Search of human proteins with 109150416

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|109150416 peroxidasin [Homo sapiens]
         (1479 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|109150416 peroxidasin [Homo sapiens]                              3034   0.0  
gi|126517478 peroxidasin homolog-like [Homo sapiens]                 1819   0.0  
gi|28558982 thyroid peroxidase isoform a [Homo sapiens]               539   e-153
gi|28558988 thyroid peroxidase isoform d [Homo sapiens]               539   e-153
gi|4503595 eosinophil peroxidase [Homo sapiens]                       517   e-146
gi|4557759 myeloperoxidase [Homo sapiens]                             510   e-144
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]    451   e-126
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]   449   e-126
gi|28558984 thyroid peroxidase isoform b [Homo sapiens]               443   e-124
gi|28558990 thyroid peroxidase isoform e [Homo sapiens]               256   9e-68
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...   226   2e-58
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...   222   2e-57
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...   222   2e-57
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     206   2e-52
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   206   2e-52
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   206   2e-52
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      206   2e-52
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...   204   5e-52
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    201   6e-51
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    201   6e-51
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   201   6e-51
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   201   6e-51
gi|118572606 hemicentin 1 [Homo sapiens]                              199   1e-50
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   199   1e-50
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        195   3e-49
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   188   4e-47
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   188   4e-47
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   188   4e-47
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           176   2e-43
gi|139948432 adlican [Homo sapiens]                                   171   4e-42

>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 3034 bits (7866), Expect = 0.0
 Identities = 1479/1479 (100%), Positives = 1479/1479 (100%)

Query: 1    MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV 60
            MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV
Sbjct: 1    MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV 60

Query: 61   APQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN 120
            APQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN
Sbjct: 61   APQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN 120

Query: 121  EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH 180
            EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH
Sbjct: 121  EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH 180

Query: 181  LESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE 240
            LESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE
Sbjct: 181  LESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE 240

Query: 241  LNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG 300
            LNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG
Sbjct: 241  LNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG 300

Query: 301  TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
            TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT
Sbjct: 301  TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360

Query: 361  LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420
            LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS
Sbjct: 361  LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420

Query: 421  VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480
            VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL
Sbjct: 421  VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480

Query: 481  VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA 540
            VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA
Sbjct: 481  VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGA 540

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI 600
            NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI
Sbjct: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI 600

Query: 601  GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLAL 660
            GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLAL
Sbjct: 601  GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLAL 660

Query: 661  FRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL 720
            FRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL
Sbjct: 661  FRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANL 720

Query: 721  SGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRG 780
            SGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRG
Sbjct: 721  SGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRG 780

Query: 781  INPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR 840
            INPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR
Sbjct: 781  INPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQAR 840

Query: 841  FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPR 900
            FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPR
Sbjct: 841  FSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPR 900

Query: 901  EQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECM 960
            EQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECM
Sbjct: 901  EQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECM 960

Query: 961  RDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRK 1020
            RDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRK
Sbjct: 961  RDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRK 1020

Query: 1021 IVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPL 1080
            IVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPL
Sbjct: 1021 IVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPL 1080

Query: 1081 LYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELT 1140
            LYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELT
Sbjct: 1081 LYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELT 1140

Query: 1141 ERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREK 1200
            ERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREK
Sbjct: 1141 ERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREK 1200

Query: 1201 LKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA 1260
            LKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA
Sbjct: 1201 LKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPA 1260

Query: 1261 QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCR 1320
            QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCR
Sbjct: 1261 QLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCR 1320

Query: 1321 TRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS 1380
            TRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS
Sbjct: 1321 TRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDAS 1380

Query: 1381 GTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECK 1440
            GTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECK
Sbjct: 1381 GTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECK 1440

Query: 1441 DGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP 1479
            DGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP
Sbjct: 1441 DGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP 1479


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 1819 bits (4711), Expect = 0.0
 Identities = 888/1458 (60%), Positives = 1090/1458 (74%), Gaps = 17/1458 (1%)

Query: 18   LFCAWGTLAVVAQ--KPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIR 75
            LFC W TL ++A    PG  CPSRCLCF++TVRCMHL+L+ +P V  QT++LDLRFNRIR
Sbjct: 5    LFC-WTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIR 63

Query: 76   EIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLAS 135
            EI   AF++L+NLNTLLLNNN I++I   AFE LENL YLYLYKNEI ++D+Q FKGL S
Sbjct: 64   EIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLIS 123

Query: 136  LEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLH 195
            LE LY+HFNQ+E L P++F  L +LERLFLHNN+++ +  G+F++L+S+KRLRLDSN L 
Sbjct: 124  LEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALV 183

Query: 196  CDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDA 255
            CDC+++WL +LL+ +A+ G+ QAAA CEYPRR+ GR+VA++T EE NC+ PRIT EPQD 
Sbjct: 184  CDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDV 243

Query: 256  DVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIY 315
            +V SGNTVYFTCRAEGNPKPEIIW+ NN+ L ++ D+RLN+ DDGTLMI+NT+E+DQG+Y
Sbjct: 244  EVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVY 303

Query: 316  QCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISW 375
            QCMA+N AGE KTQ   LRY   PA+P+FVIQPQ+TEVL+G S TLEC ATGHP P I+W
Sbjct: 304  QCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITW 363

Query: 376  TRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF 435
            TR +   L +D   ++  S GLY+QN+ Q D G + C A N+  +V A A IIVQA PQF
Sbjct: 364  TRDNG--LELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQF 421

Query: 436  TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALH 495
            TVTP+D+VV+E   V++ CEA GNPPPVI WTK G QL V+ +H VLSSGTLRI   A H
Sbjct: 422  TVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQH 481

Query: 496  DQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555
            DQGQYECQAV+ +G +KV   LTV+P+   VF  +P DT+VEVG N+ + C +QGEP+P 
Sbjct: 482  DQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPI 541

Query: 556  ITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPD 615
            ITWNK+GVQ+TESGKFH+  EG LTI D G  D GRYECVARN+ G A  +M L+V    
Sbjct: 542  ITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQ 601

Query: 616  VSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARA 675
              + GD FV +SI++A+  VD AINSTR HLF  +P + +DLLA F YPRDP  VE ARA
Sbjct: 602  GRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARA 661

Query: 676  GEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDM 735
            GEIFE TLQLI+E V+ GL VDL G  + YNDLVSP+ L+LIANLSGCTA R + NCS+ 
Sbjct: 662  GEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNR 721

Query: 736  CFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMP 795
            CFH KYR HDGTCNNLQ P WGA+LTAF RLL+  Y +G   PRG+    + +   LP P
Sbjct: 722  CFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLP-VGSRQPLPPP 780

Query: 796  RLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDP 855
            RLV+T       VTPD  +T MLM WG FL+HDLD TV ALS ARFSDG+ CS+VC+NDP
Sbjct: 781  RLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDP 840

Query: 856  PCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNV 915
            PCF +     D R  + A CM F RSSP C SG  S  ++SVY REQINQ T+YID SNV
Sbjct: 841  PCFPMNTRHADPRG-THAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNV 899

Query: 916  YGSTEHEARSIRDLASHRGLLRQGIV-QRSGKPLLPFATGPPTECMRDENESPIPCFLAG 974
            YGS+E E++++RD +  RGLL+ G     SGKPLLPF+TGPPTEC R E ESP  CFLAG
Sbjct: 900  YGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESP--CFLAG 957

Query: 975  DHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHW 1034
            DHRANE L L +MHTLWFREHNR+ATEL  LNPHW+G+T+Y E RKIVGAE+QHITY HW
Sbjct: 958  DHRANEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHW 1017

Query: 1035 LPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD 1094
            LPK+LG+ G R L  Y GY+P +NAGI N+FATAAFRFGHTL+NP+LYRL+     I++ 
Sbjct: 1018 LPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEG 1077

Query: 1095 HLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDL 1154
            HLP HKA FSP RI+ EGGIDP+LRGLFGVA K R PS LL+ ELT+RLFS A++ A+D 
Sbjct: 1078 HLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDS 1137

Query: 1155 AAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLF 1214
            AA  IQRGRDHGIPPY D+RV+CNL++   FEDL+NEIK+ EIR+KL++LYGS  +IDL+
Sbjct: 1138 AATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLW 1197

Query: 1215 PALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARIL 1274
            PAL+VEDL+PG+R+GPTLMCL  TQF+RLRDGDR WYENPGVF+PAQLTQ+KQ SL+R+L
Sbjct: 1198 PALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVL 1257

Query: 1275 CDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRG 1334
            CDN D+I +VQ+DVF  AE+P  Y +C EIP+VDLRVWQDCC DCR+RGQF A +   + 
Sbjct: 1258 CDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQK 1317

Query: 1335 RRSLEFSYQEDKPTKKT--RPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEM 1392
            +RS ++SY  DK  + +  R R+   +   GE   N T    T+     + DF  F  E+
Sbjct: 1318 KRSAQYSYPVDKDMELSHLRSRQQDKI-YVGEDARNVTVLAKTKF----SQDFSTFAAEI 1372

Query: 1393 QKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACP 1452
            Q+TIT LR QI KLE+RL    C D  G       +W K+ CT C C+ GQVTC VE CP
Sbjct: 1373 QETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICP 1432

Query: 1453 PATCAVPVNIPGACCPVC 1470
            PA C  P  + G CCPVC
Sbjct: 1433 PAPCPSPELVKGTCCPVC 1450


>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
          Length = 933

 Score =  539 bits (1388), Expect = e-153
 Identities = 298/706 (42%), Positives = 420/706 (59%), Gaps = 25/706 (3%)

Query: 624  VATSIVEAIATVDRAINSTRTHLFDSRP-RSPNDLLALFRYPRDPYTVEQARAGEIFERT 682
            V++ + E+   VD A+ +T       R   SP  LL+  + P +P +   ARA EI E +
Sbjct: 39   VSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLP-EPTSGVIARAAEIMETS 97

Query: 683  LQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYR 742
            +Q ++  V           S H  D +S   L++IAN+SGC  +     C + C   KYR
Sbjct: 98   IQAMKRKVNLKTQ-----QSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 152

Query: 743  THDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTL 802
               G CNN  HP WGAS TA  R L  VYE+GF+ PRG NP  LYNG  LP  R V+  +
Sbjct: 153  PITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHV 212

Query: 803  I--GTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSV 860
            I    E VT D++++ +LM WGQ++DHD+  T  + S+A F  G  C   C N  PCF +
Sbjct: 213  IQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272

Query: 861  MIPPNDSRARSGARCMFFVRSSPVCGSGMTSLL---MNSVYPREQINQLTSYIDASNVYG 917
             +P  ++R  +G  C+ F RSS  CG+G    L   +++  PR+Q+N LTS++DAS VYG
Sbjct: 273  QLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331

Query: 918  STEHEARSIRDLASHRGLLR-QGIVQRSGKPLLPFATG-PPTECMRDEN---ESPIPCFL 972
            S+    R +R+  S  GLLR    ++ SG+  LPF     P  C  +     E+  PCFL
Sbjct: 332  SSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFL 391

Query: 973  AGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQ 1032
            AGD RA+E   LT++HTLW REHNR+A  L  LN HW  D +Y E RK+VGA  Q IT +
Sbjct: 392  AGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLR 451

Query: 1033 HWLPKILG-EVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPI 1091
             ++P+ILG E   + +G Y GYD   N  + N F+TAAFRFGH  ++PL+ RLD +FQ  
Sbjct: 452  DYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE- 510

Query: 1092 AQDHLP---LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAH 1148
                LP   LH+AFFSP+ ++  GG+DPL+RGL     K++V  QL+N ELTERLF +++
Sbjct: 511  -HPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSN 569

Query: 1149 TVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGST 1208
            +  LDLA+IN+QRGRDHG+P Y+++R +C L    T  DL   I +  + +K+  LY   
Sbjct: 570  SSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHP 629

Query: 1209 LNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQT 1268
             NID++   + E+ +P +R GP   CL+  Q K LRDGD  W+EN  VF+ AQ  ++++ 
Sbjct: 630  DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH 689

Query: 1269 SLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
            SL+R++CDN   +TRV  D F+V +FP  + SCD I  ++L  W++
Sbjct: 690  SLSRVICDNT-GLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734


>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
          Length = 889

 Score =  539 bits (1388), Expect = e-153
 Identities = 298/706 (42%), Positives = 420/706 (59%), Gaps = 25/706 (3%)

Query: 624  VATSIVEAIATVDRAINSTRTHLFDSRP-RSPNDLLALFRYPRDPYTVEQARAGEIFERT 682
            V++ + E+   VD A+ +T       R   SP  LL+  + P +P +   ARA EI E +
Sbjct: 39   VSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLP-EPTSGVIARAAEIMETS 97

Query: 683  LQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYR 742
            +Q ++  V           S H  D +S   L++IAN+SGC  +     C + C   KYR
Sbjct: 98   IQAMKRKVNLKTQ-----QSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 152

Query: 743  THDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTL 802
               G CNN  HP WGAS TA  R L  VYE+GF+ PRG NP  LYNG  LP  R V+  +
Sbjct: 153  PITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHV 212

Query: 803  I--GTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSV 860
            I    E VT D++++ +LM WGQ++DHD+  T  + S+A F  G  C   C N  PCF +
Sbjct: 213  IQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272

Query: 861  MIPPNDSRARSGARCMFFVRSSPVCGSGMTSLL---MNSVYPREQINQLTSYIDASNVYG 917
             +P  ++R  +G  C+ F RSS  CG+G    L   +++  PR+Q+N LTS++DAS VYG
Sbjct: 273  QLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331

Query: 918  STEHEARSIRDLASHRGLLR-QGIVQRSGKPLLPFATG-PPTECMRDEN---ESPIPCFL 972
            S+    R +R+  S  GLLR    ++ SG+  LPF     P  C  +     E+  PCFL
Sbjct: 332  SSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFL 391

Query: 973  AGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQ 1032
            AGD RA+E   LT++HTLW REHNR+A  L  LN HW  D +Y E RK+VGA  Q IT +
Sbjct: 392  AGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLR 451

Query: 1033 HWLPKILG-EVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPI 1091
             ++P+ILG E   + +G Y GYD   N  + N F+TAAFRFGH  ++PL+ RLD +FQ  
Sbjct: 452  DYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE- 510

Query: 1092 AQDHLP---LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAH 1148
                LP   LH+AFFSP+ ++  GG+DPL+RGL     K++V  QL+N ELTERLF +++
Sbjct: 511  -HPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSN 569

Query: 1149 TVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGST 1208
            +  LDLA+IN+QRGRDHG+P Y+++R +C L    T  DL   I +  + +K+  LY   
Sbjct: 570  SSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHP 629

Query: 1209 LNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQT 1268
             NID++   + E+ +P +R GP   CL+  Q K LRDGD  W+EN  VF+ AQ  ++++ 
Sbjct: 630  DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH 689

Query: 1269 SLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
            SL+R++CDN   +TRV  D F+V +FP  + SCD I  ++L  W++
Sbjct: 690  SLSRVICDNT-GLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 734


>gi|4503595 eosinophil peroxidase [Homo sapiens]
          Length = 715

 Score =  517 bits (1331), Expect = e-146
 Identities = 288/694 (41%), Positives = 397/694 (57%), Gaps = 28/694 (4%)

Query: 628  IVEAIATVDRAINSTRTHL---FDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQ 684
            I EA   VD A N T+  +     S   SP DLL+ F+ P    T    RA +     L 
Sbjct: 40   IAEAKLLVDAAYNWTQKSIKQRLRSGSASPMDLLSYFKQPVAA-TRTVVRAADYMHVALG 98

Query: 685  LIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTH 744
            L++E +Q       N T     D+++   L L++  SGC    +   CSD     KYRT 
Sbjct: 99   LLEEKLQPQRSGPFNVT-----DVLTEPQLRLLSQASGCALRDQAERCSD-----KYRTI 148

Query: 745  DGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIG 804
             G CNN + P+ GAS  A  R L + YE+G + P G  P R  NG  LP+ R VS  ++ 
Sbjct: 149  TGRCNNKRRPLLGASNQALARWLPAEYEDGLSLPFGWTPSRRRNGFLLPLVRAVSNQIVR 208

Query: 805  --TETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMI 862
               E +T D     M MQWGQF+DHDLD +  + ++  F+ G  C   C+  PPCF + I
Sbjct: 209  FPNERLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFTAGVDCERTCAQLPPCFPIKI 268

Query: 863  PPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHE 922
            PPND R ++   C+ F RS+P C      +       R QIN LTS++DAS VYGS    
Sbjct: 269  PPNDPRIKNQRDCIPFFRSAPSCPQNKNRV-------RNQINALTSFVDASMVYGSEVSL 321

Query: 923  ARSIRDLASHRGLLR-QGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQ 981
            +  +R+  ++ GLL      Q +G+ LLPF       C+     + IPCFLAGD R+ E 
Sbjct: 322  SLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSTET 381

Query: 982  LGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGE 1041
              L +MHTL+ REHNR+ATEL +LNP W+GD +Y E RKI+GA +Q ITY+ +LP +LG+
Sbjct: 382  PKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEARKIMGAMVQIITYRDFLPLVLGK 441

Query: 1042 V-GMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD-HLPLH 1099
                RTLG Y GY   ++  + N F T AFRFGHT++ P ++RLD  ++  A + H+PL 
Sbjct: 442  ARARRTLGHYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLS 500

Query: 1100 KAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINI 1159
             AFF+ +RIV EGGIDP+LRGL     K+     +L  EL +RLF     + LDLAA+N+
Sbjct: 501  SAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVDELRDRLFRQVRRIGLDLAALNM 560

Query: 1160 QRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVV 1219
            QR RDHG+P Y+ +R +C LS       L   +KN ++  K   LYG+  NID++   + 
Sbjct: 561  QRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLNLYGTPDNIDIWIGAIA 620

Query: 1220 EDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNAD 1279
            E L+PG+R+GP L CL   QF+R RDGDR W++  GVF+  Q   + + SL+RI+CDN  
Sbjct: 621  EPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVFTKRQRKALSRISLSRIICDNT- 679

Query: 1280 NITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQ 1313
             IT V  D+FR   +P G+ +C  IPR++L  W+
Sbjct: 680  GITTVSRDIFRANIYPRGFVNCSRIPRLNLSAWR 713


>gi|4557759 myeloperoxidase [Homo sapiens]
          Length = 745

 Score =  510 bits (1313), Expect = e-144
 Identities = 296/750 (39%), Positives = 419/750 (55%), Gaps = 38/750 (5%)

Query: 583  DVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDP---------FVATSIVEAIA 633
            D+GP  AG      +  +  A +  +L+   P  S    P          V +S+ EA  
Sbjct: 14   DLGPCWAGGLTAEMKLLLALAGLLAILAT--PQPSEGAAPAVLGEVDTSLVLSSMEEAKQ 71

Query: 634  TVDRAINSTRTHL---FDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHV 690
             VD+A    R  +     S   SP +LL+ F+ P    T    RA +     L L++  +
Sbjct: 72   LVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAA-TRTAVRAADYLHVALDLLERKL 130

Query: 691  QHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNN 750
            +      L    ++  D+++P  LN+++  SGC        C +     KYRT  G CNN
Sbjct: 131  R-----SLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ---DKYRTITGMCNN 182

Query: 751  LQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIG--TETV 808
             + P  GAS  AF R L + YE+GF+ P G  P    NG  + + R VS  ++   T+ +
Sbjct: 183  RRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQL 242

Query: 809  TPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSR 868
            TPD++ + M MQWGQ LDHDLD T    ++A F  G +C   C   PPCF + IPPND R
Sbjct: 243  TPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPR 302

Query: 869  ARSGARCMFFVRSSPVC-GSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIR 927
             ++ A C+ F RS P C GS +T         R QIN LTS++DAS VYGS E  AR++R
Sbjct: 303  IKNQADCIPFFRSCPACPGSNITI--------RNQINALTSFVDASMVYGSEEPLARNLR 354

Query: 928  DLASHRGLLRQGI-VQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTS 986
            ++++  GLL      Q +G+ LLPF       C+     + IPCFLAGD R++E   LTS
Sbjct: 355  NMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTS 414

Query: 987  MHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRT 1046
            MHTL  REHNR+ATEL  LNP WDG+ +Y E RKIVGA +Q ITY+ +LP +LG   MR 
Sbjct: 415  MHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRK 474

Query: 1047 -LGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD-HLPLHKAFFS 1104
             L  Y  Y+  ++  I N F T AFR+GHTL+ P ++RLD  +QP+  +  +PL + FF+
Sbjct: 475  YLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFA 533

Query: 1105 PFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRD 1164
             +R+V EGGIDP+LRGL     K+   +Q+   E+ ERLF     + LDL A+N+QR RD
Sbjct: 534  SWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRD 593

Query: 1165 HGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVP 1224
            HG+P Y+ +R +C L    T   L   ++N ++  KL   YG+  NID++   V E L  
Sbjct: 594  HGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKR 653

Query: 1225 GSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNADNITRV 1284
              R+GP L C++ TQF++LRDGDR W+EN GVFS  Q   + Q SL RI+CDN    T  
Sbjct: 654  KGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVS 713

Query: 1285 QSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
            ++++F    +P  + +C  +P ++L  W++
Sbjct: 714  KNNIFMSNSYPRDFVNCSTLPALNLASWRE 743


>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
          Length = 712

 Score =  451 bits (1159), Expect = e-126
 Identities = 267/698 (38%), Positives = 389/698 (55%), Gaps = 33/698 (4%)

Query: 624  VATSIVEAIATVDRAINSTRTHL---FDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFE 680
            ++ ++ +A   V++A   +RT L     S   +   L    ++ +   T    R G+++E
Sbjct: 34   ISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGR-TRTAIRNGQVWE 92

Query: 681  RTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQK 740
             +L+ +++         L   +    DL S      ++   GC A   V  C D C    
Sbjct: 93   ESLKRLRQKAS------LTNVTDPSLDLTS------LSLEVGCGAPAPVVRC-DPC--SP 137

Query: 741  YRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVST 800
            YRT  G CNN + P  GA+  A  R L + YE+G + P G  P +  NG  LP+ R VS 
Sbjct: 138  YRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSN 197

Query: 801  TLIG--TETVTPDEQFTHMLMQWGQFLDHDLD-STVVALSQARFSDGQHCSNVCSNDPPC 857
             ++G   E    D+  + + MQWGQ +DHDLD +    L  + +S  Q C   C     C
Sbjct: 198  KIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQ-CDEYCIQGDNC 256

Query: 858  FSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYG 917
            F +M PPND +A +  +CM F R+  VC +     L      REQIN LTS++DAS VY 
Sbjct: 257  FPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLA-----REQINALTSFLDASFVYS 311

Query: 918  STEHEARSIRDLASHRGLLRQGI-VQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDH 976
            S    A  +R+L+S  GL+     V   G P LP+ +  P+ C      + +PCFLAGD 
Sbjct: 312  SEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVPCFLAGDS 371

Query: 977  RANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLP 1036
            RA+E + L + HTL+ REHNR+A EL +LNP WDG+ +Y E RKI+GA +Q IT++ +LP
Sbjct: 372  RASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLP 431

Query: 1037 KILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD-H 1095
             +LG+   + +  Y GY   ++  I N F T AFRFGH  V   ++RLDEN+QP   +  
Sbjct: 432  ILLGDHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENYQPWGPEPE 490

Query: 1096 LPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTV-ALDL 1154
            LPLH  FF+ +R+V +GGIDPL+RGL     K+   ++++  EL  +LF   H +   DL
Sbjct: 491  LPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDL 550

Query: 1155 AAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLF 1214
            AAIN QR RDHG P Y+ +R +C+LS   T E+L   +K+  + +KL  LYG+  NID++
Sbjct: 551  AAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIW 610

Query: 1215 PALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARIL 1274
               + E LV   R+GP L CLL  QF+++RDGDR W+ENPGVF+  Q   +++ S +R++
Sbjct: 611  IGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLV 670

Query: 1275 CDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVW 1312
            CDN   IT+V  D F    +P+ +  C  I ++DL  W
Sbjct: 671  CDNT-RITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 707


>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
          Length = 629

 Score =  449 bits (1155), Expect = e-126
 Identities = 250/597 (41%), Positives = 349/597 (58%), Gaps = 17/597 (2%)

Query: 722  GCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGI 781
            GC A   V  C D C    YRT  G CNN + P  GA+  A  R L + YE+G + P G 
Sbjct: 39   GCGAPAPVVRC-DPC--SPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGW 95

Query: 782  NPHRLYNGHALPMPRLVSTTLIG--TETVTPDEQFTHMLMQWGQFLDHDLD-STVVALSQ 838
             P +  NG  LP+ R VS  ++G   E    D+  + + MQWGQ +DHDLD +    L  
Sbjct: 96   TPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGS 155

Query: 839  ARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVY 898
            + +S  Q C   C     CF +M PPND +A +  +CM F R+  VC +     L     
Sbjct: 156  SEYSKAQ-CDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLA---- 210

Query: 899  PREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGI-VQRSGKPLLPFATGPPT 957
             REQIN LTS++DAS VY S    A  +R+L+S  GL+     V   G P LP+ +  P+
Sbjct: 211  -REQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPS 269

Query: 958  ECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYE 1017
             C      + +PCFLAGD RA+E + L + HTL+ REHNR+A EL +LNP WDG+ +Y E
Sbjct: 270  PCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQE 329

Query: 1018 TRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLV 1077
             RKI+GA +Q IT++ +LP +LG+   + +  Y GY   ++  I N F T AFRFGH  V
Sbjct: 330  ARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVF-TFAFRFGHLEV 388

Query: 1078 NPLLYRLDENFQPIAQD-HLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLN 1136
               ++RLDEN+QP   +  LPLH  FF+ +R+V +GGIDPL+RGL     K+   ++++ 
Sbjct: 389  PSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMT 448

Query: 1137 TELTERLFSMAHTV-ALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNP 1195
             EL  +LF   H +   DLAAIN QR RDHG P Y+ +R +C+LS   T E+L   +K+ 
Sbjct: 449  GELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSK 508

Query: 1196 EIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPG 1255
             + +KL  LYG+  NID++   + E LV   R+GP L CLL  QF+++RDGDR W+ENPG
Sbjct: 509  MLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPG 568

Query: 1256 VFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVW 1312
            VF+  Q   +++ S +R++CDN   IT+V  D F    +P+ +  C  I ++DL  W
Sbjct: 569  VFTNEQKDSLQKMSFSRLVCDNT-RITKVPRDPFWANSYPYDFVDCSAIDKLDLSPW 624


>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
          Length = 876

 Score =  443 bits (1140), Expect = e-124
 Identities = 268/706 (37%), Positives = 376/706 (53%), Gaps = 82/706 (11%)

Query: 624  VATSIVEAIATVDRAINSTRTHLFDSRP-RSPNDLLALFRYPRDPYTVEQARAGEIFERT 682
            V++ + E+   VD A+ +T       R   SP  LL+  + P +P +   ARA EI E +
Sbjct: 39   VSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLP-EPTSGVIARAAEIMETS 97

Query: 683  LQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYR 742
            +Q ++  V           S H  D +S   L++IAN+SGC  +     C + C   KYR
Sbjct: 98   IQAMKRKVNLKTQ-----QSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 152

Query: 743  THDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTL 802
               G CNN  HP WGAS TA  R L  VYE+GF+ PRG NP  LYNG  LP  R V+  +
Sbjct: 153  PITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHV 212

Query: 803  I--GTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSV 860
            I    E VT D++++ +LM WGQ++DHD+  T  + S+A F  G  C   C N  PCF +
Sbjct: 213  IQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272

Query: 861  MIPPNDSRARSGARCMFFVRSSPVCGSGMTSLL---MNSVYPREQINQLTSYIDASNVYG 917
             +P  ++R  +G  C+ F RSS  CG+G    L   +++  PR+Q+N LTS++DAS VYG
Sbjct: 273  QLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYG 331

Query: 918  STEHEARSIRDLASHRGLLR-QGIVQRSGKPLLPFATG-PPTECMRDEN---ESPIPCFL 972
            S+    R +R+  S  GLLR    ++ SG+  LPF     P  C  +     E+  PCFL
Sbjct: 332  SSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFL 391

Query: 973  AGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQ 1032
            AGD RA+E   LT++HTLW REHNR+A  L  LN HW  D +Y E RK+VGA  Q IT +
Sbjct: 392  AGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLR 451

Query: 1033 HWLPKILG-EVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPI 1091
             ++P+ILG E   + +G Y GYD   N  + N F+TAAFRFGH  ++PL+ RLD +FQ  
Sbjct: 452  DYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQE- 510

Query: 1092 AQDHLP---LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAH 1148
                LP   LH+AFFSP+          LLRG                            
Sbjct: 511  -HPDLPGLWLHQAFFSPWT---------LLRG---------------------------- 532

Query: 1149 TVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGST 1208
                                 Y+++R +C L    T  DL   I +  + +K+  LY   
Sbjct: 533  --------------------GYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHP 572

Query: 1209 LNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQT 1268
             NID++   + E+ +P +R GP   CL+  Q K LRDGD  W+EN  VF+ AQ  ++++ 
Sbjct: 573  DNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKH 632

Query: 1269 SLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
            SL+R++CDN   +TRV  D F+V +FP  + SCD I  ++L  W++
Sbjct: 633  SLSRVICDNT-GLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 677


>gi|28558990 thyroid peroxidase isoform e [Homo sapiens]
          Length = 760

 Score =  256 bits (655), Expect = 9e-68
 Identities = 130/293 (44%), Positives = 190/293 (64%), Gaps = 7/293 (2%)

Query: 1026 IQHITYQHWLPKILG-EVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRL 1084
            IQ IT + ++P+ILG E   + +G Y GYD   N  + N F+TAAFRFGH  ++PL+ RL
Sbjct: 272  IQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRL 331

Query: 1085 DENFQPIAQDHLP---LHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTE 1141
            D +FQ      LP   LH+AFFSP+ ++  GG+DPL+RGL     K++V  QL+N ELTE
Sbjct: 332  DASFQE--HPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTE 389

Query: 1142 RLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKL 1201
            RLF ++++  LDLA+IN+QRGRDHG+P Y+++R +C L    T  DL   I +  + +K+
Sbjct: 390  RLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKI 449

Query: 1202 KRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQ 1261
              LY    NID++   + E+ +P +R GP   CL+  Q K LRDGD  W+EN  VF+ AQ
Sbjct: 450  LDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQ 509

Query: 1262 LTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
              ++++ SL+R++CDN   +TRV  D F+V +FP  + SCD I  ++L  W++
Sbjct: 510  RRELEKHSLSRVICDNT-GLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRE 561



 Score =  161 bits (407), Expect = 5e-39
 Identities = 94/242 (38%), Positives = 129/242 (53%), Gaps = 9/242 (3%)

Query: 624 VATSIVEAIATVDRAINSTRTHLFDSRP-RSPNDLLALFRYPRDPYTVEQARAGEIFERT 682
           V++ + E+   VD A+ +T       R   SP  LL+  + P +P +   ARA EI E +
Sbjct: 39  VSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLP-EPTSGVIARAAEIMETS 97

Query: 683 LQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYR 742
           +Q ++  V           S H  D +S   L++IAN+SGC  +     C + C   KYR
Sbjct: 98  IQAMKRKVNLKTQ-----QSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYR 152

Query: 743 THDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTL 802
              G CNN  HP WGAS TA  R L  VYE+GF+ PRG NP  LYNG  LP  R V+  +
Sbjct: 153 PITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHV 212

Query: 803 I--GTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSV 860
           I    E VT D++++ +LM WGQ++DHD+  T  + S+A F  G  C   C N  PCF +
Sbjct: 213 IQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPI 272

Query: 861 MI 862
            I
Sbjct: 273 QI 274


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score =  226 bits (575), Expect = 2e-58
 Identities = 150/476 (31%), Positives = 235/476 (49%), Gaps = 26/476 (5%)

Query: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
           L L FN +  +   +   L +L+ L L++N I  I  GAF+ L +L+ L L  NEI    
Sbjct: 312 LVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371

Query: 127 RQ---AFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLES 183
                AF GL SL +L L  N+I+++   +F  L  LE L L  N I  +    F  +++
Sbjct: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431

Query: 184 MKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNC 243
           +K L + S++  CDC++ WL   L        A   A C +P  ++G+S+ ++ PE   C
Sbjct: 432 LKELHISSDSFLCDCQLKWLPPWL--IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVC 489

Query: 244 E---RPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNNELSMKTDSRLNL--- 296
           +   +P+I ++P+      G  + FTC A   +  P     + +NE+    D    +   
Sbjct: 490 DDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVH 549

Query: 297 LDDGTLMIQNT-----QET--DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQ 349
             DG +M   T     Q T   +G YQC+  N  G   + +  L        P+F   P 
Sbjct: 550 AQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTV---NVLPSFTKTPH 606

Query: 350 NTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVNITPSGGLY-IQNVVQGD 406
           +  +       LEC+ATGHP P+I+W +   T  P   + R+++ P   ++ I +V   D
Sbjct: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666

Query: 407 SGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW 466
           +G Y+C+A N+  S+ A A + V   P   V  +DRVV  G+TV  QC+A GNPPP I W
Sbjct: 667 AGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITW 726

Query: 467 TKGGSQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQP 521
            KG   LS+ +R HL   +  L +  V   D G+Y C+  N +G+++  + L+V P
Sbjct: 727 FKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLP 782



 Score =  164 bits (414), Expect = 8e-40
 Identities = 159/596 (26%), Positives = 251/596 (42%), Gaps = 53/596 (8%)

Query: 65  SILDLRF--NRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEI 122
           S+L LR   NRI ++   AF+ L  L  L LN N+I+ I    F+ L +L+ L L +N I
Sbjct: 189 SLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247

Query: 123 QSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLE 182
             +   AF GL+ +  L+L +N +  ++  S   L  L +L L NN I  +    ++  +
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307

Query: 183 SMKRLRLD-SNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEEL 241
            +  L L  +N    D E L     L     S N+ +       + ++   V  +   E+
Sbjct: 308 KLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEI 367

Query: 242 NCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
           +      +      D  S  T+ F  + +   K     L     L++  ++  ++  D  
Sbjct: 368 SGTIEDTSGAFSGLDSLSKLTL-FGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426

Query: 302 LMIQNTQE----TDQGIYQCMAKNVA----GEVKTQEVTLR-----------YFGSPA-- 340
           + ++N +E    +D  +  C  K +     G +    VT              F  P   
Sbjct: 427 VKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPES 486

Query: 341 -------RPTFVIQPQNTEVLVGESVTLECSA--TGHPPPRISWTRGDR--TPLPVDPRV 389
                  +P  + QP+ T  +VG+ +   CSA  +   P   +W + +   T   ++  V
Sbjct: 487 FVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFV 546

Query: 390 NITPSGG--------LYIQNVVQGDSGEYACSATNNIDSVHA-TAFIIVQALPQFTVTPQ 440
           ++    G        L+++ V  G  G Y C  TN+  S ++  A + V  LP FT TP 
Sbjct: 547 HVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPH 606

Query: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHD 496
           D  +        +C A G+P P IAW K GG+     R    H++       I+ V + D
Sbjct: 607 DITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDD 666

Query: 497 QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAI 556
            G Y C A N  GS    A LTV    TP       D  V VG  V L C + G P P I
Sbjct: 667 AGVYSCTAQNSAGSISANATLTVLE--TPSLVVPLEDRVVSVGETVALQCKATGNPPPRI 724

Query: 557 TWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
           TW K    ++ + + H++P+   L + +V   DAGRY C   NT+G+      LSV
Sbjct: 725 TWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSV 780



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 65/186 (34%), Positives = 90/186 (48%), Gaps = 5/186 (2%)

Query: 12  CLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLR 70
           CLL L L          A  P A C + C C   ++ C    L A+P   P  T  L+L 
Sbjct: 17  CLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLS 76

Query: 71  FNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSIDRQA 129
           +N++ EI P  F  L NL  + LNNN++  +PS GA     ++  L+L  N+I+S++   
Sbjct: 77  YNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASS--HVVSLFLQHNKIRSVEGSQ 134

Query: 130 FKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMKRLR 188
            K   SLE L L  N I  +    F H P ++ L L  NRI  L  G F+ L  S+  LR
Sbjct: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194

Query: 189 LDSNTL 194
           L  N +
Sbjct: 195 LSKNRI 200



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 49/134 (36%), Positives = 73/134 (54%), Gaps = 2/134 (1%)

Query: 62  PQTSILDLRFNRIREIQPGAFRRL-RNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKN 120
           P    L+L  NRI  ++ GAF  L R+L TL L+ N+I ++P  AF+ L  L  L L +N
Sbjct: 163 PPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRN 221

Query: 121 EIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNH 180
            I+ I+   F+GL SLE L L  N I  L   +F  L K+  L L  N +  +  G+   
Sbjct: 222 RIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYG 281

Query: 181 LESMKRLRLDSNTL 194
           L ++ +L L +N++
Sbjct: 282 LTALHQLHLSNNSI 295


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score =  222 bits (566), Expect = 2e-57
 Identities = 153/505 (30%), Positives = 247/505 (48%), Gaps = 37/505 (7%)

Query: 50  MHLLLEAVPAVAPQT-------SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIP 102
           +HL   A+  ++P         S LDL FN +  +   +F  L  LNTL + NN++  I 
Sbjct: 292 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 351

Query: 103 SGAFEDLENLKYLYLYKNEIQ-SIDRQ--AFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
             AF  L +LK L L  NEI  +I+    AF GL  L +L L  N+I ++   +F  L  
Sbjct: 352 DCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA 411

Query: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAA 219
           LE L L +N I  L    F+ ++ +++L L++++L CDC++ WL      +    N Q+ 
Sbjct: 412 LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ----WVAENNFQSF 467

Query: 220 --AICEYPRRIQGRSVATITPEELNCE---RPRITSEPQDADVTSGNTVYFTCRA-EGNP 273
             A C +P+ ++GRS+  ++P+   C+   +P+IT +P+      G+ + F C A   + 
Sbjct: 468 VNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSD 527

Query: 274 KPEIIWLRNNNEL--SMKTDSRLNLLDDG--------TLMIQNTQETDQGIYQCMAKNVA 323
            P     + +NEL    + ++  +L   G         L ++  +   +G YQC+  N  
Sbjct: 528 SPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHF 587

Query: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383
           G   + +  L        P+F   P +  +  G    LEC+A GHP P+I+W +   T  
Sbjct: 588 GSSYSVKAKLTV---NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF 644

Query: 384 PV--DPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440
           P   + R+++ P   ++ I +V   D G Y+C+A N+  S+ A A + V   P F     
Sbjct: 645 PAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL 704

Query: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQ 499
           DR V +G+T   QC A G+PPP + WTK  S L V  RH   +   L  I    + D G+
Sbjct: 705 DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGK 764

Query: 500 YECQAVNIIGSQKVVAHLTVQPRVT 524
           Y C+  N +G+++    L+V P  T
Sbjct: 765 YTCEMSNTLGTERGNVRLSVIPTPT 789



 Score =  157 bits (398), Expect = 5e-38
 Identities = 158/592 (26%), Positives = 245/592 (41%), Gaps = 65/592 (10%)

Query: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
           L ++ N + ++  GAF  L N+  L L++N +  I  G    L  L+ L+L +N I  I 
Sbjct: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 303

Query: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
             A++    L +L L FN +  LD  SF  L  L  L + NNR++++    F  L S+K 
Sbjct: 304 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 363

Query: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI-QGRSVATITPEELNCER 245
           L L +N      EI W         E  N   + + +  R I QG  + +IT +      
Sbjct: 364 LDLKNN------EISWTI-------EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 410

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR--NNNELSMKTDSRLNLLDDGTLM 303
                +  D  + S          +GN   ++  L+  + N  S+  D +L  L      
Sbjct: 411 ALEHLDLSDNAIMS---------LQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP----- 456

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--------ARPTFVIQPQNTEVLV 355
               Q   +  +Q          +  +    +  SP         +P   +QP+    + 
Sbjct: 457 ----QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK 512

Query: 356 GESVTLECSA--TGHPPPRISWTRGDRT--PLPVDPRVNITPSGG--------LYIQNVV 403
           G +++  CSA  +   P   +W + +       ++   ++   GG        L ++ V 
Sbjct: 513 GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE 572

Query: 404 QGDSGEYACSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462
               G+Y C  +N+  S ++  A + V  LP FT TP D  +  G     +C A G+P P
Sbjct: 573 FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAP 632

Query: 463 VIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT 518
            IAW K GG+     R    H++       I  V + D G Y C A N  GS    A LT
Sbjct: 633 QIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT 692

Query: 519 VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPE 576
           V    TP F     D TV  G    L C + G P P + W KD   + VTE   F  +  
Sbjct: 693 VLE--TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER-HFFAAGN 749

Query: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 628
             L I D   +DAG+Y C   NT+G+   ++ LSV +P  + +     A S+
Sbjct: 750 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMTAPSL 800



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 4/144 (2%)

Query: 53  LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRN-LNTLLLNNNQIKRIPSGAFEDLEN 111
           L  A PA+  Q   L L  NR+  ++PG F  L N L  L LN N+I  IP   F+ L  
Sbjct: 160 LQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 216

Query: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRIT 171
           L++L L +N+I+++D   F+GL +L+ L +  N +  L   +F  L  +E L L +N +T
Sbjct: 217 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 276

Query: 172 HLVPGTFNHLESMKRLRLDSNTLH 195
            +  G    L  ++ L L  N ++
Sbjct: 277 EITKGWLYGLLMLQELHLSQNAIN 300



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 56/171 (32%), Positives = 89/171 (52%), Gaps = 10/171 (5%)

Query: 27  VVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQ-TSILDLRFNRIREIQPGAFRRL 85
           V A++P   CP+ C C    + C    L  +P   P   + LDL  NR+  I+  +   L
Sbjct: 41  VAAERP---CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHL 97

Query: 86  RNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFN 144
           ++L  + LNNN+++ IP+ G      N+  L L  N I  I  +  K   SLE L L  N
Sbjct: 98  QSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSN 155

Query: 145 QIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMKRLRLDSNTL 194
            I  L   +F  L +L+ L+L++NR+T + PG F++L  ++  L+L+ N +
Sbjct: 156 NISELQ-TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRI 204


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score =  222 bits (566), Expect = 2e-57
 Identities = 153/505 (30%), Positives = 247/505 (48%), Gaps = 37/505 (7%)

Query: 50  MHLLLEAVPAVAPQT-------SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIP 102
           +HL   A+  ++P         S LDL FN +  +   +F  L  LNTL + NN++  I 
Sbjct: 232 LHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIA 291

Query: 103 SGAFEDLENLKYLYLYKNEIQ-SIDRQ--AFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
             AF  L +LK L L  NEI  +I+    AF GL  L +L L  N+I ++   +F  L  
Sbjct: 292 DCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDA 351

Query: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAA 219
           LE L L +N I  L    F+ ++ +++L L++++L CDC++ WL      +    N Q+ 
Sbjct: 352 LEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQ----WVAENNFQSF 407

Query: 220 --AICEYPRRIQGRSVATITPEELNCE---RPRITSEPQDADVTSGNTVYFTCRA-EGNP 273
             A C +P+ ++GRS+  ++P+   C+   +P+IT +P+      G+ + F C A   + 
Sbjct: 408 VNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSD 467

Query: 274 KPEIIWLRNNNEL--SMKTDSRLNLLDDG--------TLMIQNTQETDQGIYQCMAKNVA 323
            P     + +NEL    + ++  +L   G         L ++  +   +G YQC+  N  
Sbjct: 468 SPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHF 527

Query: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383
           G   + +  L        P+F   P +  +  G    LEC+A GHP P+I+W +   T  
Sbjct: 528 GSSYSVKAKLTV---NMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDF 584

Query: 384 PV--DPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQ 440
           P   + R+++ P   ++ I +V   D G Y+C+A N+  S+ A A + V   P F     
Sbjct: 585 PAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLL 644

Query: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQ 499
           DR V +G+T   QC A G+PPP + WTK  S L V  RH   +   L  I    + D G+
Sbjct: 645 DRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGK 704

Query: 500 YECQAVNIIGSQKVVAHLTVQPRVT 524
           Y C+  N +G+++    L+V P  T
Sbjct: 705 YTCEMSNTLGTERGNVRLSVIPTPT 729



 Score =  157 bits (398), Expect = 5e-38
 Identities = 158/592 (26%), Positives = 245/592 (41%), Gaps = 65/592 (10%)

Query: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
           L ++ N + ++  GAF  L N+  L L++N +  I  G    L  L+ L+L +N I  I 
Sbjct: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243

Query: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
             A++    L +L L FN +  LD  SF  L  L  L + NNR++++    F  L S+K 
Sbjct: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKT 303

Query: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI-QGRSVATITPEELNCER 245
           L L +N      EI W         E  N   + + +  R I QG  + +IT +      
Sbjct: 304 LDLKNN------EISWTI-------EDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLD 350

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR--NNNELSMKTDSRLNLLDDGTLM 303
                +  D  + S          +GN   ++  L+  + N  S+  D +L  L      
Sbjct: 351 ALEHLDLSDNAIMS---------LQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP----- 396

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--------ARPTFVIQPQNTEVLV 355
               Q   +  +Q          +  +    +  SP         +P   +QP+    + 
Sbjct: 397 ----QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIK 452

Query: 356 GESVTLECSA--TGHPPPRISWTRGDRT--PLPVDPRVNITPSGG--------LYIQNVV 403
           G +++  CSA  +   P   +W + +       ++   ++   GG        L ++ V 
Sbjct: 453 GSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVE 512

Query: 404 QGDSGEYACSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462
               G+Y C  +N+  S ++  A + V  LP FT TP D  +  G     +C A G+P P
Sbjct: 513 FASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAP 572

Query: 463 VIAWTK-GGSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT 518
            IAW K GG+     R    H++       I  V + D G Y C A N  GS    A LT
Sbjct: 573 QIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLT 632

Query: 519 VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDG--VQVTESGKFHISPE 576
           V    TP F     D TV  G    L C + G P P + W KD   + VTE   F  +  
Sbjct: 633 VLE--TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTER-HFFAAGN 689

Query: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSI 628
             L I D   +DAG+Y C   NT+G+   ++ LSV +P  + +     A S+
Sbjct: 690 QLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSV-IPTPTCDSPQMTAPSL 740



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 49/144 (34%), Positives = 76/144 (52%), Gaps = 4/144 (2%)

Query: 53  LLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRN-LNTLLLNNNQIKRIPSGAFEDLEN 111
           L  A PA+  Q   L L  NR+  ++PG F  L N L  L LN N+I  IP   F+ L  
Sbjct: 100 LQTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQ 156

Query: 112 LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRIT 171
           L++L L +N+I+++D   F+GL +L+ L +  N +  L   +F  L  +E L L +N +T
Sbjct: 157 LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLT 216

Query: 172 HLVPGTFNHLESMKRLRLDSNTLH 195
            +  G    L  ++ L L  N ++
Sbjct: 217 EITKGWLYGLLMLQELHLSQNAIN 240



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 6/129 (4%)

Query: 68  DLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPS-GAFEDLENLKYLYLYKNEIQSID 126
           DL  NR+  I+  +   L++L  + LNNN+++ IP+ G      N+  L L  N I  I 
Sbjct: 20  DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS--ANITLLSLAGNRIVEIL 77

Query: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL-ESMK 185
            +  K   SLE L L  N I  L   +F  L +L+ L+L++NR+T + PG F++L  ++ 
Sbjct: 78  PEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLL 135

Query: 186 RLRLDSNTL 194
            L+L+ N +
Sbjct: 136 VLKLNRNRI 144


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  206 bits (523), Expect = 2e-52
 Identities = 140/400 (35%), Positives = 186/400 (46%), Gaps = 21/400 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
           GD G Y C A N +    A+A + VQ  P F V P+D+VV  G+TV FQCEA GNP P I
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAI 343

Query: 465 AWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
            W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS    A+
Sbjct: 344 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 403

Query: 517 L----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TESGKF 571
           L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+  + 
Sbjct: 404 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRI 463

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
                G L I      D GRY C+A    G A+ S  + V
Sbjct: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 503



 Score =  190 bits (483), Expect = 8e-48
 Identities = 131/400 (32%), Positives = 180/400 (45%), Gaps = 32/400 (8%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ    P F   P D 
Sbjct: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE--PPHFVVKPRDQ 321

Query: 535 TVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGP 586
            V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V  
Sbjct: 322 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381

Query: 587 ADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
           +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421



 Score =  143 bits (360), Expect = 1e-33
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 27/413 (6%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +    TL        P FV++P++  V +G +VT +C
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEAS-ATLTV---QEPPHFVVKPRDQVVALGRTVTFQC 333

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 334 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 453

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 454 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 513

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 514 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 573

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 574 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 626



 Score =  100 bits (249), Expect = 1e-20
 Identities = 69/205 (33%), Positives = 94/205 (45%), Gaps = 12/205 (5%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T +E     P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 304 ATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 359

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 420 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEVQ 504


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  206 bits (523), Expect = 2e-52
 Identities = 136/412 (33%), Positives = 201/412 (48%), Gaps = 23/412 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V +G      C+   G+P+P I W ++  
Sbjct: 129 RNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV 188

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            +  K + R+++   G LMI NT+++D G+Y C+  N+ GE  +    L  F    RPTF
Sbjct: 189 RIDDK-EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF---ERPTF 243

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           + +P N  VL  E+V   C   G P P + W + D   LP   R +I     L I+  + 
Sbjct: 244 LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD-ADLPRG-RYDIKDDYTLRIKKTMS 301

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
            D G Y C A N +  + A+A + V+A PQF V P+D++V +G+TV F CE KGNP P +
Sbjct: 302 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 361

Query: 465 AWTKGGSQ--------LSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
            W K GSQ           + R  V  +G L I+ +   D G Y CQA+ + GS    A 
Sbjct: 362 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 421

Query: 517 LTVQPRVT----PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-ESGKF 571
           L V   +T    P+    P++ T+ V     L C + G+P P I+W K+G        + 
Sbjct: 422 LEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRA 481

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV--NVPDVSRNGD 621
            I  +G L I ++  +D G Y CVA ++ G  S S VL V  +   +S+N D
Sbjct: 482 TIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYD 533



 Score =  184 bits (468), Expect = 4e-46
 Identities = 124/384 (32%), Positives = 175/384 (45%), Gaps = 24/384 (6%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W ++   +    D   S   LL  G+L
Sbjct: 47  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 106

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                      + D+G Y C+A+N  GE  ++  +L    +  R  F   P +  V  GE
Sbjct: 107 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV--ALLRDDFRQNPTDVVVAAGE 164

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
              LEC    GHP P I W +        + R++I   G L I N  + D+G Y C  TN
Sbjct: 165 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 223

Query: 417 NIDSVHA-TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
            +    +  A + V   P F   P ++VV+E + V+F+C+ +G+P P + W K  + L  
Sbjct: 224 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 282

Query: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
             R+ +    TLRI      D+G Y C A N +G  +  A LTV  R  P F   P D  
Sbjct: 283 RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVRPRDQI 340

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGPA 587
           V  G  V  PC ++G P+PA+ W K+G Q           + +  +SP G LTI ++  +
Sbjct: 341 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 400

Query: 588 DAGRYECVARNTIGSASVSMVLSV 611
           DAG Y C A    GS      L V
Sbjct: 401 DAGYYICQALTVAGSILAKAQLEV 424


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  206 bits (523), Expect = 2e-52
 Identities = 136/412 (33%), Positives = 201/412 (48%), Gaps = 23/412 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V +G      C+   G+P+P I W ++  
Sbjct: 113 RNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKV 172

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            +  K + R+++   G LMI NT+++D G+Y C+  N+ GE  +    L  F    RPTF
Sbjct: 173 RIDDK-EERISIRG-GKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF---ERPTF 227

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           + +P N  VL  E+V   C   G P P + W + D   LP   R +I     L I+  + 
Sbjct: 228 LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDD-ADLPRG-RYDIKDDYTLRIKKTMS 285

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
            D G Y C A N +  + A+A + V+A PQF V P+D++V +G+TV F CE KGNP P +
Sbjct: 286 TDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAV 345

Query: 465 AWTKGGSQ--------LSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
            W K GSQ           + R  V  +G L I+ +   D G Y CQA+ + GS    A 
Sbjct: 346 FWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQ 405

Query: 517 LTVQPRVT----PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-ESGKF 571
           L V   +T    P+    P++ T+ V     L C + G+P P I+W K+G        + 
Sbjct: 406 LEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRA 465

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV--NVPDVSRNGD 621
            I  +G L I ++  +D G Y CVA ++ G  S S VL V  +   +S+N D
Sbjct: 466 TIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYD 517



 Score =  184 bits (468), Expect = 4e-46
 Identities = 124/384 (32%), Positives = 175/384 (45%), Gaps = 24/384 (6%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W ++   +    D   S   LL  G+L
Sbjct: 31  PRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSL 90

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                      + D+G Y C+A+N  GE  ++  +L    +  R  F   P +  V  GE
Sbjct: 91  FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV--ALLRDDFRQNPTDVVVAAGE 148

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
              LEC    GHP P I W +        + R++I   G L I N  + D+G Y C  TN
Sbjct: 149 PAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIR-GGKLMISNTRKSDAGMYTCVGTN 207

Query: 417 NIDSVHA-TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
            +    +  A + V   P F   P ++VV+E + V+F+C+ +G+P P + W K  + L  
Sbjct: 208 MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP- 266

Query: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
             R+ +    TLRI      D+G Y C A N +G  +  A LTV  R  P F   P D  
Sbjct: 267 RGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV--RAPPQFVVRPRDQI 324

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGPA 587
           V  G  V  PC ++G P+PA+ W K+G Q           + +  +SP G LTI ++  +
Sbjct: 325 VAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRS 384

Query: 588 DAGRYECVARNTIGSASVSMVLSV 611
           DAG Y C A    GS      L V
Sbjct: 385 DAGYYICQALTVAGSILAKAQLEV 408


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  206 bits (523), Expect = 2e-52
 Identities = 140/400 (35%), Positives = 186/400 (46%), Gaps = 21/400 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 150 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 209

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 210 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 264

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 265 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 322

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
           GD G Y C A N +    A+A + VQ  P F V P+D+VV  G+TV FQCEA GNP P I
Sbjct: 323 GDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAI 382

Query: 465 AWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
            W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS    A+
Sbjct: 383 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 442

Query: 517 L----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TESGKF 571
           L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+  + 
Sbjct: 443 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRI 502

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
                G L I      D GRY C+A    G A+ S  + V
Sbjct: 503 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 542



 Score =  190 bits (483), Expect = 8e-48
 Identities = 131/400 (32%), Positives = 180/400 (45%), Gaps = 32/400 (8%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 185

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 186 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 243

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 303

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ    P F   P D 
Sbjct: 304 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE--PPHFVVKPRDQ 360

Query: 535 TVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGP 586
            V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V  
Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420

Query: 587 ADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
           +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460



 Score =  143 bits (360), Expect = 1e-33
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 27/413 (6%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 260 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 316

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +    TL        P FV++P++  V +G +VT +C
Sbjct: 317 IRKVTAGDMGSYTCVAENMVGKAEAS-ATLTV---QEPPHFVVKPRDQVVALGRTVTFQC 372

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 373 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 432

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 433 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 492

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 493 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 552

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 553 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 612

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 613 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 665



 Score =  100 bits (249), Expect = 1e-20
 Identities = 69/205 (33%), Positives = 94/205 (45%), Gaps = 12/205 (5%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T +E     P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 343 ATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 398

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 399 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 458

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 459 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 519 DTGRYTCIASTPSGEATWSAYIEVQ 543


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score =  204 bits (519), Expect = 5e-52
 Identities = 148/479 (30%), Positives = 227/479 (47%), Gaps = 33/479 (6%)

Query: 65  SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ- 123
           S LDL +N++  +   AF  L  L  L L +N++  I  G F  L NL+ L L  NEI  
Sbjct: 314 SELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISW 373

Query: 124 SID--RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL 181
           +I+   +AF GL SL +L L  NQI+++   +F  L  LE L L+NN I  +    F+  
Sbjct: 374 AIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT 433

Query: 182 ESMKRLRLDSNTLHCDCEILWLADLL--KTYAESGNAQAAAICEYPRRIQGRSVATITPE 239
             +K L L++++L CDC + WL   L    +  S N      C +P  + G+S+  +  +
Sbjct: 434 H-LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVS----CAHPEWLAGQSILNVDLK 488

Query: 240 ELNCE---RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEI--IWLRNNNELSMKTDSRL 294
           +  C+   +P+I + P+      G  V  TC A  +    +  +W R ++E+    D+  
Sbjct: 489 DFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVW-RKDSEILYDVDTEN 547

Query: 295 ----------NLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
                      L     L + N   TD+G YQC+  N  G   +Q+  L        P+F
Sbjct: 548 FVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSF 604

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVNITPSGGLY-IQN 401
           +  P +  +  G    LEC+A GHP P+ISW +   T  P   + R+++ P   ++ I N
Sbjct: 605 LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIAN 664

Query: 402 VVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
           V   D G Y+C A N    + A A + V   P F    +D+ V  G+T   QC A G+P 
Sbjct: 665 VKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPA 724

Query: 462 PVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQYECQAVNIIGSQKVVAHLTV 519
           P + WTK    L V  RH   ++  L  I    L D G+Y C   N +G+++   +L V
Sbjct: 725 PRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783



 Score =  177 bits (450), Expect = 5e-44
 Identities = 159/566 (28%), Positives = 245/566 (43%), Gaps = 47/566 (8%)

Query: 67  LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
           L ++ N I +++ GAF  L N+  L L +N + R+  G    L  L+ LY+ +N I+ I 
Sbjct: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303

Query: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
             A++    L +L L +NQ+  LD  +F  L  LERL L +NR+TH+  G F  L +++ 
Sbjct: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363

Query: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE-LNCER 245
           L L +N      EI W  +      ++  A A         +QG  + +IT +  +  E 
Sbjct: 364 LDLRNN------EISWAIE------DASEAFAGLTSLTKLILQGNQIKSITKKAFIGLE- 410

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
              + E  D +  +  ++     ++ + K  I+     N  S+  D  L  L     ++ 
Sbjct: 411 ---SLEHLDLNNNAIMSIQENAFSQTHLKELIL-----NTSSLLCDCHLKWLLQW--LVD 460

Query: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--ARPTFVIQPQNTEVLVGESVTLEC 363
           N  +    +     + +AG+     V L+ F      +P     P+    L G +VTL C
Sbjct: 461 NNFQHSVNVSCAHPEWLAGQ-SILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTC 519

Query: 364 SA--TGHPPPRISWTRGDRTPLPVDPR--VNITPSGG--------LYIQNVVQGDSGEYA 411
           +A  +   P    W +       VD    V      G        L++ NV   D G+Y 
Sbjct: 520 TAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQ 579

Query: 412 CSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK-G 469
           C  TN+  S ++  A + V  +P F  TP D  +  G     +C A+G+P P I+W K G
Sbjct: 580 CIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG 639

Query: 470 GSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526
           G+     R    H++       I+ V + D G Y C A N  G     A LTV    TP 
Sbjct: 640 GTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLE--TPS 697

Query: 527 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKD-GVQVTESGKFHISPEGFLTINDVG 585
           F     D TV  G    L C + G P P + W KD G  +     F  +    L I D G
Sbjct: 698 FIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAG 757

Query: 586 PADAGRYECVARNTIGSASVSMVLSV 611
             DAG+Y C+  NT+G+    + L+V
Sbjct: 758 LEDAGKYTCIMSNTLGTERGHIYLNV 783



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 51/155 (32%), Positives = 82/155 (52%), Gaps = 7/155 (4%)

Query: 45  TTVRCMHLLLEAVPAVA----PQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKR 100
           T +  +H ++  + A A    P    LDL  N I EI+  +F R++ L  L L+NN+I  
Sbjct: 123 TLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITT 181

Query: 101 IPSGAFEDLEN-LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
           + +G F++L + L  + L +N +  I  + FK L  L+ L L  N+I+ ++  +FQ L  
Sbjct: 182 LEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDS 240

Query: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL 194
           L  L +  N I+ L  G F  L +M+ L L+ N L
Sbjct: 241 LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 55/180 (30%), Positives = 80/180 (44%), Gaps = 10/180 (5%)

Query: 10  RRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVP------AVAPQ 63
           R  +L+ +LF A   L ++       CP+ C C    + C    L A         + P 
Sbjct: 17  RSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPD 76

Query: 64  TSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ 123
           T+ILD   NR+           + L  + +N N++  IP    E   N+  L L  N I 
Sbjct: 77  TAILDFSHNRLSNWNISL--ESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIP 133

Query: 124 SIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLES 183
            I+ QA +   +LE L L  N I  +   SF  + +L+ L L NNRIT L  G F++L S
Sbjct: 134 EINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSS 192


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  201 bits (510), Expect = 6e-51
 Identities = 140/403 (34%), Positives = 186/403 (46%), Gaps = 24/403 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQA---LPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
           GD G Y C A N +    A+A + VQ     P F V P+D+VV  G+TV FQCEA GNP 
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343

Query: 462 PVIAWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513
           P I W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS   
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403

Query: 514 VAHL----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TES 568
            A+L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+ 
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 463

Query: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
            +      G L I      D GRY C+A    G A+ S  + V
Sbjct: 464 SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score =  189 bits (480), Expect = 2e-47
 Identities = 131/401 (32%), Positives = 180/401 (44%), Gaps = 31/401 (7%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSD 533
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ     P F   P D
Sbjct: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323

Query: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVG 585
             V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V 
Sbjct: 324 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383

Query: 586 PADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
            +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 384 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424



 Score =  147 bits (371), Expect = 7e-35
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 24/413 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +         GS   P FV++P++  V +G +VT +C
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP-PHFVVKPRDQVVALGRTVTFQC 336

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 397 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 456

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 457 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 517 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 576

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 629



 Score =  101 bits (252), Expect = 5e-21
 Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 9/205 (4%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T + +  E P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 304 ATLTVQ-VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQ 507


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  201 bits (510), Expect = 6e-51
 Identities = 140/403 (34%), Positives = 186/403 (46%), Gaps = 24/403 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQA---LPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
           GD G Y C A N +    A+A + VQ     P F V P+D+VV  G+TV FQCEA GNP 
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343

Query: 462 PVIAWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513
           P I W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS   
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403

Query: 514 VAHL----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TES 568
            A+L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+ 
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 463

Query: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
            +      G L I      D GRY C+A    G A+ S  + V
Sbjct: 464 SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score =  189 bits (480), Expect = 2e-47
 Identities = 131/401 (32%), Positives = 180/401 (44%), Gaps = 31/401 (7%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSD 533
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ     P F   P D
Sbjct: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323

Query: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVG 585
             V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V 
Sbjct: 324 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383

Query: 586 PADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
            +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 384 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424



 Score =  147 bits (371), Expect = 7e-35
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 24/413 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +         GS   P FV++P++  V +G +VT +C
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP-PHFVVKPRDQVVALGRTVTFQC 336

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 397 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 456

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 457 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 517 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 576

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 629



 Score =  101 bits (252), Expect = 5e-21
 Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 9/205 (4%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T + +  E P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 304 ATLTVQ-VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQ 507


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  201 bits (510), Expect = 6e-51
 Identities = 140/403 (34%), Positives = 186/403 (46%), Gaps = 24/403 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQA---LPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
           GD G Y C A N +    A+A + VQ     P F V P+D+VV  G+TV FQCEA GNP 
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343

Query: 462 PVIAWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513
           P I W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS   
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403

Query: 514 VAHL----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TES 568
            A+L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+ 
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 463

Query: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
            +      G L I      D GRY C+A    G A+ S  + V
Sbjct: 464 SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score =  189 bits (480), Expect = 2e-47
 Identities = 131/401 (32%), Positives = 180/401 (44%), Gaps = 31/401 (7%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSD 533
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ     P F   P D
Sbjct: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323

Query: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVG 585
             V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V 
Sbjct: 324 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383

Query: 586 PADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
            +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 384 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424



 Score =  147 bits (371), Expect = 7e-35
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 24/413 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +         GS   P FV++P++  V +G +VT +C
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP-PHFVVKPRDQVVALGRTVTFQC 336

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 397 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 456

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 457 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 517 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 576

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 629



 Score =  101 bits (252), Expect = 5e-21
 Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 9/205 (4%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T + +  E P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 304 ATLTVQ-VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQ 507


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  201 bits (510), Expect = 6e-51
 Identities = 140/403 (34%), Positives = 186/403 (46%), Gaps = 24/403 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQA---LPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
           GD G Y C A N +    A+A + VQ     P F V P+D+VV  G+TV FQCEA GNP 
Sbjct: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343

Query: 462 PVIAWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513
           P I W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS   
Sbjct: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403

Query: 514 VAHL----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TES 568
            A+L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+ 
Sbjct: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 463

Query: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
            +      G L I      D GRY C+A    G A+ S  + V
Sbjct: 464 SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506



 Score =  189 bits (480), Expect = 2e-47
 Identities = 131/401 (32%), Positives = 180/401 (44%), Gaps = 31/401 (7%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146

Query: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204

Query: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264

Query: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSD 533
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ     P F   P D
Sbjct: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323

Query: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVG 585
             V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V 
Sbjct: 324 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383

Query: 586 PADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
            +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 384 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424



 Score =  147 bits (371), Expect = 7e-35
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 24/413 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I+     D G Y C+A+N+ G+ +         GS   P FV++P++  V +G +VT +C
Sbjct: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP-PHFVVKPRDQVVALGRTVTFQC 336

Query: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396

Query: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 397 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 456

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 457 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 517 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 576

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 577 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 629



 Score =  101 bits (252), Expect = 5e-21
 Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 9/205 (4%)

Query: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
           AT+T + +  E P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 304 ATLTVQ-VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362

Query: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422

Query: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482

Query: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
           D+G Y C A+        +A+I VQ
Sbjct: 483 DTGRYTCIASTPSGEATWSAYIEVQ 507


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  199 bits (507), Expect = 1e-50
 Identities = 138/428 (32%), Positives = 196/428 (45%), Gaps = 28/428 (6%)

Query: 221  ICEYPR---RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPE 276
            ICE      +IQ  +  T+T        P I   P  A+V  G  +   C    GNP PE
Sbjct: 866  ICEAENQFGKIQSETTVTVT----GLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPE 921

Query: 277  IIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAG-EVKTQEVTLRY 335
              W++N+  L    +  + +  DG+L I+  Q  D G Y C+A NVAG   KT  V +  
Sbjct: 922  RRWIKNSAMLLQ--NPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHV 979

Query: 336  FGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSG 395
                  PT     Q    + G  VTL C A+G+P P + W++          + +    G
Sbjct: 980  L-----PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG 1034

Query: 396  GLYIQNVVQGDSGEYACSATNNID----SVHATAFIIVQALPQFTVTPQDRVV----IEG 447
             LY+ +    +SGEY C+ATN        V  T ++  +         QD+ V    + G
Sbjct: 1035 SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAG 1094

Query: 448  QTVDFQCEAKGNPPPVIAWTKGGSQLS-VDRRHLVLSSGTLRISGVALHDQGQYECQAVN 506
            + V   CE K  PPP+I W K    +S    RH  L SG+++I+     D G Y C A N
Sbjct: 1095 EEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN 1154

Query: 507  IIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT 566
            I G+      L V   V P     P    V+VG  V +PC++QG P P ITW+K G  + 
Sbjct: 1155 IAGNVTQAVKLNVH--VPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTML 1212

Query: 567  ESGKFHIS-PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVA 625
              G+ H+S P+G L+I+   P+DAG Y CVA N  G+    + L V  P    + +P   
Sbjct: 1213 VDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYN 1272

Query: 626  TSIVEAIA 633
            T+  E +A
Sbjct: 1273 TTFQERVA 1280



 Score =  199 bits (505), Expect = 2e-50
 Identities = 135/395 (34%), Positives = 179/395 (45%), Gaps = 13/395 (3%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I    Q      G  V   C+A GNPKP +IW +   EL   + ++ +   DG+L + 
Sbjct: 981  PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKG-ELISTSSAKFSAGADGSLYVV 1039

Query: 306  NTQETDQGIYQCMAKNVAGEVK-----TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
            +    + G Y C A N AG  K     T  V  R FG   R     +P    VL GE VT
Sbjct: 1040 SPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQ-RGLSQDKPVEISVLAGEEVT 1098

Query: 361  LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420
            L C     PPP I+W +  +   P  PR    PSG + I      DSG Y C ATN   +
Sbjct: 1099 LPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGN 1158

Query: 421  VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480
            V     + V   P+    P+   V  GQ VD  C A+G P PVI W+KGGS + VD  H 
Sbjct: 1159 VTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHH 1218

Query: 481  VLS-SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVE-- 537
            V +  GTL I      D G Y C A NI G+ +    L VQ   T      P +TT +  
Sbjct: 1219 VSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQER 1278

Query: 538  -VGANVQLPCSSQGEPEPAITWNKDGVQVT--ESGKFHISPEGFLTINDVGPADAGRYEC 594
                 ++ PC ++G P+P I W  +G ++T  E G   +     L I  V P D G Y C
Sbjct: 1279 VANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYIC 1338

Query: 595  VARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIV 629
            VA N  G+      L V+VP V ++ +     S++
Sbjct: 1339 VAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVL 1373



 Score =  197 bits (501), Expect = 6e-50
 Identities = 132/371 (35%), Positives = 173/371 (46%), Gaps = 12/371 (3%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I  EP D  VT       TC A G P P I W +N   L  + D    +L  G + I 
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDG-YRILSSGAIEIL 3955

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE--VLVGESVTLEC 363
             TQ    G Y C+A+N AG    + VTL     P     VIQPQ +E  V++   + L C
Sbjct: 3956 ATQLNHAGRYTCVARNAAGSAH-RHVTLHVHEPP-----VIQPQPSELHVILNNPILLPC 4009

Query: 364  SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
             ATG P P I+W +             + PSGGL I   V+ D+G Y C A N   +   
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG 4069

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
               + VQ  P  +   ++ V+   + +   CEA G PPP I W K G  +    R  VLS
Sbjct: 4070 KIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLS 4129

Query: 484  SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
            SG+L+I+ V   D G Y C A N+ GS      LTV   V P   S     TV   +   
Sbjct: 4130 SGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV--HVPPRIRSTEGHYTVNENSQAI 4187

Query: 544  LPCSSQGEPEPAITWNKDGVQVTE-SGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
            LPC + G P PAI W KD V +    GK+   P G L + +V   D+G Y CVA N  G 
Sbjct: 4188 LPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGE 4247

Query: 603  ASVSMVLSVNV 613
             + ++ L+V+V
Sbjct: 4248 DTHTVSLTVHV 4258



 Score =  195 bits (496), Expect = 2e-49
 Identities = 134/399 (33%), Positives = 185/399 (46%), Gaps = 20/399 (5%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I   PQ   +    +    C AEG P P I W R +  +     +R ++L++G L IQ
Sbjct: 3713 PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQ 3771

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
            +   TD G Y CMA N AG  + + + L+       P+    P N  V+V    TL C A
Sbjct: 3772 SAHVTDTGRYLCMATNAAGTDR-RRIDLQVH---VPPSIAPGPTNMTVIVNVQTTLACEA 3827

Query: 366  TGHPPPRISWTRGDRTPLPVDPRVN---ITPSGGLYIQNVVQGDSGEYACSATNNIDSVH 422
            TG P P I+W +     L VD   N   +  SG L I +    D+  Y C+ TN      
Sbjct: 3828 TGIPKPSINWRKNGHL-LNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDK 3886

Query: 423  ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHLV 481
             T  + VQ  P     P D +V +       C A G P P I WTK G +L      + +
Sbjct: 3887 RTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRI 3946

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            LSSG + I    L+  G+Y C A N  GS     H+T+     PV    PS+  V +   
Sbjct: 3947 LSSGAIEILATQLNHAGRYTCVARNAAGSAH--RHVTLHVHEPPVIQPQPSELHVILNNP 4004

Query: 542  VQLPCSSQGEPEPAITWNKDGVQVTESGKFH-ISPEGFLTINDVGPADAGRYECVARNTI 600
            + LPC + G P P ITW K+G+ V  SG+ H + P G L I+     DAG Y CVA+N  
Sbjct: 4005 ILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPA 4064

Query: 601  GSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAI 639
            G+A   + L+V VP       P ++  + E +  VD+ I
Sbjct: 4065 GTALGKIKLNVQVP-------PVISPHLKEYVIAVDKPI 4096



 Score =  189 bits (479), Expect = 2e-47
 Identities = 129/373 (34%), Positives = 174/373 (46%), Gaps = 13/373 (3%)

Query: 249  TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMIQNT 307
            T EP+D  V     V   C+++  P P I WLRN   L  +   R+ +L  G  L I N 
Sbjct: 3625 TDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERL--QATPRVRILSGGRYLQINNA 3682

Query: 308  QETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATG 367
               D   Y C+A N+AG+  T+E  L        P     PQ+  +L+ +S  LEC A G
Sbjct: 3683 DLGDTANYTCVASNIAGKT-TREFILTV---NVPPNIKGGPQSLVILLNKSTVLECIAEG 3738

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFI 427
             P PRI+W +          R +I  +G L+IQ+    D+G Y C ATN   +      +
Sbjct: 3739 VPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDL 3798

Query: 428  IVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR---HLVLSS 484
             V   P     P +  VI        CEA G P P I W K G  L+VD+    + +LSS
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSS 3858

Query: 485  GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQL 544
            G+L I   ++ D   YEC   N  G  K    LTVQ  V P  A  P+D  V   A   +
Sbjct: 3859 GSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQ--VPPSIADEPTDFLVTKHAPAVI 3916

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGK-FHISPEGFLTINDVGPADAGRYECVARNTIGSA 603
             C++ G P P+I W K+G+++   G  + I   G + I       AGRY CVARN  GSA
Sbjct: 3917 TCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSA 3976

Query: 604  SVSMVLSVNVPDV 616
               + L V+ P V
Sbjct: 3977 HRHVTLHVHEPPV 3989



 Score =  185 bits (469), Expect = 3e-46
 Identities = 118/370 (31%), Positives = 171/370 (46%), Gaps = 12/370 (3%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            PRI S      V   +     C A+G P P I W + +N L      +      G L+++
Sbjct: 4169 PRIRSTEGHYTVNENSQAILPCVADGIPTPAINW-KKDNVLLANLLGKYTAEPYGELILE 4227

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
            N    D G Y C+A N AGE  T  V+L        PTF   P +  +  GE + L C A
Sbjct: 4228 NVVLEDSGFYTCVANNAAGE-DTHTVSLTVH---VLPTFTELPGDVSLNKGEQLRLSCKA 4283

Query: 366  TGHPPPRISWTRGDRT-PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHAT 424
            TG P P+++WT  +   P   D   ++     L I+ V + DSG Y C+A N++  V A 
Sbjct: 4284 TGIPLPKLTWTFNNNIIPAHFD---SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAI 4340

Query: 425  AFIIVQALPQFTVT-PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
             F+ V+  P F    P + +   G      CE KG+P P I W + G  + +  R   L 
Sbjct: 4341 GFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLG 4400

Query: 484  SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
            +G+L I G    D G Y C A N  G  +    LT+Q    P+    P +T +  G  + 
Sbjct: 4401 NGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQS--PPIITLEPVETVINAGGKII 4458

Query: 544  LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSA 603
            L C + GEP+P ITW++ G  ++   + ++     L I D    D   +ECVARN +GS 
Sbjct: 4459 LNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSV 4518

Query: 604  SVSMVLSVNV 613
             V + + V V
Sbjct: 4519 LVRVPVIVQV 4528



 Score =  182 bits (462), Expect = 2e-45
 Identities = 123/372 (33%), Positives = 168/372 (45%), Gaps = 10/372 (2%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM-KTDSRLNLLDDGTLMI 304
            P I   P +  V         C A G PKP I W +N + L++ +  +   LL  G+L+I
Sbjct: 3804 PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVI 3863

Query: 305  QNTQETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
             +    D   Y+C   N AG+ K T ++T++       P+   +P +  V       + C
Sbjct: 3864 ISPSVDDTATYECTVTNGAGDDKRTVDLTVQ-----VPPSIADEPTDFLVTKHAPAVITC 3918

Query: 364  SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
            +A+G P P I WT+     LP      I  SG + I       +G Y C A N   S H 
Sbjct: 3919 TASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHR 3978

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD-RRHLVL 482
               + V   P     P +  VI    +   CEA G P P I W K G  ++   R H VL
Sbjct: 3979 HVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVL 4038

Query: 483  SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANV 542
             SG L+IS     D G Y C A N  G+      L VQ  V PV +    +  + V   +
Sbjct: 4039 PSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQ--VPPVISPHLKEYVIAVDKPI 4096

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
             L C + G P P ITW+KDG  + ES +  +   G L I  V P DAG Y C+A N  GS
Sbjct: 4097 TLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS 4156

Query: 603  ASVSMVLSVNVP 614
            +S S  L+V+VP
Sbjct: 4157 SSTSTKLTVHVP 4168



 Score =  177 bits (450), Expect = 5e-44
 Identities = 121/399 (30%), Positives = 184/399 (46%), Gaps = 15/399 (3%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
            P    EP D  +  G+ V   C  +G P+P I W R +N          S ++ L  G L
Sbjct: 793  PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGAL 852

Query: 303  MIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLE 362
             I N   +D+G Y C A+N  G++++ E T+   G  A P   I P    V+ G+ +TL 
Sbjct: 853  FILNLWASDKGTYICEAENQFGKIQS-ETTVTVTGLVA-PLIGISPSVANVIEGQQLTLP 910

Query: 363  CSA-TGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            C+   G+P P   W +     L  +P + +   G L+I+ V   D GEY C A+N   + 
Sbjct: 911  CTLLAGNPIPERRWIKNSAMLLQ-NPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTN 969

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHL 480
            + T  ++V  LP      Q    IEG  V   C+A GNP P + W+K G  +S    +  
Sbjct: 970  NKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFS 1029

Query: 481  VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLT--VQPRVTPVFASIPSDTTVEV 538
              + G+L +      + G+Y C A N  G  K    LT  V+PRV      +  D  VE+
Sbjct: 1030 AGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEI 1089

Query: 539  ----GANVQLPCSSQGEPEPAITWNKDGVQVTESGKFH-ISPEGFLTINDVGPADAGRYE 593
                G  V LPC  +  P P ITW K+   ++     H   P G + I +   +D+G Y 
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYL 1149

Query: 594  CVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAI 632
            CVA N  G+ + ++ L+V+VP   + G   +   + + +
Sbjct: 1150 CVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRV 1188



 Score =  173 bits (438), Expect = 1e-42
 Identities = 120/377 (31%), Positives = 178/377 (47%), Gaps = 13/377 (3%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I+       V   N V   C A G P P + WL++ + +S  ++    L     L + 
Sbjct: 2012 PSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALT 2071

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
            + Q +D G Y C+A N AGE K +++ LR +     P  + + QN  VL+ ++V L C +
Sbjct: 2072 SAQISDTGRYTCVAVNAAGE-KQRDIDLRVY---VPPNIMGEEQNVSVLISQAVELLCQS 2127

Query: 366  TGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHAT 424
               PPP ++W + D  PL   P ++I+ +   L I++    D+G Y C ATN        
Sbjct: 2128 DAIPPPTLTWLK-DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKN 2186

Query: 425  AFIIVQALPQFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR--RHL 480
              + +   P    + +     VIEG  +   CE+ G PPP + W K GS +  D   R  
Sbjct: 2187 YNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVR 2246

Query: 481  VLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV-FASIPSDTTVEV 538
            +LS G  L+IS     D   Y C A N+ G+ K   +L V  R T     S P++  V  
Sbjct: 2247 ILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTR 2306

Query: 539  GANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVAR 597
            G ++ L C  QG P P +TW KDG  + ++    I  EG  L + ++  +D GRY CVA 
Sbjct: 2307 GKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAV 2366

Query: 598  NTIGSASVSMVLSVNVP 614
            N  G       LSV+ P
Sbjct: 2367 NVAGMTDKKYDLSVHAP 2383



 Score =  170 bits (431), Expect = 8e-42
 Identities = 124/401 (30%), Positives = 183/401 (45%), Gaps = 18/401 (4%)

Query: 244  ERPRI--TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
            E P I  + E ++  V   N +  TC A G P P++ W+++   L  +TD    L     
Sbjct: 3525 EPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLP-QTDQVQTLGGGEV 3583

Query: 302  LMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTL 361
            L I   Q  D G Y C+A + AG+   +E  +R    P       +P++  VL    VTL
Sbjct: 3584 LRISTAQVEDTGRYTCLASSPAGD-DDKEYLVRVH-VPPNIAGTDEPRDITVLRNRQVTL 3641

Query: 362  ECSATGHPPPRISWTR-GDRTPLPVDPRVNITPSGGLYIQ--NVVQGDSGEYACSATNNI 418
            EC +   PPP I+W R G+R  L   PRV I  SGG Y+Q  N   GD+  Y C A+N  
Sbjct: 3642 ECKSDAVPPPVITWLRNGER--LQATPRVRIL-SGGRYLQINNADLGDTANYTCVASNIA 3698

Query: 419  DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR- 477
                    + V   P     PQ  V++  ++   +C A+G P P I W K G+ L+ +  
Sbjct: 3699 GKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758

Query: 478  RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVE 537
            R+ +L +G L I    + D G+Y C A N  G+ +    + +Q  V P  A  P++ TV 
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDR--RRIDLQVHVPPSIAPGPTNMTVI 3816

Query: 538  VGANVQLPCSSQGEPEPAITWNKDGVQVT---ESGKFHISPEGFLTINDVGPADAGRYEC 594
            V     L C + G P+P+I W K+G  +        + +   G L I      D   YEC
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876

Query: 595  VARNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIVEAIAT 634
               N  G    ++ L+V V P ++     F+ T    A+ T
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVIT 3917



 Score =  165 bits (418), Expect = 3e-40
 Identities = 106/375 (28%), Positives = 166/375 (44%), Gaps = 15/375 (4%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           E P +   P +  VT G     TC         + W RN+ ++ +   +R+  L + +L 
Sbjct: 518 EPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLE 577

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           +++ +  D G Y CM  +  G          +      P   + P+N     G  V++ C
Sbjct: 578 LKSVKFNDAGEYHCMVSSEGGSSAASV----FLTVQEPPKVTVMPKNQSFTGGSEVSIMC 633

Query: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
           SATG+P P+I+WT  D   +    R  +T  G L+I+N    D+G Y C A+N+  +   
Sbjct: 634 SATGYPKPKIAWTVNDMF-IVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQ 692

Query: 424 TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
            + +     P+  V   + +V  G     +C+  G PPP + W KG  +L      L++ 
Sbjct: 693 NSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPST-FLIID 751

Query: 484 S--GTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
              G L+I      D G Y C A+N  G  +    +T+     PVF   P+D ++E+G+N
Sbjct: 752 PLLGLLKIQETQDLDAGDYTCVAINEAG--RATGKITLDVGSPPVFIQEPADVSMEIGSN 809

Query: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISP-----EGFLTINDVGPADAGRYECVA 596
           V LPC  QG PEP I W +       S  F +S       G L I ++  +D G Y C A
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869

Query: 597 RNTIGSASVSMVLSV 611
            N  G       ++V
Sbjct: 870 ENQFGKIQSETTVTV 884



 Score =  165 bits (418), Expect = 3e-40
 Identities = 126/407 (30%), Positives = 183/407 (44%), Gaps = 23/407 (5%)

Query: 232  SVATITPEELNCE---RPRIT---SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE 285
            +VA    +E N +   RP IT   S P +  VT G ++   C  +G P P + W+++ + 
Sbjct: 2273 NVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHP 2332

Query: 286  LSMKTDSRLNLLDDG-TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L       + +LD+G  L ++N   +D G Y C+A NVAG +  ++  L     P+    
Sbjct: 2333 LIKAKG--VEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-MTDKKYDLSVHAPPSIIGN 2389

Query: 345  VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVV 403
               P+N  V+   SV+L C A+G P P I+W + D  P+ +   V I   G  L +    
Sbjct: 2390 HRSPENISVVEKNSVSLTCEASGIPLPSITWFK-DGWPVSLSNSVRILSGGRMLRLMQTT 2448

Query: 404  QGDSGEYACSATNNIDSVHATAFIIVQALPQFTV--TPQDRVVIEGQTVDFQCEAKGNPP 461
              D+G+Y C   N          + V   P      T +D  V E Q+V   CE  GNP 
Sbjct: 2449 MEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPV 2508

Query: 462  PVIAWTKGGSQLSVDRRHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ 520
            P I W K G  L  D  H ++S G  L+I+ V +   G+Y C A +  G +     L V 
Sbjct: 2509 PEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNV- 2567

Query: 521  PRVTPVFASI-----PSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISP 575
              V+P  A +     P D TV + +   L C +   P   ITW KDG  +  +    I P
Sbjct: 2568 -FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILP 2626

Query: 576  EG-FLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGD 621
             G  L I +    +AGRY CVA N  G       + V +P +   GD
Sbjct: 2627 GGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGD 2673



 Score =  162 bits (411), Expect = 2e-39
 Identities = 119/390 (30%), Positives = 173/390 (44%), Gaps = 16/390 (4%)

Query: 253  QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETD 311
            ++  V  G++    C  +G P P + WLR+   L +  D+ L +   G  L +   +  D
Sbjct: 3443 EEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGL--DAHLTVSTHGMVLQLLKAETED 3500

Query: 312  QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
             G Y C+A N AGEV ++   L+    P       + +   V+V   + L C A+G P P
Sbjct: 3501 SGKYTCIASNEAGEV-SKHFILKVL-EPPHINGSEEHEEISVIVNNPLELTCIASGIPAP 3558

Query: 372  RISWTRGDRTPLPVDPRVNITPSGG--LYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
            +++W + D  PLP   +V  T  GG  L I      D+G Y C A++          + V
Sbjct: 3559 KMTWMK-DGRPLPQTDQVQ-TLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRV 3616

Query: 430  QALPQFTVT--PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT- 486
               P    T  P+D  V+  + V  +C++   PPPVI W + G +L    R  +LS G  
Sbjct: 3617 HVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRY 3676

Query: 487  LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPC 546
            L+I+   L D   Y C A NI G  K      +   V P     P    + +  +  L C
Sbjct: 3677 LQINNADLGDTANYTCVASNIAG--KTTREFILTVNVPPNIKGGPQSLVILLNKSTVLEC 3734

Query: 547  SSQGEPEPAITWNKDG-VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASV 605
             ++G P P ITW KDG V      ++ I   GFL I      D GRY C+A N  G+   
Sbjct: 3735 IAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRR 3794

Query: 606  SMVLSVNVPDVSRNGDPFVATSIVEAIATV 635
             + L V+VP     G P   T IV    T+
Sbjct: 3795 RIDLQVHVPPSIAPG-PTNMTVIVNVQTTL 3823



 Score =  160 bits (405), Expect = 8e-39
 Identities = 129/412 (31%), Positives = 198/412 (48%), Gaps = 36/412 (8%)

Query: 248  ITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNT 307
            I  + ++  V   N +  TC   G P P++ WL+N   + + T++ L +    TL I   
Sbjct: 2967 IGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNT-LIVPGGRTLQIIRA 3025

Query: 308  QETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV------GESVTL 361
            + +D G Y C+A N AGE K ++ +L  +  P+     I+  ++E L       G SV+L
Sbjct: 3026 KVSDGGEYTCIAINQAGESK-KKFSLTVYVPPS-----IKDHDSESLSVVNVREGTSVSL 3079

Query: 362  ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDS 420
            EC +   PPP I+W +  R  +     V I   G  L+I+     D+G+Y C A N +  
Sbjct: 3080 ECESNAVPPPVITWYKNGRM-ITESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAG 3137

Query: 421  VHATAFIIVQALPQFTVTPQDRVVIE--GQTVDFQCEAKGNPPPVIAWTKGGSQL----S 474
                 F +   +P     P+  V++E     V   C+A G PPP IAW K   ++    S
Sbjct: 3138 RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDS 3197

Query: 475  VDRRHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSD 533
            ++ R  +LS G+ L+I+     D G Y C A N+ G  +    L++Q   +   A IPSD
Sbjct: 3198 LEVR--ILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSD 3255

Query: 534  TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT--ESGKFHISPEGFLTINDVG--PADA 589
             +V +G NV+L C++ G P P I W KDG  +   E+ +  +S  G  T+N  G   +D 
Sbjct: 3256 VSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANG-STLNIYGALTSDT 3314

Query: 590  GRYECVARNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIVEAIATVDRAIN 640
            G+Y CVA N  G       L+V V P +  N D        + +  VD +IN
Sbjct: 3315 GKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKD-----EAEKLMTLVDTSIN 3361



 Score =  159 bits (401), Expect = 2e-38
 Identities = 113/372 (30%), Positives = 160/372 (43%), Gaps = 10/372 (2%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I+   ++  +     +  +C A+G P P+I W ++    ++    R  +L  G+L I 
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGR--AIVESIRQRVLSSGSLQIA 4136

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
              Q  D G Y CMA NVAG   T      +     R T      +  V       L C A
Sbjct: 4137 FVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRST----EGHYTVNENSQAILPCVA 4192

Query: 366  TGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
             G P P I+W + +     +  +    P G L ++NVV  DSG Y C A N       T 
Sbjct: 4193 DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTV 4252

Query: 426  FIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG 485
             + V  LP FT  P D  + +G+ +   C+A G P P + WT   + +       V    
Sbjct: 4253 SLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPA-HFDSVNGHS 4311

Query: 486  TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVF-ASIPSDTTVEVGANVQL 544
             L I  V+  D G Y C A N +G  K +  + V+    PVF    PS+    +G N  L
Sbjct: 4312 ELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE--PPVFKGDYPSNWIEPLGGNAIL 4369

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
             C  +G+P P I WN+ GV +  S +      G L I      DAG Y CVA N  G   
Sbjct: 4370 NCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE 4429

Query: 605  VSMVLSVNVPDV 616
             SM L++  P +
Sbjct: 4430 RSMSLTLQSPPI 4441



 Score =  158 bits (400), Expect = 3e-38
 Identities = 118/390 (30%), Positives = 166/390 (42%), Gaps = 35/390 (8%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
            P+D  V   +     C A   P   I W ++   L    + R+ L    TL I N QE +
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRI-LPGGRTLQILNAQEDN 2640

Query: 312  QGIYQCMAKNVAGE-VKTQEVTLRYFGSPARPTFV---------IQPQNTEVLVGESVTL 361
             G Y C+A N AGE +K  EV +        P  +         + P+  ++ V  ++TL
Sbjct: 2641 AGRYSCVATNEAGEMIKHYEVKVYI------PPIINKGDLWGPGLSPKEVKIKVNNTLTL 2694

Query: 362  ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSG-GLYIQNVVQGDSGEYACSATNNIDS 420
            EC A   P   +SW + D  PL  D  VNI  +G  L I+     D+G Y C A+N    
Sbjct: 2695 ECEAYAIPSASLSWYK-DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGE 2753

Query: 421  VHATAFIIVQALPQFTV------------TPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK 468
                  + +Q  P F                + + VI    +   CE    PPP + W K
Sbjct: 2754 DELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK 2813

Query: 469  GGSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQAVNIIG--SQKVVAHLTVQPRVTP 525
             G  L+   + L+L  G  L+I    + D G+Y C AVN  G  S +    + V P +  
Sbjct: 2814 DGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKG 2873

Query: 526  VFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDV 584
              + +P + TV V  +  + C S G P P  +W KDG  + E         G  L I + 
Sbjct: 2874 ANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNT 2933

Query: 585  GPADAGRYECVARNTIGSASVSMVLSVNVP 614
               D GRY CVA NT GSA     L+V+VP
Sbjct: 2934 QITDIGRYVCVAENTAGSAKKYFNLNVHVP 2963



 Score =  157 bits (397), Expect = 7e-38
 Identities = 110/402 (27%), Positives = 183/402 (45%), Gaps = 30/402 (7%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P+I   P+   V  G  V   C A+G P P I W +  + + +  +  ++   DGTL I 
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN-PDGTLSID 1229

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNT---EVLVGESVTLE 362
                +D GIY C+A N+AG  +T E+TL +   P     +  P NT   E +  + +   
Sbjct: 1230 QATPSDAGIYTCVATNIAGTDET-EITL-HVQEPPTVEDLEPPYNTTFQERVANQRIEFP 1287

Query: 363  CSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSV 421
            C A G P P I W    R     +P ++I   G L  I +V   D+GEY C A N   + 
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTT 1347

Query: 422  HATAFIIVQALPQFTVTPQDRV----VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR 477
                 + V   P   +  +++V    V+  Q  +  CE +G P P+I W K   Q++   
Sbjct: 1348 ERKYNLKVHVPP--VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESS 1405

Query: 478  RHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV 536
                +++G  L++      D G+Y C+A+NI G+ +   ++ V    T +  + P++ +V
Sbjct: 1406 TIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSV 1465

Query: 537  EVGANVQLPCSSQGEPEPAITWNKDG---------VQVTESGKFHISPEGFLTINDVGPA 587
             +  +V L C  +G P P I W KDG         V++ + G+        L + +    
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQV-------LHLKNARRN 1518

Query: 588  DAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIV 629
            D GRY+C   N  G  +  + L++ +P   + G+     S++
Sbjct: 1519 DKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVL 1560



 Score =  155 bits (393), Expect = 2e-37
 Identities = 114/383 (29%), Positives = 160/383 (41%), Gaps = 16/383 (4%)

Query: 244  ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLN-LLDDGTL 302
            E P I  +P +  V   N +   C A G P P I W +    +++ T  R + +L  G L
Sbjct: 3986 EPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEG--INVNTSGRNHAVLPSGGL 4043

Query: 303  MIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE--VLVGESVT 360
             I      D G Y C+A+N AG     ++ L     P     VI P   E  + V + +T
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAG-TALGKIKLNVQVPP-----VISPHLKEYVIAVDKPIT 4097

Query: 361  LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420
            L C A G PPP I+W +  R  +    R  +  SG L I  V  GD+G Y C A N   S
Sbjct: 4098 LSCEADGLPPPDITWHKDGRA-IVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGS 4156

Query: 421  VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL-SVDRRH 479
               +  + V   P+   T     V E       C A G P P I W K    L ++  ++
Sbjct: 4157 SSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKY 4216

Query: 480  LVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVG 539
                 G L +  V L D G Y C A N  G       LTV   V P F  +P D ++  G
Sbjct: 4217 TAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV--HVLPTFTELPGDVSLNKG 4274

Query: 540  ANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNT 599
              ++L C + G P P +TW  +   +  +    ++    L I  V   D+G Y C A N+
Sbjct: 4275 EQLRLSCKATGIPLPKLTWTFNN-NIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENS 4333

Query: 600  IGSASVSMVLSVNVPDVSRNGDP 622
            +G       + V  P V +   P
Sbjct: 4334 VGFVKAIGFVYVKEPPVFKGDYP 4356



 Score =  155 bits (391), Expect = 4e-37
 Identities = 122/406 (30%), Positives = 180/406 (44%), Gaps = 19/406 (4%)

Query: 257  VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
            V   N +   C   G+P P I+WL++   +  +   ++ LL+   L+I   Q ++ G+Y+
Sbjct: 1746 VMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI-LLNGRKLVIAQAQVSNTGLYR 1804

Query: 317  CMAKNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVG-ESVTLECSATGHPPPRIS 374
            CMA N AG+ K + EVT+        PT      +  V+V  + V L+C A G P P I+
Sbjct: 1805 CMAANTAGDHKKEFEVTVH-----VPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSIT 1859

Query: 375  WTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALP 433
            W + D+        + I  SG  L I   +  D+G Y C ATN          + V   P
Sbjct: 1860 WLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPP 1919

Query: 434  QFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTL-RIS 490
                  +  +  V+    V  +C+A GNP PVI W K    LS       L+ G +  I 
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIE 1979

Query: 491  GVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQG 550
               + D G Y+C A+N  G+ ++   L V   V P  +   +   V V   V+L C ++G
Sbjct: 1980 SAQISDAGIYKCVAINSAGATELFYSLQVH--VAPSISGSNNMVAVVVNNPVRLECEARG 2037

Query: 551  EPEPAITWNKDGVQVTE--SGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMV 608
             P P++TW KDG  V+   +G   +S    L +     +D GRY CVA N  G     + 
Sbjct: 2038 IPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDID 2097

Query: 609  LSVNVPDVSRNGDPFVATSI---VEAIATVDRAINSTRTHLFDSRP 651
            L V VP      +  V+  I   VE +   D     T T L D  P
Sbjct: 2098 LRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHP 2143



 Score =  149 bits (375), Expect = 3e-35
 Identities = 112/366 (30%), Positives = 157/366 (42%), Gaps = 10/366 (2%)

Query: 256  DVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIY 315
            DV   N +   C     P P + W ++ + L+  +D  L L     L I   +  D G Y
Sbjct: 2788 DVIINNPISLYCETNAAPPPTLTWYKDGHPLT-SSDKVLILPGGRVLQIPRAKVEDAGRY 2846

Query: 316  QCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISW 375
             C+A N AGE   Q           +      P+   VLV +S  +EC ++G P PR SW
Sbjct: 2847 TCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSW 2906

Query: 376  TRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
             + D  PL  D       +G  L I N    D G Y C A N   S     F +   +P 
Sbjct: 2907 QK-DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSA-KKYFNLNVHVPP 2964

Query: 435  FTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG-TLRISG 491
              + P  ++  V+    +   CE  G PPP ++W K    + ++   L++  G TL+I  
Sbjct: 2965 SVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIR 3024

Query: 492  VALHDQGQYECQAVNIIGSQKVVAHLT--VQPRVTPVFASIPSDTTVEVGANVQLPCSSQ 549
              + D G+Y C A+N  G  K    LT  V P +    +   S   V  G +V L C S 
Sbjct: 3025 AKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESN 3084

Query: 550  GEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSMV 608
              P P ITW K+G  +TES    I  +G  L I     +D G+Y C A N  G    +  
Sbjct: 3085 AVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFH 3144

Query: 609  LSVNVP 614
            L+V VP
Sbjct: 3145 LNVYVP 3150



 Score =  147 bits (370), Expect = 1e-34
 Identities = 103/371 (27%), Positives = 165/371 (44%), Gaps = 12/371 (3%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQET 310
            P D  V  G  V   C A G P P I WL++   ++     R+ +  +G TL I     +
Sbjct: 3253 PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTS 3312

Query: 311  DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370
            D G Y C+A N AGE + +   L  + +P       + +    LV  S+ +EC ATG PP
Sbjct: 3313 DTGKYTCVATNPAGE-EDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPP 3371

Query: 371  PRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN--NIDSVHATAFI 427
            P+I+W + +  PLP+   + +  +G  + I      D   Y C A+N   +D+ H    +
Sbjct: 3372 PQINWLK-NGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQV 3430

Query: 428  IVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG-T 486
                    ++  ++  V++G +    C   G P P +AW + G  L +D    V + G  
Sbjct: 3431 FAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV 3490

Query: 487  LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN--VQL 544
            L++      D G+Y C A N  G  +V  H  ++    P          + V  N  ++L
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEAG--EVSKHFILKVLEPPHINGSEEHEEISVIVNNPLEL 3548

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSA 603
             C + G P P +TW KDG  + ++ +      G  L I+     D GRY C+A +  G  
Sbjct: 3549 TCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD 3608

Query: 604  SVSMVLSVNVP 614
                ++ V+VP
Sbjct: 3609 DKEYLVRVHVP 3619



 Score =  146 bits (368), Expect = 2e-34
 Identities = 108/372 (29%), Positives = 158/372 (42%), Gaps = 9/372 (2%)

Query: 263  VYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETDQGIYQCMAKN 321
            V   C A G P P I WL+++  ++      L +   G  L I  T   D G Y C+A N
Sbjct: 1844 VALQCIANGIPNPSITWLKDDQPVNT-AQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902

Query: 322  VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381
             AGE  TQ+    +   P       +  N  VLV   V LEC A G+P P I+W + +R 
Sbjct: 1903 AAGE--TQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRL 1960

Query: 382  PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQD 441
                     +     + I++    D+G Y C A N+  +      + V   P  + +   
Sbjct: 1961 LSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNM 2020

Query: 442  RVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG--TLRISGVALHDQGQ 499
              V+    V  +CEA+G P P + W K GS +S     L + SG   L ++   + D G+
Sbjct: 2021 VAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR 2080

Query: 500  YECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWN 559
            Y C AVN  G ++    L V   V P       + +V +   V+L C S   P P +TW 
Sbjct: 2081 YTCVAVNAAGEKQRDIDLRVY--VPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWL 2138

Query: 560  KDGVQVTESGKFHISP-EGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSR 618
            KDG  + +     IS     L I D    D GRY C A N  G    +  +++ VP    
Sbjct: 2139 KDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIG 2198

Query: 619  NGDPFVATSIVE 630
              D     +++E
Sbjct: 2199 GSDELTQLTVIE 2210



 Score =  145 bits (366), Expect = 3e-34
 Identities = 101/335 (30%), Positives = 148/335 (44%), Gaps = 8/335 (2%)

Query: 284 NELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPT 343
           N +++  D  L       L I     +D+G Y+C+A + AG  + Q     +F     P 
Sbjct: 466 NGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQT----FFDVSEPPP 521

Query: 344 FVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDP-RVNITPSGGLYIQNV 402
            +  P N  V  GE   L C         ++W R DR     +P R+    +  L +++V
Sbjct: 522 VIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSV 581

Query: 403 VQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPP 462
              D+GEY C  ++   S  A+ F+ VQ  P+ TV P+++    G  V   C A G P P
Sbjct: 582 KFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKP 641

Query: 463 VIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPR 522
            IAWT     +    R+ + S GTL I   A  D G Y C A N  G+ K   + T++  
Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDK--QNSTLRYI 699

Query: 523 VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISP-EGFLTI 581
             P    + S+  V +G    + C + G P P + W K  +++  S    I P  G L I
Sbjct: 700 EAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKI 759

Query: 582 NDVGPADAGRYECVARNTIGSASVSMVLSVNVPDV 616
            +    DAG Y CVA N  G A+  + L V  P V
Sbjct: 760 QETQDLDAGDYTCVAINEAGRATGKITLDVGSPPV 794



 Score =  145 bits (365), Expect = 4e-34
 Identities = 99/372 (26%), Positives = 163/372 (43%), Gaps = 9/372 (2%)

Query: 249  TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNT 307
            T+ P +  V     V   C+ +G P P+I W ++   L +  D  + LLD G ++ ++N 
Sbjct: 1457 TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNA 1515

Query: 308  QETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATG 367
            +  D+G YQC   N AG+ + +++ L  +  P+     +   +  VL+   + LEC   G
Sbjct: 1516 RRNDKGRYQCTVSNAAGK-QAKDIKLTIYIPPSIKGGNVTT-DISVLINSLIKLECETRG 1573

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFI 427
             P P I+W +  +  +     + I     L+I      DS  Y C   N   +   +  +
Sbjct: 1574 LPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHV 1633

Query: 428  IVQALPQFT---VTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSS 484
             V   P       TP ++ V+   ++  +C+A GNP P++ W K G  +  +    + + 
Sbjct: 1634 DVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAG 1693

Query: 485  G-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
            G  L I      D+GQY C A ++ G +++   + V            S   V V   ++
Sbjct: 1694 GKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLE 1753

Query: 544  LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGS 602
            L C   G P P I W KDG  + E   F I   G  L I     ++ G Y C+A NT G 
Sbjct: 1754 LDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD 1813

Query: 603  ASVSMVLSVNVP 614
                  ++V+VP
Sbjct: 1814 HKKEFEVTVHVP 1825



 Score =  142 bits (358), Expect = 2e-33
 Identities = 107/359 (29%), Positives = 165/359 (45%), Gaps = 11/359 (3%)

Query: 263  VYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNTQETDQGIYQCMAKN 321
            + F C A+G PKP I WL N  EL+ + +  +++L+DGTL+ I +    D G Y C+A N
Sbjct: 1284 IEFPCPAKGTPKPTIKWLHNGRELTGR-EPGISILEDGTLLVIASVTPYDNGEYICVAVN 1342

Query: 322  VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381
             AG  + ++  L+    P       Q  N  VL+ +   L C   G P P I W + D  
Sbjct: 1343 EAGTTE-RKYNLKVHVPPVIKDKE-QVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK-DNV 1399

Query: 382  PLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVT-- 438
             +     +    +G  L +      D+G Y+C A N   +      I V   P    T  
Sbjct: 1400 QVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNF 1459

Query: 439  PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHLVLSSG-TLRISGVALHD 496
            P +  V+  + V  +C+ KG P P I W K G  L + D    +L  G  L +     +D
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRND 1519

Query: 497  QGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAI 556
            +G+Y+C   N  G Q     LT+    +    ++ +D +V + + ++L C ++G P PAI
Sbjct: 1520 KGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAI 1579

Query: 557  TWNKDGVQVTESGK-FHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            TW KDG  +  S +  +I    +L I     +D+  Y C   N  G+A  S  + V VP
Sbjct: 1580 TWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVP 1638



 Score =  140 bits (354), Expect = 7e-33
 Identities = 100/367 (27%), Positives = 155/367 (42%), Gaps = 21/367 (5%)

Query: 267  CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNTQETDQGIYQCMAKNVAGE 325
            C  EG P P I+W ++N +++    S +  +++G ++ +      D G Y C A N+AG 
Sbjct: 1382 CEVEGTPSPIIMWYKDNVQVT--ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAG- 1438

Query: 326  VKTQEVTLRYFGSPAR--PTFVIQ--PQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381
                  + +YF       PT +    P    V++   V LEC   G P P I W +  + 
Sbjct: 1439 -----TSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP 1493

Query: 382  PLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF---TV 437
                DP V +   G  L+++N  + D G Y C+ +N          + +   P      V
Sbjct: 1494 LFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNV 1553

Query: 438  TPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-LRISGVALHD 496
            T    V+I    +  +CE +G P P I W K G  +    + L +  G  L I    + D
Sbjct: 1554 TTDISVLINS-LIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSD 1612

Query: 497  QGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555
               Y C   N+ G+ +   H+ V  P +     + P +  V +  ++ L C + G P P 
Sbjct: 1613 SATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI 1672

Query: 556  ITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            +TW KDGV V  +    I   G  L I      D G+Y CVA +  G   +   + V VP
Sbjct: 1673 LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVP 1732

Query: 615  DVSRNGD 621
                 GD
Sbjct: 1733 PAIEGGD 1739



 Score =  140 bits (353), Expect = 9e-33
 Identities = 110/376 (29%), Positives = 168/376 (44%), Gaps = 18/376 (4%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMIQNTQET 310
            P +  V   +++   C+A GNP P + WL++   + +K +  + +   G  L I + QE 
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPILTWLKDG--VPVKANDNIRIEAGGKKLEIMSAQEI 1705

Query: 311  DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE---VLVGESVTLECSATG 367
            D+G Y C+A +VAGE +     ++Y      P  +     T    V+V   + L+C  TG
Sbjct: 1706 DRGQYICVATSVAGEKE-----IKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTG 1760

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFI 427
             PPP I W +  +     D    +     L I      ++G Y C A N     H   F 
Sbjct: 1761 SPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD-HKKEFE 1819

Query: 428  IVQALPQFTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG 485
            +   +P    +    +RVV++ + V  QC A G P P I W K    ++  + +L + S 
Sbjct: 1820 VTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSS 1879

Query: 486  --TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
               L+I+   L D G+Y C A N  G  +    L V    +   A    + TV V   VQ
Sbjct: 1880 GRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQ 1939

Query: 544  LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGS 602
            L C + G P P ITW KD   ++ S        G  + I     +DAG Y+CVA N+ G+
Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999

Query: 603  ASVSMVLSVNV-PDVS 617
              +   L V+V P +S
Sbjct: 2000 TELFYSLQVHVAPSIS 2015



 Score =  139 bits (350), Expect = 2e-32
 Identities = 111/387 (28%), Positives = 176/387 (45%), Gaps = 22/387 (5%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQET 310
            P++  +   NT+   C A   P   + W ++   L  K+D  +N+  +G TL I+  Q +
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPL--KSDDHVNIAANGHTLQIKEAQIS 2738

Query: 311  DQGIYQCMAKNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNT-------EVLVGESVTLE 362
            D G Y C+A N+AGE +   +V ++   S  +   +    +T       +V++   ++L 
Sbjct: 2739 DTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY 2798

Query: 363  CSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI--D 419
            C     PPP ++W + D  PL    +V I P G  L I      D+G Y C A N    D
Sbjct: 2799 CETNAAPPPTLTWYK-DGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGED 2857

Query: 420  SVHATAFIIVQALPQFTVT--PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDR 477
            S+     ++V  + +   +  P++  V+  ++   +C + G+P P  +W K G  L  D 
Sbjct: 2858 SLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDD 2917

Query: 478  RHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP-VFASIPSDTT 535
             H  LS+G  L+I    + D G+Y C A N  GS K   +L V   V P V      + T
Sbjct: 2918 HHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNV--HVPPSVIGPKSENLT 2975

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYEC 594
            V V   + L C   G P P ++W K+   +  +    I P G  L I     +D G Y C
Sbjct: 2976 VVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTC 3035

Query: 595  VARNTIGSASVSMVLSVNVPDVSRNGD 621
            +A N  G +     L+V VP   ++ D
Sbjct: 3036 IAINQAGESKKKFSLTVYVPPSIKDHD 3062



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 4/163 (2%)

Query: 454 CEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513
           C      P  +++ + G  L VD+     +S  L I+ V L D+G YEC AV+  G+ + 
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRA 510

Query: 514 VAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITW--NKDGVQVTESGKF 571
                V     P    +P++ TV  G    L C      +  +TW  N   V++ E  + 
Sbjct: 511 QTFFDVSE--PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARI 568

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
                  L +  V   DAG Y C+  +  GS++ S+ L+V  P
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEP 611



 Score = 33.5 bits (75), Expect = 1.6
 Identities = 31/130 (23%), Positives = 53/130 (40%), Gaps = 15/130 (11%)

Query: 487 LRISGVALHDQGQYECQAVNIIGSQKVV--AHLTVQPRVTPVFASIPSDTTVEVGANVQL 544
           L+++G   +D+  Y  Q V+ +    +V  A     P  TP +   P           Q+
Sbjct: 403 LKVTG---YDKDDYLFQRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPG----------QI 449

Query: 545 PCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
           PCS        +++ ++GV +        S    L I  V  +D G YEC+A ++ G+  
Sbjct: 450 PCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGR 509

Query: 605 VSMVLSVNVP 614
                 V+ P
Sbjct: 510 AQTFFDVSEP 519


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  199 bits (507), Expect = 1e-50
 Identities = 130/395 (32%), Positives = 191/395 (48%), Gaps = 21/395 (5%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTC-RAEGNPKPEIIWLRNNN 284
           R   G + +     E+   R      P +  V  G      C    G+P+P + W ++  
Sbjct: 146 RNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGA 205

Query: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
            L  + + R+ +   G LM+ +T ++D G+Y C+A N+AGE ++    +       RP+F
Sbjct: 206 RLK-EEEGRITIRG-GKLMMSHTLKSDAGMYVCVASNMAGERESAAAEVMVL---ERPSF 260

Query: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
           + +P N  VL    VT  C   G PPPR+ W + D   LP   R  I     L+I +V  
Sbjct: 261 LRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGE-LPTG-RYEIRSDHSLWIGHVSA 318

Query: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
            D G Y C A N++    A+  + V   PQ    PQD++   G++V FQCE KGNPPP I
Sbjct: 319 EDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAI 378

Query: 465 AWTKGGSQ--------LSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
            W K GSQ        L    R  V   G L I+ V   D G Y CQAV++ GS    A 
Sbjct: 379 FWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL 438

Query: 517 LTVQ----PRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVT-ESGKF 571
           L ++      + PV    P++ T+ +G++V LPC   G P+P++ W KDG  +  +  +F
Sbjct: 439 LEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQF 498

Query: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVS 606
                G L I +V   D G Y CVA+++ G A+ S
Sbjct: 499 KTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533



 Score =  193 bits (490), Expect = 1e-48
 Identities = 126/384 (32%), Positives = 181/384 (47%), Gaps = 24/384 (6%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNEL-SMKTDSRLN--LLDDGTL 302
           PRI  +P D  V+ G      CRAEG P+P I W +N   + +++ D R +  LL  G L
Sbjct: 64  PRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGAL 123

Query: 303 MIQ-----NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
                        D+G+Y C+A+N  G   ++  +L    +  R  F   P N  V VGE
Sbjct: 124 FFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEV--AVLRDDFRQSPGNVVVAVGE 181

Query: 358 SVTLEC-SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
              LEC    GHP P +SW +        + R+ I   G L + + ++ D+G Y C A+N
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLMMSHTLKSDAGMYVCVASN 240

Query: 417 NI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
              +   A A ++V   P F   P ++VV+    V F CE KG+PPP + W K   +L  
Sbjct: 241 MAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELPT 300

Query: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
             R+ + S  +L I  V+  D+G Y C A N +G  +    L+V   V P   + P D  
Sbjct: 301 G-RYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSV--HVPPQLVTQPQDQM 357

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQV--------TESGKFHISPEGFLTINDVGPA 587
              G +V   C ++G P PAI W K+G QV          +G+F +SP G L I  V   
Sbjct: 358 AAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRG 417

Query: 588 DAGRYECVARNTIGSASVSMVLSV 611
           DAG Y C A +  GS     +L +
Sbjct: 418 DAGYYVCQAVSVAGSILAKALLEI 441



 Score =  135 bits (340), Expect = 3e-31
 Identities = 93/287 (32%), Positives = 134/287 (46%), Gaps = 14/287 (4%)

Query: 340 ARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVN--ITPSG 395
           A P  V QP +  V  GE  TL C A G P P I W +       V  DPR +  + PSG
Sbjct: 62  AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSG 121

Query: 396 GLYIQNVVQG-----DSGEYACSATNNIDSVHA-TAFIIVQAL-PQFTVTPQDRVVIEGQ 448
            L+   +V G     D G Y C A N + +  +  A + V  L   F  +P + VV  G+
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGE 181

Query: 449 TVDFQC-EAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNI 507
               +C   +G+P P ++W K G++L  +   + +  G L +S     D G Y C A N+
Sbjct: 182 PAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGMYVCVASNM 241

Query: 508 IGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE 567
            G ++  A   V     P F   P +  V   A V   C  +G+P P + W K+  ++  
Sbjct: 242 AGERESAA-AEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRKEDGELP- 299

Query: 568 SGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
           +G++ I  +  L I  V   D G Y CVA N++G A  S  LSV+VP
Sbjct: 300 TGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVP 346


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  195 bits (495), Expect = 3e-49
 Identities = 127/379 (33%), Positives = 174/379 (45%), Gaps = 16/379 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE-----LSMKTDSRLNLLDDG 300
            P++T  P+D  V  G +    CRA G P P + W R + +     L     SR    D G
Sbjct: 669  PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 728

Query: 301  TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
             L  ++    DQ  Y C A+NV G+V+  E  L   G  A P          VL G+ V+
Sbjct: 729  VLFFESVAPEDQAPYVCEARNVFGKVQA-EARLIVTGH-APPQIASSAPTVRVLEGQPVS 786

Query: 361  LECSA-TGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID 419
            L C    G P P   W +  R PLP   R +I   G L++   +Q  +G Y+C ATN   
Sbjct: 787  LPCIVLAGRPLPERHWLKDGR-PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 845

Query: 420  SVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRH 479
            S H    ++VQ  P+   T    +  EG      C A G P P I WTK  + L+    H
Sbjct: 846  SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 905

Query: 480  L-VLSSGTLRISGVALHDQGQYECQAVNIIG--SQKVVAHLTVQPRV---TPVFASIPSD 533
              V   GTL I+  +  D G Y C A N +G  SQ++   +  +PR+       A++P  
Sbjct: 906  YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQ 965

Query: 534  TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTE-SGKFHISPEGFLTINDVGPADAGRY 592
             T + G  V L C ++G P P +TW KD   V   + ++ + P G L +  V   D+G Y
Sbjct: 966  VTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHY 1025

Query: 593  ECVARNTIGSASVSMVLSV 611
            EC A N  GSAS   VL V
Sbjct: 1026 ECTASNPAGSASHRYVLGV 1044



 Score =  187 bits (475), Expect = 6e-47
 Identities = 154/493 (31%), Positives = 203/493 (41%), Gaps = 44/493 (8%)

Query: 257  VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
            V  G      C A G P P +IW R   E+ +  +        G L I   QE D G Y 
Sbjct: 592  VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYT 647

Query: 317  CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWT 376
            C A N  G+    E+ L    +P        P++  V +G S  L C ATG PPP ++W 
Sbjct: 648  CRAVNELGDASA-EIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPPTVTWR 703

Query: 377  RGDRTPLPV------DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV- 429
            RGD  PL +        R     SG L+ ++V   D   Y C A N    V A A +IV 
Sbjct: 704  RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 763

Query: 430  -QALPQFTVTPQDRVVIEGQTVDFQCEA-KGNPPPVIAWTKGGSQLSVDRRHLVLSSGTL 487
              A PQ   +     V+EGQ V   C    G P P   W K G  L    RH + + G+L
Sbjct: 764  GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 823

Query: 488  RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ--PRVTPVFASIPSDTTVEVGANVQLP 545
             +        G+Y C A N  GSQ     L VQ  PR+ P      +      G    LP
Sbjct: 824  HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPT----ATHHITNEGVPASLP 879

Query: 546  CSSQGEPEPAITWNKDGVQVTESGK-FHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
            C + G P P ITW K+   +T  G  +++S EG L I      DAG Y C A NT+G +S
Sbjct: 880  CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939

Query: 605  VSMVLSVNV-PDVSRNGD-----PFVATSIVEAIATVDRAINSTRTHLF----DSRPRSP 654
              M LSVN  P +  NG      P   T+      T+D     +   L     DSRP  P
Sbjct: 940  QEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPP 999

Query: 655  NDLLALFRY---PRDPYTVEQARAGEI--FERTLQLIQEHVQHGLMVDLNG-TSYHYNDL 708
                   RY   P     + Q + G+   +E T         H  ++ + G TS+    L
Sbjct: 1000 ----ITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSL 1055

Query: 709  VSPQYLNLIANLS 721
              P +   ++ LS
Sbjct: 1056 PVPHHPACLSGLS 1068



 Score =  184 bits (466), Expect = 7e-46
 Identities = 131/381 (34%), Positives = 168/381 (44%), Gaps = 21/381 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           E P+++        + G  V  +C A G P P I W R +  L  + DSR+++   GTL+
Sbjct: 489 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL--QEDSRIHVDAQGTLI 546

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV--GESVTL 361
           IQ     D G Y C A N  G    + VTL Y   P+     +   N  VLV  GE   L
Sbjct: 547 IQGVAPEDAGNYSCQATNEVG-TDQETVTLYYTDPPS-----VSAVNAVVLVAVGEEAVL 600

Query: 362 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            C A+G PPPR+ W RG    L +      + SG L I    + D+G Y C A N +   
Sbjct: 601 VCEASGVPPPRVIWYRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 657

Query: 422 HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG-----GSQLSVD 476
            A   + V   PQ T  P+D  V  G++    C A G PPP + W +G     G +L   
Sbjct: 658 SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAG 717

Query: 477 R--RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
           R  R     SG L    VA  DQ  Y C+A N+ G  +  A L V     P  AS     
Sbjct: 718 RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 777

Query: 535 TVEVGANVQLPC-SSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYE 593
            V  G  V LPC    G P P   W KDG  +    +  I  +G L ++      AGRY 
Sbjct: 778 RVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYS 837

Query: 594 CVARNTIGSASVSMVLSVNVP 614
           CVA NT GS    + L V VP
Sbjct: 838 CVATNTAGSQHRDVELVVQVP 858



 Score =  170 bits (430), Expect = 1e-41
 Identities = 126/424 (29%), Positives = 178/424 (41%), Gaps = 28/424 (6%)

Query: 211 AESGNAQAAAICEYPR-RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA 269
           AE G  +  A+      R + + V T  P +L    P +T  P       G T   +CR 
Sbjct: 372 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSP-------GETAVLSCRV 423

Query: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
            G     + W+R+   L   T  R+  L D +L I     TD G YQC+A N  G  +  
Sbjct: 424 LGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 482

Query: 330 EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRV 389
              L        P   I   +     G  V + CSA+G+P P ISW+R +   L  D R+
Sbjct: 483 VWLL----VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQEDSRI 537

Query: 390 NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449
           ++   G L IQ V   D+G Y+C ATN + +   T  +     P  +      +V  G+ 
Sbjct: 538 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 597

Query: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
               CEA G PPP + W +GG ++ +       SSG LRI      D G Y C+AVN +G
Sbjct: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 655

Query: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DG------ 562
                  L V     P    +P D TVE+G +  L C + G P P +TW + DG      
Sbjct: 656 DASAEIQLAVGH--APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 713

Query: 563 VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG--SASVSMVLSVNVPDVSRNG 620
           +      +      G L    V P D   Y C ARN  G   A   ++++ + P    + 
Sbjct: 714 LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS 773

Query: 621 DPFV 624
            P V
Sbjct: 774 APTV 777



 Score =  138 bits (347), Expect = 5e-32
 Identities = 96/310 (30%), Positives = 139/310 (44%), Gaps = 12/310 (3%)

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I    + ++G Y+C A + AG   T     +   +   P  V  P N  V  GE+  L C
Sbjct: 366 ILRASKAEEGTYECTAVSRAG---TGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSC 421

Query: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
              G  P  ++W R  R       RV       L I  ++  D G Y C A+N      A
Sbjct: 422 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 481

Query: 424 TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
           + +++V+  PQ ++    +   +G  V   C A G P P I+W++    L  D R  V +
Sbjct: 482 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 541

Query: 484 SGTLRISGVALHDQGQYECQAVNIIGS--QKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            GTL I GVA  D G Y CQA N +G+  + V  + T  P V+ V A +     V VG  
Sbjct: 542 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 597

Query: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
             L C + G P P + W + G+++  + +   S  G L I      DAG Y C A N +G
Sbjct: 598 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 655

Query: 602 SASVSMVLSV 611
            AS  + L+V
Sbjct: 656 DASAEIQLAV 665



 Score =  102 bits (254), Expect = 3e-21
 Identities = 69/259 (26%), Positives = 110/259 (42%), Gaps = 4/259 (1%)

Query: 357 ESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
           + + + CS     P R+   RG+   L  +     + +    I    + + G Y C+A +
Sbjct: 325 QPLLVSCSVHSALPFRLQLRRGEAR-LGEERHFQESGNSSWEILRASKAEEGTYECTAVS 383

Query: 417 NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
              +  A A I+V   P   V   +  V  G+T    C   G  P  + W +    L   
Sbjct: 384 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 443

Query: 477 RRHLV-LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
              +  L+  +L ISG+   D G+Y+C A N  G  +    L V  R  P  +   S   
Sbjct: 444 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSSQH 501

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
              G  V++ CS+ G P P I+W+++   + E  + H+  +G L I  V P DAG Y C 
Sbjct: 502 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 561

Query: 596 ARNTIGSASVSMVLSVNVP 614
           A N +G+   ++ L    P
Sbjct: 562 ATNEVGTDQETVTLYYTDP 580



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 69/215 (32%), Positives = 90/215 (41%), Gaps = 14/215 (6%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            PRI           G      C A G P P I W +  N L+ +     N+  +GTL+I 
Sbjct: 859  PRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR-GPHYNVSKEGTLLIA 917

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP------ARPTFVIQPQNTEVLVGESV 359
                 D G Y C A N  G   +QE+ L     P      +R   V  P       GE V
Sbjct: 918  QPSAQDAGAYVCTATNTVG-FSSQEMRLSVNTKPRIHMNGSRNANV--PLQVTAKAGEEV 974

Query: 360  TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID 419
            TL+C A G PPP ++WT+  R   P+  R  + PSG L +  V  GDSG Y C+A+N   
Sbjct: 975  TLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034

Query: 420  SVHATAFIIVQA----LPQFTVTPQDRVVIEGQTV 450
            S      + VQ      PQ    P     + G +V
Sbjct: 1035 SASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSV 1069



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 34/125 (27%), Positives = 54/125 (43%), Gaps = 1/125 (0%)

Query: 237  TPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL 296
            T   ++    R  + P      +G  V   C A+G+P P + W +++  +   T +R  L
Sbjct: 948  TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPIT-NRYGL 1006

Query: 297  LDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVG 356
            L  G+L +   Q  D G Y+C A N AG    + V      +  +P  +  P +   L G
Sbjct: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSG 1066

Query: 357  ESVTL 361
             SV L
Sbjct: 1067 LSVPL 1071


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  188 bits (477), Expect = 4e-47
 Identities = 121/388 (31%), Positives = 175/388 (45%), Gaps = 17/388 (4%)

Query: 229  QGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM 288
            QGR +  + P       P I   P +  +T+       C A G+PKP ++W ++  +L  
Sbjct: 2563 QGRDLRVLEP-------PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDF 2615

Query: 289  KTDS-RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVI 346
            +       LL    L++      D   ++C+  N  GE  +  +VT+        PT   
Sbjct: 2616 RLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH-----VPPTIAD 2670

Query: 347  QPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGD 406
               +  V +   V L C +TG P P +SW++             ++PSG L I   +   
Sbjct: 2671 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 2730

Query: 407  SGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW 466
            +G Y CSA N+    H   F+ VQA P     P     +  + V   CEA G P P I W
Sbjct: 2731 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2790

Query: 467  TKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526
             K G  ++      VL  G LRI+  +  D G Y C A N  GS      L VQ  V PV
Sbjct: 2791 QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ--VPPV 2848

Query: 527  FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVG 585
              +   D +   G++  LPC ++G PEP ITW+KDG  V+ + GKF I P G L + ++ 
Sbjct: 2849 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLE 2908

Query: 586  PADAGRYECVARNTIGSASVSMVLSVNV 613
              DAG Y C A N +G A   + L++ V
Sbjct: 2909 GQDAGTYTCTAENAVGRARRRVHLTILV 2936



 Score =  188 bits (477), Expect = 4e-47
 Identities = 120/370 (32%), Positives = 176/370 (47%), Gaps = 16/370 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I +   D   T G+  +  C+A G+P+P I W ++   +S   + +  +   G L+++
Sbjct: 2847 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVK 2905

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECS 364
            N +  D G Y C A+N  G  + +  +T+        P F   P +  + +G+ + L C+
Sbjct: 2906 NLEGQDAGTYTCTAENAVGRARRRVHLTILVL-----PVFTTLPGDRSLRLGDRLWLRCA 2960

Query: 365  ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQN--VVQGDSGEYACSATNNIDSVH 422
            A G P PRI WT  DR   PV   V+    GG  +Q   V + DSG Y C A N +    
Sbjct: 2961 ARGSPTPRIGWTVNDR---PVTEGVS-EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ 3016

Query: 423  ATAFIIVQALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
            A +F+ V+  P         +V   G ++   C  +G+P P I W K G  L        
Sbjct: 3017 AVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 3076

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            L +G+L I      D G+Y+C A N +G  K V  L +Q    PVF   P D TV  G +
Sbjct: 3077 LQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQS--APVFQVEPQDMTVRSGDD 3134

Query: 542  VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
            V L C + GEP P I W + G  +  S +    P+G L + +V   DAG Y+CVA N +G
Sbjct: 3135 VALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 3194

Query: 602  SASVSMVLSV 611
            SA+    L V
Sbjct: 3195 SATARAFLVV 3204



 Score =  176 bits (445), Expect = 2e-43
 Identities = 120/385 (31%), Positives = 166/385 (43%), Gaps = 10/385 (2%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I S P   +V+   T    C+A+G P P + W ++   L  ++  R  +L +G+L IQ
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP-RFEILPEGSLRIQ 2540

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
                 D G Y C+A N AG  + Q   LR    PA       P N  +       L C A
Sbjct: 2541 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 2596

Query: 366  TGHPPPRISWTR-GDRTPLPVDPRV-NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
            +G P P + W + G +    +      + PS  L +      DS ++ C  +N +   H 
Sbjct: 2597 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2656

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHLVL 482
               + V   P       D  V     V   C + G P P ++W+K G+QL      + V 
Sbjct: 2657 LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS 2716

Query: 483  SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANV 542
             SG L I        G+Y C A N  G       LTVQ   +PV   +PS         V
Sbjct: 2717 PSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ--ASPVVKPLPSVVRAVAEEEV 2774

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
             LPC + G P P ITW K+G+ V       + P G L I    P DAG Y C+A+N+ GS
Sbjct: 2775 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2834

Query: 603  ASVSMVLSVNVPDVSRNGDPFVATS 627
            A     L V VP V  NG P ++T+
Sbjct: 2835 AMGKTRLVVQVPPVIENGLPDLSTT 2859



 Score =  165 bits (417), Expect = 3e-40
 Identities = 113/369 (30%), Positives = 165/369 (44%), Gaps = 18/369 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P +   P      +   V   C A G P+P I W +    L++ T     +L  G L I 
Sbjct: 2757 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRIA 2814

Query: 306  NTQETDQGIYQCMAKNVAGEV--KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
            +    D G Y C+AKN AG    KT+ V          P       +     G    L C
Sbjct: 2815 HASPEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPC 2868

Query: 364  SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
             A G P P I+W +  +     + +  I PSG L ++N+   D+G Y C+A N +     
Sbjct: 2869 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2928

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS--VDRRHLV 481
               + +  LP FT  P DR +  G  +  +C A+G+P P I WT     ++  V  +   
Sbjct: 2929 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-- 2986

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVE-VGA 540
                TL+ + V+  D G Y C A N +G  + V+ + V  +  PV         VE VG 
Sbjct: 2987 -GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV--KEAPVLQGEAFSYLVEPVGG 3043

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI 600
            ++QL C  +G+P P I W KDG+ +  S   H    G LTI+     DAGRY+C+A N +
Sbjct: 3044 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 3103

Query: 601  GSASVSMVL 609
            G A   ++L
Sbjct: 3104 GVAKKVVIL 3112



 Score =  162 bits (411), Expect = 2e-39
 Identities = 114/403 (28%), Positives = 183/403 (45%), Gaps = 29/403 (7%)

Query: 244  ERPRI--TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
            E P I  + +P +  +T G  +   C A+G P+P I W ++   L+         L++ +
Sbjct: 2301 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNS 2352

Query: 302  LMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVIQPQNTEVLVGES-- 358
               +  +  D G+Y C+A++ AG + K+  V ++       P  ++ P+    +VG +  
Sbjct: 2353 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQ------APPNIVGPRGPRFVVGLAPG 2406

Query: 359  -VTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN 416
             + LECS    P P+I+W R D   L  D        G  L +Q +   DSG+Y+C+A N
Sbjct: 2407 QLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2465

Query: 417  NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV- 475
               S      + +  +P     P    V   QT    C+A G P P+++W K    L   
Sbjct: 2466 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2525

Query: 476  DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
              R  +L  G+LRI  V   D G Y C A N  GS +    L V     P  A  PS+ T
Sbjct: 2526 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE--PPAIAPSPSNLT 2583

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQV---TESGKFHISPEGFLTINDVGPADAGRY 592
            +       LPC + G P+P + W KDG ++    + G + + P   L +   GP D+ ++
Sbjct: 2584 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2643

Query: 593  ECVARNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIVEAIAT 634
            ECV  N +G A     ++V+V P ++ +   F  T +   + T
Sbjct: 2644 ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2686



 Score =  158 bits (399), Expect = 4e-38
 Identities = 120/391 (30%), Positives = 173/391 (44%), Gaps = 27/391 (6%)

Query: 246  PRITSE--PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL-LDDGTL 302
            PRI S    ++  V  G  V   C A+G P P++ WL++ + L       L   LD G+L
Sbjct: 2025 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 2084

Query: 303  MIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESV 359
            +++  + +D G Y C+A N AGE    +  L        PT       +  LV   GE V
Sbjct: 2085 VLKGLRASDAGAYTCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2140

Query: 360  TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI 418
            T+ C   G PP  +SW + D  PLP+  R  +  SG  L I  V   D+G + C A +  
Sbjct: 2141 TMVCPVRGSPPIHVSWLK-DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPA 2199

Query: 419  DSVHATAFIIVQALPQFTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
                    + VQ  P         D VV+ G  V+  CEA+G P P+++W K G  L   
Sbjct: 2200 GVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2259

Query: 477  RRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
                 L  G +L++  V   D G Y C AV+  G  +    LTV        +  P++ +
Sbjct: 2260 S----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELS 2315

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
            +  GA ++L C +QG P+P ITW+KDG  +T                 +   DAG Y C+
Sbjct: 2316 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNSRATRVLRVRDAGLYTCL 2369

Query: 596  ARNTIGSASVSMVLSVNVPD--VSRNGDPFV 624
            A +  G+   S  + V  P   V   G  FV
Sbjct: 2370 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFV 2400



 Score =  157 bits (396), Expect = 9e-38
 Identities = 124/379 (32%), Positives = 173/379 (45%), Gaps = 20/379 (5%)

Query: 253  QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETD 311
            ++  V + +TV   C A GNP P I WL+N   L      RL +L+DG  L +   +  D
Sbjct: 1662 EEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVAD 1719

Query: 312  QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
               Y C+A+N AG  + +  TLR    P R   +   Q T +L   SV+L C    HP P
Sbjct: 1720 AASYMCVAENQAGSAE-KLFTLR-VQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNP 1776

Query: 372  RISWTRGDRTPLPVDPRVNITP-SGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
             ++W + D   L +   V + P +  L +      DSG Y C A N          + V 
Sbjct: 1777 EVTWYK-DSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL 1835

Query: 431  ALPQFTVT---PQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG- 485
              P F      PQD V++  G      CE    P P + W K G  L + +R   L  G 
Sbjct: 1836 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1895

Query: 486  TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV-GANVQL 544
             L I    + D+G Y C+  N+ G       LTVQ  V P F +  ++T  +V G+ + L
Sbjct: 1896 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ--VPPTFENPKTETVSQVAGSPLVL 1953

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGKFH--ISPEGFLTINDVGPADAGRYECVARNTIGS 602
             C   G P P +TW KD + V ES   H  +S  G L ++ + PA AG Y CVA NT   
Sbjct: 1954 TCDVSGVPAPTVTWLKDRMPV-ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 2012

Query: 603  ASVSMVLSVNV-PDVSRNG 620
            A    V++V V P +  +G
Sbjct: 2013 ARKDFVVAVLVAPRIRSSG 2031



 Score =  156 bits (395), Expect = 1e-37
 Identities = 117/402 (29%), Positives = 180/402 (44%), Gaps = 19/402 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I   P +  V    +V   C A G P P++ W + +  +S      +++ D   L I+
Sbjct: 695  PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 753

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE--VLVGESVTLEC 363
              Q +D G Y+C+A NVAG  +     LRY      P  +  P +    VLV   V L C
Sbjct: 754  QAQLSDAGSYRCVASNVAGSTE-----LRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 808

Query: 364  SATGHPPPRISWTRGDRTPLPVD-PRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSV 421
            +ATG P P + W +      P   P + + P G  L + +    DSG Y+C A + +   
Sbjct: 809  NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHL 480
                 + V   P       +  V+  ++V  +C++   PPPV++W K G  L      HL
Sbjct: 869  RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 928

Query: 481  VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT-TVEVG 539
                  L++    + D G Y C+A+N  G  +   H  +   V PVF    S T TV  G
Sbjct: 929  SADKALLQVDRADVWDAGHYTCEALNQAGRSE--KHYNLNVWVAPVFPLRESHTLTVREG 986

Query: 540  ANVQLPCSSQGEPEPAITWNKDGVQV--TESGKFHISPEG-FLTINDVGPADAGRYECVA 596
                L C  +G P P I+W KDG  +    +G  H+S  G  L +     A  G Y C  
Sbjct: 987  HPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 1046

Query: 597  RNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIV-EAIATVD 636
             N +G++S  + L V+V P ++   +P    S+V + +AT++
Sbjct: 1047 SNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 1088



 Score =  149 bits (377), Expect = 1e-35
 Identities = 117/377 (31%), Positives = 168/377 (44%), Gaps = 20/377 (5%)

Query: 252  PQDAD-VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMIQNTQE 309
            PQDA  V  G+    +C  +  P+P + W ++   L +    R   L  G  L IQ  Q 
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLA--QRTQALRGGQRLEIQEAQV 1904

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPARPTFVIQPQNT-EVLVGESVTLECSATG 367
            +D+G+Y C   NVAGE V+T  +T++       PTF      T   + G  + L C  +G
Sbjct: 1905 SDKGLYSCKVSNVAGEAVRTFTLTVQ-----VPPTFENPKTETVSQVAGSPLVLTCDVSG 1959

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAF 426
             P P ++W + DR P+       +   GG L +  +    +G Y C A N          
Sbjct: 1960 VPAPTVTWLK-DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFV 2018

Query: 427  IIVQALPQFTVT--PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD---RRHLV 481
            + V   P+   +   ++  V+EGQ V   CEA G PPP +AW K GS L  D        
Sbjct: 2019 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 2078

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGA 540
            L  G+L + G+   D G Y C A N  G    +  + V    T    +  S T V   G 
Sbjct: 2079 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2138

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNT 599
             V + C  +G P   ++W KDG+ +  S +  +   G  L I+ V  ADAG + CVA + 
Sbjct: 2139 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASP 2198

Query: 600  IGSASVSMVLSVNVPDV 616
             G A  +  L V VP V
Sbjct: 2199 AGVADRNFTLQVQVPPV 2215



 Score =  144 bits (364), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 159/403 (39%), Gaps = 19/403 (4%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQET 310
            P    V         C A G P P + W R+   +  +    L L + G +L ++  Q  
Sbjct: 1074 PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG--LQLQNQGQSLHVERAQAA 1131

Query: 311  DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370
              G Y C+A+N+AG  + ++  L     P     +    N    +   +TL C A G PP
Sbjct: 1132 HTGRYSCVAENLAGRAE-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 1190

Query: 371  PRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
            P I W RG+    P +    +     L +    + DSG Y+C A+N          + V 
Sbjct: 1191 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL 1250

Query: 431  ALPQFTVTPQDRV--VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-L 487
              P       + V  V++GQT    C   G+P P + W K G  L+    H +   G  L
Sbjct: 1251 VPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLL 1310

Query: 488  RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA-----SIPSDTTVEVGANV 542
            ++    L   G Y C A N +G +    H  +   + P        S   + TV V   +
Sbjct: 1311 QVLQANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPI 1368

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNTIG 601
             L C +   P P ITW KDG     S    + P    L I +    DAG+Y CV  N +G
Sbjct: 1369 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1428

Query: 602  SASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
             A  +  + V +P      DP     + E    V   +NST T
Sbjct: 1429 EAVKNYHVEVLIPPSISKDDPLGEVGVKE----VKTKVNSTLT 1467



 Score =  141 bits (356), Expect = 4e-33
 Identities = 115/379 (30%), Positives = 162/379 (42%), Gaps = 31/379 (8%)

Query: 267  CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV 326
            C A G P P I W R    +S   D+ L L     L +  TQE D G+Y C+A N AGE 
Sbjct: 1183 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 1241

Query: 327  KTQEVTLRYFGSPARPTFVIQPQNTE----VLVGESVTLECSATGHPPPRISWTRGDRTP 382
            +      R F         I+ ++ E    VL G++  L C+ TGHP P+++W +  R P
Sbjct: 1242 R------RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR-P 1294

Query: 383  LPVDPRVNITPSGGLYIQNVVQGD---SGEYACSATNNIDSVHATAFIIVQALPQFTVTP 439
            L      +I+P G L    V+Q +   +G Y+C A N +        + V   P      
Sbjct: 1295 LARGDAHHISPDGVLL--QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGA 1352

Query: 440  QDRV-----VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT--LRISGV 492
            +D       V     +   CEA   P P I W K G+     R ++ L  GT  L+I   
Sbjct: 1353 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR-NIQLLPGTHGLQILNA 1411

Query: 493  ALHDQGQYECQAVNIIGSQKVVAHLTV--QPRVT---PVFASIPSDTTVEVGANVQLPCS 547
               D GQY C   N +G      H+ V   P ++   P+      +   +V + + L C 
Sbjct: 1412 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 1471

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVS 606
            S   P P I W KDG  VT S +  +  EG  L I     +D+GRY CVA N  G     
Sbjct: 1472 SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1531

Query: 607  MVLSVNVPDVSRNGDPFVA 625
              + + VP + +    F A
Sbjct: 1532 FNVLIQVPPMFQKVGDFSA 1550



 Score =  140 bits (354), Expect = 7e-33
 Identities = 109/393 (27%), Positives = 162/393 (41%), Gaps = 30/393 (7%)

Query: 250  SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQE 309
            S  ++  VT  N +   C A   P P I W+++        + +L L     L I N Q+
Sbjct: 1355 SADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQK 1413

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPAR--PTFVIQPQNTEVLVGESVTLECSAT 366
             D G Y C+  N  GE VK   V +    S ++  P   +  +  +  V  ++TLEC + 
Sbjct: 1414 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 1473

Query: 367  GHPPPRISWTRGDRTPLPVDPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATA 425
              PPP I W + D  P+    R+ +   G L  IQ     DSG Y C ATN         
Sbjct: 1474 AVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1532

Query: 426  FIIVQALPQFTVT--------------------PQDRVVIEGQTVDFQCEAKGNPPPVIA 465
             +++Q  P F                        + R ++E       C+    PPP + 
Sbjct: 1533 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1592

Query: 466  WTKGGSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV--QPR 522
            W +    LS      VL  G  L+I  V   + G+Y C+A N +G   +   L V   P 
Sbjct: 1593 WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPV 1652

Query: 523  VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTI 581
            +      +  + TV   + V L C + G P P I+W ++G+  + S +  +  +G  L +
Sbjct: 1653 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQV 1712

Query: 582  NDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            +    ADA  Y CVA N  GSA     L V VP
Sbjct: 1713 STAEVADAASYMCVAENQAGSAEKLFTLRVQVP 1745



 Score =  136 bits (342), Expect = 2e-31
 Identities = 122/458 (26%), Positives = 189/458 (41%), Gaps = 32/458 (6%)

Query: 212  ESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEG 271
            ++G        E    ++   V  + P  ++ + P      ++      +T+   C +  
Sbjct: 1415 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 1474

Query: 272  NPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNTQETDQGIYQCMAKNVAGE----- 325
             P P I W ++   ++    SRL +L +G L+ IQ TQ +D G Y C+A NVAGE     
Sbjct: 1475 VPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1532

Query: 326  -VKTQEVTLRYFGSPARPTFVIQPQNTE----------VLVGESVTLECSATGHPPPRIS 374
             V  Q   +          F I  +  E          ++      L C     PPP ++
Sbjct: 1533 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1592

Query: 375  WTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI--DSVHATAFIIVQA 431
            W R D+ PL     V++   G  L I  V   ++G Y+C A+N +  D +H    ++   
Sbjct: 1593 WYREDQ-PLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1651

Query: 432  --LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG-TLR 488
              L       ++  V    TV  QC A GNP P I+W + G   S   R  VL  G  L+
Sbjct: 1652 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 1711

Query: 489  ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP-SDTTVEVGANVQLPCS 547
            +S   + D   Y C A N  GS + +  L VQ  V P  A +     T  + ++V LPC 
Sbjct: 1712 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQ--VPPRIAGLDLEQVTAILNSSVSLPCD 1769

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISP-EGFLTINDVGPADAGRYECVARNTIGSASVS 606
                P P +TW KD   ++   +  + P    L +     +D+G Y C A N  G     
Sbjct: 1770 VHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL 1829

Query: 607  MVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
            + LSV VP   R        +++  +   D+A+ S  T
Sbjct: 1830 VQLSVLVPPAFRQAPRGPQDAVLVRVG--DKAVLSCET 1865



 Score =  132 bits (332), Expect = 2e-30
 Identities = 88/279 (31%), Positives = 126/279 (45%), Gaps = 15/279 (5%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMI 304
            P  T+ P D  +  G+ ++  C A G+P P I W  N+  ++     +    D G TL  
Sbjct: 2938 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQR 2993

Query: 305  QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESVTL 361
                  D G Y C A+N  G  +TQ V+  +     +   V+Q +    LV   G S+ L
Sbjct: 2994 AAVSREDSGTYVCWAENRVG--RTQAVSFVH----VKEAPVLQGEAFSYLVEPVGGSIQL 3047

Query: 362  ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            +C   G P P I W + D  PL      +   +G L I    + D+G Y C A N +   
Sbjct: 3048 DCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 3106

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
                 +++Q+ P F V PQD  V  G  V  +C+A G P P I W + G  L   RR   
Sbjct: 3107 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3166

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ 520
            L  G+L +  V   D G Y+C A N++GS    A L V+
Sbjct: 3167 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205



 Score =  130 bits (326), Expect = 1e-29
 Identities = 115/437 (26%), Positives = 178/437 (40%), Gaps = 40/437 (9%)

Query: 211 AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVT--SGNTVYFTCR 268
           A+SG+ +  A  E     +   +    P       P I  + + A+V+  +G ++   C 
Sbjct: 67  ADSGDYECQATNEVGSTSRRAKLVVYVP-------PSIREDGRKANVSGMAGQSLTLECD 119

Query: 269 AEGNPKPEIIWLRNNN-------------ELSMKTDSRLNLLDDGTLM----IQNTQETD 311
           A G P PEI+WL++               +L         LLD+G  +    IQ  +   
Sbjct: 120 ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGR 179

Query: 312 QGIY-----QCMAKNVAGEVKTQEVTLRYFGSPARPTFVI---QPQNTEVLVGESVTLEC 363
           +G       Q  A   AG    ++    +  SP  P  V+     Q    L G  V L+C
Sbjct: 180 RGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC 239

Query: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVH 422
             +G P P++ WT+  +  LP  P + +   G  L I     GD G Y C A +      
Sbjct: 240 WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 299

Query: 423 ATAFIIVQALPQFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHL 480
               + V A P    + +  +  V+E   V   CEA+G P P I W K G+ L    + +
Sbjct: 300 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 359

Query: 481 VLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSDTTVEV 538
               G  L++      D G Y C+A N +G+ +    L V  P         P       
Sbjct: 360 YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419

Query: 539 GANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVAR 597
           G  V L C ++G P P ++W+ +G+ V ES +  +  +G  L +   G A +G Y CVA 
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479

Query: 598 NTIGSASVSMVLSVNVP 614
           +  G A +   + V VP
Sbjct: 480 SPAGEAVLQYSVEVQVP 496



 Score =  130 bits (326), Expect = 1e-29
 Identities = 110/382 (28%), Positives = 162/382 (42%), Gaps = 42/382 (10%)

Query: 260 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
           G  +   C+A G+P P I WL+N          ++      TL I + +    G++ C A
Sbjct: 513 GQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV-ASQGTTLHIDHVELDHSGLFACQA 571

Query: 320 KNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRG 378
            N AG    + EV++    +P     V++    +   G        A   PP    W   
Sbjct: 572 TNEAGTAGAEVEVSVHGEWAPG----VLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 627

Query: 379 DRTPL-------------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
            + PL             P    V  +    L I+ V   D G Y C+ATN         
Sbjct: 628 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREV 687

Query: 426 FIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG--------GSQLSVDR 477
            + V   P     P ++ V+E  +V  +C A G PPP ++W KG        G  +SVD 
Sbjct: 688 ALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG 747

Query: 478 RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV--VAHLTVQPRVTPVFASIPSDTT 535
           R        LRI    L D G Y C A N+ GS ++     + V PR+T +  S+P    
Sbjct: 748 R-------VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRIT-LPPSLPG--P 797

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGK--FHISPEG-FLTINDVGPADAGRY 592
           V V   V+L C++ G P P + W KDG  V+ +G     + P G  LT+     +D+GRY
Sbjct: 798 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 857

Query: 593 ECVARNTIGSASVSMVLSVNVP 614
            CVA + +G     +VL V++P
Sbjct: 858 SCVAVSAVGEDRQDVVLQVHMP 879



 Score =  124 bits (312), Expect = 5e-28
 Identities = 103/398 (25%), Positives = 158/398 (39%), Gaps = 39/398 (9%)

Query: 267 CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV 326
           C   G PKP++ W +  +   +     + +L++G+L + +    D G Y+C A N  G  
Sbjct: 24  CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83

Query: 327 KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDR---TPL 383
             +   + Y     R     +  N   + G+S+TLEC A G P P I W +  +    PL
Sbjct: 84  SRRAKLVVYVPPSIREDG--RKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 141

Query: 384 ------------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQA 431
                        V     +     L+   +  G SG     A  +  +  A     +  
Sbjct: 142 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQT-KAPWXAGLAG 200

Query: 432 LPQFTV----------------TPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV 475
             QF                    Q+ + + G  V+ QC   G P P + WTK    +  
Sbjct: 201 FEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLP 260

Query: 476 DRRHLVLSSG--TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSD 533
              HL +      LRI+G  + D+G+Y+C A +  G Q     L V    T   ++   +
Sbjct: 261 GGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGE 320

Query: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRY 592
             V     VQL C ++G P P ITW KDG  +  S K   +  G  L +     +DAG Y
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 380

Query: 593 ECVARNTIGSASVSMVLSVNVPDV--SRNGDPFVATSI 628
            C A N +G+A  +  L V VP       G P+V  ++
Sbjct: 381 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 418



 Score =  121 bits (304), Expect = 4e-27
 Identities = 101/365 (27%), Positives = 162/365 (44%), Gaps = 19/365 (5%)

Query: 259 SGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETDQGIYQC 317
           +G  V   C   G P P++ W ++   + +     L + +DG  L I  +   D+G YQC
Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 289

Query: 318 MAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES--VTLECSATGHPPPRISW 375
           +A + AG+ + ++  LR     A PT     +  EV V E   V L C A G P P I+W
Sbjct: 290 VAFSPAGQ-QARDFQLRVH---APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 345

Query: 376 TRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
            + D   LP   +V  T  G  L +      D+G Y C A+N + +      + V   P 
Sbjct: 346 FK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 404

Query: 435 FTVT---PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-LRIS 490
                  P     + G+ V  +C A+G+P P ++W   G  ++      + + G+ LR+ 
Sbjct: 405 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLE 464

Query: 491 GVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP--VFASIPSDTTVEVGANVQLPCSS 548
                  G Y C A +  G  + V   +V+ +V P  + A      T  VG  ++LPC +
Sbjct: 465 SPGEASSGLYSCVASSPAG--EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 522

Query: 549 QGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSM 607
            G P P I W ++G    E     ++ +G  L I+ V    +G + C A N  G+A   +
Sbjct: 523 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 582

Query: 608 VLSVN 612
            +SV+
Sbjct: 583 EVSVH 587



 Score =  114 bits (284), Expect = 9e-25
 Identities = 60/175 (34%), Positives = 93/175 (53%), Gaps = 7/175 (4%)

Query: 260  GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
            G ++   C   G+P P+I W+++   L ++     + L +G+L I  T+  D G YQC+A
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 3099

Query: 320  KNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGD 379
            +N  G  K   + +      + P F ++PQ+  V  G+ V L C ATG P P I W +  
Sbjct: 3100 ENEMGVAKKVVILVLQ----SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3155

Query: 380  RTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
            + PL    R+   P G L+++NV  GD+G Y C A N + S  A AF++V+  PQ
Sbjct: 3156 Q-PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  188 bits (477), Expect = 4e-47
 Identities = 121/388 (31%), Positives = 175/388 (45%), Gaps = 17/388 (4%)

Query: 229  QGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM 288
            QGR +  + P       P I   P +  +T+       C A G+PKP ++W ++  +L  
Sbjct: 3754 QGRDLRVLEP-------PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDF 3806

Query: 289  KTDS-RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVI 346
            +       LL    L++      D   ++C+  N  GE  +  +VT+        PT   
Sbjct: 3807 RLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH-----VPPTIAD 3861

Query: 347  QPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGD 406
               +  V +   V L C +TG P P +SW++             ++PSG L I   +   
Sbjct: 3862 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 3921

Query: 407  SGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW 466
            +G Y CSA N+    H   F+ VQA P     P     +  + V   CEA G P P I W
Sbjct: 3922 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 3981

Query: 467  TKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526
             K G  ++      VL  G LRI+  +  D G Y C A N  GS      L VQ  V PV
Sbjct: 3982 QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ--VPPV 4039

Query: 527  FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVG 585
              +   D +   G++  LPC ++G PEP ITW+KDG  V+ + GKF I P G L + ++ 
Sbjct: 4040 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLE 4099

Query: 586  PADAGRYECVARNTIGSASVSMVLSVNV 613
              DAG Y C A N +G A   + L++ V
Sbjct: 4100 GQDAGTYTCTAENAVGRARRRVHLTILV 4127



 Score =  188 bits (477), Expect = 4e-47
 Identities = 120/370 (32%), Positives = 176/370 (47%), Gaps = 16/370 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I +   D   T G+  +  C+A G+P+P I W ++   +S   + +  +   G L+++
Sbjct: 4038 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVK 4096

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECS 364
            N +  D G Y C A+N  G  + +  +T+        P F   P +  + +G+ + L C+
Sbjct: 4097 NLEGQDAGTYTCTAENAVGRARRRVHLTILVL-----PVFTTLPGDRSLRLGDRLWLRCA 4151

Query: 365  ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQN--VVQGDSGEYACSATNNIDSVH 422
            A G P PRI WT  DR   PV   V+    GG  +Q   V + DSG Y C A N +    
Sbjct: 4152 ARGSPTPRIGWTVNDR---PVTEGVS-EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ 4207

Query: 423  ATAFIIVQALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
            A +F+ V+  P         +V   G ++   C  +G+P P I W K G  L        
Sbjct: 4208 AVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 4267

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            L +G+L I      D G+Y+C A N +G  K V  L +Q    PVF   P D TV  G +
Sbjct: 4268 LQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQS--APVFQVEPQDMTVRSGDD 4325

Query: 542  VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
            V L C + GEP P I W + G  +  S +    P+G L + +V   DAG Y+CVA N +G
Sbjct: 4326 VALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 4385

Query: 602  SASVSMVLSV 611
            SA+    L V
Sbjct: 4386 SATARAFLVV 4395



 Score =  184 bits (466), Expect = 7e-46
 Identities = 131/381 (34%), Positives = 168/381 (44%), Gaps = 21/381 (5%)

Query: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
           E P+++        + G  V  +C A G P P I W R +  L  + DSR+++   GTL+
Sbjct: 606 EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL--QEDSRIHVDAQGTLI 663

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV--GESVTL 361
           IQ     D G Y C A N  G    + VTL Y   P+     +   N  VLV  GE   L
Sbjct: 664 IQGVAPEDAGNYSCQATNEVG-TDQETVTLYYTDPPS-----VSAVNAVVLVAVGEEAVL 717

Query: 362 ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            C A+G PPPR+ W RG    L +      + SG L I    + D+G Y C A N +   
Sbjct: 718 VCEASGVPPPRVIWYRGG---LEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDA 774

Query: 422 HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG-----GSQLSVD 476
            A   + V   PQ T  P+D  V  G++    C A G PPP + W +G     G +L   
Sbjct: 775 SAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAG 834

Query: 477 R--RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
           R  R     SG L    VA  DQ  Y C+A N+ G  +  A L V     P  AS     
Sbjct: 835 RGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTV 894

Query: 535 TVEVGANVQLPC-SSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYE 593
            V  G  V LPC    G P P   W KDG  +    +  I  +G L ++      AGRY 
Sbjct: 895 RVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYS 954

Query: 594 CVARNTIGSASVSMVLSVNVP 614
           CVA NT GS    + L V VP
Sbjct: 955 CVATNTAGSQHRDVELVVQVP 975



 Score =  184 bits (466), Expect = 7e-46
 Identities = 126/368 (34%), Positives = 160/368 (43%), Gaps = 24/368 (6%)

Query: 257  VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
            V  G      C A G P P +IW R   E+ +  +        G L I   QE D G Y 
Sbjct: 709  VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGS----SSGKLRIPAAQERDAGTYT 764

Query: 317  CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWT 376
            C A N  G+    E+ L    +P        P++  V +G S  L C ATG PPP ++W 
Sbjct: 765  CRAVNELGDASA-EIQLAVGHAPQLTEL---PRDVTVELGRSALLACRATGRPPPTVTWR 820

Query: 377  RGDRTPLPV------DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV- 429
            RGD  PL +        R     SG L+ ++V   D   Y C A N    V A A +IV 
Sbjct: 821  RGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT 880

Query: 430  -QALPQFTVTPQDRVVIEGQTVDFQCEA-KGNPPPVIAWTKGGSQLSVDRRHLVLSSGTL 487
              A PQ   +     V+EGQ V   C    G P P   W K G  L    RH + + G+L
Sbjct: 881  GHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL 940

Query: 488  RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ--PRVTPVFASIPSDTTVEVGANVQLP 545
             +        G+Y C A N  GSQ     L VQ  PR+ P      +      G    LP
Sbjct: 941  HLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPT----ATHHITNEGVPASLP 996

Query: 546  CSSQGEPEPAITWNKDGVQVTESGK-FHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
            C + G P P ITW K+   +T  G  +++S EG L I      DAG Y C A NT+G +S
Sbjct: 997  CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 1056

Query: 605  VSMVLSVN 612
              M LSVN
Sbjct: 1057 QEMRLSVN 1064



 Score =  176 bits (445), Expect = 2e-43
 Identities = 120/385 (31%), Positives = 166/385 (43%), Gaps = 10/385 (2%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I S P   +V+   T    C+A+G P P + W ++   L  ++  R  +L +G+L IQ
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP-RFEILPEGSLRIQ 3731

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
                 D G Y C+A N AG  + Q   LR    PA       P N  +       L C A
Sbjct: 3732 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 3787

Query: 366  TGHPPPRISWTR-GDRTPLPVDPRV-NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
            +G P P + W + G +    +      + PS  L +      DS ++ C  +N +   H 
Sbjct: 3788 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 3847

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHLVL 482
               + V   P       D  V     V   C + G P P ++W+K G+QL      + V 
Sbjct: 3848 LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS 3907

Query: 483  SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANV 542
             SG L I        G+Y C A N  G       LTVQ   +PV   +PS         V
Sbjct: 3908 PSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ--ASPVVKPLPSVVRAVAEEEV 3965

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
             LPC + G P P ITW K+G+ V       + P G L I    P DAG Y C+A+N+ GS
Sbjct: 3966 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 4025

Query: 603  ASVSMVLSVNVPDVSRNGDPFVATS 627
            A     L V VP V  NG P ++T+
Sbjct: 4026 AMGKTRLVVQVPPVIENGLPDLSTT 4050



 Score =  172 bits (437), Expect = 2e-42
 Identities = 131/431 (30%), Positives = 181/431 (41%), Gaps = 74/431 (17%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE-----LSMKTDSRLNLLDDG 300
            P++T  P+D  V  G +    CRA G P P + W R + +     L     SR    D G
Sbjct: 786  PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845

Query: 301  TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
             L  ++    DQ  Y C A+NV G+V+  E  L   G  A P          VL G+ V+
Sbjct: 846  VLFFESVAPEDQAPYVCEARNVFGKVQA-EARLIVTGH-APPQIASSAPTVRVLEGQPVS 903

Query: 361  LECSA-TGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNID 419
            L C    G P P   W +  R PLP   R +I   G L++   +Q  +G Y+C ATN   
Sbjct: 904  LPCIVLAGRPLPERHWLKDGR-PLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962

Query: 420  SVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGS-------- 471
            S H    ++VQ  P+   T    +  EG      C A G P P I WTK  +        
Sbjct: 963  SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 1022

Query: 472  -------------------------------------QLSVDRRHL---------VLSSG 485
                                                 +LSV+R  L         +L SG
Sbjct: 1023 YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSG 1082

Query: 486  TLRISGVALHDQGQYECQAVNIIG--SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ 543
            +LR++ V + D G YEC A N  G  S + V  + V P+V P     P    V VG  + 
Sbjct: 1083 SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPG----PRVLKVLVGEALD 1138

Query: 544  LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSA 603
            L C ++G PEP ++W+KDGV +   G     P+G +    +  +DAGRY C A N+ G  
Sbjct: 1139 LNCVAEGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIRTSDAGRYRCEASNSAGVD 1193

Query: 604  SVSMVLSVNVP 614
            +  + L V  P
Sbjct: 1194 AWEVELRVLEP 1204



 Score =  170 bits (430), Expect = 1e-41
 Identities = 126/424 (29%), Positives = 178/424 (41%), Gaps = 28/424 (6%)

Query: 211 AESGNAQAAAICEYPR-RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA 269
           AE G  +  A+      R + + V T  P +L    P +T  P       G T   +CR 
Sbjct: 489 AEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL-VPAPNVTVSP-------GETAVLSCRV 540

Query: 270 EGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQ 329
            G     + W+R+   L   T  R+  L D +L I     TD G YQC+A N  G  +  
Sbjct: 541 LGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRAS 599

Query: 330 EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRV 389
              L        P   I   +     G  V + CSA+G+P P ISW+R +   L  D R+
Sbjct: 600 VWLL----VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQEDSRI 654

Query: 390 NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQT 449
           ++   G L IQ V   D+G Y+C ATN + +   T  +     P  +      +V  G+ 
Sbjct: 655 HVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEE 714

Query: 450 VDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG 509
               CEA G PPP + W +GG ++ +       SSG LRI      D G Y C+AVN +G
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 772

Query: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DG------ 562
                  L V     P    +P D TVE+G +  L C + G P P +TW + DG      
Sbjct: 773 DASAEIQLAVGH--APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLR 830

Query: 563 VQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG--SASVSMVLSVNVPDVSRNG 620
           +      +      G L    V P D   Y C ARN  G   A   ++++ + P    + 
Sbjct: 831 LGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS 890

Query: 621 DPFV 624
            P V
Sbjct: 891 APTV 894



 Score =  165 bits (417), Expect = 3e-40
 Identities = 113/369 (30%), Positives = 165/369 (44%), Gaps = 18/369 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P +   P      +   V   C A G P+P I W +    L++ T     +L  G L I 
Sbjct: 3948 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRIA 4005

Query: 306  NTQETDQGIYQCMAKNVAGEV--KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
            +    D G Y C+AKN AG    KT+ V          P       +     G    L C
Sbjct: 4006 HASPEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPC 4059

Query: 364  SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
             A G P P I+W +  +     + +  I PSG L ++N+   D+G Y C+A N +     
Sbjct: 4060 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 4119

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS--VDRRHLV 481
               + +  LP FT  P DR +  G  +  +C A+G+P P I WT     ++  V  +   
Sbjct: 4120 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-- 4177

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVE-VGA 540
                TL+ + V+  D G Y C A N +G  + V+ + V  +  PV         VE VG 
Sbjct: 4178 -GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV--KEAPVLQGEAFSYLVEPVGG 4234

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI 600
            ++QL C  +G+P P I W KDG+ +  S   H    G LTI+     DAGRY+C+A N +
Sbjct: 4235 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 4294

Query: 601  GSASVSMVL 609
            G A   ++L
Sbjct: 4295 GVAKKVVIL 4303



 Score =  162 bits (411), Expect = 2e-39
 Identities = 114/403 (28%), Positives = 183/403 (45%), Gaps = 29/403 (7%)

Query: 244  ERPRI--TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
            E P I  + +P +  +T G  +   C A+G P+P I W ++   L+         L++ +
Sbjct: 3492 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNS 3543

Query: 302  LMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVIQPQNTEVLVGES-- 358
               +  +  D G+Y C+A++ AG + K+  V ++       P  ++ P+    +VG +  
Sbjct: 3544 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQ------APPNIVGPRGPRFVVGLAPG 3597

Query: 359  -VTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN 416
             + LECS    P P+I+W R D   L  D        G  L +Q +   DSG+Y+C+A N
Sbjct: 3598 QLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 3656

Query: 417  NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV- 475
               S      + +  +P     P    V   QT    C+A G P P+++W K    L   
Sbjct: 3657 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 3716

Query: 476  DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
              R  +L  G+LRI  V   D G Y C A N  GS +    L V     P  A  PS+ T
Sbjct: 3717 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE--PPAIAPSPSNLT 3774

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQV---TESGKFHISPEGFLTINDVGPADAGRY 592
            +       LPC + G P+P + W KDG ++    + G + + P   L +   GP D+ ++
Sbjct: 3775 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 3834

Query: 593  ECVARNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIVEAIAT 634
            ECV  N +G A     ++V+V P ++ +   F  T +   + T
Sbjct: 3835 ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 3877



 Score =  158 bits (399), Expect = 4e-38
 Identities = 120/391 (30%), Positives = 173/391 (44%), Gaps = 27/391 (6%)

Query: 246  PRITSE--PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL-LDDGTL 302
            PRI S    ++  V  G  V   C A+G P P++ WL++ + L       L   LD G+L
Sbjct: 3216 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 3275

Query: 303  MIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESV 359
            +++  + +D G Y C+A N AGE    +  L        PT       +  LV   GE V
Sbjct: 3276 VLKGLRASDAGAYTCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 3331

Query: 360  TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI 418
            T+ C   G PP  +SW + D  PLP+  R  +  SG  L I  V   D+G + C A +  
Sbjct: 3332 TMVCPVRGSPPIHVSWLK-DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPA 3390

Query: 419  DSVHATAFIIVQALPQFTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
                    + VQ  P         D VV+ G  V+  CEA+G P P+++W K G  L   
Sbjct: 3391 GVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 3450

Query: 477  RRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
                 L  G +L++  V   D G Y C AV+  G  +    LTV        +  P++ +
Sbjct: 3451 S----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELS 3506

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
            +  GA ++L C +QG P+P ITW+KDG  +T                 +   DAG Y C+
Sbjct: 3507 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNSRATRVLRVRDAGLYTCL 3560

Query: 596  ARNTIGSASVSMVLSVNVPD--VSRNGDPFV 624
            A +  G+   S  + V  P   V   G  FV
Sbjct: 3561 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFV 3591



 Score =  157 bits (396), Expect = 9e-38
 Identities = 124/379 (32%), Positives = 173/379 (45%), Gaps = 20/379 (5%)

Query: 253  QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETD 311
            ++  V + +TV   C A GNP P I WL+N   L      RL +L+DG  L +   +  D
Sbjct: 2853 EEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVAD 2910

Query: 312  QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
               Y C+A+N AG  + +  TLR    P R   +   Q T +L   SV+L C    HP P
Sbjct: 2911 AASYMCVAENQAGSAE-KLFTLR-VQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNP 2967

Query: 372  RISWTRGDRTPLPVDPRVNITP-SGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
             ++W + D   L +   V + P +  L +      DSG Y C A N          + V 
Sbjct: 2968 EVTWYK-DSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL 3026

Query: 431  ALPQFTVT---PQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG- 485
              P F      PQD V++  G      CE    P P + W K G  L + +R   L  G 
Sbjct: 3027 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 3086

Query: 486  TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV-GANVQL 544
             L I    + D+G Y C+  N+ G       LTVQ  V P F +  ++T  +V G+ + L
Sbjct: 3087 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ--VPPTFENPKTETVSQVAGSPLVL 3144

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGKFH--ISPEGFLTINDVGPADAGRYECVARNTIGS 602
             C   G P P +TW KD + V ES   H  +S  G L ++ + PA AG Y CVA NT   
Sbjct: 3145 TCDVSGVPAPTVTWLKDRMPV-ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 3203

Query: 603  ASVSMVLSVNV-PDVSRNG 620
            A    V++V V P +  +G
Sbjct: 3204 ARKDFVVAVLVAPRIRSSG 3222



 Score =  156 bits (395), Expect = 1e-37
 Identities = 117/402 (29%), Positives = 180/402 (44%), Gaps = 19/402 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I   P +  V    +V   C A G P P++ W + +  +S      +++ D   L I+
Sbjct: 1886 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 1944

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE--VLVGESVTLEC 363
              Q +D G Y+C+A NVAG  +     LRY      P  +  P +    VLV   V L C
Sbjct: 1945 QAQLSDAGSYRCVASNVAGSTE-----LRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 1999

Query: 364  SATGHPPPRISWTRGDRTPLPVD-PRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSV 421
            +ATG P P + W +      P   P + + P G  L + +    DSG Y+C A + +   
Sbjct: 2000 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHL 480
                 + V   P       +  V+  ++V  +C++   PPPV++W K G  L      HL
Sbjct: 2060 RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 2119

Query: 481  VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT-TVEVG 539
                  L++    + D G Y C+A+N  G  +   H  +   V PVF    S T TV  G
Sbjct: 2120 SADKALLQVDRADVWDAGHYTCEALNQAGHSE--KHYNLNVWVAPVFPLRESHTLTVREG 2177

Query: 540  ANVQLPCSSQGEPEPAITWNKDGVQV--TESGKFHISPEG-FLTINDVGPADAGRYECVA 596
                L C  +G P P I+W KDG  +    +G  H+S  G  L +     A  G Y C  
Sbjct: 2178 HPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 2237

Query: 597  RNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIV-EAIATVD 636
             N +G++S  + L V+V P ++   +P    S+V + +AT++
Sbjct: 2238 SNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 2279



 Score =  151 bits (382), Expect = 4e-36
 Identities = 114/393 (29%), Positives = 172/393 (43%), Gaps = 36/393 (9%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P++   P+   V  G  +   C AEGNP+P++ W ++   L  +          G++   
Sbjct: 1120 PQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG-------PQGSVHFA 1172

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP---ARPTFVIQPQNTEVLVGESVTLE 362
              + +D G Y+C A N AG V   EV LR    P   A  T  +     E + GE+ +L 
Sbjct: 1173 AIRTSDAGRYRCEASNSAG-VDAWEVELRVLEPPHWGADETSGL----LERVAGENASLP 1227

Query: 363  CSATGHPPPRISWTRGDRT-PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            C A G P P+++W +G  + PL   P V +   G L++ +V   DSG+Y C ATN + S 
Sbjct: 1228 CPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 1287

Query: 422  HATAFIIVQALPQFTVTPQDRVV--IEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD--- 476
               A ++V   P      +   V  + GQ++  +C+A G P P I W K    + V    
Sbjct: 1288 SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 1347

Query: 477  ------------RRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV 523
                          H +L  G +L    +   D G Y C+A N  G+ +   HL V    
Sbjct: 1348 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 1407

Query: 524  TPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESG-KFHISPEG-FLTI 581
            + + A    +     GA+V+L C + G P P + W KD   V   G    +  +G  L I
Sbjct: 1408 SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRI 1467

Query: 582  NDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
                  D GRY+CVA +  G  +    L V+ P
Sbjct: 1468 TGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 1500



 Score =  149 bits (377), Expect = 1e-35
 Identities = 117/377 (31%), Positives = 168/377 (44%), Gaps = 20/377 (5%)

Query: 252  PQDAD-VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMIQNTQE 309
            PQDA  V  G+    +C  +  P+P + W ++   L +    R   L  G  L IQ  Q 
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLA--QRTQALRGGQRLEIQEAQV 3095

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPARPTFVIQPQNT-EVLVGESVTLECSATG 367
            +D+G+Y C   NVAGE V+T  +T++       PTF      T   + G  + L C  +G
Sbjct: 3096 SDKGLYSCKVSNVAGEAVRTFTLTVQ-----VPPTFENPKTETVSQVAGSPLVLTCDVSG 3150

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAF 426
             P P ++W + DR P+       +   GG L +  +    +G Y C A N          
Sbjct: 3151 VPAPTVTWLK-DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFV 3209

Query: 427  IIVQALPQFTVT--PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD---RRHLV 481
            + V   P+   +   ++  V+EGQ V   CEA G PPP +AW K GS L  D        
Sbjct: 3210 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 3269

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGA 540
            L  G+L + G+   D G Y C A N  G    +  + V    T    +  S T V   G 
Sbjct: 3270 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 3329

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNT 599
             V + C  +G P   ++W KDG+ +  S +  +   G  L I+ V  ADAG + CVA + 
Sbjct: 3330 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASP 3389

Query: 600  IGSASVSMVLSVNVPDV 616
             G A  +  L V VP V
Sbjct: 3390 AGVADRNFTLQVQVPPV 3406



 Score =  149 bits (376), Expect = 2e-35
 Identities = 108/392 (27%), Positives = 166/392 (42%), Gaps = 24/392 (6%)

Query: 259  SGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCM 318
            +G      C A G PKP++ W +  +   +     + +L++G+L + +    D G Y+C 
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279

Query: 319  AKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRG 378
            A N  G    +   + Y     R     +  N   + G+S+TLEC A G P P I W + 
Sbjct: 1280 ATNEVGSTSRRAKLVVYVPPSIREDG--RKANVSGMAGQSLTLECDANGFPVPEIVWLKD 1337

Query: 379  DR---TPL------------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
             +    PL             V     +     L+   + +GDSG Y+C A N   +   
Sbjct: 1338 AQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR 1397

Query: 424  TAFIIVQALPQF--TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
               ++V   P        Q+ + + G  V+ QC   G P P + WTK    +     HL 
Sbjct: 1398 DFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ 1457

Query: 482  LSSG--TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVG 539
            +      LRI+G  + D+G+Y+C A +  G Q     L V    T   ++   +  V   
Sbjct: 1458 VQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMED 1517

Query: 540  ANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARN 598
              VQL C ++G P P ITW KDG  +  S K   +  G  L +     +DAG Y C A N
Sbjct: 1518 HLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASN 1577

Query: 599  TIGSASVSMVLSVNVPDV--SRNGDPFVATSI 628
             +G+A  +  L V VP       G P+V  ++
Sbjct: 1578 AVGAAEKATRLDVYVPPTIEGAGGRPYVVKAV 1609



 Score =  145 bits (366), Expect = 3e-34
 Identities = 117/426 (27%), Positives = 178/426 (41%), Gaps = 31/426 (7%)

Query: 211  AESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVT--SGNTVYFTCR 268
            A+SG+ +  A  E     +   +    P       P I  + + A+V+  +G ++   C 
Sbjct: 1271 ADSGDYECQATNEVGSTSRRAKLVVYVP-------PSIREDGRKANVSGMAGQSLTLECD 1323

Query: 269  AEGNPKPEIIWLRNNN-------------ELSMKTDSRLNLLDDG-TLMIQNTQETDQGI 314
            A G P PEI+WL++               +L         LLD+G +L     QE D G+
Sbjct: 1324 ANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGL 1383

Query: 315  YQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRIS 374
            Y C A+N AG  +     L    +P         Q    L G  V L+C  +G P P++ 
Sbjct: 1384 YSCRAENQAGTAQRDFHLLVL--TPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVE 1441

Query: 375  WTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALP 433
            WT+  +  LP  P + +   G  L I     GD G Y C A +          + V A P
Sbjct: 1442 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 1501

Query: 434  QFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-LRIS 490
                + +  +  V+E   V   CEA+G P P I W K G+ L    + +    G  L++ 
Sbjct: 1502 TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLG 1561

Query: 491  GVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSDTTVEVGANVQLPCSSQ 549
                 D G Y C+A N +G+ +    L V  P         P       G  V L C ++
Sbjct: 1562 RAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVAR 1621

Query: 550  GEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSMV 608
            G P P ++W+ +G+ V ES +  +  +G  L +   G A +G Y CVA +  G A +   
Sbjct: 1622 GHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYS 1681

Query: 609  LSVNVP 614
            + V VP
Sbjct: 1682 VEVQVP 1687



 Score =  144 bits (364), Expect = 5e-34
 Identities = 109/403 (27%), Positives = 159/403 (39%), Gaps = 19/403 (4%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQET 310
            P    V         C A G P P + W R+   +  +    L L + G +L ++  Q  
Sbjct: 2265 PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG--LQLQNQGQSLHVERAQAA 2322

Query: 311  DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370
              G Y C+A+N+AG  + ++  L     P     +    N    +   +TL C A G PP
Sbjct: 2323 HTGRYSCVAENLAGRAE-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 2381

Query: 371  PRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
            P I W RG+    P +    +     L +    + DSG Y+C A+N          + V 
Sbjct: 2382 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL 2441

Query: 431  ALPQFTVTPQDRV--VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-L 487
              P       + V  V++GQT    C   G+P P + W K G  L+    H +   G  L
Sbjct: 2442 VPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLL 2501

Query: 488  RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA-----SIPSDTTVEVGANV 542
            ++    L   G Y C A N +G +    H  +   + P        S   + TV V   +
Sbjct: 2502 QVLQANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPI 2559

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNTIG 601
             L C +   P P ITW KDG     S    + P    L I +    DAG+Y CV  N +G
Sbjct: 2560 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 2619

Query: 602  SASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
             A  +  + V +P      DP     + E    V   +NST T
Sbjct: 2620 EAVKNYHVEVLIPPSISKDDPLGEVGVKE----VKTKVNSTLT 2658



 Score =  141 bits (356), Expect = 4e-33
 Identities = 115/379 (30%), Positives = 162/379 (42%), Gaps = 31/379 (8%)

Query: 267  CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV 326
            C A G P P I W R    +S   D+ L L     L +  TQE D G+Y C+A N AGE 
Sbjct: 2374 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 2432

Query: 327  KTQEVTLRYFGSPARPTFVIQPQNTE----VLVGESVTLECSATGHPPPRISWTRGDRTP 382
            +      R F         I+ ++ E    VL G++  L C+ TGHP P+++W +  R P
Sbjct: 2433 R------RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR-P 2485

Query: 383  LPVDPRVNITPSGGLYIQNVVQGD---SGEYACSATNNIDSVHATAFIIVQALPQFTVTP 439
            L      +I+P G L    V+Q +   +G Y+C A N +        + V   P      
Sbjct: 2486 LARGDAHHISPDGVLL--QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGA 2543

Query: 440  QDRV-----VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT--LRISGV 492
            +D       V     +   CEA   P P I W K G+     R ++ L  GT  L+I   
Sbjct: 2544 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR-NIQLLPGTHGLQILNA 2602

Query: 493  ALHDQGQYECQAVNIIGSQKVVAHLTV--QPRVT---PVFASIPSDTTVEVGANVQLPCS 547
               D GQY C   N +G      H+ V   P ++   P+      +   +V + + L C 
Sbjct: 2603 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECE 2662

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVS 606
            S   P P I W KDG  VT S +  +  EG  L I     +D+GRY CVA N  G     
Sbjct: 2663 SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 2722

Query: 607  MVLSVNVPDVSRNGDPFVA 625
              + + VP + +    F A
Sbjct: 2723 FNVLIQVPPMFQKVGDFSA 2741



 Score =  140 bits (354), Expect = 7e-33
 Identities = 109/393 (27%), Positives = 162/393 (41%), Gaps = 30/393 (7%)

Query: 250  SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQE 309
            S  ++  VT  N +   C A   P P I W+++        + +L L     L I N Q+
Sbjct: 2546 SADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQK 2604

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPAR--PTFVIQPQNTEVLVGESVTLECSAT 366
             D G Y C+  N  GE VK   V +    S ++  P   +  +  +  V  ++TLEC + 
Sbjct: 2605 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESW 2664

Query: 367  GHPPPRISWTRGDRTPLPVDPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATA 425
              PPP I W + D  P+    R+ +   G L  IQ     DSG Y C ATN         
Sbjct: 2665 AVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 2723

Query: 426  FIIVQALPQFTVT--------------------PQDRVVIEGQTVDFQCEAKGNPPPVIA 465
             +++Q  P F                        + R ++E       C+    PPP + 
Sbjct: 2724 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 2783

Query: 466  WTKGGSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV--QPR 522
            W +    LS      VL  G  L+I  V   + G+Y C+A N +G   +   L V   P 
Sbjct: 2784 WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPV 2843

Query: 523  VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTI 581
            +      +  + TV   + V L C + G P P I+W ++G+  + S +  +  +G  L +
Sbjct: 2844 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQV 2903

Query: 582  NDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            +    ADA  Y CVA N  GSA     L V VP
Sbjct: 2904 STAEVADAASYMCVAENQAGSAEKLFTLRVQVP 2936



 Score =  138 bits (347), Expect = 5e-32
 Identities = 96/310 (30%), Positives = 139/310 (44%), Gaps = 12/310 (3%)

Query: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
           I    + ++G Y+C A + AG   T     +   +   P  V  P N  V  GE+  L C
Sbjct: 483 ILRASKAEEGTYECTAVSRAG---TGRAKAQIVVTDPPPQLVPAP-NVTVSPGETAVLSC 538

Query: 364 SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
              G  P  ++W R  R       RV       L I  ++  D G Y C A+N      A
Sbjct: 539 RVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRA 598

Query: 424 TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLS 483
           + +++V+  PQ ++    +   +G  V   C A G P P I+W++    L  D R  V +
Sbjct: 599 SVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDA 658

Query: 484 SGTLRISGVALHDQGQYECQAVNIIGS--QKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            GTL I GVA  D G Y CQA N +G+  + V  + T  P V+ V A +     V VG  
Sbjct: 659 QGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV----LVAVGEE 714

Query: 542 VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
             L C + G P P + W + G+++  + +   S  G L I      DAG Y C A N +G
Sbjct: 715 AVLVCEASGVPPPRVIWYRGGLEMILAPEG--SSSGKLRIPAAQERDAGTYTCRAVNELG 772

Query: 602 SASVSMVLSV 611
            AS  + L+V
Sbjct: 773 DASAEIQLAV 782



 Score =  136 bits (342), Expect = 2e-31
 Identities = 122/458 (26%), Positives = 189/458 (41%), Gaps = 32/458 (6%)

Query: 212  ESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEG 271
            ++G        E    ++   V  + P  ++ + P      ++      +T+   C +  
Sbjct: 2606 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWA 2665

Query: 272  NPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNTQETDQGIYQCMAKNVAGE----- 325
             P P I W ++   ++    SRL +L +G L+ IQ TQ +D G Y C+A NVAGE     
Sbjct: 2666 VPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 2723

Query: 326  -VKTQEVTLRYFGSPARPTFVIQPQNTE----------VLVGESVTLECSATGHPPPRIS 374
             V  Q   +          F I  +  E          ++      L C     PPP ++
Sbjct: 2724 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 2783

Query: 375  WTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI--DSVHATAFIIVQA 431
            W R D+ PL     V++   G  L I  V   ++G Y+C A+N +  D +H    ++   
Sbjct: 2784 WYREDQ-PLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 2842

Query: 432  --LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG-TLR 488
              L       ++  V    TV  QC A GNP P I+W + G   S   R  VL  G  L+
Sbjct: 2843 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 2902

Query: 489  ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP-SDTTVEVGANVQLPCS 547
            +S   + D   Y C A N  GS + +  L VQ  V P  A +     T  + ++V LPC 
Sbjct: 2903 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQ--VPPRIAGLDLEQVTAILNSSVSLPCD 2960

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISP-EGFLTINDVGPADAGRYECVARNTIGSASVS 606
                P P +TW KD   ++   +  + P    L +     +D+G Y C A N  G     
Sbjct: 2961 VHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL 3020

Query: 607  MVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
            + LSV VP   R        +++  +   D+A+ S  T
Sbjct: 3021 VQLSVLVPPAFRQAPRGPQDAVLVRVG--DKAVLSCET 3056



 Score =  132 bits (332), Expect = 2e-30
 Identities = 88/279 (31%), Positives = 126/279 (45%), Gaps = 15/279 (5%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMI 304
            P  T+ P D  +  G+ ++  C A G+P P I W  N+  ++     +    D G TL  
Sbjct: 4129 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQR 4184

Query: 305  QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESVTL 361
                  D G Y C A+N  G  +TQ V+  +     +   V+Q +    LV   G S+ L
Sbjct: 4185 AAVSREDSGTYVCWAENRVG--RTQAVSFVH----VKEAPVLQGEAFSYLVEPVGGSIQL 4238

Query: 362  ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            +C   G P P I W + D  PL      +   +G L I    + D+G Y C A N +   
Sbjct: 4239 DCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVA 4297

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
                 +++Q+ P F V PQD  V  G  V  +C+A G P P I W + G  L   RR   
Sbjct: 4298 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 4357

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ 520
            L  G+L +  V   D G Y+C A N++GS    A L V+
Sbjct: 4358 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396



 Score =  130 bits (326), Expect = 1e-29
 Identities = 110/382 (28%), Positives = 162/382 (42%), Gaps = 42/382 (10%)

Query: 260  GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
            G  +   C+A G+P P I WL+N          ++      TL I + +    G++ C A
Sbjct: 1704 GQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV-ASQGTTLHIDHVELDHSGLFACQA 1762

Query: 320  KNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRG 378
             N AG    + EV++    +P     V++    +   G        A   PP    W   
Sbjct: 1763 TNEAGTAGAEVEVSVHGEWAPG----VLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 1818

Query: 379  DRTPL-------------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
             + PL             P    V  +    L I+ V   D G Y C+ATN         
Sbjct: 1819 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREV 1878

Query: 426  FIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG--------GSQLSVDR 477
             + V   P     P ++ V+E  +V  +C A G PPP ++W KG        G  +SVD 
Sbjct: 1879 ALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG 1938

Query: 478  RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV--VAHLTVQPRVTPVFASIPSDTT 535
            R        LRI    L D G Y C A N+ GS ++     + V PR+T +  S+P    
Sbjct: 1939 R-------VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRIT-LPPSLPG--P 1988

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGK--FHISPEG-FLTINDVGPADAGRY 592
            V V   V+L C++ G P P + W KDG  V+ +G     + P G  LT+     +D+GRY
Sbjct: 1989 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 2048

Query: 593  ECVARNTIGSASVSMVLSVNVP 614
             CVA + +G     +VL V++P
Sbjct: 2049 SCVAVSAVGEDRQDVVLQVHMP 2070



 Score =  122 bits (305), Expect = 3e-27
 Identities = 106/377 (28%), Positives = 154/377 (40%), Gaps = 37/377 (9%)

Query: 258  TSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQC 317
            T+ NTV F+ +       E+    N   LS        LL  G+L +   Q  D G Y+C
Sbjct: 1047 TATNTVGFSSQ-------EMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYEC 1099

Query: 318  MAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTR 377
             A N AG    + V     G    P     P+  +VLVGE++ L C A G+P P++SW++
Sbjct: 1100 TASNPAGSASHRYV----LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK 1155

Query: 378  GDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTV 437
             D   L         P G ++   +   D+G Y C A+N+         + V   P +  
Sbjct: 1156 -DGVVLQ-----GRGPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGA 1209

Query: 438  TPQDRVV--IEGQTVDFQCEAKGNPPPVIAWTKGGSQ--LSVDRRHLVLSSGTLRISGVA 493
                 ++  + G+     C A+G P P + W KG S   L       VL  G+L ++ V+
Sbjct: 1210 DETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS 1269

Query: 494  LHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPE 553
              D G YECQA N +GS    A L V    +       ++ +   G ++ L C + G P 
Sbjct: 1270 PADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 1329

Query: 554  PAITWNKDGVQV---------------TESGKFHISPEG-FLTINDVGPADAGRYECVAR 597
            P I W KD   V                + G   +  EG  L    +   D+G Y C A 
Sbjct: 1330 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAE 1389

Query: 598  NTIGSASVSMVLSVNVP 614
            N  G+A     L V  P
Sbjct: 1390 NQAGTAQRDFHLLVLTP 1406



 Score =  121 bits (304), Expect = 4e-27
 Identities = 101/365 (27%), Positives = 162/365 (44%), Gaps = 19/365 (5%)

Query: 259  SGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETDQGIYQC 317
            +G  V   C   G P P++ W ++   + +     L + +DG  L I  +   D+G YQC
Sbjct: 1422 AGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 1480

Query: 318  MAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES--VTLECSATGHPPPRISW 375
            +A + AG+ + ++  LR     A PT     +  EV V E   V L C A G P P I+W
Sbjct: 1481 VAFSPAGQ-QARDFQLRVH---APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 1536

Query: 376  TRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
             + D   LP   +V  T  G  L +      D+G Y C A+N + +      + V   P 
Sbjct: 1537 FK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 1595

Query: 435  FTVT---PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-LRIS 490
                   P     + G+ V  +C A+G+P P ++W   G  ++      + + G+ LR+ 
Sbjct: 1596 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLE 1655

Query: 491  GVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP--VFASIPSDTTVEVGANVQLPCSS 548
                   G Y C A +  G  + V   +V+ +V P  + A      T  VG  ++LPC +
Sbjct: 1656 SPGEASSGLYSCVASSPAG--EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713

Query: 549  QGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSM 607
             G P P I W ++G    E     ++ +G  L I+ V    +G + C A N  G+A   +
Sbjct: 1714 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 1773

Query: 608  VLSVN 612
             +SV+
Sbjct: 1774 EVSVH 1778



 Score =  114 bits (284), Expect = 9e-25
 Identities = 60/175 (34%), Positives = 93/175 (53%), Gaps = 7/175 (4%)

Query: 260  GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
            G ++   C   G+P P+I W+++   L ++     + L +G+L I  T+  D G YQC+A
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 4290

Query: 320  KNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGD 379
            +N  G  K   + +      + P F ++PQ+  V  G+ V L C ATG P P I W +  
Sbjct: 4291 ENEMGVAKKVVILVLQ----SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 4346

Query: 380  RTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
            + PL    R+   P G L+++NV  GD+G Y C A N + S  A AF++V+  PQ
Sbjct: 4347 Q-PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400



 Score =  102 bits (254), Expect = 3e-21
 Identities = 69/259 (26%), Positives = 110/259 (42%), Gaps = 4/259 (1%)

Query: 357 ESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
           + + + CS     P R+   RG+   L  +     + +    I    + + G Y C+A +
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEAR-LGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500

Query: 417 NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
              +  A A I+V   P   V   +  V  G+T    C   G  P  + W +    L   
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPAS 560

Query: 477 RRHLV-LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
              +  L+  +L ISG+   D G+Y+C A N  G  +    L V  R  P  +   S   
Sbjct: 561 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV--REAPQVSIHTSSQH 618

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
              G  V++ CS+ G P P I+W+++   + E  + H+  +G L I  V P DAG Y C 
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQ 678

Query: 596 ARNTIGSASVSMVLSVNVP 614
           A N +G+   ++ L    P
Sbjct: 679 ATNEVGTDQETVTLYYTDP 697


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  188 bits (477), Expect = 4e-47
 Identities = 121/388 (31%), Positives = 175/388 (45%), Gaps = 17/388 (4%)

Query: 229  QGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM 288
            QGR +  + P       P I   P +  +T+       C A G+PKP ++W ++  +L  
Sbjct: 2472 QGRDLRVLEP-------PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDF 2524

Query: 289  KTDS-RLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVI 346
            +       LL    L++      D   ++C+  N  GE  +  +VT+        PT   
Sbjct: 2525 RLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVH-----VPPTIAD 2579

Query: 347  QPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGD 406
               +  V +   V L C +TG P P +SW++             ++PSG L I   +   
Sbjct: 2580 DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIH 2639

Query: 407  SGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAW 466
            +G Y CSA N+    H   F+ VQA P     P     +  + V   CEA G P P I W
Sbjct: 2640 AGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITW 2699

Query: 467  TKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526
             K G  ++      VL  G LRI+  +  D G Y C A N  GS      L VQ  V PV
Sbjct: 2700 QKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ--VPPV 2757

Query: 527  FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES-GKFHISPEGFLTINDVG 585
              +   D +   G++  LPC ++G PEP ITW+KDG  V+ + GKF I P G L + ++ 
Sbjct: 2758 IENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLE 2817

Query: 586  PADAGRYECVARNTIGSASVSMVLSVNV 613
              DAG Y C A N +G A   + L++ V
Sbjct: 2818 GQDAGTYTCTAENAVGRARRRVHLTILV 2845



 Score =  188 bits (477), Expect = 4e-47
 Identities = 120/370 (32%), Positives = 176/370 (47%), Gaps = 16/370 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I +   D   T G+  +  C+A G+P+P I W ++   +S   + +  +   G L+++
Sbjct: 2756 PVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS-GAEGKFTIQPSGELLVK 2814

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECS 364
            N +  D G Y C A+N  G  + +  +T+        P F   P +  + +G+ + L C+
Sbjct: 2815 NLEGQDAGTYTCTAENAVGRARRRVHLTILVL-----PVFTTLPGDRSLRLGDRLWLRCA 2869

Query: 365  ATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQN--VVQGDSGEYACSATNNIDSVH 422
            A G P PRI WT  DR   PV   V+    GG  +Q   V + DSG Y C A N +    
Sbjct: 2870 ARGSPTPRIGWTVNDR---PVTEGVS-EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQ 2925

Query: 423  ATAFIIVQALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
            A +F+ V+  P         +V   G ++   C  +G+P P I W K G  L        
Sbjct: 2926 AVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 2985

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGAN 541
            L +G+L I      D G+Y+C A N +G  K V  L +Q    PVF   P D TV  G +
Sbjct: 2986 LQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQS--APVFQVEPQDMTVRSGDD 3043

Query: 542  VQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIG 601
            V L C + GEP P I W + G  +  S +    P+G L + +V   DAG Y+CVA N +G
Sbjct: 3044 VALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLG 3103

Query: 602  SASVSMVLSV 611
            SA+    L V
Sbjct: 3104 SATARAFLVV 3113



 Score =  176 bits (445), Expect = 2e-43
 Identities = 120/385 (31%), Positives = 166/385 (43%), Gaps = 10/385 (2%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P I S P   +V+   T    C+A+G P P + W ++   L  ++  R  +L +G+L IQ
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSP-RFEILPEGSLRIQ 2449

Query: 306  NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSA 365
                 D G Y C+A N AG  + Q   LR    PA       P N  +       L C A
Sbjct: 2450 PVLAQDAGHYLCLASNSAGSDR-QGRDLRVLEPPA---IAPSPSNLTLTAHTPALLPCEA 2505

Query: 366  TGHPPPRISWTR-GDRTPLPVDPRV-NITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
            +G P P + W + G +    +      + PS  L +      DS ++ C  +N +   H 
Sbjct: 2506 SGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHR 2565

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHLVL 482
               + V   P       D  V     V   C + G P P ++W+K G+QL      + V 
Sbjct: 2566 LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVS 2625

Query: 483  SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANV 542
             SG L I        G+Y C A N  G       LTVQ   +PV   +PS         V
Sbjct: 2626 PSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ--ASPVVKPLPSVVRAVAEEEV 2683

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGS 602
             LPC + G P P ITW K+G+ V       + P G L I    P DAG Y C+A+N+ GS
Sbjct: 2684 LLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGS 2743

Query: 603  ASVSMVLSVNVPDVSRNGDPFVATS 627
            A     L V VP V  NG P ++T+
Sbjct: 2744 AMGKTRLVVQVPPVIENGLPDLSTT 2768



 Score =  164 bits (416), Expect = 4e-40
 Identities = 113/369 (30%), Positives = 164/369 (44%), Gaps = 18/369 (4%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
            P +   P      +   V   C A G P+P I W +    L++ T     +L  G L I 
Sbjct: 2666 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG--LNVATGVSTQVLPGGQLRIA 2723

Query: 306  NTQETDQGIYQCMAKNVAGEV--KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
            +    D G Y C+AKN AG    KT+ V          P       +     G    L C
Sbjct: 2724 HASPEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPC 2777

Query: 364  SATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHA 423
             A G P P I+W +  +     + +  I PSG L ++N+   D+G Y C+A N +     
Sbjct: 2778 KARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARR 2837

Query: 424  TAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS--VDRRHLV 481
               + +  LP FT  P DR +  G  +  +C A+G+P P I WT     ++  V  +   
Sbjct: 2838 RVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQD-- 2895

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVE-VGA 540
                TL+ + V+  D G Y C A N +G  + V+ + V  +  PV         VE VG 
Sbjct: 2896 -GGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHV--KEAPVLQGEAFSYLVEPVGG 2952

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTI 600
            ++QL C  +G+P P I W KDG+ +  S   H    G LTI      DAGRY+C+A N +
Sbjct: 2953 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEM 3012

Query: 601  GSASVSMVL 609
            G A   ++L
Sbjct: 3013 GVAKKVVIL 3021



 Score =  162 bits (411), Expect = 2e-39
 Identities = 114/403 (28%), Positives = 183/403 (45%), Gaps = 29/403 (7%)

Query: 244  ERPRI--TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT 301
            E P I  + +P +  +T G  +   C A+G P+P I W ++   L+         L++ +
Sbjct: 2210 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTR--------LENNS 2261

Query: 302  LMIQNTQETDQGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVIQPQNTEVLVGES-- 358
               +  +  D G+Y C+A++ AG + K+  V ++       P  ++ P+    +VG +  
Sbjct: 2262 RATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQ------APPNIVGPRGPRFVVGLAPG 2315

Query: 359  -VTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN 416
             + LECS    P P+I+W R D   L  D        G  L +Q +   DSG+Y+C+A N
Sbjct: 2316 QLVLECSVEAEPAPKITWHR-DGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2374

Query: 417  NIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV- 475
               S      + +  +P     P    V   QT    C+A G P P+++W K    L   
Sbjct: 2375 AAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPR 2434

Query: 476  DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
              R  +L  G+LRI  V   D G Y C A N  GS +    L V     P  A  PS+ T
Sbjct: 2435 SPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLE--PPAIAPSPSNLT 2492

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQV---TESGKFHISPEGFLTINDVGPADAGRY 592
            +       LPC + G P+P + W KDG ++    + G + + P   L +   GP D+ ++
Sbjct: 2493 LTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQF 2552

Query: 593  ECVARNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIVEAIAT 634
            ECV  N +G A     ++V+V P ++ +   F  T +   + T
Sbjct: 2553 ECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLT 2595



 Score =  158 bits (399), Expect = 4e-38
 Identities = 120/391 (30%), Positives = 173/391 (44%), Gaps = 27/391 (6%)

Query: 246  PRITSE--PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNL-LDDGTL 302
            PRI S    ++  V  G  V   C A+G P P++ WL++ + L       L   LD G+L
Sbjct: 1934 PRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993

Query: 303  MIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESV 359
            +++  + +D G Y C+A N AGE    +  L        PT       +  LV   GE V
Sbjct: 1994 VLKGLRASDAGAYTCVAHNPAGE----DARLHTVNVLVPPTIKQGADGSGTLVSRPGELV 2049

Query: 360  TLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI 418
            T+ C   G PP  +SW + D  PLP+  R  +  SG  L I  V   D+G + C A +  
Sbjct: 2050 TMVCPVRGSPPIHVSWLK-DGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPA 2108

Query: 419  DSVHATAFIIVQALPQFTVTP--QDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD 476
                    + VQ  P         D VV+ G  V+  CEA+G P P+++W K G  L   
Sbjct: 2109 GVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQ 2168

Query: 477  RRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTT 535
                 L  G +L++  V   D G Y C AV+  G  +    LTV        +  P++ +
Sbjct: 2169 S----LEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELS 2224

Query: 536  VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECV 595
            +  GA ++L C +QG P+P ITW+KDG  +T                 +   DAG Y C+
Sbjct: 2225 LTPGAPMELLCDAQGTPQPNITWHKDGQALTR------LENNSRATRVLRVRDAGLYTCL 2278

Query: 596  ARNTIGSASVSMVLSVNVPD--VSRNGDPFV 624
            A +  G+   S  + V  P   V   G  FV
Sbjct: 2279 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFV 2309



 Score =  157 bits (396), Expect = 9e-38
 Identities = 117/402 (29%), Positives = 181/402 (45%), Gaps = 19/402 (4%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
           P I   P +  V    +V   C A G P P++ W + +  +S      +++ D   L I+
Sbjct: 604 PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSV-DGRVLRIE 662

Query: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTE--VLVGESVTLEC 363
             Q +D G Y+C+A NVAG  +     LRY      P  +  P +    VLV   V L C
Sbjct: 663 QAQLSDAGSYRCVASNVAGSTE-----LRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTC 717

Query: 364 SATGHPPPRISWTRGDRTPLPVD-PRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSV 421
           +ATG P P + W +      P   P + + P G  L + +    DSG Y+C A + +   
Sbjct: 718 NATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777

Query: 422 HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSV-DRRHL 480
                + V   P       +  V+  ++V  +C++   PPPV++W K G  L      HL
Sbjct: 778 RQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHL 837

Query: 481 VLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT-TVEVG 539
                 L++    + D G Y C+A+N  G  +   H  +   V PVF    S T TV  G
Sbjct: 838 SADKALLQVDRADVWDAGHYTCEALNQAGHSE--KHYNLNVWVAPVFPLRESHTLTVREG 895

Query: 540 ANVQLPCSSQGEPEPAITWNKDGVQV--TESGKFHISPEG-FLTINDVGPADAGRYECVA 596
              +L C  +G P P I+W KDG  +    +G  H+S  G  L +     A  G Y C  
Sbjct: 896 HPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCEC 955

Query: 597 RNTIGSASVSMVLSVNV-PDVSRNGDPFVATSIV-EAIATVD 636
            N +G++S  + L V+V P ++   +P    S+V + +AT++
Sbjct: 956 SNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLE 997



 Score =  157 bits (396), Expect = 9e-38
 Identities = 124/379 (32%), Positives = 173/379 (45%), Gaps = 20/379 (5%)

Query: 253  QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETD 311
            ++  V + +TV   C A GNP P I WL+N   L      RL +L+DG  L +   +  D
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVAD 1628

Query: 312  QGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPP 371
               Y C+A+N AG  + +  TLR    P R   +   Q T +L   SV+L C    HP P
Sbjct: 1629 AASYMCVAENQAGSAE-KLFTLR-VQVPPRIAGLDLEQVTAIL-NSSVSLPCDVHAHPNP 1685

Query: 372  RISWTRGDRTPLPVDPRVNITP-SGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
             ++W + D   L +   V + P +  L +      DSG Y C A N          + V 
Sbjct: 1686 EVTWYK-DSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVL 1744

Query: 431  ALPQFTVT---PQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG- 485
              P F      PQD V++  G      CE    P P + W K G  L + +R   L  G 
Sbjct: 1745 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1804

Query: 486  TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEV-GANVQL 544
             L I    + D+G Y C+  N+ G       LTVQ  V P F +  ++T  +V G+ + L
Sbjct: 1805 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ--VPPTFENPKTETVSQVAGSPLVL 1862

Query: 545  PCSSQGEPEPAITWNKDGVQVTESGKFH--ISPEGFLTINDVGPADAGRYECVARNTIGS 602
             C   G P P +TW KD + V ES   H  +S  G L ++ + PA AG Y CVA NT   
Sbjct: 1863 TCDVSGVPAPTVTWLKDRMPV-ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAE 1921

Query: 603  ASVSMVLSVNV-PDVSRNG 620
            A    V++V V P +  +G
Sbjct: 1922 ARKDFVVAVLVAPRIRSSG 1940



 Score =  149 bits (377), Expect = 1e-35
 Identities = 117/377 (31%), Positives = 168/377 (44%), Gaps = 20/377 (5%)

Query: 252  PQDAD-VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMIQNTQE 309
            PQDA  V  G+    +C  +  P+P + W ++   L +    R   L  G  L IQ  Q 
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLA--QRTQALRGGQRLEIQEAQV 1813

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPARPTFVIQPQNT-EVLVGESVTLECSATG 367
            +D+G+Y C   NVAGE V+T  +T++       PTF      T   + G  + L C  +G
Sbjct: 1814 SDKGLYSCKVSNVAGEAVRTFTLTVQ-----VPPTFENPKTETVSQVAGSPLVLTCDVSG 1868

Query: 368  HPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAF 426
             P P ++W + DR P+       +   GG L +  +    +G Y C A N          
Sbjct: 1869 VPAPTVTWLK-DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFV 1927

Query: 427  IIVQALPQFTVT--PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVD---RRHLV 481
            + V   P+   +   ++  V+EGQ V   CEA G PPP +AW K GS L  D        
Sbjct: 1928 VAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFY 1987

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTV-EVGA 540
            L  G+L + G+   D G Y C A N  G    +  + V    T    +  S T V   G 
Sbjct: 1988 LDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGE 2047

Query: 541  NVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNT 599
             V + C  +G P   ++W KDG+ +  S +  +   G  L I+ V  ADAG + CVA + 
Sbjct: 2048 LVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASP 2107

Query: 600  IGSASVSMVLSVNVPDV 616
             G A  +  L V VP V
Sbjct: 2108 AGVADRNFTLQVQVPPV 2124



 Score =  145 bits (367), Expect = 2e-34
 Identities = 109/403 (27%), Positives = 159/403 (39%), Gaps = 19/403 (4%)

Query: 252  PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQET 310
            P    V         C A G P P + W R+   +  +    L L + G +L ++  Q  
Sbjct: 983  PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG--LQLQNQGQSLHVERAQAA 1040

Query: 311  DQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370
              G Y C+A+N+AG  + ++  L     P     +    N    +   +TL C A G PP
Sbjct: 1041 HTGRYSCVAENLAGRAE-RKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 1099

Query: 371  PRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQ 430
            P I W RG+    P +    +     L +    + DSG Y+C A+N          + V 
Sbjct: 1100 PAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL 1159

Query: 431  ALPQFTVTPQDRV--VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-L 487
              P       + V  V++GQT    C   G+P P + W K G  L+    H +   G  L
Sbjct: 1160 VPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLL 1219

Query: 488  RISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA-----SIPSDTTVEVGANV 542
            ++    L   G Y C A N +G +    H  +   + P        S   + TV V   +
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEK--TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPI 1277

Query: 543  QLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGF-LTINDVGPADAGRYECVARNTIG 601
             L C +   P P ITW KDG     S    + P    L I +    DAG+Y CV  N +G
Sbjct: 1278 SLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337

Query: 602  SASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
             A  +  + V +P      DP     + E    V   +NST T
Sbjct: 1338 EAVKNYHVEVLIPPSISKDDPLAEVGVKE----VKTKVNSTLT 1376



 Score =  145 bits (365), Expect = 4e-34
 Identities = 111/391 (28%), Positives = 167/391 (42%), Gaps = 24/391 (6%)

Query: 246 PRITSEPQDADVT--SGNTVYFTCRAEGNPKPEIIWLRNNN-------------ELSMKT 290
           P I  + + A+V+  +G ++   C A G P PEI+WL++               +L    
Sbjct: 17  PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ 76

Query: 291 DSRLNLLDDG-TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQ 349
                LLD+G +L     QE D G+Y C A+N AG  +     L    +P         Q
Sbjct: 77  VGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL--TPPSVLGAGAAQ 134

Query: 350 NTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSG 408
               L G  V L+C  +G P P++ WT+  +  LP  P + +   G  L I     GD G
Sbjct: 135 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194

Query: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQ--DRVVIEGQTVDFQCEAKGNPPPVIAW 466
            Y C A +          + V A P    + +  +  V+E   V   CEA+G P P I W
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254

Query: 467 TKGGSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVT 524
            K G+ L    + +    G  L++      D G Y C+A N +G+ +    L V  P   
Sbjct: 255 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTI 314

Query: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTIND 583
                 P       G  V L C ++G P P ++W+ +G+ V ES +  +  +G  L +  
Sbjct: 315 EGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLES 374

Query: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            G A +G Y CVA +  G A +   + V VP
Sbjct: 375 PGEASSGLYSCVASSPAGEAVLQYSVEVQVP 405



 Score =  142 bits (357), Expect = 3e-33
 Identities = 115/379 (30%), Positives = 162/379 (42%), Gaps = 31/379 (8%)

Query: 267  CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEV 326
            C A G P P I W R    +S   D+ L L     L +  TQE D G+Y C+A N AGE 
Sbjct: 1092 CEAMGIPPPAIRWFRGEEPVSPGEDTYL-LAGGWMLKMTQTQEQDSGLYSCLASNEAGEA 1150

Query: 327  KTQEVTLRYFGSPARPTFVIQPQNTE----VLVGESVTLECSATGHPPPRISWTRGDRTP 382
            +      R F         I+ ++ E    VL G++  L C+ TGHP P+++W +  R P
Sbjct: 1151 R------RNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR-P 1203

Query: 383  LPVDPRVNITPSGGLYIQNVVQGD---SGEYACSATNNIDSVHATAFIIVQALPQFTVTP 439
            L      +I+P G L    V+Q +   +G Y+C A N +        + V   P      
Sbjct: 1204 LARGDAHHISPDGVLL--QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGA 1261

Query: 440  QDRV-----VIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT--LRISGV 492
            +D       V     +   CEA   P P I W K G+     R ++ L  GT  L+I   
Sbjct: 1262 EDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASR-NIQLLPGTHGLQILNA 1320

Query: 493  ALHDQGQYECQAVNIIGSQKVVAHLTV--QPRVT---PVFASIPSDTTVEVGANVQLPCS 547
               D GQY C   N +G      H+ V   P ++   P+      +   +V + + L C 
Sbjct: 1321 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECE 1380

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVS 606
            S   P P I W KDG  VT S +  +  EG  L I     +D+GRY CVA N  G     
Sbjct: 1381 SWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQD 1440

Query: 607  MVLSVNVPDVSRNGDPFVA 625
              + + VP + +    F A
Sbjct: 1441 FNVLIQVPPMFQKVGDFSA 1459



 Score =  141 bits (355), Expect = 5e-33
 Identities = 109/393 (27%), Positives = 162/393 (41%), Gaps = 30/393 (7%)

Query: 250  SEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQE 309
            S  ++  VT  N +   C A   P P I W+++        + +L L     L I N Q+
Sbjct: 1264 SADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL-LPGTHGLQILNAQK 1322

Query: 310  TDQGIYQCMAKNVAGE-VKTQEVTLRYFGSPAR--PTFVIQPQNTEVLVGESVTLECSAT 366
             D G Y C+  N  GE VK   V +    S ++  P   +  +  +  V  ++TLEC + 
Sbjct: 1323 EDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW 1382

Query: 367  GHPPPRISWTRGDRTPLPVDPRVNITPSGGLY-IQNVVQGDSGEYACSATNNIDSVHATA 425
              PPP I W + D  P+    R+ +   G L  IQ     DSG Y C ATN         
Sbjct: 1383 AVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1441

Query: 426  FIIVQALPQFTVT--------------------PQDRVVIEGQTVDFQCEAKGNPPPVIA 465
             +++Q  P F                        + R ++E       C+    PPP + 
Sbjct: 1442 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1501

Query: 466  WTKGGSQLSVDRRHLVLSSG-TLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV--QPR 522
            W +    LS      VL  G  L+I  V   + G+Y C+A N +G   +   L V   P 
Sbjct: 1502 WYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPV 1561

Query: 523  VTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEG-FLTI 581
            +      +  + TV   + V L C + G P P I+W ++G+  + S +  +  +G  L +
Sbjct: 1562 ILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQV 1621

Query: 582  NDVGPADAGRYECVARNTIGSASVSMVLSVNVP 614
            +    ADA  Y CVA N  GSA     L V VP
Sbjct: 1622 STAEVADAASYMCVAENQAGSAEKLFTLRVQVP 1654



 Score =  137 bits (345), Expect = 8e-32
 Identities = 122/458 (26%), Positives = 189/458 (41%), Gaps = 32/458 (6%)

Query: 212  ESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEG 271
            ++G        E    ++   V  + P  ++ + P      ++      +T+   C +  
Sbjct: 1324 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWA 1383

Query: 272  NPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM-IQNTQETDQGIYQCMAKNVAGE----- 325
             P P I W ++   ++    SRL +L +G L+ IQ TQ +D G Y C+A NVAGE     
Sbjct: 1384 VPPPTIRWYKDGQPVT--PSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDF 1441

Query: 326  -VKTQEVTLRYFGSPARPTFVIQPQNTE----------VLVGESVTLECSATGHPPPRIS 374
             V  Q   +          F I  +  E          ++      L C     PPP ++
Sbjct: 1442 NVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLT 1501

Query: 375  WTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNI--DSVHATAFIIVQA 431
            W R D+ PL     V++   G  L I  V   ++G Y+C A+N +  D +H    ++   
Sbjct: 1502 WYREDQ-PLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPP 1560

Query: 432  --LPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSG-TLR 488
              L       ++  V    TV  QC A GNP P I+W + G   S   R  VL  G  L+
Sbjct: 1561 VILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQ 1620

Query: 489  ISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP-SDTTVEVGANVQLPCS 547
            +S   + D   Y C A N  GS + +  L VQ  V P  A +     T  + ++V LPC 
Sbjct: 1621 VSTAEVADAASYMCVAENQAGSAEKLFTLRVQ--VPPRIAGLDLEQVTAILNSSVSLPCD 1678

Query: 548  SQGEPEPAITWNKDGVQVTESGKFHISP-EGFLTINDVGPADAGRYECVARNTIGSASVS 606
                P P +TW KD   ++   +  + P    L +     +D+G Y C A N  G     
Sbjct: 1679 VHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKL 1738

Query: 607  MVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRT 644
            + LSV VP   R        +++  +   D+A+ S  T
Sbjct: 1739 VQLSVLVPPAFRQAPRGPQDAVLVRVG--DKAVLSCET 1774



 Score =  132 bits (333), Expect = 2e-30
 Identities = 88/279 (31%), Positives = 127/279 (45%), Gaps = 15/279 (5%)

Query: 246  PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMI 304
            P  T+ P D  +  G+ ++  C A G+P P I W  N+  ++     +    D G TL  
Sbjct: 2847 PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQ----DGGSTLQR 2902

Query: 305  QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLV---GESVTL 361
                  D G Y C A+N  G  +TQ V+  +     +   V+Q +    LV   G S+ L
Sbjct: 2903 AAVSREDSGTYVCWAENRVG--RTQAVSFVH----VKEAPVLQGEAFSYLVEPVGGSIQL 2956

Query: 362  ECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV 421
            +C   G P P I W + D  PL      +   +G L I+   + D+G Y C A N +   
Sbjct: 2957 DCVVRGDPVPDIHWIK-DGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVA 3015

Query: 422  HATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLV 481
                 +++Q+ P F V PQD  V  G  V  +C+A G P P I W + G  L   RR   
Sbjct: 3016 KKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRT 3075

Query: 482  LSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ 520
            L  G+L +  V   D G Y+C A N++GS    A L V+
Sbjct: 3076 LPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114



 Score =  130 bits (326), Expect = 1e-29
 Identities = 110/382 (28%), Positives = 162/382 (42%), Gaps = 42/382 (10%)

Query: 260 GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
           G  +   C+A G+P P I WL+N          ++      TL I + +    G++ C A
Sbjct: 422 GQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQV-ASQGTTLHIDHVELDHSGLFACQA 480

Query: 320 KNVAGEVKTQ-EVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRG 378
            N AG    + EV++    +P     V++    +   G        A   PP    W   
Sbjct: 481 TNEAGTAGAEVEVSVHGEWAPG----VLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAH 536

Query: 379 DRTPL-------------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATA 425
            + PL             P    V  +    L I+ V   D G Y C+ATN         
Sbjct: 537 PKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREV 596

Query: 426 FIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKG--------GSQLSVDR 477
            + V   P     P ++ V+E  +V  +C A G PPP ++W KG        G  +SVD 
Sbjct: 597 ALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG 656

Query: 478 RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV--VAHLTVQPRVTPVFASIPSDTT 535
           R        LRI    L D G Y C A N+ GS ++     + V PR+T +  S+P    
Sbjct: 657 R-------VLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRIT-LPPSLPG--P 706

Query: 536 VEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGK--FHISPEG-FLTINDVGPADAGRY 592
           V V   V+L C++ G P P + W KDG  V+ +G     + P G  LT+     +D+GRY
Sbjct: 707 VLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRY 766

Query: 593 ECVARNTIGSASVSMVLSVNVP 614
            CVA + +G     +VL V++P
Sbjct: 767 SCVAVSAVGEDRQDVVLQVHMP 788



 Score =  121 bits (304), Expect = 4e-27
 Identities = 101/365 (27%), Positives = 162/365 (44%), Gaps = 19/365 (5%)

Query: 259 SGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDG-TLMIQNTQETDQGIYQC 317
           +G  V   C   G P P++ W ++   + +     L + +DG  L I  +   D+G YQC
Sbjct: 140 AGADVELQCWTSGVPTPQVEWTKDRQPV-LPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 198

Query: 318 MAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGES--VTLECSATGHPPPRISW 375
           +A + AG+ + ++  LR     A PT     +  EV V E   V L C A G P P I+W
Sbjct: 199 VAFSPAGQ-QARDFQLRVH---APPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254

Query: 376 TRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
            + D   LP   +V  T  G  L +      D+G Y C A+N + +      + V   P 
Sbjct: 255 FK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPT 313

Query: 435 FTVT---PQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGT-LRIS 490
                  P     + G+ V  +C A+G+P P ++W   G  ++      + + G+ LR+ 
Sbjct: 314 IEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLE 373

Query: 491 GVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP--VFASIPSDTTVEVGANVQLPCSS 548
                  G Y C A +  G  + V   +V+ +V P  + A      T  VG  ++LPC +
Sbjct: 374 SPGEASSGLYSCVASSPAG--EAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 431

Query: 549 QGEPEPAITWNKDGVQVTESGKFHISPEG-FLTINDVGPADAGRYECVARNTIGSASVSM 607
            G P P I W ++G    E     ++ +G  L I+ V    +G + C A N  G+A   +
Sbjct: 432 SGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491

Query: 608 VLSVN 612
            +SV+
Sbjct: 492 EVSVH 496



 Score =  114 bits (285), Expect = 7e-25
 Identities = 60/175 (34%), Positives = 94/175 (53%), Gaps = 7/175 (4%)

Query: 260  GNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMA 319
            G ++   C   G+P P+I W+++   L ++     + L +G+L I+ T+  D G YQC+A
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDG--LPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLA 3008

Query: 320  KNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGD 379
            +N  G  K   + +      + P F ++PQ+  V  G+ V L C ATG P P I W +  
Sbjct: 3009 ENEMGVAKKVVILVLQ----SAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAG 3064

Query: 380  RTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQ 434
            + PL    R+   P G L+++NV  GD+G Y C A N + S  A AF++V+  PQ
Sbjct: 3065 Q-PLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  176 bits (445), Expect = 2e-43
 Identities = 125/387 (32%), Positives = 179/387 (46%), Gaps = 22/387 (5%)

Query: 247 RITSEPQDADVTSGNTVYFTCRAEGNPK-PEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
           R  SEP DA    G  V   C AE +   P I W ++   L++  D R   L +G+L+IQ
Sbjct: 41  RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100

Query: 306 NT-----QETDQGIYQCMAK-NVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359
           N       + D+G+YQC A    +G + ++   +   G P R  F+ Q ++    +G++V
Sbjct: 101 NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAG-PLR--FLSQTESVTAFMGDTV 157

Query: 360 TLECSATGHPPPRISWTRG--DRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNN 417
            L+C   G P P I W +   D TP+P D RV + PSG L I  +  GD G Y CSA N 
Sbjct: 158 LLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNP 217

Query: 418 IDSVHAT-AFIIVQALP------QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
             S     A + + + P       F   P + V IEG+    +C   G PPP   W +G 
Sbjct: 218 ASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGE 277

Query: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
             + +  +++ +L    L IS V   D G Y C       +    A LTV   V P F +
Sbjct: 278 EVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--VPPWFLN 335

Query: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADA 589
            PS+       +++  C+  G+P P + W K+G  V  S  F I     L I  V  +D 
Sbjct: 336 HPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDE 395

Query: 590 GRYECVARNTIGSASVSMVLSVNVPDV 616
           G Y+CVA N  G+A  S  L V  P +
Sbjct: 396 GFYQCVAENEAGNAQTSAQLIVPKPAI 422



 Score =  159 bits (401), Expect = 2e-38
 Identities = 89/290 (30%), Positives = 132/290 (45%), Gaps = 4/290 (1%)

Query: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELS-MKTDSRLNLLDDGTLMIQ 305
           R  S+ +      G+TV   C   G P P I W +N  +L+ +  DSR+ +L  G L I 
Sbjct: 141 RFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQIS 200

Query: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPA---RPTFVIQPQNTEVLVGESVTLE 362
             Q  D GIY+C A+N A      E  +R    P    +  F+ +P N   + G+   LE
Sbjct: 201 RLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLE 260

Query: 363 CSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVH 422
           C  +G+PPP  +W RG+        + ++     L I NV   DSG Y C  T   +++ 
Sbjct: 261 CCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENIS 320

Query: 423 ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVL 482
           A+A + V   P F   P +    E   ++F+C   G P P + W K G  +       ++
Sbjct: 321 ASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIV 380

Query: 483 SSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPS 532
               LRI GV   D+G Y+C A N  G+ +  A L V     P  + +PS
Sbjct: 381 GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPS 430



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 25/103 (24%), Positives = 44/103 (42%), Gaps = 4/103 (3%)

Query: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
           P   + P +        + F C   G P P + W++N + +         ++    L I 
Sbjct: 331 PWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVI--PSDYFQIVGGSNLRIL 388

Query: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQP 348
              ++D+G YQC+A+N AG  +T    +     PA P+  + P
Sbjct: 389 GVVKSDEGFYQCVAENEAGNAQTSAQLI--VPKPAIPSSSVLP 429


>gi|139948432 adlican [Homo sapiens]
          Length = 2828

 Score =  171 bits (434), Expect = 4e-42
 Identities = 123/394 (31%), Positives = 185/394 (46%), Gaps = 30/394 (7%)

Query: 244  ERPRI-TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRL---NLLDD 299
            E+P+I T  PQ   VT+     F C A G PKP + W + +    M  ++R+    +L +
Sbjct: 1851 EKPQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKN 1910

Query: 300  GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESV 359
            GTL+I+  Q  D+G Y C A N+ G    + V L               Q+  V +G+++
Sbjct: 1911 GTLVIRKVQVQDRGQYMCTASNLHG--LDRMVVLLSVTVQQPQILASHYQDVTVYLGDTI 1968

Query: 360  TLECSATGHPPPRISWTRGDR----TPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
             +EC A G P P+ISW   DR    T  PV+ R+ +  +  L I+     D G Y C A+
Sbjct: 1969 AMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVAS 2028

Query: 416  NNIDSVHATAFIIVQALPQFTVTPQDRV----VIEGQTVDFQCEAKGNPPPVIAWTKG-G 470
            N   +      + V ALP   V  Q+++    +  G ++   C AK  P P + W  G G
Sbjct: 2029 NAAGADSLAIRLHVAALP--PVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG 2086

Query: 471  SQLSVDR----RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRV--T 524
            +Q+   +       V  +GTL I  +A  D G+YEC A N++GS +    L VQ      
Sbjct: 2087 TQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANA 2146

Query: 525  PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES-----GKFHISPEGFL 579
             +  + P  T V  G  ++L CS+ G+P P I W     ++ ++      +  +   G L
Sbjct: 2147 RITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTL 2206

Query: 580  TINDVGPADAGRYECVARNTIGSASVSMVLSVNV 613
             +  V   DAG Y CVARN +G   V  VL V+V
Sbjct: 2207 VVKSVTDKDAGDYLCVARNKVGDDYV--VLKVDV 2238



 Score =  161 bits (407), Expect = 5e-39
 Identities = 114/414 (27%), Positives = 195/414 (47%), Gaps = 32/414 (7%)

Query: 253  QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNEL---SMKTDSRLNLLDDGTLMIQNTQE 309
            ++  +  G +++  C A+  P P + W+  +      S      L +  +GTL I+N   
Sbjct: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114

Query: 310  TDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGH 368
             D G Y+C+A N+ G  + T ++ ++   + AR T    P+ T+V  G ++ L+CSA+G 
Sbjct: 2115 KDSGRYECVAANLVGSARRTVQLNVQRAAANARITGT-SPRRTDVRYGGTLKLDCSASGD 2173

Query: 369  PPPRISWTRGDRTPLPV----DPRVNITPSGGLYIQNVVQGDSGEYACSATNNI--DSVH 422
            P PRI W    +  +      D R+ +  +G L +++V   D+G+Y C A N +  D V 
Sbjct: 2174 PWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVV 2233

Query: 423  ATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL--------- 473
                ++++          D  V  G  +   C A G P P I+W+     L         
Sbjct: 2234 LKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDD 2293

Query: 474  --SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIP 531
                 +R++V ++GTL  + V + ++G Y C A N +G  +    + V+ +V    A+I 
Sbjct: 2294 SGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE----MRVRVKVVTAPATIR 2349

Query: 532  SDTTVEV----GANVQLPCSSQGEPEPAITWNKDGVQV--TESGKFHISPEGFLTINDVG 585
            + T + V    G  V + C ++GEP P +TW     +V  T S K+ I  +G L I    
Sbjct: 2350 NKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409

Query: 586  PADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAI 639
             +D+G Y C+ RN+ G    ++ + VNV     NG+P   T++ E  A   R +
Sbjct: 2410 RSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKL 2463



 Score =  160 bits (405), Expect = 8e-39
 Identities = 120/406 (29%), Positives = 189/406 (46%), Gaps = 33/406 (8%)

Query: 244  ERPRI-TSEPQDADVTSGNTVYFTCRAEGNPKPEIIWL---RNNNELSMKTDSRLNLLDD 299
            ++P+I  S  QD  V  G+T+   C A+G P P+I W+   R   +     + R+ L ++
Sbjct: 1948 QQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHEN 2007

Query: 300  GTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQP-QNTEVLVGES 358
             TL I+    +D+G+Y+C+A N AG      + +R   +   P    +  +N  +  G S
Sbjct: 2008 RTLSIKEASFSDRGVYKCVASNAAG---ADSLAIRLHVAALPPVIHQEKLENISLPPGLS 2064

Query: 359  VTLECSATGHPPPRISWTRGDRTPLPVDPRVN----ITPSGGLYIQNVVQGDSGEYACSA 414
            + + C+A   P P + W  GD T +     ++    + P+G LYI+N+   DSG Y C A
Sbjct: 2065 IHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVA 2124

Query: 415  TNNIDSVHATAFIIVQ---ALPQFTVTPQDRVVIE-GQTVDFQCEAKGNPPPVIAWTKGG 470
             N + S   T  + VQ   A  + T T   R  +  G T+   C A G+P P I W    
Sbjct: 2125 ANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPS 2184

Query: 471  SQL-----SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP 525
             ++     S D R  V ++GTL +  V   D G Y C A N +G   VV  + V  +   
Sbjct: 2185 KRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAK 2244

Query: 526  VFASIPSDTTVEVGANVQLPCSSQGEPEPAITWN-KDG------VQVTESG----KFHIS 574
            +     +D  V  G ++++ C + G P P I+W+  DG      +Q  +SG    ++ + 
Sbjct: 2245 IEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVF 2304

Query: 575  PEGFLTINDVGPADAGRYECVARNTIGSASVSM-VLSVNVPDVSRN 619
              G L  N+VG  + G Y C A N +G   + + V  V  P   RN
Sbjct: 2305 NNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRN 2350



 Score =  131 bits (330), Expect = 4e-30
 Identities = 103/395 (26%), Positives = 168/395 (42%), Gaps = 32/395 (8%)

Query: 257  VTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQ 316
            V  G+ V   C A+G P P++ WL   N++   +  +  +  DGTL+IQ  Q +D G Y 
Sbjct: 2358 VPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYT 2417

Query: 317  CMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNT--EVLVGESVTL-ECSATGHPPPRI 373
            C+ +N AGE + + V +     P +      P  T  E+  G S  L +C A G P PR+
Sbjct: 2418 CLVRNSAGEDR-KTVWIHVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRV 2476

Query: 374  SWTRGDRTPLPV---DPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV- 429
             W   +   LP      R+ +  +G L I+++ + DS +  C A N          + V 
Sbjct: 2477 LWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVL 2536

Query: 430  --QALPQFTVTPQDRV-VIEGQTVDFQCEAKGNPPPVIAWT-------KGGSQLSVDRRH 479
                 P F     +++  + G T+   C A G P P + W        + G QL   +R 
Sbjct: 2537 EPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQL---QRF 2593

Query: 480  LVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTV--QPRVTPVFASIPSDTTVE 537
               + G L ISG++  D G Y C A N  G  + +  L V  +P     + ++ S   + 
Sbjct: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVS---II 2650

Query: 538  VGANVQLPCSSQGEPEPAITWNKDGVQVTES----GKFHISPEGFLTINDVGPADAGRYE 593
             G  ++LPC+  G  +   +W        E     G+  +   G LT+ +    D G Y 
Sbjct: 2651 NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYV 2710

Query: 594  CVARNTIGSA--SVSMVLSVNVPDVSRNGDPFVAT 626
            C      G +  S+ +++    P ++    P + T
Sbjct: 2711 CRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYT 2745



 Score =  122 bits (305), Expect = 3e-27
 Identities = 105/401 (26%), Positives = 170/401 (42%), Gaps = 38/401 (9%)

Query: 241  LNCERPRITSEPQDADVT-----SGNTVYFTCRAEGNPKPEIIWLRNNNEL--SMKTDSR 293
            +N + P+I   P            G+     C+AEG P P ++W      +  +    +R
Sbjct: 2435 VNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNR 2494

Query: 294  LNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ-PQNTE 352
            + +  +G+L I++ +++D     CMA+N  GE +   + L       +P F     +   
Sbjct: 2495 ITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLI-LQLTVLEPMEKPIFHDPISEKIT 2553

Query: 353  VLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNI---TPSGGLYIQNVVQGDSGE 409
             + G +++L CSA G P P + W   + T L    ++        G L+I  +   D+G 
Sbjct: 2554 AMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGA 2613

Query: 410  YACSATNNIDSVHATAFIIVQALPQFTVTPQDRV-VIEGQTVDFQCEAKGNPPPVIAWT- 467
            Y C A N          + V   P+      + V +I G+T+   C   G      +WT 
Sbjct: 2614 YRCVARNAAGHTERLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTL 2673

Query: 468  KGGSQLSVDR---RHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV---VAHLTVQP 521
              G  L   +   R  +L +GTL +   ++ D+G Y C+     G       V  +   P
Sbjct: 2674 PNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPP 2733

Query: 522  RVT----PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWN-------KDGVQVTESGK 570
            R+T    PV  + P +T       V+L C + G P+  ITW        K GVQ    G 
Sbjct: 2734 RITSEPTPVIYTRPGNT-------VKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGN 2786

Query: 571  FHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
              + P+G LTI      DAG Y+C+A+N +GS S +  + V
Sbjct: 2787 RFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827



 Score =  100 bits (250), Expect = 8e-21
 Identities = 76/247 (30%), Positives = 118/247 (47%), Gaps = 11/247 (4%)

Query: 376  TRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF 435
            T    T L   P V+ T S   +I + VQ     +  S+        A+ F  +   PQ 
Sbjct: 1796 TGSPSTNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI 1855

Query: 436  -TVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK--GGSQLSVD---RRHLVLSSGTLRI 489
             T +PQ   V       F CEA G P P + WTK   G+ ++ +   +R  VL +GTL I
Sbjct: 1856 LTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVI 1915

Query: 490  SGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQ 549
              V + D+GQY C A N+ G  ++V  L+V  +   + AS   D TV +G  + + C ++
Sbjct: 1916 RKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975

Query: 550  GEPEPAITWNKDGVQVTES-----GKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
            G P P I+W     +V ++     G+  +     L+I +   +D G Y+CVA N  G+ S
Sbjct: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035

Query: 605  VSMVLSV 611
            +++ L V
Sbjct: 2036 LAIRLHV 2042



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 51/278 (18%)

Query: 22  WGTLAVVA------QKPGAGCPSRCLCF-RTTVRCMHLLLEAVPA-VAPQTSILDLRFNR 73
           WG L+VV        +    CP  C C+  + V C    L +VPA +A     ++L FN 
Sbjct: 7   WGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERINLGFNS 66

Query: 74  IREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLE----------------------- 110
           I+ +   +F  L  L  L+++ N+I  IP GA  DL                        
Sbjct: 67  IQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITGQTLQGL 126

Query: 111 -NLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQ--------HLPKLE 161
            NL  L++  N+I+ I  QAF GL SL  L+L  N +  L P +F          L  + 
Sbjct: 127 SNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYFRLSTIR 186

Query: 162 RLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLAD-------LLKTYAESG 214
            L+L  N +  L      ++  ++ L L  N   CDCE+ W  +       +LK   +  
Sbjct: 187 HLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILKCKKDKA 246

Query: 215 --NAQAAAICEYPRRIQGRSVATITPEELNCERPRITS 250
               Q  A+C  P+++    +  +  +++ C +P I S
Sbjct: 247 YEGGQLCAMCFSPKKLYKHEIHKL--KDMTCLKPSIES 282



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 60/216 (27%), Positives = 92/216 (42%), Gaps = 28/216 (12%)

Query: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNE 285
           R+ +GRS   I P           +  +D  V  G     +C  + +  P I W+  +  
Sbjct: 469 RQARGRSWVMIEPSG---------AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGS 519

Query: 286 LSMKT----DSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR 341
           +        DS+ ++L  G L I++ + +D G+YQC+A     +V+ +   + Y      
Sbjct: 520 ILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIA-----QVRDEMDRMVYRVLVQS 574

Query: 342 PTFVIQPQNTEVLV-----GESVTLECSATGHPPPRISWTRGDR---TPLPVDPRVNITP 393
           P+   QP   + +      GESVTL C+A   P   +SW   +R     L     V + P
Sbjct: 575 PS--TQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLP 632

Query: 394 SGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIV 429
           +G L I  V   DSG Y C A N   + H T  I V
Sbjct: 633 NGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 55/187 (29%), Positives = 84/187 (44%), Gaps = 20/187 (10%)

Query: 440 QDRVVIEGQTVDFQCEAKGNPPPVIAWT-KGGSQLSV-----DRRHLVLSSGTLRISGVA 493
           +D+ V+EG      C  K +  P I W    GS L       D +  +LSSG LRI  + 
Sbjct: 487 RDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSME 546

Query: 494 LHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSDTTVEVGAN----VQLPCSS 548
             D G Y+C A       ++V  + VQ P   P         TV +G N    V LPC++
Sbjct: 547 PSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPA-----EKDTVTIGKNPGESVTLPCNA 601

Query: 549 QGEPEPAITWNKDGVQV----TESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSAS 604
              PE  ++W     ++      +   ++ P G L+I  V  +D+G Y CVA N  G+  
Sbjct: 602 LAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADH 661

Query: 605 VSMVLSV 611
            ++ ++V
Sbjct: 662 FTVGITV 668



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 61/211 (28%), Positives = 88/211 (41%), Gaps = 18/211 (8%)

Query: 342 PTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV-----DPRVNITPSGG 396
           P+  +Q   T VL G    L C+      P I W   D + L       D + +I  SG 
Sbjct: 481 PSGAVQRDQT-VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW 539

Query: 397 LYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVI---EGQTVDFQ 453
           L I+++   DSG Y C A    +       ++VQ+ P      +D V I    G++V   
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLP 598

Query: 454 CEAKGNPPPVIAWTKGGSQLSVDRRHL----VLSSGTLRISGVALHDQGQYECQAVNIIG 509
           C A   P   ++W     ++  D  +     +L +GTL I  V + D G Y C AVN   
Sbjct: 599 CNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN--- 655

Query: 510 SQKVVAHLTVQPRVTPVFASIPSDTTVEVGA 540
            Q+   H TV   VT   + +PS      GA
Sbjct: 656 -QQGADHFTVGITVTKKGSGLPSKRGRRPGA 685



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 6/75 (8%)

Query: 529 SIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTES------GKFHISPEGFLTIN 582
           ++  D TV  G   QL C+ +    P+I W      + ++       KF I   G+L I 
Sbjct: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543

Query: 583 DVGPADAGRYECVAR 597
            + P+D+G Y+C+A+
Sbjct: 544 SMEPSDSGLYQCIAQ 558


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,704,617
Number of Sequences: 37866
Number of extensions: 2882403
Number of successful extensions: 18885
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 476
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 7233
Number of HSP's gapped (non-prelim): 4377
length of query: 1479
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1364
effective length of database: 13,892,928
effective search space: 18949953792
effective search space used: 18949953792
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.