Search of human proteins with 46276887

Search of human proteins with 46276887

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]
         (848 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]             1715   0.0  
gi|46276885 WD repeat domain 78 isoform 2 [Homo sapiens]             1051   0.0  
gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]      236   7e-62
gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo sa...   129   9e-30
gi|66267730 WD repeat domain 34 [Homo sapiens]                        116   8e-26
gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a...   115   1e-25
gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform...   115   1e-25
gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform...   115   1e-25
gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo ...   102   1e-21
gi|113865883 WD repeat domain 38 [Homo sapiens]                        52   3e-06
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      49   2e-05
gi|7706657 cell division cycle 40 homolog [Homo sapiens]               48   3e-05
gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]         48   4e-05
gi|210032390 SEC13 protein isoform 2 [Homo sapiens]                    47   1e-04
gi|34335134 SEC13 protein isoform 1 [Homo sapiens]                     47   1e-04
gi|21536485 HIR histone cell cycle regulation defective homolog ...    46   1e-04
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    46   2e-04
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    46   2e-04
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    46   2e-04
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     46   2e-04
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     45   2e-04
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             45   4e-04
gi|8922301 WD repeat domain 70 [Homo sapiens]                          45   4e-04
gi|13129110 WD repeat domain 77 [Homo sapiens]                         44   5e-04
gi|45238858 WD repeat domain 44 protein [Homo sapiens]                 44   6e-04
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    43   0.001
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     43   0.001
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     43   0.001
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     43   0.001
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ...    42   0.002

>gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]
          Length = 848

 Score = 1715 bits (4442), Expect = 0.0
 Identities = 848/848 (100%), Positives = 848/848 (100%)

Query: 1   MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA 60
           MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA
Sbjct: 1   MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA 60

Query: 61  TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN 120
           TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN
Sbjct: 61  TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN 120

Query: 121 GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL 180
           GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL
Sbjct: 121 GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL 180

Query: 181 GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL 240
           GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL
Sbjct: 181 GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL 240

Query: 241 TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN 300
           TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN
Sbjct: 241 TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN 300

Query: 301 KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG 360
           KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG
Sbjct: 301 KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG 360

Query: 361 STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL 420
           STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL
Sbjct: 361 STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL 420

Query: 421 AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC 480
           AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC
Sbjct: 421 AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC 480

Query: 481 DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWPERIYQSPYGVT 540
           DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWPERIYQSPYGVT
Sbjct: 481 DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWPERIYQSPYGVT 540

Query: 541 AVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGT 600
           AVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGT
Sbjct: 541 AVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGT 600

Query: 601 TGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQ 660
           TGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQ
Sbjct: 601 TGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQ 660

Query: 661 APGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVF 720
           APGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVF
Sbjct: 661 APGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVF 720

Query: 721 LSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHIST 780
           LSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHIST
Sbjct: 721 LSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHIST 780

Query: 781 LDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRGDIMDTLL 840
           LDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRGDIMDTLL
Sbjct: 781 LDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRGDIMDTLL 840

Query: 841 GSKSNQSA 848
           GSKSNQSA
Sbjct: 841 GSKSNQSA 848


>gi|46276885 WD repeat domain 78 isoform 2 [Homo sapiens]
          Length = 545

 Score = 1051 bits (2718), Expect = 0.0
 Identities = 527/527 (100%), Positives = 527/527 (100%)

Query: 1   MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA 60
           MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA
Sbjct: 1   MTPGKHSGASARAANAGAWGYRDFRGGQKKGWWTTPQLVATMPVSPAGSHKQQNFGLNNA 60

Query: 61  TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN 120
           TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN
Sbjct: 61  TQPKKSISFFATMKATSVKGYTGANQSRMAVSKTVLIPPELKTVEKPNPNIKTTQVFDIN 120

Query: 121 GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL 180
           GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL
Sbjct: 121 GTDVTPRPLYHPDPLTGTAKPSKLLTSQEGSLGSEFISSYSLYQNTINPSTLGQFTRSVL 180

Query: 181 GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL 240
           GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL
Sbjct: 181 GSSTVSKSSVSASESIAEDLEEPSYKRERLTSFTDLQVIRAAPEKIVTKEDLEKNIEIIL 240

Query: 241 TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN 300
           TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN
Sbjct: 241 TETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDLYVERMMQTFNGAPKN 300

Query: 301 KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG 360
           KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG
Sbjct: 301 KDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANVLPKDQDQRLPG 360

Query: 361 STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL 420
           STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL
Sbjct: 361 STTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLMENIFQPKL 420

Query: 421 AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC 480
           AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC
Sbjct: 421 AAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANLERLWSFSC 480

Query: 481 DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPM 527
           DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPM
Sbjct: 481 DLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPM 527


>gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]
          Length = 699

 Score =  236 bits (602), Expect = 7e-62
 Identities = 172/603 (28%), Positives = 278/603 (46%), Gaps = 87/603 (14%)

Query: 231 DLEKNIEIILTETETLRFFDLPTVMVSVESEEAEKVTQRNKNYEVLCRNRLGNDL-YVER 289
           +LE++ E    ETE     D+P    + +  E E +T +          +L N   + ER
Sbjct: 143 NLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPK-----ERKLTNQFNFSER 197

Query: 290 MMQTFNGAPKNKDVQCDKIIMEDKGIMSTAWDLYDSYNAMELVSLSVKQSVVESSSKANV 349
             QT+N   ++++ Q +     +    +  W++YD+Y    +  L  ++   E       
Sbjct: 198 ASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAY----VEELEKQEKTKEKEKAKTP 253

Query: 350 LPKDQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMER 409
           + K   +      T   S+T  L+ +     AKI                       MER
Sbjct: 254 VAKKSGKMAMRKLTSMESQTDDLIKLSQA--AKI-----------------------MER 288

Query: 410 VLMENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIP 469
           ++ +N +                     +D+ +  K+ +   ++  E  +++        
Sbjct: 289 MVNQNTY---------------------DDIAQDFKYYD---DAADEYRDQV-------- 316

Query: 470 ANLERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWP 529
             L  LW F  D  K L+V++L WN    DL AVGYG + F +Q RG+   +S+KNP +P
Sbjct: 317 GTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQSRGMLLLYSLKNPSFP 376

Query: 530 ERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVW 589
           E ++ S  GV  +D  +  P L+AVG+++G +AIYN++   + P   SS    KH  PVW
Sbjct: 377 EYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVW 436

Query: 590 QLQWIEQDRGTTGDGKREILVSISADGRISKW-VIRKGLDCYDLMRLKRTTAASNKKGGE 648
           Q++W + D     +       S+S+DGRI  W ++++ L   D+++LK        +G  
Sbjct: 437 QVKWQKDDMDQNLN-----FFSVSSDGRIVSWTLVKRKLVHIDVIKLK-------VEGST 484

Query: 649 KEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVY 708
            E  +   +     G  F FH +   ++L GTEEG I+KCS SY+ Q+LDTY  H   V 
Sbjct: 485 TEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHNMSVD 544

Query: 709 KVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAA-AN 767
            V+WNP+   VF+SCS+DW V IW    +K  +  Y   S V DVAW+P SS +FAA   
Sbjct: 545 TVSWNPYHTKVFMSCSSDWTVKIW-DHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTT 603

Query: 768 ENRVEIWDLHISTLDPLIVN-TANPGIKFTTILFAKQTDCLLVGDSDGQVSVYE----LR 822
           + +  I+DL I+  + +     A    + T + F      ++VGD  G +   +    LR
Sbjct: 604 DGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSPNLR 663

Query: 823 NMP 825
            MP
Sbjct: 664 KMP 666


>gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo
           sapiens]
          Length = 638

 Score =  129 bits (325), Expect = 9e-30
 Identities = 122/480 (25%), Positives = 196/480 (40%), Gaps = 64/480 (13%)

Query: 352 KDQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVL 411
           +D D   P    E   E +   D EN   A  HE  E+    IL S++F        R++
Sbjct: 174 EDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIV 233

Query: 412 MENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPAN 471
                  + A   Q+ +  +    + ED               KE E +  A+ S     
Sbjct: 234 -------ERALSEQINIFFDYSGRDLED---------------KEGEIQAGAKLSLNRQF 271

Query: 472 LERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF-GFKEQKRGLACCWSIK-NPMWP 529
            +  WS      K   VS L W+   P+LL   Y +      +  G+A  W++K     P
Sbjct: 272 FDERWS------KHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTP 325

Query: 530 ERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVW 589
           E ++     V +  F+   PNL+  G ++G I +++ RSN   PV  +  S   H  PV+
Sbjct: 326 EYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVY 385

Query: 590 QLQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEK 649
            +  +       G      L+SIS DG+I  W +       D M L             K
Sbjct: 386 CVNVV-------GTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVH-----------K 427

Query: 650 EKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHK-CSCSYNEQYLDTYRGHKGPVY 708
           + K  A+ S        +F   D N ++ G+EEG ++  C         + + GH+GP+ 
Sbjct: 428 QSKAVAVTS-------MSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPIT 480

Query: 709 KVTWNP------FCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYI 762
            +  +       F H +F++ S DW V +W  +N KP  SF      VYDV WSP    +
Sbjct: 481 GIHCHAAVGAVDFSH-LFVTSSFDWTVKLWTTKNNKPLYSFEDNADYVYDVMWSPTHPAL 539

Query: 763 FAAAN-ENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYEL 821
           FA  +   R+++W+L+  T  P    +         + +      + VGDS+GQ+ +Y++
Sbjct: 540 FACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDV 599


>gi|66267730 WD repeat domain 34 [Homo sapiens]
          Length = 536

 Score =  116 bits (291), Expect = 8e-26
 Identities = 93/369 (25%), Positives = 163/369 (44%), Gaps = 47/369 (12%)

Query: 484 KGLNVSSLAWNKTNPDLLAVGYGHF--GFKEQKRGLACCWSIKN----PMWPERIYQSPY 537
           +GL+V+S++WN T   ++A  YG    G     +   C W++      P  P  + + P 
Sbjct: 160 QGLHVTSISWNSTG-SVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPS 218

Query: 538 GVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQD 597
            V  + F    P+ +A G ++G + ++++    +  +  +  +   H  PV Q+ W+ + 
Sbjct: 219 AVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEP 278

Query: 598 RGTTGDGKREILVSISADGRISKWV--------IRKGLDCYDLMRLKRTTAASNKKGGEK 649
               G   R  ++S++ DG++  W         + +G     + +L R+T       GE 
Sbjct: 279 ----GHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALV-MQQLPRSTKLKKHPRGET 333

Query: 650 EKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLD----------- 698
           E    A+          AF   D  +++ GTE G   KCS +  E  L            
Sbjct: 334 EVGATAV----------AFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAP 383

Query: 699 ---TYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAW 755
              T+  H GP+Y V+ +PF  ++FLS   D  V ++      P  S   +   ++ V W
Sbjct: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRW 443

Query: 756 SPKSSYIFAAAN-ENRVEIWDLHISTLDP--LIVNTANPGIKFTTILFAKQTDCLLVGDS 812
           SP    +FAAA+ +  V+++DL  S+  P  LI  T +    +     ++QT  L  GD+
Sbjct: 444 SPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDA 503

Query: 813 DGQVSVYEL 821
            G V V++L
Sbjct: 504 QGTVKVWQL 512


>gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a
           [Homo sapiens]
          Length = 645

 Score =  115 bits (289), Expect = 1e-25
 Identities = 115/483 (23%), Positives = 206/483 (42%), Gaps = 72/483 (14%)

Query: 353 DQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLM 412
           ++D+ +  S   ++SE  +    + V  A   E  E+    IL S++F   L F +R + 
Sbjct: 183 EEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEF---LIFFDRTI- 238

Query: 413 ENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANL 472
             + +  LA              E  D+       E+EE   K+ + +  A  S      
Sbjct: 239 -RVIERALA--------------EDSDIFFDYSGRELEE---KDGDVQAGANLSFNRQFY 280

Query: 473 ERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF-GFKEQKRGLACCWSIK-NPMWPE 530
           +  WS      K   V+ + W+   P+L+   Y +      +  G+A  W++K     PE
Sbjct: 281 DEHWS------KHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPE 334

Query: 531 RIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQ 590
            ++     V +V F+   PNL+  G ++G I +++ RS+   PV  +  S   H  PV+ 
Sbjct: 335 YVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYC 394

Query: 591 LQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKE 650
           +  +       G      L+++S DG++  W +       D++                +
Sbjct: 395 VNVV-------GTQNAHNLITVSTDGKMCSWSL-------DML-------------STPQ 427

Query: 651 KKDEALISRQAP----GMCFAFHPKDTNIYLAGTEEGHIHK-CSCSYNEQYLDTYRGHKG 705
           +  E + ++  P    GM  AF   D N ++ G+EEG ++  C         + + GH+G
Sbjct: 428 ESMELVYNKSKPVAVTGM--AFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQG 485

Query: 706 PVYKVTWN------PFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKS 759
           PV  +  +       F H +F++ S DW V +W  ++ KP  SF      VYDV WSP  
Sbjct: 486 PVTGINCHMAVGPIDFSH-LFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVH 544

Query: 760 SYIFAAAN-ENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSV 818
             +FA  +   R+++W+L+  T  P              + +A+    + VGDS+G++ V
Sbjct: 545 PALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWV 604

Query: 819 YEL 821
           Y++
Sbjct: 605 YDV 607


>gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform c
           [Homo sapiens]
          Length = 608

 Score =  115 bits (289), Expect = 1e-25
 Identities = 115/483 (23%), Positives = 206/483 (42%), Gaps = 72/483 (14%)

Query: 353 DQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLM 412
           ++D+ +  S   ++SE  +    + V  A   E  E+    IL S++F   L F +R + 
Sbjct: 146 EEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEF---LIFFDRTI- 201

Query: 413 ENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANL 472
             + +  LA              E  D+       E+EE   K+ + +  A  S      
Sbjct: 202 -RVIERALA--------------EDSDIFFDYSGRELEE---KDGDVQAGANLSFNRQFY 243

Query: 473 ERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF-GFKEQKRGLACCWSIK-NPMWPE 530
           +  WS      K   V+ + W+   P+L+   Y +      +  G+A  W++K     PE
Sbjct: 244 DEHWS------KHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPE 297

Query: 531 RIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQ 590
            ++     V +V F+   PNL+  G ++G I +++ RS+   PV  +  S   H  PV+ 
Sbjct: 298 YVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYC 357

Query: 591 LQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKE 650
           +  +       G      L+++S DG++  W +       D++                +
Sbjct: 358 VNVV-------GTQNAHNLITVSTDGKMCSWSL-------DML-------------STPQ 390

Query: 651 KKDEALISRQAP----GMCFAFHPKDTNIYLAGTEEGHIHK-CSCSYNEQYLDTYRGHKG 705
           +  E + ++  P    GM  AF   D N ++ G+EEG ++  C         + + GH+G
Sbjct: 391 ESMELVYNKSKPVAVTGM--AFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQG 448

Query: 706 PVYKVTWN------PFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKS 759
           PV  +  +       F H +F++ S DW V +W  ++ KP  SF      VYDV WSP  
Sbjct: 449 PVTGINCHMAVGPIDFSH-LFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVH 507

Query: 760 SYIFAAAN-ENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSV 818
             +FA  +   R+++W+L+  T  P              + +A+    + VGDS+G++ V
Sbjct: 508 PALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWV 567

Query: 819 YEL 821
           Y++
Sbjct: 568 YDV 570


>gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform b
           [Homo sapiens]
          Length = 628

 Score =  115 bits (289), Expect = 1e-25
 Identities = 115/483 (23%), Positives = 206/483 (42%), Gaps = 72/483 (14%)

Query: 353 DQDQRLPGSTTEKNSETSSLMDIENVILAKIHEDEEDHSDAILKSDKFHQDLFFMERVLM 412
           ++D+ +  S   ++SE  +    + V  A   E  E+    IL S++F   L F +R + 
Sbjct: 166 EEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEF---LIFFDRTI- 221

Query: 413 ENIFQPKLAAYRQLPVLKEPEPEEPEDVLESAKHEEVEEESKKEEEEEIHAEESTIPANL 472
             + +  LA              E  D+       E+EE   K+ + +  A  S      
Sbjct: 222 -RVIERALA--------------EDSDIFFDYSGRELEE---KDGDVQAGANLSFNRQFY 263

Query: 473 ERLWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF-GFKEQKRGLACCWSIK-NPMWPE 530
           +  WS      K   V+ + W+   P+L+   Y +      +  G+A  W++K     PE
Sbjct: 264 DEHWS------KHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPE 317

Query: 531 RIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQ 590
            ++     V +V F+   PNL+  G ++G I +++ RS+   PV  +  S   H  PV+ 
Sbjct: 318 YVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYC 377

Query: 591 LQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKE 650
           +  +       G      L+++S DG++  W +       D++                +
Sbjct: 378 VNVV-------GTQNAHNLITVSTDGKMCSWSL-------DML-------------STPQ 410

Query: 651 KKDEALISRQAP----GMCFAFHPKDTNIYLAGTEEGHIHK-CSCSYNEQYLDTYRGHKG 705
           +  E + ++  P    GM  AF   D N ++ G+EEG ++  C         + + GH+G
Sbjct: 411 ESMELVYNKSKPVAVTGM--AFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQG 468

Query: 706 PVYKVTWN------PFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKS 759
           PV  +  +       F H +F++ S DW V +W  ++ KP  SF      VYDV WSP  
Sbjct: 469 PVTGINCHMAVGPIDFSH-LFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVH 527

Query: 760 SYIFAAAN-ENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSV 818
             +FA  +   R+++W+L+  T  P              + +A+    + VGDS+G++ V
Sbjct: 528 PALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWV 587

Query: 819 YEL 821
           Y++
Sbjct: 588 YDV 590


>gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo
           sapiens]
          Length = 605

 Score =  102 bits (255), Expect = 1e-21
 Identities = 80/303 (26%), Positives = 136/303 (44%), Gaps = 32/303 (10%)

Query: 491 LAWNKTNPDLLAVGYGHFGFKEQKRGLAC---CWSIKNPMWPERIYQSPYGVTAVDFSIG 547
           L+W+      LAV Y    F+    G++     W ++NP  PE   +    +  ++F+  
Sbjct: 168 LSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLENPNKPELALKPSSPLVTLEFNPK 227

Query: 548 APNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGTTGDGKRE 607
             ++L  G +NG IA ++ R  S V  L + ES   H  PV+   W++   GT       
Sbjct: 228 DSHVLLGGCYNGQIACWDTRKGSLVAELSTIES--SHRDPVYGTIWLQSKTGTE------ 279

Query: 608 ILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFA 667
              S S DG++  W IRK  +  +++ L  T         +KE+ + AL       +   
Sbjct: 280 -CFSASTDGQVMWWDIRKMSEPTEVVILDIT---------KKEQLENAL-----GAISLE 324

Query: 668 FHPKDTNIYLAGTEEGHIHKCSCSYN---EQYLDTYRGHKGPVYKVTWNPFCHDVFLSCS 724
           F       ++ GTE+G +  C+       E+ + T+ GH GP+Y +  NPF    FL+  
Sbjct: 325 FESTLPTKFMVGTEQGIVISCNRKAKTSAEKIVCTFPGHHGPIYALQRNPFYPKNFLTV- 383

Query: 725 ADWGVIIWQQENVKPSLSFYP-ATSVVYDVAWSP-KSSYIFAAANENRVEIWDLHISTLD 782
            DW   IW +++ + S+ +     + + D AWSP + +  F    +  ++IWD      D
Sbjct: 384 GDWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLDIWDFMFEQCD 443

Query: 783 PLI 785
           P +
Sbjct: 444 PTL 446


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 43/156 (27%), Positives = 70/156 (44%), Gaps = 6/156 (3%)

Query: 667 AFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSAD 726
           AF P D  + L G+E+G ++    + + Q L    GH GPV    ++P  H +F S S D
Sbjct: 28  AFSP-DGQMLLTGSEDGCVYGWE-TRSGQLLWRLGGHTGPVKFCRFSPDGH-LFASASCD 84

Query: 727 WGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHISTLDPLIV 786
             V +W     K           V  V++SP S  + +   + RV +WD+    +  L+V
Sbjct: 85  CTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLV 144

Query: 787 NTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELR 822
              +      +  F+   +CL  G  D  V +++LR
Sbjct: 145 GHRD---SIQSSDFSPTVNCLATGSWDSTVHIWDLR 177


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 32/122 (26%), Positives = 56/122 (45%), Gaps = 9/122 (7%)

Query: 663 GMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYR---GHKGPVYKVTWNPFCHDV 719
           G    + P+ T   L G  + +IH  + +    +    R   GH   V  + W+P  + V
Sbjct: 217 GFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTV 276

Query: 720 FLSCSADWGVIIWQQENVKPSLSFYPATSVVYD-----VAWSPKSSYIFAAANENRVEIW 774
           F SCSAD  + IW      PS +    T+  +D     ++WS +  ++ +  ++  ++IW
Sbjct: 277 FASCSADASIRIW-DIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKIW 335

Query: 775 DL 776
           DL
Sbjct: 336 DL 337



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 28/130 (21%), Positives = 58/130 (44%), Gaps = 6/130 (4%)

Query: 699 TYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKP----SLSFYPATSVVYDVA 754
           ++ GH G  + + W+P      L+      + +W   +          F   T  V D+ 
Sbjct: 209 SFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDLQ 268

Query: 755 WSPKSSYIFAAANENR-VEIWDLHISTLDPLIVNTANPGIKFTTIL-FAKQTDCLLVGDS 812
           WSP  + +FA+ + +  + IWD+  +     ++ TA        ++ ++++   LL G  
Sbjct: 269 WSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGD 328

Query: 813 DGQVSVYELR 822
           DG + +++LR
Sbjct: 329 DGALKIWDLR 338



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 9/103 (8%)

Query: 697 LDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVI-IWQQENVK---PSLSFYPATSVVYD 752
           L T   H G V  ++W+    + FL    D G + IW     K   P  +F    + V  
Sbjct: 301 LTTATAHDGDVNVISWSR--REPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTS 358

Query: 753 VAWSPKSSYIFAAAN-ENRVEIWDLHISTLDPLIVNT-ANPGI 793
           V W P+ S +FAA+  ++++  WDL +   DP   +  A+PG+
Sbjct: 359 VEWHPQDSGVFAASGADHQITQWDLAVER-DPEAGDVEADPGL 400



 Score = 30.4 bits (67), Expect = 7.2
 Identities = 23/84 (27%), Positives = 40/84 (47%), Gaps = 14/84 (16%)

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNVRS-NSNVPVLDSSESPQKHLGPVWQLQWIEQD 597
           V  + +S   P LL+ G  +G + I+++R   S  PV    +    H+ PV  ++W  QD
Sbjct: 311 VNVISWSRREPFLLSGG-DDGALKIWDLRQFKSGSPVATFKQ----HVAPVTSVEWHPQD 365

Query: 598 RGTTGDGKREILVSISADGRISKW 621
            G        +  +  AD +I++W
Sbjct: 366 SG--------VFAASGADHQITQW 381


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 64/287 (22%), Positives = 114/287 (39%), Gaps = 38/287 (13%)

Query: 573 PVLDSSESPQKHLGPVWQLQWIEQDRGTT----GDGKREILVSI------SADGRISKWV 622
           P LD+ +   K++G V +    E+++G T    G  K E           + DG +  W 
Sbjct: 141 PSLDNHQVSAKYIGSVEEA---EKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWA 197

Query: 623 IRKGLDCYDLMR--------LKRTTAASNKKGGEKEKK--DEALISR-----QAPGMCFA 667
             K +D  D+ +        L   TA   KKG ++E+K  +E  I          G  + 
Sbjct: 198 --KYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYL 255

Query: 668 FHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADW 727
             P+D  + L  T         C   ++ +  + GH   V  V   P    + LSCS D 
Sbjct: 256 HIPQDVGVNLRSTMPPE----KCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDC 311

Query: 728 GVIIWQQENVKPSL-SFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLHISTLDPLIV 786
            + +W+    +  L +F   +  V D+ ++   +   +AA +  +++WD           
Sbjct: 312 KIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFT 371

Query: 787 NTANP-GIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLETGR 832
           N   P  +KF       + +  + G SD ++  +++R+   V E  R
Sbjct: 372 NRKVPYCVKFNP--DEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDR 416


>gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
          Length = 480

 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 8/85 (9%)

Query: 702 GHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQ-------QENVKPSLSFYPATSVVYDVA 754
           GH+G V  + WNPF  ++  SCS D  V IW+       +   +  L  +  +  V  V 
Sbjct: 85  GHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRNMTEALLELHGHSRRVGLVE 144

Query: 755 WSPKSSYI-FAAANENRVEIWDLHI 778
           W P ++ I F+A  + +V IW+L +
Sbjct: 145 WHPTTNNILFSAGYDYKVLIWNLDV 169



 Score = 34.3 bits (77), Expect = 0.50
 Identities = 21/103 (20%), Positives = 48/103 (46%), Gaps = 4/103 (3%)

Query: 671 KDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVI 730
           +DT++ +    EG + +   +  E  L+ + GH   V  V W+P  +++  S   D+ V+
Sbjct: 108 EDTSVRIWEIPEGGLKR---NMTEALLELH-GHSRRVGLVEWHPTTNNILFSAGYDYKVL 163

Query: 731 IWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEI 773
           IW  +  +P       T V+  ++++   S +     + ++ +
Sbjct: 164 IWNLDVGEPVKMIDCHTDVILCMSFNTDGSLLTTTCKDKKLRV 206


>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
          Length = 308

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 26/60 (43%), Positives = 35/60 (58%), Gaps = 3/60 (5%)

Query: 701 RGHKGPVYKVTW-NPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPA--TSVVYDVAWSP 757
           RGH+GPV++V W +P   ++  SCS D  VIIW++EN     S   A   S V  V W+P
Sbjct: 40  RGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP 99



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 65/285 (22%), Positives = 99/285 (34%), Gaps = 85/285 (29%)

Query: 552 LAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQW------------------ 593
           LA    + ++ I++VR+   + + D     + H GPVWQ+ W                  
Sbjct: 14  LATCSSDRSVKIFDVRNGGQILIADL----RGHEGPVWQVAWAHPMYGNILASCSYDRKV 69

Query: 594 -IEQDRGTTGDGKRE--------------------ILVSISADGRIS--------KWVIR 624
            I ++   T +   E                    IL   S+DG IS        +W ++
Sbjct: 70  IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129

Query: 625 K-----GLDCYDLMRLKRTTAAS--NKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYL 677
           K      + C  +         S  +   G+K       I R A G C      D  I L
Sbjct: 130 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPN----YIKRFASGGC------DNLIKL 179

Query: 678 AGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCH---DVFLSCSADWGVIIWQQ 734
              EE    K      EQ L+    H   V  V W P          SCS D  V IW  
Sbjct: 180 WKEEEDGQWK-----EEQKLEA---HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 231

Query: 735 ENVK-----PSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIW 774
           ++       P L  +    VV+ V+WS  ++ +  +  +N+V +W
Sbjct: 232 DDASSNTWSPKL-LHKFNDVVWHVSWSITANILAVSGGDNKVTLW 275


>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
          Length = 322

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 26/60 (43%), Positives = 35/60 (58%), Gaps = 3/60 (5%)

Query: 701 RGHKGPVYKVTW-NPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPA--TSVVYDVAWSP 757
           RGH+GPV++V W +P   ++  SCS D  VIIW++EN     S   A   S V  V W+P
Sbjct: 54  RGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAP 113



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 65/285 (22%), Positives = 99/285 (34%), Gaps = 85/285 (29%)

Query: 552 LAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQW------------------ 593
           LA    + ++ I++VR+   + + D     + H GPVWQ+ W                  
Sbjct: 28  LATCSSDRSVKIFDVRNGGQILIADL----RGHEGPVWQVAWAHPMYGNILASCSYDRKV 83

Query: 594 -IEQDRGTTGDGKRE--------------------ILVSISADGRIS--------KWVIR 624
            I ++   T +   E                    IL   S+DG IS        +W ++
Sbjct: 84  IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143

Query: 625 K-----GLDCYDLMRLKRTTAAS--NKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYL 677
           K      + C  +         S  +   G+K       I R A G C      D  I L
Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPN----YIKRFASGGC------DNLIKL 193

Query: 678 AGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCH---DVFLSCSADWGVIIWQQ 734
              EE    K      EQ L+    H   V  V W P          SCS D  V IW  
Sbjct: 194 WKEEEDGQWK-----EEQKLEA---HSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTC 245

Query: 735 ENVK-----PSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIW 774
           ++       P L  +    VV+ V+WS  ++ +  +  +N+V +W
Sbjct: 246 DDASSNTWSPKL-LHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289


>gi|21536485 HIR histone cell cycle regulation defective homolog A
           [Homo sapiens]
          Length = 1017

 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 4/76 (5%)

Query: 701 RGHKGPVYKVTWNPFCHDVFL-SCSADWGVIIWQQENVKPSLSFYPATS-VVYDVAWSPK 758
           R H G V  V W+P  HD +L SCS D  V+IW        L+     S +V  + W P 
Sbjct: 128 RNHSGDVMDVAWSP--HDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPV 185

Query: 759 SSYIFAAANENRVEIW 774
             YI + A++  +++W
Sbjct: 186 GKYIASQADDRSLKVW 201



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 9/78 (11%)

Query: 695 QYLDTYRGHKGPVYKVTWNPFCHDVFLSCSAD------WGVIIWQQE-NVKPSLSFYPAT 747
           + L T RGH G V  +TW+P     +++  AD      W  + WQ E ++         T
Sbjct: 165 EILATLRGHSGLVKGLTWDPV--GKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGT 222

Query: 748 SVVYDVAWSPKSSYIFAA 765
           + V  ++WSP   Y+ +A
Sbjct: 223 THVLRLSWSPDGHYLVSA 240


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 9/139 (6%)

Query: 701 RGHKGPVYKVTWNPFCHDVFLSCSADWGVIIW-------QQENVKPSLSFYPATSVVYDV 753
           RGH+   Y ++WNP      LS S D  + +W       + + V     F   T+VV DV
Sbjct: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198

Query: 754 AWSPKSSYIF-AAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLL-VGD 811
           +W      +F + A++ ++ IWD   +       +      +   + F   ++ +L  G 
Sbjct: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258

Query: 812 SDGQVSVYELRNMPTVLET 830
           +D  V++++LRN+   L +
Sbjct: 259 ADKTVALWDLRNLKLKLHS 277



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 27/147 (18%), Positives = 59/147 (40%), Gaps = 15/147 (10%)

Query: 645 KGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHK 704
           +     K   ++ +  A   C +F+P    I   G+ +  +        +  L ++  HK
Sbjct: 223 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 282

Query: 705 GPVYKVTWNPFCHDVFLSCSADWGVIIW------------QQENVKPSLSFYPA--TSVV 750
             +++V W+P    +  S   D  + +W              E+  P L F     T+ +
Sbjct: 283 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 342

Query: 751 YDVAWSPKSSYIFAAANE-NRVEIWDL 776
            D +W+P   ++  + +E N +++W +
Sbjct: 343 SDFSWNPNEPWVICSVSEDNIMQVWQM 369



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 18/191 (9%)

Query: 604 GKREILVSISADGRISK--------WVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEA 655
           GK EI + I+ +G +++         +I       D++    T   S      +   D  
Sbjct: 78  GKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLR 137

Query: 656 LISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSY---NEQYLDT---YRGHKGPVYK 709
           L   Q  G   +++P  +   L+ +++  I     S      + +D    + GH   V  
Sbjct: 138 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 197

Query: 710 VTWNPFCHDVFLSCSADWGVIIW---QQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAA 766
           V+W+     +F S + D  ++IW        KPS S    T+ V  ++++P S +I A  
Sbjct: 198 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 257

Query: 767 NENR-VEIWDL 776
           + ++ V +WDL
Sbjct: 258 SADKTVALWDL 268


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 9/139 (6%)

Query: 701 RGHKGPVYKVTWNPFCHDVFLSCSADWGVIIW-------QQENVKPSLSFYPATSVVYDV 753
           RGH+   Y ++WNP      LS S D  + +W       + + V     F   T+VV DV
Sbjct: 173 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232

Query: 754 AWSPKSSYIF-AAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLL-VGD 811
           +W      +F + A++ ++ IWD   +       +      +   + F   ++ +L  G 
Sbjct: 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 812 SDGQVSVYELRNMPTVLET 830
           +D  V++++LRN+   L +
Sbjct: 293 ADKTVALWDLRNLKLKLHS 311



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 27/147 (18%), Positives = 59/147 (40%), Gaps = 15/147 (10%)

Query: 645 KGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHK 704
           +     K   ++ +  A   C +F+P    I   G+ +  +        +  L ++  HK
Sbjct: 257 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 316

Query: 705 GPVYKVTWNPFCHDVFLSCSADWGVIIW------------QQENVKPSLSFYPA--TSVV 750
             +++V W+P    +  S   D  + +W              E+  P L F     T+ +
Sbjct: 317 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 376

Query: 751 YDVAWSPKSSYIFAAANE-NRVEIWDL 776
            D +W+P   ++  + +E N +++W +
Sbjct: 377 SDFSWNPNEPWVICSVSEDNIMQVWQM 403



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 18/191 (9%)

Query: 604 GKREILVSISADGRISK--------WVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEA 655
           GK EI + I+ +G +++         +I       D++    T   S      +   D  
Sbjct: 112 GKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLR 171

Query: 656 LISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSY---NEQYLDT---YRGHKGPVYK 709
           L   Q  G   +++P  +   L+ +++  I     S      + +D    + GH   V  
Sbjct: 172 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 231

Query: 710 VTWNPFCHDVFLSCSADWGVIIW---QQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAA 766
           V+W+     +F S + D  ++IW        KPS S    T+ V  ++++P S +I A  
Sbjct: 232 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 291

Query: 767 NENR-VEIWDL 776
           + ++ V +WDL
Sbjct: 292 SADKTVALWDL 302


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 9/139 (6%)

Query: 701 RGHKGPVYKVTWNPFCHDVFLSCSADWGVIIW-------QQENVKPSLSFYPATSVVYDV 753
           RGH+   Y ++WNP      LS S D  + +W       + + V     F   T+VV DV
Sbjct: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233

Query: 754 AWSPKSSYIF-AAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLL-VGD 811
           +W      +F + A++ ++ IWD   +       +      +   + F   ++ +L  G 
Sbjct: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293

Query: 812 SDGQVSVYELRNMPTVLET 830
           +D  V++++LRN+   L +
Sbjct: 294 ADKTVALWDLRNLKLKLHS 312



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 27/147 (18%), Positives = 59/147 (40%), Gaps = 15/147 (10%)

Query: 645 KGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHK 704
           +     K   ++ +  A   C +F+P    I   G+ +  +        +  L ++  HK
Sbjct: 258 RSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHK 317

Query: 705 GPVYKVTWNPFCHDVFLSCSADWGVIIW------------QQENVKPSLSFYPA--TSVV 750
             +++V W+P    +  S   D  + +W              E+  P L F     T+ +
Sbjct: 318 DEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377

Query: 751 YDVAWSPKSSYIFAAANE-NRVEIWDL 776
            D +W+P   ++  + +E N +++W +
Sbjct: 378 SDFSWNPNEPWVICSVSEDNIMQVWQM 404



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 43/191 (22%), Positives = 80/191 (41%), Gaps = 18/191 (9%)

Query: 604 GKREILVSISADGRISK--------WVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEA 655
           GK EI + I+ +G +++         +I       D++    T   S      +   D  
Sbjct: 113 GKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLR 172

Query: 656 LISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSY---NEQYLDT---YRGHKGPVYK 709
           L   Q  G   +++P  +   L+ +++  I     S      + +D    + GH   V  
Sbjct: 173 LRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVED 232

Query: 710 VTWNPFCHDVFLSCSADWGVIIW---QQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAA 766
           V+W+     +F S + D  ++IW        KPS S    T+ V  ++++P S +I A  
Sbjct: 233 VSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG 292

Query: 767 NENR-VEIWDL 776
           + ++ V +WDL
Sbjct: 293 SADKTVALWDL 303


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 37/166 (22%), Positives = 71/166 (42%), Gaps = 6/166 (3%)

Query: 656 LISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPF 715
           L     P    +F P D N  L+ +E+G +   S       L  Y+GH  PV+   ++P+
Sbjct: 539 LYGHSGPVYGASFSP-DRNYLLSSSEDGTVRLWSLQ-TFTCLVGYKGHNYPVWDTQFSPY 596

Query: 716 CHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 775
            +  F+S   D    +W  ++ +P   F    + V    + P S+Y+   + +  V +WD
Sbjct: 597 GY-YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655

Query: 776 LHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYEL 821
           +       +      P     ++ F+     L  G +DG+V ++++
Sbjct: 656 VLNGNCVRIFTGHKGP---IHSLTFSPNGRFLATGATDGRVLLWDI 698



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 92/438 (21%), Positives = 158/438 (36%), Gaps = 99/438 (22%)

Query: 428 VLKEPEPEEP-EDVLESAKHEEVEEESKKEEEEEIHAEE-----STIPANLERLWSF--S 479
           +LKEPE E P +D  E  ++EE + + KK +++ I ++      +  P N   L     S
Sbjct: 376 LLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLPELKDS 435

Query: 480 CDLTKGLNVSSLAWN-KTNPDLLAVGYGHFGFKEQKRGLACCWSIKNPMWPERIYQSPYG 538
             L K +N+       +  PD L                 C ++  N       YQ   G
Sbjct: 436 DKLDKIMNMKETTKRVRLGPDCLPS--------------ICFYTFLNA------YQ---G 472

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNV--------RSNSNVPVLDSSESP--------- 581
           +TAVD +  + +L+A G+ + T+ +++V        +  S++ ++D              
Sbjct: 473 LTAVDVTDDS-SLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEK 531

Query: 582 --------QKHLGPVWQLQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLM 633
                     H GPV+         G +    R  L+S S DG +  W            
Sbjct: 532 TASELKILYGHSGPVY---------GASFSPDRNYLLSSSEDGTVRLW------------ 570

Query: 634 RLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYN 693
            L+  T     KG               P     F P     Y        + +   + +
Sbjct: 571 SLQTFTCLVGYKG------------HNYPVWDTQFSPY--GYYFVSGGHDRVARLWATDH 616

Query: 694 EQYLDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDV 753
            Q L  + GH   V    ++P  + V    SAD  V +W   N      F      ++ +
Sbjct: 617 YQPLRIFAGHLADVNCTRFHPNSNYVATG-SADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675

Query: 754 AWSPKSSYIFAAANENRVEIWDL-HISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDS 812
            +SP   ++   A + RV +WD+ H   +  L  +T        ++ F++  + L  G  
Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDT----VCSLRFSRDGEILASGSM 731

Query: 813 DGQVSVYELRNMPTVLET 830
           D  V +++       LET
Sbjct: 732 DNTVRLWDAIKAFEDLET 749


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 7/135 (5%)

Query: 691 SYNEQY-LDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSV 749
           S++  Y L  Y GH   V  V ++P  +    + S D  V +W  +       F      
Sbjct: 412 SFDRTYPLRIYAGHLADVDCVKFHPNSN-YLATGSTDKTVRLWSAQQGNSVRLFTGHRGP 470

Query: 750 VYDVAWSPKSSYIFAAANENRVEIWDLHISTL-DPLIVNTANPGIKFTTILFAKQTDCLL 808
           V  +A+SP   Y+ +A  + R+++WDL   TL   L  +T N     T++ F+  +  + 
Sbjct: 471 VLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN----ITSLTFSPDSGLIA 526

Query: 809 VGDSDGQVSVYELRN 823
               D  V V+++RN
Sbjct: 527 SASMDNSVRVWDIRN 541



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 701 RGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSS 760
           RGH GPVY   +      + LSCS D  +  W   +   ++ +      V+D+  SP S 
Sbjct: 339 RGHCGPVYSTRFLADSSGL-LSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397

Query: 761 YIFAAANENRVEIW 774
           Y  + +++    +W
Sbjct: 398 YFASGSHDRTARLW 411



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 19/75 (25%), Positives = 34/75 (45%), Gaps = 1/75 (1%)

Query: 700 YRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKS 759
           Y+GH  PV+ +  +P+    F S S D    +W  +   P   +    + V  V + P S
Sbjct: 380 YQGHAYPVWDLDISPYSL-YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNS 438

Query: 760 SYIFAAANENRVEIW 774
           +Y+   + +  V +W
Sbjct: 439 NYLATGSTDKTVRLW 453


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 36/139 (25%), Positives = 62/139 (44%), Gaps = 9/139 (6%)

Query: 701 RGHKGPVYKVTWNPFCHDVFLSCSADWGVIIW-------QQENVKPSLSFYPATSVVYDV 753
           RGH+   Y ++WN       LS S D  V +W       + + V     F   ++VV DV
Sbjct: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDV 232

Query: 754 AWSPKSSYIF-AAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLL-VGD 811
           AW      +F + A++ ++ IWD   +T             +   + F   ++ +L  G 
Sbjct: 233 AWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 812 SDGQVSVYELRNMPTVLET 830
           +D  V++++LRN+   L T
Sbjct: 293 ADKTVALWDLRNLKLKLHT 311



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 27/127 (21%), Positives = 53/127 (41%), Gaps = 15/127 (11%)

Query: 665 CFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHDVFLSCS 724
           C +F+P    I   G+ +  +        +  L T+  HK  +++V W+P    +  S  
Sbjct: 277 CLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSG 336

Query: 725 ADWGVIIW------------QQENVKPSLSFYPA--TSVVYDVAWSPKSSYIFAAANE-N 769
            D  + +W              E+  P L F     T+ + D +W+P   ++  + +E N
Sbjct: 337 TDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDN 396

Query: 770 RVEIWDL 776
            ++IW +
Sbjct: 397 IMQIWQM 403



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 23/81 (28%), Positives = 40/81 (49%), Gaps = 4/81 (4%)

Query: 700 YRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQEN---VKPSLSFYPATSVVYDVAWS 756
           + GH   V  V W+     +F S + D  ++IW   +    KPS      T+ V  ++++
Sbjct: 222 FTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFN 281

Query: 757 PKSSYIFAAANENR-VEIWDL 776
           P S +I A  + ++ V +WDL
Sbjct: 282 PYSEFILATGSADKTVALWDL 302


>gi|8922301 WD repeat domain 70 [Homo sapiens]
          Length = 654

 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 35/154 (22%), Positives = 64/154 (41%), Gaps = 10/154 (6%)

Query: 690 CSYNEQYL---DTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLS-FYP 745
           C   +QY+      +GH   ++  +W+P     F++CS D  V  W+ EN K   S F P
Sbjct: 266 CIKGDQYIVDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRTWEVENPKKQKSVFKP 325

Query: 746 ATS-----VVYDVAWSPKSSYIFAAANENRVEIWDLHISTLDPLIVNTA-NPGIKFTTIL 799
            T      +     +S   + I AA     ++IWD +++         A + G   + + 
Sbjct: 326 RTMQGKKVIPTTCTYSRDGNLIAAACQNGSIQIWDRNLTVHPKFHYKQAHDSGTDTSCVT 385

Query: 800 FAKQTDCLLVGDSDGQVSVYELRNMPTVLETGRG 833
           F+   + L     D  + ++++R     L +  G
Sbjct: 386 FSYDGNVLASRGGDDSLKLWDIRQFNKPLFSASG 419


>gi|13129110 WD repeat domain 77 [Homo sapiens]
          Length = 342

 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 10/79 (12%)

Query: 697 LDTYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKP------SLSFYPATSVV 750
           L +YR H   V  V  +P    VFLSCS D  +++W     KP      S   Y  TS  
Sbjct: 160 LSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTS-- 217

Query: 751 YDVAWSPKSSYIFAAANEN 769
             +AW P+ S +F   +EN
Sbjct: 218 --LAWHPQQSEVFVFGDEN 234



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 29/112 (25%), Positives = 53/112 (47%), Gaps = 3/112 (2%)

Query: 721 LSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANE-NRVEIWDLHIS 779
           +S S D  + +W         S+    + V  VA SP    +F + +E NR+ +WD    
Sbjct: 141 VSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCP 200

Query: 780 TLDPLIVNTANPGIKFTTILF-AKQTDCLLVGDSDGQVSVYELRNMPTVLET 830
                I  +A PG   T++ +  +Q++  + GD +G VS+ + ++   VL +
Sbjct: 201 KPASQIGCSA-PGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSS 251


>gi|45238858 WD repeat domain 44 protein [Homo sapiens]
          Length = 913

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 47/244 (19%), Positives = 96/244 (39%), Gaps = 30/244 (12%)

Query: 583 KHLGPVWQLQWIEQDRGTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAAS 642
           +H+G VW +++    R         +L S   D  +  W ++   D ++ MR+K  T   
Sbjct: 509 EHMGAVWTMKFSHCGR---------LLASAGQDNVVRIWALKNAFDYFNNMRMKYNTEGR 559

Query: 643 NKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRG 702
                 +E    +  S    G+C            +GT+E    K +  + ++    Y+G
Sbjct: 560 VSPSPSQESLSSSK-SDTDTGVC------------SGTDEDPDDK-NAPFRQRPFCKYKG 605

Query: 703 HKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSS-Y 761
           H   +  ++W+   +   LS S D  V +W     +  L  +     V  +A+ P+   Y
Sbjct: 606 HTADLLDLSWSK--NYFLLSSSMDKTVRLWHISR-RECLCCFQHIDFVTAIAFHPRDDRY 662

Query: 762 IFAAANENRVEIWDLHISTLDPLIVNTANPGIKFTTIL-FAKQTDCLLVGDSDGQVSVYE 820
             + + + ++ +W  +I      + N  +   K  T   F +     ++G  DG+   Y+
Sbjct: 663 FLSGSLDGKLRLW--NIPDKKVALWNEVDGQTKLITAANFCQNGKYAVIGTYDGRCIFYD 720

Query: 821 LRNM 824
             ++
Sbjct: 721 TEHL 724


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 51/249 (20%), Positives = 106/249 (42%), Gaps = 58/249 (23%)

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDR 598
           VT++D++     LLA G ++G   I+    N        + +  +H GP++ L+W ++  
Sbjct: 228 VTSLDWN-SEGTLLATGSYDGFARIWTKDGNL-------ASTLGQHKGPIFALKWNKK-- 277

Query: 599 GTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALIS 658
                                 +++  G+D        +TT   +   GE +++      
Sbjct: 278 --------------------GNFILSAGVD--------KTTIIWDAHTGEAKQQ---FPF 306

Query: 659 RQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHD 718
             AP +   +  +  N + + + +  IH C     ++ + T++GH   V  + W+P   +
Sbjct: 307 HSAPALDVDW--QSNNTFASCSTDMCIHVCKLG-QDRPIKTFQGHTNEVNAIKWDP-TGN 362

Query: 719 VFLSCSADWGVIIW--QQENVKPSLSFYPATSVVYDVAWS--------PKSSYIFAAAN- 767
           +  SCS D  + IW  +Q+N    L  +     +Y + WS        P ++ + A+A+ 
Sbjct: 363 LLASCSDDMTLKIWSMKQDNCVHDLQAH--NKEIYTIKWSPTGPGTNNPNANLMLASASF 420

Query: 768 ENRVEIWDL 776
           ++ V +WD+
Sbjct: 421 DSTVRLWDV 429



 Score = 37.0 bits (84), Expect = 0.077
 Identities = 40/167 (23%), Positives = 65/167 (38%), Gaps = 39/167 (23%)

Query: 550 NLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDRGTTGDGKREIL 609
           NLLA    + T+ I++++ ++ V  L      Q H   ++ ++W     GT       +L
Sbjct: 362 NLLASCSDDMTLKIWSMKQDNCVHDL------QAHNKEIYTIKWSPTGPGTNNPNANLML 415

Query: 610 VSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFH 669
            S S D  +  W + +G+  + L +                         Q P    AF 
Sbjct: 416 ASASFDSTVRLWDVDRGICIHTLTK------------------------HQEPVYSVAFS 451

Query: 670 PKDTNIYLAGTEEGHIHKCSCSYNEQ---YLDTYRGHKGPVYKVTWN 713
           P     YLA    G   KC   +N Q    + +YRG  G +++V WN
Sbjct: 452 PDGR--YLA---SGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWN 492



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 30/130 (23%), Positives = 50/130 (38%), Gaps = 12/130 (9%)

Query: 701 RGHKGPVYKVTW--------NPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYD 752
           + H   +Y + W        NP  + +  S S D  V +W  +      +       VY 
Sbjct: 388 QAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYS 447

Query: 753 VAWSPKSSYIFAAANENRVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDS 812
           VA+SP   Y+ + + +  V IW+     L    V++         + +    D +    S
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGAL----VHSYRGTGGIFEVCWNAAGDKVGASAS 503

Query: 813 DGQVSVYELR 822
           DG V V +LR
Sbjct: 504 DGSVCVLDLR 513


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/318 (19%), Positives = 124/318 (38%), Gaps = 58/318 (18%)

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDR 598
           VT++D++     LLA+G ++G   I+    N        + +  +H GP++ L+W ++  
Sbjct: 238 VTSLDWNSDG-TLLAMGSYDGFARIWTENGNL-------ASTLGQHKGPIFALKWNKK-- 287

Query: 599 GTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALIS 658
                                 +V+  G+D        +TT   +   GE +++      
Sbjct: 288 --------------------GNYVLSAGVD--------KTTIIWDAHTGEAKQQ---FPF 316

Query: 659 RQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHD 718
             AP +   +    T  + + + +  IH C    +   + T++GH   V  + W+P    
Sbjct: 317 HSAPALDVDWQNNMT--FASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGM 372

Query: 719 VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS--------PKSSYIFAAAN-EN 769
           +  SCS D  + IW  +           +  +Y + WS        P SS + A+A+ ++
Sbjct: 373 LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDS 432

Query: 770 RVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLE 829
            V +WD+        ++    P     ++ F+     L  G  D  V ++  ++   V  
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEP---VYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 830 -TGRGDIMDTLLGSKSNQ 846
             G G I +    ++ ++
Sbjct: 490 YQGTGGIFEVCWNARGDK 507


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/318 (19%), Positives = 124/318 (38%), Gaps = 58/318 (18%)

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDR 598
           VT++D++     LLA+G ++G   I+    N        + +  +H GP++ L+W ++  
Sbjct: 238 VTSLDWNSDG-TLLAMGSYDGFARIWTENGNL-------ASTLGQHKGPIFALKWNKK-- 287

Query: 599 GTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALIS 658
                                 +V+  G+D        +TT   +   GE +++      
Sbjct: 288 --------------------GNYVLSAGVD--------KTTIIWDAHTGEAKQQ---FPF 316

Query: 659 RQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHD 718
             AP +   +    T  + + + +  IH C    +   + T++GH   V  + W+P    
Sbjct: 317 HSAPALDVDWQNNMT--FASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGM 372

Query: 719 VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS--------PKSSYIFAAAN-EN 769
           +  SCS D  + IW  +           +  +Y + WS        P SS + A+A+ ++
Sbjct: 373 LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDS 432

Query: 770 RVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLE 829
            V +WD+        ++    P     ++ F+     L  G  D  V ++  ++   V  
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEP---VYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 830 -TGRGDIMDTLLGSKSNQ 846
             G G I +    ++ ++
Sbjct: 490 YQGTGGIFEVCWNARGDK 507


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 61/318 (19%), Positives = 124/318 (38%), Gaps = 58/318 (18%)

Query: 539 VTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQDR 598
           VT++D++     LLA+G ++G   I+    N        + +  +H GP++ L+W ++  
Sbjct: 238 VTSLDWNSDG-TLLAMGSYDGFARIWTENGNL-------ASTLGQHKGPIFALKWNKK-- 287

Query: 599 GTTGDGKREILVSISADGRISKWVIRKGLDCYDLMRLKRTTAASNKKGGEKEKKDEALIS 658
                                 +V+  G+D        +TT   +   GE +++      
Sbjct: 288 --------------------GNYVLSAGVD--------KTTIIWDAHTGEAKQQ---FPF 316

Query: 659 RQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLDTYRGHKGPVYKVTWNPFCHD 718
             AP +   +    T  + + + +  IH C    +   + T++GH   V  + W+P    
Sbjct: 317 HSAPALDVDWQNNMT--FASCSTDMCIHVCRLGCDHP-VKTFQGHTNEVNAIKWDP-SGM 372

Query: 719 VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS--------PKSSYIFAAAN-EN 769
           +  SCS D  + IW  +           +  +Y + WS        P SS + A+A+ ++
Sbjct: 373 LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDS 432

Query: 770 RVEIWDLHISTLDPLIVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRNMPTVLE 829
            V +WD+        ++    P     ++ F+     L  G  D  V ++  ++   V  
Sbjct: 433 TVRLWDVEQGVCTHTLMKHQEP---VYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHS 489

Query: 830 -TGRGDIMDTLLGSKSNQ 846
             G G I +    ++ ++
Sbjct: 490 YQGTGGIFEVCWNARGDK 507


>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
           [Homo sapiens]
          Length = 1006

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 34/107 (31%), Positives = 46/107 (42%), Gaps = 18/107 (16%)

Query: 699 TYRGHKGPVYKVTWNPFCHDVFL-SCSADWGVIIWQQENVKPSLSFYPATSVVYDV---- 753
           T+RGH  PV  ++++P   D+FL S S D  V +WQ  +   ++S +P      DV    
Sbjct: 8   TFRGHDAPVLSLSFDP--KDIFLASASCDGSVRVWQISDQTCAIS-WPLLQKCNDVINAK 64

Query: 754 -----AWSPKSSYIFAAANENRV-----EIWDLHISTLDPLIVNTAN 790
                AW PKS  + A   E  V     E W       D  I  T N
Sbjct: 65  SICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLN 111


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.382 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,202,527
Number of Sequences: 37866
Number of extensions: 1578717
Number of successful extensions: 10494
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 238
Number of HSP's that attempted gapping in prelim test: 7827
Number of HSP's gapped (non-prelim): 2047
length of query: 848
length of database: 18,247,518
effective HSP length: 111
effective length of query: 737
effective length of database: 14,044,392
effective search space: 10350716904
effective search space used: 10350716904
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.