+D GA VN + +PL AA H L LL+ GA++ + +
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD 305
Query: 471 GYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD 530
G TPL A G ++ GA I+ + ++ T L +A G + + LI +GAD
Sbjct: 306 GKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 531 IE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
+ PL A+ G + + LL+SG ++ G T L A G+ + ++L
Sbjct: 365 TAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLL 424
Query: 588 LQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGH 647
L GAD + + GR+PL AA + + L+ GA+VN + A +
Sbjct: 425 LNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
Query: 648 LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGH 680
+E LL + A+P R K G + +A GH
Sbjct: 485 GKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517
Score = 166 bits (420), Expect = 3e-40
Identities = 164/584 (28%), Positives = 251/584 (42%), Gaps = 70/584 (11%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITP 275
G + + ++ G ++ + G + L +A G+ L L+ A+ RG G + P
Sbjct: 317 GRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG-MFP 375
Query: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHN 335
L A+ G+ D + LL D+++ G T L A AGG ++ + +LLN GA+ +
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDM----VRFL 391
+ G +PL AA+ + + L+ GA +N + E T Y D + +L
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVN----DLDERGCTPLHYAATSDTDGKCLEYL 491
Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLD----------SGAQVNMPADSFE-- 439
L A+ + + + A+ + GH +L+ SG + +D+
Sbjct: 492 LRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
SPL LAA GH + +L++ +L+ N G TPL AA +GH E V +L+ QGA+I
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 500 QTEETQETALTLACCGGFSEVADFLI-----KAGADIELGCS-TPLMEASQEGHLELVKY 553
+ + T + A G SE LI + DI+ G TPLM + GH + V
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYS 671
Query: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
LL GANV A G TAL GH + D LLQ GA GRTP+ +A GH
Sbjct: 672 LLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGH 731
Query: 614 LCTVQFLISKGANV--NRATA-NNDHTVVSLACAGGHLAVVELLL---------AHGADP 661
+ + L+ A++ N ATA N+ +T + AC GH VELLL + P
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSP 791
Query: 662 THRL-------------------------KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
H G T L AA H + LL + V S
Sbjct: 792 LHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS 851
Query: 697 VPTTDVSQLPPPSQDQSQVPRVPTHTLAMVVPPQEPDRTSQENS 740
V +T + L +++ T+T+ M+V + T Q+NS
Sbjct: 852 VDSTGKTPLMMAAENGQ------TNTVEMLVSSASAELTLQDNS 889
Score = 162 bits (409), Expect = 5e-39
Identities = 160/588 (27%), Positives = 258/588 (43%), Gaps = 64/588 (10%)
Query: 161 ADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNA 220
A K + P + +V CA EA L N + + + +L A G
Sbjct: 102 ARDKNWQTPLHIAAANKAVKCA--EALVPLL----SNVNVSDRAGRTALHHAAFSGHGEM 155
Query: 221 VRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAAS 280
V+ LL G ++N ++ + A G+ E+ ++L++ A V + K TPL AA+
Sbjct: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS-YTPLHAAA 214
Query: 281 SGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHT 340
S G + +VK LL D+N +A GNT L AC G +V L++ GA + NE G T
Sbjct: 215 SSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274
Query: 341 PLMEAASAGHVEVA-RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399
PL AA++ H + +L+ +GA +N S + K + L + G + ++++GA +
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVID 333
Query: 400 HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIE 459
+ +T L A GH + L+ SGA PL LAA G + L+
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
Query: 460 RGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSE 519
G +++ +D G T L AA G+ E + LLL GA+ N + ++ + L A +
Sbjct: 394 SGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-KKDKFGRSPLHYAAANCNYQ 452
Query: 520 VADFLIKAGADI----ELGCSTPLMEASQEGHLELVKYLLASGAN-----------VHAT 564
L+ +GA + E GC+ A+ + + ++YLL + AN VH +
Sbjct: 453 CLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYS 512
Query: 565 TATGD----------------------------------TALTYACENGHTDVADVLLQA 590
A G + L A +GH +VL+Q+
Sbjct: 513 AAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQS 572
Query: 591 GADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAV 650
DL+ + GRTPL AA GH+ V LI++GA++ T + A GH
Sbjct: 573 LLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSEC 632
Query: 651 VELLLAHGADPTHRLK----DGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
+ LL+ + A+P + + +G T L+ + GHT+ V LL+ NV
Sbjct: 633 LRLLIGN-AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANV 679
Score = 155 bits (391), Expect = 6e-37
Identities = 150/502 (29%), Positives = 218/502 (43%), Gaps = 23/502 (4%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L A S G ++ V+ LLD G +NE G + L +AC G + L+ A V +
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
Query: 269 NKGDITPL--MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
KG TPL AAS+ G L ++LL+ + ADVN +S G T L G + ++
Sbjct: 270 EKG-FTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQ 327
Query: 327 EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLD 386
GA I+ ++NG+TPL AA GH + L+ GA L LA G D
Sbjct: 328 SGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD-TAKRGIHGMFPLHLAALSGFSD 386
Query: 387 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAA 446
R LL +G D + D T L A G++E LLL++GA N SPL AA
Sbjct: 387 CCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Query: 447 CGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHE-EMVALLLAQGANINAQTEETQ 505
+ + L+ GA++ ++++ G TPL AA + + + LL AN + ++
Sbjct: 447 ANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGY 506
Query: 506 ETALTLACCG--------GFSEVADFLIKAGADIELGCS------TPLMEASQEGHLELV 551
A G D L++ L S +PL A+ GH + +
Sbjct: 507 NAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQAL 566
Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD-LEHESEGGRTPLMKAAR 610
+ L+ S ++ ++G T L A GH + DVL+ GA L + RTP+ AA
Sbjct: 567 EVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAAT 626
Query: 611 AGHLCTVQFLISKGANVNRATA--NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDG 668
GH ++ LI N N T + L+ GH V LL GA+ + K G
Sbjct: 627 NGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWG 686
Query: 669 STMLIEAAKGGHTNVVSYLLDY 690
T L A GH V LL +
Sbjct: 687 RTALHRGAVTGHEECVDALLQH 708
Score = 148 bits (373), Expect = 8e-35
Identities = 103/324 (31%), Positives = 177/324 (54%), Gaps = 8/324 (2%)
Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
A+ A GH E+V +L++ A++ +DKK +TPL AA++G + VV+ LLD G D+ +
Sbjct: 176 AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-E 234
Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI-IKILLN 1176
+TPL +AC G+ VV+ L+ GA +N +TPL AA+ + + +++L+
Sbjct: 235 PNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVG 294
Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
GA++N + SK G +PL + A++G + ++ G+ I+ + + N NT L +A G
Sbjct: 295 NGADVNMK--SKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE-DKNGNTPLHIAARYGH 351
Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
+++ L+ A+ R G+ PL AA G+++ R LL G D++ P T L
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP--DDFGRTCL 409
Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
AA G+ + LL++ GA + ++K G +PL A+ ++ + LV +GA V+ D
Sbjct: 410 HAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 1357 RKITPL-MSAFRKGHVKVVQYLVK 1379
R TPL +A K ++YL++
Sbjct: 470 RGCTPLHYAATSDTDGKCLEYLLR 493
Score = 147 bits (370), Expect = 2e-34
Identities = 112/352 (31%), Positives = 177/352 (50%), Gaps = 9/352 (2%)
Query: 342 LMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHK 401
L++A G + R L+ +N NE K + L A Y G +++ L+ +GA K
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNE-KRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
+ T L A E ++LL A VN ++++PL +AA V+ A L+
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
+N+ + G T L AA GH EMV LLL++GANINA ++ A+ A G EV
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-FDKKDRRAIHWAAYMGHIEVV 189
Query: 522 DFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
L+ GA++ + TPL A+ G + +VKYLL G +++ A G+T L AC N
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 579 GHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH--LCTVQFLISKGANVNRATANNDH 636
G V + L+ GA + ++E G TPL AA + H LC ++ L+ GA+VN + +
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC-LELLVGNGADVN-MKSKDGK 307
Query: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
T + + G + + ++ GA K+G+T L AA+ GH +++ L+
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Score = 146 bits (369), Expect = 2e-34
Identities = 126/423 (29%), Positives = 192/423 (45%), Gaps = 9/423 (2%)
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
D L+ A G D V+ L+ DVN Q T L A G +I+++L+ GA +
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
+ TPL A ++ E +VLL H A +N + ++ L +A + L
Sbjct: 68 NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW-QTPLHIAAANKAVKCAEAL 126
Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
+ ++ TAL A GH E+ +LLL GA +N + AA GH+
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI 186
Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
E+ LL+ GA + + + YTPL AA G +V LL G ++N + T L +
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN-EPNAYGNTPLHV 245
Query: 512 ACCGGFSEVADFLIKAGADI----ELGCSTPLMEASQEGHLEL-VKYLLASGANVHATTA 566
AC G V + LI GA + E G TPL A+ H L ++ L+ +GA+V+ +
Sbjct: 246 ACYNGQDVVVNELIDCGAIVNQKNEKG-FTPLHFAAASTHGALCLELLVGNGADVNMKSK 304
Query: 567 TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGAN 626
G T L +G + ++Q+GA ++ E + G TPL AAR GH + LI+ GA+
Sbjct: 305 DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGAD 364
Query: 627 VNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSY 686
+ + + LA G LL+ G D G T L AA GG+ ++
Sbjct: 365 TAKRGIHGMFP-LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNL 423
Query: 687 LLD 689
LL+
Sbjct: 424 LLN 426
Score = 142 bits (358), Expect = 4e-33
Identities = 131/447 (29%), Positives = 201/447 (44%), Gaps = 46/447 (10%)
Query: 264 VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKV 323
+ D N+ I+PL A+ G+ +++L+ D++ ++++G T L A G V+ V V
Sbjct: 542 LSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDV 601
Query: 324 LLNEGANI--EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK--ESALTLA 379
L+N+GA+I +D+ TP+ AA+ GH E R+L+ + N + ++ L L+
Sbjct: 602 LINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
GH D V LL GA+ + K TAL + GH E LL GA+ +
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 440 SPLTLAACGGHVELAALLIERGANLEE----VNDEGYTPLMEAAREGHEEMVALLLAQGA 495
+P+ L+A GH+ + L++ A+++ ++ GYT L A GHE V LLL Q
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ-- 778
Query: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLL 555
+ +TE + L A A+ LI LG S
Sbjct: 779 EVFQKTEGNAFSPLHCAVINDNEGAAEMLIDT-----LGASI------------------ 815
Query: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
V+AT + G T L A H + +LL A + G+TPLM AA G
Sbjct: 816 -----VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTN 870
Query: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGS-----T 670
TV+ L+S + N+ +T + LAC+ GH L+L D L + + T
Sbjct: 871 TVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD--RNLINATNAALQT 928
Query: 671 MLIEAAKGGHTNVVSYLLDYPNNVLSV 697
L AA+ G T VV LL +VL+V
Sbjct: 929 PLHVAARNGLTMVVQELLGKGASVLAV 955
Score = 141 bits (355), Expect = 9e-33
Identities = 109/353 (30%), Positives = 163/353 (46%), Gaps = 36/353 (10%)
Query: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
+L A G + V LI + + +D + TPL AA G ++E+L+ G + A+
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
+ TPL A + +E V +LL A+ R+ + TPL +AA+ V + L+
Sbjct: 71 DSKWL-TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
+ +N + G + L AA +GH VKLLL G++INA + +R A+ A + G
Sbjct: 130 LSNVN--VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR-AIHWAAYMGHI 186
Query: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD---- 1293
EVV LL+ A V + K TPL AAS G V + LLD G D+N P +
Sbjct: 187 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA 246
Query: 1294 ---------------------------TALTIAADKGHYKFC-ELLIHRGAHIDVRNKKG 1325
T L AA H C ELL+ GA +++++K G
Sbjct: 247 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDG 306
Query: 1326 NTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
TPL + + G F Q ++Q+GA +D D TPL A R GH ++ L+
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Score = 140 bits (352), Expect = 2e-32
Identities = 109/348 (31%), Positives = 165/348 (47%), Gaps = 42/348 (12%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L A G E++ +LI A++ +D K TPL A + V++LL D+ A
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNA 102
Query: 1117 Q--------------------------------SERTKDTPLSLACSGGRQEVVDLLLAR 1144
+ S+R T L A G E+V LLL+R
Sbjct: 103 RDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSR 162
Query: 1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVP 1204
GAN + D + AA G++ ++K+L++ GAE+ + K +PL AA +G +
Sbjct: 163 GANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK--DKKSYTPLHAAASSGMIS 220
Query: 1205 AVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEA 1264
VK LLD+G D+N + NT L +AC+ G+ VV+ L+D A V + + G TPL A
Sbjct: 221 VVKYLLDLGVDMN-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFA 279
Query: 1265 ASGGYAEVG-RVLLDKGADVNAPPVPSSRD--TALTIAADKGHYKFCELLIHRGAHIDVR 1321
A+ + + +L+ GADVN S+D T L + A G + + +I GA ID
Sbjct: 280 AASTHGALCLELLVGNGADVNM----KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCE 335
Query: 1322 NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
+K GNTPL +A+ GH ++ L+ +GAD + PL A G
Sbjct: 336 DKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Score = 134 bits (337), Expect = 1e-30
Identities = 133/477 (27%), Positives = 205/477 (42%), Gaps = 44/477 (9%)
Query: 142 TQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNA 201
++ L+ L+E +G LS +D +A P L AL+ +L + NS
Sbjct: 526 SETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQ-ALEVLVQSLLDLDVRNSSGR 584
Query: 202 GQVDTRSLAEACSDGDVNAVRKLLDEGRS--VNEHTEEGESLLCLACSAGYYELAQVLL- 258
+D A G V V L+++G S V ++ + + + A + G+ E ++L+
Sbjct: 585 TPLDL-----AAFKGHVECVDVLINQGASILVKDYILK-RTPIHAAATNGHSECLRLLIG 638
Query: 259 -AMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGF 317
A N D + TPLM + G+ D V LL A+V+++ G TAL G
Sbjct: 639 NAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH 698
Query: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH---SNEFKES 374
+ V LL GA + G TP+ +A+ GH+ V LL A ++ + ++ +
Sbjct: 699 EECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
Query: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS-GAQVNM 433
AL ACY GH V LLE Q+ + + + L A ++ + A +L+D+ GA +
Sbjct: 759 ALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVINDNEGAAEMLIDTLGASIVN 817
Query: 434 PADSF-ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
DS +PL AA HVE LL+ A + V+ G TPLM AA G V +L++
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVS 877
Query: 493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVK 552
+ + ++ TAL LAC G A +++ D L
Sbjct: 878 SASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNL------------------- 918
Query: 553 YLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAA 609
++AT A T L A NG T V LL GA + E G TP + A
Sbjct: 919 --------INATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
Score = 122 bits (305), Expect = 6e-27
Identities = 108/394 (27%), Positives = 173/394 (43%), Gaps = 59/394 (14%)
Query: 1059 LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS 1118
L LA GH + + VL+ ++ R+ G TPL LAA GHV V++L+++G I +
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 1119 ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILL 1175
K TP+ A + G E + LL+ + ++ D TPL L+ G+ + + LL
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673
Query: 1176 NAGAEINSRT-------------------------GSKL------GISPLMLAAMNGHVP 1204
N GA ++++ G+K G +P+ L+A GH+
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
Query: 1205 AVKLLLDMGSDINAQIETNRN---TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL 1261
+ LL + ++A T N TAL AC+ G V LLL+++ + +PL
Sbjct: 734 VLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEGNAFSPL 792
Query: 1262 MEAASGGYAEVGRVLLDK-GAD-VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHID 1319
A +L+D GA VNA S T L AA H + +LL+ A ++
Sbjct: 793 HCAVINDNEGAAEMLIDTLGASIVNA--TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850
Query: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQ-AGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
+ G TPL +A+ G + V++LV A A++ DN K T L A KGH
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH-------- 902
Query: 1379 KEVNQFPSDIECMRYIATITDKELLKKCHQCVET 1412
+ + + ITD+ L+ + ++T
Sbjct: 903 --------ETSALLILEKITDRNLINATNAALQT 928
Score = 119 bits (297), Expect = 5e-26
Identities = 110/371 (29%), Positives = 172/371 (46%), Gaps = 51/371 (13%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV-VEILLDKGGDI 1114
+T L +AC G + +V+ LI A + +++KGFTPL AA + H + +E+L+ G D+
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299
Query: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKIL 1174
+S+ K TPL + GR ++ GA + + + TPL +AA G+ +I L
Sbjct: 300 NMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTL 358
Query: 1175 LNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQ 1234
+ +GA+ R G+ PL LAA++G + LL G DI+ + R T L A
Sbjct: 359 ITSGADTAKR--GIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGR-TCLHAAAAG 415
Query: 1235 GRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN------APPV 1288
G E ++LLL+ A+ + K G +PL AA+ + L+ GA VN P+
Sbjct: 416 GNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPL 475
Query: 1289 ----------------------PSSRD----TALTIAADKGHYKFCELLIHRGAHIDV-- 1320
P RD A+ +A GH + C LI +DV
Sbjct: 476 HYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH-RLCLQLIASETPLDVLM 534
Query: 1321 -----------RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
N+ +PL LA+ GH +++LVQ+ D+D ++ TPL A KG
Sbjct: 535 ETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKG 594
Query: 1370 HVKVVQYLVKE 1380
HV+ V L+ +
Sbjct: 595 HVECVDVLINQ 605
Score = 117 bits (293), Expect = 1e-25
Identities = 101/329 (30%), Positives = 150/329 (45%), Gaps = 16/329 (4%)
Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
+VDI + N T L L+ GH + V L+ + A ++ +DK G T L A GH
Sbjct: 645 AVDIQ---DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEEC 701
Query: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLL----ARGANKEHRNVSDYTPL 1159
V+ LL G + R + TP+ L+ + G V+ LL + AN + YT L
Sbjct: 702 VDALLQHGAKCLLRDSRGR-TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTAL 760
Query: 1160 SLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD-MGSDINA 1218
A G+ +++LL E+ +T SPL A +N + A ++L+D +G+ I
Sbjct: 761 HWACYNGHETCVELLLE--QEVFQKTEGN-AFSPLHCAVINDNEGAAEMLIDTLGASIVN 817
Query: 1219 QIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
++ T L A F E + LLL A V TG TPLM AA G +L+
Sbjct: 818 ATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLV- 876
Query: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH---IDVRNKKGNTPLWLASNG 1335
A +S++TAL +A KGH L++ + I+ N TPL +A+
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
Query: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMS 1364
G VVQ L+ GA V A D TP ++
Sbjct: 937 GLTMVVQELLGKGASVLAVDENGYTPALA 965
Score = 103 bits (256), Expect = 3e-21
Identities = 80/260 (30%), Positives = 130/260 (50%), Gaps = 6/260 (2%)
Query: 1120 RTKDTP-LSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
+ +D P L A G + V L+ + + ++ TPL AA G II++L+ +G
Sbjct: 5 KLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSG 64
Query: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238
A +N++ L +PL A + AV++LL +D+NA+ + N T L +A +
Sbjct: 65 ARVNAKDSKWL--TPLHRAVASCSEEAVQVLLKHSADVNAR-DKNWQTPLHIAAANKAVK 121
Query: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTI 1298
L+ +NV + G T L AA G+ E+ ++LL +GA++NA R A+
Sbjct: 122 CAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRR--AIHW 179
Query: 1299 AADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRK 1358
AA GH + +LL+ GA + ++KK TPL A++ G VV+ L+ G D++ +
Sbjct: 180 AAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239
Query: 1359 ITPLMSAFRKGHVKVVQYLV 1378
TPL A G VV L+
Sbjct: 240 NTPLHVACYNGQDVVVNELI 259
Score = 94.7 bits (234), Expect = 1e-18
Identities = 88/321 (27%), Positives = 147/321 (45%), Gaps = 45/321 (14%)
Query: 215 DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
+G + V LL++G +V+ + G + L G+ E LL A R ++G T
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-T 721
Query: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSAT----GNTALTYACAGGFVDIVKVLL----- 325
P+ +++ G++ ++ LL A +++ AT G TAL +AC G V++LL
Sbjct: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVF 781
Query: 326 ------------------NEGAN-----------IEDHNENGHTPLMEAASAGHVEVARV 356
NEGA + + G TPL AA HVE ++
Sbjct: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
Query: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-AGADQEHKTDEMHTALMEACMD 415
LL H A +N+ + K + L +A G + V L+ A A+ + + +TAL AC
Sbjct: 842 LLSHNAQVNSVDSTGK-TPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 416 GHVEVARLLLDSGAQ---VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY 472
GH A L+L+ +N + ++PL +AA G + L+ +GA++ V++ GY
Sbjct: 901 GHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGY 960
Query: 473 TPLMEAA-REGHEEMVALLLA 492
TP + A + + +AL+LA
Sbjct: 961 TPALACAPNKDVADCLALILA 981
Score = 68.9 bits (167), Expect = 6e-11
Identities = 54/193 (27%), Positives = 87/193 (45%), Gaps = 7/193 (3%)
Query: 1016 QTTE--CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSV 1073
Q TE +P C+ N + M I T+S T L A H E + +
Sbjct: 782 QKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
Query: 1074 LIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGG 1133
L++ +A++ D G TPL++AA G VE+L+ + +K+T L LACS G
Sbjct: 842 LLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKG 901
Query: 1134 RQEVVDLLLARGANKEHRNVSD---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
+ L+L + ++ N ++ TPL +AA G +++ LL GA + + G
Sbjct: 902 HETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV--LAVDENG 959
Query: 1191 ISPLMLAAMNGHV 1203
+P + A N V
Sbjct: 960 YTPALACAPNKDV 972
Score = 43.5 bits (101), Expect = 0.003
Identities = 43/166 (25%), Positives = 73/166 (43%), Gaps = 1/166 (0%)
Query: 529 ADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLL 588
A ++L L++A G + V+ L+ +V+ T L A G ++ ++L+
Sbjct: 2 AFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLI 61
Query: 589 QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648
+GA + + TPL +A + VQ L+ A+VN A N T + +A A +
Sbjct: 62 LSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVN-ARDKNWQTPLHIAAANKAV 120
Query: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
E L+ ++ + G T L AA GH +V LL N+
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Score = 42.7 bits (99), Expect = 0.005
Identities = 30/107 (28%), Positives = 55/107 (51%), Gaps = 9/107 (8%)
Query: 1311 LIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGH 1370
LI + ++ ++ + TPL A+ G ++++LL+ +GA V+A D++ +TPL A
Sbjct: 27 LIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCS 86
Query: 1371 VKVVQYLVK---EVNQFPSDIECMRYIATITDKELLKKCHQCVETIV 1414
+ VQ L+K +VN + + +IA K +C E +V
Sbjct: 87 EEAVQVLLKHSADVNARDKNWQTPLHIAA------ANKAVKCAEALV 127
Score = 38.9 bits (89), Expect = 0.065
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 5/124 (4%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIAR--DAKIEHRDKKGF-TPLILAATAGHVGVVEILL 1108
+++ +TAL LAC+ GHE +++ + D + + TPL +AA G VV+ LL
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
Query: 1109 DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYV 1168
KG + A E TP +LAC+ + L L + S + L+ A Y
Sbjct: 947 GKGASVLAVDENGY-TP-ALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYT 1004
Query: 1169 NIIK 1172
N K
Sbjct: 1005 NTSK 1008
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 167 bits (423), Expect = 1e-40
Identities = 162/527 (30%), Positives = 232/527 (44%), Gaps = 59/527 (11%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
Query: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
Query: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
Query: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
+N H EFK +L A + L V+ L +
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
Query: 407 TALMEACMDGH---VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
+ ++ G T L AA GH + LLL+ G++ + + + T A G +E
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ----GFTAAQMG--NEAVQQ 637
Query: 524 LIKAGADIELG-CSTPLMEASQEGHLELVKYLLASGANVHATTATG--DTALTYACENGH 580
++ I L+EAS+ G LE VK L S NV+ G T L +A
Sbjct: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNR 696
Query: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
V + LL GAD+ + +GG PL A GH + L+ GA+VN A T +
Sbjct: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK-FTPLH 755
Query: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
A A G + +LLL HGADPT + +DG+T L + K G T++ L
Sbjct: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLL 801
Score = 166 bits (419), Expect = 4e-40
Identities = 176/565 (31%), Positives = 249/565 (44%), Gaps = 82/565 (14%)
Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGE--SLLCLACSAGYYELAQVLLAMHANV 264
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 184 RELLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 243 HARDD-GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
Query: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVLLDHGAGI 364
L GA+ N +G + L +EAA +G+ E LL +
Sbjct: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNV 360
Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY-------TP-- 474
LL GA VN +PL AA VE+ +LL+ GA+ VN G TP
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
L++AARE V LA IN + ++ ETAL A +
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
Query: 520 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
Query: 577 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 610
GH +LL G+D + ES RT L++A++
Sbjct: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
Query: 611 AGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
AG L TV+ L S NVN H T + A ++VVE LL HGAD + K G
Sbjct: 660 AGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
Query: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
L A GH V L+ + +V
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASV 743
Score = 150 bits (378), Expect = 2e-35
Identities = 173/616 (28%), Positives = 253/616 (41%), Gaps = 98/616 (15%)
Query: 149 LLEAAGIGKLSTADGKA---FADPEVLRRLTS---------SVSCALDEAAAALTRMKAE 196
LL+ + DGK+ ADP LT + +E AL
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
Query: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
N H + + L A V V+ LL G V+ + G L ACS G+YE+ ++
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-------- 308
LL H + + TPL A+S +++ LLL H AD + G +A
Sbjct: 421 LL-KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479
Query: 309 ----LTYACAGGFV-------DIVKV---------------------------------- 323
LTY G + D+ KV
Sbjct: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQ 539
Query: 324 ----LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
LL +GAN+ + N++ TPL AA H +V VL HGA +N + ++AL A
Sbjct: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRA 598
Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
GHL R LL G+D + + T A G+ V ++L +S + +
Sbjct: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSES---TPIRTSDVD 651
Query: 440 SPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
L A+ G +E + L + N ++ TPL AA +V LL GA+++
Sbjct: 652 YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
Query: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
A+ ++ L AC G EVA+ L++ GA + +L TPL EA+ +G E+ K LL
Sbjct: 712 AK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
Query: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
GA+ G+T L E G TD+ D+L G L+ AA+ G L
Sbjct: 771 KHGADPTKKNRDGNTPLDLVKE-GDTDIQDLL------------RGDAALLDAAKKGCLA 817
Query: 616 TVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
VQ L + N+N R T + T + LA +L V E LL HGAD + K G L
Sbjct: 818 RVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876
Query: 675 AAKGGHTNVVSYLLDY 690
AA GH ++ + L+ Y
Sbjct: 877 AASYGHVDIAALLIKY 892
Score = 138 bits (348), Expect = 6e-32
Identities = 133/453 (29%), Positives = 207/453 (45%), Gaps = 59/453 (13%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
Query: 325 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 358
L+ G++ + G T L+EA+ AG +E + L
Sbjct: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670
Query: 359 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 417
+N E + S L A + +V +LL GAD K L AC GH
Sbjct: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
Query: 418 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL
Sbjct: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787
Query: 477 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 515
+ +EG ++ LL A NIN + T+ T L LA
Sbjct: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
Query: 516 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
EVA++L++ GAD+ + G PL A+ GH+++ L+ V+AT T L
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
A + G T + +LL GAD +++ G+TPL
Sbjct: 908 HEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
Score = 124 bits (311), Expect = 1e-27
Identities = 114/386 (29%), Positives = 173/386 (44%), Gaps = 46/386 (11%)
Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS--- 1118
AC+ GH E+VS+L+ + A RD +TPL AA G + V +LL G D ++
Sbjct: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
Query: 1119 -----------------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
E KD L A SG ++++ LL N + TPL L
Sbjct: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375
Query: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
AA V I+++LL GA+++++ K G+ PL A GH +LLL G+ +NA ++
Sbjct: 376 AAGYNRVRIVQLLLQHGADVHAK--DKGGLVPLHNACSYGHYEVTELLLKHGACVNA-MD 432
Query: 1222 TNRNTALTLACFQGRAEVVSLLLDRKA-----NVEHRAKTGLTPLMEAASG-GYAEVGRV 1275
+ T L A + R EV SLLL A N ++ + P E Y G
Sbjct: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
Query: 1276 LLDKGADVNAPPV-------------PSSRDTALTIAADKGHYK---FCELLIHRGAHID 1319
LL + + V P S +TAL A H K ELL+ +GA+++
Sbjct: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552
Query: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
+NK TPL +A+ H DV+++L + GA ++A D T L A GH++ + L+
Sbjct: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL- 611
Query: 1380 EVNQFPSDIECMRYIATITDKELLKK 1405
PS I + A E +++
Sbjct: 612 SYGSDPSIISLQGFTAAQMGNEAVQQ 637
Score = 113 bits (283), Expect = 2e-24
Identities = 105/372 (28%), Positives = 165/372 (44%), Gaps = 23/372 (6%)
Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
L+ A G V V+ L+D K +PL A GR++VV+ LL GAN R
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
+ PL A S G+ ++ +LL GA+ N+R +PL AA+ G + +LL
Sbjct: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQ 303
Query: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
G+D N + T+ +AL LA D A + L+EAA G E
Sbjct: 304 HGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEE 349
Query: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
LL +VN + T L +AA + +LL+ GA + ++K G PL
Sbjct: 350 KLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
Query: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIEC- 1390
A + GH++V +LL++ GA V+A D + TPL A K V+V L+ P+ + C
Sbjct: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNCH 467
Query: 1391 ----MRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRK 1446
+ T +E L + + A++ A+ K ++ + +S E +
Sbjct: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
Query: 1447 QALAAKREKRKE 1458
A+A+ KRK+
Sbjct: 528 CAVASLHPKRKQ 539
Score = 113 bits (283), Expect = 2e-24
Identities = 108/378 (28%), Positives = 165/378 (43%), Gaps = 75/378 (19%)
Query: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD------------ 1109
AC+ GH E+ +L+ A + D FTPL AA+ V V +LL
Sbjct: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHG 468
Query: 1110 --------------------KGGDI-----EAQSERTKDT--------------PLSLAC 1130
KG + EA + K T +L C
Sbjct: 469 KSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC 528
Query: 1131 SGG-----RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
+ R++V +LLL +GAN +N TPL +AA + +++++L GA++N+
Sbjct: 529 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL- 587
Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
LG + L AA+ GH+ +LLL GSD + I TA + G V +L +
Sbjct: 588 -DTLGQTALHRAALAGHLQTCRLLLSYGSDPSI-ISLQGFTAAQM----GNEAVQQILSE 641
Query: 1246 ----RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
R ++V++R L+EA+ G E + L +VN + T L AA
Sbjct: 642 STPIRTSDVDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAG 693
Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
E L+H GA + ++K G PL A + GH++V +LLV+ GA V+ AD K TP
Sbjct: 694 YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
Query: 1362 LMSAFRKGHVKVVQYLVK 1379
L A KG ++ + L+K
Sbjct: 754 LHEAAAKGKYEICKLLLK 771
Score = 112 bits (280), Expect = 5e-24
Identities = 113/373 (30%), Positives = 171/373 (45%), Gaps = 41/373 (10%)
Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
PS E D L A +G E+L+++L + D + TPL LAA V
Sbjct: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVR 383
Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
+V++LL G D+ A+ ++ PL ACS G EV +LLL GA ++ +TPL A
Sbjct: 384 IVQLLLQHGADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
Query: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
AS V + +LL+ GA+ +N S + ++P L+ AA +
Sbjct: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLA---CFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
VK L + IN + + TAL A R +V LLL + ANV + K +TP
Sbjct: 503 AKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
L AA + +V VL GA +NA + + TAL AA GH + C LL+ G+ +
Sbjct: 562 LHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQA----GADVDAADNRKITPLMSAFRKGHVKVVQY 1376
+ +G T A+ G+ V Q+L ++ +DVD L+ A + G ++ V+
Sbjct: 620 ISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQ 668
Query: 1377 LVKEVNQFPSDIE 1389
L N D+E
Sbjct: 669 LCSSQNVNCRDLE 681
Score = 112 bits (280), Expect = 5e-24
Identities = 97/297 (32%), Positives = 136/297 (45%), Gaps = 23/297 (7%)
Query: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
E H T L A +V L+ A + +DK G PL A + GH V E+L+ G
Sbjct: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+ ++ K TPL A + G+ E+ LLL GA+ +N TPL L G I
Sbjct: 741 ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTL 1230
+ LL G + L+ AA G + V+ L +IN + RN T L L
Sbjct: 798 QDLLR-------------GDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHL 843
Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
A EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901
Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
T L AA KG + C LL+ GA ++N++G TPL LA+ D+ LL+ A
Sbjct: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
Score = 112 bits (279), Expect = 6e-24
Identities = 104/314 (33%), Positives = 153/314 (48%), Gaps = 25/314 (7%)
Query: 220 AVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG-DITPLMA 278
AV+++L E + T + + L A AG E + L + NV R +G TPL
Sbjct: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690
Query: 279 ASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENG 338
A+ + +V+ LL H ADV+++ G L AC+ G ++ ++L+ GA++ +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 339 HTPLMEAASAGHVEVARVLLDHGAGI-------NTHSNEFKE------------SALTLA 379
TPL EAA+ G E+ ++LL HGA NT + KE +AL A
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810
Query: 380 CYKGHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
KG L V+ L T + T L A ++EVA LL+ GA VN
Sbjct: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
PL AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+
Sbjct: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
Query: 499 AQTEETQETALTLA 512
+ +E Q T L LA
Sbjct: 931 MKNQEGQ-TPLDLA 943
Score = 109 bits (272), Expect = 4e-23
Identities = 113/354 (31%), Positives = 162/354 (45%), Gaps = 34/354 (9%)
Query: 1004 STRVPTGSNSSSQTTE----CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
S+ PT S+SSS ++ +PE+ S+ A P + A + + + L
Sbjct: 131 SSSSPTSSSSSSPSSPGSSLAESPEAAG--VSSTAPLGPGAAGPGTGVPAVSGALRE--L 186
Query: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
AC G V L+ A + +D G +PL AA G VVE LL G ++ A+
Sbjct: 187 LEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
Query: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
+ PL ACS G EVV LLL +GA+ R+ +YTPL AA G +++ +LL
Sbjct: 246 DDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 1178 GAEINSR-TGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
GA+ N R T K + L+ AA +G+ + LL ++N
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVNCH 363
Query: 1220 IETNR-NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
R +T L LA R +V LLL A+V + K GL PL A S G+ EV +LL
Sbjct: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
Query: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
GA VNA + + T L AA K + C LL+ GA + N G + + +A
Sbjct: 424 HGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
Score = 108 bits (270), Expect = 7e-23
Identities = 101/376 (26%), Positives = 162/376 (43%), Gaps = 54/376 (14%)
Query: 1052 ESNHD--TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
E N D T L +A H +++ VL AK+ D G T L AA AGH+ +LL
Sbjct: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
Query: 1110 KGGD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVDLLLA 1143
G D E+ RT D L + +G + V L +
Sbjct: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
Query: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHV 1203
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-- 1261
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
Query: 1262 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
++AA G A V ++ + ++N T L +AA
Sbjct: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
Query: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
+ + E L+ GA ++ ++K G PL A++ GH D+ LL++ V+A D TPL
Sbjct: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
Query: 1363 MSAFRKGHVKVVQYLV 1378
A +KG ++ L+
Sbjct: 908 HEAAQKGRTQLCALLL 923
Score = 105 bits (263), Expect = 4e-22
Identities = 105/383 (27%), Positives = 161/383 (42%), Gaps = 69/383 (18%)
Query: 1054 NHDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
+H+TAL A A H +++ +L+ + A + ++K TPL +AA H V+E+L
Sbjct: 521 SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
G + A + T L A G + LLL+ G++ ++ +T AA G +
Sbjct: 581 GAKMNAL-DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAV 635
Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
+IL + S +L + A+ G + VK L + +E +T L
Sbjct: 636 QQILSESTPIRTSDVDYRL-----LEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
A R VV LL A+V + K GL PL A S G+ EV +L+ GA VN +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADL-- 748
Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRN---------------------------- 1322
+ T L AA KG Y+ C+LL+ GA +N
Sbjct: 749 WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALL 808
Query: 1323 ---KKG-----------------------NTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
KKG +TPL LA+ + +V + L++ GADV+A D
Sbjct: 809 DAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDK 868
Query: 1357 RKITPLMSAFRKGHVKVVQYLVK 1379
+ PL +A GHV + L+K
Sbjct: 869 GGLIPLHNAASYGHVDIAALLIK 891
Score = 94.7 bits (234), Expect = 1e-18
Identities = 100/313 (31%), Positives = 131/313 (41%), Gaps = 23/313 (7%)
Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
S+ D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 648 SDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
G D+ A+ ++ PL ACS G EV +LL+ GA+ ++ +TPL AA+ G I
Sbjct: 707 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
K+LL GA+ + +G+ P L L D + Q + AL
Sbjct: 766 CKLLLKHGADPTKKN-------------RDGNTP---LDLVKEGDTDIQDLLRGDAALLD 809
Query: 1231 ACFQG-RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
A +G A V L N TPL AA EV LL+ GADVNA
Sbjct: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
Query: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
L AA GH LLI ++ +K TPL A+ G + LL+ GA
Sbjct: 870 GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Query: 1350 DVDAADNRKITPL 1362
D + TPL
Sbjct: 928 DPTMKNQEGQTPL 940
Score = 84.3 bits (207), Expect = 1e-15
Identities = 82/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)
Query: 1149 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKL 1208
E VS PL A+G G + + +G+ + L+ A NG V VK
Sbjct: 155 EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200
Query: 1209 LLDMGSDINAQIETNRNTA-LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1267
L+D +++NA+ R ++ L A GR +VV LL ANV R GL PL A S
Sbjct: 201 LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259
Query: 1268 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIHRGAHIDVRNK 1323
G+AEV +LL +GAD P++RD T L AA KG C +L+ GA ++RN
Sbjct: 260 GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313
Query: 1324 KGNTPLWLAS---------------------NGGHFDVVQLLVQAGADVDAADNRKITPL 1362
G + L LA +G ++ LL + A+D RK TPL
Sbjct: 314 DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373
Query: 1363 MSAFRKGHVKVVQYLVK 1379
A V++VQ L++
Sbjct: 374 HLAAGYNRVRIVQLLLQ 390
Score = 60.8 bits (146), Expect = 2e-08
Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 1/114 (0%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T+ + T L LA + E+ L+ A + +DK G PL AA+ GHV + +L+
Sbjct: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
+ A +++ TPL A GR ++ LLLA GA+ +N TPL LA +
Sbjct: 893 NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
Score = 42.4 bits (98), Expect = 0.006
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
Score = 36.6 bits (83), Expect = 0.32
Identities = 32/90 (35%), Positives = 41/90 (45%), Gaps = 2/90 (2%)
Query: 600 GGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHG 658
G L++A R G + V+ L+ ANVN + A + + A G VVE LL G
Sbjct: 181 GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
A+ R G L A GH VVS LL
Sbjct: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLL 269
Score = 32.7 bits (73), Expect = 4.7
Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 22/143 (15%)
Query: 1984 SSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMA---- 2039
S+ P P++ G AP T + T+ A+P D+P +
Sbjct: 25 SAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPV 84
Query: 2040 ----------NLCT-------PSSTANSCSSSASNTPGAPETH-PSSSPTPTSSNTQEEA 2081
+CT P+ + +S + A N G+ + PSSS +PTSS++ +
Sbjct: 85 DGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPS 144
Query: 2082 QPSSVSDLSPMSMPFASNSEPAP 2104
P S SP + +S + P
Sbjct: 145 SPGSSLAESPEAAGVSSTAPLGP 167
Score = 32.3 bits (72), Expect = 6.1
Identities = 35/164 (21%), Positives = 59/164 (35%), Gaps = 26/164 (15%)
Query: 1479 PKENSELPEDEDEEENDEDVEQEVPIEPPS-ATTTTTIGISATSATFTNVFGKKRANVVT 1537
P+ LPE + + + P++ S +TT+TI A + V A V
Sbjct: 59 PRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAP 118
Query: 1538 TPSTNRKNKKNKTKETPPTAHLILPEQ-HMSLAQQKADKNKINGEPRGGGAGG------- 1589
P+ + N + +P ++ P SLA+ + P G GA G
Sbjct: 119 NPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPA 178
Query: 1590 -------------NSDSDN----LDSTDCNSESSSGGKSQELNF 1616
N D +D+ + N++ +G KS L+F
Sbjct: 179 VSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHF 222
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 164 bits (416), Expect = 8e-40
Identities = 128/395 (32%), Positives = 196/395 (49%), Gaps = 54/395 (13%)
Query: 285 LDIVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPL 342
+ + +LL+L A++N ++ N A L G+ ++V +LL GAN++ +E+G TPL
Sbjct: 863 IKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTPL 922
Query: 343 MEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE-----AGAD 397
AA+AG++ + +L A ++ H ++ + AL A +GHL++V+FL++ AG
Sbjct: 923 GYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQ 981
Query: 398 QE--HKTDEMHTALMEACMDGHVEVARLLLD---------SGAQVNMPADSF--ESPLTL 444
Q K+ + AL+ A G+ E+ LLD AQ+N DS E+ LT
Sbjct: 982 QGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS-FDSLWGETALTA 1040
Query: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
AA G +E+ LL+E+GA + + N G PL R+GH ++V LLL GA++N ++
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
Query: 505 QETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHAT 564
+ TPLM A+ EGHL V +LLA GA++
Sbjct: 1101 R-------------------------------TPLMMAASEGHLGTVDFLLAQGASIALM 1129
Query: 565 TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
G TAL++AC GH V L+ GA +H + GRTPL AA G VQFL+ G
Sbjct: 1130 DKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHG 1189
Query: 625 ANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
A + + + A + +VV LL GA
Sbjct: 1190 AMIEHVDYSGMRP-LDRAVGCRNTSVVVTLLKKGA 1223
Score = 148 bits (373), Expect = 8e-35
Identities = 106/332 (31%), Positives = 167/332 (50%), Gaps = 24/332 (7%)
Query: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV---EVARLLLDSGAQVNMPADS 437
Y ++ + R L+ GA+ ++T+ ++ A + C+ H+ E+ LLL+ GA V+ ++S
Sbjct: 859 YTPNIKVSRLLILGGANINYRTEVLNNAPI-LCVQSHLGYTEMVALLLEFGANVDASSES 917
Query: 438 FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANI 497
+PL AA G++ + LL ++ A ++ ++ G L+ AA GH E+V L+ +
Sbjct: 918 GLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTM 977
Query: 498 NAQTE------ETQETALTLACCGGFSEVADFLI----KAGADIE---------LGCSTP 538
Q + + AL A G++E+ +L+ K ++E L T
Sbjct: 978 AGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETA 1037
Query: 539 LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHES 598
L A+ G LE+ + LL GA V G L GH + D+LL GAD+
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMAD 1097
Query: 599 EGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHG 658
+ GRTPLM AA GHL TV FL+++GA++ T +S AC GHL+VV L+ +G
Sbjct: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
Query: 659 ADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
A H K+G T L AA G VV +L+D+
Sbjct: 1157 AATDHADKNGRTPLDLAAFYGDAEVVQFLVDH 1188
Score = 144 bits (364), Expect = 8e-34
Identities = 116/370 (31%), Positives = 171/370 (46%), Gaps = 23/370 (6%)
Query: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
++ R L+ G ++N TE +LC+ GY E+ +LL ANV D ++ +T
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANV-DASSESGLT 920
Query: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL-------NE 327
PL A++ GYL IV LL A V+ G AL +A G +++VK L+ +
Sbjct: 921 PLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQ 980
Query: 328 GANIEDHNENGHTPLMEAASAGHVEVARVLLD---------HGAGINTHSNEFKESALTL 378
+ + L+ AAS G+ E+ LLD A IN+ + + E+ALT
Sbjct: 981 QQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTA 1040
Query: 379 ACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF 438
A +G L++ R LLE GA L GH ++ LLL GA VNM
Sbjct: 1041 AAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMADKQG 1100
Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
+PL +AA GH+ L+ +GA++ ++ EG T L A +GH +V L+ GA +
Sbjct: 1101 RTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATD 1160
Query: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLL 555
++ T L LA G +EV FL+ GA IE PL A + +V LL
Sbjct: 1161 -HADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL 1219
Query: 556 ASGANVHATT 565
GA + T
Sbjct: 1220 KKGAKIGPAT 1229
Score = 132 bits (333), Expect = 3e-30
Identities = 107/364 (29%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
G V LL+ G +V+ +E G + L A +AGY + +L A V+ G
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955
Query: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
L+AA+S GY +IV LL
Sbjct: 956 VHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE 1015
Query: 293 -----LHDADVNS-QSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAA 346
+ A +NS S G TALT A G +++ ++LL +GA + N G PL
Sbjct: 1016 KDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTV 1075
Query: 347 SAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
GH ++ +LL HGA +N + + + L +A +GHL V FLL GA E
Sbjct: 1076 RQGHWQIVDLLLTHGADVNMADKQGR-TPLMMAASEGHLGTVDFLLAQGASIALMDKEGL 1134
Query: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
TAL AC+ GH+ V R L+D+GA + + +PL LAA G E+ L++ GA +E
Sbjct: 1135 TALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEH 1194
Query: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT--EETQETALTLACCGGFSEVADFL 524
V+ G PL A + +V LL +GA I T T + + + E D
Sbjct: 1195 VDYSGMRPLDRAVGCRNTSVVVTLLKKGAKIGPATWAMATSKPDIMIILLSKLMEEGDMF 1254
Query: 525 IKAG 528
K G
Sbjct: 1255 YKKG 1258
Score = 122 bits (305), Expect = 6e-27
Identities = 103/322 (31%), Positives = 152/322 (47%), Gaps = 19/322 (5%)
Query: 1073 VLIARDAKIEHRDKKGFTPLILAATA--GHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
+LI A I +R + IL + G+ +V +LL+ G +++A SE TPL A
Sbjct: 868 LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGL-TPLGYAA 926
Query: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN-----AGAEINSRT 1185
+ G +V LL + A +H + + L AA G++ ++K L+ AG +
Sbjct: 927 AAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQCDWTMAGQQQGVFK 986
Query: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR---------NTALTLACFQGR 1236
S L+ AA G+ V LLD+ ++E + TALT A +G+
Sbjct: 987 KSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGK 1046
Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
EV LLL++ A V + G PL G+ ++ +LL GADVN T L
Sbjct: 1047 LEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNM--ADKQGRTPL 1104
Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
+AA +GH + L+ +GA I + +K+G T L A GH VV+ LV GA D AD
Sbjct: 1105 MMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADK 1164
Query: 1357 RKITPLMSAFRKGHVKVVQYLV 1378
TPL A G +VVQ+LV
Sbjct: 1165 NGRTPLDLAAFYGDAEVVQFLV 1186
Score = 120 bits (302), Expect = 1e-26
Identities = 94/296 (31%), Positives = 145/296 (48%), Gaps = 21/296 (7%)
Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
++ V +L+ G +I ++E + P+ S G E+V LLL GAN + + S TP
Sbjct: 862 NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESGLTP 921
Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINA 1218
L AA+ GY++I+ +L A+++ K G L+ AA+ GH+ VK L+ +
Sbjct: 922 LGYAAAAGYLSIVVLLCKKRAKVDHL--DKNGQCALVHAALRGHLEVVKFLIQCDWTMAG 979
Query: 1219 QIET------NRNTALTLACFQGRAEVVSLLLDRKANVEHRAKT----------GLTPLM 1262
Q + AL A G E+VS LLD E + G T L
Sbjct: 980 QQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLWGETALT 1039
Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
AA G EV R+LL++GA V P + T+ +GH++ +LL+ GA +++ +
Sbjct: 1040 AAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVR--QGHWQIVDLLLTHGADVNMAD 1097
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
K+G TPL +A++ GH V L+ GA + D +T L A KGH+ VV+ LV
Sbjct: 1098 KQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLV 1153
Score = 117 bits (294), Expect = 1e-25
Identities = 109/335 (32%), Positives = 157/335 (46%), Gaps = 29/335 (8%)
Query: 1066 GHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
G+ E+V++L+ A ++ + G TPL AA AG++ +V +L K ++ ++
Sbjct: 896 GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVD-HLDKNGQCA 954
Query: 1126 LSLACSGGRQEVVDLLLA---------RGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
L A G EVV L+ +G K+ + L AAS GY I+ LL+
Sbjct: 955 LVHAALRGHLEVVKFLIQCDWTMAGQQQGVFKKSHAIQQ--ALIAAASMGYTEIVSYLLD 1012
Query: 1177 AG---------AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTA 1227
A+INS S G + L AA G + +LLL+ G+ A + NR A
Sbjct: 1013 LPEKDEEEVERAQINS-FDSLWGETALTAAAGRGKLEVCRLLLEQGA---AVAQPNRRGA 1068
Query: 1228 LTL--ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1285
+ L QG ++V LLL A+V K G TPLM AAS G+ LL +GA +
Sbjct: 1069 VPLFSTVRQGHWQIVDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL 1128
Query: 1286 PPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLV 1345
+ TAL+ A KGH L+ GA D +K G TPL LA+ G +VVQ LV
Sbjct: 1129 --MDKEGLTALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLV 1186
Query: 1346 QAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
GA ++ D + PL A + VV L+K+
Sbjct: 1187 DHGAMIEHVDYSGMRPLDRAVGCRNTSVVVTLLKK 1221
Score = 115 bits (288), Expect = 5e-25
Identities = 140/526 (26%), Positives = 214/526 (40%), Gaps = 104/526 (19%)
Query: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
++DA +ES T L A A G+ +V +L + AK++H DK G L+ AA GH+ VV+
Sbjct: 910 NVDASSESGL-TPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVK 968
Query: 1106 I----------------------------------------LLDKGGDIEAQSERTK--- 1122
LLD E + ER +
Sbjct: 969 FLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINS 1028
Query: 1123 ------DTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
+T L+ A G+ EV LLL +GA N PL G+ I+ +LL
Sbjct: 1029 FDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLT 1088
Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1236
GA++N K G +PLM+AA GH+ V LL G+ I A ++ TAL+ AC +G
Sbjct: 1089 HGADVN--MADKQGRTPLMMAASEGHLGTVDFLLAQGASI-ALMDKEGLTALSWACLKGH 1145
Query: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1296
VV L+D A +H K G TPL AA G AEV + L+D GA + V S L
Sbjct: 1146 LSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIE--HVDYSGMRPL 1203
Query: 1297 TIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADN 1356
A + L+ +GA I W + ++ LL + + D
Sbjct: 1204 DRAVGCRNTSVVVTLLKKGAKI-------GPATWAMATSKPDIMIILLSKLMEEGD---- 1252
Query: 1357 RKITPLMSAFRKGHVKVV----QYLVKEVNQ--FPSDIECMRYIATITDKELLKKCHQCV 1410
++KG VK QY +K+ + F D++ R + LL +C
Sbjct: 1253 -------MFYKKGKVKEAAQRYQYALKKFPREGFGEDLKTFRELKV----SLLLNLSRCR 1301
Query: 1411 ETIVKAKDQQAAEANKNASILLKELDLE------KSREESRKQALAAK------------ 1452
K D AE ++ LK E +++ SR+ A A +
Sbjct: 1302 R---KMNDFGMAEEFATKALELKPKSYEAYYARARAKRSSRQFAAALEDLNEAIKLCPNN 1358
Query: 1453 REKRKEKRKKKKEEQKRKQEEDEENKPKENSELPEDEDEEENDEDV 1498
RE ++ + ++E ++ +Q + P+ +LPE+ + E ED+
Sbjct: 1359 REIQRLLLRVEEECRQMQQPQQPPPPPQPQQQLPEEAEPEPQHEDI 1404
Score = 72.8 bits (177), Expect = 4e-12
Identities = 67/243 (27%), Positives = 104/243 (42%), Gaps = 28/243 (11%)
Query: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETA-LTLACCGGFSEVADFLIKAGAD 530
YTP ++ +R LL+ GANIN +TE L + G++E+ L++ GA+
Sbjct: 859 YTPNIKVSR--------LLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGAN 910
Query: 531 IELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
++ TPL A+ G+L +V L A V G AL +A GH +V L
Sbjct: 911 VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970
Query: 588 LQAGADLEHESEGG-------RTPLMKAARAGHLCTVQFLIS----KGANVNRATANN-- 634
+Q + + +G + L+ AA G+ V +L+ V RA N+
Sbjct: 971 IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFD 1030
Query: 635 ---DHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYP 691
T ++ A G L V LLL GA + G+ L + GH +V LL +
Sbjct: 1031 SLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHG 1090
Query: 692 NNV 694
+V
Sbjct: 1091 ADV 1093
Score = 36.6 bits (83), Expect = 0.32
Identities = 34/120 (28%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDR 267
+L+ AC G ++ VR L+D G + + + G + L LA G E+ Q L+ A +E
Sbjct: 1136 ALSWACLKGHLSVVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHV 1195
Query: 268 GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE 327
G + PL A +V LL A + T+A A DI+ +LL++
Sbjct: 1196 DYSG-MRPLDRAVGCRNTSVVVTLLKKGAKIG--------PATWAMATSKPDIMIILLSK 1246
Score = 34.7 bits (78), Expect = 1.2
Identities = 46/179 (25%), Positives = 71/179 (39%), Gaps = 15/179 (8%)
Query: 1972 PATVISSVTSTCSSLPSVSSAPITS---GQAPTTFLPASTSQAQLSSQKMESFS-AVPPT 2027
P+ + + S SS P SA I+S G +S+S + Q +S S A+ PT
Sbjct: 1433 PSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPT 1492
Query: 2028 KEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHPSSSPTPTSSNTQEEAQPSSVS 2087
+ ++ +P +P+ S S G + +PS P+P Q A P + S
Sbjct: 1493 HQ--NSHYRPSPPHTSPAHQGGSYRFSPPPVGGQGKEYPSPPPSPLRRGPQYRASPPAES 1550
Query: 2088 -------DLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQP 2139
SP+ ++ P SP A Q +PQL V P+ R+QP
Sbjct: 1551 MSVYRSQSGSPVRYQQETSVSQLPGRPKSPLSKMA--QRPYQMPQLPVAVPQQGLRLQP 1607
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 162 bits (409), Expect = 5e-39
Identities = 158/568 (27%), Positives = 258/568 (45%), Gaps = 32/568 (5%)
Query: 156 GKLSTADGKAFAD-PEVLRRLTSSVSCALDEAAAALTRM-KAENSHNAGQVDTRSLAEAC 213
G+ G + D P+ S+ + +A L K + +DT L A
Sbjct: 12 GEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAA 71
Query: 214 SDGDVNAVRKLLDEG--RSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
++G + + K+ + ++E + G + L A E + LL+ AN R N
Sbjct: 72 AEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLR-NFN 130
Query: 272 DITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
+ PL A G +++K+LL H DVN + GNTA+ AC + +++LL +GA
Sbjct: 131 MMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAK 190
Query: 331 IEDHNENGHTPLMEAASAGHVEVARVLL----DHGAGINTH---SNEFKESALTLACYKG 383
N+ G P+ +AA +G E ++L +HG H N K + L LA G
Sbjct: 191 PCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNG 250
Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ----VNMPADSFE 439
L+M++ L+ GA + TA+ A G E+ +L++ S + VN E
Sbjct: 251 DLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHE 310
Query: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA 499
+ L A+ H ELA LI GA++ +++ EG +PL+ A +V LLL++GA ++
Sbjct: 311 TMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDI 370
Query: 500 QTEETQETA-LTLACCGGFSEVADFLIKAGADIEL-------GCSTPLMEASQEGHLELV 551
+ + LT+ G + ++ EL GC TPL A ++G V
Sbjct: 371 KDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGC-TPLHYACRQGGPGSV 429
Query: 552 KYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEG---GRTPLMKA 608
LL ++H+ + + L +A G + LLQ +D +EG G TPL A
Sbjct: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
Query: 609 ARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL-KD 667
A+ GH VQ L+ KGA + +N T + A GG+ ++++L T RL +D
Sbjct: 490 AKNGHDKVVQLLLKKGALF--LSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDED 547
Query: 668 GSTMLIEAAKGGHTNVVSYLLDYPNNVL 695
G+T L AA+ GH V+ LL + +++
Sbjct: 548 GNTALHFAAREGHAKAVALLLSHNADIV 575
Score = 94.0 bits (232), Expect = 2e-18
Identities = 101/413 (24%), Positives = 180/413 (43%), Gaps = 37/413 (8%)
Query: 1000 IAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
I +V + G+N + + + P + N + + ++D++ E N +TA+
Sbjct: 111 IESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAV 169
Query: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSE 1119
+AC + E + +L+ + AK +K G P+ AA +G +EI+L + G+ S
Sbjct: 170 IIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIIL-RFGEEHGYSR 228
Query: 1120 RT--------KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+ K TPL LA G E++ + L GA + T + AA+ G I+
Sbjct: 229 QLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIV 288
Query: 1172 KILLNAGAEINSRTGSKLGISPLML--AAMNGHVPAVKLLLDMGSDINAQIETNRNTALT 1229
K+++++ + + G ML A++ H L+ +G+DIN +I++ + L
Sbjct: 289 KLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADIN-KIDSEGRSPLI 347
Query: 1230 LACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA------------EVGRVLL 1277
LA +V+LLL + A V+ + G L Y ++ +++
Sbjct: 348 LATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVM 407
Query: 1278 DKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGH 1337
D+ D P L A +G L+ I ++K +PL A++ G
Sbjct: 408 DEDNDGCTP---------LHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGR 458
Query: 1338 FDVVQLLVQAGAD---VDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSD 1387
+ Q L+Q +D ++ D +TPL A + GH KVVQ L+K+ F SD
Sbjct: 459 INTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSD 511
Score = 92.8 bits (229), Expect = 4e-18
Identities = 96/313 (30%), Positives = 138/313 (44%), Gaps = 17/313 (5%)
Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
SVDI T+ H+T L A H EL LI+ A I D +G +PLILA + +
Sbjct: 298 SVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNI 357
Query: 1104 VEILLDKGGDIEAQS-------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
V +LL KG ++ + T P L R E + + + + N
Sbjct: 358 VNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL--KNLRPEFMQMQQIKELVMDEDN-DGC 414
Query: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
TPL A G + LL I+S++ K SPL AA G + + LL SD
Sbjct: 415 TPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKK--SPLHFAASYGRINTCQRLLQDISDT 472
Query: 1217 NAQIETNRN--TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
E + + T L LA G +VV LLL +K + G T L A+ GGY + +
Sbjct: 473 RLLNEGDLHGMTPLHLAAKNGHDKVVQLLL-KKGALFLSDHNGWTALHHASMGGYTQTMK 531
Query: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
V+LD + +TAL AA +GH K LL+ A I V NK+ + L LA +
Sbjct: 532 VILDTNLKC-TDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALH 589
Query: 1335 GGHFDVVQLLVQA 1347
+VV ++++
Sbjct: 590 NKRKEVVLTIIRS 602
Score = 90.9 bits (224), Expect = 1e-17
Identities = 84/322 (26%), Positives = 141/322 (43%), Gaps = 44/322 (13%)
Query: 1044 SVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGV 1103
S+++ + +T L A E V L++R A R+ PL +A + V
Sbjct: 87 SLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEV 146
Query: 1104 VEILLD-KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
+++LL+ + D+ + E +T + +AC+ E + +LL +GA N P+ A
Sbjct: 147 MKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQA 205
Query: 1163 ASGGYVNIIKILLNAGAE--------INSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
A G ++I+L G E IN K +PL LA NG + +K+ LD G+
Sbjct: 206 AFSGSKECMEIILRFGEEHGYSRQLHINFMNNGK--ATPLHLAVQNGDLEMIKMCLDNGA 263
Query: 1215 DINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274
I+ +E R TA+ A QG E+V L++ + +G ++ G
Sbjct: 264 QID-PVEKGRCTAIHFAATQGATEIVKLMIS--------SYSGSVDIVNTTDG------- 307
Query: 1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASN 1334
+T L A+ H++ + LI GA I+ + +G +PL LA+
Sbjct: 308 ----------------CHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATA 351
Query: 1335 GGHFDVVQLLVQAGADVDAADN 1356
+++V LL+ GA VD DN
Sbjct: 352 SASWNIVNLLLSKGAQVDIKDN 373
Score = 81.3 bits (199), Expect = 1e-14
Identities = 83/345 (24%), Positives = 151/345 (43%), Gaps = 47/345 (13%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +GD+ ++ LD G ++ + + + A + G E+ +++++ ++ D N
Sbjct: 246 AVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTT 305
Query: 272 D---ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
D T L AS + ++ L+ AD+N + G + L A A +IV +LL++G
Sbjct: 306 DGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKG 365
Query: 329 ANIE--------------------------------------DHNENGHTPLMEAASAGH 350
A ++ D + +G TPL A G
Sbjct: 366 AQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGG 425
Query: 351 VEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD-EMH--T 407
LL I++ S + K+S L A G ++ + LL+ +D + ++H T
Sbjct: 426 PGSVNNLLGFNVSIHSKSKD-KKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMT 484
Query: 408 ALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANL-EE 466
L A +GH +V +LLL GA + + + L A+ GG+ + ++++ +
Sbjct: 485 PLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTA-LHHASMGGYTQTMKVILDTNLKCTDR 543
Query: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTL 511
++++G T L AAREGH + VALLL+ A+I ++ L L
Sbjct: 544 LDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLAL 588
Score = 73.6 bits (179), Expect = 2e-12
Identities = 62/256 (24%), Positives = 113/256 (44%), Gaps = 33/256 (12%)
Query: 1126 LSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKILLNAGAEINS 1183
L A + G+ E+++ + + + + DY TPL A + +K LL+ GA N
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGS-DINAQIETNRNTALTLACFQGRAEVVSL 1242
R + + +PL +A + +K+LL+ + D+N + E N NTA+ +AC +E + +
Sbjct: 127 RNFNMM--APLHIAVQGMNNEVMKVLLEHRTIDVNLEGE-NGNTAVIIACTTNNSEALQI 183
Query: 1243 LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
LL + A K G P+ +AA G E ++L G +
Sbjct: 184 LLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHG------------------ 225
Query: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
R HI+ N TPL LA G +++++ + GA +D + + T +
Sbjct: 226 ---------YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAI 276
Query: 1363 MSAFRKGHVKVVQYLV 1378
A +G ++V+ ++
Sbjct: 277 HFAATQGATEIVKLMI 292
Score = 39.3 bits (90), Expect = 0.050
Identities = 40/187 (21%), Positives = 74/187 (39%), Gaps = 35/187 (18%)
Query: 1194 LMLAAMNGHVPAV-KLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEH 1252
L AA G + + K+ D ++ +++ NT L A + + E V LL R AN
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
R + PL A G EV +VLL+
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLE---------------------------------- 152
Query: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
HR +++ + GNT + +A + + +Q+L++ GA ++ P+ A G +
Sbjct: 153 HRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKE 212
Query: 1373 VVQYLVK 1379
++ +++
Sbjct: 213 CMEIILR 219
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 159 bits (403), Expect = 3e-38
Identities = 164/560 (29%), Positives = 242/560 (43%), Gaps = 80/560 (14%)
Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANV 264
R L EAC +GDV V++L+ VN G L +AG+ ++ + LL ANV
Sbjct: 26 RELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
+ R + G + PL A S G+ ++V LLL H AD N++ T L A G +D+ VL
Sbjct: 85 QAR-DDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVL 143
Query: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
L GA N +G T L+E+A +G+ E LL +
Sbjct: 144 LQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLT-PLNV 202
Query: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 203 NCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTEL 262
Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
L+ GA VN +PL AA VE+ +LL+ GA+ +N D TP
Sbjct: 263 LVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQL 322
Query: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
L++AARE + L+ +N + +T ETAL A + +
Sbjct: 323 KERLAYEFKGHSLLQAAREADVTRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQ 381
Query: 520 VADFLIKAGADIELGCS---TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
+ + L++ GA+I TPL AS++ H ++V+ ++ A V+A G T+L A
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 577 ENGHTDVADVLLQAGADLEHESEGGRT--------------------------PLMKAAR 610
GH +LL G D S G T L++AA+
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAK 501
Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
AG + TV+ L + + R T + A ++VVE LL HGAD + K G
Sbjct: 502 AGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLV 561
Query: 671 MLIEAAKGGHTNVVSYLLDY 690
L A GH V L+ +
Sbjct: 562 PLHNACSYGHYEVAELLVKH 581
Score = 148 bits (373), Expect = 8e-35
Identities = 142/495 (28%), Positives = 224/495 (45%), Gaps = 76/495 (15%)
Query: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGY---YELAQVLLAMHANV 264
SL +A + DV ++K L +H + E+ L A ++ Y ++ ++LL AN+
Sbjct: 334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANI 393
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
++ K +TPL AS + D+V++++ H+A VN+ G T+L A G + ++L
Sbjct: 394 NEK-TKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Query: 325 LNEGAN-----------IEDHNENGHTPLMEAASAGHVEVARVLLDHGAG---------- 363
L+ G + ++ NEN L E S G+ E R LL+
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
Query: 364 ----INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHV 418
+N E ++S L A + +V +LL+ GAD K L AC GH
Sbjct: 513 TVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHY 572
Query: 419 EVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLME 477
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL +
Sbjct: 573 EVAELLVKHGAVVNV-ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL-D 630
Query: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST 537
++G ++ LL A ++A + C +++ D + ST
Sbjct: 631 LVKDGDTDIQDLLRGDAALLDAAKK---------GCLARVKKLSSPDNVNCRDTQGRHST 681
Query: 538 PLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHE 597
PL A+ +LE+ +YLL GA+V+A G L A GH DVA +L++ A +
Sbjct: 682 PLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNAT 741
Query: 598 SEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAH 657
+ TPL +AA+ G + CA LLLAH
Sbjct: 742 DKWAFTPLHEAAQKGR--------------------------TQLCA--------LLLAH 767
Query: 658 GADPTHRLKDGSTML 672
GADPT + ++G T L
Sbjct: 768 GADPTLKNQEGQTPL 782
Score = 146 bits (369), Expect = 2e-34
Identities = 170/580 (29%), Positives = 241/580 (41%), Gaps = 90/580 (15%)
Query: 175 LTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEH 234
L S +E AL N H + + L A V V+ LL G V H
Sbjct: 181 LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADV--H 238
Query: 235 TEEGESLLCL--ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLL 292
++ L+ L ACS G+YE+ + LL H + + TPL A+S +++ LLL
Sbjct: 239 AKDKGDLVPLHNACSYGHYEVTE-LLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLL 297
Query: 293 LH-----------------------------------------DADVN------------ 299
+ +ADV
Sbjct: 298 SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVN 357
Query: 300 -SQSATGNTALTYACAGGFV---DIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVAR 355
T TAL A A + I ++LL +GANI + + TPL A+ H +V
Sbjct: 358 FKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVE 417
Query: 356 VLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD 415
V++ H A +N N +++L A Y GHL R LL G D + + TAL
Sbjct: 418 VVVKHEAKVNALDN-LGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM---- 472
Query: 416 GHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTP 474
G+ V +LL + + N AD L AA G VE + L + N ++ TP
Sbjct: 473 GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTP 529
Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI--- 531
L AA +V LL GA+++A+ ++ L AC G EVA+ L+K GA +
Sbjct: 530 LHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
+L TPL EA+ +G E+ K LL GA+ G+T L ++G TD+ D+L
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV-KDGDTDIQDLLR--- 644
Query: 592 ADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVN-RATANNDHTVVSLACAGGHLAV 650
G L+ AA+ G L V+ L S NVN R T T + LA +L V
Sbjct: 645 ---------GDAALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEV 694
Query: 651 VELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
E LL HGAD + K G L AA GH +V + L+ Y
Sbjct: 695 AEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
Score = 119 bits (297), Expect = 5e-26
Identities = 118/404 (29%), Positives = 166/404 (41%), Gaps = 80/404 (19%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
T T L A G +++V L+ A ++ RD G PL A + GH VV +LL
Sbjct: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL--------- 1161
G D A+ + TPL A G+ +V +LL GA RN T L L
Sbjct: 114 GADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVL 172
Query: 1162 ------------AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
A SG ++ +L ++ G K +PL LAA V V+LL
Sbjct: 173 TGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRK--STPLHLAAGYNRVKIVQLL 230
Query: 1210 LDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1269
L G+D++A+ + L AC G EV LL+ A V TPL EAAS
Sbjct: 231 LQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNR 289
Query: 1270 AEVGRVLLDKGAD-----------VNAPPVP----------------------------- 1289
EV +LL GAD ++ P P
Sbjct: 290 VEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKK 349
Query: 1290 ------------SSRDTALTIAADKGHYK---FCELLIHRGAHIDVRNKKGNTPLWLASN 1334
+ +TAL AA + K CELL+ +GA+I+ + K+ TPL +AS
Sbjct: 350 HLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASE 409
Query: 1335 GGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
H DVV+++V+ A V+A DN T L A GH++ + L+
Sbjct: 410 KAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453
Score = 113 bits (283), Expect = 2e-24
Identities = 105/364 (28%), Positives = 169/364 (46%), Gaps = 35/364 (9%)
Query: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
PS E D L A +G E+++++L + D + TPL LAA V
Sbjct: 166 PSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVK 225
Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
+V++LL G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL A
Sbjct: 226 IVQLLLQHGADVHAK-DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEA 284
Query: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
AS V + +LL+ GA+ +N S + ++P L+ AA V
Sbjct: 285 ASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADV 344
Query: 1204 PAVKLLLDMGSDINAQIETNRNTALTLAC---FQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
+K L + +N + TAL A + R ++ LLL + AN+ + K LTP
Sbjct: 345 TRIKKHLSL-EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTP 403
Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
L A+ + +V V++ A VNA + + T+L AA GH + C LL+ G ++
Sbjct: 404 LHVASEKAHNDVVEVVVKHEAKVNA--LDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL--V 1378
+ +G T L + + VQ L+Q G + ++ L+ A + G V+ V+ L V
Sbjct: 462 ISLQGFTALQMGNEN-----VQQLLQEG--ISLGNSEADRQLLEAAKAGDVETVKKLCTV 514
Query: 1379 KEVN 1382
+ VN
Sbjct: 515 QSVN 518
Score = 113 bits (282), Expect = 3e-24
Identities = 107/382 (28%), Positives = 161/382 (42%), Gaps = 69/382 (18%)
Query: 1055 HDTALTLACAGGH---EELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
H+TAL A A + +++ +L+ + A I + K+ TPL +A+ H VVE+++
Sbjct: 364 HETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE 423
Query: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
+ A + T L A G + LLL+ G + ++ +T L + +
Sbjct: 424 AKVNAL-DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----V 477
Query: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLA 1231
+ LL G + + + L+ AA G V VK L + S IE ++T L A
Sbjct: 478 QQLLQEGISLGNSEADR----QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533
Query: 1232 CFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSS 1291
R VV LL A+V + K GL PL A S G+ EV +L+ GA VN +
Sbjct: 534 AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADL--W 591
Query: 1292 RDTALTIAADKGHYKFCELLIHRGAHIDVRN----------------------------- 1322
+ T L AA KG Y+ C+LL+ GA +N
Sbjct: 592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLD 651
Query: 1323 --KKG-----------------------NTPLWLASNGGHFDVVQLLVQAGADVDAADNR 1357
KKG +TPL LA+ + +V + L+Q GADV+A D
Sbjct: 652 AAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKG 711
Query: 1358 KITPLMSAFRKGHVKVVQYLVK 1379
+ PL +A GHV V L+K
Sbjct: 712 GLIPLHNAASYGHVDVAALLIK 733
Score = 110 bits (275), Expect = 2e-23
Identities = 107/315 (33%), Positives = 142/315 (45%), Gaps = 27/315 (8%)
Query: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
S D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 490 SEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQH 548
Query: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
G D+ A+ ++ PL ACS G EV +LL+ GA ++ +TPL AA+ G I
Sbjct: 549 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
Query: 1171 IKILLNAGAEIN--SRTGSK----------------LGISPLMLAAMNGHVPAVKLLLDM 1212
K+LL GA+ +R G+ G + L+ AA G + VK L
Sbjct: 608 CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667
Query: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
+ + +T L LA EV LL A+V + K GL PL AAS G+ +V
Sbjct: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
Query: 1273 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
+L+ A VNA T L AA KG + C LL+ GA ++N++G TPL L
Sbjct: 728 AALLIKYNACVNA--TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV 785
Query: 1333 SNGGHFDVVQLLVQA 1347
S DV LL A
Sbjct: 786 SAD---DVSALLTAA 797
Score = 109 bits (272), Expect = 4e-23
Identities = 99/342 (28%), Positives = 152/342 (44%), Gaps = 23/342 (6%)
Query: 1122 KDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEI 1181
K TPL A GR++VV+ LL GAN + R+ PL A S G+ ++ +LL GA+
Sbjct: 58 KSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADP 117
Query: 1182 NSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVS 1241
N+R +PL AA+ G + +LL G++ + T+ TAL LA
Sbjct: 118 NAR--DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR-NTDGRTALDLA---------- 164
Query: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
D A + L+E+A G E LL +VN + T L +AA
Sbjct: 165 ---DPSAKAVLTGEYKKDELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAG 220
Query: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
K +LL+ GA + ++K PL A + GH++V +LLV+ GA V+A D + TP
Sbjct: 221 YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280
Query: 1362 LMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIA-----TITDKELLKKCHQCVETIVKA 1416
L A K V+V L+ P+ + C A T KE L + + A
Sbjct: 281 LHEAASKNRVEVCSLLL-SYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAA 339
Query: 1417 KDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKE 1458
++ K+ S+ + ++ E + A A+ KRK+
Sbjct: 340 READVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQ 381
Score = 108 bits (269), Expect = 9e-23
Identities = 104/389 (26%), Positives = 162/389 (41%), Gaps = 68/389 (17%)
Query: 1048 DAHTESNHDTA-LTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
D H + D L AC+ GH E+ +L+ A + D FTPL AA+ V V +
Sbjct: 236 DVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 295
Query: 1107 LLDKGGD----------------------------------------------------- 1113
LL G D
Sbjct: 296 LLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM 355
Query: 1114 IEAQSERTKDTPLSLACSGG---RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
+ + +T +T L A + R+++ +LLL +GAN + TPL +A+ + ++
Sbjct: 356 VNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDV 415
Query: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
+++++ A++N+ LG + L AA GH+ +LLL G D N I TAL +
Sbjct: 416 VEVVVKHEAKVNAL--DNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI-ISLQGFTALQM 472
Query: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
G V LL + + A L+EAA G E + L + VN +
Sbjct: 473 ----GNENVQQLLQEGISLGNSEADR---QLLEAAKAGDVETVKKLCTVQS-VNCRDIEG 524
Query: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGAD 1350
+ T L AA E L+ GA + ++K G PL A + GH++V +LLV+ GA
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 1351 VDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
V+ AD K TPL A KG ++ + L++
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQ 613
Score = 107 bits (268), Expect = 1e-22
Identities = 99/369 (26%), Positives = 155/369 (42%), Gaps = 52/369 (14%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD--- 1113
T L +A H ++V V++ +AK+ D G T L AA GH+ +LL G D
Sbjct: 402 TPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNI 461
Query: 1114 -----------------------IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH 1150
I + L A +G + V L + N
Sbjct: 462 ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRD 521
Query: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
TPL AA V++++ LL GA+++++ K G+ PL A GH +LL+
Sbjct: 522 IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK--DKGGLVPLHNACSYGHYEVAELLV 579
Query: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL--------- 1261
G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 580 KHGAVVNVA-DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD 638
Query: 1262 -----------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
++AA G A V + L +VN T L +AA + + E
Sbjct: 639 IQDLLRGDAALLDAAKKGCLARVKK--LSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAE 696
Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
L+ GA ++ ++K G PL A++ GH DV LL++ A V+A D TPL A +KG
Sbjct: 697 YLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKG 756
Query: 1370 HVKVVQYLV 1378
++ L+
Sbjct: 757 RTQLCALLL 765
Score = 107 bits (267), Expect = 1e-22
Identities = 118/414 (28%), Positives = 177/414 (42%), Gaps = 49/414 (11%)
Query: 312 ACAGGFVDIVKVLLN-EGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNE 370
AC G V+ VK L+ E N D TPL AA G +V LL +GA + ++
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR-DD 89
Query: 371 FKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQ 430
L AC GH ++V LL GAD + + +T L EA + G ++V +LL GA+
Sbjct: 90 GGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAE 149
Query: 431 VNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE-MVAL 489
+ + L LA L E DE L+E+AR G+EE M+AL
Sbjct: 150 PTIRNTDGRTALDLADPSAKAVLTG---------EYKKDE----LLESARSGNEEKMMAL 196
Query: 490 LLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEG 546
L N +A ++ + T L LA ++ L++ GAD+ + G PL A G
Sbjct: 197 LTPLNVNCHA-SDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYG 255
Query: 547 HLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD------------- 593
H E+ + L+ GA V+A T L A +V +LL GAD
Sbjct: 256 HYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAID 315
Query: 594 ----------LEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
L +E +G L++AAR + ++ +S VN T + A
Sbjct: 316 LAPTPQLKERLAYEFKGHS--LLQAAREADVTRIKKHLSLEM-VNFKHPQTHETALHCAA 372
Query: 644 AGGH---LAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNV 694
A + + ELLL GA+ + K+ T L A++ H +VV ++ + V
Sbjct: 373 ASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKV 426
Score = 106 bits (264), Expect = 3e-22
Identities = 100/293 (34%), Positives = 137/293 (46%), Gaps = 28/293 (9%)
Query: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV--LLAMHANV 264
R L EA GDV V+KL +SVN EG L +AGY ++ V LL A+V
Sbjct: 494 RQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K+L
Sbjct: 553 HAK-DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLL 611
Query: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVL-LDHGAG 363
L GA+ N +G+TPL ++AA G + ARV L
Sbjct: 612 LQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCL--ARVKKLSSPDN 669
Query: 364 INTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVAR 422
+N + + S L LA +L++ +LL+ GAD + L A GHV+VA
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729
Query: 423 LLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPL 475
LL+ A VN +PL AA G +L ALL+ GA+ N EG TPL
Sbjct: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782
Score = 84.3 bits (207), Expect = 1e-15
Identities = 72/211 (34%), Positives = 93/211 (44%), Gaps = 31/211 (14%)
Query: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHR 1253
L A NG V VK L+ + ++T L A GR +VV LL ANV+ R
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQAR 87
Query: 1254 AKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCE 1309
GL PL A S G+AEV +LL GAD P++RD T L AA KG C
Sbjct: 88 DDGGLIPLHNACSFGHAEVVNLLLRHGAD------PNARDNWNYTPLHEAAIKGKIDVCI 141
Query: 1310 LLIHRGAHIDVRNKKGNTPLWLAS---------------------NGGHFDVVQLLVQAG 1348
+L+ GA +RN G T L LA +G ++ LL
Sbjct: 142 VLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLN 201
Query: 1349 ADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
+ A+D RK TPL A VK+VQ L++
Sbjct: 202 VNCHASDGRKSTPLHLAAGYNRVKIVQLLLQ 232
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 158 bits (400), Expect = 6e-38
Identities = 130/382 (34%), Positives = 178/382 (46%), Gaps = 6/382 (1%)
Query: 249 GYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA 308
G E ++LLA +V+ + G TPL+ A+ D+ LLL H AD N G
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASG-YTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431
Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
L +A G ++LL+ GA ++ G TPL AA VAR+L+ A N H
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491
Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
E K + L +A Y GH+ +V+ L GA+ + + + T L A G V + LL SG
Sbjct: 492 AEGK-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSG 550
Query: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
A + S PL AA G + +L+ GA+LE +G+TPL AA +GH E++
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD---IELGCSTPLMEASQE 545
LL AN+ A T L LA G V L++ GAD E TPL A Q
Sbjct: 611 LLAESHANMGA-LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
V LL ANVHA G T A G+T + VL++AGA L+ + TPL
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPL 729
Query: 606 MKAARAGHLCTVQFLISKGANV 627
A R+ + FL K +V
Sbjct: 730 QLALRSRKQGIMSFLEGKEPSV 751
Score = 151 bits (382), Expect = 7e-36
Identities = 126/415 (30%), Positives = 186/415 (44%), Gaps = 33/415 (7%)
Query: 273 ITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIE 332
+TPL + G ++ V+LLL H+ DV+ Q+A+G T L A D+ +LL GA+
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 333 DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLL 392
+E+G PL AA G AR+LLDHGA ++ E + L LA ++ R L+
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLLV 481
Query: 393 EAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVE 452
AD E T L A GHV + +LL GA+++ + +PL LA G V
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
L++ GA + ++ GY PL AA G + +LL GA++ T +
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW------- 594
Query: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
TPL A+ +GHLE++ L S AN+ A A T L
Sbjct: 595 ------------------------TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPL 630
Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
A +G V LLQ GAD + G TPL A + +V L+ ANV+ A
Sbjct: 631 HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH-ARN 689
Query: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
T LA G+ A++++L+ GA + T L A + ++S+L
Sbjct: 690 KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 145 bits (366), Expect = 5e-34
Identities = 117/365 (32%), Positives = 171/365 (46%), Gaps = 38/365 (10%)
Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
VD+D T S + T L +A +L ++L+A A D+ G+ PL AA G G
Sbjct: 386 VDVDCQTASGY-TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
+LLD G ++AQ ER TPL LA + V LL++R A+ TPL +AA
Sbjct: 445 RLLLDHGACVDAQ-EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAY 503
Query: 1165 GGYVNIIKILLNAGAEI-----NSRTGSKL--------------------------GISP 1193
G+V+++K+L + GAE+ N RT L G P
Sbjct: 504 FGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGP 563
Query: 1194 LMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEH 1252
L AA G K+LL G+ + ++ T++ T L LA ++G E++ LL + AN+
Sbjct: 564 LHTAAARGKYLICKMLLRYGASL--ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
Query: 1253 RAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLI 1312
TPL AA G V LL GAD NA S T L +A + + L+
Sbjct: 622 LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA--AEQSGWTPLHLAVQRSTFLSVINLL 679
Query: 1313 HRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVK 1372
A++ RNK G TP LA+ G+ ++++LV+AGA +D D TPL A R
Sbjct: 680 EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQG 739
Query: 1373 VVQYL 1377
++ +L
Sbjct: 740 IMSFL 744
Score = 134 bits (336), Expect = 1e-30
Identities = 106/330 (32%), Positives = 157/330 (47%), Gaps = 7/330 (2%)
Query: 1054 NHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGD 1113
N T L A G E V +L+A + ++ + G+TPL++AA + +LL G D
Sbjct: 361 NKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 1114 IEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKI 1173
E PL A G LLL GA + + +TPL LAA + N+ ++
Sbjct: 421 ANRVDE-DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 1174 LLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACF 1233
L++ A+ N G +PL +AA GHV VKLL G++++AQ + N T L LA
Sbjct: 480 LVSRQADPNLHEAE--GKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-QRNLRTPLHLAVE 536
Query: 1234 QGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD 1293
+G+ + LL A + ++G PL AA+ G + ++LL GA + P
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP--THQGW 594
Query: 1294 TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
T L +AA KGH + LL A++ TPL LA+ G VV L+Q GAD +A
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 1354 ADNRKITPL-MSAFRKGHVKVVQYLVKEVN 1382
A+ TPL ++ R + V+ L N
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHAN 684
Score = 127 bits (318), Expect = 2e-28
Identities = 115/367 (31%), Positives = 168/367 (45%), Gaps = 9/367 (2%)
Query: 335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN----EFKESALTLACYKGHLDMVRF 390
NE+ LM++ S +++ A L D + E K + L +G ++ VR
Sbjct: 321 NEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRL 380
Query: 391 LLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
LL D + +T +T L+ A D ++ LLL GA N + +PL AA G
Sbjct: 381 LLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGD 440
Query: 451 VELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALT 510
A LL++ GA ++ EG+TPL AA+ E + LL+++ A+ N E +T L
Sbjct: 441 DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH-EAEGKTPLH 499
Query: 511 LACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLLASGANVHATTAT 567
+A G + L GA+++ TPL A + G + +++LL SGA A +
Sbjct: 500 VAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQS 559
Query: 568 GDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627
G L A G + +LL+ GA LE + G TPL AA GHL + L AN+
Sbjct: 560 GYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANM 619
Query: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
A N T + LA G AVV LL GADP + G T L A + V L
Sbjct: 620 GALGAVN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINL 678
Query: 688 LDYPNNV 694
L++ NV
Sbjct: 679 LEHHANV 685
Score = 117 bits (293), Expect = 1e-25
Identities = 89/289 (30%), Positives = 142/289 (49%), Gaps = 2/289 (0%)
Query: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
A +GD R LLD G V+ EG + L LA + +A++L++ A+ +G
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
Query: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
TPL A+ G++ +VKLL A++++Q T L A G V ++ LL GA
Sbjct: 495 K-TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
+ +++G+ PL AA+ G + ++LL +GA + +++ + L LA YKGHL+++ L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQ-GWTPLHLAAYKGHLEIIHLL 612
Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
E+ A+ T L A G V LL GA N S +PL LA
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
Query: 452 ELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
L+E AN+ N G+TP AA +G+ ++ +L+ GA ++ Q
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQ 721
Score = 75.5 bits (184), Expect = 6e-13
Identities = 55/161 (34%), Positives = 78/161 (48%), Gaps = 2/161 (1%)
Query: 1220 IETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1279
I N+ T L QG E V LLL + +V+ + +G TPL+ AA ++ +LL
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 1280 GADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD 1339
GAD N V L AA G LL+ GA +D + ++G TPL LA+ +
Sbjct: 418 GADANR--VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 1340 VVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
V +LLV AD + + TPL A GHV +V+ L +
Sbjct: 476 VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516
Score = 46.2 bits (108), Expect = 4e-04
Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 1/134 (0%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L LA G E +VS L+ A ++ G+TPL LA V LL+ ++ A
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
++ + TP LA G ++ +L+ GA + ++ TPL LA I+ L
Sbjct: 688 RN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 1177 AGAEINSRTGSKLG 1190
+ + GSK G
Sbjct: 747 KEPSVATLGGSKPG 760
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 158 bits (400), Expect = 6e-38
Identities = 142/445 (31%), Positives = 215/445 (48%), Gaps = 26/445 (5%)
Query: 126 LSSTAEGADLRTVDPETQARL--EALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCAL 183
LS G PE +R E+ L ++G GK G + D R + S+S
Sbjct: 336 LSQLDSGVSQAVEGPEELSRSSSESKLPSSGSGK--RLSGVSSVDSAFSSRGSLSLSFER 393
Query: 184 DEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLC 243
+ + + L V + L +A GD + + K+L + + V+ + G SLL
Sbjct: 394 EPSTSDL---------GTTDVQKKKLVDAIVSGDTSKLMKIL-QPQDVDLALDSGASLLH 443
Query: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
LA AG E A+ LL +AN +G TPL A +V+LLL VN++
Sbjct: 444 LAVEAGQEECAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVNAKDE 502
Query: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG 363
TAL +A G ++LL + A++ + + G TP+ A G + R+LL G
Sbjct: 503 DQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVD 562
Query: 364 INTHSNEFKESALTL--ACYKGHLDMVRFLL-EAGADQEHKTDEMHTALMEACMDGHVEV 420
++ K++ L L A ++GHL +V+ L + G +T + T L A GH V
Sbjct: 563 VSLQG---KDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
Query: 421 ARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAR 480
AR+L+D + VN+ + ++PL +AA GH A LL+ RGA E + +GYT L AAR
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAAR 679
Query: 481 EGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA-DI--ELGCST 537
GH V LL+ + A++ A+ Q TAL LA G SEV + L+ A D+ E G S
Sbjct: 680 NGHLATVKLLVEEKADVLARGPLNQ-TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA 738
Query: 538 PLMEASQEGHLELVKYLLASGANVH 562
L A+Q H + V+ LL GA+++
Sbjct: 739 -LHLAAQGRHAQTVETLLRHGAHIN 762
Score = 139 bits (349), Expect = 5e-32
Identities = 118/370 (31%), Positives = 176/370 (47%), Gaps = 10/370 (2%)
Query: 1011 SNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEEL 1070
S S TT+ + S S+ M + P D+D +S + L LA G EE
Sbjct: 396 STSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSGA-SLLHLAVEAGQEEC 453
Query: 1071 VSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLAC 1130
L+ +A +++G TPL +A GVVE+LL + + A+ E + T L A
Sbjct: 454 AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDE-DQWTALHFAA 512
Query: 1131 SGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLG 1190
G + LLL + A+ + TP+ +A G NI++ILL G +++ + K
Sbjct: 513 QNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQ--GKDA 570
Query: 1191 ISPLMLAAMNGHVPAVKLLLDM-GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKAN 1249
PL AA GH+P VKLL G +NAQ R T L LA +G V +L+D ++
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSD 629
Query: 1250 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1309
V + TPL AA G+ R+LL +GA A + S TAL +AA GH +
Sbjct: 630 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA--MTSDGYTALHLAARNGHLATVK 687
Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
LL+ A + R T L LA+ GH +VV+ LV A +D D + ++ L A +
Sbjct: 688 LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGR 746
Query: 1370 HVKVVQYLVK 1379
H + V+ L++
Sbjct: 747 HAQTVETLLR 756
Score = 127 bits (319), Expect = 1e-28
Identities = 109/329 (33%), Positives = 155/329 (47%), Gaps = 10/329 (3%)
Query: 336 ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAG 395
++G + L A AG E A+ LL + A N SN + L +A + +V LL
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNL-SNRRGSTPLHMAVERRVRGVVELLLARK 494
Query: 396 ADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
K ++ TAL A +G RLLL+ A VN +P+ +A G +
Sbjct: 495 ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVR 554
Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ-GANINAQTEETQETALTLACC 514
+L+ RG ++ + + PL AA +GH +V LL Q G ++NAQT + + T L LA
Sbjct: 555 ILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGR-TPLHLAAQ 613
Query: 515 GGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
G VA LI +D+ + CS TPL A++ GH + LL GA A T+ G T
Sbjct: 614 RGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672
Query: 571 ALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
AL A NGH +L++ AD+ +T L AA GH V+ L+S A+V
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVS--ADVIDL 730
Query: 631 TANNDHTVVSLACAGGHLAVVELLLAHGA 659
+ + LA G H VE LL HGA
Sbjct: 731 FDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 122 bits (305), Expect = 6e-27
Identities = 92/297 (30%), Positives = 147/297 (49%), Gaps = 8/297 (2%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L +A +V +L+AR + +D+ +T L AA G +LL+K +
Sbjct: 473 TPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNE 532
Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
+ TP+ +AC G++ +V +LL RG + + + PL AA G++ I+K+L
Sbjct: 533 VDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAK 591
Query: 1177 A-GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
G +N++T G +PL LAA GH ++L+D+ SD+N T L +A G
Sbjct: 592 QPGVSVNAQTLD--GRTPLHLAAQRGHYRVARILIDLCSDVNV-CSLLAQTPLHVAAETG 648
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTA 1295
LLL R A E G T L AA G+ ++L+++ ADV A TA
Sbjct: 649 HTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARG--PLNQTA 706
Query: 1296 LTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVD 1352
L +AA GH + E L+ ID+ +++G + L LA+ G H V+ L++ GA ++
Sbjct: 707 LHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 112 bits (279), Expect = 6e-24
Identities = 81/278 (29%), Positives = 134/278 (48%), Gaps = 17/278 (6%)
Query: 1104 VEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA 1163
V++ LD G + L LA G++E LL AN N TPL +A
Sbjct: 431 VDLALDSGASL-----------LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
Query: 1164 SGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETN 1223
++++LL +N++ + + L AA NG + +LLL+ + +N +++
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQW--TALHFAAQNGDESSTRLLLEKNASVN-EVDFE 536
Query: 1224 RNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK-GAD 1282
T + +AC G+ +V +LL R +V + K PL AA G+ + ++L + G
Sbjct: 537 GRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS 596
Query: 1283 VNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQ 1342
VNA + T L +AA +GHY+ +LI + ++V + TPL +A+ GH +
Sbjct: 597 VNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTAR 654
Query: 1343 LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
LL+ GA +A + T L A R GH+ V+ LV+E
Sbjct: 655 LLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEE 692
Score = 110 bits (276), Expect = 1e-23
Identities = 125/442 (28%), Positives = 188/442 (42%), Gaps = 19/442 (4%)
Query: 36 GVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFK--LAAAVLRTGGGGGAS 93
GV + + S + SSG G SG D+A + L+ + R
Sbjct: 342 GVSQAVEGPEELSRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLG 401
Query: 94 GSDEDEVSEVESFIL-DQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEA 152
+D + V++ + D L + ++ L S A L + + LL
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 153 AGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEA 212
A LS G V RR+ V L A K E+ A L A
Sbjct: 462 AN-PNLSNRRGSTPLHMAVERRVRGVVELLL--ARKISVNAKDEDQWTA-------LHFA 511
Query: 213 CSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGD 272
+GD ++ R LL++ SVNE EG + + +AC G + ++LL +V +G K
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQG-KDA 570
Query: 273 ITPLMAASSGGYLDIVKLLLLHDA-DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
PL A+ G+L IVKLL VN+Q+ G T L A G + ++L++ +++
Sbjct: 571 WLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDV 630
Query: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFL 391
+ TPL AA GH AR+LL GAG +++ +AL LA GHL V+ L
Sbjct: 631 NVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSD-GYTALHLAARNGHLATVKLL 689
Query: 392 LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 451
+E AD + TAL A GH EV L+ S +++ + S L LAA G H
Sbjct: 690 VEEKADVLARGPLNQTALHLAAAHGHSEVVEELV-SADVIDLFDEQGLSALHLAAQGRHA 748
Query: 452 ELAALLIERGA--NLEEVNDEG 471
+ L+ GA NL+ + +G
Sbjct: 749 QTVETLLRHGAHINLQSLKFQG 770
Score = 107 bits (267), Expect = 1e-22
Identities = 93/299 (31%), Positives = 133/299 (44%), Gaps = 7/299 (2%)
Query: 402 TDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERG 461
TD L++A + G +L V++ DS S L LA G E A L+
Sbjct: 403 TDVQKKKLVDAIVSGDTSKLMKILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 462 ANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVA 521
AN N G TPL A +V LLLA+ ++NA+ E+ Q TAL A G
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED-QWTALHFAAQNGDESST 520
Query: 522 DFLIKAGA---DIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
L++ A +++ TP+ A Q G +V+ LL G +V L YA
Sbjct: 521 RLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
Query: 579 GHTDVADVLL-QAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHT 637
GH + +L Q G + ++ GRTPL AA+ GH + LI ++VN + T
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
Query: 638 VVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLS 696
+ +A GH + LLL GA DG T L AA+ GH V L++ +VL+
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
Score = 69.3 bits (168), Expect = 5e-11
Identities = 57/185 (30%), Positives = 78/185 (42%), Gaps = 32/185 (17%)
Query: 1066 GHEELVSVLIARDA-KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDT 1124
GH +V +L + + + G TPL LAA GH V IL+D D+ S + T
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQ-T 639
Query: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
PL +A G LLL RGA KE YT L LAA G++ +K+L+ A++ +R
Sbjct: 640 PLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLAR 699
Query: 1185 TG------------------------------SKLGISPLMLAAMNGHVPAVKLLLDMGS 1214
+ G+S L LAA H V+ LL G+
Sbjct: 700 GPLNQTALHLAAAHGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Query: 1215 DINAQ 1219
IN Q
Sbjct: 760 HINLQ 764
Score = 65.9 bits (159), Expect = 5e-10
Identities = 58/203 (28%), Positives = 87/203 (42%), Gaps = 3/203 (1%)
Query: 501 TEETQETALTLACCGG-FSEVADFLIKAGADIELGCSTPLMEASQE-GHLELVKYLLASG 558
T + Q+ L A G S++ L D+ L L+ + E G E K+LL +
Sbjct: 402 TTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQ 618
AN + + G T L A E V ++LL + + E T L AA+ G + +
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTR 521
Query: 619 FLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
L+ K A+VN T + +AC G +V +LL G D + + KD L AA
Sbjct: 522 LLLEKNASVNEVDFEG-RTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQ 580
Query: 679 GHTNVVSYLLDYPNNVLSVPTTD 701
GH +V L P ++ T D
Sbjct: 581 GHLPIVKLLAKQPGVSVNAQTLD 603
Score = 61.2 bits (147), Expect = 1e-08
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 12/153 (7%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
T L +A GH +L+ R A E G+T L LAA GH+ V++L+++ D+ A
Sbjct: 639 TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLA 698
Query: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
+ T L LA + G EVV+ L++ + + + L LAA G + ++ LL
Sbjct: 699 RGP-LNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
Query: 1177 AGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209
GA IN ++ L GH PA LL
Sbjct: 757 HGAHINLQS----------LKFQGGHGPAATLL 779
>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 2 [Homo sapiens]
Length = 1390
Score = 149 bits (375), Expect = 4e-35
Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)
Query: 287 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 907 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 966
Query: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 967 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1025
Query: 400 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 1026 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1085
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1086 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1138
Query: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 1139 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1174
Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 1175 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1232
Query: 633 NNDHT---VVSLACAGGHLAVVELLLAHGA 659
DH+ + A + +VV LL GA
Sbjct: 1233 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 139 bits (349), Expect = 5e-32
Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)
Query: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
Y ++ + R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 901 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 960
Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL
Sbjct: 961 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1020
Query: 493 --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
Q + + + ALT A G S V L+ + E+ + T L A
Sbjct: 1021 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1078
Query: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
+ G LE+ + LL GA V T G L A GH + +LL+ G D+ + GR
Sbjct: 1079 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1138
Query: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
TPLM AA GHL TV+FL+SKGA ++ + + +S AC GH AVV+ L+ GA
Sbjct: 1139 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1197
Query: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
K+G T L AA G V YL++
Sbjct: 1198 QTDKNGRTPLDLAAFYGDAETVLYLVE 1224
Score = 131 bits (330), Expect = 7e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 962
Query: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 963 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1022
Query: 331 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 1023 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1082
Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 1083 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1142
Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 1143 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1201
Query: 504 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 1202 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1261
Query: 561 VHATTATGDTALTYACENGHTDVADVLLQ 589
+ G+ A +A D+ +LLQ
Sbjct: 1262 L------GNAA--WAMATSKPDILIILLQ 1282
Score = 129 bits (323), Expect = 5e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 938 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 997
Query: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
L AA+S G+ +V+ LL
Sbjct: 998 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1057
Query: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 1058 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1117
Query: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 1118 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1176
Query: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 1177 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1236
Query: 472 YTPLMEAAREGHEEMVALLLAQGANI 497
PL A + +V LL +GA +
Sbjct: 1237 MRPLDRAIGCRNTSVVVALLRKGAKL 1262
Score = 120 bits (300), Expect = 2e-26
Identities = 108/345 (31%), Positives = 157/345 (45%), Gaps = 57/345 (16%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD- 1109
T N TAL A A GH +LV +L + +++H DKKG L+ +A GH +++ LL
Sbjct: 956 TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1015
Query: 1110 -------KGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSDY--- 1156
+ G + + L+ A S G VV LL G KEH N +D
Sbjct: 1016 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1071
Query: 1157 -TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
T L+ AA G + + ++LL GA + SRT + G+ PL AA
Sbjct: 1072 ETALTAAAGRGKLEVCELLLGHGAAV-SRTNRR-GVPPLFCAAR---------------- 1113
Query: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
QG ++V LLL+R +V K G TPLM AA G+
Sbjct: 1114 ------------------QGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVEF 1155
Query: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
LL KGA +++ + +AL+ A KGH + L+ GA ID +K G TPL LA+
Sbjct: 1156 LLSKGAALSS--LDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFY 1213
Query: 1336 GHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
G + V LV+ GA ++ D+ + PL A + VV L+++
Sbjct: 1214 GDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRK 1258
Score = 117 bits (293), Expect = 1e-25
Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)
Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
L + + GH VV +LL+ G ++ SE T L A + G ++V LL +G +H
Sbjct: 931 LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 989
Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
+ L +A G+ +I++ LL L S L AA GH V
Sbjct: 990 DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1049
Query: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
+ LL M + ++ TALT A +G+ EV LLL A V + G+ PL
Sbjct: 1050 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1109
Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
AA G+ ++ R+LL++G DVN T L +AA +GH E L+ +GA + +
Sbjct: 1110 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1167
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
K+G + L A GH VVQ LV+ GA +D D TPL A G + V YLV++
Sbjct: 1168 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1225
Score = 110 bits (275), Expect = 2e-23
Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)
Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
+V V +L+ G ++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 904 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 963
Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 964 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1021
Query: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1022 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1079
Query: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1080 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1134
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
K+G TPL +A+ GH V+ L+ GA + + D ++ L A KGH VVQYLV+E
Sbjct: 1135 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1192
Score = 82.4 bits (202), Expect = 5e-15
Identities = 66/226 (29%), Positives = 100/226 (44%), Gaps = 37/226 (16%)
Query: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
+TALT A G E+ +L+ A + +++G PL AA GH +V +LL++G D+
Sbjct: 1072 ETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVN 1131
Query: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
S++ TPL +A G V+ LL++GA + + LS A G+ +++ L+
Sbjct: 1132 L-SDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1190
Query: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQG 1235
GA I+ K G +PL LAA F G
Sbjct: 1191 EEGAAIDQT--DKNGRTPLDLAA----------------------------------FYG 1214
Query: 1236 RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGA 1281
AE V L+++ A +EH +G+ PL A V LL KGA
Sbjct: 1215 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGA 1260
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)
Query: 148 ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
AL AAG GKL + G A RR + CA + + R+ E +
Sbjct: 1074 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1133
Query: 205 DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
D + L A +G ++ V LL +G +++ +EG S L AC G+ + Q L+
Sbjct: 1134 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1193
Query: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
A + D+ +K TPL A+ G + V L+ A + +G L A +V
Sbjct: 1194 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1252
Query: 322 KVLLNEGANI 331
LL +GA +
Sbjct: 1253 VALLRKGAKL 1262
>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 isoform 1 [Homo sapiens]
Length = 1861
Score = 149 bits (375), Expect = 4e-35
Identities = 120/390 (30%), Positives = 189/390 (48%), Gaps = 53/390 (13%)
Query: 287 IVKLLLLHDADVNSQSATGNTA--LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLME 344
+ +LL+L A+VN ++ N A L G ++V +LL GA ++ +ENG T L
Sbjct: 915 VSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCY 974
Query: 345 AASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEA----GADQE- 399
AA+AGH+++ +L G ++ H ++ + AL + +GH D++++LL G Q
Sbjct: 975 AAAAGHMKLVCLLTKKGVRVD-HLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPG 1033
Query: 400 --HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSF-----ESPLTLAACGGHVE 452
K+ + AL A GH V + LL + + + E+ LT AA G +E
Sbjct: 1034 TLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLE 1093
Query: 453 LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLA 512
+ LL+ GA + N G PL AAR+GH ++V LLL +G ++N ++ +
Sbjct: 1094 VCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR------- 1146
Query: 513 CCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
TPLM A+ EGHL V++LL+ GA + + G +AL
Sbjct: 1147 ------------------------TPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSAL 1182
Query: 573 TYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATA 632
++AC GH V L++ GA ++ + GRTPL AA G TV +L+ KGA +
Sbjct: 1183 SWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHV-- 1240
Query: 633 NNDHT---VVSLACAGGHLAVVELLLAHGA 659
DH+ + A + +VV LL GA
Sbjct: 1241 --DHSGMRPLDRAIGCRNTSVVVALLRKGA 1268
Score = 139 bits (349), Expect = 5e-32
Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 21/327 (6%)
Query: 381 YKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMD--GHVEVARLLLDSGAQVNMPADSF 438
Y ++ + R L+ GA+ ++T+ ++ A + GH EV LLL+ GA ++ +++
Sbjct: 909 YTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG 968
Query: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA------ 492
+ L AA GH++L LL ++G ++ ++ +G L+ +A GH +++ LL
Sbjct: 969 MTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPG 1028
Query: 493 --QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS--------TPLMEA 542
Q + + + ALT A G S V L+ + E+ + T L A
Sbjct: 1029 PPQPGTL--RKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAA 1086
Query: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 602
+ G LE+ + LL GA V T G L A GH + +LL+ G D+ + GR
Sbjct: 1087 AGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGR 1146
Query: 603 TPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPT 662
TPLM AA GHL TV+FL+SKGA ++ + + +S AC GH AVV+ L+ GA
Sbjct: 1147 TPLMVAACEGHLSTVEFLLSKGAALS-SLDKEGLSALSWACLKGHRAVVQYLVEEGAAID 1205
Query: 663 HRLKDGSTMLIEAAKGGHTNVVSYLLD 689
K+G T L AA G V YL++
Sbjct: 1206 QTDKNGRTPLDLAAFYGDAETVLYLVE 1232
Score = 131 bits (330), Expect = 7e-30
Identities = 117/389 (30%), Positives = 177/389 (45%), Gaps = 26/389 (6%)
Query: 217 DVNAVRKLLDEGRSVNEHTE--EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT 274
+V R L+ G +VN TE +LC+ G+ E+ +LL A ++ G +T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENG-MT 970
Query: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL----NEGAN 330
L A++ G++ +V LL V+ G AL ++ G DI++ LL + G
Sbjct: 971 ALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPP 1030
Query: 331 IEDHNENGHT---PLMEAASAGHVEVARVLL----DHGAGINTHSNEFKESALTLACYKG 383
H L AAS GH V + LL +H +N + E+ALT A +G
Sbjct: 1031 QPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRG 1090
Query: 384 HLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
L++ LL GA L A GH ++ RLLL+ G VN+ +PL
Sbjct: 1091 KLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLM 1150
Query: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
+AAC GH+ L+ +GA L ++ EG + L A +GH +V L+ +GA I+ QT++
Sbjct: 1151 VAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAID-QTDK 1209
Query: 504 TQETALTLACCGGFSEVADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGAN 560
T L LA G +E +L++ GA IE PL A + +V LL GA
Sbjct: 1210 NGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVVVALLRKGAK 1269
Query: 561 VHATTATGDTALTYACENGHTDVADVLLQ 589
+ G+ A +A D+ +LLQ
Sbjct: 1270 L------GNAA--WAMATSKPDILIILLQ 1290
Score = 129 bits (323), Expect = 5e-29
Identities = 96/326 (29%), Positives = 146/326 (44%), Gaps = 45/326 (13%)
Query: 216 GDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDIT- 274
G V LL+ G ++ +E G + LC A +AG+ +L +L V+ KG
Sbjct: 946 GHEEVVTLLLEFGACLDGTSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCAL 1005
Query: 275 --------------------------------------PLMAASSGGYLDIVKLLL---- 292
L AA+S G+ +V+ LL
Sbjct: 1006 VHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK 1065
Query: 293 LHDADVN-SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
H+ +VN + + G TALT A G +++ ++LL GA + N G PL AA GH
Sbjct: 1066 EHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHW 1125
Query: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
++ R+LL+ G +N + + + AC +GHL V FLL GA E +AL
Sbjct: 1126 QIVRLLLERGCDVNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSW 1184
Query: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG 471
AC+ GH V + L++ GA ++ + +PL LAA G E L+E+GA +E V+ G
Sbjct: 1185 ACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSG 1244
Query: 472 YTPLMEAAREGHEEMVALLLAQGANI 497
PL A + +V LL +GA +
Sbjct: 1245 MRPLDRAIGCRNTSVVVALLRKGAKL 1270
Score = 120 bits (302), Expect = 1e-26
Identities = 140/497 (28%), Positives = 221/497 (44%), Gaps = 66/497 (13%)
Query: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILL-- 1108
T N TAL A A GH +LV +L + +++H DKKG L+ +A GH +++ LL
Sbjct: 964 TSENGMTALCYAAAAGHMKLVCLLTKKGVRVDHLDKKGQCALVHSALRGHGDILQYLLTC 1023
Query: 1109 ------DKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR---NVSD---- 1155
+ G + + L+ A S G VV LL G KEH N +D
Sbjct: 1024 EWSPGPPQPGTL--RKSHALQQALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDTLWG 1079
Query: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSD 1215
T L+ AA G + + ++LL GA + SRT ++ G+ PL AA GH V+LLL+ G D
Sbjct: 1080 ETALTAAAGRGKLEVCELLLGHGAAV-SRT-NRRGVPPLFCAARQGHWQIVRLLLERGCD 1137
Query: 1216 INAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1275
+N + R + AC +G V LL + A + K GL+ L A G+ V +
Sbjct: 1138 VNLSDKQGRTPLMVAAC-EGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQY 1196
Query: 1276 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNG 1335
L+++GA ++ + T L +AA G + L+ +GA I+ + G PL A
Sbjct: 1197 LVEEGAAID--QTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGC 1254
Query: 1336 GHFDVVQLLVQAGADVDAA--------DNRKITPLMSAFRKGHVKVVQYLVKEVNQ---- 1383
+ VV L++ GA + A + I L +G+V + +KE Q
Sbjct: 1255 RNTSVVVALLRKGAKLGNAAWAMATSKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQY 1314
Query: 1384 ----FPSD--IECMRYIATITDKEL--LKKCHQCVETIVKAKDQQAAEANKNASILLKEL 1435
FP + E MR + L +C + K D AE + ++ LK
Sbjct: 1315 ALRKFPREGFGEDMRPFNELRVSLYLNLSRCRR------KTNDFGMAEEFASKALELKPK 1368
Query: 1436 DLE------KSREESRK--QALAAKRE-------KRKEKRKKKKEEQKRKQEEDEENKPK 1480
E +++ SR+ ALA +E ++ KR + E++ KQ + + + K
Sbjct: 1369 SYEAFYARARAKRNSRQFVAALADLQEAVKLCPTNQEVKRLLARVEEECKQLQRSQQQ-K 1427
Query: 1481 ENSELPEDEDEEENDED 1497
+ LP ++ EN+ED
Sbjct: 1428 QQGPLPAPLNDSENEED 1444
Score = 117 bits (293), Expect = 1e-25
Identities = 96/298 (32%), Positives = 140/298 (46%), Gaps = 12/298 (4%)
Query: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
L + + GH VV +LL+ G ++ SE T L A + G ++V LL +G +H
Sbjct: 939 LCVQSHLGHEEVVTLLLEFGACLDGTSENGM-TALCYAAAAGHMKLVCLLTKKGVRVDHL 997
Query: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGIS-----PLMLAAMNGHVPAV 1206
+ L +A G+ +I++ LL L S L AA GH V
Sbjct: 998 DKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASMGHSSVV 1057
Query: 1207 KLLLDMGSDINAQIETNRN----TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLM 1262
+ LL M + ++ TALT A +G+ EV LLL A V + G+ PL
Sbjct: 1058 QCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLF 1117
Query: 1263 EAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
AA G+ ++ R+LL++G DVN T L +AA +GH E L+ +GA + +
Sbjct: 1118 CAARQGHWQIVRLLLERGCDVNLSDKQGR--TPLMVAACEGHLSTVEFLLSKGAALSSLD 1175
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
K+G + L A GH VVQ LV+ GA +D D TPL A G + V YLV++
Sbjct: 1176 KEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEK 1233
Score = 110 bits (275), Expect = 2e-23
Identities = 96/298 (32%), Positives = 145/298 (48%), Gaps = 26/298 (8%)
Query: 1100 HVGVVEILLDKGGDIEAQSERTKDTPLSLACSG-GRQEVVDLLLARGANKEHRNVSDYTP 1158
+V V +L+ G ++ ++E + P+ S G +EVV LLL GA + + + T
Sbjct: 912 NVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTA 971
Query: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMG-SDIN 1217
L AA+ G++ ++ +L G ++ K G L+ +A+ GH ++ LL S
Sbjct: 972 LCYAAAAGHMKLVCLLTKKGVRVDHL--DKKGQCALVHSALRGHGDILQYLLTCEWSPGP 1029
Query: 1218 AQIETNRNT-----ALTLACFQGRAEVVSLLLDRKANVEHRAKT-------GLTPLMEAA 1265
Q T R + ALT A G + VV LL + EH + G T L AA
Sbjct: 1030 PQPGTLRKSHALQQALTAAASMGHSSVVQCLLGMEK--EHEVEVNGTDTLWGETALTAAA 1087
Query: 1266 SGGYAEVGRVLLDKGADV---NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRN 1322
G EV +LL GA V N VP L AA +GH++ LL+ RG +++ +
Sbjct: 1088 GRGKLEVCELLLGHGAAVSRTNRRGVPP-----LFCAARQGHWQIVRLLLERGCDVNLSD 1142
Query: 1323 KKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
K+G TPL +A+ GH V+ L+ GA + + D ++ L A KGH VVQYLV+E
Sbjct: 1143 KQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEE 1200
Score = 53.1 bits (126), Expect = 3e-06
Identities = 52/190 (27%), Positives = 81/190 (42%), Gaps = 7/190 (3%)
Query: 148 ALLEAAGIGKLSTAD---GKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQV 204
AL AAG GKL + G A RR + CA + + R+ E +
Sbjct: 1082 ALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLS 1141
Query: 205 DTRS---LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMH 261
D + L A +G ++ V LL +G +++ +EG S L AC G+ + Q L+
Sbjct: 1142 DKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEG 1201
Query: 262 ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIV 321
A + D+ +K TPL A+ G + V L+ A + +G L A +V
Sbjct: 1202 AAI-DQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTSVV 1260
Query: 322 KVLLNEGANI 331
LL +GA +
Sbjct: 1261 VALLRKGAKL 1270
>gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
Length = 871
Score = 148 bits (374), Expect = 6e-35
Identities = 138/415 (33%), Positives = 188/415 (45%), Gaps = 52/415 (12%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L AC GD R+LL+ G + E E G A AG A V G
Sbjct: 13 LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
AA++G V V+ GNTAL +A AGG +V+ LL G
Sbjct: 59 ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
A++ N G + LM+AA GHV VA +LLDHGA +N N S LT+A GHL +V
Sbjct: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
Query: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434
+ LLEAGA D H + E TALM A GH V RLL++ GA N
Sbjct: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
Query: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
A + SPL LAA G + +A L+E+GAN + ++ T A H ++V L
Sbjct: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
Query: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549
EE + + A G F V + + + + L +TPLM A+ G L
Sbjct: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
Query: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603
LV+ L+ A+V + G TAL A +G+ ++ LL GAD+ ++ G T
Sbjct: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 132 bits (333), Expect = 3e-30
Identities = 110/338 (32%), Positives = 161/338 (47%), Gaps = 26/338 (7%)
Query: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
V +D E+ + TAL A AGGHE LV L+ R A + R+ G++ L+ AA GHV V
Sbjct: 69 VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
Query: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
+LLD G D+ AQ+ R + L++A GG VV LLL GA +H + S L L S
Sbjct: 128 HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
Query: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
L I+ LM A +GH V+LL++ G+D N T
Sbjct: 186 --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
Query: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
+ L LA GR V L+++ AN +H + T A + ++ LD V
Sbjct: 226 WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
Query: 1285 APPVPSSRDTALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
R + A G+++ E+ +H+++ N G TPL LA+ G +VQL
Sbjct: 285 PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
Query: 1344 LVQAGADVDAADN-RKITPLMSAFRKGHVKVVQYLVKE 1380
LV+ ADVD D+ T LM A G+ ++V+YL+ +
Sbjct: 345 LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
Score = 126 bits (316), Expect = 3e-28
Identities = 121/386 (31%), Positives = 173/386 (44%), Gaps = 27/386 (6%)
Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTH- 367
L AC G + + LL GA + E G P A AG EVA +
Sbjct: 13 LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAG-AEVAGPGAAAAGAVGAPV 69
Query: 368 ----SNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
S+E +AL A GH +VRFLL GA + +ALM+A GHV VA L
Sbjct: 70 PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
Query: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEG------------ 471
LLD GA VN S LT+A+ GGH+ + LL+E GA ++ + G
Sbjct: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
Query: 472 --YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGA 529
T LM A + GHE +V LL+ GA+ N + L LA G VA L++ GA
Sbjct: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
Query: 530 D---IELGCSTPLMEASQEGHLELVKYL-LASGANVHATTATGDTALTYACENGHTD-VA 584
+ + + T A H +LV YL + + +A + G+ V
Sbjct: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
Query: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
++ + + + + G TPLM AA G L VQ L+ + A+V++ + + T + A
Sbjct: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
Query: 645 GGHLAVVELLLAHGADPTHRLKDGST 670
G+ +V+ LL GAD T R K+G T
Sbjct: 370 HGNKEIVKYLLNQGADVTLRAKNGYT 395
Score = 91.3 bits (225), Expect = 1e-17
Identities = 81/295 (27%), Positives = 128/295 (43%), Gaps = 61/295 (20%)
Query: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKG--------------FTPLILAATAGHVG 1102
+ LT+A GGH +V +L+ A ++H G T L+ A GH
Sbjct: 146 SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEA 205
Query: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
VV +L++ G D + +PL LA GR V L+ +GAN +H +V + T +A
Sbjct: 206 VVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVA 265
Query: 1163 ASGGYVNIIKIL----------------------LNAG-------------AEINSRTGS 1187
+ +++ L L G + +N G
Sbjct: 266 LDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGD 325
Query: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247
G +PLMLAA+ G + V+LL++ +D++ Q + TAL A + G E+V LL++
Sbjct: 326 --GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQG 383
Query: 1248 ANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAPPVPSSR 1292
A+V RAK G T L+ + E+ R+L DKG + PP+P S+
Sbjct: 384 ADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSK 438
Score = 88.6 bits (218), Expect = 7e-17
Identities = 75/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)
Query: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534
L+ A +G E LL GA A+ E A A GA + +
Sbjct: 13 LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
Query: 535 CS-----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
CS T L A+ GH LV++LL GA+V++ G +AL A GH VA +LL
Sbjct: 73 CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
Query: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-------------DH 636
GAD+ ++ G + L A+R GHL V+ L+ GA V+ + D
Sbjct: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
Query: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTNVVSYLLD 689
T + A GH AVV LL+ GADP H + G + L+ AA G V L++
Sbjct: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
Score = 66.6 bits (161), Expect = 3e-10
Identities = 57/156 (36%), Positives = 73/156 (46%), Gaps = 7/156 (4%)
Query: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1286
L AC QG E LL+ A A+ G P A G G GA V AP
Sbjct: 13 LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
Query: 1287 PVPSSRD---TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
PV S + TAL AA GH L+ RGA ++ RN G + L A+ GH V L
Sbjct: 70 PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
Query: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
L+ GADV+A + + L A R GH+ VV+ L++
Sbjct: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
Score = 49.7 bits (117), Expect = 4e-05
Identities = 41/127 (32%), Positives = 57/127 (44%), Gaps = 6/127 (4%)
Query: 572 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRAT 631
L AC+ G T+ A LL+ GA +E G P A AG + GA
Sbjct: 13 LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
Query: 632 ANND----HTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
+ +T + A AGGH +V LL GA R G + L++AA+ GH +V L
Sbjct: 71 VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
Query: 688 LDYPNNV 694
LD+ +V
Sbjct: 131 LDHGADV 137
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 140 bits (353), Expect = 2e-32
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
Query: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
Query: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
Query: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
Query: 561 VHATTATGDTA 571
+ A AT TA
Sbjct: 419 IDAYIATHPTA 429
Score = 119 bits (299), Expect = 3e-26
Identities = 88/258 (34%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
Query: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
Query: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Query: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
VK L+ A+ + G TAL + +V +L+ GA +E ++ G TPL AA+
Sbjct: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
Query: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
+G L ++FL GA++N ++N + AC H VVE LL+ GAD KDG
Sbjct: 233 SGQLEALRFLAKYGADINTQASDNASALYE-ACKNEHEEVVEFLLSQGADANKTNKDGLL 291
Query: 671 MLIEAAKGGHTNVVSYLL 688
L A+K G+ +V LL
Sbjct: 292 PLHIASKKGNYRIVQMLL 309
Score = 119 bits (298), Expect = 4e-26
Identities = 110/397 (27%), Positives = 181/397 (45%), Gaps = 49/397 (12%)
Query: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQE---------------------------HK 401
+E+A+ LA +GHLD + LL+AGA+ + H
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 402 TDEMH------TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAA 455
D H TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
Query: 456 LLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG 515
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIASKK 299
Query: 516 GFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA------- 566
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
Query: 567 --TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKG 624
+AL +A N + ++LLQ GAD + +PL+ A R G L T+Q L+ G
Sbjct: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLLDHG 416
Query: 625 ANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGAD 660
AN++ A + ++ A L++++ L+ G D
Sbjct: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
Score = 112 bits (279), Expect = 6e-24
Identities = 90/309 (29%), Positives = 152/309 (49%), Gaps = 23/309 (7%)
Query: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
I+ R + T + LA GH+ + LL G + + S ++++TPL AC E V +
Sbjct: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKI 175
Query: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
L+ A+ HR +T L + S + +++IL++ GA++ S+ + GI+PL +AA +
Sbjct: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK--NAYGITPLFVAAQS 233
Query: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
G + A++ L G+DIN Q N +AL AC EVV LL + A+ K GL P
Sbjct: 234 GQLEALRFLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLP 292
Query: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
L A+ G + ++LL + + S + L +AA++ H + E L+ A DV
Sbjct: 293 LHIASKKGNYRIVQMLLPV---TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDV 347
Query: 1321 R-----------NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
+ ++ L+ A + +LL+Q GAD + I+PL+ A R G
Sbjct: 348 NTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHG 404
Query: 1370 HVKVVQYLV 1378
++ +Q L+
Sbjct: 405 CLRTMQLLL 413
Score = 111 bits (277), Expect = 1e-23
Identities = 117/404 (28%), Positives = 177/404 (43%), Gaps = 26/404 (6%)
Query: 964 PQIAITGHDQGLLVQEPDGLMVAT---PAQTLTDTLDDLIA-AVSTRVPTGSNSSSQTTE 1019
P A G QG++ + L + PA L + D A+ T + G N + E
Sbjct: 30 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE 89
Query: 1020 CLTPESCSQTTSNVAS-QSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARD 1078
P + V + + YP ID T +TA+ LA GH + + L+
Sbjct: 90 GWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAG 147
Query: 1079 AKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVV 1138
A+ + +K TPL A + V+IL+ D + R T L + S EV+
Sbjct: 148 AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVM 206
Query: 1139 DLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 1198
+L++ GA E +N TPL +AA G + ++ L GA+IN++ S L A
Sbjct: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASD--NASALYEAC 264
Query: 1199 MNGHVPAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKT 1256
N H V+ LL G+D N +TN++ L L A +G +V +LL + R ++
Sbjct: 265 KNEHEEVVEFLLSQGADAN---KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RS 320
Query: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP-------SSRDTALTIAADKGHYKFCE 1309
G++PL AA + EV LL DVN P P R +AL A + E
Sbjct: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
Query: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
LL+ GA N+ +PL +A G +QLL+ GA++DA
Sbjct: 381 LLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
Score = 100 bits (250), Expect = 1e-20
Identities = 76/255 (29%), Positives = 119/255 (46%), Gaps = 6/255 (2%)
Query: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 1183
PL A G +E + ++ G N N + PL AA G V +K+L A I+
Sbjct: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
RT + + + LA GH+ + LL G++ + +R T L AC + AE V +L
Sbjct: 120 RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176
Query: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
+ A+ HR G T L E+ S EV ++L+ GA V + T L +AA G
Sbjct: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI--TPLFVAAQSG 234
Query: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
+ L GA I+ + + L+ A H +VV+ L+ GAD + + + PL
Sbjct: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
Query: 1364 SAFRKGHVKVVQYLV 1378
A +KG+ ++VQ L+
Sbjct: 295 IASKKGNYRIVQMLL 309
Score = 66.6 bits (161), Expect = 3e-10
Identities = 57/186 (30%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 1048 DAHTE-SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
D +T+ S++ +AL AC HEE+V L+++ A +K G PL +A+ G+ +V++
Sbjct: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
Query: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG-------ANKEHRNVSDY--T 1157
LL + R+ +PL LA EV++ LL+ A + R D +
Sbjct: 308 LLPVTS--RTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSS 365
Query: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
L A V ++LL GA+ N ISPL++A +G + ++LLLD G++I+
Sbjct: 366 ALYFAVVNNNVYATELLLQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANID 420
Query: 1218 AQIETN 1223
A I T+
Sbjct: 421 AYIATH 426
Score = 53.9 bits (128), Expect = 2e-06
Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 35/208 (16%)
Query: 532 ELGCSTPLMEASQEGHLELVKYLLASGAN------------------------------- 560
+L + PL++A ++G E +K ++ G N
Sbjct: 54 QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
Query: 561 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
+ T +TA+ A GH D LLQAGA+ + ++ TPL KA + V
Sbjct: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
Query: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677
+ L+ A+ N N T + + + L V+++L++ GA + G T L AA+
Sbjct: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
Query: 678 GGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
G + +L Y ++ + + + S L
Sbjct: 233 SGQLEALRFLAKYGADINTQASDNASAL 260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 104,373,912
Number of Sequences: 37866
Number of extensions: 5548785
Number of successful extensions: 89004
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1107
Number of HSP's successfully gapped in prelim test: 1428
Number of HSP's that attempted gapping in prelim test: 33966
Number of HSP's gapped (non-prelim): 28798
length of query: 2542
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2423
effective length of database: 13,741,464
effective search space: 33295567272
effective search space used: 33295567272
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.