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Search of human proteins with 108773804
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|108773804 Fraser syndrome 1 [Homo sapiens]
(4011 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|108773804 Fraser syndrome 1 [Homo sapiens] 8343 0.0
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 1286 0.0
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 676 0.0
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 676 0.0
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 675 0.0
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 525 e-148
gi|239755070 PREDICTED: similar to proprotein convertase subtili... 315 8e-85
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ... 313 2e-84
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ... 312 4e-84
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 217 2e-55
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 206 5e-52
gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens] 172 5e-42
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens] 145 6e-34
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 145 8e-34
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro... 139 6e-32
gi|37693519 BMP-binding endothelial regulator precursor protein ... 138 1e-31
gi|20336180 paired basic amino acid cleaving system 4 isoform b ... 130 3e-29
gi|4505577 paired basic amino acid cleaving system 4 isoform a p... 129 8e-29
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 124 1e-27
gi|20336182 paired basic amino acid cleaving system 4 isoform g ... 117 2e-25
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 117 2e-25
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 117 3e-25
gi|20336184 paired basic amino acid cleaving system 4 isoform h ... 117 3e-25
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 110 2e-23
gi|30089980 chordin [Homo sapiens] 107 3e-22
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 102 6e-21
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 94 3e-18
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 92 1e-17
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 92 1e-17
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 92 1e-17
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 8343 bits (21648), Expect = 0.0
Identities = 4011/4011 (100%), Positives = 4011/4011 (100%)
Query: 1 MGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKP 60
MGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKP
Sbjct: 1 MGVLKVWLGLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKP 60
Query: 61 AVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNH 120
AVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNH
Sbjct: 61 AVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNH 120
Query: 121 GEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKC 180
GEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKC
Sbjct: 121 GEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKC 180
Query: 181 LCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACT 240
LCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACT
Sbjct: 181 LCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACT 240
Query: 241 TCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG 300
TCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG
Sbjct: 241 TCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG 300
Query: 301 SACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSS 360
SACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSS
Sbjct: 301 SACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSS 360
Query: 361 NASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVH 420
NASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVH
Sbjct: 361 NASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVH 420
Query: 421 CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLE 480
CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLE
Sbjct: 421 CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLE 480
Query: 481 CSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRD 540
CSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRD
Sbjct: 481 CSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRD 540
Query: 541 GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYAD 600
GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYAD
Sbjct: 541 GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYAD 600
Query: 601 ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCL 660
ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCL
Sbjct: 601 ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCL 660
Query: 661 ACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFR 720
ACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFR
Sbjct: 661 ACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFR 720
Query: 721 CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCY 780
CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCY
Sbjct: 721 CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCY 780
Query: 781 PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD 840
PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD
Sbjct: 781 PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD 840
Query: 841 HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYL 900
HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYL
Sbjct: 841 HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYL 900
Query: 901 DDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDW 960
DDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDW
Sbjct: 901 DDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDW 960
Query: 961 SCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECTRC 1020
SCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECTRC
Sbjct: 961 SCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECTRC 1020
Query: 1021 KGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVY 1080
KGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVY
Sbjct: 1021 KGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVY 1080
Query: 1081 NCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFH 1140
NCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFH
Sbjct: 1081 NCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFH 1140
Query: 1141 VVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQF 1200
VVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQF
Sbjct: 1141 VVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQF 1200
Query: 1201 FSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEIIDPPL 1260
FSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEIIDPPL
Sbjct: 1201 FSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEIIDPPL 1260
Query: 1261 HGQLLQTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSFHNILFQVK 1320
HGQLLQTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSFHNILFQVK
Sbjct: 1261 HGQLLQTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSFHNILFQVK 1320
Query: 1321 TVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVL 1380
TVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVL
Sbjct: 1321 TVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVL 1380
Query: 1381 LVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSAS 1440
LVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSAS
Sbjct: 1381 LVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSAS 1440
Query: 1441 NAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKI 1500
NAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKI
Sbjct: 1441 NAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKI 1500
Query: 1501 VYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
VYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL
Sbjct: 1501 VYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
Query: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVR 1620
PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVR
Sbjct: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVR 1620
Query: 1621 DAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTRE 1680
DAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTRE
Sbjct: 1621 DAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTRE 1680
Query: 1681 DSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDD 1740
DSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDD
Sbjct: 1681 DSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDD 1740
Query: 1741 SSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLV 1800
SSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLV
Sbjct: 1741 SSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLV 1800
Query: 1801 TDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATD 1860
TDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATD
Sbjct: 1801 TDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATD 1860
Query: 1861 DDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVH 1920
DDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVH
Sbjct: 1861 DDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVH 1920
Query: 1921 ESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSL 1980
ESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSL
Sbjct: 1921 ESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSL 1980
Query: 1981 SLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYV 2040
SLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYV
Sbjct: 1981 SLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYV 2040
Query: 2041 PSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH 2100
PSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH
Sbjct: 2041 PSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH 2100
Query: 2101 LKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH 2160
LKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH
Sbjct: 2101 LKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH 2160
Query: 2161 GTGEPGGSFAFKFDVVDGEGNRLIDKSFSISILEDKSPPVITTNKGLVLDENSVKKITTL 2220
GTGEPGGSFAFKFDVVDGEGNRLIDKSFSISILEDKSPPVITTNKGLVLDENSVKKITTL
Sbjct: 2161 GTGEPGGSFAFKFDVVDGEGNRLIDKSFSISILEDKSPPVITTNKGLVLDENSVKKITTL 2220
Query: 2221 QLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEK 2280
QLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEK
Sbjct: 2221 QLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEK 2280
Query: 2281 HSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDAD 2340
HSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDAD
Sbjct: 2281 HSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDAD 2340
Query: 2341 TEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTF 2400
TEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTF
Sbjct: 2341 TEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTF 2400
Query: 2401 TVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNL 2460
TVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNL
Sbjct: 2401 TVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNL 2460
Query: 2461 ITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHK 2520
ITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHK
Sbjct: 2461 ITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHK 2520
Query: 2521 EKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNL 2580
EKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNL
Sbjct: 2521 EKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNL 2580
Query: 2581 NQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFEN 2640
NQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFEN
Sbjct: 2581 NQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDDDVFEN 2640
Query: 2641 VESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGD 2700
VESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGD
Sbjct: 2641 VESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPIERKGD 2700
Query: 2701 ASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDS 2760
ASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDS
Sbjct: 2701 ASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVMLIDDS 2760
Query: 2761 EYEEEEEFEIALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPV 2820
EYEEEEEFEIALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPV
Sbjct: 2761 EYEEEEEFEIALADASDNARIGRVATAKVLISGPNDASTVSLGNTAFTVSEDAGTVKIPV 2820
Query: 2821 IRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYP 2880
IRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYP
Sbjct: 2821 IRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDDTQYP 2880
Query: 2881 VIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPI 2940
VIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPI
Sbjct: 2881 VIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEGVLHVPI 2940
Query: 2941 TRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFE 3000
TRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFE
Sbjct: 2941 TRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIHDDSMFE 3000
Query: 3001 PEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAIA 3060
PEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAIA
Sbjct: 3001 PEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPAGPDAIA 3060
Query: 3061 ILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNED 3120
ILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNED
Sbjct: 3061 ILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNED 3120
Query: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEV 3180
REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEV
Sbjct: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEEV 3180
Query: 3181 TKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGA 3240
TKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGA
Sbjct: 3181 TKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGA 3240
Query: 3241 RSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIVTIGTDS 3300
RSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIVTIGTDS
Sbjct: 3241 RSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIVTIGTDS 3300
Query: 3301 AICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLH 3360
AICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLH
Sbjct: 3301 AICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLH 3360
Query: 3361 NLHFLLSESIYRHQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGPGYDRPFQFDPSVR 3420
NLHFLLSESIYRHQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGPGYDRPFQFDPSVR
Sbjct: 3361 NLHFLLSESIYRHQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGPGYDRPFQFDPSVR 3420
Query: 3421 EPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVS 3480
EPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVS
Sbjct: 3421 EPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVS 3480
Query: 3481 YIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIE 3540
YIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIE
Sbjct: 3481 YIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIE 3540
Query: 3541 FKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFDSPHQLWRATSSY 3600
FKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFDSPHQLWRATSSY
Sbjct: 3541 FKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFDSPHQLWRATSSY 3600
Query: 3601 NRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYS 3660
NRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYS
Sbjct: 3601 NRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAFQQTNRPVPVVYS 3660
Query: 3661 LNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQL 3720
LNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQL
Sbjct: 3661 LNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLNSAYKLQL 3720
Query: 3721 EKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRNQPEVTDKYFHDV 3780
EKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRNQPEVTDKYFHDV
Sbjct: 3721 EKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRNQPEVTDKYFHDV 3780
Query: 3781 PFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQ 3840
PFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQ
Sbjct: 3781 PFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDTISGPRVQ 3840
Query: 3841 RSLTAPLRRNRRDLVEPDGQLILDDSLIYDNEGDQVKNGTNMKSLNLEMQELAVAASLSQ 3900
RSLTAPLRRNRRDLVEPDGQLILDDSLIYDNEGDQVKNGTNMKSLNLEMQELAVAASLSQ
Sbjct: 3841 RSLTAPLRRNRRDLVEPDGQLILDDSLIYDNEGDQVKNGTNMKSLNLEMQELAVAASLSQ 3900
Query: 3901 TGASIGSALAAIMLLLLVFLVACFINRKCQKQRKKKPAEDILEEYPLNTKVEVPKRHPDR 3960
TGASIGSALAAIMLLLLVFLVACFINRKCQKQRKKKPAEDILEEYPLNTKVEVPKRHPDR
Sbjct: 3901 TGASIGSALAAIMLLLLVFLVACFINRKCQKQRKKKPAEDILEEYPLNTKVEVPKRHPDR 3960
Query: 3961 VEKNVNRHYCTVRNVNILSEPEAAYTFKGAKVKRLNLEVRVHNNLQDGTEV 4011
VEKNVNRHYCTVRNVNILSEPEAAYTFKGAKVKRLNLEVRVHNNLQDGTEV
Sbjct: 3961 VEKNVNRHYCTVRNVNILSEPEAAYTFKGAKVKRLNLEVRVHNNLQDGTEV 4011
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 1286 bits (3327), Expect = 0.0
Identities = 902/2761 (32%), Positives = 1376/2761 (49%), Gaps = 140/2761 (5%)
Query: 1124 LLNVQDQEGRVEDLLFHVVSTPTNGQ-LVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHS 1182
+L +D E + L+F++ S GQ ++S + + + L F+ +D+ K+ +
Sbjct: 342 MLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDRSLPLSS---FTQRDLRLLKIAYQPP 398
Query: 1183 KEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGERATIT 1236
E + LF L++ D + S+P ++ ++ +T AP V RN L + G+ +T
Sbjct: 399 SEDSDQERLFELELEVVDLEGAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLT 458
Query: 1237 ------TQMLDIRDDDNPQDVVIEIIDPPLHGQL-LQTLQSPATPIYQFQLDELSRGLLH 1289
Q L I D+D+ + V +E++ HG L + S ++ F + EL+ G +
Sbjct: 459 GPAGSGPQNLVISDEDDLEAVRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVV 518
Query: 1290 YAHDGSD-STSDVAVLQANDGHSFHNI--LFQVKTVPQNDRGLQLVANSMVWVPEGGMLQ 1346
Y HD D S SD VL+ DG H + LF + VP +D+ L AN+ + + EG +
Sbjct: 519 YQHDDRDGSLSDNLVLRMVDGGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVP 578
Query: 1347 ITNRILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPAD--EGQHLPDGRTATP 1404
I L A + +++ + + G ++L P + G +G
Sbjct: 579 ILPLSLSATDMDSDDSLLLFVLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
Query: 1405 TST-FTQQDINEGIVWYRHSGAPAQ---SDSFRFEVSSASNAQTRLESHMFNIAILPQTP 1460
T T + QQDI EG ++YRHSG + +D F F V + + F I I P
Sbjct: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
Query: 1461 EAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLP--------LHPNQ 1512
P++ L M +E LT ++ L + + + ++ Y +T L
Sbjct: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
Query: 1513 GIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESV-KFHFTVS 1571
G + D+P + +FTQ IN K+ YRPP QEL G+ V +F F V
Sbjct: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPG-----QEL------GVATRVAQFQFQVE 807
Query: 1572 DGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQVVVRDAETAPKELFF 1631
D T++L P D Q P T + G ++ V D +T + F
Sbjct: 808 DRAGNVAPGTFTLYLHPVDNQPPEILNTGFTIQ-EKGHHILSETELHVNDVDTDVAHISF 866
Query: 1632 ELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDGL 1691
L + P+HG H + + G F ED+++ + Y H+G + DS + V+D
Sbjct: 867 TLTQAPKHG----HMRVSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRH 922
Query: 1692 TVTMLEVRVEVSLSEDRGPRLA--AGSSLS-ITVASKSTAIITRSHLAYVDDSSPDPEIW 1748
V + +RV V +D P L+ G+ S + V IT + + ++ + D +
Sbjct: 923 HVVPITLRVNVRPVDDEVPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLT 982
Query: 1749 IQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLV-TDSFYFS 1807
L P YG +L ++G E+ FT DI + Y+ G L DSF S
Sbjct: 983 FLLEDPPLYGEIL-VNGIPAEQ------FTQRDILEGSVVYTHTSGEIGLLPKADSFNLS 1035
Query: 1808 VSDMDH------NHLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDD 1861
+SDM N + + I P ++ P I + + V EG ++ ++ H A +D
Sbjct: 1036 LSDMSQEWRIGGNTIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISA-ED 1094
Query: 1862 DDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHE 1921
D+L D + + P G +EN A ++F ++D+ + +I Y QSVH+
Sbjct: 1095 VDSLNDDILCTIVIQPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHK 1154
Query: 1922 SIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVISNSSLS 1981
+EP D F F SDG + SE I I NDE P M ++ V +VI L+
Sbjct: 1155 GVEPVEDRFVFRCSDGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILN 1214
Query: 1982 LQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYVP 2041
D D P ++L F +T+ P HGH++ L NG VLV+ T Q I + + Y
Sbjct: 1215 AADADVPLDDLTFTITQFPTHGHIM------NQLINGTVLVESFTLD-QIIESSSIIYEH 1267
Query: 2042 SVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASD-TPHLAINQGLQLSAGSVARITEQH 2100
D F LTDG H + + +P D TP + IN GL++ G I +
Sbjct: 1268 DDSETQEDSFVIKLTDGKH-SVEKTVLIIVIPVDDETPRMTINNGLEIEIGDTKIINNKI 1326
Query: 2101 LKVTDIDSDDHQVMYIMKEDPGAGRLQMMKH-GNLEQISIKGPIRSFTQADISQGQPEYS 2159
L TD+DS+D ++YI++ PG G LQ K G E I++ +FTQ ++ + +Y
Sbjct: 1327 LMATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLG---MNFTQDEVDRNLIQYV 1383
Query: 2160 HGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPPVITTNKGLVLDENSVKKI 2217
H G+ G KFDV DG N LID+ F +SI ++ P VI+ KG+ L E +
Sbjct: 1384 H-LGQEGIRDLIKFDVTDGI-NPLIDRYFYVSIGSIDIVFPDVIS--KGVSLKEGGKVTL 1439
Query: 2218 TTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSE 2277
TT LS +D +S L++ ITR P GHLE PG+ I+SFTQ L + Y+H+++
Sbjct: 1440 TTDLLSTSDLNSPDENLVFTITRAPMRGHLECTDQPGVSITSFTQLQLAGNKIYYIHTAD 1499
Query: 2278 AEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAV 2337
E D+F F ++DG + V +TF I++ VD+ PVV + V E K IT FEL
Sbjct: 1500 DEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKKPVVTIHKLVVSESENKLITPFELTVE 1559
Query: 2338 DADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR 2397
D DT + + FTI Q P HG + + FT +D+ +N +SY HDG+ S +D
Sbjct: 1560 DRDTPDKLLKFTITQVPIHGHLLFNNTRP----VMVFTKQDLNENLISYKHDGTESSEDS 1615
Query: 2398 FTFTVSDGTNP-FFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYM-DG 2455
F+FTV+DGT+ F++ + E T PQ ++ +L VD+ P+I N G L + G
Sbjct: 1616 FSFTVTDGTHTDFYVFPDTVFE--TRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATG 1673
Query: 2456 KATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIR 2515
+IT K L D D+ L + +T P+HG++ N + + FTQ D++ I
Sbjct: 1674 HLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLDKGNHSITQFTQADIDDMKIC 1733
Query: 2516 YVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQ 2575
YVL +E D F F V+D N ++ F + W+ ISF+ Y V+E + + V ++
Sbjct: 1734 YVL-REGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISFEKEYYLVNEDSKFLDVVLK 1792
Query: 2576 RTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDEREDTKSCTIVINDD 2635
R G L + + + T TA + +Q VQF+ + + + I D
Sbjct: 1793 RRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQ--------VQFNPGQTRATWRVRILSD 1844
Query: 2636 DVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPI 2695
E E+F V LS P A L T A V I D DEPT+ + Y V E G LF PI
Sbjct: 1845 GEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSVEEDVGELFIPI 1904
Query: 2696 ERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSAASRVIFGPGVTMSTCDVM 2755
R GD S + +CYT +A G+ ++ S SD+ SR S V F C ++
Sbjct: 1905 RRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFDKDEREKLCRIV 1964
Query: 2756 LIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPNDASTVSLGNTAFTVSEDAG 2814
+IDDS YEEEE F + L+ A+V ++ +D G+ ++V E AG
Sbjct: 1965 IIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFGDVEYSVDESAG 2024
Query: 2815 TVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTIL 2874
V++ V R GTDLS +SV +R +DP SA G DYV SR ++F PGV Q + IL
Sbjct: 2025 YVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPGVNMQPVRVVIL 2084
Query: 2875 DDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVPSMQFAKDLLLVKEKEG 2934
DD P +EG+E F + L A L +P +A ++IND+ D+P MQF + + E +G
Sbjct: 2085 DDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKERIYTGSESDG 2144
Query: 2935 VLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEERQNADSSRITFLKGDKVKNCTVYIH 2994
+ I R+GD+ Y SSVRCYT+ SAQVM DFEER N D+S ITFL G+ K C + +
Sbjct: 2145 QIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLPGETEKPCILELM 2204
Query: 2995 DDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATITISNDEDAPTIEFEEAAYQVREPA 3054
DD ++E E+ R+ LG P N GA +G+ N I I +D D I+F E + V EP
Sbjct: 2205 DDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIKFGETKFSVTEPK 2264
Query: 3055 GPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVE 3114
P ++ I VIR+GD ++ S VR T+DGSA SG DY+P S ++F G ++E
Sbjct: 2265 EPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHVVEIE 2324
Query: 3115 ILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADY 3174
+ + RE E+F++ L PD+ + A + +T A V I + + + P+ P +V+L Y
Sbjct: 2325 VTFDGVREMREAFTVHLKPDENMIAEM-QLTKAIVYIEEMSSMADVTFPSVPQIVSLLMY 2383
Query: 3175 DHVEEVTKEGVKKSPSPGYPLVCVTPCDPHFPRYAVMKERCSEAGINQTSVQFSWEVAAP 3234
D + +K P GYP++C+T C+P + Y C+ IN T ++ W ++AP
Sbjct: 2384 D---DTSKAKESAEPMSGYPVICITACNPKYSDYDKTGSICASENINDTLTRYRWLISAP 2440
Query: 3235 TDGNGARSPFETITDNTPFTSVNHMVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNIV 3294
+G SP + +T FTS + LDSIYF V+C A+AV+ G G L S IV
Sbjct: 2441 AGPDGVTSPMREVDFDTFFTSSKMVTLDSIYFQPGSRVQCAARAVNTNGDEGLELMSPIV 2500
Query: 3295 TIGTDSAICHTPVVAGTSRGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLI 3354
TI + +C P V G A+ F A L+Y + ++ N I ++V +PH DGMLP+I
Sbjct: 2501 TISREEGLCQ-PRVPGV---VGAEPFSAKLRYTGPEDADYTNLIKLTVTMPHIDGMLPVI 2556
Query: 3355 STMPLHNLHFLLSESIYR-HQHVCSNLVTTYDLRGISEAGFLDDVVYDSTALGPGYDRPF 3413
ST L N LS R H CSNL+ +++ + GFL D + +G Y P+
Sbjct: 2557 STRELSNFELTLSPDGTRVGNHKCSNLLDYTEVK--THYGFLTDATKNPEIIGETY--PY 2612
Query: 3414 QFDPSVREPKTIQLYKHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTV 3473
Q+ S+R T++ Y++LNL++C+W F +YYDM+EL+ CGG++ D QV + QS++T+
Sbjct: 2613 QYSLSIRGSTTLRFYRNLNLEACLWEFVSYYDMSELLADCGGTIGTDGQVLNLVQSYVTL 2672
Query: 3474 HVPLYVSYIY--VTAPRGWASLEHHTEMEFSFFYDT-VLWRTGIQT--DSVLSARLQIIR 3528
VPLYVSY++ GW + +E+ +F YDT +LW GI + ++ L L
Sbjct: 2673 RVPLYVSYVFHSPVGVGGWQHFDLKSELRLTFVYDTAILWNDGIGSPPEAELQGSLYPTS 2732
Query: 3529 IYIREDGRLVIEFKTHAKFRGQFVMEHHTLPEVKSFVLTPDHLGGIEFDLQLLWSAQTFD 3588
+ I ++GRL + FKT A+F G FV+ H S +++ DH G+ F L+L+ S T++
Sbjct: 2733 MRIGDEGRLAVHFKTEAQFHGLFVLS-HPASFTSSVIMSADH-PGLTFSLRLIRSEPTYN 2790
Query: 3589 SPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKPLACTAHAPERFLIPIAF 3648
P Q W S + +DYSG YT+ L+PCT Q + P+ C P F + I F
Sbjct: 2791 QPVQQWSFVSDFAVRDYSGTYTVKLVPCTAPSHQEY----RLPVTCNPREPVTFDLDIRF 2846
Query: 3649 QQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNP 3708
QQ + PV +SLNT+ L + + ++L D + +++ AF++G I+YGRV+ +P
Sbjct: 2847 QQVSDPVAAEFSLNTQMYLLSKKSLWLSDGSMGFGQESDV----AFAEGDIIYGRVMVDP 2902
Query: 3709 EQNLNSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRN 3768
QNL ++ +EKV+LCTG DGYVP + P +YGC+ + L +RF ++D+
Sbjct: 2903 VQNLGDSFYCSIEKVFLCTGADGYVPKYSPMNA------EYGCLADSPSLLYRFKIVDKA 2956
Query: 3769 QPEVTDKYFHDVPFEAHFASELPDFHVVSNMPGVDGFTLKVDALYKVEAGHQWYLQVIYI 3828
QPE F +V F A A + P+ ++ N PG DGF + L++V G +WY+ IY
Sbjct: 2957 QPETQATSFGNVLFNAKLAVDDPEAILLVNQPGSDGFKVDSTPLFQVALGREWYIHTIYT 3016
Query: 3829 I 3829
+
Sbjct: 3017 V 3017
Score = 265 bits (678), Expect = 5e-70
Identities = 313/1206 (25%), Positives = 495/1206 (41%), Gaps = 158/1206 (13%)
Query: 1462 APKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPLHPNQGIIEHRDHP 1521
APK S A + M + LT + P L+ ++E PS +++N+T P P QG + D
Sbjct: 317 APKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTSPFQPGQGYLVSTDDR 376
Query: 1522 HSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMV 1581
P+ FTQ D+ K+ Y+PP + L E V SD
Sbjct: 377 SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELEL----EVVDLEGAASD------PFA 426
Query: 1582 LTIHLLPSDQQLPVFQVTA--------PRLAVSPGGSTSVGLQVVVR-DAETAPKELFFE 1632
+ + P + PV R P GS L + D E E+
Sbjct: 427 FMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEAVRLEVVAG 486
Query: 1633 LRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDG-SSTREDSMEISVTDGL 1691
LR H V+L ++ P +FT ++ + Y HD + D++ + + DG
Sbjct: 487 LRH--GHLVILGASSGSSAP----KSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVDGG 540
Query: 1692 TVTMLEVRVEVSL--SEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPDPEIWI 1749
++ ++L +D+ P L A + L T+A T I L+ D S D +
Sbjct: 541 GRHQVQFLFPITLVPVDDQPPVLNANTGL--TLAEGETVPILPLSLSATDMDSDDSLLLF 598
Query: 1750 QLN--YLPSYGTLLRIS--GSEVEEL-------------SEVSNFTMEDINNKKIRYSAV 1792
L +L + LLR + E +EL V+ + +DI ++ Y
Sbjct: 599 VLESPFLTTGHLLLRQTHPPHEKQELLRGLWRKEGAFYERTVTEWQQQDITEGRLFYRHS 658
Query: 1793 FETDGHLVTDSFYFSVSDMDH---NHLDNQIFTIMITPAENPPPVIAFAD--LITVDEGG 1847
VTD F F V D +H N Q F I I P + PP + + V E
Sbjct: 659 GPHSPGPVTDQFTFRVQD-NHDPPNQSGLQRFVIRIHPVDRLPPELGSGCPLRMVVQESQ 717
Query: 1848 RAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQD 1907
PL TD D + R+ ++ P T T + P L +
Sbjct: 718 LTPLRKKWLRYTDLDTD-DRELRYTVTQSP-------TDTDENHLPAPLGTLVLT-DNPS 768
Query: 1908 VLENYIYYFQSVHESI---EPTHDI--------FSFYVSDGTSRSEIHSINITIERKNDE 1956
V+ + Q H I P ++ F F V D + + + +++
Sbjct: 769 VVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTFTLYLHPVDNQ 828
Query: 1957 PPRMTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLE 2016
PP + +Q ++S + L + D+DT + F LT+ P HGH+
Sbjct: 829 PPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHM---------RV 879
Query: 2017 NGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYT-----E 2071
+G++L G F +DI G V Y + + D ++D HV +++ E
Sbjct: 880 SGQILHVGGLFHLEDIKQGRVSYAHNGDKSLTDSCSLEVSDRHHVVPITLRVNVRPVDDE 939
Query: 2072 LPASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKH 2131
+P P + L + IT +K T+ ++DD + +++++ P G
Sbjct: 940 VPILSHPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYG------- 992
Query: 2132 GNLEQISIKG-PIRSFTQADISQGQPEYSHGTGEPG-----GSFAFKFDVVDGE----GN 2181
+I + G P FTQ DI +G Y+H +GE G SF + E GN
Sbjct: 993 ----EILVNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGN 1048
Query: 2182 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITR 2240
+ + ++IL D P I + L++ E IT++ +SA D DS +++ I
Sbjct: 1049 TIQGVTIWVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVI 1108
Query: 2241 QPQLGHLEH--------AASPGIQISSFTQADLTSRNVQYVHS--SEAEKHSDAFSFTLS 2290
QP G++E+ + GI IS+F DL ++ YV S E D F F S
Sbjct: 1109 QPTSGYVENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCS 1168
Query: 2291 DGVS-EVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKAVDADTEAESVTFT 2349
DG++ Q F I + P +D P + V EGM I L A DAD + +TFT
Sbjct: 1169 DGINFSERQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFT 1228
Query: 2350 IVQPPRHGTI-ERTSNGQHFHLTSTFTMKDIYQ-NRVSYSHDGSNSLKDRFTFTVSDGTN 2407
I Q P HG I + NG L +FT+ I + + + Y HD S + +D F ++DG +
Sbjct: 1229 ITQFPTHGHIMNQLINGT--VLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKH 1286
Query: 2408 PFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELL 2467
+ + + ++PVDD TPR+ N GL+ +E D T +I K L+
Sbjct: 1287 --------------SVEKTVLIIVIPVDDETPRMTINNGLE-IEIGD---TKIINNKILM 1328
Query: 2468 TMDPDTEDAQLVYEITTGPKHGFVENKLQPG-----RAAATFTQEDVNLGLIRYV-LHKE 2521
D D+ED LVY I GP HG ++ + G FTQ++V+ LI+YV L +E
Sbjct: 1329 ATDLDSEDKSLVYIIRYGPGHGLLQRRKPTGAFENITLGMNFTQDEVDRNLIQYVHLGQE 1388
Query: 2522 KIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKY---TSYNVSEKAG---SVSVTVQ 2575
IR+++ +F V D N + D F++ I + S VS K G +++ +
Sbjct: 1389 GIRDLI---KFDVTDG-INPLIDRYFYVSIGSIDIVFPDVISKGVSLKEGGKVTLTTDLL 1444
Query: 2576 RTGNLN 2581
T +LN
Sbjct: 1445 STSDLN 1450
Score = 160 bits (404), Expect = 3e-38
Identities = 189/758 (24%), Positives = 317/758 (41%), Gaps = 94/758 (12%)
Query: 1102 PSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQL 1161
P + V LI+ G + ++ +D + +D+L +V PT+G + +
Sbjct: 1067 PEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYVENISPAPGSEK 1126
Query: 1162 DKAG----RFSWKDVNEKKVRFVHSKEK----LRKGYLFLKISDQQFFSEPQLINIQAFS 1213
+AG F+ KD+ + + +V S K + ++F + SD FSE Q I
Sbjct: 1127 SRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVF-RCSDGINFSERQFFPIVIIP 1185
Query: 1214 T--QAPYVLRNEVLHISRGERATITTQMLDIRDDDNP-QDVVIEIIDPPLHGQLLQTLQS 1270
T + P + E + + G I T +L+ D D P D+ I P HG ++ L +
Sbjct: 1186 TNDEQPEMFMREFM-VMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTHGHIMNQLIN 1244
Query: 1271 PATPIYQFQLDE-LSRGLLHYAHDGSDSTSDVAVLQANDG-HSFHNILFQVKTVPQNDRG 1328
+ F LD+ + + Y HD S++ D V++ DG HS + + +P +D
Sbjct: 1245 GTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVL-IIVIPVDDET 1303
Query: 1329 LQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADS 1388
++ N+ + + G I N+IL A + + ++Y I ++G L+ +
Sbjct: 1304 PRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYII-----RYGPGHGLLQRRKPT 1358
Query: 1389 PADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQTRLES 1448
A E T FTQ +++ ++ Y H G D +F+V+ N L
Sbjct: 1359 GAFE--------NITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINP---LID 1407
Query: 1449 HMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPL 1508
F ++I P V S ++ +E G + LS + P +V+ IT
Sbjct: 1408 RYFYVSIGSIDIVFPDV---ISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRA- 1463
Query: 1509 HPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVK--- 1565
P +G +E D P I FTQ + K+ Y + VK
Sbjct: 1464 -PMRGHLECTDQPGVSITSFTQLQLAGNKIYY----------------IHTADDEVKMDS 1506
Query: 1566 FHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSV-GLQVVVRDAET 1624
F F V+DG + I + D + PV VT +L VS + + ++ V D +T
Sbjct: 1507 FEFQVTDGRN-PVFRTFRISISDVDNKKPV--VTIHKLVVSESENKLITPFELTVEDRDT 1563
Query: 1625 APKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSME 1684
K L F + + P HG LL + RP+ FT +D+ +N + Y HDG+ + EDS
Sbjct: 1564 PDKLLKFTITQVPIHGHLLFNNT---RPVM---VFTKQDLNENLISYKHDGTESSEDSFS 1617
Query: 1685 ISVTDGLTV-------TMLEVR------VEVSLSEDRGPRLAA--GSSLSITVASKSTAI 1729
+VTDG T+ E R ++V ++ P++A G+S T+A+
Sbjct: 1618 FTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDNSVPQIAVNKGASTLRTLATGHLGF 1677
Query: 1730 ITRSHLAYVDDSSPDPEIWIQLNYL----PSYGTLLRISGSEVEELSEVSNFTMEDINNK 1785
+ S + V+D + I L ++ P +G LL + ++ FT DI++
Sbjct: 1678 MITSKILKVEDRD---SLHISLRFIVTEAPQHGYLLNLDKGN----HSITQFTQADIDDM 1730
Query: 1786 KIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTI 1823
KI Y V + +D FYF+V D N L Q F +
Sbjct: 1731 KICY--VLREGANATSDMFYFAVEDGGGNKLTYQNFRL 1766
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 676 bits (1743), Expect = 0.0
Identities = 557/1860 (29%), Positives = 872/1860 (46%), Gaps = 128/1860 (6%)
Query: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDK-----AGRFSWKDVNEKKVRF 1179
L +D E DL+F++++ PT+ + G V D F+ +++ E K+ +
Sbjct: 330 LAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAY 389
Query: 1180 VHSKEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGE-R 1232
E LF L++ D S+P ++ +++ +T P N L + G+ R
Sbjct: 390 QPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSR 449
Query: 1233 ATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAH 1292
+T + I D DN ++V + + HGQL+ +PA Y F +L+ G + Y H
Sbjct: 450 PLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLV-VFGAPAGCKY-FTPADLAAGRVVYQH 507
Query: 1293 DGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRIL 1352
DGS++ SD + + DGH + LF + +P +D + N+ + + EG ++QI+ +L
Sbjct: 508 DGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVL 567
Query: 1353 QAEAPGASAEEIIY-------KITQDYPQF-------------GEVVLLVNMPADSPADE 1392
A + I + K ++ PQ+ G+++L S DE
Sbjct: 568 SATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDE 627
Query: 1393 GQHL--PDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSD---SFRFEVSSASNAQTRLE 1447
H +G + + Q+DI EG ++YRH G + F V + +
Sbjct: 628 DWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSK 687
Query: 1448 SHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNI-TL 1506
H+F I + P +P++ +L MT +E LT Q + L +I+ + + Y + TL
Sbjct: 688 QHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTL 747
Query: 1507 PLHPN------QGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
P + G I D P + I +FTQ +NQ KV Y+PP
Sbjct: 748 PTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQ-----------KLGIA 796
Query: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVV 1619
P V+F + V D S T+ L P D Q P +VT A+ GGS ++ ++ V
Sbjct: 797 PRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPP--EVTNRGFAILEGGSFNLSSNELHV 854
Query: 1620 RDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHD-GSST 1678
D +T ++ F L R PQHG H F+R M G++F DV ++ Y H +T
Sbjct: 855 TDPDTDIDQIVFILVRGPQHG----HLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTT 910
Query: 1679 REDSMEISVTDGLTVTMLEVRVEVSLS-EDRGPRLAAGSS----LSITVASKSTAIITRS 1733
D+ + V+DG+ + + + V + +R PR++ SS +SI V IT
Sbjct: 911 TSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMG 970
Query: 1734 HLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVF 1793
+ D + + P GT+L ++G E FT ED+ N ++ Y+
Sbjct: 971 VIHGKRKDVGDLMLSFIVKDSPKLGTIL-VNGLPTER------FTQEDLINGRVAYAHTA 1023
Query: 1794 ETDGH----------LVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITV 1843
G L DS+ + V + + Q+ + P +N P + + V
Sbjct: 1024 GEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQV---TVLPVDNVGPKVLVGESFIV 1080
Query: 1844 DEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASF 1903
EG + L+ H D D + Q + + +++ P G +E + + ++F
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTH-QDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAF 1139
Query: 1904 PIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQ 1963
++D+ +I Y QS+H+ +EP D F+FY SDG + S I I NDE P++
Sbjct: 1140 SLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAH 1199
Query: 1964 PLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWR-QTASEPLENGRVLV 2022
+V +VI L+ D D P NEL F LT P HG ++ + T S+P+ +
Sbjct: 1200 EFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHS----- 1254
Query: 2023 QGSTFTYQDIL-AGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLA 2081
FT ++I A + Y D F+ L+DG H ++ I L +TPHL
Sbjct: 1255 ----FTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLT 1310
Query: 2082 INQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKG 2141
+N GL++ G IT + LK TD+DSDD + +++ P G LQ ++ E +
Sbjct: 1311 VNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLT 1370
Query: 2142 PIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPP 2199
+FTQ +I++G Y H TG+ G KFDV DG N L D F ++I L+ P
Sbjct: 1371 LGMNFTQDEINRGLICYIH-TGQEGIVDIIKFDVTDGV-NTLTDHYFYVTIGNLDSVFPE 1428
Query: 2200 VITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISS 2259
VI+ K + L E + +T L+ +D +S E + ITR P LGHLE + G I+S
Sbjct: 1429 VIS--KRITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIAS 1485
Query: 2260 FTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGM 2319
FTQ L S + YVH+S EK D+F F + + V +TF I + VD+ P++ +
Sbjct: 1486 FTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRL 1545
Query: 2320 RVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDI 2379
+Q+ + IT EL D+DT + + FTI Q P HG I NG +TFT +D+
Sbjct: 1546 TLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKI--LYNGS--RPVTTFTKQDL 1601
Query: 2380 YQNRVSYSHDGSNSLKDRFTFTVSDGTN-PFFIIEEGGKEIMTAAPQPFRVDILPVDDGT 2438
+N +SY HDGS + +D F+ TV+DGT+ F+++ + + T PQ RV I +D+
Sbjct: 1602 NKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPD--TALATHKPQVMRVQIRSLDNRL 1659
Query: 2439 PRIVTNLGLQWLEYM-DGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQP 2497
P+I TN G L+ + G LIT K L D D+ L Y++T GP+HGF+
Sbjct: 1660 PQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLG 1719
Query: 2498 GRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFK 2557
++ FTQ D++ I YVL+ E D F F V+D+ N +++ FH+ W+ I +
Sbjct: 1720 NQSTRVFTQADIDEMKISYVLN-EGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLE 1778
Query: 2558 YTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQV 2617
Y V E + + VT+ R G L + + + T+ TA + + Q+
Sbjct: 1779 KEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNK--------QI 1830
Query: 2618 QFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEF 2677
QF+ + T + + I D+ +E E+F + LS P A+L A V I D DE T+
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYI 1890
Query: 2678 DKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSA 2737
+ Y + E G L P+ R GDAS + IC T SA G ++ + SD+ SR
Sbjct: 1891 PEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATG-TISSTVLFSDYISRPEDH 1949
Query: 2738 ASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPND 2796
S + F T TC V++IDDS YEEEE F ++L R T KV +++ D
Sbjct: 1950 TSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYD 2009
Query: 2797 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSR 2856
+ G+ + V+E A V++ V R GTDLS +S+ +R S+ SA G DYV SR
Sbjct: 2010 EPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISR 2069
Query: 2857 KVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQD 2916
++F PGV Q +TILDD P +EG E F + L GA L +P + I I DT D
Sbjct: 2070 NLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 118 bits (296), Expect = 1e-25
Identities = 113/369 (30%), Positives = 172/369 (46%), Gaps = 33/369 (8%)
Query: 2800 VSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYV-PSSRKV 2858
+ L + V ED+ +++ + R G L + + T+ +A D+ +++++
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDE---TAKKDKDFKWKTNKQI 1830
Query: 2859 EFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVP 2918
+F PG + I+ D +Y E ETF + LS A L P A + I D D
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEY---ETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDES 1886
Query: 2919 SMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQ-------VMEDFEERQ 2971
++ + ++E G L +P+ RSGD S E V C T+ SA + D+ R
Sbjct: 1887 TVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRP 1946
Query: 2972 NADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATIT 3031
+S + F K + K C V I DDS++E EE F V L LP+G GAR + +
Sbjct: 1947 EDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTILA 2005
Query: 3032 ISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRG-DQNRTSKVRCSTRDG---SA 3087
DE P + F +A Y V E A + + V RRG D ++ S + +R SA
Sbjct: 2006 DRYDE--PVLHFGDAEYHVNESA-----RYVEVCVWRRGTDLSQPSSIAVRSRKSEQESA 2058
Query: 3088 QSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDR---EWHESFSLVLGPDDPVEAVLGDV 3144
++G DY SR L F+PGV F+V IL + + E E F L+L P+ AVLG+
Sbjct: 2059 EAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL--QMPMGAVLGEP 2116
Query: 3145 TTATVTILD 3153
T+ I D
Sbjct: 2117 NKTTIFIED 2125
Score = 114 bits (285), Expect = 2e-24
Identities = 181/777 (23%), Positives = 300/777 (38%), Gaps = 150/777 (19%)
Query: 1957 PPR---MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDH-----GHVLWR 2008
PPR M + V ++ +L+ +D+++ +L+F + P H G +
Sbjct: 304 PPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYV 363
Query: 2009 QTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDE-FQFSLT----DGLHVDT 2063
+ +PL + S FT Q++ + Y P + FQ L DG D
Sbjct: 364 VSTDDPLG-----LPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDP 418
Query: 2064 GRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH-LKVTDIDSDDHQVMYIMKEDPG 2122
+ + + P + N+GL L G ++ H + ++D D+ E+
Sbjct: 419 FAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDN---------LEEVK 469
Query: 2123 AGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFKFDVVDGEGN 2181
++ ++HG L + FT AD++ G+ Y H G+ + F+ + +G+
Sbjct: 470 MAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRME----DGH 525
Query: 2182 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITR 2240
+D F ++IL D PP++ TN GL L E V +I+ LSATD DS + + + +
Sbjct: 526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLEN 585
Query: 2241 QPQLGHLEH---AASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVT 2297
QP G+ E +PG S DL + + S+E E + + +G+ E
Sbjct: 586 QPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDED----WHYMEKEGLYEKV 641
Query: 2298 QT-----------------------------------------------FHITLHPVDDS 2310
T F I + PVD
Sbjct: 642 VTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDIL 701
Query: 2311 LPVV---QNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPP---------RHGT 2358
P + L M VQE + L+ +D D++ +++ +T++ P R G
Sbjct: 702 SPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGE 761
Query: 2359 IERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR---FTFTVSDGTNPFFIIEEG 2415
I T + L FT + Q++V+Y + R FT+ V D
Sbjct: 762 IVLTDSPD--TLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAG-------- 811
Query: 2416 GKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDPDTED 2475
+ P F + + PVD+ P VTN G LE G + NL + EL DPDT+
Sbjct: 812 -----NSVPGTFTLFLQPVDNQPPE-VTNRGFAILE---GGSFNL-SSNELHVTDPDTDI 861
Query: 2476 AQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVK 2535
Q+V+ + GP+HG ++ + +F Q DV G + Y H D+F V
Sbjct: 862 DQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVS 920
Query: 2536 DS------------KPNVVSDNVFHIQWSLISFKYTSYNVSE-KAGSVSVTV-----QRT 2577
D PNV + + I S S +V E KA +++ V +
Sbjct: 921 DGVHHIPITIPISVHPNVANRSP-RISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDV 979
Query: 2578 GNLNQYAIVLCRTEQGTASSSSRVSSQPGQQD-------YVEYAGQVQFDEREDTKS 2627
G+L IV + GT + + + Q+D Y AG+V F ++ D S
Sbjct: 980 GDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFS 1036
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/103 (28%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 3062 LNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDY-YPKSRVLKFSPGVDHIFFKVEILSNED 3120
L + + RRG TS + T+D +A+ D+ + ++ ++F+PG ++V I+ + +
Sbjct: 1791 LEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNE 1850
Query: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILP 3163
E E+F ++L +P+ AVL ATV I+D ++ +P
Sbjct: 1851 YETSETFQIILS--EPLMAVLEFPEMATVEIVDPGDESTVYIP 1891
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 676 bits (1743), Expect = 0.0
Identities = 557/1860 (29%), Positives = 872/1860 (46%), Gaps = 128/1860 (6%)
Query: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDK-----AGRFSWKDVNEKKVRF 1179
L +D E DL+F++++ PT+ + G V D F+ +++ E K+ +
Sbjct: 330 LAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAY 389
Query: 1180 VHSKEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGE-R 1232
E LF L++ D S+P ++ +++ +T P N L + G+ R
Sbjct: 390 QPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSR 449
Query: 1233 ATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAH 1292
+T + I D DN ++V + + HGQL+ +PA Y F +L+ G + Y H
Sbjct: 450 PLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLV-VFGAPAGCKY-FTPADLAAGRVVYQH 507
Query: 1293 DGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRIL 1352
DGS++ SD + + DGH + LF + +P +D + N+ + + EG ++QI+ +L
Sbjct: 508 DGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVL 567
Query: 1353 QAEAPGASAEEIIY-------KITQDYPQF-------------GEVVLLVNMPADSPADE 1392
A + I + K ++ PQ+ G+++L S DE
Sbjct: 568 SATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDE 627
Query: 1393 GQHL--PDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSD---SFRFEVSSASNAQTRLE 1447
H +G + + Q+DI EG ++YRH G + F V + +
Sbjct: 628 DWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSK 687
Query: 1448 SHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNI-TL 1506
H+F I + P +P++ +L MT +E LT Q + L +I+ + + Y + TL
Sbjct: 688 QHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTL 747
Query: 1507 PLHPN------QGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
P + G I D P + I +FTQ +NQ KV Y+PP
Sbjct: 748 PTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQ-----------KLGIA 796
Query: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVV 1619
P V+F + V D S T+ L P D Q P +VT A+ GGS ++ ++ V
Sbjct: 797 PRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPP--EVTNRGFAILEGGSFNLSSNELHV 854
Query: 1620 RDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHD-GSST 1678
D +T ++ F L R PQHG H F+R M G++F DV ++ Y H +T
Sbjct: 855 TDPDTDIDQIVFILVRGPQHG----HLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTT 910
Query: 1679 REDSMEISVTDGLTVTMLEVRVEVSLS-EDRGPRLAAGSS----LSITVASKSTAIITRS 1733
D+ + V+DG+ + + + V + +R PR++ SS +SI V IT
Sbjct: 911 TSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMG 970
Query: 1734 HLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVF 1793
+ D + + P GT+L ++G E FT ED+ N ++ Y+
Sbjct: 971 VIHGKRKDVGDLMLSFIVKDSPKLGTIL-VNGLPTER------FTQEDLINGRVAYAHTA 1023
Query: 1794 ETDGH----------LVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITV 1843
G L DS+ + V + + Q+ + P +N P + + V
Sbjct: 1024 GEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQV---TVLPVDNVGPKVLVGESFIV 1080
Query: 1844 DEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASF 1903
EG + L+ H D D + Q + + +++ P G +E + + ++F
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTH-QDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAF 1139
Query: 1904 PIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQ 1963
++D+ +I Y QS+H+ +EP D F+FY SDG + S I I NDE P++
Sbjct: 1140 SLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAH 1199
Query: 1964 PLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWR-QTASEPLENGRVLV 2022
+V +VI L+ D D P NEL F LT P HG ++ + T S+P+ +
Sbjct: 1200 EFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHS----- 1254
Query: 2023 QGSTFTYQDIL-AGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLA 2081
FT ++I A + Y D F+ L+DG H ++ I L +TPHL
Sbjct: 1255 ----FTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLT 1310
Query: 2082 INQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKG 2141
+N GL++ G IT + LK TD+DSDD + +++ P G LQ ++ E +
Sbjct: 1311 VNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLT 1370
Query: 2142 PIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPP 2199
+FTQ +I++G Y H TG+ G KFDV DG N L D F ++I L+ P
Sbjct: 1371 LGMNFTQDEINRGLICYIH-TGQEGIVDIIKFDVTDGV-NTLTDHYFYVTIGNLDSVFPE 1428
Query: 2200 VITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISS 2259
VI+ K + L E + +T L+ +D +S E + ITR P LGHLE + G I+S
Sbjct: 1429 VIS--KRITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIAS 1485
Query: 2260 FTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGM 2319
FTQ L S + YVH+S EK D+F F + + V +TF I + VD+ P++ +
Sbjct: 1486 FTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRL 1545
Query: 2320 RVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDI 2379
+Q+ + IT EL D+DT + + FTI Q P HG I NG +TFT +D+
Sbjct: 1546 TLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKI--LYNGS--RPVTTFTKQDL 1601
Query: 2380 YQNRVSYSHDGSNSLKDRFTFTVSDGTN-PFFIIEEGGKEIMTAAPQPFRVDILPVDDGT 2438
+N +SY HDGS + +D F+ TV+DGT+ F+++ + + T PQ RV I +D+
Sbjct: 1602 NKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPD--TALATHKPQVMRVQIRSLDNRL 1659
Query: 2439 PRIVTNLGLQWLEYM-DGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQP 2497
P+I TN G L+ + G LIT K L D D+ L Y++T GP+HGF+
Sbjct: 1660 PQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLG 1719
Query: 2498 GRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFK 2557
++ FTQ D++ I YVL+ E D F F V+D+ N +++ FH+ W+ I +
Sbjct: 1720 NQSTRVFTQADIDEMKISYVLN-EGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLE 1778
Query: 2558 YTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQV 2617
Y V E + + VT+ R G L + + + T+ TA + + Q+
Sbjct: 1779 KEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNK--------QI 1830
Query: 2618 QFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEF 2677
QF+ + T + + I D+ +E E+F + LS P A+L A V I D DE T+
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYI 1890
Query: 2678 DKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSA 2737
+ Y + E G L P+ R GDAS + IC T SA G ++ + SD+ SR
Sbjct: 1891 PEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATG-TISSTVLFSDYISRPEDH 1949
Query: 2738 ASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPND 2796
S + F T TC V++IDDS YEEEE F ++L R T KV +++ D
Sbjct: 1950 TSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYD 2009
Query: 2797 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSR 2856
+ G+ + V+E A V++ V R GTDLS +S+ +R S+ SA G DYV SR
Sbjct: 2010 EPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISR 2069
Query: 2857 KVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQD 2916
++F PGV Q +TILDD P +EG E F + L GA L +P + I I DT D
Sbjct: 2070 NLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 118 bits (296), Expect = 1e-25
Identities = 113/369 (30%), Positives = 172/369 (46%), Gaps = 33/369 (8%)
Query: 2800 VSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYV-PSSRKV 2858
+ L + V ED+ +++ + R G L + + T+ +A D+ +++++
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDE---TAKKDKDFKWKTNKQI 1830
Query: 2859 EFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVP 2918
+F PG + I+ D +Y E ETF + LS A L P A + I D D
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEY---ETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDES 1886
Query: 2919 SMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQ-------VMEDFEERQ 2971
++ + ++E G L +P+ RSGD S E V C T+ SA + D+ R
Sbjct: 1887 TVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRP 1946
Query: 2972 NADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATIT 3031
+S + F K + K C V I DDS++E EE F V L LP+G GAR + +
Sbjct: 1947 EDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTILA 2005
Query: 3032 ISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRG-DQNRTSKVRCSTRDG---SA 3087
DE P + F +A Y V E A + + V RRG D ++ S + +R SA
Sbjct: 2006 DRYDE--PVLHFGDAEYHVNESA-----RYVEVCVWRRGTDLSQPSSIAVRSRKSEQESA 2058
Query: 3088 QSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDR---EWHESFSLVLGPDDPVEAVLGDV 3144
++G DY SR L F+PGV F+V IL + + E E F L+L P+ AVLG+
Sbjct: 2059 EAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL--QMPMGAVLGEP 2116
Query: 3145 TTATVTILD 3153
T+ I D
Sbjct: 2117 NKTTIFIED 2125
Score = 114 bits (285), Expect = 2e-24
Identities = 181/777 (23%), Positives = 300/777 (38%), Gaps = 150/777 (19%)
Query: 1957 PPR---MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDH-----GHVLWR 2008
PPR M + V ++ +L+ +D+++ +L+F + P H G +
Sbjct: 304 PPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYV 363
Query: 2009 QTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDE-FQFSLT----DGLHVDT 2063
+ +PL + S FT Q++ + Y P + FQ L DG D
Sbjct: 364 VSTDDPLG-----LPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDP 418
Query: 2064 GRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH-LKVTDIDSDDHQVMYIMKEDPG 2122
+ + + P + N+GL L G ++ H + ++D D+ E+
Sbjct: 419 FAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDN---------LEEVK 469
Query: 2123 AGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFKFDVVDGEGN 2181
++ ++HG L + FT AD++ G+ Y H G+ + F+ + +G+
Sbjct: 470 MAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRME----DGH 525
Query: 2182 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITR 2240
+D F ++IL D PP++ TN GL L E V +I+ LSATD DS + + + +
Sbjct: 526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLEN 585
Query: 2241 QPQLGHLEH---AASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVT 2297
QP G+ E +PG S DL + + S+E E + + +G+ E
Sbjct: 586 QPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDED----WHYMEKEGLYEKV 641
Query: 2298 QT-----------------------------------------------FHITLHPVDDS 2310
T F I + PVD
Sbjct: 642 VTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDIL 701
Query: 2311 LPVV---QNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPP---------RHGT 2358
P + L M VQE + L+ +D D++ +++ +T++ P R G
Sbjct: 702 SPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGE 761
Query: 2359 IERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR---FTFTVSDGTNPFFIIEEG 2415
I T + L FT + Q++V+Y + R FT+ V D
Sbjct: 762 IVLTDSPD--TLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAG-------- 811
Query: 2416 GKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDPDTED 2475
+ P F + + PVD+ P VTN G LE G + NL + EL DPDT+
Sbjct: 812 -----NSVPGTFTLFLQPVDNQPPE-VTNRGFAILE---GGSFNL-SSNELHVTDPDTDI 861
Query: 2476 AQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVK 2535
Q+V+ + GP+HG ++ + +F Q DV G + Y H D+F V
Sbjct: 862 DQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVS 920
Query: 2536 DS------------KPNVVSDNVFHIQWSLISFKYTSYNVSE-KAGSVSVTV-----QRT 2577
D PNV + + I S S +V E KA +++ V +
Sbjct: 921 DGVHHIPITIPISVHPNVANRSP-RISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDV 979
Query: 2578 GNLNQYAIVLCRTEQGTASSSSRVSSQPGQQD-------YVEYAGQVQFDEREDTKS 2627
G+L IV + GT + + + Q+D Y AG+V F ++ D S
Sbjct: 980 GDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFS 1036
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/103 (28%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 3062 LNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDY-YPKSRVLKFSPGVDHIFFKVEILSNED 3120
L + + RRG TS + T+D +A+ D+ + ++ ++F+PG ++V I+ + +
Sbjct: 1791 LEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNE 1850
Query: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILP 3163
E E+F ++L +P+ AVL ATV I+D ++ +P
Sbjct: 1851 YETSETFQIILS--EPLMAVLEFPEMATVEIVDPGDESTVYIP 1891
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 675 bits (1742), Expect = 0.0
Identities = 557/1860 (29%), Positives = 872/1860 (46%), Gaps = 128/1860 (6%)
Query: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDK-----AGRFSWKDVNEKKVRF 1179
L +D E DL+F++++ PT+ + G V D F+ +++ E K+ +
Sbjct: 330 LAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAY 389
Query: 1180 VHSKEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGE-R 1232
E LF L++ D S+P ++ +++ +T P N L + G+ R
Sbjct: 390 QPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSR 449
Query: 1233 ATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAH 1292
+T + I D DN ++V + + HGQL+ +PA Y F +L+ G + Y H
Sbjct: 450 PLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLV-VFGAPAGCKY-FTPADLAAGRVVYQH 507
Query: 1293 DGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRIL 1352
DGS++ SD + + DGH + LF + +P +D + N+ + + EG ++QI+ +L
Sbjct: 508 DGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVL 567
Query: 1353 QAEAPGASAEEIIY-------KITQDYPQF-------------GEVVLLVNMPADSPADE 1392
A + I + K ++ PQ+ G+++L S DE
Sbjct: 568 SATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDE 627
Query: 1393 GQHL--PDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSD---SFRFEVSSASNAQTRLE 1447
H +G + + Q+DI EG ++YRH G + F V + +
Sbjct: 628 DWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSK 687
Query: 1448 SHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNI-TL 1506
H+F I + P +P++ +L MT +E LT Q + L +I+ + + Y + TL
Sbjct: 688 QHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTL 747
Query: 1507 PLHPN------QGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
P + G I D P + I +FTQ +NQ KV Y+PP
Sbjct: 748 PTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQ-----------KLGIA 796
Query: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVV 1619
P V+F + V D S T+ L P D Q P +VT A+ GGS ++ ++ V
Sbjct: 797 PRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPP--EVTNRGFAILEGGSFNLSSNELHV 854
Query: 1620 RDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHD-GSST 1678
D +T ++ F L R PQHG H F+R M G++F DV ++ Y H +T
Sbjct: 855 TDPDTDIDQIVFILVRGPQHG----HLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTT 910
Query: 1679 REDSMEISVTDGLTVTMLEVRVEVSLS-EDRGPRLAAGSS----LSITVASKSTAIITRS 1733
D+ + V+DG+ + + + V + +R PR++ SS +SI V IT
Sbjct: 911 TSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMG 970
Query: 1734 HLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVF 1793
+ D + + P GT+L ++G E FT ED+ N ++ Y+
Sbjct: 971 VIHGKRKDVGDLMLSFIVKDSPKLGTIL-VNGLPTER------FTQEDLINGRVAYAHTA 1023
Query: 1794 ETDGH----------LVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITV 1843
G L DS+ + V + + Q+ + P +N P + + V
Sbjct: 1024 GEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQV---TVLPVDNVGPKVFVGESFIV 1080
Query: 1844 DEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASF 1903
EG + L+ H D D + Q + + +++ P G +E + + ++F
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTH-QDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAF 1139
Query: 1904 PIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQ 1963
++D+ +I Y QS+H+ +EP D F+FY SDG + S I I NDE P++
Sbjct: 1140 SLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAH 1199
Query: 1964 PLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWR-QTASEPLENGRVLV 2022
+V +VI L+ D D P NEL F LT P HG ++ + T S+P+ +
Sbjct: 1200 EFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHS----- 1254
Query: 2023 QGSTFTYQDIL-AGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLA 2081
FT ++I A + Y D F+ L+DG H ++ I L +TPHL
Sbjct: 1255 ----FTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLT 1310
Query: 2082 INQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKG 2141
+N GL++ G IT + LK TD+DSDD + +++ P G LQ ++ E +
Sbjct: 1311 VNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLT 1370
Query: 2142 PIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPP 2199
+FTQ +I++G Y H TG+ G KFDV DG N L D F ++I L+ P
Sbjct: 1371 LGMNFTQDEINRGLICYIH-TGQEGIVDIIKFDVTDGV-NTLTDHYFYVTIGNLDSVFPE 1428
Query: 2200 VITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISS 2259
VI+ K + L E + +T L+ +D +S E + ITR P LGHLE + G I+S
Sbjct: 1429 VIS--KRITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIAS 1485
Query: 2260 FTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGM 2319
FTQ L S + YVH+S EK D+F F + + V +TF I + VD+ P++ +
Sbjct: 1486 FTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRL 1545
Query: 2320 RVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDI 2379
+Q+ + IT EL D+DT + + FTI Q P HG I NG +TFT +D+
Sbjct: 1546 TLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKI--LYNGS--RPVTTFTKQDL 1601
Query: 2380 YQNRVSYSHDGSNSLKDRFTFTVSDGTN-PFFIIEEGGKEIMTAAPQPFRVDILPVDDGT 2438
+N +SY HDGS + +D F+ TV+DGT+ F+++ + + T PQ RV I +D+
Sbjct: 1602 NKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPD--TALATHKPQVMRVQIRSLDNRL 1659
Query: 2439 PRIVTNLGLQWLEYM-DGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQP 2497
P+I TN G L+ + G LIT K L D D+ L Y++T GP+HGF+
Sbjct: 1660 PQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLG 1719
Query: 2498 GRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFK 2557
++ FTQ D++ I YVL+ E D F F V+D+ N +++ FH+ W+ I +
Sbjct: 1720 NQSTRVFTQADIDEMKISYVLN-EGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLE 1778
Query: 2558 YTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQV 2617
Y V E + + VT+ R G L + + + T+ TA + + Q+
Sbjct: 1779 KEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNK--------QI 1830
Query: 2618 QFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEF 2677
QF+ + T + + I D+ +E E+F + LS P A+L A V I D DE T+
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYI 1890
Query: 2678 DKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSA 2737
+ Y + E G L P+ R GDAS + IC T SA G ++ + SD+ SR
Sbjct: 1891 PEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATG-TISSTVLFSDYISRPEDH 1949
Query: 2738 ASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPND 2796
S + F T TC V++IDDS YEEEE F ++L R T KV +++ D
Sbjct: 1950 TSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYD 2009
Query: 2797 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSR 2856
+ G+ + V+E A V++ V R GTDLS +S+ +R S+ SA G DYV SR
Sbjct: 2010 EPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISR 2069
Query: 2857 KVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQD 2916
++F PGV Q +TILDD P +EG E F + L GA L +P + I I DT D
Sbjct: 2070 NLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
Score = 118 bits (296), Expect = 1e-25
Identities = 113/369 (30%), Positives = 172/369 (46%), Gaps = 33/369 (8%)
Query: 2800 VSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYV-PSSRKV 2858
+ L + V ED+ +++ + R G L + + T+ +A D+ +++++
Sbjct: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDE---TAKKDKDFKWKTNKQI 1830
Query: 2859 EFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVP 2918
+F PG + I+ D +Y E ETF + LS A L P A + I D D
Sbjct: 1831 QFNPGQTTATWRVRIIPDNEY---ETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDES 1886
Query: 2919 SMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQ-------VMEDFEERQ 2971
++ + ++E G L +P+ RSGD S E V C T+ SA + D+ R
Sbjct: 1887 TVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRP 1946
Query: 2972 NADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATIT 3031
+S + F K + K C V I DDS++E EE F V L LP+G GAR + +
Sbjct: 1947 EDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTILA 2005
Query: 3032 ISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRG-DQNRTSKVRCSTRDG---SA 3087
DE P + F +A Y V E A + + V RRG D ++ S + +R SA
Sbjct: 2006 DRYDE--PVLHFGDAEYHVNESA-----RYVEVCVWRRGTDLSQPSSIAVRSRKSEQESA 2058
Query: 3088 QSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDR---EWHESFSLVLGPDDPVEAVLGDV 3144
++G DY SR L F+PGV F+V IL + + E E F L+L P+ AVLG+
Sbjct: 2059 EAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL--QMPMGAVLGEP 2116
Query: 3145 TTATVTILD 3153
T+ I D
Sbjct: 2117 NKTTIFIED 2125
Score = 114 bits (285), Expect = 2e-24
Identities = 181/777 (23%), Positives = 300/777 (38%), Gaps = 150/777 (19%)
Query: 1957 PPR---MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDH-----GHVLWR 2008
PPR M + V ++ +L+ +D+++ +L+F + P H G +
Sbjct: 304 PPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYV 363
Query: 2009 QTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDE-FQFSLT----DGLHVDT 2063
+ +PL + S FT Q++ + Y P + FQ L DG D
Sbjct: 364 VSTDDPLG-----LPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDP 418
Query: 2064 GRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH-LKVTDIDSDDHQVMYIMKEDPG 2122
+ + + P + N+GL L G ++ H + ++D D+ E+
Sbjct: 419 FAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDN---------LEEVK 469
Query: 2123 AGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFKFDVVDGEGN 2181
++ ++HG L + FT AD++ G+ Y H G+ + F+ + +G+
Sbjct: 470 MAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRME----DGH 525
Query: 2182 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITR 2240
+D F ++IL D PP++ TN GL L E V +I+ LSATD DS + + + +
Sbjct: 526 HQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLEN 585
Query: 2241 QPQLGHLEH---AASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVT 2297
QP G+ E +PG S DL + + S+E E + + +G+ E
Sbjct: 586 QPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDED----WHYMEKEGLYEKV 641
Query: 2298 QT-----------------------------------------------FHITLHPVDDS 2310
T F I + PVD
Sbjct: 642 VTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDIL 701
Query: 2311 LPVV---QNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPP---------RHGT 2358
P + L M VQE + L+ +D D++ +++ +T++ P R G
Sbjct: 702 SPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGE 761
Query: 2359 IERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR---FTFTVSDGTNPFFIIEEG 2415
I T + L FT + Q++V+Y + R FT+ V D
Sbjct: 762 IVLTDSPD--TLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAG-------- 811
Query: 2416 GKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDPDTED 2475
+ P F + + PVD+ P VTN G LE G + NL + EL DPDT+
Sbjct: 812 -----NSVPGTFTLFLQPVDNQPPE-VTNRGFAILE---GGSFNL-SSNELHVTDPDTDI 861
Query: 2476 AQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVK 2535
Q+V+ + GP+HG ++ + +F Q DV G + Y H D+F V
Sbjct: 862 DQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVS 920
Query: 2536 DS------------KPNVVSDNVFHIQWSLISFKYTSYNVSE-KAGSVSVTV-----QRT 2577
D PNV + + I S S +V E KA +++ V +
Sbjct: 921 DGVHHIPITIPISVHPNVANRSP-RISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDV 979
Query: 2578 GNLNQYAIVLCRTEQGTASSSSRVSSQPGQQD-------YVEYAGQVQFDEREDTKS 2627
G+L IV + GT + + + Q+D Y AG+V F ++ D S
Sbjct: 980 GDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFS 1036
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/103 (28%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 3062 LNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDY-YPKSRVLKFSPGVDHIFFKVEILSNED 3120
L + + RRG TS + T+D +A+ D+ + ++ ++F+PG ++V I+ + +
Sbjct: 1791 LEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNE 1850
Query: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILP 3163
E E+F ++L +P+ AVL ATV I+D ++ +P
Sbjct: 1851 YETSETFQIILS--EPLMAVLEFPEMATVEIVDPGDESTVYIP 1891
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 525 bits (1352), Expect = e-148
Identities = 452/1608 (28%), Positives = 730/1608 (45%), Gaps = 128/1608 (7%)
Query: 1120 LDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLV-LSRNGKEVQLDKAGRFSWKDVNEKKVR 1178
L S+L+ ++ E L+F++ P G + L + + + F+WKD+++ ++
Sbjct: 315 LTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPIS-----SFTWKDLSDMQIA 369
Query: 1179 FV---HSKEKLRKGYLFLKISDQQFFSEPQL-----INIQAFSTQAPYVLRNEVLHISRG 1230
+ S + R + L++ D FF E I+I+ T AP V N L + G
Sbjct: 370 YQPPNSSHSERRHDEVELEVYD--FFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEG 427
Query: 1231 ERATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHY 1290
+ IT + + D+D+ V + + HG L TL+ + F + +L G++ Y
Sbjct: 428 QSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWL--TLRGGKG--FLFTVADLQAGVVRY 483
Query: 1291 AHDGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNR 1350
HD SDST D V + DGH F + +P++D L+ N ++ + EG + I
Sbjct: 484 HHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGS 543
Query: 1351 ILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQ 1410
+L+A AS + I + IT+ PQ GE+ M P G P F Q
Sbjct: 544 MLRASDVDASDDYIFFNITKP-PQAGEI-----MKKPGP---------GLIGYPVHGFLQ 588
Query: 1411 QDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLEAS 1470
+D+ GI++YRH G DSF+F + + + I I P + PK + S
Sbjct: 589 RDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVS 648
Query: 1471 LHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLP-------LHPNQGIIEHRD---- 1519
H+ +E + I L FI+SE ++VY IT P H + G + D
Sbjct: 649 RHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPK 708
Query: 1520 ---HPHS-PIRYFTQEDINQGKVMYRPP--PAAPHLQELMAFSFAGLPESVKFHFTVSDG 1573
+P + +R FTQ +N KV Y PP PH ++ V+F F+VS+
Sbjct: 709 VVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRD------------VQFTFSVSN- 755
Query: 1574 EH--TSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGLQ-VVVRDAETAPKELF 1630
+H T + I +LP D Q+P + L V+ GG + + + +++ DA+T +
Sbjct: 756 QHGGTLHGICFNITILPVDNQVP--EAFTNPLKVTEGGQSIISTEHILISDADTKLDNID 813
Query: 1631 FELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDG 1690
LR P HG + + P+ +G TF++ D+ ++Y HDG+ +D + + VTDG
Sbjct: 814 LSLRELPLHGRVELNGF----PLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDG 869
Query: 1691 LTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSSPDPEIWIQ 1750
+ VEV D P L A + + +IT ++ D S + ++
Sbjct: 870 TNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMFV 929
Query: 1751 LNYLPSYGTLLRISGSEVEELSE---VSNFTMEDINNKKIRYSAVFETDGHLVTDS---- 1803
+ P +G + R +G V++ S+ +S +I F+T +V+D
Sbjct: 930 IAREPQHGVVRR-AGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGP 988
Query: 1804 -----FYFSVSDMDHNHLDNQIFTIMIT--PAENPPPVIAFADLITVDEGGRAPLSFHHF 1856
Y + H ++ + IT P +N PP IA + VDEG L+ +H
Sbjct: 989 FVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHL 1048
Query: 1857 FATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYF 1916
ATD D D L + P++G +EN F SF +D+ +I Y
Sbjct: 1049 SATDPDTAAD-DLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYV 1107
Query: 1917 QSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSGVVIS 1976
QS H IEPT D F+ YV+DG S +I I NDE P +Q + V +
Sbjct: 1108 QSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQNITVCEGQMKELD 1167
Query: 1977 NSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENGRVL------VQGSTFTYQ 2030
+S +S DLD P + L+F +T+KP HG ++ R + + EN + +F+ +
Sbjct: 1168 SSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSME 1227
Query: 2031 DILAGL-VGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLAINQGLQLS 2089
+ G+ + Y+ + D+F L+DG H + + + P L+ + ++
Sbjct: 1228 LLKTGMRLTYMHDDSESLADDFTIQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMN 1287
Query: 2090 AGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQA 2149
G I+ L D DS ++ Y+ + P G+LQ+ + +S P TQ
Sbjct: 1288 MGETRIISSAILSAIDEDSPREKIYYVFERLPQNGQLQLKIGRDWVPLS---PGMKCTQE 1344
Query: 2150 DISQGQPEYSH-GTGEPGGSFAFKFDVVDGEGNRLIDKSFSISILEDKSPPVITTNKGLV 2208
++ Y+H G + +F F + DG NR I+I + + ++ K LV
Sbjct: 1345 EVDLNLLRYTHTGAMDSQNQDSFTFYLWDGN-NRSPALDCQITIKDMEKGDIVILTKPLV 1403
Query: 2209 LDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSR 2268
+ + +TT L A D P EL+Y IT P+ G +E+ PG+ I++F+Q D+ +
Sbjct: 1404 VSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQ 1463
Query: 2269 NVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVV-QNLGMRVQEGMRK 2327
V YVH S+ SD F F +S+G+ F ITL VD +LPVV +N G+R+ +G
Sbjct: 1464 TVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVG 1523
Query: 2328 TITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYS 2387
++ L+ D DT AE++TF +VQ P+HG + G L FT +D+ V+Y
Sbjct: 1524 LLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGL---LQHNFTQQDVDSKNVAYR 1580
Query: 2388 HDGSNSLKDRFTFTVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIV----- 2442
H G +S D FTF +DGTN FI+ G+ + P F + + +D PRI
Sbjct: 1581 HSGGDSQTDCFTFMATDGTNQGFIV--NGR--VWEEPVLFTIQVDQLDKTAPRITLLHSP 1636
Query: 2443 TNLGLQWLEYMDGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAA 2502
+ +GL +G IT + L DPDTED Q++++I GPKHG +EN
Sbjct: 1637 SQVGL----LKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHE 1692
Query: 2503 TFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYN 2562
F+Q+D+N I Y+++ + D+ +F + D N + + ++WS I + T Y
Sbjct: 1693 KFSQKDLNSKTILYIIN-PSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYE 1751
Query: 2563 VSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQVQFDER 2622
V E G + + + R G A V + Q VS+ G+ V + +QFD
Sbjct: 1752 VCENVGLLPLEIIRRGYSMDSAFVGIKVNQ--------VSAAVGKDFTVIPSKLIQFDPG 1803
Query: 2623 EDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTE 2670
TK I I D + E+ E F V L+ P A+LG T+A V I D++
Sbjct: 1804 MSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSK 1851
Score = 133 bits (334), Expect = 4e-30
Identities = 188/769 (24%), Positives = 314/769 (40%), Gaps = 102/769 (13%)
Query: 1102 PSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQL--VLSRNGKE- 1158
PS+ + ++ G L + L+ D + +DL F +VS P G L +L G E
Sbjct: 1025 PSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEK 1084
Query: 1159 ----VQLDKAGRFSWKDVNEKKVRFVHSKE---KLRKGYLFLKISDQQFFS--EPQLINI 1209
+ +D F WKD+N + +V S+ + + ++D + S P I I
Sbjct: 1085 SNIGISIDS---FQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIII 1141
Query: 1210 QAFSTQAP-YVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVI-EIIDPPLHGQLL-- 1265
+ +AP +V++N + + G+ + + ++ D D PQD ++ I P HG L+
Sbjct: 1142 NPTNDEAPDFVVQN--ITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDR 1199
Query: 1266 ------QTLQSPA------TPIYQFQLDELSRGL-LHYAHDGSDSTSDVAVLQANDGHSF 1312
+ PA P++ F ++ L G+ L Y HD S+S +D +Q +DG
Sbjct: 1200 GFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGK-- 1257
Query: 1313 HNIL--FQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRILQAEAPGASAEEIIYKITQ 1370
H IL V+ +P ND L + + + G I++ IL A S E IY + +
Sbjct: 1258 HKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSA-IDEDSPREKIYYVFE 1316
Query: 1371 DYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGA--PAQ 1428
PQ G++ L + D +P TQ++++ ++ Y H+GA
Sbjct: 1317 RLPQNGQLQLKIGR-------------DWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQN 1363
Query: 1429 SDSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSL 1488
DSF F + +N L+ + + + V L L ++ + G + L
Sbjct: 1364 QDSFTFYLWDGNNRSPALDCQI----TIKDMEKGDIVILTKPLVVSKGDRGF-LTTTTLL 1418
Query: 1489 SFINSEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPH 1548
+ ++KP +++Y IT P P G IE+ +P PI F+Q D+ V Y H
Sbjct: 1419 AVDGTDKPE-ELLYVITSP--PRYGQIEYVHYPGVPITNFSQMDVVGQTVCY------VH 1469
Query: 1549 LQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVF-QVTAPRLAVSP 1607
++ S +F F +S+G T V I L D+ LPV + RLA
Sbjct: 1470 KSKVTV-------SSDRFRFIISNGLRTE-HGVFEITLETVDRALPVVTRNKGLRLAQGA 1521
Query: 1608 GGSTSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKN 1667
G S L + + D +T + L F L + PQHG L + FT +DV+
Sbjct: 1522 VGLLSPDL-LQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQ-----HNFTQQDVDSK 1575
Query: 1668 ALQYIHDGSSTREDSMEISVTDGLTVTMLE----------VRVEVSLSEDRGPRLAAGSS 1717
+ Y H G ++ D TDG + ++V + PR+ S
Sbjct: 1576 NVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHS 1635
Query: 1718 LSITVASKSTA---IITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEV 1774
S K+ IT L D + D +I ++ P +G L + E
Sbjct: 1636 PSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIH---- 1691
Query: 1775 SNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTI 1823
F+ +D+N+K I Y + + +D+ F + D N QI +
Sbjct: 1692 EKFSQKDLNSKTILY--IINPSLEVNSDTVEFQIMDPTGNSATPQILEL 1738
Score = 111 bits (277), Expect = 2e-23
Identities = 97/339 (28%), Positives = 153/339 (45%), Gaps = 34/339 (10%)
Query: 2207 LVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLT 2266
L +D+ + +TT L + ++ L++ IT+ P G++ H ISSFT DL+
Sbjct: 305 LEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLS 364
Query: 2267 SRNVQY--VHSSEAEKHSDAFSFTLSDGVSE--VTQTFHITLHPVDDSLPVVQ-NLGMRV 2321
+ Y +SS +E+ D + D E T HI++ D + P V N G+ +
Sbjct: 365 DMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSL 424
Query: 2322 QEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQ 2381
EG + IT + + VD D + +V V +HG + G+ F FT+ D+
Sbjct: 425 LEGQSRAITWEQFQVVDND-DIGAVRLVTVGGLQHGWL-TLRGGKGF----LFTVADLQA 478
Query: 2382 NRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRI 2441
V Y HD S+S KD F + DG + + F +++LP DD P +
Sbjct: 479 GVVRYHHDDSDSTKDFVVFRIFDGHH--------------SIRHKFPINVLPKDDSPPFL 524
Query: 2442 VTNLGLQWLEYMDGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAA 2501
+TN+ ++ ++ T LI L D D D + + IT P+ G + K PG
Sbjct: 525 ITNVVIE----LEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIG 580
Query: 2502 AT---FTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDS 2537
F Q D+ G+I Y +I E DSFQF++ DS
Sbjct: 581 YPVHGFLQRDLFNGIIYYRHFGGEIFE--DSFQFVLWDS 617
Score = 49.3 bits (116), Expect = 8e-05
Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 3041 IEFEEAAYQVREPAGPDAIAILNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYP-KSRV 3099
IE+ + Y+V E G +L +++IRRG ++ V SA G D+ S++
Sbjct: 1743 IEWSQTEYEVCENVG-----LLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKL 1797
Query: 3100 LKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDPVEAVLGDVTTATVTILDQE 3155
++F PG+ + + I + E E F ++L + PV AVLG T A V ILD +
Sbjct: 1798 IQFDPGMSTKMWNIAITYDGLEEDDEVFEVIL--NSPVNAVLGTKTKAAVKILDSK 1851
>gi|239755070 PREDICTED: similar to proprotein convertase
subtilisin/kexin type 5 [Homo sapiens]
Length = 853
Score = 315 bits (806), Expect = 8e-85
Identities = 206/668 (30%), Positives = 283/668 (42%), Gaps = 63/668 (9%)
Query: 450 CVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH- 508
C +C Y C AC CS+C C C+ + G CV CG GFY D+
Sbjct: 60 CYKTCPEKTYSEAVECKACDSNCSSCDQN-GCYWCEEGFFLLGGSCVRKCGPGFYGDQEM 118
Query: 509 -SCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSC-----GKGFYNRQGTCSACD 562
C CH +C C GP C +C++ L +LR G C + GK + + C
Sbjct: 119 GECESCHRACETCTGPGHDECSSCQEGLQLLR-GMCVHATKTQEEGKFWNDILRKLQPCH 177
Query: 563 QSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADA-TGRCKVCHNSCASCSGPTPS 621
SC +C S+ C +C + L C+S CP G + +G C+ C +CA CSG
Sbjct: 178 SSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG--AD 235
Query: 622 HCTAC----SPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPE 677
C C P L +G C +C EG Y++ G+C+ C S C C G A ++C C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNA-TNCHSC---- 290
Query: 678 EGLQVEQLSDVGIPSGECLAQC-RAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSH 736
EG V + G C C H +E G+C+ C + C C + C +C P
Sbjct: 291 EGGHV-------LHHGVCQENCPERHVAVE--GVCKHCPEMCQDCIHEK--TCKECMPEF 339
Query: 737 VLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHI-SLTNGNCRTSCR 795
L D C CP G++ C CH C +C GP DC C L +G C C
Sbjct: 340 FLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECP 399
Query: 796 EEQFL-NLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD---CPSGYY 851
+ C DCH C C ++ C CQ + C+ + PS Y+
Sbjct: 400 AGTYYEKQTKECRDCHKSCLTC-----SSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYW 454
Query: 852 AERG-ACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLD-DNHVCQPC 909
E CK CH C C G C +C N +L +T TC C G+Y D D++ C C
Sbjct: 455 DEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNT-TCVKDCPEGYYADEDSNRCAHC 513
Query: 910 NTHCGSCDSQAS--CTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSG 967
++ C +C+ + S C SCR P L EC + C YY D ST C+ C+ SC C G
Sbjct: 514 HSSCRTCEGRHSRQCHSCR-PGWFQLGKECLLQ-CREGYYADNSTGRCERCNRSCKGCQG 571
Query: 968 PLKTDCLQCMDGYVL--QDGACVEQCLSSFY--QDSGLC-KCDSYCLQCQGPH--ECTRC 1020
P TDCL C + L G C C +Y Q + C +C C QC+G C C
Sbjct: 572 PRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSC 631
Query: 1021 KGPFLLLEAQCVQEC--GKGYFADHAKHKCTACPQGCLQCS--HRDRCHLCDHGFFL--K 1074
+ L+ C +C G+ + K C C + C++C C LC L
Sbjct: 632 VWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMD 691
Query: 1075 SGLCVYNC 1082
C++ C
Sbjct: 692 ESHCLHCC 699
Score = 311 bits (797), Expect = 8e-84
Identities = 216/656 (32%), Positives = 291/656 (44%), Gaps = 75/656 (11%)
Query: 421 CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFY--QAGSLCLACQPQCSTCTSG 478
C +C +C Q+ C C++ LL G CV CG GFY Q C +C C TCT
Sbjct: 78 CDSNCSSCDQNG--CYWCEEGFFLL-GGSCVRKCGPGFYGDQEMGECESCHRACETCTGP 134
Query: 479 L--ECSSCQPPLLMRHGQCV---PTCGDG-FYQD-RHSCAVCHESCAGCWGPTEKHCLAC 531
ECSSCQ L + G CV T +G F+ D CH SC C G C +C
Sbjct: 135 GHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATL-CTSC 193
Query: 532 RDPLHVLRDGGCESSCGKGFYN--RQGTCSACDQSCDSCGPSSPRCLTCTEKT----VLH 585
++L C SSC +G + R G+C C ++C C + C C + LH
Sbjct: 194 PKGAYLLAQA-CVSSCPQGTWPSVRSGSCENCTEACAICS-GADLCKKCQMQPGHPLFLH 251
Query: 586 DGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGF 645
+G+C S+CP G YA+ G C+ C + C +C G ++C +C L G C C E
Sbjct: 252 EGRCYSKCPEGSYAE-DGICERCSSPCRTCEG-NATNCHSCEGGHVLHHGVCQENCPERH 309
Query: 646 YSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYL 705
+ GVCK C C C+ H CK E + + + C C FY
Sbjct: 310 VAVEGVCKHCPEMCQDCI-----HEKTCK--------ECMPEFFLHDDMCHQSCPRGFYA 356
Query: 706 ESTGICEACHQSCFRCAGKSPHNCTDC-GPSHVLLDGQCLSQCPDGYFHQEGS--CTECH 762
+S C CH+ C C+G +C C S VL DG CL +CP G ++++ + C +CH
Sbjct: 357 DSHH-CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKQTKECRDCH 415
Query: 763 PTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGY-------CADCHHLCQH 815
+C C C +C + + N R SC + + Y C CH C H
Sbjct: 416 KSCLTCSS--SGTCTTCQKGLIM---NPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFH 470
Query: 816 CAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGA--CKKCHSSCRTCQGRGPF 873
C + C + LLL CV DCP GYYA+ + C CHSSCRTC+GR
Sbjct: 471 CMGPAEDQCQTC----PMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSR 526
Query: 874 SCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSCDSQ--ASCTSCRDPNK 930
C SC C C G+Y D++ C+ CN C C C SC D
Sbjct: 527 QCHSCRPGW-FQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSC-DRFF 584
Query: 931 VLLF--GECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACV 988
LL GEC + SC YY++ ST TC+ C +C C G +CL C+ Y L G C
Sbjct: 585 FLLRSKGEC-HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICT 643
Query: 989 EQCLSSFYQ----DSGLC-KCDSYCLQCQGP--HECTRCKGPFLLL--EAQCVQEC 1035
CL Y+ + C KC C++C+GP CT C +L E+ C+ C
Sbjct: 644 SDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDESHCLHCC 699
Score = 307 bits (787), Expect = 1e-82
Identities = 182/616 (29%), Positives = 272/616 (44%), Gaps = 51/616 (8%)
Query: 495 CVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNR 554
C TC + Y + C C +C+ C + C C + +L G C CG GFY
Sbjct: 60 CYKTCPEKTYSEAVECKACDSNCSSC---DQNGCYWCEEGFFLL-GGSCVRKCGPGFYGD 115
Query: 555 Q--GTCSACDQSCDSC-GPSSPRCLTCTEKTVLHDGKCM----SECPGGYYADATGRCKV 607
Q G C +C ++C++C GP C +C E L G C+ ++ G ++ D + +
Sbjct: 116 QEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 608 CHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD--HGVCKACHSSCLACMGP 665
CH+SC +C+G + + CT+C L C+ C +G + G C+ C +C C G
Sbjct: 176 CHSSCKTCNG-SATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG- 233
Query: 666 APSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKS 725
CKK Q++ + + G C ++C Y E GICE C C C G +
Sbjct: 234 ----ADLCKK----CQMQPGHPLFLHEGRCYSKCPEGSYAED-GICERCSSPCRTCEGNA 284
Query: 726 PHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISL 785
NC C HVL G C CP+ + EG C C C+ C E C C P L
Sbjct: 285 T-NCHSCEGGHVLHHGVCQENCPERHVAVEGVCKHCPEMCQDCIH--EKTCKECMPEFFL 341
Query: 786 TNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD 845
+ C SC + + +C CH C C+ + +CL + ++L C+ +
Sbjct: 342 HDDMCHQSCPRGFYADS-HHCVPCHKDCLECSGPKADDCELCLE---SSWVLYDGLCLEE 397
Query: 846 CPSGYYAERGA--CKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTT--CFPGHYLD 901
CP+G Y E+ C+ CH SC TC G +C++C L+++ G+C C P Y D
Sbjct: 398 CPAGTYYEKQTKECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWD 455
Query: 902 DNHV-CQPCNTHCGSC--DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC 958
++ C+PC+ C C ++ C +C P LL + C YY D +N C C
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTC--PMNSLLLNTTCVKDCPEGYYADEDSNRCAHC 513
Query: 959 DWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQD--SGLC-KCDSYCLQCQGPH 1015
SC C G C C G+ C+ QC +Y D +G C +C+ C CQGP
Sbjct: 514 HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPR 573
Query: 1016 --ECTRCKGPFLLL--EAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRD--RCHLCDH 1069
+C C F LL + +C + C Y+ + + C C C QC + C C
Sbjct: 574 PTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVW 633
Query: 1070 GFFLKSGLCVYNCVPG 1085
+ L G+C +C+ G
Sbjct: 634 SYHLMGGICTSDCLVG 649
Score = 298 bits (762), Expect = 1e-79
Identities = 176/576 (30%), Positives = 260/576 (45%), Gaps = 42/576 (7%)
Query: 540 DGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYA 599
D C +C + Y+ C ACD +C SC + C C E L G C+ +C G+Y
Sbjct: 57 DHHCYKTCPEKTYSEAVECKACDSNCSSCDQNG--CYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 600 D-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRC---GEG-FYSD-HGVCK 653
D G C+ CH +C +C+GP C++C L +G C+ EG F++D +
Sbjct: 115 DQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQ 174
Query: 654 ACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQC-RAHFYLESTGICE 712
CHSSC C G A + CT C K + + C++ C + + +G CE
Sbjct: 175 PCHSSCKTCNGSA-TLCTSCPK-----------GAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 713 ACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTECHPTCRQCHG 770
C ++C C+G P H L +G+C S+CP+G + ++G C C CR C G
Sbjct: 223 NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEG 282
Query: 771 PLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRC 830
++C SC L +G C+ +C E+ + + G C C +CQ C + C C
Sbjct: 283 N-ATNCHSCEGGHVLHHGVCQENC-PERHVAVEGVCKHCPEMCQDCIHE-----KTCKEC 335
Query: 831 QNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC 890
+ L D C CP G+YA+ C CH C C G C C + + + G C
Sbjct: 336 M-PEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLC 394
Query: 891 STTCFPGHYLD-DNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQ-YESCAPQYYL 948
C G Y + C+ C+ C +C S +CT+C+ + G C E C+P Y
Sbjct: 395 LEECPAGTYYEKQTKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYW 454
Query: 949 DFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFY--QDSGLC-KCD 1005
D CK C C C GP + C C +L + CV+ C +Y +DS C C
Sbjct: 455 DEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCH 514
Query: 1006 SYCLQCQGPH--ECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCS--HR 1061
S C C+G H +C C+ + L +C+ +C +GY+AD++ +C C + C C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 1062 DRCHLCDHGFFL--KSGLCVYNCVPGFSVHTSNETC 1095
C CD FFL G C +C + V S +TC
Sbjct: 575 TDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTC 610
Score = 263 bits (671), Expect = 3e-69
Identities = 180/649 (27%), Positives = 247/649 (38%), Gaps = 76/649 (11%)
Query: 260 RCGKGQSRARRHGQC------CEECVSPA---------------GSCSYDGVVRYQDEMW 298
+CG G + G+C CE C P G C + + + + W
Sbjct: 107 KCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW 166
Query: 299 KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFM 358
+ C TC C + L+ C+S +
Sbjct: 167 NDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL------AQACVSSCPQGTWPSVRSGS 220
Query: 359 SSNASEVKRIPEGEKWEDGPCKVCECR-GAQVTCYEPSC-PPCPVGTLALEVKGQCCPDC 416
N +E I G CK C+ + G + +E C CP G+ A + C C
Sbjct: 221 CENCTEACAICSGADL----CKKCQMQPGHPLFLHEGRCYSKCPEGSYA---EDGICERC 273
Query: 417 TSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCT 476
+S C TC + +C C+ +L +G C +C +C C C C
Sbjct: 274 SS-----PCRTCEGNATNCHSCEGG-HVLHHGVCQENCPERHVAVEGVCKHCPEMCQDCI 327
Query: 477 SGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLH 536
C C P + C +C GFY D H C CH+ C C GP C C +
Sbjct: 328 HEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 537 VLRDGGCESSCGKGFYNRQGT--CSACDQSCDSCGPSSPRCLTCTEKTVLHD-GKCMSE- 592
VL DG C C G Y + T C C +SC +C SS C TC + +++ G CM+
Sbjct: 388 VLYDGLCLEECPAGTYYEKQTKECRDCHKSCLTCS-SSGTCTTCQKGLIMNPRGSCMANE 446
Query: 593 --CPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDH- 649
P Y+ + CK CH C C GP C C L C+ C EG+Y+D
Sbjct: 447 KCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADED 506
Query: 650 -GVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLE-S 707
C CHSSC C G C C+ L ECL QCR +Y + S
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQL-----------GKECLLQCREGYYADNS 555
Query: 708 TGICEACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEG--SCTECHP 763
TG CE C++SC C G P +C C LL G+C CPD Y+ ++ +C CHP
Sbjct: 556 TGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHP 615
Query: 764 TCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVG---YCADCHHLCQHCAADL 820
TC QC G +C+SC L G C + C ++ G C CH C C
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPG 675
Query: 821 HNTGSICLRCQNAHYLLLGD--HCVPDCPSGYYAERGACKKCHSSCRTC 867
++C A+ +L D HC+ C + C C + C
Sbjct: 676 AKNCTLC----PANLVLHMDESHCLHCCNTSDPPSAQECCDCQDTTDEC 720
Score = 174 bits (442), Expect = 1e-42
Identities = 165/627 (26%), Positives = 231/627 (36%), Gaps = 94/627 (14%)
Query: 84 CPECVLRTPGSCHHEKKIHEHGTEWAS-----SPC--SVCSCNHGEVRCTPQPCPPLSCG 136
C E + G C H K E G W PC S +CN CT P
Sbjct: 142 CQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLA 201
Query: 137 HQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQP 196
++ P+G+ V G + C+ E G D C KC + G P
Sbjct: 202 QACVSSCPQGTWPSVRSGSCENCT-EACAICSGAD----LCKKCQMQPG---------HP 247
Query: 197 LFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQAC 256
LF ++ G+C +C S + G + + C T C+ CH
Sbjct: 248 LFLHE--------GRCYSKCPEGSYAEDGIC-----ERCSSPCRT--CEGNATNCHS--- 289
Query: 257 LPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG----SACEFCMCD--- 309
C G HG C E C P + +GV ++ EM + C+ CM +
Sbjct: 290 ----CEGG--HVLHHGVCQENC--PERHVAVEGVCKHCPEMCQDCIHEKTCKECMPEFFL 341
Query: 310 HGQVTCQTGECAKVECARDEELIHLDGKCCPECIS-RNGYCVYEETGEFMSSNASEVKRI 368
H + Q+ C + A + K C EC + C ++ + ++
Sbjct: 342 HDDMCHQS--CPRGFYADSHHCVPCH-KDCLECSGPKADDCELCLESSWVLYDGLCLEEC 398
Query: 369 PEGEKWEDGPCKVCECRGAQVTCYEP-SCPPCPVGTLALEVKGQC--------------- 412
P G +E + +C + +TC +C C G L + +G C
Sbjct: 399 PAGTYYEKQTKECRDCHKSCLTCSSSGTCTTCQKG-LIMNPRGSCMANEKCSPSEYWDED 457
Query: 413 CPDCTSVHCHPDCLTC-SQSPDHCDLCQDPTKLLQNGWCVHSCGLGFY--QAGSLCLACQ 469
P C CH C C + D C C LL N CV C G+Y + + C C
Sbjct: 458 APGCKP--CHVKCFHCMGPAEDQCQTC-PMNSLLLNTTCVKDCPEGYYADEDSNRCAHCH 514
Query: 470 PQCSTCTS--GLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCAGCWGPTE 525
C TC +C SC+P +C+ C +G+Y D + C C+ SC GC GP
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 526 KHCLACRDPLHVLRD-GGCESSCGKGFYNRQG--TCSACDQSCDSC-GPSSPRCLTCTEK 581
CL+C +LR G C SC +Y Q TC C +CD C G + CL+C
Sbjct: 575 TDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWS 634
Query: 582 TVLHDGKCMSECPGGYYADATG---RCKVCHNSCASCSGPTPSHCTACSPPKALR--QGH 636
L G C S+C G Y G C+ CH SC C GP +CT C L + H
Sbjct: 635 YHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDESH 694
Query: 637 CLPRCGEGFYSDHGVCKACHSSCLACM 663
CL C C C + C+
Sbjct: 695 CLHCCNTSDPPSAQECCDCQDTTDECI 721
Score = 118 bits (296), Expect = 1e-25
Identities = 83/319 (26%), Positives = 119/319 (37%), Gaps = 70/319 (21%)
Query: 826 ICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLS 885
I L+C N HC CP Y+E CK C S+C +C G C C+ L
Sbjct: 48 IHLKCGNR----FDHHCYKTCPEKTYSEAVECKACDSNCSSCDQNG---CYWCEEGFFLL 100
Query: 886 HTGTCSTTCFPGHYLDD--------NHVCQ------------------------------ 907
G+C C PG Y D + C+
Sbjct: 101 -GGSCVRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKT 159
Query: 908 ---------------PCNTHCGSCDSQAS-CTSCRDPNKVLLFGECQYESCAPQYYLDFS 951
PC++ C +C+ A+ CTSC P L + SC +
Sbjct: 160 QEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSC--PKGAYLLAQACVSSCPQGTWPSVR 217
Query: 952 TNTCKECDWSCSACSGPLKTDCLQCMDGY--VLQDGACVEQCLSSFYQDSGLC-KCDSYC 1008
+ +C+ C +C+ CSG Q G+ L +G C +C Y + G+C +C S C
Sbjct: 218 SGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPC 277
Query: 1009 LQCQG-PHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLC 1067
C+G C C+G +L C + C + + A + C CP+ C C H C C
Sbjct: 278 RTCEGNATNCHSCEGGHVLHHGVCQENCPERHVA--VEGVCKHCPEMCQDCIHEKTCKEC 335
Query: 1068 DHGFFLKSGLCVYNCVPGF 1086
FFL +C +C GF
Sbjct: 336 MPEFFLHDDMCHQSCPRGF 354
>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
sapiens]
Length = 853
Score = 313 bits (802), Expect = 2e-84
Identities = 203/667 (30%), Positives = 281/667 (42%), Gaps = 61/667 (9%)
Query: 450 CVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH- 508
C +C Y C AC C +C C C+ + G CV CG GFY D+
Sbjct: 60 CYKTCPEKTYSEAVECKACDSNCGSCDQN-GCYWCEEGFFLLGGSCVRKCGPGFYGDQEM 118
Query: 509 -SCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSC-----GKGFYNRQGTCSACD 562
C CH +C C GP C +C++ L +LR G C + GK + + C
Sbjct: 119 GECESCHRACETCTGPGHDECSSCQEGLQLLR-GMCVHATKTQEEGKFWNDILRKLQPCH 177
Query: 563 QSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADA-TGRCKVCHNSCASCSGPTPS 621
SC +C S+ C +C + L C+S CP G + +G C+ C +CA CSG
Sbjct: 178 SSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGA--D 235
Query: 622 HCTACSP----PKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPE 677
C C P L +G C +C EG Y++ G+C+ C S C C G A ++C C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNA-TNCHSC---- 290
Query: 678 EGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHV 737
EG V + G C C ++ G+C+ C + C C + C +C P
Sbjct: 291 EGGHV-------LHHGVCQENCPER-HVAVKGVCKHCPEMCQDCIHEK--TCKECTPEFF 340
Query: 738 LLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHI-SLTNGNCRTSCRE 796
L D C CP G++ C CH C +C GP DC C L +G C C
Sbjct: 341 LHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPA 400
Query: 797 EQFLNL-VGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD---CPSGYYA 852
+ C DCH C C++ C CQ + C+ + PS Y+
Sbjct: 401 GTYYEKETKECRDCHKSCLTCSSS-----GTCTTCQKGLIMNPRGSCMANEKCSPSEYWD 455
Query: 853 ERG-ACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLD-DNHVCQPCN 910
E CK CH C C G C +C N +L +T TC C G+Y D D++ C C+
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNT-TCVKDCPEGYYADEDSNRCAHCH 514
Query: 911 THCGSCDSQAS--CTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGP 968
+ C +C+ + S C SCR P L EC + C YY D ST C+ C+ SC C GP
Sbjct: 515 SSCRTCEGRHSRQCHSCR-PGWFQLGKECLLQ-CREGYYADNSTGRCERCNRSCKGCQGP 572
Query: 969 LKTDCLQCMDGYVL--QDGACVEQCLSSFY--QDSGLC-KCDSYCLQCQGPH--ECTRCK 1021
TDCL C + L G C C +Y Q + C +C C QC+G C C
Sbjct: 573 RPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCV 632
Query: 1022 GPFLLLEAQCVQECGKGYF--ADHAKHKCTACPQGCLQCS--HRDRCHLCDHGFFL--KS 1075
+ L+ C +C G + + K C C + C++C C LC L
Sbjct: 633 WSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDD 692
Query: 1076 GLCVYNC 1082
C++ C
Sbjct: 693 SHCLHCC 699
Score = 308 bits (789), Expect = 7e-83
Identities = 217/658 (32%), Positives = 292/658 (44%), Gaps = 79/658 (12%)
Query: 421 CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFY--QAGSLCLACQPQCSTCTSG 478
C +C +C Q+ C C++ LL G CV CG GFY Q C +C C TCT
Sbjct: 78 CDSNCGSCDQNG--CYWCEEGFFLL-GGSCVRKCGPGFYGDQEMGECESCHRACETCTGP 134
Query: 479 L--ECSSCQPPLLMRHGQCV---PTCGDG-FYQD-RHSCAVCHESCAGCWGPTEKHCLAC 531
ECSSCQ L + G CV T +G F+ D CH SC C G C +C
Sbjct: 135 GHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATL-CTSC 193
Query: 532 RDPLHVLRDGGCESSCGKGFYN--RQGTCSACDQSCDSCGPSSPRCLTCTEKT----VLH 585
++L C SSC +G + R G+C C ++C C + C C + LH
Sbjct: 194 PKGAYLLAQA-CVSSCPQGTWPSVRSGSCENCTEACAICS-GADLCKKCQMQPGHPLFLH 251
Query: 586 DGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGF 645
+G+C S+CP G YA+ G C+ C + C +C G ++C +C L G C C E
Sbjct: 252 EGRCYSKCPEGSYAE-DGICERCSSPCRTCEG-NATNCHSCEGGHVLHHGVCQENCPERH 309
Query: 646 YSDHGVCKACHSSCLACMGPAPSHCTGCKK--PEEGLQVEQLSDVGIPSGECLAQCRAHF 703
+ GVCK C C C+ H CK+ PE L + C C F
Sbjct: 310 VAVKGVCKHCPEMCQDCI-----HEKTCKECTPEFFLHDDM----------CHQSCPRGF 354
Query: 704 YLESTGICEACHQSCFRCAGKSPHNCTDC-GPSHVLLDGQCLSQCPDGYFHQEGS--CTE 760
Y +S C CH+ C C+G +C C S VL DG CL +CP G ++++ + C +
Sbjct: 355 YADSRH-CVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKECRD 413
Query: 761 CHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGY-------CADCHHLC 813
CH +C C C +C + + N R SC + + Y C CH C
Sbjct: 414 CHKSCLTCSS--SGTCTTCQKGLIM---NPRGSCMANEKCSPSEYWDEDAPGCKPCHVKC 468
Query: 814 QHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGA--CKKCHSSCRTCQGRG 871
HC + C + LLL CV DCP GYYA+ + C CHSSCRTC+GR
Sbjct: 469 FHCMGPAEDQCQTC----PMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRH 524
Query: 872 PFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSCDSQ--ASCTSCRDP 928
C SC C C G+Y D++ C+ CN C C C SC D
Sbjct: 525 SRQCHSCRPGW-FQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRPTDCLSC-DR 582
Query: 929 NKVLLF--GECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGA 986
LL GEC + SC YY++ ST TC+ C +C C G +CL C+ Y L G
Sbjct: 583 FFFLLRSKGEC-HRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGI 641
Query: 987 CVEQCLSSFYQ----DSGLC-KCDSYCLQCQGP--HECTRCKGPFLLL--EAQCVQEC 1035
C CL Y+ + C KC C++C+GP CT C +L ++ C+ C
Sbjct: 642 CTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCC 699
Score = 305 bits (781), Expect = 6e-82
Identities = 181/616 (29%), Positives = 271/616 (43%), Gaps = 51/616 (8%)
Query: 495 CVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNR 554
C TC + Y + C C +C C + C C + +L G C CG GFY
Sbjct: 60 CYKTCPEKTYSEAVECKACDSNCGSC---DQNGCYWCEEGFFLL-GGSCVRKCGPGFYGD 115
Query: 555 Q--GTCSACDQSCDSC-GPSSPRCLTCTEKTVLHDGKCM----SECPGGYYADATGRCKV 607
Q G C +C ++C++C GP C +C E L G C+ ++ G ++ D + +
Sbjct: 116 QEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 608 CHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD--HGVCKACHSSCLACMGP 665
CH+SC +C+G + + CT+C L C+ C +G + G C+ C +C C G
Sbjct: 176 CHSSCKTCNG-SATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG- 233
Query: 666 APSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKS 725
CKK Q++ + + G C ++C Y E GICE C C C G +
Sbjct: 234 ----ADLCKK----CQMQPGHPLFLHEGRCYSKCPEGSYAED-GICERCSSPCRTCEGNA 284
Query: 726 PHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISL 785
NC C HVL G C CP+ + +G C C C+ C E C C P L
Sbjct: 285 T-NCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIH--EKTCKECTPEFFL 341
Query: 786 TNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD 845
+ C SC + + +C CH C C+ + +CL + ++L C+ +
Sbjct: 342 HDDMCHQSCPRGFYADS-RHCVPCHKDCLECSGPKADDCELCLE---SSWVLYDGLCLEE 397
Query: 846 CPSGYYAERGA--CKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTT--CFPGHYLD 901
CP+G Y E+ C+ CH SC TC G +C++C L+++ G+C C P Y D
Sbjct: 398 CPAGTYYEKETKECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWD 455
Query: 902 DNHV-CQPCNTHCGSC--DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC 958
++ C+PC+ C C ++ C +C P LL + C YY D +N C C
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTC--PMNSLLLNTTCVKDCPEGYYADEDSNRCAHC 513
Query: 959 DWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQD--SGLC-KCDSYCLQCQGPH 1015
SC C G C C G+ C+ QC +Y D +G C +C+ C CQGP
Sbjct: 514 HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPR 573
Query: 1016 --ECTRCKGPFLLL--EAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRD--RCHLCDH 1069
+C C F LL + +C + C Y+ + + C C C QC + C C
Sbjct: 574 PTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVW 633
Query: 1070 GFFLKSGLCVYNCVPG 1085
+ L G+C +C+ G
Sbjct: 634 SYHLMGGICTSDCLVG 649
Score = 298 bits (763), Expect = 7e-80
Identities = 176/576 (30%), Positives = 261/576 (45%), Gaps = 42/576 (7%)
Query: 540 DGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYA 599
D C +C + Y+ C ACD +C SC + C C E L G C+ +C G+Y
Sbjct: 57 DHHCYKTCPEKTYSEAVECKACDSNCGSCDQNG--CYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 600 D-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRC---GEG-FYSD-HGVCK 653
D G C+ CH +C +C+GP C++C L +G C+ EG F++D +
Sbjct: 115 DQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQ 174
Query: 654 ACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQC-RAHFYLESTGICE 712
CHSSC C G A + CT C K + + C++ C + + +G CE
Sbjct: 175 PCHSSCKTCNGSA-TLCTSCPK-----------GAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 713 ACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTECHPTCRQCHG 770
C ++C C+G P H L +G+C S+CP+G + ++G C C CR C G
Sbjct: 223 NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEG 282
Query: 771 PLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRC 830
++C SC L +G C+ +C E+ + + G C C +CQ C + C C
Sbjct: 283 N-ATNCHSCEGGHVLHHGVCQENC-PERHVAVKGVCKHCPEMCQDCIHE-----KTCKEC 335
Query: 831 QNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC 890
+ L D C CP G+YA+ C CH C C G C C + + + G C
Sbjct: 336 -TPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLC 394
Query: 891 STTCFPGHYLD-DNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQ-YESCAPQYYL 948
C G Y + + C+ C+ C +C S +CT+C+ + G C E C+P Y
Sbjct: 395 LEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYW 454
Query: 949 DFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFY--QDSGLC-KCD 1005
D CK C C C GP + C C +L + CV+ C +Y +DS C C
Sbjct: 455 DEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCH 514
Query: 1006 SYCLQCQGPH--ECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCS--HR 1061
S C C+G H +C C+ + L +C+ +C +GY+AD++ +C C + C C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 1062 DRCHLCDHGFFL--KSGLCVYNCVPGFSVHTSNETC 1095
C CD FFL G C +C + V S +TC
Sbjct: 575 TDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTC 610
Score = 259 bits (663), Expect = 3e-68
Identities = 179/648 (27%), Positives = 243/648 (37%), Gaps = 74/648 (11%)
Query: 260 RCGKGQSRARRHGQC------CEECVSPA---------------GSCSYDGVVRYQDEMW 298
+CG G + G+C CE C P G C + + + + W
Sbjct: 107 KCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW 166
Query: 299 KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFM 358
+ C TC C + L+ C+S +
Sbjct: 167 NDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL------AQACVSSCPQGTWPSVRSGS 220
Query: 359 SSNASEVKRIPEGEKWEDGPCKVCECR-GAQVTCYEPSC-PPCPVGTLALEVKGQCCPDC 416
N +E I G CK C+ + G + +E C CP G+ A + C C
Sbjct: 221 CENCTEACAICSGADL----CKKCQMQPGHPLFLHEGRCYSKCPEGSYA---EDGICERC 273
Query: 417 TSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCT 476
+S C TC + +C C+ +L +G C +C +C C C C
Sbjct: 274 SS-----PCRTCEGNATNCHSCEGG-HVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCI 327
Query: 477 SGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLH 536
C C P + C +C GFY D C CH+ C C GP C C +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 537 VLRDGGCESSCGKGFYNRQGT--CSACDQSCDSCGPSSPRCLTCTEKTVLHD-GKCMSE- 592
VL DG C C G Y + T C C +SC +C SS C TC + +++ G CM+
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCS-SSGTCTTCQKGLIMNPRGSCMANE 446
Query: 593 --CPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDH- 649
P Y+ + CK CH C C GP C C L C+ C EG+Y+D
Sbjct: 447 KCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADED 506
Query: 650 -GVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLE-S 707
C CHSSC C G C C+ L ECL QCR +Y + S
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQL-----------GKECLLQCREGYYADNS 555
Query: 708 TGICEACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEG--SCTECHP 763
TG CE C++SC C G P +C C LL G+C CPD Y+ ++ +C CHP
Sbjct: 556 TGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHP 615
Query: 764 TCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVG---YCADCHHLCQHCAADL 820
TC QC G +C+SC L G C + C ++ G C CH C C
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGP- 674
Query: 821 HNTGSICLRCQNAHYLLLGD-HCVPDCPSGYYAERGACKKCHSSCRTC 867
C C L + D HC+ C + C C + C
Sbjct: 675 --GAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDEC 720
Score = 172 bits (435), Expect = 8e-42
Identities = 165/634 (26%), Positives = 231/634 (36%), Gaps = 108/634 (17%)
Query: 84 CPECVLRTPGSCHHEKKIHEHGTEWAS-----SPC--SVCSCNHGEVRCTPQPCPPLSCG 136
C E + G C H K E G W PC S +CN CT P
Sbjct: 142 CQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLA 201
Query: 137 HQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQP 196
++ P+G+ V G + C+ E G D C KC + G P
Sbjct: 202 QACVSSCPQGTWPSVRSGSCENCT-EACAICSGAD----LCKKCQMQPG---------HP 247
Query: 197 LFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQAC 256
LF ++ G+C +C S + G + + C T C+ CH
Sbjct: 248 LFLHE--------GRCYSKCPEGSYAEDGIC-----ERCSSPCRT--CEGNATNCHS--- 289
Query: 257 LPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQ 316
C G HG C E C P + GV ++ EM C+ C+ + TC+
Sbjct: 290 ----CEGG--HVLHHGVCQENC--PERHVAVKGVCKHCPEM-----CQDCI---HEKTCK 333
Query: 317 TGECAKVECARDEEL-------IHLDGK----CCPECISRNG----YCVYEETGEFMSSN 361
EC D+ + D + C +C+ +G C ++ +
Sbjct: 334 --ECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYD 391
Query: 362 ASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEP-SCPPCPVGTLALEVKGQC-------- 412
++ P G +E + +C + +TC +C C G L + +G C
Sbjct: 392 GLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKG-LIMNPRGSCMANEKCSP 450
Query: 413 -------CPDCTSVHCHPDCLTC-SQSPDHCDLCQDPTKLLQNGWCVHSCGLGFY--QAG 462
P C CH C C + D C C LL N CV C G+Y +
Sbjct: 451 SEYWDEDAPGCKP--CHVKCFHCMGPAEDQCQTC-PMNSLLLNTTCVKDCPEGYYADEDS 507
Query: 463 SLCLACQPQCSTCTS--GLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
+ C C C TC +C SC+P +C+ C +G+Y D + C C+ SC
Sbjct: 508 NRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 519 GCWGPTEKHCLACRDPLHVLRD-GGCESSCGKGFYNRQG--TCSACDQSCDSC-GPSSPR 574
GC GP CL+C +LR G C SC +Y Q TC C +CD C G +
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627
Query: 575 CLTCTEKTVLHDGKCMSECPGGYYADATG---RCKVCHNSCASCSGPTPSHCTACSPPKA 631
CL+C L G C S+C G Y G C+ CH SC C GP +CT C
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLV 687
Query: 632 LR--QGHCLPRCGEGFYSDHGVCKACHSSCLACM 663
L HCL C C C + C+
Sbjct: 688 LHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECI 721
>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
sapiens]
Length = 853
Score = 312 bits (800), Expect = 4e-84
Identities = 203/667 (30%), Positives = 281/667 (42%), Gaps = 61/667 (9%)
Query: 450 CVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRH- 508
C +C Y C AC C +C C C+ + G CV CG GFY D+
Sbjct: 60 CYKTCPEKTYSEEVECKACDSNCGSCDQN-GCYWCEEGFFLLGGSCVRKCGPGFYGDQEM 118
Query: 509 -SCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSC-----GKGFYNRQGTCSACD 562
C CH +C C GP C +C++ L +LR G C + GK + + C
Sbjct: 119 GECESCHRACETCTGPGHDECSSCQEGLQLLR-GMCVHATKTQEEGKFWNDILRKLQPCH 177
Query: 563 QSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADA-TGRCKVCHNSCASCSGPTPS 621
SC +C S+ C +C + L C+S CP G + +G C+ C +CA CSG
Sbjct: 178 SSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSGA--D 235
Query: 622 HCTACSP----PKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPE 677
C C P L +G C +C EG Y++ G+C+ C S C C G A ++C C
Sbjct: 236 LCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNA-TNCHSC---- 290
Query: 678 EGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHV 737
EG V + G C C ++ G+C+ C + C C + C +C P
Sbjct: 291 EGGHV-------LHHGVCQENCPER-HVAVKGVCKHCPEMCQDCIHEK--TCKECTPEFF 340
Query: 738 LLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHI-SLTNGNCRTSCRE 796
L D C CP G++ C CH C +C GP DC C L +G C C
Sbjct: 341 LHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLCLEECPA 400
Query: 797 EQFLNL-VGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD---CPSGYYA 852
+ C DCH C C++ C CQ + C+ + PS Y+
Sbjct: 401 GTYYEKETKECRDCHKSCLTCSSS-----GTCTTCQKGLIMNPRGSCMANEKCSPSEYWD 455
Query: 853 ERG-ACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLD-DNHVCQPCN 910
E CK CH C C G C +C N +L +T TC C G+Y D D++ C C+
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNT-TCVKDCPEGYYADEDSNRCAHCH 514
Query: 911 THCGSCDSQAS--CTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGP 968
+ C +C+ + S C SCR P L EC + C YY D ST C+ C+ SC C GP
Sbjct: 515 SSCRTCEGRHSRQCHSCR-PGWFQLGKECLLQ-CREGYYADNSTGRCERCNRSCKGCQGP 572
Query: 969 LKTDCLQCMDGYVL--QDGACVEQCLSSFY--QDSGLC-KCDSYCLQCQGPH--ECTRCK 1021
TDCL C + L G C C +Y Q + C +C C QC+G C C
Sbjct: 573 RPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCV 632
Query: 1022 GPFLLLEAQCVQECGKGYF--ADHAKHKCTACPQGCLQCS--HRDRCHLCDHGFFL--KS 1075
+ L+ C +C G + + K C C + C++C C LC L
Sbjct: 633 WSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLVLHMDD 692
Query: 1076 GLCVYNC 1082
C++ C
Sbjct: 693 SHCLHCC 699
Score = 310 bits (795), Expect = 1e-83
Identities = 226/688 (32%), Positives = 304/688 (44%), Gaps = 91/688 (13%)
Query: 391 CYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWC 450
CY+ CP T + EV+ C C S +C +C Q+ C C++ LL G C
Sbjct: 60 CYKT----CPEKTYSEEVE---CKACDS-----NCGSCDQNG--CYWCEEGFFLL-GGSC 104
Query: 451 VHSCGLGFY--QAGSLCLACQPQCSTCTSGL--ECSSCQPPLLMRHGQCV---PTCGDG- 502
V CG GFY Q C +C C TCT ECSSCQ L + G CV T +G
Sbjct: 105 VRKCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGK 164
Query: 503 FYQD-RHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYN--RQGTCS 559
F+ D CH SC C G C +C ++L C SSC +G + R G+C
Sbjct: 165 FWNDILRKLQPCHSSCKTCNGSATL-CTSCPKGAYLLAQA-CVSSCPQGTWPSVRSGSCE 222
Query: 560 ACDQSCDSCGPSSPRCLTCTEKT----VLHDGKCMSECPGGYYADATGRCKVCHNSCASC 615
C ++C C + C C + LH+G+C S+CP G YA+ G C+ C + C +C
Sbjct: 223 NCTEACAICS-GADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAE-DGICERCSSPCRTC 280
Query: 616 SGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKK 675
G ++C +C L G C C E + GVCK C C C+ H CK+
Sbjct: 281 EG-NATNCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCI-----HEKTCKE 334
Query: 676 --PEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDC- 732
PE L + C C FY +S C CH+ C C+G +C C
Sbjct: 335 CTPEFFLHDDM----------CHQSCPRGFYADSRH-CVPCHKDCLECSGPKADDCELCL 383
Query: 733 GPSHVLLDGQCLSQCPDGYFHQEGS--CTECHPTCRQCHGPLESDCISCYPHISLTNGNC 790
S VL DG CL +CP G ++++ + C +CH +C C C +C + + N
Sbjct: 384 ESSWVLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCSS--SGTCTTCQKGLIM---NP 438
Query: 791 RTSCREEQFLNLVGY-------CADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCV 843
R SC + + Y C CH C HC + C + LLL CV
Sbjct: 439 RGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTC----PMNSLLLNTTCV 494
Query: 844 PDCPSGYYAERGA--CKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYLD 901
DCP GYYA+ + C CHSSCRTC+GR C SC C C G+Y D
Sbjct: 495 KDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGW-FQLGKECLLQCREGYYAD 553
Query: 902 DNHV-CQPCNTHCGSCDSQ--ASCTSCRDPNKVLLF--GECQYESCAPQYYLDFSTNTCK 956
++ C+ CN C C C SC D LL GEC + SC YY++ ST TC+
Sbjct: 554 NSTGRCERCNRSCKGCQGPRPTDCLSC-DRFFFLLRSKGEC-HRSCPDHYYVEQSTQTCE 611
Query: 957 ECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQ----DSGLC-KCDSYCLQC 1011
C +C C G +CL C+ Y L G C CL Y+ + C KC C++C
Sbjct: 612 RCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMEC 671
Query: 1012 QGP--HECTRCKGPFLLL--EAQCVQEC 1035
+GP CT C +L ++ C+ C
Sbjct: 672 KGPGAKNCTLCPANLVLHMDDSHCLHCC 699
Score = 305 bits (782), Expect = 5e-82
Identities = 181/616 (29%), Positives = 271/616 (43%), Gaps = 51/616 (8%)
Query: 495 CVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNR 554
C TC + Y + C C +C C + C C + +L G C CG GFY
Sbjct: 60 CYKTCPEKTYSEEVECKACDSNCGSC---DQNGCYWCEEGFFLL-GGSCVRKCGPGFYGD 115
Query: 555 Q--GTCSACDQSCDSC-GPSSPRCLTCTEKTVLHDGKCM----SECPGGYYADATGRCKV 607
Q G C +C ++C++C GP C +C E L G C+ ++ G ++ D + +
Sbjct: 116 QEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQP 175
Query: 608 CHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD--HGVCKACHSSCLACMGP 665
CH+SC +C+G + + CT+C L C+ C +G + G C+ C +C C G
Sbjct: 176 CHSSCKTCNG-SATLCTSCPKGAYLLAQACVSSCPQGTWPSVRSGSCENCTEACAICSG- 233
Query: 666 APSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKS 725
CKK Q++ + + G C ++C Y E GICE C C C G +
Sbjct: 234 ----ADLCKK----CQMQPGHPLFLHEGRCYSKCPEGSYAED-GICERCSSPCRTCEGNA 284
Query: 726 PHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISL 785
NC C HVL G C CP+ + +G C C C+ C E C C P L
Sbjct: 285 T-NCHSCEGGHVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCIH--EKTCKECTPEFFL 341
Query: 786 TNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD 845
+ C SC + + +C CH C C+ + +CL + ++L C+ +
Sbjct: 342 HDDMCHQSCPRGFYADS-RHCVPCHKDCLECSGPKADDCELCLE---SSWVLYDGLCLEE 397
Query: 846 CPSGYYAERGA--CKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTT--CFPGHYLD 901
CP+G Y E+ C+ CH SC TC G +C++C L+++ G+C C P Y D
Sbjct: 398 CPAGTYYEKETKECRDCHKSCLTCSSSG--TCTTCQKGLIMNPRGSCMANEKCSPSEYWD 455
Query: 902 DNHV-CQPCNTHCGSC--DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC 958
++ C+PC+ C C ++ C +C P LL + C YY D +N C C
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTC--PMNSLLLNTTCVKDCPEGYYADEDSNRCAHC 513
Query: 959 DWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQD--SGLC-KCDSYCLQCQGPH 1015
SC C G C C G+ C+ QC +Y D +G C +C+ C CQGP
Sbjct: 514 HSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPR 573
Query: 1016 --ECTRCKGPFLLL--EAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRD--RCHLCDH 1069
+C C F LL + +C + C Y+ + + C C C QC + C C
Sbjct: 574 PTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVW 633
Query: 1070 GFFLKSGLCVYNCVPG 1085
+ L G+C +C+ G
Sbjct: 634 SYHLMGGICTSDCLVG 649
Score = 299 bits (766), Expect = 3e-80
Identities = 176/576 (30%), Positives = 262/576 (45%), Gaps = 42/576 (7%)
Query: 540 DGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYA 599
D C +C + Y+ + C ACD +C SC + C C E L G C+ +C G+Y
Sbjct: 57 DHHCYKTCPEKTYSEEVECKACDSNCGSCDQNG--CYWCEEGFFLLGGSCVRKCGPGFYG 114
Query: 600 D-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRC---GEG-FYSD-HGVCK 653
D G C+ CH +C +C+GP C++C L +G C+ EG F++D +
Sbjct: 115 DQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQ 174
Query: 654 ACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQC-RAHFYLESTGICE 712
CHSSC C G A + CT C K + + C++ C + + +G CE
Sbjct: 175 PCHSSCKTCNGSA-TLCTSCPK-----------GAYLLAQACVSSCPQGTWPSVRSGSCE 222
Query: 713 ACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTECHPTCRQCHG 770
C ++C C+G P H L +G+C S+CP+G + ++G C C CR C G
Sbjct: 223 NCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEG 282
Query: 771 PLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRC 830
++C SC L +G C+ +C E+ + + G C C +CQ C + C C
Sbjct: 283 N-ATNCHSCEGGHVLHHGVCQENC-PERHVAVKGVCKHCPEMCQDCIHE-----KTCKEC 335
Query: 831 QNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC 890
+ L D C CP G+YA+ C CH C C G C C + + + G C
Sbjct: 336 -TPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYDGLC 394
Query: 891 STTCFPGHYLD-DNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQ-YESCAPQYYL 948
C G Y + + C+ C+ C +C S +CT+C+ + G C E C+P Y
Sbjct: 395 LEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYW 454
Query: 949 DFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFY--QDSGLC-KCD 1005
D CK C C C GP + C C +L + CV+ C +Y +DS C C
Sbjct: 455 DEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCH 514
Query: 1006 SYCLQCQGPH--ECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCS--HR 1061
S C C+G H +C C+ + L +C+ +C +GY+AD++ +C C + C C
Sbjct: 515 SSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQGPRP 574
Query: 1062 DRCHLCDHGFFL--KSGLCVYNCVPGFSVHTSNETC 1095
C CD FFL G C +C + V S +TC
Sbjct: 575 TDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTC 610
Score = 259 bits (663), Expect = 3e-68
Identities = 179/648 (27%), Positives = 243/648 (37%), Gaps = 74/648 (11%)
Query: 260 RCGKGQSRARRHGQC------CEECVSPA---------------GSCSYDGVVRYQDEMW 298
+CG G + G+C CE C P G C + + + + W
Sbjct: 107 KCGPGFYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFW 166
Query: 299 KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFM 358
+ C TC C + L+ C+S +
Sbjct: 167 NDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLL------AQACVSSCPQGTWPSVRSGS 220
Query: 359 SSNASEVKRIPEGEKWEDGPCKVCECR-GAQVTCYEPSC-PPCPVGTLALEVKGQCCPDC 416
N +E I G CK C+ + G + +E C CP G+ A + C C
Sbjct: 221 CENCTEACAICSGADL----CKKCQMQPGHPLFLHEGRCYSKCPEGSYA---EDGICERC 273
Query: 417 TSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCT 476
+S C TC + +C C+ +L +G C +C +C C C C
Sbjct: 274 SS-----PCRTCEGNATNCHSCEGG-HVLHHGVCQENCPERHVAVKGVCKHCPEMCQDCI 327
Query: 477 SGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLH 536
C C P + C +C GFY D C CH+ C C GP C C +
Sbjct: 328 HEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSW 387
Query: 537 VLRDGGCESSCGKGFYNRQGT--CSACDQSCDSCGPSSPRCLTCTEKTVLHD-GKCMSE- 592
VL DG C C G Y + T C C +SC +C SS C TC + +++ G CM+
Sbjct: 388 VLYDGLCLEECPAGTYYEKETKECRDCHKSCLTCS-SSGTCTTCQKGLIMNPRGSCMANE 446
Query: 593 --CPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDH- 649
P Y+ + CK CH C C GP C C L C+ C EG+Y+D
Sbjct: 447 KCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTCPMNSLLLNTTCVKDCPEGYYADED 506
Query: 650 -GVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLE-S 707
C CHSSC C G C C+ L ECL QCR +Y + S
Sbjct: 507 SNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQL-----------GKECLLQCREGYYADNS 555
Query: 708 TGICEACHQSCFRCAGKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEG--SCTECHP 763
TG CE C++SC C G P +C C LL G+C CPD Y+ ++ +C CHP
Sbjct: 556 TGRCERCNRSCKGCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHP 615
Query: 764 TCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVG---YCADCHHLCQHCAADL 820
TC QC G +C+SC L G C + C ++ G C CH C C
Sbjct: 616 TCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGP- 674
Query: 821 HNTGSICLRCQNAHYLLLGD-HCVPDCPSGYYAERGACKKCHSSCRTC 867
C C L + D HC+ C + C C + C
Sbjct: 675 --GAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDEC 720
Score = 172 bits (435), Expect = 8e-42
Identities = 165/634 (26%), Positives = 231/634 (36%), Gaps = 108/634 (17%)
Query: 84 CPECVLRTPGSCHHEKKIHEHGTEWAS-----SPC--SVCSCNHGEVRCTPQPCPPLSCG 136
C E + G C H K E G W PC S +CN CT P
Sbjct: 142 CQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLA 201
Query: 137 HQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQP 196
++ P+G+ V G + C+ E G D C KC + G P
Sbjct: 202 QACVSSCPQGTWPSVRSGSCENCT-EACAICSGAD----LCKKCQMQPG---------HP 247
Query: 197 LFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQAC 256
LF ++ G+C +C S + G + + C T C+ CH
Sbjct: 248 LFLHE--------GRCYSKCPEGSYAEDGIC-----ERCSSPCRT--CEGNATNCHS--- 289
Query: 257 LPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQ 316
C G HG C E C P + GV ++ EM C+ C+ + TC+
Sbjct: 290 ----CEGG--HVLHHGVCQENC--PERHVAVKGVCKHCPEM-----CQDCI---HEKTCK 333
Query: 317 TGECAKVECARDEEL-------IHLDGK----CCPECISRNG----YCVYEETGEFMSSN 361
EC D+ + D + C +C+ +G C ++ +
Sbjct: 334 --ECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYD 391
Query: 362 ASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEP-SCPPCPVGTLALEVKGQC-------- 412
++ P G +E + +C + +TC +C C G L + +G C
Sbjct: 392 GLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKG-LIMNPRGSCMANEKCSP 450
Query: 413 -------CPDCTSVHCHPDCLTC-SQSPDHCDLCQDPTKLLQNGWCVHSCGLGFY--QAG 462
P C CH C C + D C C LL N CV C G+Y +
Sbjct: 451 SEYWDEDAPGCKP--CHVKCFHCMGPAEDQCQTC-PMNSLLLNTTCVKDCPEGYYADEDS 507
Query: 463 SLCLACQPQCSTCTS--GLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
+ C C C TC +C SC+P +C+ C +G+Y D + C C+ SC
Sbjct: 508 NRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCK 567
Query: 519 GCWGPTEKHCLACRDPLHVLRD-GGCESSCGKGFYNRQG--TCSACDQSCDSC-GPSSPR 574
GC GP CL+C +LR G C SC +Y Q TC C +CD C G +
Sbjct: 568 GCQGPRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALN 627
Query: 575 CLTCTEKTVLHDGKCMSECPGGYYADATG---RCKVCHNSCASCSGPTPSHCTACSPPKA 631
CL+C L G C S+C G Y G C+ CH SC C GP +CT C
Sbjct: 628 CLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNCEKCHESCMECKGPGAKNCTLCPANLV 687
Query: 632 LR--QGHCLPRCGEGFYSDHGVCKACHSSCLACM 663
L HCL C C C + C+
Sbjct: 688 LHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECI 721
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 217 bits (553), Expect = 2e-55
Identities = 286/1151 (24%), Positives = 378/1151 (32%), Gaps = 324/1151 (28%)
Query: 44 DSCQSCRC-HGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIH 102
D C+ CRC G I CR +CA + CCP C C + H
Sbjct: 211 DPCRICRCLEGHIQ------CRQRECASLCPYPARPLPGTCCPVC-----DGCFLNGREH 259
Query: 103 EHGTEWASS-PCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSY 161
G S PCS C C +G V+C P PCPP+ C H IP G CCPVC G C Y
Sbjct: 260 RSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHP--GKIP-GQCCPVCDG----CEY 312
Query: 162 EGHVFQDGEDWRLSR---CAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSA 218
+GH +Q E +RL C +C C+ G C +C C +P C A
Sbjct: 313 QGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPC-------ALPASGRQLCPA 365
Query: 219 RSCSAAGQVYEHGEQWSENA--CTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCE 276
C G+ + G QW + CT C+C G +C C P C Q + G CC
Sbjct: 366 --CELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPC---QHPTQPPGACCP 420
Query: 277 ECVSPAGSCSYDGVVRYQDEMW--KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHL 334
C SC+Y V + + S C C C G VTC +C CAR +
Sbjct: 421 SC----DSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQS---G 473
Query: 335 DGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEP 394
G+CCP C C+ EE EV E PC+ C C+ C +P
Sbjct: 474 PGQCCPRCPD----CILEE----------EVFVDGESFSHPRDPCQECRCQEGHAHC-QP 518
Query: 395 SCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSC 454
PCP A + G CCP+ DC C+ G +
Sbjct: 519 R--PCPRAPCAHPLPGTCCPN--------DCSGCA-----------------FGGKEYPS 551
Query: 455 GLGFYQAGSLCLACQPQCSTCTSG-LECSS-------CQPPLLMRHGQCVPTCGDGFYQD 506
G F C C+ C SG ++C + C P+L+ G+C P C
Sbjct: 552 GADFPHPSDPCRLCR-----CLSGNVQCLARRCVPLPCPEPVLL-PGECCPQCPAPAGCP 605
Query: 507 RHSCA-VCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSC 565
R A H+ G + CL + R + C + RQG C SC
Sbjct: 606 RPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCA---HPRQGPCC---PSC 659
Query: 566 DSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCK--VCHNSCASCSGPTPSHC 623
D C L+ GK + G + T C +C SC P C
Sbjct: 660 DGC---------------LYQGKEFAS--GERFPSPTAACHLCLCWEGSVSCE---PKAC 699
Query: 624 TACSPPKALRQGHCLPRC------GEGFYSDHGV------CKACHSSCL---ACMGPAPS 668
P R G C P C GE + S+ C C +CL G P
Sbjct: 700 APALCPFPAR-GDCCPDCDGCEYLGESYLSNQEFPDPREPCNLC--TCLGGFVTCGRRPC 756
Query: 669 HCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFY--------------LESTGICEAC 714
GC P IPSG C C+ Y L+ T C
Sbjct: 757 EPPGCSHPL------------IPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTC 804
Query: 715 HQSCFRCAGK------SPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEG------------ 756
+ RC K PH GP + CLSQ G HQ+G
Sbjct: 805 QEGSMRCQKKPCPPALCPH--PSPGPCFCPVCHSCLSQ---GREHQDGEEFEGPAGSCEW 859
Query: 757 --------SCT-----------------ECHPTCRQC--HG----------PLESDCISC 779
SC C P CR C HG P +S C SC
Sbjct: 860 CRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGSRWVPPDSACSSC 919
Query: 780 YPH---ISLTNGNCRTSCREEQF--LNLVGYCADCHH----------------LCQHCAA 818
H ++ C +SC + + + C+DC H C+ C
Sbjct: 920 VCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCIC 979
Query: 819 DLHNTGSICLRCQNAHY-LLLG-----------DHCVPDCPSGYYAERGACKKCHSSCRT 866
+ G LRC L+G HC P C A C
Sbjct: 980 EPQPEGPPSLRCHRRQCPSLVGCPPSQLLPPGPQHCCPTCAE-------ALSNCSEGLLG 1032
Query: 867 CQGRGPFSCSSC---DTNLVLSHTGTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCT 923
+ P C +C D + H +C L + H T GSC C
Sbjct: 1033 SELAPPDPCYTCQCQDLTWLCIHQACPELSC----PLSERH------TPPGSC-----CP 1077
Query: 924 SCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCM------ 977
CR P + C ++ ++ +TC SCS +G ++ +C
Sbjct: 1078 VCRAPTQ-----SCVHQGREVASGERWTVDTCT----SCSCMAGTVRCQSQRCSPLSCGP 1128
Query: 978 -DGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECTRCKGPFLLLEAQC----V 1032
L G+C +CL + C+ PH T G L + C
Sbjct: 1129 DKAPALSPGSCCPRCLPR----------PASCMAFGDPHYRT-FDGRLLHFQGSCSYVLA 1177
Query: 1033 QECGKGYFADH 1043
++C G F+ H
Sbjct: 1178 KDCHSGDFSVH 1188
Score = 167 bits (424), Expect = 1e-40
Identities = 257/1030 (24%), Positives = 333/1030 (32%), Gaps = 280/1030 (27%)
Query: 150 PVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVP 209
P C GLG+ + +G W C C+C++G A C P
Sbjct: 94 PQCWGLGR-------AWPEGARWEPDACTACVCQDGAAHC------------------GP 128
Query: 210 GKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRAR 269
P C R CS GQ Y +GE +S +ACTTC C G V+C +C L C
Sbjct: 129 QAHLPHC--RGCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNC---LESCT 183
Query: 270 RHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDE 329
G+CC C + GS G Q+ G C C C G + C+ ECA + C
Sbjct: 184 PPGECCPICCTEGGSHWEHG----QEWTTPGDPCRICRCLEGHIQCRQRECASL-CPYPA 238
Query: 330 ELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDG-PCKVCECRGAQ 388
L G CCP C G F++ GE G PC C C
Sbjct: 239 R--PLPGTCCPVC-----------DGCFLNGREHR-----SGEPVGSGDPCSHCRCANGS 280
Query: 389 VTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNG 448
V C CPP P ++ GQCCP C + H Q+ +L + G
Sbjct: 281 VQCEPLPCPPVPCRHPG-KIPGQCCPVCDG----------CEYQGHQYQSQETFRLQERG 329
Query: 449 WCVH-SCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTC---GDGFY 504
CV SC QAG ++C+ Q EC L Q P C G+ F
Sbjct: 330 LCVRCSC-----QAGE--VSCEEQ--------ECPVTPCALPASGRQLCPACELDGEEFA 374
Query: 505 QDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQS 564
+ W P + C AC V +DG CG + C
Sbjct: 375 EGVQ------------WEPDGRPCTAC-----VCQDG--VPKCGAVLC----PPAPCQHP 411
Query: 565 CDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCH--NSCASCSGPTPSH 622
G P C +CT + ++ G + DA C CH + +CS
Sbjct: 412 TQPPGACCPSCDSCTYHSQVY-------ANGQNFTDADSPCHACHCQDGTVTCS-LVDCP 463
Query: 623 CTACSPPKALRQGHCLPRC------------GEGFYSDHGVCKAC-----HSSC------ 659
T C+ P++ G C PRC GE F C+ C H+ C
Sbjct: 464 PTTCARPQS-GPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCP 522
Query: 660 -LACMGP-----APSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEA 713
C P P+ C+GC G + +D PS C CR C +
Sbjct: 523 RAPCAHPLPGTCCPNDCSGC--AFGGKEYPSGADFPHPSDPC-RLCR----------CLS 569
Query: 714 CHQSCF--RCAGKSPHNCTDCGPSHVLLDGQCLSQCP----------DGYFHQEGSCTEC 761
+ C RC P C P VLL G+C QCP HQE
Sbjct: 570 GNVQCLARRCV---PLPC----PEPVLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPPG 622
Query: 762 HPTCRQC---HGPLESDCISC--YPHISLTNGNCRTSC-----------REEQFLNLVGY 805
P CR+C G + + C P G C SC E+F +
Sbjct: 623 DP-CRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAA 681
Query: 806 CADCHHLC-----------QHCAADL---HNTGSICLRCQNAHYL---LLGDHCVPDCPS 848
C HLC + CA L G C C YL L + PD
Sbjct: 682 C----HLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPD--- 734
Query: 849 GYYAERGACK--KCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHY-----LD 901
R C C TC GR P C L+ S G C TC Y
Sbjct: 735 ----PREPCNLCTCLGGFVTC-GRRPCEPPGCSHPLIPS--GHCCPTCQGCRYHGVTTAS 787
Query: 902 DNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYL------------- 948
+ P + C C Q C+ K C + S P +
Sbjct: 788 GETLPDPLDPTCSLCTCQEGSMRCQ--KKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQ 845
Query: 949 --DFSTNTCKECDWSCSACSGPLKTDCLQC----MDGYVLQDGACVEQCLSSFY------ 996
+ C+W C +G + LQC V + G+C +C
Sbjct: 846 DGEEFEGPAGSCEW-CRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHP 904
Query: 997 QDSGLCKCDSYCLQC---QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQ 1053
+ S DS C C +G C R QC+ C + H C CPQ
Sbjct: 905 EGSRWVPPDSACSSCVCHEGVVTCAR---------IQCISSCAQ---PRQGPHDC--CPQ 950
Query: 1054 GCLQCSHRDR 1063
C C H R
Sbjct: 951 -CSDCEHEGR 959
Score = 137 bits (345), Expect = 2e-31
Identities = 100/353 (28%), Positives = 131/353 (37%), Gaps = 40/353 (11%)
Query: 18 AVLPHHSEG--------ACVYQDSLLADATIWK--PDSCQSCRCHGDIVICKPAVCRNPQ 67
A+ PH S G +C+ Q D ++ SC+ CRC V C C
Sbjct: 819 ALCPHPSPGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLP 878
Query: 68 CAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWA--SSPCSVCSCNHGEVRC 125
C + E CCP C C + H G+ W S CS C C+ G V C
Sbjct: 879 CKLQVTE-----RGSCCPRC-----RGCLAHGEEHPEGSRWVPPDSACSSCVCHEGVVTC 928
Query: 126 TPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWR--LSRCAKCLCR 183
C SC CCP C C +EG ++ GE ++ C C+C
Sbjct: 929 ARIQCIS-SCAQPRQG---PHDCCPQC----SDCEHEGRKYEPGESFQPGADPCEVCICE 980
Query: 184 NGVA-----QCFTAQCQPLF-CNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSEN 237
+C QC L C + + P CCP C A + S + E +
Sbjct: 981 PQPEGPPSLRCHRRQCPSLVGCPPSQLLPPGPQHCCPTC-AEALSNCSEGLLGSELAPPD 1039
Query: 238 ACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEM 297
C TC C C QAC L C + R G CC C +P SC + G E
Sbjct: 1040 PCYTCQCQDLTWLCIHQACPELSCPLSE-RHTPPGSCCPVCRAPTQSCVHQGREVASGER 1098
Query: 298 WKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCV 350
W C C C G V CQ+ C+ + C D+ G CCP C+ R C+
Sbjct: 1099 WTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRPASCM 1151
Score = 133 bits (335), Expect = 3e-30
Identities = 88/265 (33%), Positives = 114/265 (43%), Gaps = 30/265 (11%)
Query: 43 PDS-CQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKI 101
PDS C SC CH +V C C + +G + CCP+C C HE +
Sbjct: 912 PDSACSSCVCHEGVVTCARIQCISSCAQPRQGP------HDCCPQC-----SDCEHEGRK 960
Query: 102 HEHGTEW--ASSPCSVCSCNHG-----EVRCTPQPCPPL-SCGHQELAFIPEGS--CCPV 151
+E G + + PC VC C +RC + CP L C +L +P G CCP
Sbjct: 961 YEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQL--LPPGPQHCCPT 1018
Query: 152 CVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGK 211
C CS EG + E C C C++ C C L C E PG
Sbjct: 1019 CAEALSNCS-EGLL--GSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTP-PGS 1074
Query: 212 CCPQCSA--RSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRAR 269
CCP C A +SC G+ GE+W+ + CT+C C G VRC Q C PL CG ++ A
Sbjct: 1075 CCPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPAL 1134
Query: 270 RHGQCCEECVSPAGSCSYDGVVRYQ 294
G CC C+ SC G Y+
Sbjct: 1135 SPGSCCPRCLPRPASCMAFGDPHYR 1159
Score = 82.0 bits (201), Expect = 1e-14
Identities = 44/132 (33%), Positives = 54/132 (40%), Gaps = 4/132 (3%)
Query: 43 PDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIH 102
PD C +C+C +C C C + CCP C T SC H+ +
Sbjct: 1038 PDPCYTCQCQDLTWLCIHQACPELSCPLSERHT---PPGSCCPVCRAPTQ-SCVHQGREV 1093
Query: 103 EHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYE 162
G W C+ CSC G VRC Q C PLSCG + + GSCCP C+ C
Sbjct: 1094 ASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRPASCMAF 1153
Query: 163 GHVFQDGEDWRL 174
G D RL
Sbjct: 1154 GDPHYRTFDGRL 1165
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 206 bits (523), Expect = 5e-52
Identities = 204/749 (27%), Positives = 260/749 (34%), Gaps = 180/749 (24%)
Query: 18 AVLPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQ 77
A LPH C + + PD+C +CRC + C C C E G
Sbjct: 130 AHLPHCR--GCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCP-EPG---- 182
Query: 78 IAANQCCPECVLRTPGSCHHEKKIHEHGTEWASS--PCSVCSCNHGEVRCTPQPCPPLSC 135
CCP C PG C +E +++E G + SS PC C+C VRC CPP C
Sbjct: 183 ----ACCPHC---KPG-CDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPC 234
Query: 136 GHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRL--SRCAKCLCRNGVAQCFTAQ 193
L G CCP C G C+ G ++ G++W C C C G QC +
Sbjct: 235 PEPVLR---PGHCCPTCQG----CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRE 287
Query: 194 CQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQ-WSENACTTCICDRGEVRCH 252
C L C +PG CCP C C G+ + GE S + C+ C C G V+C
Sbjct: 288 CASL-CPYPAR--PLPGTCCPVCD--GCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCE 342
Query: 253 KQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDE----MWKGSACEFCMC 308
C P+ C + + GQCC C C Y G +YQ + + + C C C
Sbjct: 343 PLPCPPVPC---RHPGKIPGQCCPVC----DGCEYQG-HQYQSQETFRLQERGLCVRCSC 394
Query: 309 DHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRI 368
G+V+C+ EC CA L + CP C E GE
Sbjct: 395 QAGEVSCEEQECPVTPCA----LPASGRQLCPAC---------ELDGE----------EF 431
Query: 369 PEGEKWE-DG-PCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCL 426
EG +WE DG PC C C+ C CPP P + G CCP C S H
Sbjct: 432 AEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPC-QHPTQPPGACCPSCDSCTYHSQ-- 488
Query: 427 TCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQP 486
V++ G F A S C AC Q T T L C P
Sbjct: 489 ------------------------VYANGQNFTDADSPCHACHCQDGTVTCSL--VDCPP 522
Query: 487 PLLMR----HGQCVPTC------------GDGFYQDRHSCAVC-----HESC-------A 518
R GQC P C G+ F R C C H C A
Sbjct: 523 TTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRA 582
Query: 519 GCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRC--L 576
C P C C + GG E G F + C C + + RC L
Sbjct: 583 PCAHPLPGTC--CPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPL 640
Query: 577 TCTEKTVLHDGKCMSECPGG------------------YYADATGRCK--VCHNSCASCS 616
C E VL G+C +CP Y++ C+ +C + SC
Sbjct: 641 PCPE-PVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQ 699
Query: 617 GPTPSHCTACSPPKALRQGHCLPRC------------GEGFYSDHGVCKAC--------- 655
P C+ P RQG C P C GE F S C C
Sbjct: 700 -RLPCPPAPCAHP---RQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSC 755
Query: 656 -HSSCLACMGPAPSH---CTGCKKPEEGL 680
+C + P P+ C C G+
Sbjct: 756 EPKACAPALCPFPARGDCCPDCDGEGHGI 784
Score = 89.0 bits (219), Expect = 9e-17
Identities = 180/765 (23%), Positives = 232/765 (30%), Gaps = 189/765 (24%)
Query: 369 PEGEKWEDGPCKVCECRGAQVTC----YEPSCPPCPVGTLALEVKGQCCPD-CTSVHCHP 423
PEG +WE C C C+ C + P C C PD CT+ C
Sbjct: 104 PEGARWEPDACTACVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTTCRCLE 163
Query: 424 DCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLG------FYQAGSLCLACQPQCSTCTS 477
+TC+Q P C +P G C C G Y+ G L+ C CT
Sbjct: 164 GTITCNQKPCPRGPCPEP------GACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTC 217
Query: 478 --------GLEC--SSCQPPLLMRHGQCVPTC------------GDGFYQDRHSCAVCH- 514
L+C S C P+L R G C PTC G + C +C
Sbjct: 218 LRSRVRCMALKCPPSPCPEPVL-RPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRC 276
Query: 515 -ESCAGCWGPTEKHCLA-CRDPLHVLRDGGCESSCGKGFYN----RQGTCSACDQSCDSC 568
E C ++ C + C P L G C C F N R G C C
Sbjct: 277 LEGHIQC---RQRECASLCPYPARPL-PGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHC 332
Query: 569 --GPSSPRC--LTCTEKTVLHDGK----CMSECPG------GYYADATGR---------- 604
S +C L C H GK C C G Y + T R
Sbjct: 333 RCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRC 392
Query: 605 -CKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRC---GEGFYS------DHGVCKA 654
C+ SC P T C+ P + RQ P C GE F D C A
Sbjct: 393 SCQAGEVSCEEQECPV----TPCALPASGRQ--LCPACELDGEEFAEGVQWEPDGRPCTA 446
Query: 655 CHSS-----CLACM-GPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFY---- 704
C C A + PAP C+ P + P G C C + Y
Sbjct: 447 CVCQDGVPKCGAVLCPPAP-----CQHPTQ------------PPGACCPSCDSCTYHSQV 489
Query: 705 -------LESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLD----GQCLSQCPD---- 749
++ C ACH G + DC P+ GQC +CPD
Sbjct: 490 YANGQNFTDADSPCHACHCQ----DGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILE 545
Query: 750 --------GYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNC-RTSCREEQFL 800
+ H C EC C++ H C P C R C
Sbjct: 546 EEVFVDGESFSHPRDPCQECR--CQEGHA-------HCQPR------PCPRAPCAHP--- 587
Query: 801 NLVGYCADCHHLCQHCA---------ADLHNTGSIC--LRCQNAHYLLLGDHCVP-DCPS 848
L G C C + C CA AD + C RC + + L CVP CP
Sbjct: 588 -LPGTC--CPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPE 644
Query: 849 GYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC-STTCFPGHYLDDNHVCQ 907
C +C ++ P + + C C G C
Sbjct: 645 PVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCP 704
Query: 908 PCN-THCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSA-- 964
P H SC C K GE ++ S +L C+ A
Sbjct: 705 PAPCAHPRQGPCCPSCDGCLYQGKEFASGE-RFPSPTAACHLCLCWEGSVSCEPKACAPA 763
Query: 965 -CSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYC 1008
C P + DC DG +G + C + GL + + YC
Sbjct: 764 LCPFPARGDCCPDCDG----EGHGIGSCRGGMRETRGLGQNNLYC 804
Score = 34.3 bits (77), Expect = 2.6
Identities = 46/208 (22%), Positives = 62/208 (29%), Gaps = 48/208 (23%)
Query: 905 VCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSA 964
VCQ HCG C C + GE FS + C +C
Sbjct: 118 VCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGET------------FSPDACT----TCRC 161
Query: 965 CSGPLKTDCLQCMDGYVLQDGACVEQCL------SSFYQDS-GLCKCDSYCLQCQGPHEC 1017
G + + C G + GAC C Y++ + CLQC
Sbjct: 162 LEGTITCNQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSR 221
Query: 1018 TRCKG----------PFLLLEAQC--VQECGKGYFADHAKH-----------KCTACPQG 1054
RC P L C Q C +G H +H + C +G
Sbjct: 222 VRCMALKCPPSPCPEPVLRPGHCCPTCQGCTEG--GSHWEHGQEWTTPGDPCRICRCLEG 279
Query: 1055 CLQCSHRDRCHLCDHGFFLKSGLCVYNC 1082
+QC R+ LC + G C C
Sbjct: 280 HIQCRQRECASLCPYPARPLPGTCCPVC 307
Score = 32.3 bits (72), Expect = 9.7
Identities = 54/251 (21%), Positives = 80/251 (31%), Gaps = 67/251 (26%)
Query: 841 HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYL 900
HC P A C+ C + +T FS +C T L T TC+
Sbjct: 125 HCGPQ------AHLPHCRGCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQ-------- 170
Query: 901 DDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDF--STNTCKEC 958
+PC G C +C P C YE + + F S+N C +
Sbjct: 171 ------KPCPR--GPCPEPGACCPHCKPG-------CDYEGQLYEEGVTFLSSSNPCLQ- 214
Query: 959 DWSCSACSGPLKTDCLQCMDG----YVLQDGACVEQCLSSFYQDS--------------- 999
C+ ++ L+C VL+ G C C S
Sbjct: 215 ---CTCLRSRVRCMALKCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPC 271
Query: 1000 GLCKCDSYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHK----------CT 1049
+C+C +QC+ + C P L C C G F + +H+ C+
Sbjct: 272 RICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVC-DGCFLNGREHRSGEPVGSGDPCS 330
Query: 1050 --ACPQGCLQC 1058
C G +QC
Sbjct: 331 HCRCANGSVQC 341
>gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens]
Length = 2322
Score = 172 bits (437), Expect = 5e-42
Identities = 295/1326 (22%), Positives = 523/1326 (39%), Gaps = 161/1326 (12%)
Query: 1139 FHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRF---VHSKEKLRKGYLFLKI 1195
+ VV P G L L + +L F+ D+ +V + + E + + F ++
Sbjct: 823 YEVVQAPRKGNLQL----QGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRF-RV 877
Query: 1196 SDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNPQDVVIEI 1255
+ +FS I VL N +L + G ++ L ++ N + E+
Sbjct: 878 TAPPYFSPLYTFPIHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSL-NSASYLYEV 936
Query: 1256 IDPPLHGQLL-QTLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSD-VAVLQANDGHSFH 1313
++ P HG+L + Q T + F ++L RG L Y HD S++T D + + G S
Sbjct: 937 MERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSG 996
Query: 1314 NI-------LFQVKTVPQNDRGLQLVANSMVWVPEGGM-LQITNRILQAEAPGASAEEII 1365
++ +F+V P ND + + V GG L T+ + ++A A+ +
Sbjct: 997 DMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQL 1056
Query: 1366 YKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGA 1425
+D FG +V + D P P FTQ+D+ + V + HSGA
Sbjct: 1057 VLTRKDL-LFGSIVAV-----DEPT------------RPIYRFTQEDLRKRRVLFVHSGA 1098
Query: 1426 PAQSDSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQP 1485
+ +VS + T A+L P + + + + G I
Sbjct: 1099 --DRGWIQLQVSDGQHQAT---------ALLEVQASEPYLRVANGSSLVVPQGGQGTIDT 1147
Query: 1486 HSLSF-INSEKPSG-KIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPP 1543
L N + SG ++ Y++T P G + P + F+Q+D+ G V+Y
Sbjct: 1148 AVLHLDTNLDIRSGDEVHYHVTAG--PRWGQLVRAGQPATA---FSQQDLLDGAVLYSHN 1202
Query: 1544 PAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRL 1603
+ ++ MAFS P HT + +TI L P+ V ++
Sbjct: 1203 GSLSP-RDTMAFSVEAGPV------------HTDATLQVTIAL--EGPLAPLKLVRHKKI 1247
Query: 1604 AVSPGGSTSVGL-QVVVRDAETAPKELFFELRRPPQHGVLLKHT----AEFRRPMATGDT 1658
V G + + Q+ P ++ F ++ PP G L+ + A+ + +
Sbjct: 1248 YVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQS 1307
Query: 1659 FTYEDVEKNALQYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSL 1718
F+ E V+ + Y+H D+ + V GL + V VE+ + P A S+
Sbjct: 1308 FSQEAVDTGRVLYLHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSV 1367
Query: 1719 SITVASKSTAIITRSHLAYVDDSSPDPEIWIQLNYL--PSYGTLLRISGSEVEELSEVSN 1776
+ ++ L V + + L L P +G L + G + LS
Sbjct: 1368 P-----EGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSA--- 1419
Query: 1777 FTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQI-FTIMITPAENPPPVI 1835
F+ + + IRY +TDSF + + + + + FT+ + P + PP++
Sbjct: 1420 FSWRMVEEQLIRY---VHDGSETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPIL 1476
Query: 1836 AFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPET 1895
+ + EG AP+ +TD D + D + + P G + G G E
Sbjct: 1477 TTNTGLQMWEGATAPIPAEALRSTDGDSGSE-DLVYTIEQ-PSNGRVVLRGAP---GTEV 1531
Query: 1896 ASDLEASFPIQDVLENYIYYFQSVHESIEPTHDI-FSFYVSDGTSRSEIHSINITIERKN 1954
S +A L+ + F S T D F F +SDG S H +T +++
Sbjct: 1532 RSFTQAQ------LDGGLVLF-----SHRGTLDGGFRFRLSDGEHTSPGHFFRVTAQKQV 1580
Query: 1955 ----DEPPRMTLQPLRVQ-LSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQ 2009
+T+ P VQ LSS + ++SS T L++ + + P G + Q
Sbjct: 1581 LLSLKGSQTLTVCPGSVQPLSSQTLRASSSAG-----TDPQLLLYRVVRGPQLGRLFHAQ 1635
Query: 2010 TASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGR---- 2065
S G LV FT ++ AG + Y +P E +L L R
Sbjct: 1636 QDS----TGEALVN---FTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAA 1688
Query: 2066 ---MKIYTELPASDTP-HLAINQGLQLSAGSVARITEQHLKVTDI-------DSDDHQVM 2114
+ + E P HL N+GL + G ARIT L +++ +H V+
Sbjct: 1689 TLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVL 1748
Query: 2115 YIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSHGTG-EPGGSFAFKF 2173
+ + + P G+L + + E + P F Q+ ++ GQ Y+HG G F F+
Sbjct: 1749 FQVTQFPSRGQLLVSE----EPLHAGQP--HFLQSQLAAGQLVYAHGGGGTQQDGFHFRA 1802
Query: 2174 DVVDGEGNRLI----DKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQD 2228
+ G + ++F+I++ + ++ PP + L L S I+ QLS D D
Sbjct: 1803 HLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPD 1862
Query: 2229 SGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFT 2288
S P E+ Y + R P G L ++ FTQAD+ S + +V + + F +
Sbjct: 1863 SAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLS 1920
Query: 2289 LSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGM-RKTITEFELKAVDADTEAESVT 2347
+SDG S + + + ++ V + V + + R ++++ +L+ V +D E
Sbjct: 1921 MSDGASP-PLPMSLAVDILPSAIEVQLRAPLEVPQALGRSSLSQQQLRVV-SDREEPEAA 1978
Query: 2348 FTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRF-TFTVSDGT 2406
+ ++Q P++G + G+ TS F+ I Q V ++ +S D F ++ G
Sbjct: 1979 YRLIQGPQYGHL--LVGGRP---TSAFSQFQIDQGEVVFAFTNFSSSHDHFRVLALARGV 2033
Query: 2407 NPFFII 2412
N ++
Sbjct: 2034 NASAVV 2039
Score = 171 bits (432), Expect = 2e-41
Identities = 287/1256 (22%), Positives = 496/1256 (39%), Gaps = 208/1256 (16%)
Query: 1330 QLVANSMVWVPEGGMLQITNRILQAEAPGASAE----EIIYKITQDYPQFGEVVLLVNMP 1385
QL+ S + V EGG + R +Q AE ++++ +T+ + GE+ L
Sbjct: 430 QLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRG-ARHGELEL----- 483
Query: 1386 ADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVSSASNAQT- 1444
D P + + + FT D+ + H G+ SD EVS +
Sbjct: 484 -DIPGAQARKM-----------FTLLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMP 531
Query: 1445 ----RLESHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKI 1500
R ++++ I + P H+ L VI H+ +KP G
Sbjct: 532 SCLRRGQTYLLPIQVNPVNDPP---------HIIFPHGSLMVILEHT------QKPLGPE 576
Query: 1501 VYNITLPLHPNQGI------------IEHRDHPHSPIRYFTQEDINQGKVMY--RPPPAA 1546
V+ P +G+ +E RD P P F+ ++ G ++Y R PA
Sbjct: 577 VFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA- 635
Query: 1547 PHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVL-TIHLLPSDQQLPVFQVTAPRLAV 1605
Q+L F VSDG SP L + + P+ Q + + T RLA
Sbjct: 636 ---QDLT--------------FRVSDGLQASPPATLKVVAIRPAIQ---IHRSTGLRLAQ 675
Query: 1606 SPGGSTSVGLQVVVRDAETAPKELFFELRRPPQHGVLLKHTA---EFRRPMATGDTFTYE 1662
V +A + F + Q G L K A E AT F
Sbjct: 676 GSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWAT-QAFHQR 734
Query: 1663 DVEKNALQYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITV 1722
DVE+ ++Y+ ST + L LEV+V G + + S +T+
Sbjct: 735 DVEQGRVRYL----STDPQHHAYDTVENLA---LEVQV--------GQEILSNLSFPVTI 779
Query: 1723 ASKSTAII---------------TRSHL-AYVDDSSPDPEIW-IQLNYLPSYGTLLRISG 1765
+ ++ T +HL A ++++ P P + ++ P G L ++ G
Sbjct: 780 QRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGNL-QLQG 838
Query: 1766 SEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLDNQIFTIMI 1825
+ LS+ FT +DI ++ Y A V D+F F V+ + + ++T I
Sbjct: 839 TR---LSDGQGFTQDDIQAGRVTYGATARAS-EAVEDTFRFRVTAPPYF---SPLYTFPI 891
Query: 1826 TPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENT 1885
+P + L+ V EGG LS H F + + ++ P++G +
Sbjct: 892 HIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNS---ASYLYEVMERPRHGRLAWR 948
Query: 1886 GTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYV------SDGTS 1939
GT D+ + + SF +D+L + Y H+ E T D F S +
Sbjct: 949 GTQDK------TTMVTSFTNEDLLRGRLVY---QHDDSETTEDDIPFVATRQGESSGDMA 999
Query: 1940 RSEIHSI-NITIERKNDEPPRMTLQPL-RVQLSSGVVISNSSLSLQDLDTPDNELIFVLT 1997
E+ + + I+ ND P T+ + V +++ ++ D D+ + VLT
Sbjct: 1000 WEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLT 1059
Query: 1998 KKPD-HGHVLWRQTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLT 2056
+K G ++ + P+ FT +D+ V +V S G Q ++
Sbjct: 1060 RKDLLFGSIVAVDEPTRPIYR---------FTQEDLRKRRVLFVHS--GADRGWIQLQVS 1108
Query: 2057 DGLHVDTGRMKIYTELP---ASDTPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQV 2113
DG H T +++ P ++ L + QG Q + + + +L DI S D +V
Sbjct: 1109 DGQHQATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNL---DIRSGD-EV 1164
Query: 2114 MYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFK 2172
Y + P G Q+++ G P +F+Q D+ G YSH G+ P + AF
Sbjct: 1165 HYHVTAGPRWG--QLVRAGQ--------PATAFSQQDLLDGAVLYSHNGSLSPRDTMAFS 1214
Query: 2173 FDVVDGEGNRLIDKSFSISI-LEDKSPPV-ITTNKGLVLDENSVKKITTLQLSATDQDSG 2230
+ G D + ++I LE P+ + +K + + + +I QL A +
Sbjct: 1215 VEA----GPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVP 1270
Query: 2231 PTELIYRITRQPQLGHLEHAASPGIQ--------ISSFTQADLTSRNVQYVHSSEAEKHS 2282
P ++++ + P G+L + + + SF+Q + + V Y+HS E S
Sbjct: 1271 PADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS-RPEAWS 1329
Query: 2283 DAFSFTLSDGVSEVTQTFHITLHPVDDSLPV-VQNLGMRVQEGMRKTITEFELKAVDADT 2341
DAFS ++ G+ + + L + ++P+ QN V EG T+ L+
Sbjct: 1330 DAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFS--VPEGGSLTLAPPLLRVSGPYF 1387
Query: 2342 EAE-SVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTF 2400
++ +++PP+HG +++ +G S F+ + + + + Y HDGS +L D F
Sbjct: 1388 PTLLGLSLQVLEPPQHGALQK-EDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFV- 1445
Query: 2401 TVSDGTNPFFIIEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNL 2460
++ + + P F V +LPV+D P + TN GLQ E AT
Sbjct: 1446 ----------LMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWE----GATAP 1491
Query: 2461 ITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRY 2516
I + L + D D+ LVY I P +G V + PG +FTQ ++ GL+ +
Sbjct: 1492 IPAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLF 1546
Score = 156 bits (395), Expect = 3e-37
Identities = 334/1495 (22%), Positives = 571/1495 (38%), Gaps = 217/1495 (14%)
Query: 1110 LILPIGSI--------KPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQL 1161
+I P GS+ KPL + D + E L F V+ T + L ++
Sbjct: 555 IIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSG----LPVERRDQPG 610
Query: 1162 DKAGRFSWKDVNEKKVRFVHSKEKLRKGYLFLKISDQQFFSEPQLINIQAFSTQAPYVLR 1221
+ A FS +++ + +VH + L ++SD S P + + A A + R
Sbjct: 611 EPATEFSCRELEAGSLVYVHRGGPAQD--LTFRVSDGLQASPPATLKVVAIRP-AIQIHR 667
Query: 1222 NEVLHISRGERATITTQMLDIRDDDNPQDVVI--EIIDPPLHGQLLQ------------- 1266
+ L +++G I L + + QDV + + G+L +
Sbjct: 668 STGLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQKQGAGGVEGAEWWA 727
Query: 1267 TLQSPATPIYQFQLDELSRGLLHYAHDGSDSTSDVAVLQANDGHSF-HNILFQVKTVPQN 1325
T + Q ++ LS H+A+D T + L+ G N+ F V
Sbjct: 728 TQAFHQRDVEQGRVRYLSTDPQHHAYD----TVENLALEVQVGQEILSNLSFPVT----- 778
Query: 1326 DRGLQLVANSMVWVPEGGMLQ--------ITNRILQA--EAPGASAEEIIYKITQDYPQF 1375
+ + VW+ L +T L+A E G S Y++ Q P+
Sbjct: 779 ------IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQA-PRK 831
Query: 1376 GEVVLLVNMPADSPADEGQHLPDGRTATPTSTFTQQDINEGIVWYRHSGAPAQS--DSFR 1433
G + L +G L DG+ FTQ DI G V Y + +++ D+FR
Sbjct: 832 GNLQL-----------QGTRLSDGQG------FTQDDIQAGRVTYGATARASEAVEDTFR 874
Query: 1434 FEVSSASNAQTRLESHMFNIAI-LPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFIN 1492
F V++ S ++ I + P+AP ++ ++ + E G V+ L F+
Sbjct: 875 FRVTAPPYF-----SPLYTFPIHIGGDPDAPVLT---NVLLVVPEGGEGVLSADHL-FVK 925
Query: 1493 SEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQEL 1552
S + + + P H +D + + FT ED+ +G+++Y+ + ++
Sbjct: 926 SLNSASYLYEVMERPRHGRLAWRGTQDKT-TMVTSFTNEDLLRGRLVYQHDDSETTEDDI 984
Query: 1553 MAFSFAGLPESVKFHFTVSDGEHTSPEM--VLTIHLLPSDQQLPVFQVTAPRLAVSPGGS 1610
V S G+ E+ V + + P + PV Q + V+ GG
Sbjct: 985 ---------PFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPV-QTISRIFHVARGGR 1034
Query: 1611 TSVGLQ-VVVRDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNAL 1669
+ V DA++ + L R + E RP+ FT ED+ K +
Sbjct: 1035 RLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYR---FTQEDLRKRRV 1091
Query: 1670 QYIHDGSSTREDSMEISVTDGLTVTMLEVRVEVSLSEDRGPRLAAGSSLSITVASKSTAI 1729
++H G+ +++S +LEV+ + + R+A GSSL + + T
Sbjct: 1092 LFVHSGADRGWIQLQVSDGQHQATALLEVQ-----ASEPYLRVANGSSLVVPQGGQGTID 1146
Query: 1730 ITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRY 1789
HL D E+ + P +G L+R + F+ +D+ + + Y
Sbjct: 1147 TAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-------QPATAFSQQDLLDGAVLY 1199
Query: 1790 SAVFETDGHLVT-DSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITVDEGGR 1848
S +G L D+ FSV + H D + + P + I V +G
Sbjct: 1200 SH----NGSLSPRDTMAFSV-EAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEA 1254
Query: 1849 APLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASFPIQDV 1908
A + A + D + + + P G + G + D SF + V
Sbjct: 1255 AEIRRDQLEAAQEAVP-PADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAV 1313
Query: 1909 LENYIYYFQSVHESIEPTHDIFSFYVSDGTSRS--------EIHSINITIERKNDEPPR- 1959
+ Y +H E D FS V+ G E+ I +E +N P
Sbjct: 1314 DTGRVLY---LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEG 1370
Query: 1960 --MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLEN 2017
+TL P +++S + LSLQ L+ P HG + E+
Sbjct: 1371 GSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ------------HGAL--------QKED 1410
Query: 2018 GRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKI---YTELPA 2074
G S F+++ + L+ YV + D F + + +D + T LP
Sbjct: 1411 GPQARTLSAFSWRMVEEQLIRYVHDGSETLTDSFVL-MANASEMDRQSHPVAFTVTVLPV 1469
Query: 2075 SDTPH-LAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGN 2133
+D P L N GLQ+ G+ A I + L+ TD DS ++Y + E P GR+ +
Sbjct: 1470 NDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPG 1528
Query: 2134 LEQISIKGPIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISIL 2193
E +RSFTQA + G +SH GG F+F + DGE +
Sbjct: 1529 TE-------VRSFTQAQLDGGLVLFSHRGTLDGG---FRFRLSDGEHT---SPGHFFRVT 1575
Query: 2194 EDKSPPVITTNKG---LVLDENSVKKITTLQLSATDQ-DSGPTELIYRITRQPQLGHLEH 2249
K V+ + KG L + SV+ +++ L A+ + P L+YR+ R PQLG L H
Sbjct: 1576 AQKQ--VLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH 1633
Query: 2250 AA--SPGIQISSFTQADLTSRNVQYVHSSEAE---KHSDAFSFTLSDGVSE---VTQTFH 2301
A S G + +FTQA++ + N+ Y H E + D LS + T
Sbjct: 1634 AQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPARDVAATLAVA 1693
Query: 2302 ITLHPVDDSLP--VVQNLGMRVQEGMRKTITEFELKAVDADTEAES-------VTFTIVQ 2352
++ P + +N G+ V EG R IT L A + S V F + Q
Sbjct: 1694 VSFEAACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQ 1753
Query: 2353 PPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFII 2412
P G + + H F + ++ Y+H G + +D F F
Sbjct: 1754 FPSRGQLLVSEEPLHAGQPH-FLQSQLAAGQLVYAHGGGGTQQDGFHFRAH--------- 1803
Query: 2413 EEGGKEIMTAAPQP---FRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTM 2469
+G A PQ F + + V++ P+ ++ L+ + + I++ +L +
Sbjct: 1804 LQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASVPLR----LTRGSRAPISRAQLSVV 1859
Query: 2470 DPDTEDAQLVYEITTGPKHGFVENKLQPGRAAAT-FTQEDVNLGLIRYVLHKEKI 2523
DPD+ ++ YE+ P +GF+ + + G T FTQ DV+ G + +V + +
Sbjct: 1860 DPDSAPGEIEYEVQRAPHNGFL-SLVGGGLGPVTRFTQADVDSGRLAFVANGSSV 1913
Score = 152 bits (385), Expect = 5e-36
Identities = 283/1306 (21%), Positives = 503/1306 (38%), Gaps = 141/1306 (10%)
Query: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDKAGRFSWKDVNEKKVRFVHSKE 1184
L++ + E R +LF V +G+L L G + + F+ DV +K RF+H
Sbjct: 456 LDLMEAELRKSQVLFSVTRGARHGELELDIPGAQARK----MFTLLDVVNRKARFIHDGS 511
Query: 1185 KLRKGYLFLKISDQQFFSEPQ--------LINIQAFS-TQAPYVL--RNEVLHISRGERA 1233
+ L L++S P L+ IQ P+++ ++ I +
Sbjct: 512 EDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQK 571
Query: 1234 TITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAHD 1293
+ ++ D D+ + + + G ++ P P +F EL G L Y H
Sbjct: 572 PLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVERRDQPGEPATEFSCRELEAGSLVYVHR 631
Query: 1294 G---SDSTSDVA-VLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITN 1349
G D T V+ LQA+ + + + GL+L S + + + TN
Sbjct: 632 GGPAQDLTFRVSDGLQASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPANLSVETN 691
Query: 1350 RILQAEAPGASAEEIIYKITQDYPQFGEVVLLVNMPADSPADEGQHLPDGRTATPTSTFT 1409
+ Q + +++++T QFGE+ +G +G T F
Sbjct: 692 AVGQDVS-------VLFRVTGAL-QFGEL-----------QKQGAGGVEGAEWWATQAFH 732
Query: 1410 QQDINEGIVWYRHSGAPAQS-DSFRFEVSSASNAQTRLESHMFNIAILPQTPEAPKVSLE 1468
Q+D+ +G V Y + + D+ Q L + F + I Q + LE
Sbjct: 733 QRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEILSNLSFPVTI--QRATVWMLRLE 790
Query: 1469 ASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNITLPLHPNQGIIEHRDHPHSPIRYF 1528
+++ LT H + + PS ++ + P +G ++ + S + F
Sbjct: 791 PLHTQNTQQETLTT--AHLEATLEEAGPSPP-TFHYEVVQAPRKGNLQLQGTRLSDGQGF 847
Query: 1529 TQEDINQGKVMYRPPPAAPHLQELMAFSFAGLPESVKFHFTVSDGEHTSPEMVLTIHLLP 1588
TQ+DI G+V Y A E F F V+ + SP IH +
Sbjct: 848 TQDDIQAGRVTYGATARASEAVE------------DTFRFRVTAPPYFSPLYTFPIH-IG 894
Query: 1589 SDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVVRDAETAPKELFFELRRPPQHGVLLKHTA 1647
D PV +T L V GG + + V+ +A +E+ P+HG L
Sbjct: 895 GDPDAPV--LTNVLLVVPEGGEGVLSADHLFVKSLNSA--SYLYEVMERPRHGRLAWRGT 950
Query: 1648 EFRRPMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVT----DGLTVTMLEV----R 1699
+ + M T +FT ED+ + L Y HD S T ED + T + EV R
Sbjct: 951 QDKTTMVT--SFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFR 1008
Query: 1700 VEVSLSEDRGPRLAAGSSLSITVASKSTAIITRSHLAYVDDSS--PDPEIWIQLNYLPSY 1757
V + D P S VA ++T +A+ D S D ++ + L +
Sbjct: 1009 VAIQPVNDHAP--VQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL-LF 1065
Query: 1758 GTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVFETDGHLVTDSFYFSVSDMDHNHLD 1817
G+++ + E + FT ED+ +++ + H D + + D H
Sbjct: 1066 GSIVAVD----EPTRPIYRFTQEDLRKRRVLFV-------HSGADRGWIQLQVSDGQH-- 1112
Query: 1818 NQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDDDNLQRDAI-IKLSAL 1876
Q ++ A P +A + V +GG+ + + D D + ++A
Sbjct: 1113 -QATALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAG 1171
Query: 1877 PKYGCIENTGTGDRFGPETASDLEASFPIQDVLENYIYYFQSVHESIEPTHDIFSFYVSD 1936
P++G + G P TA F QD+L+ + Y S + S+ P D +F V
Sbjct: 1172 PRWGQLVRAGQ-----PATA------FSQQDLLDGAVLY--SHNGSLSP-RDTMAFSVEA 1217
Query: 1937 GTSRSEIHSINITIERKNDEPPRMTLQPLRVQLSSG--VVISNSSLSLQDLDTPDNELIF 1994
G ++ ++ +TI + P ++ ++ + G I L P +++F
Sbjct: 1218 GPVHTDA-TLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVF 1276
Query: 1995 VLTKKPDHGHVLW---RQTASEPLENGRVLVQGSTFTYQDILAGLVGYVPSVPGMVVDEF 2051
+ P G+++ A EP V +F+ + + G V Y+ S P D F
Sbjct: 1277 SVKSPPSAGYLVMVSRGALADEPPSLDPV----QSFSQEAVDTGRVLYLHSRPEAWSDAF 1332
Query: 2052 QFSLTDGLHVDTGRMKIYTE-LPAS---DTPHLAINQGLQLS-AGSVARITEQHLKVTDI 2106
+ GL + + E LPA+ + + ++ +G L+ A + R++ + +
Sbjct: 1333 SLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPT--L 1390
Query: 2107 DSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEP 2165
QV+ E P G LQ +S +F+ + + Y H G+
Sbjct: 1391 LGLSLQVL----EPPQHGALQKEDGPQARTLS------AFSWRMVEEQLIRYVHDGSETL 1440
Query: 2166 GGSFAFKFDVVDGEGNRLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSA 2224
SF + + + + +F++++L + PP++TTN GL + E + I L +
Sbjct: 1441 TDSFVLMANASEMD-RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRS 1499
Query: 2225 TDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDA 2284
TD DSG +L+Y I QP G + +PG ++ SFTQA L V + H +
Sbjct: 1500 TDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRGTLD---GG 1555
Query: 2285 FSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGMRVQEGMRKTITEFELKA-VDADTEA 2343
F F LSDG F L + + + V G + ++ L+A A T+
Sbjct: 1556 FRFRLSDGEHTSPGHFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDP 1615
Query: 2344 ESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHD 2389
+ + + +V+ P+ G + FT ++Y + Y H+
Sbjct: 1616 QLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHE 1661
>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
Length = 955
Score = 145 bits (367), Expect = 6e-34
Identities = 120/423 (28%), Positives = 162/423 (38%), Gaps = 57/423 (13%)
Query: 72 KGEVLQIAANQCCPEC--VLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQP 129
+GEV+ ++ PE + P C H +HE + W CS C C G+V C
Sbjct: 361 QGEVMGTPSSPRGPESPRLAAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVR 420
Query: 130 CPPLSCGHQELAFIP--EGSCCPVCVGLGKPCSYEGHVFQDGEDWR--LSRCAKCLCRNG 185
C +C H IP +G CCP C G C + G V +G+ + C C+C G
Sbjct: 421 C-EAACSHP----IPSRDGGCCPSCTG----CFHSGVVRAEGDVFSPPNENCTVCVCLAG 471
Query: 186 VAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWS--ENACTTCI 243
C + +C C P C C C G+ Y G +S + CTTC+
Sbjct: 472 NVSCISPECPSGPCQTP------PQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCV 525
Query: 244 CDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGS--CSYD--GVVRYQDEMWK 299
C GEV C C L C + + R GQCC C P S CS D GV ++W
Sbjct: 526 CQNGEVECSFMPCPELACPREEWRL-GPGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWS 584
Query: 300 -GSACEFCMCD-HGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEF 357
G CE C+C G V+C+ +C C I + G+CCP+C + C Y TG
Sbjct: 585 PGDPCELCICQADGSVSCKRTDCVD-SCPHP---IRIPGQCCPDC---SAGCTY--TGRI 635
Query: 358 MSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCP-PCPVGTLALEVKGQCCPDC 416
+N + + PC C C V C CP C T G+CCP C
Sbjct: 636 FYNNETFPSVL--------DPCLSCICLLGSVACSPVDCPITC---TYPFHPDGECCPVC 684
Query: 417 TSVH------CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQP 470
+ + T P CQ + C +C G C +C
Sbjct: 685 RDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALLPGDCCSSCPD 744
Query: 471 QCS 473
S
Sbjct: 745 SLS 747
Score = 138 bits (348), Expect = 1e-31
Identities = 109/409 (26%), Positives = 160/409 (39%), Gaps = 72/409 (17%)
Query: 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICK----PAVCRNPQCAFEKGEVLQIAANQC 83
C + ++ + W C C C V C+ A C +P + + G C
Sbjct: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHPIPSRDGG---------C 436
Query: 84 CPECVLRTPGSCHHEKKIHEHGTEWA--SSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
CP C C H + G ++ + C+VC C G V C CP C
Sbjct: 437 CPSCT-----GCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTP--- 488
Query: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWR--LSRCAKCLCRNGVAQCFTAQCQPLFC 199
P+ CC CV + C + G + DG + C C+C+NG +C C L C
Sbjct: 489 --PQTDCC-TCVPV--RCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELAC 543
Query: 200 NQDETVVRVPGKCCPQCS----ARSCSA--AGQVYEHGEQWSE-NACTTCICDR-GEVRC 251
++E + PG+CC C + CS G + G+ WS + C CIC G V C
Sbjct: 544 PREEWRLG-PGQCCFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSC 602
Query: 252 HKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKG--SACEFCMCD 309
+ C+ R GQCC +C + C+Y G + Y +E + C C+C
Sbjct: 603 KRTDCV----DSCPHPIRIPGQCCPDC---SAGCTYTGRIFYNNETFPSVLDPCLSCICL 655
Query: 310 HGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIP 369
G V C +C + C H DG+CCP C C YE +++
Sbjct: 656 LGSVACSPVDC-PITCTYP---FHPDGECCPVCRD----CNYEG------------RKVA 695
Query: 370 EGEKW--EDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDC 416
G+ + +D PC C C+ +V+C + C L G CC C
Sbjct: 696 NGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADPALL--PGDCCSSC 742
Score = 90.1 bits (222), Expect = 4e-17
Identities = 98/398 (24%), Positives = 135/398 (33%), Gaps = 112/398 (28%)
Query: 221 CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVS 280
C G ++E +W+E C+ C C+ G+V C K C R G CC C
Sbjct: 386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRC---EAACSHPIPSRDGGCCPSCT- 441
Query: 281 PAGSCSYDGVVRYQDEMWK--GSACEFCMCDHGQVTCQTGECAKVECA------------ 326
C + GVVR + +++ C C+C G V+C + EC C
Sbjct: 442 ---GCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSCISPECPSGPCQTPPQTDCCTCVP 498
Query: 327 ----------RDEELIHLDGKCCPECISRNG------------YCVYEE----------- 353
D + G C C+ +NG C EE
Sbjct: 499 VRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFT 558
Query: 354 -------TGEFMSSNASEVKRIPEGEKWEDG-PCKVCECRG-AQVTCYEPSC-PPCPVGT 403
TG + N E P G+ W G PC++C C+ V+C C CP
Sbjct: 559 CQEPTPSTGCSLDDNGVE---FPIGQIWSPGDPCELCICQADGSVSCKRTDCVDSCP--- 612
Query: 404 LALEVKGQCCPDCTSVHCHPDCLTCSQS--PDHCDLCQDPTKLLQNGWCVHSCGLGFYQA 461
+ + GQCCPDC++ + + + P D C SC
Sbjct: 613 HPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCL-------------SC------- 652
Query: 462 GSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSC-----AVCHES 516
+CL CS + C+ P G+C P C D Y+ R + E
Sbjct: 653 --ICLLGSVACSPVDCPITCTYPFHP----DGECCPVCRDCNYEGRKVANGQVFTLDDEP 706
Query: 517 CAGCWGPT-EKHC------LACRDPLHVLRDGGCESSC 547
C C E C AC DP L G C SSC
Sbjct: 707 CTRCTCQLGEVSCEKVPCQRACADP--ALLPGDCCSSC 742
Score = 51.2 bits (121), Expect = 2e-05
Identities = 97/438 (22%), Positives = 126/438 (28%), Gaps = 134/438 (30%)
Query: 517 CAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSC----------D 566
C+ CW C D CE++C +R G C C D
Sbjct: 404 CSQCW---------CEDGKVTCEKVRCEAACSHPIPSRDGGCCPSCTGCFHSGVVRAEGD 454
Query: 567 SCGPSSPRCLTCTEKTVLHDGKCMS-ECPGGYYADATGRCKVCHNSCASCSGPTPSHCTA 625
P + C C + + C+S ECP G C P + C
Sbjct: 455 VFSPPNENCTVCV--CLAGNVSCISPECPSG-----------------PCQTPPQTDCCT 495
Query: 626 CSPPKALRQGHCLPRCGEGFYSDHGVCKAC----------------------------HS 657
C P + G G F C C
Sbjct: 496 CVPVRCYFHGRWYAD-GAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQ 554
Query: 658 SCLACMGPAPSHCTGCKKPEEGLQ--VEQLSDVGIPSGECLAQCRAHFYLESTGICEACH 715
C C P PS TGC + G++ + Q+ G P C+ Q
Sbjct: 555 CCFTCQEPTPS--TGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSV------------ 600
Query: 716 QSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDG------YFHQEGSCTECHPTCRQCH 769
SC R +C D P + + GQC C G F+ + C C
Sbjct: 601 -SCKRT------DCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCI 653
Query: 770 GPLES------DC-ISC-YPHISLTNGNCRTSCRE-----EQFLNLVGYCADCHHLCQHC 816
L S DC I+C YP +G C CR+ + N + D C C
Sbjct: 654 CLLGSVACSPVDCPITCTYPF--HPDGECCPVCRDCNYEGRKVANGQVFTLD-DEPCTRC 710
Query: 817 AADLHNTGSICLRCQNA---HYLLLGDHC--VPD-----------CPSGYYAERGACKKC 860
L + CQ A LL GD C PD P G A A +
Sbjct: 711 TCQLGEVSCEKVPCQRACADPALLPGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSL 770
Query: 861 HSSCRTCQGRGPFSCSSC 878
H P +CSSC
Sbjct: 771 HGDT-----EAPVNCSSC 783
Score = 42.7 bits (99), Expect = 0.007
Identities = 109/472 (23%), Positives = 158/472 (33%), Gaps = 130/472 (27%)
Query: 569 GPSSPRCLT----CTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHC- 623
GP SPR C +H+ + PG +C C + +C C
Sbjct: 373 GPESPRLAAGPSPCWHLGAMHESRSRWTEPG------CSQCW-CEDGKVTCE---KVRCE 422
Query: 624 TACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVE 683
ACS P R G C P C F+S GV +A P +CT C V
Sbjct: 423 AACSHPIPSRDGGCCPSCTGCFHS--GVVRAEGD----VFSPPNENCTVC--------VC 468
Query: 684 QLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQC 743
+V S EC +G C+ Q+ +C C P G+
Sbjct: 469 LAGNVSCISPEC-----------PSGPCQTPPQT----------DCCTCVPVRCYFHGRW 507
Query: 744 LSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHIS-------LTNGNCRTSCRE 796
+ DG G EC TC +G +E + C P ++ L G C +C+E
Sbjct: 508 YA---DGAVFSGGG-DEC-TTCVCQNGEVECSFMPC-PELACPREEWRLGPGQCCFTCQE 561
Query: 797 --------------EQFLNLVGYCADCHHLCQHCAADLHNTGSI-CLR--CQNA--HYLL 837
E + + D LC C AD GS+ C R C ++ H +
Sbjct: 562 PTPSTGCSLDDNGVEFPIGQIWSPGDPCELC-ICQAD----GSVSCKRTDCVDSCPHPIR 616
Query: 838 LGDHCVPDCPSG------YYAERGACKKCHSSCRTCQG-RGPFSCSSCDTNLVLSH---- 886
+ C PDC +G + C +C G +CS D + ++
Sbjct: 617 IPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDCPITCTYPFHP 676
Query: 887 TGTCSTTCFPGHYLD-----------DNHVCQPCNTHCG--SCDSQASCTSCRDPNKVLL 933
G C C +Y D+ C C G SC+ +C DP LL
Sbjct: 677 DGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP--ALL 734
Query: 934 FGEC------------QYESCAPQYYLDF-----STNTCKECDWSCSACSGP 968
G+C + + +P + F S + E +CS+C GP
Sbjct: 735 PGDCCSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGP 786
Score = 32.7 bits (73), Expect = 7.5
Identities = 55/247 (22%), Positives = 81/247 (32%), Gaps = 83/247 (33%)
Query: 894 CFPGHY--LDDNHVCQP-CNTHCGS--CDSQASCTSCRDPNKVLLFGECQYESCAP--QY 946
C PG + H P C+ CGS C + C SC+D + G E+ P +Y
Sbjct: 53 CCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVC-SCQDGEQ----GATCPETHGPCGEY 107
Query: 947 YLDFSTNT--CKECDWSCSACSGPLKTDC-LQCMDGYVLQDGACVEQCLSSFYQDSGLCK 1003
D + N C+E C +T ++C D +++C++S
Sbjct: 108 GCDLTCNHGGCQEVARVCPVGFSMTETAVGIRCTD---------IDECVTS--------S 150
Query: 1004 CDSYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKC--------TACPQGC 1055
C+ +C+ +G C ECG G +H C T C Q C
Sbjct: 151 CEGHCVNTEGGFVC----------------ECGPGMQLSADRHSCQDTDECLGTPCQQRC 194
Query: 1056 ------LQCSHRDRCHL---------------------CDHGFFLKSGLCVYNCVPGFSV 1088
+CS R HL C H G + C PGF +
Sbjct: 195 KNSIGSYKCSCRTGFHLHGNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRL 254
Query: 1089 HTSNETC 1095
+C
Sbjct: 255 RADRVSC 261
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 145 bits (366), Expect = 8e-34
Identities = 145/578 (25%), Positives = 202/578 (34%), Gaps = 100/578 (17%)
Query: 27 ACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPE 86
ACV+ + D +++ D+C+ CRC G + IC A C C E + +CCP
Sbjct: 335 ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINC-----ERYYVPEGECCPV 389
Query: 87 C-----VLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
C P C+ I HG W C+ C C +GE C C ++
Sbjct: 390 CEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKV- 448
Query: 142 FIPEGSCCPVC------------VGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQC 189
G CCPVC G C+ G +G + C C C N C
Sbjct: 449 ---PGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELC 505
Query: 190 ------FTAQCQPLF------CNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSEN 237
T C F C E R P KC P + C +HG
Sbjct: 506 SERKQGCTLNCPFGFLTDAQNCEICECRPR-PKKCRPIICDKYCPLGLLKNKHG------ 558
Query: 238 ACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHG----QCCEECVSP-----AGSC-SY 287
C C C +C + +C + C G + HG +C E S +G+C +
Sbjct: 559 -CDICRCK----KCPELSCSKI-CPLG-FQQDSHGCLICKCREASASAGPPILSGTCLTV 611
Query: 288 DGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNG 347
DG +E W C C C +G+ C C C IH G+CCP C +
Sbjct: 612 DGHHHKNEESWH-DGCRECYCLNGREMCALITCPVPACG--NPTIH-PGQCCPSC--ADD 665
Query: 348 YCVYE-ETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLAL 406
+ V + E +A + EGE W C C C +V C CPP +
Sbjct: 666 FVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPS- 724
Query: 407 EVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCL 466
+ CCP CT P + P++C + L W C + C+
Sbjct: 725 RTQDSCCPQCTDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVC--------TSCI 776
Query: 467 ACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCH------------ 514
S + SC+ P+L R GQC P C + + VCH
Sbjct: 777 CIDSVISCFSESCPSVSCERPVL-RKGQCCPYCIEDTIPKK---VVCHFSGKAYADEERW 832
Query: 515 --ESCAGCW---GPTEKHCLACRDPLHVLRDGGCESSC 547
+SC C+ G T ++C PL + E SC
Sbjct: 833 DLDSCTHCYCLQGQTLCSTVSC-PPLPCVEPINVEGSC 869
Score = 145 bits (365), Expect = 1e-33
Identities = 123/514 (23%), Positives = 178/514 (34%), Gaps = 122/514 (23%)
Query: 9 GLALALAEFAVLPHHSEGACVYQDSLLADATIWKPDSCQSCRC-----HGDIVICKPAVC 63
G + E V P ++ C +LA W+ D C C+C H +C C
Sbjct: 384 GECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVC-GQTC 442
Query: 64 RNP-----QC--AFEKGEVLQIAANQC-----------------------CPEC-VLRTP 92
NP +C E+ ++ + C C C + T
Sbjct: 443 TNPVKVPGECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTE 502
Query: 93 GSCHHEKK----IHEHGTEWASSPCSVCSCNHGEVRCTP--------------------- 127
C K+ G + C +C C +C P
Sbjct: 503 ELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDIC 562
Query: 128 --QPCPPLSCGH-QELAFIPEGSCCPVC------VGLGKP------CSYEGHVFQDGEDW 172
+ CP LSC L F + C +C G P + +GH ++ E W
Sbjct: 563 RCKKCPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESW 622
Query: 173 RLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQC------------SARS 220
C +C C NG C C C PG+CCP C +
Sbjct: 623 H-DGCRECYCLNGREMCALITCPVPACGNPTI---HPGQCCPSCADDFVVQKPELSTPSI 678
Query: 221 CSA-AGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECV 279
C A G+ + GE W+ ++CT C C G V C + C PL C Q+ +R CC +C
Sbjct: 679 CHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC---QNPSRTQDSCCPQCT 735
Query: 280 ------------SPAGSCSYD-GVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECA 326
S C D G + E WK C C+C ++C + C V C
Sbjct: 736 DQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCE 795
Query: 327 RDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRG 386
R + G+CCP YC+ + + + + S K + E+W+ C C C
Sbjct: 796 RP---VLRKGQCCP-------YCIEDTIPKKVVCHFSG-KAYADEERWDLDSCTHCYCLQ 844
Query: 387 AQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVH 420
Q C SCPP P + V+G CCP C ++
Sbjct: 845 GQTLCSTVSCPPLPC-VEPINVEGSCCPMCPEMY 877
Score = 116 bits (291), Expect = 4e-25
Identities = 151/612 (24%), Positives = 213/612 (34%), Gaps = 170/612 (27%)
Query: 146 GSCCPV--CVGLGKP-CSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQD 202
G CC V CV KP C + + DG+ +R+ C C C+ GVA CFTAQC + C +
Sbjct: 320 GKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCER- 378
Query: 203 ETVVRVP-GKCCPQC--------SARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHK 253
VP G+CCP C + C A G + HG++W E+ CT C C GE
Sbjct: 379 ---YYVPEGECCPVCEDPVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGE----- 430
Query: 254 QACLPLRCGKG-QSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSAC-EFCMCDHG 311
+ C+ CG+ + + G+CC C P ++ AC E C
Sbjct: 431 RHCVATVCGQTCTNPVKVPGECCPVCEEPT-------IITVDP-----PACGELSNCTLT 478
Query: 312 QVTCQTG------ECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEV 365
C G C +C EEL C R C
Sbjct: 479 GKDCINGFKRDHNGCRTCQCINTEEL----------CSERKQGCTL-------------- 514
Query: 366 KRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPP-CPVGTLALEVKGQC----CPDCTSVH 420
P G + C++CECR C C CP+G L+ K C C C +
Sbjct: 515 -NCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLG--LLKNKHGCDICRCKKCPELS 571
Query: 421 CHPDCLTCSQSPDH-CDLCQ------DPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCS 473
C C Q H C +C+ + +G C+ G S C+ +C
Sbjct: 572 CSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHDGCR-EC- 629
Query: 474 TCTSGLE-CS--SCQPPL----LMRHGQCVPTCGDGFYQDR---HSCAVCH--------- 514
C +G E C+ +C P + GQC P+C D F + + ++CH
Sbjct: 630 YCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVE 689
Query: 515 ------ESCAGCWGPTEKHC--------LACRDPLHVLRDGGCESSCGKGF--------- 551
+SC C + + L C++P +D C + F
Sbjct: 690 GETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRT-QDSCCPQCTDQPFRPSLSRNNS 748
Query: 552 -----YNRQG--------------TCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSE 592
N +G T C S SC S ++C E+ VL G+C
Sbjct: 749 VPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSC-ERPVLRKGQCCPY 807
Query: 593 CPGGYYADATGRCKVCH--------------NSCASC---SGPTPSHCTACSPPKALR-- 633
C D + VCH +SC C G T +C P +
Sbjct: 808 C----IEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPI 863
Query: 634 --QGHCLPRCGE 643
+G C P C E
Sbjct: 864 NVEGSCCPMCPE 875
Score = 104 bits (259), Expect = 2e-21
Identities = 162/737 (21%), Positives = 238/737 (32%), Gaps = 189/737 (25%)
Query: 189 CFTAQCQPLF---CNQDETVVR---VPGKCCPQCSARSCSAAGQVYEHGEQWSENA---- 238
C A+C+ F C +D ++ PG+CCP S C+ AG + + + + N
Sbjct: 174 CSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSK 233
Query: 239 ---------------------CTTCICD------------RGEVRCHKQAC--LPLRC-- 261
C T C +VR C LP RC
Sbjct: 234 ASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCEC 293
Query: 262 ------------GKGQSRARR----HGQCCE--ECVSPA-GSCSYDGVVRYQDEMWKGSA 302
G R G+CC+ ECV+ +C ++ V Y +M++
Sbjct: 294 LSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDN 353
Query: 303 CEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNA 362
C FC C G C T +C ++ C E +G+CCP C Y G + +
Sbjct: 354 CRFCRCQGGVAICFTAQCGEINC---ERYYVPEGECCPVC-EDPVYPFNNPAGCYANGLI 409
Query: 363 SEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCH 422
+ G++W + C C+C + C C T ++V G+CCP C
Sbjct: 410 -----LAHGDRWREDDCTFCQCVNGERHCVATVCG--QTCTNPVKVPGECCPVCE----E 458
Query: 423 PDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECS 482
P +T P C + T L C++ GF + + C CQ C
Sbjct: 459 PTIITV--DPPACGELSNCT--LTGKDCIN----GFKRDHNGCRTCQ-----------CI 499
Query: 483 SCQPPLLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGG 542
+ + R C C GF D +C +C CR R
Sbjct: 500 NTEELCSERKQGCTLNCPFGFLTDAQNCEICE----------------CRPRPKKCRPII 543
Query: 543 CESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADAT 602
C+ C G + C C RC C E + C CP G+ D+
Sbjct: 544 CDKYCPLGLLKNKHGCDIC------------RCKKCPELS------CSKICPLGFQQDSH 585
Query: 603 GRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD---HGVCKACH--- 656
G C +C AS S P + G CL G ++ H C+ C+
Sbjct: 586 G-CLICKCREASASAGPP-----------ILSGTCLTVDGHHHKNEESWHDGCRECYCLN 633
Query: 657 ----SSCLACMGPA-------PSHCTGCKKPEEGLQVEQLSDVGI---PSGECLAQCRAH 702
+ + C PA P C + +Q +LS I P GE +
Sbjct: 634 GREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGET- 692
Query: 703 FYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECH 762
+ ++S C CH C + PS C QC D F S
Sbjct: 693 WNIDSCTQC-TCHSGRVLCETEVCPPLLCQNPSRT--QDSCCPQCTDQPFRPSLSRNNSV 749
Query: 763 PT-CRQCHGPLE-----------SDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCH 810
P C+ G + + CI IS + +C + E L G C
Sbjct: 750 PNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPVLR-KGQC---- 804
Query: 811 HLCQHCAADLHNTGSIC 827
C +C D +C
Sbjct: 805 --CPYCIEDTIPKKVVC 819
Score = 56.6 bits (135), Expect = 5e-07
Identities = 195/974 (20%), Positives = 283/974 (29%), Gaps = 253/974 (25%)
Query: 181 LCRNGVAQCFTAQCQPLFCNQDE----TVVRVPGKCCPQCSAR---SCSAAGQVYEHGEQ 233
L R+G C C + ++V+ CC C+++ SC +Y
Sbjct: 27 LARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYG---- 82
Query: 234 WSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEE---------------- 277
CDRG +RC + L G S CE+
Sbjct: 83 ---------TCDRG-LRCVIRPPL-----NGDSLTEYEAGVCEDENWTDDQLLGFKPCNE 127
Query: 278 -----CVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECA------ 326
C G C + +R ++ + + C+ ++ + +C+K C
Sbjct: 128 NLIAGCNIINGKCECN-TIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCEVQFSPR 186
Query: 327 --RDEELIH---LDGKCCP---ECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGP 378
D LI G+CCP C+ C+ + N + + G+ E
Sbjct: 187 CPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVC---QPGNLNILVSKASGKPGEC-- 241
Query: 379 CKVCECRGA-QVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDL 437
C + EC+ V C CPP + C PD C P C+
Sbjct: 242 CDLYECKPVFGVDCRTVECPPVQ--------QTACPPDSYETQVRLTADGCCTLPTRCE- 292
Query: 438 CQDPTKLLQNGWCVHS-CGLGFYQAGSLCLACQPQCST---CTSGLEC-SSCQPPLLMRH 492
C+ CG + GS T C EC + +P + +
Sbjct: 293 ------------CLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNN 340
Query: 493 GQCVPTCGDGFYQDRHSCAVCHESCAGCWG-------------PTEKHCLACRDPLHVLR 539
+ GD F D C A C+ P + C C DP++
Sbjct: 341 VEYYD--GDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCEDPVYPFN 398
Query: 540 D-GGCESS---CGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPG 595
+ GC ++ G R+ C+ C C C+ C C
Sbjct: 399 NPAGCYANGLILAHGDRWREDDCTFCQ-----CVNGERHCVATV---------CGQTC-- 442
Query: 596 GYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCL---PRCGEGFYSDHGVC 652
T KV C C PT PP +C C GF DH C
Sbjct: 443 ------TNPVKVPGECCPVCEEPT---IITVDPPACGELSNCTLTGKDCINGFKRDHNGC 493
Query: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTG--I 710
+ C C+ C + ++G C C F ++ I
Sbjct: 494 RTCQ-----CINTEEL----CSERKQG---------------CTLNCPFGFLTDAQNCEI 529
Query: 711 CEA-----------CHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCT 759
CE C + C K+ H C C + C CP G+ C
Sbjct: 530 CECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKKCP-ELSCSKICPLGFQQDSHGCL 588
Query: 760 ECHPTCRQCH---GP--LESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQ 814
C CR+ GP L C++ H + CRE LN CA
Sbjct: 589 ICK--CREASASAGPPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVP 646
Query: 815 HCAADLHNTGSICLRCQNAHYLLLGDHCVPD---CPSGYYAERGACKKCHSSCRTCQGRG 871
C + G C C + + + P P G Y G S
Sbjct: 647 ACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDS--------- 697
Query: 872 PFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRD-PNK 930
C+ C TC G L + VC P S + C C D P +
Sbjct: 698 ---CTQC--------------TCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFR 740
Query: 931 VLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTD-CLQCMDGYVLQDGACVE 989
L + P Y CK + + K D C C+ C++
Sbjct: 741 PSL----SRNNSVPNY--------CKNDEGDIFLAAESWKPDVCTSCI---------CID 779
Query: 990 QCLSSFYQDSGLCKCDSYCL---QCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAK- 1045
+S F + C+ L QC C C + + C GK Y AD +
Sbjct: 780 SVISCFSESCPSVSCERPVLRKGQC-----CPYCIEDTIPKKVVC-HFSGKAY-ADEERW 832
Query: 1046 --HKCTACPQGCLQ 1057
CT C CLQ
Sbjct: 833 DLDSCTHC--YCLQ 844
>gi|20336246 proprotein convertase subtilisin/kexin type 5
preproprotein [Homo sapiens]
Length = 913
Score = 139 bits (350), Expect = 6e-32
Identities = 86/244 (35%), Positives = 111/244 (45%), Gaps = 26/244 (10%)
Query: 410 GQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGW--CVHSCGLGFYQAGSL-CL 466
G C P+C+ V C PDHC+ C L+N CV SC G Y A C
Sbjct: 634 GPCDPECSEVGCD------GPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCR 687
Query: 467 ACQPQCSTC--TSGLECSSCQPPLLMRH--GQCVPTCGDGFYQD--RHSCAVCHESCAGC 520
C P C +C + G +C SC+ + CV C DG YQD ++ C C E+C C
Sbjct: 688 KCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTC 747
Query: 521 WGPTEKH-CLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSC-GPSSPRCLTC 578
TE H C CRD L L+ C SC G Y C C + C +C G + C+ C
Sbjct: 748 ---TEFHNCTECRDGLS-LQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINC 803
Query: 579 TEKTVLHDGKCMSECPGGYYADATGR-----CKVCHNSCASCSGPTPSHCTACSPPKALR 633
TE + DG+C+ C YY D + CK C SC +C+GP +CT+C L
Sbjct: 804 TEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLD 863
Query: 634 QGHC 637
G C
Sbjct: 864 LGMC 867
Score = 129 bits (325), Expect = 4e-29
Identities = 78/241 (32%), Positives = 108/241 (44%), Gaps = 19/241 (7%)
Query: 805 YCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDH--CVPDCPSGYY-AERGACKKCH 861
Y C C D C C + +Y L + CV CP G+Y A++ C+KC
Sbjct: 632 YAGPCDPECSEVGCDGPGPDH-CNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCA 690
Query: 862 SSCRTCQGRGPFSCSSCDTNLVLSH-TGTCSTTCFPGHYLDDN-HVCQPCNTHCGSCDSQ 919
+C +C G C SC L+ T +C T C G Y D ++C+ C+ +C +C
Sbjct: 691 PNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEF 750
Query: 920 ASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDG 979
+CT CRD + L G SC Y F+ C+ C C+ C+G C+ C +G
Sbjct: 751 HNCTECRDG--LSLQGSRCSVSCEDGRY--FNGQDCQPCHRFCATCAGAGADGCINCTEG 806
Query: 980 YVLQDGACVEQCLSSFYQD-------SGLCKCDSYCLQCQGP--HECTRCKGPFLLLEAQ 1030
Y ++DG CV+ C S+Y D KCD CL C GP CT C +LL
Sbjct: 807 YFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPSGYLLDLGM 866
Query: 1031 C 1031
C
Sbjct: 867 C 867
Score = 104 bits (259), Expect = 2e-21
Identities = 81/282 (28%), Positives = 110/282 (39%), Gaps = 37/282 (13%)
Query: 351 YEETGEFMSSNASEVKRIPE-----GEKWEDGPCKVCECRGAQVTCYEPS---CPPCPVG 402
Y T EF R+ + G + GPC EC ++V C P C C
Sbjct: 603 YSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDP-EC--SEVGCDGPGPDHCNDCLHY 659
Query: 403 TLALEVKGQCC-PDCTSVHCHPDCLTCSQSPDHCDLC----QDPTKLLQNGW-------- 449
L+ + C C H H D C + +C+ C D + G+
Sbjct: 660 YYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNS 719
Query: 450 CVHSCGLGFYQ--AGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR 507
CV C G YQ +LC C C TCT C+ C+ L ++ +C +C DG Y +
Sbjct: 720 CVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDGRYFNG 779
Query: 508 HSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFY------NRQGTCSAC 561
C CH CA C G C+ C + + + DG C SC +Y N +C C
Sbjct: 780 QDCQPCHRFCATCAGAGADGCINCTEG-YFMEDGRCVQSCSISYYFDHSSENGYKSCKKC 838
Query: 562 DQSCDSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYYADAT 602
D SC +C GP C +C +L G C G DAT
Sbjct: 839 DISCLTCNGPGFKNCTSCPSGYLLDLGMCQM---GAICKDAT 877
Score = 99.4 bits (246), Expect = 6e-20
Identities = 78/304 (25%), Positives = 109/304 (35%), Gaps = 40/304 (13%)
Query: 608 CHNSCAS--CSGPTPSHCTACSPPKALRQGH---CLPRCGEGFY-SDHGVCKACHSSCLA 661
C C+ C GP P HC C + + C+ C G Y +D C+ C +C +
Sbjct: 636 CDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCES 695
Query: 662 CMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLEST-GICEACHQSCFR 720
C G C CK G + + + C+ C Y ++ +C C ++C
Sbjct: 696 CFGSHGDQCMSCKY---GYFLNE------ETNSCVTHCPDGSYQDTKKNLCRKCSENCKT 746
Query: 721 CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCY 780
C HNCT+C L +C C DG + C CH C C G CI+C
Sbjct: 747 CT--EFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCT 804
Query: 781 PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD 840
+ +G C SC + Y D H ++ CL C +
Sbjct: 805 EGYFMEDGRCVQSCS-------ISYYFD--HSSENGYKSCKKCDISCLTCNGPGF----K 851
Query: 841 HCVPDCPSGYYAERGACKK---CHSSCRTCQGRGPFSCSSCDTNL----VLSHTGTCSTT 893
+C CPSGY + G C+ C + G F NL VL C T
Sbjct: 852 NCT-SCPSGYLLDLGMCQMGAICKDATEESWAEGGFCMLVKKNNLCQRKVLQQL-CCKTC 909
Query: 894 CFPG 897
F G
Sbjct: 910 TFQG 913
Score = 87.4 bits (215), Expect = 3e-16
Identities = 56/201 (27%), Positives = 81/201 (40%), Gaps = 22/201 (10%)
Query: 912 HCGSCDSQASCTSCRDPN------------KVLLFGECQYESCAPQYYLDFSTNTCKECD 959
+ G CD + S C P K+ SC P +Y C++C
Sbjct: 632 YAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGHY-HADKKRCRKCA 690
Query: 960 WSCSACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDS--GLC-KCDSYCLQCQGP 1014
+C +C G C+ C GY L + +CV C YQD+ LC KC C C
Sbjct: 691 PNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEF 750
Query: 1015 HECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHLCDHGFF 1072
H CT C+ L ++C C G + + C C + C C + D C C G+F
Sbjct: 751 HNCTECRDGLSLQGSRCSVSCEDGRYFN--GQDCQPCHRFCATCAGAGADGCINCTEGYF 808
Query: 1073 LKSGLCVYNCVPGFSVHTSNE 1093
++ G CV +C + S+E
Sbjct: 809 MEDGRCVQSCSISYYFDHSSE 829
Score = 49.3 bits (116), Expect = 8e-05
Identities = 70/309 (22%), Positives = 101/309 (32%), Gaps = 98/309 (31%)
Query: 210 GKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRAR 269
G C P+CS C G + C C+ +++ + + C+ C G A
Sbjct: 634 GPCDPECSEVGCDGPG----------PDHCNDCLHYYYKLKNNTRICVS-SCPPGHYHAD 682
Query: 270 RHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDE 329
+ + C +C CE C HG
Sbjct: 683 K--KRCRKC---------------------APNCESCFGSHGDQ---------------- 703
Query: 330 ELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVC-ECRGAQ 388
C C + GY + EET S V P+G ++D +C +C
Sbjct: 704 ---------CMSC--KYGYFLNEETN-------SCVTHCPDG-SYQDTKKNLCRKCSENC 744
Query: 389 VTCYE-PSCPPCPVGTLALEVKGQCC------------PDCTSVHCHPDCLTCS-QSPDH 434
TC E +C C G L ++G C DC CH C TC+ D
Sbjct: 745 KTCTEFHNCTECRDG---LSLQGSRCSVSCEDGRYFNGQDCQP--CHRFCATCAGAGADG 799
Query: 435 CDLCQDPTKLLQNGWCVHSCGLGFY------QAGSLCLACQPQCSTCTSG--LECSSCQP 486
C C + +++G CV SC + +Y C C C TC C+SC
Sbjct: 800 CINCTE-GYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPS 858
Query: 487 PLLMRHGQC 495
L+ G C
Sbjct: 859 GYLLDLGMC 867
>gi|37693519 BMP-binding endothelial regulator precursor protein
[Homo sapiens]
Length = 685
Score = 138 bits (348), Expect = 1e-31
Identities = 92/324 (28%), Positives = 132/324 (40%), Gaps = 46/324 (14%)
Query: 46 CQSCRCHGDIVICKPAVCR--NPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHE 103
C C C V CK C + CA + Q A CC +C C +E +
Sbjct: 67 CIMCVCLNKEVTCKREKCPVLSRDCALA---IKQRGA--CCEQCK-----GCTYEGNTYN 116
Query: 104 HGTEWAS--SPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSY 161
+W S PC + C G V + C H + G CCP C G C +
Sbjct: 117 SSFKWQSPAEPCVLRQCQEGVVTESGVRCVV----HCKNPLEHLGMCCPTCPG----CVF 168
Query: 162 EGHVFQDGEDWRL--SRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSAR 219
EG +Q+GE+++ S+C KC C G QC C L C Q + + PG+CCP+C +
Sbjct: 169 EGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIP-PGQCCPKCLGQ 227
Query: 220 ---------SCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARR 270
SC VY++G + + CT C C V C ++ P C +GQ
Sbjct: 228 RKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQEG--- 284
Query: 271 HGQCCEECV-----SPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVEC 325
CCEEC+ C + + EMW C C C G+ C+ +C +
Sbjct: 285 ---CCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISS 341
Query: 326 ARDEELIHLDGKCCPECISRNGYC 349
++++ G CCP C + G C
Sbjct: 342 CPQGKILNRKG-CCPICTEKPGVC 364
Score = 125 bits (314), Expect = 8e-28
Identities = 96/323 (29%), Positives = 129/323 (39%), Gaps = 45/323 (13%)
Query: 111 SPCSVCSCNHGEVRCTPQPCPPLS--CGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQD 168
+PC +C C + EV C + CP LS C LA G+CC C G C+YEG+ +
Sbjct: 65 NPCIMCVCLNKEVTCKREKCPVLSRDCA---LAIKQRGACCEQCKG----CTYEGNTYNS 117
Query: 169 GEDWR--LSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQ 226
W+ C C+ GV +C N E + G CCP C C G
Sbjct: 118 SFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHL----GMCCPTCP--GCVFEGV 171
Query: 227 VYEHGEQWSE--NACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVS---- 280
Y+ GE++ + CT C C G +C ++ C L C + S GQCC +C+
Sbjct: 172 QYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHI-PPGQCCPKCLGQRKV 230
Query: 281 ---PAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGK 337
P GSC + V + C C C V C+ C + +E
Sbjct: 231 FDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPGGCDQGQE------G 284
Query: 338 CCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCP 397
CC EC+ R E+ N K +GE W C +C C + C C
Sbjct: 285 CCEECLLR---VPPEDIKVCKFGN----KIFQDGEMWSSINCTICACVKGRTECRNKQCI 337
Query: 398 P---CPVGTLALEVKGQCCPDCT 417
P CP G + L KG CCP CT
Sbjct: 338 PISSCPQGKI-LNRKG-CCPICT 358
Score = 125 bits (313), Expect = 1e-27
Identities = 71/228 (31%), Positives = 99/228 (43%), Gaps = 31/228 (13%)
Query: 83 CCPECVLRTPGSCHHEKKIHEHGTEWA--SSPCSVCSCNHGEVRCTPQPCPPLSCGHQEL 140
CCP C PG C E ++ G E+ S C+ CSC G +C + CP LSC Q L
Sbjct: 159 CCPTC----PG-CVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCP-QHL 212
Query: 141 AFIPEGSCCPVCVGLGK-------PCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQ 193
+ IP G CCP C+G K C + V+ +G + C C CR+ C
Sbjct: 213 SHIPPGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKC 272
Query: 194 CQPLFCNQDETVVRVPGKCCPQCSARS-------CSAAGQVYEHGEQWSENACTTCICDR 246
P C+Q + CC +C R C ++++ GE WS CT C C +
Sbjct: 273 SHPGGCDQGQE------GCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVK 326
Query: 247 GEVRCHKQACLPL-RCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRY 293
G C + C+P+ C +G+ R+ CC C G C+ G Y
Sbjct: 327 GRTECRNKQCIPISSCPQGKILNRK--GCCPICTEKPGVCTVFGDPHY 372
Score = 89.0 bits (219), Expect = 9e-17
Identities = 102/379 (26%), Positives = 139/379 (36%), Gaps = 79/379 (20%)
Query: 235 SENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQ 294
++N C C+C EV C ++ C P+ ++ G CCE+C C+Y+G
Sbjct: 63 TDNPCIMCVCLNKEVTCKREKC-PVLSRDCALAIKQRGACCEQC----KGCTYEGNTYNS 117
Query: 295 DEMWKGSA--CEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCV-- 350
W+ A C C G VT ++G V C E HL G CCP C CV
Sbjct: 118 SFKWQSPAEPCVLRQCQEGVVT-ESGVRCVVHCKNPLE--HL-GMCCPTCPG----CVFE 169
Query: 351 ---YEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCP--PCPVGTLA 405
Y+E EF PEG K C C C G + C CP CP L+
Sbjct: 170 GVQYQEGEEFQ----------PEGSK-----CTKCSCTGGRTQCVREVCPILSCP-QHLS 213
Query: 406 LEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLC 465
GQCCP C D L D+ + + L + +C
Sbjct: 214 HIPPGQCCPKCLGQRKVFD-LPFGSCLFRSDVYDNGSSFLYDNCTACTC-------RDST 265
Query: 466 LACQPQCS---TCTSGLECSSCQPPLLMRHGQCVPTC--GDGFYQDRH-----SCAVCHE 515
+ C+ +CS C G E C+ LL + + C G+ +QD +C +
Sbjct: 266 VVCKRKCSHPGGCDQGQE-GCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTI--- 321
Query: 516 SCAGCWGPTE---KHCLACRDPLHVLRDGGCESSCGKG-FYNRQGTCSACDQSCDSCGP- 570
CA G TE K C+ SSC +G NR+G C C + C
Sbjct: 322 -CACVKGRTECRNKQCIPI-------------SSCPQGKILNRKGCCPICTEKPGVCTVF 367
Query: 571 SSPRCLTCTEKTVLHDGKC 589
P T +T G C
Sbjct: 368 GDPHYNTFDGRTFNFQGTC 386
Score = 76.3 bits (186), Expect = 6e-13
Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 13/142 (9%)
Query: 26 GACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCP 85
G+C+++ + + + + D+C +C C V+CK C +P ++G+ CC
Sbjct: 236 GSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCK-RKCSHPG-GCDQGQ------EGCCE 287
Query: 86 ECVLRTPGS----CHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
EC+LR P C KI + G W+S C++C+C G C + C P+S Q
Sbjct: 288 ECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKI 347
Query: 142 FIPEGSCCPVCVGLGKPCSYEG 163
+G CCP+C C+ G
Sbjct: 348 LNRKG-CCPICTEKPGVCTVFG 368
Score = 53.9 bits (128), Expect = 3e-06
Identities = 81/343 (23%), Positives = 110/343 (32%), Gaps = 81/343 (23%)
Query: 361 NASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVG-TLALEVKGQCCPDCTSV 419
N EV +IP D PC +C C +VTC CP LA++ +G CC C
Sbjct: 52 NEGEVLQIPF---ITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCEQCKGC 108
Query: 420 HCHPDCLTCS---QSP-DHCDL--CQDPTKLLQNGWCVHSCGLGFYQAGSLCLAC----- 468
+ S QSP + C L CQ+ CV C G C C
Sbjct: 109 TYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCCPTCPGCVF 168
Query: 469 -----------QPQCS-----TCTSGLE------CSSCQPPLLMRH---GQCVPTC---- 499
QP+ S +CT G C P + H GQC P C
Sbjct: 169 EGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPGQCCPKCLGQR 228
Query: 500 -------GDGFYQD---RHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGK 549
G ++ + + +++C C CRD V C+ C
Sbjct: 229 KVFDLPFGSCLFRSDVYDNGSSFLYDNCTAC---------TCRDSTVV-----CKRKCSH 274
Query: 550 GFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCH 609
QG C++ P + K + DG+ S A GR + +
Sbjct: 275 PGGCDQGQEGCCEECLLRVPPEDIKVCKFGNK-IFQDGEMWSSINCTICACVKGRTECRN 333
Query: 610 NSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVC 652
C S +C K L + C P C E GVC
Sbjct: 334 KQCIPIS--------SCPQGKILNRKGCCPICTE----KPGVC 364
Score = 41.2 bits (95), Expect = 0.021
Identities = 81/352 (23%), Positives = 118/352 (33%), Gaps = 71/352 (20%)
Query: 756 GSCTECHPTCRQCHGPLESD--CISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLC 813
GS +C P +D CI C + L N +C+ E+ C L
Sbjct: 45 GSVAKCENEGEVLQIPFITDNPCIMC---VCL---NKEVTCKREK----------CPVLS 88
Query: 814 QHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQG-RGP 872
+ CA + G+ C +C+ Y G+ AE ++C T G R
Sbjct: 89 RDCALAIKQRGACCEQCKGCTYE--GNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCV 146
Query: 873 FSCSSCDTNLVLSHTGTCSTTC----FPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRDP 928
C + L H G C TC F G + QP + C C T C
Sbjct: 147 VHCKN-----PLEHLGMCCPTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQC--- 198
Query: 929 NKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKT------DCLQCMDGYVL 982
+ C SC PQ+ C C C G K CL D Y
Sbjct: 199 ----VREVCPILSC-PQHLSHIPPGQC------CPKCLGQRKVFDLPFGSCLFRSDVYDN 247
Query: 983 QDGACVEQCLSSFYQDSG-LCKCDSYCLQCQGPHECTR-----CKGPFLLLEAQCVQEC- 1035
+ C + +DS +CK +C P C + C+ L + + ++ C
Sbjct: 248 GSSFLYDNCTACTCRDSTVVCK-----RKCSHPGGCDQGQEGCCEECLLRVPPEDIKVCK 302
Query: 1036 -GKGYFAD---HAKHKCT--ACPQGCLQCSHRDRCHL--CDHGFFL-KSGLC 1078
G F D + CT AC +G +C ++ + C G L + G C
Sbjct: 303 FGNKIFQDGEMWSSINCTICACVKGRTECRNKQCIPISSCPQGKILNRKGCC 354
Score = 35.0 bits (79), Expect = 1.5
Identities = 21/80 (26%), Positives = 32/80 (40%), Gaps = 12/80 (15%)
Query: 20 LPHHSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQC----AFEKGEV 75
+P C + + + D +W +C C C + CRN QC + +G++
Sbjct: 293 VPPEDIKVCKFGNKIFQDGEMWSSINCTICAC-----VKGRTECRNKQCIPISSCPQGKI 347
Query: 76 LQIAANQCCPECVLRTPGSC 95
L CCP C PG C
Sbjct: 348 LN--RKGCCPICT-EKPGVC 364
>gi|20336180 paired basic amino acid cleaving system 4 isoform b
preproprotein [Homo sapiens]
Length = 956
Score = 130 bits (326), Expect = 3e-29
Identities = 87/296 (29%), Positives = 115/296 (38%), Gaps = 37/296 (12%)
Query: 805 YCADCHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CK 858
Y CH C D N CL C H+ L CV CP GY+ + A C+
Sbjct: 678 YTGVCHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCR 734
Query: 859 KCHSSCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC 916
+CH C TC R C SC TC T C G Y D++ C C+ C C
Sbjct: 735 RCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC 794
Query: 917 -DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQ 975
D CT C++ L G C C P Y D C EC +C C GP + +C+
Sbjct: 795 VDEPEKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
Query: 976 CMDGYVLQDGACVEQCLSSFYQDS------GLC-KCDSYCLQCQG-PHECTRCKGPFLLL 1027
C + D CV C FY + +C +CD CL C G C+RCK F L
Sbjct: 853 CAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQL 912
Query: 1028 EAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCV 1083
C+ H C+ + + +R LC+ F++ C C+
Sbjct: 913 GTSCI-----------TNHTCSNADETFCEMVKSNR--LCERKLFIQ--FCCRTCL 953
Score = 127 bits (318), Expect = 3e-28
Identities = 70/226 (30%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
C P+C L C + +CV C G++ D + C CH+ C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575
C CL+CR H C + C GFY Q C C SC C +C
Sbjct: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 801
Query: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634
C E L G C+ +C PG Y+ RC CH++C +C GP C C+
Sbjct: 802 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 861
Query: 635 GHCLPRCGEGFYSD------HGVCKACHSSCLACMGPAPSHCTGCK 674
C+P CGEGFY + H VC+ C +CL+C G + +C+ CK
Sbjct: 862 WKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCK 906
Score = 125 bits (313), Expect = 1e-27
Identities = 83/284 (29%), Positives = 118/284 (41%), Gaps = 48/284 (16%)
Query: 541 GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSECPGGY 597
G C CG D+ CD GP++ +CL C +V KC+S CP GY
Sbjct: 680 GVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSVCPLGY 724
Query: 598 YAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDHGV--C 652
+ D A RC+ CH C +CS + C +C Q C+ C GFY+D C
Sbjct: 725 FGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNC 784
Query: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711
CH SC C+ P CT CK EG + + G C+ C Y +S I C
Sbjct: 785 LKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDSELIRC 832
Query: 712 EACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGP 771
CH +C C G C C + D +C+ C +G++ +E H CR+C
Sbjct: 833 GECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCRRC--- 888
Query: 772 LESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQH 815
+ +C+SC G+ R R + +G +H C +
Sbjct: 889 -DENCLSC-------AGSSRNCSRCKTGFTQLGTSCITNHTCSN 924
Score = 105 bits (263), Expect = 7e-22
Identities = 70/233 (30%), Positives = 99/233 (42%), Gaps = 25/233 (10%)
Query: 415 DCTSVHCHPDCLTCSQSPDHCDLCQDPT-----KLLQNGWCVHSCGLGFY--QAGSLCLA 467
D T V CHP+C + D C + + + CV C LG++ A C
Sbjct: 677 DYTGV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRR 735
Query: 468 CQPQCSTCTS--GLECSSCQPPLL--MRHGQCVPTCGDGFYQD--RHSCAVCHESCAGCW 521
C C TC+S +C SC+ CV C GFY D + +C CH SC C
Sbjct: 736 CHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCV 795
Query: 522 GPTEKHCLACRDPLHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSC-GPSSPRCLTC 578
EK C C++ + R G C C G Y + C C +C +C GP C+ C
Sbjct: 796 DEPEK-CTVCKEGFSLAR-GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHC 853
Query: 579 TEKTVLHDGKCMSECPGGYYADATGR-----CKVCHNSCASCSGPTPSHCTAC 626
+ HD KC+ C G+Y + C+ C +C SC+G + +C+ C
Sbjct: 854 AKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRC 905
Score = 84.7 bits (208), Expect = 2e-15
Identities = 57/200 (28%), Positives = 74/200 (37%), Gaps = 15/200 (7%)
Query: 901 DDNHVCQPCNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNT 954
D+ C+ CG CD + C +C V +C C Y+ D +
Sbjct: 674 DEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARR 732
Query: 955 CKECDWSCSACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCL 1009
C+ C C CS T CL C G+ CV C + FY D KC C
Sbjct: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
Query: 1010 QC-QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHL 1066
+C P +CT CK F L C+ +C G + D +C C C C R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
Query: 1067 CDHGFFLKSGLCVYNCVPGF 1086
C F CV C GF
Sbjct: 853 CAKNFHFHDWKCVPACGEGF 872
Score = 78.6 bits (192), Expect = 1e-13
Identities = 45/144 (31%), Positives = 61/144 (42%), Gaps = 18/144 (12%)
Query: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458
CP G A E + C + CHP C C P+ C +C++ L + G C+ C G
Sbjct: 771 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKEGFSLAR-GSCIPDCEPGT 823
Query: 459 YQAGSL--CLACQPQCSTCT--SGLECSSCQPPLLMRHGQCVPTCGDGFYQD------RH 508
Y L C C C TC EC C +CVP CG+GFY +
Sbjct: 824 YFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHK 883
Query: 509 SCAVCHESCAGCWGPTEKHCLACR 532
C C E+C C G + ++C C+
Sbjct: 884 VCRRCDENCLSCAG-SSRNCSRCK 906
Score = 68.9 bits (167), Expect = 9e-11
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)
Query: 965 CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016
C GP CL C+ G V CV C ++ D+ C+ C C C + +
Sbjct: 691 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 750
Query: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073
C C+ F + CV C G++AD ++ C C C +C ++C +C GF L
Sbjct: 751 CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 810
Query: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101
G C+ +C PG + C HT
Sbjct: 811 ARGSCIPDCEPGTYFDSELIRCGECHHT 838
>gi|4505577 paired basic amino acid cleaving system 4 isoform a
preproprotein [Homo sapiens]
Length = 969
Score = 129 bits (323), Expect = 8e-29
Identities = 86/292 (29%), Positives = 114/292 (39%), Gaps = 37/292 (12%)
Query: 809 CHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CKKCHS 862
CH C D N CL C H+ L CV CP GY+ + A C++CH
Sbjct: 695 CHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 751
Query: 863 SCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC-DSQ 919
C TC R C SC TC T C G Y D++ C C+ C C D
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEP 811
Query: 920 ASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDG 979
CT C++ L G C C P Y D C EC +C C GP + +C+ C
Sbjct: 812 EKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN 869
Query: 980 YVLQDGACVEQCLSSFYQDS------GLC-KCDSYCLQCQG-PHECTRCKGPFLLLEAQC 1031
+ D CV C FY + +C +CD CL C G C+RCK F L C
Sbjct: 870 FHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSRNCSRCKTGFTQLGTSC 929
Query: 1032 VQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCV 1083
+ H C+ + + +R LC+ F++ C C+
Sbjct: 930 I-----------TNHTCSNADETFCEMVKSNR--LCERKLFIQ--FCCRTCL 966
Score = 127 bits (318), Expect = 3e-28
Identities = 70/226 (30%), Positives = 95/226 (42%), Gaps = 20/226 (8%)
Query: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
C P+C L C + +CV C G++ D + C CH+ C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575
C CL+CR H C + C GFY Q C C SC C +C
Sbjct: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
Query: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634
C E L G C+ +C PG Y+ RC CH++C +C GP C C+
Sbjct: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
Query: 635 GHCLPRCGEGFYSD------HGVCKACHSSCLACMGPAPSHCTGCK 674
C+P CGEGFY + H VC+ C +CL+C G + +C+ CK
Sbjct: 875 WKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRCK 919
Score = 125 bits (315), Expect = 6e-28
Identities = 83/289 (28%), Positives = 121/289 (41%), Gaps = 48/289 (16%)
Query: 536 HVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSE 592
++L+ C CG D+ CD GP++ +CL C +V KC+S
Sbjct: 688 NILQTSVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSV 732
Query: 593 CPGGYYAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDH 649
CP GY+ D A RC+ CH C +CS + C +C Q C+ C GFY+D
Sbjct: 733 CPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADE 792
Query: 650 GV--CKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLES 707
C CH SC C+ P CT CK EG + + G C+ C Y +S
Sbjct: 793 SQKNCLKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDS 840
Query: 708 TGI-CEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCR 766
I C CH +C C G C C + D +C+ C +G++ +E H CR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCR 899
Query: 767 QCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQH 815
+C + +C+SC G+ R R + +G +H C +
Sbjct: 900 RC----DENCLSC-------AGSSRNCSRCKTGFTQLGTSCITNHTCSN 937
Score = 107 bits (266), Expect = 3e-22
Identities = 76/284 (26%), Positives = 112/284 (39%), Gaps = 42/284 (14%)
Query: 655 CHSSC--LACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711
CH C C GP C C G S +C++ C ++ ++ C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKT--------SRKCVSVCPLGYFGDTAARRC 746
Query: 712 EACHQSCFRCAGKSPHNCTDC--GPSHVLLDGQCLSQCPDGYFHQEG--SCTECHPTCRQ 767
CH+ C C+ ++ C C G H C++ CP G++ E +C +CHP+C++
Sbjct: 747 RRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKK 806
Query: 768 CHGPLESDCISCYPHISLTNGNCRTSCREEQFLNL-VGYCADCHHLCQHCAADLHNTGSI 826
C E C C SL G+C C + + + C +CHH C C
Sbjct: 807 CVDEPEK-CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE--- 862
Query: 827 CLRC-QNAHYLLLGDHCVPDCPSGYYAE------RGACKKCHSSCRTCQGRGPFSCSSCD 879
C+ C +N H+ CVP C G+Y E C++C +C +C G +CS C
Sbjct: 863 CIHCAKNFHF--HDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAGSSR-NCSRCK 919
Query: 880 TNLVLSHTGTCSTTCFPGHYLDDNHVCQPCN-THCGSCDSQASC 922
T + GT T NH C + T C S C
Sbjct: 920 TG--FTQLGTSCIT---------NHTCSNADETFCEMVKSNRLC 952
Score = 105 bits (263), Expect = 7e-22
Identities = 70/231 (30%), Positives = 99/231 (42%), Gaps = 25/231 (10%)
Query: 417 TSVHCHPDCLTCSQSPDHCDLCQDPT-----KLLQNGWCVHSCGLGFY--QAGSLCLACQ 469
TSV CHP+C + D C + + + CV C LG++ A C C
Sbjct: 692 TSV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCH 750
Query: 470 PQCSTCTS--GLECSSCQPPLL--MRHGQCVPTCGDGFYQD--RHSCAVCHESCAGCWGP 523
C TC+S +C SC+ CV C GFY D + +C CH SC C
Sbjct: 751 KGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDE 810
Query: 524 TEKHCLACRDPLHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSC-GPSSPRCLTCTE 580
EK C C++ + R G C C G Y + C C +C +C GP C+ C +
Sbjct: 811 PEK-CTVCKEGFSLAR-GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAK 868
Query: 581 KTVLHDGKCMSECPGGYYADATGR-----CKVCHNSCASCSGPTPSHCTAC 626
HD KC+ C G+Y + C+ C +C SC+G + +C+ C
Sbjct: 869 NFHFHDWKCVPACGEGFYPEEMPGLPHKVCRRCDENCLSCAG-SSRNCSRC 918
Score = 84.3 bits (207), Expect = 2e-15
Identities = 56/192 (29%), Positives = 72/192 (37%), Gaps = 15/192 (7%)
Query: 909 CNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSC 962
C+ CG CD + C +C V +C C Y+ D + C+ C C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARRCRRCHKGC 753
Query: 963 SACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCLQC-QGPHE 1016
CS T CL C G+ CV C + FY D KC C +C P +
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEK 813
Query: 1017 CTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHLCDHGFFLK 1074
CT CK F L C+ +C G + D +C C C C R+ C C F
Sbjct: 814 CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFH 873
Query: 1075 SGLCVYNCVPGF 1086
CV C GF
Sbjct: 874 DWKCVPACGEGF 885
Score = 78.6 bits (192), Expect = 1e-13
Identities = 45/144 (31%), Positives = 61/144 (42%), Gaps = 18/144 (12%)
Query: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458
CP G A E + C + CHP C C P+ C +C++ L + G C+ C G
Sbjct: 784 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKEGFSLAR-GSCIPDCEPGT 836
Query: 459 YQAGSL--CLACQPQCSTCT--SGLECSSCQPPLLMRHGQCVPTCGDGFYQD------RH 508
Y L C C C TC EC C +CVP CG+GFY +
Sbjct: 837 YFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHK 896
Query: 509 SCAVCHESCAGCWGPTEKHCLACR 532
C C E+C C G + ++C C+
Sbjct: 897 VCRRCDENCLSCAG-SSRNCSRCK 919
Score = 68.9 bits (167), Expect = 9e-11
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)
Query: 965 CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016
C GP CL C+ G V CV C ++ D+ C+ C C C + +
Sbjct: 704 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
Query: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073
C C+ F + CV C G++AD ++ C C C +C ++C +C GF L
Sbjct: 764 CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 823
Query: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101
G C+ +C PG + C HT
Sbjct: 824 ARGSCIPDCEPGTYFDSELIRCGECHHT 851
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 124 bits (312), Expect = 1e-27
Identities = 200/841 (23%), Positives = 277/841 (32%), Gaps = 189/841 (22%)
Query: 395 SCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSC 454
+CPP G C +C V H +C + C C+ + C C
Sbjct: 640 TCPPWAFGP-------GCSEECQCVQPHTQ--SCDKRDGSCS-CKAG---FRGERCQAEC 686
Query: 455 GLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR--HSCAV 512
LG++ G C C TC G+ C S G+C C GF + C V
Sbjct: 687 ELGYFGPG-----CWQAC-TCPVGVACDSVS-------GECGKRCPAGFQGEDCGQECPV 733
Query: 513 ------CHESCAGCWGPTEKHCLACRDPLHVLRDG-GCESSCGKGFYNR--QGTCSACDQ 563
C SC+ P CR P R G CE+ C +G + Q C AC Q
Sbjct: 734 GTFGVNCSSSCSCGGAPCHGVTGQCRCPPG--RTGEDCEADCPEGRWGLGCQEICPAC-Q 790
Query: 564 SCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSG-----P 618
C P + CL C V +C CP G+Y + C C SC+ P
Sbjct: 791 HAARCDPETGACL-CLPGFV--GSRCQDVCPAGWYGPS------CQTRC-SCANDGHCHP 840
Query: 619 TPSHCTACSP-------PKALRQGHCLPRCGE--GFYSDHGVCKACHSSCLACMGPAPSH 669
HC+ C+P +A GH P C + HG C A CL G
Sbjct: 841 ATGHCS-CAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPR 899
Query: 670 CT----------GCKKP---EEGLQVEQLSDV--------------GIPSGECLAQCRAH 702
C GC++ + G + +S P+G CR+
Sbjct: 900 CEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSA 959
Query: 703 FYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECH 762
+ C+A + SC AG+ C + P+H C C SC H
Sbjct: 960 CNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHT-YGHNCSQACA---CFNGASCDPVH 1015
Query: 763 PTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHN 822
C G + C+ P L NCR SC L C + HCA
Sbjct: 1016 GQCHCAPGWMGPSCLQACP-AGLYGDNCRHSC-------LCQNGGTCDPVSGHCACPEGW 1067
Query: 823 TGSICLR----------CQNAHYLLLGDHCVPD-----CPSGYYAERGACKKCHSSC-RT 866
G C + C+++ L G C P CP+G+ + KC S C R
Sbjct: 1068 AGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGD-----KCQSPCLRG 1122
Query: 867 CQGRGPFSCSSCDTNLVLSH-----------TGT-CSTTCFPGHYLDD----------NH 904
G SC H TG+ C C PG + +D N
Sbjct: 1123 WFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENP 1182
Query: 905 VCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSA 964
C P C SC + SC+ +G + C + +C +C
Sbjct: 1183 ACHPATGTC-SCAAGYHGPSCQQRCPPGRYGPGCEQLCG-----CLNGGSCDAATGACRC 1236
Query: 965 CSGPLKTDC-LQCMDGYVLQDGACVEQCLSSFYQD--SGLC---------KCDSYCLQ-- 1010
+G L TDC L C G + V C D +G C +C+ C Q
Sbjct: 1237 PTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNR 1296
Query: 1011 ----CQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKC------TACPQGCLQCSH 1060
C+ H C+ C+ L + CG G+ H + C AC C C +
Sbjct: 1297 FGVGCE--HTCS-CRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLEC-SCHN 1352
Query: 1061 RDRCH------LCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPI 1114
C C GF+ ++ C + C PGF C + P ++G + P
Sbjct: 1353 NSTCEPATGTCRCGPGFYGQA--CEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPA 1410
Query: 1115 G 1115
G
Sbjct: 1411 G 1411
Score = 119 bits (298), Expect = 6e-26
Identities = 274/1180 (23%), Positives = 385/1180 (32%), Gaps = 252/1180 (21%)
Query: 43 PDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGS----CHHE 98
P S Q C C P + P+C ++ E N C + TPGS C
Sbjct: 141 PGSAQPCHC--------PPGFQGPRCQYDVDECR--THNGGCQHRCVNTPGSYLCECKPG 190
Query: 99 KKIH-EHGTEWASSPCSVCS--CNHGEV-------RCTPQPCPPLS-----CGHQELAFI 143
++H + T A + C++ + C H V RC +P L C +
Sbjct: 191 FRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCAN 250
Query: 144 PEGSC---CPVCVGL-------GKPCSYEGHVFQDGEDWR--LSRCA----------KCL 181
GSC C V GL G + +G +D ++ L++CA KC+
Sbjct: 251 RNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGCLNTQGSFKCV 310
Query: 182 CRNGVA------QCFTAQCQPL-FCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQW 234
C G QC+ + + + C + G C CS S E
Sbjct: 311 CHAGYELGADGRQCYRIEMEIVNSCEANN------GGCSHGCSHTSAGPLCTCPRGYELD 364
Query: 235 SENACTTCICDRGEVRCHKQACLP----LRCG-KGQSRARRHGQCCE---ECVSPAGSCS 286
++ + D + C +Q C CG R G CE EC S G C
Sbjct: 365 TDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCE 424
Query: 287 YDGVVRYQDEMWKGSACEF-CMCDHGQVTCQTGE-CAKVECARDEELIHLDGKC------ 338
+ A F C C+ G + C+ +E E ++ LDG+
Sbjct: 425 HHCT---------NLAGSFQCSCEAGYRLHEDRRGCSPLE----EPMVDLDGELPFVRPL 471
Query: 339 ---------CPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCE-CRGAQ 388
P+ + EE E + K + + + C+ CR
Sbjct: 472 PHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGG 531
Query: 389 VTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCD----LCQDPTKL 444
CP G L C PD +C C +C Q+ CD C+ P +
Sbjct: 532 TCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSC-SC-QNGGTCDSVTGACRCPPGV 589
Query: 445 LQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFY 504
C C G+Y C+ +C+ C + C +G C+ C G Y
Sbjct: 590 SGTN-CEDGCPKGYYGK-----HCRKKCN-CANRGRCHRL-------YGACL--CDPGLY 633
Query: 505 QDRHSCAVCHESC-AGCWGP---TEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSA 560
CH +C +GP E C+ RDG C SC GF +
Sbjct: 634 G-----RFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSC--SCKAGFRGER----- 681
Query: 561 CDQSCD--SCGPSSPRCLTCTEKTVLH--DGKCMSECPGGYYADATGR-CKV------CH 609
C C+ GP + TC G+C CP G+ + G+ C V C
Sbjct: 682 CQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCS 741
Query: 610 NSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSH 669
+SC+ P C P C C EG + C C AC H
Sbjct: 742 SSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWG-----LGCQEICPAC-----QH 791
Query: 670 CTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNC 729
C PE G L G C C A +Y S C C H
Sbjct: 792 AARC-DPETG---ACLCLPGFVGSRCQDVCPAGWYGPS------CQTRCSCANDGHCHPA 841
Query: 730 T---DCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHP-TCRQCHGPLESDCISCYPHISL 785
T C P C C G++ + S HP C HG ++ C
Sbjct: 842 TGHCSCAPGWT--GFSCQRACDTGHWGPDCS----HPCNCSAGHGSCDAISGLCLCEAGY 895
Query: 786 TNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD 845
C C + F G + CQH AA H +G+ G C
Sbjct: 896 VGPRCEQQCPQGHF----GPGCEQRCQCQHGAACDHVSGACTCPAG-----WRGTFCEHA 946
Query: 846 CPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCD--TNLVLSHTG----TCSTTCFPGHY 899
CP+G++ C S+C G ++CD L G C+ TC P H
Sbjct: 947 CPAGFFG-----LDCRSACNCTAG------AACDAVNGSCLCPAGRRGPRCAETC-PAHT 994
Query: 900 LDDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTC---- 955
N C+ C +C + ASC DP + G+C CAP + C
Sbjct: 995 YGHN-----CSQAC-ACFNGASC----DP----VHGQCH---CAPGWMGPSCLQACPAGL 1037
Query: 956 --KECDWSCSACSG----PLKTDCLQCMDGYVLQDGACVEQCL----SSFYQDSGLCKCD 1005
C SC +G P+ C C +G+ AC ++CL + + SG C
Sbjct: 1038 YGDNCRHSCLCQNGGTCDPVSGHC-ACPEGWA--GLACEKECLPRDVRAGCRHSGGCLNG 1094
Query: 1006 SYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCH 1065
C PH RC P +C C +G+F + +C +CP G C H
Sbjct: 1095 GLC----DPH-TGRCLCPAGWTGDKCQSPCLRGWFGEACAQRC-SCPPGA-ACHHVTGAC 1147
Query: 1066 LCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGKIHTPSLH 1105
C G F SG C C PG + C P+ H
Sbjct: 1148 RCPPG-FTGSG-CEQACPPGSFGEDCAQMCQCPGENPACH 1185
Score = 89.0 bits (219), Expect = 9e-17
Identities = 222/1015 (21%), Positives = 322/1015 (31%), Gaps = 212/1015 (20%)
Query: 168 DGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFC-----------NQDETVVRVPG---KCC 213
D E + C+ LC +G +C QP C + DE G +C
Sbjct: 119 DEEGCLSAECSASLCFHG-GRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCV 177
Query: 214 PQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQ 273
+ C H + + A +C G + H C+ L + + + R Q
Sbjct: 178 NTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHH---CVQLTITRHRCQCRPGFQ 234
Query: 274 CCEE---CVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEE 330
E+ CV + + +G ++ ++ +G A C C G G+ C +E
Sbjct: 235 LQEDGRHCVRRSPCANRNGSCMHRCQVVRGLAR--CECHVGYQLAADGKA----CEDVDE 288
Query: 331 LIHLDGKCCPECISRNGY--CV----YEETGEFMSSNASEVKRIPEGEKWEDGPCKVCEC 384
+C C++ G CV YE + E++ + E +G C
Sbjct: 289 CAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEA-NNGGCS---- 343
Query: 385 RGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCL-TCSQSPDHCDL-CQDPT 442
G T P C CP G L+ + C D P C C+ +P + C
Sbjct: 344 HGCSHTSAGPLCT-CPRG-YELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGY 401
Query: 443 KLLQNGWCVHSCGL-GFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGD 501
+L +G CG + S C+ C+ +CS C+ G
Sbjct: 402 RLSADG-----CGCEDVDECASSRGGCEHHCTNLAGSFQCS-CE-------------AGY 442
Query: 502 GFYQDRHSCAVCHESCAGCWGPTE-----KHCLACRDPLHVL---RDGGCESS----CGK 549
++DR C+ E G H +D L L D G + G+
Sbjct: 443 RLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGE 502
Query: 550 GFYNRQGTC------SACDQSCDSCGPSSPRCLTCTEKTVLHDGK----CMSECPGGYYA 599
+ C C +CD C + CL + +G C CP +
Sbjct: 503 HTLTEKFVCLDDSFGHDCSLTCDDCR-NGGTCLLGLDGCDCPEGWTGLICNETCPPDTFG 561
Query: 600 DATGRCKVCHNSCASCSGPTPSHCT-ACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSS 658
K C SC+ +G T T AC P + +C C +G+Y H C
Sbjct: 562 ------KNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKH-----CRKK 610
Query: 659 CLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACH--- 715
C C H L L D G+ C C + G E C
Sbjct: 611 C-NCANRGRCH---------RLYGACLCDPGLYGRFCHLTCPPWAF--GPGCSEECQCVQ 658
Query: 716 ---QSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQ-CHGP 771
QSC + G C +C ++C GYF P C Q C P
Sbjct: 659 PHTQSCDKRDGS-------CSCKAGFRGERCQAECELGYFG---------PGCWQACTCP 702
Query: 772 LESDCISCYPHISLTNGNCRTSCREE-------QFLNLVGYCADCHHLCQHCAADLHNTG 824
+ C S +G C C Q + + +C C A H
Sbjct: 703 VGVACDS-------VSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVT 755
Query: 825 SICLRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVL 884
C RC G+ C DCP G + C C CQ + CD
Sbjct: 756 GQC-RCPPGR---TGEDCEADCPEGRWG-----LGCQEICPACQ-----HAARCDPE--- 798
Query: 885 SHTGTCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAP 944
TG C C PG P + SC ++ SC + D + G C SCAP
Sbjct: 799 --TGAC--LCLPGFVGSRCQDVCPAGWYGPSCQTRCSCAN--DGHCHPATGHC---SCAP 849
Query: 945 QYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKC 1004
+ C W CS P C G+ G+C SGLC C
Sbjct: 850 GWTGFSCQRACDTGHWGPD-CSHPCN-----CSAGH----GSCDAI--------SGLCLC 891
Query: 1005 DSYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRC 1064
++ + GP +C Q+C +G+F + +C C G C H
Sbjct: 892 EAGYV------------GP------RCEQQCPQGHFGPGCEQRCQ-CQHGAA-CDHVSGA 931
Query: 1065 HLCDHGFFLKSGLCVYNCVPGFSVHTSNETCSGKIHTPSLHVNGSLILPIGSIKP 1119
C G+ + C + C GF C+ VNGS + P G P
Sbjct: 932 CTCPAGW--RGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGP 984
Score = 70.5 bits (171), Expect = 3e-11
Identities = 139/634 (21%), Positives = 204/634 (32%), Gaps = 142/634 (22%)
Query: 531 CRDPLHVLRDGGCESS-CGKGFYNRQGTCSACDQSCDSCGPS--SPRCLTCTEKTVLHDG 587
CR + + GC S+ C G C C P PRC ++ H+G
Sbjct: 111 CRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNG 170
Query: 588 KC-----------MSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGH 636
C + EC G+ R + NSCA +G HC + + +
Sbjct: 171 GCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLT----ITRHR 226
Query: 637 CLPRCGEGFYSDHGVC----------KACHSSCLACMGPAPSHC-TGCKKPEEGLQVEQL 685
C R G D C +C C G A C G + +G E +
Sbjct: 227 CQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDV 286
Query: 686 SDVGIPSGECLAQCRAHFYLESTG----ICEACHQ------SCFRCAGKSPHNC------ 729
+ LAQC AH L + G +C A ++ C+R + ++C
Sbjct: 287 DECAAG----LAQC-AHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGG 341
Query: 730 TDCGPSHVLLDGQCLSQCPDGY--FHQEGSCTEC-----HPTCRQ--CHGPLESDCISCY 780
G SH C CP GY + +C + P C+Q + P +C CY
Sbjct: 342 CSHGCSHTSAGPLC--TCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYEC-GCY 398
Query: 781 PHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGD 840
L+ C C + V CA C+H +L GS C+ + L
Sbjct: 399 AGYRLSADGC--GCED------VDECASSRGGCEHHCTNL--AGSFQCSCEAGYRL---- 444
Query: 841 HCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTCSTTCFPGHYL 900
+ +R C G PF L H P +
Sbjct: 445 ----------HEDRRGCSPLEEPMVDLDGELPFV-------RPLPHIAVLQDE-LPQLFQ 486
Query: 901 DDNHVCQPCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDW 960
DD+ G+ + +A E + E + ++ + +C
Sbjct: 487 DDD---------VGADEEEA---------------ELRGEHTLTEKFVCLDDSFGHDCSL 522
Query: 961 SCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSYCLQCQGPHECT-- 1018
+C C CL +DG +G C + D+ C S+ CQ C
Sbjct: 523 TCDDCRN--GGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNC-SFSCSCQNGGTCDSV 579
Query: 1019 --RCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCH------LCDHG 1070
C+ P + C C KGY+ H + KC C++R RCH LCD G
Sbjct: 580 TGACRCPPGVSGTNCEDGCPKGYYGKHCRKKC--------NCANRGRCHRLYGACLCDPG 631
Query: 1071 FFLKSGLCVYNCVP-GFSVHTSNETCSGKIHTPS 1103
+ C C P F S E + HT S
Sbjct: 632 LY--GRFCHLTCPPWAFGPGCSEECQCVQPHTQS 663
Score = 48.9 bits (115), Expect = 1e-04
Identities = 135/635 (21%), Positives = 174/635 (27%), Gaps = 140/635 (22%)
Query: 48 SCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTE 107
SC C PA R P+CA + + C C SC
Sbjct: 974 SCLC--------PAGRRGPRCA--ETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPG 1023
Query: 108 WASSPC-SVC-------SCNHGEVRCTPQPCPPLS----CGHQELAFIPEGSCCPVCVGL 155
W C C +C H + C P+S C E C P V
Sbjct: 1024 WMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRA 1083
Query: 156 GKPCSYEGHVFQDG------------EDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDE 203
G C + G G W +C R + +C C
Sbjct: 1084 G--CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCS---CPPGA 1138
Query: 204 TVVRVPG--KCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRC 261
V G +C P + C A GE ++ C C CH
Sbjct: 1139 ACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQ----MCQCPGENPACHPAT------ 1188
Query: 262 GKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACE-FCMC-DHGQVTCQTGE 319
G A HG C++ P RY G CE C C + G TG
Sbjct: 1189 GTCSCAAGYHGPSCQQRCPPG---------RY------GPGCEQLCGCLNGGSCDAATGA 1233
Query: 320 CA------KVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEG-- 371
C +C C C G TG + R G
Sbjct: 1234 CRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCP 1293
Query: 372 -EKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQ 430
++ G C CR + C +G + C P CH +C +C
Sbjct: 1294 QNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLEC-SCHN 1352
Query: 431 SPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLM 490
+ C+ T G C CG GFY AC+ C G + CQ
Sbjct: 1353 N----STCEPAT-----GTC--RCGPGFYGQ-----ACE---HPCPPGFHGAGCQGLCWC 1393
Query: 491 RHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCE-SSCGK 549
+HG A C C P H C + GCE S G+
Sbjct: 1394 QHG-----------------APCDPISGRCLCPAGFHGHFC--------ERGCEPGSFGE 1428
Query: 550 GFYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCH 609
G + R CD CD P P C C +C G + + C
Sbjct: 1429 GCHQR------CD--CDGGAPCDPVTGLCLCPPGRSGATCNLDCRRGQFGPS------CT 1474
Query: 610 NSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEG 644
C C G + C S G+ P C EG
Sbjct: 1475 LHC-DCGG--GADCDPVSGQCHCVDGYMGPTCREG 1506
Score = 33.5 bits (75), Expect = 4.4
Identities = 100/448 (22%), Positives = 129/448 (28%), Gaps = 143/448 (31%)
Query: 22 HHSEGACVYQDSLLADAT-------IWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGE 74
HH GAC + D Q C+C G+ C PA
Sbjct: 1141 HHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPAT-----------G 1189
Query: 75 VLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLS 134
AA P C R P + G E + SC+ C CP
Sbjct: 1190 TCSCAAGYHGPSCQQRCPPGRYGP------GCEQLCGCLNGGSCDAATGACR---CPTGF 1240
Query: 135 CGHQELAFIPEG----SCCPVC-VGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQC 189
G P+G +C VC G G C CLC G A
Sbjct: 1241 LGTDCNLTCPQGRFGPNCTHVCGCGQGAACD--------------PVTGTCLCPPGRA-- 1284
Query: 190 FTAQCQPLFCNQDETVVRVPGKCCPQCSARS---CSAAGQVYEHGEQWSENACTTCICDR 246
+C+ C Q+ R C CS R+ C A+ G W+ C C
Sbjct: 1285 -GVRCE-RGCPQN----RFGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELA-CPP 1337
Query: 247 G--------EVRCHKQA-CLP----LRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRY 293
G E CH + C P RCG G +GQ CE P
Sbjct: 1338 GRYGAACHLECSCHNNSTCEPATGTCRCGPG-----FYGQACEHPCPPG----------- 1381
Query: 294 QDEMWKGSACE-FCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYE 352
+ G+ C+ C C HG C + G+C +C
Sbjct: 1382 ----FHGAGCQGLCWCQHG-APCDP----------------ISGRCLCPAGFHGHFC--- 1417
Query: 353 ETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPC-PVGTLALEVKGQ 411
+R E + +G + C+C G PC PV L L
Sbjct: 1418 -------------ERGCEPGSFGEGCHQRCDCDGG---------APCDPVTGLCL----- 1450
Query: 412 CCPDCTSVHCHPDCLTCSQSPD---HCD 436
C P + C+ DC P HCD
Sbjct: 1451 CPPGRSGATCNLDCRRGQFGPSCTLHCD 1478
>gi|20336182 paired basic amino acid cleaving system 4 isoform g
preproprotein [Homo sapiens]
Length = 975
Score = 117 bits (294), Expect = 2e-25
Identities = 75/245 (30%), Positives = 106/245 (43%), Gaps = 38/245 (15%)
Query: 536 HVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSE 592
++L+ C CG D+ CD GP++ +CL C +V KC+S
Sbjct: 688 NILQTSVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSV 732
Query: 593 CPGGYYAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDH 649
CP GY+ D A RC+ CH C +CS + C +C Q C+ C GFY+D
Sbjct: 733 CPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADE 792
Query: 650 GV--CKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLES 707
C CH SC C+ P CT CK EG + + G C+ C Y +S
Sbjct: 793 SQKNCLKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDS 840
Query: 708 TGI-CEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCR 766
I C CH +C C G C C + D +C+ C +G++ +E H CR
Sbjct: 841 ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCR 899
Query: 767 QCHGP 771
+ +GP
Sbjct: 900 R-YGP 903
Score = 110 bits (276), Expect = 2e-23
Identities = 69/243 (28%), Positives = 92/243 (37%), Gaps = 26/243 (10%)
Query: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
C P+C L C + +CV C G++ D + C CH+ C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 754
Query: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575
C CL+CR H C + C GFY Q C C SC C +C
Sbjct: 755 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 814
Query: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634
C E L G C+ +C PG Y+ RC CH++C +C GP C C+
Sbjct: 815 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 874
Query: 635 GHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGE 694
C+P CGEGFY + M P P G + +S G+P G+
Sbjct: 875 WKCVPACGEGFYPEE-------------MPGLPHKVCRRYGPPGGERQAAVSSKGVPGGQ 921
Query: 695 CLA 697
LA
Sbjct: 922 SLA 924
Score = 108 bits (270), Expect = 1e-22
Identities = 71/226 (31%), Positives = 88/226 (38%), Gaps = 28/226 (12%)
Query: 809 CHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CKKCHS 862
CH C D N CL C H+ L CV CP GY+ + A C++CH
Sbjct: 695 CHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 751
Query: 863 SCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC-DSQ 919
C TC R C SC TC T C G Y D++ C C+ C C D
Sbjct: 752 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEP 811
Query: 920 ASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDG 979
CT C++ L G C C P Y D C EC +C C GP + +C+ C
Sbjct: 812 EKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKN 869
Query: 980 YVLQDGACVEQCLSSFYQDS--GLCKCDSYCLQCQGPHECTRCKGP 1023
+ D CV C FY + GL PH+ R GP
Sbjct: 870 FHFHDWKCVPACGEGFYPEEMPGL------------PHKVCRRYGP 903
Score = 103 bits (257), Expect = 3e-21
Identities = 64/200 (32%), Positives = 80/200 (40%), Gaps = 20/200 (10%)
Query: 607 VCHNSCAS--CSGPTPSHCTAC---SPPKALRQGHCLPRCGEGFYSDHGV--CKACHSSC 659
VCH C C GP C C S C+ C G++ D C+ CH C
Sbjct: 694 VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 753
Query: 660 LACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYL-ESTGICEACHQSC 718
C A + C C++ G Q + C+ C A FY ES C CH SC
Sbjct: 754 ETCSSRAATQCLSCRR---GFYHHQEMNT------CVTLCPAGFYADESQKNCLKCHPSC 804
Query: 719 FRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDG-YFHQEG-SCTECHPTCRQCHGPLESDC 776
+C + P CT C L G C+ C G YF E C ECH TC C GP +C
Sbjct: 805 KKCVDE-PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREEC 863
Query: 777 ISCYPHISLTNGNCRTSCRE 796
I C + + C +C E
Sbjct: 864 IHCAKNFHFHDWKCVPACGE 883
Score = 96.3 bits (238), Expect = 5e-19
Identities = 75/250 (30%), Positives = 99/250 (39%), Gaps = 30/250 (12%)
Query: 417 TSVHCHPDCLTCSQSPDHCDLCQDPT-----KLLQNGWCVHSCGLGFY--QAGSLCLACQ 469
TSV CHP+C + D C + + + CV C LG++ A C C
Sbjct: 692 TSV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCH 750
Query: 470 PQCSTCTS--GLECSSCQPPLL--MRHGQCVPTCGDGFYQD--RHSCAVCHESCAGCWGP 523
C TC+S +C SC+ CV C GFY D + +C CH SC C
Sbjct: 751 KGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDE 810
Query: 524 TEKHCLACRDPLHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSC-GPSSPRCLTCTE 580
EK C C++ + R G C C G Y + C C +C +C GP C+ C +
Sbjct: 811 PEK-CTVCKEGFSLAR-GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAK 868
Query: 581 KTVLHDGKCMSECPGGYYADATGRC--KVCHNSCASCSGPTPSHCTACSPPKALRQGHCL 638
HD KC+ C G+Y + KVC GP A K + G L
Sbjct: 869 NFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR-----YGPPGGERQAAVSSKGVPGGQSL 923
Query: 639 ----PRCGEG 644
P GEG
Sbjct: 924 AASSPGAGEG 933
Score = 90.1 bits (222), Expect = 4e-17
Identities = 57/208 (27%), Positives = 86/208 (41%), Gaps = 23/208 (11%)
Query: 655 CHSSC--LACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711
CH C C GP C C G S +C++ C ++ ++ C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKT--------SRKCVSVCPLGYFGDTAARRC 746
Query: 712 EACHQSCFRCAGKSPHNCTDC--GPSHVLLDGQCLSQCPDGYFHQEG--SCTECHPTCRQ 767
CH+ C C+ ++ C C G H C++ CP G++ E +C +CHP+C++
Sbjct: 747 RRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKK 806
Query: 768 CHGPLESDCISCYPHISLTNGNCRTSCREEQFLNL-VGYCADCHHLCQHCAADLHNTGSI 826
C E C C SL G+C C + + + C +CHH C C
Sbjct: 807 CVDEPEK-CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREE--- 862
Query: 827 CLRC-QNAHYLLLGDHCVPDCPSGYYAE 853
C+ C +N H+ CVP C G+Y E
Sbjct: 863 CIHCAKNFHF--HDWKCVPACGEGFYPE 888
Score = 84.3 bits (207), Expect = 2e-15
Identities = 56/192 (29%), Positives = 72/192 (37%), Gaps = 15/192 (7%)
Query: 909 CNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSC 962
C+ CG CD + C +C V +C C Y+ D + C+ C C
Sbjct: 695 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARRCRRCHKGC 753
Query: 963 SACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCLQC-QGPHE 1016
CS T CL C G+ CV C + FY D KC C +C P +
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEK 813
Query: 1017 CTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHLCDHGFFLK 1074
CT CK F L C+ +C G + D +C C C C R+ C C F
Sbjct: 814 CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFH 873
Query: 1075 SGLCVYNCVPGF 1086
CV C GF
Sbjct: 874 DWKCVPACGEGF 885
Score = 82.8 bits (203), Expect = 6e-15
Identities = 59/197 (29%), Positives = 83/197 (42%), Gaps = 17/197 (8%)
Query: 860 CHSSC--RTCQGRGPFSCSSCDTNLVLSHTGT---CSTTCFPGHYLDDN-HVCQPCNTHC 913
CH C + C G C +C + L T C + C G++ D C+ C+ C
Sbjct: 695 CHPECGDKGCDGPNADQCLNC-VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 753
Query: 914 GSCDSQAS--CTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSAC-SGPLK 970
+C S+A+ C SCR C +Y D S C +C SC C P K
Sbjct: 754 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEK 813
Query: 971 TDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSY---CLQCQGP--HECTRCKGPFL 1025
C C +G+ L G+C+ C Y DS L +C C C GP EC C F
Sbjct: 814 --CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 871
Query: 1026 LLEAQCVQECGKGYFAD 1042
+ +CV CG+G++ +
Sbjct: 872 FHDWKCVPACGEGFYPE 888
Score = 68.9 bits (167), Expect = 9e-11
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)
Query: 965 CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016
C GP CL C+ G V CV C ++ D+ C+ C C C + +
Sbjct: 704 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 763
Query: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073
C C+ F + CV C G++AD ++ C C C +C ++C +C GF L
Sbjct: 764 CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 823
Query: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101
G C+ +C PG + C HT
Sbjct: 824 ARGSCIPDCEPGTYFDSELIRCGECHHT 851
Score = 67.8 bits (164), Expect = 2e-10
Identities = 37/112 (33%), Positives = 48/112 (42%), Gaps = 11/112 (9%)
Query: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458
CP G A E + C + CHP C C P+ C +C++ L + G C+ C G
Sbjct: 784 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKEGFSLAR-GSCIPDCEPGT 836
Query: 459 YQAGSL--CLACQPQCSTCT--SGLECSSCQPPLLMRHGQCVPTCGDGFYQD 506
Y L C C C TC EC C +CVP CG+GFY +
Sbjct: 837 YFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPE 888
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 117 bits (293), Expect = 2e-25
Identities = 168/687 (24%), Positives = 230/687 (33%), Gaps = 160/687 (23%)
Query: 499 CGDGFYQDRHSCA-VCHESCAG--CWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQ 555
C GFY+ R C +C + C C P + C+ R C S C G + Q
Sbjct: 90 CCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPG------WRGDDCSSECAPGMWGPQ 143
Query: 556 GTCSACDQSCDSCGPSS---PRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSC 612
CD+ C SCG +S P+ C+ + L C+ C GYY A C C
Sbjct: 144 -----CDKPC-SCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPA------CQFRC 191
Query: 613 ASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTG 672
P AC P C C +G + C + HS + P
Sbjct: 192 QCHGAPCDPQTGACFCPAERTGPSCDVSCSQG--TSGFFCPSTHSCQNGGVFQTPQGSCS 249
Query: 673 CKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCA---------- 722
C G G C +CR H + G+C+ C RCA
Sbjct: 250 CPPGWMGTICSLPCPEGFHGPNCSQECRCH----NGGLCDRFTGQC-RCAPGYTGDRCRE 304
Query: 723 ----GKSPHNCT---DCGPSHVLL--DGQCLSQ------------CPDGYF--HQEGSCT 759
G+ +C DC P +G CL + CPDG++ + CT
Sbjct: 305 ECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCT 364
Query: 760 ECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCADCHHLCQH---C 816
CH P+ +C SC P +C SC ++ G H LC H C
Sbjct: 365 CDREHSLSCH-PMNGEC-SCLP--GWAGLHCNESCPQDTH----GPGCQEHCLCLHGGVC 416
Query: 817 AADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYA----------ERGACKKCHSSCRT 866
A T +C +C + G HC CP Y AC C
Sbjct: 417 QA----TSGLC-QCAPGY---TGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVC 468
Query: 867 CQGRGPFSCS----------SCDTNLVLSHTGTCS-----TTCFPGHYLDDNHVCQPC-- 909
+G +CS SC+ + +H CS TC PG + H PC
Sbjct: 469 KEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWH--GAHCQLPCPK 526
Query: 910 ---NTHCGS---CDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKE------ 957
C S CD C DP + G CQ C + +C E
Sbjct: 527 GQFGEGCASRCDCDHSDGC----DP----VHGRCQ---CQAGWMGARCHLSCPEGLWGVN 575
Query: 958 CDWSCSACSG----PLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSGL-CKC--DSYCLQ 1010
C +C+ +G P +C+ C G+ + +C C Y + CKC S+C
Sbjct: 576 CSNTCTCKNGGTCLPENGNCV-CAPGF--RGPSCQRSCQPGRYGKRCVPCKCANHSFCHP 632
Query: 1011 CQGPHEC-TRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDH 1069
G C GP C Q C G++ ++ C Q C QC H CH D
Sbjct: 633 SNGTCYCLAGWTGP------DCSQPCPPGHWGEN-------CAQTC-QCHHGGTCHPQDG 678
Query: 1070 GFFLKSGLCVYNCVPGFSVHTSNETCS 1096
G ++C+ G + T CS
Sbjct: 679 SCICPLGWTGHHCLEGCPLGTFGANCS 705
Score = 83.2 bits (204), Expect = 5e-15
Identities = 188/753 (24%), Positives = 248/753 (32%), Gaps = 176/753 (23%)
Query: 66 PQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRC 125
P CA E +A NQC +CV PG W CS C G
Sbjct: 103 PLCAQECVHGRCVAPNQC--QCV---PG--------------WRGDDCS-SECAPG--MW 140
Query: 126 TPQPCPPLSCGHQELAFIPEGSCC-------PVCVGLGKPCS--YEGHVFQDGEDWRLSR 176
PQ P SCG+ G C P C+ +PC+ Y G Q R
Sbjct: 141 GPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCL---QPCTPGYYGPACQ-------FR 190
Query: 177 CAKCLCRNGVAQCFTAQCQP----LFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGE 232
C QC A C P FC + T C S C + G
Sbjct: 191 C----------QCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV 240
Query: 233 QWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHG-QCCEECVSPAGSCSYDGVV 291
+ +C C G + L C +G HG C +EC C G+
Sbjct: 241 FQTPQG--SCSCPPGWMG----TICSLPCPEGF-----HGPNCSQEC-----RCHNGGLC 284
Query: 292 RYQDEMWKGSACEFCMCDHGQVTCQTGECAKVEC--ARDEELIHLDGKCCPE--CISRNG 347
+ + G C C G TG+ + EC R + C P+ C NG
Sbjct: 285 ----DRFTGQ----CRCAPGY----TGDRCREECPVGRFGQDCAETCDCAPDARCFPANG 332
Query: 348 YCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKV-CEC-RGAQVTCYEPSCPPCPVGTLA 405
C+ E F ++ + P+G + C+ C C R ++C+ P C
Sbjct: 333 ACLCEHG--FTGDRCTD-RLCPDG--FYGLSCQAPCTCDREHSLSCH-PMNGEC------ 380
Query: 406 LEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLC 465
C P +HC+ C + P CQ+ L G C + GL G
Sbjct: 381 -----SCLPGWAGLHCNESCPQDTHGPG----CQEHCLCLHGGVCQATSGLCQCAPGYTG 431
Query: 466 LACQPQCSTCTSGLECS---SCQPPLLMR--HGQCVPTCGDGFYQDRHSCAV-------- 512
C C T G+ CS SC+ + G+CV C +G+ R +C+V
Sbjct: 432 PHCASLCPPDTYGVNCSARCSCENAIACSPIDGECV--CKEGW--QRGNCSVPCPPGTWG 487
Query: 513 --CHESC-----AGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACD-QS 564
C+ SC A C P C C H C+ C KG + +G S CD
Sbjct: 488 FSCNASCQCAHEAVC-SPQTGAC-TCTPGWH---GAHCQLPCPKGQFG-EGCASRCDCDH 541
Query: 565 CDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSG----PTP 620
D C P RC C + +C CP G + C N+C +G P
Sbjct: 542 SDGCDPVHGRC-QCQAGWM--GARCHLSCPEGLWG------VNCSNTCTCKNGGTCLPEN 592
Query: 621 SHCTACSPPKALRQGHCLPRCGEGFYSDHGV-CK-ACHSSCLACMGPAPSHCTGCKKPEE 678
+C C+P R C C G Y V CK A HS C P+ C C
Sbjct: 593 GNC-VCAP--GFRGPSCQRSCQPGRYGKRCVPCKCANHSFC----HPSNGTCY-CLAGWT 644
Query: 679 GLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVL 738
G Q G C C+ H G C SC G + H+C + P
Sbjct: 645 GPDCSQPCPPGHWGENCAQTCQCH----HGGTCHPQDGSCICPLGWTGHHCLEGCPLGT- 699
Query: 739 LDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGP 771
C C Q G +CHP C P
Sbjct: 700 FGANCSQPC------QCGPGEKCHPETGACVCP 726
Score = 55.5 bits (132), Expect = 1e-06
Identities = 124/517 (23%), Positives = 165/517 (31%), Gaps = 148/517 (28%)
Query: 43 PDSCQSCRCHGDIVICKPAVCR--NPQCAFEKGEVLQIAANQCCPEC-VLRTPGSCHHEK 99
P+ Q CRCH +C QC G ++C EC V R C
Sbjct: 270 PNCSQECRCHNG------GLCDRFTGQCRCAPG----YTGDRCREECPVGRFGQDCAETC 319
Query: 100 KIHEHGTEWASSPCSVCSCNHGEV--RCTPQPCP----------PLSCGHQ-ELAFIP-- 144
+ ++ C C HG RCT + CP P +C + L+ P
Sbjct: 320 DCAPDARCFPAN--GACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMN 377
Query: 145 -EGSCCPVCVGL--GKPCSYEGHVFQDGEDWRLSRCAKCLC-RNGVAQCFTAQCQPLFCN 200
E SC P GL + C + H G + CLC GV Q + CQ C
Sbjct: 378 GECSCLPGWAGLHCNESCPQDTH----GPGCQ----EHCLCLHGGVCQATSGLCQ---CA 426
Query: 201 QDETVVRVPGKCCP-----QCSARSCSAAGQVYEHGEQWSENACT----TCICDRGEVRC 251
T C P CSAR CS + AC+ C+C G R
Sbjct: 427 PGYTGPHCASLCPPDTYGVNCSAR-CSCENAI----------ACSPIDGECVCKEGWQR- 474
Query: 252 HKQACLPLRCGKGQSRARRHGQCCEE--CVSPAGSCSYDGVVRYQDEMWKGSACEF---- 305
+P G QC E C G+C+ W G+ C+
Sbjct: 475 -GNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTC-------TPGWHGAHCQLPCPK 526
Query: 306 ----------CMCD--------HGQVTCQTGEC-AKVECARDEELIHLDGKCCPECISRN 346
C CD HG+ CQ G A+ + E L ++ C C +N
Sbjct: 527 GQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVN--CSNTCTCKN 584
Query: 347 GYCVYEETGEFMSS---NASEVKRIPEGEKWEDG--PCKVCE---CRGAQVTCY------ 392
G E G + + +R + ++ PCK C + TCY
Sbjct: 585 GGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWT 644
Query: 393 EPSC-PPCPVGTLALEVKGQCCPDCTSVH---CHPDCLTCSQSPDHCDLCQDPTKLLQNG 448
P C PCP G C C H CHP QD + + G
Sbjct: 645 GPDCSQPCPPGHWG----ENCAQTCQCHHGGTCHP---------------QDGSCICPLG 685
Query: 449 W----CVHSCGLGFYQAGSLCLACQPQCSTCTSGLEC 481
W C+ C LG + A C C C G +C
Sbjct: 686 WTGHHCLEGCPLGTFGAN-----CSQPCQ-CGPGEKC 716
Score = 55.1 bits (131), Expect = 1e-06
Identities = 81/306 (26%), Positives = 106/306 (34%), Gaps = 73/306 (23%)
Query: 839 GDHCVPDCPSGYYAERGACKKCHSSCRTCQGRGPFS-CSSCDTNLVLSHTGTCSTTCFPG 897
GD C +C G + + C K SC P S SC + L C C PG
Sbjct: 128 GDDCSSECAPGMWGPQ--CDK-PCSCGNNSSCDPKSGVCSCPSGL---QPPNCLQPCTPG 181
Query: 898 HYLDDNHVCQ-PCNTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDF--STNT 954
+Y CQ C H CD Q C G SC+ F ST++
Sbjct: 182 YY---GPACQFRCQCHGAPCDPQTGACFCPAERT----GPSCDVSCSQGTSGFFCPSTHS 234
Query: 955 CKEC------DWSCSACSGPLKTDC-LQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSY 1007
C+ SCS G + T C L C +G+ C ++C + GLC D +
Sbjct: 235 CQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGF--HGPNCSQECRC---HNGGLC--DRF 287
Query: 1008 CLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQ-------GCLQCSH 1060
QC RC + +C +EC G F C P G C H
Sbjct: 288 TGQC-------RCAPGYT--GDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEH 338
Query: 1061 R---DRC--HLCDHGFFLKS-------------------GLCVYNCVPGFSVHTSNETCS 1096
DRC LC GF+ S G C +C+PG++ NE+C
Sbjct: 339 GFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGEC--SCLPGWAGLHCNESCP 396
Query: 1097 GKIHTP 1102
H P
Sbjct: 397 QDTHGP 402
Score = 33.5 bits (75), Expect = 4.4
Identities = 41/186 (22%), Positives = 57/186 (30%), Gaps = 58/186 (31%)
Query: 974 LQCMDGYVLQDGACV----EQCLSSFYQDSGLCK---------CDSYCL------QCQGP 1014
LQC G+ G CV ++C+ C+ C S C QC P
Sbjct: 88 LQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKP 147
Query: 1015 HECTR----------CKGPFLLLEAQCVQECGKGYFADHAKHKC---------------- 1048
C C P L C+Q C GY+ + +C
Sbjct: 148 CSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFC 207
Query: 1049 ------TACPQGCLQCSHRDRC---HLCDHG--FFLKSGLCVYNCVPGFSVHTSNETCSG 1097
+C C Q + C H C +G F G C +C PG+ + C
Sbjct: 208 PAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSC--SCPPGWMGTICSLPCPE 265
Query: 1098 KIHTPS 1103
H P+
Sbjct: 266 GFHGPN 271
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 117 bits (292), Expect = 3e-25
Identities = 127/538 (23%), Positives = 194/538 (36%), Gaps = 128/538 (23%)
Query: 23 HSEGACVYQDSLLADATIWKP-DSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAAN 81
H E C L D W D C++C C V C+ C C+ + V A
Sbjct: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPV--HIAG 325
Query: 82 QCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
QCC C C + K+ G + C C G + + CPPL+C ++
Sbjct: 326 QCCKVC----RPKCIYGGKVLAEGQRILTKSCR--ECRGGVLVKITEMCPPLNCSEKD-H 378
Query: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGV--AQCFTAQCQPL-- 197
+PE CC VC G C+ ++ E + A C C++G Q +A C+ +
Sbjct: 379 ILPENQCCRVCRG-HNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE 437
Query: 198 ------FCNQDETVVRVPG----KCCP---QCSARSCSAAGQVYEHGEQWSENACTTCIC 244
+C+ + V +PG C P + SC+ + ENA T
Sbjct: 438 CAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICT--- 494
Query: 245 DRGEVRCHKQACLPLRCGKG-------QSRARRHGQC----------------CE----- 276
V+ H C P G G + R G C CE
Sbjct: 495 --NTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
Query: 277 ---------------------ECVSP-----AGSCSYDGVVRYQDEMW--KGSACEFCMC 308
+C+ P +G C ++G +++ ++W K C C C
Sbjct: 553 CALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSC 612
Query: 309 DHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRI 368
G++ C+ C +C D CCPEC +R T + + N ++ R
Sbjct: 613 KDGKIFCRRTAC---DCQNPS----ADLFCCPECDTR-------VTSQCLDQNGHKLYR- 657
Query: 369 PEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTC 428
G+ W C+ C C +V C+ +CP A+ ++G+CCP C S C D +T
Sbjct: 658 -SGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSCEYTAI-LEGECCPRCVSDPCLADNITY 714
Query: 429 SQSPDHCDLCQDP---TKLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSS 483
D C D ++L + W + AGS C C+ C +G C S
Sbjct: 715 ----DIRKTCLDSYGVSRLSGSVWTM---------AGSPCTTCK-----CKNGRVCCS 754
Score = 85.9 bits (211), Expect = 7e-16
Identities = 113/525 (21%), Positives = 172/525 (32%), Gaps = 119/525 (22%)
Query: 219 RSCSAAGQVYEHGEQWSE-NACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEE 277
++C +G +Y + W + + C C C G V C + +C PL C GQCC+
Sbjct: 271 KTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKV 330
Query: 278 CVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGK 337
C C Y G V + + +C C G + T C + C+ + ++ + +
Sbjct: 331 C---RPKCIYGGKVLAEGQRILTKSCRECR--GGVLVKITEMCPPLNCSEKDHILP-ENQ 384
Query: 338 CCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW-EDGPCK------VCECRGAQVT 390
CC C N +C EG K E+ CK CEC+ ++
Sbjct: 385 CCRVCRGHN-FCA-------------------EGPKCGENSECKNWNTKATCECKSGYIS 424
Query: 391 CYEPS--------CPP----CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPD----- 433
S C C T+ + + G DC + D +C++ +
Sbjct: 425 VQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQ 484
Query: 434 -HCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLA-CQPQC---STCTSGLECSSCQPPL 488
+CD T +Q C +C G+ G++C A C+ C TC + +C
Sbjct: 485 HNCDENAICTNTVQGHSC--TCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC------- 535
Query: 489 LMRHGQCVPTCGDGFYQDRHSCAVCHESCA----GCWGPTEKHCLACRDPLHVLRDGG-- 542
C GF C + CA CW + C+ L G
Sbjct: 536 ---------VCPSGFTGSH--CEKDIDECALRTHTCWN--DSACINLAGGFDCLCPSGPS 582
Query: 543 CESSC---------GKGFYNRQGTCSACD----------QSCDSCGPSSPRCLTCTEKTV 583
C C G+ + ++ CS C +CD PS+ C E
Sbjct: 583 CSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPSAD-LFCCPECDT 641
Query: 584 LHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPT---PSHCTACSPP-KALRQGHCLP 639
+C+ + Y C C G P C S A+ +G C P
Sbjct: 642 RVTSQCLDQNGHKLYRSGDNWTHSCQQ-CRCLEGEVDCWPLTCPNLSCEYTAILEGECCP 700
Query: 640 RCGEGFYSDHGVCKACHSSCLACMG----------PAPSHCTGCK 674
RC + +CL G A S CT CK
Sbjct: 701 RCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCK 745
Score = 51.6 bits (122), Expect = 2e-05
Identities = 98/429 (22%), Positives = 156/429 (36%), Gaps = 86/429 (20%)
Query: 692 SGECLAQCRAHFYLESTGICEACH---QSCFRCAGK---------SPHNCTDCGPSHVLL 739
+G+C CR + E +SC C G P NC++ H+L
Sbjct: 324 AGQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSE--KDHILP 381
Query: 740 DGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCR-EEQ 798
+ QC C F EG P C + S+C N N + +C +
Sbjct: 382 ENQCCRVCRGHNFCAEG------PKCGE-----NSEC---------KNWNTKATCECKSG 421
Query: 799 FLNLVGYCADCHHLCQHCAADLH--NTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGA 856
++++ G A C + CAA +H + ++C+ + C DC GY
Sbjct: 422 YISVQGDSAYCEDI-DECAAKMHYCHANTVCVNLPGLY------RC--DCVPGYIRVDDF 472
Query: 857 CKKCHSSCRTCQGRGPFSC--SSCDTNLVLSHTGTCSTTCFPGHYLDDNHVCQP-CNTHC 913
H C G G +C ++ TN V H S TC PG Y+ + +C+ C C
Sbjct: 473 SCTEHDEC----GSGQHNCDENAICTNTVQGH----SCTCKPG-YVGNGTICRAFCEEGC 523
Query: 914 ---GSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKEC--DWSCSACSGP 968
G+C + C E + CA + + ++ + C + C SGP
Sbjct: 524 RYGGTCVAPNKCVC--PSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLCPSGP 581
Query: 969 -LKTDCLQCMDGYVLQDGAC----VEQCLSSFYQDSGLCKCDSYCLQCQGPHE----CTR 1019
DC +G + +G ++C +D G C CQ P C
Sbjct: 582 SCSGDCPH--EGGLKHNGQVWTLKEDRCSVCSCKD-GKIFCRRTACDCQNPSADLFCCPE 638
Query: 1020 CKGPFLLLEAQCVQECGKGYF--ADHAKHKCTACP--QGCLQCSHRDRCHL-CDHGFFLK 1074
C + +QC+ + G + D+ H C C +G + C +L C++ L+
Sbjct: 639 CD---TRVTSQCLDQNGHKLYRSGDNWTHSCQQCRCLEGEVDCWPLTCPNLSCEYTAILE 695
Query: 1075 SGLCVYNCV 1083
G C CV
Sbjct: 696 -GECCPRCV 703
>gi|20336184 paired basic amino acid cleaving system 4 isoform h
preproprotein [Homo sapiens]
Length = 962
Score = 117 bits (292), Expect = 3e-25
Identities = 75/240 (31%), Positives = 103/240 (42%), Gaps = 38/240 (15%)
Query: 541 GGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE---KTVLHDGKCMSECPGGY 597
G C CG D+ CD GP++ +CL C +V KC+S CP GY
Sbjct: 680 GVCHPECG-------------DKGCD--GPNADQCLNCVHFSLGSVKTSRKCVSVCPLGY 724
Query: 598 YAD-ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ--GHCLPRCGEGFYSDHGV--C 652
+ D A RC+ CH C +CS + C +C Q C+ C GFY+D C
Sbjct: 725 FGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNC 784
Query: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGI-C 711
CH SC C+ P CT CK EG + + G C+ C Y +S I C
Sbjct: 785 LKCHPSCKKCVDE-PEKCTVCK---EGFSLAR--------GSCIPDCEPGTYFDSELIRC 832
Query: 712 EACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGP 771
CH +C C G C C + D +C+ C +G++ +E H CR+ +GP
Sbjct: 833 GECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLP-HKVCRR-YGP 890
Score = 110 bits (276), Expect = 2e-23
Identities = 69/243 (28%), Positives = 92/243 (37%), Gaps = 26/243 (10%)
Query: 468 CQPQCS-------TCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHS--CAVCHESCA 518
C P+C L C + +CV C G++ D + C CH+ C
Sbjct: 682 CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCE 741
Query: 519 GCWGPTEKHCLACRDPL-HVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGPSSPRC 575
C CL+CR H C + C GFY Q C C SC C +C
Sbjct: 742 TCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKC 801
Query: 576 LTCTEKTVLHDGKCMSEC-PGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ 634
C E L G C+ +C PG Y+ RC CH++C +C GP C C+
Sbjct: 802 TVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHD 861
Query: 635 GHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGE 694
C+P CGEGFY + M P P G + +S G+P G+
Sbjct: 862 WKCVPACGEGFYPEE-------------MPGLPHKVCRRYGPPGGERQAAVSSKGVPGGQ 908
Query: 695 CLA 697
LA
Sbjct: 909 SLA 911
Score = 109 bits (273), Expect = 5e-23
Identities = 72/230 (31%), Positives = 89/230 (38%), Gaps = 28/230 (12%)
Query: 805 YCADCHHLCQHCAADLHNTGSICLRCQNAHYLL----LGDHCVPDCPSGYYAERGA--CK 858
Y CH C D N CL C H+ L CV CP GY+ + A C+
Sbjct: 678 YTGVCHPECGDKGCDGPNADQ-CLNC--VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCR 734
Query: 859 KCHSSCRTCQGRGPFSCSSCDTNLVL-SHTGTCSTTCFPGHYLDDNHV-CQPCNTHCGSC 916
+CH C TC R C SC TC T C G Y D++ C C+ C C
Sbjct: 735 RCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKC 794
Query: 917 -DSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQ 975
D CT C++ L G C C P Y D C EC +C C GP + +C+
Sbjct: 795 VDEPEKCTVCKEGFS-LARGSC-IPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
Query: 976 CMDGYVLQDGACVEQCLSSFYQDS--GLCKCDSYCLQCQGPHECTRCKGP 1023
C + D CV C FY + GL PH+ R GP
Sbjct: 853 CAKNFHFHDWKCVPACGEGFYPEEMPGL------------PHKVCRRYGP 890
Score = 103 bits (258), Expect = 3e-21
Identities = 67/207 (32%), Positives = 83/207 (40%), Gaps = 23/207 (11%)
Query: 600 DATGRCKVCHNSCAS--CSGPTPSHCTAC---SPPKALRQGHCLPRCGEGFYSDHGV--C 652
D TG VCH C C GP C C S C+ C G++ D C
Sbjct: 677 DYTG---VCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRC 733
Query: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYL-ESTGIC 711
+ CH C C A + C C++ G Q + C+ C A FY ES C
Sbjct: 734 RRCHKGCETCSSRAATQCLSCRR---GFYHHQEMNT------CVTLCPAGFYADESQKNC 784
Query: 712 EACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDG-YFHQEG-SCTECHPTCRQCH 769
CH SC +C + P CT C L G C+ C G YF E C ECH TC C
Sbjct: 785 LKCHPSCKKCVDE-PEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCV 843
Query: 770 GPLESDCISCYPHISLTNGNCRTSCRE 796
GP +CI C + + C +C E
Sbjct: 844 GPGREECIHCAKNFHFHDWKCVPACGE 870
Score = 96.3 bits (238), Expect = 5e-19
Identities = 75/252 (29%), Positives = 99/252 (39%), Gaps = 30/252 (11%)
Query: 415 DCTSVHCHPDCLTCSQSPDHCDLCQDPT-----KLLQNGWCVHSCGLGFY--QAGSLCLA 467
D T V CHP+C + D C + + + CV C LG++ A C
Sbjct: 677 DYTGV-CHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRR 735
Query: 468 CQPQCSTCTS--GLECSSCQPPLL--MRHGQCVPTCGDGFYQD--RHSCAVCHESCAGCW 521
C C TC+S +C SC+ CV C GFY D + +C CH SC C
Sbjct: 736 CHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCV 795
Query: 522 GPTEKHCLACRDPLHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSC-GPSSPRCLTC 578
EK C C++ + R G C C G Y + C C +C +C GP C+ C
Sbjct: 796 DEPEK-CTVCKEGFSLAR-GSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHC 853
Query: 579 TEKTVLHDGKCMSECPGGYYADATGRC--KVCHNSCASCSGPTPSHCTACSPPKALRQGH 636
+ HD KC+ C G+Y + KVC GP A K + G
Sbjct: 854 AKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR-----YGPPGGERQAAVSSKGVPGGQ 908
Query: 637 CL----PRCGEG 644
L P GEG
Sbjct: 909 SLAASSPGAGEG 920
Score = 84.7 bits (208), Expect = 2e-15
Identities = 57/200 (28%), Positives = 74/200 (37%), Gaps = 15/200 (7%)
Query: 901 DDNHVCQPCNTHCGS--CDSQAS--CTSCR--DPNKVLLFGECQYESCAPQYYLDFSTNT 954
D+ C+ CG CD + C +C V +C C Y+ D +
Sbjct: 674 DEEDYTGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKC-VSVCPLGYFGDTAARR 732
Query: 955 CKECDWSCSACSGPLKTDCLQCMDGYVLQD--GACVEQCLSSFYQDSG---LCKCDSYCL 1009
C+ C C CS T CL C G+ CV C + FY D KC C
Sbjct: 733 CRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCK 792
Query: 1010 QC-QGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQC--SHRDRCHL 1066
+C P +CT CK F L C+ +C G + D +C C C C R+ C
Sbjct: 793 KCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIH 852
Query: 1067 CDHGFFLKSGLCVYNCVPGF 1086
C F CV C GF
Sbjct: 853 CAKNFHFHDWKCVPACGEGF 872
Score = 82.8 bits (203), Expect = 6e-15
Identities = 59/197 (29%), Positives = 83/197 (42%), Gaps = 17/197 (8%)
Query: 860 CHSSC--RTCQGRGPFSCSSCDTNLVLSHTGT---CSTTCFPGHYLDDN-HVCQPCNTHC 913
CH C + C G C +C + L T C + C G++ D C+ C+ C
Sbjct: 682 CHPECGDKGCDGPNADQCLNC-VHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGC 740
Query: 914 GSCDSQAS--CTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSAC-SGPLK 970
+C S+A+ C SCR C +Y D S C +C SC C P K
Sbjct: 741 ETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEK 800
Query: 971 TDCLQCMDGYVLQDGACVEQCLSSFYQDSGLCKCDSY---CLQCQGP--HECTRCKGPFL 1025
C C +G+ L G+C+ C Y DS L +C C C GP EC C F
Sbjct: 801 --CTVCKEGFSLARGSCIPDCEPGTYFDSELIRCGECHHTCGTCVGPGREECIHCAKNFH 858
Query: 1026 LLEAQCVQECGKGYFAD 1042
+ +CV CG+G++ +
Sbjct: 859 FHDWKCVPACGEGFYPE 875
Score = 68.9 bits (167), Expect = 9e-11
Identities = 42/148 (28%), Positives = 62/148 (41%), Gaps = 11/148 (7%)
Query: 965 CSGPLKTDCLQCMD---GYVLQDGACVEQCLSSFYQDSGL--CK-CDSYCLQC--QGPHE 1016
C GP CL C+ G V CV C ++ D+ C+ C C C + +
Sbjct: 691 CDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQ 750
Query: 1017 CTRCKGPFLLLEAQ--CVQECGKGYFADHAKHKCTACPQGCLQC-SHRDRCHLCDHGFFL 1073
C C+ F + CV C G++AD ++ C C C +C ++C +C GF L
Sbjct: 751 CLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSL 810
Query: 1074 KSGLCVYNCVPGFSVHTSNETCSGKIHT 1101
G C+ +C PG + C HT
Sbjct: 811 ARGSCIPDCEPGTYFDSELIRCGECHHT 838
Score = 67.8 bits (164), Expect = 2e-10
Identities = 37/112 (33%), Positives = 48/112 (42%), Gaps = 11/112 (9%)
Query: 399 CPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGF 458
CP G A E + C + CHP C C P+ C +C++ L + G C+ C G
Sbjct: 771 CPAGFYADESQKNC------LKCHPSCKKCVDEPEKCTVCKEGFSLAR-GSCIPDCEPGT 823
Query: 459 YQAGSL--CLACQPQCSTCT--SGLECSSCQPPLLMRHGQCVPTCGDGFYQD 506
Y L C C C TC EC C +CVP CG+GFY +
Sbjct: 824 YFDSELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPE 875
Score = 54.7 bits (130), Expect = 2e-06
Identities = 34/106 (32%), Positives = 46/106 (43%), Gaps = 9/106 (8%)
Query: 999 SGLCKCDSYCLQCQGPH--ECTRCKGPFL---LLEAQCVQECGKGYFADHAKHKCTACPQ 1053
+G+C + C GP+ +C C L +CV C GYF D A +C C +
Sbjct: 679 TGVCHPECGDKGCDGPNADQCLNCVHFSLGSVKTSRKCVSVCPLGYFGDTAARRCRRCHK 738
Query: 1054 GCLQCSHR--DRCHLCDHGFF--LKSGLCVYNCVPGFSVHTSNETC 1095
GC CS R +C C GF+ + CV C GF S + C
Sbjct: 739 GCETCSSRAATQCLSCRRGFYHHQEMNTCVTLCPAGFYADESQKNC 784
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 110 bits (276), Expect = 2e-23
Identities = 197/797 (24%), Positives = 251/797 (31%), Gaps = 205/797 (25%)
Query: 408 VKGQCC-PDCTSVHCHP-----DCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQA 461
V G+C PD + HC P DC + S C + + C G A
Sbjct: 108 VHGRCVSPD--TCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAA 165
Query: 462 GSLCLACQPQCSTCTSGLECSSCQPPLLMRHG-QCVPTCGDGFYQDRHSCAVCHESCAGC 520
G C+ C+ T G CQ P RHG C P G+ ++ C E C
Sbjct: 166 GFRGWRCEELCAPGTHG---KGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELC--- 219
Query: 521 WGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCLTCTE 580
P H C G C G+ T + C Q C P C++
Sbjct: 220 --PPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPC----PPGTFGQNCSQ 273
Query: 581 KTVLHDG-------------------KCMSECPGGYYADATGRCKVCHNSCASCSGPTPS 621
H G +C ECP G + + CHN CS PT
Sbjct: 274 DCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNG-GQCS-PTTG 331
Query: 622 HCTACSPPKALRQGHCLPRCGEGFYSD--HGV-----CKACHSSCLACMGPAPSHCTGCK 674
C C P G+ PRC E + HG C + ++C P CT C+
Sbjct: 332 ACE-CEP------GYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCH-PVTGACT-CQ 382
Query: 675 KPEEGLQVEQLSDVGIPSGECLAQCRAHFYLES---TGIC--------EACHQSCFRCAG 723
G + VG C C + TG C E C SC AG
Sbjct: 383 PGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSC--AAG 440
Query: 724 KSPHNCTD---------CGPSHVLLDGQCLSQCPDGYFHQEGSCT----------ECHPT 764
NC+ C P +DG C C +G+ Q CT C+ +
Sbjct: 441 TYGPNCSSICSCNNGGTCSP----VDGSCT--CKEGW--QGLDCTLPCPSGTWGLNCNES 492
Query: 765 CRQCHG----PLESDCISCYPHISLTNGNCRTSCREEQF-LNLVGYCADCHH------LC 813
C +G P++ C SC P C C + F LN +C DC H +
Sbjct: 493 CTCANGAACSPIDGSC-SCTP--GWLGDTCELPCPDGTFGLNCSEHC-DCSHADGCDPVT 548
Query: 814 QHCAADLHNTGSIC-LRCQNAHYLLLGDHCVPDCPSGYYAERGACKKCHSSCRTCQG-RG 871
HC TG C C + G +C C G+C SC G RG
Sbjct: 549 GHCCCLAGWTGIRCDSTCPPGRW---GPNCSVSCSC---ENGGSCSPEDGSCECAPGFRG 602
Query: 872 PFSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHVC-----------QPCNTHCGSCDSQA 920
P C C PG Y H C +PC+ G C+
Sbjct: 603 PL----------------CQRICPPGFY---GHGCAQPCPLCVHSSRPCHHISGICECLP 643
Query: 921 SCTS--CRDPNKVLLFGE--CQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDCLQ- 975
+ C FG+ Q SCA + TC D SC G + DC Q
Sbjct: 644 GFSGALCNQVCAGGYFGQDCAQLCSCA-------NNGTCSPIDGSCQCFPGWIGKDCSQA 696
Query: 976 CMDGYVLQDGACVEQCL----SSFYQDSGLCKCDS-----YCLQCQGPHECTRCKGPFLL 1026
C G+ AC C +S + G C C +C Q RC F
Sbjct: 697 CPPGF--WGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQ--------RCPAAFFG 746
Query: 1027 LEAQCVQECGKGYFADHAKHKCTA--------CPQ---------GCLQCSHRDRCHLCDH 1069
+ V +C G DH KCT C Q GC Q CDH
Sbjct: 747 KDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDH 806
Query: 1070 GFFLKSGLCVYNCVPGF 1086
+G C C PGF
Sbjct: 807 ----VTGTCY--CSPGF 817
Score = 91.7 bits (226), Expect = 1e-17
Identities = 163/694 (23%), Positives = 215/694 (30%), Gaps = 175/694 (25%)
Query: 454 CGLGFYQAGSLCLA-CQPQC--STCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDR--- 507
C G+Y++G C+ C +C C S C C+P G P C G D
Sbjct: 88 CCPGYYESGDFCIPLCTEECVHGRCVSPDTCH-CEP------GWGGPDCSSGCDSDHWGP 140
Query: 508 HSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCD- 566
H C P C+ R CE C G + + C C
Sbjct: 141 HCSNRCQCQNGALCNPITGACVCAAG----FRGWRCEELCAPGTHGK-----GCQLPCQC 191
Query: 567 ----SCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSH 622
SC P + CL T ++ C CP G + C C +G T H
Sbjct: 192 RHGASCDPRAGECLCAPGYTGVY---CEELCPPGSHGAH------CELRCPCQNGGTCHH 242
Query: 623 CTA-CSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQ 681
T C+ P C C G + + C C G H TG G
Sbjct: 243 ITGECACPPGWTGAVCAQPCPPGTFGQN-----CSQDCPCHHGGQCDHVTGQCHCTAGYM 297
Query: 682 VEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDG 741
++ + P G QC H + G C +C +C P +
Sbjct: 298 GDRCQEE-CPFGSFGFQCSQHCDCHNGGQCSPTTGAC------------ECEPGYK--GP 342
Query: 742 QCLSQ-CPDGYFHQEGSCTECHPTCRQCHGPLESD-CISCYPHISLTNGNCRTSCREEQF 799
+C + CP+G H G C P ++D ISC+P
Sbjct: 343 RCQERLCPEG-LHGPGCTLPC---------PCDADNTISCHP------------------ 374
Query: 800 LNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYY-------- 851
+ G C CQ G HC CP GYY
Sbjct: 375 --VTGACT----------------------CQPGWS---GHHCNESCPVGYYGDGCQLPC 407
Query: 852 -AERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTG-TCSTTCFPGHYLDDNHVCQPC 909
+ GA CHS C F C + G CS+ C ++ C P
Sbjct: 408 TCQNGA--DCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSIC----SCNNGGTCSPV 461
Query: 910 NTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDWSCSACSGPL 969
+ C +C C P +G ESC + C D SCS G L
Sbjct: 462 DGSC-TCKEGWQGLDCTLPCPSGTWGLNCNESCTCA-----NGAACSPIDGSCSCTPGWL 515
Query: 970 KTDC-LQCMDGYVLQDGACVEQCLSSFYQD----SGLC---------KCDSYCLQCQ-GP 1014
C L C DG + C E C S +G C +CDS C + GP
Sbjct: 516 GDTCELPCPDGTFGLN--CSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGP 573
Query: 1015 HECTRCK----GPFLLLEAQCVQECGKGYFADHAKHKCT------ACPQGCLQCSHRDR- 1063
+ C G + C EC G+ + C C Q C C H R
Sbjct: 574 NCSVSCSCENGGSCSPEDGSC--ECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRP 631
Query: 1064 CHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCSG 1097
CH SG+C C+PGFS N+ C+G
Sbjct: 632 CHHI-------SGIC--ECLPGFSGALCNQVCAG 656
Score = 81.3 bits (199), Expect = 2e-14
Identities = 198/796 (24%), Positives = 246/796 (30%), Gaps = 224/796 (28%)
Query: 26 GACVYQ--------DSLLADATIWKPDSCQ-SCRC-HGDIVICKPAVCRNPQCAFEKGEV 75
GACV + L A T K CQ C+C HG C P R +C G
Sbjct: 159 GACVCAAGFRGWRCEELCAPGTHGK--GCQLPCQCRHG--ASCDP---RAGECLCAPGYT 211
Query: 76 LQIAANQCCP-----ECVLRTP----GSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCT 126
C P C LR P G+CHH W + C+
Sbjct: 212 GVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCA------------ 259
Query: 127 PQPCPPLSCGH---QELAFIPEGSC------CPVCVG-LGKPCSYEGHVFQDGEDWRLSR 176
QPCPP + G Q+ G C C G +G C E G +
Sbjct: 260 -QPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFG-----FQ 313
Query: 177 CAK-CLCRNGVAQCFTAQCQPLF--CNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQ 233
C++ C C NG QC P C + PG P+C R C HG
Sbjct: 314 CSQHCDCHNG------GQCSPTTGACECE------PGYKGPRCQERLCPEG----LHGP- 356
Query: 234 WSENACTT-CICDRGE-VRCHKQ--ACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDG 289
CT C CD + CH AC C G S C E C P G
Sbjct: 357 ----GCTLPCPCDADNTISCHPVTGACT---CQPGWSGHH----CNESC--PVG------ 397
Query: 290 VVRYQDEMWKGSACEF-CMCDHGQ--------VTCQTG---ECAKVECARDEELIHLDGK 337
+ G C+ C C +G TC G E V CA G
Sbjct: 398 --------YYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAA--------GT 441
Query: 338 CCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCP 397
P C S C G + S + E W+ C +
Sbjct: 442 YGPNCSS---ICSCNNGGTCSPVDGSCTCK----EGWQGLDCTL---------------- 478
Query: 398 PCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSP----DHCDL-CQDPTKLL---QNGW 449
PCP GT L + C C P +CS +P D C+L C D T L ++
Sbjct: 479 PCPSGTWGLNCN-ESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCD 537
Query: 450 CVHSCGLGFYQAGSLCLA------CQ---------PQCS---TCTSGLECS----SCQPP 487
C H+ G CLA C P CS +C +G CS SC+
Sbjct: 538 CSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECA 597
Query: 488 LLMRHGQCVPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSC 547
R C C GFY H CA C P H + L C C
Sbjct: 598 PGFRGPLCQRICPPGFYG--HGCAQPCPLCVHSSRPCH-HISGICECLPGFSGALCNQVC 654
Query: 548 GKGFYNRQ----------GTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGY 597
G++ + GTCS D SC C + D C CP G+
Sbjct: 655 AGGYFGQDCAQLCSCANNGTCSPIDGSCQ-----------CFPGWIGKD--CSQACPPGF 701
Query: 598 YADATGRCKVCHNSCASCSGPTPS-HCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACH 656
+ A CHN ASCS + HCT C RC F+ K C
Sbjct: 702 WGPACFHACSCHNG-ASCSAEDGACHCT-----PGWTGLFCTQRCPAAFFG-----KDCG 750
Query: 657 SSCLACMGPAPSHCTG---CKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEA 713
C G + H +G C+ G EQ G C C + C+
Sbjct: 751 RVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCEC----MNNSTCDH 806
Query: 714 CHQSCFRCAGKSPHNC 729
+C+ G C
Sbjct: 807 VTGTCYCSPGFKGIRC 822
>gi|30089980 chordin [Homo sapiens]
Length = 955
Score = 107 bits (266), Expect = 3e-22
Identities = 78/246 (31%), Positives = 93/246 (37%), Gaps = 66/246 (26%)
Query: 90 RTPGSCHHEKKIHEHGTEWASSP---CSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEG 146
R P +C E + HG WA + CS+C+C V C P CPP SC H A
Sbjct: 700 RDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQA---PD 756
Query: 147 SCCPVCVGL-------GKPCSY---EGHVFQDGEDWR--------------LSRCAKCLC 182
CCPVC G P S EG F WR L +CA C C
Sbjct: 757 QCCPVCPEKQDVRDLPGLPRSRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTC 816
Query: 183 RNGVAQ--CFTAQCQPLFCNQDETVVRV-PGKCCPQC-----------------SARSCS 222
+ G + C QC L C Q VRV P CC QC R C
Sbjct: 817 KGGTGEVHCEKVQCPRLACAQP---VRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRGCR 873
Query: 223 AAGQVYEHGEQW-------SENACTTCICDRGEVRCHKQAC-LPLRCGKGQSRARRHGQC 274
AGQ + + W E +C TC C G C + C LPL CG G + +C
Sbjct: 874 FAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGSG-----KESRC 928
Query: 275 CEECVS 280
C C +
Sbjct: 929 CSRCTA 934
Score = 79.7 bits (195), Expect = 5e-14
Identities = 68/241 (28%), Positives = 86/241 (35%), Gaps = 61/241 (25%)
Query: 28 CVYQDSLLADATIWKPDS---CQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCC 84
C ++ W P+ C C C VIC P VC P C A +QCC
Sbjct: 705 CFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQ-----APDQCC 759
Query: 85 PECV-------------LRTPG-SCHH--EKKIHEHGTEW-------ASSPCSVCSC--N 119
P C R PG C+ ++ GT W C+VC+C
Sbjct: 760 PVCPEKQDVRDLPGLPRSRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGG 819
Query: 120 HGEVRCTPQPCPPLSCGHQELAFIPEGSC--CPVCVG----LGKP--------CSYEGHV 165
GEV C CP L+C Q + P C CPV G LG P C + G
Sbjct: 820 TGEVHCEKVQCPRLACA-QPVRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRGCRFAGQW 878
Query: 166 FQDGEDWRLS-------RCAKCLCRNGVAQCFTAQCQ-PLFCNQDETVVRVPGKCCPQCS 217
F + + W S C C C GV C C PL C + +CC +C+
Sbjct: 879 FPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGSGK-----ESRCCSRCT 933
Query: 218 A 218
A
Sbjct: 934 A 934
Score = 65.5 bits (158), Expect = 1e-09
Identities = 57/246 (23%), Positives = 85/246 (34%), Gaps = 62/246 (25%)
Query: 220 SCSAAGQVYEHGEQWSEN---ACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCE 276
+C GQ HG +W+ N C+ C C R V C C P C + QCC
Sbjct: 704 TCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSC---PHPVQAPDQCCP 760
Query: 277 ECVS---------------PAGSCSYDGVVRYQDEMWKGSA--------------CEFCM 307
C P C +DG D W+ + C C
Sbjct: 761 VCPEKQDVRDLPGLPRSRDPGEGCYFDG-----DRSWRAAGTRWHPVVPPFGLIKCAVCT 815
Query: 308 CDHG--QVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEV 365
C G +V C+ +C ++ CA+ + D CC +C +G + + G+ M ++
Sbjct: 816 CKGGTGEVHCEKVQCPRLACAQPVRVNPTD--CCKQCPVGSG--AHPQLGDPMQADGPRG 871
Query: 366 KR-----IPEGEKWE-------DGPCKVCECRGAQVTCYEPSCP-PCPVGTLALEVKGQC 412
R PE + W + C C C C C P G+ + +C
Sbjct: 872 CRFAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGS---GKESRC 928
Query: 413 CPDCTS 418
C CT+
Sbjct: 929 CSRCTA 934
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 102 bits (255), Expect = 6e-21
Identities = 217/896 (24%), Positives = 281/896 (31%), Gaps = 219/896 (24%)
Query: 69 AFEKGE-VLQIAANQCCPE-------CVLRTPGSCHHEKKIHEHGTE----WASSPCS-V 115
A+ GE + +QCCP CV C H + I + + W + CS
Sbjct: 79 AYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSA 138
Query: 116 CSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLS 175
C +H CT + C + L G+C G C G D
Sbjct: 139 CDGDHWGPHCTSR----CQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCH-- 192
Query: 176 RCAKCLCRNGVAQCF----TAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHG 231
+C C+NG A C +C P + + PGK PQC R G V H
Sbjct: 193 --QRCQCQNG-ATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHH- 248
Query: 232 EQWSENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEEC-VSPAGSCSYDGV 290
C C G + CG+ R C +EC G+C
Sbjct: 249 ------VTGECSCPSG--------WMGTVCGQPCPEGRFGKNCSQECQCHNGGTCD---- 290
Query: 291 VRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPE-CISRNGYC 349
+A C C G TGE + EC + G C E C NG
Sbjct: 291 ----------AATGQCHCSPGY----TGERCQDECP-----VGTYGVLCAETCQCVNGGK 331
Query: 350 VYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVK 409
Y +G + +R CE R CP G ++
Sbjct: 332 CYHVSGACLCEAGFAGER--------------CEAR------------LCPEGLYGIKCD 365
Query: 410 GQCCPDCTSVH-CHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGSLCLAC 468
+C + H CHP C+ P L +C +C GFY AC
Sbjct: 366 KRCPCHLENTHSCHPMSGECACKPGWSGL-----------YCNETCSPGFYGE-----AC 409
Query: 469 QPQCSTCTSGLECSSCQPPLLMRHG----QCVPTCGDGFYQDRHSCAVCHESCAGCWGPT 524
Q CS C +G +C S G C C G Y S ++ A C P
Sbjct: 410 QQICS-CQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVC-SPV 467
Query: 525 EKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCL--TCTEKT 582
+ C C+ H + C C G + C+ +C + L TCT
Sbjct: 468 DGSC-TCKAGWHGV---DCSIRCPSGTWG-----FGCNLTCQCLNGGACNTLDGTCTCAP 518
Query: 583 VLHDGKCMSECPGGYYA-DATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRC 641
KC C G Y + RC H A PT HC C P HC C
Sbjct: 519 GWRGEKCELPCQDGTYGLNCAERCDCSH---ADGCHPTTGHCR-CLP--GWSGVHCDSVC 572
Query: 642 GEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRA 701
EG + + C C G + S P++G+ G C C
Sbjct: 573 AEGRWGPN-----CSLPCYCKNGASCS-------PDDGICE---CAPGFRGTTCQRICSP 617
Query: 702 HFYLESTGICEACHQSCFRCAGKSP--HNCT---DCGPSHVLLDGQCLSQCPDGYFHQE- 755
FY C Q+C +C S H+ T DC P C CP G F +
Sbjct: 618 GFY------GHRCSQTCPQCVHSSGPCHHITGLCDCLPGFT--GALCNEVCPSGRFGKNC 669
Query: 756 -GSCT-----ECHPTCRQCH---GPLESDCI--------------SCYPH----ISLTNG 788
G CT C+P R C G + SDC +C H S +G
Sbjct: 670 AGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG 729
Query: 789 NCR-----TSCREEQFLNLVGYCADCHHLCQ-HCAADLHNTGSICLRCQNAHYLLLGDHC 842
C+ T Q L Y DC +CQ AD + C C+ +G HC
Sbjct: 730 ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCT-CRTG---FMGRHC 785
Query: 843 VPDCPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSH-TGTCSTTCFPG 897
CPSG Y G G C N H TGTC C PG
Sbjct: 786 EQKCPSGTY-----------------GYGCRQICDCLNNSTCDHITGTC--YCSPG 822
Score = 97.1 bits (240), Expect = 3e-19
Identities = 155/622 (24%), Positives = 206/622 (33%), Gaps = 126/622 (20%)
Query: 544 ESSCGKGFYNRQGTCSACDQSCDSCGPSSPRCL---TCTEKTVLHDGKCMSECPGGYYAD 600
+S C GFY C D C RC+ TC + C S C G ++
Sbjct: 91 KSQCCPGFYESGEMC--VPHCADKCVHG--RCIAPNTCQCEPGWGGTNCSSACDGDHWGP 146
Query: 601 -ATGRCKVCHNSCASCSGPTPS-HCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSS 658
T RC+ C N A C+ T + HC A R C RC +G Y + CH
Sbjct: 147 HCTSRCQ-CKNG-ALCNPITGACHCAA-----GFRGWRCEDRCEQGTYGND-----CHQR 194
Query: 659 CLACMGPAPSHCTG---CKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACH 715
C G H TG C G E L P G+ QC ++ G+C H
Sbjct: 195 CQCQNGATCDHVTGECRCPPGYTGAFCEDLC----PPGKHGPQCEQRCPCQNGGVC---H 247
Query: 716 QSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCH--GPLE 773
C+ S T CG CP+G F + C C QCH G +
Sbjct: 248 HVTGECSCPSGWMGTVCG-----------QPCPEGRFGKN-----CSQEC-QCHNGGTCD 290
Query: 774 SDCISCYPHISLTNGNCRTSCREEQFLNLVG-YCADCHHLCQHC-AADLHNTGSICLRCQ 831
+ C+ T C+ C VG Y C CQ ++ CL C+
Sbjct: 291 AATGQCHCSPGYTGERCQDECP-------VGTYGVLCAETCQCVNGGKCYHVSGACL-CE 342
Query: 832 NAHYLLLGDHCVPD-CPSGYYAERGACKKCHSSCRTCQGRGPFSCSSCDTNLVLSHTGT- 889
G+ C CP G Y KC C C SC +
Sbjct: 343 AG---FAGERCEARLCPEGLYGI-----KCDKRC-PCHLENTHSCHPMSGECACKPGWSG 393
Query: 890 --CSTTCFPGHYLDDNHVCQP-CNTHCGS-CDSQASCTSCRDPNKVLLFGECQYESCAPQ 945
C+ TC PG Y CQ C+ G+ CDS +C K + +C
Sbjct: 394 LYCNETCSPGFY---GEACQQICSCQNGADCDSVTGKCTCAPGFKGI---DCSTPCPLGT 447
Query: 946 YYLDFSTN-------TCKECDWSCSACSGPLKTDC----------------LQCMDGYVL 982
Y ++ S+ C D SC+ +G DC QC++G
Sbjct: 448 YGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGAC 507
Query: 983 Q--DGACV-----------EQCLSSFYQDSGLCKCDSYCLQCQGPHECT-RCKGPFLLLE 1028
DG C C Y + +CD C G H T C+
Sbjct: 508 NTLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCD--CSHADGCHPTTGHCRCLPGWSG 565
Query: 1029 AQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFSV 1088
C C +G + + C C G CS D C GF + C C PGF
Sbjct: 566 VHCDSVCAEGRWGPNCSLPCY-CKNGA-SCSPDDGICECAPGF--RGTTCQRICSPGFYG 621
Query: 1089 HTSNETCSGKIHT--PSLHVNG 1108
H ++TC +H+ P H+ G
Sbjct: 622 HRCSQTCPQCVHSSGPCHHITG 643
Score = 92.0 bits (227), Expect = 1e-17
Identities = 164/687 (23%), Positives = 218/687 (31%), Gaps = 165/687 (24%)
Query: 454 CGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVP--TCGDGFYQDRHSCA 511
C GFY++G +C+ P C+ +C HG+C+ TC
Sbjct: 94 CCPGFYESGEMCV---PHCAD-----KCV---------HGRCIAPNTC------------ 124
Query: 512 VCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGTCSACDQSCDSCGPS 571
C WG T C S+C + T S C C +
Sbjct: 125 ----QCEPGWGGT-----------------NCSSACDGDHWGPHCT-SRC--QCKNGALC 160
Query: 572 SPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTA-CSPPK 630
+P C +C C G Y + CH C +G T H T C P
Sbjct: 161 NPITGACHCAAGFRGWRCEDRCEQGTYGND------CHQRCQCQNGATCDHVTGECRCPP 214
Query: 631 ALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTG---CKKPEEGLQVEQLSD 687
C C G HG C C G H TG C G Q
Sbjct: 215 GYTGAFCEDLCPPG---KHG--PQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCP 269
Query: 688 VGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTD---CGPSHVLLDGQCL 744
G C +C+ H + G C+A C G + C D G VL C
Sbjct: 270 EGRFGKNCSQECQCH----NGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETC- 324
Query: 745 SQCPDG--YFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNL 802
QC +G +H G+C C + C + + R C E
Sbjct: 325 -QCVNGGKCYHVSGAC-----LCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLEN---- 374
Query: 803 VGYCADCHHLCQHCAADLHNTGSICLR-CQNAHYLLLGDHCVPDCPSGYYAERGACKKCH 861
CH + CA +G C C Y G+ C C + GA C
Sbjct: 375 ---THSCHPMSGECACKPGWSGLYCNETCSPGFY---GEACQQICS----CQNGA--DCD 422
Query: 862 SSCRTCQGRGPFSCSSCDTNLVLSHTG-TCSTTCFPGHYLDDNHVCQPCNTHCGSCDSQA 920
S C F C T L G CS+ C ++ VC P + GSC +A
Sbjct: 423 SVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRC----GCKNDAVCSPVD---GSCTCKA 475
Query: 921 SC----TSCRDPNKVLLFG---ECQYESCAPQYYLDFSTNTCKECDWSCSACSGPLKTDC 973
S R P+ FG CQ + C D +C+ G C
Sbjct: 476 GWHGVDCSIRCPSGTWGFGCNLTCQC----------LNGGACNTLDGTCTCAPGWRGEKC 525
Query: 974 -LQCMDG-YVLQDGACVEQCLSSF----YQDSGLCK---------CDSYCLQCQGPHECT 1018
L C DG Y L C E+C S + +G C+ CDS C + + C+
Sbjct: 526 ELPCQDGTYGLN---CAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCS 582
Query: 1019 ---RCKGPFLLLEAQCVQECGKGYFADHAKHKCT------ACPQGCLQCSHRD-RCHLCD 1068
CK + EC G+ + C+ C Q C QC H CH
Sbjct: 583 LPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHI- 641
Query: 1069 HGFFLKSGLCVYNCVPGFSVHTSNETC 1095
+GLC +C+PGF+ NE C
Sbjct: 642 ------TGLC--DCLPGFTGALCNEVC 660
Score = 91.3 bits (225), Expect = 2e-17
Identities = 195/813 (23%), Positives = 243/813 (29%), Gaps = 188/813 (23%)
Query: 374 WEDGPCKVCECRGAQV--TCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQS 431
+E G V C V C P+ C G C D HC C C
Sbjct: 99 YESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCTSRC-QCKNG 157
Query: 432 PDHCDLCQDPTKLLQ-----NGW-CVHSCGLGFYQAGSLCLACQPQCSTCTSGLECS--- 482
LC T GW C C G Y C +C C +G C
Sbjct: 158 A----LCNPITGACHCAAGFRGWRCEDRCEQGTYGND-----CHQRCQ-CQNGATCDHVT 207
Query: 483 -SCQPPLLMRHGQCVPTCGDGFY----QDRHSC---AVCHESCAGCWGPTEKHCLACRDP 534
C+ P C C G + + R C VCH C P+ C P
Sbjct: 208 GECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQP 267
Query: 535 LHVLRDG-GCESSCGKGFYNRQGTCSACDQSCD-SCGPSSPRC----------LTCTE-- 580
R G C C + GTC A C S G + RC + C E
Sbjct: 268 CPEGRFGKNCSQECQ---CHNGGTCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAETC 324
Query: 581 ------KTVLHDGKCMSE------------CPGGYYADATGRCKVCHNSCASCSGPTPSH 622
K G C+ E CP G Y + CH P
Sbjct: 325 QCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSGE 384
Query: 623 CTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTG---CKKPEEG 679
C AC P +C C GFY + AC C G TG C +G
Sbjct: 385 C-ACKP--GWSGLYCNETCSPGFYGE-----ACQQICSCQNGADCDSVTGKCTCAPGFKG 436
Query: 680 LQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCGPSHVLL 739
+ +G C ++C ++ +C SC AG +C+ PS
Sbjct: 437 IDCSTPCPLGTYGINCSSRCGC----KNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWG 492
Query: 740 DGQCLS-QCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQ 798
G L+ QC +G G+C TC +C P C C++
Sbjct: 493 FGCNLTCQCLNG-----GACNTLDGTC------------TCAP--GWRGEKCELPCQDGT 533
Query: 799 F-LNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPDCPSGYYAERGAC 857
+ LN C DC H A H T C RC G HC C G +
Sbjct: 534 YGLNCAERC-DCSH-----ADGCHPTTGHC-RCLPGWS---GVHCDSVCAEGRWGPN--- 580
Query: 858 KKCHSSCRTCQGRGPFSCSSCDTNLVLSHTG----TCSTTCFPGHYLDDNHVCQ------ 907
C C G SCS D + G TC C PG Y H C
Sbjct: 581 --CSLPCYCKNGA---SCSP-DDGICECAPGFRGTTCQRICSPGFY---GHRCSQTCPQC 631
Query: 908 -----PCNTHCGSCDSQASCTS--CRDPNKVLLFGECQYESCAPQYYLDFSTNTCKECDW 960
PC+ G CD T C + FG+ C + TC D
Sbjct: 632 VHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCT-----NNGTCNPIDR 686
Query: 961 SCSACSGPLKTDCLQ-CMDGY----VLQDGACVEQCLSSFYQDSGLCKCDS-----YCLQ 1010
SC G + +DC Q C + + C S Y G CKC YC Q
Sbjct: 687 SCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAY--DGECKCTPGWTGLYCTQ 744
Query: 1011 CQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTA------------CPQGCLQC 1058
RC F + + +C G DH +CT CP G
Sbjct: 745 --------RCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGY 796
Query: 1059 SHRDRC-----HLCDHGFFLKSGLCVYNCVPGF 1086
R C CDH +G C C PG+
Sbjct: 797 GCRQICDCLNNSTCDH----ITGTCY--CSPGW 823
Score = 83.6 bits (205), Expect = 4e-15
Identities = 161/706 (22%), Positives = 217/706 (30%), Gaps = 160/706 (22%)
Query: 82 QCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
QC C + G CHH + W + C QPC
Sbjct: 233 QCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCG-------------QPC----------- 268
Query: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRN-GVAQCFTAQCQPLFCN 200
PEG GK CS E C C N G T QC C+
Sbjct: 269 --PEGR-------FGKNCSQE-----------------CQCHNGGTCDAATGQCH---CS 299
Query: 201 QDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGEV--RCHKQAC-- 256
T R +C C+ Q G+ + + C+C+ G RC + C
Sbjct: 300 PGYTGERCQDECPVGTYGVLCAETCQCVNGGKCY--HVSGACLCEAGFAGERCEARLCPE 357
Query: 257 --LPLRCGKGQSRARRHGQCCEECVSPAGSCS----YDGVVRYQDEM----WKGSAC-EF 305
++C K R H + C +G C+ + G+ Y +E + G AC +
Sbjct: 358 GLYGIKCDK---RCPCHLENTHSCHPMSGECACKPGWSGL--YCNETCSPGFYGEACQQI 412
Query: 306 CMCDHG-QVTCQTGECA------KVECARDEELIHLDGKCCPECISRN--------GYCV 350
C C +G TG+C ++C+ L C C +N G C
Sbjct: 413 CSCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCT 472
Query: 351 YEETGEFMSSNASEVKRIPEGEKWEDGPCKVCEC-RGAQVTCYEPSCP------------ 397
+ + + R P G W G C+C G + +C
Sbjct: 473 CKAGWHGVDCSI----RCPSG-TWGFGCNLTCQCLNGGACNTLDGTCTCAPGWRGEKCEL 527
Query: 398 PCPVGTLALEVKGQCCPDCTSVH-CHPDCLTCSQSPD----HCDLCQDPTKLLQNGWCVH 452
PC GT L +C DC+ CHP C P HCD + G
Sbjct: 528 PCQDGTYGLNCAERC--DCSHADGCHPTTGHCRCLPGWSGVHCD------SVCAEGRWGP 579
Query: 453 SCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAV 512
+C L Y +C P C C P R C C GFY H C+
Sbjct: 580 NCSLPCYCKNG--ASCSPDDGIC-------ECAPG--FRGTTCQRICSPGFY--GHRCSQ 626
Query: 513 CHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFY--NRQGTCSACDQSCDSCGP 570
C GP H D L C C G + N G C+ + +C P
Sbjct: 627 TCPQCVHSSGPCH-HITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNG--TCNP 683
Query: 571 SSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPK 630
C C + D C CP ++ CHN A CS ++ C
Sbjct: 684 IDRSC-QCYPGWIGSD--CSQPCPPAHWGPNCIHTCNCHNG-AFCS----AYDGECKCTP 735
Query: 631 ALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTG---CKKPEEGLQVEQLSD 687
+C RC GFY K C C G H +G C+ G EQ
Sbjct: 736 GWTGLYCTQRCPLGFYG-----KDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQ--- 787
Query: 688 VGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAGKSPHNCTDCG 733
PSG CR + C+ +C+ G C G
Sbjct: 788 -KCPSGTYGYGCRQICDCLNNSTCDHITGTCYCSPGWKGARCDQAG 832
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 94.0 bits (232), Expect = 3e-18
Identities = 129/539 (23%), Positives = 192/539 (35%), Gaps = 119/539 (22%)
Query: 23 HSEGACVYQDSLLADATIWKP-DSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAAN 81
H E C L D W D C++C C V C+ C C+ + V A
Sbjct: 268 HCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPV--HIAG 325
Query: 82 QCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
QCC C C + K+ G + C C G + + CPPL+C ++
Sbjct: 326 QCCKVC----RPKCIYGGKVLAEGQRILTKSCR--ECRGGVLVKITEMCPPLNCSEKD-H 378
Query: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGV--AQCFTAQCQPL-- 197
+PE CC VC G C+ ++ E + A C C++G Q +A C+ +
Sbjct: 379 ILPENQCCRVCRG-HNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDE 437
Query: 198 ------FCNQDETVVRVPG----KCCP---QCSARSCSAAGQVYEHGEQWSENACTTCIC 244
+C+ + V +PG C P + SC+ + ENA T
Sbjct: 438 CAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICT--- 494
Query: 245 DRGEVRCHKQACLPLRCGKGQ------SRARRHGQCC---EECVSPAG-----------S 284
V+ H C P G G R+G C +CV P+G
Sbjct: 495 --NTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDE 552
Query: 285 CSYDGVVRYQDEM-------WKGSACEFCMCDHGQVTCQTGECAKVE--------CARDE 329
CS +G++ + W C D G + C ++ C D
Sbjct: 553 CS-EGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDS 611
Query: 330 ELIHLDGK---CCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW--EDGPCKVCEC 384
I+L G CP S +G C +E +K G+ W ++ C VC C
Sbjct: 612 ACINLAGGFDCLCPSGPSCSGDCPHE----------GGLKH--NGQVWTLKEDRCSVCSC 659
Query: 385 RGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKL 444
+ ++ C +C C + L CCP+C D SQ D Q+ KL
Sbjct: 660 KDGKIFCRRTAC-DCQNPSADL----FCCPEC-------DTRVTSQCLD-----QNGHKL 702
Query: 445 LQNG--WCVHSCGLGFYQAGSLCLACQPQC--STCTSGLECSSCQPPLLMRHGQCVPTC 499
++G W HSC CL + C TC + SC+ ++ G+C P C
Sbjct: 703 YRSGDNW-THSC------QQCRCLEGEVDCWPLTCPN----LSCEYTAIL-EGECCPRC 749
Score = 91.3 bits (225), Expect = 2e-17
Identities = 145/618 (23%), Positives = 191/618 (30%), Gaps = 128/618 (20%)
Query: 94 SCHHEKKIHEHGT------EWASSP-CSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEG 146
+CH EK G W C C+C G V C CPPL+C L G
Sbjct: 266 NCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAG 325
Query: 147 SCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVV 206
CC VC C Y G V +G+ C + CR GV T C PL C++ + ++
Sbjct: 326 QCCKVC---RPKCIYGGKVLAEGQRILTKSCRE--CRGGVLVKITEMCPPLNCSEKDHIL 380
Query: 207 RVPGKCCPQCSARS-CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCGKGQ 265
+CC C + C+ + E+ E + N TC C G + + C
Sbjct: 381 -PENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAY---CEDID 436
Query: 266 SRARRHGQCCEE--CVSPAGSCSYD---GVVRYQDEMWKGSACEFCMCDHGQVTCQTGEC 320
A + C CV+ G D G +R D S E C GQ C
Sbjct: 437 ECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDD----FSCTEHDECGSGQHNC----- 487
Query: 321 AKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCK 380
DE I + C + GY N + + E +
Sbjct: 488 -------DENAICTNTVQGHSCTCKPGYV----------GNGTICRAFCE---------E 521
Query: 381 VCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQD 440
C G TC P+ CP G T HC D CS+ C
Sbjct: 522 GCRYGG---TCVAPNKCVCPSG-------------FTGSHCEKDIDECSEGIIECHNHSR 565
Query: 441 PTKLLQNGWCVHSCGLGFYQAGSLCLA---------CQPQCSTCTSGLECSSCQPPLLMR 491
L GW C GF+ G+ L+ C + TC + C + L
Sbjct: 566 CVNL--PGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACIN-----LAG 618
Query: 492 HGQCVPTCGDGFYQD-RHSCAVCHESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKG 550
C+ G D H + H W E C C C+ GK
Sbjct: 619 GFDCLCPSGPSCSGDCPHEGGLKHN--GQVWTLKEDRCSVC----------SCKD--GKI 664
Query: 551 FYNRQGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHN 610
F R +ACD C S C E +C+ + Y C
Sbjct: 665 FCRR----TACD-----CQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSC-Q 714
Query: 611 SCASCSGPT---PSHCTACS-PPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMG-- 664
C G P C S A+ +G C PRC + +CL G
Sbjct: 715 QCRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVS 774
Query: 665 --------PAPSHCTGCK 674
A S CT CK
Sbjct: 775 RLSGSVWTMAGSPCTTCK 792
Score = 88.6 bits (218), Expect = 1e-16
Identities = 56/184 (30%), Positives = 71/184 (38%), Gaps = 35/184 (19%)
Query: 26 GACVYQDSLLADATIW--KPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQC 83
G C ++ L + +W K D C C C + C+ C C ++ C
Sbjct: 632 GDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADLF------C 682
Query: 84 CPECVLRTPGSCHHEK--KIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELA 141
CPEC R C + K++ G W S C C C GEV C P CP LSC E
Sbjct: 683 CPECDTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSC---EYT 738
Query: 142 FIPEGSCCPVCVGLGKPCSYEGHVFQ--------------DGEDWRL--SRCAKCLCRNG 185
I EG CCP CV PC + + G W + S C C C+NG
Sbjct: 739 AILEGECCPRCV--SDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNG 796
Query: 186 VAQC 189
C
Sbjct: 797 RVCC 800
Score = 80.5 bits (197), Expect = 3e-14
Identities = 53/180 (29%), Positives = 73/180 (40%), Gaps = 32/180 (17%)
Query: 93 GSCHHEKKIHEHGTEWA--SSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCP 150
G C HE + +G W CSVCSC G++ C C C + CCP
Sbjct: 632 GDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADLF----CCP 684
Query: 151 VC-VGLGKPC-SYEGH-VFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVR 207
C + C GH +++ G++W S C +C C G C+ C L C E
Sbjct: 685 ECDTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSC---EYTAI 740
Query: 208 VPGKCCPQCSARSCSAAGQVYE--------------HGEQW--SENACTTCICDRGEVRC 251
+ G+CCP+C + C A Y+ G W + + CTTC C G V C
Sbjct: 741 LEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCC 800
Score = 77.4 bits (189), Expect = 3e-13
Identities = 146/636 (22%), Positives = 208/636 (32%), Gaps = 144/636 (22%)
Query: 284 SCSYDGVV-RYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPEC 342
+C G++ R QD G C C C G V C+ C + C+ D +H+ G+CC C
Sbjct: 272 TCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQCCKVC 331
Query: 343 ISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVG 402
+ C+Y K + EG++ C+ ECRG + CPP
Sbjct: 332 RPK---CIYGG------------KVLAEGQRILTKSCR--ECRGGVLVKITEMCPP---- 370
Query: 403 TLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSC-GLGFYQA 461
L CS+ DH +L C C G F
Sbjct: 371 -----------------------LNCSEK-DH---------ILPENQCCRVCRGHNFCAE 397
Query: 462 GSLCLACQPQCSTCTSGLECSSCQPPLLMRHGQCVPTCGDGFYQDRHSCAV----CHES- 516
G C +C + C C+ + G + +D CA CH +
Sbjct: 398 GPKC-GENSECKNWNTKATC-ECKSGYISVQGD------SAYCEDIDECAAKMHYCHANT 449
Query: 517 -CAGCWGPTEKHCLACRDPLHV-LRDGGC--ESSCGKGFYNRQGTCSACDQSCDSCGPSS 572
C G C+ P ++ + D C CG G +N CD++
Sbjct: 450 VCVNLPGLYRCDCV----PGYIRVDDFSCTEHDECGSGQHN-------CDENAICTNTVQ 498
Query: 573 PRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHNSCASCSGPTPSHCTACSPPKAL 632
TC V + C + C G G C V N C SG T SHC
Sbjct: 499 GHSCTCKPGYVGNGTICRAFCEEG--CRYGGTC-VAPNKCVCPSGFTGSHCE-------- 547
Query: 633 RQGHCLPRCGEGFYSDHGVCKACHSSCLACMGPAPSHCTGCKKPEEGLQVEQLS-DVGIP 691
+ C EG H HS C+ P HC C+ LS + I
Sbjct: 548 ---KDIDECSEGIIECHN-----HSRCVNL--PGWYHCE-CRSGFHDDGTYSLSGESCID 596
Query: 692 SGECLAQCRAHF----YLESTGICEACHQSCFRCAGKSPH--NCTDCGPSHVLLDGQC-L 744
EC + + + G + S C+G PH G L + +C +
Sbjct: 597 IDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSV 656
Query: 745 SQCPDG-YFHQEGSCTECHPT-----CRQCHGPLESDCISCYPHISLTNG-NCRTSCREE 797
C DG F + +C +P+ C +C + S C+ H +G N SC++
Sbjct: 657 CSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQC 716
Query: 798 QFLNLVGYC--ADCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCVPD---------C 846
+ L C C +L A L G C RC + D C+ D C
Sbjct: 717 RCLEGEVDCWPLTCPNLSCEYTAILE--GECCPRC-------VSDPCLADNITYDIRKTC 767
Query: 847 PSGYYAER---GACKKCHSSCRTCQGRGPFSCSSCD 879
Y R S C TC+ + C S D
Sbjct: 768 LDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCSVD 803
Score = 69.7 bits (169), Expect = 6e-11
Identities = 53/188 (28%), Positives = 80/188 (42%), Gaps = 25/188 (13%)
Query: 214 PQCSARSCSAAGQVYEHGEQWS--ENACTTCICDRGEVRCHKQACLPLRCGKGQSRARRH 271
P CS C G + +G+ W+ E+ C+ C C G++ C + AC C +
Sbjct: 628 PSCSG-DCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTAC---DCQNPSADL--- 680
Query: 272 GQCCEECVSPAGSCSYD--GVVRYQD-EMWKGSACEFCMCDHGQVTCQTGECAKVECARD 328
CC EC + S D G Y+ + W S C+ C C G+V C C + C
Sbjct: 681 -FCCPECDTRVTSQCLDQNGHKLYRSGDNWTHS-CQQCRCLEGEVDCWPLTCPNLSC--- 735
Query: 329 EELIHLDGKCCPECISRNGYCVYEETGEFMSSNASE---VKRIPEGEKW--EDGPCKVCE 383
E L+G+CCP C+S C+ + + + V R+ G W PC C+
Sbjct: 736 EYTAILEGECCPRCVS--DPCLADNITYDIRKTCLDSYGVSRL-SGSVWTMAGSPCTTCK 792
Query: 384 CRGAQVTC 391
C+ +V C
Sbjct: 793 CKNGRVCC 800
Score = 50.4 bits (119), Expect = 3e-05
Identities = 31/98 (31%), Positives = 39/98 (39%), Gaps = 24/98 (24%)
Query: 45 SCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCPECVLRTPGSCHHEKKIHE- 103
SCQ CRC V C P C N C E I +CCP CV C + ++
Sbjct: 712 SCQQCRCLEGEVDCWPLTCPNLSC-----EYTAILEGECCPRCV---SDPCLADNITYDI 763
Query: 104 -------------HGTEW--ASSPCSVCSCNHGEVRCT 126
G+ W A SPC+ C C +G V C+
Sbjct: 764 RKTCLDSYGVSRLSGSVWTMAGSPCTTCKCKNGRVCCS 801
Score = 46.2 bits (108), Expect = 7e-04
Identities = 80/399 (20%), Positives = 135/399 (33%), Gaps = 106/399 (26%)
Query: 737 VLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHI------------- 783
++ DG+ + P+GY Q C + TC C SD +S I
Sbjct: 203 IIQDGKIIFM-PNGYITQ---CPNLNHTCPTC-----SDFLSLVQGIMDLQELLAKMTAK 253
Query: 784 ---------SLTNGNCRTSCREEQFLNLVGYCADCHHLCQHCAADLHNTGSICLRCQNAH 834
L N +C +C Q L+ D HC +G++ R +
Sbjct: 254 LNYAETRLSQLENCHCEKTC---QVSGLLYRDQDSWVDGDHCRNCTCKSGAVECRRMSCP 310
Query: 835 YLLLGDHCVPDCPSGYYAERGACKKCHSSCR-----TCQGRGPF--SCSSCDTNLVLSHT 887
L +C PD + A + CK C C +G+ SC C +++ T
Sbjct: 311 PL----NCSPDSLPVHIAGQ-CCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKIT 365
Query: 888 GTCST-TCFP-GHYLDDNHVCQPC--------------NTHCGSCDSQASCTSCRDPNKV 931
C C H L +N C+ C N+ C + +++A+C C+ +
Sbjct: 366 EMCPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATC-ECKS-GYI 423
Query: 932 LLFGECQY----ESCAPQYYLDFSTNTCKECD--WSCSACSGPLKTDCLQCMDGYVLQDG 985
+ G+ Y + CA + + + C + C G ++ D C + G
Sbjct: 424 SVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCTEHDECGSG 483
Query: 986 A--CVEQ--CLSSFYQDSGLCK---------CDSYCLQ-------CQGPHECTRCKGPFL 1025
C E C ++ S CK C ++C + C P++C
Sbjct: 484 QHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKCV------- 536
Query: 1026 LLEAQCVQECGKGYFADHAKHKCTACPQGCLQCSHRDRC 1064
C G+ H + C +G ++C + RC
Sbjct: 537 ---------CPSGFTGSHCEKDIDECSEGIIECHNHSRC 566
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 91.7 bits (226), Expect = 1e-17
Identities = 57/189 (30%), Positives = 80/189 (42%), Gaps = 33/189 (17%)
Query: 21 PH--HSEGACVYQDSLLADATIW--KPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVL 76
PH + G C++ + + IW + D C C C V+C+ VC C ++
Sbjct: 654 PHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC---DCENPTVDLF 710
Query: 77 QIAANQCCPECVLRTPGSCHHE--KKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLS 134
CCPEC R C H+ + ++ G W + C C C GEV C P PCP +
Sbjct: 711 ------CCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVE 763
Query: 135 CGHQELAFIPEGSCCPVCV-----------GLGKPCSYEGHVFQ-DGEDW--RLSRCAKC 180
C E + +PE CCP CV + K C E +V + G W + C C
Sbjct: 764 C---EFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 820
Query: 181 LCRNGVAQC 189
C+NG C
Sbjct: 821 QCKNGHICC 829
Score = 89.7 bits (221), Expect = 5e-17
Identities = 123/543 (22%), Positives = 183/543 (33%), Gaps = 122/543 (22%)
Query: 23 HSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQ 82
+ E C + + + W D C++C C + C+ +C NP C + L +
Sbjct: 292 YCERTCTMKGTTYREFESWI-DGCKNCTCLNGTIQCETLICPNPDCPLK--SALAYVDGK 348
Query: 83 CCPEC--VLRTPGSCHHEKKIHEHGTEWASS-PCSVCSCNHGEVRCTPQP-CPPLSCGHQ 138
CC EC + + G + E E T ++SS C + C ++ CP L C
Sbjct: 349 CCKECKSICQFQGRTYFE---GERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPES 405
Query: 139 ELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNG--VAQCFTAQCQP 196
+ SCC VC G CS + ++ L+ A C CR+G + A C+
Sbjct: 406 HQITLSH-SCCKVCKGYDF-CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCED 463
Query: 197 L--------FCNQDETVVRVPGKCCPQCSA-------RSCSAAGQVYEHGEQWSENACTT 241
+ +C ++ V PG C SC+ + + ENA
Sbjct: 464 IDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA--- 520
Query: 242 CICDRGEVRCHKQACLPLRCGKG-------QSRARRHGQC--CEECVSPAG----SCS-- 286
+C V H C P G G + R G C C P G SC
Sbjct: 521 -LC-FNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 578
Query: 287 ----YDGVVRYQDEM-------WKGSACEFCMCDHGQVTCQTGECAKVE--------CAR 327
DG V+ W C D+G + C ++ CA
Sbjct: 579 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 638
Query: 328 DEELIHLDG--KC-CPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW--EDGPCKVC 382
D +LDG C CP + G C+++ +VK G+ W E+ C VC
Sbjct: 639 DTICFNLDGGYDCRCPHGKNCTGDCIHD----------GKVKH--NGQIWVLENDRCSVC 686
Query: 383 ECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPT 442
C+ V C C C T+ L CCP+C DP
Sbjct: 687 SCQNGFVMCRRMVC-DCENPTVDL----FCCPEC-----------------------DPR 718
Query: 443 KLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPP------LLMRHGQCV 496
Q C+H G Y +G + QC ++C P ++ +C
Sbjct: 719 LSSQ---CLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECC 775
Query: 497 PTC 499
P C
Sbjct: 776 PRC 778
Score = 86.7 bits (213), Expect = 4e-16
Identities = 142/652 (21%), Positives = 200/652 (30%), Gaps = 150/652 (23%)
Query: 157 KPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQC 216
+ C+ +G +++ E W + C C C NG QC T C C + V GKCC +C
Sbjct: 295 RTCTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 353
Query: 217 SARSCSAAGQVYEHGEQ----WSENACTTCIC-DRGEVRCHKQACLPLRCGKGQSRARRH 271
+ C G+ Y GE+ S C C D+ C L C + H
Sbjct: 354 KS-ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSH 412
Query: 272 GQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEEL 331
CC+ C +FC H C +
Sbjct: 413 -SCCKVC----------------------KGYDFCSERH-------------NCMENSIC 436
Query: 332 IHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTC 391
+L+ + C R+G+ E + ++ EG + CR +
Sbjct: 437 RNLNDRAV--CSCRDGFRALREDNAY----CEDIDECAEGRHY---------CRENTMCV 481
Query: 392 YEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCV 451
P C T + + C + H +C+T + D LC + CV
Sbjct: 482 NTPGSFMCICKTGYIRIDDYSCTE------HDECITNQHNCDENALC---FNTVGGHNCV 532
Query: 452 HSCGLGFYQAGSLCLA-CQPQCSTCTSGLECSSCQPPLLMRHGQC---VPTCGDGFYQDR 507
C G+ G+ C A C+ C + + + C P C + C DGF Q
Sbjct: 533 --CKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQ-- 588
Query: 508 HSCAVCHESCAGCWG-PTEKHCLACRDPLHVLRDGG--------CE--SSCGKGFYN--R 554
C +S A C P HC CRD H D G CE CG G ++
Sbjct: 589 --C----DSRANCINLPGWYHC-ECRDGYH---DNGMFSPSGESCEDIDECGTGRHSCAN 638
Query: 555 QGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKV------- 607
C D D P C +HDGK G + RC V
Sbjct: 639 DTICFNLDGGYDCRCPHGKNC----TGDCIHDGKVKHN--GQIWVLENDRCSVCSCQNGF 692
Query: 608 --CHNSCASCSGPTPS--HCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACM 663
C C PT C C P + CL + GE Y+ C
Sbjct: 693 VMCRRMVCDCENPTVDLFCCPECDPRLS---SQCLHQNGETLYNSGDTWVQNCQQCRCLQ 749
Query: 664 GPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAG 723
G C E + +P EC +C + + C R
Sbjct: 750 GEVDCWPLPCPDVECEFSI-------LPENECCPRC----------VTDPCQADTIR--N 790
Query: 724 KSPHNCTD-------CGPSHVLLDGQC-LSQCPDGYFHQEGSCTECHPTCRQ 767
C D G S + +C L QC +G+ C P C Q
Sbjct: 791 DITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI-----CCSVDPQCLQ 837
Score = 80.9 bits (198), Expect = 2e-14
Identities = 111/482 (23%), Positives = 162/482 (33%), Gaps = 101/482 (20%)
Query: 43 PDSCQSCRCHGDIVICKP-------------AVCRNPQ----CAFEKGEVLQIAANQCCP 85
P+S Q H +CK ++CRN C+ G N C
Sbjct: 403 PESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCE 462
Query: 86 ECVLRTPGSCHHEKKIHEHGTEWASSPCS-VCSCNHGEVRCTPQPCPPL--------SCG 136
+ C + T ++P S +C C G +R C +C
Sbjct: 463 DI-----DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 517
Query: 137 HQELAFIPEGS----CCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTA 192
L F G C P G G C +DG CRNG A C A
Sbjct: 518 ENALCFNTVGGHNCVCKPGYTGNGTTCKA---FCKDG------------CRNGGA-CIAA 561
Query: 193 Q---CQPLFCNQD-ETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGE 248
C F ET + QC +R A + G W C D G
Sbjct: 562 NVCACPQGFTGPSCETDIDECSDGFVQCDSR----ANCINLPG--WYHCECRDGYHDNGM 615
Query: 249 VRCHKQACLPL-RCGKGQSRARRHGQCCE-----ECVSP-----AGSCSYDGVVRYQDEM 297
++C + CG G+ C +C P G C +DG V++ ++
Sbjct: 616 FSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQI 675
Query: 298 W--KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETG 355
W + C C C +G V C+ C D E +D CCPEC R + G
Sbjct: 676 WVLENDRCSVCSCQNGFVMCRRMVC-------DCENPTVDLFCCPECDPRLSSQCLHQNG 728
Query: 356 EFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPD 415
E + ++ G+ W C+ C C +V C+ CP ++ + +CCP
Sbjct: 729 ETLYNS---------GDTWVQN-CQQCRCLQGEVDCWPLPCPDVEC-EFSILPENECCPR 777
Query: 416 CTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQ---NGWCVH--SCGLGFYQAGSLCLACQP 470
C + C D + D C D +++ + W H C L + G +C + P
Sbjct: 778 CVTDPCQADTI----RNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 833
Query: 471 QC 472
QC
Sbjct: 834 QC 835
Score = 80.1 bits (196), Expect = 4e-14
Identities = 78/326 (23%), Positives = 113/326 (34%), Gaps = 65/326 (19%)
Query: 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVC----RNPQCAFEKGEV----LQIA 79
CV + + T K CR G + C P C + E +Q
Sbjct: 531 CVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCD 590
Query: 80 ANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCS----CNHGEVRCTPQPCPPLSC 135
+ C + PG H E + H S C C G SC
Sbjct: 591 SRANC----INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRH----------SC 636
Query: 136 GHQELAFIPEGSC---CPVCVGLGKPCSYEGHVFQDGEDWRLS--RCAKCLCRNGVAQCF 190
+ + F +G CP C ++G V +G+ W L RC+ C C+NG C
Sbjct: 637 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC- 695
Query: 191 TAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAA-----GQVYEHGEQWSENACTTCICD 245
+ + C+ + V + CCP+C R S +Y G+ W +N C C C
Sbjct: 696 ----RRMVCDCENPTVDL--FCCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCL 748
Query: 246 RGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYD--------------GVV 291
+GEV C C + C + +CC CV+ C D VV
Sbjct: 749 QGEVDCWPLPCPDVEC---EFSILPENECCPRCVTDP--CQADTIRNDITKTCLDEMNVV 803
Query: 292 RYQDEMW--KGSACEFCMCDHGQVTC 315
R+ W G+ C C C +G + C
Sbjct: 804 RFTGSSWIKHGTECTLCQCKNGHICC 829
Score = 54.7 bits (130), Expect = 2e-06
Identities = 91/374 (24%), Positives = 130/374 (34%), Gaps = 74/374 (19%)
Query: 748 PDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCA 807
P G+ Q PTC HG L + ++ T+ R EQ +N + C
Sbjct: 237 PQGFIAQCPDLNRTCPTCNDFHG-LVQKIMELQDILAKTSAKL---SRAEQRMNRLDQCY 292
Query: 808 DCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCV------PDCP---SGYYAERGACK 858
C C S C+N L C PDCP + Y + CK
Sbjct: 293 -CERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCK 351
Query: 859 KCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC-------------------STTCFPGHY 899
+C S C+ QGR F + N V S +G C + C H
Sbjct: 352 ECKSICQ-FQGRTYF---EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQ 407
Query: 900 LDDNH-VCQPC--------------NTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAP 944
+ +H C+ C N+ C + + +A C SCRD + L E
Sbjct: 408 ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVC-SCRDGFRALREDNAYCED--- 463
Query: 945 QYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYV-LQDGACVE--QCLSSFYQDSGL 1001
+D C + + P C+ C GY+ + D +C E +C+++ +
Sbjct: 464 ---IDECAEGRHYCRENTMCVNTPGSFMCI-CKTGYIRIDDYSCTEHDECITNQHN---- 515
Query: 1002 CKCDSYCLQCQGPHECTRCK----GPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQ 1057
C ++ C G H C CK G +A C C G A A + C ACPQG
Sbjct: 516 CDENALCFNTVGGHNCV-CKPGYTGNGTTCKAFCKDGCRNG-GACIAANVC-ACPQGFTG 572
Query: 1058 CSHRDRCHLCDHGF 1071
S C GF
Sbjct: 573 PSCETDIDECSDGF 586
Score = 49.3 bits (116), Expect = 8e-05
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 21/117 (17%)
Query: 28 CVYQ--DSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCP 85
C++Q ++L W +CQ CRC V C P C + +C F + N+CCP
Sbjct: 723 CLHQNGETLYNSGDTWV-QNCQQCRCLQGEVDCWPLPCPDVECEFSI-----LPENECCP 776
Query: 86 ECVLRT----------PGSCHHEKKIHEH-GTEWAS--SPCSVCSCNHGEVRCTPQP 129
CV +C E + G+ W + C++C C +G + C+ P
Sbjct: 777 RCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 833
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 91.7 bits (226), Expect = 1e-17
Identities = 57/189 (30%), Positives = 80/189 (42%), Gaps = 33/189 (17%)
Query: 21 PH--HSEGACVYQDSLLADATIW--KPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVL 76
PH + G C++ + + IW + D C C C V+C+ VC C ++
Sbjct: 630 PHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC---DCENPTVDLF 686
Query: 77 QIAANQCCPECVLRTPGSCHHE--KKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLS 134
CCPEC R C H+ + ++ G W + C C C GEV C P PCP +
Sbjct: 687 ------CCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVE 739
Query: 135 CGHQELAFIPEGSCCPVCV-----------GLGKPCSYEGHVFQ-DGEDW--RLSRCAKC 180
C E + +PE CCP CV + K C E +V + G W + C C
Sbjct: 740 C---EFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 796
Query: 181 LCRNGVAQC 189
C+NG C
Sbjct: 797 QCKNGHICC 805
Score = 89.7 bits (221), Expect = 5e-17
Identities = 123/543 (22%), Positives = 183/543 (33%), Gaps = 122/543 (22%)
Query: 23 HSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQ 82
+ E C + + + W D C++C C + C+ +C NP C + L +
Sbjct: 268 YCERTCTMKGTTYREFESWI-DGCKNCTCLNGTIQCETLICPNPDCPLK--SALAYVDGK 324
Query: 83 CCPEC--VLRTPGSCHHEKKIHEHGTEWASS-PCSVCSCNHGEVRCTPQP-CPPLSCGHQ 138
CC EC + + G + E E T ++SS C + C ++ CP L C
Sbjct: 325 CCKECKSICQFQGRTYFE---GERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPES 381
Query: 139 ELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNG--VAQCFTAQCQP 196
+ SCC VC G CS + ++ L+ A C CR+G + A C+
Sbjct: 382 HQITLSH-SCCKVCKGYDF-CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCED 439
Query: 197 L--------FCNQDETVVRVPGKCCPQCSA-------RSCSAAGQVYEHGEQWSENACTT 241
+ +C ++ V PG C SC+ + + ENA
Sbjct: 440 IDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA--- 496
Query: 242 CICDRGEVRCHKQACLPLRCGKG-------QSRARRHGQC--CEECVSPAG----SCS-- 286
+C V H C P G G + R G C C P G SC
Sbjct: 497 -LC-FNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 554
Query: 287 ----YDGVVRYQDEM-------WKGSACEFCMCDHGQVTCQTGECAKVE--------CAR 327
DG V+ W C D+G + C ++ CA
Sbjct: 555 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 614
Query: 328 DEELIHLDG--KC-CPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW--EDGPCKVC 382
D +LDG C CP + G C+++ +VK G+ W E+ C VC
Sbjct: 615 DTICFNLDGGYDCRCPHGKNCTGDCIHD----------GKVKH--NGQIWVLENDRCSVC 662
Query: 383 ECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPT 442
C+ V C C C T+ L CCP+C DP
Sbjct: 663 SCQNGFVMCRRMVC-DCENPTVDL----FCCPEC-----------------------DPR 694
Query: 443 KLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPP------LLMRHGQCV 496
Q C+H G Y +G + QC ++C P ++ +C
Sbjct: 695 LSSQ---CLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECC 751
Query: 497 PTC 499
P C
Sbjct: 752 PRC 754
Score = 86.7 bits (213), Expect = 4e-16
Identities = 142/652 (21%), Positives = 200/652 (30%), Gaps = 150/652 (23%)
Query: 157 KPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQC 216
+ C+ +G +++ E W + C C C NG QC T C C + V GKCC +C
Sbjct: 271 RTCTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 329
Query: 217 SARSCSAAGQVYEHGEQ----WSENACTTCIC-DRGEVRCHKQACLPLRCGKGQSRARRH 271
+ C G+ Y GE+ S C C D+ C L C + H
Sbjct: 330 KS-ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSH 388
Query: 272 GQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEEL 331
CC+ C +FC H C +
Sbjct: 389 -SCCKVC----------------------KGYDFCSERH-------------NCMENSIC 412
Query: 332 IHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTC 391
+L+ + C R+G+ E + ++ EG + CR +
Sbjct: 413 RNLNDRAV--CSCRDGFRALREDNAY----CEDIDECAEGRHY---------CRENTMCV 457
Query: 392 YEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCV 451
P C T + + C + H +C+T + D LC + CV
Sbjct: 458 NTPGSFMCICKTGYIRIDDYSCTE------HDECITNQHNCDENALC---FNTVGGHNCV 508
Query: 452 HSCGLGFYQAGSLCLA-CQPQCSTCTSGLECSSCQPPLLMRHGQC---VPTCGDGFYQDR 507
C G+ G+ C A C+ C + + + C P C + C DGF Q
Sbjct: 509 --CKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQ-- 564
Query: 508 HSCAVCHESCAGCWG-PTEKHCLACRDPLHVLRDGG--------CE--SSCGKGFYN--R 554
C +S A C P HC CRD H D G CE CG G ++
Sbjct: 565 --C----DSRANCINLPGWYHC-ECRDGYH---DNGMFSPSGESCEDIDECGTGRHSCAN 614
Query: 555 QGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKV------- 607
C D D P C +HDGK G + RC V
Sbjct: 615 DTICFNLDGGYDCRCPHGKNC----TGDCIHDGKVKHN--GQIWVLENDRCSVCSCQNGF 668
Query: 608 --CHNSCASCSGPTPS--HCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACM 663
C C PT C C P + CL + GE Y+ C
Sbjct: 669 VMCRRMVCDCENPTVDLFCCPECDPRLS---SQCLHQNGETLYNSGDTWVQNCQQCRCLQ 725
Query: 664 GPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAG 723
G C E + +P EC +C + + C R
Sbjct: 726 GEVDCWPLPCPDVECEFSI-------LPENECCPRC----------VTDPCQADTIR--N 766
Query: 724 KSPHNCTD-------CGPSHVLLDGQC-LSQCPDGYFHQEGSCTECHPTCRQ 767
C D G S + +C L QC +G+ C P C Q
Sbjct: 767 DITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI-----CCSVDPQCLQ 813
Score = 80.9 bits (198), Expect = 2e-14
Identities = 111/482 (23%), Positives = 162/482 (33%), Gaps = 101/482 (20%)
Query: 43 PDSCQSCRCHGDIVICKP-------------AVCRNPQ----CAFEKGEVLQIAANQCCP 85
P+S Q H +CK ++CRN C+ G N C
Sbjct: 379 PESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCE 438
Query: 86 ECVLRTPGSCHHEKKIHEHGTEWASSPCS-VCSCNHGEVRCTPQPCPPL--------SCG 136
+ C + T ++P S +C C G +R C +C
Sbjct: 439 DI-----DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 493
Query: 137 HQELAFIPEGS----CCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTA 192
L F G C P G G C +DG CRNG A C A
Sbjct: 494 ENALCFNTVGGHNCVCKPGYTGNGTTCKA---FCKDG------------CRNGGA-CIAA 537
Query: 193 Q---CQPLFCNQD-ETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGE 248
C F ET + QC +R A + G W C D G
Sbjct: 538 NVCACPQGFTGPSCETDIDECSDGFVQCDSR----ANCINLPG--WYHCECRDGYHDNGM 591
Query: 249 VRCHKQACLPL-RCGKGQSRARRHGQCCE-----ECVSP-----AGSCSYDGVVRYQDEM 297
++C + CG G+ C +C P G C +DG V++ ++
Sbjct: 592 FSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQI 651
Query: 298 W--KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETG 355
W + C C C +G V C+ C D E +D CCPEC R + G
Sbjct: 652 WVLENDRCSVCSCQNGFVMCRRMVC-------DCENPTVDLFCCPECDPRLSSQCLHQNG 704
Query: 356 EFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPD 415
E + ++ G+ W C+ C C +V C+ CP ++ + +CCP
Sbjct: 705 ETLYNS---------GDTWVQN-CQQCRCLQGEVDCWPLPCPDVEC-EFSILPENECCPR 753
Query: 416 CTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQ---NGWCVH--SCGLGFYQAGSLCLACQP 470
C + C D + D C D +++ + W H C L + G +C + P
Sbjct: 754 CVTDPCQADTI----RNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 809
Query: 471 QC 472
QC
Sbjct: 810 QC 811
Score = 80.1 bits (196), Expect = 4e-14
Identities = 78/326 (23%), Positives = 113/326 (34%), Gaps = 65/326 (19%)
Query: 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVC----RNPQCAFEKGEV----LQIA 79
CV + + T K CR G + C P C + E +Q
Sbjct: 507 CVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCD 566
Query: 80 ANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCS----CNHGEVRCTPQPCPPLSC 135
+ C + PG H E + H S C C G SC
Sbjct: 567 SRANC----INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRH----------SC 612
Query: 136 GHQELAFIPEGSC---CPVCVGLGKPCSYEGHVFQDGEDWRLS--RCAKCLCRNGVAQCF 190
+ + F +G CP C ++G V +G+ W L RC+ C C+NG C
Sbjct: 613 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC- 671
Query: 191 TAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAA-----GQVYEHGEQWSENACTTCICD 245
+ + C+ + V + CCP+C R S +Y G+ W +N C C C
Sbjct: 672 ----RRMVCDCENPTVDL--FCCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCL 724
Query: 246 RGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYD--------------GVV 291
+GEV C C + C + +CC CV+ C D VV
Sbjct: 725 QGEVDCWPLPCPDVEC---EFSILPENECCPRCVTDP--CQADTIRNDITKTCLDEMNVV 779
Query: 292 RYQDEMW--KGSACEFCMCDHGQVTC 315
R+ W G+ C C C +G + C
Sbjct: 780 RFTGSSWIKHGTECTLCQCKNGHICC 805
Score = 54.7 bits (130), Expect = 2e-06
Identities = 91/374 (24%), Positives = 130/374 (34%), Gaps = 74/374 (19%)
Query: 748 PDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCA 807
P G+ Q PTC HG L + ++ T+ R EQ +N + C
Sbjct: 213 PQGFIAQCPDLNRTCPTCNDFHG-LVQKIMELQDILAKTSAKL---SRAEQRMNRLDQCY 268
Query: 808 DCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCV------PDCP---SGYYAERGACK 858
C C S C+N L C PDCP + Y + CK
Sbjct: 269 -CERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCK 327
Query: 859 KCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC-------------------STTCFPGHY 899
+C S C+ QGR F + N V S +G C + C H
Sbjct: 328 ECKSICQ-FQGRTYF---EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQ 383
Query: 900 LDDNH-VCQPC--------------NTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAP 944
+ +H C+ C N+ C + + +A C SCRD + L E
Sbjct: 384 ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVC-SCRDGFRALREDNAYCED--- 439
Query: 945 QYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYV-LQDGACVE--QCLSSFYQDSGL 1001
+D C + + P C+ C GY+ + D +C E +C+++ +
Sbjct: 440 ---IDECAEGRHYCRENTMCVNTPGSFMCI-CKTGYIRIDDYSCTEHDECITNQHN---- 491
Query: 1002 CKCDSYCLQCQGPHECTRCK----GPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQ 1057
C ++ C G H C CK G +A C C G A A + C ACPQG
Sbjct: 492 CDENALCFNTVGGHNCV-CKPGYTGNGTTCKAFCKDGCRNG-GACIAANVC-ACPQGFTG 548
Query: 1058 CSHRDRCHLCDHGF 1071
S C GF
Sbjct: 549 PSCETDIDECSDGF 562
Score = 49.3 bits (116), Expect = 8e-05
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 21/117 (17%)
Query: 28 CVYQ--DSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCP 85
C++Q ++L W +CQ CRC V C P C + +C F + N+CCP
Sbjct: 699 CLHQNGETLYNSGDTWV-QNCQQCRCLQGEVDCWPLPCPDVECEFSI-----LPENECCP 752
Query: 86 ECVLRT----------PGSCHHEKKIHEH-GTEWAS--SPCSVCSCNHGEVRCTPQP 129
CV +C E + G+ W + C++C C +G + C+ P
Sbjct: 753 RCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 809
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 91.7 bits (226), Expect = 1e-17
Identities = 57/189 (30%), Positives = 80/189 (42%), Gaps = 33/189 (17%)
Query: 21 PH--HSEGACVYQDSLLADATIW--KPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVL 76
PH + G C++ + + IW + D C C C V+C+ VC C ++
Sbjct: 631 PHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC---DCENPTVDLF 687
Query: 77 QIAANQCCPECVLRTPGSCHHE--KKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLS 134
CCPEC R C H+ + ++ G W + C C C GEV C P PCP +
Sbjct: 688 ------CCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCLQGEVDCWPLPCPDVE 740
Query: 135 CGHQELAFIPEGSCCPVCV-----------GLGKPCSYEGHVFQ-DGEDW--RLSRCAKC 180
C E + +PE CCP CV + K C E +V + G W + C C
Sbjct: 741 C---EFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 797
Query: 181 LCRNGVAQC 189
C+NG C
Sbjct: 798 QCKNGHICC 806
Score = 89.7 bits (221), Expect = 5e-17
Identities = 123/543 (22%), Positives = 183/543 (33%), Gaps = 122/543 (22%)
Query: 23 HSEGACVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQ 82
+ E C + + + W D C++C C + C+ +C NP C + L +
Sbjct: 269 YCERTCTMKGTTYREFESWI-DGCKNCTCLNGTIQCETLICPNPDCPLK--SALAYVDGK 325
Query: 83 CCPEC--VLRTPGSCHHEKKIHEHGTEWASS-PCSVCSCNHGEVRCTPQP-CPPLSCGHQ 138
CC EC + + G + E E T ++SS C + C ++ CP L C
Sbjct: 326 CCKECKSICQFQGRTYFE---GERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPES 382
Query: 139 ELAFIPEGSCCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNG--VAQCFTAQCQP 196
+ SCC VC G CS + ++ L+ A C CR+G + A C+
Sbjct: 383 HQITLSH-SCCKVCKGYDF-CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCED 440
Query: 197 L--------FCNQDETVVRVPGKCCPQCSA-------RSCSAAGQVYEHGEQWSENACTT 241
+ +C ++ V PG C SC+ + + ENA
Sbjct: 441 IDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA--- 497
Query: 242 CICDRGEVRCHKQACLPLRCGKG-------QSRARRHGQC--CEECVSPAG----SCS-- 286
+C V H C P G G + R G C C P G SC
Sbjct: 498 -LC-FNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETD 555
Query: 287 ----YDGVVRYQDEM-------WKGSACEFCMCDHGQVTCQTGECAKVE--------CAR 327
DG V+ W C D+G + C ++ CA
Sbjct: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
Query: 328 DEELIHLDG--KC-CPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKW--EDGPCKVC 382
D +LDG C CP + G C+++ +VK G+ W E+ C VC
Sbjct: 616 DTICFNLDGGYDCRCPHGKNCTGDCIHD----------GKVKH--NGQIWVLENDRCSVC 663
Query: 383 ECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPT 442
C+ V C C C T+ L CCP+C DP
Sbjct: 664 SCQNGFVMCRRMVC-DCENPTVDL----FCCPEC-----------------------DPR 695
Query: 443 KLLQNGWCVHSCGLGFYQAGSLCLACQPQCSTCTSGLECSSCQPP------LLMRHGQCV 496
Q C+H G Y +G + QC ++C P ++ +C
Sbjct: 696 LSSQ---CLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECC 752
Query: 497 PTC 499
P C
Sbjct: 753 PRC 755
Score = 86.7 bits (213), Expect = 4e-16
Identities = 142/652 (21%), Positives = 200/652 (30%), Gaps = 150/652 (23%)
Query: 157 KPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQC 216
+ C+ +G +++ E W + C C C NG QC T C C + V GKCC +C
Sbjct: 272 RTCTMKGTTYREFESW-IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 330
Query: 217 SARSCSAAGQVYEHGEQ----WSENACTTCIC-DRGEVRCHKQACLPLRCGKGQSRARRH 271
+ C G+ Y GE+ S C C D+ C L C + H
Sbjct: 331 KS-ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
Query: 272 GQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECARDEEL 331
CC+ C +FC H C +
Sbjct: 390 -SCCKVC----------------------KGYDFCSERH-------------NCMENSIC 413
Query: 332 IHLDGKCCPECISRNGYCVYEETGEFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTC 391
+L+ + C R+G+ E + ++ EG + CR +
Sbjct: 414 RNLNDRAV--CSCRDGFRALREDNAY----CEDIDECAEGRHY---------CRENTMCV 458
Query: 392 YEPSCPPCPVGTLALEVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCV 451
P C T + + C + H +C+T + D LC + CV
Sbjct: 459 NTPGSFMCICKTGYIRIDDYSCTE------HDECITNQHNCDENALC---FNTVGGHNCV 509
Query: 452 HSCGLGFYQAGSLCLA-CQPQCSTCTSGLECSSCQPPLLMRHGQC---VPTCGDGFYQDR 507
C G+ G+ C A C+ C + + + C P C + C DGF Q
Sbjct: 510 --CKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQ-- 565
Query: 508 HSCAVCHESCAGCWG-PTEKHCLACRDPLHVLRDGG--------CE--SSCGKGFYN--R 554
C +S A C P HC CRD H D G CE CG G ++
Sbjct: 566 --C----DSRANCINLPGWYHC-ECRDGYH---DNGMFSPSGESCEDIDECGTGRHSCAN 615
Query: 555 QGTCSACDQSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKV------- 607
C D D P C +HDGK G + RC V
Sbjct: 616 DTICFNLDGGYDCRCPHGKNC----TGDCIHDGKVKHN--GQIWVLENDRCSVCSCQNGF 669
Query: 608 --CHNSCASCSGPTPS--HCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACM 663
C C PT C C P + CL + GE Y+ C
Sbjct: 670 VMCRRMVCDCENPTVDLFCCPECDPRLS---SQCLHQNGETLYNSGDTWVQNCQQCRCLQ 726
Query: 664 GPAPSHCTGCKKPEEGLQVEQLSDVGIPSGECLAQCRAHFYLESTGICEACHQSCFRCAG 723
G C E + +P EC +C + + C R
Sbjct: 727 GEVDCWPLPCPDVECEFSI-------LPENECCPRC----------VTDPCQADTIR--N 767
Query: 724 KSPHNCTD-------CGPSHVLLDGQC-LSQCPDGYFHQEGSCTECHPTCRQ 767
C D G S + +C L QC +G+ C P C Q
Sbjct: 768 DITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI-----CCSVDPQCLQ 814
Score = 80.9 bits (198), Expect = 2e-14
Identities = 111/482 (23%), Positives = 162/482 (33%), Gaps = 101/482 (20%)
Query: 43 PDSCQSCRCHGDIVICKP-------------AVCRNPQ----CAFEKGEVLQIAANQCCP 85
P+S Q H +CK ++CRN C+ G N C
Sbjct: 380 PESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCE 439
Query: 86 ECVLRTPGSCHHEKKIHEHGTEWASSPCS-VCSCNHGEVRCTPQPCPPL--------SCG 136
+ C + T ++P S +C C G +R C +C
Sbjct: 440 DI-----DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 494
Query: 137 HQELAFIPEGS----CCPVCVGLGKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTA 192
L F G C P G G C +DG CRNG A C A
Sbjct: 495 ENALCFNTVGGHNCVCKPGYTGNGTTCKA---FCKDG------------CRNGGA-CIAA 538
Query: 193 Q---CQPLFCNQD-ETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSENACTTCICDRGE 248
C F ET + QC +R A + G W C D G
Sbjct: 539 NVCACPQGFTGPSCETDIDECSDGFVQCDSR----ANCINLPG--WYHCECRDGYHDNGM 592
Query: 249 VRCHKQACLPL-RCGKGQSRARRHGQCCE-----ECVSP-----AGSCSYDGVVRYQDEM 297
++C + CG G+ C +C P G C +DG V++ ++
Sbjct: 593 FSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQI 652
Query: 298 W--KGSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETG 355
W + C C C +G V C+ C D E +D CCPEC R + G
Sbjct: 653 WVLENDRCSVCSCQNGFVMCRRMVC-------DCENPTVDLFCCPECDPRLSSQCLHQNG 705
Query: 356 EFMSSNASEVKRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPPCPVGTLALEVKGQCCPD 415
E + ++ G+ W C+ C C +V C+ CP ++ + +CCP
Sbjct: 706 ETLYNS---------GDTWVQN-CQQCRCLQGEVDCWPLPCPDVEC-EFSILPENECCPR 754
Query: 416 CTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQ---NGWCVH--SCGLGFYQAGSLCLACQP 470
C + C D + D C D +++ + W H C L + G +C + P
Sbjct: 755 CVTDPCQADTI----RNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 810
Query: 471 QC 472
QC
Sbjct: 811 QC 812
Score = 80.1 bits (196), Expect = 4e-14
Identities = 78/326 (23%), Positives = 113/326 (34%), Gaps = 65/326 (19%)
Query: 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVC----RNPQCAFEKGEV----LQIA 79
CV + + T K CR G + C P C + E +Q
Sbjct: 508 CVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCD 567
Query: 80 ANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCSVCS----CNHGEVRCTPQPCPPLSC 135
+ C + PG H E + H S C C G SC
Sbjct: 568 SRANC----INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRH----------SC 613
Query: 136 GHQELAFIPEGSC---CPVCVGLGKPCSYEGHVFQDGEDWRLS--RCAKCLCRNGVAQCF 190
+ + F +G CP C ++G V +G+ W L RC+ C C+NG C
Sbjct: 614 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC- 672
Query: 191 TAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAA-----GQVYEHGEQWSENACTTCICD 245
+ + C+ + V + CCP+C R S +Y G+ W +N C C C
Sbjct: 673 ----RRMVCDCENPTVDL--FCCPECDPRLSSQCLHQNGETLYNSGDTWVQN-CQQCRCL 725
Query: 246 RGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYD--------------GVV 291
+GEV C C + C + +CC CV+ C D VV
Sbjct: 726 QGEVDCWPLPCPDVEC---EFSILPENECCPRCVTDP--CQADTIRNDITKTCLDEMNVV 780
Query: 292 RYQDEMW--KGSACEFCMCDHGQVTC 315
R+ W G+ C C C +G + C
Sbjct: 781 RFTGSSWIKHGTECTLCQCKNGHICC 806
Score = 54.7 bits (130), Expect = 2e-06
Identities = 91/374 (24%), Positives = 130/374 (34%), Gaps = 74/374 (19%)
Query: 748 PDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLNLVGYCA 807
P G+ Q PTC HG L + ++ T+ R EQ +N + C
Sbjct: 214 PQGFIAQCPDLNRTCPTCNDFHG-LVQKIMELQDILAKTSAKL---SRAEQRMNRLDQCY 269
Query: 808 DCHHLCQHCAADLHNTGSICLRCQNAHYLLLGDHCV------PDCP---SGYYAERGACK 858
C C S C+N L C PDCP + Y + CK
Sbjct: 270 -CERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCK 328
Query: 859 KCHSSCRTCQGRGPFSCSSCDTNLVLSHTGTC-------------------STTCFPGHY 899
+C S C+ QGR F + N V S +G C + C H
Sbjct: 329 ECKSICQ-FQGRTYF---EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQ 384
Query: 900 LDDNH-VCQPC--------------NTHCGSCDSQASCTSCRDPNKVLLFGECQYESCAP 944
+ +H C+ C N+ C + + +A C SCRD + L E
Sbjct: 385 ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVC-SCRDGFRALREDNAYCED--- 440
Query: 945 QYYLDFSTNTCKECDWSCSACSGPLKTDCLQCMDGYV-LQDGACVE--QCLSSFYQDSGL 1001
+D C + + P C+ C GY+ + D +C E +C+++ +
Sbjct: 441 ---IDECAEGRHYCRENTMCVNTPGSFMCI-CKTGYIRIDDYSCTEHDECITNQHN---- 492
Query: 1002 CKCDSYCLQCQGPHECTRCK----GPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCLQ 1057
C ++ C G H C CK G +A C C G A A + C ACPQG
Sbjct: 493 CDENALCFNTVGGHNCV-CKPGYTGNGTTCKAFCKDGCRNG-GACIAANVC-ACPQGFTG 549
Query: 1058 CSHRDRCHLCDHGF 1071
S C GF
Sbjct: 550 PSCETDIDECSDGF 563
Score = 49.3 bits (116), Expect = 8e-05
Identities = 31/117 (26%), Positives = 49/117 (41%), Gaps = 21/117 (17%)
Query: 28 CVYQ--DSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEVLQIAANQCCP 85
C++Q ++L W +CQ CRC V C P C + +C F + N+CCP
Sbjct: 700 CLHQNGETLYNSGDTWV-QNCQQCRCLQGEVDCWPLPCPDVECEFSI-----LPENECCP 753
Query: 86 ECVLRT----------PGSCHHEKKIHEH-GTEWAS--SPCSVCSCNHGEVRCTPQP 129
CV +C E + G+ W + C++C C +G + C+ P
Sbjct: 754 RCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDP 810
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 172,543,151
Number of Sequences: 37866
Number of extensions: 8869407
Number of successful extensions: 31968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 566
Number of HSP's that attempted gapping in prelim test: 23328
Number of HSP's gapped (non-prelim): 4829
length of query: 4011
length of database: 18,247,518
effective HSP length: 122
effective length of query: 3889
effective length of database: 13,627,866
effective search space: 52998770874
effective search space used: 52998770874
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.