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Search of human proteins with 4557741
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557741 platelet-activating factor acetylhydrolase, isoform
Ib, alpha subunit [Homo sapiens]
(410 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 850 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 187 2e-47
gi|16554627 WD repeat domain 5 [Homo sapiens] 187 2e-47
gi|23199987 WD repeat domain 5B [Homo sapiens] 179 5e-45
gi|32189425 WD repeat domain 69 [Homo sapiens] 164 1e-40
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 163 3e-40
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 163 3e-40
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 163 3e-40
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 157 2e-38
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 157 2e-38
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 146 3e-35
gi|113865883 WD repeat domain 38 [Homo sapiens] 145 8e-35
gi|26665869 WD repeat domain 51B [Homo sapiens] 142 4e-34
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 134 1e-31
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 131 1e-30
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 130 2e-30
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 129 5e-30
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 129 5e-30
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 129 6e-30
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 126 4e-29
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 124 1e-28
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 124 1e-28
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 124 1e-28
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 120 3e-27
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 119 5e-27
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 118 1e-26
gi|19913367 transducin beta-like 1Y [Homo sapiens] 117 1e-26
gi|19913365 transducin beta-like 1Y [Homo sapiens] 117 1e-26
gi|15150805 transducin beta-like 1Y [Homo sapiens] 117 1e-26
gi|19913369 transducin beta-like 3 [Homo sapiens] 117 1e-26
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 850 bits (2195), Expect = 0.0
Identities = 410/410 (100%), Positives = 410/410 (100%)
Query: 1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR 60
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR
Sbjct: 1 MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDVNEELDKKYAGLLEKKWTSVIR 60
Query: 61 LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF 120
LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF
Sbjct: 61 LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF 120
Query: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240
GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMV 240
Query: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE
Sbjct: 241 RPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
Query: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Query: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
Sbjct: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 187 bits (474), Expect = 2e-47
Identities = 100/313 (31%), Positives = 165/313 (52%), Gaps = 24/313 (7%)
Query: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
K+ L+GH V+ V F P + S+S D IK+W G FE+T+ GH + D+++
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
LL S S D T+K+WD +C++T+ GH + V P + IVS S D+++++W+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
V+TG C+KT H + V V N+DG+LI S S D R+W A+ +C L + ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--- 214
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
P S+ S G ++L+ + D T+K+WD S G CL T GH N
Sbjct: 215 -----PPVSFVKFS-----------PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
Query: 341 VRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397
+ + +GGK+I+S ++D + +W+ + K ++ L H V S H T + +
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 398 GSV--DQTVKVWE 408
++ D+T+K+W+
Sbjct: 319 AALENDKTIKLWK 331
Score = 84.7 bits (208), Expect = 1e-16
Identities = 36/103 (34%), Positives = 62/103 (60%)
Query: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
G +L S S DK IK+W G T+ GH + V + S ++S +DDKTL++WD
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Query: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
+ +C+KTL H ++V +F+ + +V+GS D++V++W+ +
Sbjct: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 187 bits (474), Expect = 2e-47
Identities = 100/313 (31%), Positives = 165/313 (52%), Gaps = 24/313 (7%)
Query: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
K+ L+GH V+ V F P + S+S D IK+W G FE+T+ GH + D+++
Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
LL S S D T+K+WD +C++T+ GH + V P + IVS S D+++++W+
Sbjct: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
V+TG C+KT H + V V N+DG+LI S S D R+W A+ +C L + ++
Sbjct: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--- 214
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
P S+ S G ++L+ + D T+K+WD S G CL T GH N
Sbjct: 215 -----PPVSFVKFS-----------PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
Query: 341 VRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397
+ + +GGK+I+S ++D + +W+ + K ++ L H V S H T + +
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 398 GSV--DQTVKVWE 408
++ D+T+K+W+
Sbjct: 319 AALENDKTIKLWK 331
Score = 84.7 bits (208), Expect = 1e-16
Identities = 36/103 (34%), Positives = 62/103 (60%)
Query: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
G +L S S DK IK+W G T+ GH + V + S ++S +DDKTL++WD
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Query: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
+ +C+KTL H ++V +F+ + +V+GS D++V++W+ +
Sbjct: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 179 bits (453), Expect = 5e-45
Identities = 105/339 (30%), Positives = 169/339 (49%), Gaps = 25/339 (7%)
Query: 74 EAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIK 133
+AK + Q ++ E P K L GH V+ V F P + S+S D I
Sbjct: 8 DAKAQLALSSSANQSKEVPE-NPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLII 66
Query: 134 VWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193
+W G +E+TL GH + D+++ L S S D T+KLWD + +C++T+ GH +
Sbjct: 67 IWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSN 126
Query: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
V P + I+S S D+T+K+WEV+TG C+KT + H + V V N G+LI S S
Sbjct: 127 YVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGS 186
Query: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
D R+W A+ +C L + ++ P S+ S G ++L+
Sbjct: 187 YDGLCRIWDAASGQCLKTLVDDDN--------PPVSFVKFS-----------PNGKYILT 227
Query: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH---SGGKFILSCADDKTLRVWDYKNK 370
+ D T+K+WD S G CL T GH N + + +GGK+I+S ++D + +W+ + K
Sbjct: 228 ATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK 287
Query: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSV--DQTVKVW 407
++ L H V S H T + + ++ D+T+K+W
Sbjct: 288 EIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 135 bits (340), Expect = 7e-32
Identities = 78/253 (30%), Positives = 131/253 (51%), Gaps = 21/253 (8%)
Query: 157 SFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
S D +L S SA+ + ++ + + T+ GH VSSV PNG+ + S+S D+ I
Sbjct: 6 SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65
Query: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276
+W G KT GH + V + D + + S S+D+T+++W V + +C L+ H
Sbjct: 66 IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHS 125
Query: 277 HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
+ V C ++ P P ++SGS D+T+K+W+V TG CL TL
Sbjct: 126 NYVFCCNFNP--------------------PSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
Query: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEH-FVTSLDFHKTAPYV 395
H + V V F+ G I+S + D R+WD + +C+KTL ++ V+ + F Y+
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYI 225
Query: 396 VTGSVDQTVKVWE 408
+T ++D T+K+W+
Sbjct: 226 LTATLDNTLKLWD 238
Score = 102 bits (254), Expect = 6e-22
Identities = 59/207 (28%), Positives = 102/207 (49%), Gaps = 48/207 (23%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L GH + V F+P ++++S S D T+K+W+ +TG +TL H+D V + F+ SG
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHN-VSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
L+ S S D ++WD +C++T+ D+ VS V PNG +I++A+ D T+K+W+
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYS 240
Query: 223 TGYCVKTFTGHR-----------------------------------EWVRMVRPNQDGT 247
G C+KT+TGH+ E V+ ++ + D
Sbjct: 241 RGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 300
Query: 248 LIASC------------SNDQTVRVWV 262
+ A+C ND+T+++W+
Sbjct: 301 ISAACHPTENLIASAALENDKTIKLWM 327
Score = 86.3 bits (212), Expect = 5e-17
Identities = 51/157 (32%), Positives = 86/157 (54%), Gaps = 11/157 (7%)
Query: 263 VATKE---CKAEL------REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
+ATKE KA+L + + V E ++A + + +EA S K G +L S
Sbjct: 1 MATKESRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSV--KFSPNGEWLAS 58
Query: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
S D+ I +W G TL GH+ + V + S ++S +DDKTL++WD ++ +C+
Sbjct: 59 SSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCL 118
Query: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
KTL H ++V +F+ + +++GS D+TVK+WE +
Sbjct: 119 KTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 164 bits (415), Expect = 1e-40
Identities = 92/311 (29%), Positives = 149/311 (47%), Gaps = 25/311 (8%)
Query: 100 EKYALSGHRSPVTRVIFH-PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF 158
E L GHR+ V + F+ P + + S D T K+W ETG T +GHT + +SF
Sbjct: 126 ELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSF 185
Query: 159 DHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKM 218
+ L+A+ S D T KLWD Q E + T+ GH + S++ +GD I++ S D T+ +
Sbjct: 186 NPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245
Query: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
W+ TG V GH + N D +LI + S D+T ++W +C A L H+
Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
Query: 279 V--ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
+ C + G + + S D T +++ +T C+ L G
Sbjct: 306 ILDSCFDYT----------------------GKLIATASADGTARIFSAATRKCIAKLEG 343
Query: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
H+ + + F+ G +L+ + DKT R+WD + +C++ L H + S F+ V+
Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVI 403
Query: 397 TGSVDQTVKVW 407
TGS D T ++W
Sbjct: 404 TGSKDNTCRIW 414
Score = 158 bits (400), Expect = 7e-39
Identities = 92/308 (29%), Positives = 148/308 (48%), Gaps = 21/308 (6%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS-G 162
L H P+T V + S ++ S D T K+WD +G+ TL+GH + V I+F++ G
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
+A+ S D T KLW + +C T GH + ++ P + + S D T K+W++Q
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
G V T GH + + N G I + S D TV VW T L H +
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSA 267
Query: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
S+ + S +L+GS DKT K+WD + G C+ TL GHD+ +
Sbjct: 268 SFNWDCS--------------------LILTGSMDKTCKLWDATNGKCVATLTGHDDEIL 307
Query: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
F GK I + + D T R++ ++C+ L HE ++ + F+ +++TGS D+
Sbjct: 308 DSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDK 367
Query: 403 TVKVWECR 410
T ++W+ +
Sbjct: 368 TARIWDAQ 375
Score = 110 bits (275), Expect = 2e-24
Identities = 65/228 (28%), Positives = 113/228 (49%), Gaps = 21/228 (9%)
Query: 182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241
F + + H +++VA+ +G ++ S D+T K+W+ +G + T GHR V +
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIA 141
Query: 242 PNQD-GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSE 300
N G IA+ S D+T ++W V T +C R H + C+S+ P+S+
Sbjct: 142 FNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST----------- 190
Query: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
+ +GS D T K+WD+ G + TL GH + + F++ G I++ + D
Sbjct: 191 ---------LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH 241
Query: 361 TLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
T+ VWD R + L H ++S F+ ++TGS+D+T K+W+
Sbjct: 242 TVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
Score = 83.6 bits (205), Expect = 3e-16
Identities = 53/186 (28%), Positives = 84/186 (45%), Gaps = 19/186 (10%)
Query: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282
T Y K H + V N+ G+ + S D+T ++W A+ E L H +VV I
Sbjct: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140
Query: 283 SWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
++ + G + +GS DKT K+W V TG C T GH +
Sbjct: 141 AF-------------------NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIV 181
Query: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQ 402
+ F+ + + + D T ++WD +N + TL H + SL F+ + ++TGS D
Sbjct: 182 CLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH 241
Query: 403 TVKVWE 408
TV VW+
Sbjct: 242 TVVVWD 247
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 163 bits (412), Expect = 3e-40
Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 35/291 (12%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
+VS S+D T+KVW TG RTL GHT V S ++ S S D T+K+W+ +
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWNAETG 333
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
ECI T++GH V + + + +VS SRD T+++W+++TG C+ GH VR V+
Sbjct: 334 ECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ- 390
Query: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
DG + S + D V+VW T+ C L+ H + V + +
Sbjct: 391 -YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF------------------ 431
Query: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
G ++SGS D +I++WDV TG C+ TL GH + G+ ++S D T+
Sbjct: 432 ----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTV 485
Query: 363 RVWDYKNKRCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
++WD K +C++TL N H+ VT L F+K +V+T S D TVK+W+ +
Sbjct: 486 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLK 534
Score = 134 bits (336), Expect = 2e-31
Identities = 83/260 (31%), Positives = 136/260 (52%), Gaps = 35/260 (13%)
Query: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
++++S S D T+KVW+ ETG+ TL GHT +V+ + K + S S D T+++WD +
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 371
Query: 181 GFECIRTMHGHDHNVSSV-AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239
+C+ + GH V++V + +G +VS + D +K+W+ +T C+ T GH R+
Sbjct: 372 TGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RV 426
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
DG + S S D ++RVW V T C L H+ S +G
Sbjct: 427 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-----------------SLTSGM 469
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSC 356
E K + L+SG+ D T+K+WD+ TG CL TL G H + V + F+ F+++
Sbjct: 470 ELKDN-----ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITS 522
Query: 357 ADDKTLRVWDYKNKRCMKTL 376
+DD T+++WD K ++ L
Sbjct: 523 SDDGTVKLWDLKTGEFIRNL 542
Score = 125 bits (315), Expect = 5e-29
Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 33/237 (13%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L GH S V + H +VS S DAT++VWD ETG L GH +V+ + +D
Sbjct: 337 HTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-- 392
Query: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
G+ + S + D +K+WD + C+ T+ GH + V S+ +G H+VS S D +I++W+V
Sbjct: 393 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV 450
Query: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR---EHEHV 278
+TG C+ T TGH+ + + ++ S + D TV++W + T +C L+ +H+
Sbjct: 451 ETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508
Query: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335
V C+ + F+++ S D T+K+WD+ TG + LV
Sbjct: 509 VTCLQFNKN----------------------FVITSSDDGTVKLWDLKTGEFIRNLV 543
Score = 123 bits (308), Expect = 3e-28
Identities = 76/225 (33%), Positives = 117/225 (52%), Gaps = 33/225 (14%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHR--EWVRMVRPN 243
+ + GHD +V + + G+ IVS S D T+K+W TG C++T GH W +R N
Sbjct: 256 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 314
Query: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303
+I S S D+T++VW T EC L H V C+ +
Sbjct: 315 ----IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--------------- 355
Query: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
++SGSRD T+++WD+ TG CL L+GH VR V + G+ ++S A D ++
Sbjct: 356 -------VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVK 406
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
VWD + + C+ TL H + V SL F +VV+GS+D +++VW+
Sbjct: 407 VWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 163 bits (412), Expect = 3e-40
Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 35/291 (12%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
+VS S+D T+KVW TG RTL GHT V S ++ S S D T+K+W+ +
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWNAETG 451
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
ECI T++GH V + + + +VS SRD T+++W+++TG C+ GH VR V+
Sbjct: 452 ECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ- 508
Query: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
DG + S + D V+VW T+ C L+ H + V + +
Sbjct: 509 -YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF------------------ 549
Query: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
G ++SGS D +I++WDV TG C+ TL GH + G+ ++S D T+
Sbjct: 550 ----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTV 603
Query: 363 RVWDYKNKRCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
++WD K +C++TL N H+ VT L F+K +V+T S D TVK+W+ +
Sbjct: 604 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
Score = 134 bits (336), Expect = 2e-31
Identities = 83/260 (31%), Positives = 136/260 (52%), Gaps = 35/260 (13%)
Query: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
++++S S D T+KVW+ ETG+ TL GHT +V+ + K + S S D T+++WD +
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
Query: 181 GFECIRTMHGHDHNVSSV-AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239
+C+ + GH V++V + +G +VS + D +K+W+ +T C+ T GH R+
Sbjct: 490 TGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RV 544
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
DG + S S D ++RVW V T C L H+ S +G
Sbjct: 545 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-----------------SLTSGM 587
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSC 356
E K + L+SG+ D T+K+WD+ TG CL TL G H + V + F+ F+++
Sbjct: 588 ELKDN-----ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITS 640
Query: 357 ADDKTLRVWDYKNKRCMKTL 376
+DD T+++WD K ++ L
Sbjct: 641 SDDGTVKLWDLKTGEFIRNL 660
Score = 125 bits (315), Expect = 5e-29
Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 33/237 (13%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L GH S V + H +VS S DAT++VWD ETG L GH +V+ + +D
Sbjct: 455 HTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-- 510
Query: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
G+ + S + D +K+WD + C+ T+ GH + V S+ +G H+VS S D +I++W+V
Sbjct: 511 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV 568
Query: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR---EHEHV 278
+TG C+ T TGH+ + + ++ S + D TV++W + T +C L+ +H+
Sbjct: 569 ETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
Query: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335
V C+ + F+++ S D T+K+WD+ TG + LV
Sbjct: 627 VTCLQFNKN----------------------FVITSSDDGTVKLWDLKTGEFIRNLV 661
Score = 123 bits (308), Expect = 3e-28
Identities = 76/225 (33%), Positives = 117/225 (52%), Gaps = 33/225 (14%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHR--EWVRMVRPN 243
+ + GHD +V + + G+ IVS S D T+K+W TG C++T GH W +R N
Sbjct: 374 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 432
Query: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303
+I S S D+T++VW T EC L H V C+ +
Sbjct: 433 ----IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--------------- 473
Query: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
++SGSRD T+++WD+ TG CL L+GH VR V + G+ ++S A D ++
Sbjct: 474 -------VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVK 524
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
VWD + + C+ TL H + V SL F +VV+GS+D +++VW+
Sbjct: 525 VWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 163 bits (412), Expect = 3e-40
Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 35/291 (12%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
+VS S+D T+KVW TG RTL GHT V S ++ S S D T+K+W+ +
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWNAETG 371
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
ECI T++GH V + + + +VS SRD T+++W+++TG C+ GH VR V+
Sbjct: 372 ECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ- 428
Query: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
DG + S + D V+VW T+ C L+ H + V + +
Sbjct: 429 -YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF------------------ 469
Query: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
G ++SGS D +I++WDV TG C+ TL GH + G+ ++S D T+
Sbjct: 470 ----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTV 523
Query: 363 RVWDYKNKRCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
++WD K +C++TL N H+ VT L F+K +V+T S D TVK+W+ +
Sbjct: 524 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLK 572
Score = 134 bits (336), Expect = 2e-31
Identities = 83/260 (31%), Positives = 136/260 (52%), Gaps = 35/260 (13%)
Query: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
++++S S D T+KVW+ ETG+ TL GHT +V+ + K + S S D T+++WD +
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 409
Query: 181 GFECIRTMHGHDHNVSSV-AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239
+C+ + GH V++V + +G +VS + D +K+W+ +T C+ T GH R+
Sbjct: 410 TGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RV 464
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
DG + S S D ++RVW V T C L H+ S +G
Sbjct: 465 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-----------------SLTSGM 507
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSC 356
E K + L+SG+ D T+K+WD+ TG CL TL G H + V + F+ F+++
Sbjct: 508 ELKDN-----ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITS 560
Query: 357 ADDKTLRVWDYKNKRCMKTL 376
+DD T+++WD K ++ L
Sbjct: 561 SDDGTVKLWDLKTGEFIRNL 580
Score = 125 bits (315), Expect = 5e-29
Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 33/237 (13%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L GH S V + H +VS S DAT++VWD ETG L GH +V+ + +D
Sbjct: 375 HTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-- 430
Query: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
G+ + S + D +K+WD + C+ T+ GH + V S+ +G H+VS S D +I++W+V
Sbjct: 431 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV 488
Query: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR---EHEHV 278
+TG C+ T TGH+ + + ++ S + D TV++W + T +C L+ +H+
Sbjct: 489 ETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546
Query: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335
V C+ + F+++ S D T+K+WD+ TG + LV
Sbjct: 547 VTCLQFNKN----------------------FVITSSDDGTVKLWDLKTGEFIRNLV 581
Score = 123 bits (308), Expect = 3e-28
Identities = 76/225 (33%), Positives = 117/225 (52%), Gaps = 33/225 (14%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHR--EWVRMVRPN 243
+ + GHD +V + + G+ IVS S D T+K+W TG C++T GH W +R N
Sbjct: 294 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 352
Query: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303
+I S S D+T++VW T EC L H V C+ +
Sbjct: 353 ----IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--------------- 393
Query: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
++SGSRD T+++WD+ TG CL L+GH VR V + G+ ++S A D ++
Sbjct: 394 -------VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVK 444
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
VWD + + C+ TL H + V SL F +VV+GS+D +++VW+
Sbjct: 445 VWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 157 bits (397), Expect = 2e-38
Identities = 93/305 (30%), Positives = 145/305 (47%), Gaps = 24/305 (7%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
GHR VT V F + S S D+ + VW + GH D+V ++F SG LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 166 ASCSADMTIKLW--DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
AS S D T+++W + +G + H V SV +G V+AS DKT+K+W
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283
+ + + H WVR + + DG LI S S+D+TV++W +++EC EH V +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343
+ P G + + D T+K+WDV T L H V G
Sbjct: 195 FHPS--------------------GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403
+ FH G ++++ + D TL++ D R + TL+ H+ T++ F +T Y +G D+
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
Query: 404 VKVWE 408
V VW+
Sbjct: 295 VMVWK 299
Score = 141 bits (355), Expect = 1e-33
Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 20/269 (7%)
Query: 138 ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197
E ER KGH D+V + F + K LAS S D + +W + GH V+
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 198 VAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257
V P+G + S SRDKT+++W F H VR V DG + S+D+T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
V+VW ++ L +H + V C ++P+ G ++S S D
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--------------------GRLIVSASDD 166
Query: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
KT+K+WD S+ C+ + H +V V FH G I + D T++VWD + R ++
Sbjct: 167 KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
Query: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
H V L FH + Y++T S D T+K+
Sbjct: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 130 bits (327), Expect = 2e-30
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 94 WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
W +P + Y +GH+ VT V F P ++ S S D T+++W + HT +
Sbjct: 46 WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 105
Query: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
V+ + F G+ + S D T+K+W + + ++ H + V P+G IVSAS
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
DKT+K+W+ + CV ++ H +V V + GT IA+ D TV+VW V T
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
+ H V +S+ P +Y L++ S D T+K+ D+ G L
Sbjct: 226 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 265
Query: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
TL GH V F G++ S D+ + VW
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 125 bits (313), Expect = 9e-29
Identities = 70/225 (31%), Positives = 105/225 (46%), Gaps = 20/225 (8%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
R GH V+ V N + S S D + +W ++ FTGH++ V V +
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
G L+AS S D+TVR+WV K R H V + + +
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD------------------ 114
Query: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
G ++ S DKT+K+W L +L H NWVR F G+ I+S +DDKT+++W
Sbjct: 115 --GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
D ++ C+ + H FVT +DFH + + +D TVKVW+ R
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Score = 75.5 bits (184), Expect = 8e-14
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
H VT V FHP + + +A D T+KVWD T + + H+ +V +SF SG L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
+ S+D T+K+ D + T+HGH ++VA G++ S D+ + +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 302
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254
H E ++ RP TL +S N
Sbjct: 303 --DIVDHGEVTKVPRP--PATLASSMGN 326
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 157 bits (397), Expect = 2e-38
Identities = 93/305 (30%), Positives = 145/305 (47%), Gaps = 24/305 (7%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
GHR VT V F + S S D+ + VW + GH D+V ++F SG LL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 166 ASCSADMTIKLW--DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
AS S D T+++W + +G + H V SV +G V+AS DKT+K+W
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTV--FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECIS 283
+ + + H WVR + + DG LI S S+D+TV++W +++EC EH V +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343
+ P G + + D T+K+WDV T L H V G
Sbjct: 195 FHPS--------------------GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234
Query: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403
+ FH G ++++ + D TL++ D R + TL+ H+ T++ F +T Y +G D+
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294
Query: 404 VKVWE 408
V VW+
Sbjct: 295 VMVWK 299
Score = 141 bits (355), Expect = 1e-33
Identities = 82/269 (30%), Positives = 124/269 (46%), Gaps = 20/269 (7%)
Query: 138 ETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSS 197
E ER KGH D+V + F + K LAS S D + +W + GH V+
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 198 VAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQT 257
V P+G + S SRDKT+++W F H VR V DG + S+D+T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 258 VRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRD 317
V+VW ++ L +H + V C ++P+ G ++S S D
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPD--------------------GRLIVSASDD 166
Query: 318 KTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
KT+K+WD S+ C+ + H +V V FH G I + D T++VWD + R ++
Sbjct: 167 KTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ 226
Query: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
H V L FH + Y++T S D T+K+
Sbjct: 227 LHSAAVNGLSFHPSGNYLITASSDSTLKI 255
Score = 130 bits (327), Expect = 2e-30
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 94 WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
W +P + Y +GH+ VT V F P ++ S S D T+++W + HT +
Sbjct: 46 WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 105
Query: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
V+ + F G+ + S D T+K+W + + ++ H + V P+G IVSAS
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165
Query: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
DKT+K+W+ + CV ++ H +V V + GT IA+ D TV+VW V T
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225
Query: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
+ H V +S+ P +Y L++ S D T+K+ D+ G L
Sbjct: 226 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 265
Query: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
TL GH V F G++ S D+ + VW
Sbjct: 266 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 125 bits (313), Expect = 9e-29
Identities = 70/225 (31%), Positives = 105/225 (46%), Gaps = 20/225 (8%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
R GH V+ V N + S S D + +W ++ FTGH++ V V +
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72
Query: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
G L+AS S D+TVR+WV K R H V + + +
Sbjct: 73 GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD------------------ 114
Query: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
G ++ S DKT+K+W L +L H NWVR F G+ I+S +DDKT+++W
Sbjct: 115 --GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Query: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
D ++ C+ + H FVT +DFH + + +D TVKVW+ R
Sbjct: 173 DKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 217
Score = 75.5 bits (184), Expect = 8e-14
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
H VT V FHP + + +A D T+KVWD T + + H+ +V +SF SG L
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
+ S+D T+K+ D + T+HGH ++VA G++ S D+ + +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 302
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254
H E ++ RP TL +S N
Sbjct: 303 --DIVDHGEVTKVPRP--PATLASSMGN 326
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 146 bits (369), Expect = 3e-35
Identities = 84/282 (29%), Positives = 135/282 (47%), Gaps = 24/282 (8%)
Query: 129 DATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW--DFQGFECIR 186
D+ + VW + GH D+V ++F SG LLAS S D T+++W + +G +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV- 60
Query: 187 TMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDG 246
H V SV +G V+AS DKT+K+W + + + H WVR + + DG
Sbjct: 61 -FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 247 TLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGK 306
LI S S+D+TV++W +++EC EH V + + P
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPS------------------- 160
Query: 307 PGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWD 366
G + + D T+K+WDV T L H V G+ FH G ++++ + D TL++ D
Sbjct: 161 -GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Query: 367 YKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
R + TL+ H+ T++ F +T Y +G D+ V VW+
Sbjct: 220 LMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
Score = 130 bits (327), Expect = 2e-30
Identities = 79/273 (28%), Positives = 125/273 (45%), Gaps = 21/273 (7%)
Query: 94 WIPRPPEK-YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
W +P + Y +GH+ VT V F P ++ S S D T+++W + HT +
Sbjct: 8 WHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT 67
Query: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
V+ + F G+ + S D T+K+W + + ++ H + V P+G IVSAS
Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 127
Query: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
DKT+K+W+ + CV ++ H +V V + GT IA+ D TV+VW V T
Sbjct: 128 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 187
Query: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
+ H V +S+ P +Y L++ S D T+K+ D+ G L
Sbjct: 188 QLHSAAVNGLSFHPSGNY--------------------LITASSDSTLKILDLMEGRLLY 227
Query: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
TL GH V F G++ S D+ + VW
Sbjct: 228 TLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 115 bits (288), Expect = 7e-26
Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 20/198 (10%)
Query: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
D + +W ++ FTGH++ V V + G L+AS S D+TVR+WV K
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
R H V + + + G ++ S DKT+K+W L
Sbjct: 62 RAHTATVRSVHFCSD--------------------GQSFVTASDDKTVKVWATHRQKFLF 101
Query: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTA 392
+L H NWVR F G+ I+S +DDKT+++WD ++ C+ + H FVT +DFH +
Sbjct: 102 SLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG 161
Query: 393 PYVVTGSVDQTVKVWECR 410
+ +D TVKVW+ R
Sbjct: 162 TCIAAAGMDNTVKVWDVR 179
Score = 75.5 bits (184), Expect = 8e-14
Identities = 45/148 (30%), Positives = 71/148 (47%), Gaps = 7/148 (4%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
H VT V FHP + + +A D T+KVWD T + + H+ +V +SF SG L
Sbjct: 148 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 207
Query: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
+ S+D T+K+ D + T+HGH ++VA G++ S D+ + +W+
Sbjct: 208 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNF--- 264
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSN 254
H E ++ RP TL +S N
Sbjct: 265 --DIVDHGEVTKVPRP--PATLASSMGN 288
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 145 bits (365), Expect = 8e-35
Identities = 84/300 (28%), Positives = 138/300 (46%), Gaps = 24/300 (8%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
H V F P ++++ SED + W+ +G L GHT V+ F G L A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
S S D T++LWD +C+R + GH +V +V+ P+ + S DK + +W+VQ+G
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW---VVATKECKAELREHEHVVECIS 283
++ GHR+ ++ + +A+ S D TV +W +V L H + C+
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 284 WAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG 343
++ A+G L SGS DKTI +W +T L+ L GH WV+
Sbjct: 200 YS----------ASG-----------LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238
Query: 344 VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 403
+ F ++ S + ++VWD +C++TL + F +V+G+ DQT
Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 117 bits (293), Expect = 2e-26
Identities = 77/265 (29%), Positives = 121/265 (45%), Gaps = 24/265 (9%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L GH PV F P + SAS D T+++WD R LKGH SV+ +SF
Sbjct: 57 WRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPD 116
Query: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE- 220
+ LAS D + LWD Q + +R + GH ++ S P + + + S D T+ +W+
Sbjct: 117 SRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Query: 221 --VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
V + GH + + + G L+AS S D+T+ +W T +L+ H
Sbjct: 177 RMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTW 235
Query: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
V+ I+++P+ + L S + +K+WD +TG CL TL G
Sbjct: 236 VKSIAFSPDELW--------------------LASAGYSRMVKVWDCNTGKCLETLKGVL 275
Query: 339 NWVRGVLFHSGGKFILSCADDKTLR 363
+ F GK ++S A D+T R
Sbjct: 276 DVAHTCAFTPDGKILVSGAADQTRR 300
Score = 95.1 bits (235), Expect = 1e-19
Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 64/263 (24%)
Query: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
H V+S A P+G +++ S D + WE ++G + GH V+ R + DG L A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
S S D TVR+W VA +C L+ H+ VE +S++P+S
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ-------------------- 119
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRG--------------------------- 343
L SG DK + +WDV +G L LVGH + ++
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 344 -----------------VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386
L +S + S + DKT+ +W + L H +V S+
Sbjct: 180 TPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSI 239
Query: 387 DFHKTAPYVVTGSVDQTVKVWEC 409
F ++ + + VKVW+C
Sbjct: 240 AFSPDELWLASAGYSRMVKVWDC 262
Score = 74.3 bits (181), Expect = 2e-13
Identities = 50/184 (27%), Positives = 77/184 (41%), Gaps = 20/184 (10%)
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286
VK F H V + DG ++ + S D V W + + L H V+ ++P
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 287 ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLF 346
+ G S S D T+++WDV+ CL L GH V V F
Sbjct: 74 D--------------------GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF 113
Query: 347 HSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
+ + S DK + +WD ++ + ++ L H + S DF T + TGS D TV +
Sbjct: 114 SPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHI 173
Query: 407 WECR 410
W+ R
Sbjct: 174 WDLR 177
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 142 bits (359), Expect = 4e-34
Identities = 83/308 (26%), Positives = 133/308 (43%), Gaps = 21/308 (6%)
Query: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFD 159
E+Y GH++ +T + P + +AS D + +W+++ GH D V + F
Sbjct: 11 ERY-FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFS 69
Query: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
G LLAS S D T++LW H V SV +G + +AS DK+IK+W
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 220 EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVV 279
+ + + H WVR + + DG LI SCS D+T+++W K+C +
Sbjct: 130 SMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFA 189
Query: 280 ECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDN 339
+ + P G + S D+T+K+WDV L H
Sbjct: 190 NFVDFNPS--------------------GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
Query: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGS 399
V + FH G ++++ + D TL++ D R + TL H V ++ F K +G
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
Query: 400 VDQTVKVW 407
D V +W
Sbjct: 290 ADTQVLLW 297
Score = 139 bits (350), Expect = 5e-33
Identities = 82/284 (28%), Positives = 132/284 (46%), Gaps = 30/284 (10%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
M SA+ED + ER KGH ++ + +GK LA+ S D + LW+F+
Sbjct: 1 MASATEDPVL----------ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPH 50
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242
GH V+SV P+G+ + SASRD+T+++W F H VR V
Sbjct: 51 ARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF 110
Query: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
+ DG +A+ S D++++VW + + L H H V C ++P+
Sbjct: 111 SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPD--------------- 155
Query: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362
G ++S S DKTIK+WD + C+ + V F+ G I S D+T+
Sbjct: 156 -----GRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTV 210
Query: 363 RVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
+VWD + + ++ H V + FH + Y++T S D T+K+
Sbjct: 211 KVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 131 bits (329), Expect = 1e-30
Identities = 67/225 (29%), Positives = 114/225 (50%), Gaps = 20/225 (8%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
R GH ++S+ + PNG + +AS D + +W + + GH++ V V+ +
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
G L+AS S D+TVR+W+ + +E + H V + ++ +
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD------------------ 113
Query: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
G FL + S DK+IK+W + L +L H +WVR F G+ I+SC++DKT+++W
Sbjct: 114 --GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 366 DYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
D NK+C+ + F +DF+ + + + DQTVKVW+ R
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 134 bits (338), Expect = 1e-31
Identities = 93/337 (27%), Positives = 155/337 (45%), Gaps = 30/337 (8%)
Query: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
+L GH V V F P + S S D T++ WD T T KGH V IS+ G
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 163 KLLASCSADMTIKLWD-FQGFECIRTMHGHDHNVSSVA-----IMPNGDHIVSASRDKTI 216
+ LAS + I LWD G + RT+ GH ++ ++ P ++ S+S+D ++
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 217 KMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHE 276
++W+ G C + TGH + V +R DG L+ S S D+T++VW L+ H
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHG 287
Query: 277 HVVECISWA------------------PESSYSSISE----ATGSETKKSGKPGPFLLSG 314
H V ++ + P+ S+ E A G+ L+SG
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
Query: 315 SRDKTIKMWDVSTGMCLMT-LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
S D T+ +W + +T + GH + VLF + + S + DK++++WD + + +
Sbjct: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
Query: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
+L H V + + + +V+GS D T+KVW+ +
Sbjct: 408 ASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK 444
Score = 120 bits (302), Expect = 2e-27
Identities = 88/336 (26%), Positives = 149/336 (44%), Gaps = 32/336 (9%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFD- 159
+ GHR V + + P + S ++ I +WD TG RTL GH+ + +S++
Sbjct: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
Query: 160 -HSG---KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDK 214
H+ + +AS S D ++++WD C R + GH +V+ + GD ++ SAS+D+
Sbjct: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVT--CLRWGGDGLLYSASQDR 267
Query: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
TIK+W G +T GH WV + + D L V + EL+E
Sbjct: 268 TIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE 327
Query: 275 H-------------EHVVE------CISWAPESSYSSISEATGSETKKS----GKPGPFL 311
E +V W+P ++ TG + + +
Sbjct: 328 RALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIV 387
Query: 312 LSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 371
S S DK+IK+WD TG L +L GH V + + + + ++S + D TL+VWD K ++
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQK 447
Query: 372 CMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
L H V ++D+ V +G D+ +++W
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 95.9 bits (237), Expect = 6e-20
Identities = 59/205 (28%), Positives = 95/205 (46%), Gaps = 19/205 (9%)
Query: 184 CIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPN 243
C ++ GH V SVA P G ++ S S D T++ W++ T T GHR WV + +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 244 QDGTLIAS-CSNDQTVRVWVVAT-KECKAELREHEHVVECISWAPESSYSSISEATGSET 301
DG +AS C N Q + +W +T K+ L H + +SW P +
Sbjct: 166 PDGRKLASGCKNGQ-ILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR------- 217
Query: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
++ S S+D ++++WD + G C L GH V L G + S + D+T
Sbjct: 218 --------YVASSSKDGSVRIWDTTAGRCERILTGHTQSVT-CLRWGGDGLLYSASQDRT 268
Query: 362 LRVWDYKNKRCMKTLNAHEHFVTSL 386
++VW + +TL H H+V ++
Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTM 293
Score = 91.3 bits (225), Expect = 1e-18
Identities = 50/167 (29%), Positives = 87/167 (52%), Gaps = 14/167 (8%)
Query: 67 ELESKLNEAKEEFTSGGPLGQKRDPKE------------WIPRPPEK--YALSGHRSPVT 112
+L+ L E KE S L + + P+ W P +K ++GH++ +
Sbjct: 317 DLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALIN 376
Query: 113 RVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADM 172
+V+F P ++ SAS D +IK+WD TG + +L+GH +V I++ +LL S S+D
Sbjct: 377 QVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDS 436
Query: 173 TIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
T+K+WD + + + GH V +V P+G + S +DK +++W
Sbjct: 437 TLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 46.2 bits (108), Expect = 5e-05
Identities = 22/79 (27%), Positives = 37/79 (46%)
Query: 330 CLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389
C +L GH V V F GK++ S + D T+R WD + T H H+V S+ +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWS 165
Query: 390 KTAPYVVTGSVDQTVKVWE 408
+ +G + + +W+
Sbjct: 166 PDGRKLASGCKNGQILLWD 184
Score = 36.2 bits (82), Expect = 0.055
Identities = 15/38 (39%), Positives = 21/38 (55%)
Query: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
RC +L H V S+ F T Y+ +GS D TV+ W+
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWD 142
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 131 bits (330), Expect = 1e-30
Identities = 99/324 (30%), Positives = 141/324 (43%), Gaps = 42/324 (12%)
Query: 104 LSGHRSPVTRVIFHPVFSVMV-SASEDATIKVW-----DYETGDFERTLKGHTDSVQDIS 157
L GH VT++ P F M+ SAS D TI +W + G +R L+GH+ V D+
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVV 70
Query: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
G+ S S D T++LWD R GH +V SVA + IVS SRDKTIK
Sbjct: 71 ISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIK 130
Query: 218 MWEVQTGYCVKTF--TGHREWVRMVR--PNQDGTLIASCSNDQTVRVWVVATKECKAELR 273
+W G C T H EWV VR PN +I SC D+ V+VW +A + K
Sbjct: 131 LWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHI 189
Query: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
H + ++ +P+ G SG +D +WD++ G L T
Sbjct: 190 GHTGYLNTVTVSPD--------------------GSLCASGGKDGQAMLWDLNEGKHLYT 229
Query: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL---------NAHEHFVT 384
L G D + L S ++ L A ++++WD + K + L A T
Sbjct: 230 LDGGD--IINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT 287
Query: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408
SL + + G D V+VW+
Sbjct: 288 SLAWSADGQTLFAGYTDNLVRVWQ 311
Score = 86.3 bits (212), Expect = 5e-17
Identities = 54/163 (33%), Positives = 76/163 (46%), Gaps = 5/163 (3%)
Query: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
AL GH V+ V+ +S S D T+++WD TG R GHT V ++F
Sbjct: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117
Query: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHN--VSSVAIMPNGDH--IVSASRDKTIKM 218
+ + S S D TIKLW+ G C T+ H+ VS V PN + IVS DK +K+
Sbjct: 118 RQIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176
Query: 219 WEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
W + GH ++ V + DG+L AS D +W
Sbjct: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 130 bits (328), Expect = 2e-30
Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 29/311 (9%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSV--------QDIS 157
G P++ F P ++ +A K+W + TL+GH +V +S
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
D LASC+AD ++KLW E + + GH V+ V P+G + + D++ +
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
+W+++ + GH V + +QDG+L + D RVW + T C L H
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK 408
Query: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH 337
+ I+++P G + +GS D T K+WD+ C+ T+ H
Sbjct: 409 EIYGINFSPN--------------------GYHIATGSGDNTCKVWDLRQRRCVYTIPAH 448
Query: 338 DNWVRGVLFHS-GGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
N V GV F G F+L+ A D T ++W + +KTL HE V LD +
Sbjct: 449 QNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIA 508
Query: 397 TGSVDQTVKVW 407
T S D+T K+W
Sbjct: 509 TCSYDRTFKLW 519
Score = 126 bits (316), Expect = 4e-29
Identities = 72/272 (26%), Positives = 129/272 (47%), Gaps = 27/272 (9%)
Query: 102 YALSGHRSPVTRVIFHPVFSV--------MVSASEDATIKVWDYETGDFERTLKGHTDSV 153
+ L GH + V ++FHP +V + S + D ++K+W ++ + ++GHT V
Sbjct: 267 HTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRV 326
Query: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRD 213
+ + SG+ L + D + +LWD + E I GH V +A +G + D
Sbjct: 327 ARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLD 386
Query: 214 KTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR 273
++W+++TG C+ GH + + + + +G IA+ S D T +VW + + C +
Sbjct: 387 AFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP 446
Query: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
H+++V + + P G FLL+G+ D T K+W L T
Sbjct: 447 AHQNLVTGVKFEPIH-------------------GNFLLTGAYDNTAKIWTHPGWSPLKT 487
Query: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
L GH+ V G+ S G+ I +C+ D+T ++W
Sbjct: 488 LAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 93.6 bits (231), Expect = 3e-19
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 1/158 (0%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
GH V + FH S+ + DA +VWD TG L+GH + I+F +G +
Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHI 422
Query: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMWEVQTG 224
A+ S D T K+WD + C+ T+ H + V+ V P +G+ +++ + D T K+W
Sbjct: 423 ATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGW 482
Query: 225 YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWV 262
+KT GH V + + DG LIA+CS D+T ++W+
Sbjct: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWM 520
Score = 83.6 bits (205), Expect = 3e-16
Identities = 57/229 (24%), Positives = 93/229 (40%), Gaps = 28/229 (12%)
Query: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL- 248
G D +S PN + +A K+W V + T GH V + + T+
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 249 -------IASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
+ASC+ D +V++W + + E A++ H V + W P
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS-------------- 334
Query: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
G FL + D++ ++WD+ ++ GH V + FH G + D
Sbjct: 335 ------GRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAF 388
Query: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
RVWD + RC+ L H + ++F ++ TGS D T KVW+ R
Sbjct: 389 GRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 129 bits (324), Expect = 5e-30
Identities = 87/298 (29%), Positives = 144/298 (48%), Gaps = 44/298 (14%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
+VS D TIK+WD T + +R L GHT SV + +D +++ + S+D T+++WD
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTG 337
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
E + T+ H V + N +V+ S+D++I +W++ + + + GHR V +
Sbjct: 338 EMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 395
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 396 V--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR------------ 441
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 442 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 489
Query: 360 KTLRVWDY---------KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++VWD C++TL H V L F + +V+ S D T+ +W+
Sbjct: 490 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWD 545
Score = 115 bits (288), Expect = 7e-26
Identities = 83/281 (29%), Positives = 135/281 (48%), Gaps = 44/281 (15%)
Query: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
K L+GH V + + V+++ S D+T++VWD TG+ TL H ++V + F++
Sbjct: 300 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN 357
Query: 161 SGKLLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
++ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK
Sbjct: 358 G--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 413
Query: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
+W T V+T GH+ + ++ L+ S S+D T+R+W + C L HE
Sbjct: 414 VWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEE 471
Query: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG--------- 328
+V CI + + K+ ++SG+ D IK+WD+
Sbjct: 472 LVRCIRF---------------DNKR-------IVSGAYDGKIKVWDLVAALDPRAPAGT 509
Query: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
+CL TLV H V + F I+S + D T+ +WD+ N
Sbjct: 510 LCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWDFLN 548
Score = 75.1 bits (183), Expect = 1e-13
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 29/166 (17%)
Query: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
D I S D T+++W T ECK L H V C+ +
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER----------------- 318
Query: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
+++GS D T+++WDV+TG L TL+ H V + F++G +++C+ D+++ V
Sbjct: 319 -----VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAV 371
Query: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 372 WDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 415
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 129 bits (324), Expect = 5e-30
Identities = 87/298 (29%), Positives = 144/298 (48%), Gaps = 44/298 (14%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
+VS D TIK+WD T + +R L GHT SV + +D +++ + S+D T+++WD
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTG 373
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
E + T+ H V + N +V+ S+D++I +W++ + + + GHR V +
Sbjct: 374 EMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV 431
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 432 V--DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDR------------ 477
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 478 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 525
Query: 360 KTLRVWDY---------KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++VWD C++TL H V L F + +V+ S D T+ +W+
Sbjct: 526 GKIKVWDLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWD 581
Score = 115 bits (288), Expect = 7e-26
Identities = 83/281 (29%), Positives = 135/281 (48%), Gaps = 44/281 (15%)
Query: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
K L+GH V + + V+++ S D+T++VWD TG+ TL H ++V + F++
Sbjct: 336 KRILTGHTGSVLCLQYDE--RVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNN 393
Query: 161 SGKLLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
++ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK
Sbjct: 394 G--MMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIK 449
Query: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
+W T V+T GH+ + ++ L+ S S+D T+R+W + C L HE
Sbjct: 450 VWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEE 507
Query: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG--------- 328
+V CI + + K+ ++SG+ D IK+WD+
Sbjct: 508 LVRCIRF---------------DNKR-------IVSGAYDGKIKVWDLVAALDPRAPAGT 545
Query: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
+CL TLV H V + F I+S + D T+ +WD+ N
Sbjct: 546 LCLRTLVEHSGRVFRLQFDEFQ--IVSSSHDDTILIWDFLN 584
Score = 75.1 bits (183), Expect = 1e-13
Identities = 48/166 (28%), Positives = 78/166 (46%), Gaps = 29/166 (17%)
Query: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
D I S D T+++W T ECK L H V C+ +
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDER----------------- 354
Query: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
+++GS D T+++WDV+TG L TL+ H V + F++G +++C+ D+++ V
Sbjct: 355 -----VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNG--MMVTCSKDRSIAV 407
Query: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 408 WDMASPTDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 451
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 129 bits (323), Expect = 6e-30
Identities = 87/323 (26%), Positives = 143/323 (44%), Gaps = 30/323 (9%)
Query: 93 EWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
+W P +SGH V + P V+ S D TIK+WD +G + +L GH +
Sbjct: 189 QWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIST 248
Query: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
V+ + L SC D +K WD + + IR HGH V + + P D +V+ SR
Sbjct: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308
Query: 213 DKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
D T ++W+V+T V T +GH V VR I + S+D T+R+W + + + L
Sbjct: 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL 368
Query: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM 332
H+ V + P T SG P IK W G +
Sbjct: 369 TNHKKSVRAVVLHPR-----------HYTFASGSP----------DNIKQWKFPDGSFIQ 407
Query: 333 TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA--------HEHFVT 384
L GH+ + + +S G ++S AD+ T+ +WD++ + ++A E +
Sbjct: 408 NLSGHNAIINTLTVNSDG-VLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIF 466
Query: 385 SLDFHKTAPYVVTGSVDQTVKVW 407
+ F ++ ++T D+T+KV+
Sbjct: 467 ACAFDQSESRLLTAEADKTIKVY 489
Score = 86.7 bits (213), Expect = 4e-17
Identities = 46/181 (25%), Positives = 82/181 (45%), Gaps = 20/181 (11%)
Query: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPE 287
+ +GH WVR + + S D+T+++W +A+ + K L H V + +
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257
Query: 288 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFH 347
S P+L S DK +K WD+ + GH + V G+ H
Sbjct: 258 S--------------------PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLH 297
Query: 348 SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
+++C+ D T R+WD + K + TL+ H + V ++ P ++TGS D T+++W
Sbjct: 298 PTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLW 357
Query: 408 E 408
+
Sbjct: 358 D 358
Score = 84.0 bits (206), Expect = 2e-16
Identities = 42/126 (33%), Positives = 71/126 (56%), Gaps = 1/126 (0%)
Query: 286 PESSYSSISEATGSETKKSGKPG-PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV 344
P Y IS G + +PG + ++GS D+TIK+WD+++G ++L GH + VRGV
Sbjct: 193 PWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGV 252
Query: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404
+ + ++ SC +DK ++ WD + + ++ + H V LD H T +VT S D T
Sbjct: 253 IVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTA 312
Query: 405 KVWECR 410
++W+ R
Sbjct: 313 RIWDVR 318
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 126 bits (316), Expect = 4e-29
Identities = 68/251 (27%), Positives = 124/251 (49%), Gaps = 21/251 (8%)
Query: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181
++ + +D + +W + +L GHT V+ + + +L+ + S +I++WD +
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241
+ +RT+ GH N+ S+ P G+ + S S+D IK+W+++ CV + GH + VR +R
Sbjct: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
Query: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
+ DG +AS ++D TV++W + + +E H V + + P
Sbjct: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY------------ 202
Query: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
L SGS D+TI+ WD+ + + G VR VLF+ G + S D +
Sbjct: 203 --------LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-S 253
Query: 362 LRVWDYKNKRC 372
LRV+ ++ +RC
Sbjct: 254 LRVYGWEPERC 264
Score = 113 bits (282), Expect = 4e-25
Identities = 64/192 (33%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ 154
I +P +L+GH SPV V + ++V+ S+ +I+VWD E RTL GH ++
Sbjct: 50 INKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC 109
Query: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
+ F G+ +AS S D IKLWD + C+ GH V + P+G + SA+ D
Sbjct: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
Query: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
T+K+W++ G + F GH V +V + + L+AS S+D+T+R W + E
Sbjct: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL----------E 219
Query: 275 HEHVVECISWAP 286
VV CI P
Sbjct: 220 KFQVVSCIEGEP 231
Score = 110 bits (275), Expect = 2e-24
Identities = 65/249 (26%), Positives = 114/249 (45%), Gaps = 21/249 (8%)
Query: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
SG+LLA+ D + LW CI ++ GH V SV + + IV+ S+ +I++W+
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
++ ++T GH+ + + + G +AS S D +++W + K C R H V
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
C+ ++P+ G +L S + D T+K+WD++ G + GH
Sbjct: 152 CLRFSPD--------------------GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
Query: 341 VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSV 400
V V FH + S + D+T+R WD + + + + V S+ F+ + +G
Sbjct: 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQ 251
Query: 401 DQ-TVKVWE 408
D V WE
Sbjct: 252 DSLRVYGWE 260
Score = 91.7 bits (226), Expect = 1e-18
Identities = 52/159 (32%), Positives = 77/159 (48%), Gaps = 1/159 (0%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L GH++ + + FHP + S S+D IK+WD +GH+ +V+ + F GK
Sbjct: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
Query: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
LAS + D T+KLWD + + GH V+ V PN + S S D+TI+ W+++
Sbjct: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
Query: 224 GYCVKTFTGHREWVRMVRPNQDG-TLIASCSNDQTVRVW 261
V G VR V N DG L + C + V W
Sbjct: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGW 259
Score = 79.7 bits (195), Expect = 4e-15
Identities = 51/192 (26%), Positives = 80/192 (41%), Gaps = 22/192 (11%)
Query: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATG 298
+V G L+A+ +D V +W + C L H VE + +G
Sbjct: 26 LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85
Query: 299 S------ETKKSGKP----------------GPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
S E K + G F+ SGS+D IK+WD+ C+ G
Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG 145
Query: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVV 396
H VR + F GK++ S ADD T+++WD + M H V ++FH +
Sbjct: 146 HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 397 TGSVDQTVKVWE 408
+GS D+T++ W+
Sbjct: 206 SGSSDRTIRFWD 217
Score = 74.7 bits (182), Expect = 1e-13
Identities = 32/103 (31%), Positives = 59/103 (57%)
Query: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
G L +G D + +W ++ C+M+L GH + V V ++ + I++ + ++RVWD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
+ + ++TL H+ + SLDFH +V +GS D +K+W+ R
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Score = 38.9 bits (89), Expect = 0.009
Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 1/83 (1%)
Query: 327 TGMCLMTLVGHDNWVRG-VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTS 385
T L +V H + V VL + G+ + + DD + +W C+ +L H V S
Sbjct: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68
Query: 386 LDFHKTAPYVVTGSVDQTVKVWE 408
+ + +V GS +++VW+
Sbjct: 69 VRLNTPEELIVAGSQSGSIRVWD 91
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 124 bits (312), Expect = 1e-28
Identities = 83/298 (27%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
++S D +IK+WD + + + L GHT SV + +D +++ + S+D T+++WD
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTG 310
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
E + T+ H+ V + NG +V+ S+D++I +W++ + + + GHR V +
Sbjct: 311 EVLNTLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 368
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 369 V--DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR------------ 414
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 415 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 462
Query: 360 KTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++VWD + + C++TL H V L F + +++ S D T+ +W+
Sbjct: 463 GKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWD 518
Score = 117 bits (294), Expect = 1e-26
Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L+GH V + + V+V+ S D+T++VWD TG+ TL H ++V + F S
Sbjct: 276 LTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNG 331
Query: 164 LLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
L+ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK+W
Sbjct: 332 LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 389
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
T V+T GH+ + ++ L+ S S+D T+R+W + C L HE +V
Sbjct: 390 TSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR 447
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---------STGMCL 331
CI + + K+ ++SG+ D IK+WD+ ++ +CL
Sbjct: 448 CIRF---------------DNKR-------IVSGAYDGKIKVWDLQAALDPRAPASTLCL 485
Query: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
TLV H V + F I+S + D T+ +WD+ N
Sbjct: 486 RTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLN 521
Score = 89.7 bits (221), Expect = 4e-18
Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
+ I+S RD +IK+W+ + C+K TGH V ++ D +I + S+D TVRVW V
Sbjct: 251 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVN 308
Query: 265 TKECKAELREHEHVV--------ECISWAPESSYSSISEATGSE-TKKSGKPG------- 308
T E L H V ++ + + S + A+ ++ T + G
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 368
Query: 309 -----PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
+++S S D+TIK+W ST + TL GH + + + + ++S + D T+R
Sbjct: 369 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIR 426
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
+WD + C++ L HE V + F +V+G+ D +KVW+
Sbjct: 427 LWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWD 469
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 29/166 (17%)
Query: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
D I S D ++++W + EC L H V C+ +
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------- 291
Query: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
+++GS D T+++WDV+TG L TL+ H+ V + F +G +++C+ D+++ V
Sbjct: 292 -----VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAV 344
Query: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 345 WDMASATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 388
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 124 bits (312), Expect = 1e-28
Identities = 83/298 (27%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
++S D +IK+WD + + + L GHT SV + +D +++ + S+D T+++WD
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTG 276
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
E + T+ H+ V + NG +V+ S+D++I +W++ + + + GHR V +
Sbjct: 277 EVLNTLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 335 V--DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR------------ 380
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 381 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 428
Query: 360 KTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++VWD + + C++TL H V L F + +++ S D T+ +W+
Sbjct: 429 GKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWD 484
Score = 117 bits (294), Expect = 1e-26
Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L+GH V + + V+V+ S D+T++VWD TG+ TL H ++V + F S
Sbjct: 242 LTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNG 297
Query: 164 LLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
L+ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK+W
Sbjct: 298 LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 355
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
T V+T GH+ + ++ L+ S S+D T+R+W + C L HE +V
Sbjct: 356 TSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR 413
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---------STGMCL 331
CI + + K+ ++SG+ D IK+WD+ ++ +CL
Sbjct: 414 CIRF---------------DNKR-------IVSGAYDGKIKVWDLQAALDPRAPASTLCL 451
Query: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
TLV H V + F I+S + D T+ +WD+ N
Sbjct: 452 RTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLN 487
Score = 89.7 bits (221), Expect = 4e-18
Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
+ I+S RD +IK+W+ + C+K TGH V ++ D +I + S+D TVRVW V
Sbjct: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVN 274
Query: 265 TKECKAELREHEHVV--------ECISWAPESSYSSISEATGSE-TKKSGKPG------- 308
T E L H V ++ + + S + A+ ++ T + G
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 334
Query: 309 -----PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
+++S S D+TIK+W ST + TL GH + + + + ++S + D T+R
Sbjct: 335 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIR 392
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
+WD + C++ L HE V + F +V+G+ D +KVW+
Sbjct: 393 LWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWD 435
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 29/166 (17%)
Query: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
D I S D ++++W + EC L H V C+ +
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------- 257
Query: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
+++GS D T+++WDV+TG L TL+ H+ V + F +G +++C+ D+++ V
Sbjct: 258 -----VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAV 310
Query: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 311 WDMASATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 354
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 124 bits (312), Expect = 1e-28
Identities = 83/298 (27%), Positives = 147/298 (49%), Gaps = 44/298 (14%)
Query: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182
++S D +IK+WD + + + L GHT SV + +D +++ + S+D T+++WD
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTG 297
Query: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV---KTFTGHREWVRM 239
E + T+ H+ V + NG +V+ S+D++I +W++ + + + GHR V +
Sbjct: 298 EVLNTLIHHNEAVLHLRFS-NG-LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355
Query: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299
V + D I S S D+T++VW +T E L H+ + C+ +
Sbjct: 356 V--DFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDR------------ 401
Query: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADD 359
++SGS D TI++WD+ G CL L GH+ VR + F + K I+S A D
Sbjct: 402 ----------LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDN--KRIVSGAYD 449
Query: 360 KTLRVWDYK---------NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++VWD + + C++TL H V L F + +++ S D T+ +W+
Sbjct: 450 GKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWD 505
Score = 117 bits (294), Expect = 1e-26
Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L+GH V + + V+V+ S D+T++VWD TG+ TL H ++V + F S
Sbjct: 263 LTGHTGSVLCLQYDE--RVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNG 318
Query: 164 LLASCSADMTIKLWDFQGFECI---RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
L+ +CS D +I +WD I R + GH V+ V + +IVSAS D+TIK+W
Sbjct: 319 LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWS 376
Query: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
T V+T GH+ + ++ L+ S S+D T+R+W + C L HE +V
Sbjct: 377 TSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVR 434
Query: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV---------STGMCL 331
CI + + K+ ++SG+ D IK+WD+ ++ +CL
Sbjct: 435 CIRF---------------DNKR-------IVSGAYDGKIKVWDLQAALDPRAPASTLCL 472
Query: 332 MTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
TLV H V + F I+S + D T+ +WD+ N
Sbjct: 473 RTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWDFLN 508
Score = 89.7 bits (221), Expect = 4e-18
Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 27/225 (12%)
Query: 205 DHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
+ I+S RD +IK+W+ + C+K TGH V ++ D +I + S+D TVRVW V
Sbjct: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSSDSTVRVWDVN 295
Query: 265 TKECKAELREHEHVV--------ECISWAPESSYSSISEATGSE-TKKSGKPG------- 308
T E L H V ++ + + S + A+ ++ T + G
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNV 355
Query: 309 -----PFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363
+++S S D+TIK+W ST + TL GH + + + + ++S + D T+R
Sbjct: 356 VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIR 413
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
+WD + C++ L HE V + F +V+G+ D +KVW+
Sbjct: 414 LWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWD 456
Score = 70.5 bits (171), Expect = 3e-12
Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 29/166 (17%)
Query: 245 DGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKS 304
D I S D ++++W + EC L H V C+ +
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER----------------- 278
Query: 305 GKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRV 364
+++GS D T+++WDV+TG L TL+ H+ V + F +G +++C+ D+++ V
Sbjct: 279 -----VIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAV 331
Query: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
WD + + L H V +DF Y+V+ S D+T+KVW
Sbjct: 332 WDMASATDITLRRVLVGHRAAVNVVDFDD--KYIVSASGDRTIKVW 375
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 120 bits (300), Expect = 3e-27
Identities = 72/260 (27%), Positives = 123/260 (47%), Gaps = 21/260 (8%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
GH ++ FHP + ++S D T+K+WD GD T +GH+ +V ++ G +
Sbjct: 392 GHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFV 451
Query: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
AS S D T K+WD C T++GH +V+S+ P + ++++S DKT+ +W+ +TG
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
Query: 226 CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWA 285
C ++ GH + + G +IASC ++W + R+ +V
Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW---------DFRKLLPIVSI---- 558
Query: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVL 345
I + G+E G L S + I + D+ +G + L+GH+N V+
Sbjct: 559 ------DIGPSPGNEVNFDSS-GRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVV 610
Query: 346 FHSGGKFILSCADDKTLRVW 365
F G+ + S D T+R W
Sbjct: 611 FSHDGEILFSGGSDGTVRTW 630
Score = 108 bits (271), Expect = 7e-24
Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 20/220 (9%)
Query: 149 HTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV 208
H V +S +L SC D K+ + T GH +S P+GD +
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 209 SASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC 268
++S D T+K+W++ G C+ TF GH V + G +AS S D+T ++W V ++ C
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Query: 269 KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTG 328
+ L H V I + P S+ LL+ S DKT+ +WD TG
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSN--------------------TLLTSSADKTLSIWDARTG 510
Query: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
+C +L GH + + +F G I SC ++WD++
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
Score = 95.5 bits (236), Expect = 8e-20
Identities = 58/220 (26%), Positives = 95/220 (43%), Gaps = 20/220 (9%)
Query: 191 HDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
H+ VS V++ P+ D +VS D+ K+ + + T GH +W+ + G +A
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
+ S D TV++W + +C H V +W G F
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWH--------------------SCGNF 450
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
+ S S DKT K+WDV++ C TL GH + V + F +L+ + DKTL +WD +
Sbjct: 451 VASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Query: 371 RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
C ++L H H + F + + K+W+ R
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFR 550
Score = 84.7 bits (208), Expect = 1e-16
Identities = 49/158 (31%), Positives = 79/158 (50%), Gaps = 1/158 (0%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
L GH V + F P + ++++S D T+ +WD TG E++L GH S+ D FD G
Sbjct: 474 LYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGH 533
Query: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
++ASC A KLWDF+ I ++ + V +G + AS + I + ++++
Sbjct: 534 MIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKS 593
Query: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
G + GH V + DG ++ S +D TVR W
Sbjct: 594 GE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 50.8 bits (120), Expect = 2e-06
Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 1/117 (0%)
Query: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
+L GH + IF P ++ S K+WD+ ++ +++FD SG
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
Query: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 219
++LA S + I L D + E I + GH++ +V +G+ + S D T++ W
Sbjct: 575 RVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 119 bits (298), Expect = 5e-27
Identities = 86/315 (27%), Positives = 145/315 (46%), Gaps = 31/315 (9%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-YETGDFERTLKGHTDSVQDISFDHSG 162
LSGH V FHP S + SA D I +W+ Y D TLKGH+ +V ++ ++ G
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
Query: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDKTIKMWEV 221
+L S S D T+ +WD + E ++ + GH V+S G +V + S D T+K+W++
Sbjct: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
Query: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
+ ++TF + V V N I S D ++VW + + +R H V
Sbjct: 182 RKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV----STGMCLMTLVGH 337
+S + E SY LLS + D T+++WDV C+ G+
Sbjct: 241 LSLSSEGSY--------------------LLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
Query: 338 -DNWVRGVL---FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAP 393
N+ + +L + G I + + D+ + VWD ++R + L H + + FH P
Sbjct: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
Query: 394 YVVTGSVDQTVKVWE 408
+++ S D+ + + E
Sbjct: 341 IIISASSDKRLYMGE 355
Score = 96.7 bits (239), Expect = 3e-20
Identities = 68/229 (29%), Positives = 102/229 (44%), Gaps = 25/229 (10%)
Query: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMVRP 242
I + GH+ V PNG + SA D+ I +W V G C T GH V +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHY 117
Query: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
N DG+++ S S D+TV VW T E L+ H V S Y +
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN-------SCYPA---------- 160
Query: 303 KSGKPGPFLL-SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
+ GP L+ +GS D T+K+WD+ + T + V V F+ I+S D
Sbjct: 161 ---RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
Query: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
++VWD + + T+ H VT L Y+++ ++D TV+VW+ R
Sbjct: 217 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 12/179 (6%)
Query: 53 KKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPE-KYALSGHRSPV 111
+K ++ Q L N+ ++ SGG D K W R + Y + GH V
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI---DNDIKVWDLRQNKLTYTMRGHADSV 238
Query: 112 TRVIFHPVFSVMVSASEDATIKVWDYET-GDFERTLKGHTDSVQDI-------SFDHSGK 163
T + S ++S + D T++VWD ER +K +V + S+ G
Sbjct: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
Query: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
+A+ SAD + +WD + + GH +++ VA P+ I+SAS DK + M E+Q
Sbjct: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 118 bits (295), Expect = 1e-26
Identities = 74/279 (26%), Positives = 127/279 (45%), Gaps = 20/279 (7%)
Query: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
K L+ V V HP M+++ + ++ VW++ET +T + V+ F
Sbjct: 8 KRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVA 67
Query: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
+ + + DM I+++++ E + H + +A+ P I+++S D IK+W+
Sbjct: 68 RKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWD 127
Query: 221 VQTGY-CVKTFTGHREWVRMVRPN-QDGTLIASCSNDQTVRVWVVATKECKAELREHEHV 278
+ C + F GH +V + N +D AS S D+T++VW + + L HE
Sbjct: 128 WDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
Query: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHD 338
V CI + SG P+L+SG+ D+ +K+WD C+ TL GH
Sbjct: 188 VNCIDYY------------------SGGDKPYLISGADDRLVKIWDYQNKTCVQTLEGHA 229
Query: 339 NWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLN 377
V FH I++ ++D T+R+W R TLN
Sbjct: 230 QNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLN 268
Score = 115 bits (289), Expect = 5e-26
Identities = 67/270 (24%), Positives = 126/270 (46%), Gaps = 22/270 (8%)
Query: 141 DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI 200
D +R L +D V+ + + + + + ++ +W+ + ++T D V +
Sbjct: 6 DIKRKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKF 65
Query: 201 MPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRV 260
+ + +V+ + D I+++ T V F H +++R + + I + S+D +++
Sbjct: 66 VARKNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKL 125
Query: 261 WVVATK-ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKT 319
W K C H H V I P+ + S S D+T
Sbjct: 126 WDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQ-------------------FASASLDRT 166
Query: 320 IKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGK--FILSCADDKTLRVWDYKNKRCMKTLN 377
IK+W + + TL GH+ V + ++SGG +++S ADD+ +++WDY+NK C++TL
Sbjct: 167 IKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWDYQNKTCVQTLE 226
Query: 378 AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
H V+ FH P ++TGS D TV++W
Sbjct: 227 GHAQNVSCASFHPELPIIITGSEDGTVRIW 256
Score = 92.4 bits (228), Expect = 7e-19
Identities = 58/223 (26%), Positives = 103/223 (46%), Gaps = 4/223 (1%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETG-DFERTLKGHTDSVQDISFD- 159
+ H + + HP ++++S+D IK+WD++ + +GHT V I +
Sbjct: 93 HMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINP 152
Query: 160 HSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD--HIVSASRDKTIK 217
AS S D TIK+W T+ GH+ V+ + GD +++S + D+ +K
Sbjct: 153 KDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVK 212
Query: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277
+W+ Q CV+T GH + V + + +I + S D TVR+W +T ++ L
Sbjct: 213 IWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIWHSSTYRLESTLNYGME 272
Query: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTI 320
V C++ S+ ++ GS K G+ P + + K I
Sbjct: 273 RVWCVASLRGSNNVALGYDEGSIIVKLGREEPAMSMDANGKII 315
Score = 70.9 bits (172), Expect = 2e-12
Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 24/227 (10%)
Query: 186 RTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQD 245
R + V SV + P ++++ + ++ +W +T VKTF VR +
Sbjct: 9 RKLTARSDRVKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVAR 68
Query: 246 GTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSG 305
+ + ++D +RV+ T E H + CI+ P
Sbjct: 69 KNWVVTGADDMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQ----------------- 111
Query: 306 KPGPFLLSGSRDKTIKMWDVSTGM-CLMTLVGHDNWVRGVLFH-SGGKFILSCADDKTLR 363
PF+L+ S D IK+WD C GH ++V ++ + S + D+T++
Sbjct: 112 ---PFILTSSDDMLIKLWDWDKKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIK 168
Query: 364 VWDYKNKRCMKTLNAHEHFVTSLDFHKTA--PYVVTGSVDQTVKVWE 408
VW + TL HE V +D++ PY+++G+ D+ VK+W+
Sbjct: 169 VWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKPYLISGADDRLVKIWD 215
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 117 bits (294), Expect = 1e-26
Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 68/325 (20%)
Query: 98 PPEKYA-LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK----- 147
PP K L GH S V ++PV ++ S S D+T ++W+ G + L+
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 148 -GH----TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
GH V + ++ G LLA S D ++W G T+ H + ++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNK 286
Query: 203 NGDHIVSASRDKTIKMWEVQTG-------------------------------------- 224
G++++SA DKT +W+ TG
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 225 ---YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
+ VKTF GH V ++ + G L+ASCS+D T+++W + C +L+ H +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341
I W+P TG T L S S D T+++WDV G+C TL+ H V
Sbjct: 407 IKWSP----------TGPATSNPNS-SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 342 RGVLFHSGGKFILSCADDKTLRVWD 366
V F GK++ S + DK + +W+
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 86.3 bits (212), Expect = 5e-17
Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 47/287 (16%)
Query: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192
L+GH V +++ LLAS S D T ++W+ CIR GHD
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 233
Query: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
+V+S+ +G + S D ++W + G T H+ + ++ N+ G +
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
S D+T +W T E K + H + W +++S S
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCST--------------- 337
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
D I + + + T GH N V + + G + SC+DD TL++W K
Sbjct: 338 ------DMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD 391
Query: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408
C+ L AH + ++ + T P + + S D TV++W+
Sbjct: 392 ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 80.5 bits (197), Expect = 3e-15
Identities = 41/136 (30%), Positives = 68/136 (50%), Gaps = 9/136 (6%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK-- 163
GH + V + + P ++ S S+D T+K+W + L+ H+ + I + +G
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 164 -------LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
+LAS S D T++LWD + C T+ H V SVA P+G ++ S S DK +
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 217 KMWEVQTGYCVKTFTG 232
+W Q+G V ++ G
Sbjct: 477 HIWNTQSGSLVHSYQG 492
Score = 34.3 bits (77), Expect = 0.21
Identities = 17/77 (22%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L H+ PV V F P + S S D + +W+ ++G + +G T + ++ ++
Sbjct: 446 HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNAR 504
Query: 162 GKLLASCSADMTIKLWD 178
G + + ++D ++ + D
Sbjct: 505 GDKVGASASDGSVCVLD 521
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 117 bits (294), Expect = 1e-26
Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 68/325 (20%)
Query: 98 PPEKYA-LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK----- 147
PP K L GH S V ++PV ++ S S D+T ++W+ G + L+
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 148 -GH----TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
GH V + ++ G LLA S D ++W G T+ H + ++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNK 286
Query: 203 NGDHIVSASRDKTIKMWEVQTG-------------------------------------- 224
G++++SA DKT +W+ TG
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 225 ---YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
+ VKTF GH V ++ + G L+ASCS+D T+++W + C +L+ H +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341
I W+P TG T L S S D T+++WDV G+C TL+ H V
Sbjct: 407 IKWSP----------TGPATSNPNS-SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 342 RGVLFHSGGKFILSCADDKTLRVWD 366
V F GK++ S + DK + +W+
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 86.3 bits (212), Expect = 5e-17
Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 47/287 (16%)
Query: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192
L+GH V +++ LLAS S D T ++W+ CIR GHD
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 233
Query: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
+V+S+ +G + S D ++W + G T H+ + ++ N+ G +
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
S D+T +W T E K + H + W +++S S
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCST--------------- 337
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
D I + + + T GH N V + + G + SC+DD TL++W K
Sbjct: 338 ------DMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD 391
Query: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408
C+ L AH + ++ + T P + + S D TV++W+
Sbjct: 392 ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 80.5 bits (197), Expect = 3e-15
Identities = 41/136 (30%), Positives = 68/136 (50%), Gaps = 9/136 (6%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK-- 163
GH + V + + P ++ S S+D T+K+W + L+ H+ + I + +G
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 164 -------LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
+LAS S D T++LWD + C T+ H V SVA P+G ++ S S DK +
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 217 KMWEVQTGYCVKTFTG 232
+W Q+G V ++ G
Sbjct: 477 HIWNTQSGSLVHSYQG 492
Score = 34.3 bits (77), Expect = 0.21
Identities = 17/77 (22%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L H+ PV V F P + S S D + +W+ ++G + +G T + ++ ++
Sbjct: 446 HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNAR 504
Query: 162 GKLLASCSADMTIKLWD 178
G + + ++D ++ + D
Sbjct: 505 GDKVGASASDGSVCVLD 521
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 117 bits (294), Expect = 1e-26
Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 68/325 (20%)
Query: 98 PPEKYA-LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYET----GDFERTLK----- 147
PP K L GH S V ++PV ++ S S D+T ++W+ G + L+
Sbjct: 168 PPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 227
Query: 148 -GH----TDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMP 202
GH V + ++ G LLA S D ++W G T+ H + ++
Sbjct: 228 GGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG-NLASTLGQHKGPIFALKWNK 286
Query: 203 NGDHIVSASRDKTIKMWEVQTG-------------------------------------- 224
G++++SA DKT +W+ TG
Sbjct: 287 KGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRL 346
Query: 225 ---YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
+ VKTF GH V ++ + G L+ASCS+D T+++W + C +L+ H +
Sbjct: 347 GCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWV 341
I W+P TG T L S S D T+++WDV G+C TL+ H V
Sbjct: 407 IKWSP----------TGPATSNPNS-SIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 342 RGVLFHSGGKFILSCADDKTLRVWD 366
V F GK++ S + DK + +W+
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWN 480
Score = 86.3 bits (212), Expect = 5e-17
Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 47/287 (16%)
Query: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFE-----------CIRTMHGHD-- 192
L+GH V +++ LLAS S D T ++W+ CIR GHD
Sbjct: 175 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE-GGHDVP 233
Query: 193 --HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIA 250
+V+S+ +G + S D ++W + G T H+ + ++ N+ G +
Sbjct: 234 SNKDVTSLDWNSDGTLLAMGSYDGFARIW-TENGNLASTLGQHKGPIFALKWNKKGNYVL 292
Query: 251 SCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPF 310
S D+T +W T E K + H + W +++S S
Sbjct: 293 SAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCST--------------- 337
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
D I + + + T GH N V + + G + SC+DD TL++W K
Sbjct: 338 ------DMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD 391
Query: 371 RCMKTLNAHEHFVTSLDFHKTAP---------YVVTGSVDQTVKVWE 408
C+ L AH + ++ + T P + + S D TV++W+
Sbjct: 392 ACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWD 438
Score = 80.5 bits (197), Expect = 3e-15
Identities = 41/136 (30%), Positives = 68/136 (50%), Gaps = 9/136 (6%)
Query: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK-- 163
GH + V + + P ++ S S+D T+K+W + L+ H+ + I + +G
Sbjct: 357 GHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPAT 416
Query: 164 -------LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
+LAS S D T++LWD + C T+ H V SVA P+G ++ S S DK +
Sbjct: 417 SNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYV 476
Query: 217 KMWEVQTGYCVKTFTG 232
+W Q+G V ++ G
Sbjct: 477 HIWNTQSGSLVHSYQG 492
Score = 34.3 bits (77), Expect = 0.21
Identities = 17/77 (22%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Query: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161
+ L H+ PV V F P + S S D + +W+ ++G + +G T + ++ ++
Sbjct: 446 HTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNAR 504
Query: 162 GKLLASCSADMTIKLWD 178
G + + ++D ++ + D
Sbjct: 505 GDKVGASASDGSVCVLD 521
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 117 bits (294), Expect = 1e-26
Identities = 87/324 (26%), Positives = 140/324 (43%), Gaps = 41/324 (12%)
Query: 105 SGHRSPVTRVIF-HPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
+G+ V V F P S +V AS +KV++ +T + L GHTD V + G
Sbjct: 331 AGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQ-ILHGHTDIVLALDVFRKGW 389
Query: 164 LLASCSADMTIKLWDFQG---FECIRTMHGHDHNVSSVAIMP-NGDHIVSASRDKTIKMW 219
L ASC+ D ++++W C+ GH H+V +V +V+ S+D T+K+W
Sbjct: 390 LFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Query: 220 EVQTGYCVK---------------TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVA 264
+ K T H + + V + L+A+ S D+T ++W +
Sbjct: 450 PLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP 509
Query: 265 TKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD 324
+ H + C+ ++P L + S D TIK+W
Sbjct: 510 QCQLLGVFSGHRRGLWCVQFSPMDQV--------------------LATASADGTIKLWA 549
Query: 325 VSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVT 384
+ CL T GHD V V F S G +LS D +++W KN C++TL+AHE V
Sbjct: 550 LQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVW 609
Query: 385 SLDFHKTAPYVVTGSVDQTVKVWE 408
L + + +TG+ D V +W+
Sbjct: 610 GLHCSRLDDHALTGASDSRVILWK 633
Score = 94.0 bits (232), Expect = 2e-19
Identities = 49/175 (28%), Positives = 85/175 (48%), Gaps = 2/175 (1%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
H + V P ++ + S+D T K+W GH + + F ++LA
Sbjct: 478 HDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLA 537
Query: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
+ SAD TIKLW Q F C++T GHD +V VA + G ++S+ D +K+W ++ C
Sbjct: 538 TASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNEC 597
Query: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW--VVATKECKAELREHEHVV 279
V+T H + V + ++ + ++D V +W V ++ + + R+ E VV
Sbjct: 598 VRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVV 652
Score = 89.4 bits (220), Expect = 6e-18
Identities = 76/344 (22%), Positives = 138/344 (40%), Gaps = 45/344 (13%)
Query: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISF--DHSGKL 164
H +PV + F P +++ + D ++VWD +G V ++F D + L
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
Query: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG 224
L S + D I++W Q C+ + H V+S+A +G ++S+ RDK +W++Q+
Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
Query: 225 YCVKTFTGH----------REWVRMVRPNQDGTLIASCSNDQTVRVWVVATKEC------ 268
+T E V + G + + T+RVW A+ +C
Sbjct: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQ 287
Query: 269 ---------------------KAELREHEHVVECISWAPESSYSSISEATGSETKKSGKP 307
A + + E S + ++ SE + + G
Sbjct: 288 PPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEV-LDVRFLGPE 346
Query: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
++ S +K++++ T C L GH + V + G SCA D+++R+W
Sbjct: 347 DSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRM 405
Query: 368 KNK---RCMKTLNAHEHFVTSLDFHK-TAPYVVTGSVDQTVKVW 407
C+ + H H V ++ + ++VTGS D TVK+W
Sbjct: 406 NKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Score = 79.7 bits (195), Expect = 4e-15
Identities = 79/378 (20%), Positives = 135/378 (35%), Gaps = 94/378 (24%)
Query: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGH----------TDSV 153
L+ H S VT + F M+S+ D +WD ++ RT+ + V
Sbjct: 191 LTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPV 250
Query: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRT-------------------------- 187
+ G + T+++W+ +C+ T
Sbjct: 251 SQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTA 310
Query: 188 -------------------MHGHDHNVSSVAIM-PNGDHIVSASRDKTIKMWEVQTGYCV 227
G+ V V + P H+V AS +K++E+QT C
Sbjct: 311 TADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSAC- 369
Query: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW---VVATKECKAELREHEHVVECISW 284
+ GH + V + + G L ASC+ DQ+VR+W C A+ H H
Sbjct: 370 QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTH------- 422
Query: 285 APESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV-----------STGMCLM- 332
S+ S K+S FL++GS+D T+K+W + G L+
Sbjct: 423 -------SVGTVCCSRLKES-----FLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQ 470
Query: 333 ---TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFH 389
T HD + V K + + + D+T ++W + + + H + + F
Sbjct: 471 AQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFS 530
Query: 390 KTAPYVVTGSVDQTVKVW 407
+ T S D T+K+W
Sbjct: 531 PMDQVLATASADGTIKLW 548
Score = 79.0 bits (193), Expect = 7e-15
Identities = 43/135 (31%), Positives = 68/135 (50%), Gaps = 1/135 (0%)
Query: 87 QKRDPKEW-IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT 145
Q R K W +P+ SGHR + V F P+ V+ +AS D TIK+W + +T
Sbjct: 499 QDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKT 558
Query: 146 LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGD 205
+GH SV ++F G L S +D +KLW + EC+RT+ H+ V + D
Sbjct: 559 FEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDD 618
Query: 206 HIVSASRDKTIKMWE 220
H ++ + D + +W+
Sbjct: 619 HALTGASDSRVILWK 633
Score = 47.4 bits (111), Expect = 2e-05
Identities = 28/100 (28%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFIL--SCADDKTLRVWDYK 368
L +G D +++WD+ G V V FH +L S A D +RVW +
Sbjct: 124 LATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSLQ 183
Query: 369 NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
++ C+ L AH VTSL F +++ D+ +W+
Sbjct: 184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,651,774
Number of Sequences: 37866
Number of extensions: 748377
Number of successful extensions: 7316
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 276
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 2490
Number of HSP's gapped (non-prelim): 2099
length of query: 410
length of database: 18,247,518
effective HSP length: 105
effective length of query: 305
effective length of database: 14,271,588
effective search space: 4352834340
effective search space used: 4352834340
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.