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Search of human proteins with 4557733
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557733 latent transforming growth factor beta binding
protein 2 [Homo sapiens]
(1821 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557733 latent transforming growth factor beta binding protei... 3975 0.0
gi|46249414 latent transforming growth factor beta binding prote... 1226 0.0
gi|110347437 latent transforming growth factor beta binding prot... 1133 0.0
gi|46249412 latent transforming growth factor beta binding prote... 1122 0.0
gi|110347412 latent transforming growth factor beta binding prot... 1110 0.0
gi|110347431 latent transforming growth factor beta binding prot... 1110 0.0
gi|194328809 latent transforming growth factor beta binding prot... 759 0.0
gi|18497288 latent transforming growth factor beta binding prote... 693 0.0
gi|24430141 fibrillin 1 precursor [Homo sapiens] 506 e-143
gi|66346695 fibrillin 2 precursor [Homo sapiens] 494 e-139
gi|56237021 fibrillin 3 precursor [Homo sapiens] 482 e-135
gi|134244285 Notch homolog 3 [Homo sapiens] 278 3e-74
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 277 6e-74
gi|148833508 notch1 preproprotein [Homo sapiens] 262 3e-69
gi|24041035 notch 2 preproprotein [Homo sapiens] 259 2e-68
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 255 2e-67
gi|55770876 notch4 preproprotein [Homo sapiens] 247 9e-65
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 226 2e-58
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 225 3e-58
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 225 3e-58
gi|34734066 fibulin 1 isoform D [Homo sapiens] 225 3e-58
gi|118572606 hemicentin 1 [Homo sapiens] 224 5e-58
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 218 6e-56
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 218 6e-56
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 197 1e-49
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 196 1e-49
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 191 4e-48
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 191 6e-48
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 189 2e-47
gi|4557679 jagged 1 precursor [Homo sapiens] 188 5e-47
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 3975 bits (10309), Expect = 0.0
Identities = 1821/1821 (100%), Positives = 1821/1821 (100%)
Query: 1 MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSY 60
MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSY
Sbjct: 1 MRPRTKARSPGRALRNPWRGFLPLTLALFVGAGHAQRDPVGRYEPAGGDANRLRRPGGSY 60
Query: 61 PAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQ 120
PAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQ
Sbjct: 61 PAAAAAKVYSLFREQDAPVAGLQPVERAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQ 120
Query: 121 TRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTA 180
TRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTA
Sbjct: 121 TRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTA 180
Query: 181 NSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWA 240
NSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWA
Sbjct: 181 NSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWA 240
Query: 241 ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRL 300
ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRL
Sbjct: 241 ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRL 300
Query: 301 HPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTIC 360
HPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTIC
Sbjct: 301 HPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTIC 360
Query: 361 KQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPA 420
KQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPA
Sbjct: 361 KQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPA 420
Query: 421 NSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHH 480
NSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHH
Sbjct: 421 NSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHH 480
Query: 481 PPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPL 540
PPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPL
Sbjct: 481 PPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPL 540
Query: 541 PPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPV 600
PPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPV
Sbjct: 541 PPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPV 600
Query: 601 IENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR 660
IENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR
Sbjct: 601 IENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR 660
Query: 661 CVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF 720
CVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF
Sbjct: 661 CVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF 720
Query: 721 REICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTW 780
REICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTW
Sbjct: 721 REICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTW 780
Query: 781 LEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTL 840
LEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTL
Sbjct: 781 LEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTL 840
Query: 841 STPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900
STPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG
Sbjct: 841 STPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900
Query: 901 RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY 960
RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY
Sbjct: 901 RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY 960
Query: 961 IMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVC 1020
IMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVC
Sbjct: 961 IMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVC 1020
Query: 1021 AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACEN 1080
AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACEN
Sbjct: 1021 AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACEN 1080
Query: 1081 GYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE 1140
GYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE
Sbjct: 1081 GYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECE 1140
Query: 1141 DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200
DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFF
Sbjct: 1141 DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFF 1200
Query: 1201 CLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260
CLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI
Sbjct: 1201 CLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260
Query: 1261 DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD 1320
DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD
Sbjct: 1261 DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD 1320
Query: 1321 NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYD 1380
NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYD
Sbjct: 1321 NTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYD 1380
Query: 1381 AQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440
AQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ
Sbjct: 1381 AQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440
Query: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG 1500
GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG
Sbjct: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG 1500
Query: 1501 RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLD 1560
RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLD
Sbjct: 1501 RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLD 1560
Query: 1561 LSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQ 1620
LSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQ
Sbjct: 1561 LSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQ 1620
Query: 1621 CALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYL 1680
CALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYL
Sbjct: 1621 CALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYL 1680
Query: 1681 GPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGIL 1740
GPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGIL
Sbjct: 1681 GPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGIL 1740
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY
Sbjct: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
Query: 1801 RCHCSPGYVAEAGPPHCTAKE 1821
RCHCSPGYVAEAGPPHCTAKE
Sbjct: 1801 RCHCSPGYVAEAGPPHCTAKE 1821
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 1226 bits (3173), Expect = 0.0
Identities = 703/1798 (39%), Positives = 936/1798 (52%), Gaps = 230/1798 (12%)
Query: 87 RAQPGWGSPRRPTEAEARRPSRAQQSRRVQPPAQ---TRRSTPLGQQQP--------APR 135
RA PG S R T ++ A Q R PP R + P GQ P AP
Sbjct: 74 RASPGVPSER--TRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPF 131
Query: 136 TRAAPALPRLGTPQRS----GAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVC 191
T+ + R PQ + G+ + +L G NVCGG+CC GW+ A + C KP C
Sbjct: 132 TKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSC 191
Query: 192 EPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAP---RRWAERSPNLRR 248
PPCQN G C RPQLCVC+ G +G CE + + P +P W +
Sbjct: 192 VPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKH 251
Query: 249 SSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASS 308
+S+ TL R P A + P G L Q SQ S++V +H T
Sbjct: 252 TSSKKADTLPRVSPVAQMTLTLKPKPSVG----LPQQIHSQVTPLSSQSVVIHHGQTQEY 307
Query: 309 QLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWG--LNLTEKIKKIKIVFTPTICKQTCAR 366
L P G+ T+ + PL + L+ +IK+VFTP+ICK TC +
Sbjct: 308 VLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTK 367
Query: 367 GHCANSCERGDTTTLYSQGGHGHDP--KSGFRIYFCQIPCLNGGRCIGRDECWCPANSTG 424
G C NSCE+G+TTTL S+ GH D + FR+ C +PC+NGG+C RD+C CP N TG
Sbjct: 368 GSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTG 427
Query: 425 KFCHLPIPQPDREPPGRGSR-PRALLEAPLKQSTFTLPL---SNQLASVN--PSLVKVHI 478
K C +P+ + S+ P L + ST TLPL S Q V P++V +H+
Sbjct: 428 KLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHV 487
Query: 479 HHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEP-- 536
HPPEASVQIHQV+++ G + E A PG S +P + +
Sbjct: 488 KHPPEASVQIHQVSRIDGPTGQKTKE------------AQPGQSQVSYQGLPVQKTQTIH 535
Query: 537 ---------PRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVT 587
P P AA + LGRC+ T+ QC L L+ QEDCCG+VG WG
Sbjct: 536 STYSHQQVIPHVYPVAA---KTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFN 592
Query: 588 LCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCT 647
C CP +P+ N +EC GYKR+N T CQDINEC G+C + EC+NT GSY CT
Sbjct: 593 KCQKCPKKPSYHGY-NQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCT 651
Query: 648 CRPGLMLDPSRSRCVSDK-AISMLQGLCYRSLGPGT-CTLPLAQRITKQICCCSRVGKAW 705
C+ G DP+ S CV D IS +G CYR + G C PL+ +TKQ+CCCS VGKAW
Sbjct: 652 CKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCS-VGKAW 710
Query: 706 GSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRK--AEEEELARPPREQG-QRSSG 762
G CEKCPLPGT AF+EICP G GYT + R + + +P Q +S+
Sbjct: 711 GPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTH 770
Query: 763 ALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGI 822
P PA+ +P+ +T S H P T P PE+ I
Sbjct: 771 PPPLPAKEEPVEALT---------------------FSREHGPGVAEPEVATAP-PEKEI 808
Query: 823 AEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQ 882
+ +E+ T PG + + G + + LHP
Sbjct: 809 PSLDQEK---------TKLEPGQPQLSPGISTI---------------------HLHPQF 838
Query: 883 AYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQ-----ECQDINECE-Q 936
+ P + +TS A+Q + +INEC
Sbjct: 839 PGIVIEKTSPPVPVEVAPEA-----------------STSSASQVIAPTQVTEINECTVN 881
Query: 937 PGVCSGGQCTNTEGSYHCECDQGY-IMVRKGHCQDINECRH-PGTCPDGRCVNSPGSYTC 994
P +C G C N Y C C +GY ++ C DI+EC C GRC N+ GS+ C
Sbjct: 882 PDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLC 941
Query: 995 LACEEGYRG--QSGSCVDVNECLTPGVCAHGKCTNLEGSFRCS-CEQGYEVTSDEKGCQD 1051
+ C G+ + +C+DV+ECL P VC G C N G+FRC C+ GY +T + C+D
Sbjct: 942 I-CPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGR-CED 999
Query: 1052 VDECASRASCPTGLCLNTEGSFACSACENGY--WVNEDGTACEDLDECAFPGVCPSGVCT 1109
+DEC + ++CP C+N+ GS+ C C G+ W + C D+DEC P VC +G C+
Sbjct: 1000 IDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ----CLDVDECLEPNVCANGDCS 1055
Query: 1110 NTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL- 1168
N GS+ C C GY +P C D+DEC+ + C+ G+CKNT GS++C C QG+QL
Sbjct: 1056 NLEGSYMCS-CHKGYTRTPDHKHCRDIDECQQG-NLCVNGQCKNTEGSFRCTCGQGYQLS 1113
Query: 1169 ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDP- 1227
A CED++EC CA HG+C N+ GSF C+C G+ ++ G C+D++EC
Sbjct: 1114 AAKDQCEDIDECQHRHLCA-HGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSV 1172
Query: 1228 CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTW-KCENSPGSYRCV 1286
C G C+NT GS++C C GFQ ++ C DI+ECE G +CG +C N+ GS+ CV
Sbjct: 1173 CQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPG--LCGPQGECLNTEGSFHCV 1229
Query: 1287 LGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345
CQ GF ++ +G C DIDEC N+T+C SHGFCDNT GSFRCLC QGF+ G CVD
Sbjct: 1230 --CQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD 1287
Query: 1346 VNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA 1405
VNECEL+ VCG A CENVEGSFLC+CA + +EY G CR R + ++
Sbjct: 1288 VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSR-----TSTDLDVDVDQ 1342
Query: 1406 PAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSEDSAEFSEIC 1463
P + +CY + C +VL N T+ ECCCT GA WGD C++ CP +AEF+E+C
Sbjct: 1343 PKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMC 1402
Query: 1464 PSGKGYIPV-EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDAS 1522
P GKG++P E + G Y DADEC++FG +C NG CLNT PGY C C G +YD
Sbjct: 1403 PKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPV 1462
Query: 1523 HKKCEDHDECQD-LACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDI 1581
+C D DECQD +C +G+CVNTEGS++CFC+ P+ LD S++RC+ S E + + D+
Sbjct: 1463 KLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDV 1522
Query: 1582 HMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVAR 1640
+ D+CW+ ++++ VCS PL G +TTYTECCC GEAW QCALCP + S+ YAQLCN+
Sbjct: 1523 YQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIP- 1581
Query: 1641 IEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSAD 1700
+ R+ YG D ++ E PE
Sbjct: 1582 VTGRRQP---------------------YGRDALVDFS----EQYTPE------------ 1604
Query: 1701 RTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCF 1760
P +Q ++ S FE LQAEECGILNGCENGRCVRV+EGYTCDCF
Sbjct: 1605 --------ADPYFIQDRFLNS-------FEELQAEECGILNGCENGRCVRVQEGYTCDCF 1649
Query: 1761 EGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
+G+ LD A M CVDVNECD+LN LC + C NT+GSY+C C PGYV P +CT
Sbjct: 1650 DGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCT 1707
Score = 250 bits (639), Expect = 8e-66
Identities = 194/642 (30%), Positives = 255/642 (39%), Gaps = 151/642 (23%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
ID C G N+C G C N +RC C GYQL ++ C D +EC G+C N
Sbjct: 1081 IDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN 1138
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
GS+ C C GY SG C+DINEC E VC G C NT GSY C C G+ +
Sbjct: 1139 TEGSFQCVCDQGYR--ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 1196
Query: 964 RKGHCQDINECRHPGTC-PDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTPGVC 1020
CQDINEC HPG C P G C+N+ GS+ C+ C++G+ +C D++EC+ VC
Sbjct: 1197 DNKTCQDINECEHPGLCGPQGECLNTEGSFHCV-CQQGFSISADGRTCEDIDECVNNTVC 1255
Query: 1021 -AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFACSAC 1078
+HG C N GSFRC C QG++ D +GC DV+EC + C C N EGSF C
Sbjct: 1256 DSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCA 1315
Query: 1079 ENGYWVNEDGTACE-----DLD-----------ECAF----PGVCPSGV----------C 1108
+ + C DLD EC + +C + + C
Sbjct: 1316 DENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCC 1375
Query: 1109 TNTAG------SFSC---------KDCDGGYRPSPLGDSC--------EDVDECE-DPQS 1144
T+ AG F C + C G P G+S +D DEC Q
Sbjct: 1376 TSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE 1435
Query: 1145 SCLGGECKNTVGSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCLC 1203
C G C NT Y+C C QG + C D++EC C G+C+N+ GS+ C C
Sbjct: 1436 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCID-GQCVNTEGSYNCFC 1494
Query: 1204 APGFVSAEGGTSC----------------QDV------DECATTDPCVGGHCVNTEGSFN 1241
V C QD+ DE + P VG TE
Sbjct: 1495 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTE---- 1550
Query: 1242 CLCETG--------FQPSPESGECVD------------------IDECEDY---GDPV-- 1270
C C G P +S + +D E Y DP
Sbjct: 1551 CCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI 1610
Query: 1271 ---------------------CGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECA 1308
C +C Y C C G+H+ C+D++EC
Sbjct: 1611 QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTC--DCFDGYHLDTAKMTCVDVNECD 1668
Query: 1309 ---NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVN 1347
N + C NTDGS++CLC G+ S C +N
Sbjct: 1669 ELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 130 bits (327), Expect = 1e-29
Identities = 185/770 (24%), Positives = 268/770 (34%), Gaps = 160/770 (20%)
Query: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCT-CRPGLMLDPSRSRCVS-DK 665
C GY+ C+DI+ECL C D +CVN+ GSY C C G +C+ D+
Sbjct: 985 CDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR--GWNGQCLDVDE 1042
Query: 666 AIS---MLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAW-GSECEKCPLPGTE-AF 720
+ G C G C+ T C + + G+ C TE +F
Sbjct: 1043 CLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSF 1102
Query: 721 REICPAGHGYTY-ASSDIRLSMRKAEEEELARPPR------------EQGQRSSGALPGP 767
R C G GY A+ D + + + L + +QG R+SG L
Sbjct: 1103 R--CTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG-LGDH 1159
Query: 768 AERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQE 827
E + LE ++ +GD + T+ ++ G Q I E +
Sbjct: 1160 CED------INECLEDKSVCQRGDC----INTAGSYDCTCPDGFQLDDNKTCQDINECEH 1209
Query: 828 EQVT-PSTDVLVT-------------LSTPG-----IDRCAAGATNVCGP-GTCVNLPDG 867
+ P + L T +S G ID C VC G C N
Sbjct: 1210 PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT--VCDSHGFCDNTAGS 1267
Query: 868 YRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRCINRVGSYSCFC------YPGYTL 919
+RC+C G+Q C D NEC L C G+ C N GS+ C C Y T
Sbjct: 1268 FRCLCYQGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVCADENQEYSPMTG 1326
Query: 920 ATSGATQECQDIN---------EC----EQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG 966
T D++ EC +C N C C G G
Sbjct: 1327 QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVT-KQECCCTSG---AGWG 1382
Query: 967 HCQDINECRHPGT------CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPG-- 1018
+I C GT CP G+ G + A E Y+ D +ECL G
Sbjct: 1383 DNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK-------DADECLLFGQE 1435
Query: 1019 VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSAC 1078
+C +G C N + C C+QG + C D+DEC +SC G C+NTEGS+ C C
Sbjct: 1436 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCF-C 1494
Query: 1079 ENGYWVNEDGTAC-------EDLDE-----------------CAFPGVCPSGVCTNT--- 1111
+ ++ C E ++E C+ P V T
Sbjct: 1495 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1554
Query: 1112 ---AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY---------- 1158
A C C PL DS + C P + ++ + +
Sbjct: 1555 YGEAWGMQCALC-------PLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADP 1607
Query: 1159 ---QCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTS 1215
Q F+ C +N C +G C+ + C C G+ +
Sbjct: 1608 YFIQDRFLNSFEELQAEECGILNGC-------ENGRCVRVQEGYTCDCFDGYHLDTAKMT 1660
Query: 1216 CQDVDECATTDP----CVGGHCVNTEGSFNCLCETGFQPSPESGECVDID 1261
C DV+EC + C C+NT+GS+ CLC G+ PS + C ++
Sbjct: 1661 CVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1710
Score = 36.2 bits (82), Expect = 0.30
Identities = 14/39 (35%), Positives = 19/39 (48%)
Query: 854 NVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECL 892
++C C+N Y+C+C PGY YCT N L
Sbjct: 1675 SLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1713
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 1133 bits (2931), Expect = 0.0
Identities = 638/1607 (39%), Positives = 808/1607 (50%), Gaps = 224/1607 (13%)
Query: 349 KKIKIVFTPTICKQTCARG----HCANSCERGDTTTLYSQGGHGHDPKS-GFRIYFCQIP 403
+++++ FTP +C C G C +C + T++ S G P GFR + C +
Sbjct: 30 ERLRVRFTPVVCGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLCPLI 89
Query: 404 CLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLS 463
C NGG C+ D C CP + GKFC L G+RP A L +S +T+PL+
Sbjct: 90 CHNGGVCVKPDRCLCPPDFAGKFCQLH---------SSGARPPAPAVPGLTRSVYTMPLA 140
Query: 464 NQLASVN--PSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGH 521
N + S+V VH+ HP EASV +HQV +V G EEA E
Sbjct: 141 NHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAA-------- 192
Query: 522 SLWDSNNIPARSGEPPRPLPPAAPRPRGL-----LGRCYLNTVNGQCANPLLELTTQEDC 576
A + P L +APR G G C+ G+CA+PL L TQE C
Sbjct: 193 --------RAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVC 244
Query: 577 CGSVGAFWGVTLCAPCPPRPA-SPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDA 635
C G WGV C C R S + CP G++R+N + C+D++EC T G C+
Sbjct: 245 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGS-CEDVDECATGGRCQHG 303
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQI 695
EC NTRG Y C C G +LD SRS C+S IS +G C+R L G C+LP+ + ITKQI
Sbjct: 304 ECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQI 363
Query: 696 CCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPRE 755
CCCSRVGKAWG C+ CP G+E FREICPAG GY Y++SD+R + R +E PPR
Sbjct: 364 CCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQE----PPRV 419
Query: 756 QGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTP 815
+ PA +P T + D + G + PAW T P
Sbjct: 420 SLSQPRTL---PATSRPSAGFLPTHRLEPRPEPRPDPRPGP-ELPLPSIPAW-----TGP 470
Query: 816 PMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPG 875
+PE G P C VCGPG C++ P GY C C G
Sbjct: 471 EIPESG---------------------PSSGMCQRNP-QVCGPGRCISRPSGYTCACDSG 508
Query: 876 YQLHPSQAYCTDDNECLR--DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINE 933
++L P C D +EC R PC GRC N GS+ C C PG+ A EC D++E
Sbjct: 509 FRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAA--ECLDVDE 565
Query: 934 CEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINEC-RHPGTCPDGRCVNSPG 990
C + P C G+C NT GS+ C C GY G CQD++EC + PG C G C N PG
Sbjct: 566 CHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPG 625
Query: 991 SYTCLACEEGYRGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049
S+ C+ C G+RG S DV+EC P C G+C N GSF C+C G+ C
Sbjct: 626 SFRCV-CPAGFRG-SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPC 683
Query: 1050 QDVDECA-SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVC 1108
QDVDECA S C G C NTEGSF C C G+ N G+ CED+DEC CP C
Sbjct: 684 QDVDECARSPPPCTYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECENHLACPGQEC 742
Query: 1109 TNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQ 1167
N+ GSF C+ C G+ C DVDEC C G C NT GS++C C G++
Sbjct: 743 VNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800
Query: 1168 LANGTV--CEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT 1225
+G C DVNEC+ + C PHGECLN+ GSF C CAPG+ G SC DVDEC+
Sbjct: 801 APSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECSEE 860
Query: 1226 DPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRC 1285
D C G C NT+GSF C+C G + P+ C+D+DEC + G +CG+ +CENSPGSYRC
Sbjct: 861 DLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRC 920
Query: 1286 VLGCQPGFHMAPNGDCIDIDECA------------------------------------- 1308
V C PG+H P G C D+DEC
Sbjct: 921 VRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGC 980
Query: 1309 -------NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALC 1361
N + CG+H C N GSF+CLCDQG+E + G CVDVNECE + VCGAALC
Sbjct: 981 QDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALC 1040
Query: 1362 ENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQ---SMSEAPTGDHAPA---------- 1407
ENVEGSFLC+C + EE+D G C PR + G S +AP PA
Sbjct: 1041 ENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPLPRR 1100
Query: 1408 ----------PTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSED 1455
R +CY C ++L RN T ECCCT G WG C + CP +
Sbjct: 1101 PSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQCPGTE 1160
Query: 1456 SAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNP 1515
+AE+ +CP G+GY+ G ++ D DEC +F +C +G C+NT PGY C C+
Sbjct: 1161 TAEYQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSN 1216
Query: 1516 GFHYDASHKKCEDHDECQD--LACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSST 1573
G++Y +C D+DEC D ACE G CVNT GS+HC C PPL LD SQ+RC+++ S +
Sbjct: 1217 GYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNESQS 1276
Query: 1574 EDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVY 1632
D ++ +CW++V D VCS P + TYTECCC GEAW CALCP + S+ +
Sbjct: 1277 -----LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQDSDDF 1331
Query: 1633 AQLCNVARIEAEREAGVHFRPG-----YEYGPG----------------PDDLHYSIYGP 1671
LCNV R A RPG YEYGP P L Y Y P
Sbjct: 1332 EALCNVLRPPAYSPP----RPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYDPYPP 1387
Query: 1672 DGAPFYNYLGP-------------------EDTVPEPAFPNTAG--HSADRTPILESPLQ 1710
PF P E P P P T S D P +
Sbjct: 1388 PPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFPEPEE 1447
Query: 1711 PSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHM 1770
P E Y S EP +E L+AEECGIL+GC NGRCVRV EG+TC CF+G++LD M
Sbjct: 1448 PPE-GGSYAGSLAEP---YEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRM 1503
Query: 1771 ACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
ACVD+NECD+ + LCV+ C NT+GS+RC C PG+ P HC
Sbjct: 1504 ACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1550
Score = 306 bits (783), Expect = 2e-82
Identities = 258/825 (31%), Positives = 341/825 (41%), Gaps = 140/825 (16%)
Query: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
P VC G C + ++C CD G+R SP G C DVDEC C G C+N+ GS++
Sbjct: 486 PQVCGPGRCISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 544
Query: 1160 CLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
C+C GF+ C DV+EC G C N+ GSF C+C G+ +A G SCQD
Sbjct: 545 CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 604
Query: 1219 VDECATTDP--CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKC 1276
VDEC T P C G C N GSF C+C GF+ S D+DEC P CG +C
Sbjct: 605 VDEC-TQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE---DVDECAQEPPP-CGPGRC 659
Query: 1277 ENSPGSYRCVLGCQPGFHM-APNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
+N+ GS+ C C GF P C D+DECA ++G C+NT+GSF+C+C GF+
Sbjct: 660 DNTAGSFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQ 717
Query: 1336 ISPSGWDCVDVNECELMLAVCGAALCENVEGSFLC-LCAS----------DLEEYDAQEG 1384
+ +G +C DV+ECE LA C C N GSF C C S D++E +
Sbjct: 718 PNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP 776
Query: 1385 HCRPRG-----AGGQSMS-----EAPTGDHAPAPTRMDCYSGQK--GHAPCSSVLGRNTT 1432
C P G G S AP+G P +C G H C + G
Sbjct: 777 PCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDG---- 832
Query: 1433 QAECCCTQGASWG---------DAC---DLCPS----EDSAEFSEICPSGKGYIPVEGAW 1476
C C G G D C DLC S F ICP G P
Sbjct: 833 SFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP----- 887
Query: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCL--CNPGFHYDASHKKCEDHDECQD 1534
D DEC GP LC + RC N+ Y C+ C+PG+H C+D DECQ+
Sbjct: 888 --DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQE 944
Query: 1535 LA---CENGECVNTEGSFHCF--CSPPLT---------LDLSQQR--------CMNSTSS 1572
C C NT GS+ C C P +D + R C N S
Sbjct: 945 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS 1004
Query: 1573 TEDLPD----------HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-EAWSQQC 1621
+ L D H + ++ C + VC L + C C + E +
Sbjct: 1005 FQCLCDQGYEGARDGRHCVDVNEC--ETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMT 1062
Query: 1622 ALC-PPRSSEVYAQLCNVARIEAEREAGVHFRPGYE-------------YGPGPDDLHYS 1667
C PPR+S A ++ +A + RP G G + ++
Sbjct: 1063 GRCVPPRTS---AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1119
Query: 1668 IYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA----DRTPILESPLQPSELQPH---YVA 1720
PD N L T E G + + P E+ S L PH Y+A
Sbjct: 1120 TAAPDACD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQS-LCPHGRGYLA 1176
Query: 1721 SHPEPPAGFEGLQ--AEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVN 1776
P+G L+ +EC + C++G CV GY+C C G+ + C+D +
Sbjct: 1177 -----PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1231
Query: 1777 ECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
EC D PA C G C NT GSY C C P V + C + E
Sbjct: 1232 ECAD-EEPA--CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNE 1273
Score = 43.1 bits (100), Expect = 0.002
Identities = 48/186 (25%), Positives = 58/186 (31%), Gaps = 72/186 (38%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP--------------PCQNRGSCSRPQLC--- 207
G +CG Q C ++ P C+P C+NR C +C
Sbjct: 946 GPEICGAQRCEN----TPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1001
Query: 208 ------VCRSGFRGAR----------------------CEEV-------IPD--EEFDPQ 230
+C G+ GAR CE V P+ EEFDP
Sbjct: 1002 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1061
Query: 231 NSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQ 290
R P R GT +QP AP SP P PP L T P Q
Sbjct: 1062 TGRCVPPR-------------TSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST-PRQG 1107
Query: 291 HVGLSR 296
VG R
Sbjct: 1108 PVGSGR 1113
Score = 41.2 bits (95), Expect = 0.009
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
C GF+ + +C DV+EC C HG C NT G Y C C G++ ++ C
Sbjct: 277 CPTGFE--RVNGSCEDVDEC----ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 330
Query: 1819 AK 1820
++
Sbjct: 331 SQ 332
Score = 36.2 bits (82), Expect = 0.30
Identities = 36/136 (26%), Positives = 48/136 (35%), Gaps = 24/136 (17%)
Query: 111 QSRRVQPPAQTRRSTPLGQQQPA-------PRTRAAPALPRLGTPQRSGAAPPTPPRGRL 163
+ RRV PP R + P P RA P PP GR
Sbjct: 523 ECRRVPPPCAPGRC----ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 578
Query: 164 T---GRNVC----GGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGF 213
G +C G Q P + + C + P RG+C CVC +GF
Sbjct: 579 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGACKNLPGSFRCVCPAGF 635
Query: 214 RGARCEEVIPDEEFDP 229
RG+ CEE + + +P
Sbjct: 636 RGSACEEDVDECAQEP 651
Score = 32.3 bits (72), Expect = 4.3
Identities = 27/104 (25%), Positives = 36/104 (34%), Gaps = 9/104 (8%)
Query: 119 AQTRRSTPLGQQQPAPRTRAAPALPRLGT---PQRSGAAPPTPPRGRLTGRNVCGGQCCP 175
AQ LG+ R R P + L P S P PR + + G P
Sbjct: 17 AQLGPQPGLGRLGERLRVRFTPVVCGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAP 76
Query: 176 GWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCE 219
G + +C C N G C +P C+C F G C+
Sbjct: 77 GGPGFRAF------LCPLICHNGGVCVKPDRCLCPPDFAGKFCQ 114
>gi|46249412 latent transforming growth factor beta binding protein 1
isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 1122 bits (2902), Expect = 0.0
Identities = 619/1515 (40%), Positives = 823/1515 (54%), Gaps = 204/1515 (13%)
Query: 350 KIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDP--KSGFRIYFCQIPCLNG 407
+IK+VFTP+ICK TC +G C NSCE+G+TTTL S+ GH D + FR+ C +PC+NG
Sbjct: 25 RIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNG 84
Query: 408 GRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSR-PRALLEAPLKQSTFTLPL---S 463
G+C RD+C CP N TGK C +P+ + S+ P L + ST TLPL S
Sbjct: 85 GQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTS 144
Query: 464 NQLASVN--PSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGH 521
Q V P++V +H+ HPPEASVQIHQV+++ G + E A PG
Sbjct: 145 QQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKE------------AQPGQ 192
Query: 522 SLWDSNNIPARSGEP-----------PRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLEL 570
S +P + + P P AA + LGRC+ T+ QC L L
Sbjct: 193 SQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAA---KTQLGRCFQETIGSQCGKALPGL 249
Query: 571 TTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLG 630
+ QEDCCG+VG WG C CP +P+ N +EC GYKR+N T CQDINEC G
Sbjct: 250 SKQEDCCGTVGTSWGFNKCQKCPKKPSYHGY-NQMMECLPGYKRVNNTFCQDINECQLQG 308
Query: 631 LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK-AISMLQGLCYRSLGPGT-CTLPLA 688
+C + EC+NT GSY CTC+ G DP+ S CV D IS +G CYR + G C PL+
Sbjct: 309 VCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLS 368
Query: 689 QRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRK--AEE 746
+TKQ+CCCS VGKAWG CEKCPLPGT AF+EICP G GYT + R + +
Sbjct: 369 VHLTKQLCCCS-VGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKG 427
Query: 747 EELARPPREQG-QRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAP 805
+P Q +S+ P PA+ +P+ +T S H P
Sbjct: 428 PVFVKPKNTQPVAKSTHPPPLPAKEEPVEALT---------------------FSREHGP 466
Query: 806 AWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLP 865
T P PE+ I + +E+ T PG + + G + +
Sbjct: 467 GVAEPEVATAP-PEKEIPSLDQEK---------TKLEPGQPQLSPGISTI---------- 506
Query: 866 DGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGAT 925
LHP + P + +TS A+
Sbjct: 507 -----------HLHPQFPGIVIEKTSPPVPVEVAPEA-----------------STSSAS 538
Query: 926 Q-----ECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGY-IMVRKGHCQDINECRH-P 977
Q + +INEC P +C G C N Y C C +GY ++ C DI+EC
Sbjct: 539 QVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQ 598
Query: 978 GTCPDGRCVNSPGSYTCLACEEGYRG--QSGSCVDVNECLTPGVCAHGKCTNLEGSFRCS 1035
C GRC N+ GS+ C+ C G+ + +C+DV+ECL P VC G C N G+FRC
Sbjct: 599 HLCSQGRCENTEGSFLCI-CPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCE 657
Query: 1036 -CEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGY--WVNEDGTACE 1092
C+ GY +T + C+D+DEC + ++CP C+N+ GS+ C C G+ W + C
Sbjct: 658 YCDSGYRMTQRGR-CEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ----CL 712
Query: 1093 DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECK 1152
D+DEC P VC +G C+N GS+ C C GY +P C D+DEC+ + C+ G+CK
Sbjct: 713 DVDECLEPNVCANGDCSNLEGSYMCS-CHKGYTRTPDHKHCRDIDECQQG-NLCVNGQCK 770
Query: 1153 NTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAE 1211
NT GS++C C QG+QL A CED++EC CA HG+C N+ GSF C+C G+ ++
Sbjct: 771 NTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA-HGQCRNTEGSFQCVCDQGYRASG 829
Query: 1212 GGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPV 1270
G C+D++EC C G C+NT GS++C C GFQ ++ C DI+ECE G +
Sbjct: 830 LGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD-DNKTCQDINECEHPG--L 886
Query: 1271 CGTW-KCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRC 1328
CG +C N+ GS+ CV CQ GF ++ +G C DIDEC N+T+C SHGFCDNT GSFRC
Sbjct: 887 CGPQGECLNTEGSFHCV--CQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRC 944
Query: 1329 LCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRP 1388
LC QGF+ G CVDVNECEL+ VCG A CENVEGSFLC+CA + +EY G CR
Sbjct: 945 LCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004
Query: 1389 RGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDAC 1448
R + ++ P + +CY + C +VL N T+ ECCCT GA WGD C
Sbjct: 1005 R-----TSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNC 1059
Query: 1449 DL--CPSEDSAEFSEICPSGKGYIPV-EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNT 1505
++ CP +AEF+E+CP GKG++P E + G Y DADEC++FG +C NG CLNT
Sbjct: 1060 EIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNT 1119
Query: 1506 VPGYVCLCNPGFHYDASHKKCEDHDECQD-LACENGECVNTEGSFHCFCSPPLTLDLSQQ 1564
PGY C C G +YD +C D DECQD +C +G+CVNTEGS++CFC+ P+ LD S++
Sbjct: 1120 RPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEK 1179
Query: 1565 RCMNSTSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCAL 1623
RC+ S E + + D++ D+CW+ ++++ VCS PL G +TTYTECCC GEAW QCAL
Sbjct: 1180 RCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCAL 1239
Query: 1624 CPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPE 1683
CP + S+ YAQLCN+ + R+ YG D ++ E
Sbjct: 1240 CPLKDSDDYAQLCNIP-VTGRRQP---------------------YGRDALVDFS----E 1273
Query: 1684 DTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGC 1743
PE P +Q ++ S FE LQAEECGILNGC
Sbjct: 1274 QYTPE--------------------ADPYFIQDRFLNS-------FEELQAEECGILNGC 1306
Query: 1744 ENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH 1803
ENGRCVRV+EGYTCDCF+G+ LD A M CVDVNECD+LN LC + C NT+GSY+C
Sbjct: 1307 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366
Query: 1804 CSPGYVAEAGPPHCT 1818
C PGYV P +CT
Sbjct: 1367 CLPGYVPSDKPNYCT 1381
Score = 250 bits (639), Expect = 8e-66
Identities = 194/642 (30%), Positives = 255/642 (39%), Gaps = 151/642 (23%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
ID C G N+C G C N +RC C GYQL ++ C D +EC G+C N
Sbjct: 755 IDECQQG--NLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRN 812
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
GS+ C C GY SG C+DINEC E VC G C NT GSY C C G+ +
Sbjct: 813 TEGSFQCVCDQGYR--ASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLD 870
Query: 964 RKGHCQDINECRHPGTC-PDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTPGVC 1020
CQDINEC HPG C P G C+N+ GS+ C+ C++G+ +C D++EC+ VC
Sbjct: 871 DNKTCQDINECEHPGLCGPQGECLNTEGSFHCV-CQQGFSISADGRTCEDIDECVNNTVC 929
Query: 1021 -AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFACSAC 1078
+HG C N GSFRC C QG++ D +GC DV+EC + C C N EGSF C
Sbjct: 930 DSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCA 989
Query: 1079 ENGYWVNEDGTACE-----DLD-----------ECAF----PGVCPSGV----------C 1108
+ + C DLD EC + +C + + C
Sbjct: 990 DENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCC 1049
Query: 1109 TNTAG------SFSC---------KDCDGGYRPSPLGDSC--------EDVDECE-DPQS 1144
T+ AG F C + C G P G+S +D DEC Q
Sbjct: 1050 TSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQE 1109
Query: 1145 SCLGGECKNTVGSYQCLCPQGFQLANGTV-CEDVNECMGEEHCAPHGECLNSHGSFFCLC 1203
C G C NT Y+C C QG + C D++EC C G+C+N+ GS+ C C
Sbjct: 1110 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCID-GQCVNTEGSYNCFC 1168
Query: 1204 APGFVSAEGGTSC----------------QDV------DECATTDPCVGGHCVNTEGSFN 1241
V C QD+ DE + P VG TE
Sbjct: 1169 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTE---- 1224
Query: 1242 CLCETG--------FQPSPESGECVD------------------IDECEDY---GDPV-- 1270
C C G P +S + +D E Y DP
Sbjct: 1225 CCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFI 1284
Query: 1271 ---------------------CGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECA 1308
C +C Y C C G+H+ C+D++EC
Sbjct: 1285 QDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTC--DCFDGYHLDTAKMTCVDVNECD 1342
Query: 1309 ---NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVN 1347
N + C NTDGS++CLC G+ S C +N
Sbjct: 1343 ELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 130 bits (327), Expect = 1e-29
Identities = 185/770 (24%), Positives = 268/770 (34%), Gaps = 160/770 (20%)
Query: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCT-CRPGLMLDPSRSRCVS-DK 665
C GY+ C+DI+ECL C D +CVN+ GSY C C G +C+ D+
Sbjct: 659 CDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFR--GWNGQCLDVDE 716
Query: 666 AIS---MLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAW-GSECEKCPLPGTE-AF 720
+ G C G C+ T C + + G+ C TE +F
Sbjct: 717 CLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSF 776
Query: 721 REICPAGHGYTY-ASSDIRLSMRKAEEEELARPPR------------EQGQRSSGALPGP 767
R C G GY A+ D + + + L + +QG R+SG L
Sbjct: 777 R--CTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASG-LGDH 833
Query: 768 AERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQE 827
E + LE ++ +GD + T+ ++ G Q I E +
Sbjct: 834 CED------INECLEDKSVCQRGDC----INTAGSYDCTCPDGFQLDDNKTCQDINECEH 883
Query: 828 EQVT-PSTDVLVT-------------LSTPG-----IDRCAAGATNVCGP-GTCVNLPDG 867
+ P + L T +S G ID C VC G C N
Sbjct: 884 PGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNT--VCDSHGFCDNTAGS 941
Query: 868 YRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRCINRVGSYSCFC------YPGYTL 919
+RC+C G+Q C D NEC L C G+ C N GS+ C C Y T
Sbjct: 942 FRCLCYQGFQAPQDGQGCVDVNECELLSGVC-GEAFCENVEGSFLCVCADENQEYSPMTG 1000
Query: 920 ATSGATQECQDIN---------EC----EQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG 966
T D++ EC +C N C C G G
Sbjct: 1001 QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVT-KQECCCTSG---AGWG 1056
Query: 967 HCQDINECRHPGT------CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPG-- 1018
+I C GT CP G+ G + A E Y+ D +ECL G
Sbjct: 1057 DNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYK-------DADECLLFGQE 1109
Query: 1019 VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSAC 1078
+C +G C N + C C+QG + C D+DEC +SC G C+NTEGS+ C C
Sbjct: 1110 ICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCF-C 1168
Query: 1079 ENGYWVNEDGTAC-------EDLDE-----------------CAFPGVCPSGVCTNT--- 1111
+ ++ C E ++E C+ P V T
Sbjct: 1169 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1228
Query: 1112 ---AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY---------- 1158
A C C PL DS + C P + ++ + +
Sbjct: 1229 YGEAWGMQCALC-------PLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADP 1281
Query: 1159 ---QCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTS 1215
Q F+ C +N C +G C+ + C C G+ +
Sbjct: 1282 YFIQDRFLNSFEELQAEECGILNGC-------ENGRCVRVQEGYTCDCFDGYHLDTAKMT 1334
Query: 1216 CQDVDECATTDP----CVGGHCVNTEGSFNCLCETGFQPSPESGECVDID 1261
C DV+EC + C C+NT+GS+ CLC G+ PS + C ++
Sbjct: 1335 CVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLN 1384
Score = 36.2 bits (82), Expect = 0.30
Identities = 14/39 (35%), Positives = 19/39 (48%)
Query: 854 NVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECL 892
++C C+N Y+C+C PGY YCT N L
Sbjct: 1349 SLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTAL 1387
Score = 33.9 bits (76), Expect = 1.5
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 179 TANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCE 219
T +TN + +C PC N G CS C C F G C+
Sbjct: 66 TLTATNFRVV-ICHLPCMNGGQCSSRDKCQCPPNFTGKLCQ 105
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 1110 bits (2870), Expect = 0.0
Identities = 623/1551 (40%), Positives = 782/1551 (50%), Gaps = 219/1551 (14%)
Query: 400 CQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFT 459
C + C NGG C+ D C CP + GKFC L G+RP A L +S +T
Sbjct: 116 CPLICHNGGVCVKPDRCLCPPDFAGKFCQLH---------SSGARPPAPAVPGLTRSVYT 166
Query: 460 LPLSNQLASVN--PSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPA 517
+PL+N + S+V VH+ HP EASV +HQV +V G EEA E
Sbjct: 167 MPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAA---- 222
Query: 518 SPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGL-----LGRCYLNTVNGQCANPLLELTT 572
A + P L +APR G G C+ G+CA+PL L T
Sbjct: 223 ------------RAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRT 270
Query: 573 QEDCCGSVGAFWGVTLCAPCPPRPA-SPVIENGQLECPQGYKRLNLTHCQDINECLTLGL 631
QE CC G WGV C C R S + CP G++R+N + C+D++EC T G
Sbjct: 271 QEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGS-CEDVDECATGGR 329
Query: 632 CKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRI 691
C+ EC NTRG Y C C G +LD SRS C+S IS +G C+R L G C+LP+ + I
Sbjct: 330 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNI 389
Query: 692 TKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELAR 751
TKQICCCSRVGKAWG C+ CP G+E FREICPAG GY Y++SD+R + R +E
Sbjct: 390 TKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQE---- 445
Query: 752 PPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGN 811
PPR + PA +P T + D + G + PAW
Sbjct: 446 PPRVSLSQPRTL---PATSRPSAGFLPTHRLEPRPEPRPDPRPGP-ELPLPSIPAW---- 497
Query: 812 ATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCV 871
T P +PE G P C VCGPG C++ P GY C
Sbjct: 498 -TGPEIPESG---------------------PSSGMCQRNP-QVCGPGRCISRPSGYTCA 534
Query: 872 CSPGYQLHPSQAYCTDDNECLR--DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQ 929
C G++L P C D +EC R PC GRC N GS+ C C PG+ A EC
Sbjct: 535 CDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAA--ECL 591
Query: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINEC-RHPGTCPDGRCV 986
D++EC + P C G+C NT GS+ C C GY G CQD++EC + PG C G C
Sbjct: 592 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACK 651
Query: 987 NSPGSYTCLACEEGYRGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSD 1045
N PGS+ C+ C G+RG S DV+EC P C G+C N GSF C+C G+
Sbjct: 652 NLPGSFRCV-CPAGFRG-SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 709
Query: 1046 EKGCQDVDECA-SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCP 1104
CQDVDECA S C G C NTEGSF C C G+ N G+ CED+DEC CP
Sbjct: 710 GAPCQDVDECARSPPPCTYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECENHLACP 768
Query: 1105 SGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCP 1163
C N+ GSF C+ C G+ C DVDEC C G C NT GS++C C
Sbjct: 769 GQECVNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCA 826
Query: 1164 QGFQLANGTV--CEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221
G++ +G C DVNEC+ + C PHGECLN+ GSF C CAPG+ G SC DVDE
Sbjct: 827 PGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE 886
Query: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG 1281
C+ D C G C NT+GSF C+C G + P+ C+D+DEC + G +CG+ +CENSPG
Sbjct: 887 CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 946
Query: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECA--------------------------------- 1308
SYRCV C PG+H P G C D+DEC
Sbjct: 947 SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTP 1006
Query: 1309 -----------NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCG 1357
N + CG+H C N GSF+CLCDQG+E + G CVDVNECE + VCG
Sbjct: 1007 GGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCG 1066
Query: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQ---SMSEAPTGDHAPA------ 1407
AALCENVEGSFLC+C + EE+D G C PR + G S +AP PA
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1126
Query: 1408 --------------PTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--C 1451
R +CY C ++L RN T ECCCT G WG C + C
Sbjct: 1127 LPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQC 1186
Query: 1452 PSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVC 1511
P ++AE+ +CP G+GY+ G ++ D DEC +F +C +G C+NT PGY C
Sbjct: 1187 PGTETAEYQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSC 1242
Query: 1512 LCNPGFHYDASHKKCEDHDECQD--LACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNS 1569
C+ G++Y +C D+DEC D ACE G CVNT GS+HC C PPL LD SQ+RC+++
Sbjct: 1243 YCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSN 1302
Query: 1570 TSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRS 1628
S + D ++ +CW++V D VCS P + TYTECCC GEAW CALCP +
Sbjct: 1303 ESQS-----LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQD 1357
Query: 1629 SEVYAQLCNVARIEAEREAGVHFRPG-----YEYGPG----------------PDDLHYS 1667
S+ + LCNV R A RPG YEYGP P L Y
Sbjct: 1358 SDDFEALCNVLRPPAYSPP----RPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYD 1413
Query: 1668 IYGPDGAPFYNYLGP-------------------EDTVPEPAFPNTAG--HSADRTPILE 1706
Y P PF P E P P P T S D
Sbjct: 1414 PYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFP 1473
Query: 1707 SPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLD 1766
P +P E Y S EP +E L+AEECGIL+GC NGRCVRV EG+TC CF+G++LD
Sbjct: 1474 EPEEPPE-GGSYAGSLAEP---YEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLD 1529
Query: 1767 AAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
MACVD+NECD+ + LCV+ C NT+GS+RC C PG+ P HC
Sbjct: 1530 MTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1580
Score = 306 bits (783), Expect = 2e-82
Identities = 258/825 (31%), Positives = 341/825 (41%), Gaps = 140/825 (16%)
Query: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
P VC G C + ++C CD G+R SP G C DVDEC C G C+N+ GS++
Sbjct: 516 PQVCGPGRCISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 574
Query: 1160 CLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
C+C GF+ C DV+EC G C N+ GSF C+C G+ +A G SCQD
Sbjct: 575 CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 634
Query: 1219 VDECATTDP--CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKC 1276
VDEC T P C G C N GSF C+C GF+ S D+DEC P CG +C
Sbjct: 635 VDEC-TQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE---DVDECAQEPPP-CGPGRC 689
Query: 1277 ENSPGSYRCVLGCQPGFHM-APNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
+N+ GS+ C C GF P C D+DECA ++G C+NT+GSF+C+C GF+
Sbjct: 690 DNTAGSFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQ 747
Query: 1336 ISPSGWDCVDVNECELMLAVCGAALCENVEGSFLC-LCAS----------DLEEYDAQEG 1384
+ +G +C DV+ECE LA C C N GSF C C S D++E +
Sbjct: 748 PNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP 806
Query: 1385 HCRPRG-----AGGQSMS-----EAPTGDHAPAPTRMDCYSGQK--GHAPCSSVLGRNTT 1432
C P G G S AP+G P +C G H C + G
Sbjct: 807 PCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDG---- 862
Query: 1433 QAECCCTQGASWG---------DAC---DLCPS----EDSAEFSEICPSGKGYIPVEGAW 1476
C C G G D C DLC S F ICP G P
Sbjct: 863 SFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP----- 917
Query: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCL--CNPGFHYDASHKKCEDHDECQD 1534
D DEC GP LC + RC N+ Y C+ C+PG+H C+D DECQ+
Sbjct: 918 --DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQE 974
Query: 1535 LA---CENGECVNTEGSFHCF--CSPPLT---------LDLSQQR--------CMNSTSS 1572
C C NT GS+ C C P +D + R C N S
Sbjct: 975 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS 1034
Query: 1573 TEDLPD----------HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-EAWSQQC 1621
+ L D H + ++ C + VC L + C C + E +
Sbjct: 1035 FQCLCDQGYEGARDGRHCVDVNEC--ETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMT 1092
Query: 1622 ALC-PPRSSEVYAQLCNVARIEAEREAGVHFRPGYE-------------YGPGPDDLHYS 1667
C PPR+S A ++ +A + RP G G + ++
Sbjct: 1093 GRCVPPRTS---AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1149
Query: 1668 IYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA----DRTPILESPLQPSELQPH---YVA 1720
PD N L T E G + + P E+ S L PH Y+A
Sbjct: 1150 TAAPDACD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQS-LCPHGRGYLA 1206
Query: 1721 SHPEPPAGFEGLQ--AEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVN 1776
P+G L+ +EC + C++G CV GY+C C G+ + C+D +
Sbjct: 1207 -----PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1261
Query: 1777 ECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
EC D PA C G C NT GSY C C P V + C + E
Sbjct: 1262 ECAD-EEPA--CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNE 1303
Score = 43.1 bits (100), Expect = 0.002
Identities = 48/186 (25%), Positives = 58/186 (31%), Gaps = 72/186 (38%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP--------------PCQNRGSCSRPQLC--- 207
G +CG Q C ++ P C+P C+NR C +C
Sbjct: 976 GPEICGAQRCEN----TPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1031
Query: 208 ------VCRSGFRGAR----------------------CEEV-------IPD--EEFDPQ 230
+C G+ GAR CE V P+ EEFDP
Sbjct: 1032 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1091
Query: 231 NSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQ 290
R P R GT +QP AP SP P PP L T P Q
Sbjct: 1092 TGRCVPPR-------------TSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST-PRQG 1137
Query: 291 HVGLSR 296
VG R
Sbjct: 1138 PVGSGR 1143
Score = 41.2 bits (95), Expect = 0.009
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
C GF+ + +C DV+EC C HG C NT G Y C C G++ ++ C
Sbjct: 307 CPTGFE--RVNGSCEDVDEC----ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 360
Query: 1819 AK 1820
++
Sbjct: 361 SQ 362
Score = 36.2 bits (82), Expect = 0.30
Identities = 36/136 (26%), Positives = 48/136 (35%), Gaps = 24/136 (17%)
Query: 111 QSRRVQPPAQTRRSTPLGQQQPA-------PRTRAAPALPRLGTPQRSGAAPPTPPRGRL 163
+ RRV PP R + P P RA P PP GR
Sbjct: 553 ECRRVPPPCAPGRC----ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 608
Query: 164 T---GRNVC----GGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGF 213
G +C G Q P + + C + P RG+C CVC +GF
Sbjct: 609 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGACKNLPGSFRCVCPAGF 665
Query: 214 RGARCEEVIPDEEFDP 229
RG+ CEE + + +P
Sbjct: 666 RGSACEEDVDECAQEP 681
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 1110 bits (2870), Expect = 0.0
Identities = 623/1551 (40%), Positives = 782/1551 (50%), Gaps = 219/1551 (14%)
Query: 400 CQIPCLNGGRCIGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFT 459
C + C NGG C+ D C CP + GKFC L G+RP A L +S +T
Sbjct: 153 CPLICHNGGVCVKPDRCLCPPDFAGKFCQLH---------SSGARPPAPAVPGLTRSVYT 203
Query: 460 LPLSNQLASVN--PSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPA 517
+PL+N + S+V VH+ HP EASV +HQV +V G EEA E
Sbjct: 204 MPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAA---- 259
Query: 518 SPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGL-----LGRCYLNTVNGQCANPLLELTT 572
A + P L +APR G G C+ G+CA+PL L T
Sbjct: 260 ------------RAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECASPLPGLRT 307
Query: 573 QEDCCGSVGAFWGVTLCAPCPPRPA-SPVIENGQLECPQGYKRLNLTHCQDINECLTLGL 631
QE CC G WGV C C R S + CP G++R+N + C+D++EC T G
Sbjct: 308 QEVCCRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERVNGS-CEDVDECATGGR 366
Query: 632 CKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRI 691
C+ EC NTRG Y C C G +LD SRS C+S IS +G C+R L G C+LP+ + I
Sbjct: 367 CQHGECANTRGGYTCVCPDGFLLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNI 426
Query: 692 TKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELAR 751
TKQICCCSRVGKAWG C+ CP G+E FREICPAG GY Y++SD+R + R +E
Sbjct: 427 TKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQE---- 482
Query: 752 PPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGN 811
PPR + PA +P T + D + G + PAW
Sbjct: 483 PPRVSLSQPRTL---PATSRPSAGFLPTHRLEPRPEPRPDPRPGP-ELPLPSIPAW---- 534
Query: 812 ATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCV 871
T P +PE G P C VCGPG C++ P GY C
Sbjct: 535 -TGPEIPESG---------------------PSSGMCQRNP-QVCGPGRCISRPSGYTCA 571
Query: 872 CSPGYQLHPSQAYCTDDNECLR--DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQ 929
C G++L P C D +EC R PC GRC N GS+ C C PG+ A EC
Sbjct: 572 CDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAA--ECL 628
Query: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINEC-RHPGTCPDGRCV 986
D++EC + P C G+C NT GS+ C C GY G CQD++EC + PG C G C
Sbjct: 629 DVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACK 688
Query: 987 NSPGSYTCLACEEGYRGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSD 1045
N PGS+ C+ C G+RG S DV+EC P C G+C N GSF C+C G+
Sbjct: 689 NLPGSFRCV-CPAGFRG-SACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 746
Query: 1046 EKGCQDVDECA-SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCP 1104
CQDVDECA S C G C NTEGSF C C G+ N G+ CED+DEC CP
Sbjct: 747 GAPCQDVDECARSPPPCTYGRCENTEGSFQC-VCPMGFQPNTAGSECEDVDECENHLACP 805
Query: 1105 SGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCP 1163
C N+ GSF C+ C G+ C DVDEC C G C NT GS++C C
Sbjct: 806 GQECVNSPGSFQCRTCPSGHHLHR--GRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCA 863
Query: 1164 QGFQLANGTV--CEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221
G++ +G C DVNEC+ + C PHGECLN+ GSF C CAPG+ G SC DVDE
Sbjct: 864 PGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDE 923
Query: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPG 1281
C+ D C G C NT+GSF C+C G + P+ C+D+DEC + G +CG+ +CENSPG
Sbjct: 924 CSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 983
Query: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECA--------------------------------- 1308
SYRCV C PG+H P G C D+DEC
Sbjct: 984 SYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTP 1043
Query: 1309 -----------NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCG 1357
N + CG+H C N GSF+CLCDQG+E + G CVDVNECE + VCG
Sbjct: 1044 GGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCG 1103
Query: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQ---SMSEAPTGDHAPA------ 1407
AALCENVEGSFLC+C + EE+D G C PR + G S +AP PA
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1163
Query: 1408 --------------PTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--C 1451
R +CY C ++L RN T ECCCT G WG C + C
Sbjct: 1164 LPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQC 1223
Query: 1452 PSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVC 1511
P ++AE+ +CP G+GY+ G ++ D DEC +F +C +G C+NT PGY C
Sbjct: 1224 PGTETAEYQSLCPHGRGYLAPSG----DLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSC 1279
Query: 1512 LCNPGFHYDASHKKCEDHDECQD--LACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNS 1569
C+ G++Y +C D+DEC D ACE G CVNT GS+HC C PPL LD SQ+RC+++
Sbjct: 1280 YCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSN 1339
Query: 1570 TSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRS 1628
S + D ++ +CW++V D VCS P + TYTECCC GEAW CALCP +
Sbjct: 1340 ESQS-----LDDNLGVCWQEVGADLVCSHPRLDRQATYTECCCLYGEAWGMDCALCPAQD 1394
Query: 1629 SEVYAQLCNVARIEAEREAGVHFRPG-----YEYGPG----------------PDDLHYS 1667
S+ + LCNV R A RPG YEYGP P L Y
Sbjct: 1395 SDDFEALCNVLRPPAYSPP----RPGGFGLPYEYGPDLGPPYQGLPYGPELYPPPALPYD 1450
Query: 1668 IYGPDGAPFYNYLGP-------------------EDTVPEPAFPNTAG--HSADRTPILE 1706
Y P PF P E P P P T S D
Sbjct: 1451 PYPPPPGPFARREAPYGAPRFDMPDFEDDGGPYGESEAPAPPGPGTRWPYRSRDTRRSFP 1510
Query: 1707 SPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLD 1766
P +P E Y S EP +E L+AEECGIL+GC NGRCVRV EG+TC CF+G++LD
Sbjct: 1511 EPEEPPE-GGSYAGSLAEP---YEELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLD 1566
Query: 1767 AAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
MACVD+NECD+ + LCV+ C NT+GS+RC C PG+ P HC
Sbjct: 1567 MTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRPGFAPTHQPHHC 1617
Score = 306 bits (783), Expect = 2e-82
Identities = 258/825 (31%), Positives = 341/825 (41%), Gaps = 140/825 (16%)
Query: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
P VC G C + ++C CD G+R SP G C DVDEC C G C+N+ GS++
Sbjct: 553 PQVCGPGRCISRPSGYTCA-CDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFR 611
Query: 1160 CLCPQGFQLA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
C+C GF+ C DV+EC G C N+ GSF C+C G+ +A G SCQD
Sbjct: 612 CVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQD 671
Query: 1219 VDECATTDP--CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKC 1276
VDEC T P C G C N GSF C+C GF+ S D+DEC P CG +C
Sbjct: 672 VDEC-TQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEE---DVDECAQEPPP-CGPGRC 726
Query: 1277 ENSPGSYRCVLGCQPGFHM-APNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
+N+ GS+ C C GF P C D+DECA ++G C+NT+GSF+C+C GF+
Sbjct: 727 DNTAGSFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQ 784
Query: 1336 ISPSGWDCVDVNECELMLAVCGAALCENVEGSFLC-LCAS----------DLEEYDAQEG 1384
+ +G +C DV+ECE LA C C N GSF C C S D++E +
Sbjct: 785 PNTAGSECEDVDECENHLA-CPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP 843
Query: 1385 HCRPRG-----AGGQSMS-----EAPTGDHAPAPTRMDCYSGQK--GHAPCSSVLGRNTT 1432
C P G G S AP+G P +C G H C + G
Sbjct: 844 PCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNTDG---- 899
Query: 1433 QAECCCTQGASWG---------DAC---DLCPS----EDSAEFSEICPSGKGYIPVEGAW 1476
C C G G D C DLC S F ICP G P
Sbjct: 900 SFACTCAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGP----- 954
Query: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCL--CNPGFHYDASHKKCEDHDECQD 1534
D DEC GP LC + RC N+ Y C+ C+PG+H C+D DECQ+
Sbjct: 955 --DLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHA-GPEGTCDDVDECQE 1011
Query: 1535 LA---CENGECVNTEGSFHCF--CSPPLT---------LDLSQQR--------CMNSTSS 1572
C C NT GS+ C C P +D + R C N S
Sbjct: 1012 YGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNLPGS 1071
Query: 1573 TEDLPD----------HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-EAWSQQC 1621
+ L D H + ++ C + VC L + C C + E +
Sbjct: 1072 FQCLCDQGYEGARDGRHCVDVNEC--ETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMT 1129
Query: 1622 ALC-PPRSSEVYAQLCNVARIEAEREAGVHFRPGYE-------------YGPGPDDLHYS 1667
C PPR+S A ++ +A + RP G G + ++
Sbjct: 1130 GRCVPPRTS---AGTFPGSQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFD 1186
Query: 1668 IYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA----DRTPILESPLQPSELQPH---YVA 1720
PD N L T E G + + P E+ S L PH Y+A
Sbjct: 1187 TAAPDACD--NILARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEYQS-LCPHGRGYLA 1243
Query: 1721 SHPEPPAGFEGLQ--AEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVN 1776
P+G L+ +EC + C++G CV GY+C C G+ + C+D +
Sbjct: 1244 -----PSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDND 1298
Query: 1777 ECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
EC D PA C G C NT GSY C C P V + C + E
Sbjct: 1299 ECAD-EEPA--CEGGRCVNTVGSYHCTCEPPLVLDGSQRRCVSNE 1340
Score = 43.1 bits (100), Expect = 0.002
Identities = 48/186 (25%), Positives = 58/186 (31%), Gaps = 72/186 (38%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP--------------PCQNRGSCSRPQLC--- 207
G +CG Q C ++ P C+P C+NR C +C
Sbjct: 1013 GPEICGAQRCEN----TPGSYRCTPACDPGYQPTPGGGCQDVDECRNRSFCGAHAVCQNL 1068
Query: 208 ------VCRSGFRGAR----------------------CEEV-------IPD--EEFDPQ 230
+C G+ GAR CE V P+ EEFDP
Sbjct: 1069 PGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPM 1128
Query: 231 NSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQTHPSQQ 290
R P R GT +QP AP SP P PP L T P Q
Sbjct: 1129 TGRCVPPR-------------TSAGTFPGSQPQAPASPVLPARPPPPPLPRRPST-PRQG 1174
Query: 291 HVGLSR 296
VG R
Sbjct: 1175 PVGSGR 1180
Score = 41.2 bits (95), Expect = 0.009
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
C GF+ + +C DV+EC C HG C NT G Y C C G++ ++ C
Sbjct: 344 CPTGFE--RVNGSCEDVDEC----ATGGRCQHGECANTRGGYTCVCPDGFLLDSSRSSCI 397
Query: 1819 AK 1820
++
Sbjct: 398 SQ 399
Score = 36.2 bits (82), Expect = 0.30
Identities = 36/136 (26%), Positives = 48/136 (35%), Gaps = 24/136 (17%)
Query: 111 QSRRVQPPAQTRRSTPLGQQQPA-------PRTRAAPALPRLGTPQRSGAAPPTPPRGRL 163
+ RRV PP R + P P RA P PP GR
Sbjct: 590 ECRRVPPPCAPGRC----ENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRC 645
Query: 164 T---GRNVC----GGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGF 213
G +C G Q P + + C + P RG+C CVC +GF
Sbjct: 646 ENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ---SPGLCGRGACKNLPGSFRCVCPAGF 702
Query: 214 RGARCEEVIPDEEFDP 229
RG+ CEE + + +P
Sbjct: 703 RGSACEEDVDECAQEP 718
>gi|194328809 latent transforming growth factor beta binding protein 3
isoform 1 [Homo sapiens]
Length = 1303
Score = 759 bits (1959), Expect = 0.0
Identities = 478/1355 (35%), Positives = 632/1355 (46%), Gaps = 280/1355 (20%)
Query: 349 KKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK--SGFRIYFCQIPCLN 406
++ K+VF P ICK+TC +G C +SC++G TL + GH D SGFR+ C +PC+N
Sbjct: 60 ERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMN 119
Query: 407 GGRCIGRDECWCPANSTGKFCHLP-----------------------------IPQPD-- 435
GG+C R++C CP + TG+FC +P P+ D
Sbjct: 120 GGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSV 179
Query: 436 ------------REPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVN----PSLVKVHIH 479
+PPG G P P + + F +PL S P +V V +H
Sbjct: 180 ASKHAIYAVQVIADPPGPGEGP------PAQHAAFLVPLGPGQISAEVQAPPPVVNVRVH 233
Query: 480 HPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRP 539
HPPEASVQ+H++ N+ P L P +P P
Sbjct: 234 HPPEASVQVHRIES----------SNAESAAPSQHLLPHP---------------KPSHP 268
Query: 540 LPPAAPRPRGLLGRCYLNTVNGQ-C-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPA 597
PP +P LGRC+ +T+ Q C +NPL LT QEDCCGS+G WG + C CP
Sbjct: 269 RPP-TQKP---LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY 324
Query: 598 SPVIENGQL------ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG 651
+ V + G + +CPQGYKRLN THCQDINEC G+C+ +C+N GSY C C PG
Sbjct: 325 TGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
Query: 652 LMLDPSRSRCVSDKAISMLQGLCYRSLGP-GTCTLPLAQRITKQICCCSRVGKAWGSECE 710
L PSR++C++DK + LC+R + P C PL R+T+Q+CCCS VGKAWG+ C+
Sbjct: 385 HSLGPSRTQCIADKPEE--KSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQ 441
Query: 711 KCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEEL-----ARPPREQGQRSSGALP 765
+CP GT AF+EICPAG GY +S L+++ + L P +Q S P
Sbjct: 442 RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAP 501
Query: 766 GPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPM-------- 817
P + + R VT ++ ++ Q+ T+ P + +PP
Sbjct: 502 PPEDTEEERGVT---TDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDL 558
Query: 818 -PEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGY 876
P + EI QVT + D C N+CG G CV P Y C C+PGY
Sbjct: 559 PPSRSAVEIAPTQVTET------------DECRLN-QNICGHGECVPGPPDYSCHCNPGY 605
Query: 877 QLHPSQAYCTDDNECLRDPC-KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE 935
+ HP YC D NEC +PC G+G C+N GSY+C C GY L + C D+NEC
Sbjct: 606 RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
Query: 936 QPGVC-SGGQCTNTEGSYHCECDQGYIM--VRKGHCQDINECRHPGTCPDGRCVNSPGSY 992
+P +C GG C N G Y C C GY + R C+DI+ECR P +CPDG+C N PGS+
Sbjct: 666 KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSF 725
Query: 993 TCLACEEGYRGQ-SGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD 1051
C+AC+ GYR Q G+C DVNEC C+ G C NL GSFRC+C QGY D + C D
Sbjct: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
Query: 1052 VDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNT 1111
VDEC + C G+C NT GSF C C +GY ++ D + CED+DEC FP C G C NT
Sbjct: 786 VDECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
Query: 1112 AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLAN 1170
GS+ C C G+R G C+D+DEC S CL G CKN GSY C+C +GF
Sbjct: 845 NGSYRCL-CPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF---- 898
Query: 1171 GTVCEDVNECMGEEHCAPHGEC-LNSHGSFF-------------CLCA------------ 1204
T +D + C E EC LN + F C C+
Sbjct: 899 -TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957
Query: 1205 --PGFVSAEGGTSC--------------------QDVDECAT--TDPCVGGHCVNTEGSF 1240
P + SAE + C +D+DEC ++ C G CVNT+ +
Sbjct: 958 PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017
Query: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAP--- 1297
C C+ GF ECVD+DEC D + C CEN+ G YRC C P +P
Sbjct: 1018 ECYCKQGFYYDGNLLECVDVDECLDESN--CRNGVCENTRGGYRC--ACTPPAEYSPAQR 1073
Query: 1298 ---NGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLA 1354
+ + +D+DEC + C G C N GS+RC C + PSG DC + E A
Sbjct: 1074 QCLSPEEMDVDECQDPAAC-RPGRCVNLPGSYRCECRPPWVPGPSGRDC-QLPESPAERA 1131
Query: 1355 VCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCY 1414
+C + G ++G C AG PA T DC
Sbjct: 1132 PERRDVCWSQRG---------------EDGMCAGPLAG-------------PALTFDDC- 1162
Query: 1415 SGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCP-----------SEDSAEFSEIC 1463
CC QG WG C CP +S F +
Sbjct: 1163 ----------------------CCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTS 1200
Query: 1464 PSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASH 1523
P G P + + D+DEC C +GRC+ G VC C GF DAS
Sbjct: 1201 PLLLGKPPRD-----EDSSEEDSDEC------RCVSGRCVPRPGGAVCECPGGFQLDASR 1249
Query: 1524 KKCEDHDECQD-----LACENGECVNTEGSFHCFC 1553
+C D DEC++ L C++ CVNT GSF C C
Sbjct: 1250 ARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVC 1284
Score = 416 bits (1070), Expect = e-116
Identities = 265/792 (33%), Positives = 361/792 (45%), Gaps = 136/792 (17%)
Query: 1051 DVDECASRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPS-GVC 1108
+ DEC + C G C+ ++C C GY + C D++EC P G+C
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYSCH-CNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 1109 TNTAGSFSCKDCDGGYR--PSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGF 1166
NT GS++C C+ GYR G SC D++EC P GG C N G Y+C C G+
Sbjct: 633 MNTGGSYNCH-CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY 691
Query: 1167 QL--ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCL-CAPGFVSAEGGTSCQDVDECA 1223
+L + VCED++EC C P G+C N GSF C+ C PG+ S +GG +C+DV+ECA
Sbjct: 692 RLKASRPPVCEDIDECRDPSSC-PDGKCENKPGSFKCIACQPGYRS-QGGGACRDVNECA 749
Query: 1224 TTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSY 1283
PC G C N GSF C C G+ P+P+ C+D+DECE GD VC C N+PGS+
Sbjct: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GD-VCDNGICSNTPGSF 807
Query: 1284 RCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWD 1342
+C C G+H++ + C DIDEC C G C NT+GS+RCLC QG + G
Sbjct: 808 QCQ--CLSGYHLSRDRSHCEDIDECDFPAACIG-GDCINTNGSYRCLCPQGHRLV-GGRK 863
Query: 1343 CVDVNECELMLAVC---GAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA 1399
C D++EC ++C GA C+N++GS++C+C Q G E
Sbjct: 864 CQDIDECSQDPSLCLPHGA--CKNLQGSYVCVCDEGFTPTQDQHG-----------CEEV 910
Query: 1400 PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSEDSA 1457
H + +CY C SVL N TQ ECCC+ GA WGD C++ CP SA
Sbjct: 911 EQPHH-----KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSA 965
Query: 1458 EFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGF 1517
EF +CP GKGY +G + D DEC++FG +C G+C+NT PGY C C GF
Sbjct: 966 EFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGF 1025
Query: 1518 HYDASHKKCEDHDECQDLA-CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTED- 1575
+YD + +C D DEC D + C NG C NT G + C C+PP +Q++C++ D
Sbjct: 1026 YYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDE 1085
Query: 1576 -------------------------------------LPDHDIHM-----DICWKKVTND 1593
LP+ D+CW + D
Sbjct: 1086 CQDPAACRPGRCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGED 1145
Query: 1594 -VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFR 1652
+C+ PL G T+ +CCC+ G W QC CPPR AG H
Sbjct: 1146 GMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG------------------AGSHC- 1186
Query: 1653 PGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPS 1712
P S D +P P D +++ +D E
Sbjct: 1187 --------PTSQSESNSFWDTSPLLLGKPPRDE-------DSSEEDSD-----ECRCVSG 1226
Query: 1713 ELQPHYVASHPEPPAGFE-------GLQAEECGILNG----CENGRCVRVREGYTCDCFE 1761
P + E P GF+ + +EC LN C++ RCV + C C
Sbjct: 1227 RCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKA 1286
Query: 1762 GFQLDAAHMACV 1773
GF H ACV
Sbjct: 1287 GFARSRPHGACV 1298
Score = 279 bits (714), Expect = 2e-74
Identities = 201/613 (32%), Positives = 260/613 (42%), Gaps = 131/613 (21%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCV-CSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903
ID C ++ C G C N P ++C+ C PGY+ A C D NEC G C
Sbjct: 704 IDECRDPSS--CPDGKCENKPGSFKCIACQPGYRSQGGGA-CRDVNECAEGSPCSPGWCE 760
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
N GS+ C C GY A G + C D++ECE VC G C+NT GS+ C+C GY +
Sbjct: 761 NLPGSFRCTCAQGYAPAPDG--RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLS 818
Query: 964 R-KGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSG-SCVDVNECLT-PGVC 1020
R + HC+DI+EC P C G C+N+ GSY CL C +G+R G C D++EC P +C
Sbjct: 819 RDRSHCEDIDECDFPAACIGGDCINTNGSYRCL-CPQGHRLVGGRKCQDIDECSQDPSLC 877
Query: 1021 A-HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD------ECA----SRASCPTGLCLNT 1069
HG C NL+GS+ C C++G+ T D+ GC++V+ EC C + L N
Sbjct: 878 LPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNV 937
Query: 1070 EGSFAC-------------------------SACENGYWVNEDGT-------ACEDLDEC 1097
C S C +G +D A D+DEC
Sbjct: 938 TQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDEC 997
Query: 1098 AFPG--VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
G +C G C NT + C G Y L + C DVDEC D +S+C G C+NT
Sbjct: 998 MLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLE-CVDVDECLD-ESNCRNGVCENTR 1055
Query: 1156 GSYQCLC--PQGFQLANGTVCE----DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVS 1209
G Y+C C P + A DV+EC C P G C+N GS+ C C P +V
Sbjct: 1056 GGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRP-GRCVNLPGSYRCECRPPWVP 1114
Query: 1210 AEGGTSCQ-------------DV----------------------DEC---------ATT 1225
G CQ DV D+C A
Sbjct: 1115 GPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQC 1174
Query: 1226 DPC----VGGHCVNTEGSFNCLCET-----GFQPSPESGECVDIDECEDYGDPVCGTWKC 1276
PC G HC ++ N +T G P E D DEC C + +C
Sbjct: 1175 RPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSSEEDSDECR------CVSGRC 1228
Query: 1277 ENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN----DTMCGSHGFCDNTDGSFRCLCD 1331
PG C C GF + A C+DIDEC +C S C NT GSFRC+C
Sbjct: 1229 VPRPGGAVCE--CPGGFQLDASRARCVDIDECRELNQRGLLCKSER-CVNTSGSFRCVCK 1285
Query: 1332 QGFEISPSGWDCV 1344
GF S CV
Sbjct: 1286 AGFARSRPHGACV 1298
Score = 232 bits (592), Expect = 2e-60
Identities = 225/865 (26%), Positives = 323/865 (37%), Gaps = 166/865 (19%)
Query: 997 CEEGY-RGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
C +GY R S C D+NEC PGVC HG C N GS+RC C G+ + C D+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKP 399
Query: 1056 ASRASC-----PTGLC---LNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV 1107
++ C P C L T + C G C AF +CP+G
Sbjct: 400 EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK 459
Query: 1108 CTNTAGSFSCKDC------------DGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
+ S DG +P L +S ED + G ++
Sbjct: 460 GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE--RGVTTDSP 517
Query: 1156 GSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAE--GG 1213
S + Q A T E + P + +F P SA
Sbjct: 518 VSEERSVQQSHPTATTTPARPYPELISR----PSPPTMR----WFLPDLPPSRSAVEIAP 569
Query: 1214 TSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCG 1272
T + DEC G G CV ++C C G++ P+ CVD++ECE +P CG
Sbjct: 570 TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEP-CG 626
Query: 1273 TWK--CENSPGSYRCVLGCQPGF--HMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFR 1327
+ C N+ GSY C C G+ H+ G C+D++ECA +CG GFC N G ++
Sbjct: 627 PGRGICMNTGGSYNC--HCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYK 684
Query: 1328 CLCDQGFEISPSGWD-CVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC 1386
C C G+ + S C D++EC + C CEN GSF C+ Q G+
Sbjct: 685 CNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIAC--------QPGYR 735
Query: 1387 RPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA-ECCCTQGASWG 1445
G + ++E G +PCS N + C C QG +
Sbjct: 736 SQGGGACRDVNECAEG------------------SPCSPGWCENLPGSFRCTCAQGYA-- 775
Query: 1446 DACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNT 1505
P G+ + D DEC +C NG C NT
Sbjct: 776 ----------------PAPDGRSCL--------------DVDECE--AGDVCDNGICSNT 803
Query: 1506 VPGYVCLCNPGFHYDASHKKCEDHDECQ-DLACENGECVNTEGSFHCFCSPPLTLDLSQQ 1564
+ C C G+H CED DEC AC G+C+NT GS+ C C L + +
Sbjct: 804 PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGR 862
Query: 1565 RCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC 1624
+C + ++D +C + + C L+G C C +G +Q C
Sbjct: 863 KCQDIDECSQD-------PSLC---LPHGACKN-LQGSYV----CVCDEGFTPTQDQHGC 907
Query: 1625 -----PPRSSEVYAQLCNVARIEAEREAGVHFRPGY-EYGPGPDDLHYSIYGPDGAPFYN 1678
P E Y + ++ V + G G D H IY
Sbjct: 908 EEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD-HCEIY--------- 957
Query: 1679 YLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECG 1738
P P + + HS P + Q + + + + +H + +EC
Sbjct: 958 --------PCPVYSSAEFHSL--CPDGKGYTQDNNIVNYGIPAHRD---------IDECM 998
Query: 1739 ILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENT 1796
+ C+ G+CV + GY C C +GF D + CVDV+EC D + C +G CENT
Sbjct: 999 LFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN----CRNGVCENT 1054
Query: 1797 EGSYRCHCSPGYVAEAGPPHCTAKE 1821
G YRC C+P C + E
Sbjct: 1055 RGGYRCACTPPAEYSPAQRQCLSPE 1079
Score = 134 bits (337), Expect = 8e-31
Identities = 124/463 (26%), Positives = 183/463 (39%), Gaps = 104/463 (22%)
Query: 1391 AGGQSMSEAPTGDHAPAPTRMD---CYSGQKGHAPC-SSVLGRNTTQAECCCTQGASWGD 1446
A Q + P H PT+ C+ PC S+ L T Q +CC + G +WG
Sbjct: 254 APSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQ 313
Query: 1447 A-CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLN 1504
+ C CP +++ + G PV G AD CP G + LN
Sbjct: 314 SKCHKCPQ---LQYTGVQKPG----PVRGE--------VGAD---------CPQGYKRLN 349
Query: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDEC-QDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563
+ C+D +EC C +G+C+N GS+ C C P +L S+
Sbjct: 350 ST------------------HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
Query: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCA 1622
+C+ D P+ +C++ V+ + C PL R T CCC G+AW +C
Sbjct: 392 TQCI------ADKPEEK---SLCFRLVSPEHQCQHPLTT-RLTRQLCCCSVGKAWGARCQ 441
Query: 1623 LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIY-GPDGAPFYNYL- 1680
CP + + ++C + G H ++ + +S++ PDG P L
Sbjct: 442 RCPTDGTAAFKEICPAGK-------GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLP 494
Query: 1681 -------GPEDTVPEPAFPNTAGHSADRTPILESP---LQPSELQPHYVASHPEPP---- 1726
PEDT E + S +R+ P P+ P + S P PP
Sbjct: 495 ESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELI-SRPSPPTMRW 553
Query: 1727 --------------AGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771
A + + +EC + N C +G CV Y+C C G++ H
Sbjct: 554 FLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRY 613
Query: 1772 CVDVNECD-DLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAG 1813
CVDVNEC+ + GP G C NT GSY CHC+ GY G
Sbjct: 614 CVDVNECEAEPCGPG----RGICMNTGGSYNCHCNRGYRLHVG 652
Score = 63.5 bits (153), Expect = 2e-09
Identities = 55/207 (26%), Positives = 68/207 (32%), Gaps = 68/207 (32%)
Query: 512 PPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNT-VNGQCANPLL-E 569
PPW+P G R + P AP R + C+ +G CA PL
Sbjct: 1110 PPWVPGPSG-----------RDCQLPESPAERAPERRDV---CWSQRGEDGMCAGPLAGP 1155
Query: 570 LTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQ------------------------ 605
T +DCC G WG C PCPPR A Q
Sbjct: 1156 ALTFDDCCCRQGRGWGAQ-CRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1214
Query: 606 ----------------------LECPQGYKR-LNLTHCQDINECLTLG----LCKDAECV 638
ECP G++ + C DI+EC L LCK CV
Sbjct: 1215 EEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCV 1274
Query: 639 NTRGSYLCTCRPGLMLDPSRSRCVSDK 665
NT GS+ C C+ G CV +
Sbjct: 1275 NTSGSFRCVCKAGFARSRPHGACVPQR 1301
Score = 48.1 bits (113), Expect = 8e-05
Identities = 45/152 (29%), Positives = 56/152 (36%), Gaps = 44/152 (28%)
Query: 1706 ESPLQPSELQPHYVASHPEPPAG--------------------FEGLQAEE--CGILNGC 1743
ES L PH SHP PP GL +E CG +
Sbjct: 251 ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310
Query: 1744 -ENGRCVR--------------VREGYTCDCFEGFQ-LDAAHMACVDVNECDDLNGPAVL 1787
+C + VR DC +G++ L++ H C D+NEC P V
Sbjct: 311 WGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTH--CQDINECAM---PGV- 364
Query: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTA 1819
C HG C N GSYRC C PG+ C A
Sbjct: 365 CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIA 396
Score = 41.2 bits (95), Expect = 0.009
Identities = 53/199 (26%), Positives = 67/199 (33%), Gaps = 45/199 (22%)
Query: 190 VCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRS 249
VC PC N G CS C+C F G C+ +P + A P L R+
Sbjct: 112 VCPLPCMNGGQCSSRNQCLCPPDFTGRFCQ--VP--------AGGAGGGTGGSGPGLSRT 161
Query: 250 SAAGEGTLARAQPPAPQ--------------SPPAP-QSPPAGTLSGLSQTHPSQQHVGL 294
A G L P PP P + PPA + L P Q +
Sbjct: 162 GALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV 221
Query: 295 SR-----TVRLHPTATASSQL----SSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLT 345
VR+H AS Q+ SSNA P +Q +P PS P
Sbjct: 222 QAPPPVVNVRVHHPPEASVQVHRIESSNAESAAP-------SQHLLPHPKPSHP----RP 270
Query: 346 EKIKKIKIVFTPTICKQTC 364
K + F T+ KQ C
Sbjct: 271 PTQKPLGRCFQDTLPKQPC 289
>gi|18497288 latent transforming growth factor beta binding protein 3
isoform 2 [Homo sapiens]
Length = 1256
Score = 693 bits (1789), Expect = 0.0
Identities = 452/1311 (34%), Positives = 601/1311 (45%), Gaps = 253/1311 (19%)
Query: 349 KKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPK--SGFRIYFCQIPCLN 406
++ K+VF P ICK+TC +G C +SC++G TL + GH D SGFR+ C +PC+N
Sbjct: 60 ERFKVVFAPVICKRTCLKGQCRDSCQQGSNMTLIGENGHSTDTLTGSGFRVVVCPLPCMN 119
Query: 407 GGRCIGRDECWCPANSTGKFCHLP-----------------------------IPQPD-- 435
GG+C R++C CP + TG+FC +P P+ D
Sbjct: 120 GGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSGPGLSRTGALSTGALPPLAPEGDSV 179
Query: 436 ------------REPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVN----PSLVKVHIH 479
+PPG G P P + + F +PL S P +V V +H
Sbjct: 180 ASKHAIYAVQVIADPPGPGEGP------PAQHAAFLVPLGPGQISAEVQAPPPVVNVRVH 233
Query: 480 HPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRP 539
HPPEASVQ+H++ N+ P L P +P P
Sbjct: 234 HPPEASVQVHRIES----------SNAESAAPSQHLLPHP---------------KPSHP 268
Query: 540 LPPAAPRPRGLLGRCYLNTVNGQ-C-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPA 597
PP +P LGRC+ +T+ Q C +NPL LT QEDCCGS+G WG + C CP
Sbjct: 269 RPP-TQKP---LGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQY 324
Query: 598 SPVIENGQL------ECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPG 651
+ V + G + +CPQGYKRLN THCQDINEC G+C+ +C+N GSY C C PG
Sbjct: 325 TGVQKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPG 384
Query: 652 LMLDPSRSRCVSDKAISMLQGLCYRSLGP-GTCTLPLAQRITKQICCCSRVGKAWGSECE 710
L PSR++C++DK + LC+R + P C PL R+T+Q+CCCS VGKAWG+ C+
Sbjct: 385 HSLGPSRTQCIADKPEE--KSLCFRLVSPEHQCQHPLTTRLTRQLCCCS-VGKAWGARCQ 441
Query: 711 KCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEEL-----ARPPREQGQRSSGALP 765
+CP GT AF+EICPAG GY +S L+++ + L P +Q S P
Sbjct: 442 RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAP 501
Query: 766 GPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPM-------- 817
P + + R VT ++ ++ Q+ T+ P + +PP
Sbjct: 502 PPEDTEEERGVT---TDSPVSEERSVQQSHPTATTTPARPYPELISRPSPPTMRWFLPDL 558
Query: 818 -PEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGY 876
P + EI QVT + D C N+CG G CV P Y C C+PGY
Sbjct: 559 PPSRSAVEIAPTQVTET------------DECRLN-QNICGHGECVPGPPDYSCHCNPGY 605
Query: 877 QLHPSQAYCTDDNECLRDPC-KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE 935
+ HP YC D NEC +PC G+G C+N GSY+C C GY L + C D+NEC
Sbjct: 606 RSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGRSCVDLNECA 665
Query: 936 QPGVC-SGGQCTNTEGSYHCECDQGYIM--VRKGHCQDINECRHPGTCPDGRCVNSPGSY 992
+P +C GG C N G Y C C GY + R C+DI+ECR P +CPDG+C N PGS+
Sbjct: 666 KPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSF 725
Query: 993 TCLACEEGYRGQ-SGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD 1051
C+AC+ GYR Q G+C DVNEC C+ G C NL GSFRC+C QGY D + C D
Sbjct: 726 KCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLD 785
Query: 1052 VDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNT 1111
VDEC + C G+C NT GSF C C +GY ++ D + CED+DEC FP C G C NT
Sbjct: 786 VDECEAGDVCDNGICSNTPGSFQCQ-CLSGYHLSRDRSHCEDIDECDFPAACIGGDCINT 844
Query: 1112 AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLAN 1170
GS+ C C G+R G C+D+DEC S CL G CKN GSY C+C +GF
Sbjct: 845 NGSYRCL-CPQGHRLVG-GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF---- 898
Query: 1171 GTVCEDVNECMGEEHCAPHGEC-LNSHGSFF-------------CLCA------------ 1204
T +D + C E EC LN + F C C+
Sbjct: 899 -TPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIY 957
Query: 1205 --PGFVSAEGGTSC--------------------QDVDECAT--TDPCVGGHCVNTEGSF 1240
P + SAE + C +D+DEC ++ C G CVNT+ +
Sbjct: 958 PCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGY 1017
Query: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD 1300
C C+ GF ECVD+DEC D + C CEN+ G YRC C P +P
Sbjct: 1018 ECYCKQGFYYDGNLLECVDVDECLDESN--CRNGVCENTRGGYRC--ACTPPAEYSP--- 1070
Query: 1301 CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWD-CVDVNECELMLA--VCG 1357
+CL + E +P D C + M A + G
Sbjct: 1071 -----------------------AQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAG 1107
Query: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ 1417
AL +F C + AQ C PRGAG S PT + + + D
Sbjct: 1108 PAL------TFDDCCCRQGRGWGAQCRPCPPRGAG----SHCPT-SQSESNSFWDTSPLL 1156
Query: 1418 KGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWT 1477
G P + EC C G C E CP G ++ +
Sbjct: 1157 LGKPPRDEDSSEEDSD-ECRCVSGR--------CVPRPGGAVCE-CPGG---FQLDAS-- 1201
Query: 1478 FGQTMYTDADECVIFGPG--LCPNGRCLNTVPGYVCLCNPGFHYDASHKKC 1526
+ D DEC LC + RC+NT + C+C GF H C
Sbjct: 1202 --RARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGAC 1250
Score = 432 bits (1112), Expect = e-120
Identities = 264/749 (35%), Positives = 360/749 (48%), Gaps = 97/749 (12%)
Query: 1051 DVDECASRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPS-GVC 1108
+ DEC + C G C+ ++C C GY + C D++EC P G+C
Sbjct: 574 ETDECRLNQNICGHGECVPGPPDYSCH-CNPGYRSHPQHRYCVDVNECEAEPCGPGRGIC 632
Query: 1109 TNTAGSFSCKDCDGGYR--PSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGF 1166
NT GS++C C+ GYR G SC D++EC P GG C N G Y+C C G+
Sbjct: 633 MNTGGSYNCH-CNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGY 691
Query: 1167 QL--ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCL-CAPGFVSAEGGTSCQDVDECA 1223
+L + VCED++EC C P G+C N GSF C+ C PG+ S +GG +C+DV+ECA
Sbjct: 692 RLKASRPPVCEDIDECRDPSSC-PDGKCENKPGSFKCIACQPGYRS-QGGGACRDVNECA 749
Query: 1224 TTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSY 1283
PC G C N GSF C C G+ P+P+ C+D+DECE GD VC C N+PGS+
Sbjct: 750 EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEA-GD-VCDNGICSNTPGSF 807
Query: 1284 RCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWD 1342
+C C G+H++ + C DIDEC C G C NT+GS+RCLC QG + G
Sbjct: 808 QCQ--CLSGYHLSRDRSHCEDIDECDFPAACIG-GDCINTNGSYRCLCPQGHRLV-GGRK 863
Query: 1343 CVDVNECELMLAVC---GAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA 1399
C D++EC ++C GA C+N++GS++C+C Q G E
Sbjct: 864 CQDIDECSQDPSLCLPHGA--CKNLQGSYVCVCDEGFTPTQDQHG-----------CEEV 910
Query: 1400 PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL--CPSEDSA 1457
H + +CY C SVL N TQ ECCC+ GA WGD C++ CP SA
Sbjct: 911 EQPHH-----KKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSA 965
Query: 1458 EFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGF 1517
EF +CP GKGY +G + D DEC++FG +C G+C+NT PGY C C GF
Sbjct: 966 EFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGF 1025
Query: 1518 HYDASHKKCEDHDECQDLA-CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDL 1576
+YD + +C D DEC D + C NG C NT G + C C+PP +Q++C+ S E++
Sbjct: 1026 YYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCL----SPEEM 1081
Query: 1577 PDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL 1635
D+CW + D +C+ PL G T+ +CCC+ G W QC CPPR
Sbjct: 1082 ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG------- 1134
Query: 1636 CNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTA 1695
AG H P S D +P P D +++
Sbjct: 1135 -----------AGSHC---------PTSQSESNSFWDTSPLLLGKPPRDE-------DSS 1167
Query: 1696 GHSADRTPILESPLQPSELQPHYVASHPEPPAGFE-------GLQAEECGILNG----CE 1744
+D E P + E P GF+ + +EC LN C+
Sbjct: 1168 EEDSD-----ECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQRGLLCK 1222
Query: 1745 NGRCVRVREGYTCDCFEGFQLDAAHMACV 1773
+ RCV + C C GF H ACV
Sbjct: 1223 SERCVNTSGSFRCVCKAGFARSRPHGACV 1251
Score = 232 bits (592), Expect = 2e-60
Identities = 225/865 (26%), Positives = 323/865 (37%), Gaps = 166/865 (19%)
Query: 997 CEEGY-RGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
C +GY R S C D+NEC PGVC HG C N GS+RC C G+ + C D+
Sbjct: 341 CPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCI-ADKP 399
Query: 1056 ASRASC-----PTGLC---LNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV 1107
++ C P C L T + C G C AF +CP+G
Sbjct: 400 EEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPAGK 459
Query: 1108 CTNTAGSFSCKDC------------DGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
+ S DG +P L +S ED + G ++
Sbjct: 460 GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEE--RGVTTDSP 517
Query: 1156 GSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAE--GG 1213
S + Q A T E + P + +F P SA
Sbjct: 518 VSEERSVQQSHPTATTTPARPYPELISR----PSPPTMR----WFLPDLPPSRSAVEIAP 569
Query: 1214 TSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCG 1272
T + DEC G G CV ++C C G++ P+ CVD++ECE +P CG
Sbjct: 570 TQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECE--AEP-CG 626
Query: 1273 TWK--CENSPGSYRCVLGCQPGF--HMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFR 1327
+ C N+ GSY C C G+ H+ G C+D++ECA +CG GFC N G ++
Sbjct: 627 PGRGICMNTGGSYNC--HCNRGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYK 684
Query: 1328 CLCDQGFEISPSGWD-CVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC 1386
C C G+ + S C D++EC + C CEN GSF C+ Q G+
Sbjct: 685 CNCYPGYRLKASRPPVCEDIDECRDPSS-CPDGKCENKPGSFKCIAC--------QPGYR 735
Query: 1387 RPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA-ECCCTQGASWG 1445
G + ++E G +PCS N + C C QG +
Sbjct: 736 SQGGGACRDVNECAEG------------------SPCSPGWCENLPGSFRCTCAQGYA-- 775
Query: 1446 DACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNT 1505
P G+ + D DEC +C NG C NT
Sbjct: 776 ----------------PAPDGRSCL--------------DVDECE--AGDVCDNGICSNT 803
Query: 1506 VPGYVCLCNPGFHYDASHKKCEDHDECQ-DLACENGECVNTEGSFHCFCSPPLTLDLSQQ 1564
+ C C G+H CED DEC AC G+C+NT GS+ C C L + +
Sbjct: 804 PGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRL-VGGR 862
Query: 1565 RCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC 1624
+C + ++D +C + + C L+G C C +G +Q C
Sbjct: 863 KCQDIDECSQD-------PSLC---LPHGACKN-LQGSYV----CVCDEGFTPTQDQHGC 907
Query: 1625 -----PPRSSEVYAQLCNVARIEAEREAGVHFRPGY-EYGPGPDDLHYSIYGPDGAPFYN 1678
P E Y + ++ V + G G D H IY
Sbjct: 908 EEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGD-HCEIY--------- 957
Query: 1679 YLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECG 1738
P P + + HS P + Q + + + + +H + +EC
Sbjct: 958 --------PCPVYSSAEFHSL--CPDGKGYTQDNNIVNYGIPAHRD---------IDECM 998
Query: 1739 ILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENT 1796
+ C+ G+CV + GY C C +GF D + CVDV+EC D + C +G CENT
Sbjct: 999 LFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESN----CRNGVCENT 1054
Query: 1797 EGSYRCHCSPGYVAEAGPPHCTAKE 1821
G YRC C+P C + E
Sbjct: 1055 RGGYRCACTPPAEYSPAQRQCLSPE 1079
Score = 214 bits (546), Expect = 5e-55
Identities = 156/517 (30%), Positives = 209/517 (40%), Gaps = 113/517 (21%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
++ CA G+ C PG C NLP +RC C+ GY P C D +EC G C N
Sbjct: 745 VNECAEGSP--CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSN 802
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
GS+ C C GY L+ + C+DI+EC+ P C GG C NT GSY C C QG+ +V
Sbjct: 803 TPGSFQCQCLSGYHLSRDRS--HCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVG 860
Query: 965 KGHCQDINEC-RHPGTC-PDGRCVNSPGSYTCLACEEGY---RGQSGSCVDVN------E 1013
CQDI+EC + P C P G C N GSY C+ C+EG+ + Q G C +V E
Sbjct: 861 GRKCQDIDECSQDPSLCLPHGACKNLQGSYVCV-CDEGFTPTQDQHG-CEEVEQPHHKKE 918
Query: 1014 C-------------LTPGVCAHGKCTNLEGSFRCSCE----------QGYEVTSDEKGC- 1049
C L V C +L + CE + + + D KG
Sbjct: 919 CYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYT 978
Query: 1050 -------------QDVDECASRAS--CPTGLCLNTEGSFACSACENGYWVNEDGTACEDL 1094
+D+DEC S C G C+NT+ + C C+ G++ + + C D+
Sbjct: 979 QDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECY-CKQGFYYDGNLLECVDV 1037
Query: 1095 DECAFPGVCPSGVCTNTAGSFSC------------KDC---------------------D 1121
DEC C +GVC NT G + C + C +
Sbjct: 1038 DECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGE 1097
Query: 1122 GGYRPSPLGDSCEDVDECEDPQSSCLGGECK----NTVGSYQCLCPQGFQLANG------ 1171
G PL D+C Q G +C+ GS+ CP +N
Sbjct: 1098 DGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRGAGSH---CPTSQSESNSFWDTSP 1154
Query: 1172 ------TVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT 1225
ED +E +E G C+ G C C GF C D+DEC
Sbjct: 1155 LLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECREL 1214
Query: 1226 DP----CVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258
+ C CVNT GSF C+C+ GF S G CV
Sbjct: 1215 NQRGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACV 1251
Score = 134 bits (337), Expect = 8e-31
Identities = 124/463 (26%), Positives = 183/463 (39%), Gaps = 104/463 (22%)
Query: 1391 AGGQSMSEAPTGDHAPAPTRMD---CYSGQKGHAPC-SSVLGRNTTQAECCCTQGASWGD 1446
A Q + P H PT+ C+ PC S+ L T Q +CC + G +WG
Sbjct: 254 APSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQ 313
Query: 1447 A-CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLN 1504
+ C CP +++ + G PV G AD CP G + LN
Sbjct: 314 SKCHKCPQ---LQYTGVQKPG----PVRGE--------VGAD---------CPQGYKRLN 349
Query: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDEC-QDLACENGECVNTEGSFHCFCSPPLTLDLSQ 1563
+ C+D +EC C +G+C+N GS+ C C P +L S+
Sbjct: 350 ST------------------HCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSR 391
Query: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTND-VCSEPLRGHRTTYTECCCQDGEAWSQQCA 1622
+C+ D P+ +C++ V+ + C PL R T CCC G+AW +C
Sbjct: 392 TQCI------ADKPEEK---SLCFRLVSPEHQCQHPLTT-RLTRQLCCCSVGKAWGARCQ 441
Query: 1623 LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIY-GPDGAPFYNYLG 1681
CP + + ++C + G H ++ + +S++ PDG P L
Sbjct: 442 RCPTDGTAAFKEICPAGK-------GYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLP 494
Query: 1682 --------PEDTVPEPAFPNTAGHSADRTPILESPLQ---PSELQPHYVASHPEPP---- 1726
PEDT E + S +R+ P P+ P + S P PP
Sbjct: 495 ESPSQAPPPEDTEEERGVTTDSPVSEERSVQQSHPTATTTPARPYPELI-SRPSPPTMRW 553
Query: 1727 --------------AGFEGLQAEECGI-LNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771
A + + +EC + N C +G CV Y+C C G++ H
Sbjct: 554 FLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGECVPGPPDYSCHCNPGYRSHPQHRY 613
Query: 1772 CVDVNECD-DLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAG 1813
CVDVNEC+ + GP G C NT GSY CHC+ GY G
Sbjct: 614 CVDVNECEAEPCGPG----RGICMNTGGSYNCHCNRGYRLHVG 652
Score = 59.7 bits (143), Expect = 3e-08
Identities = 44/158 (27%), Positives = 53/158 (33%), Gaps = 53/158 (33%)
Query: 560 NGQCANPLL-ELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQ------------- 605
+G CA PL T +DCC G WG C PCPPR A Q
Sbjct: 1098 DGMCAGPLAGPALTFDDCCCRQGRGWGAQ-CRPCPPRGAGSHCPTSQSESNSFWDTSPLL 1156
Query: 606 ---------------------------------LECPQGYKR-LNLTHCQDINECLTLG- 630
ECP G++ + C DI+EC L
Sbjct: 1157 LGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAVCECPGGFQLDASRARCVDIDECRELNQ 1216
Query: 631 ---LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
LCK CVNT GS+ C C+ G CV +
Sbjct: 1217 RGLLCKSERCVNTSGSFRCVCKAGFARSRPHGACVPQR 1254
Score = 48.1 bits (113), Expect = 8e-05
Identities = 45/152 (29%), Positives = 56/152 (36%), Gaps = 44/152 (28%)
Query: 1706 ESPLQPSELQPHYVASHPEPPAG--------------------FEGLQAEE--CGILNGC 1743
ES L PH SHP PP GL +E CG +
Sbjct: 251 ESAAPSQHLLPHPKPSHPRPPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTA 310
Query: 1744 -ENGRCVR--------------VREGYTCDCFEGFQ-LDAAHMACVDVNECDDLNGPAVL 1787
+C + VR DC +G++ L++ H C D+NEC P V
Sbjct: 311 WGQSKCHKCPQLQYTGVQKPGPVRGEVGADCPQGYKRLNSTH--CQDINECAM---PGV- 364
Query: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTA 1819
C HG C N GSYRC C PG+ C A
Sbjct: 365 CRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIA 396
Score = 41.2 bits (95), Expect = 0.009
Identities = 53/199 (26%), Positives = 67/199 (33%), Gaps = 45/199 (22%)
Query: 190 VCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRS 249
VC PC N G CS C+C F G C+ +P + A P L R+
Sbjct: 112 VCPLPCMNGGQCSSRNQCLCPPDFTGRFCQ--VP--------AGGAGGGTGGSGPGLSRT 161
Query: 250 SAAGEGTLARAQPPAPQ--------------SPPAP-QSPPAGTLSGLSQTHPSQQHVGL 294
A G L P PP P + PPA + L P Q +
Sbjct: 162 GALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGPGEGPPAQHAAFLVPLGPGQISAEV 221
Query: 295 SR-----TVRLHPTATASSQL----SSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLT 345
VR+H AS Q+ SSNA P +Q +P PS P
Sbjct: 222 QAPPPVVNVRVHHPPEASVQVHRIESSNAESAAP-------SQHLLPHPKPSHP----RP 270
Query: 346 EKIKKIKIVFTPTICKQTC 364
K + F T+ KQ C
Sbjct: 271 PTQKPLGRCFQDTLPKQPC 289
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 506 bits (1303), Expect = e-143
Identities = 291/817 (35%), Positives = 419/817 (51%), Gaps = 75/817 (9%)
Query: 849 AAGATNVCGPGTCVNLPDGYRCVC--SPGY---QLHPSQAYCTDDNECLRDPCK-GKGRC 902
AA T C N P+ Y +C PG+ ++ + + D NEC P G+C
Sbjct: 986 AAWGTEECEECPMRNTPE-YEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKC 1044
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGY- 960
N +GS+ C C G+ L + + C DI+EC P +C GQC NT G + C+CD+GY
Sbjct: 1045 RNTIGSFKCRCDSGFALDSE--ERNCTDIDECRISPDLCGRGQCVNTPGDFECKCDEGYE 1102
Query: 961 --IMVRKGHCQDINEC-RHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNEC- 1014
M+ K +C DI+EC R P C G C N+ GSY C C G++ +C+D+NEC
Sbjct: 1103 SGFMMMK-NCMDIDECQRDPLLCRGGVCHNTEGSYRC-ECPPGHQLSPNISACIDINECE 1160
Query: 1015 LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA-SRASCPTGLCLNTEGSF 1073
L+ +C +G+C NL G ++C+C GY T D C D+DEC+ C T C N+EGS+
Sbjct: 1161 LSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCET-FCTNSEGSY 1219
Query: 1074 ACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDS 1132
CS C+ G+ + D +C D+DEC P +C G CTN G + C C G+ S +
Sbjct: 1220 ECS-CQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRCL-CYDGFMASEDMKT 1277
Query: 1133 CEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANG-TVCEDVNEC-MGEEHCAPHG 1190
C DV+EC+ + CL G C+NT GS+ C C G+ G T C D+NEC +G +C H
Sbjct: 1278 CVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHA 1337
Query: 1191 ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH--CVNTEGSFNCLCETGF 1248
C N+ GSF C C+PG++ G C D+DEC+ H C NT GS+ CLC+ G+
Sbjct: 1338 VCTNTAGSFKCSCSPGWIG--DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGY 1395
Query: 1249 QPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDEC 1307
+ + C D+DEC + + +CG +C N+PG YRC C GF + +G C DIDEC
Sbjct: 1396 --TGDGFTCTDLDECSENLN-LCGNGQCLNAPGGYRCE--CDMGFVPSADGKACEDIDEC 1450
Query: 1308 ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGS 1367
+ +C G C N G FRC C+ G+E+ SG +C DVNEC L C + C N GS
Sbjct: 1451 SLPNIC-VFGTCHNLPGLFRCECEIGYELDRSGGNCTDVNEC-LDPTTCISGNCVNTPGS 1508
Query: 1368 FLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVL 1427
++C C D E + G C +G + P GD+ G CS+ +
Sbjct: 1509 YICDCPPDFELNPTRVG-CVDTRSGNCYLDIRPRGDN--------------GDTACSNEI 1553
Query: 1428 GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDAD 1487
G ++A CCC+ G +WG C++CP+ +++E+ +CP G+G+ P + D D
Sbjct: 1554 GVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPIT-----VILEDID 1608
Query: 1488 ECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA-CENGECVNTE 1546
EC PGLC G+C+NT + C C G++ + + C+D +EC+ C G C NT
Sbjct: 1609 ECQEL-PGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPGICGPGTCYNTV 1667
Query: 1547 GSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKK--VTNDVCSEPLRGHRT 1604
G++ C C P CM D+ +C++ N C L + T
Sbjct: 1668 GNYTCICPPDYMQVNGGNNCM------------DMRRSLCYRNYYADNQTCDGELLFNMT 1715
Query: 1605 TYTECCCQD-GEAWSQQCALCPPRSSEVYAQLCNVAR 1640
CC + G AW++ C CP S++ +A LC R
Sbjct: 1716 KKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQR 1752
Score = 479 bits (1233), Expect = e-134
Identities = 450/1689 (26%), Positives = 621/1689 (36%), Gaps = 367/1689 (21%)
Query: 163 LTGRNVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQL------------ 206
L G NVCG + CCPGW T N CI P+C C + G CSRP +
Sbjct: 53 LKGPNVCGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGD-GFCSRPNMCTCPSGQIAPSC 111
Query: 207 ----------------------CVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWA---- 240
C+C+ G+ G C + + + +AP R A
Sbjct: 112 GSRSIQHCNIRCMNGGSCSDDHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYG 171
Query: 241 ERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQT-------------HP 287
P R G P G LSG+ T HP
Sbjct: 172 FTGPQCERDYRTG-----------PCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHP 220
Query: 288 SQQHVGLSRTVR--LHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLT 345
+ R P + + PGL Q V P G L
Sbjct: 221 CEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLN 280
Query: 346 EKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIP-- 403
E +K + + + C G C N+ YFC+ P
Sbjct: 281 EVSQKCEDIDECSTIPGICEGGECTNTVSS----------------------YFCKCPPG 318
Query: 404 ---CLNGGRCIGRDECWCPANSTGKFCHLPIPQPDRE-----PPGRGSRPRALLEAPLKQ 455
+G RCI +C T C +PQ + GR P + +
Sbjct: 319 FYTSPDGTRCIDVRPGYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCP 378
Query: 456 STFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWL 515
T N+L SV P ++ +PP I V V G P +
Sbjct: 379 IRATEDF-NKLCSV-PMVIPGRPEYPPPPLGPIPPVLPVPPGFPPG---------PQIPV 427
Query: 516 PASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLL------GRCYLNTVNGQC-ANPLL 568
P P L+ S EPPR LP L+ GRC + +C N
Sbjct: 428 PRPPVEYLYPSR-------EPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCECNKGF 480
Query: 569 ELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQL--ECPQGYKR-LNLTHCQDINE 625
+L + +C V C P + G +C GY+ L T C+DI+E
Sbjct: 481 QLDLRGECID-------VDECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDE 533
Query: 626 CLTLG-LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISM----LQGLCYRSLGP 680
CL G +C + C+NT GS+ C C G + C S+ L G+C G
Sbjct: 534 CLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIRNMCLNGMCINEDGS 593
Query: 681 GTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLS 740
C ++ C + + C PG IC G
Sbjct: 594 FKCICKPGFQLASDGRYCKDINE--------CETPG------ICMNG------------- 626
Query: 741 MRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQA-----G 795
R G PG A RV DT + + Q G
Sbjct: 627 ----------RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676
Query: 796 QVTTS-VTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATN 854
VT S A P P Q AE Q S+ +T + I+ CA +
Sbjct: 677 AVTKSECCCASTEYAFGEPCQPCPAQNSAEYQ---ALCSSGPGMTSAGSDINECALDP-D 732
Query: 855 VCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC-LRDPCKGKGRCINRVGSYSCFC 913
+C G C NL Y+C+C+ GY++ + C D NEC L G+C N GS+ C C
Sbjct: 733 ICPNGICENLRGTYKCICNSGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTC 792
Query: 914 YPGYTLATSGATQECQDINECEQP----GVCSG--------------------------- 942
G+ T C+DI+ECE GVC
Sbjct: 793 PKGFIYKPDLKT--CEDIDECESSPCINGVCKNSPGSFICECSSESTLDPTKTICIETIK 850
Query: 943 GQCTNTEGSYHCE--------------------------------CDQGYIMVRKGHCQD 970
G C T CE C +GY ++ C+D
Sbjct: 851 GTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICGKGYSRIKGTQCED 910
Query: 971 INECR-HPGTCPDGRCVNSPGSYTCLACEEGYRGQSGS--CVDVN-----------ECLT 1016
I+EC PG C +G CVN+ GS+ C C G + C+D+ EC
Sbjct: 911 IDECEVFPGVCKNGLCVNTRGSFKC-QCPSGMTLDATGRICLDIRLETCFLRYEDEECTL 969
Query: 1017 PGV---------CAHGKCTNLEGSFRCS----------CEQG-----YEVTSDEKGCQDV 1052
P C+ G E C C +G E+T+ + +D+
Sbjct: 970 PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDI 1029
Query: 1053 DECASRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTN 1110
+EC S C G C NT GSF C C++G+ ++ + C D+DEC P +C G C N
Sbjct: 1030 NECKMIPSLCTHGKCRNTIGSFKCR-CDSGFALDSEERNCTDIDECRISPDLCGRGQCVN 1088
Query: 1111 TAGSFSCKDCDGGYRPS-PLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLA 1169
T G F CK CD GY + +C D+DEC+ C GG C NT GSY+C CP G QL+
Sbjct: 1089 TPGDFECK-CDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLS 1147
Query: 1170 -NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPC 1228
N + C D+NEC H P+G C+N G + C C PG+ S C D+DEC+ +
Sbjct: 1148 PNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGG 1207
Query: 1229 VGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLG 1288
C N+EGS+ C C+ GF P+ C DIDECED +C +C N PG YRC+
Sbjct: 1208 CETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECED-NPNICDGGQCTNIPGEYRCL-- 1264
Query: 1289 CQPGFHMAPN-GDCIDIDEC-ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDV 1346
C GF + + C+D++EC N +C S G C+NT GSF C CD G+ C D+
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLS-GTCENTKGSFICHCDMGYSGKKGKTGCTDI 1323
Query: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA 1405
NECE+ CG A+C N GSF C C S GD
Sbjct: 1324 NECEIGAHNCGKHAVCTNTAGSFKCSC------------------------SPGWIGDGI 1359
Query: 1406 PAPTRMDCYSGQ---KGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEI 1462
+C +G HA C + +G C C +G + GD ++ +E +
Sbjct: 1360 KCTDLDECSNGTHMCSQHADCKNTMG----SYRCLCKEGYT-GDGFTCTDLDECSENLNL 1414
Query: 1463 CPSGK--------------GYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPG 1508
C +G+ G++P + D DEC + P +C G C N
Sbjct: 1415 CGNGQCLNAPGGYRCECDMGFVP-----SADGKACEDIDECSL--PNICVFGTCHNLPGL 1467
Query: 1509 YVCLCNPGFHYDASHKKCEDHDECQD-LACENGECVNTEGSFHCFCSPPLTLDLSQQRCM 1567
+ C C G+ D S C D +EC D C +G CVNT GS+ C C P L+ ++ C+
Sbjct: 1468 FRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCV 1527
Query: 1568 NSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPR 1627
++ S + ++DI + D G + CCC G+AW C +CP
Sbjct: 1528 DTRSG-------NCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAV 1580
Query: 1628 SSEVYAQLC 1636
++ Y LC
Sbjct: 1581 NTSEYKILC 1589
Score = 457 bits (1177), Expect = e-128
Identities = 345/1075 (32%), Positives = 434/1075 (40%), Gaps = 233/1075 (21%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRC 902
I+ C GA N C N ++C CSPG+ CTD +EC C C
Sbjct: 1323 INECEIGAHNCGKHAVCTNTAGSFKCSCSPGWI--GDGIKCTDLDECSNGTHMCSQHADC 1380
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYI 961
N +GSY C C GYT G C D++EC E +C GQC N G Y CECD G++
Sbjct: 1381 KNTMGSYRCLCKEGYT----GDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFV 1436
Query: 962 MVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLTPG 1018
G C+DI+EC P C G C N PG + C CE GY G+C DVNECL P
Sbjct: 1437 PSADGKACEDIDECSLPNICVFGTCHNLPGLFRC-ECEIGYELDRSGGNCTDVNECLDPT 1495
Query: 1019 VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDE-----------------CA----- 1056
C G C N GS+ C C +E+ GC D C+
Sbjct: 1496 TCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGV 1555
Query: 1057 --SRASC----------PTGLC--LNT-EGSFACSACENGYWVNEDGTACEDLDECA-FP 1100
S+ASC P +C +NT E C E G+ N ED+DEC P
Sbjct: 1556 GVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGE-GFRPNPITVILEDIDECQELP 1614
Query: 1101 GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQC 1160
G+C G C NT GSF C+ C GY + C+DV+ECE P C G C NTVG+Y C
Sbjct: 1615 GLCQGGKCINTFGSFQCR-CPTGYYLNEDTRVCDDVNECETP-GICGPGTCYNTVGNYTC 1672
Query: 1161 LCPQGFQLANG---------TVC-----EDVNECMGE-------EHCA-----------P 1188
+CP + NG ++C D C GE + C P
Sbjct: 1673 ICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKP 1732
Query: 1189 HGEC-LNSHGSFFCLCA---PGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCL 1243
+C + S F LC PGFV D+DEC C G C+N GSF C
Sbjct: 1733 CEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCE 1792
Query: 1244 CETGFQPSPESGECVDIDECEDYGDPVCG-TWKCENSPGSYRCVLGCQPGFHMAPNGDCI 1302
C GF + + C DIDEC++ PVC +C N+ GSYRC C+PG+ G C
Sbjct: 1793 CPVGFFYNDKLLVCEDIDECQN--GPVCQRNAECINTAGSYRC--DCKPGYRFTSTGQCN 1848
Query: 1303 DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCE 1362
D +EC SHG C +T GSF CLC GF+ + C+D+NECE CG C
Sbjct: 1849 DRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECER--DACGNGTCR 1906
Query: 1363 NVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAP 1422
N GSF C C G + E +G+ C +GQ
Sbjct: 1907 NTIGSFNCRC---------NHGFILSHNNDCIDVDECASGNGNL------CRNGQ----- 1946
Query: 1423 CSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTM 1482
C + +G +C C +G E+ P G+ +
Sbjct: 1947 CINTVG----SFQCQCNEGY------------------EVAPDGRTCV------------ 1972
Query: 1483 YTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC--QDLACENG 1540
D +EC++ P C G C N Y C+C PG Y ++KCED DEC + C G
Sbjct: 1973 --DINECLL-EPRKCAPGTCQNLDGSYRCICPPG--YSLQNEKCEDIDECVEEPEICALG 2027
Query: 1541 ECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLR 1600
C NTEGSF C C +L S +RC D+ M C+ K CS P
Sbjct: 2028 TCSNTEGSFKCLCPEGFSLSSSGRRCQ------------DLRMSYCYAKFEGGKCSSPKS 2075
Query: 1601 GHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPG 1660
+ + CC GE W C LCP E + Q+C YG G
Sbjct: 2076 RNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC-------------------PYGSG 2116
Query: 1661 PDDLHYSIYGP-DGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYV 1719
I GP D A + D NT G P Y+
Sbjct: 2117 ------IIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPF------------GYI 2158
Query: 1720 ASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECD 1779
AG E + +EC + N C NG C V G+ C C EGF+ M C D+NEC
Sbjct: 2159 L------AGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFE-PGPMMTCEDINECA 2211
Query: 1780 DLNGPAVLCVHGYCENTEGSYRCHCSPGYV-------------AEAGPPHCTAKE 1821
+LC C NT GSY C C GYV E G CT K+
Sbjct: 2212 Q---NPLLCAF-RCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQ 2262
Score = 430 bits (1106), Expect = e-120
Identities = 270/810 (33%), Positives = 374/810 (46%), Gaps = 130/810 (16%)
Query: 827 EEQVTPSTDVLVTL---STPG------------IDRCAAGATNVCGPGTCVNLPDGYRCV 871
E+ PSTD TL PG ID C VC G C+N+ +RC
Sbjct: 1734 EQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECRE-IPGVCENGVCINMVGSFRCE 1792
Query: 872 CSPGYQLHPSQAYCTDDNECLRDP-CKGKGRCINRVGSYSCFCYPGYTLATSGATQECQD 930
C G+ + C D +EC P C+ CIN GSY C C PGY ++G +C D
Sbjct: 1793 CPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTG---QCND 1849
Query: 931 INECEQ-PGVCSGGQCTNTEGSYHCECDQGY-IMVRKGHCQDINECRHPGTCPDGRCVNS 988
NEC++ P +CS GQC +T GS++C C G+ + C DINEC C +G C N+
Sbjct: 1850 RNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDA-CGNGTCRNT 1908
Query: 989 PGSYTCLACEEGY-RGQSGSCVDVNECLTPG--VCAHGKCTNLEGSFRCSCEQGYEVTSD 1045
GS+ C C G+ + C+DV+EC + +C +G+C N GSF+C C +GYEV D
Sbjct: 1909 IGSFNC-RCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPD 1967
Query: 1046 EKGCQDVDECASRA-SCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVC 1103
+ C D++EC C G C N +GS+ C C GY + + CED+DEC P +C
Sbjct: 1968 GRTCVDINECLLEPRKCAPGTCQNLDGSYRC-ICPPGYSLQNE--KCEDIDECVEEPEIC 2024
Query: 1104 PSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDV-----------DECEDPQSS------- 1145
G C+NT GSF C C G+ S G C+D+ +C P+S
Sbjct: 2025 ALGTCSNTEGSFKCL-CPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQEC 2083
Query: 1146 --CLGGE--------CKNTVG-SYQCLCPQGFQLANGT--VCEDVNECMGEEHCAPHGEC 1192
L GE C +++ +CP G + G D++EC + C HG+C
Sbjct: 2084 CCALKGEGWGDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCK-HGQC 2142
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252
+N+ GS+ C C G++ A G C D DEC+ +PC G C N G F C CE GF+P P
Sbjct: 2143 INTDGSYRCECPFGYILA--GNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGP 2200
Query: 1253 ESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDT 1311
C DI+EC +P+ ++C N+ GSY C C G+ + + C D DEC
Sbjct: 2201 MM-TCEDINECAQ--NPLLCAFRCVNTYGSYECK--CPVGYVLREDRRMCKDEDECEE-- 2253
Query: 1312 MCGSHGF------CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVE 1365
G H C N G++ C+C G++ P G CVD NEC+ +C C N
Sbjct: 2254 --GKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTR 2311
Query: 1366 GSFLCLCASDL-------EEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQK 1418
GS+ C C E D +EG+C Q+M C G
Sbjct: 2312 GSYTCECNDGFTASPNQDECLDNREGYCFTEVL--QNM----------------CQIGSS 2353
Query: 1419 GHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTF 1478
P T++ECCC G WG C++CP + + F ++CP G+G++
Sbjct: 2354 NRNP--------VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFM-------- 2397
Query: 1479 GQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL--A 1536
T D DEC + +C NG C+N Y C+C G+ D + C D +EC
Sbjct: 2398 --TNGADIDECKVI-HDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKP 2454
Query: 1537 CENGECVNTEGSFHCFCSPPLTLDLSQQRC 1566
C N C NTEGS+ C C L + C
Sbjct: 2455 C-NFICKNTEGSYQCSCPKGYILQEDGRSC 2483
Score = 422 bits (1085), Expect = e-117
Identities = 287/951 (30%), Positives = 411/951 (43%), Gaps = 159/951 (16%)
Query: 939 VCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACE 998
+C G+C T GS CEC++G+ + +G C D++EC C G C+N+ GSYTC C
Sbjct: 459 LCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEK-NPCAGGECINNQGSYTC-QCR 516
Query: 999 EGYRGQ--SGSCVDVNECLTPG-VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
GY+ C D++ECL G +C +G+C N +GSF C C G+ VT D K C+D+DEC
Sbjct: 517 AGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKNCEDMDEC 576
Query: 1056 ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSF 1115
+ R C G+C+N +GSF C C+ G+ + DG C+D++EC PG+C +G C NT GS+
Sbjct: 577 SIRNMCLNGMCINEDGSFKC-ICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSY 635
Query: 1116 SCK---------------------DCDGGYRPS----PLGDSCEDVDECEDPQSSCLGGE 1150
C+ C GGY+ PL + + C G
Sbjct: 636 RCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEP 695
Query: 1151 CK----NTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPG 1206
C+ YQ LC G + + D+NEC + P+G C N G++ C+C G
Sbjct: 696 CQPCPAQNSAEYQALCSSGPGMTSAG--SDINECALDPDICPNGICENLRGTYKCICNSG 753
Query: 1207 FVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECED 1265
+ G +C D++EC C G C NT GSF C C GF P+ C DIDECE
Sbjct: 754 YEVDSTGKNCVDINECVLNSLLCDNGQCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECES 813
Query: 1266 YGDPVCGTWKCENSPGSYRCVLGCQPG----------------FHMAPNGDC-IDIDECA 1308
C C+NSPGS+ C + + +G C I+I+
Sbjct: 814 ---SPCINGVCKNSPGSFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEININGAT 870
Query: 1309 NDTMCGSHGFCDNTDGSFRC----LCDQGFEISPSGWDCVDVNECELMLAVCGAALCENV 1364
+ C S C +C +G+ G C D++ECE+ VC LC N
Sbjct: 871 LKSQCCSSLGAAWGSPCTLCQVDPICGKGYS-RIKGTQCEDIDECEVFPGVCKNGLCVNT 929
Query: 1365 EGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMD-CYSGQKGHAPC 1423
GSF C C S + DA C R++ C+ +
Sbjct: 930 RGSFKCQCPSGMT-LDATGRIC--------------------LDIRLETCFLRYEDEECT 968
Query: 1424 SSVLGRNTTQAECCCTQGASWG-DACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTM 1482
+ GR+ A CCC+ GA+WG + C+ CP ++ E+ E+CP G G+ E T G+
Sbjct: 969 LPIAGRHRMDA-CCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKE--ITNGKPF 1025
Query: 1483 YTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ---DLACEN 1539
+ D +EC + P LC +G+C NT+ + C C+ GF D+ + C D DEC+ DL C
Sbjct: 1026 FKDINECKMI-PSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDL-CGR 1083
Query: 1540 GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKK---VTNDVCS 1596
G+CVNT G F C +C S + + + +D C + VC
Sbjct: 1084 GQCVNTPGDFEC-------------KCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCH 1130
Query: 1597 EPLRGHRTTYTECCCQDGEAWSQQCALCPP-RSSEVYAQLCN-------VARIEAEREAG 1648
+R C C G S + C E+ A LC + + + G
Sbjct: 1131 NTEGSYR-----CECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPG 1185
Query: 1649 VHFRPGYEYGPGPDDLHYSIYGPDGAPFY-NYLGPEDTVPEPAFPNTAGHSADRTPILES 1707
H P + D+ SI F N G + +P F
Sbjct: 1186 YHSTPDRLFCVDIDEC--SIMNGGCETFCTNSEGSYECSCQPGFA--------------- 1228
Query: 1708 PLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDA 1767
L P + + + P N C+ G+C + Y C C++GF
Sbjct: 1229 -LMPDQRSCTDIDECEDNP--------------NICDGGQCTNIPGEYRCLCYDGFMASE 1273
Query: 1768 AHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
CVDVNEC DLN +C+ G CENT+GS+ CHC GY + G CT
Sbjct: 1274 DMKTCVDVNEC-DLN--PNICLSGTCENTKGSFICHCDMGYSGKKGKTGCT 1321
Score = 387 bits (995), Expect = e-107
Identities = 306/1058 (28%), Positives = 451/1058 (42%), Gaps = 185/1058 (17%)
Query: 868 YRCVC--SPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLATSG 923
Y+ +C G++ +P D +EC P C+G G+CIN GS+ C C GY L
Sbjct: 1585 YKILCPGGEGFRPNPITVILEDIDECQELPGLCQG-GKCINTFGSFQCRCPTGYYLNED- 1642
Query: 924 ATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQDI-------NECR 975
T+ C D+NECE PG+C G C NT G+Y C C Y+ V G+ C D+ N
Sbjct: 1643 -TRVCDDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYA 1701
Query: 976 HPGTCPD-----------------GRCVNSPGSYTCLACEEGYRGQSGSC---------- 1008
TC GR N P + + + GS
Sbjct: 1702 DNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYT 1761
Query: 1009 ---VDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTG 1064
VD++EC PGVC +G C N+ GSFRC C G+ C+D+DEC + C
Sbjct: 1762 GLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRN 1821
Query: 1065 L-CLNTEGSFACSACENGYWVNEDGTACEDLDECA-FPGVCPSGVCTNTAGSFSCKDCDG 1122
C+NT GS+ C C+ GY G C D +EC P +C G C +T GSF C C
Sbjct: 1822 AECINTAGSYRCD-CKPGYRFTSTGQ-CNDRNECQEIPNICSHGQCIDTVGSFYCL-CHT 1878
Query: 1123 GYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECM- 1181
G++ + C D++ECE + +C G C+NT+GS+ C C GF L++ C DV+EC
Sbjct: 1879 GFKTNDDQTMCLDINECE--RDACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECAS 1936
Query: 1182 GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTD-PCVGGHCVNTEGSF 1240
G + +G+C+N+ GSF C C G+ A G +C D++EC C G C N +GS+
Sbjct: 1937 GNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQNLDGSY 1996
Query: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD 1300
C+C G+ S ++ +C DIDEC + + +C C N+ GS++C+ C GF ++ +G
Sbjct: 1997 RCICPPGY--SLQNEKCEDIDECVEEPE-ICALGTCSNTEGSFKCL--CPEGFSLSSSGR 2051
Query: 1301 -CIDI-----------DECAN---------DTMCGSHGF-----CD----NTDGSFRCLC 1330
C D+ +C++ + C G C+ D +FR +C
Sbjct: 2052 RCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2111
Query: 1331 DQGFEISPSGWD-CVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPR 1389
G I D VD++EC+ VC C N +GS+ C C P
Sbjct: 2112 PYGSGIIVGPDDSAVDMDECKEP-DVCKHGQCINTDGSYRCEC---------------PF 2155
Query: 1390 G---AGGQSMSEAPTGDHAPAPTRMDCYSGQK-GHAPCSSVLGRNTTQAECCCTQGASWG 1445
G AG + + +C G G+ C +V+G EC C +G G
Sbjct: 2156 GYILAGNECVDTD------------ECSVGNPCGNGTCKNVIGG----FECTCEEGFEPG 2199
Query: 1446 DACDLCPSEDSAEFSEICP--------SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLC 1497
+ A+ +C S + PV + M D DEC G C
Sbjct: 2200 PMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEE-GKHDC 2258
Query: 1498 PNGR--CLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFC 1553
+ C N + Y+C+C PG+ + C D +ECQ CENG C+NT GS+ C C
Sbjct: 2259 TEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCEC 2318
Query: 1554 SPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCS-EPLRGHRTTYTECCCQ 1612
+ T +Q C+++ C+ +V ++C + T +ECCC
Sbjct: 2319 NDGFTASPNQDECLDNREG------------YCFTEVLQNMCQIGSSNRNPVTKSECCCD 2366
Query: 1613 DGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPD 1672
G W C +CP + + + +LC H R G D+
Sbjct: 2367 GGRGWGPHCEICPFQGTVAFKKLC------------PHGRGFMTNGADIDECKVIHDVCR 2414
Query: 1673 GAPFYNYLGPEDTVPEPAF-PNTAGHS-ADRTPILESPLQPSELQPHYVASHP-EPPAGF 1729
N G + + + P+ G S D ++P + + + S+ P G+
Sbjct: 2415 NGECVNDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGY 2474
Query: 1730 EGLQAE--ECGILNGCENGR------CVRVREGYTCDCFEGFQLDAAHMACVDVNEC-DD 1780
LQ + C L+ C + CV G+TC C GF H +C+D NEC D
Sbjct: 2475 I-LQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGF--TQHHTSCIDNNECTSD 2531
Query: 1781 LNGPAVLC-VHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
+N LC G C+NT GS+ C C G+ + C
Sbjct: 2532 IN----LCGSKGICQNTPGSFTCECQRGFSLDQTGSSC 2565
Score = 359 bits (921), Expect = 2e-98
Identities = 285/975 (29%), Positives = 403/975 (41%), Gaps = 170/975 (17%)
Query: 555 YLNTVNGQC-----ANPLLELTTQEDCCGSVGAFWGV-----------TLCAP------- 591
Y T GQC + + + C +VG+F+ + T+C
Sbjct: 1839 YRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERD 1898
Query: 592 -CPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLG--LCKDAECVNTRGSYLCTC 648
C I + C G+ + C D++EC + LC++ +C+NT GS+ C C
Sbjct: 1899 ACGNGTCRNTIGSFNCRCNHGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQC 1958
Query: 649 RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE 708
G + P CV + C PGTC Q + C G + +E
Sbjct: 1959 NEGYEVAPDGRTCVDINECLLEPRKC----APGTC-----QNLDGSYRCICPPGYSLQNE 2009
Query: 709 -CEK----------CPL---PGTE-AFREICPAGHGYTYAS---SDIRLSMRKAEEEELA 750
CE C L TE +F+ +CP G + + D+R+S A+ E
Sbjct: 2010 KCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFE--- 2066
Query: 751 RPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTG 810
G P R + + Q W
Sbjct: 2067 ----------GGKCSSPKSR---------------------NHSKQECCCALKGEGWGDP 2095
Query: 811 NATTPPMPEQGIAEIQEEQVTP-STDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYR 869
P P++ Q+ P + ++V +D +VC G C+N YR
Sbjct: 2096 CELCPTEPDEAF-----RQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYR 2150
Query: 870 CVCSPGYQLHPSQAYCTDDNEC-LRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQEC 928
C C GY L ++ C D +EC + +PC G G C N +G + C C G+ G C
Sbjct: 2151 CECPFGYILAGNE--CVDTDECSVGNPC-GNGTCKNVIGGFECTCEEGF---EPGPMMTC 2204
Query: 929 QDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINEC---RHPGTCPDGR 984
+DINEC Q + +C NT GSY C+C GY++ + C+D +EC +H T
Sbjct: 2205 EDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQME 2264
Query: 985 CVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYE 1041
C N G+Y C+ C GY R CVD NEC T PG+C +G+C N GS+ C C G+
Sbjct: 2265 CKNLIGTYMCI-CGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFT 2323
Query: 1042 VTSDEKGCQDVDE--CASRA---SCPTGLCLNTEGSFACSACENGY-WVNEDGTACE--- 1092
+ ++ C D E C + C G + + C+ G W G CE
Sbjct: 2324 ASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGW----GPHCEICP 2379
Query: 1093 ----------------------DLDEC-AFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL 1129
D+DEC VC +G C N GS+ C C GY P
Sbjct: 2380 FQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHC-ICKTGYTPDIT 2438
Query: 1130 GDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAP 1188
G SC D++EC C CKNT GSYQC CP+G+ L +G C+D++EC ++H
Sbjct: 2439 GTSCVDLNECNQAPKPC-NFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQ 2497
Query: 1189 HGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG--GHCVNTEGSFNCLCET 1246
C+N+ G F C C PGF + TSC D +EC + G G C NT GSF C C+
Sbjct: 2498 F-LCVNTIGGFTCKCPPGF--TQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQR 2554
Query: 1247 GFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF--HMAPNGDCIDI 1304
GF C D+DECE G+ C C+N G YRC C G+ H N C+D
Sbjct: 2555 GFSLDQTGSSCEDVDECE--GNHRC-QHGCQNIIGGYRC--SCPQGYLQHYQWN-QCVDE 2608
Query: 1305 DECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENV 1364
+EC + +CG C NT GS++C+C GF+ C D+NEC A C C N
Sbjct: 2609 NECLSAHICGG-ASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG-CSNT 2666
Query: 1365 EGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTG----DHAPAPTRMDCYSGQKGH 1420
EG +LC C + +GHC G+ E P D++ +P CY +
Sbjct: 2667 EGGYLCGCPPGY--FRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEA--CYECKING 2722
Query: 1421 APCSSVLGRNTTQAE 1435
P R+T + +
Sbjct: 2723 YPKRGRKRRSTNETD 2737
Score = 355 bits (911), Expect = 2e-97
Identities = 270/905 (29%), Positives = 366/905 (40%), Gaps = 180/905 (19%)
Query: 854 NVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG--------------- 898
N+C G C++ + C+C G++ + Q C D NEC RD C
Sbjct: 1858 NICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCN 1917
Query: 899 --------------------------KGRCINRVGSYSCFCYPGYTLATSGATQECQDIN 932
G+CIN VGS+ C C GY +A G T C DIN
Sbjct: 1918 HGFILSHNNDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRT--CVDIN 1975
Query: 933 ECE-QPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINEC-RHPGTCPDGRCVNSPG 990
EC +P C+ G C N +GSY C C GY + + C+DI+EC P C G C N+ G
Sbjct: 1976 ECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNE-KCEDIDECVEEPEICALGTCSNTEG 2034
Query: 991 SYTCLACEEGYRGQSGS--CVDVN-----------ECLTPGVCAHGK---CTNLEG---- 1030
S+ CL C EG+ S C D+ +C +P H K C L+G
Sbjct: 2035 SFKCL-CPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWG 2093
Query: 1031 ------------SFRCSCEQGYEV-TSDEKGCQDVDECASRASCPTGLCLNTEGSFACSA 1077
+FR C G + + D+DEC C G C+NT+GS+ C
Sbjct: 2094 DPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCE- 2152
Query: 1078 CENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVD 1137
C GY + G C D DEC+ C +G C N G F C C+ G+ P P+ +CED++
Sbjct: 2153 CPFGYILA--GNECVDTDECSVGNPCGNGTCKNVIGGFECT-CEEGFEPGPMM-TCEDIN 2208
Query: 1138 ECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDVNECM-GEEHCAPHG-ECLN 1194
EC C C NT GSY+C CP G+ L +C+D +EC G+ C EC N
Sbjct: 2209 ECAQNPLLC-AFRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMECKN 2267
Query: 1195 SHGSFFCLCAPGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLCETGFQPSPE 1253
G++ C+C PG+ G C D +EC T C G C+NT GS+ C C GF SP
Sbjct: 2268 LIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPN 2327
Query: 1254 SGECVDIDECEDYGDPVCGT-----------------------------W--KCENSP-- 1280
DEC D + C T W CE P
Sbjct: 2328 Q------DECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQ 2381
Query: 1281 GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSG 1340
G+ C G NG DIDEC +G C N GS+ C+C G+ +G
Sbjct: 2382 GTVAFKKLCPHGRGFMTNG--ADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITG 2439
Query: 1341 WDCVDVNECELMLAVCGAALCENVEGSFLCLC------------ASDLEEYDAQEGHCR- 1387
CVD+NEC C +C+N EGS+ C C DL+E ++ +C+
Sbjct: 2440 TSCVDLNECNQAPKPCNF-ICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQF 2498
Query: 1388 --PRGAGGQSMSEAP--TGDHAPAPTRMDCYS-----GQKGHAPCSSVLGRNTTQAECCC 1438
GG + P T H +C S G KG C + G T C C
Sbjct: 2499 LCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGI--CQNTPGSFT----CEC 2552
Query: 1439 TQGASWGDACDLCPSEDSAEFSEICPSG-----KGY---IPVEGAWTFGQTMYTDADECV 1490
+G S C D E + C G GY P + D +EC+
Sbjct: 2553 QRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECL 2612
Query: 1491 IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC--QDLACENGECVNTEGS 1548
+C C NT+ Y C+C GF Y+ C+D +EC C G C NTEG
Sbjct: 2613 --SAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYG-CSNTEGG 2669
Query: 1549 FHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSE------PLRGH 1602
+ C C PP + Q C++ P+ + ++ ++ + C E P RG
Sbjct: 2670 YLCGC-PPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECKINGYPKRGR 2728
Query: 1603 RTTYT 1607
+ T
Sbjct: 2729 KRRST 2733
Score = 296 bits (757), Expect = 2e-79
Identities = 256/904 (28%), Positives = 343/904 (37%), Gaps = 237/904 (26%)
Query: 894 DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQP---GVCSGGQCTNTEG 950
D KG C +R Y+ +C PG+ G N+C P C G C+
Sbjct: 51 DALKGPNVCGSR---YNAYCCPGWKTLPGG--------NQCIVPICRHSCGDGFCSRPN- 98
Query: 951 SYHCECDQGYIMVRKG-----HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRG-Q 1004
C C G I G HC C + G+C D C+ C++GY G
Sbjct: 99 --MCTCPSGQIAPSCGSRSIQHCNI--RCMNGGSCSDDHCL----------CQKGYIGTH 144
Query: 1005 SGSCVDVNECLTPGVC-AHGKCTNLEGSFRCSCEQGYEV-----TSDEKGCQDVDECASR 1058
G V + CL G C A +C G CE+ Y + CQ S
Sbjct: 145 CGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQ---LSG 201
Query: 1059 ASCPTGLCLNTEGSF------ACSA----CENGYWVNEDGTACEDLDEC-AFPGVCPSGV 1107
C LC T G C A C G+ N AC+D+DEC A PG+C G
Sbjct: 202 IVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTGACQDVDECQAIPGLCQGGN 261
Query: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
C NT GSF CK C G++ + + CED+DEC C GGEC NTV SY C CP GF
Sbjct: 262 CINTVGSFECK-CPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFY 320
Query: 1168 LA-NGTVCEDVNECMGEEHCA-PHGECLN----SHGSFFCLCAPGFVSAEGGTSCQDVDE 1221
+ +GT C DV G + A +G C N S C C G + G T ++
Sbjct: 321 TSPDGTRCIDVRP--GYCYTALTNGRCSNQLPQSITKMQCCCDAGRCWSPGVTVAPEMCP 378
Query: 1222 CATTDPCVGGHCVNTEGSFNCLCET--------------------------GFQPSPE-- 1253
T+ FN LC GF P P+
Sbjct: 379 IRATE------------DFNKLCSVPMVIPGRPEYPPPPLGPIPPVLPVPPGFPPGPQIP 426
Query: 1254 -----------SGE-----CVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAP 1297
S E V++ + +C +C +PGS RC C GF +
Sbjct: 427 VPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRC--ECNKGFQLDL 484
Query: 1298 NGDCIDIDECANDTMCG----------------------------------------SHG 1317
G+CID+DEC + G ++G
Sbjct: 485 RGECIDVDECEKNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNG 544
Query: 1318 FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC----- 1372
C NTDGSF C+C+ GF ++ G +C D++EC + +C +C N +GSF C+C
Sbjct: 545 RCINTDGSFHCVCNAGFHVTRDGKNCEDMDECSIR-NMCLNGMCINEDGSFKCICKPGFQ 603
Query: 1373 -ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDH-----------------APAPTRMDCY 1414
ASD Y C G G + R CY
Sbjct: 604 LASD-GRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCY 662
Query: 1415 SGQKGHAPCSSVLGRNTTQAECCCTQGA-SWGDACDLCPSEDSAEFSEICPSGKGYIP-- 1471
G K C L T++ECCC ++G+ C CP+++SAE+ +C SG G
Sbjct: 663 GGYK-RGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG 721
Query: 1472 --------------------VEGAW-----------TFGQTMYTDADECVIFGPGLCPNG 1500
+ G + + G+ D +ECV+ LC NG
Sbjct: 722 SDINECALDPDICPNGICENLRGTYKCICNSGYEVDSTGKNC-VDINECVL-NSLLCDNG 779
Query: 1501 RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLD 1560
+C NT +VC C GF Y K CED DEC+ C NG C N+ GSF C CS TLD
Sbjct: 780 QCRNTPGSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNSPGSFICECSSESTLD 839
Query: 1561 LSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQ 1620
++ C+ + T CW+ V + C + G T ++CC G AW
Sbjct: 840 PTKTICIETIKGT------------CWQTVIDGRCEINING-ATLKSQCCSSLGAAWGSP 886
Query: 1621 CALC 1624
C LC
Sbjct: 887 CTLC 890
Score = 185 bits (470), Expect = 3e-46
Identities = 162/578 (28%), Positives = 227/578 (39%), Gaps = 123/578 (21%)
Query: 1289 CQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348
C PG+ P G+ + C + CG GFC + C C G +I+PS +
Sbjct: 67 CCPGWKTLPGGNQCIVPICRHS--CGD-GFCSRPN---MCTCPSG-QIAPS-CGSRSIQH 118
Query: 1349 CELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEG----HCRPRGAGGQSMSEAP--TG 1402
C + G+ ++ CLC Q+G HC GQ + E+ G
Sbjct: 119 CNIRCMNGGSCSDDH------CLC---------QKGYIGTHC------GQPVCESGCLNG 157
Query: 1403 DHAPAPTRMDCYSGQKGH--------APCSSVLGRNTTQAE----------CCCTQGASW 1444
AP R C G G PC +V+ Q + CC T G +W
Sbjct: 158 GRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAW 217
Query: 1445 GDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLN 1504
G C++CP++ P +G+IP D DEC PGLC G C+N
Sbjct: 218 GHPCEMCPAQPH-------PCRRGFIP-----NIRTGACQDVDECQAI-PGLCQGGNCIN 264
Query: 1505 TVPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFCSPPLTLDLS 1562
TV + C C G + +KCED DEC + CE GEC NT S+ C C P
Sbjct: 265 TVGSFECKCPAGHKLNEVSQKCEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPD 324
Query: 1563 QQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCA 1622
RC+ D+ C+ +TN CS L T +CCC G WS
Sbjct: 325 GTRCI------------DVRPGYCYTALTNGRCSNQLP-QSITKMQCCCDAGRCWSPGVT 371
Query: 1623 ----LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYE---YGPGPDDLHYSIYGPDGAP 1675
+CP R++E + +LC+V + + RP Y GP P L P G P
Sbjct: 372 VAPEMCPIRATEDFNKLCSVPMV-------IPGRPEYPPPPLGPIPPVLPV----PPGFP 420
Query: 1676 FYNYLGPEDTVPEPA----FPNTAG------HSADRTPILESPLQPSELQPHYVASHPEP 1725
GP+ VP P +P+ + D ++ Q P + E
Sbjct: 421 ----PGPQIPVPRPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTPGSCRCEC 476
Query: 1726 PAGF------EGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECD 1779
GF E + +EC N C G C+ + YTC C G+Q C D++EC
Sbjct: 477 NKGFQLDLRGECIDVDECE-KNPCAGGECINNQGSYTCQCRAGYQSTLTRTECRDIDECL 535
Query: 1780 DLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
NG +C +G C NT+GS+ C C+ G+ +C
Sbjct: 536 Q-NGR--ICNNGRCINTDGSFHCVCNAGFHVTRDGKNC 570
Score = 107 bits (266), Expect = 1e-22
Identities = 70/223 (31%), Positives = 96/223 (43%), Gaps = 56/223 (25%)
Query: 552 GRCYLNTV----NGQ--CANPLLELTTQEDCCGSVGAFWGVTLCAPCP------------ 593
G CYL+ NG C+N + ++ CC S+G WG T C CP
Sbjct: 1532 GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGKAWG-TPCEMCPAVNTSEYKILCP 1590
Query: 594 ------PRPASPVIEN----------------------GQLECPQGYKRLNLTH-CQDIN 624
P P + ++E+ Q CP GY T C D+N
Sbjct: 1591 GGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVN 1650
Query: 625 ECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRS--LGPGT 682
EC T G+C C NT G+Y C C P M + C + M + LCYR+ T
Sbjct: 1651 ECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNC-----MDMRRSLCYRNYYADNQT 1705
Query: 683 CTLPLAQRITKQICCCS-RVGKAWGSECEKCPLPGTEAFREIC 724
C L +TK++CCCS +G+AW CE+CP+P T+ F +C
Sbjct: 1706 CDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLC 1748
Score = 100 bits (249), Expect = 1e-20
Identities = 50/131 (38%), Positives = 70/131 (53%), Gaps = 13/131 (9%)
Query: 607 ECPQGYKR-LNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
EC GY+ + +C D+NECL C CVNT GSY+C C P L+P+R CV +
Sbjct: 1471 ECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTR 1530
Query: 666 AISMLQGLCYRSL------GPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEA 719
+ G CY + G C+ + ++K CCCS +GKAWG+ CE CP T
Sbjct: 1531 S-----GNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCS-LGKAWGTPCEMCPAVNTSE 1584
Query: 720 FREICPAGHGY 730
++ +CP G G+
Sbjct: 1585 YKILCPGGEGF 1595
Score = 61.2 bits (147), Expect = 9e-09
Identities = 32/84 (38%), Positives = 37/84 (44%), Gaps = 5/84 (5%)
Query: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
EC + C C Y C C GFQ + C D+NEC P C +G C N
Sbjct: 2610 ECLSAHICGGASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAP---CSYG-CSN 2665
Query: 1796 TEGSYRCHCSPGYVAEAGPPHCTA 1819
TEG Y C C PGY G HC +
Sbjct: 2666 TEGGYLCGCPPGYF-RIGQGHCVS 2688
Score = 58.9 bits (141), Expect = 4e-08
Identities = 60/213 (28%), Positives = 84/213 (39%), Gaps = 40/213 (18%)
Query: 552 GRCYLNTVNGQCA------NPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQ 605
G C+ + C NP+ T+ +CC G WG C CP + +
Sbjct: 2337 GYCFTEVLQNMCQIGSSNRNPV----TKSECCCDGGRGWGPH-CEICPFQGTVAF----K 2387
Query: 606 LECPQGYKRLNLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS- 663
CP G R +T+ DI+EC + +C++ ECVN RGSY C C+ G D + + CV
Sbjct: 2388 KLCPHG--RGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYTPDITGTSCVDL 2445
Query: 664 ---DKAISMLQGLCYRSLGPGTCTLP--------------LAQRITKQICCCSRVGKAWG 706
++A +C + G C+ P L + TKQ C G
Sbjct: 2446 NECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRSCKDLDECATKQHNCQFLCVNTIG 2505
Query: 707 SECEKCPLPGTEAFREICPAGHGYTYASSDIRL 739
KCP PG C + T SDI L
Sbjct: 2506 GFTCKCP-PGFTQHHTSCIDNNECT---SDINL 2534
Score = 58.2 bits (139), Expect = 7e-08
Identities = 48/181 (26%), Positives = 74/181 (40%), Gaps = 27/181 (14%)
Query: 554 CYLNTVNGQCANPLLELTTQEDCCGSV-GAFWGVTLCAPCPPRPASPVIENGQLECPQGY 612
CY G+C++P ++++CC ++ G WG C CP P E + CP G
Sbjct: 2061 CYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDP-CELCPTEPD----EAFRQICPYGS 2115
Query: 613 KRL--NLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISM- 669
+ D++EC +CK +C+NT GSY C C G +L + + CV S+
Sbjct: 2116 GIIVGPDDSAVDMDECKEPDVCKHGQCINTDGSYRCECPFGYIL--AGNECVDTDECSVG 2173
Query: 670 ---LQGLCYRSLGPGTCTL-------------PLAQRITKQICCCSRVGKAWGSECEKCP 713
G C +G CT + + + C R +GS KCP
Sbjct: 2174 NPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCP 2233
Query: 714 L 714
+
Sbjct: 2234 V 2234
Score = 56.2 bits (134), Expect = 3e-07
Identities = 28/71 (39%), Positives = 37/71 (52%), Gaps = 6/71 (8%)
Query: 1740 LNGC-ENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEG 1798
+N C G C +TC+C GF LD +C DV+EC+ + C HG C+N G
Sbjct: 2532 INLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDVDECEGNH----RCQHG-CQNIIG 2586
Query: 1799 SYRCHCSPGYV 1809
YRC C GY+
Sbjct: 2587 GYRCSCPQGYL 2597
Score = 52.8 bits (125), Expect = 3e-06
Identities = 48/167 (28%), Positives = 63/167 (37%), Gaps = 47/167 (28%)
Query: 554 CYLNTV--NGQCANPLLELTTQEDCCGS--VGAFWG--------------VTLCAPCPP- 594
CY N N C LL T++ CC S +G W TLC P
Sbjct: 1695 CYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPG 1754
Query: 595 ----------------RPASPVIENG---------QLECPQGY-KRLNLTHCQDINECLT 628
R V ENG + ECP G+ L C+DI+EC
Sbjct: 1755 FVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN 1814
Query: 629 LGLC-KDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLC 674
+C ++AEC+NT GSY C C+PG S +C + +C
Sbjct: 1815 GPVCQRNAECINTAGSYRCDCKPGYRF-TSTGQCNDRNECQEIPNIC 1860
Score = 52.4 bits (124), Expect = 4e-06
Identities = 28/77 (36%), Positives = 38/77 (49%), Gaps = 5/77 (6%)
Query: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
+EC + C++G C + GY C C +G+ CVD NEC A +C C
Sbjct: 2569 DECEGNHRCQHG-CQNIIGGYRCSCPQGYLQHYQWNQCVDENECLS----AHICGGASCH 2623
Query: 1795 NTEGSYRCHCSPGYVAE 1811
NT GSY+C C G+ E
Sbjct: 2624 NTLGSYKCMCPAGFQYE 2640
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/110 (29%), Positives = 45/110 (40%), Gaps = 4/110 (3%)
Query: 552 GRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQG 611
G+C + +C P + +C + G PC VI + C +G
Sbjct: 2140 GQCINTDGSYRCECPFGYILAGNECVDTDECSVG----NPCGNGTCKNVIGGFECTCEEG 2195
Query: 612 YKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
++ + C+DINEC L CVNT GSY C C G +L R C
Sbjct: 2196 FEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMC 2245
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 494 bits (1271), Expect = e-139
Identities = 280/771 (36%), Positives = 389/771 (50%), Gaps = 73/771 (9%)
Query: 887 DDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGG 943
D NEC P C G+C N +GS+ C C G+ L + C DI+EC P +C G
Sbjct: 1073 DINECKAFPGMCT-YGKCRNTIGSFKCRCNSGFALDME--ERNCTDIDECRISPDLCGSG 1129
Query: 944 QCTNTEGSYHCECDQGY---IMVRKGHCQDINEC-RHPGTCPDGRCVNSPGSYTCLACEE 999
C NT GS+ CEC +GY M+ K +C DI+EC R+P C G CVN+ GS+ C C
Sbjct: 1130 ICVNTPGSFECECFEGYESGFMMMK-NCMDIDECERNPLLCRGGTCVNTEGSFQC-DCPL 1187
Query: 1000 GYRGQSG--SCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
G+ CVD+NEC L+ +C +GKC N+ G+++CSC GY+ T D +GC D+DEC
Sbjct: 1188 GHELSPSREDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECM 1247
Query: 1057 -SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGS 1114
C T C N+EGS+ CS C GY + DG +C D+DEC P +C G CTN G
Sbjct: 1248 IMNGGCDTQ-CTNSEGSYECS-CSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGE 1305
Query: 1115 FSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTV- 1173
+ C C G+ S +C DV+EC+ + C+ GEC+NT GS+ C C G+ + GT
Sbjct: 1306 YRCL-CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTG 1364
Query: 1174 CEDVNEC-MGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPC-VG 1230
C DV+EC +G +C H CLN GSF C C G++ G C D+DEC+ T C +
Sbjct: 1365 CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG--NGIKCIDLDECSNGTHQCSIN 1422
Query: 1231 GHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQ 1290
CVNT GS+ C C GF + + C D+DEC + + +C +C N PG+YRC C+
Sbjct: 1423 AQCVNTPGSYRCACSEGF--TGDGFTCSDVDECAENIN-LCENGQCLNVPGAYRCE--CE 1477
Query: 1291 PGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349
GF A + C DIDEC+ +C G C+N G F C+CD G+E+ +G +C D++EC
Sbjct: 1478 MGFTPASDSRSCQDIDECSFQNIC-VFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC 1536
Query: 1350 ELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPT 1409
+ C LC N G + C C D + G C G + P GD
Sbjct: 1537 ADPIN-CVNGLCVNTPGRYECNCPPDFQLNPTGVG-CVDNRVGNCYLKFGPRGD------ 1588
Query: 1410 RMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGY 1469
G C++ +G +++ CCC+ G +WG+ C+ CP +S E+ +CP G+G+
Sbjct: 1589 ---------GSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
Query: 1470 IPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDH 1529
P + D DEC PGLC G C+NT + C C G++ + CED
Sbjct: 1640 RPNPIT-----IILEDIDECQEL-PGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDI 1693
Query: 1530 DEC--QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICW 1587
DEC C G C NT G++ C C P CM D+ C+
Sbjct: 1694 DECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCM------------DMRKSFCY 1741
Query: 1588 KKVTNDVCSEPLRGHRTTYTECCC--QDGEAWSQQCALCPPRSSEVYAQLC 1636
+ C L T CCC G+AW++ C CP + + +C
Sbjct: 1742 RSYNGTTCENEL-PFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTIC 1791
Score = 478 bits (1229), Expect = e-134
Identities = 396/1430 (27%), Positives = 569/1430 (39%), Gaps = 275/1430 (19%)
Query: 552 GRCYLNTVNGQCANPLLELT-TQEDCCGSVGAFWGVTLCAPCPPRPAS------PVIENG 604
G C+ N C L + T+ CC ++G WG C CP +P P I G
Sbjct: 214 GPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHP-CEMCPAQPQPCRRGFIPNIRTG 272
Query: 605 ---------------------------QLECPQGYKRLNLTH-CQDINECLTL-GLCKDA 635
+ CP G+K+ T C+DI+EC + G+C+
Sbjct: 273 ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQI 695
EC NT GSY C C G + SRC+ + G+C+ L G C L R+TK
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRT-----GMCFSGLVNGRCAQELPGRMTKMQ 387
Query: 696 CCCSRVGKAWGSEC--EKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPP 753
CCC G+ WG E CP+ G+E +R +C G L M
Sbjct: 388 CCCEP-GRCWGIGTIPEACPVRGSEEYRRLCMDG-----------LPM------------ 423
Query: 754 REQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNAT 813
G +PG A +P + G P + G T P GN
Sbjct: 424 --------GGIPGSAGSRPGGTGGN-----GFAPSGNGNGYGPGGTGFIPIPG---GNGF 467
Query: 814 TPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCS 873
+P + G+ + + +T+ ID C A N+C G C+ YRC C+
Sbjct: 468 SPGVGGAGVGAGGQGPIITG----LTILNQTIDICKHHA-NLCLNGRCIPTVSSYRCECN 522
Query: 874 PGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINE 933
GY+ + C D +EC +PC G C+N GSY C C+ G+ + Q C DI+E
Sbjct: 523 MGYK-QDANGDCIDVDECTSNPCT-NGDCVNTPGSYYCKCHAGF--QRTPTKQACIDIDE 578
Query: 934 CEQPGV-CSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGS 991
C Q GV C G+C NT+GS+ C C+ G+ + G +C D +EC C +G C+N GS
Sbjct: 579 CIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGS 638
Query: 992 YTCLACEEGY--RGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049
+ C+ C+ G+ C DV+EC TPG+C +G C N EGSFRC C G V D + C
Sbjct: 639 FKCI-CKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVC 697
Query: 1050 QDVDECASRASCPTGL-------------------CLNTEGSFA-----CSA-------- 1077
D R++C G+ C N + F C A
Sbjct: 698 VDTH---MRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHG 754
Query: 1078 -CENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCED 1135
C +G + DG D++ECA P +C +G+C N GS+ C +C+ GY P G +C D
Sbjct: 755 LCSSGVGITVDG---RDINECALDPDICANGICENLRGSYRC-NCNSGYEPDASGRNCID 810
Query: 1136 VDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDVNECMGEEHCAPHGECLN 1194
+DEC + C G C+NT GSY C CP G+ T CED+NEC E + +G C N
Sbjct: 811 IDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC--ESNPCVNGACRN 868
Query: 1195 SHGSFFCLCAPGFVSAEGGTSCQD-------------------------VDECATTDPCV 1229
+ GSF C C+PG + G C D + CAT
Sbjct: 869 NLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAW 928
Query: 1230 GGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGC 1289
G C E + C G + C D++ECE + VC +C NS GS+ C C
Sbjct: 929 GSPCERCE--LDTACPRGL-ARIKGVTCEDVNECEVF-PGVCPNGRCVNSKGSFHC--EC 982
Query: 1290 QPGFHMAPNGD-CIDI-----------DECAN--------DTMCGSHGFCDNTD------ 1323
G + G C+DI DEC + D C + G T+
Sbjct: 983 PEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPK 1042
Query: 1324 ---GSFRCLCDQGFEISPSGWDCV-------DVNECELMLAVCGAALCENVEGSFLCLCA 1373
+ LC +G + G D + D+NEC+ +C C N GSF C C
Sbjct: 1043 PGTKEYETLCPRGAGFANRG-DVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCN 1101
Query: 1374 SDLEEYDAQEGHCRPRGAGGQSMSEAPTG--DHAPAPTRMDCYSG-QKGHAPCSSVLGRN 1430
S D +E +C S +G + P +C+ G + G + + +
Sbjct: 1102 SGF-ALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDID 1160
Query: 1431 TTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV 1490
+ +G + C + + + F CP G P + D +EC
Sbjct: 1161 ECERNPLLCRGGT-------CVNTEGS-FQCDCPLGHELSP-------SREDCVDINECS 1205
Query: 1491 IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL--ACENGECVNTEGS 1548
+ LC NG+C+N + Y C CNPG+ + C D DEC + C+ +C N+EGS
Sbjct: 1206 L-SDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDT-QCTNSEGS 1263
Query: 1549 FHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTE 1608
+ C CS L M S D+ + + + DIC ++ E
Sbjct: 1264 YECSCSEGYAL-------MPDGRSCADIDECENNPDICDGGQCTNIPGE---------YR 1307
Query: 1609 CCCQDGEAWSQQCALC-PPRSSEVYAQLCNVARIEAEREAGV-HFRPGY----------- 1655
C C DG S C ++ + +C E + + + H + GY
Sbjct: 1308 CLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTD 1367
Query: 1656 ----EYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQP 1711
E G D+H S G+ + E + ++ T Q
Sbjct: 1368 VDECEIGAHNCDMHASCLNIPGS--FKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQC 1425
Query: 1712 SELQPHY--VASHPEPPAGFEGLQAEECG-ILNGCENGRCVRVREGYTCDCFEGFQLDAA 1768
Y S GF +EC +N CENG+C+ V Y C+C GF +
Sbjct: 1426 VNTPGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASD 1485
Query: 1769 HMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
+C D++EC N +CV G C N G + C C GY + +CT
Sbjct: 1486 SRSCQDIDECSFQN----ICVFGTCNNLPGMFHCICDDGYELDRTGGNCT 1531
Score = 440 bits (1131), Expect = e-123
Identities = 318/1027 (30%), Positives = 442/1027 (43%), Gaps = 135/1027 (13%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQL-HPSQAYCTDDNECLRDP--CKGKGR 901
ID C + ++CG G CVN P + C C GY+ C D +EC R+P C+G G
Sbjct: 1116 IDECRI-SPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRG-GT 1173
Query: 902 CINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGY 960
C+N GS+ C C G+ L+ S ++C DINEC +C G+C N G+Y C C+ GY
Sbjct: 1174 CVNTEGSFQCDCPLGHELSPS--REDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGY 1231
Query: 961 IMV--RKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLT 1016
R+G C DI+EC D +C NS GSY C +C EGY SC D++EC
Sbjct: 1232 QATPDRQG-CTDIDECMIMNGGCDTQCTNSEGSYEC-SCSEGYALMPDGRSCADIDECEN 1289
Query: 1017 -PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFA 1074
P +C G+CTN+ G +RC C G+ + D K C DV+EC ++ C G C NT+GSF
Sbjct: 1290 NPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFI 1349
Query: 1075 CSACENGYWVNEDGTACEDLDECAFPGV-CPSGV-CTNTAGSFSCKDCDGGYRPSPLGDS 1132
C C+ GY V + T C D+DEC C C N GSF C C G+ + G
Sbjct: 1350 CH-CQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCS-CREGWIGN--GIK 1405
Query: 1133 CEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGE 1191
C D+DEC + C + +C NT GSY+C C +GF +G C DV+EC + +G+
Sbjct: 1406 CIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFT-GDGFTCSDVDECAENINLCENGQ 1464
Query: 1192 CLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS 1251
CLN G++ C C GF A SCQD+DEC+ + CV G C N G F+C+C+ G++
Sbjct: 1465 CLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELD 1524
Query: 1252 PESGECVDIDECEDYGDPV-CGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCID--IDEC 1307
G C DIDEC DP+ C C N+PG Y C C P F + P G C+D + C
Sbjct: 1525 RTGGNCTDIDEC---ADPINCVNGLCVNTPGRYEC--NCPPDFQLNPTGVGCVDNRVGNC 1579
Query: 1308 ----------------------ANDTMCGSHGFC-----------DNTDGSFRCLCDQGF 1334
+ + C S G ++T+ C +GF
Sbjct: 1580 YLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGF 1639
Query: 1335 EISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC------------ASDLEEYDAQ 1382
+P D++EC+ + +C C N GSF C C D++E A
Sbjct: 1640 RPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAH 1699
Query: 1383 EGHCRP----RGAGGQSMSEAP-----TGDHAPAPTRMD-CYSGQKGHAPCSSVLGRNTT 1432
G C P G + P G H R CY G C + L N T
Sbjct: 1700 PGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNG-TTCENELPFNVT 1758
Query: 1433 QAECCCTQ--GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV 1490
+ CCCT G +W C+ CP+ +A+F IC + G+ + D DEC
Sbjct: 1759 KRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGF-----TFDIHTGKAVDIDECK 1813
Query: 1491 IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC---QDLACENGECVNTEG 1547
PG+C NG C+N + + C C GF Y+ CED DEC +L N +C+N+ G
Sbjct: 1814 EI-PGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPG 1872
Query: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607
S+ C C+ L C++ E +P +VCS L
Sbjct: 1873 SYRCECAAGFKLS-PNGACVDRNECLE-IP---------------NVCSHGLCVDLQGSY 1915
Query: 1608 ECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHY- 1666
+C C +G SQ +C N PG+E D L
Sbjct: 1916 QCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDID 1975
Query: 1667 ---SIYGP--DGAPFYNYLGPEDTVPEPAFPNTAGH----SADRTPILESPLQPSELQPH 1717
S +G +N +G + + T + L P Q
Sbjct: 1976 ECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNL 2035
Query: 1718 YVASHPEPPAGFEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHM 1770
+ P G+E +++E C +N C+ G C G+ C C GF L
Sbjct: 2036 EGSFRCICPPGYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGR 2094
Query: 1771 ACVDVNE 1777
C D +
Sbjct: 2095 RCFDTRQ 2101
Score = 439 bits (1128), Expect = e-122
Identities = 287/815 (35%), Positives = 377/815 (46%), Gaps = 109/815 (13%)
Query: 806 AWVTGNATTPPMPEQGIAEIQE--EQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863
AW N P P G A+ + + T + T ID C +C G C+N
Sbjct: 1771 AW---NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKE-IPGICANGVCIN 1826
Query: 864 LPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLAT 921
+RC C G+ + C D +EC C+ CIN GSY C C G+ L+
Sbjct: 1827 QIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSP 1886
Query: 922 SGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINEC-RHPG 978
+GA C D NEC E P VCS G C + +GSY C C G+ + + C D++EC RHP
Sbjct: 1887 NGA---CVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHP- 1942
Query: 979 TCPDGRCVNSPGSYTCLACEEGYR-GQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035
C +G C N+ GSY CL C G+ + C+D++EC + VC +G+C N GSF+C
Sbjct: 1943 -CGNGTCKNTVGSYNCL-CYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCL 2000
Query: 1036 CEQGYEVTSDEKGCQDVDEC-ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDL 1094
C +GYE+T D K C D +EC A SC G C N EGSF C C GY V + C D+
Sbjct: 2001 CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRC-ICPPGYEVKSEN--CIDI 2057
Query: 1095 DEC-AFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCL----GG 1149
+EC P +C G CTNT G F C C G+ S G C D QS C G
Sbjct: 2058 NECDEDPNICLFGSCTNTPGGFQCL-CPPGFVLSDNGRRCFDTR-----QSFCFTNFENG 2111
Query: 1150 ECK-----NTVGSYQC--------------LCPQGFQLANGTVC--------------ED 1176
+C NT + C LCP+ ++A +C ED
Sbjct: 2112 KCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRED 2171
Query: 1177 VNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNT 1236
VNEC+ +G+C+N+ GSF C C G+ G C D DEC+ +PC G C N
Sbjct: 2172 VNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNV 2231
Query: 1237 EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA 1296
GSF C C GF+P P C DI+EC +P+ ++C N+ GSY C C G+ +
Sbjct: 2232 IGSFECNCNEGFEPGPMM-NCEDINECAQ--NPLLCAFRCMNTFGSYECT--CPIGYALR 2286
Query: 1297 PNGD-CIDIDECANDTM-CGSHG-FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353
+ C D+DECA C S G C N G+F C+C G P G CVD NEC
Sbjct: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
Query: 1354 AVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDC 1413
+C C N+ GS+ C C G QS S +G + C
Sbjct: 2347 GICENGRCVNIIGSYRCEC-----------------NEGFQSSS---SGTECLDNRQGLC 2386
Query: 1414 YSGQKGHAPCSSVLGRN-TTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPV 1472
++ + RN T++ECCC G WG C+LCP +A++ +ICP G GY
Sbjct: 2387 FAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGY--- 2443
Query: 1473 EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC 1532
T D DEC + P LC NG+C+NT+ + C C G+ D S C D DEC
Sbjct: 2444 -------TTDGRDIDECKVM-PNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDEC 2495
Query: 1533 -QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRC 1566
Q N C NTEGS+ C C L + C
Sbjct: 2496 SQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTC 2530
Score = 410 bits (1054), Expect = e-114
Identities = 261/835 (31%), Positives = 368/835 (44%), Gaps = 180/835 (21%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
+D CA N+C G C+N+P YRC C G+ C D +EC G C N
Sbjct: 1450 VDECAENI-NLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNN 1508
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQ------ 958
G + C C GY L +G C DI+EC P C G C NT G Y C C
Sbjct: 1509 LPGMFHCICDDGYELDRTGGN--CTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNP 1566
Query: 959 ---GYIMVRKGHCQ-----------------DINECRHPGTCPDGRC----------VNS 988
G + R G+C + R C G+ VNS
Sbjct: 1567 TGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNS 1626
Query: 989 PGSYTCLACEEGYRGQSGSCV--DVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSD 1045
YT EG+R + + D++EC PG+C G C N GSF+C C QGY ++ D
Sbjct: 1627 TEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSED 1686
Query: 1046 EKGCQDVDEC-ASRASCPTGLCLNTEGSFAC--------------------SACENGYWV 1084
+ C+D+DEC A C G C NT G++ C S C Y
Sbjct: 1687 TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSY-- 1744
Query: 1085 NEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE---------- 1134
+GT CE+ E F CT G K C+ P P + +
Sbjct: 1745 --NGTTCEN--ELPFNVTKRMCCCTYNVGKAWNKPCE----PCPTPGTADFKTICGNIPG 1796
Query: 1135 -----------DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDVNECM- 1181
D+DEC++ C G C N +GS++C CP GF + VCED++EC
Sbjct: 1797 FTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSN 1856
Query: 1182 GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT-DPCVGGHCVNTEGSF 1240
G+ C + +C+NS GS+ C CA GF + G +C D +EC + C G CV+ +GS+
Sbjct: 1857 GDNLCQRNADCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSY 1915
Query: 1241 NCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD 1300
C+C GF+ S + C+D+DECE + CG C+N+ GSY C+ C PGF + N D
Sbjct: 1916 QCICHNGFKASQDQTMCMDVDECERHP---CGNGTCKNTVGSYNCL--CYPGFELTHNND 1970
Query: 1301 CIDIDECAN--DTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA 1358
C+DIDEC++ +C +G C N GSF+CLC++G+E++P G +C+D NEC + C
Sbjct: 1971 CLDIDECSSFFGQVC-RNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSP 2029
Query: 1359 ALCENVEGSFLCLCAS----------DLEEYDAQE-----GHCRPRGAGGQSMSE----- 1398
C+N+EGSF C+C D+ E D G C G Q +
Sbjct: 2030 GTCQNLEGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVL 2089
Query: 1399 APTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ--GASWGDACDLCPSEDS 1456
+ G + C++ + + CS NTT+A+CCC++ G WGD C+LCP +D
Sbjct: 2090 SDNGRRCFDTRQSFCFTNFE-NGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDE 2148
Query: 1457 AEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPG 1516
F ++CP G G +P
Sbjct: 2149 VAFQDLCPYGHGTVP--------------------------------------------- 2163
Query: 1517 FHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNS 1569
+ H ED +EC + C NG+C+NT+GSF C C LD + RC+++
Sbjct: 2164 ----SLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
Score = 402 bits (1033), Expect = e-111
Identities = 325/1090 (29%), Positives = 455/1090 (41%), Gaps = 205/1090 (18%)
Query: 848 CAAGAT--NVCGPGTCVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECLRDP--CKGKGRC 902
C+ G N C VN + Y C G++ +P D +EC P C+G G C
Sbjct: 1608 CSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG-GNC 1666
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYI 961
IN GS+ C C GY L+ T+ C+DI+EC PGVC G C NT G+Y C C Y+
Sbjct: 1667 INTFGSFQCECPQGYYLSED--TRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYM 1724
Query: 962 MVRKGH-CQDINEC----RHPGTCPDGR-----------CVNSPGSYTCLACEE------ 999
V GH C D+ + + GT + C + G CE
Sbjct: 1725 QVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGT 1784
Query: 1000 -------------GYRGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSD 1045
+ +G VD++EC PG+CA+G C N GSFRC C G+
Sbjct: 1785 ADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDL 1844
Query: 1046 EKGCQDVDECASRAS-CPTGL-CLNTEGSFACSACENGYWVNEDGTACEDLDECA-FPGV 1102
C+D+DEC++ + C C+N+ GS+ C C G+ ++ +G AC D +EC P V
Sbjct: 1845 LLVCEDIDECSNGDNLCQRNADCINSPGSYRCE-CAAGFKLSPNG-ACVDRNECLEIPNV 1902
Query: 1103 CPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLC 1162
C G+C + GS+ C C G++ S C DVDECE + C G CKNTVGSY CLC
Sbjct: 1903 CSHGLCVDLQGSYQCI-CHNGFKASQDQTMCMDVDECE--RHPCGNGTCKNTVGSYNCLC 1959
Query: 1163 PQGFQLANGTVCEDVNECMGE-EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE 1221
GF+L + C D++EC +G C N GSF CLC G+ G +C D +E
Sbjct: 1960 YPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNE 2019
Query: 1222 C-ATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDP-VCGTWKCENS 1279
C A C G C N EGSF C+C G++ E+ C+DI+EC++ DP +C C N+
Sbjct: 2020 CVALPGSCSPGTCQNLEGSFRCICPPGYEVKSEN--CIDINECDE--DPNICLFGSCTNT 2075
Query: 1280 PGSYRCVLGCQPGFHMAPNGD-CIDIDE------------------------CANDTMCG 1314
PG ++C+ C PGF ++ NG C D + C M G
Sbjct: 2076 PGGFQCL--CPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPG 2133
Query: 1315 SHG-----FCDNTDG-SFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGS 1367
C D +F+ LC G PS D DVNEC +C C N +GS
Sbjct: 2134 EGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGS 2193
Query: 1368 FLCLCASDLE-EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSV 1426
F C C +Y G E G+ G+ C++V
Sbjct: 2194 FRCECPMGYNLDYT---------GVRCVDTDECSIGNPC-------------GNGTCTNV 2231
Query: 1427 LGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP--------SGKGYIPVEGAWTF 1478
+G EC C +G G + + A+ +C S + P+ A
Sbjct: 2232 IG----SFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALRE 2287
Query: 1479 GQTMYTDADECVIFGPGLCPNG--RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLA 1536
Q M D DEC G C + C N + ++C+C PG + C D +EC+
Sbjct: 2288 DQKMCKDLDECAE-GLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
Query: 1537 --CENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDV 1594
CENG CVN GS+ C C+ + +S+S TE L D +C+ +V +
Sbjct: 2347 GICENGRCVNIIGSYRCECN---------EGFQSSSSGTECL---DNRQGLCFAEVLQTI 2394
Query: 1595 CSEPLRGHR-TTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRP 1653
C T +ECCC G W QC LCP + Y ++C
Sbjct: 2395 CQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKIC----------------- 2437
Query: 1654 GYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNT---------AGHSADRTPI 1704
+GPG Y DG + NT G++ D +
Sbjct: 2438 --PHGPG--------YTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487
Query: 1705 LESPLQPSELQP---HYVASHPEP------PAGFEGLQ--AEECGILNGCENGR------ 1747
L P +Y+ + E P G+ LQ + C L+ C+ +
Sbjct: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYV-LQEDGKTCKDLDECQTKQHNCQFL 2546
Query: 1748 CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPG 1807
CV G+TC C GF H AC+D NEC + P++ G C+NT GS+ C C G
Sbjct: 2547 CVNTLGGFTCKCPPGF--TQHHTACIDNNECG--SQPSLCGAKGICQNTPGSFSCECQRG 2602
Query: 1808 YVAEAGPPHC 1817
+ +A +C
Sbjct: 2603 FSLDATGLNC 2612
Score = 400 bits (1028), Expect = e-111
Identities = 276/879 (31%), Positives = 361/879 (41%), Gaps = 166/879 (18%)
Query: 839 TLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLR--DPC 896
T +D C GA N +C+N+P ++C C G+ + C D +EC C
Sbjct: 1362 TTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQC 1419
Query: 897 KGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCE 955
+C+N GSY C C G+T G C D++EC E +C GQC N G+Y CE
Sbjct: 1420 SINAQCVNTPGSYRCACSEGFT----GDGFTCSDVDECAENINLCENGQCLNVPGAYRCE 1475
Query: 956 CDQGYIMVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVN 1012
C+ G+ CQDI+EC C G C N PG + C+ C++GY G+C D++
Sbjct: 1476 CEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCI-CDDGYELDRTGGNCTDID 1534
Query: 1013 ECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQD--VDECASR--------ASCP 1062
EC P C +G C N G + C+C +++ GC D V C + SC
Sbjct: 1535 ECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCN 1594
Query: 1063 TGLCLNTEGSFAC--------SACE-----------------NGYWVNEDGTACEDLDEC 1097
T + + S C + CE G+ N ED+DEC
Sbjct: 1595 TEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDEC 1654
Query: 1098 -AFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVG 1156
PG+C G C NT GSF C +C GY S CED+DEC C G C NT+G
Sbjct: 1655 QELPGLCQGGNCINTFGSFQC-ECPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLG 1713
Query: 1157 SYQCLCPQGFQLA------------------NGTVCE-----DVNECM-------GEEHC 1186
+Y C+CP + NGT CE +V + M G+
Sbjct: 1714 NYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWN 1773
Query: 1187 APHGECLNSHGSFF---CLCAPGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNC 1242
P C + F C PGF D+DEC C G C+N GSF C
Sbjct: 1774 KPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGSFRC 1833
Query: 1243 LCETGFQPSPESGECVDIDECEDYGDPVC-GTWKCENSPGSYRCVLGCQPGFHMAPNGDC 1301
C TGF + C DIDEC + GD +C C NSPGSYRC C GF ++PNG C
Sbjct: 1834 ECPTGFSYNDLLLVCEDIDECSN-GDNLCQRNADCINSPGSYRC--ECAAGFKLSPNGAC 1890
Query: 1302 IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALC 1361
+D +EC SHG C + GS++C+C GF+ S C+DV+ECE CG C
Sbjct: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE--RHPCGNGTC 1948
Query: 1362 ENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHA 1421
+N GS+ CLC E DC +
Sbjct: 1949 KNTVGSYNCLCYPGFE-----------------------------LTHNNDCLDIDE--- 1976
Query: 1422 PCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQT 1481
CSS G+ C G S+ C+ E E+ P GK I
Sbjct: 1977 -CSSFFGQVCRNGRCFNEIG-SFKCLCN--------EGYELTPDGKNCI----------- 2015
Query: 1482 MYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQD--LACEN 1539
D +ECV PG C G C N + C+C PG Y+ + C D +EC + C
Sbjct: 2016 ---DTNECVAL-PGSCSPGTCQNLEGSFRCICPPG--YEVKSENCIDINECDEDPNICLF 2069
Query: 1540 GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPL 1599
G C NT G F C C P L + +RC D C+ N CS P
Sbjct: 2070 GSCTNTPGGFQCLCPPGFVLSDNGRRCF------------DTRQSFCFTNFENGKCSVP- 2116
Query: 1600 RGHRTTYTECCC--QDGEAWSQQCALCPPRSSEVYAQLC 1636
+ TT +CCC GE W C LCP + LC
Sbjct: 2117 KAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
Score = 386 bits (992), Expect = e-107
Identities = 272/856 (31%), Positives = 369/856 (43%), Gaps = 162/856 (18%)
Query: 854 NVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFC 913
NVC G CV+L Y+C+C G++ Q C D +EC R PC G G C N VGSY+C C
Sbjct: 1901 NVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPC-GNGTCKNTVGSYNCLC 1959
Query: 914 YPGYTLATSGATQECQDINECEQ--PGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQD 970
YPG+ L + +C DI+EC VC G+C N GS+ C C++GY + G +C D
Sbjct: 1960 YPGFELTHNN---DCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCID 2016
Query: 971 INEC-RHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC-------------LT 1016
NEC PG+C G C N GS+ C+ C GY +S +C+D+NEC T
Sbjct: 2017 TNECVALPGSCSPGTCQNLEGSFRCI-CPPGYEVKSENCIDINECDEDPNICLFGSCTNT 2075
Query: 1017 PG----VCAHG--------KCTNLEGSF--------RCSCEQGYEVTSDEKGC------- 1049
PG +C G +C + SF +CS + + T + C
Sbjct: 2076 PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEG 2135
Query: 1050 ----------------------------------QDVDECA-SRASCPTGLCLNTEGSFA 1074
+DV+EC S C G C+NT+GSF
Sbjct: 2136 WGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFR 2195
Query: 1075 CSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134
C C GY ++ G C D DEC+ C +G CTN GSF C +C+ G+ P P+ + CE
Sbjct: 2196 CE-CPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFEC-NCNEGFEPGPMMN-CE 2252
Query: 1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGT-VCEDVNECM-GEEHCAPHGE- 1191
D++EC C C NT GSY+C CP G+ L +C+D++EC G C G
Sbjct: 2253 DINECAQNPLLC-AFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMM 2311
Query: 1192 CLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFNCLCETGFQP 1250
C N G+F C+C PG G C D +EC T C G CVN GS+ C C GFQ
Sbjct: 2312 CKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQS 2371
Query: 1251 SPESGECVDIDECEDYGD---PVCGTWK------------CENSPG-SYRCVLGCQPGF- 1293
S EC+D + + + +C C+ G ++C L PG
Sbjct: 2372 SSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTA 2431
Query: 1294 ---HMAPNG-----DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345
+ P+G D DIDEC ++G C NT GSFRC C G+ SG C+D
Sbjct: 2432 QYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGTSCID 2491
Query: 1346 VNECELMLAVCGAALCENVEGSFLCLC------------ASDLEEYDAQEGHCR---PRG 1390
++EC C +C+N EGS+ C C DL+E ++ +C+
Sbjct: 2492 LDECSQSPKPCNY-ICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNT 2550
Query: 1391 AGGQSMSEAP--TGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDAC 1448
GG + P T H +C S Q + C C +G S DA
Sbjct: 2551 LGGFTCKCPPGFTQHHTACIDNNECGS-QPSLCGAKGICQNTPGSFSCECQRGFSL-DAT 2608
Query: 1449 DL-CPSEDSAEFSEICPSG-------------KGYIPVEGAWTFGQTMYTDADECVIFGP 1494
L C D + + C G +GYI + D +EC P
Sbjct: 2609 GLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQ-----HYQWNQCVDENECS--NP 2661
Query: 1495 GLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL--ACENGECVNTEGSFHCF 1552
C + C NT+ Y C C GF +D C D +EC C G C NTEG + C
Sbjct: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG-CSNTEGGYLCG 2720
Query: 1553 CSPPLTLDLSQQRCMN 1568
C PP + Q C++
Sbjct: 2721 C-PPGYYRVGQGHCVS 2735
Score = 365 bits (937), Expect = e-100
Identities = 277/898 (30%), Positives = 375/898 (41%), Gaps = 150/898 (16%)
Query: 591 PCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTL--GLCKDAECVNTRGSYLCTC 648
PC + + C G++ + C DI+EC + +C++ C N GS+ C C
Sbjct: 1942 PCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLC 2001
Query: 649 RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGS- 707
G L P C+ L G C PGTC Q + C G S
Sbjct: 2002 NEGYELTPDGKNCIDTNECVALPGSC----SPGTC-----QNLEGSFRCICPPGYEVKSE 2052
Query: 708 ------ECEKCP----------LPGTEAFREICPAG-----HGYTYASSDIRLSMRKAEE 746
EC++ P PG F+ +CP G +G + E
Sbjct: 2053 NCIDINECDEDPNICLFGSCTNTPG--GFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFEN 2110
Query: 747 EELARPPREQGQRSS---GALPGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTH 803
+ + P ++ +PG + W + + K D A Q
Sbjct: 2111 GKCSVPKAFNTTKAKCCCSKMPG-----------EGWGDPCELCPKDDEVAFQDLCPY-- 2157
Query: 804 APAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863
G+ T P + + DV L +PGI C G C+N
Sbjct: 2158 ------GHGTVPSLHD------------TREDVNECLESPGI----------CSNGQCIN 2189
Query: 864 LPDGYRCVCSPGYQLHPSQAYCTDDNEC-LRDPCKGKGRCINRVGSYSCFCYPGYTLATS 922
+RC C GY L + C D +EC + +PC G G C N +GS+ C C G+
Sbjct: 2190 TDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPC-GNGTCTNVIGSFECNCNEGF---EP 2245
Query: 923 GATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINECR---HPG 978
G C+DINEC Q + +C NT GSY C C GY + + C+D++EC H
Sbjct: 2246 GPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAEGLHDC 2305
Query: 979 TCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCS 1035
C N G++ C+ C G R CVD NEC T PG+C +G+C N+ GS+RC
Sbjct: 2306 ESRGMMCKNLIGTFMCI-CPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCE 2364
Query: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLC--------LNTEGSFACSA---------- 1077
C +G++ +S C D + A +C L T+ C
Sbjct: 2365 CNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCEL 2424
Query: 1078 ------------CENGYWVNEDGTACEDLDEC-AFPGVCPSGVCTNTAGSFSCKDCDGGY 1124
C +G DG D+DEC P +C +G C NT GSF C C GY
Sbjct: 2425 CPLPGTAQYKKICPHGPGYTTDG---RDIDECKVMPNLCTNGQCINTMGSFRC-FCKVGY 2480
Query: 1125 RPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGE 1183
G SC D+DEC C CKNT GSYQC CP+G+ L +G C+D++EC +
Sbjct: 2481 TTDISGTSCIDLDECSQSPKPC-NYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTK 2539
Query: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG--GHCVNTEGSFN 1241
+H C+N+ G F C C PGF + T+C D +EC + G G C NT GSF+
Sbjct: 2540 QHNCQF-LCVNTLGGFTCKCPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS 2596
Query: 1242 CLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF--HMAPNG 1299
C C+ GF C D+DEC+ G+ C C+N G YRC GC G+ H N
Sbjct: 2597 CECQRGFSLDATGLNCEDVDECD--GNHRC-QHGCQNILGGYRC--GCPQGYIQHYQWN- 2650
Query: 1300 DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAA 1359
C+D +EC+N CGS C NT GS++C C GF C DVNEC C
Sbjct: 2651 QCVDENECSNPNACGS-ASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYG 2709
Query: 1360 LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAG---GQSMSEAPTGDHAPAPTRMDCY 1414
C N EG +LC C Y +GHC G G GQ +S D A + CY
Sbjct: 2710 -CSNTEGGYLCGCPPGY--YRVGQGHC-VSGMGFNKGQYLSLDTEVDEENALSPEACY 2763
Score = 347 bits (891), Expect = 5e-95
Identities = 249/797 (31%), Positives = 341/797 (42%), Gaps = 96/797 (12%)
Query: 552 GRCYLNTVNGQC-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQ 610
GRC+ + +C N ELT C V L C P + + + CP
Sbjct: 1988 GRCFNEIGSFKCLCNEGYELTPDGKNCIDTNEC--VALPGSCSPGTCQNLEGSFRCICPP 2045
Query: 611 GYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISM 669
GY+ + +C DINEC +C C NT G + C C PG +L + RC +
Sbjct: 2046 GYE-VKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTR---- 2100
Query: 670 LQGLCYRSLGPGTCTLPLAQRITKQICCCSRV-GKAWGSECEKCPLPGTEAFREICPAGH 728
Q C+ + G C++P A TK CCCS++ G+ WG CE CP AF+++CP GH
Sbjct: 2101 -QSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGH 2159
Query: 729 GYTYASSDIRLSMRKAEEE----ELARPPREQGQ-RSSGALPGPAERQPLRVVTDTWLEA 783
G + D R + + E + G R + + +R V
Sbjct: 2160 GTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSI 2219
Query: 784 GTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP 843
G + G T + N P P +I E P ++T
Sbjct: 2220 G-------NPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTF 2272
Query: 844 GIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLR--DPCKGKG- 900
G C TC P GY L Q C D +EC C+ +G
Sbjct: 2273 GSYEC-----------TC---PIGY--------ALREDQKMCKDLDECAEGLHDCESRGM 2310
Query: 901 RCINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQG 959
C N +G++ C C PG G + C D NEC +PG+C G+C N GSY CEC++G
Sbjct: 2311 MCKNLIGTFMCICPPGMARRPDG--EGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368
Query: 960 YIMVRKGH------------------CQDINECRHPGT----CPDG------RCVNSPGS 991
+ G CQ + R+ T C DG +C P
Sbjct: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
Query: 992 YTC---LACEEGYRGQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEK 1047
T C G G + D++EC + P +C +G+C N GSFRC C+ GY
Sbjct: 2429 GTAQYKKICPHG-PGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDISGT 2487
Query: 1048 GCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV 1107
C D+DEC+ +C NTEGS+ CS C GY + EDG C+DLDEC +
Sbjct: 2488 SCIDLDECSQSPKPCNYICKNTEGSYQCS-CPRGYVLQEDGKTCKDLDECQTKQHNCQFL 2546
Query: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGF 1166
C NT G F+CK C G+ + +C D +EC S C G C+NT GS+ C C +GF
Sbjct: 2547 CVNTLGGFTCK-CPPGF--TQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
Query: 1167 QL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATT 1225
L A G CEDV+EC G C HG C N G + C C G++ C D +EC+
Sbjct: 2604 SLDATGLNCEDVDECDGNHRC-QHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNP 2661
Query: 1226 DPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRC 1285
+ C C NT GS+ C C +GF S C D++EC +P + C N+ G Y C
Sbjct: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLC 2719
Query: 1286 VLGCQPGFHMAPNGDCI 1302
GC PG++ G C+
Sbjct: 2720 --GCPPGYYRVGQGHCV 2734
Score = 281 bits (718), Expect = 5e-75
Identities = 257/905 (28%), Positives = 341/905 (37%), Gaps = 222/905 (24%)
Query: 893 RDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQP---GVCSGGQCTNTE 949
+D +G C +R SY C PG+ G N+C P C G C+
Sbjct: 80 QDVLRGPNVCGSRFHSYCC---PGWKTLPGG--------NQCIVPICRNSCGDGFCSRPN 128
Query: 950 GSYHCECDQGYIMVRKGHC---QDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQ-S 1005
C C G I G Q C + GTC D C C++GY G
Sbjct: 129 ---MCTCSSGQISSTCGSKSIQQCSVRCMNGGTCADDHC----------QCQKGYIGTYC 175
Query: 1006 GSCVDVNECLTPGVC-AHGKCTNLEGSFRCSCEQGYEVTS-----DEKGCQDVDECASRA 1059
G V N C G C +C + G CE+ Y + + CQ +
Sbjct: 176 GQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQ---LTGI 232
Query: 1060 SCPTGLCLNTEGSF------ACSA----CENGYWVNEDGTACEDLDEC-AFPGVCPSGVC 1108
C LC T G C A C G+ N AC+D+DEC A PG+C G C
Sbjct: 233 VCTKTLCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNC 292
Query: 1109 TNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL 1168
NT GSF C+ C G++ S CED+DEC C GEC NTVGSY C+CP+G+
Sbjct: 293 INTVGSFECR-CPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVT 351
Query: 1169 A-NGTVCEDVNECMGEEHCAPHGECLNS----HGSFFCLCAPGFV--------------S 1209
+ +G+ C D M +G C C C PG S
Sbjct: 352 STDGSRCIDQRTGMCFSGLV-NGRCAQELPGRMTKMQCCCEPGRCWGIGTIPEACPVRGS 410
Query: 1210 AEGGTSCQD------VDECATTDP-CVGGHCVNTEGSFNCLCE--TGFQPSP-------- 1252
E C D + A + P GG+ G+ N TGF P P
Sbjct: 411 EEYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGFSPG 470
Query: 1253 ---------ESGECV--------DIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM 1295
G + ID C+ + + +C +C + SYRC C G+
Sbjct: 471 VGGAGVGAGGQGPIITGLTILNQTIDICKHHAN-LCLNGRCIPTVSSYRC--ECNMGYKQ 527
Query: 1296 APNGDCIDIDECA-----------------------------------------NDTMCG 1314
NGDCID+DEC N +C
Sbjct: 528 DANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLC- 586
Query: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC-- 1372
+G C NTDGSF+C+C+ GFE++ G +CVD +EC +C +C N +GSF C+C
Sbjct: 587 KNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDEC-TTTNMCLNGMCINEDGSFKCICKP 645
Query: 1373 ----------ASDLEEYD----AQEGHCRPRGAGGQSMSEAPTG--------DHAPAPTR 1410
+D++E GHC + G + P G R
Sbjct: 646 GFVLAPNGRYCTDVDECQTPGICMNGHC--INSEGSFRCDCPPGLAVGMDGRVCVDTHMR 703
Query: 1411 MDCYSGQKGHAPCSSVLGRNTTQAECCCTQ-GASWGDACDLCPSEDSAEFSEICPSGKGY 1469
CY G K C T++ECCC +G+ C CP+++SAEF +C SG G
Sbjct: 704 STCYGGIK-KGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG- 761
Query: 1470 IPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDH 1529
I V+G D +EC + P +C NG C N Y C CN G+ DAS + C D
Sbjct: 762 ITVDG---------RDINECAL-DPDICANGICENLRGSYRCNCNSGYEPDASGRNCIDI 811
Query: 1530 DEC--QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMN------------------- 1568
DEC L C+NG C NT GS+ C C P + C +
Sbjct: 812 DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLG 871
Query: 1569 ---------STSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQ 1619
S S+ L D CW + + C + G T +ECC G AW
Sbjct: 872 SFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING-ATLKSECCATLGAAWGS 930
Query: 1620 QCALC 1624
C C
Sbjct: 931 PCERC 935
Score = 189 bits (481), Expect = 2e-47
Identities = 157/560 (28%), Positives = 217/560 (38%), Gaps = 72/560 (12%)
Query: 1289 CQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348
C PG+ P G+ + C N CG GFC + C C G S G + +
Sbjct: 97 CCPGWKTLPGGNQCIVPICRNS--CGD-GFCSRPN---MCTCSSGQISSTCG--SKSIQQ 148
Query: 1349 CELML---AVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA 1405
C + C C+ +G C + E Q G R G + TG
Sbjct: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGG-RCIGPNRCACVYGFTGPQC 207
Query: 1406 PAPTRMDCYSGQKGHAPCSSVL-GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
R Q + C L G T+ CC T G +WG C++CP++ P
Sbjct: 208 ERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ-------P 260
Query: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524
+G+IP D DEC PG+C G C+NTV + C C G + +
Sbjct: 261 CRRGFIP-----NIRTGACQDVDECQAI-PGICQGGNCINTVGSFECRCPAGHKQSETTQ 314
Query: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIH 1582
KCED DEC + CE GEC NT GS+ C C RC+ D
Sbjct: 315 KCEDIDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRCI------------DQR 362
Query: 1583 MDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQC--ALCPPRSSEVYAQLCNVAR 1640
+C+ + N C++ L G R T +CCC+ G W CP R SE Y +LC
Sbjct: 363 TGMCFSGLVNGRCAQELPG-RMTKMQCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGL 421
Query: 1641 IEAEREAGVHFRPGYEYGPG-PDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA 1699
RPG G G + + YGP G F G P +
Sbjct: 422 PMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPGGTGFIPIPGGNGF--SPGVGGAGVGAG 479
Query: 1700 DRTPILESPL---QPSELQPHY------------VASHP-------EPPAGFEGLQAEEC 1737
+ PI+ Q ++ H+ V+S+ + A + + +EC
Sbjct: 480 GQGPIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDEC 539
Query: 1738 GILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTE 1797
N C NG CV Y C C GFQ AC+D++EC NG VLC +G C NT+
Sbjct: 540 -TSNPCTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQ-NG--VLCKNGRCVNTD 595
Query: 1798 GSYRCHCSPGYVAEAGPPHC 1817
GS++C C+ G+ +C
Sbjct: 596 GSFQCICNAGFELTTDGKNC 615
Score = 127 bits (319), Expect = 1e-28
Identities = 67/184 (36%), Positives = 98/184 (53%), Gaps = 22/184 (11%)
Query: 550 LLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLE-- 607
L G C+LN + +C + T + +CC ++GA WG +PC E +L+
Sbjct: 894 LKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWG----SPC---------ERCELDTA 940
Query: 608 CPQGYKRLNLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKA 666
CP+G R+ C+D+NEC G+C + CVN++GS+ C C GL LD + C+
Sbjct: 941 CPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLD--- 997
Query: 667 ISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPA 726
I M Q CY C P+ + CCC+ VG AWG+ECE+CP PGT+ + +CP
Sbjct: 998 IRMEQ--CYLKWDEDECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLCPR 1054
Query: 727 GHGY 730
G G+
Sbjct: 1055 GAGF 1058
Score = 108 bits (269), Expect = 6e-23
Identities = 72/230 (31%), Positives = 95/230 (41%), Gaps = 54/230 (23%)
Query: 551 LGRCYLN-----TVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPP----------- 594
+G CYL + C + ++ CC S+G WG C CPP
Sbjct: 1576 VGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWG-NPCETCPPVNSTEYYTLCP 1634
Query: 595 -------RPASPVIEN----------------------GQLECPQGYKRLNLTH-CQDIN 624
P + ++E+ Q ECPQGY T C+DI+
Sbjct: 1635 GGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDID 1694
Query: 625 ECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTC 683
EC G+C C NT G+Y C C P M C+ M + CYRS TC
Sbjct: 1695 ECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD-----MRKSFCYRSYNGTTC 1749
Query: 684 TLPLAQRITKQICCCS-RVGKAWGSECEKCPLPGTEAFREICPAGHGYTY 732
L +TK++CCC+ VGKAW CE CP PGT F+ IC G+T+
Sbjct: 1750 ENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTF 1799
Score = 90.1 bits (222), Expect = 2e-17
Identities = 47/130 (36%), Positives = 67/130 (51%), Gaps = 14/130 (10%)
Query: 608 CPQGYKRLNLT--HCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
C GY+ L+ T +C DI+EC C + CVNT G Y C C P L+P+ CV ++
Sbjct: 1517 CDDGYE-LDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR 1575
Query: 666 AISMLQGLCYRSLGPG-----TCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF 720
G CY GP +C + +++ CCCS +GKAWG+ CE CP + +
Sbjct: 1576 V-----GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCS-LGKAWGNPCETCPPVNSTEY 1629
Query: 721 REICPAGHGY 730
+CP G G+
Sbjct: 1630 YTLCPGGEGF 1639
Score = 69.3 bits (168), Expect = 3e-11
Identities = 35/84 (41%), Positives = 38/84 (45%), Gaps = 5/84 (5%)
Query: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
EC N C + C Y C C GF D AC DVNEC P C +G C N
Sbjct: 2657 ECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNP---CNYG-CSN 2712
Query: 1796 TEGSYRCHCSPGYVAEAGPPHCTA 1819
TEG Y C C PGY G HC +
Sbjct: 2713 TEGGYLCGCPPGYY-RVGQGHCVS 2735
Score = 66.2 bits (160), Expect = 3e-10
Identities = 44/116 (37%), Positives = 51/116 (43%), Gaps = 24/116 (20%)
Query: 114 RVQPPAQTRRSTPLGQQQP--APRTRAAPALPRLGTPQRSGAAPPTPPRGR-----LTGR 166
R QPP Q RS G + AP R GAA + R R L G
Sbjct: 39 RPQPPPQQVRSATAGSEGGFLAPEYR------------EEGAAVASRVRRRGQQDVLRGP 86
Query: 167 NVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARC 218
NVCG + CCPGW T N CI P+C C + G CSRP +C C SG + C
Sbjct: 87 NVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGD-GFCSRPNMCTCSSGQISSTC 141
Score = 62.0 bits (149), Expect = 5e-09
Identities = 27/74 (36%), Positives = 39/74 (52%), Gaps = 4/74 (5%)
Query: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
+EC N C G C + + C C +G++LD C D++EC D + CV+G C
Sbjct: 1493 DECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECAD----PINCVNGLCV 1548
Query: 1795 NTEGSYRCHCSPGY 1808
NT G Y C+C P +
Sbjct: 1549 NTPGRYECNCPPDF 1562
Score = 59.7 bits (143), Expect = 3e-08
Identities = 31/79 (39%), Positives = 40/79 (50%), Gaps = 10/79 (12%)
Query: 1731 GLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790
G Q CG C+N ++C+C GF LDA + C DV+ECD + C H
Sbjct: 2576 GSQPSLCGAKGICQN-----TPGSFSCECQRGFSLDATGLNCEDVDECDGNH----RCQH 2626
Query: 1791 GYCENTEGSYRCHCSPGYV 1809
G C+N G YRC C GY+
Sbjct: 2627 G-CQNILGGYRCGCPQGYI 2644
Score = 53.5 bits (127), Expect = 2e-06
Identities = 27/74 (36%), Positives = 37/74 (50%), Gaps = 5/74 (6%)
Query: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
+EC + C++G C + GY C C +G+ CVD NEC + N C C
Sbjct: 2616 DECDGNHRCQHG-CQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNA----CGSASCY 2670
Query: 1795 NTEGSYRCHCSPGY 1808
NT GSY+C C G+
Sbjct: 2671 NTLGSYKCACPSGF 2684
Score = 50.4 bits (119), Expect = 2e-05
Identities = 53/210 (25%), Positives = 76/210 (36%), Gaps = 57/210 (27%)
Query: 554 CYLNTVNGQCANPLLELTTQEDCCGS--VGAFWGVTLCAPCPP----------------- 594
CY + C N L T+ CC + VG W C PCP
Sbjct: 1740 CYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKP-CEPCPTPGTADFKTICGNIPGFT 1798
Query: 595 --------------RPASPVIENG---------QLECPQGYKRLNLTH-CQDINECLTL- 629
+ + NG + ECP G+ +L C+DI+EC
Sbjct: 1799 FDIHTGKAVDIDECKEIPGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGD 1858
Query: 630 GLC-KDAECVNTRGSYLCTCRPGLMLDPS-----RSRCVSDKAISMLQGLCYRSLGPGTC 683
LC ++A+C+N+ GSY C C G L P+ R+ C+ + GLC G C
Sbjct: 1859 NLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCS-HGLCVDLQGSYQC 1917
Query: 684 TLPLAQRITKQICCCSRVGKAWGSECEKCP 713
+ ++ C V ECE+ P
Sbjct: 1918 ICHNGFKASQDQTMCMDV-----DECERHP 1942
Score = 48.5 bits (114), Expect = 6e-05
Identities = 54/202 (26%), Positives = 72/202 (35%), Gaps = 46/202 (22%)
Query: 254 EGTLARAQPPAPQSPPAPQSPP-------AGTLSGLSQTHPSQQHVGLSRTVR------- 299
+GT + QPP P+ PP PQ PP AG+ G ++ ++ VR
Sbjct: 24 QGTAGQPQPPPPK-PPRPQPPPQQVRSATAGSEGGFLAPEYREEGAAVASRVRRRGQQDV 82
Query: 300 LHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPS--------------SPWGLNLT 345
L S+ S P L G Q VP+ S S ++ T
Sbjct: 83 LRGPNVCGSRFHSYCCPGWKTLP--GGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISST 140
Query: 346 EKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCL 405
K I+ + TCA HC C++G T Q C+ C
Sbjct: 141 CGSKSIQQCSVRCMNGGTCADDHC--QCQKGYIGTYCGQP-------------VCENGCQ 185
Query: 406 NGGRCIGRDECWCPANSTGKFC 427
NGGRCIG + C C TG C
Sbjct: 186 NGGRCIGPNRCACVYGFTGPQC 207
Score = 47.0 bits (110), Expect = 2e-04
Identities = 24/60 (40%), Positives = 27/60 (45%), Gaps = 9/60 (15%)
Query: 169 CGGQCCPGWTTANSTNHCIK---------PVCEPPCQNRGSCSRPQLCVCRSGFRGARCE 219
C +C G T A+ C K PVCE CQN G C P C C GF G +CE
Sbjct: 149 CSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCE 208
Score = 46.2 bits (108), Expect = 3e-04
Identities = 33/134 (24%), Positives = 48/134 (35%), Gaps = 19/134 (14%)
Query: 595 RPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTC------ 648
RP +GQ+ G K + Q C+ G C D C +G C
Sbjct: 126 RPNMCTCSSGQISSTCGSKSIQ----QCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCE 181
Query: 649 ----RPGLMLDPSRSRCVSDKAISMLQ-----GLCYRSLGPGTCTLPLAQRITKQICCCS 699
G + P+R CV + G C+ + C L + + CC+
Sbjct: 182 NGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCA 241
Query: 700 RVGKAWGSECEKCP 713
+G+AWG CE CP
Sbjct: 242 TIGRAWGHPCEMCP 255
Score = 37.0 bits (84), Expect = 0.18
Identities = 20/52 (38%), Positives = 24/52 (46%), Gaps = 2/52 (3%)
Query: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVD--VNECDDLNGP 1784
+EC C NG CV Y C+C FQL+ + CVD V C GP
Sbjct: 1534 DECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGP 1585
Score = 35.0 bits (79), Expect = 0.67
Identities = 25/97 (25%), Positives = 33/97 (34%), Gaps = 2/97 (2%)
Query: 1726 PAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNG-- 1783
P G +EC C NG C+ + CDC G + CVD + G
Sbjct: 651 PNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGI 710
Query: 1784 PAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAK 1820
+CV + S C +P Y C AK
Sbjct: 711 KKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAK 747
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 482 bits (1241), Expect = e-135
Identities = 397/1417 (28%), Positives = 545/1417 (38%), Gaps = 275/1417 (19%)
Query: 607 ECPQGYK-RLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
+CP G++ T C+DI+EC L+ GLC +CVN G++ C+C G P R CV
Sbjct: 1097 QCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDI 1156
Query: 665 KAISMLQG----LCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAF 720
+ G C + G C+ + C+ V ECE+ P +
Sbjct: 1157 NECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACADV-----DECEENPRVCDQGH 1211
Query: 721 REICPAGH------GYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLR 774
P GH G+ A+ D+R + + +E P L G E
Sbjct: 1212 CTNMPGGHRCLCYDGFM-ATPDMRTCV---DVDECDLNPHI-------CLHGDCENTKGS 1260
Query: 775 VVTDTWLEAGTIPDKGDSQAGQVTTSV-------THA--------------PAWVTGNAT 813
V L G + KG + V +HA P WV
Sbjct: 1261 FVCHCQL--GYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFE 1318
Query: 814 TPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCA------------------AGATNV 855
+ E QE + +P D L + PG RC A ++
Sbjct: 1319 CHDLDE---CVSQEHRCSPRGDCL---NVPGSYRCTCRQGFAGDGFFCEDRDECAENVDL 1372
Query: 856 CGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYP 915
C G C+N P GYRC C G+ C D +EC + G C N G + C C
Sbjct: 1373 CDNGQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGNLCAFGSCENLPGMFRCICNG 1432
Query: 916 GYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQ---------GYIMVRKG 966
GY L G C DINEC P C G C NT GSY C C Q G + R G
Sbjct: 1433 GYELDRGGGN--CTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAG 1490
Query: 967 HCQ-----------------DINECRHPGTCPDGRCVNSPGSYTCLACEEGYR----GQS 1005
+C + R C GR +P +A YR G
Sbjct: 1491 NCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGE 1550
Query: 1006 GS--------CVDVNECLT-PGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
G D++EC PG+C G C N GSF+C C GY ++ + C+D+DEC+
Sbjct: 1551 GFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECS 1610
Query: 1057 SRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA----FPGVCPSGVCTNT 1111
+ + C G C NT G++ C C Y G C D+ + + G C + + N
Sbjct: 1611 THSGICGPGTCYNTLGNYTC-VCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNV 1669
Query: 1112 AGSFSCKDCDGGYR--------PSPLGDSCE--------------------DVDECEDPQ 1143
C + G P+P+ + D+DEC +
Sbjct: 1670 TRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIP 1729
Query: 1144 SSCLGGECKNTVGSYQCLCPQGFQLANGTV-CEDVNECMGEEH-CAPHGECLNSHGSFFC 1201
+ C G C N +GS++C CP GF + + CEDV+EC E C + +C+N GS+ C
Sbjct: 1730 AICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRC 1789
Query: 1202 LCAPGFVSAEGGTSCQDVDECATT-DPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260
C G+ + GG +C +EC + C G C++TEGS+ CLC GFQ S + C+DI
Sbjct: 1790 KCTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDI 1848
Query: 1261 DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGS---HG 1317
DEC+ CG C+N GSY C+ C PGF + NGDC+D DEC T+ G G
Sbjct: 1849 DECDRQP---CGNGTCKNIIGSYNCL--CFPGFVVTHNGDCVDFDECT--TLVGQVCRFG 1901
Query: 1318 FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLE 1377
C NT GSF CLC GFE++ G +CVD NEC + C C+N+EGSF C+C
Sbjct: 1902 HCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPG-- 1959
Query: 1378 EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYS------GQKGH----------- 1420
+ Q HC + + G +P C GH
Sbjct: 1960 -FQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCF 2018
Query: 1421 -----APCSSVLGRNTTQAECCCTQ--GASWGDACDLCPSEDSAEFSEICPSGKGYIPVE 1473
CS NTT+ CCC++ G WGD C+LCP E SA F E+CP G G +P
Sbjct: 2019 TRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGP 2078
Query: 1474 GAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ 1533
D +EC PG+C NG C+NT + C C G+ D + C D DEC
Sbjct: 2079 ------DDSREDVNECAE-NPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECS 2131
Query: 1534 -----------------DLACENG------------------------ECVNTEGSFHCF 1552
+ AC +G C NTEGS+ C
Sbjct: 2132 VGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCT 2191
Query: 1553 CSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVC-----SEPLRGHRTTYT 1607
C TL C + + D C + C PL G
Sbjct: 2192 CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSG---- 2247
Query: 1608 ECCCQDGEAWSQQCALCPPRSSEVYAQLCNVA---RIEAEREAGVHFRPGYEYGPGPDDL 1664
E C D E +Q LC V + N A R + + G++ P +
Sbjct: 2248 EGCTDDNECHAQP-DLC------VNGRCVNTAGSFRCDCDE--------GFQPSPTLTEC 2292
Query: 1665 HYSIYGPDGAPFYNYLGPEDTVPEPAFPNT---AGHSADRTPILESPLQPSELQPHYVAS 1721
H GP A + + A G P E P +
Sbjct: 2293 HDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCP 2352
Query: 1722 HPEPPAGFEGLQAEECGIL-NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDD 1780
H EG +EC +L + C +G C+ + C C G+ DA C+D++EC
Sbjct: 2353 HGSGYTA-EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQ 2411
Query: 1781 LNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
+ P C+NT+GS+ C C GY+ E C
Sbjct: 2412 VPKPCTF----LCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Score = 472 bits (1215), Expect = e-132
Identities = 406/1428 (28%), Positives = 575/1428 (40%), Gaps = 252/1428 (17%)
Query: 552 GRCYLNTVNGQCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQG 611
G C+L +C L + + +CC ++GA WG + C C PA C +G
Sbjct: 810 GTCWLKIQESRCEVNLQGASLRSECCATLGAAWG-SPCERCEIDPA----------CARG 858
Query: 612 YKRLNLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISML 670
+ R+ C D+NEC + G+C + CVNT GS+ C C GLMLD S CV +
Sbjct: 859 FARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEP-- 916
Query: 671 QGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGY 730
C+ C + L + +CCCS +G WG ECE CP P + F +CP G G+
Sbjct: 917 ---CFLRWDEDECGVTLPGKYRMDVCCCS-IGAVWGVECEACPDPESLEFASLCPRGLGF 972
Query: 731 TYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKG 790
A + L+ P + PG R ++ A
Sbjct: 973 -------------ASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFAL 1019
Query: 791 DSQAGQVTT-SVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCA 849
D+Q T + G T P E + ++ + +D CA
Sbjct: 1020 DAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGY---ESGFMLMKNCMDVDECA 1076
Query: 850 AGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC-LRDPCKGKGRCINRVGS 908
+C GTC N Y+C C PG++L C D +EC L D G+C+N +G+
Sbjct: 1077 RDPL-LCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
Query: 909 YSCFCYPGYTLATSGATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH 967
+ C C+ G+ ++ Q C DINEC Q G C C NTEGSY C C QGY ++ G
Sbjct: 1136 FQCSCHAGFQ--STPDRQGCVDINECRVQNGGCDV-HCINTEGSYRCSCGQGYSLMPDGR 1192
Query: 968 -CQDINECR-HPGTCPDGRCVNSPGSYTCLACEEGYRGQSG--SCVDVNEC-LTPGVCAH 1022
C D++EC +P C G C N PG + CL C +G+ +CVDV+EC L P +C H
Sbjct: 1193 ACADVDECEENPRVCDQGHCTNMPGGHRCL-CYDGFMATPDMRTCVDVDECDLNPHICLH 1251
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA-------SRASC-------------- 1061
G C N +GSF C C+ GY V GC DVDEC S ASC
Sbjct: 1252 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG 1311
Query: 1062 ----------------------PTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF 1099
P G CLN GS+ C+ C G+ DG CED DECA
Sbjct: 1312 WVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCT-CRQGF--AGDGFFCEDRDECAE 1368
Query: 1100 P-GVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY 1158
+C +G C N G + C +C+ G+ P+ +C+DVDEC + C G C+N G +
Sbjct: 1369 NVDLCDNGQCLNAPGGYRC-ECEMGFDPTEDHRACQDVDECAQG-NLCAFGSCENLPGMF 1426
Query: 1159 QCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217
+C+C G++L G C D+NEC +C +G C+N+ GS+ C C F G C
Sbjct: 1427 RCICNGGYELDRGGGNCTDINECADPVNCI-NGVCINTPGSYLCSCPQDFELNPSGVGCV 1485
Query: 1218 DVDE------------------------------CATTDPCVGGHCV------NTEGSFN 1241
D C + G C TE
Sbjct: 1486 DTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTL 1545
Query: 1242 CLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD- 1300
C GFQP+ + DIDEC++ +C C N+ GS++C C PG+H++ +
Sbjct: 1546 CPGGEGFQPNRITVILEDIDECQELPG-LCQGGDCVNTFGSFQCE--CPPGYHLSEHTRI 1602
Query: 1301 CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELML---AVCG 1357
C DIDEC+ + G C NT G++ C+C + G +C+D+ + C
Sbjct: 1603 CEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQ 1662
Query: 1358 AALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMS---EAPTGDHAPAPTRMDCY 1414
L NV +C C+ Y+ + RP A +S + G+ AP D +
Sbjct: 1663 NELAFNVTRK-MCCCS-----YNIGQAWNRPCEACPTPISPDYQILCGNQAPG-FLTDIH 1715
Query: 1415 SGQK------GHAPCSSVLGRNTTQA---ECCCTQGASWGD---AC---DLC-----PSE 1454
+G+ G P G Q C C G ++ AC D C P +
Sbjct: 1716 TGKPLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQ 1775
Query: 1455 DSAEFSEI-----CPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGY 1509
+A+ I C +GY G G+ +EC P +C +G C++T Y
Sbjct: 1776 QNADCINIPGSYRCKCTRGYKLSPGGACVGR------NECREI-PNVCSHGDCMDTEGSY 1828
Query: 1510 VCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLT-------LDLS 1562
+CLC+ GF A C D DEC C NG C N GS++C C P +D
Sbjct: 1829 MCLCHRGFQASADQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFD 1888
Query: 1563 Q-----------QRCMNSTSSTEDLPDHDIHMDICWKKV--TNDVCSEPLRGHRTTYTEC 1609
+ C+N+ S L + K TN+ S L G T
Sbjct: 1889 ECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLS--LAG---TCLPG 1943
Query: 1610 CCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPG--------- 1660
CQ+ E S +C +CPP +V + C + E E + PG
Sbjct: 1944 TCQNLEG-SFRC-ICPP-GFQVQSDHC-IDIDECSEEPNLCLFGTCTNSPGSFQCLCPPG 1999
Query: 1661 ---PDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPH 1717
D+ H F + + +VP+ AF T E P EL P
Sbjct: 2000 FVLSDNGHRCFDTRQSFCFTRFEAGKCSVPK-AFNTTKTRCCCSKRPGEGWGDPCELCPQ 2058
Query: 1718 YVASHPEPPAGFEGLQAEECGILNGCENGR-----------------CVRVREGYTCDCF 1760
E A F+ L G + G ++ R CV + C+C
Sbjct: 2059 ------EGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECP 2112
Query: 1761 EGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
G+ LD + CVD +EC + P C G C N G + C C+ G+
Sbjct: 2113 FGYSLDFTGINCVDTDEC-SVGHP---CGQGTCTNVIGGFECACADGF 2156
Score = 461 bits (1185), Expect = e-129
Identities = 401/1393 (28%), Positives = 558/1393 (40%), Gaps = 259/1393 (18%)
Query: 552 GRCYLNTVNGQCANPLLELT-TQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQ 610
G C+ C + L L T+ CC +VG WG+ C CP +P C +
Sbjct: 185 GPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLP-CELCPAQPHP---------CRR 234
Query: 611 GY-KRLNLTHCQDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAIS 668
G+ ++ CQD++EC + GLC+ CVN GS+ C C G L S + C +A
Sbjct: 235 GFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAACEDYRA-- 292
Query: 669 MLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC-PAG 727
G C+ L G C LA T++ CCC R G+ W + P+P E+C P G
Sbjct: 293 ---GACFSVLFGGRCAGDLAGHYTRRQCCCDR-GRCWAAG----PVP------ELCPPRG 338
Query: 728 HGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALP--GPAERQPLRVVTDTWLEAGT 785
RL + P G S+G P GPA P +A
Sbjct: 339 SNEFQQLCAQRLPLLPGHPGLF---PGLLGFGSNGMGPPLGPARLNP------HGSDARG 389
Query: 786 IPD--KGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP 843
IP G+S G T + T
Sbjct: 390 IPSLGPGNSNIGTATLNQT----------------------------------------- 408
Query: 844 GIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903
ID C TN+C G C+ P YRC C+ GY + C D +EC PC G C+
Sbjct: 409 -IDICRH-FTNLCLNGRCLPTPSSYRCECNVGY-TQDVRGECIDVDECTSSPCH-HGDCV 464
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIM 962
N G+Y C CYPG+ + Q C D++EC G+C G+C NTEGS+ C C+ G+ +
Sbjct: 465 NIPGTYHCRCYPGF--QATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFEL 522
Query: 963 VRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGS--CVDVNECLTPGV 1019
G +C D NEC C +G C+N GS++CL C+ G+ G C+D++EC TPG+
Sbjct: 523 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCL-CKPGFLLAPGGHYCMDIDECQTPGI 581
Query: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDV------------DECA-------SRAS 1060
C +G CTN EGSFRC C G V +D + C D CA +++
Sbjct: 582 CVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSE 641
Query: 1061 C-----------PTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPSGVC 1108
C P LC + + + C +G + DG D++ECA P VC +GVC
Sbjct: 642 CCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDG---RDINECALDPEVCANGVC 698
Query: 1109 TNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL 1168
N GS+ C C+ GY G C DVDEC C G C+N+ GSY C CP GF
Sbjct: 699 ENLRGSYRCV-CNLGYEAGASGKDCTDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHF 757
Query: 1169 ANGT-VCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDE------ 1221
T +C+DV+EC+ G C N GS+ C C PG GT C D +
Sbjct: 758 WQDTEICKDVDECLSSP--CVSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLK 815
Query: 1222 -------------------CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE 1262
CAT G C E + C GF C D++E
Sbjct: 816 IQESRCEVNLQGASLRSECCATLGAAWGSPCERCE--IDPACARGF-ARMTGVTCDDVNE 872
Query: 1263 CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDI-----------DECA-- 1308
CE + VC +C N+ GS+RC C G + +G C+D+ DEC
Sbjct: 873 CESF-PGVCPNGRCVNTAGSFRC--ECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVT 929
Query: 1309 ------NDTMCGSHG--------FCDNTDG-SFRCLCDQGFEISPSGW-----DCVDVNE 1348
D C S G C + + F LC +G + + DVNE
Sbjct: 930 LPGKYRMDVCCCSIGAVWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNE 989
Query: 1349 CELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGD--HAP 1406
C++ +C C N GSF C CA DAQE +C S G + P
Sbjct: 990 CKVFPGLCTHGTCRNTVGSFHCACAGGF-ALDAQERNCTDIDECRISPDLCGQGTCVNTP 1048
Query: 1407 APTRMDCYSGQKGHAPCSSVLGRNTTQA-ECCCTQGASWGDACDLCPSEDSAEFSEICPS 1465
+C+ G + +L +N EC G C + + CP
Sbjct: 1049 GSFECECFPGYES----GFMLMKNCMDVDECARDPLLCRGGTC----TNTDGSYKCQCPP 1100
Query: 1466 GKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKK 1525
G T T D DEC + GLCP+G+C+N + + C C+ GF +
Sbjct: 1101 GH-------ELTAKGTACEDIDECSL-SDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQG 1152
Query: 1526 CEDHDEC--QDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHM 1583
C D +EC Q+ C+ C+NTEGS+ C C +L + C D+ + + +
Sbjct: 1153 CVDINECRVQNGGCD-VHCINTEGSYRCSCGQGYSLMPDGRAC-------ADVDECEENP 1204
Query: 1584 DICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC-PPRSSEVYAQLCNVARIE 1642
+C C+ GHR C C DG + C ++ +C E
Sbjct: 1205 RVC----DQGHCTNMPGGHR-----CLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCE 1255
Query: 1643 AEREAGV-HFRPGYEYGPG----PDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGH 1697
+ + V H + GY G D + G + + L + P G
Sbjct: 1256 NTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD 1315
Query: 1698 SADRTPILESPLQPSELQPH---------YVASHPEPPA--GFEGLQAEECG-ILNGCEN 1745
+ + E Q P Y + + A GF +EC ++ C+N
Sbjct: 1316 GFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCDN 1375
Query: 1746 GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCS 1805
G+C+ GY C+C GF H AC DV+EC N LC G CEN G +RC C+
Sbjct: 1376 GQCLNAPGGYRCECEMGFDPTEDHRACQDVDECAQGN----LCAFGSCENLPGMFRCICN 1431
Query: 1806 PGYVAEAGPPHCT 1818
GY + G +CT
Sbjct: 1432 GGYELDRGGGNCT 1444
Score = 439 bits (1128), Expect = e-122
Identities = 335/1119 (29%), Positives = 467/1119 (41%), Gaps = 254/1119 (22%)
Query: 552 GRCYLNTVNG-----QCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQL 606
G C+L T + C+ + T+ CC S+G WG PC P + E L
Sbjct: 1490 GNCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWG----NPCELCPMANTTEYRTL 1545
Query: 607 ECP--QGYKRLNLTHC-QDINECLTL-GLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
CP +G++ +T +DI+EC L GLC+ +CVNT GS+ C C PG L C
Sbjct: 1546 -CPGGEGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICE 1604
Query: 663 SDKAISMLQGLC-----YRSLGPGTCTLP------------------------------- 686
S G+C Y +LG TC P
Sbjct: 1605 DIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNE 1664
Query: 687 LAQRITKQICCCS-RVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAE 745
LA +T+++CCCS +G+AW C E CP T S D ++
Sbjct: 1665 LAFNVTRKMCCCSYNIGQAWNRPC------------EACP-----TPISPDYQILC---- 1703
Query: 746 EEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPD--KGDSQAGQVTTSVTH 803
G ++ G L +PL + E G IP Q+ +
Sbjct: 1704 -----------GNQAPGFLTDIHTGKPLDID-----ECGEIPAICANGICINQIGSFRCE 1747
Query: 804 APAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863
PA N+ + L+ +D C + + C+N
Sbjct: 1748 CPAGFNYNS-------------------------ILLACEDVDECGSRESPCQQNADCIN 1782
Query: 864 LPDGYRCVCSPGYQLHPSQAYCTDDNECLRDP-CKGKGRCINRVGSYSCFCYPGYTLATS 922
+P YRC C+ GY+L P A C NEC P G C++ GSY C C+ G+ S
Sbjct: 1783 IPGSYRCKCTRGYKLSPGGA-CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGF--QAS 1839
Query: 923 GATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRH--PGT 979
C DI+EC+ QP C G C N GSY+C C G+++ G C D +EC
Sbjct: 1840 ADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQV 1897
Query: 980 CPDGRCVNSPGSYTCLACEEGYR--GQSGSCVDVNECLT-PGVCAHGKCTNLEGSFRCSC 1036
C G C+N+ GS+ CL C++G+ +CVD NECL+ G C G C NLEGSFRC C
Sbjct: 1898 CRFGHCLNTAGSFHCL-CQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCIC 1956
Query: 1037 EQGYEVTSDEKGCQDVDECASRAS-CPTGLCLNTEGSFACSACENGYWVNEDGTACED-- 1093
G++V SD C D+DEC+ + C G C N+ GSF C C G+ ++++G C D
Sbjct: 1957 PPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQC-LCPPGFVLSDNGHRCFDTR 2013
Query: 1094 ---------LDECAFPGVC-------------------PSGVCTNTAGSFSCKDCDGGYR 1125
+C+ P P +C + + C G+
Sbjct: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073
Query: 1126 PSP-LGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGE 1183
P DS EDV+EC + C G C NT GS++C CP G+ L G C D +EC
Sbjct: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVG 2133
Query: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGG--TSCQDVDECATTDPCVGGHCVNTEGSFN 1241
C G C N G F C CA GF E G +C+D+DEC+ C NTEGS+
Sbjct: 2134 HPCG-QGTCTNVIGGFECACADGF---EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYL 2189
Query: 1242 CLCETGFQPSPESGECVDIDECEDYGDPVCGT--WKCENSPGSYRCVLGCQPGFHMAPNG 1299
C C G+ + C D+DEC D G C +C+N G++ CV C PG P
Sbjct: 2190 CTCPAGYTLREDGAMCRDVDECAD-GQQDCHARGMECKNLIGTFACV--CPPGMRPLPGS 2246
Query: 1300 --DCIDIDEC-ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVC 1356
C D +EC A +C +G C NT GSFRC CD+GF+ SP+ +C D+ + C
Sbjct: 2247 GEGCTDDNECHAQPDLC-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ-----GPC 2300
Query: 1357 GAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSG 1416
A + + + CR + ++++ A
Sbjct: 2301 FAEVLQTM---------------------CRSLSSSSEAVTRA----------------- 2322
Query: 1417 QKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAW 1476
ECCC G WG C+LCP ++ + ++CP G GY EG
Sbjct: 2323 ------------------ECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGY-TAEG-- 2361
Query: 1477 TFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDL- 1535
D DEC + LC +G C+N++ + C C G+ DA+ C D DEC +
Sbjct: 2362 -------RDVDECRMLA-HLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVP 2413
Query: 1536 -ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSST 1573
C C NT+GSF C C L+ + C + T
Sbjct: 2414 KPC-TFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECT 2451
Score = 436 bits (1120), Expect = e-121
Identities = 297/886 (33%), Positives = 385/886 (43%), Gaps = 158/886 (17%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
+D CA + +C G C N P Y C C PG+ C D +ECL PC G C N
Sbjct: 725 VDECALNSL-LCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVCRN 782
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINE-----------CEQ--PGVCSGGQCTNTEGS 951
GSY+C C PG L SG C D + CE G +C T G+
Sbjct: 783 LAGSYTCKCGPGSRLDPSGTF--CLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGA 840
Query: 952 Y------HCE----CDQGYIMVRKGHCQDINECRH-PGTCPDGRCVNSPGSYTCLACEEG 1000
CE C +G+ + C D+NEC PG CP+GRCVN+ GS+ C C EG
Sbjct: 841 AWGSPCERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC-ECPEG 899
Query: 1001 YRGQSGS--CVDV-----------NECLTPGVCAHGK--------------------CTN 1027
+ CVDV +EC GV GK C +
Sbjct: 900 LMLDASGRLCVDVRLEPCFLRWDEDEC---GVTLPGKYRMDVCCCSIGAVWGVECEACPD 956
Query: 1028 LEG-SFRCSCEQGY-----EVTSDEKGCQDVDEC-ASRASCPTGLCLNTEGSFACSACEN 1080
E F C +G + S +DV+EC C G C NT GSF C AC
Sbjct: 957 PESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHC-ACAG 1015
Query: 1081 GYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPS-PLGDSCEDVDE 1138
G+ ++ C D+DEC P +C G C NT GSF C +C GY L +C DVDE
Sbjct: 1016 GFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFEC-ECFPGYESGFMLMKNCMDVDE 1074
Query: 1139 CEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHG 1197
C C GG C NT GSY+C CP G +L A GT CED++EC + PHG+C+N G
Sbjct: 1075 CARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIG 1134
Query: 1198 SFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGEC 1257
+F C C GF S C D++EC + HC+NTEGS+ C C G+ P+ C
Sbjct: 1135 AFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC 1194
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN-GDCIDIDECANDTMCGSH 1316
D+DECE+ VC C N PG +RC+ C GF P+ C+D+DEC + H
Sbjct: 1195 ADVDECEE-NPRVCDQGHCTNMPGGHRCL--CYDGFMATPDMRTCVDVDECDLNPHICLH 1251
Query: 1317 GFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA-ALCENVEGSFLCLC--- 1372
G C+NT GSF C C G+ + C DV+ECE+ C + A C N+ GSF C C
Sbjct: 1252 GDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG 1311
Query: 1373 -------ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSS 1425
DL+E +QE C PRG C +
Sbjct: 1312 WVGDGFECHDLDECVSQEHRCSPRG-------------------------------DCLN 1340
Query: 1426 VLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGK--------------GYIP 1471
V G C C QG + GD ++ AE ++C +G+ G+ P
Sbjct: 1341 VPG----SYRCTCRQGFA-GDGFFCEDRDECAENVDLCDNGQCLNAPGGYRCECEMGFDP 1395
Query: 1472 VEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDE 1531
E D DEC LC G C N + C+CN G+ D C D +E
Sbjct: 1396 TE-----DHRACQDVDECA--QGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINE 1448
Query: 1532 CQD-LACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKV 1590
C D + C NG C+NT GS+ C C L+ S C+++ + L HD +
Sbjct: 1449 CADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHD-------RGD 1501
Query: 1591 TNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLC 1636
+ CS + G T CCC G AW C LCP ++ Y LC
Sbjct: 1502 SGISCSAEI-GVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLC 1546
Score = 412 bits (1060), Expect = e-114
Identities = 326/1049 (31%), Positives = 434/1049 (41%), Gaps = 194/1049 (18%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRC 902
ID C +C G C+N +RC C G+ + C D +EC PC+ C
Sbjct: 1722 IDECGE-IPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADC 1780
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQ-PGVCSGGQCTNTEGSYHCECDQGY- 960
IN GSY C C GY L+ GA C NEC + P VCS G C +TEGSY C C +G+
Sbjct: 1781 INIPGSYRCKCTRGYKLSPGGA---CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQ 1837
Query: 961 IMVRKGHCQDINEC-RHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLT--P 1017
+ C DI+EC R P C +G C N GSY CL +G CVD +EC T
Sbjct: 1838 ASADQTLCMDIDECDRQP--CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVG 1895
Query: 1018 GVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTGLCLNTEGSFACS 1076
VC G C N GSF C C+ G+E+T+D K C D +EC S A +C G C N EGSF C
Sbjct: 1896 QVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRC- 1954
Query: 1077 ACENGYWVNEDGTACEDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCED 1135
C G+ V D C D+DEC+ P +C G CTN+ GSF C C G+ S G C D
Sbjct: 1955 ICPPGFQVQSDH--CIDIDECSEEPNLCLFGTCTNSPGSFQCL-CPPGFVLSDNGHRCFD 2011
Query: 1136 VDECEDPQSSCL----GGECK-----NTVGSYQC--------------LCPQGFQLANGT 1172
QS C G+C NT + C LCPQ A
Sbjct: 2012 TR-----QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQE 2066
Query: 1173 VC--------------EDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
+C EDVNEC +G C+N+ GSF C C G+ G +C D
Sbjct: 2067 LCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVD 2126
Query: 1219 VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCEN 1278
DEC+ PC G C N G F C C GF+P C DIDEC +P+ ++C N
Sbjct: 2127 TDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMM-TCEDIDECSL--NPLLCAFRCHN 2183
Query: 1279 SPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTM-CGSHGF-CDNTDGSFRCLCDQGFE 1335
+ GSY C C G+ + +G C D+DECA+ C + G C N G+F C+C G
Sbjct: 2184 TEGSYLCT--CPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMR 2241
Query: 1336 ISP-SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQ 1394
P SG C D NEC +C C N GSF C C +
Sbjct: 2242 PLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQ----------------- 2284
Query: 1395 SMSEAPTGDHAPAPTRMDCYSGQKG-------HAPCSSVLGRN--TTQAECCCTQGASWG 1445
P+PT +C+ ++G C S+ + T+AECCC G WG
Sbjct: 2285 -----------PSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWG 2333
Query: 1446 DACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNT 1505
C+LCP ++ + + LCP+G
Sbjct: 2334 PRCELCPLPGTSAYRK----------------------------------LCPHGS---- 2355
Query: 1506 VPGYVCLCNPGFHYDASHKKCEDHDECQDLA--CENGECVNTEGSFHCFCSPPLTLDLSQ 1563
GY + D DEC+ LA C +GEC+N+ GSF C C T D +
Sbjct: 2356 --GYTA-------------EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATA 2400
Query: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQD-GEAWSQQ-- 1620
C++ ++ +P + C + +CS P RG+ C+D E S+Q
Sbjct: 2401 TTCLDMDECSQ-VPKPCTFL--CKNTKGSFLCSCP-RGYLLEEDGRTCKDLDECTSRQHN 2456
Query: 1621 CA-LCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNY 1679
C LC + V A C + PGP H + G+ F
Sbjct: 2457 CQFLCV---NTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGS-FRCE 2512
Query: 1680 LGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHP-EPPAGF-------EG 1731
T+ ++GH + + P + + + + P GF +
Sbjct: 2513 CHQGFTLV------SSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQC 2566
Query: 1732 LQAEECGILNG-CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790
+ EC + C + C G+ C C GF D A C +V+EC GP C +
Sbjct: 2567 VDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAGRRGP---CSY 2623
Query: 1791 GYCENTEGSYRCHCSPGYVAEAGPPHCTA 1819
C NT G + C C GY AG HC +
Sbjct: 2624 S-CANTPGGFLCGCPQGYF-RAGQGHCVS 2650
Score = 387 bits (994), Expect = e-107
Identities = 339/1102 (30%), Positives = 445/1102 (40%), Gaps = 229/1102 (20%)
Query: 868 YRCVCSPGYQLHPSQ--AYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPGYTLATSG 923
YR +C G P++ D +EC P C+G G C+N GS+ C C PGY L S
Sbjct: 1542 YRTLCPGGEGFQPNRITVILEDIDECQELPGLCQG-GDCVNTFGSFQCECPPGYHL--SE 1598
Query: 924 ATQECQDINECE-QPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQDINEC----RHP 977
T+ C+DI+EC G+C G C NT G+Y C C Y+ V G+ C D+ + +
Sbjct: 1599 HTRICEDIDECSTHSGICGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYN 1658
Query: 978 GTCPDGRCVNSPGSYTCLACEEGYRGQ------------------------------SGS 1007
GTC + N C + G +G
Sbjct: 1659 GTCQNELAFNVTRKMCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGK 1718
Query: 1008 CVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRAS-CPTGL 1065
+D++EC P +CA+G C N GSFRC C G+ S C+DVDEC SR S C
Sbjct: 1719 PLDIDECGEIPAICANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNA 1778
Query: 1066 -CLNTEGSFACSACENGYWVNEDGTACEDLDECA-FPGVCPSGVCTNTAGSFSCKDCDGG 1123
C+N GS+ C C GY ++ G AC +EC P VC G C +T GS+ C C G
Sbjct: 1779 DCINIPGSYRCK-CTRGYKLSPGG-ACVGRNECREIPNVCSHGDCMDTEGSYMCL-CHRG 1835
Query: 1124 YRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNEC--- 1180
++ S C D+DEC+ + C G CKN +GSY CLC GF + + C D +EC
Sbjct: 1836 FQASADQTLCMDIDECD--RQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTL 1893
Query: 1181 MGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPCVGGHCVNTEGS 1239
+G+ G CLN+ GSF CLC GF G +C D +EC + C+ G C N EGS
Sbjct: 1894 VGQ--VCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGS 1951
Query: 1240 FNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG 1299
F C+C GFQ +S C+DIDEC + + +C C NSPGS++C+ C PGF ++ NG
Sbjct: 1952 FRCICPPGFQV--QSDHCIDIDECSEEPN-LCLFGTCTNSPGSFQCL--CPPGFVLSDNG 2006
Query: 1300 D-CIDIDECANDTMCGSHGFCD-----NTDGSFRCLCD----QGF--------------- 1334
C D + T + G C NT + RC C +G+
Sbjct: 2007 HRCFDTRQSFCFTRFEA-GKCSVPKAFNTTKT-RCCCSKRPGEGWGDPCELCPQEGSAAF 2064
Query: 1335 -EISPSGWDCV--------DVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGH 1385
E+ P G V DVNEC VC +C N +GSF C C
Sbjct: 2065 QELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPF----------- 2113
Query: 1386 CRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQK-GHAPCSSVLGRNTTQAECCCTQGASW 1444
G S+ TG + +C G G C++V+G EC C G
Sbjct: 2114 -------GYSLDF--TGINCVDTD--ECSVGHPCGQGTCTNVIGG----FECACADGFEP 2158
Query: 1445 G--------DACDLCPSE-----DSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVI 1491
G D C L P + E S +C GY E M D DEC
Sbjct: 2159 GLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDG-----AMCRDVDECAD 2213
Query: 1492 FGPGLCPNG-RCLNTVPGYVCLCNPGFH-YDASHKKCEDHDEC--QDLACENGECVNTEG 1547
G C N + + C+C PG S + C D +EC Q C NG CVNT G
Sbjct: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAG 2273
Query: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVC-SEPLRGHRTTY 1606
SF C C + C HDI C+ +V +C S T
Sbjct: 2274 SFRCDCDEGFQPSPTLTEC------------HDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
Query: 1607 TECCCQDGEAWSQQCA------------LCPPRSS-----------EVYAQLCNVARIEA 1643
ECCC G W +C LCP S + A LC A E
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC--AHGEC 2379
Query: 1644 EREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAF---PNTAGH--- 1697
G FR + G PD + D VP+P NT G
Sbjct: 2380 INSLG-SFRCHCQAGYTPDATATTCLDMDEC---------SQVPKPCTFLCKNTKGSFLC 2429
Query: 1698 SADRTPILESPLQPSELQPHYVASHPE----------------PPAGFEGLQA----EEC 1737
S R +LE + + + PP + QA +EC
Sbjct: 2430 SCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDEC 2489
Query: 1738 GILNG-C-ENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
G C +G C + C+C +GF L ++ C DVNECD GP C HG C+N
Sbjct: 2490 SAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECD---GPH-RCQHG-CQN 2544
Query: 1796 TEGSYRCHCSPGYVAEAGPPHC 1817
G YRC C G+ + C
Sbjct: 2545 QLGGYRCSCPQGFTQHSQWAQC 2566
Score = 342 bits (878), Expect = 1e-93
Identities = 270/876 (30%), Positives = 359/876 (40%), Gaps = 162/876 (18%)
Query: 846 DRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNEC--LRDPCKGKGRCI 903
D C VC G C+N + C+C G++L C D NEC L C G C
Sbjct: 1888 DECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCL-PGTCQ 1946
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQCTNTEGSYHCECDQGYIM 962
N GS+ C C PG+ + + C DI+EC E+P +C G CTN+ GS+ C C G+++
Sbjct: 1947 NLEGSFRCICPPGFQV----QSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVL 2002
Query: 963 VRKGH-CQDINEC-----RHPGTCPDGRCVNSPGSYTC--------------LACEEG-- 1000
GH C D + G C + N+ + C L +EG
Sbjct: 2003 SDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSA 2062
Query: 1001 ------------YRGQSGSCVDVNECL-TPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEK 1047
G S DVNEC PGVC +G C N +GSFRC C GY +
Sbjct: 2063 AFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGI 2122
Query: 1048 GCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDG--TACEDLDECAFPGVCPS 1105
C D DEC+ C G C N G F C AC +G+ E G CED+DEC+ + +
Sbjct: 2123 NCVDTDECSVGHPCGQGTCTNVIGGFEC-ACADGF---EPGLMMTCEDIDECSLNPLLCA 2178
Query: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC--LGGECKNTVGSYQCLCP 1163
C NT GS+ C C GY G C DVDEC D Q C G ECKN +G++ C+CP
Sbjct: 2179 FRCHNTEGSYLC-TCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCP 2237
Query: 1164 QGFQ--LANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDV-- 1219
G + +G C D NEC + +G C+N+ GSF C C GF + T C D+
Sbjct: 2238 PGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQ 2297
Query: 1220 ------------------DECATTDPCV-------GGHC----VNTEGSFNCLCETGFQP 1250
E T C G C + ++ LC G
Sbjct: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHG--- 2354
Query: 1251 SPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN 1309
S + E D+DEC +C +C NS GS+RC CQ G+ A C+D+DEC+
Sbjct: 2355 SGYTAEGRDVDECRMLAH-LCAHGECINSLGSFRC--HCQAGYTPDATATTCLDMDECSQ 2411
Query: 1310 DTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFL 1369
+ C NT GSF C C +G+ + G C D++EC C LC N G+F
Sbjct: 2412 VPKPCTF-LCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC-QFLCVNTVGAFT 2469
Query: 1370 CLC----------ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSG--- 1416
C C D +E AQ G C GA G + P R +C+ G
Sbjct: 2470 CRCPPGFTQHHQACFDNDECSAQPGPC---GAHGHC-------HNTPGSFRCECHQGFTL 2519
Query: 1417 -QKGHAPCSSVL---GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPV 1472
GH C V G + Q C Q G C CP G
Sbjct: 2520 VSSGHG-CEDVNECDGPHRCQHGC---QNQLGGYRCS-------------CPQG---FTQ 2559
Query: 1473 EGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC 1532
W D +EC + P C + C NT+ G+ C+C GF +D + C++ DEC
Sbjct: 2560 HSQW----AQCVDENECAL-SPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
Query: 1533 QDLACENG----ECVNTEGSFHCFCSPPLTLDLSQQRCMNS---TSSTEDLPDHD--IHM 1583
A G C NT G F C C P Q C++ + +D PD + +
Sbjct: 2615 ---AGRRGPCSYSCANTPGGFLCGC-PQGYFRAGQGHCVSGLGFSPGPQDTPDKEELLSS 2670
Query: 1584 DICWKKVTNDVC--SEPLR-GHRTTYTECCCQDGEA 1616
+ C++ N + P R HR D EA
Sbjct: 2671 EACYECKINGLSPRDRPRRSAHRDHQVNLATLDSEA 2706
Score = 327 bits (839), Expect = 5e-89
Identities = 239/706 (33%), Positives = 311/706 (44%), Gaps = 144/706 (20%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE-------------- 890
ID C+ N+C GTC N P ++C+C PG+ L + C D +
Sbjct: 1970 IDECSE-EPNLCLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSV 2028
Query: 891 ------------CLRDPCKGKG---RCINRVGS--YSCFCYPGYTLATSGATQECQDINE 933
C + P +G G + GS + C G+ A G +D+NE
Sbjct: 2029 PKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG-AVPGPDDSREDVNE 2087
Query: 934 C-EQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGS 991
C E PGVC+ G C NT+GS+ CEC GY + G +C D +EC C G C N G
Sbjct: 2088 CAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGG 2147
Query: 992 YTCLACEEGYR-GQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049
+ C AC +G+ G +C D++EC L P +CA +C N EGS+ C+C GY + D C
Sbjct: 2148 FEC-ACADGFEPGLMMTCEDIDECSLNPLLCAF-RCHNTEGSYLCTCPAGYTLREDGAMC 2205
Query: 1050 QDVDECAS-RASCPT-GL-CLNTEGSFACSACENGYWVNEDGTACEDLDEC-AFPGVCPS 1105
+DVDECA + C G+ C N G+FAC + G C D +EC A P +C +
Sbjct: 2206 RDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVN 2265
Query: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDE-----------CEDPQSS--------- 1145
G C NTAGSF C DCD G++PSP C D+ + C SS
Sbjct: 2266 GRCVNTAGSFRC-DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAEC 2324
Query: 1146 CLGG------ECKNT----VGSYQCLCPQGFQLANGTVCE--DVNECMGEEHCAPHGECL 1193
C GG C+ +Y+ LCP G +G E DV+EC H HGEC+
Sbjct: 2325 CCGGGRGWGPRCELCPLPGTSAYRKLCPHG----SGYTAEGRDVDECRMLAHLCAHGECI 2380
Query: 1194 NSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPE 1253
NS GSF C C G+ T+C D+DEC+ C NT+GSF C C G+ +
Sbjct: 2381 NSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEED 2440
Query: 1254 SGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF---HMAPNGDCIDIDEC-AN 1309
C D+DEC + C N+ G++ C C PGF H A C D DEC A
Sbjct: 2441 GRTCKDLDECTSRQHNC--QFLCVNTVGAFTC--RCPPGFTQHHQA----CFDNDECSAQ 2492
Query: 1310 DTMCGSHGFCDNTDGSFRCLCDQGFEISPSG----------------------------- 1340
CG+HG C NT GSFRC C QGF + SG
Sbjct: 2493 PGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCS 2552
Query: 1341 ----------W-DCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRP- 1388
W CVD NEC L CG+A C N G F C+C S ++D G C+
Sbjct: 2553 CPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGF-DFDQALGGCQEV 2611
Query: 1389 ------RGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLG 1428
RG S + P G P + +GH C S LG
Sbjct: 2612 DECAGRRGPCSYSCANTPGGFLCGCP--QGYFRAGQGH--CVSGLG 2653
Score = 300 bits (769), Expect = 7e-81
Identities = 251/914 (27%), Positives = 339/914 (37%), Gaps = 236/914 (25%)
Query: 857 GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPG 916
GP C + Y C PG++ P ++ C R C G+G C C C G
Sbjct: 56 GPNVCGSRFHAY---CCPGWRTFPGRSQCVVP--ICRRAC-GEGFCSQ---PNLCTCADG 106
Query: 917 YTLATSGATQECQDINECEQPGVCSGGQC------TNTE-----------------GSYH 953
+ G ++ C G C G C T T G
Sbjct: 107 TLAPSCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPNR 166
Query: 954 CECDQGYI------MVRKGHC---QDINECRHPGT---CPDGRCVNSPGSYTCLACE--- 998
C C G++ R G C C+H T C C + G L CE
Sbjct: 167 CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCP 226
Query: 999 -------EGY--RGQSGSCVDVNEC-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKG 1048
G+ +G+C DV+EC PG+C G C N+ GSF C C G+ ++
Sbjct: 227 AQPHPCRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVGHRLSDSSAA 286
Query: 1049 CQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDEC----AFPGVCP 1104
C+D G C + C+ G++ C D C P +CP
Sbjct: 287 CEDY---------RAGACFSVLFGGRCAGDLAGHYTRRQ--CCCDRGRCWAAGPVPELCP 335
Query: 1105 -------SGVCTNTA----------------GSFSCKDCDGGYRPSPLGDSC-------- 1133
+C GS G R +P G
Sbjct: 336 PRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGP 395
Query: 1134 -----------EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMG 1182
+ +D C + CL G C T SY+C C G+ C DV+EC
Sbjct: 396 GNSNIGTATLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTS 455
Query: 1183 EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDP-CVGGHCVNTEGSFN 1241
HG+C+N G++ C C PGF + +C DVDEC + C G CVNTEGSF
Sbjct: 456 SP--CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQ 513
Query: 1242 CLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD- 1300
C+C GF+ SP+ CVD +EC +C C N GS+ C+ C+PGF +AP G
Sbjct: 514 CVCNAGFELSPDGKNCVDHNECAT--STMCVNGVCLNEDGSFSCL--CKPGFLLAPGGHY 569
Query: 1301 CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAAL 1360
C+DIDEC +C +G C NT+GSFRC C G + G CVD + + + C A+
Sbjct: 570 CMDIDECQTPGIC-VNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTH----VRSTCYGAI 624
Query: 1361 CENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGH 1420
++G C G + SE
Sbjct: 625 ---------------------EKGSCARPFPGTVTKSEC--------------------- 642
Query: 1421 APCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEG------ 1474
CC +G+ C LCP++DSAEF +C SG G I +G
Sbjct: 643 ---------------CCANPDHGFGEPCQLCPAKDSAEFQALCSSGLG-ITTDGRDINEC 686
Query: 1475 ----------------------------AWTFGQTMYTDADECVIFGPGLCPNGRCLNTV 1506
A G+ TD DEC + LC NG C N+
Sbjct: 687 ALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDC-TDVDECAL-NSLLCDNGWCQNSP 744
Query: 1507 PGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRC 1566
Y C C PGFH+ + C+D DEC C +G C N GS+ C C P LD S C
Sbjct: 745 GSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSYTCKCGPGSRLDPSGTFC 804
Query: 1567 MNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALC-- 1624
++ST T CW K+ C L+G + +ECC G AW C C
Sbjct: 805 LDSTKGT------------CWLKIQESRCEVNLQG-ASLRSECCATLGAAWGSPCERCEI 851
Query: 1625 PPRSSEVYAQLCNV 1638
P + +A++ V
Sbjct: 852 DPACARGFARMTGV 865
Score = 62.0 bits (149), Expect = 5e-09
Identities = 49/161 (30%), Positives = 62/161 (38%), Gaps = 9/161 (5%)
Query: 515 LPASPGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQE 574
LP PGH + S PL PA P G R + G L
Sbjct: 350 LPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTI 409
Query: 575 DCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKD 634
D C F + L C P P+S + EC GY + C D++EC T C
Sbjct: 410 DICRH---FTNLCLNGRCLPTPSSY-----RCECNVGYTQDVRGECIDVDEC-TSSPCHH 460
Query: 635 AECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCY 675
+CVN G+Y C C PG P+R CV + GLC+
Sbjct: 461 GDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCH 501
Score = 58.9 bits (141), Expect = 4e-08
Identities = 26/62 (41%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 161 GRLTGRNVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGA 216
G L G NVCG + CCPGW T + C+ P+C C G CS+P LC C G
Sbjct: 52 GILQGPNVCGSRFHAYCCPGWRTFPGRSQCVVPICRRAC-GEGFCSQPNLCTCADGTLAP 110
Query: 217 RC 218
C
Sbjct: 111 SC 112
Score = 55.5 bits (132), Expect = 5e-07
Identities = 46/185 (24%), Positives = 72/185 (38%), Gaps = 16/185 (8%)
Query: 552 GRCYLNTVNGQCAN--PLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECP 609
G C+ + C + E T+ +CC G WG C CP P + CP
Sbjct: 2298 GPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPR-CELCP----LPGTSAYRKLCP 2352
Query: 610 QGYKRLNLTHCQDINECLTLG-LCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAIS 668
G +D++EC L LC EC+N+ GS+ C C+ G D + + C+ S
Sbjct: 2353 HGSGYT--AEGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECS 2410
Query: 669 MLQG----LCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFRE 722
+ LC + G C+ P + + C + + + C+ + AF
Sbjct: 2411 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFLCVNTVGAFTC 2470
Query: 723 ICPAG 727
CP G
Sbjct: 2471 RCPPG 2475
Score = 48.5 bits (114), Expect = 6e-05
Identities = 25/83 (30%), Positives = 37/83 (44%), Gaps = 6/83 (7%)
Query: 1743 CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRC 1802
C +G C + + C C G+ + C DV+EC+ G H C N GS+ C
Sbjct: 1249 CLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECE--VGGHNCDSHASCLNIPGSFSC 1306
Query: 1803 HCSPGYVAEAGPPH----CTAKE 1821
C PG+V + H C ++E
Sbjct: 1307 RCLPGWVGDGFECHDLDECVSQE 1329
Score = 43.1 bits (100), Expect = 0.002
Identities = 45/173 (26%), Positives = 62/173 (35%), Gaps = 11/173 (6%)
Query: 543 AAPRPRGLLGRCYLNTVNGQC-ANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVI 601
A P P G G C+ + +C + L + C V G C +
Sbjct: 2491 AQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQ----HGCQNQL 2546
Query: 602 ENGQLECPQGY-KRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659
+ CPQG+ + C D NEC L+ C A C NT G + C C G D +
Sbjct: 2547 GGYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALG 2606
Query: 660 RCVSDKAISMLQGLCYRSLG--PG--TCTLPLAQRITKQICCCSRVGKAWGSE 708
C + +G C S PG C P Q C S +G + G +
Sbjct: 2607 GCQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVSGLGFSPGPQ 2659
Score = 42.0 bits (97), Expect = 0.005
Identities = 27/78 (34%), Positives = 32/78 (41%), Gaps = 17/78 (21%)
Query: 359 ICKQTCARGHCA--NSCERGDTTTLYSQG---GHGHDPKSGFRIYFCQIPCLNGGRCIGR 413
IC++ C G C+ N C D T S G G G C + C+NGG C G
Sbjct: 85 ICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSG-----------CSVSCMNGGTCRGA 133
Query: 414 DECWCPANSTGKFCHLPI 431
C C TG C PI
Sbjct: 134 -SCLCQKGYTGTVCGQPI 150
Score = 42.0 bits (97), Expect = 0.005
Identities = 35/132 (26%), Positives = 49/132 (37%), Gaps = 10/132 (7%)
Query: 143 PRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCS 202
P G + SG + G G + C G+T C +P+C+ C N G C
Sbjct: 110 PSCGVSRGSGCSVSCMNGGTCRGASCL---CQKGYTGTV----CGQPICDRGCHNGGRCI 162
Query: 203 RPQLCVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQP 262
P C C GF G +CE D P ++ P + L + A T+ RA
Sbjct: 163 GPNRCACVYGFMGPQCER---DYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWG 219
Query: 263 PAPQSPPAPQSP 274
+ PA P
Sbjct: 220 LPCELCPAQPHP 231
Score = 34.3 bits (77), Expect = 1.1
Identities = 21/65 (32%), Positives = 25/65 (38%), Gaps = 15/65 (23%)
Query: 363 TCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRCIGRDECWCPANS 422
TC C C++G T T+ Q C C NGGRCIG + C C
Sbjct: 129 TCRGASCL--CQKGYTGTVCGQP-------------ICDRGCHNGGRCIGPNRCACVYGF 173
Query: 423 TGKFC 427
G C
Sbjct: 174 MGPQC 178
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 278 bits (712), Expect = 3e-74
Identities = 325/1125 (28%), Positives = 438/1125 (38%), Gaps = 258/1125 (22%)
Query: 840 LSTPGIDRCA--AGATNV--------CGP------GTCVNLPD-GYRCVCSPGYQLHPSQ 882
L+TPG RC AG T C P GTC D Y C C PG++ Q
Sbjct: 175 LNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFE---GQ 231
Query: 883 AYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQEC-QDINECE-QPGVC 940
+ ++C C G C++ V +Y+C C P +T Q C +D++EC+ QP C
Sbjct: 232 NCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT------GQFCTEDVDECQLQPNAC 285
Query: 941 -SGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECR-----HPGTCPD------------ 982
+GG C NT G + C C G+ + Q+I++C H TC D
Sbjct: 286 HNGGTCFNTLGGHSCVCVNGW--TGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMG 343
Query: 983 ---------GRCVNSP-------------GSYTCLACEEGYRGQSGSC-VDVNEC-LTPG 1018
CV++P G C C G+ G G+C DV+EC +
Sbjct: 344 KTGLLCHLDDACVSNPCHEDAICDTNPVNGRAIC-TCPPGFTG--GACDQDVDECSIGAN 400
Query: 1019 VCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSA 1077
C H G+C N +GSF C C +GY E DV+EC S CL+ G F C
Sbjct: 401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCET---DVNECLSGPCRNQATCLDRIGQFTC-I 456
Query: 1078 CENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-D 1135
C G+ GT CE D+DEC GVC + FSC C G+ G +C+ D
Sbjct: 457 CMAGF----TGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT-CPSGFS----GSTCQLD 507
Query: 1136 VDECEDPQSSCLGG-ECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECL 1193
VDEC + C G +C + Y+C C +GF+ GT+C+ +V++C + HG C+
Sbjct: 508 VDECAS--TPCRNGAKCVDQPDGYECRCAEGFE---GTLCDRNVDDCSPDP--CHHGRCV 560
Query: 1194 NSHGSFFCLCAPGFVSAEGGTSCQD-VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252
+ SF C CAPG+ GT C+ VDEC + GG C++ + C C PS
Sbjct: 561 DGIASFSCACAPGYT----GTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC-----PSG 611
Query: 1253 ESG-EC-VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECAND 1310
+G C V+ID+C +P C C + Y CV CQPGF P + ++I+ECA+
Sbjct: 612 TTGVNCEVNIDDCAS--NP-CTFGVCRDGINRYDCV--CQPGF-TGPLCN-VEINECASS 664
Query: 1311 TMCGSHGFCDNTDGSFRCLCDQGFE---ISPSGWDCVDVNECELMLAVCGAALCENVEGS 1367
CG G C + + FRCLC G P C C +C + G
Sbjct: 665 P-CGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAH--------EPCSHGICYDAPGG 715
Query: 1368 FLCLC--------ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMD------- 1412
F C+C S DA E +P AGG S+ G H P +
Sbjct: 716 FRCVCEPGWSGPRCSQSLARDACES--QPCRAGGTCSSDG-MGFHCTCPPGVQGRQCELL 772
Query: 1413 --CYSGQKGHAP-CSSVLGRNTTQAECCCTQGASW-GDAC----DLCPSEDSAEFSEICP 1464
C H C S G+ C C QG W G C D C IC
Sbjct: 773 SPCTPNPCEHGGRCESAPGQLPV---CSCPQG--WQGPRCQQDVDECAGPAPCGPHGICT 827
Query: 1465 S--GKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDA 1521
+ G G +T G + D ++C P C NG C + V + C C PGF A
Sbjct: 828 NLAGSFSCTCHGGYT-GPSCDQDINDC---DPNPCLNGGSCQDGVGSFSCSCLPGF---A 880
Query: 1522 SHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPL--------TLDLSQQRCMNSTSST 1573
+ D DEC C G C + SF C C P D S C N +
Sbjct: 881 GPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCV 940
Query: 1574 EDLPD------------HDIH-MDICWKK--VTNDVCSEPLRGHRTTYTECC-------- 1610
+ + H H D C + + VCS G R T E
Sbjct: 941 DGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTL 1000
Query: 1611 --------CQDGEAWSQQCA--LCPPRSSEVYAQLCNVARI---EAEREAGVHFRPGYEY 1657
CQ+G Q A LCPP S +LC++ + EA + GV +
Sbjct: 1001 VDWCSRQPCQNGGRCVQTGAYCLCPPGWS---GRLCDIRSLPCREAAAQIGVRLEQLCQA 1057
Query: 1658 GP---GPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRT-PILESPLQPSE 1713
G D HY + P+G T H P L P Q
Sbjct: 1058 GGQCVDEDSSHYCVC-PEG-------------------RTGSHCEQEVDPCLAQPCQHGG 1097
Query: 1714 LQPHYVASHP-EPPAGFEGLQAE----ECGILNGCENGRCVRVREGYTCDCFEGFQLDAA 1768
Y+ + E G+ G E EC G C+ + Y C C G
Sbjct: 1098 TCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPG----TL 1153
Query: 1769 HMACVDVNECDDLNGPAV----LCVH-GYCENTEGSYRCHCSPGY 1808
+ C ++NE D GP + C+H G C + G +RC C PGY
Sbjct: 1154 GVLC-EINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY 1197
Score = 249 bits (635), Expect = 2e-65
Identities = 339/1317 (25%), Positives = 478/1317 (36%), Gaps = 252/1317 (19%)
Query: 403 PCLNGGRCIGRDE----CWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTF 458
PC NGGRC C CP G+ C L P GRG +++ + F
Sbjct: 48 PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTAR---F 104
Query: 459 TLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPAS 518
+ + SL P S A+ G + + + PP
Sbjct: 105 SCRCPRGFRGPDCSLPD------PCLSSPCAHGARCSVGPDGRFLCSC-----PPGYQGR 153
Query: 519 PGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCG 578
S D R GEP R P +C C NP + G
Sbjct: 154 SCRSDVDE----CRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNG 209
Query: 579 SVGAFWG-VTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHC----------------- 620
G +T C P E +CP G++ LN C
Sbjct: 210 GTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP-GHRCLNGGTCVDGVNTYNCQCPPEWTG 268
Query: 621 ----QDINEC-LTLGLCKDA-ECVNTRGSYLCTCRPGLMLDPSRSRCVSD--KAISMLQG 672
+D++EC L C + C NT G + C C G S S+ + D A+
Sbjct: 269 QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG-WTGESCSQNIDDCATAVCFHGA 327
Query: 673 LCYRSLGPGTCTLPLAQRITKQIC----CCSRVGKAWGSECEKCPLPGTEAFREICPAGH 728
C+ + C P+ + T +C C + C+ P+ G R IC
Sbjct: 328 TCHDRVASFYCACPMGK--TGLLCHLDDACVSNPCHEDAICDTNPVNG----RAICTCPP 381
Query: 729 GYTYASSDIRL---SMRKAEEEELARPPREQGQ---RSSGALPGP-AERQPLRVVTDTWL 781
G+T + D + S+ E L R QG + GP E ++
Sbjct: 382 GFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCR 441
Query: 782 EAGTIPDKGDSQAGQVTTSVTHAPAWVTGN--------ATTPPMPEQGIAEIQEEQVTPS 833
T D+ GQ T A TG + P G+ + + + +
Sbjct: 442 NQATCLDR----IGQFTCICM---AGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT 494
Query: 834 TDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECL 892
+ ST +D +T CV+ PDGY C C+ G++ C + ++C
Sbjct: 495 CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFE----GTLCDRNVDDCS 550
Query: 893 RDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSY 952
DPC GRC++ + S+SC C PGYT G E Q ++EC GG+C + Y
Sbjct: 551 PDPCH-HGRCVDGIASFSCACAPGYT----GTRCESQ-VDECRSQPCRHGGKCLDLVDKY 604
Query: 953 HCECDQGYIMVRKGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDV 1011
C C G V +C+ +I++C C G C + Y C+ C+ G+ G + V++
Sbjct: 605 LCRCPSGTTGV---NCEVNIDDCAS-NPCTFGVCRDGINRYDCV-CQPGFTGPLCN-VEI 658
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEG 1071
NEC + G C + E FRC C G S C + C G+C + G
Sbjct: 659 NECASSPCGEGGSCVDGENGFRCLCPPG----SLPPLCLPPSHPCAHEPCSHGICYDAPG 714
Query: 1072 SFACSACENGYWVNEDGTACEDL---DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSP 1128
F C CE G+ G C D C G C++ F C C G +
Sbjct: 715 GFRC-VCEPGW----SGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCT-CPPGVQ--- 765
Query: 1129 LGDSCEDVDECEDPQSSCLGGECKNTVGSYQ-CLCPQGFQLANGTVCE-DVNECMGEEHC 1186
G CE + C P GG C++ G C CPQG+Q G C+ DV+EC G C
Sbjct: 766 -GRQCELLSPCT-PNPCEHGGRCESAPGQLPVCSCPQGWQ---GPRCQQDVDECAGPAPC 820
Query: 1187 APHGECLNSHGSFFCLCAPGFVSAEGGTSC-QDVDECATTDPCV-GGHCVNTEGSFNCLC 1244
PHG C N GSF C C G+ G SC QD+++C +PC+ GG C + GSF+C C
Sbjct: 821 GPHGICTNLAGSFSCTCHGGYT----GPSCDQDINDC-DPNPCLNGGSCQDGVGSFSCSC 875
Query: 1245 ETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG---FHMAPNGDC 1301
GF P D+DEC +P CG C + S+ C C PG FH
Sbjct: 876 LPGFA-GPRCAR--DVDEC--LSNP-CGPGTCTDHVASFTCT--CPPGYGGFHCEQ---- 923
Query: 1302 IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGF-------EISPS--------------- 1339
D+ +C+ + C + G C + SF CLC G+ E P
Sbjct: 924 -DLPDCSPSS-CFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAH 981
Query: 1340 -GWDCVDVN-----ECELMLAVCGAALCEN----VEGSFLCLCASDLEEY--DAQEGHCR 1387
G+ C + +C+ ++ C C+N V+ CLC D + CR
Sbjct: 982 PGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCR 1041
Query: 1388 PRGA------------GGQSMSE----------APTGDHA----------PAPTRMDCYS 1415
A GGQ + E TG H P C
Sbjct: 1042 EAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC-R 1100
Query: 1416 GQKGHAPCSSVLGRNTTQAEC----CCTQGASWGDAC-DLCPSEDSAEFSEICPSGKGYI 1470
G G C + G N E C +Q G +C DL A + CP G
Sbjct: 1101 GYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLV-----ARYLCSCPPG---- 1151
Query: 1471 PVEGAWTFGQTMYTDADEC-----VIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKK 1525
T G + D+C + GP NG C++ V G+ C C PG+ + +
Sbjct: 1152 ------TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLR 1201
Query: 1526 CE-DHDECQDLAC---ENGECV-NTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLP 1577
CE D +EC+ AC +C+ + G F C C S RC S E P
Sbjct: 1202 CEADINECRSGACHAAHTRDCLQDPGGGFRCLCH----AGFSGPRCQTVLSPCESQP 1254
Score = 244 bits (622), Expect = 7e-64
Identities = 282/1020 (27%), Positives = 405/1020 (39%), Gaps = 207/1020 (20%)
Query: 836 VLVTLSTPGIDR--CAAGATNVCGPGTCVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECL 892
+L+ L+ PG C G+ G G C LP C+C PG+ C ++ C
Sbjct: 29 LLLLLAGPGAAAPPCLDGSPCANG-GRCTQLPSREAACLCPPGWV----GERCQLEDPCH 83
Query: 893 RDPCKGKGRCINRV----GSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCT-N 947
PC G+G C + V +SC C G+ +C + C G +C+
Sbjct: 84 SGPCAGRGVCQSSVVAGTARFSCRCPRGF------RGPDCSLPDPCLSSPCAHGARCSVG 137
Query: 948 TEGSYHCECDQGYIMVRKGHCQ-DINECRHPGTC-PDGRCVNSPGSYTCLACEEGYRGQS 1005
+G + C C GY + C+ D++ECR C G C+N+PGS+ C C GY G
Sbjct: 138 PDGRFLCSCPPGY---QGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRC-QCPAGYTGP- 192
Query: 1006 GSCVDVNECLTPGVCAHGKCTNLEG--SFRCSCEQGYEVTSDEKGCQDVDECASRASCPT 1063
C + P C +G G ++ C+C G+E + E +VD+C
Sbjct: 193 -LCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCE---VNVDDCPGHRCLNG 248
Query: 1064 GLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVCPS-GVCTNTAGSFSCKDCD 1121
G C++ ++ C W + T ED+DEC P C + G C NT G SC C
Sbjct: 249 GTCVDGVNTYNCQCPPE--WTGQFCT--EDVDECQLQPNACHNGGTCFNTLGGHSCV-CV 303
Query: 1122 GGYRPSPLGDSC-EDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGFQLANGTVCEDVNE 1179
G+ G+SC +++D+C + C G C + V S+ C CP G G +C +
Sbjct: 304 NGW----TGESCSQNIDDC--ATAVCFHGATCHDRVASFYCACPMG---KTGLLCHLDDA 354
Query: 1180 CMGEEHCAPHGECLNS--HGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPCVG-GHCVN 1235
C+ C C + +G C C PGF GG QDVDEC+ +PC G CVN
Sbjct: 355 CVSNP-CHEDAICDTNPVNGRAICTCPPGFT---GGACDQDVDECSIGANPCEHLGRCVN 410
Query: 1236 TEGSFNCLCETGFQ-PSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294
T+GSF C C G+ P E+ D++EC P C + G + C+ C GF
Sbjct: 411 TQGSFLCQCGRGYTGPRCET----DVNEC--LSGPCRNQATCLDRIGQFTCI--CMAGF- 461
Query: 1295 MAPNGDC-IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELM 1352
C +DIDEC + C + G C + F C C GF SG C +DV+EC
Sbjct: 462 --TGTYCEVDIDEC-QSSPCVNGGVCKDRVNGFSCTCPSGF----SGSTCQLDVDECAST 514
Query: 1353 LAVCGAALCENVEGSFLCLCASDLEE--YDAQEGHCRPRGA-GGQSMSEAPTGDHAPAPT 1409
GA + +G + C CA E D C P G+ + + A AP
Sbjct: 515 PCRNGAKCVDQPDG-YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPG 573
Query: 1410 RMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDAC-DLCPSEDSAEFSEICPSGKG 1468
Y+G + C S Q + C +Q G C DL ++ CPSG
Sbjct: 574 ----YTGTR----CES-------QVDECRSQPCRHGGKCLDLVD-----KYLCRCPSG-- 611
Query: 1469 YIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCE- 1527
T G + D+C C G C + + Y C+C PGF + C
Sbjct: 612 --------TTGVNCEVNIDDC---ASNPCTFGVCRDGINRYDCVCQPGF----TGPLCNV 656
Query: 1528 DHDECQDLAC-ENGECVNTEGSFHCFCS----PPLTLDLSQQRCMNSTSSTEDLPDHDIH 1582
+ +EC C E G CV+ E F C C PPL L P H
Sbjct: 657 EINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP----------------PSHPCA 700
Query: 1583 MDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIE 1642
+ C ++ +C + G R C C+ G WS PR S+ A+ + +
Sbjct: 701 HEPC----SHGICYDAPGGFR-----CVCEPG--WS------GPRCSQSLAR--DACESQ 741
Query: 1643 AEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRT 1702
R G D + + P G G + + P PN H
Sbjct: 742 PCRAGGT---------CSSDGMGFHCTCPPGVQ-----GRQCELLSPCTPNPCEHGG--- 784
Query: 1703 PILESPLQPSELQPHYVASHPEPPAGFEG----LQAEECGILNGC-ENGRCVRVREGYTC 1757
P +L V S P+ G++G +EC C +G C + ++C
Sbjct: 785 ---RCESAPGQLP---VCSCPQ---GWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
Query: 1758 DCFEGFQLDAAHMACVDVNECDD---LNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGP 1814
C G+ + D+N+CD LNG G C++ GS+ C C PG+ AGP
Sbjct: 836 TCHGGYTGPSCDQ---DINDCDPNPCLNG-------GSCQDGVGSFSCSCLPGF---AGP 882
Score = 186 bits (472), Expect = 2e-46
Identities = 239/897 (26%), Positives = 323/897 (36%), Gaps = 142/897 (15%)
Query: 589 CAPCPPRPASPV--IENGQLECPQGYKRLNLTHCQD-INECLTLGLCKDAECVNTRGSYL 645
C+P P V I + C GY T C+ ++EC + +C++ YL
Sbjct: 549 CSPDPCHHGRCVDGIASFSCACAPGYTG---TRCESQVDECRSQPCRHGGKCLDLVDKYL 605
Query: 646 CTC---RPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTC------TLPLAQRITKQIC 696
C C G+ + + C S+ G+C + C T PL + C
Sbjct: 606 CRCPSGTTGVNCEVNIDDCASNPCTF---GVCRDGINRYDCVCQPGFTGPLCN-VEINEC 661
Query: 697 CCSRVGKAWGSECEKCPLPGTEAFREICPAG----------HGYTYASSDIRLSMRKAEE 746
S G+ G C + G FR +CP G H + +
Sbjct: 662 ASSPCGE--GGSC----VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG 715
Query: 747 EELARPPREQGQRSSGALPGPA-ERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAP 805
P G R S +L A E QP R GT G V
Sbjct: 716 FRCVCEPGWSGPRCSQSLARDACESQPCRA-------GGTCSSDGMGFHCTCPPGVQGRQ 768
Query: 806 AWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTP----GIDRCAAGATNVCGP-GT 860
+ T P G E Q+ P P +D CA A CGP G
Sbjct: 769 CELLSPCTPNPCEHGGRCESAPGQL-PVCSCPQGWQGPRCQQDVDECAGPAP--CGPHGI 825
Query: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919
C NL + C C GY PS C D N+C +PC G C + VGS+SC C PG+
Sbjct: 826 CTNLAGSFSCTCHGGYT-GPS---CDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGF-- 879
Query: 920 ATSGATQEC-QDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHC-QDINECRHP 977
A C +D++EC C G CT+ S+ C C GY HC QD+ +C
Sbjct: 880 ----AGPRCARDVDEC-LSNPCGPGTCTDHVASFTCTCPPGY---GGFHCEQDLPDCSPS 931
Query: 978 GTCPDGRCVNSPGSYTCLACEEGYRGQSGSCV-DVNECLTPGVCAHGKCTNLEGSFRCSC 1036
G CV+ S++CL C GY G C + + CL+ G C+ FRC+C
Sbjct: 932 SCFNGGTCVDGVNSFSCL-CRPGYTG--AHCQHEADPCLSRPCLHGGVCSAAHPGFRCTC 988
Query: 1037 EQGYEVTSDEKGCQDVDECASRASCPT-GLCLNTEGSFACSACENGYWVNEDGTACED-- 1093
+ + CQ + + SR C G C+ T C +G + C +
Sbjct: 989 LESFTGPQ----CQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAA 1044
Query: 1094 ------LDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDPQSSC 1146
L++ G G C + S C +G G CE +VD C Q
Sbjct: 1045 AQIGVRLEQLCQAG----GQCVDEDSSHYCVCPEG-----RTGSHCEQEVDPCL-AQPCQ 1094
Query: 1147 LGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFFCLCAP 1205
GG C+ +G Y C C G+ NG CE DV+EC + C G C++ + C C P
Sbjct: 1095 HGGTCRGYMGGYMCECLPGY---NGDNCEDDVDEC-ASQPCQHGGSCIDLVARYLCSCPP 1150
Query: 1206 GFVSAEGGTSCQ-DVDECATTDP------CV-GGHCVNTEGSFNCLCETGFQPSPESGEC 1257
G + G C+ + D+C P C+ G CV+ G F C C G+ C
Sbjct: 1151 GTL----GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGY----TGLRC 1202
Query: 1258 -VDIDECEDYGDPVCGTWKCENSP-GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGS 1315
DI+EC T C P G +RC+ C GF C + C
Sbjct: 1203 EADINECRSGACHAAHTRDCLQDPGGGFRCL--CHAGF---SGPRCQTVLSPCESQPCQH 1257
Query: 1316 HGFCDNTDG-----SFRCLCDQGFEISPSGWDCVDV-NECELMLAVCGAALCENVEGSFL 1369
G C + G +F C C Q F G C V C + G C+
Sbjct: 1258 GGQCRPSPGPGGGLTFTCHCAQPF----WGPRCERVARSCRELQCPVGVP-CQQTPRGPR 1312
Query: 1370 CLCASDLEEYDAQEGHCRPRGAGGQSMSEAPT---GDHAPAPT----RMDCYSGQKG 1419
C C L + P GA S + AP G PAP R C G G
Sbjct: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTG 1369
Score = 140 bits (354), Expect = 9e-33
Identities = 219/911 (24%), Positives = 300/911 (32%), Gaps = 236/911 (25%)
Query: 622 DINECLTLGLCKDAECVNTRGSYLCTCRPG----LMLDPSRSRCVSDKAISMLQGLCYRS 677
+INEC + + CV+ + C C PG L L PS C + G+CY +
Sbjct: 657 EINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHP-CAHEPCS---HGICYDA 712
Query: 678 LGPGTCTL------PLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYT 731
G C P + + C S+ +A G+ C G F CP G
Sbjct: 713 PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGT----CSSDGM-GFHCTCPPG---- 763
Query: 732 YASSDIRLSMRKAEEEELARP-PREQGQRSSGALPG-------PAERQPLRVVTDTWLEA 783
+ R+ E P P E G R A PG P Q R D A
Sbjct: 764 -------VQGRQCELLSPCTPNPCEHGGRCESA-PGQLPVCSCPQGWQGPRCQQDVDECA 815
Query: 784 GTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPS---TDVLVTL 840
G P + T++ + + T P +Q I + D + +
Sbjct: 816 GPAPCGPHG----ICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSF 871
Query: 841 ST---PGI--DRCAAGA----TNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NE 890
S PG RCA +N CGPGTC + + C C PGY +C D +
Sbjct: 872 SCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGY----GGFHCEQDLPD 927
Query: 891 CLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQ-DINECEQPGVCSGGQCTNTE 949
C C G C++ V S+SC C PGYT A CQ + + C GG C+
Sbjct: 928 CSPSSCFNGGTCVDGVNSFSCLCRPGYTGA------HCQHEADPCLSRPCLHGGVCSAAH 981
Query: 950 GSYHCECDQGYI---------MVRKGHCQDINECRHPGT---CPDG-------------- 983
+ C C + + + CQ+ C G CP G
Sbjct: 982 PGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCR 1041
Query: 984 ------------------RCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC 1025
+CV+ S+ C+ C EG G S +V+ CL G C
Sbjct: 1042 EAAAQIGVRLEQLCQAGGQCVDEDSSHYCV-CPEGRTG-SHCEQEVDPCLAQPCQHGGTC 1099
Query: 1026 TNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVN 1085
G + C C GY + E DVDECAS+ G C++ + CS C G
Sbjct: 1100 RGYMGGYMCECLPGYNGDNCE---DDVDECASQPCQHGGSCIDLVARYLCS-CPPGTL-- 1153
Query: 1086 EDGTACE-DLDEC-------AFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DV 1136
G CE + D+C + P +G C + G F C C GY G CE D+
Sbjct: 1154 --GVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCT-CPPGYT----GLRCEADI 1206
Query: 1137 DECEDPQSSCLGGECKNTV----GSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGEC 1192
+EC +C ++ + G ++CLC GF +G C+ V + C G+C
Sbjct: 1207 NECRS--GACHAAHTRDCLQDPGGGFRCLCHAGF---SGPRCQTVLSPCESQPCQHGGQC 1261
Query: 1193 LNSHG-----SFFCLCAPGF--------------VSAEGGTSCQDVDE---CATTDPCVG 1230
S G +F C CA F + G CQ CA G
Sbjct: 1262 RPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSG 1321
Query: 1231 GHCVNTEGS----------------------------FNCLCETGFQPSPESGECVDIDE 1262
C + GS F C C G+ P E
Sbjct: 1322 PSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWT-GPRCEAPAAAPE 1380
Query: 1263 CEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCI----DIDECANDTMCG---S 1315
+ +P C C+ G RC C GDC D C +
Sbjct: 1381 VSE--EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFN 1438
Query: 1316 HGFCDNTDGSFRCL-------------------------------CDQGFEISPSGWDCV 1344
+ CD S CL CDQG GWD +
Sbjct: 1439 NSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGL 1498
Query: 1345 D-VNECELMLA 1354
D +E +LA
Sbjct: 1499 DCASEVPALLA 1509
Score = 57.4 bits (137), Expect = 1e-07
Identities = 112/484 (23%), Positives = 160/484 (33%), Gaps = 103/484 (21%)
Query: 1351 LMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR--PRGAGGQSMSEAPTGDHAPAP 1408
L+LA GAA ++GS C + ++E C P G + E P
Sbjct: 31 LLLAGPGAAAPPCLDGS-PCANGGRCTQLPSREAACLCPPGWVGERCQLEDP-------- 81
Query: 1409 TRMDCYSGQ-KGHAPCSSVLGRNTTQAECCCTQG-----ASWGDACDLCPSEDSAEFSEI 1462
C+SG G C S + T + C C +G S D C P A S +
Sbjct: 82 ----CHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCS-V 136
Query: 1463 CPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDA 1521
P G+ + G++ +D DEC + P C +G CLNT + C C G+
Sbjct: 137 GPDGRFLCSCPPGYQ-GRSCRSDVDECRVGEP--CRHGGTCLNTPGSFRCQCPAGY---- 189
Query: 1522 SHKKCEDHD-ECQDLACENGECVNTEG--SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPD 1578
+ CE+ C C NG G ++ C C P Q C
Sbjct: 190 TGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDCACLP----GFEGQNC------------ 233
Query: 1579 HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNV 1638
++++D C GHR C ++ QC PP E Q C
Sbjct: 234 -EVNVDDC-------------PGHRCLNGGTCVDGVNTYNCQC---PP---EWTGQFCTE 273
Query: 1639 ARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHS 1698
E + + G + + G G + +D F H
Sbjct: 274 DVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI--DDCATAVCFHGATCHD 331
Query: 1699 ADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCE----NGRCVRVREG 1754
+ P+ + L H + P + + C+ NGR +
Sbjct: 332 RVASFYCACPMGKTGLLCHLDDACVSNPCHEDAI----------CDTNPVNGRAI----- 376
Query: 1755 YTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH-GYCENTEGSYRCHCSPGYVAEAG 1813
C C GF A DV+EC P C H G C NT+GS+ C C GY
Sbjct: 377 --CTCPPGFTGGACDQ---DVDECSIGANP---CEHLGRCVNTQGSFLCQCGRGYTG--- 425
Query: 1814 PPHC 1817
P C
Sbjct: 426 -PRC 428
Score = 50.4 bits (119), Expect = 2e-05
Identities = 144/647 (22%), Positives = 212/647 (32%), Gaps = 164/647 (25%)
Query: 163 LTGRNVCGGQCCPGWTTA---NSTNHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGFRGA 216
+ GR +C C PG+T + C + PC++ G C Q LC C G+ G
Sbjct: 371 VNGRAIC--TCPPGFTGGACDQDVDEC--SIGANPCEHLGRCVNTQGSFLCQCGRGYTGP 426
Query: 217 RCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAG-EGTLARAQPPAPQSPPAPQSPP 275
RCE + + P ++ +R AG GT QS P
Sbjct: 427 RCETDVNECLSGPCRNQAT---CLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGV 483
Query: 276 A-GTLSGLSQTHPSQQHVGLS-RTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPL 333
++G S T PS G S T +L AS+ + A ++Q DG +
Sbjct: 484 CKDRVNGFSCTCPS----GFSGSTCQLDVDECASTPCRNGA----KCVDQPDGYECRCAE 535
Query: 334 EHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCAN-------SCERGDTTTLYSQGG 386
+ N+ + C G C + +C G T T
Sbjct: 536 GFEGTLCDRNVDD------------CSPDPCHHGRCVDGIASFSCACAPGYTGT------ 577
Query: 387 HGHDPKSGFRIYFCQI-PCLNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREPPGRG 442
+ ++ C+ PC +GG+C + + C CP+ +TG C + I P G
Sbjct: 578 -----RCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG 632
Query: 443 -SRPRALLEAPLKQSTFTLPLSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEA 501
R + Q FT PL N V+I++ A G +
Sbjct: 633 VCRDGINRYDCVCQPGFTGPLCN---------------------VEINECASSPCGEGGS 671
Query: 502 LV--ENSVETRPPPWLPASPGHSLWDSNNIPARSGEPPRPLPPAAP-------------R 546
V EN PP PP LPP+ P
Sbjct: 672 CVDGENGFRCLCPP-------------------GSLPPLCLPPSHPCAHEPCSHGICYDA 712
Query: 547 PRGLLGRCYLNTVNGQCANPLL-ELTTQEDC-----CGSVGAFWGVT-----------LC 589
P G C +C+ L + + C C S G + T L
Sbjct: 713 PGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELL 772
Query: 590 APCPPRPASP----VIENGQL---ECPQGYKRLNLTHCQDINECLTLGLC-KDAECVNTR 641
+PC P P GQL CPQG++ QD++EC C C N
Sbjct: 773 SPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQ--QDVDECAGPAPCGPHGICTNLA 830
Query: 642 GSYLCTCRPGLMLDPSRSRCVS--DKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCS 699
GS+ CTC G PS + ++ D + G C +G +C+ C
Sbjct: 831 GSFSCTCHGG-YTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCS-----------CLPG 878
Query: 700 RVGKAWGSECEKCPL----PGT-----EAFREICPAGHGYTYASSDI 737
G + ++C PGT +F CP G+G + D+
Sbjct: 879 FAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDL 925
Score = 39.3 bits (90), Expect = 0.035
Identities = 35/118 (29%), Positives = 38/118 (32%), Gaps = 21/118 (17%)
Query: 122 RRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVC--------GGQC 173
RR P+ P P RA P L L P AAPP C C
Sbjct: 10 RRRRPMSPPPPPPPVRALPLLLLLAGP--GAAAPPCLDGSPCANGGRCTQLPSREAACLC 67
Query: 174 CPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQL-------CVCRSGFRGARCEEVIPD 224
PGW P PC RG C + C C GFRG C +PD
Sbjct: 68 PPGWVGERCQLE--DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCS--LPD 121
Score = 37.0 bits (84), Expect = 0.18
Identities = 34/114 (29%), Positives = 44/114 (38%), Gaps = 14/114 (12%)
Query: 115 VQPPAQTRRSTPLGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTGRNVCGGQCC 174
V P + S P G Q + R+ R+G P R G P G C QC
Sbjct: 136 VGPDGRFLCSCPPGYQGRSCRSDVDEC--RVGEPCRHGGTCLNTP-----GSFRC--QCP 186
Query: 175 PGWTTANSTNHCIKPVCEPPCQNRGSCSRP----QLCVCRSGFRGARCEEVIPD 224
G+T N + P PC+N G+C + C C GF G CE + D
Sbjct: 187 AGYTGPLCENPAV-PCAPSPCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDD 239
Score = 36.2 bits (82), Expect = 0.30
Identities = 19/68 (27%), Positives = 28/68 (41%), Gaps = 13/68 (19%)
Query: 170 GGQC----------CPGWTTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGA 216
GGQC CP T + + P PCQ+ G+C +C C G+ G
Sbjct: 1058 GGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGD 1117
Query: 217 RCEEVIPD 224
CE+ + +
Sbjct: 1118 NCEDDVDE 1125
Score = 35.8 bits (81), Expect = 0.39
Identities = 48/166 (28%), Positives = 57/166 (34%), Gaps = 38/166 (22%)
Query: 89 QPGWGSPRRPTEAEARRPSRAQQSRR--------------VQPPAQTRRSTPLGQQQPAP 134
+PGW PR +++ AR +Q R P Q R+ L P P
Sbjct: 721 EPGWSGPRC-SQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
Query: 135 -----RTRAAPA-LPRLGTPQR----------SGAAPPTP--PRGRLTGRNVCGGQCCPG 176
R +AP LP PQ A P P P G T C G
Sbjct: 780 CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHG 839
Query: 177 WTTANSTNHCIKPVCEP-PCQNRGSCS---RPQLCVCRSGFRGARC 218
T S + I C+P PC N GSC C C GF G RC
Sbjct: 840 GYTGPSCDQDIND-CDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRC 884
Score = 35.4 bits (80), Expect = 0.51
Identities = 77/308 (25%), Positives = 100/308 (32%), Gaps = 74/308 (24%)
Query: 173 CCPGWTTANSTNHCIK--PVCEPP-CQNRGSCS---RPQLCVCRSGFRGARCEEVIPDEE 226
C PG+ HC + P C P C N G+C C+CR G+ GA C+
Sbjct: 912 CPPGY----GGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQH------ 961
Query: 227 FDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQP----PAPQSPPAPQSPPAGTLSGL 282
E P L R G G + A P +S PQ TL
Sbjct: 962 --------------EADPCLSRPCLHG-GVCSAAHPGFRCTCLESFTGPQ---CQTLVDW 1003
Query: 283 SQTHPSQQHVGLSRT--VRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPW 340
P Q +T L P + +LP + Q V LE
Sbjct: 1004 CSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPC-----REAAAQIGVRLEQLCQAG 1058
Query: 341 GLNLTEKIKKIKIVFTPTICKQTCARGHC--------ANSCERGDTTTLYSQGGHGHDPK 392
G + E +C + HC A C+ G T Y GG+ +
Sbjct: 1059 GQCVDEDSSHY------CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGY-MGGYMCECL 1111
Query: 393 SGFRIYFCQ--------IPCLNGGRCI---GRDECWCPANSTGKFCHLPIPQPDREP-PG 440
G+ C+ PC +GG CI R C CP + G C I + D P P
Sbjct: 1112 PGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE--INEDDCGPGPP 1169
Query: 441 RGSRPRAL 448
S PR L
Sbjct: 1170 LDSGPRCL 1177
Score = 34.3 bits (77), Expect = 1.1
Identities = 21/64 (32%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRP---QLCVCRSGFRGARCEE 220
G N QC P WT T + +P C N G+C CVC +G+ G C +
Sbjct: 254 GVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQ 313
Query: 221 VIPD 224
I D
Sbjct: 314 NIDD 317
Score = 31.2 bits (69), Expect = 9.6
Identities = 27/93 (29%), Positives = 33/93 (35%), Gaps = 18/93 (19%)
Query: 152 GAAPPTPPRGRLTGRNVC----GG---QCCPGWTTAN---STNHCIKPVCEPP-----CQ 196
G PP R C GG C PG+T N C C Q
Sbjct: 1165 GPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQ 1224
Query: 197 NRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDP 229
+ G R C+C +GF G RC+ V+ E P
Sbjct: 1225 DPGGGFR---CLCHAGFSGPRCQTVLSPCESQP 1254
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 277 bits (709), Expect = 6e-74
Identities = 195/525 (37%), Positives = 253/525 (48%), Gaps = 73/525 (13%)
Query: 887 DDNECLRDPCK-GKGRCINRVGSYSCFCYPGYTLATSGAT-------------------Q 926
D +ECL P + + CIN VGSY C C+PG++L G T
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 927 ECQDI------------NECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINE 973
E + N C+ G C C+ GS C C GY ++ G C+D +E
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCK-QVCSTVGGSAICSCFPGYAIMADGVSCEDQDE 722
Query: 974 CRHPGTCPDGR--CVNSPGSYTC----LACEEGY-RGQSGSCVDVNECLTP-GVCAHGK- 1024
C R CVN+ GS+ C + C +GY CVD+NEC+T C+ G+
Sbjct: 723 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH 782
Query: 1025 CTNLEGSFRC----SCEQGYEVTSDEKGCQDVDECA-SRASCPTG-LCLNTEGSFACSA- 1077
C N GSF C +CE GY + E C+DVDECA +C G LC NT+GSF C A
Sbjct: 783 CVNTLGSFHCYKALTCEPGYALKDGE--CEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 840
Query: 1078 --CENGYWVNEDGTACEDLDEC-AFPGVC-PSGVCTNTAGSFSCKD----CDGGYRPSPL 1129
C +G+ + +G C D++EC + C P C NT GS++C+ C GY S
Sbjct: 841 QRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDD 899
Query: 1130 GDSCEDVDECEDPQSSCLGGE-CKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCA 1187
G C DV+ECE C G+ C N GSY+C C GFQ A G C DVNEC
Sbjct: 900 GTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRL 959
Query: 1188 PHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETG 1247
C N+ GS+ C CA GF+ A G C+DV+EC C N GS+ C C G
Sbjct: 960 CQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQR--CSQECANIYGSYQCYCRQG 1017
Query: 1248 FQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDE 1306
+Q + + C DIDEC +C T++C N PGSY+C + G+ M NG C D+DE
Sbjct: 1018 YQLAEDGHTCTDIDECAQGAGILC-TFRCLNVPGSYQCACP-EQGYTMTANGRSCKDVDE 1075
Query: 1307 CANDT-MCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECE 1350
CA T C C N GSFRCL FE P+ + V +CE
Sbjct: 1076 CALGTHNCSEAETCHNIQGSFRCL---RFECPPN-YVQVSKTKCE 1116
Score = 269 bits (688), Expect = 2e-71
Identities = 197/572 (34%), Positives = 258/572 (45%), Gaps = 87/572 (15%)
Query: 815 PPMPEQGIAEIQE------EQVTPSTDVLVTLSTPGIDR--CAAGATNVCGPGTCVNLPD 866
PP P + E E ++ T+ + S PG D+ C +C C+N
Sbjct: 567 PPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELC-QHLCINTVG 625
Query: 867 GYRCVCSPGYQLHPSQAYCTDDN-----ECLRDP-----------------------CKG 898
Y C C PG+ L C + E ++P CK
Sbjct: 626 SYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD 685
Query: 899 KGRCINRV----GSYSCFCYPGYTLATSGATQECQDINECEQPG-VCSGGQ-CTNTEGSY 952
G C GS C C+PGY + G + C+D +EC CS Q C NT GS+
Sbjct: 686 NGPCKQVCSTVGGSAICSCFPGYAIMADGVS--CEDQDECLMGAHDCSRRQFCVNTLGSF 743
Query: 953 HCE-----CDQGYIMVRKGHCQDINEC-RHPGTCPDG-RCVNSPGSYTC---LACEEGYR 1002
+C C GYI+ C DINEC TC G CVN+ GS+ C L CE GY
Sbjct: 744 YCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA 803
Query: 1003 GQSGSCVDVNEC-LTPGVCAHG-KCTNLEGSFRCS----CEQGYEVTSDEKGCQDVDECA 1056
+ G C DV+EC + C G C N +GSF C C G+ + E C D++EC
Sbjct: 804 LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF-LQDPEGNCVDINECT 862
Query: 1057 SRAS-CPTGL-CLNTEGSFACS----ACENGYWVNEDGTACEDLDECAFPGV--CPSG-V 1107
S + C G C+NT GS+ C C GY ++DGT C D++EC GV C G V
Sbjct: 863 SLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECE-TGVHRCGEGQV 921
Query: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
C N GS+ C DC G++ G C DV+EC C+NT+GSY+C C GF
Sbjct: 922 CHNLPGSYRC-DCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFL 980
Query: 1168 L-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECAT-T 1225
L A+G CEDVNEC + C+ EC N +GS+ C C G+ AE G +C D+DECA
Sbjct: 981 LAADGKRCEDVNECEA-QRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGA 1037
Query: 1226 DPCVGGHCVNTEGSFNCLC-ETGFQPSPESGECVDIDECEDYGDPVCGTWK-CENSPGSY 1283
C+N GS+ C C E G+ + C D+DEC G C + C N GS+
Sbjct: 1038 GILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECA-LGTHNCSEAETCHNIQGSF 1096
Query: 1284 RCV-LGCQPGF-----HMAPNGDCIDIDECAN 1309
RC+ C P + C D EC N
Sbjct: 1097 RCLRFECPPNYVQVSKTKCERTTCHDFLECQN 1128
Score = 247 bits (631), Expect = 7e-65
Identities = 206/645 (31%), Positives = 281/645 (43%), Gaps = 104/645 (16%)
Query: 693 KQICCCSRVG---KAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEE-- 747
KQ C C +G +A G CE P G Y + + LS + EE
Sbjct: 516 KQCCDCCGLGLRVRAEGQSCESNPNLG---------------YPCNHVMLSCCEGEEPLI 560
Query: 748 --ELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDS---QAGQV----- 797
E+ RPP + A R+ L + T+ L D D G++
Sbjct: 561 VPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLC 620
Query: 798 --TTSVTHAPAWV-------------TGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLST 842
T H + G+ P P++ + + QV +T + L
Sbjct: 621 INTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNT---IPLPL 677
Query: 843 PGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECL--RDPCKG 898
P + C GP C + C C PGY + C D +ECL C
Sbjct: 678 PQPNTCKDN-----GPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSR 732
Query: 899 KGRCINRVGSYSC-----FCYPGYTLATSGATQECQDINEC-EQPGVCSGGQ-CTNTEGS 951
+ C+N +GS+ C C GY L A ++C DINEC CS G+ C NT GS
Sbjct: 733 RQFCVNTLGSFYCVNHTVLCADGYIL---NAHRKCVDINECVTDLHTCSRGEHCVNTLGS 789
Query: 952 YHC----ECDQGYIMVRKGHCQDINEC-RHPGTCPDG-RCVNSPGSYTCLA---CEEGY- 1001
+HC C+ GY + + G C+D++EC TC G C N+ GS+ C A C +G+
Sbjct: 790 FHCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFL 848
Query: 1002 RGQSGSCVDVNECLT-PGVCAHG-KCTNLEGSFRCS-----CEQGYEVTSDEKGCQDVDE 1054
+ G+CVD+NEC + C G C N GS+ C C +GY + D C DV+E
Sbjct: 849 QDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNE 908
Query: 1055 CASRA-SCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDEC-AFPGVCPSGVCTNT 1111
C + C G +C N GS+ C C+ G+ + G C D++EC A PG C NT
Sbjct: 909 CETGVHRCGEGQVCHNLPGSYRCD-CKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENT 967
Query: 1112 AGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLA-N 1170
GS+ C C G+ + G CEDV+ECE + S EC N GSYQC C QG+QLA +
Sbjct: 968 LGSYRC-SCASGFLLAADGKRCEDVNECEAQRCS---QECANIYGSYQCYCRQGYQLAED 1023
Query: 1171 GTVCEDVNECMGEEHCAPHGECLNSHGSFFCLC-APGFVSAEGGTSCQDVDECAT-TDPC 1228
G C D++EC CLN GS+ C C G+ G SC+DVDECA T C
Sbjct: 1024 GHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNC 1083
Query: 1229 VGGH-CVNTEGSFNCL---CETGF----QPSPESGECVDIDECED 1265
C N +GSF CL C + + E C D EC++
Sbjct: 1084 SEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQN 1128
Score = 238 bits (607), Expect = 4e-62
Identities = 172/506 (33%), Positives = 228/506 (45%), Gaps = 55/506 (10%)
Query: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
D +EC PG C NT GSYHC C G+ + G CR G P
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRT-----CRPEGHPPQPEAPQE 658
Query: 989 PGSYTCLACEEGYRGQSGSCVDV-----NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVT 1043
P A + + + + + + N C G C C+ + GS CSC GY +
Sbjct: 659 P------ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIM 711
Query: 1044 SDEKGCQDVDECASRA-SCPTG-LCLNTEGSFACS----ACENGYWVNEDGTACEDLDEC 1097
+D C+D DEC A C C+NT GSF C C +GY +N C D++EC
Sbjct: 712 ADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAH-RKCVDINEC 770
Query: 1098 AFP-GVCPSGV-CTNTAGSFSCKD---CDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-C 1151
C G C NT GSF C C+ GY CEDVDEC +C G C
Sbjct: 771 VTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKD--GECEDVDECAMGTHTCQPGFLC 828
Query: 1152 KNTVGSYQCL----CPQGFQLANGTVCEDVNECMG-EEHCAPHGECLNSHGSFFC----- 1201
+NT GS+ C C GF C D+NEC E C P C+N+ GS+ C
Sbjct: 829 QNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 888
Query: 1202 LCAPGFVSAEGGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVD 1259
+CA G+ +++ GT C DV+EC T C G C N GS+ C C+ GFQ C+D
Sbjct: 889 ICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCID 948
Query: 1260 IDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGF 1318
++EC +C CEN+ GSYRC C GF +A +G C D++EC C
Sbjct: 949 VNECWASPGRLC-QHTCENTLGSYRC--SCASGFLLAADGKRCEDVNECEAQR-CSQE-- 1002
Query: 1319 CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEE 1378
C N GS++C C QG++++ G C D++EC + C NV GS+ C C
Sbjct: 1003 CANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYT 1062
Query: 1379 YDAQEGHCR---PRGAGGQSMSEAPT 1401
A C+ G + SEA T
Sbjct: 1063 MTANGRSCKDVDECALGTHNCSEAET 1088
Score = 169 bits (427), Expect = 3e-41
Identities = 170/576 (29%), Positives = 219/576 (38%), Gaps = 118/576 (20%)
Query: 1092 EDLDECAF-PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVD---ECEDPQSSCL 1147
+D DEC PG +C NT GS+ C C G+ G +C + E PQ L
Sbjct: 603 DDQDECLLLPGELCQHLCINTVGSYHCA-CFPGFSLQDDGRTCRPEGHPPQPEAPQEPAL 661
Query: 1148 GGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGF 1207
E + L L C+D C ++ C+ G GS C C PG+
Sbjct: 662 KSEFSQVASNTIPL-----PLPQPNTCKDNGPC--KQVCSTVG------GSAICSCFPGY 708
Query: 1208 VSAEGGTSCQDVDECATTDPCVGGH-------CVNTEGSFNC-----LCETGFQPSPESG 1255
G SC+D DEC +G H CVNT GSF C LC G+ +
Sbjct: 709 AIMADGVSCEDQDECL-----MGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHR- 762
Query: 1256 ECVDIDECEDYGDPVCGTWKCENSPGSYRC--VLGCQPGFHMAPNGDCIDIDECANDTMC 1313
+CVDI+EC C N+ GS+ C L C+PG+ + +G+C D+DECA T
Sbjct: 763 KCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGECEDVDECAMGTHT 821
Query: 1314 GSHGF-CDNTDGSFRCL----CDQGFEISPSGWDCVDVNECELMLAVCGAAL-CENVEGS 1367
GF C NT GSF C C GF P G +CVD+NEC + C C N GS
Sbjct: 822 CQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVGS 880
Query: 1368 FLC-----LCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAP 1422
+ C +CA H G ++E TG H C GQ H
Sbjct: 881 YTCQRNPLICARGY--------HASDDGTKCVDVNECETGVHR-------CGEGQVCHNL 925
Query: 1423 CSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTM 1482
S C C G DA G+G I V W
Sbjct: 926 PGSY--------RCDCKAGFQ-RDAF-----------------GRGCIDVNECWA----- 954
Query: 1483 YTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGEC 1542
PG C NT+ Y C C GF A K+CED +EC+ C EC
Sbjct: 955 ----------SPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ-EC 1003
Query: 1543 VNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDI-CWKKVTNDVCSEPLRG 1601
N GS+ C+C L C T E I C + C+ P +G
Sbjct: 1004 ANIYGSYQCYCRQGYQLAEDGHTC---TDIDECAQGAGILCTFRCLNVPGSYQCACPEQG 1060
Query: 1602 HRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCN 1637
+ T C+D + +CAL SE A+ C+
Sbjct: 1061 YTMTANGRSCKDVD----ECALGTHNCSE--AETCH 1090
Score = 145 bits (366), Expect = 4e-34
Identities = 95/239 (39%), Positives = 118/239 (49%), Gaps = 20/239 (8%)
Query: 845 IDRCAAGATNVCGPG-TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCK-GKGRC 902
++ C G CG G C NLP YRC C G+Q C D NEC P + + C
Sbjct: 906 VNECETGVHR-CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTC 964
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
N +GSY C C G+ LA G + C+D+NECE CS +C N GSY C C QGY +
Sbjct: 965 ENTLGSYRCSCASGFLLAADG--KRCEDVNECEAQR-CS-QECANIYGSYQCYCRQGYQL 1020
Query: 963 VRKGH-CQDINEC-RHPGTCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNEC-LTP 1017
GH C DI+EC + G RC+N PGSY C E+GY SC DV+EC L
Sbjct: 1021 AEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGT 1080
Query: 1018 GVCAHGK-CTNLEGSFRC---SCEQGYEVTSDEK----GCQDVDECASRASCPTGLCLN 1068
C+ + C N++GSFRC C Y S K C D EC + + T LN
Sbjct: 1081 HNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQNSPARITHYQLN 1139
Score = 89.7 bits (221), Expect = 2e-17
Identities = 157/622 (25%), Positives = 228/622 (36%), Gaps = 109/622 (17%)
Query: 1235 NTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH 1294
+T+ C G Q + ++ EC++I E D VC T + + SY C G
Sbjct: 437 STKDLIETCCAAGQQWAIDNDECLEIPE-SGTEDNVCRTAQ-RHCCVSYLQEKSCMAGVL 494
Query: 1295 MAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE----CE 1350
A G+ ++ ND+ CG + D C G + G C C
Sbjct: 495 GAKEGETCGAED--NDS-CGISLYKQCCD-----CCGLGLRVRAEGQSCESNPNLGYPCN 546
Query: 1351 LMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMS---EAPTGDHAPA 1407
++ C CE E + E A AG +++S EA + P
Sbjct: 547 HVMLSC----CEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPG 602
Query: 1408 PTRMDCY--SGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPS 1465
+ +C G+ C + +G C C G S D C E E
Sbjct: 603 DDQDECLLLPGELCQHLCINTVG----SYHCACFPGFSLQDDGRTCRPEGHPPQPEA--- 655
Query: 1466 GKGYIPVEGAWT--FGQTMYTDADECVIFGPGLCP-NGRC---LNTVPGY-VCLCNPGFH 1518
P E A F Q ++ + P C NG C +TV G +C C PG+
Sbjct: 656 -----PQEPALKSEFSQVA-SNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYA 709
Query: 1519 YDASHKKCEDHDECQDLA--CENGE-CVNTEGSFHCFCSPPLTLD----LSQQRCMNSTS 1571
A CED DEC A C + CVNT GSF+C L D + ++C++
Sbjct: 710 IMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINE 769
Query: 1572 STEDLP-----DHDIHM---DICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCAL 1623
DL +H ++ C+K +T EP G+ EC +D + +
Sbjct: 770 CVTDLHTCSRGEHCVNTLGSFHCYKALT----CEP--GYALKDGEC--EDVDECAMGTHT 821
Query: 1624 CPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPE 1683
C P LC + +A G+ P + + +
Sbjct: 822 CQP------GFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVD--------------INEC 861
Query: 1684 DTVPEPAFP-----NTAG-HSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEEC 1737
++ EP P NT G ++ R P++ Y AS G + + EC
Sbjct: 862 TSLSEPCRPGFSCINTVGSYTCQRNPLI--------CARGYHASDD----GTKCVDVNEC 909
Query: 1738 GI-LNGCENGR-CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
++ C G+ C + Y CDC GFQ DA C+DVNEC P LC H CEN
Sbjct: 910 ETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC--WASPGRLCQH-TCEN 966
Query: 1796 TEGSYRCHCSPGYVAEAGPPHC 1817
T GSYRC C+ G++ A C
Sbjct: 967 TLGSYRCSCASGFLLAADGKRC 988
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 1735 EECGILNGCENGRC----VRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790
+ C +N CE RC + Y C C +G+QL C D++EC G +LC
Sbjct: 986 KRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDEC--AQGAGILCTF 1043
Query: 1791 GYCENTEGSYRCHC-SPGYVAEAGPPHC 1817
C N GSY+C C GY A C
Sbjct: 1044 -RCLNVPGSYQCACPEQGYTMTANGRSC 1070
Score = 47.4 bits (111), Expect = 1e-04
Identities = 53/189 (28%), Positives = 66/189 (34%), Gaps = 44/189 (23%)
Query: 519 PGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQED--- 575
PG SL D G PP+P P P + + NT+ PL + T +D
Sbjct: 633 PGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTI----PLPLPQPNTCKDNGP 688
Query: 576 ---CCGSVG------AFWGVTLCAP----------------------CPPRPASPVIENG 604
C +VG F G + A C S N
Sbjct: 689 CKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYCVNH 748
Query: 605 QLECPQGYKRLNLTHCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSR 658
+ C GY C DINEC+T L C E CVNT GS+ C TC PG L
Sbjct: 749 TVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGE 808
Query: 659 SRCVSDKAI 667
V + A+
Sbjct: 809 CEDVDECAM 817
Score = 41.6 bits (96), Expect = 0.007
Identities = 35/139 (25%), Positives = 51/139 (36%), Gaps = 14/139 (10%)
Query: 587 TLCAPCPP------RPASPVIENGQLECPQGYKRLNL-THCQDINECLT-LGLCKDAE-C 637
+L PC P S + L C +GY + T C D+NEC T + C + + C
Sbjct: 863 SLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVC 922
Query: 638 VNTRGSYLCTCRPGLMLDPSRSRCVSDKAI-----SMLQGLCYRSLGPGTCTLPLAQRIT 692
N GSY C C+ G D C+ + Q C +LG C+ +
Sbjct: 923 HNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLA 982
Query: 693 KQICCCSRVGKAWGSECEK 711
C V + C +
Sbjct: 983 ADGKRCEDVNECEAQRCSQ 1001
Score = 41.6 bits (96), Expect = 0.007
Identities = 28/84 (33%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 1737 CGILNGCENG-------RCVRVREGYTCDCFE-GFQLDAAHMACVDVNECDDLNGPAVLC 1788
C ++ C G RC+ V Y C C E G+ + A +C DV+EC G
Sbjct: 1027 CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDEC--ALGTHNCS 1084
Query: 1789 VHGYCENTEGSYRC---HCSPGYV 1809
C N +GS+RC C P YV
Sbjct: 1085 EAETCHNIQGSFRCLRFECPPNYV 1108
Score = 36.6 bits (83), Expect = 0.23
Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 7/72 (9%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGL-----C 674
C+D+NEC + EC N GSY C CR G L C + G+ C
Sbjct: 988 CEDVNECEAQRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRC 1045
Query: 675 YRSLGPGTCTLP 686
G C P
Sbjct: 1046 LNVPGSYQCACP 1057
Score = 35.0 bits (79), Expect = 0.67
Identities = 19/42 (45%), Positives = 22/42 (52%), Gaps = 3/42 (7%)
Query: 622 DINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
D +ECL L LC+ C+NT GSY C C PG L C
Sbjct: 604 DQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTC 644
Score = 34.3 bits (77), Expect = 1.1
Identities = 27/90 (30%), Positives = 38/90 (42%), Gaps = 14/90 (15%)
Query: 606 LECPQGYKRLNLTHCQDINEC-LTLGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS 659
L C GY L C+D++EC + C+ C NT+GS+ C C G + DP
Sbjct: 796 LTCEPGYA-LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDP-EG 853
Query: 660 RCVSDKAISMLQG------LCYRSLGPGTC 683
CV + L C ++G TC
Sbjct: 854 NCVDINECTSLSEPCRPGFSCINTVGSYTC 883
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 262 bits (669), Expect = 3e-69
Identities = 297/1110 (26%), Positives = 435/1110 (39%), Gaps = 248/1110 (22%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDP--CKGKGR 901
ID C N G CV+ + Y C C P + + YCT+D +EC P C+ G
Sbjct: 258 IDDCPGN--NCKNGGACVDGVNTYNCRCPPEW----TGQYCTEDVDECQLMPNACQNGGT 311
Query: 902 CINRVGSYSCFCYPGYTLATSGATQEC-QDINECEQPGVCSGGQCTNTEGSYHCECDQGY 960
C N G Y+C C G+T ++C ++I++C G C + S++CEC G
Sbjct: 312 CHNTHGGYNCVCVNGWT------GEDCSENIDDCASAACFHGATCHDRVASFYCECPHG- 364
Query: 961 IMVRKGHCQDINECRHPGTCPDG-RCVNSP--GSYTCLACEEGYRGQSGSCVDVNEC-LT 1016
R G +N+ C +G C +P G C C GY G + S DV+EC L
Sbjct: 365 ---RTGLLCHLNDACISNPCNEGSNCDTNPVNGKAIC-TCPSGYTGPACS-QDVDECSLG 419
Query: 1017 PGVCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFAC 1075
C H GKC N GSF C C QGY E DV+EC S CL+ G F C
Sbjct: 420 ANPCEHAGKCINTLGSFECQCLQGYTGPRCEI---DVNECVSNPCQNDATCLDQIGEFQC 476
Query: 1076 SACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134
C GY +G CE + DECA +G C + F C +C G+ G C+
Sbjct: 477 -ICMPGY----EGVHCEVNTDECASSPCLHNGRCLDKINEFQC-ECPTGFT----GHLCQ 526
Query: 1135 -DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGEC 1192
DVDEC G +C + +Y C+C +G+ GT CE D++EC + +G C
Sbjct: 527 YDVDECASTPCKN-GAKCLDGPNTYTCVCTEGY---TGTHCEVDIDEC--DPDPCHYGSC 580
Query: 1193 LNSHGSFFCLCAPGFVS---------------AEGGTSCQD------------------- 1218
+ +F CLC PG+ GGT CQD
Sbjct: 581 KDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGT-CQDRDNAYLCFCLKGTTGPNCE 639
Query: 1219 --VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKC 1276
+D+CA++ PC G C++ + C CE G+ S + ++IDEC G+P C
Sbjct: 640 INLDDCASS-PCDSGTCLDKIDGYECACEPGYTGSMCN---INIDECA--GNPCHNGGTC 693
Query: 1277 ENSPGSYRCVLGCQPGFHMAPNGDCI-DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFE 1335
E+ + C C G+H + C+ +++EC N C HG C ++ ++C CD G+
Sbjct: 694 EDGINGFTC--RCPEGYH---DPTCLSEVNEC-NSNPC-VHGACRDSLNGYKCDCDPGW- 745
Query: 1336 ISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQ 1394
SG +C ++ NECE V G C+++ ++C C +EG P
Sbjct: 746 ---SGTNCDINNNECESNPCVNGGT-CKDMTSGYVCTC---------REGFSGPNCQ--T 790
Query: 1395 SMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC----CCTQGASWGDACDL 1450
+++E + T +D +G K C+ +L E C G C
Sbjct: 791 NINECASNPCLNQGTCIDDVAGYK----CNCLLPYTGATCEVVLAPCAPSPCRNGGECR- 845
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGR-CLNTVPGY 1509
SED FS +CP+G W GQT D +EC + P C +G C NT GY
Sbjct: 846 -QSEDYESFSCVCPTG---------WQ-GQTCEVDINEC-VLSP--CRHGASCQNTHGGY 891
Query: 1510 VCLCNPGFHY--------DASHKKC---------------------------EDHDECQD 1534
C C G+ D C ED +EC
Sbjct: 892 RCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECAS 951
Query: 1535 LACENG-ECVNTEGSFHCFCSPPL--------TLDLSQQRCMNSTSSTEDLPD------- 1578
C NG C + S+ C C T D ++ C N + + +
Sbjct: 952 DPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPP 1011
Query: 1579 --------HDIHMDICWKKVTNDVCSEPLRGHRTT----YTECCCQD------------- 1613
HD++ + C + +R T YT CQ+
Sbjct: 1012 GFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNG 1071
Query: 1614 GEAW---SQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYG 1670
G+ W +Q CP + +Y + +V+ A + GV ++G D + +
Sbjct: 1072 GKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHC 1131
Query: 1671 PDGAPFYNYLGP--EDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHP-EPPA 1727
A Y G ED V E + SP Q Y+ + + A
Sbjct: 1132 RCQA---GYTGSYCEDLVDECS---------------PSPCQNGATCTDYLGGYSCKCVA 1173
Query: 1728 GFEGL----QAEECGILNGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLN 1782
G+ G+ + +EC + + C+NG C+ + Y C C G Q + D N D
Sbjct: 1174 GYHGVNCSEEIDEC-LSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPV 1232
Query: 1783 GPAVLCVH-GYCENTEGSYRCHCSPGYVAE 1811
+ C + G C + G Y C C PG+V E
Sbjct: 1233 SRSPKCFNNGTCVDQVGGYSCTCPPGFVGE 1262
Score = 256 bits (655), Expect = 1e-67
Identities = 318/1250 (25%), Positives = 472/1250 (37%), Gaps = 252/1250 (20%)
Query: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSR---SRCVSD 664
CP G+ + CQ + C + +C+ SY+C C P R + C
Sbjct: 129 CPPGWSGKS---CQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQK 185
Query: 665 KAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREIC 724
+ G C+ +G C +C + G CE+ +P + +
Sbjct: 186 PGLCRHGGTCHNEVGSYRC-----------VCRATHT----GPNCERPYVPCSPS----- 225
Query: 725 PAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAG 784
P +G T P LPG + + D G
Sbjct: 226 PCQNGGTCR-------------------PTGDVTHECACLPGFTGQNCEENIDDC---PG 263
Query: 785 TIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPG 844
G + V T P TG T ++ E Q+ P+
Sbjct: 264 NNCKNGGACVDGVNTYNCRCPPEWTGQYCT--------EDVDECQLMPNA---------- 305
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGKGRCI 903
C G GTC N GY CVC G+ + C+++ ++C C C
Sbjct: 306 ---CQNG-------GTCHNTHGGYNCVCVNGW----TGEDCSENIDDCASAACFHGATCH 351
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTN-TEGSYHCECDQGYIM 962
+RV S+ C C G T C N C + C TN G C C GY
Sbjct: 352 DRVASFYCECPHGRTGLLCHLNDACIS-NPCNEGSNCD----TNPVNGKAICTCPSGY-- 404
Query: 963 VRKGHCQDINECRHPGTCP---DGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGV 1019
QD++EC G P G+C+N+ GS+ C C +GY G +DVNEC++
Sbjct: 405 TGPACSQDVDEC-SLGANPCEHAGKCINTLGSFEC-QCLQGYTGPRCE-IDVNECVSNPC 461
Query: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079
C + G F+C C GYE E + DECAS G CL+ F C C
Sbjct: 462 QNDATCLDQIGEFQCICMPGYEGVHCE---VNTDECASSPCLHNGRCLDKINEFQCE-CP 517
Query: 1080 NGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVD 1137
G+ G C+ D+DECA C + +++C C GY G CE D+D
Sbjct: 518 TGF----TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCV-CTEGY----TGTHCEVDID 568
Query: 1138 ECE-DPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNS 1195
EC+ DP C G CK+ V ++ CLC G+ G CE ++NEC + C G C +
Sbjct: 569 ECDPDP---CHYGSCKDGVATFTCLCRPGY---TGHHCETNINEC-SSQPCRHGGTCQDR 621
Query: 1196 HGSFFCLCAPGFVSAEGGTSCQ-DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPES 1254
++ C C G G +C+ ++D+CA++ PC G C++ + C CE G+ S +
Sbjct: 622 DNAYLCFCLKGTT----GPNCEINLDDCASS-PCDSGTCLDKIDGYECACEPGYTGSMCN 676
Query: 1255 GECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCI-DIDECANDTMC 1313
++IDEC G+P CE+ + C C G+H + C+ +++EC N C
Sbjct: 677 ---INIDECA--GNPCHNGGTCEDGINGFTC--RCPEGYH---DPTCLSEVNEC-NSNPC 725
Query: 1314 GSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLC 1372
HG C ++ ++C CD G+ SG +C ++ NECE V G C+++ ++C C
Sbjct: 726 -VHGACRDSLNGYKCDCDPGW----SGTNCDINNNECESNPCVNGGT-CKDMTSGYVCTC 779
Query: 1373 ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
+EG P +++E + T +D +G K C+ +L
Sbjct: 780 ---------REGFSGPNCQ--TNINECASNPCLNQGTCIDDVAGYK----CNCLLPYTGA 824
Query: 1433 QAEC----CCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADE 1488
E C G C SED FS +CP+G W GQT D +E
Sbjct: 825 TCEVVLAPCAPSPCRNGGECR--QSEDYESFSCVCPTG---------WQ-GQTCEVDINE 872
Query: 1489 CVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACEN-GECVNT 1545
CV+ C +G C NT GY C C G+ S + CE D D+C+ C N G C +
Sbjct: 873 CVL---SPCRHGASCQNTHGGYRCHCQAGY----SGRNCETDIDDCRPNPCHNGGSCTDG 925
Query: 1546 EGSFHCFCSPPL--------TLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSE 1597
+ C C P + + C N + T+ + D + C + C
Sbjct: 926 INTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCV---DSYTCTCPAGFSGIHC-- 980
Query: 1598 PLRGHRTTYTECCCQDG----EAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRP 1653
+ TE C +G + + LCPP + Y C E + + +H
Sbjct: 981 --ENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSY---CQHDVNECDSQPCLHGGT 1035
Query: 1654 GYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSE 1713
+ G G Y P G Y GP H D +P +
Sbjct: 1036 CQD-GCG----SYRCTCPQG-----YTGPN--------CQNLVHWCDSSPCKNG----GK 1073
Query: 1714 LQPHYVASHPEPPAGFEGL-------------QAEECGILNGCEN-GRCVRVREGYTCDC 1759
+ E P+G+ GL Q + + C++ G CV + C C
Sbjct: 1074 CWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRC 1133
Query: 1760 FEGFQLDAAHMACVD-VNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
G+ C D V+EC P+ C + G Y C C GY
Sbjct: 1134 QAGY----TGSYCEDLVDEC----SPSPCQNGATCTDYLGGYSCKCVAGY 1175
Score = 254 bits (648), Expect = 7e-67
Identities = 290/1089 (26%), Positives = 414/1089 (38%), Gaps = 256/1089 (23%)
Query: 868 YRCVCSPGYQLHPSQAYCTD--DNECLRDPCKGKGRC-INRVGSYSCFCYPGYTLATSGA 924
Y C C+ G+ S C DN CL +PC+ G C + + Y C C PG++
Sbjct: 85 YACSCALGF----SGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWS------ 134
Query: 925 TQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHC-QDINEC-RHPGTC-P 981
+ CQ + C +GGQC E SY C C + C QD+NEC + PG C
Sbjct: 135 GKSCQQADPCASNPCANGGQCLPFEASYICHCPPSF---HGPTCRQDVNECGQKPGLCRH 191
Query: 982 DGRCVNSPGSYTCL--------------------------------------ACEEGYRG 1003
G C N GSY C+ AC G+ G
Sbjct: 192 GGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTG 251
Query: 1004 QS----------------GSCV---------------------DVNEC-LTPGVCAH-GK 1024
Q+ G+CV DV+EC L P C + G
Sbjct: 252 QNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGT 311
Query: 1025 CTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWV 1084
C N G + C C G+ + E +++D+CAS A C + SF C C +G
Sbjct: 312 CHNTHGGYNCVCVNGW---TGEDCSENIDDCASAACFHGATCHDRVASFYCE-CPHG--- 364
Query: 1085 NEDGTACEDLDECAFPGVCPSGVC-TNTAGSFSCKDCDGGYRPSPLGDSC-EDVDECEDP 1142
G C D C C TN + C GY G +C +DVDEC
Sbjct: 365 -RTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGY----TGPACSQDVDECSLG 419
Query: 1143 QSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFF 1200
+ C G+C NT+GS++C C QG+ G CE DVNEC+ C CL+ G F
Sbjct: 420 ANPCEHAGKCINTLGSFECQCLQGY---TGPRCEIDVNECVSNP-CQNDATCLDQIGEFQ 475
Query: 1201 CLCAPGFVSAEGGTSCQ-DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQPSPESGEC- 1257
C+C PG+ G C+ + DECA++ PC+ G C++ F C C TGF +G
Sbjct: 476 CICMPGY----EGVHCEVNTDECASS-PCLHNGRCLDKINEFQCECPTGF-----TGHLC 525
Query: 1258 -VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDC-IDIDECANDTMCGS 1315
D+DEC P KC + P +Y CV C G+ C +DIDEC D
Sbjct: 526 QYDVDECA--STPCKNGAKCLDGPNTYTCV--CTEGY---TGTHCEVDIDECDPDPC--H 576
Query: 1316 HGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
+G C + +F CLC G+ +G C ++NEC G C++ + ++LC C
Sbjct: 577 YGSCKDGVATFTCLCRPGY----TGHHCETNINECSSQPCRHGGT-CQDRDNAYLCFCL- 630
Query: 1375 DLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQA 1434
+G G + E D A +P C SG C +
Sbjct: 631 --------------KGTTGPN-CEINLDDCASSP----CDSG-----TCLDKI----DGY 662
Query: 1435 ECCCTQGASWGDACDL---------CPSEDSAE-----FSEICPSGKGYIPVEGAWTFGQ 1480
EC C G + G C++ C + + E F+ CP G
Sbjct: 663 ECACEPGYT-GSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEG----------YHDP 711
Query: 1481 TMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACEN 1539
T ++ +EC C +G C +++ GY C C+PG+ S C+ +++EC+ C N
Sbjct: 712 TCLSEVNEC---NSNPCVHGACRDSLNGYKCDCDPGW----SGTNCDINNNECESNPCVN 764
Query: 1540 -GECVNTEGSFHCFC-----SPPLTLDLSQ---QRCMNSTSSTEDLPDHDIHMDICWKKV 1590
G C + + C C P ++++ C+N + +D+ + + + +
Sbjct: 765 GGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGA 824
Query: 1591 TNDVCSEPL------RGHRTTYTE------CCCQDGEAWSQQCALCPPRSSEVYAQLCNV 1638
T +V P G +E C C G W Q C +E C
Sbjct: 825 TCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTG--WQGQ--TCEVDINECVLSPCRH 880
Query: 1639 ARIEAEREAG--VHFRPGYEYGPGPDDLHYSIYGP--DGAPFYNYLGPEDTVPEPAFPNT 1694
G H + GY D+ P +G + + P F T
Sbjct: 881 GASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGT 940
Query: 1695 AGHSADRTPILESPLQPSELQPHYVASHP-EPPAGFEGLQAE----ECGILNGCENGRCV 1749
D P + V S+ PAGF G+ E +C + G CV
Sbjct: 941 FCEE-DINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCV 999
Query: 1750 RVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH-GYCENTEGSYRCHCSPGY 1808
+TC C GF DVNECD + C+H G C++ GSYRC C GY
Sbjct: 1000 DGINSFTCLCPPGF---TGSYCQHDVNECD-----SQPCLHGGTCQDGCGSYRCTCPQGY 1051
Query: 1809 VAEAGPPHC 1817
P+C
Sbjct: 1052 TG----PNC 1056
Score = 249 bits (637), Expect = 1e-65
Identities = 274/1013 (27%), Positives = 393/1013 (38%), Gaps = 164/1013 (16%)
Query: 598 SPVIENGQLECPQGYKRLNLTHCQDINEC-LTLGLCKDA-ECVNTRGSYLCTCRPGLM-- 653
+PV CP GY + QD++EC L C+ A +C+NT GS+ C C G
Sbjct: 390 NPVNGKAICTCPSGYTGPACS--QDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGP 447
Query: 654 -LDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSEC--- 709
+ + CVS+ + C +G C + + + C + S C
Sbjct: 448 RCEIDVNECVSNPCQN--DATCLDQIGEFQC---ICMPGYEGVHCEVNTDECASSPCLHN 502
Query: 710 EKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAE 769
+C L F+ CP G D+ +E A P + G + L GP
Sbjct: 503 GRC-LDKINEFQCECPTGFTGHLCQYDV---------DECASTPCKNGAK---CLDGPNT 549
Query: 770 RQPLRV--VTDTWLEAGTI---PDK---GDSQAGQVTTSVTHAPAWVTGNATT-----PP 816
+ T T E PD G + G T + P + + T
Sbjct: 550 YTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSS 609
Query: 817 MPEQGIAEIQEEQVTPSTDVLVTLSTPG----IDRCAAGATNVCGPGTCVNLPDGYRCVC 872
P + Q+ L + P +D CA+ C GTC++ DGY C C
Sbjct: 610 QPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSP---CDSGTCLDKIDGYECAC 666
Query: 873 SPGYQLHPSQAYCTDD-NECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDI 931
PGY + + C + +EC +PC G C + + ++C C GY T ++
Sbjct: 667 EPGY----TGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTC-----LSEV 717
Query: 932 NECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDIN--ECRHPGTCPDGRCVNSP 989
NEC C G C ++ Y C+CD G+ G DIN EC G C +
Sbjct: 718 NECNS-NPCVHGACRDSLNGYKCDCDPGW----SGTNCDINNNECESNPCVNGGTCKDMT 772
Query: 990 GSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGC 1049
Y C C EG+ G + ++NEC + G C + ++C+C Y + C
Sbjct: 773 SGYVC-TCREGFSGPNCQ-TNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGAT----C 826
Query: 1050 QDV-DECASRASCPTGLCLNTEG--SFACSACENGYWVNEDGTACE-DLDECAFPGVCPS 1105
+ V CA G C +E SF+C C G+ G CE D++EC
Sbjct: 827 EVVLAPCAPSPCRNGGECRQSEDYESFSC-VCPTGW----QGQTCEVDINECVLSPCRHG 881
Query: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDPQSSCLGGECKNTVGSYQCLCPQ 1164
C NT G + C C GY G +CE D+D+C P GG C + + + C C
Sbjct: 882 ASCQNTHGGYRCH-CQAGYS----GRNCETDIDDCR-PNPCHNGGSCTDGINTAFCDCLP 935
Query: 1165 GFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECA 1223
GF+ GT CE D+NEC + C C + S+ C C GF G C++
Sbjct: 936 GFR---GTFCEEDINECASDP-CRNGANCTDCVDSYTCTCPAGF----SGIHCENNTPDC 987
Query: 1224 TTDPCV-GGHCVNTEGSFNCLCETGFQPSPESGECV-DIDECEDYGDPVCGTWKCENSPG 1281
T C GG CV+ SF CLC GF S C D++EC+ P C++ G
Sbjct: 988 TESSCFNGGTCVDGINSFTCLCPPGFTGS----YCQHDVNECDS--QPCLHGGTCQDGCG 1041
Query: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGW 1341
SYRC C G+ PN C ++ + + C + G C T +RC C PSGW
Sbjct: 1042 SYRCT--CPQGY-TGPN--CQNLVHWCDSSPCKNGGKCWQTHTQYRCEC-------PSGW 1089
Query: 1342 D---C-VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMS 1397
C V CE+ G + + LC+ A + HCR + S
Sbjct: 1090 TGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTH-------HCRCQAGYTGSYC 1142
Query: 1398 EAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSA 1457
E + +P+P C +G A C+ LG + C C G + C E
Sbjct: 1143 EDLVDECSPSP----CQNG----ATCTDYLGGYS----CKCVAGYHGVN----CSEEIDE 1186
Query: 1458 EFSEICPSGKGYIPVEGAW-------TFGQTMYTDADEC------VIFGPGLCPNGRCLN 1504
S C +G + + + T G + D+C V P NG C++
Sbjct: 1187 CLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVD 1246
Query: 1505 TVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACE---NGECVNTEGSFHCFC 1553
V GY C C PGF ++CE D +EC C+ CV FHC C
Sbjct: 1247 QVGGYSCTCPPGF----VGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCEC 1295
Score = 244 bits (624), Expect = 4e-64
Identities = 293/1137 (25%), Positives = 407/1137 (35%), Gaps = 262/1137 (23%)
Query: 853 TNVC-GPGTCVNLP-DGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYS 910
TN C GTC L Y+C C PG+ S C + C +PC G+C+ SY
Sbjct: 108 TNPCRNGGTCDLLTLTEYKCRCPPGW----SGKSCQQADPCASNPCANGGQCLPFEASYI 163
Query: 911 CFCYPGYTLATSGATQECQDINECEQ-PGVCS-GGQCTNTEGSYHC---------ECDQG 959
C C P + T QD+NEC Q PG+C GG C N GSY C C++
Sbjct: 164 CHCPPSFHGPTCR-----QDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERP 218
Query: 960 YIMVRKGHCQDINECRHPGT----------------------CPD------GRCVNSPGS 991
Y+ CQ+ CR G CP G CV+ +
Sbjct: 219 YVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNT 278
Query: 992 YTCLACEEGYRGQSGSCVDVNEC-LTPGVCAHG-KCTNLEGSFRCSCEQGYEVTSDEKGC 1049
Y C C + GQ + DV+EC L P C +G C N G + C C G+ + E
Sbjct: 279 YNC-RCPPEWTGQYCT-EDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGW---TGEDCS 333
Query: 1050 QDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVC- 1108
+++D+CAS A C + SF C C +G G C D C C
Sbjct: 334 ENIDDCASAACFHGATCHDRVASFYCE-CPHG----RTGLLCHLNDACISNPCNEGSNCD 388
Query: 1109 TNTAGSFSCKDCDGGYRPSPLGDSC-EDVDECEDPQSSCL-GGECKNTVGSYQCLCPQGF 1166
TN + C GY G +C +DVDEC + C G+C NT+GS++C C QG+
Sbjct: 389 TNPVNGKAICTCPSGYT----GPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY 444
Query: 1167 QLANGTVCE-DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ-DVDECAT 1224
G CE DVNEC+ C CL+ G F C+C PG+ G C+ + DECA+
Sbjct: 445 ---TGPRCEIDVNECVSNP-CQNDATCLDQIGEFQCICMPGYE----GVHCEVNTDECAS 496
Query: 1225 TDPCV-GGHCVNTEGSFNCLCETGFQPSPESGECV--DIDECEDYGDPVCGTWKCENSPG 1281
+ PC+ G C++ F C C TGF +G D+DEC P KC + P
Sbjct: 497 S-PCLHNGRCLDKINEFQCECPTGF-----TGHLCQYDVDECAS--TPCKNGAKCLDGPN 548
Query: 1282 SYRCVLGCQPGFHMAPNGDC-IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSG 1340
+Y CV C G+ C +DIDEC D +G C + +F CLC G+ +G
Sbjct: 549 TYTCV--CTEGY---TGTHCEVDIDECDPDPC--HYGSCKDGVATFTCLCRPGY----TG 597
Query: 1341 WDC-VDVNECELMLAVCGAALCENVEGSFLCLCASD-----------------------L 1376
C ++NEC G C++ + ++LC C L
Sbjct: 598 HHCETNINECSSQPCRHGGT-CQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCL 656
Query: 1377 EEYDAQEGHCRPRGAGGQS-------------------------MSEAPTGDHAPAPTRM 1411
++ D E C P G P G H P
Sbjct: 657 DKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSE 716
Query: 1412 --DCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL----CPSEDSAEFSEICPS 1465
+C S H C L +C C G S G CD+ C S
Sbjct: 717 VNECNSNPCVHGACRDSLNGY----KCDCDPGWS-GTNCDINNNECESNPCVNGGTCKDM 771
Query: 1466 GKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPN-GRCLNTVPGYVCLC----------- 1513
GY+ G T+ +EC C N G C++ V GY C C
Sbjct: 772 TSGYVCTCREGFSGPNCQTNINECA---SNPCLNQGTCIDDVAGYKCNCLLPYTGATCEV 828
Query: 1514 ----------------NPGFHYDA---------SHKKCE-DHDECQDLACENG-ECVNTE 1546
Y++ + CE D +EC C +G C NT
Sbjct: 829 VLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTH 888
Query: 1547 GSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTY 1606
G + C C S + C P H+ C + C + L G R T+
Sbjct: 889 GGYRCHCQA----GYSGRNCETDIDDCRPNPCHN--GGSCTDGINTAFC-DCLPGFRGTF 941
Query: 1607 TEC----CCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPD 1662
E C D C C + Y C +G+H PD
Sbjct: 942 CEEDINECASDPCRNGANCTDCV----DSYTCTCPAGF------SGIHCENNT-----PD 986
Query: 1663 DLHYSIYGP----DGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHY 1718
S + DG + L P P F + + L Q
Sbjct: 987 CTESSCFNGGTCVDGINSFTCLCP------PGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040
Query: 1719 VASHPEPPAGFEGLQAEECGILNGCEN------GRCVRVREGYTCDC---FEGFQLDAAH 1769
+ P G+ G + +++ C++ G+C + Y C+C + G D
Sbjct: 1041 GSYRCTCPQGYTGPNCQN--LVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPS 1098
Query: 1770 MACVDVNECDDLNGPAVLCVHG-YCENTEGSYRCHCSPGY--------VAEAGPPHC 1817
++C + ++ A LC HG C + ++ C C GY V E P C
Sbjct: 1099 VSCEVAAQRQGVD-VARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPC 1154
Score = 231 bits (590), Expect = 4e-60
Identities = 240/952 (25%), Positives = 357/952 (37%), Gaps = 259/952 (27%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
+D C+ GA G C+N + C C GY + D NEC+ +PC+ C++
Sbjct: 413 VDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEI---DVNECVSNPCQNDATCLD 469
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
++G + C C PGY G E + +EC G+C + + CEC G+
Sbjct: 470 QIGEFQCICMPGY----EGVHCEV-NTDECASSPCLHNGRCLDKINEFQCECPTGFT--- 521
Query: 965 KGH-CQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAH 1022
GH CQ D++EC +C++ P +YTC+ C EGY G VD++EC P C +
Sbjct: 522 -GHLCQYDVDECASTPCKNGAKCLDGPNTYTCV-CTEGYTGTHCE-VDIDEC-DPDPCHY 577
Query: 1023 GKCTNLEGSFRCSCEQGY-----EVTSDEKG---------CQD----------------- 1051
G C + +F C C GY E +E CQD
Sbjct: 578 GSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPN 637
Query: 1052 ----VDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACE-DLDECAFPGVCPSG 1106
+D+CAS + C +G CL+ + C ACE GY G+ C ++DECA G
Sbjct: 638 CEINLDDCAS-SPCDSGTCLDKIDGYEC-ACEPGY----TGSMCNINIDECAGNPCHNGG 691
Query: 1107 VCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGF 1166
C + F+C+ +G + P+ L + V+EC + C+ G C++++ Y+C C G+
Sbjct: 692 TCEDGINGFTCRCPEGYHDPTCLSE----VNECNS--NPCVHGACRDSLNGYKCDCDPGW 745
Query: 1167 QLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ-DVDECATT 1225
+GT C+ N C G C + + C C GF G +CQ +++ECA+
Sbjct: 746 ---SGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGF----SGPNCQTNINECAS- 797
Query: 1226 DPCV---------------------------------------GGHCVNTEG--SFNCLC 1244
+PC+ GG C +E SF+C+C
Sbjct: 798 NPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVC 857
Query: 1245 ETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF----------- 1293
TG+Q G+ ++D E P C+N+ G YRC CQ G+
Sbjct: 858 PTGWQ-----GQTCEVDINECVLSPCRHGASCQNTHGGYRC--HCQAGYSGRNCETDIDD 910
Query: 1294 ---HMAPNG------------DCI----------DIDECANDTMCGSHGFCDNTDGSFRC 1328
+ NG DC+ DI+ECA+D C + C + S+ C
Sbjct: 911 CRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDP-CRNGANCTDCVDSYTC 969
Query: 1329 LCDQGFEISPSGWDCVDVNECELMLAVC-GAALCENVEGSFLCLCASDLE----EYDAQE 1383
C GF SG C + N + + C C + SF CLC ++D E
Sbjct: 970 TCPAGF----SGIHCEN-NTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNE 1024
Query: 1384 GHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG-----------HAPCSS--VLGRN 1430
+P GG T R C G G +PC + +
Sbjct: 1025 CDSQPCLHGG-------TCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQT 1077
Query: 1431 TTQAECCCTQGASW------GDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFG---QT 1481
TQ C C G + +C++ + + +C G + V+ T Q
Sbjct: 1078 HTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGG--LCVDAGNTHHCRCQA 1135
Query: 1482 MYTDA------DECVIFGPGLCPNGR-CLNTVPGYVCLCNPGFHY--------DASHKKC 1526
YT + DEC P C NG C + + GY C C G+H + C
Sbjct: 1136 GYTGSYCEDLVDEC---SPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPC 1192
Query: 1527 EDHDECQDLA---------------CE---------------------NGECVNTEGSFH 1550
++ C DL CE NG CV+ G +
Sbjct: 1193 QNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYS 1252
Query: 1551 CFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGH 1602
C C P +RC + P C ++V ND E GH
Sbjct: 1253 CTCPPGFV----GERCEGDVNECLSNPCDARGTQNCVQRV-NDFHCECRAGH 1299
Score = 186 bits (473), Expect = 1e-46
Identities = 157/541 (29%), Positives = 222/541 (41%), Gaps = 77/541 (14%)
Query: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919
+C N GYRC C GY + TD ++C +PC G C + + + C C PG+
Sbjct: 883 SCQNTHGGYRCHCQAGYSGRNCE---TDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFR- 938
Query: 920 ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDIN-ECRHPG 978
G E +DINEC +G CT+ SY C C G+ + HC++ +C
Sbjct: 939 ---GTFCE-EDINECASDPCRNGANCTDCVDSYTCTCPAGFSGI---HCENNTPDCTESS 991
Query: 979 TCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQ 1038
G CV+ S+TCL C G+ G S DVNEC + G C + GS+RC+C Q
Sbjct: 992 CFNGGTCVDGINSFTCL-CPPGFTG-SYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQ 1049
Query: 1039 GYEVTSDEKGCQDVDECASRASCPTG-LCLNTEGSFACSACENGY---WVNEDGTACEDL 1094
GY + CQ++ + C G C T + C C +G+ + + +CE
Sbjct: 1050 GYTGPN----CQNLVHWCDSSPCKNGGKCWQTHTQYRCE-CPSGWTGLYCDVPSVSCEVA 1104
Query: 1095 DECAFPGVCP----SGVCTNTAGSFSCKDCDGGYRPSPLGDSCED-VDECEDPQSSCLGG 1149
+ V G+C + + C+ C GY G CED VDEC P G
Sbjct: 1105 AQRQGVDVARLCQHGGLCVDAGNTHHCR-CQAGYT----GSYCEDLVDECS-PSPCQNGA 1158
Query: 1150 ECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVS 1209
C + +G Y C C G+ N + E+++EC+ C G CL+ ++ C C G
Sbjct: 1159 TCTDYLGGYSCKCVAGYHGVNCS--EEIDECLSHP-CQNGGTCLDLPNTYKCSCPRG--- 1212
Query: 1210 AEGGTSCQ-DVDEC-ATTDPCV-------GGHCVNTEGSFNCLCETGFQPSPESGECVDI 1260
G C+ +VD+C DP G CV+ G ++C C GF G D+
Sbjct: 1213 -TQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEG---DV 1268
Query: 1261 DECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFC- 1319
+EC GT C + C C+ G C + C + G C
Sbjct: 1269 NECLSNPCDARGTQNCVQRVNDFHCE--CRAGH---TGRRCESVINGCKGKPCKNGGTCA 1323
Query: 1320 --DNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCEN----VEG--SFLCL 1371
NT F C C GFE + CE CG+ C N + G S CL
Sbjct: 1324 VASNTARGFICKCPAGFEGA----------TCENDARTCGSLRCLNGGTCISGPRSPTCL 1373
Query: 1372 C 1372
C
Sbjct: 1374 C 1374
Score = 167 bits (424), Expect = 7e-41
Identities = 164/616 (26%), Positives = 229/616 (37%), Gaps = 174/616 (28%)
Query: 859 GTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGKGRCINRVGSYSCFCYPGY 917
GTCV+ + + C+C PG+ + +YC D NEC PC G C + GSY C C GY
Sbjct: 996 GTCVDGINSFTCLCPPGF----TGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGY 1051
Query: 918 TLATSGATQECQD-INECEQPGVCSGGQCTNTEGSYHCECDQG----YIMVRKGHCQDIN 972
T CQ+ ++ C+ +GG+C T Y CEC G Y V C+
Sbjct: 1052 T------GPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAA 1105
Query: 973 E---------CRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG 1023
+ C+H G C D G+ C+ GY G C D+ + +P C +G
Sbjct: 1106 QRQGVDVARLCQHGGLCVDA------GNTHHCRCQAGYTGSY--CEDLVDECSPSPCQNG 1157
Query: 1024 K-CTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGY 1082
CT+ G + C C GY + +++DEC S G CL+ ++ CS C G
Sbjct: 1158 ATCTDYLGGYSCKCVAGYHGVNCS---EEIDECLSHPCQNGGTCLDLPNTYKCS-CPRG- 1212
Query: 1083 WVNEDGTACE-DLDECAFPGVCP---------SGVCTNTAGSFSCKDCDGGYRPSPLGDS 1132
G CE ++D+C P V P +G C + G +SC C G+ +G+
Sbjct: 1213 ---TQGVHCEINVDDCN-PPVDPVSRSPKCFNNGTCVDQVGGYSCT-CPPGF----VGER 1263
Query: 1133 CE-DVDEC---------------------------------EDPQSSCLGGECKN----- 1153
CE DV+EC E + C G CKN
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCA 1323
Query: 1154 ----TVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVS 1209
T + C CP GF+ G CE+ G C G C++ S CLC F
Sbjct: 1324 VASNTARGFICKCPAGFE---GATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFT- 1379
Query: 1210 AEGGTSCQDVDECATTDPCVGGHCVNTEGS---------FNCLCETGFQ----------- 1249
G CQ + PC+GG+ +G+ + CLC F
Sbjct: 1380 ---GPECQ----FPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSF 1432
Query: 1250 --------PSPESGECVDIDEC-EDYGDPVCGTWKCENSPGSY--------------RCV 1286
P P E ++ EC ED G+ VC +C N + C
Sbjct: 1433 GGGAGRDIPPPLIEEACELPECQEDAGNKVCSL-QCNNHACGWDGGDCSLNFNDPWKNCT 1491
Query: 1287 LGCQPGFHMAPNGDCIDIDECANDTMCGSHGF-CDNTDGSFRCL-------------CDQ 1332
Q + + +G C D N C GF C +G L CDQ
Sbjct: 1492 QSLQCWKYFS-DGHC---DSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQ 1547
Query: 1333 GFEISPSGWDCVDVNE 1348
G + WD +D E
Sbjct: 1548 GCNSAECEWDGLDCAE 1563
Score = 155 bits (391), Expect = 4e-37
Identities = 201/815 (24%), Positives = 287/815 (35%), Gaps = 196/815 (24%)
Query: 1097 CAFPG--VCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNT 1154
C+ PG G C G+ +C C G + +G C+D + CL CKN
Sbjct: 24 CSQPGETCLNGGKCEAANGTEACV-CGGAF----VGPRCQD-------PNPCLSTPCKNA 71
Query: 1155 ----------VGSYQCLCPQGFQLANGTVCEDV--NECMGEEHCAPHGEC-LNSHGSFFC 1201
V Y C C GF +G +C N C+ C G C L + + C
Sbjct: 72 GTCHVVDRRGVADYACSCALGF---SGPLCLTPLDNACLTNP-CRNGGTCDLLTLTEYKC 127
Query: 1202 LCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDID 1261
C PG+ G SCQ D CA+ GG C+ E S+ C C F P + D++
Sbjct: 128 RCPPGW----SGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH-GPTCRQ--DVN 180
Query: 1262 ECEDYGDPVCGTWKCENSPGSYRCVL-------------------GCQPGFHMAPNGD-- 1300
EC C N GSYRCV CQ G P GD
Sbjct: 181 ECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVT 240
Query: 1301 ----CI----------DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCV-D 1345
C+ +ID+C + C + G C + ++ C C + +G C D
Sbjct: 241 HECACLPGFTGQNCEENIDDCPGNN-CKNGGACVDGVNTYNCRCPPEW----TGQYCTED 295
Query: 1346 VNECELMLAVC-GAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDH 1404
V+EC+LM C C N G + C+C + D E + A
Sbjct: 296 VDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENI--------DDCASAACFHG 347
Query: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
A R+ + + H + N + C + + G CD P A IC
Sbjct: 348 ATCHDRVASFYCECPHGRTGLLCHLN----DACISNPCNEGSNCDTNPVNGKA----ICT 399
Query: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPN-GRCLNTVPGYVCLCNPGFHYDASH 1523
GY G D DEC + G C + G+C+NT+ + C C G+ +
Sbjct: 400 CPSGYT--------GPACSQDVDECSL-GANPCEHAGKCINTLGSFECQCLQGY----TG 446
Query: 1524 KKCE-DHDECQDLACEN-GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDI 1581
+CE D +EC C+N C++ G F C C P C +T P +
Sbjct: 447 PRCEIDVNECVSNPCQNDATCLDQIGEFQCICMP----GYEGVHCEVNTDECASSP--CL 500
Query: 1582 HMDICWKKVTNDVCSEP--LRGHRTTY--TECC---CQDGEAWSQQCALCPPRSSEVYAQ 1634
H C K+ C P GH Y EC C++G +C P Y
Sbjct: 501 HNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG----AKCLDGP----NTYTC 552
Query: 1635 LCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNT 1694
+C E G H + PD HY DG + L P
Sbjct: 553 VC------TEGYTGTHCEVDID-ECDPDPCHYGSC-KDGVATFTCL---------CRPGY 595
Query: 1695 AGHSADRTPILESPLQP-------SELQPHYVASHPEPPAGFE-GLQAEECGILNGCENG 1746
GH + T I E QP + Y+ + G + ++C + C++G
Sbjct: 596 TGHHCE-TNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCA-SSPCDSG 653
Query: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNEC------------DDLNG----------- 1783
C+ +GY C C G+ M ++++EC D +NG
Sbjct: 654 TCLDKIDGYECACEPGY---TGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHD 710
Query: 1784 PAVL----------CVHGYCENTEGSYRCHCSPGY 1808
P L CVHG C ++ Y+C C PG+
Sbjct: 711 PTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGW 745
Score = 134 bits (338), Expect = 6e-31
Identities = 208/852 (24%), Positives = 297/852 (34%), Gaps = 212/852 (24%)
Query: 554 CYLNTVNGQCANPLLELTTQEDC-----CGSVGAFWGVT---LCAPCPPRPA-------- 597
C N +N +NP L T D C + + G T + APC P P
Sbjct: 788 CQTN-INECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQ 846
Query: 598 SPVIENGQLECPQGYKRLNLTHCQ-DINECLTLGLCKDAECVNTRGSY------------ 644
S E+ CP G++ C+ DINEC+ A C NT G Y
Sbjct: 847 SEDYESFSCVCPTGWQGQT---CEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRN 903
Query: 645 --------------------------LCTCRPGL---MLDPSRSRCVSDKAISMLQGLCY 675
C C PG + + C SD + C
Sbjct: 904 CETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGAN--CT 961
Query: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEK---CPLPGTEAFREICPAGHGYTY 732
+ TCT P I C + S C C + G +F +CP G +Y
Sbjct: 962 DCVDSYTCTCPAG---FSGIHCENNTPDCTESSCFNGGTC-VDGINSFTCLCPPGFTGSY 1017
Query: 733 ASSDIRLSMRKAEEEELARPPREQGQRSSGA----------LPGPAERQPLRVVTDTWLE 782
D+ E ++P G G GP + + W +
Sbjct: 1018 CQHDVN--------ECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVH-----WCD 1064
Query: 783 AGTIPDKGDSQAGQVTTSVT-HAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLS 841
+ P K + Q T P+ TG PS V
Sbjct: 1065 SS--PCKNGGKCWQTHTQYRCECPSGWTGLYCD----------------VPSVSCEVAAQ 1106
Query: 842 TPGIDRCAAGATNVCGPG-TCVNLPDGYRCVCSPGYQLHPSQAYCTD-DNECLRDPCKGK 899
G+D +C G CV+ + + C C GY + +YC D +EC PC+
Sbjct: 1107 RQGVD-----VARLCQHGGLCVDAGNTHHCRCQAGY----TGSYCEDLVDECSPSPCQNG 1157
Query: 900 GRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQG 959
C + +G YSC C GY ++I+EC +GG C + +Y C C +G
Sbjct: 1158 ATCTDYLGGYSCKCVAGY-----HGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRG 1212
Query: 960 YIMVRKGHCQ-DINEC--------RHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVD 1010
+ HC+ ++++C R P +G CV+ G Y+C C G+ G+ D
Sbjct: 1213 ---TQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSC-TCPPGFVGERCE-GD 1267
Query: 1011 VNECLTPGVCAHG--KCTNLEGSFRCSCEQGY---EVTSDEKGCQDVDECASRASCPTGL 1065
VNECL+ A G C F C C G+ S GC+ C + +C +
Sbjct: 1268 VNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKG-KPCKNGGTC--AV 1324
Query: 1066 CLNTEGSFACSACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGY 1124
NT F C C G+ +G CE D C G C + S +C C G +
Sbjct: 1325 ASNTARGFICK-CPAGF----EGATCENDARTCGSLRCLNGGTCISGPRSPTCL-CLGPF 1378
Query: 1125 RPSPLGDSCEDVDECEDPQSS-CLGGE-------CKNTVGS--YQCLCPQGFQLANGTVC 1174
EC+ P SS CLGG C+ T S Y+CLCP F NG +C
Sbjct: 1379 TG----------PECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKF---NGLLC 1425
Query: 1175 EDVNECMG------------EEHCAPHGECLNSHGSFFC--LCAPGFVSAEGGTSCQDVD 1220
++ G EE C EC G+ C C +GG + +
Sbjct: 1426 HILDYSFGGGAGRDIPPPLIEEAC-ELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFN 1484
Query: 1221 E----CATTDPC----VGGHCVNTEGSFNCLCETGFQPSPESGECVDIDE--CED----- 1265
+ C + C GHC + S CL + GF G+C + + C+D
Sbjct: 1485 DPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFD-GFDCQRAEGQCNPLYDQYCKDHFSDG 1543
Query: 1266 YGDPVCGTWKCE 1277
+ D C + +CE
Sbjct: 1544 HCDQGCNSAECE 1555
Score = 41.2 bits (95), Expect = 0.009
Identities = 83/337 (24%), Positives = 109/337 (32%), Gaps = 66/337 (19%)
Query: 1500 GRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN-GEC--VNTEGSFHCFCSPP 1556
G+C C+C F +C+D + C C+N G C V+ G CS
Sbjct: 35 GKCEAANGTEACVCGGAF----VGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACS-- 88
Query: 1557 LTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRT----TYTECCCQ 1612
C S +C + N + P R T T TE C+
Sbjct: 89 ---------CALGFSGP-----------LCLTPLDNACLTNPCRNGGTCDLLTLTEYKCR 128
Query: 1613 DGEAWS-QQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGP 1671
WS + C P +S A EA H P + D++ P
Sbjct: 129 CPPGWSGKSCQQADPCASNPCANGGQCLPFEASYIC--HCPPSFHGPTCRQDVNECGQKP 186
Query: 1672 D----GAPFYNYLGPEDTVPEPAFPNTAGHSADR--TPILESPLQ------PSELQPHYV 1719
G +N +G V G + +R P SP Q P+ H
Sbjct: 187 GLCRHGGTCHNEVGSYRCVCRATH---TGPNCERPYVPCSPSPCQNGGTCRPTGDVTHEC 243
Query: 1720 ASHPEPPAGFEGLQAEE----CGILNGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVD 1774
A P GF G EE C N C+NG CV Y C C + D
Sbjct: 244 ACLP----GFTGQNCEENIDDCPG-NNCKNGGACVDGVNTYNCRCPPEW---TGQYCTED 295
Query: 1775 VNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAE 1811
V+EC + P G C NT G Y C C G+ E
Sbjct: 296 VDECQLM--PNACQNGGTCHNTHGGYNCVCVNGWTGE 330
Score = 40.4 bits (93), Expect = 0.016
Identities = 78/367 (21%), Positives = 118/367 (32%), Gaps = 74/367 (20%)
Query: 364 CARGHCANSCE-----------RGDTTTLYSQGGHGHDPKSGFRIYFCQI--------PC 404
C +G+ CE + D T L G G+ C++ PC
Sbjct: 440 CLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPC 499
Query: 405 LNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLP 461
L+ GRC I +C CP TG C + + P G++ L+ P +T+T
Sbjct: 500 LHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAK---CLDGP---NTYTCV 553
Query: 462 LSNQLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGH 521
+ + V + P G ++ + + R P GH
Sbjct: 554 CTEGYTGTHCE-VDIDECDPDPCHY---------GSCKDGVATFTCLCR-----PGYTGH 598
Query: 522 SLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQC-------------ANPLL 568
NI S +P R R L C T C + L
Sbjct: 599 HC--ETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCL 656
Query: 569 ELTTQEDCC---GSVGAFWGVTL--CA--PCPPRPASPVIENG-QLECPQGYKRLNLTHC 620
+ +C G G+ + + CA PC NG CP+GY + T
Sbjct: 657 DKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYH--DPTCL 714
Query: 621 QDINECLTLGLCKDAECVNTRGSYLCTCRP---GLMLDPSRSRCVSDKAISMLQGLCYRS 677
++NEC C C ++ Y C C P G D + + C S+ ++ G C
Sbjct: 715 SEVNEC-NSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVN--GGTCKDM 771
Query: 678 LGPGTCT 684
CT
Sbjct: 772 TSGYVCT 778
Score = 38.5 bits (88), Expect = 0.060
Identities = 28/79 (35%), Positives = 35/79 (44%), Gaps = 7/79 (8%)
Query: 157 TPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPV--CEP-PCQNRGSCS---RPQLCVCR 210
+P R + +N GG C S +C + C P PC N GSC+ C C
Sbjct: 876 SPCRHGASCQNTHGGYRCH-CQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCL 934
Query: 211 SGFRGARCEEVIPDEEFDP 229
GFRG CEE I + DP
Sbjct: 935 PGFRGTFCEEDINECASDP 953
Score = 38.1 bits (87), Expect = 0.079
Identities = 28/69 (40%), Positives = 30/69 (43%), Gaps = 10/69 (14%)
Query: 164 TGRNVCGGQCCPGWTTANSTNHCIKPV--CEP-PCQNRGSCSRP-----QLCVCRSGFRG 215
T N G C T N C +P C P PCQN G+C RP C C GF G
Sbjct: 194 TCHNEVGSYRCVCRATHTGPN-CERPYVPCSPSPCQNGGTC-RPTGDVTHECACLPGFTG 251
Query: 216 ARCEEVIPD 224
CEE I D
Sbjct: 252 QNCEENIDD 260
Score = 37.7 bits (86), Expect = 0.10
Identities = 21/63 (33%), Positives = 29/63 (46%), Gaps = 10/63 (15%)
Query: 173 CCPGWTTAN---STNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGARCEEVIPDEE 226
C PGW+ N + N C PC N G+C + +C CR GF G C+ I +
Sbjct: 741 CDPGWSGTNCDINNNECESN----PCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECA 796
Query: 227 FDP 229
+P
Sbjct: 797 SNP 799
Score = 37.4 bits (85), Expect = 0.13
Identities = 35/147 (23%), Positives = 55/147 (37%), Gaps = 20/147 (13%)
Query: 591 PCPPRPASPVIENGQLECPQGYKR----LNLTHCQDINECLTLGLCKDAECVNTRGSYLC 646
PC + + +C G+ +N C+ N C+ G CKD Y+C
Sbjct: 724 PCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECES-NPCVNGGTCKDMT-----SGYVC 777
Query: 647 TCRPGLM---LDPSRSRCVSDKAISMLQGLCYRSLG--PGTCTLPLAQRITKQICC-CSR 700
TCR G + + C S+ ++ QG C + C LP + + C+
Sbjct: 778 TCREGFSGPNCQTNINECASNPCLN--QGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAP 835
Query: 701 VGKAWGSECEKCPLPGTEAFREICPAG 727
G EC + E+F +CP G
Sbjct: 836 SPCRNGGECRQS--EDYESFSCVCPTG 860
Score = 35.8 bits (81), Expect = 0.39
Identities = 19/62 (30%), Positives = 26/62 (41%), Gaps = 4/62 (6%)
Query: 172 QC-CPGWTTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGARCEEVIPDEEF 227
QC CP T + + + PC+N C CVC G+ G CE I + +
Sbjct: 513 QCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDP 572
Query: 228 DP 229
DP
Sbjct: 573 DP 574
Score = 35.4 bits (80), Expect = 0.51
Identities = 25/77 (32%), Positives = 30/77 (38%), Gaps = 13/77 (16%)
Query: 584 WGVTLCAPCPPRPASPVIENGQL---------ECPQGYKRLNLTHCQDINEC-LTLGLCK 633
W C P ++P GQ CP + T QD+NEC GLC+
Sbjct: 133 WSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFH--GPTCRQDVNECGQKPGLCR 190
Query: 634 DA-ECVNTRGSYLCTCR 649
C N GSY C CR
Sbjct: 191 HGGTCHNEVGSYRCVCR 207
Score = 35.0 bits (79), Expect = 0.67
Identities = 70/303 (23%), Positives = 99/303 (32%), Gaps = 69/303 (22%)
Query: 170 GGQCCPGWTTANSTNHC-------------IKPVCEP-PCQNRGSCSR---PQLCVCRSG 212
GG C A +T+HC + C P PCQN +C+ C C +G
Sbjct: 1119 GGLC----VDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAG 1174
Query: 213 FRGARCEEVIPDEEFDP-QNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAP 271
+ G C E I + P QN PN + S + P P
Sbjct: 1175 YHGVNCSEEIDECLSHPCQNGGTCLDL-----PNTYKCSCPRGTQGVHCEINVDDCNP-P 1228
Query: 272 QSPPAGTLSGLSQTHPSQQHVGLSRTVRLHPTATASSQLS--SNALPPGPGLEQRDGTQQ 329
P +SR+ + T Q+ S PPG E+ +G
Sbjct: 1229 VDP-------------------VSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVN 1269
Query: 330 AVPLEHPSSPWGL-NLTEKIK----KIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQ 384
L +P G N +++ + + T C ++ G C+ G T + S
Sbjct: 1270 EC-LSNPCDARGTQNCVQRVNDFHCECRAGHTGRRC-ESVINGCKGKPCKNGGTCAVASN 1327
Query: 385 GGHGHDPK--SGFRIYFCQ--------IPCLNGGRCIG---RDECWCPANSTGKFCHLPI 431
G K +GF C+ + CLNGG CI C C TG C P
Sbjct: 1328 TARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPA 1387
Query: 432 PQP 434
P
Sbjct: 1388 SSP 1390
Score = 35.0 bits (79), Expect = 0.67
Identities = 30/89 (33%), Positives = 34/89 (38%), Gaps = 19/89 (21%)
Query: 1726 PAGFEGLQAEE----CGILNGCENGRCVRVREGYTCDC---FEGFQLD-AAHMACVDVNE 1777
PAGFEG E CG L G C+ TC C F G + A C+ N
Sbjct: 1337 PAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNP 1396
Query: 1778 CDDLNGPAVLCVHGYCENTEGS--YRCHC 1804
C + G CE T S YRC C
Sbjct: 1397 CYN---------QGTCEPTSESPFYRCLC 1416
Score = 34.3 bits (77), Expect = 1.1
Identities = 22/64 (34%), Positives = 27/64 (42%), Gaps = 4/64 (6%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRPQ---LCVCRSGFRGARCEE 220
G N +C P WT T + P CQN G+C CVC +G+ G C E
Sbjct: 275 GVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSE 334
Query: 221 VIPD 224
I D
Sbjct: 335 NIDD 338
Score = 34.3 bits (77), Expect = 1.1
Identities = 26/98 (26%), Positives = 35/98 (35%), Gaps = 19/98 (19%)
Query: 355 FTPTICKQT---CARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQ--------IP 403
F T C++ CA C N D Y+ +GF C+
Sbjct: 937 FRGTFCEEDINECASDPCRNGANCTDCVDSYTC-----TCPAGFSGIHCENNTPDCTESS 991
Query: 404 CLNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREP 438
C NGG C I C CP TG +C + + D +P
Sbjct: 992 CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQP 1029
Score = 33.9 bits (76), Expect = 1.5
Identities = 19/63 (30%), Positives = 24/63 (38%), Gaps = 4/63 (6%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSR---PQLCVCRSGFRGARCEEV 221
G N C PG+ I PC+N +C+ C C +GF G CE
Sbjct: 925 GINTAFCDCLPGFR-GTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENN 983
Query: 222 IPD 224
PD
Sbjct: 984 TPD 986
Score = 33.9 bits (76), Expect = 1.5
Identities = 22/68 (32%), Positives = 30/68 (44%), Gaps = 8/68 (11%)
Query: 367 GHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQI-PCLNGGRCIGRD---ECWCPANS 422
G C + C G QG G P +++C PC NGG+C C CP+
Sbjct: 1034 GTCQDGC--GSYRCTCPQGYTG--PNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGW 1089
Query: 423 TGKFCHLP 430
TG +C +P
Sbjct: 1090 TGLYCDVP 1097
Score = 33.1 bits (74), Expect = 2.5
Identities = 22/75 (29%), Positives = 31/75 (41%), Gaps = 7/75 (9%)
Query: 156 PTPPRGRLTGRNVCGG---QCCPGWTTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVC 209
P+P + T + GG +C G+ N + I PCQN G+C C C
Sbjct: 1151 PSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEE-IDECLSHPCQNGGTCLDLPNTYKCSC 1209
Query: 210 RSGFRGARCEEVIPD 224
G +G CE + D
Sbjct: 1210 PRGTQGVHCEINVDD 1224
Score = 32.7 bits (73), Expect = 3.3
Identities = 21/66 (31%), Positives = 28/66 (42%), Gaps = 10/66 (15%)
Query: 173 CCPGWTTANSTNHC---IKPVCEPPCQNRGSCS---RPQLCVCRSGFRGARCEEVIPDEE 226
C PG+T +HC I PC++ G+C LC C G G CE + D
Sbjct: 591 CRPGYTG----HHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCA 646
Query: 227 FDPQNS 232
P +S
Sbjct: 647 SSPCDS 652
Score = 32.3 bits (72), Expect = 4.3
Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 6/59 (10%)
Query: 167 NVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRPQ-----LCVCRSGFRGARCE 219
+V G +C +T + C P PC+N G C + + CVC +G++G CE
Sbjct: 809 DVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCE 867
Score = 32.0 bits (71), Expect = 5.6
Identities = 23/78 (29%), Positives = 32/78 (41%), Gaps = 14/78 (17%)
Query: 373 CERGDTTTLYSQGGHGHDPKSGFRIYFCQI--------PCLNGGRCI---GRDECWCPAN 421
C+ G T T Y GG+ +G+ C PC NGG C+ +C CP
Sbjct: 1154 CQNGATCTDYL-GGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRG 1212
Query: 422 STGKFCHLPIPQPDREPP 439
+ G C + + D PP
Sbjct: 1213 TQGVHCEINV--DDCNPP 1228
Score = 31.2 bits (69), Expect = 9.6
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 12/55 (21%)
Query: 172 QCCPGWTTAN---STNHCIKPVCEPPCQNRGSCSRPQL----CVCRSGFRGARCE 219
QC G+T N C+ PCQN +C Q+ C+C G+ G CE
Sbjct: 439 QCLQGYTGPRCEIDVNECVSN----PCQNDATCL-DQIGEFQCICMPGYEGVHCE 488
Score = 31.2 bits (69), Expect = 9.6
Identities = 16/45 (35%), Positives = 19/45 (42%), Gaps = 3/45 (6%)
Query: 403 PCLNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREPPGRGSR 444
PCL+GG C G C CP TG C + D P G +
Sbjct: 1029 PCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGK 1073
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 259 bits (661), Expect = 2e-68
Identities = 250/888 (28%), Positives = 338/888 (38%), Gaps = 242/888 (27%)
Query: 859 GTCVNLP-DGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGY 917
GTC L D Y C C G+ + C + CL PC C +SC C G+
Sbjct: 119 GTCHMLSRDTYECTCQVGF----TGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGF 174
Query: 918 TLATSGATQECQ-DINECEQPGVCS-GGQCTNTEGSYHCECDQG---------YIMVRKG 966
T Q+C+ D+NEC+ PG C GG C N GSY C+C QG Y+
Sbjct: 175 T------GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPS 228
Query: 967 HCQDINECRHPG----------------------TCPD------GRCVNSPGSYTCLACE 998
C + CR G CP+ G CV+ +Y C C
Sbjct: 229 PCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNC-RCP 287
Query: 999 EGYRGQSGSCVDVNEC-LTPGVCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
+ GQ DV+EC L P C + G C N G + C C G+ S + +++D+CA
Sbjct: 288 PQWTGQF-CTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGW---SGDDCSENIDDCA 343
Query: 1057 SRASCPTGLCLNTEGSFACSACE-----------------------------NGYWV--- 1084
+ P C++ SF+C E NG ++
Sbjct: 344 FASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTC 403
Query: 1085 --NEDGTAC-EDLDECAFPGVCP---SGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVD 1137
G C ED+DECA P +G C NT G+F C +C GY G CE D++
Sbjct: 404 PQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHC-ECLKGY----AGPRCEMDIN 458
Query: 1138 EC-EDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNS 1195
EC DP + C + +G + CLC GF+ G CE ++NEC C +G+C++
Sbjct: 459 ECHSDPCQN--DATCLDKIGGFTCLCMPGFK---GVHCELEINECQSNP-CVNNGQCVDK 512
Query: 1196 HGSFFCLCAPGFVSAEGGTSCQ-DVDECATTDPCV-GGHCVNTEGSFNCLCETGF----- 1248
F CLC PGF G CQ D+D+C++T PC+ G C++ + C C TGF
Sbjct: 513 VNRFQCLCPPGFT----GPVCQIDIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGVLC 567
Query: 1249 -------QPSP-ESGECVD---------------------IDECEDYGDPVCGTWKCENS 1279
P P G+C D IDEC Y P +C +
Sbjct: 568 EENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDEC--YSSPCLNDGRCIDL 625
Query: 1280 PGSYRCVLGCQPG---------FHMAPNGDC--------------------------IDI 1304
Y+C CQPG F + C IDI
Sbjct: 626 VNGYQC--NCQPGTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDI 683
Query: 1305 DECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCV-DVNECELMLAVCGAALCEN 1363
DECA++ C C N FRC+C +G P C VNEC + C C
Sbjct: 684 DECASNP-CRKGATCINGVNGFRCICPEG----PHHPSCYSQVNEC--LSNPCIHGNCTG 736
Query: 1364 VEGSFLCLCASDLE----EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG 1419
+ CLC + E D E P GG T D+ R C G KG
Sbjct: 737 GLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGG-------TCDNLVNGYRCTCKKGFKG 789
Query: 1420 HAPCSSVLGRNTTQAECCCTQGASWGD----------------------ACDLCPSEDSA 1457
+ + + + + C QG + D C P E++A
Sbjct: 790 Y---NCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAA 846
Query: 1458 EFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGF 1517
E P+ + Y + GQ D DEC+ +G C NT Y+C C PGF
Sbjct: 847 VCKE-SPNFESYTCLCAPGWQGQRCTIDIDECI--SKPCMNHGLCHNTQGSYMCECPPGF 903
Query: 1518 HYDASHKKC-EDHDECQDLACEN-GECVNTEGSFHCFCSPPLTLDLSQ 1563
S C ED D+C C+N G C++ +F C C P T D Q
Sbjct: 904 ----SGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Score = 251 bits (640), Expect = 6e-66
Identities = 276/1037 (26%), Positives = 390/1037 (37%), Gaps = 209/1037 (20%)
Query: 842 TPGIDRCAAGATNVCG-PGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKG 900
T +D CA +N C G CVN + C C GY + D NEC DPC+
Sbjct: 413 TEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM---DINECHSDPCQNDA 469
Query: 901 RCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGY 960
C++++G ++C C PG+ G E +INEC+ + GQC + + C C G+
Sbjct: 470 TCLDKIGGFTCLCMPGF----KGVHCEL-EINECQSNPCVNNGQCVDKVNRFQCLCPPGF 524
Query: 961 IMVRKGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGV 1019
CQ DI++C +C++ P Y C C G+ G C + + P
Sbjct: 525 ---TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYEC-QCATGFTGV--LCEENIDNCDPDP 578
Query: 1020 CAHGKCTNLEGSFRCSCEQGY--EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSA 1077
C HG+C + S+ C C GY + SD+ +DEC S G C++ + C+
Sbjct: 579 CHHGQCQDGIDSYTCICNPGYMGAICSDQ-----IDECYSSPCLNDGRCIDLVNGYQCN- 632
Query: 1078 CENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-D 1135
C+ G G CE + D+CA C G+C + +SC C G+ G C D
Sbjct: 633 CQPG----TSGVNCEINFDDCA-SNPCIHGICMDGINRYSCV-CSPGF----TGQRCNID 682
Query: 1136 VDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLN 1194
+DEC + C G C N V ++C+CP+G + + VNEC+ HG C
Sbjct: 683 IDEC--ASNPCRKGATCINGVNGFRCICPEGPH--HPSCYSQVNECLSNP--CIHGNCTG 736
Query: 1195 SHGSFFCLCAPGFVSAEGGTSCQ-DVDECATTDPCV-GGHCVNTEGSFNCLCETGFQ--- 1249
+ CLC G+V G +C+ D +EC ++PC GG C N + C C+ GF+
Sbjct: 737 GLSGYKCLCDAGWV----GINCEVDKNEC-LSNPCQNGGTCDNLVNGYRCTCKKGFKGYN 791
Query: 1250 -----------PSPESGECVDI--------------DECEDYGDPVCGTWKCEN------ 1278
P G C D C+ P C CEN
Sbjct: 792 CQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAP-CSPNPCENAAVCKE 850
Query: 1279 SPG--SYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEI 1336
SP SY C+ C PG+ IDIDEC + C +HG C NT GS+ C C GF
Sbjct: 851 SPNFESYTCL--CAPGWQ--GQRCTIDIDECISKP-CMNHGLCHNTQGSYMCECPPGF-- 903
Query: 1337 SPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLC----ASDLEEYDAQEGHCRPRGA 1391
SG DC D+++C G + + V +F CLC D + D E P
Sbjct: 904 --SGMDCEEDIDDCLANPCQNGGSCMDGV-NTFSCLCLPGFTGDKCQTDMNECLSEPCKN 960
Query: 1392 GGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLC 1451
GG D+ + T C +G G C + + T E C G + D +
Sbjct: 961 GG------TCSDYVNSYT-CKCQAGFDG-VHCENNINECT---ESSCFNGGTCVDGIN-- 1007
Query: 1452 PSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVC 1511
FS +CP G G++ + + C+ G C++ + Y C
Sbjct: 1008 ------SFSCLCPVG-----FTGSFCLHEINECSSHPCL-------NEGTCVDGLGTYRC 1049
Query: 1512 LCNPGFHYDASHKKCED-HDECQDLACEN-GECVNTEGSFHCFCSPPLT---LDLSQQRC 1566
C G+ + K C+ + C C+N G CV + C C D+ C
Sbjct: 1050 SCPLGY----TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSC 1105
Query: 1567 MNSTSSTEDLPDHDI-HMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCP 1625
+ S L +H H +C C PL YT C E +CA P
Sbjct: 1106 DIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPL-----GYTGSYC---EEQLDECASNP 1157
Query: 1626 PRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDT 1685
+ + R E PGY+ + Y + P N
Sbjct: 1158 CQHGATCSDFIGGYRCECV--------PGYQ----GVNCEYEVDECQNQPCQN------- 1198
Query: 1686 VPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEE----CGILN 1741
G D L H+ S P G GL EE C
Sbjct: 1199 ---------GGTCID-------------LVNHFKCS---CPPGTRGLLCEENIDDCARGP 1233
Query: 1742 GCEN-GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
C N G+C+ GY+C C GF A D+NEC L+ P C Y
Sbjct: 1234 HCLNGGQCMDRIGGYSCRCLPGF---AGERCEGDINEC--LSNPCSSEGSLDCIQLTNDY 1288
Query: 1801 RCHCSPGYVAEAGPPHC 1817
C C + HC
Sbjct: 1289 LCVCRSAFTGR----HC 1301
Score = 247 bits (630), Expect = 9e-65
Identities = 272/1058 (25%), Positives = 425/1058 (40%), Gaps = 201/1058 (18%)
Query: 847 RCAAGATNVCGPGTCVNLPDGYR-CVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINR 905
+C G G CV +G C C G+ YC + C ++ C+ G C+ +
Sbjct: 27 QCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFL----GEYCQHRDPCEKNRCQNGGTCVAQ 82
Query: 906 --VGSYSCFCYPGYT-----LATS-----------GAT-------------------QEC 928
+G +C C G+T +TS G T +EC
Sbjct: 83 AMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC 142
Query: 929 QDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQ-DINECRHPGTCP-DGRCV 986
Q + C +G CT + C+C G+ + C+ D+NEC PG C G C+
Sbjct: 143 QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQK---CETDVNECDIPGHCQHGGTCL 199
Query: 987 NSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEG--SFRCSCEQGYEVTS 1044
N PGSY C C +G+ GQ C + P C +G G +F C+C G+E ++
Sbjct: 200 NLPGSYQC-QCPQGFTGQ--YCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGST 256
Query: 1045 DEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF-PGVC 1103
E+ ++D+C + G+C++ ++ C W + T ED+DEC P C
Sbjct: 257 CER---NIDDCPNHRCQNGGVCVDGVNTYNCRCPPQ--WTGQFCT--EDVDECLLQPNAC 309
Query: 1104 PS-GVCTNTAGSFSCKDCDGGYRPSPLGDSC-EDVDECEDPQSSCL-GGECKNTVGSYQC 1160
+ G C N G + C C G+ GD C E++D+C +SC G C + V S+ C
Sbjct: 310 QNGGTCANRNGGYGCV-CVNGWS----GDDCSENIDDC--AFASCTPGSTCIDRVASFSC 362
Query: 1161 LCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNS--HGSFFCLCAPGFVSAEGGTSCQD 1218
+CP+G G +C + C+ C C + +G + C C G+ +G +D
Sbjct: 363 MCPEG---KAGLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGY---KGADCTED 415
Query: 1219 VDEC--ATTDPCV-GGHCVNTEGSFNCLCETGFQ-PSPESGECVDIDECEDYGDPVCGTW 1274
VDEC A ++PC G CVNT+G+F+C C G+ P E +DI+EC + DP
Sbjct: 416 VDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE----MDINEC--HSDPCQNDA 469
Query: 1275 KCENSPGSYRCVLGCQPGFHMAPNGDC-IDIDECANDTMCGSHGFCDNTDGSFRCLCDQG 1333
C + G + C+ C PGF C ++I+EC ++ C ++G C + F+CLC G
Sbjct: 470 TCLDKIGGFTCL--CMPGF---KGVHCELEINECQSNP-CVNNGQCVDKVNRFQCLCPPG 523
Query: 1334 FEISPSGWDC-VDVNECELMLAVCGAAL--------CENVEGSFLCLCASDLEEYD---A 1381
F +G C +D+++C + GA C+ G LC +++ D
Sbjct: 524 F----TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPC 579
Query: 1382 QEGHCRPRGAGGQSMSEAPTGDHAPAPTRMD-CYSGQKGHAPCSSVLGR---NTTQAECC 1437
G C+ G + P A ++D CYS +PC + GR +C
Sbjct: 580 HHGQCQD-GIDSYTCICNPGYMGAICSDQIDECYS-----SPCLND-GRCIDLVNGYQCN 632
Query: 1438 CTQGASWGDACDL----CPSEDSAEFSEICPSG-KGYIPVEGAWTFGQTMYTDADECVIF 1492
C G S G C++ C S IC G Y V GQ D DEC
Sbjct: 633 CQPGTS-GVNCEINFDDCASNPC--IHGICMDGINRYSCVCSPGFTGQRCNIDIDEC--- 686
Query: 1493 GPGLCPNG-RCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHC 1551
C G C+N V G+ C+C G H+ + + + +EC C +G C + C
Sbjct: 687 ASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQV---NECLSNPCIHGNCTGGLSGYKC 743
Query: 1552 FCSP---PLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGH--RTTY 1606
C + ++ + C+++ D+ ++ C C + +G+ +
Sbjct: 744 LCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRC-------TCKKGFKGYNCQVNI 796
Query: 1607 TEC----------CCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGYE 1656
EC C D ++ C L P L + E A P +E
Sbjct: 797 DECASNPCLNQGTCFDDISGYTCHCVL-PYTGKNCQTVLAPCSPNPCENAAVCKESPNFE 855
Query: 1657 YGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQP 1716
+ + P + ++ + +P + H+ Q
Sbjct: 856 -------SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNT---------------QG 893
Query: 1717 HYVASHPEPPAGFEGLQAEE----CGILNGCEN-GRCVRVREGYTCDCFEGFQLDAAHMA 1771
Y+ E P GF G+ EE C + N C+N G C+ ++C C GF D
Sbjct: 894 SYMC---ECPPGFSGMDCEEDIDDC-LANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ-- 947
Query: 1772 CVDVNECDDLNGPAVLCVH-GYCENTEGSYRCHCSPGY 1808
D+NEC L+ P C + G C + SY C C G+
Sbjct: 948 -TDMNEC--LSEP---CKNGGTCSDYVNSYTCKCQAGF 979
Score = 229 bits (584), Expect = 2e-59
Identities = 207/739 (28%), Positives = 315/739 (42%), Gaps = 128/739 (17%)
Query: 853 TNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCF 912
+N C G C GY+C+C G+ + D NECL +PC+ G C N V Y C
Sbjct: 726 SNPCIHGNCTGGLSGYKCLCDAGWVGINCEV---DKNECLSNPCQNGGTCDNLVNGYRCT 782
Query: 913 CYPGYTLATSGATQECQ-DINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDI 971
C G+ CQ +I+EC + G C + Y C C Y +CQ +
Sbjct: 783 CKKGFK------GYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYT---GKNCQTV 833
Query: 972 NECRHPGTCPDGR-CVNSPG--SYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNL 1028
P C + C SP SYTCL C G++GQ + +D++EC++ HG C N
Sbjct: 834 LAPCSPNPCENAAVCKESPNFESYTCL-CAPGWQGQRCT-IDIDECISKPCMNHGLCHNT 891
Query: 1029 EGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDG 1088
+GS+ C C G+ E +D+D+C + G C++ +F+C C G+ G
Sbjct: 892 QGSYMCECPPGFSGMDCE---EDIDDCLANPCQNGGSCMDGVNTFSC-LCLPGF----TG 943
Query: 1089 TACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCED-VDECEDPQSSC 1146
C+ D++EC G C++ S++CK C G+ G CE+ ++EC + SSC
Sbjct: 944 DKCQTDMNECLSEPCKNGGTCSDYVNSYTCK-CQAGFD----GVHCENNINECTE--SSC 996
Query: 1147 L-GGECKNTVGSYQCLCPQGFQLANGTVC-EDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204
GG C + + S+ CLCP GF G+ C ++NEC C G C++ G++ C C
Sbjct: 997 FNGGTCVDGINSFSCLCPVGF---TGSFCLHEINECSSHP-CLNEGTCVDGLGTYRCSCP 1052
Query: 1205 PGFVSAEGGTSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPESGECVDIDEC 1263
G+ G +CQ + + PC G CV + CLC +G+ + V D
Sbjct: 1053 LGYT----GKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIA 1108
Query: 1264 EDYG----DPVCG-TWKCENSPGSYRCVLGCQPGFHMAPNGDCID-IDECANDTMCGSHG 1317
+ +C + C N+ ++ C C G+ C + +DECA++ C
Sbjct: 1109 ASRRGVLVEHLCQHSGVCINAGNTHYCQ--CPLGY---TGSYCEEQLDECASNP-CQHGA 1162
Query: 1318 FCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCASDL 1376
C + G +RC C G++ G +C +V+EC+ G C ++ F C C
Sbjct: 1163 TCSDFIGGYRCECVPGYQ----GVNCEYEVDECQNQPCQNGGT-CIDLVNHFKCSC---- 1213
Query: 1377 EEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC 1436
P G G + E D A P C +G + C +G + C
Sbjct: 1214 -----------PPGTRGL-LCEENIDDCARGP---HCLNGGQ----CMDRIGGYS----C 1250
Query: 1437 CCTQGASWGDACD---------LCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDAD 1487
C G + G+ C+ C SE S + ++ Y+ V + G+ T D
Sbjct: 1251 RCLPGFA-GERCEGDINECLSNPCSSEGSLDCIQLT---NDYLCVCRSAFTGRHCETFVD 1306
Query: 1488 ECVIFGPGLCPNGRCLN--------TVP-GYVCLCNPGFHYDASHKKCEDHDECQDLACE 1538
+CP CLN +P G++C C PGF S +C+ C + C
Sbjct: 1307 --------VCPQMPCLNGGTCAVASNMPDGFICRCPPGF----SGARCQS--SCGQVKCR 1352
Query: 1539 NGE-CVNTEGSFHCFCSPP 1556
GE CV+T CFC P
Sbjct: 1353 KGEQCVHTASGPRCFCPSP 1371
Score = 206 bits (524), Expect = 2e-52
Identities = 266/1040 (25%), Positives = 389/1040 (37%), Gaps = 175/1040 (16%)
Query: 591 PCPPRPASPVIENGQLECPQGYKRLNLTHCQD-INECLTLGLCKDAECVNTRGSYLCTCR 649
PC I++ C GY C D I+EC + D C++ Y C C+
Sbjct: 578 PCHHGQCQDGIDSYTCICNPGYMG---AICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQ 634
Query: 650 P---GLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLP---LAQRITKQICCCSRVGK 703
P G+ + + C S+ I G+C + +C QR I C+
Sbjct: 635 PGTSGVNCEINFDDCASNPCI---HGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPC 691
Query: 704 AWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGA 763
G+ C + G FR ICP G + S + E P G +G
Sbjct: 692 RKGATC----INGVNGFRCICPEGPHHPSCYSQV---------NECLSNPCIHG-NCTGG 737
Query: 764 LPGPAERQPLRVVTDT-WLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGI 822
L G + + D W+ DK + + T V G T +G
Sbjct: 738 LSG------YKCLCDAGWVGINCEVDKNECLSNPCQNGGT-CDNLVNGYRCTCKKGFKGY 790
Query: 823 AEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVC-GPGTCVNLPDGYRCVCSPGYQLHPS 881
ID C A+N C GTC + GY C C Y
Sbjct: 791 N-----------------CQVNIDEC---ASNPCLNQGTCFDDISGYTCHCVLPYTGKNC 830
Query: 882 QAYCTDDNECLRDPCKGKGRCIN--RVGSYSCFCYPGYTLATSGATQECQ-DINECEQPG 938
Q C +PC+ C SY+C C PG+ Q C DI+EC
Sbjct: 831 QTVLA---PCSPNPCENAAVCKESPNFESYTCLCAPGW------QGQRCTIDIDECISKP 881
Query: 939 VCSGGQCTNTEGSYHCECDQGYIMVRKGHC-QDINECRHPGTCPDGRCVNSPGSYTCLAC 997
+ G C NT+GSY CEC G+ + C +DI++C G C++ +++CL C
Sbjct: 882 CMNHGLCHNTQGSYMCECPPGFSGM---DCEEDIDDCLANPCQNGGSCMDGVNTFSCL-C 937
Query: 998 EEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECAS 1057
G+ G D+NECL+ G C++ S+ C C+ G++ E +++EC
Sbjct: 938 LPGFTGDKCQ-TDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCE---NNINECTE 993
Query: 1058 RASCPTGLCLNTEGSFACSACENGYWVNEDGTAC-EDLDECAFPGVCPSGVCTNTAGSFS 1116
+ G C++ SF+C C G+ G+ C +++EC+ G C + G++
Sbjct: 994 SSCFNGGTCVDGINSFSC-LCPVGF----TGSFCLHEINECSSHPCLNEGTCVDGLGTYR 1048
Query: 1117 CKDCDGGYRPSPLGDSCED-VDECEDPQSSCLG-GECKNTVGSYQCLCPQGFQLANGTVC 1174
C C GY G +C+ V+ C +S C G C QCLCP G+ G C
Sbjct: 1049 C-SCPLGY----TGKNCQTLVNLCS--RSPCKNKGTCVQKKAESQCLCPSGWA---GAYC 1098
Query: 1175 EDVN-EC---------MGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD-VDECA 1223
+ N C + E C G C+N+ + +C C G+ G+ C++ +DECA
Sbjct: 1099 DVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYT----GSYCEEQLDECA 1154
Query: 1224 TTDPCV-GGHCVNTEGSFNCLCETGFQPSPESGEC-VDIDECEDYGDPVCGTWKCENSPG 1281
++PC G C + G + C C G+Q C ++DEC++ P C +
Sbjct: 1155 -SNPCQHGATCSDFIGGYRCECVPGYQ----GVNCEYEVDECQN--QPCQNGGTCIDLVN 1207
Query: 1282 SYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGW 1341
++C C PG + +ID+CA C + G C + G + C C GF +G
Sbjct: 1208 HFKC--SCPPGTRGLLCEE--NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF----AGE 1259
Query: 1342 DCV-DVNECELMLAVC---GAALCENVEGSFLCLCASDLEEYDAQEGHCRP--------- 1388
C D+NEC + C G+ C + +LC+C S HC
Sbjct: 1260 RCEGDINEC--LSNPCSSEGSLDCIQLTNDYLCVCRSAF-----TGRHCETFVDVCPQMP 1312
Query: 1389 --RGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGD 1446
G S P G P +SG + + C V R Q C AS G
Sbjct: 1313 CLNGGTCAVASNMPDGFICRCPPG---FSGARCQSSCGQVKCRKGEQ----CVHTAS-GP 1364
Query: 1447 ACDLCPSEDSAE---FSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCL 1503
C CPS E S C G P Q Y F C
Sbjct: 1365 RC-FCPSPRDCESGCASSPCQHGGSCHPQR------QPPYYSCQCAPPFSGSRCELYTAP 1417
Query: 1504 NTVPGYVCLCNPGFHYDASHKKCEDHDE-CQDLAC--ENGECVNTEGSFHCFCSPPLTL- 1559
+ P CL Y A + DE C AC + G+C T + CS PL
Sbjct: 1418 PSTPPATCLS----QYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCW 1473
Query: 1560 DLSQQRCMNSTSSTEDLPDH 1579
D +C ++ E L D+
Sbjct: 1474 DYINNQCDELCNTVECLFDN 1493
Score = 196 bits (498), Expect = 2e-49
Identities = 202/728 (27%), Positives = 285/728 (39%), Gaps = 142/728 (19%)
Query: 845 IDRCAAGATNVC-GPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCI 903
ID C A N C G+C++ + + C+C PG+ Q TD NECL +PCK G C
Sbjct: 912 IDDCLA---NPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ---TDMNECLSEPCKNGGTCS 965
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
+ V SY+C C G+ G E +INEC + +GG C + S+ C C G+
Sbjct: 966 DYVNSYTCKCQAGF----DGVHCE-NNINECTESSCFNGGTCVDGINSFSCLCPVGF--- 1017
Query: 964 RKGHC-QDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAH 1022
C +INEC +G CV+ G+Y C +C GY G++ + VN C
Sbjct: 1018 TGSFCLHEINECSSHPCLNEGTCVDGLGTYRC-SCPLGYTGKNCQTL-VNLCSRSPCKNK 1075
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASC-------PTGLCLNTEGSFAC 1075
G C + +C C G+ + D ASR +G+C+N + C
Sbjct: 1076 GTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYC 1135
Query: 1076 SACENGYWVNEDGTACED-LDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134
C GY G+ CE+ LDECA C++ G + C +C GY+ G +CE
Sbjct: 1136 Q-CPLGY----TGSYCEEQLDECASNPCQHGATCSDFIGGYRC-ECVPGYQ----GVNCE 1185
Query: 1135 -DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCED-VNECMGEEHCAPHGEC 1192
+VDEC++ Q GG C + V ++C CP G G +CE+ +++C HC G+C
Sbjct: 1186 YEVDECQN-QPCQNGGTCIDLVNHFKCSCPPG---TRGLLCEENIDDCARGPHCLNGGQC 1241
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQ-DVDECATTDPCVGG---HCVNTEGSFNCLCETGF 1248
++ G + C C PGF G C+ D++EC ++PC C+ + C+C + F
Sbjct: 1242 MDRIGGYSCRCLPGF----AGERCEGDINEC-LSNPCSSEGSLDCIQLTNDYLCVCRSAF 1296
Query: 1249 QPSPESGECVDIDECEDYGDPVCGTWKC---------ENSPGSYRCVLGCQPGFHMAPNG 1299
CE + D VC C N P + C C PGF A
Sbjct: 1297 TGR----------HCETFVD-VCPQMPCLNGGTCAVASNMPDGFIC--RCPPGFSGA--- 1340
Query: 1300 DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAA 1359
C C +T RC C PS DC + C ++
Sbjct: 1341 ---RCQSSCGQVKCRKGEQCVHTASGPRCFC-------PSPRDCE---------SGCASS 1381
Query: 1360 LCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQ-SMSEAPTGDHAPAPTRMDCYSGQK 1418
C++ GS C Y Q C P +G + + AP P T + Y K
Sbjct: 1382 PCQH-GGS--CHPQRQPPYYSCQ---CAPPFSGSRCELYTAPPS--TPPATCLSQYCADK 1433
Query: 1419 GHAPCSSVLGRNTTQAECCCTQGASW-GDACDLCPSEDSAEFSEICPSGKGYIPVEGAWT 1477
R+ E C + W G C L A S P W
Sbjct: 1434 ---------ARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLP----------CWD 1474
Query: 1478 FGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCN-PGFHYDASHKKCEDH--DECQD 1534
+ + DE LC CL + C N YD K C DH D D
Sbjct: 1475 Y---INNQCDE-------LCNTVECL--FDNFECQGNSKTCKYD---KYCADHFKDNHCD 1519
Query: 1535 LACENGEC 1542
C + EC
Sbjct: 1520 QGCNSEEC 1527
Score = 170 bits (430), Expect = 1e-41
Identities = 190/741 (25%), Positives = 274/741 (36%), Gaps = 123/741 (16%)
Query: 552 GRCYLNTVNG-QCANPLLELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQ 610
G +N VNG +C P E C V L PC + + + C
Sbjct: 694 GATCINGVNGFRCICP--EGPHHPSCYSQVNE----CLSNPCIHGNCTGGLSGYKCLCDA 747
Query: 611 GYKRLNLTHCQ-DINECLTLGLCKDAECVNTRGSYLCTCRPGLM---LDPSRSRCVSDKA 666
G+ +N C+ D NECL+ C N Y CTC+ G + C S+
Sbjct: 748 GWVGIN---CEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPC 804
Query: 667 ISMLQGLCYRSLGPGT--CTLPLAQRITKQICC-CSRVGKAWGSECEKCPLPGTEAFREI 723
++ QG C+ + T C LP + + + CS + C++ P E++ +
Sbjct: 805 LN--QGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKES--PNFESYTCL 860
Query: 724 CPAGHGYTYASSDIRLSMRKAEEEELARP-------PREQGQRSSGALPGPAERQPLRVV 776
C G + DI +E +++P QG PG + +
Sbjct: 861 CAPGWQGQRCTIDI--------DECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDI 912
Query: 777 TDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDV 836
D A + G G T S P + TG+ TD+
Sbjct: 913 DDCL--ANPCQNGGSCMDGVNTFSCLCLPGF-TGDKC-------------------QTDM 950
Query: 837 LVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDP 895
LS P C G GTC + + Y C C G+ +C ++ NEC
Sbjct: 951 NECLSEP----CKNG-------GTCSDYVNSYTCKCQAGF----DGVHCENNINECTESS 995
Query: 896 CKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCE 955
C G C++ + S+SC C G+T + +INEC + G C + G+Y C
Sbjct: 996 CFNGGTCVDGINSFSCLCPVGFT-----GSFCLHEINECSSHPCLNEGTCVDGLGTYRCS 1050
Query: 956 CDQGYIMVRKGHCQD-INECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVN-- 1012
C GY +CQ +N C G CV CL C G+ G +V+
Sbjct: 1051 CPLGY---TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCL-CPSGWAGAYCDVPNVSCD 1106
Query: 1013 ------ECLTPGVCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGL 1065
L +C H G C N + C C GY + E + +DECAS
Sbjct: 1107 IAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE---EQLDECASNPCQHGAT 1163
Query: 1066 CLNTEGSFACSACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGY 1124
C + G + C C GY G CE ++DEC G C + F C C G
Sbjct: 1164 CSDFIGGYRCE-CVPGY----QGVNCEYEVDECQNQPCQNGGTCIDLVNHFKC-SCPPGT 1217
Query: 1125 RPSPLGDSCED-VDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMG 1182
R G CE+ +D+C GG+C + +G Y C C GF G CE D+NEC+
Sbjct: 1218 R----GLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFA---GERCEGDINECLS 1270
Query: 1183 EEHCAPHG--ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCV-GGHCV---NT 1236
C+ G +C+ + C+C F G C+ + PC+ GG C N
Sbjct: 1271 NP-CSSEGSLDCIQLTNDYLCVCRSAFT----GRHCETFVDVCPQMPCLNGGTCAVASNM 1325
Query: 1237 EGSFNCLCETGFQPSPESGEC 1257
F C C GF + C
Sbjct: 1326 PDGFICRCPPGFSGARCQSSC 1346
Score = 48.1 bits (113), Expect = 8e-05
Identities = 72/308 (23%), Positives = 101/308 (32%), Gaps = 67/308 (21%)
Query: 165 GRNVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRPQL---CVCRSGFRGARCEE 220
G N +C P WT T + + +P CQN G+C+ CVC +G+ G C E
Sbjct: 278 GVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSE 337
Query: 221 VIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGT-- 278
I D F S +R + G+ L A S P + T
Sbjct: 338 NIDDCAFA---SCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNP 394
Query: 279 LSGLSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSS 338
L+G Q + G T + A A+S P EH
Sbjct: 395 LNGQYICTCPQGYKGADCTEDVDECAMANSN----------------------PCEHAG- 431
Query: 339 PWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCE-----------RGDTTTLYSQGGH 387
K V T C +G+ CE + D T L GG
Sbjct: 432 -------------KCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGF 478
Query: 388 GHDPKSGFRIYFCQI--------PCLNGGRCI---GRDECWCPANSTGKFCHLPIPQPDR 436
GF+ C++ PC+N G+C+ R +C CP TG C + I
Sbjct: 479 TCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS 538
Query: 437 EPPGRGSR 444
P G++
Sbjct: 539 TPCLNGAK 546
Score = 46.6 bits (109), Expect = 2e-04
Identities = 30/88 (34%), Positives = 41/88 (46%), Gaps = 11/88 (12%)
Query: 1728 GFEGLQAE--ECGILNGCENGR-CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGP 1784
GF G + + + + + C NG C V ++C C GF DVNECD + G
Sbjct: 136 GFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGF---TGQKCETDVNECD-IPGH 191
Query: 1785 AVLCVHG-YCENTEGSYRCHCSPGYVAE 1811
C HG C N GSY+C C G+ +
Sbjct: 192 ---CQHGGTCLNLPGSYQCQCPQGFTGQ 216
Score = 41.6 bits (96), Expect = 0.007
Identities = 39/136 (28%), Positives = 59/136 (43%), Gaps = 19/136 (13%)
Query: 603 NGQL--ECPQGYKRLNLTHCQDINECLTLGL--CKDA-ECVNTRGSYLCTCRPGL---ML 654
NGQ CPQGYK + T +D++EC C+ A +CVNT G++ C C G
Sbjct: 396 NGQYICTCPQGYKGADCT--EDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRC 453
Query: 655 DPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSEC---EK 711
+ + C SD + C +G TC L K + C + + + C +
Sbjct: 454 EMDINECHSDPCQN--DATCLDKIGGFTC---LCMPGFKGVHCELEINECQSNPCVNNGQ 508
Query: 712 CPLPGTEAFREICPAG 727
C + F+ +CP G
Sbjct: 509 C-VDKVNRFQCLCPPG 523
Score = 41.2 bits (95), Expect = 0.009
Identities = 23/58 (39%), Positives = 25/58 (43%), Gaps = 10/58 (17%)
Query: 173 CCPGWTTANST---NHCIKPVCEPPCQNRGSCSRPQ---LCVCRSGFRGARCEEVIPD 224
C PGW T + CI PC N G C Q +C C GF G CEE I D
Sbjct: 861 CAPGWQGQRCTIDIDECISK----PCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDD 914
Score = 39.3 bits (90), Expect = 0.035
Identities = 31/95 (32%), Positives = 40/95 (42%), Gaps = 14/95 (14%)
Query: 1726 PAGFEGL--QAEECGILNGCENGRCVRVRE---GYTCDCFEGFQLDAAHMACVDVNECDD 1780
P G GL ++ I N C G Y C C +G++ DV+EC
Sbjct: 365 PEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK---GADCTEDVDECAM 421
Query: 1781 LNGPAVLCVH-GYCENTEGSYRCHCSPGYVAEAGP 1814
N C H G C NT+G++ C C GY AGP
Sbjct: 422 ANSNP--CEHAGKCVNTDGAFHCECLKGY---AGP 451
Score = 38.1 bits (87), Expect = 0.079
Identities = 22/66 (33%), Positives = 29/66 (43%), Gaps = 10/66 (15%)
Query: 163 LTGRNVCGGQCCPGWT---TANSTNHCIKPVCEPPCQNRGSCS---RPQLCVCRSGFRGA 216
+ G N C PG+T N C+ PC+N G+CS C C++GF G
Sbjct: 927 MDGVNTFSCLCLPGFTGDKCQTDMNECLSE----PCKNGGTCSDYVNSYTCKCQAGFDGV 982
Query: 217 RCEEVI 222
CE I
Sbjct: 983 HCENNI 988
Score = 36.2 bits (82), Expect = 0.30
Identities = 25/66 (37%), Positives = 28/66 (42%), Gaps = 5/66 (7%)
Query: 367 GHCANSCERGDTTTLYSQGGHGHDPK-SGFRIYFCQIPCLNGGRC--IGRD--ECWCPAN 421
G C G T + G G D + S F PCLNGG C + RD EC C
Sbjct: 77 GTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVG 136
Query: 422 STGKFC 427
TGK C
Sbjct: 137 FTGKEC 142
Score = 36.2 bits (82), Expect = 0.30
Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 10/63 (15%)
Query: 173 CCPGWTTAN---STNHCIKPVCEPPCQNRGSCSR---PQLCVCRSGFRGARCEEVIPDEE 226
C GW N N C+ PCQN G+C C C+ GF+G C+ I +
Sbjct: 745 CDAGWVGINCEVDKNECLSN----PCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECA 800
Query: 227 FDP 229
+P
Sbjct: 801 SNP 803
Score = 35.8 bits (81), Expect = 0.39
Identities = 19/63 (30%), Positives = 31/63 (49%), Gaps = 5/63 (7%)
Query: 174 CPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQL---CVCRSGFRGARCEEVIPDEEFDPQ 230
CP T + + PC+N+G+C + + C+C SG+ GA C+ +P+ D
Sbjct: 1051 CPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCD--VPNVSCDIA 1108
Query: 231 NSR 233
SR
Sbjct: 1109 ASR 1111
Score = 34.7 bits (78), Expect = 0.87
Identities = 22/60 (36%), Positives = 24/60 (40%), Gaps = 11/60 (18%)
Query: 394 GFRIYFCQI--------PCLNGGRCIGRD---ECWCPANSTGKFCHLPIPQPDREPPGRG 442
GF CQI PCLNG +CI EC C TG C I D +P G
Sbjct: 523 GFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHG 582
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 5/58 (8%)
Query: 172 QC-CPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ----LCVCRSGFRGARCEEVIPD 224
QC CP T + P PC N G+C + C C GF G+ CE I D
Sbjct: 206 QCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDD 263
Score = 34.3 bits (77), Expect = 1.1
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 172 QCCPGWTTANSTNHCIKPVCEPPCQNRGSCS---RPQLCVCRSGFRGARCEEVIPD 224
+C PG+ N + + PCQN G+C C C G RG CEE I D
Sbjct: 1174 ECVPGYQGVNC-EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDD 1228
Score = 33.9 bits (76), Expect = 1.5
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 15/96 (15%)
Query: 355 FTPTICKQTCARGHCA-NSCERGDTTTLYSQGGHGHDPKSGFRIYFCQI--------PCL 405
+T + C++ CA N C+ G T + + GG+ + G++ C+ PC
Sbjct: 1141 YTGSYCEEQL--DECASNPCQHGATCSDFI-GGYRCECVPGYQGVNCEYEVDECQNQPCQ 1197
Query: 406 NGGRCI---GRDECWCPANSTGKFCHLPIPQPDREP 438
NGG CI +C CP + G C I R P
Sbjct: 1198 NGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGP 1233
Score = 33.5 bits (75), Expect = 1.9
Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 10/90 (11%)
Query: 145 LGTPQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVC--EPPCQNRGSCS 202
+ P GA T P L G+ +C C G+ A+ T + PC++ G C
Sbjct: 380 ISNPCHKGALCDTNP---LNGQYIC--TCPQGYKGADCTEDVDECAMANSNPCEHAGKCV 434
Query: 203 RPQ---LCVCRSGFRGARCEEVIPDEEFDP 229
C C G+ G RCE I + DP
Sbjct: 435 NTDGAFHCECLKGYAGPRCEMDINECHSDP 464
Score = 33.5 bits (75), Expect = 1.9
Identities = 20/59 (33%), Positives = 25/59 (42%), Gaps = 12/59 (20%)
Query: 172 QCCPGWT---TANSTNHCIKPVCEPPCQNRGSCSRPQL-----CVCRSGFRGARCEEVI 222
+C PG+ N C+ PC + GS QL CVCRS F G CE +
Sbjct: 1251 RCLPGFAGERCEGDINECLSN----PCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFV 1305
Score = 33.1 bits (74), Expect = 2.5
Identities = 16/39 (41%), Positives = 18/39 (46%), Gaps = 3/39 (7%)
Query: 403 PCLNGGRCI---GRDECWCPANSTGKFCHLPIPQPDREP 438
PCLN G C+ G C CP TGK C + R P
Sbjct: 1033 PCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSP 1071
Score = 32.3 bits (72), Expect = 4.3
Identities = 31/121 (25%), Positives = 46/121 (38%), Gaps = 37/121 (30%)
Query: 1728 GFEGLQAE----ECGILNGCENG-RCVRVREGYTCDCFEGFQ---LDAAHMACVD---VN 1776
GF G + E EC I C++G C+ + Y C C +GF D+ ++ C VN
Sbjct: 173 GFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVN 232
Query: 1777 ------------ECDDLNG-------------PAVLCVHG-YCENTEGSYRCHCSPGYVA 1810
EC+ L G P C +G C + +Y C C P +
Sbjct: 233 GGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTG 292
Query: 1811 E 1811
+
Sbjct: 293 Q 293
Score = 32.0 bits (71), Expect = 5.6
Identities = 14/33 (42%), Positives = 19/33 (57%), Gaps = 5/33 (15%)
Query: 400 CQIP--CLNGGRCI---GRDECWCPANSTGKFC 427
C IP C +GG C+ G +C CP TG++C
Sbjct: 186 CDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC 218
Score = 31.6 bits (70), Expect = 7.4
Identities = 17/51 (33%), Positives = 24/51 (47%), Gaps = 4/51 (7%)
Query: 172 QCCPGWTTANSTNHCIKPVCEPPCQNRGSCS---RPQLCVCRSGFRGARCE 219
+C PG++ + I PCQN GSC C+C GF G +C+
Sbjct: 898 ECPPGFSGMDCEED-IDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Score = 31.2 bits (69), Expect = 9.6
Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 6/86 (6%)
Query: 569 ELTTQEDCCGSVGAFWGVTLCAPCPPRPASPVIENG-QLECPQGYKRLNLTHCQ-DINEC 626
E T Q G + L PC + N +C G+ C+ D+NEC
Sbjct: 130 ECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQK---CETDVNEC 186
Query: 627 LTLGLCKDA-ECVNTRGSYLCTCRPG 651
G C+ C+N GSY C C G
Sbjct: 187 DIPGHCQHGGTCLNLPGSYQCQCPQG 212
Score = 31.2 bits (69), Expect = 9.6
Identities = 22/68 (32%), Positives = 27/68 (39%), Gaps = 20/68 (29%)
Query: 173 CCPGWTTANSTNHCIKPVCE--------PPCQNRGSC---SRPQLCVCRSGFRGARCEEV 221
C PG+T PVC+ PC N C C C +GF G CEE
Sbjct: 520 CPPGFTG---------PVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEEN 570
Query: 222 IPDEEFDP 229
I + + DP
Sbjct: 571 IDNCDPDP 578
Score = 31.2 bits (69), Expect = 9.6
Identities = 14/43 (32%), Positives = 20/43 (46%), Gaps = 3/43 (6%)
Query: 403 PCLNGGRCIGR---DECWCPANSTGKFCHLPIPQPDREPPGRG 442
PC N G C+ + +C CP+ G +C +P D RG
Sbjct: 1071 PCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRG 1113
Score = 31.2 bits (69), Expect = 9.6
Identities = 22/67 (32%), Positives = 26/67 (38%), Gaps = 14/67 (20%)
Query: 160 RGRLTGRNVCGGQC-CPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ------LCVCRSG 212
+G G +C CP S C PCQ+ GSC PQ C C
Sbjct: 1353 KGEQCVHTASGPRCFCP------SPRDCESGCASSPCQHGGSC-HPQRQPPYYSCQCAPP 1405
Query: 213 FRGARCE 219
F G+RCE
Sbjct: 1406 FSGSRCE 1412
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 255 bits (652), Expect = 2e-67
Identities = 177/486 (36%), Positives = 230/486 (47%), Gaps = 71/486 (14%)
Query: 887 DDNECLRDPCK-GKGRCINRVGSYSCFCYPGYTLATSGAT-------------------Q 926
D +ECL P + + CIN VGSY C C+PG++L G T
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 927 ECQDI------------NECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINE 973
E + N C+ G C C+ GS C C GY ++ G C+DINE
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCK-QVCSTVGGSAICSCFPGYAIMADGVSCEDINE 722
Query: 974 C-RHPGTCPDG-RCVNSPGSYTC---LACEEGYRGQSGSCVDVNEC-LTPGVCAHG-KCT 1026
C TC G CVN+ GS+ C L CE GY + G C DV+EC + C G C
Sbjct: 723 CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQ 782
Query: 1027 NLEGSFRCS----CEQGYEVTSDEKGCQDVDECASRAS-CPTGL-CLNTEGSFACS---- 1076
N +GSF C C G+ + E C D++EC S + C G C+NT GS+ C
Sbjct: 783 NTKGSFYCQARQRCMDGF-LQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL 841
Query: 1077 ACENGYWVNEDGTACEDLDECAFPGV--CPSG-VCTNTAGSFSCKDCDGGYRPSPLGDSC 1133
C GY ++DGT C D++EC GV C G VC N GS+ C DC G++ G C
Sbjct: 842 ICARGYHASDDGTKCVDVNECE-TGVHRCGEGQVCHNLPGSYRC-DCKAGFQRDAFGRGC 899
Query: 1134 EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGEC 1192
DV+EC C+NT+GSY+C C GF L A+G CEDVNEC + C+ EC
Sbjct: 900 IDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEA-QRCSQ--EC 956
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECAT-TDPCVGGHCVNTEGSFNCLC-ETGFQP 1250
N +GS+ C C G+ AE G +C D+DECA C+N GS+ C C E G+
Sbjct: 957 ANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTM 1016
Query: 1251 SPESGECVDIDECEDYGDPVCGTWK-CENSPGSYRCV-LGCQPGF-----HMAPNGDCID 1303
+ C D+DEC G C + C N GS+RC+ C P + C D
Sbjct: 1017 TANGRSCKDVDECA-LGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHD 1075
Query: 1304 IDECAN 1309
EC N
Sbjct: 1076 FLECQN 1081
Score = 248 bits (632), Expect = 5e-65
Identities = 195/596 (32%), Positives = 264/596 (44%), Gaps = 98/596 (16%)
Query: 693 KQICCCSRVG---KAWGSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEE-- 747
KQ C C +G +A G CE P G Y + + LS + EE
Sbjct: 516 KQCCDCCGLGLRVRAEGQSCESNPNLG---------------YPCNHVMLSCCEGEEPLI 560
Query: 748 --ELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKGDS---QAGQV----- 797
E+ RPP + A R+ L + T+ L D D G++
Sbjct: 561 VPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLC 620
Query: 798 --TTSVTHAPAWV-------------TGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLST 842
T H + G+ P P++ + + QV +T + L
Sbjct: 621 INTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNT---IPLPL 677
Query: 843 PGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRD--PCKG 898
P + C GP C + C C PGY + C D NEC+ D C
Sbjct: 678 PQPNTCKDN-----GPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSR 732
Query: 899 KGRCINRVGSYSCF----CYPGYTLATSGATQECQDINECEQ-PGVCSGG-QCTNTEGSY 952
C+N +GS+ C+ C PGY L EC+D++EC C G C NT+GS+
Sbjct: 733 GEHCVNTLGSFHCYKALTCEPGYALKDG----ECEDVDECAMGTHTCQPGFLCQNTKGSF 788
Query: 953 HCE----CDQGYIMVRKGHCQDINECRH-PGTC-PDGRCVNSPGSYTC----LACEEGYR 1002
+C+ C G++ +G+C DINEC C P C+N+ GSYTC L C GY
Sbjct: 789 YCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYH 848
Query: 1003 GQSG--SCVDVNECLTPGV--CAHGK-CTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC-A 1056
CVDVNEC T GV C G+ C NL GS+RC C+ G++ + +GC DV+EC A
Sbjct: 849 ASDDGTKCVDVNECET-GVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWA 907
Query: 1057 SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFS 1116
S C NT GS+ CS C +G+ + DG CED++EC S C N GS+
Sbjct: 908 SPGRLCQHTCENTLGSYRCS-CASGFLLAADGKRCEDVNECEAQRC--SQECANIYGSYQ 964
Query: 1117 CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCP-QGFQL-ANGTVC 1174
C C GY+ + G +C D+DEC C N GSYQC CP QG+ + ANG C
Sbjct: 965 CY-CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSC 1023
Query: 1175 EDVNEC-MGEEHCAPHGECLNSHGSFFCL---CAPGFVSAE----GGTSCQDVDEC 1222
+DV+EC +G +C+ C N GSF CL C P +V T+C D EC
Sbjct: 1024 KDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLEC 1079
Score = 247 bits (630), Expect = 9e-65
Identities = 171/470 (36%), Positives = 230/470 (48%), Gaps = 49/470 (10%)
Query: 930 DINECEQ-PGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
D +EC PG C NT GSYHC C G+ + G CR G P
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRT-----CRPEGHPPQPEAPQE 658
Query: 989 PGSYTCLACEEGYRGQSGSCVDV-----NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVT 1043
P A + + + + + + N C G C C+ + GS CSC GY +
Sbjct: 659 P------ALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQ-VCSTVGGSAICSCFPGYAIM 711
Query: 1044 SDEKGCQDVDECASRA-SCPTGL-CLNTEGSFACS---ACENGYWVNEDGTACEDLDECA 1098
+D C+D++EC + +C G C+NT GSF C CE GY + +DG CED+DECA
Sbjct: 712 ADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYAL-KDGE-CEDVDECA 769
Query: 1099 F-PGVCPSG-VCTNTAGSFSCKD---CDGGYRPSPLGDSCEDVDECEDPQSSCLGG-ECK 1152
C G +C NT GSF C+ C G+ P G+ C D++EC C G C
Sbjct: 770 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEPCRPGFSCI 828
Query: 1153 NTVGSYQC-----LCPQGFQLAN-GTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCLCAP 1205
NTVGSY C +C +G+ ++ GT C DVNEC G C C N GS+ C C
Sbjct: 829 NTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKA 888
Query: 1206 GFVSAEGGTSCQDVDECATTDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDIDECE 1264
GF G C DV+EC + + H C NT GS+ C C +GF + + C D++ECE
Sbjct: 889 GFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECE 948
Query: 1265 DYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTD 1323
C +C N GSY+C C+ G+ +A +G C DIDECA C N
Sbjct: 949 AQR---CSQ-ECANIYGSYQCY--CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVP 1002
Query: 1324 GSFRCLC-DQGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCL 1371
GS++C C +QG+ ++ +G C DV+EC L C A C N++GSF CL
Sbjct: 1003 GSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCL 1052
Score = 242 bits (618), Expect = 2e-63
Identities = 178/524 (33%), Positives = 239/524 (45%), Gaps = 82/524 (15%)
Query: 815 PPMPEQGIAEIQE------EQVTPSTDVLVTLSTPGIDR--CAAGATNVCGPGTCVNLPD 866
PP P + E E ++ T+ + S PG D+ C +C C+N
Sbjct: 567 PPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELC-QHLCINTVG 625
Query: 867 GYRCVCSPGYQLHPSQAYCTDDN-----ECLRDP-----------------------CKG 898
Y C C PG+ L C + E ++P CK
Sbjct: 626 SYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD 685
Query: 899 KGRCINRV----GSYSCFCYPGYTLATSGATQECQDINEC-EQPGVCSGGQ-CTNTEGSY 952
G C GS C C+PGY + G + C+DINEC CS G+ C NT GS+
Sbjct: 686 NGPCKQVCSTVGGSAICSCFPGYAIMADGVS--CEDINECVTDLHTCSRGEHCVNTLGSF 743
Query: 953 HC----ECDQGYIMVRKGHCQDINEC-RHPGTCPDG-RCVNSPGSYTCLA---CEEGY-R 1002
HC C+ GY + + G C+D++EC TC G C N+ GS+ C A C +G+ +
Sbjct: 744 HCYKALTCEPGYAL-KDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQ 802
Query: 1003 GQSGSCVDVNECLT-PGVCAHG-KCTNLEGSFRCS-----CEQGYEVTSDEKGCQDVDEC 1055
G+CVD+NEC + C G C N GS+ C C +GY + D C DV+EC
Sbjct: 803 DPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNEC 862
Query: 1056 ASRA-SCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDEC-AFPGVCPSGVCTNTA 1112
+ C G +C N GS+ C C+ G+ + G C D++EC A PG C NT
Sbjct: 863 ETGVHRCGEGQVCHNLPGSYRCD-CKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTL 921
Query: 1113 GSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLA-NG 1171
GS+ C C G+ + G CEDV+ECE + S EC N GSYQC C QG+QLA +G
Sbjct: 922 GSYRC-SCASGFLLAADGKRCEDVNECEAQRCS---QECANIYGSYQCYCRQGYQLAEDG 977
Query: 1172 TVCEDVNECMGEEHCAPHGECLNSHGSFFCLC-APGFVSAEGGTSCQDVDECAT-TDPCV 1229
C D++EC CLN GS+ C C G+ G SC+DVDECA T C
Sbjct: 978 HTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCS 1037
Query: 1230 GGH-CVNTEGSFNCL---CETGF----QPSPESGECVDIDECED 1265
C N +GSF CL C + + E C D EC++
Sbjct: 1038 EAETCHNIQGSFRCLRFECPPNYVQVSKTKCERTTCHDFLECQN 1081
Score = 222 bits (565), Expect = 3e-57
Identities = 219/796 (27%), Positives = 303/796 (38%), Gaps = 169/796 (21%)
Query: 744 AEEEELARPPREQ----------GQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKG--- 790
+EEEE RE+ G R LP A P + + EAG + G
Sbjct: 277 SEEEEEEEEEREEMAVTEQLAAGGHRGLDGLPTTAPAGPSLPIQEERAEAGARAEAGARP 336
Query: 791 ------DSQAGQVTTS---VTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLS 841
D+QA +T VTHAP+ G A +P Q + + V PS +++ S
Sbjct: 337 EENLILDAQATSRSTGPEGVTHAPS--LGKAAL--VPTQAVPGSPRDPVKPSPHNILSTS 392
Query: 842 TPGIDRCA--------------AGATNVCGPGTCVNLP---------DGYRCVCSPGYQL 878
P + P + ++P D C+ G Q
Sbjct: 393 LPDAAWIPPTREVPRKPQVLPHSHVEEDTDPNSVHSIPRSSPEGSTKDLIETCCAAGQQ- 451
Query: 879 HPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCF--------CYPGYTLATSGATQECQD 930
+ D++ECL P G + R C C G A G T +D
Sbjct: 452 -----WAIDNDECLEIPESGTEDNVCRTAQRHCCVSYLQEKSCMAGVLGAKEGETCGAED 506
Query: 931 INECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR-KGHCQDINE-----CRH-------- 976
+ C G+ QC C+C + VR +G + N C H
Sbjct: 507 NDSC---GISLYKQC--------CDCCGLGLRVRAEGQSCESNPNLGYPCNHVMLSCCEG 555
Query: 977 --PGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCV-------------DVNECLT-PGVC 1020
P P+ R P + E G+ + D +ECL PG
Sbjct: 556 EEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGEL 615
Query: 1021 AHGKCTNLEGSFRCSCEQGYEVTSDEKGCQ------------------------------ 1050
C N GS+ C+C G+ + D + C+
Sbjct: 616 CQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL 675
Query: 1051 ---DVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP-GVCPSG 1106
+ C C +C GS CS C GY + DG +CED++EC C G
Sbjct: 676 PLPQPNTCKDNGPCKQ-VCSTVGGSAICS-CFPGYAIMADGVSCEDINECVTDLHTCSRG 733
Query: 1107 V-CTNTAGSFSCKD---CDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTVGSYQCL 1161
C NT GSF C C+ GY CEDVDEC +C G C+NT GS+ C
Sbjct: 734 EHCVNTLGSFHCYKALTCEPGYALKD--GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQ 791
Query: 1162 ----CPQGFQLANGTVCEDVNECMG-EEHCAPHGECLNSHGSFFC-----LCAPGFVSAE 1211
C GF C D+NEC E C P C+N+ GS+ C +CA G+ +++
Sbjct: 792 ARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASD 851
Query: 1212 GGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDP 1269
GT C DV+EC T C G C N GS+ C C+ GFQ C+D++EC
Sbjct: 852 DGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGR 911
Query: 1270 VCGTWKCENSPGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRC 1328
+C CEN+ GSYRC C GF +A +G C D++EC C C N GS++C
Sbjct: 912 LC-QHTCENTLGSYRC--SCASGFLLAADGKRCEDVNECEAQR-CSQE--CANIYGSYQC 965
Query: 1329 LCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR- 1387
C QG++++ G C D++EC + C NV GS+ C C A C+
Sbjct: 966 YCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD 1025
Query: 1388 --PRGAGGQSMSEAPT 1401
G + SEA T
Sbjct: 1026 VDECALGTHNCSEAET 1041
Score = 147 bits (370), Expect = 1e-34
Identities = 183/699 (26%), Positives = 242/699 (34%), Gaps = 153/699 (21%)
Query: 993 TCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDV 1052
TC A + + + C+++ E T C + S Q + G ++
Sbjct: 444 TCCAAGQQWAIDNDECLEIPESGTED----NVCRTAQRHCCVSYLQEKSCMAGVLGAKEG 499
Query: 1053 DECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTA 1112
+ C + + G+ L + C C G V +G +CE +P C +
Sbjct: 500 ETCGAEDNDSCGISLYKQ---CCDCCGLGLRVRAEGQSCESNPNLGYP-------CNHVM 549
Query: 1113 GSFSCKDCDGGY--------RPSPLGDSCEDVDECE---------------------DPQ 1143
SC C+G RP + V E E D Q
Sbjct: 550 --LSC--CEGEEPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQ 605
Query: 1144 SSCL--GGE-----CKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHC----APHGEC 1192
CL GE C NTVGSY C C GF L +D C E H AP
Sbjct: 606 DECLLLPGELCQHLCINTVGSYHCACFPGFSLQ-----DDGRTCRPEGHPPQPEAPQEPA 660
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252
L S S + T C+D C VGG + C C G+
Sbjct: 661 LKSEFSQVASNTIPLPLPQPNT-CKDNGPCKQVCSTVGGSAI-------CSCFPGYAIMA 712
Query: 1253 ESGECVDIDECEDYGDPVCGTWKCENSPGSYRC--VLGCQPGFHMAPNGDCIDIDECAND 1310
+ C DI+EC C N+ GS+ C L C+PG+ + +G+C D+DECA
Sbjct: 713 DGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-DGECEDVDECAMG 771
Query: 1311 TMCGSHGF-CDNTDGSFRCL----CDQGFEISPSGWDCVDVNECELMLAVCGAAL-CENV 1364
T GF C NT GSF C C GF P G +CVD+NEC + C C N
Sbjct: 772 THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINT 830
Query: 1365 EGSFLC-----LCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG 1419
GS+ C +CA H G ++E TG H C GQ
Sbjct: 831 VGSYTCQRNPLICARGY--------HASDDGTKCVDVNECETGVHR-------CGEGQVC 875
Query: 1420 HAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFG 1479
H S C C G DA G+G I V W
Sbjct: 876 HNLPGSY--------RCDCKAGFQ-RDAF-----------------GRGCIDVNECWA-- 907
Query: 1480 QTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN 1539
PG C NT+ Y C C GF A K+CED +EC+ C
Sbjct: 908 -------------SPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQ 954
Query: 1540 GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDI-CWKKVTNDVCSEP 1598
EC N GS+ C+C L C T E I C + C+ P
Sbjct: 955 -ECANIYGSYQCYCRQGYQLAEDGHTC---TDIDECAQGAGILCTFRCLNVPGSYQCACP 1010
Query: 1599 LRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCN 1637
+G+ T C+D + +CAL SE A+ C+
Sbjct: 1011 EQGYTMTANGRSCKDVD----ECALGTHNCSE--AETCH 1043
Score = 69.3 bits (168), Expect = 3e-11
Identities = 38/90 (42%), Positives = 45/90 (50%), Gaps = 11/90 (12%)
Query: 1736 ECGILNGCENGR--------CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL 1787
+C +N CE G C + Y CDC GFQ DA C+DVNEC P L
Sbjct: 855 KCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNEC--WASPGRL 912
Query: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
C H CENT GSYRC C+ G++ A C
Sbjct: 913 CQH-TCENTLGSYRCSCASGFLLAADGKRC 941
Score = 53.5 bits (127), Expect = 2e-06
Identities = 76/317 (23%), Positives = 109/317 (34%), Gaps = 56/317 (17%)
Query: 1527 EDHDECQDLACENGE--CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMD 1584
+D DEC L E + C+NT GS+HC C P +L + C + + +
Sbjct: 603 DDQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662
Query: 1585 ICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAE 1644
+ +V ++ PL T C+D Q C S+ + +C+ A
Sbjct: 663 SEFSQVASNTIPLPLPQPNT------CKDNGPCKQVC------STVGGSAICSCFPGYAI 710
Query: 1645 REAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGP----EDTVPEPAFPNTAGHSAD 1700
GV + DLH G N LG + EP + G D
Sbjct: 711 MADGVSCE---DINECVTDLHTCSRGEHCV---NTLGSFHCYKALTCEPGYALKDGECED 764
Query: 1701 RTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVRE------- 1753
+ E + QP ++ + + + Q G L E G CV + E
Sbjct: 765 ---VDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE-GNCVDINECTSLSEP 820
Query: 1754 ------------GYTCD-----CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG-YCEN 1795
YTC C G+ CVDVNEC+ C G C N
Sbjct: 821 CRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECET---GVHRCGEGQVCHN 877
Query: 1796 TEGSYRCHCSPGYVAEA 1812
GSYRC C G+ +A
Sbjct: 878 LPGSYRCDCKAGFQRDA 894
Score = 52.4 bits (124), Expect = 4e-06
Identities = 48/161 (29%), Positives = 63/161 (39%), Gaps = 35/161 (21%)
Query: 519 PGHSLWDSNNIPARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQED--- 575
PG SL D G PP+P P P + + NT+ PL + T +D
Sbjct: 633 PGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTI----PLPLPQPNTCKDNGP 688
Query: 576 ---CCGSVGAFWGVTLCAPCPPRPASPVIENGQLECPQGYKRLNLTHCQDINECLT-LGL 631
C +VG A C P ++ +G C+DINEC+T L
Sbjct: 689 CKQVCSTVGG------SAICSCFPGYAIMADG-------------VSCEDINECVTDLHT 729
Query: 632 CKDAE-CVNTRGSYLC----TCRPGLMLDPSRSRCVSDKAI 667
C E CVNT GS+ C TC PG L V + A+
Sbjct: 730 CSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAM 770
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/88 (34%), Positives = 39/88 (44%), Gaps = 8/88 (9%)
Query: 1735 EECGILNGCENGRC----VRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790
+ C +N CE RC + Y C C +G+QL C D++EC G +LC
Sbjct: 939 KRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDEC--AQGAGILCTF 996
Query: 1791 GYCENTEGSYRCHC-SPGYVAEAGPPHC 1817
C N GSY+C C GY A C
Sbjct: 997 -RCLNVPGSYQCACPEQGYTMTANGRSC 1023
Score = 48.5 bits (114), Expect = 6e-05
Identities = 31/84 (36%), Positives = 43/84 (51%), Gaps = 15/84 (17%)
Query: 1741 NGC-ENGRCVRVRE----GYTCDCFEGFQLDAAHMACVDVNEC-DDLNGPAVLCVHG-YC 1793
N C +NG C +V C CF G+ + A ++C D+NEC DL+ C G +C
Sbjct: 681 NTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLH----TCSRGEHC 736
Query: 1794 ENTEGSYRCH----CSPGYVAEAG 1813
NT GS+ C+ C PGY + G
Sbjct: 737 VNTLGSFHCYKALTCEPGYALKDG 760
Score = 48.5 bits (114), Expect = 6e-05
Identities = 32/85 (37%), Positives = 39/85 (45%), Gaps = 10/85 (11%)
Query: 1732 LQAEECGILNG--CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCV 1789
+ EC G C++ C Y C C GF L A C DVNEC+ A C
Sbjct: 900 IDVNECWASPGRLCQH-TCENTLGSYRCSCASGFLLAADGKRCEDVNECE-----AQRCS 953
Query: 1790 HGYCENTEGSYRCHCSPGY-VAEAG 1813
C N GSY+C+C GY +AE G
Sbjct: 954 Q-ECANIYGSYQCYCRQGYQLAEDG 977
Score = 42.7 bits (99), Expect = 0.003
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 1735 EECGI-LNGCENG-RCVRVREGYTCD----CFEGFQLDAAHMACVDVNECDDLNGPAVLC 1788
+EC + + C+ G C + + C C +GF D CVD+NEC L+ P C
Sbjct: 766 DECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGN-CVDINECTSLSEP---C 821
Query: 1789 VHGY-CENTEGSYRCH-----CSPGYVAEAGPPHC 1817
G+ C NT GSY C C+ GY A C
Sbjct: 822 RPGFSCINTVGSYTCQRNPLICARGYHASDDGTKC 856
Score = 41.6 bits (96), Expect = 0.007
Identities = 35/139 (25%), Positives = 51/139 (36%), Gaps = 14/139 (10%)
Query: 587 TLCAPCPP------RPASPVIENGQLECPQGYKRLNL-THCQDINECLT-LGLCKDAE-C 637
+L PC P S + L C +GY + T C D+NEC T + C + + C
Sbjct: 816 SLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVC 875
Query: 638 VNTRGSYLCTCRPGLMLDPSRSRCVSDKAI-----SMLQGLCYRSLGPGTCTLPLAQRIT 692
N GSY C C+ G D C+ + Q C +LG C+ +
Sbjct: 876 HNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLA 935
Query: 693 KQICCCSRVGKAWGSECEK 711
C V + C +
Sbjct: 936 ADGKRCEDVNECEAQRCSQ 954
Score = 41.6 bits (96), Expect = 0.007
Identities = 28/84 (33%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 1737 CGILNGCENG-------RCVRVREGYTCDCFE-GFQLDAAHMACVDVNECDDLNGPAVLC 1788
C ++ C G RC+ V Y C C E G+ + A +C DV+EC G
Sbjct: 980 CTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDEC--ALGTHNCS 1037
Query: 1789 VHGYCENTEGSYRC---HCSPGYV 1809
C N +GS+RC C P YV
Sbjct: 1038 EAETCHNIQGSFRCLRFECPPNYV 1061
Score = 36.6 bits (83), Expect = 0.23
Identities = 22/72 (30%), Positives = 27/72 (37%), Gaps = 7/72 (9%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGL-----C 674
C+D+NEC + EC N GSY C CR G L C + G+ C
Sbjct: 941 CEDVNECEAQRCSQ--ECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRC 998
Query: 675 YRSLGPGTCTLP 686
G C P
Sbjct: 999 LNVPGSYQCACP 1010
Score = 35.0 bits (79), Expect = 0.67
Identities = 19/42 (45%), Positives = 22/42 (52%), Gaps = 3/42 (7%)
Query: 622 DINECLTLG--LCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
D +ECL L LC+ C+NT GSY C C PG L C
Sbjct: 604 DQDECLLLPGELCQHL-CINTVGSYHCACFPGFSLQDDGRTC 644
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 247 bits (630), Expect = 9e-65
Identities = 290/1067 (27%), Positives = 394/1067 (36%), Gaps = 250/1067 (23%)
Query: 831 TPSTDVLVTLSTPGI--DRCAAGATNVCGPGTC-------VNLPDGYRCVCSPGYQLHPS 881
+P T + PG +RC A + C P C + +C C PG+ +
Sbjct: 95 SPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGW----T 150
Query: 882 QAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINEC-EQPGVC 940
C + C +PC G C+ C C PG+ G E +D+NEC + PG C
Sbjct: 151 GEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGF----EGHACE-RDVNECFQDPGPC 205
Query: 941 -SGGQCTNTEGSYHCECDQGY----IMVRKGHCQDINECRHPGTC--------------- 980
G C NT GS+ C C G +R G C C + GTC
Sbjct: 206 PKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPP-RGCSNGGTCQLMPEKDSTFHLCLC 264
Query: 981 ------PD----------------GRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPG 1018
PD G C + +YTCL C E + G S DV+EC T G
Sbjct: 265 PPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCL-CPETWTGWDCS-EDVDECETQG 322
Query: 1019 V--CAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFAC 1075
C + G C N GSF C C G+ TS E +++D+C + P C++ GSF+C
Sbjct: 323 PPHCRNGGTCQNSAGSFHCVCVSGWGGTSCE---ENLDDCIAATCAPGSTCIDRVGSFSC 379
Query: 1076 SACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNT--AGSFSCKDCDGGYRPSPLGDSC 1133
C G G C D C C+ GS C C GY G +C
Sbjct: 380 -LCPPG----RTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCL-CQPGYS----GPTC 429
Query: 1134 -EDVDEC----EDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCA 1187
+D+DEC + P GG C NT GS+ CLCP G+ G+ CE D NEC+ + C
Sbjct: 430 HQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY---TGSRCEADHNECLSQP-CH 485
Query: 1188 PHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG-GHCVNTEGSFNCLCET 1246
P CL+ +F CLC PG EG + +ECA+ PC+ C + F C+C
Sbjct: 486 PGSTCLDLLATFHCLCPPGL---EGQLCEVETNECASA-PCLNHADCHDLLNGFQCICLP 541
Query: 1247 GFQPSPESGEC-VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDID 1305
GF + C DIDEC P +C++ PG++ C C PGF P ++D
Sbjct: 542 GFSGT----RCEEDIDECR--SSPCANGGQCQDQPGAFHC--KCLPGFE-GPRCQ-TEVD 591
Query: 1306 ECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVE 1365
EC +D C C + G+F CLC GF LCE
Sbjct: 592 ECLSDP-CPVGASCLDLPGAFFCLCPSGFT----------------------GQLCE--- 625
Query: 1366 GSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA----PTGDHAPAPTRMDCYSGQKGHA 1421
+ LCA +L C+P+ +A P G AP +C + GH
Sbjct: 626 ---VPLCAPNL---------CQPKQICKDQKDKANCLCPDGSPGCAPPEDNC-TCHHGHC 672
Query: 1422 PCSSVLGRNTTQAECCCTQGASWGDACDL----CPSEDSAEFSEICPSGKGYIPVEGAWT 1477
SS C C G + G C+ C S A P GY
Sbjct: 673 QRSS----------CVCDVGWT-GPECEAELGGCISAPCAHGGTCYPQPSGY---NCTCP 718
Query: 1478 FGQTMYTDADECVIFGPGLCPNGRCLNTVP-GYVCLCNPGFHYDASHKKCE-DHDECQDL 1535
G T T ++E G C NG N P GY C C P + +C+ D C
Sbjct: 719 TGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH----TGPQCQTSTDYCVSA 774
Query: 1536 ACEN-GECVNTEGSFHCFCSPPLTLDLSQQRCMNS-TSSTEDLPDHDIHMDICWKKVTND 1593
C N G CVN G+F C C+ + RC S D P C + T
Sbjct: 775 PCFNGGTCVNRPGTFSCLCA----MGFQGPRCEGKLRPSCADSP--------CRNRAT-- 820
Query: 1594 VCSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRP 1653
C + +G R C C G S + LC A++
Sbjct: 821 -CQDSPQGPR-----CLCPTGYTGG---------SCQTLMDLC------AQK-------- 851
Query: 1654 GYEYGPGPDDLHYSIYGPD--GAPFYNYLGPEDTVPEPAFPNTA-GHSADRTPILESPLQ 1710
P P + H GP + GP +P + A D + + +
Sbjct: 852 -----PCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGL 906
Query: 1711 PSELQPHYVASHPEPPAGFEGLQAEECGILNGCEN------GRCVRVREGYTCDCFEGF- 1763
+ P Y P GF+G ++ +N CE+ C+ GY C C G+
Sbjct: 907 CVDSGPSYFC---HCPPGFQGSLCQD--HVNPCESRPCQNGATCMAQPSGYLCQCAPGYD 961
Query: 1764 -QLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYV 1809
Q + + C + HG C G + C C PG+V
Sbjct: 962 GQNCSKELDACQSQPCHN---------HGTCTPKPGGFHCACPPGFV 999
Score = 231 bits (588), Expect = 6e-60
Identities = 243/852 (28%), Positives = 340/852 (39%), Gaps = 156/852 (18%)
Query: 859 GTCVNLPDG----YRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCY 914
GTC +P+ + C+C PG+ + P D+ C+ C+ G C + + +Y+C C
Sbjct: 247 GTCQLMPEKDSTFHLCLCPPGF-IGPDCEVNPDN--CVSHQCQNGGTCQDGLDTYTCLCP 303
Query: 915 PGYTLATSGATQEC-QDINECEQPGV--C-SGGQCTNTEGSYHCECDQGYIMVRKGHCQD 970
+T +C +D++ECE G C +GG C N+ GS+HC C G+ C++
Sbjct: 304 ETWT------GWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGW---GGTSCEE 354
Query: 971 -INECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTN-- 1027
+++C P C++ GS++CL C G G D+ CL+ +C+
Sbjct: 355 NLDDCIAATCAPGSTCIDRVGSFSCL-CPPGRTGLLCHLEDM--CLSQPCHGDAQCSTNP 411
Query: 1028 LEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPT-----GLCLNTEGSFACSACENGY 1082
L GS C C+ GY S QD+DEC P+ G CLNT GSF C C GY
Sbjct: 412 LTGSTLCLCQPGY---SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC-LCPPGY 467
Query: 1083 WVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECED 1141
G+ CE D +EC P C + +F C C G G CE V+ E
Sbjct: 468 ----TGSRCEADHNECLSQPCHPGSTCLDLLATFHCL-CPPGLE----GQLCE-VETNEC 517
Query: 1142 PQSSCLG-GECKNTVGSYQCLCPQGFQLANGTVCE-DVNECMGEEHCAPHGECLNSHGSF 1199
+ CL +C + + +QC+C GF +GT CE D++EC CA G+C + G+F
Sbjct: 518 ASAPCLNHADCHDLLNGFQCICLPGF---SGTRCEEDIDECRSSP-CANGGQCQDQPGAF 573
Query: 1200 FCLCAPGFVSAEGGTSCQ-DVDECATTDPC-VGGHCVNTEGSFNCLCETGFQ------PS 1251
C C PGF G CQ +VDEC + DPC VG C++ G+F CLC +GF P
Sbjct: 574 HCKCLPGFE----GPRCQTEVDECLS-DPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPL 628
Query: 1252 PESGECVDIDECEDYGDP---VC--GTWKCENSPGSYRCVLG-CQPGFHMAPNG----DC 1301
C C+D D +C G+ C + C G CQ + G +C
Sbjct: 629 CAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPEC 688
Query: 1302 -IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGF-----------------------EIS 1337
++ C + C G C + C C G+ S
Sbjct: 689 EAELGGCIS-APCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPS 747
Query: 1338 PSGWDCV-----DVNECELMLAVCGAA------LCENVEGSFLCLCASDLEEYDAQEGHC 1386
P G+ C +C+ C +A C N G+F CLCA + EG
Sbjct: 748 PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRC-EGKL 806
Query: 1387 RPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHA-----------PC--SSVLGRNTTQ 1433
RP A + A D P R C +G G + PC +S +
Sbjct: 807 RPSCADSPCRNRATCQDSPQGP-RCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPS 865
Query: 1434 AECCCTQGASWGDACDLCPSE-------DSAEFSEICPSGKGYIPVEGAWTF-------- 1478
C C QG + G C+L S + S +C +G G G F
Sbjct: 866 FHCLCLQGWT-GPLCNLPLSSCQKAALSQGIDVSSLCHNG-GLCVDSGPSYFCHCPPGFQ 923
Query: 1479 GQTMYTDADECVIFGPGLCPNGR-CLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLAC 1537
G + C C NG C+ GY+C C PG+ K+ D CQ C
Sbjct: 924 GSLCQDHVNPCE---SRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKEL---DACQSQPC 977
Query: 1538 EN-GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCS 1596
N G C G FHC C PP + L RC D P H C + N
Sbjct: 978 HNHGTCTPKPGGFHCAC-PPGFVGL---RCEGDVDECLDQPCHPTGTAAC-HSLANAFYC 1032
Query: 1597 EPLRGHRTTYTE 1608
+ L GH + E
Sbjct: 1033 QCLPGHTGQWCE 1044
Score = 221 bits (562), Expect = 7e-57
Identities = 268/1017 (26%), Positives = 362/1017 (35%), Gaps = 188/1017 (18%)
Query: 605 QLECPQGYKRLNLTHCQDINECLT-LGLC-KDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
Q CP G++ +D+NEC G C K C NT GS+ C C G RC
Sbjct: 179 QCHCPPGFEGHACE--RDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVG----QEGPRCE 232
Query: 663 SDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCP--------- 713
+G GTC L + T +C C G +CE P
Sbjct: 233 LRAGPCPPRGCS----NGGTCQLMPEKDSTFHLCLCPP--GFIGPDCEVNPDNCVSHQCQ 286
Query: 714 -----LPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPP--REQG--QRSSGAL 764
G + + +CP S D+ +E E PP R G Q S+G+
Sbjct: 287 NGGTCQDGLDTYTCLCPETWTGWDCSEDV-------DECETQGPPHCRNGGTCQNSAGSF 339
Query: 765 PGPAERQPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAE 824
V W + D A T + + PP +
Sbjct: 340 HC--------VCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCH 391
Query: 825 IQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAY 884
+++ + LS P C A P T L C+C PGY S
Sbjct: 392 LED----------MCLSQP----CHGDAQCSTNPLTGSTL-----CLCQPGY----SGPT 428
Query: 885 CTDD-NECLR-----DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPG 938
C D +ECL PC+ G C+N GS++C C PGYT + A D NEC
Sbjct: 429 CHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEA-----DHNECLSQP 483
Query: 939 VCSGGQCTNTEGSYHCECDQGYIMVRKGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLAC 997
G C + ++HC C G + C+ + NEC C + + C+ C
Sbjct: 484 CHPGSTCLDLLATFHCLCPPG---LEGQLCEVETNECASAPCLNHADCHDLLNGFQCI-C 539
Query: 998 EEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQ-DVDECA 1056
G+ G D++EC + G+C + G+F C C G+E CQ +VDEC
Sbjct: 540 LPGFSGTRCE-EDIDECRSSPCANGGQCQDQPGAFHCKCLPGFE----GPRCQTEVDECL 594
Query: 1057 SRASCPTGL-CLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVC-PSGVCTNTAGS 1114
S CP G CL+ G+F C C +G+ G CE + CA P +C P +C +
Sbjct: 595 S-DPCPVGASCLDLPGAFFC-LCPSGF----TGQLCE-VPLCA-PNLCQPKQICKDQKDK 646
Query: 1115 FSCKDCDGGYRPSPLGDSCE-------------DV----DECEDPQSSCL------GGEC 1151
+C DG +P D+C DV ECE C+ GG C
Sbjct: 647 ANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTC 706
Query: 1152 KNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAE 1211
Y C CP G+ G C + C G C S G ++C C P +
Sbjct: 707 YPQPSGYNCTCPTGY---TGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPP----SH 759
Query: 1212 GGTSCQDVDECATTDPCV-GGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPV 1270
G CQ + + PC GG CVN G+F+CLC GFQ G+ C D P
Sbjct: 760 TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKL--RPSCAD--SPC 815
Query: 1271 CGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLC 1330
C++SP RC+ C G+ G C + + C + C T SF CLC
Sbjct: 816 RNRATCQDSPQGPRCL--CPTGY---TGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLC 870
Query: 1331 DQGFEISPSGWDCVDVNECELMLAVC-GAALCENVEGSFLC----LCASDLEEYDAQEGH 1385
QG+ P C L L+ C AAL + ++ S LC LC Y H
Sbjct: 871 LQGW-TGPL---------CNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFC---H 917
Query: 1386 CRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWG 1445
C P G + P C + G+ C C G G
Sbjct: 918 CPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYL--------------CQCAPGYD-G 962
Query: 1446 DAC----DLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGR 1501
C D C S+ P G+ G D DEC+
Sbjct: 963 QNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAA 1022
Query: 1502 CLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLAC-ENGECVNTEGS---FHCFC 1553
C + + C C PG + + CE + D C C G C T GS F C C
Sbjct: 1023 CHSLANAFYCQCLPGH----TGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHC 1075
Score = 176 bits (446), Expect = 2e-43
Identities = 258/935 (27%), Positives = 344/935 (36%), Gaps = 195/935 (20%)
Query: 974 CRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG-KC------- 1025
C + GTC S G TC C G+ G++ C + C +C +G C
Sbjct: 35 CANGGTCLS----LSLGQGTC-QCAPGFLGET--CQFPDPCQNAQLCQNGGSCQALLPAP 87
Query: 1026 -------TNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLC-LNTEGSFACSA 1077
+ L SF C+C G+ T + + D C G C + G CS
Sbjct: 88 LGLPSSPSPLTPSFLCTCLPGF--TGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCS- 144
Query: 1078 CENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DV 1136
C G+ G C+ D C+ GVC T C C G+ G +CE DV
Sbjct: 145 CMPGW----TGEQCQLRDFCSANPCVNGGVCLATYPQIQCH-CPPGFE----GHACERDV 195
Query: 1137 DEC-EDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGEC--L 1193
+EC +DP G C NT+GS+QCLCP G G CE C+ G C +
Sbjct: 196 NECFQDPGPCPKGTSCHNTLGSFQCLCPVG---QEGPRCELRAGPCPPRGCSNGGTCQLM 252
Query: 1194 NSHGSFF--CLCAPGFVSAEGGTSCQ-DVDECATTDPCVGGHCVNTEGSFNCLCE---TG 1247
S F CLC PGF+ G C+ + D C + GG C + ++ CLC TG
Sbjct: 253 PEKDSTFHLCLCPPGFI----GPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTG 308
Query: 1248 FQPSPESGECVDIDECEDYGDPVC---GTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDI 1304
+ S D+DECE G P C GT C+NS GS+ CV C G+ + ++
Sbjct: 309 WDCSE------DVDECETQGPPHCRNGGT--CQNSAGSFHCV--CVSGWGGTSCEE--NL 356
Query: 1305 DECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCEN- 1363
D+C T C C + GSF CLC G +G C + C L G A C
Sbjct: 357 DDCIAAT-CAPGSTCIDRVGSFSCLCPPG----RTGLLCHLEDMC-LSQPCHGDAQCSTN 410
Query: 1364 -VEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRM--DCYSGQKGH 1420
+ GS LCLC Q G+ P Q + E P+P C + G
Sbjct: 411 PLTGSTLCLC---------QPGYSGP--TCHQDLDECLMAQQGPSPCEHGGSCLN-TPGS 458
Query: 1421 APCSSVLGRNTTQAEC----CCTQGASWGDAC-DLCPSEDSAEFSEICPSGKGYIPVEGA 1475
C G ++ E C +Q G C DL A F +CP G
Sbjct: 459 FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLL-----ATFHCLCPPG--------- 504
Query: 1476 WTFGQTMYTDADECVIFGPGLCPN-GRCLNTVPGYVCLCNPGFHYDASHKKC-EDHDECQ 1533
GQ + +EC C N C + + G+ C+C PGF S +C ED DEC+
Sbjct: 505 -LEGQLCEVETNEC---ASAPCLNHADCHDLLNGFQCICLPGF----SGTRCEEDIDECR 556
Query: 1534 DLACEN-GECVNTEGSFHCFCSPPLTLDLSQ---QRCMNST----SSTEDLPDHDIHMDI 1585
C N G+C + G+FHC C P Q C++ +S DLP +
Sbjct: 557 SSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLP--GAFFCL 614
Query: 1586 CWKKVTNDVCSEPLRG-----------HRTTYTECCCQDGE---AWSQQCALCPPRSSEV 1631
C T +C PL + C C DG A + C +
Sbjct: 615 CPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQR 674
Query: 1632 YAQLCNVARI--EAEREAGVHFRPGYEYGPG--PDDLHYSIYGPDGAPFYNYLGPEDTVP 1687
+ +C+V E E E G +G P Y+ P G Y GP T
Sbjct: 675 SSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTG-----YTGP--TCS 727
Query: 1688 EPAFPNTAGHSADRTPILE-SPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCEN- 1745
E TA HS P L PS Y + P G + + + + C N
Sbjct: 728 EEM---TACHSG---PCLNGGSCNPS--PGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNG 779
Query: 1746 GRCVRVREGYTCDCFEGFQ---------LDAAHMACVDVNECDDL-NGPAVLCVHGY--- 1792
G CV ++C C GFQ A C + C D GP LC GY
Sbjct: 780 GTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGG 839
Query: 1793 -------------------CENTEGSYRCHCSPGY 1808
C T S+ C C G+
Sbjct: 840 SCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGW 874
Score = 154 bits (388), Expect = 1e-36
Identities = 225/828 (27%), Positives = 293/828 (35%), Gaps = 164/828 (19%)
Query: 590 APCPPRPASPVIENG-QLECPQGYKRLNLTHCQ-DINECLTLGLCKDAECVNTRGSYLCT 647
APC + NG Q C G+ T C+ DI+EC + +C + G++ C
Sbjct: 520 APCLNHADCHDLLNGFQCICLPGFSG---TRCEEDIDECRSSPCANGGQCQDQPGAFHCK 576
Query: 648 CRPGL---MLDPSRSRCVSDK-----AISMLQG----LCYRSLGPGTCTLPLAQRITKQI 695
C PG C+SD + L G LC C +PL +
Sbjct: 577 CLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLC---APNL 633
Query: 696 CCCSRVGKAWGSECE-KCP--LPGTEAFREICPAGHGYTYASS---DIRLSMRKAEEEE- 748
C ++ K + CP PG + C HG+ SS D+ + + E E
Sbjct: 634 CQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELG 693
Query: 749 --LARPPREQGQRSSGALPGPAERQ---PLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTH 803
++ P G P P+ P T E T G G S
Sbjct: 694 GCISAPCAHGGT----CYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGG---SCNP 746
Query: 804 APAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVN 863
+P G T P G Q STD V S P C G GTCVN
Sbjct: 747 SPG---GYYCTCPPSHTG------PQCQTSTDYCV--SAP----CFNG-------GTCVN 784
Query: 864 LPDGYRCVCSPGYQ-------LHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPG 916
P + C+C+ G+Q L PS C PC+ + C + C C G
Sbjct: 785 RPGTFSCLCAMGFQGPRCEGKLRPS---------CADSPCRNRATCQDSPQGPRCLCPTG 835
Query: 917 YTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYI----MVRKGHCQ--- 969
YT G+ Q D+ C Q C T S+HC C QG+ + CQ
Sbjct: 836 YT---GGSCQTLMDL--CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAA 890
Query: 970 -----DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVD-VNECLTPGVCAHG 1023
D++ H G G CV+S SY C C G++G C D VN C +
Sbjct: 891 LSQGIDVSSLCHNG----GLCVDSGPSYFC-HCPPGFQGSL--CQDHVNPCESRPCQNGA 943
Query: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGC-QDVDECASRASCPTGLCLNTEGSFACSACENGY 1082
C + C C GY D + C +++D C S+ G C G F C AC G+
Sbjct: 944 TCMAQPSGYLCQCAPGY----DGQNCSKELDACQSQPCHNHGTCTPKPGGFHC-ACPPGF 998
Query: 1083 WVNEDGTACE-DLDECAFPGVCPSGV--CTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDE 1138
G CE D+DEC P+G C + A +F C+ P G CE ++D
Sbjct: 999 V----GLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCL-----PGHTGQWCEVEIDP 1049
Query: 1139 CEDPQSSCLGGECKNTVGS---YQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNS 1195
C Q GG C+ T GS + C CP+GF+ G C G HC G CL S
Sbjct: 1050 CHS-QPCFHGGTCEATAGSPLGFICHCPKGFE---GPTCSHRAPSCGFHHCHHGGLCLPS 1105
Query: 1196 HGSFF---CLCAPGFVSAEGGTSCQDVDE---CATTDPCV-GGHCVNTEG----SFNCLC 1244
F C C G+ GG C C PC+ G C T G F C C
Sbjct: 1106 PKPGFPPRCACLSGY----GGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSC 1161
Query: 1245 ETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDC-ID 1303
P P C+ G CE G C GC GDC +
Sbjct: 1162 PHS-SPGPR---------CQKPGAK-----GCEGRSGDGACDAGCSGPGGNWDGGDCSLG 1206
Query: 1304 IDECANDTMCGSHGFC--DNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349
+ + C SH C DG CD E G+DC C
Sbjct: 1207 VPDPWKG--CPSHSRCWLLFRDGQCHPQCDSE-ECLFDGYDCETPPAC 1251
Score = 48.1 bits (113), Expect = 8e-05
Identities = 64/292 (21%), Positives = 91/292 (31%), Gaps = 51/292 (17%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
+D C + G C +L + + C C PG H Q + + C PC G C
Sbjct: 1007 VDECLDQPCHPTGTAACHSLANAFYCQCLPG---HTGQWCEVEIDPCHSQPCFHGGTCEA 1063
Query: 905 RVGS---YSCFCYPGYTLATSGATQECQDINECEQPGVCSGG---------QCTNTEGSY 952
GS + C C G+ T + C G+C C + G
Sbjct: 1064 TAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGP 1123
Query: 953 HC-------ECDQGYIMVRKGHCQDIN-------ECRHPGTCPDGRCVNSPGSYTCL--- 995
C C + G C + C P + P RC PG+ C
Sbjct: 1124 DCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRC-QKPGAKGCEGRS 1182
Query: 996 ---ACEEGYRGQSGSCVDVNECLT------PGVCAHGKCTNLEGSFRCSCEQGYEVTSDE 1046
AC+ G G G+ D +C G +H +C L +C + E
Sbjct: 1183 GDGACDAGCSGPGGNW-DGGDCSLGVPDPWKGCPSHSRCWLLFRDGQC-----HPQCDSE 1236
Query: 1047 KGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNE---DGTACEDLD 1095
+ D +C + +C F CE G E DG C D
Sbjct: 1237 ECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPED 1288
Score = 40.4 bits (93), Expect = 0.016
Identities = 86/335 (25%), Positives = 114/335 (34%), Gaps = 60/335 (17%)
Query: 126 PLG-QQQPAPRTRA--APALPRL-GTPQRSGAAPPTPP-----RGRL----TGRNVCGGQ 172
PLG P+P T + LP G ++ P PP RGR +GR C
Sbjct: 87 PLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCS-- 144
Query: 173 CCPGWTTANSTNHCIKPVCEP-PCQNRGSC--SRPQL-CVCRSGFRGARCEEVIPDEEFD 228
C PGWT ++ C PC N G C + PQ+ C C GF G CE + + D
Sbjct: 145 CMPGWTGEQCQ---LRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQD 201
Query: 229 PQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQ-------SPPAGTLSG 281
P P + +S TL Q P P+ PP G +G
Sbjct: 202 P-------------GPCPKGTSC--HNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNG 246
Query: 282 ----LSQTHPSQQHVGLSRTVRLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPS 337
L S H+ L + P + + G Q DG L P
Sbjct: 247 GTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQ-DGLDTYTCL-CPE 304
Query: 338 SPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRI 397
+ G + +E + + + P C+ G C NS + GG + I
Sbjct: 305 TWTGWDCSEDVDECE-TQGPPHCRN---GGTCQNSAGSFHCVCVSGWGGTSCEENLDDCI 360
Query: 398 YFCQIPCLNGGRCI---GRDECWCPANSTGKFCHL 429
C G CI G C CP TG CHL
Sbjct: 361 ---AATCAPGSTCIDRVGSFSCLCPPGRTGLLCHL 392
Score = 39.7 bits (91), Expect = 0.027
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 4/65 (6%)
Query: 403 PCLNGGRCI----GRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTF 458
PC NGG C+ G+ C C G+ C P P + + G +ALL APL +
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 459 TLPLS 463
PL+
Sbjct: 94 PSPLT 98
Score = 37.4 bits (85), Expect = 0.13
Identities = 37/124 (29%), Positives = 47/124 (37%), Gaps = 23/124 (18%)
Query: 127 LGQQQPAPRTRAAPALPRLGTPQRSGAAPPTPPRGRLTG-RNVCGGQCC-PGWTTAN--S 182
+ QQ P+P L G+ + PP R N C Q C PG T + +
Sbjct: 438 MAQQGPSPCEHGGSCLNTPGS--FNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLA 495
Query: 183 TNHCIKP------VCE--------PPCQNRGSCS---RPQLCVCRSGFRGARCEEVIPDE 225
T HC+ P +CE PC N C C+C GF G RCEE I +
Sbjct: 496 TFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDEC 555
Query: 226 EFDP 229
P
Sbjct: 556 RSSP 559
Score = 37.4 bits (85), Expect = 0.13
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 13/76 (17%)
Query: 148 PQRSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEP-PCQNRGSCSRPQ- 205
P ++GA P G L QC PG+ N + C+ PC N G+C+
Sbjct: 938 PCQNGATCMAQPSGYLC-------QCAPGYDGQNCSKEL--DACQSQPCHNHGTCTPKPG 988
Query: 206 --LCVCRSGFRGARCE 219
C C GF G RCE
Sbjct: 989 GFHCACPPGFVGLRCE 1004
Score = 35.4 bits (80), Expect = 0.51
Identities = 18/41 (43%), Positives = 25/41 (60%), Gaps = 7/41 (17%)
Query: 182 STNHCIKPVCEPPCQNRGSC-SRPQL--CVCRSGFRGARCE 219
ST++C+ PC N G+C +RP C+C GF+G RCE
Sbjct: 767 STDYCVSA----PCFNGGTCVNRPGTFSCLCAMGFQGPRCE 803
Score = 33.1 bits (74), Expect = 2.5
Identities = 119/498 (23%), Positives = 155/498 (31%), Gaps = 148/498 (29%)
Query: 194 PCQNRGSCSRPQL----CVCRSGFRGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRS 249
PC N G+C L C C GF G C+ PD QN++L
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQ--FPDP---CQNAQLCQN------------ 76
Query: 250 SAAGEGTLARAQPPAPQSPPAPQSP--PAGTLSGLSQTHPSQQHVGL---------SRTV 298
G +A PAP P+ SP P+ + L + L S+
Sbjct: 77 -----GGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRG 131
Query: 299 RLHPTATASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPT 358
R H A+ Q S G + RD +P G+ L +
Sbjct: 132 RCHIQASGRPQCSCMPGWTGEQCQLRDFCSA-----NPCVNGGVCLA--------TYPQI 178
Query: 359 ICKQTCARGHCANSCERGDTTTLYSQGGHGHDPKSGFRIYFCQIPCLNGGRC---IGRDE 415
C C G ++CER D + G PC G C +G +
Sbjct: 179 QCH--CPPGFEGHACER-DVNECFQDPG----------------PCPKGTSCHNTLGSFQ 219
Query: 416 CWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSNQLASVNPSLVK 475
C CP G C L + PP S P K STF L L P +
Sbjct: 220 CLCPVGQEGPRCEL---RAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCP------PGFIG 270
Query: 476 VHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWD-SNNIPARSG 534
P+ V HQ GG + ++ P W WD S ++
Sbjct: 271 PDCEVNPDNCVS-HQCQN--GGTCQDGLDTYTCLCPETWTG-------WDCSEDVDECET 320
Query: 535 EPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDCCGSVGAF-------WGVT 587
+ P P R G C N S G+F WG T
Sbjct: 321 QGP-------PHCRN----------GGTCQN-------------SAGSFHCVCVSGWGGT 350
Query: 588 LC---------APCPPRPASPVIEN-GQLEC--PQGYKRLNLTHCQDINECLTLGLCKDA 635
C A C P S I+ G C P G L L H +D+ CL+ DA
Sbjct: 351 SCEENLDDCIAATCAP--GSTCIDRVGSFSCLCPPGRTGL-LCHLEDM--CLSQPCHGDA 405
Query: 636 ECVNT--RGSYLCTCRPG 651
+C GS LC C+PG
Sbjct: 406 QCSTNPLTGSTLCLCQPG 423
Score = 32.3 bits (72), Expect = 4.3
Identities = 124/580 (21%), Positives = 169/580 (29%), Gaps = 167/580 (28%)
Query: 530 PARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCANPLLELTTQEDC-----CGSVGAF- 583
P+ + P R P+G C G C L++L Q+ C C G
Sbjct: 808 PSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQT-LMDLCAQKPCPRNSHCLQTGPSF 866
Query: 584 -------WGVTLC----APCPPRPASPVIE------NGQL----------ECPQGYKRLN 616
W LC + C S I+ NG L CP G++
Sbjct: 867 HCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQG-- 924
Query: 617 LTHCQD-INECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCY 675
+ CQD +N C + A C+ YLC C PG C + Q C+
Sbjct: 925 -SLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY----DGQNCSKELDACQSQP-CH 978
Query: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREICPAGHGYTYASS 735
GTCT P PG F CP G
Sbjct: 979 NH---GTCT----------------------------PKPG--GFHCACPPGFVGLRCEG 1005
Query: 736 DIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVTDTWLEAGTIPDKG----- 790
D+ +E L +P G + +L Q L T W E P
Sbjct: 1006 DV--------DECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFH 1057
Query: 791 ----DSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTDVLVTLSTPGID 846
++ AG + H P G + P + G
Sbjct: 1058 GGTCEATAGSPLGFICHCPKGFEGPTCSHRAP-----------------------SCGFH 1094
Query: 847 RCAAGATNVCGPGTCVNLPDGYRCVCSPGY-----QLHPSQAYCTDDNECLRDPCKGKGR 901
C G +C P P RC C GY P+ C + PC G
Sbjct: 1095 HCHHG--GLCLPSPKPGFPP--RCACLSGYGGPDCLTPPAPKGCGPPS-----PCLYNGS 1145
Query: 902 CINRVG----SYSCFC---YPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYH- 953
C G + C C PG GA + C+ + G C G C+ G++
Sbjct: 1146 CSETTGLGGPGFRCSCPHSSPGPRCQKPGA-KGCEGRS---GDGACDAG-CSGPGGNWDG 1200
Query: 954 CECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNE 1013
+C G KG C + C DG+C S CL +GY +
Sbjct: 1201 GDCSLGVPDPWKG-CPSHSRCWL--LFRDGQCHPQCDSEECLF--DGY-----------D 1244
Query: 1014 CLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVD 1053
C TP C ++ C + EKGC +
Sbjct: 1245 CETPPACT--------PAYDQYCHDHFHNGHCEKGCNTAE 1276
Score = 32.3 bits (72), Expect = 4.3
Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 4/51 (7%)
Query: 173 CCPGWTTANSTNHCIKPVCEPPCQNRGSC-SRPQ--LCVCRSGFRGARCEE 220
C PG+ + +H + P PCQN +C ++P LC C G+ G C +
Sbjct: 918 CPPGFQGSLCQDH-VNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSK 967
Score = 31.6 bits (70), Expect = 7.4
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 10/63 (15%)
Query: 173 CCPGWTTANSTNHCIKPVCE---PPCQNRGSCS-RPQL--CVCRSGFRGARCEEVIPDEE 226
C PG+ S C + + E PC N G C +P C C GF G RC+ + +
Sbjct: 539 CLPGF----SGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECL 594
Query: 227 FDP 229
DP
Sbjct: 595 SDP 597
Score = 31.2 bits (69), Expect = 9.6
Identities = 25/79 (31%), Positives = 30/79 (37%), Gaps = 24/79 (30%)
Query: 165 GRNVCGGQCCPGWT--TANSTNHCIKPVCEPPCQNRGSC-----------SRPQ------ 205
G+ C QC PG+ T + C CQN GSC S P
Sbjct: 47 GQGTC--QCAPGFLGETCQFPDPCQNAQL---CQNGGSCQALLPAPLGLPSSPSPLTPSF 101
Query: 206 LCVCRSGFRGARCEEVIPD 224
LC C GF G RC+ + D
Sbjct: 102 LCTCLPGFTGERCQAKLED 120
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 226 bits (575), Expect = 2e-58
Identities = 161/428 (37%), Positives = 209/428 (48%), Gaps = 54/428 (12%)
Query: 822 IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879
I E++EEQ P + DRC G GP C + D C C GYQL
Sbjct: 164 IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
Query: 880 PSQAYCTDDNECL--RDPCKGKGRCINRVGSYSC----FCYPGYTLATSGATQECQDINE 933
C D NEC+ C+ CIN VGS+ C C GY L + C+DI+E
Sbjct: 209 SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS---CKDIDE 265
Query: 934 CEQ--PGVCSGGQCTNTEGSYHC----ECDQGYIMVRKGHCQDINECRH-PGTCPDGR-C 985
CE C NT GS+ C +C G+I G+C DINEC CP G C
Sbjct: 266 CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTC 325
Query: 986 VNSPGSYTCLA----CEEGYR-GQSGS-CVDVNECLTPG-VCAHG-KCTNLEGSFRCSCE 1037
+N+ GSYTC C GY + G+ CVDV+EC P C G +C N GSFRC C+
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 1038 QGYEVTSDEKGCQDVDECASRASCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096
GY + C DV+EC G C NT GS+ CS C G+ ++ DG +CED++E
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS-CSVGFRLSVDGRSCEDINE 444
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL-GDSCEDVDECEDPQSSCL-GGECKNT 1154
C+ C S C N GS+ C C GY+ S + G +CED+DEC P + C N
Sbjct: 445 CS-SSPC-SQECANVYGSYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 1155 VGSYQCLCP-QGFQLA-NGTVCEDVNECM-GEEHCAPHGECLNSHGSFFCLC--APGFVS 1209
GS+QC CP G++LA NG C+D++EC+ G +C+ + C N G F CL P
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Query: 1210 AEGGTSCQ 1217
T C+
Sbjct: 562 RSAATRCE 569
Score = 222 bits (566), Expect = 2e-57
Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069
+ C G C +C + CSC GY++ SD C+DV+EC + + SC G C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121
GSF C S+C GY + ED +C+D+DEC P +C NT GSF C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174
G+ LG +C D++EC + C +G C NT GSY C C +G+ L GT C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232
DV+EC E C C+NS GSF C C G+ C DV+EC + GH
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
Query: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
C NT GS+ C C GF+ S + C DI+EC P + +C N GSY+C C+ G
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
Query: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346
+ ++ C DIDECA T G H C N GSF+C C G+ ++P+G +C D+
Sbjct: 469 YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
Query: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379
+EC + C C N++G F CL E Y
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
Score = 216 bits (549), Expect = 2e-55
Identities = 157/445 (35%), Positives = 216/445 (48%), Gaps = 51/445 (11%)
Query: 1041 EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP 1100
EV +++ D C C C +T CS C GY + DG +CED++EC
Sbjct: 166 EVEEEQEDPYLNDRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITG 223
Query: 1101 G-VCPSGV-CTNTAGSFSCK---DCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNT 1154
C G C NT GSF C+ C GY + +SC+D+DECE +CL C+NT
Sbjct: 224 SHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNT 282
Query: 1155 VGSYQCL----CPQGF-QLANGTVCEDVNECMGEEHCAPHGE-CLNSHGSFFCL-----C 1203
+GS++C C GF Q A G C D+NEC+ P G C+N+ GS+ C C
Sbjct: 283 LGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
Query: 1204 APGFVSAEGGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDID 1261
G+ E GT C DVDECA +PC GH CVN+ GSF C C+TG+ S CVD++
Sbjct: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
Query: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCD 1320
EC+ Y +CG KCEN+ GSY C C GF ++ +G C DI+EC++ + C C
Sbjct: 402 ECQRYPGRLCG-HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS-SPCSQE--CA 455
Query: 1321 NTDGSFRCLCDQGFEISP-SGWDCVDVNECELMLA--VCGAALCENVEGSFLCLCASDLE 1377
N GS++C C +G+++S G C D++EC L +C + C N+ GSF C C S
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPS--- 511
Query: 1378 EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECC 1437
P G Q + E TG H C++ Q G EC
Sbjct: 512 ----SGYRLAPNGRNCQDIDECVTGIH-NCSINETCFNIQGGF---------RCLAFECP 557
Query: 1438 CTQGASWGDACDLCPSEDSAEFSEI 1462
S C+ P ++ E S++
Sbjct: 558 ENYRRSAATRCERLPCHENRECSKL 582
Score = 186 bits (473), Expect = 1e-46
Identities = 149/474 (31%), Positives = 202/474 (42%), Gaps = 98/474 (20%)
Query: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153
D C G C C +T C C GY+ G SCEDV+EC SC LG C N
Sbjct: 178 DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
Query: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204
TVGS++C C G++L C+D++EC G +C P C N+ GSF C C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257
GF+ G +C D++EC + PC GH C+NTEGS+ C C G+ + E C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314
VD+DEC +P +C NSPGS+RC C+ G++ + C+D++EC +CG
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
Query: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
C+NT GS+ C C GF +S G C D+NEC + C C NV GS+ C C
Sbjct: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
Query: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
+ D C + + E PTG H + ++ G CS
Sbjct: 468 GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
Query: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
CPS + P+G+ D DECV
Sbjct: 509 ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
Query: 1493 GPGLCPNGRCLNTVPGYVCL---CNPGFHYDASHKKCEDHDECQDLAC-ENGEC 1542
N C N G+ CL C + A+ + C+ L C EN EC
Sbjct: 533 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATR-------CERLPCHENREC 579
Score = 115 bits (288), Expect = 4e-25
Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)
Query: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278
D C PC C +T C C G+Q + C D++EC G C + C N
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
Query: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331
+ GS+RC C G+ + + C DIDEC + C C NT GSFRC C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
GF I + +C+D+NEC + A C C N EGS+ C ++ + H G
Sbjct: 296 SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
+ E AP C G + C + G C C G + +
Sbjct: 352 TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510
C D +EC + LC + +C NT+ Y+
Sbjct: 397 C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
Query: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569
C C+ GF + CED +EC C EC N GS+ C+C L D+ C +
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
Query: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613
H IC + N CS P G+R CQD
Sbjct: 483 DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793
AE CG + RCV + C+C G+ D CVDVNEC P LC H C
Sbjct: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
Query: 1794 ENTEGSYRCHCSPGY 1808
ENT GSY C CS G+
Sbjct: 416 ENTLGSYLCSCSVGF 430
Score = 50.4 bits (119), Expect = 2e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801
C+ YTC +C G+ L+ CVDV+EC PA C G+ C N+ GS+R
Sbjct: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
Query: 1802 CHCSPGY 1808
C C GY
Sbjct: 382 CECKTGY 388
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
F+G+ + C +N C+ +C Y C C GF+L +C D+NEC
Sbjct: 390 FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
Query: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
+ P C N GSY+C+C GY
Sbjct: 447 SSPC----SQECANVYGSYQCYCRRGY 469
Score = 45.4 bits (106), Expect = 5e-04
Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)
Query: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635
+++ APCP S + C +GY LN T C D++EC K
Sbjct: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690
CVN+ GS+ C C+ G D CV G C +LG C+ + R
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 691 ITKQICCCSRVGKAWGSECEK 711
++ C + + S C +
Sbjct: 432 LSVDGRSCEDINECSSSPCSQ 452
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803
+C + C CF G+QL + ++C DVNEC + G + C NT GS+RC
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
Query: 1804 -CSPGY 1808
C GY
Sbjct: 247 SCGTGY 252
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)
Query: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775
G+E + C ++ CE+G C + C C GF DA C+D+
Sbjct: 251 GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
Query: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808
NEC ++ P C G+ C NTEGSY C +C GY
Sbjct: 310 NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)
Query: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657
+L+C G+ + L +C DINECL++ C C+NT GSY C C G L+
Sbjct: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
Query: 658 RSRCV 662
+RCV
Sbjct: 351 GTRCV 355
Score = 42.4 bits (98), Expect = 0.004
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786
+ C +N C + C V Y C C G+QL D + C D++EC G +
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
Query: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808
C N GS++C C S GY
Sbjct: 494 CSYR--CINIPGSFQCSCPSSGY 514
Score = 37.0 bits (84), Expect = 0.18
Identities = 36/138 (26%), Positives = 57/138 (41%), Gaps = 14/138 (10%)
Query: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645
+PC A+ V + Q C +GY+ ++ C+DI+EC T G C+N GS+
Sbjct: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
Query: 646 CTC-RPGLMLDPSRSRCVS-DKAIS-----MLQGLCYRSLGPGTCTLPLAQRITKQICC- 697
C+C G L P+ C D+ ++ + C+ G C ++
Sbjct: 507 CSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAAT 566
Query: 698 -CSRVGKAWGSECEKCPL 714
C R+ EC K PL
Sbjct: 567 RCERLPCHENRECSKLPL 584
Score = 36.6 bits (83), Expect = 0.23
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654
C+DINEC + + EC N GSY C CR G L
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)
Query: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659
C GY+ L+ C+D+NEC+T C+ E C+NT GS+ C +C G L S
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683
C S + +C +LG C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 225 bits (574), Expect = 3e-58
Identities = 158/411 (38%), Positives = 205/411 (49%), Gaps = 52/411 (12%)
Query: 822 IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879
I E++EEQ P + DRC G GP C + D C C GYQL
Sbjct: 164 IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
Query: 880 PSQAYCTDDNECL--RDPCKGKGRCINRVGSYSC----FCYPGYTLATSGATQECQDINE 933
C D NEC+ C+ CIN VGS+ C C GY L + C+DI+E
Sbjct: 209 SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS---CKDIDE 265
Query: 934 CEQ--PGVCSGGQCTNTEGSYHC----ECDQGYIMVRKGHCQDINECRH-PGTCPDGR-C 985
CE C NT GS+ C +C G+I G+C DINEC CP G C
Sbjct: 266 CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTC 325
Query: 986 VNSPGSYTCLA----CEEGYR-GQSGS-CVDVNECLTPG-VCAHG-KCTNLEGSFRCSCE 1037
+N+ GSYTC C GY + G+ CVDV+EC P C G +C N GSFRC C+
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 1038 QGYEVTSDEKGCQDVDECASRASCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096
GY + C DV+EC G C NT GS+ CS C G+ ++ DG +CED++E
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS-CSVGFRLSVDGRSCEDINE 444
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL-GDSCEDVDECEDPQSSCL-GGECKNT 1154
C+ C S C N GS+ C C GY+ S + G +CED+DEC P + C N
Sbjct: 445 CS-SSPC-SQECANVYGSYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 1155 VGSYQCLCP-QGFQLA-NGTVCEDVNECM-GEEHCAPHGECLNSHGSFFCL 1202
GS+QC CP G++LA NG C+D++EC+ G +C+ + C N G F CL
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 222 bits (566), Expect = 2e-57
Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069
+ C G C +C + CSC GY++ SD C+DV+EC + + SC G C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121
GSF C S+C GY + ED +C+D+DEC P +C NT GSF C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174
G+ LG +C D++EC + C +G C NT GSY C C +G+ L GT C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232
DV+EC E C C+NS GSF C C G+ C DV+EC + GH
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
Query: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
C NT GS+ C C GF+ S + C DI+EC P + +C N GSY+C C+ G
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
Query: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346
+ ++ C DIDECA T G H C N GSF+C C G+ ++P+G +C D+
Sbjct: 469 YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
Query: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379
+EC + C C N++G F CL E Y
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
Score = 215 bits (548), Expect = 3e-55
Identities = 147/387 (37%), Positives = 199/387 (51%), Gaps = 41/387 (10%)
Query: 1041 EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP 1100
EV +++ D C C C +T CS C GY + DG +CED++EC
Sbjct: 166 EVEEEQEDPYLNDRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITG 223
Query: 1101 G-VCPSGV-CTNTAGSFSCK---DCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNT 1154
C G C NT GSF C+ C GY + +SC+D+DECE +CL C+NT
Sbjct: 224 SHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNT 282
Query: 1155 VGSYQCL----CPQGF-QLANGTVCEDVNECMGEEHCAPHGE-CLNSHGSFFCL-----C 1203
+GS++C C GF Q A G C D+NEC+ P G C+N+ GS+ C C
Sbjct: 283 LGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
Query: 1204 APGFVSAEGGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDID 1261
G+ E GT C DVDECA +PC GH CVN+ GSF C C+TG+ S CVD++
Sbjct: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
Query: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCD 1320
EC+ Y +CG KCEN+ GSY C C GF ++ +G C DI+EC++ + C C
Sbjct: 402 ECQRYPGRLCG-HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS-SPCSQE--CA 455
Query: 1321 NTDGSFRCLCDQGFEISP-SGWDCVDVNECELMLA--VCGAALCENVEGSFLCLCASDLE 1377
N GS++C C +G+++S G C D++EC L +C + C N+ GSF C C S
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPS--- 511
Query: 1378 EYDAQEGHCRPRGAGGQSMSEAPTGDH 1404
P G Q + E TG H
Sbjct: 512 ----SGYRLAPNGRNCQDIDECVTGIH 534
Score = 182 bits (463), Expect = 2e-45
Identities = 143/456 (31%), Positives = 195/456 (42%), Gaps = 90/456 (19%)
Query: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153
D C G C C +T C C GY+ G SCEDV+EC SC LG C N
Sbjct: 178 DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
Query: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204
TVGS++C C G++L C+D++EC G +C P C N+ GSF C C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257
GF+ G +C D++EC + PC GH C+NTEGS+ C C G+ + E C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314
VD+DEC +P +C NSPGS+RC C+ G++ + C+D++EC +CG
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
Query: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
C+NT GS+ C C GF +S G C D+NEC + C C NV GS+ C C
Sbjct: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
Query: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
+ D C + + E PTG H + ++ G CS
Sbjct: 468 GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
Query: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
CPS + P+G+ D DECV
Sbjct: 509 ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
Query: 1493 GPGLCPNGRCLNTVPGYVCL---CNPGFHYDASHKK 1525
N C N G+ CL C + A+ +K
Sbjct: 533 IHNCSINETCFNIQGGFRCLAFECPENYRRSAATQK 568
Score = 115 bits (288), Expect = 4e-25
Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)
Query: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278
D C PC C +T C C G+Q + C D++EC G C + C N
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
Query: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331
+ GS+RC C G+ + + C DIDEC + C C NT GSFRC C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
GF I + +C+D+NEC + A C C N EGS+ C ++ + H G
Sbjct: 296 SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
+ E AP C G + C + G C C G + +
Sbjct: 352 TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510
C D +EC + LC + +C NT+ Y+
Sbjct: 397 C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
Query: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569
C C+ GF + CED +EC C EC N GS+ C+C L D+ C +
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
Query: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613
H IC + N CS P G+R CQD
Sbjct: 483 DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793
AE CG + RCV + C+C G+ D CVDVNEC P LC H C
Sbjct: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
Query: 1794 ENTEGSYRCHCSPGY 1808
ENT GSY C CS G+
Sbjct: 416 ENTLGSYLCSCSVGF 430
Score = 50.4 bits (119), Expect = 2e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801
C+ YTC +C G+ L+ CVDV+EC PA C G+ C N+ GS+R
Sbjct: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
Query: 1802 CHCSPGY 1808
C C GY
Sbjct: 382 CECKTGY 388
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
F+G+ + C +N C+ +C Y C C GF+L +C D+NEC
Sbjct: 390 FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
Query: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
+ P C N GSY+C+C GY
Sbjct: 447 SSPC----SQECANVYGSYQCYCRRGY 469
Score = 45.4 bits (106), Expect = 5e-04
Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)
Query: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635
+++ APCP S + C +GY LN T C D++EC K
Sbjct: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690
CVN+ GS+ C C+ G D CV G C +LG C+ + R
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 691 ITKQICCCSRVGKAWGSECEK 711
++ C + + S C +
Sbjct: 432 LSVDGRSCEDINECSSSPCSQ 452
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803
+C + C CF G+QL + ++C DVNEC + G + C NT GS+RC
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
Query: 1804 -CSPGY 1808
C GY
Sbjct: 247 SCGTGY 252
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)
Query: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775
G+E + C ++ CE+G C + C C GF DA C+D+
Sbjct: 251 GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
Query: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808
NEC ++ P C G+ C NTEGSY C +C GY
Sbjct: 310 NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)
Query: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657
+L+C G+ + L +C DINECL++ C C+NT GSY C C G L+
Sbjct: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
Query: 658 RSRCV 662
+RCV
Sbjct: 351 GTRCV 355
Score = 42.4 bits (98), Expect = 0.004
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786
+ C +N C + C V Y C C G+QL D + C D++EC G +
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
Query: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808
C N GS++C C S GY
Sbjct: 494 CSYR--CINIPGSFQCSCPSSGY 514
Score = 36.6 bits (83), Expect = 0.23
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654
C+DINEC + + EC N GSY C CR G L
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
Score = 36.2 bits (82), Expect = 0.30
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 6/77 (7%)
Query: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645
+PC A+ V + Q C +GY+ ++ C+DI+EC T G C+N GS+
Sbjct: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
Query: 646 CTC-RPGLMLDPSRSRC 661
C+C G L P+ C
Sbjct: 507 CSCPSSGYRLAPNGRNC 523
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)
Query: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659
C GY+ L+ C+D+NEC+T C+ E C+NT GS+ C +C G L S
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683
C S + +C +LG C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
Score = 31.6 bits (70), Expect = 7.4
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 605 QLECPQGYKRL--NLTHCQDINECLT-LGLCKDAE-CVNTRGSYLC 646
Q CP RL N +CQDI+EC+T + C E C N +G + C
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 225 bits (574), Expect = 3e-58
Identities = 158/411 (38%), Positives = 205/411 (49%), Gaps = 52/411 (12%)
Query: 822 IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879
I E++EEQ P + DRC G GP C + D C C GYQL
Sbjct: 164 IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
Query: 880 PSQAYCTDDNECL--RDPCKGKGRCINRVGSYSC----FCYPGYTLATSGATQECQDINE 933
C D NEC+ C+ CIN VGS+ C C GY L + C+DI+E
Sbjct: 209 SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS---CKDIDE 265
Query: 934 CEQ--PGVCSGGQCTNTEGSYHC----ECDQGYIMVRKGHCQDINECRH-PGTCPDGR-C 985
CE C NT GS+ C +C G+I G+C DINEC CP G C
Sbjct: 266 CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTC 325
Query: 986 VNSPGSYTCLA----CEEGYR-GQSGS-CVDVNECLTPG-VCAHG-KCTNLEGSFRCSCE 1037
+N+ GSYTC C GY + G+ CVDV+EC P C G +C N GSFRC C+
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 1038 QGYEVTSDEKGCQDVDECASRASCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096
GY + C DV+EC G C NT GS+ CS C G+ ++ DG +CED++E
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS-CSVGFRLSVDGRSCEDINE 444
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL-GDSCEDVDECEDPQSSCL-GGECKNT 1154
C+ C S C N GS+ C C GY+ S + G +CED+DEC P + C N
Sbjct: 445 CS-SSPC-SQECANVYGSYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 1155 VGSYQCLCP-QGFQLA-NGTVCEDVNECM-GEEHCAPHGECLNSHGSFFCL 1202
GS+QC CP G++LA NG C+D++EC+ G +C+ + C N G F CL
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 222 bits (566), Expect = 2e-57
Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069
+ C G C +C + CSC GY++ SD C+DV+EC + + SC G C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121
GSF C S+C GY + ED +C+D+DEC P +C NT GSF C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174
G+ LG +C D++EC + C +G C NT GSY C C +G+ L GT C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232
DV+EC E C C+NS GSF C C G+ C DV+EC + GH
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
Query: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
C NT GS+ C C GF+ S + C DI+EC P + +C N GSY+C C+ G
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
Query: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346
+ ++ C DIDECA T G H C N GSF+C C G+ ++P+G +C D+
Sbjct: 469 YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
Query: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379
+EC + C C N++G F CL E Y
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
Score = 215 bits (548), Expect = 3e-55
Identities = 147/387 (37%), Positives = 199/387 (51%), Gaps = 41/387 (10%)
Query: 1041 EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP 1100
EV +++ D C C C +T CS C GY + DG +CED++EC
Sbjct: 166 EVEEEQEDPYLNDRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITG 223
Query: 1101 G-VCPSGV-CTNTAGSFSCK---DCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNT 1154
C G C NT GSF C+ C GY + +SC+D+DECE +CL C+NT
Sbjct: 224 SHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNT 282
Query: 1155 VGSYQCL----CPQGF-QLANGTVCEDVNECMGEEHCAPHGE-CLNSHGSFFCL-----C 1203
+GS++C C GF Q A G C D+NEC+ P G C+N+ GS+ C C
Sbjct: 283 LGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
Query: 1204 APGFVSAEGGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDID 1261
G+ E GT C DVDECA +PC GH CVN+ GSF C C+TG+ S CVD++
Sbjct: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
Query: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCD 1320
EC+ Y +CG KCEN+ GSY C C GF ++ +G C DI+EC++ + C C
Sbjct: 402 ECQRYPGRLCG-HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS-SPCSQE--CA 455
Query: 1321 NTDGSFRCLCDQGFEISP-SGWDCVDVNECELMLA--VCGAALCENVEGSFLCLCASDLE 1377
N GS++C C +G+++S G C D++EC L +C + C N+ GSF C C S
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPS--- 511
Query: 1378 EYDAQEGHCRPRGAGGQSMSEAPTGDH 1404
P G Q + E TG H
Sbjct: 512 ----SGYRLAPNGRNCQDIDECVTGIH 534
Score = 182 bits (461), Expect = 3e-45
Identities = 140/440 (31%), Positives = 189/440 (42%), Gaps = 87/440 (19%)
Query: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153
D C G C C +T C C GY+ G SCEDV+EC SC LG C N
Sbjct: 178 DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
Query: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204
TVGS++C C G++L C+D++EC G +C P C N+ GSF C C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257
GF+ G +C D++EC + PC GH C+NTEGS+ C C G+ + E C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314
VD+DEC +P +C NSPGS+RC C+ G++ + C+D++EC +CG
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
Query: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
C+NT GS+ C C GF +S G C D+NEC + C C NV GS+ C C
Sbjct: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
Query: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
+ D C + + E PTG H + ++ G CS
Sbjct: 468 GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
Query: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
CPS + P+G+ D DECV
Sbjct: 509 ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
Query: 1493 GPGLCPNGRCLNTVPGYVCL 1512
N C N G+ CL
Sbjct: 533 IHNCSINETCFNIQGGFRCL 552
Score = 115 bits (288), Expect = 4e-25
Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)
Query: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278
D C PC C +T C C G+Q + C D++EC G C + C N
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
Query: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331
+ GS+RC C G+ + + C DIDEC + C C NT GSFRC C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
GF I + +C+D+NEC + A C C N EGS+ C ++ + H G
Sbjct: 296 SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
+ E AP C G + C + G C C G + +
Sbjct: 352 TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510
C D +EC + LC + +C NT+ Y+
Sbjct: 397 C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
Query: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569
C C+ GF + CED +EC C EC N GS+ C+C L D+ C +
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
Query: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613
H IC + N CS P G+R CQD
Sbjct: 483 DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793
AE CG + RCV + C+C G+ D CVDVNEC P LC H C
Sbjct: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
Query: 1794 ENTEGSYRCHCSPGY 1808
ENT GSY C CS G+
Sbjct: 416 ENTLGSYLCSCSVGF 430
Score = 50.4 bits (119), Expect = 2e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801
C+ YTC +C G+ L+ CVDV+EC PA C G+ C N+ GS+R
Sbjct: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
Query: 1802 CHCSPGY 1808
C C GY
Sbjct: 382 CECKTGY 388
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
F+G+ + C +N C+ +C Y C C GF+L +C D+NEC
Sbjct: 390 FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
Query: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
+ P C N GSY+C+C GY
Sbjct: 447 SSPC----SQECANVYGSYQCYCRRGY 469
Score = 45.4 bits (106), Expect = 5e-04
Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)
Query: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635
+++ APCP S + C +GY LN T C D++EC K
Sbjct: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690
CVN+ GS+ C C+ G D CV G C +LG C+ + R
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 691 ITKQICCCSRVGKAWGSECEK 711
++ C + + S C +
Sbjct: 432 LSVDGRSCEDINECSSSPCSQ 452
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803
+C + C CF G+QL + ++C DVNEC + G + C NT GS+RC
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
Query: 1804 -CSPGY 1808
C GY
Sbjct: 247 SCGTGY 252
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)
Query: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775
G+E + C ++ CE+G C + C C GF DA C+D+
Sbjct: 251 GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
Query: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808
NEC ++ P C G+ C NTEGSY C +C GY
Sbjct: 310 NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)
Query: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657
+L+C G+ + L +C DINECL++ C C+NT GSY C C G L+
Sbjct: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
Query: 658 RSRCV 662
+RCV
Sbjct: 351 GTRCV 355
Score = 42.4 bits (98), Expect = 0.004
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786
+ C +N C + C V Y C C G+QL D + C D++EC G +
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
Query: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808
C N GS++C C S GY
Sbjct: 494 CSYR--CINIPGSFQCSCPSSGY 514
Score = 36.6 bits (83), Expect = 0.23
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654
C+DINEC + + EC N GSY C CR G L
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
Score = 36.2 bits (82), Expect = 0.30
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 6/77 (7%)
Query: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645
+PC A+ V + Q C +GY+ ++ C+DI+EC T G C+N GS+
Sbjct: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
Query: 646 CTC-RPGLMLDPSRSRC 661
C+C G L P+ C
Sbjct: 507 CSCPSSGYRLAPNGRNC 523
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)
Query: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659
C GY+ L+ C+D+NEC+T C+ E C+NT GS+ C +C G L S
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683
C S + +C +LG C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
Score = 31.6 bits (70), Expect = 7.4
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 605 QLECPQGYKRL--NLTHCQDINECLT-LGLCKDAE-CVNTRGSYLC 646
Q CP RL N +CQDI+EC+T + C E C N +G + C
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 225 bits (574), Expect = 3e-58
Identities = 158/411 (38%), Positives = 205/411 (49%), Gaps = 52/411 (12%)
Query: 822 IAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGP--GTCVNLPDGYRCVCSPGYQLH 879
I E++EEQ P + DRC G GP C + D C C GYQL
Sbjct: 164 IIEVEEEQEDPYLN----------DRCRGG-----GPCKQQCRDTGDEVVCSCFVGYQLL 208
Query: 880 PSQAYCTDDNECL--RDPCKGKGRCINRVGSYSC----FCYPGYTLATSGATQECQDINE 933
C D NEC+ C+ CIN VGS+ C C GY L + C+DI+E
Sbjct: 209 SDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNS---CKDIDE 265
Query: 934 CEQ--PGVCSGGQCTNTEGSYHC----ECDQGYIMVRKGHCQDINECRH-PGTCPDGR-C 985
CE C NT GS+ C +C G+I G+C DINEC CP G C
Sbjct: 266 CESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTC 325
Query: 986 VNSPGSYTCLA----CEEGYR-GQSGS-CVDVNECLTPG-VCAHG-KCTNLEGSFRCSCE 1037
+N+ GSYTC C GY + G+ CVDV+EC P C G +C N GSFRC C+
Sbjct: 326 INTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECK 385
Query: 1038 QGYEVTSDEKGCQDVDECASRASCPTG-LCLNTEGSFACSACENGYWVNEDGTACEDLDE 1096
GY + C DV+EC G C NT GS+ CS C G+ ++ DG +CED++E
Sbjct: 386 TGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCS-CSVGFRLSVDGRSCEDINE 444
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPL-GDSCEDVDECEDPQSSCL-GGECKNT 1154
C+ C S C N GS+ C C GY+ S + G +CED+DEC P + C N
Sbjct: 445 CS-SSPC-SQECANVYGSYQCY-CRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINI 501
Query: 1155 VGSYQCLCP-QGFQLA-NGTVCEDVNECM-GEEHCAPHGECLNSHGSFFCL 1202
GS+QC CP G++LA NG C+D++EC+ G +C+ + C N G F CL
Sbjct: 502 PGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCL 552
Score = 222 bits (566), Expect = 2e-57
Identities = 147/394 (37%), Positives = 199/394 (50%), Gaps = 37/394 (9%)
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRA-SCPTG-LCLNT 1069
+ C G C +C + CSC GY++ SD C+DV+EC + + SC G C+NT
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINT 236
Query: 1070 EGSFAC---SACENGYWVNEDGTACEDLDEC--AFPGVCPSGVCTNTAGSFSCK---DCD 1121
GSF C S+C GY + ED +C+D+DEC P +C NT GSF C+ C
Sbjct: 237 VGSFRCQRDSSCGTGYELTED-NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1122 GGYRPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCL-----CPQGFQL-ANGTVC 1174
G+ LG +C D++EC + C +G C NT GSY C C +G+ L GT C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1175 EDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH- 1232
DV+EC E C C+NS GSF C C G+ C DV+EC + GH
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHK 414
Query: 1233 CVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPG 1292
C NT GS+ C C GF+ S + C DI+EC P + +C N GSY+C C+ G
Sbjct: 415 CENTLGSYLCSCSVGFRLSVDGRSCEDINECS--SSPC--SQECANVYGSYQCY--CRRG 468
Query: 1293 FHMA--PNGDCIDIDECANDTMCGSH---GFCDNTDGSFRCLC-DQGFEISPSGWDCVDV 1346
+ ++ C DIDECA T G H C N GSF+C C G+ ++P+G +C D+
Sbjct: 469 YQLSDVDGVTCEDIDECALPT--GGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDI 526
Query: 1347 NECELMLAVCGA-ALCENVEGSFLCLCASDLEEY 1379
+EC + C C N++G F CL E Y
Sbjct: 527 DECVTGIHNCSINETCFNIQGGFRCLAFECPENY 560
Score = 215 bits (548), Expect = 3e-55
Identities = 147/387 (37%), Positives = 199/387 (51%), Gaps = 41/387 (10%)
Query: 1041 EVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP 1100
EV +++ D C C C +T CS C GY + DG +CED++EC
Sbjct: 166 EVEEEQEDPYLNDRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITG 223
Query: 1101 G-VCPSGV-CTNTAGSFSCK---DCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNT 1154
C G C NT GSF C+ C GY + +SC+D+DECE +CL C+NT
Sbjct: 224 SHSCRLGESCINTVGSFRCQRDSSCGTGYELTE-DNSCKDIDECESGIHNCLPDFICQNT 282
Query: 1155 VGSYQCL----CPQGF-QLANGTVCEDVNECMGEEHCAPHGE-CLNSHGSFFCL-----C 1203
+GS++C C GF Q A G C D+NEC+ P G C+N+ GS+ C C
Sbjct: 283 LGSFRCRPKLQCKSGFIQDALGN-CIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNC 341
Query: 1204 APGFVSAEGGTSCQDVDECAT-TDPCVGGH-CVNTEGSFNCLCETGFQPSPESGECVDID 1261
G+ E GT C DVDECA +PC GH CVN+ GSF C C+TG+ S CVD++
Sbjct: 342 GRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVN 401
Query: 1262 ECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCD 1320
EC+ Y +CG KCEN+ GSY C C GF ++ +G C DI+EC++ + C C
Sbjct: 402 ECQRYPGRLCG-HKCENTLGSYLC--SCSVGFRLSVDGRSCEDINECSS-SPCSQE--CA 455
Query: 1321 NTDGSFRCLCDQGFEISP-SGWDCVDVNECELMLA--VCGAALCENVEGSFLCLCASDLE 1377
N GS++C C +G+++S G C D++EC L +C + C N+ GSF C C S
Sbjct: 456 NVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHIC-SYRCINIPGSFQCSCPS--- 511
Query: 1378 EYDAQEGHCRPRGAGGQSMSEAPTGDH 1404
P G Q + E TG H
Sbjct: 512 ----SGYRLAPNGRNCQDIDECVTGIH 534
Score = 182 bits (461), Expect = 3e-45
Identities = 140/440 (31%), Positives = 189/440 (42%), Gaps = 87/440 (19%)
Query: 1095 DECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGECKN 1153
D C G C C +T C C GY+ G SCEDV+EC SC LG C N
Sbjct: 178 DRCRGGGPCKQQ-CRDTGDEVVCS-CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCIN 235
Query: 1154 TVGSYQCL----CPQGFQLANGTVCEDVNEC-MGEEHCAPHGECLNSHGSFFCL----CA 1204
TVGS++C C G++L C+D++EC G +C P C N+ GSF C C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1205 PGFVSAEGGTSCQDVDECATTD-PCVGGH-CVNTEGSFNCL-----CETGFQPSPESGEC 1257
GF+ G +C D++EC + PC GH C+NTEGS+ C C G+ + E C
Sbjct: 296 SGFIQDALG-NCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRC 354
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHM-APNGDCIDIDECAN--DTMCG 1314
VD+DEC +P +C NSPGS+RC C+ G++ + C+D++EC +CG
Sbjct: 355 VDVDECAPPAEPCGKGHRCVNSPGSFRCE--CKTGYYFDGISRMCVDVNECQRYPGRLCG 412
Query: 1315 SHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCAS 1374
C+NT GS+ C C GF +S G C D+NEC + C C NV GS+ C C
Sbjct: 413 HK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSS--SPCSQE-CANVYGSYQCYCRR 467
Query: 1375 DLEEYDAQEGHCRPRGAGGQSMSEA--PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTT 1432
+ D C + + E PTG H + ++ G CS
Sbjct: 468 GYQLSDVDGVTC-------EDIDECALPTGGHICSYRCINI----PGSFQCS-------- 508
Query: 1433 QAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
CPS + P+G+ D DECV
Sbjct: 509 ------------------CPSSGY----RLAPNGRNC--------------QDIDECVTG 532
Query: 1493 GPGLCPNGRCLNTVPGYVCL 1512
N C N G+ CL
Sbjct: 533 IHNCSINETCFNIQGGFRCL 552
Score = 115 bits (288), Expect = 4e-25
Identities = 110/408 (26%), Positives = 151/408 (37%), Gaps = 74/408 (18%)
Query: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CEN 1278
D C PC C +T C C G+Q + C D++EC G C + C N
Sbjct: 178 DRCRGGGPCKQ-QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECIT-GSHSCRLGESCIN 235
Query: 1279 SPGSYRCVL--GCQPGFHMAPNGDCIDIDECANDTM-CGSHGFCDNTDGSFRCL----CD 1331
+ GS+RC C G+ + + C DIDEC + C C NT GSFRC C
Sbjct: 236 TVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCK 295
Query: 1332 QGFEISPSGWDCVDVNECELMLAVCGAA-LCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
GF I + +C+D+NEC + A C C N EGS+ C ++ + H G
Sbjct: 296 SGF-IQDALGNCIDINECLSISAPCPIGHTCINTEGSYT--CQKNVPNC-GRGYHLNEEG 351
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
+ E AP C G + C + G C C G + +
Sbjct: 352 TRCVDVDEC-------APPAEPCGKGHR----CVNSPG----SFRCECKTGYYFDGISRM 396
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYV 1510
C D +EC + LC + +C NT+ Y+
Sbjct: 397 C--------------------------------VDVNECQRYPGRLCGH-KCENTLGSYL 423
Query: 1511 CLCNPGFHYDASHKKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTL-DLSQQRCMNS 1569
C C+ GF + CED +EC C EC N GS+ C+C L D+ C +
Sbjct: 424 CSCSVGFRLSVDGRSCEDINECSSSPCSQ-ECANVYGSYQCYCRRGYQLSDVDGVTCEDI 482
Query: 1570 TSSTEDLPDHDIHMDICWKKVTN----DVCSEPLRGHRTTYTECCCQD 1613
H IC + N CS P G+R CQD
Sbjct: 483 DECALPTGGH-----ICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQD 525
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/75 (44%), Positives = 38/75 (50%), Gaps = 8/75 (10%)
Query: 1734 AEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYC 1793
AE CG + RCV + C+C G+ D CVDVNEC P LC H C
Sbjct: 364 AEPCG-----KGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQ--RYPGRLCGH-KC 415
Query: 1794 ENTEGSYRCHCSPGY 1808
ENT GSY C CS G+
Sbjct: 416 ENTLGSYLCSCSVGF 430
Score = 50.4 bits (119), Expect = 2e-05
Identities = 26/67 (38%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 1748 CVRVREGYTC-----DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYR 1801
C+ YTC +C G+ L+ CVDV+EC PA C G+ C N+ GS+R
Sbjct: 325 CINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAP---PAEPCGKGHRCVNSPGSFR 381
Query: 1802 CHCSPGY 1808
C C GY
Sbjct: 382 CECKTGY 388
Score = 47.4 bits (111), Expect = 1e-04
Identities = 27/87 (31%), Positives = 39/87 (44%), Gaps = 14/87 (16%)
Query: 1729 FEGLQAEECGILNGCEN-------GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
F+G+ + C +N C+ +C Y C C GF+L +C D+NEC
Sbjct: 390 FDGI-SRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECS-- 446
Query: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
+ P C N GSY+C+C GY
Sbjct: 447 SSPC----SQECANVYGSYQCYCRRGY 469
Score = 45.4 bits (106), Expect = 5e-04
Identities = 36/141 (25%), Positives = 54/141 (38%), Gaps = 16/141 (11%)
Query: 586 VTLCAPCP------PRPASPVIENGQLECPQGYKRLNL--THCQDINECLTLG--LCKDA 635
+++ APCP S + C +GY LN T C D++EC K
Sbjct: 313 LSISAPCPIGHTCINTEGSYTCQKNVPNCGRGY-HLNEEGTRCVDVDECAPPAEPCGKGH 371
Query: 636 ECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQG-----LCYRSLGPGTCTLPLAQR 690
CVN+ GS+ C C+ G D CV G C +LG C+ + R
Sbjct: 372 RCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFR 431
Query: 691 ITKQICCCSRVGKAWGSECEK 711
++ C + + S C +
Sbjct: 432 LSVDGRSCEDINECSSSPCSQ 452
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 1747 RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCH--- 1803
+C + C CF G+QL + ++C DVNEC + G + C NT GS+RC
Sbjct: 189 QCRDTGDEVVCSCFVGYQLLSDGVSCEDVNEC--ITGSHSCRLGESCINTVGSFRCQRDS 246
Query: 1804 -CSPGY 1808
C GY
Sbjct: 247 SCGTGY 252
Score = 44.3 bits (103), Expect = 0.001
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 22/99 (22%)
Query: 1728 GFEGLQAEECGILNGCENGR--------CVRVREGYTC----DCFEGFQLDAAHMACVDV 1775
G+E + C ++ CE+G C + C C GF DA C+D+
Sbjct: 251 GYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGN-CIDI 309
Query: 1776 NECDDLNGPAVLCVHGY-CENTEGSYRC-----HCSPGY 1808
NEC ++ P C G+ C NTEGSY C +C GY
Sbjct: 310 NECLSISAP---CPIGHTCINTEGSYTCQKNVPNCGRGY 345
Score = 44.3 bits (103), Expect = 0.001
Identities = 25/65 (38%), Positives = 35/65 (53%), Gaps = 7/65 (10%)
Query: 605 QLECPQGYKRLNLTHCQDINECLTLGL-CKDAE-CVNTRGSYLC-----TCRPGLMLDPS 657
+L+C G+ + L +C DINECL++ C C+NT GSY C C G L+
Sbjct: 291 KLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEE 350
Query: 658 RSRCV 662
+RCV
Sbjct: 351 GTRCV 355
Score = 42.4 bits (98), Expect = 0.004
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 1732 LQAEECGILNGCENG----RCVRVREGYTCDCFEGFQL-DAAHMACVDVNECDDLNGPAV 1786
+ C +N C + C V Y C C G+QL D + C D++EC G +
Sbjct: 434 VDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHI 493
Query: 1787 LCVHGYCENTEGSYRCHC-SPGY 1808
C N GS++C C S GY
Sbjct: 494 CSYR--CINIPGSFQCSCPSSGY 514
Score = 36.6 bits (83), Expect = 0.23
Identities = 17/35 (48%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLML 654
C+DINEC + + EC N GSY C CR G L
Sbjct: 439 CEDINECSSSPCSQ--ECANVYGSYQCYCRRGYQL 471
Score = 36.2 bits (82), Expect = 0.30
Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 6/77 (7%)
Query: 590 APCPPRPASPVIENGQLECPQGYKRLNL--THCQDINECL--TLGLCKDAECVNTRGSYL 645
+PC A+ V + Q C +GY+ ++ C+DI+EC T G C+N GS+
Sbjct: 448 SPCSQECAN-VYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQ 506
Query: 646 CTC-RPGLMLDPSRSRC 661
C+C G L P+ C
Sbjct: 507 CSCPSSGYRLAPNGRNC 523
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/88 (31%), Positives = 40/88 (45%), Gaps = 12/88 (13%)
Query: 608 CPQGYKRLNL-THCQDINECLT-LGLCKDAE-CVNTRGSYLC----TCRPGLMLDPSRS- 659
C GY+ L+ C+D+NEC+T C+ E C+NT GS+ C +C G L S
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSC 260
Query: 660 ----RCVSDKAISMLQGLCYRSLGPGTC 683
C S + +C +LG C
Sbjct: 261 KDIDECESGIHNCLPDFICQNTLGSFRC 288
Score = 31.6 bits (70), Expect = 7.4
Identities = 19/46 (41%), Positives = 25/46 (54%), Gaps = 4/46 (8%)
Query: 605 QLECPQGYKRL--NLTHCQDINECLT-LGLCKDAE-CVNTRGSYLC 646
Q CP RL N +CQDI+EC+T + C E C N +G + C
Sbjct: 506 QCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRC 551
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 224 bits (572), Expect = 5e-58
Identities = 138/432 (31%), Positives = 198/432 (45%), Gaps = 64/432 (14%)
Query: 980 CPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQG 1039
CP G ++S G + C D +EC C+H C N G++ CSC +G
Sbjct: 5092 CPSGFTLDSVGPF---------------CADEDECAAGNPCSHS-CHNAMGTYYCSCPKG 5135
Query: 1040 YEVTSDEKGCQDVDECA-SRASCPTGL-CLNTEGSFACSA-CENGYWVNEDGTACEDLDE 1096
+ +D + CQD+DECA R +C G C NT GS+ C C +G+ DG +C+D++E
Sbjct: 5136 LTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINE 5195
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTV 1155
C C C N GSF C C+ GY+ G C DV+EC Q+ C + CKNT
Sbjct: 5196 CQESSPCHQR-CFNAIGSFHC-GCEPGYQLK--GRKCMDVNECR--QNVCRPDQHCKNTR 5249
Query: 1156 GSYQC--LCPQGFQLANGTVCEDVNECM-GEEHCAPHGECLNSHGSFFCLCAPGFVSAEG 1212
G Y+C LCP G A C D++EC G C + C N+ GS+ C+C G+ S
Sbjct: 5250 GGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV 5309
Query: 1213 GTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYG----- 1267
G C D++EC C NT GSF C+C G + C ++ +YG
Sbjct: 5310 GRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSS 5369
Query: 1268 ------DPVCGTWKCENSPGSY---------------------RCVLGCQPGFHMAPNGD 1300
PV ++ + Y R + P A +
Sbjct: 5370 YNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDT 5429
Query: 1301 CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGA-A 1359
C+DIDEC N C C NT GS++C+C G++++ +G C D++EC CG
Sbjct: 5430 CVDIDECENTDACQHE--CKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNR 5487
Query: 1360 LCENVEGSFLCL 1371
+C N+ GS+ C+
Sbjct: 5488 MCFNMRGSYQCI 5499
Score = 221 bits (562), Expect = 7e-57
Identities = 152/446 (34%), Positives = 203/446 (45%), Gaps = 64/446 (14%)
Query: 907 GSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG 966
G S C G+TL + G C D +EC CS C N G+Y+C C +G + G
Sbjct: 5086 GDRSNQCPSGFTLDSVGPF--CADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADG 5142
Query: 967 H-CQDINEC---RHPGTCPDGR-CVNSPGSYTCLA-CEEGYRGQSG--SCVDVNECLTPG 1018
CQDI+EC RH TC G+ C N+ GSY C+ C G+R S SC D+NEC
Sbjct: 5143 RTCQDIDECALGRH--TCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESS 5200
Query: 1019 VCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFAC-SA 1077
C H +C N GSF C CE GY++ + C DV+EC P C NT G + C
Sbjct: 5201 PC-HQRCFNAIGSFHCGCEPGYQLKG--RKCMDVNECRQNVCRPDQHCKNTRGGYKCIDL 5257
Query: 1078 CENGYWVNEDGTACEDLDECAF-PGVCP-SGVCTNTAGSFSCKDCDGGYRPSPLGDSCED 1135
C NG E+GT C D+DEC C + +C NT GS+ C C GYR +G C D
Sbjct: 5258 CPNGMTKAENGT-CIDIDECKDGTHQCRYNQICENTRGSYRCV-CPRGYRSQGVGRPCMD 5315
Query: 1136 VDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDV----------------- 1177
++ECE C +C NT GS++C+CP G L +G C +
Sbjct: 5316 INECEQVPKPC-AHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLAR 5374
Query: 1178 -----NECMGEEHCAPHGECLNSHGSFFC--------------LCAPGFVSAEGGTSCQD 1218
N ++H + +S+ + C G S +C D
Sbjct: 5375 FSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEG--SEASHDTCVD 5432
Query: 1219 VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCEN 1278
+DEC TD C C NT GS+ C+C G+Q + C DIDEC + C N
Sbjct: 5433 IDECENTDACQH-ECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFN 5491
Query: 1279 SPGSYRCV-LGCQPGFHMAP-NGDCI 1302
GSY+C+ C P + P +G C+
Sbjct: 5492 MRGSYQCIDTPCPPNYQRDPVSGFCL 5517
Score = 217 bits (552), Expect = 9e-56
Identities = 138/406 (33%), Positives = 187/406 (46%), Gaps = 58/406 (14%)
Query: 846 DRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECL--RDPCKGKGRCI 903
D CAAG N C +C N Y C C G + C D +EC R C C
Sbjct: 5109 DECAAG--NPCSH-SCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCD 5165
Query: 904 NRVGSYSCF--CYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYI 961
N +GSY C C G+ + G + CQDINEC++ C +C N GS+HC C+ GY
Sbjct: 5166 NTIGSYRCVVRCGSGFRRTSDGLS--CQDINECQESSPCH-QRCFNAIGSFHCGCEPGY- 5221
Query: 962 MVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCL-ACEEGY-RGQSGSCVDVNECLT-PG 1018
++ C D+NECR PD C N+ G Y C+ C G + ++G+C+D++EC
Sbjct: 5222 QLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTH 5281
Query: 1019 VCAHGK-CTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSA 1077
C + + C N GS+RC C +GY + C D++EC C NT GSF C
Sbjct: 5282 QCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKC-I 5340
Query: 1078 CENGYWVNEDGTACEDLDECAFPGVCPSGV------------------------------ 1107
C G + DG +C L+ G S
Sbjct: 5341 CPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSE 5400
Query: 1108 CTNTAGSFS------CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCL 1161
N+ S S K C G S D+C D+DECE+ + ECKNT GSYQC+
Sbjct: 5401 YRNSRTSLSRTRRTIRKTCPEGSEAS--HDTCVDIDECEN--TDACQHECKNTFGSYQCI 5456
Query: 1162 CPQGFQLA-NGTVCEDVNECMGEE-HCAPHGECLNSHGSFFCLCAP 1205
CP G+QL NG C+D++EC+ + HC P+ C N GS+ C+ P
Sbjct: 5457 CPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502
Score = 215 bits (547), Expect = 4e-55
Identities = 142/457 (31%), Positives = 203/457 (44%), Gaps = 67/457 (14%)
Query: 1120 CDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLA-NGTVCEDVN 1178
C G+ +G C D DEC + C N +G+Y C CP+G +A +G C+D++
Sbjct: 5092 CPSGFTLDSVGPFCADEDECA--AGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDID 5149
Query: 1179 EC-MGEEHCAPHGECLNSHGSFFCL--CAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1235
EC +G C +C N+ GS+ C+ C GF G SCQD++EC + PC C N
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC-HQRCFN 5208
Query: 1236 TEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWK-CENSPGSYRCVLGCQPGFH 1294
GSF+C CE G+Q + +C+D++EC VC + C+N+ G Y+C+ C G
Sbjct: 5209 AIGSFHCGCEPGYQL--KGRKCMDVNECRQN---VCRPDQHCKNTRGGYKCIDLCPNGMT 5263
Query: 1295 MAPNGDCIDIDECANDT-MCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELML 1353
A NG CIDIDEC + T C + C+NT GS+RC+C +G+ G C+D+NECE +
Sbjct: 5264 KAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVP 5323
Query: 1354 AVCGAALCENVEGSFLCLCASD---LEEYDAQEGHCRPRGAGGQSMS------EAPTGDH 1404
C A C N GSF C+C L + + G R G Q S ++
Sbjct: 5324 KPC-AHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVRNNY 5382
Query: 1405 APAP---TRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSE 1461
P YS + + L R C +G+ + D C D E ++
Sbjct: 5383 QPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSE--ASHDTCVDIDECENTD 5440
Query: 1462 ICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDA 1521
C C NT Y C+C PG+
Sbjct: 5441 AC-----------------------------------QHECKNTFGSYQCICPPGYQLTH 5465
Query: 1522 SHKKCEDHDEC--QDLAC-ENGECVNTEGSFHCFCSP 1555
+ K C+D DEC Q++ C N C N GS+ C +P
Sbjct: 5466 NGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTP 5502
Score = 206 bits (525), Expect = 1e-52
Identities = 149/441 (33%), Positives = 202/441 (45%), Gaps = 69/441 (15%)
Query: 872 CSPGYQLHPSQAYCTDDNECLR-DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQD 930
C G+ L +C D++EC +PC C N +G+Y C C G T+A G T CQD
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNPCSHS--CHNAMGTYYCSCPKGLTIAADGRT--CQD 5147
Query: 931 INECE-QPGVCSGGQ-CTNTEGSYHC--ECDQGYIMVRKG-HCQDINECRHPGTCPDGRC 985
I+EC C GQ C NT GSY C C G+ G CQDINEC+ C RC
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQ-RC 5206
Query: 986 VNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGK-CTNLEGSFRC--SCEQGYEV 1042
N+ GS+ C CE GY+ + C+DVNEC VC + C N G ++C C G +
Sbjct: 5207 FNAIGSFHC-GCEPGYQLKGRKCMDVNEC-RQNVCRPDQHCKNTRGGYKCIDLCPNG--M 5262
Query: 1043 TSDEKG-CQDVDEC--ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDEC-A 1098
T E G C D+DEC + +C NT GS+ C C GY G C D++EC
Sbjct: 5263 TKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRC-VCPRGYRSQGVGRPCMDINECEQ 5321
Query: 1099 FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECED----------------- 1141
P C + C+NT GSF C C G G SC ++ +
Sbjct: 5322 VPKPC-AHQCSNTPGSFKC-ICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSPVR 5379
Query: 1142 ----PQSS--------CLGGECKN-------TVGSYQCLCPQGFQLANGTVCEDVNECMG 1182
PQ E +N T + + CP+G + ++ T C D++EC
Sbjct: 5380 NNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDT-CVDIDECEN 5438
Query: 1183 EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGH--CVNTEGSF 1240
+ C EC N+ GS+ C+C PG+ G +CQD+DEC + G + C N GS+
Sbjct: 5439 TDAC--QHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSY 5496
Query: 1241 NCL---CETGFQPSPESGECV 1258
C+ C +Q P SG C+
Sbjct: 5497 QCIDTPCPPNYQRDPVSGFCL 5517
Score = 171 bits (433), Expect = 6e-42
Identities = 126/375 (33%), Positives = 163/375 (43%), Gaps = 66/375 (17%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCV--CSPGYQLHPSQAYCTDDNECLR-DPCKGKGR 901
ID CA G C N YRCV C G++ C D NEC PC R
Sbjct: 5148 IDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPC--HQR 5205
Query: 902 CINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQ-CTNTEGSYHC--ECDQ 958
C N +GS+ C C PGY L ++C D+NEC Q VC Q C NT G Y C C
Sbjct: 5206 CFNAIGSFHCGCEPGYQL----KGRKCMDVNECRQ-NVCRPDQHCKNTRGGYKCIDLCPN 5260
Query: 959 GYIMVRKGHCQDINECRHPGT--CPDGR-CVNSPGSYTCLACEEGYRGQ--SGSCVDVNE 1013
G G C DI+EC+ GT C + C N+ GSY C+ C GYR Q C+D+NE
Sbjct: 5261 GMTKAENGTCIDIDECK-DGTHQCRYNQICENTRGSYRCV-CPRGYRSQGVGRPCMDINE 5318
Query: 1014 C-LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCL----- 1067
C P CAH +C+N GSF+C C G + D K C ++ + + + L
Sbjct: 5319 CEQVPKPCAH-QCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFSP 5377
Query: 1068 -------------------------NTEGSFACS------ACENGYWVNEDGTACEDLDE 1096
N+ S + + C G + D C D+DE
Sbjct: 5378 VRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHD--TCVDIDE 5435
Query: 1097 CAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGE-CKNTV 1155
C C C NT GS+ C C GY+ + G +C+D+DEC + C C N
Sbjct: 5436 CENTDAC-QHECKNTFGSYQC-ICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMR 5493
Query: 1156 GSYQCL---CPQGFQ 1167
GSYQC+ CP +Q
Sbjct: 5494 GSYQCIDTPCPPNYQ 5508
Score = 86.7 bits (213), Expect = 2e-16
Identities = 120/466 (25%), Positives = 175/466 (37%), Gaps = 86/466 (18%)
Query: 1232 HCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQP 1291
H ++G + C +GF C D DEC G+P + C N+ G+Y C C
Sbjct: 5080 HASISKGDRSNQCPSGFTLDSVGPFCADEDECA-AGNPC--SHSCHNAMGTYYC--SCPK 5134
Query: 1292 GFHMAPNG-DCIDIDECA-NDTMCGSHGFCDNTDGSFRCL--CDQGFEISPSGWDCVDVN 1347
G +A +G C DIDECA C + CDNT GS+RC+ C GF + G C D+N
Sbjct: 5135 GLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDIN 5194
Query: 1348 ECELMLAVCGAALCENVEGSFLCLC----------ASDLEEYDAQ----EGHCRPRGAGG 1393
EC+ + C C N GSF C C D+ E + HC+ G
Sbjct: 5195 ECQ-ESSPCHQR-CFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGY 5252
Query: 1394 QSMSEAPTG-DHAPAPTRMDCYSGQKGHAPC--SSVLGRNTTQAECCCTQG-ASWG---- 1445
+ + P G A T +D + G C + + C C +G S G
Sbjct: 5253 KCIDLCPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRP 5312
Query: 1446 ----DACDLCP-------SEDSAEFSEICP-------SGKGYIPVEGAWTFGQTMYTDAD 1487
+ C+ P S F ICP GK +E +G T Y+ +
Sbjct: 5313 CMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYG-TQYSSYN 5371
Query: 1488 ECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDAS-----------HKKCEDHDE----- 1531
F P + N + Y L + Y S K C + E
Sbjct: 5372 -LARFSP-VRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDT 5429
Query: 1532 CQDL-ACEN-----GECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMD- 1584
C D+ CEN EC NT GS+ C C P L + + C + ++ + ++H
Sbjct: 5430 CVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQD----IDECLEQNVHCGP 5485
Query: 1585 --ICWKKVTNDVCSE---PLRGHRTTYTECCCQDGEAWSQQCALCP 1625
+C+ + C + P R + C ++ +CAL P
Sbjct: 5486 NRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSP 5531
Score = 80.5 bits (197), Expect = 1e-14
Identities = 91/351 (25%), Positives = 136/351 (38%), Gaps = 63/351 (17%)
Query: 1485 DADECVIFGPGLCPNGR-CLNTVPGYVCL--CNPGFHYDASHKKCEDHDECQDLACENGE 1541
D DEC + G C G+ C NT+ Y C+ C GF + C+D +ECQ+ + +
Sbjct: 5147 DIDECAL-GRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESSPCHQR 5205
Query: 1542 CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIH----------MDIC---WK 1588
C N GSFHC C P L ++CM+ +++ D H +D+C
Sbjct: 5206 CFNAIGSFHCGCEPGY--QLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMT 5263
Query: 1589 KVTNDVC---SEPLRG-HRTTYTECCCQDGEAWSQQCALCPP--RSSEVYAQLCNVARIE 1642
K N C E G H+ Y + C + S +C +CP RS V ++ E
Sbjct: 5264 KAENGTCIDIDECKDGTHQCRYNQIC--ENTRGSYRC-VCPRGYRSQGVGRPCMDINECE 5320
Query: 1643 AEREAGVHF---RPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPEDTVPEPAFPNTAGHSA 1699
+ H PG P H G A + +P ++ + A
Sbjct: 5321 QVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGL-------ERLPNYGTQYSSYNLA 5373
Query: 1700 DRTPILES--PLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTC 1757
+P+ + P Q H +S+ E L I C G
Sbjct: 5374 RFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGS---------- 5423
Query: 1758 DCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
+A+H CVD++EC++ + C H C+NT GSY+C C PGY
Sbjct: 5424 --------EASHDTCVDIDECENTDA----CQHE-CKNTFGSYQCICPPGY 5461
Score = 63.9 bits (154), Expect = 1e-09
Identities = 86/328 (26%), Positives = 111/328 (33%), Gaps = 55/328 (16%)
Query: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLC--TCRPGLMLDPSRS-----R 660
C GY+ L C D+NEC D C NTRG Y C C G+ + +
Sbjct: 5217 CEPGYQ-LKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDE 5275
Query: 661 CVSDKAISMLQGLCYRSLGPGTCTLPLAQRI------TKQICCCSRVGKAWGSECEKCPL 714
C +C + G C P R I C +V K +C P
Sbjct: 5276 CKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTP- 5334
Query: 715 PGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLR 774
+F+ ICP G L L R P Q SS L A P+R
Sbjct: 5335 ---GSFKCICPPGQ---------HLLGDGKSCAGLERLPNYGTQYSSYNL---ARFSPVR 5379
Query: 775 VVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPST 834
P + Q + +S + + T+ + I + E S
Sbjct: 5380 --------NNYQPQQHYRQYSHLYSSYSE----YRNSRTSLSRTRRTIRKTCPEGSEASH 5427
Query: 835 DVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRD 894
D V ID C T+ C C N Y+C+C PGYQL + C D +ECL
Sbjct: 5428 DTCV-----DIDECE--NTDAC-QHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQ 5479
Query: 895 --PCKGKGRCINRVGSYSCF---CYPGY 917
C C N GSY C C P Y
Sbjct: 5480 NVHCGPNRMCFNMRGSYQCIDTPCPPNY 5507
Score = 52.8 bits (125), Expect = 3e-06
Identities = 97/447 (21%), Positives = 152/447 (34%), Gaps = 64/447 (14%)
Query: 607 ECPQGYKRLNL-THCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
+CP G+ ++ C D +EC C + C N G+Y C+C GL + C
Sbjct: 5091 QCPSGFTLDSVGPFCADEDECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDID 5149
Query: 666 AISMLQGLCY------RSLGPGTCTLPLAQ--RITKQICCCSRVGKAWGSECEKCPLPGT 717
++ + C+ ++G C + R T C + +EC++
Sbjct: 5150 ECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDI-----NECQESSPCHQ 5204
Query: 718 EAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQPLRVVT 777
F I G + +L RK + R + + G + L
Sbjct: 5205 RCFNAI---GSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNG 5261
Query: 778 DTWLEAGTIPDKGDSQAG-------QVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQV 830
T E GT D + + G Q+ + + V + +I E +
Sbjct: 5262 MTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQ 5321
Query: 831 TPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNE 890
P +TPG +C +C PG + L DG C G + P+
Sbjct: 5322 VPKPCAHQCSNTPGSFKC------ICPPGQHL-LGDGKSCA---GLERLPNYGTQYSSYN 5371
Query: 891 CLR-DPCKGKGRCINRVGSYSCFCYPGYTLATSGAT----------QECQDINECEQPGV 939
R P + + YS Y Y+ + T + C + +E
Sbjct: 5372 LARFSPVRNNYQPQQHYRQYS-HLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTC 5430
Query: 940 CSGGQCTNTE----------GSYHCECDQGYIMVRKGH-CQDINECRHPGT-C-PDGRCV 986
+C NT+ GSY C C GY + G CQDI+EC C P+ C
Sbjct: 5431 VDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCF 5490
Query: 987 NSPGSYTCL--ACEEGYRGQ--SGSCV 1009
N GSY C+ C Y+ SG C+
Sbjct: 5491 NMRGSYQCIDTPCPPNYQRDPVSGFCL 5517
Score = 42.0 bits (97), Expect = 0.005
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 1735 EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCE 1794
+EC N C + C Y C C +G + A C D++EC G C+
Sbjct: 5109 DECAAGNPCSHS-CHNAMGTYYCSCPKGLTIAADGRTCQDIDEC--ALGRHTCHAGQDCD 5165
Query: 1795 NTEGSYRC--HCSPGY 1808
NT GSYRC C G+
Sbjct: 5166 NTIGSYRCVVRCGSGF 5181
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/69 (40%), Positives = 34/69 (49%), Gaps = 12/69 (17%)
Query: 605 QLECPQGYKRLNLTH----CQDINECLTLGL-C-KDAECVNTRGSYLC---TCRPGLMLD 655
Q CP GY+ LTH CQDI+ECL + C + C N RGSY C C P D
Sbjct: 5454 QCICPPGYQ---LTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRD 5510
Query: 656 PSRSRCVSD 664
P C+ +
Sbjct: 5511 PVSGFCLKN 5519
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/59 (35%), Positives = 24/59 (40%), Gaps = 5/59 (8%)
Query: 1759 CFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHC 1817
C GF LD+ C D +EC N C H C N G+Y C C G A C
Sbjct: 5092 CPSGFTLDSVGPFCADEDECAAGNP----CSHS-CHNAMGTYYCSCPKGLTIAADGRTC 5145
Score = 33.9 bits (76), Expect = 1.5
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 10/60 (16%)
Query: 845 IDRCAAGATNVCGPGT-CVNLPDGYRCV---CSPGYQLHPSQAYC-----TDDNECLRDP 895
ID C + CGP C N+ Y+C+ C P YQ P +C +D EC P
Sbjct: 5473 IDECLEQNVH-CGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSP 5531
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 218 bits (554), Expect = 6e-56
Identities = 131/403 (32%), Positives = 185/403 (45%), Gaps = 15/403 (3%)
Query: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920
C+N+P Y C C GY L+ Q C + C + + C+N GS+ C CY GY LA
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
Query: 921 TSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM-VRKGHCQDINECRHPGT 979
G + C ++ C +C N +GSY C+C +G+ + K C I+ C
Sbjct: 313 EDG--KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
Query: 980 CPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035
CVN+ SY+C C +G+ +C +N C PG C H +C N+E S+ C
Sbjct: 371 GCQHECVNTDDSYSC-HCLKGFTLNPDKKTCRRINYCALNKPG-CEH-ECVNMEESYYCR 427
Query: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLD 1095
C +GY + + K C VD CA + LCLNTE SF C C G+ +NED C +D
Sbjct: 428 CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTCSRVD 486
Query: 1096 ECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
C C N SF+C+ C G+ G +C +D C C C ++
Sbjct: 487 YCLLSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC-EHSCVSSE 544
Query: 1156 GSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGT 1214
S+ C C +G+ L +G C + C +H H C+NS S+ C C GF AE G
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGK 603
Query: 1215 SCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGEC 1257
C+ D C +T CVN S+ C C GF + + C
Sbjct: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 206 bits (525), Expect = 1e-52
Identities = 134/419 (31%), Positives = 182/419 (43%), Gaps = 35/419 (8%)
Query: 945 CTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCP------DGRCVNSPGSYTCLACE 998
C N GSY C C QGYI+ D CR C + CVN PGS+ C C
Sbjct: 253 CINIPGSYVCRCKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCY 306
Query: 999 EGYR-GQSGS-CVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
GY + G CV V+ C + +C N +GS+ C C +G+ + D+K C +D CA
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
Query: 1057 SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFS 1116
S C+NT+ S++C C G+ +N D C ++ CA C N S+
Sbjct: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 1117 CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCED 1176
C+ C GY P G +C VD C C C NT S+ C C +GF + ED
Sbjct: 426 CR-CHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF-----LINED 478
Query: 1177 VNECMGEEHC--APHG---ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGG 1231
+ C ++C + HG C+N SF C C G V G +C +D CA D
Sbjct: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Query: 1232 HCVNTEGSFNCLCETGFQPSPESGECVDIDECE--DYGDPVCGTWKCENSPGSYRCVLGC 1289
CV++E SF C C G+ + C D C+ D+G C NS SY C C
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI----CVNSDDSYTCE--C 592
Query: 1290 QPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348
GF +A +G + T G C N S+ C C +GF ++ G C E
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
Score = 198 bits (504), Expect = 3e-50
Identities = 124/407 (30%), Positives = 183/407 (44%), Gaps = 25/407 (6%)
Query: 902 CINRVGSYSCFCYPGYTLATSGATQECQDI-----NECEQPGVCSGGQCTNTEGSYHCEC 956
CIN GSY C C GY L + T QD+ + CEQ C N GS+ C+C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-------LCVNVPGSFVCQC 305
Query: 957 DQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNE 1013
GY + G C ++ C + CVN+ GSY C C EG+ +C ++
Sbjct: 306 YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEGFALNPDKKTCTKIDY 364
Query: 1014 CLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSF 1073
C + +C N + S+ C C +G+ + D+K C+ ++ CA C+N E S+
Sbjct: 365 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESY 424
Query: 1074 ACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSC 1133
C C GY ++ +G C +D CA +C NT SF C+ C G+ + +C
Sbjct: 425 YCR-CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTC 482
Query: 1134 EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGEC 1192
VD C C C N S+ C CP+G L ++G C ++ C +H H C
Sbjct: 483 SRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-C 540
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252
++S SF C C G++ E G +C+ D C D CVN++ S+ C C GF+ +
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 1253 ESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG 1299
+ C D C+ C N+ SY C C GF +A +G
Sbjct: 601 DGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC--KCSEGFVLAEDG 643
Score = 194 bits (493), Expect = 7e-49
Identities = 126/396 (31%), Positives = 175/396 (44%), Gaps = 21/396 (5%)
Query: 985 CVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCA------HGKCTNLEGSFRCSCEQ 1038
C+N PGSY C C++GY S D C +CA C N+ GSF C C
Sbjct: 253 CINIPGSYVC-RCKQGYILNS----DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307
Query: 1039 GYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA 1098
GY + D K C VD CAS C+N +GS+ C C G+ +N D C +D CA
Sbjct: 308 GYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCA 366
Query: 1099 FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY 1158
C NT S+SC C G+ +P +C ++ C + C EC N SY
Sbjct: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESY 424
Query: 1159 QCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217
C C +G+ L NG C V+ C ++H CLN+ SF C C+ GF+ E +C
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 1218 DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCE 1277
VD C +D CVN + SF C C G + C +D C GD C C
Sbjct: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHSCV 541
Query: 1278 NSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEIS 1337
+S S+ C C G+ + +G + G C N+D S+ C C +GF ++
Sbjct: 542 SSEDSFVCQ--CFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599
Query: 1338 PSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373
G C + C+ C +C N S++C C+
Sbjct: 600 EDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCS 634
Score = 189 bits (480), Expect = 2e-47
Identities = 121/360 (33%), Positives = 168/360 (46%), Gaps = 23/360 (6%)
Query: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079
CAH C N+ GS+ C C+QGY + SD+ C+ D CA LC+N GSF C C
Sbjct: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ-CY 306
Query: 1080 NGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDEC 1139
+GY + EDG C +D CA C N GS+ C+ C G+ +P +C +D C
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYC 365
Query: 1140 EDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGS 1198
C EC NT SY C C +GF L + C +N C + H EC+N S
Sbjct: 366 ASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEES 423
Query: 1199 FFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258
++C C G+ G +C VD CA D C+NTE SF C C GF + + C
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 1259 DIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGS 1315
+D C D+G C + C N S+ C C G + +G C +D CA G
Sbjct: 484 RVDYCLLSDHG---C-EYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSCA----LGD 533
Query: 1316 HG---FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC 1372
HG C +++ SF C C +G+ + G C + C+ + C +C N + S+ C C
Sbjct: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCEC 592
Score = 167 bits (424), Expect = 7e-41
Identities = 141/474 (29%), Positives = 188/474 (39%), Gaps = 75/474 (15%)
Query: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
C N GS+ C+ C GY + +C D C +C C N GS+ C C G+
Sbjct: 253 CINIPGSYVCR-CKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
Query: 1168 LA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTD 1226
LA +G C V+ C E H H EC+N+ GS+ C C GF +C +D CA+++
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
Query: 1227 PCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV 1286
CVNT+ S++C C GF +P+ C I+ C P C +C N SY C
Sbjct: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA-LNKPGC-EHECVNMEESYYC- 426
Query: 1287 LGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345
C G+ + PNG C +D CA G C NT+ SF C C +GF I+ C
Sbjct: 427 -RCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
Query: 1346 VNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQSMSEAPTGDH 1404
V+ C L C + C N++ SF C C EGH R G + GDH
Sbjct: 485 VDYCLLSDHGCEYS-CVNMDRSFACQCP---------EGHVLRSDGKTCAKLDSCALGDH 534
Query: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
E C S+E S +C
Sbjct: 535 G----------------------------CEHSCV----------------SSEDSFVCQ 550
Query: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524
+GYI E T + D C G C + C+N+ Y C C GF K
Sbjct: 551 CFEGYILREDGKTCRRK-----DVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
Query: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDL 1576
+C D C+ CE+ CVN S+ C CS L +RC T DL
Sbjct: 604 RCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
Score = 97.8 bits (242), Expect = 8e-20
Identities = 104/437 (23%), Positives = 167/437 (38%), Gaps = 66/437 (15%)
Query: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDEC--EDYGDPVCGTWKCENS 1279
C+T + C+N GS+ C C+ G+ + + C D C ED+ C C N
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---C-EQLCVNV 297
Query: 1280 PGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISP 1338
PGS+ C C G+ +A +G C+ +D CA++ G C N DGS+ C C +GF ++P
Sbjct: 298 PGSFVC--QCYSGYALAEDGKRCVAVDYCASENH-GCEHECVNADGSYLCQCHEGFALNP 354
Query: 1339 SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL-----EEYDAQEGHCRPRGAGG 1393
C ++ C C C N + S+ C C ++ + +C G
Sbjct: 355 DKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
Query: 1394 Q----SMSEA---------PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440
+ +M E+ + +R+D + Q+ H C + C C++
Sbjct: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVD-HCAQQDHG-CEQLCLNTEDSFVCQCSE 471
Query: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTF------GQTMYTDADECV---- 1490
G + C D S+ G Y V +F G + +D C
Sbjct: 472 GFLINEDLKTCSRVDYCLLSD---HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
Query: 1491 -IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--DLACENGECVNTEG 1547
G C + C+++ +VC C G+ K C D CQ D CE+ CVN++
Sbjct: 529 CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDD 586
Query: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607
S+ C C L +RC D+C K T+ C + +Y
Sbjct: 587 SYTCECLEGFRLAEDGKRCRRK--------------DVC--KSTHHGCEHICVNNGNSYI 630
Query: 1608 ECCCQDGEAWSQQCALC 1624
C C +G ++ C
Sbjct: 631 -CKCSEGFVLAEDGRRC 646
Score = 70.9 bits (172), Expect = 1e-11
Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919
+CVN+ + C C G+ L C + C + C++ S+ C C+ GY L
Sbjct: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYIL 557
Query: 920 ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPG 978
G T +D+ + G C C N++ SY CEC +G+ + G C+ + C+
Sbjct: 558 REDGKTCRRKDVCQAIDHG-CE-HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
Query: 979 TCPDGRCVNSPGSYTCLACEEGY 1001
+ CVN+ SY C C EG+
Sbjct: 616 HGCEHICVNNGNSYIC-KCSEGF 637
Score = 52.8 bits (125), Expect = 3e-06
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV Y C C EGF L+ C ++ C N C H C NT+ SY
Sbjct: 329 HGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVNTDDSY 383
Query: 1801 RCHCSPGYVAEAGPPHC 1817
CHC G+ C
Sbjct: 384 SCHCLKGFTLNPDKKTC 400
Score = 52.0 bits (123), Expect = 5e-06
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GC++ CV + Y+C C +GF L+ C +N C LN P C H C N E SY
Sbjct: 370 HGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC-ALNKPG--CEH-ECVNMEESY 424
Query: 1801 RCHCSPGYVAEAGPPHCT 1818
C C GY + C+
Sbjct: 425 YCRCHRGYTLDPNGKTCS 442
Score = 48.5 bits (114), Expect = 6e-05
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 11/80 (13%)
Query: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTEG 1798
GCE+ CV + E Y C C G+ LD C V+ C + HG C NTE
Sbjct: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD-------HGCEQLCLNTED 463
Query: 1799 SYRCHCSPGYVAEAGPPHCT 1818
S+ C CS G++ C+
Sbjct: 464 SFVCQCSEGFLINEDLKTCS 483
Score = 47.0 bits (110), Expect = 2e-04
Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+ CE CV V + C C+ G+ L CV V+ C N C H C N +GSY
Sbjct: 288 HNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG---CEH-ECVNADGSY 342
Query: 1801 RCHCSPGYVAEAGPPHCT 1818
C C G+ CT
Sbjct: 343 LCQCHEGFALNPDKKTCT 360
Score = 46.6 bits (109), Expect = 2e-04
Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV + YTC+C EGF+L C + C + C H C N SY
Sbjct: 575 HGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEH-ICVNNGNSY 629
Query: 1801 RCHCSPGYV-AEAG 1813
C CS G+V AE G
Sbjct: 630 ICKCSEGFVLAEDG 643
Score = 44.7 bits (104), Expect = 8e-04
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV + + C CFEG+ L C + C ++ C H C N++ SY
Sbjct: 534 HGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG---CEH-ICVNSDDSY 588
Query: 1801 RCHCSPGYVAEAGPPHCTAKE 1821
C C G+ C K+
Sbjct: 589 TCECLEGFRLAEDGKRCRRKD 609
Score = 44.3 bits (103), Expect = 0.001
Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 6/115 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS-DKAISMLQG---LCY 675
C+ IN C + ECVN SY C C G LDP+ C D G LC
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
Query: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFREICPAGH 728
+ C I + + CSRV S+ CE + +F CP GH
Sbjct: 460 NTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH 514
Score = 41.6 bits (96), Expect = 0.007
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
+GCE C+ + + C C EGF ++ C V+ C +L HG C N +
Sbjct: 452 HGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-------LLSDHGCEYSCVNMD 503
Query: 1798 GSYRCHCSPGYVAEAGPPHC 1817
S+ C C G+V + C
Sbjct: 504 RSFACQCPEGHVLRSDGKTC 523
Score = 40.4 bits (93), Expect = 0.016
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 11/84 (13%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
+GCE CV + + C C EG L + C ++ C L HG C ++E
Sbjct: 493 HGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-------ALGDHGCEHSCVSSE 544
Query: 1798 GSYRCHCSPGYVAEAGPPHCTAKE 1821
S+ C C GY+ C K+
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKD 568
Score = 40.0 bits (92), Expect = 0.021
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 11/61 (18%)
Query: 607 ECPQGYKRLNLTHCQDINECLTLGLCK------DAECVNTRGSYLCTCRPGLMLDPSRSR 660
+C GY +D C+ + C + ECVN GSYLC C G L+P +
Sbjct: 304 QCYSGYAL-----AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKT 358
Query: 661 C 661
C
Sbjct: 359 C 359
Score = 37.0 bits (84), Expect = 0.18
Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 8/74 (10%)
Query: 1748 CVRVREGYTCDCFEGFQLDAAHMAC--VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCS 1805
C+ + Y C C +G+ L++ C D+ +D N + C N GS+ C C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL------CVNVPGSFVCQCY 306
Query: 1806 PGYVAEAGPPHCTA 1819
GY C A
Sbjct: 307 SGYALAEDGKRCVA 320
Score = 35.8 bits (81), Expect = 0.39
Identities = 16/42 (38%), Positives = 20/42 (47%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
C I+ C + ECVNT SY C C G L+P + C
Sbjct: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Score = 33.5 bits (75), Expect = 1.9
Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 11/61 (18%)
Query: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAE------CVNTRGSYLCTCRPGLMLDPSRSR 660
EC +G++ +D C +CK CVN SY+C C G +L R
Sbjct: 591 ECLEGFRL-----AEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRR 645
Query: 661 C 661
C
Sbjct: 646 C 646
Score = 32.7 bits (73), Expect = 3.3
Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 608 CPQGY-KRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS 663
C QGY + T C+ + C + CVN GS++C C G L RCV+
Sbjct: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVA 320
Score = 32.0 bits (71), Expect = 5.6
Identities = 10/25 (40%), Positives = 17/25 (68%)
Query: 637 CVNTRGSYLCTCRPGLMLDPSRSRC 661
C+N GSY+C C+ G +L+ ++ C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTC 277
Score = 31.6 bits (70), Expect = 7.4
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
C H +C N GSY C C GY+ + C ++
Sbjct: 249 CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQD 281
Score = 31.2 bits (69), Expect = 9.6
Identities = 30/139 (21%), Positives = 52/139 (37%), Gaps = 9/139 (6%)
Query: 607 ECPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
+CP+G+ R + C ++ C + CV++ S++C C G +L C
Sbjct: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
Query: 666 AISML----QGLCYRSLGPGTCTLPLAQRITKQICCCSR--VGKAWGSECEKCPLPGTEA 719
+ + +C S TC R+ + C R V K+ CE + +
Sbjct: 569 VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
Query: 720 FREICPAGHGYTYASSDIR 738
+ IC G+ A R
Sbjct: 629 Y--ICKCSEGFVLAEDGRR 645
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 218 bits (554), Expect = 6e-56
Identities = 131/403 (32%), Positives = 185/403 (45%), Gaps = 15/403 (3%)
Query: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLA 920
C+N+P Y C C GY L+ Q C + C + + C+N GS+ C CY GY LA
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 312
Query: 921 TSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM-VRKGHCQDINECRHPGT 979
G + C ++ C +C N +GSY C+C +G+ + K C I+ C
Sbjct: 313 EDG--KRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNH 370
Query: 980 CPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNECLT--PGVCAHGKCTNLEGSFRCS 1035
CVN+ SY+C C +G+ +C +N C PG C H +C N+E S+ C
Sbjct: 371 GCQHECVNTDDSYSC-HCLKGFTLNPDKKTCRRINYCALNKPG-CEH-ECVNMEESYYCR 427
Query: 1036 CEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLD 1095
C +GY + + K C VD CA + LCLNTE SF C C G+ +NED C +D
Sbjct: 428 CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTCSRVD 486
Query: 1096 ECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTV 1155
C C N SF+C+ C G+ G +C +D C C C ++
Sbjct: 487 YCLLSDHGCEYSCVNMDRSFACQ-CPEGHVLRSDGKTCAKLDSCALGDHGC-EHSCVSSE 544
Query: 1156 GSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGT 1214
S+ C C +G+ L +G C + C +H H C+NS S+ C C GF AE G
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDDSYTCECLEGFRLAEDGK 603
Query: 1215 SCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGEC 1257
C+ D C +T CVN S+ C C GF + + C
Sbjct: 604 RCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 646
Score = 206 bits (525), Expect = 1e-52
Identities = 134/419 (31%), Positives = 182/419 (43%), Gaps = 35/419 (8%)
Query: 945 CTNTEGSYHCECDQGYIMVRKGHCQDINECRHPGTCP------DGRCVNSPGSYTCLACE 998
C N GSY C C QGYI+ D CR C + CVN PGS+ C C
Sbjct: 253 CINIPGSYVCRCKQGYILN-----SDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVC-QCY 306
Query: 999 EGYR-GQSGS-CVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECA 1056
GY + G CV V+ C + +C N +GS+ C C +G+ + D+K C +D CA
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTKIDYCA 366
Query: 1057 SRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFS 1116
S C+NT+ S++C C G+ +N D C ++ CA C N S+
Sbjct: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYY 425
Query: 1117 CKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCED 1176
C+ C GY P G +C VD C C C NT S+ C C +GF + ED
Sbjct: 426 CR-CHRGYTLDPNGKTCSRVDHCAQQDHGC-EQLCLNTEDSFVCQCSEGF-----LINED 478
Query: 1177 VNECMGEEHC--APHG---ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGG 1231
+ C ++C + HG C+N SF C C G V G +C +D CA D
Sbjct: 479 LKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEH 538
Query: 1232 HCVNTEGSFNCLCETGFQPSPESGECVDIDECE--DYGDPVCGTWKCENSPGSYRCVLGC 1289
CV++E SF C C G+ + C D C+ D+G C NS SY C C
Sbjct: 539 SCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHI----CVNSDDSYTCE--C 592
Query: 1290 QPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNE 1348
GF +A +G + T G C N S+ C C +GF ++ G C E
Sbjct: 593 LEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRCKKCTE 651
Score = 198 bits (504), Expect = 3e-50
Identities = 124/407 (30%), Positives = 183/407 (44%), Gaps = 25/407 (6%)
Query: 902 CINRVGSYSCFCYPGYTLATSGATQECQDI-----NECEQPGVCSGGQCTNTEGSYHCEC 956
CIN GSY C C GY L + T QD+ + CEQ C N GS+ C+C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQ-------LCVNVPGSFVCQC 305
Query: 957 DQGYIMVRKG-HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY--RGQSGSCVDVNE 1013
GY + G C ++ C + CVN+ GSY C C EG+ +C ++
Sbjct: 306 YSGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLC-QCHEGFALNPDKKTCTKIDY 364
Query: 1014 CLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSF 1073
C + +C N + S+ C C +G+ + D+K C+ ++ CA C+N E S+
Sbjct: 365 CASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESY 424
Query: 1074 ACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSC 1133
C C GY ++ +G C +D CA +C NT SF C+ C G+ + +C
Sbjct: 425 YCR-CHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQ-CSEGFLINEDLKTC 482
Query: 1134 EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGEC 1192
VD C C C N S+ C CP+G L ++G C ++ C +H H C
Sbjct: 483 SRVDYCLLSDHGC-EYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHS-C 540
Query: 1193 LNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSP 1252
++S SF C C G++ E G +C+ D C D CVN++ S+ C C GF+ +
Sbjct: 541 VSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAE 600
Query: 1253 ESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG 1299
+ C D C+ C N+ SY C C GF +A +G
Sbjct: 601 DGKRCRRKDVCKSTHHGC--EHICVNNGNSYIC--KCSEGFVLAEDG 643
Score = 194 bits (493), Expect = 7e-49
Identities = 126/396 (31%), Positives = 175/396 (44%), Gaps = 21/396 (5%)
Query: 985 CVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCA------HGKCTNLEGSFRCSCEQ 1038
C+N PGSY C C++GY S D C +CA C N+ GSF C C
Sbjct: 253 CINIPGSYVC-RCKQGYILNS----DQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYS 307
Query: 1039 GYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECA 1098
GY + D K C VD CAS C+N +GS+ C C G+ +N D C +D CA
Sbjct: 308 GYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYCA 366
Query: 1099 FPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSY 1158
C NT S+SC C G+ +P +C ++ C + C EC N SY
Sbjct: 367 SSNHGCQHECVNTDDSYSCH-CLKGFTLNPDKKTCRRINYCALNKPGC-EHECVNMEESY 424
Query: 1159 QCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217
C C +G+ L NG C V+ C ++H CLN+ SF C C+ GF+ E +C
Sbjct: 425 YCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 1218 DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCE 1277
VD C +D CVN + SF C C G + C +D C GD C C
Sbjct: 484 RVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCA-LGDHGC-EHSCV 541
Query: 1278 NSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEIS 1337
+S S+ C C G+ + +G + G C N+D S+ C C +GF ++
Sbjct: 542 SSEDSFVCQ--CFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLA 599
Query: 1338 PSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCA 1373
G C + C+ C +C N S++C C+
Sbjct: 600 EDGKRCRRKDVCKSTHHGC-EHICVNNGNSYICKCS 634
Score = 189 bits (480), Expect = 2e-47
Identities = 121/360 (33%), Positives = 168/360 (46%), Gaps = 23/360 (6%)
Query: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079
CAH C N+ GS+ C C+QGY + SD+ C+ D CA LC+N GSF C C
Sbjct: 249 CAHF-CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQ-CY 306
Query: 1080 NGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDEC 1139
+GY + EDG C +D CA C N GS+ C+ C G+ +P +C +D C
Sbjct: 307 SGYALAEDGKRCVAVDYCASENHGCEHECVNADGSYLCQ-CHEGFALNPDKKTCTKIDYC 365
Query: 1140 EDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGS 1198
C EC NT SY C C +GF L + C +N C + H EC+N S
Sbjct: 366 ASSNHGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEH-ECVNMEES 423
Query: 1199 FFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258
++C C G+ G +C VD CA D C+NTE SF C C GF + + C
Sbjct: 424 YYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCLNTEDSFVCQCSEGFLINEDLKTCS 483
Query: 1259 DIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGS 1315
+D C D+G C + C N S+ C C G + +G C +D CA G
Sbjct: 484 RVDYCLLSDHG---C-EYSCVNMDRSFAC--QCPEGHVLRSDGKTCAKLDSCA----LGD 533
Query: 1316 HG---FCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLC 1372
HG C +++ SF C C +G+ + G C + C+ + C +C N + S+ C C
Sbjct: 534 HGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGC-EHICVNSDDSYTCEC 592
Score = 167 bits (424), Expect = 7e-41
Identities = 141/474 (29%), Positives = 188/474 (39%), Gaps = 75/474 (15%)
Query: 1108 CTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQ 1167
C N GS+ C+ C GY + +C D C +C C N GS+ C C G+
Sbjct: 253 CINIPGSYVCR-CKQGYILNSDQTTCRIQDLCAMEDHNC-EQLCVNVPGSFVCQCYSGYA 310
Query: 1168 LA-NGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTD 1226
LA +G C V+ C E H H EC+N+ GS+ C C GF +C +D CA+++
Sbjct: 311 LAEDGKRCVAVDYCASENHGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSN 369
Query: 1227 PCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCV 1286
CVNT+ S++C C GF +P+ C I+ C P C +C N SY C
Sbjct: 370 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCA-LNKPGC-EHECVNMEESYYC- 426
Query: 1287 LGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD 1345
C G+ + PNG C +D CA G C NT+ SF C C +GF I+ C
Sbjct: 427 -RCHRGYTLDPNGKTCSRVDHCAQQDH-GCEQLCLNTEDSFVCQCSEGFLINEDLKTCSR 484
Query: 1346 VNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC-RPRGAGGQSMSEAPTGDH 1404
V+ C L C + C N++ SF C C EGH R G + GDH
Sbjct: 485 VDYCLLSDHGCEYS-CVNMDRSFACQCP---------EGHVLRSDGKTCAKLDSCALGDH 534
Query: 1405 APAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
E C S+E S +C
Sbjct: 535 G----------------------------CEHSCV----------------SSEDSFVCQ 550
Query: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHK 1524
+GYI E T + D C G C + C+N+ Y C C GF K
Sbjct: 551 CFEGYILREDGKTCRRK-----DVCQAIDHG-CEH-ICVNSDDSYTCECLEGFRLAEDGK 603
Query: 1525 KCEDHDECQDL--ACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDL 1576
+C D C+ CE+ CVN S+ C CS L +RC T DL
Sbjct: 604 RCRRKDVCKSTHHGCEH-ICVNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDL 656
Score = 97.8 bits (242), Expect = 8e-20
Identities = 104/437 (23%), Positives = 167/437 (38%), Gaps = 66/437 (15%)
Query: 1222 CATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDEC--EDYGDPVCGTWKCENS 1279
C+T + C+N GS+ C C+ G+ + + C D C ED+ C C N
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHN---C-EQLCVNV 297
Query: 1280 PGSYRCVLGCQPGFHMAPNGD-CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISP 1338
PGS+ C C G+ +A +G C+ +D CA++ G C N DGS+ C C +GF ++P
Sbjct: 298 PGSFVC--QCYSGYALAEDGKRCVAVDYCASENH-GCEHECVNADGSYLCQCHEGFALNP 354
Query: 1339 SGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL-----EEYDAQEGHCRPRGAGG 1393
C ++ C C C N + S+ C C ++ + +C G
Sbjct: 355 DKKTCTKIDYCASSNHGCQHE-CVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGC 413
Query: 1394 Q----SMSEA---------PTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQ 1440
+ +M E+ + +R+D + Q+ H C + C C++
Sbjct: 414 EHECVNMEESYYCRCHRGYTLDPNGKTCSRVD-HCAQQDHG-CEQLCLNTEDSFVCQCSE 471
Query: 1441 GASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTF------GQTMYTDADECV---- 1490
G + C D S+ G Y V +F G + +D C
Sbjct: 472 GFLINEDLKTCSRVDYCLLSD---HGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLDS 528
Query: 1491 -IFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ--DLACENGECVNTEG 1547
G C + C+++ +VC C G+ K C D CQ D CE+ CVN++
Sbjct: 529 CALGDHGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEH-ICVNSDD 586
Query: 1548 SFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYT 1607
S+ C C L +RC D+C K T+ C + +Y
Sbjct: 587 SYTCECLEGFRLAEDGKRCRRK--------------DVC--KSTHHGCEHICVNNGNSYI 630
Query: 1608 ECCCQDGEAWSQQCALC 1624
C C +G ++ C
Sbjct: 631 -CKCSEGFVLAEDGRRC 646
Score = 70.9 bits (172), Expect = 1e-11
Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 4/143 (2%)
Query: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTL 919
+CVN+ + C C G+ L C + C + C++ S+ C C+ GY L
Sbjct: 498 SCVNMDRSFACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYIL 557
Query: 920 ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG-HCQDINECRHPG 978
G T +D+ + G C C N++ SY CEC +G+ + G C+ + C+
Sbjct: 558 REDGKTCRRKDVCQAIDHG-CE-HICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTH 615
Query: 979 TCPDGRCVNSPGSYTCLACEEGY 1001
+ CVN+ SY C C EG+
Sbjct: 616 HGCEHICVNNGNSYIC-KCSEGF 637
Score = 52.8 bits (125), Expect = 3e-06
Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV Y C C EGF L+ C ++ C N C H C NT+ SY
Sbjct: 329 HGCEH-ECVNADGSYLCQCHEGFALNPDKKTCTKIDYCASSNHG---CQH-ECVNTDDSY 383
Query: 1801 RCHCSPGYVAEAGPPHC 1817
CHC G+ C
Sbjct: 384 SCHCLKGFTLNPDKKTC 400
Score = 52.0 bits (123), Expect = 5e-06
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 5/78 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GC++ CV + Y+C C +GF L+ C +N C LN P C H C N E SY
Sbjct: 370 HGCQH-ECVNTDDSYSCHCLKGFTLNPDKKTCRRINYC-ALNKPG--CEH-ECVNMEESY 424
Query: 1801 RCHCSPGYVAEAGPPHCT 1818
C C GY + C+
Sbjct: 425 YCRCHRGYTLDPNGKTCS 442
Score = 48.5 bits (114), Expect = 6e-05
Identities = 27/80 (33%), Positives = 36/80 (45%), Gaps = 11/80 (13%)
Query: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTEG 1798
GCE+ CV + E Y C C G+ LD C V+ C + HG C NTE
Sbjct: 412 GCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQD-------HGCEQLCLNTED 463
Query: 1799 SYRCHCSPGYVAEAGPPHCT 1818
S+ C CS G++ C+
Sbjct: 464 SFVCQCSEGFLINEDLKTCS 483
Score = 47.0 bits (110), Expect = 2e-04
Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+ CE CV V + C C+ G+ L CV V+ C N C H C N +GSY
Sbjct: 288 HNCEQ-LCVNVPGSFVCQCYSGYALAEDGKRCVAVDYCASENHG---CEH-ECVNADGSY 342
Query: 1801 RCHCSPGYVAEAGPPHCT 1818
C C G+ CT
Sbjct: 343 LCQCHEGFALNPDKKTCT 360
Score = 46.6 bits (109), Expect = 2e-04
Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 6/74 (8%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV + YTC+C EGF+L C + C + C H C N SY
Sbjct: 575 HGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHG---CEH-ICVNNGNSY 629
Query: 1801 RCHCSPGYV-AEAG 1813
C CS G+V AE G
Sbjct: 630 ICKCSEGFVLAEDG 643
Score = 44.7 bits (104), Expect = 8e-04
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 5/81 (6%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSY 1800
+GCE+ CV + + C CFEG+ L C + C ++ C H C N++ SY
Sbjct: 534 HGCEHS-CVSSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHG---CEH-ICVNSDDSY 588
Query: 1801 RCHCSPGYVAEAGPPHCTAKE 1821
C C G+ C K+
Sbjct: 589 TCECLEGFRLAEDGKRCRRKD 609
Score = 44.3 bits (103), Expect = 0.001
Identities = 35/115 (30%), Positives = 44/115 (38%), Gaps = 6/115 (5%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS-DKAISMLQG---LCY 675
C+ IN C + ECVN SY C C G LDP+ C D G LC
Sbjct: 400 CRRINYCALNKPGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLCL 459
Query: 676 RSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE--CEKCPLPGTEAFREICPAGH 728
+ C I + + CSRV S+ CE + +F CP GH
Sbjct: 460 NTEDSFVCQCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGH 514
Score = 41.6 bits (96), Expect = 0.007
Identities = 23/80 (28%), Positives = 35/80 (43%), Gaps = 11/80 (13%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
+GCE C+ + + C C EGF ++ C V+ C +L HG C N +
Sbjct: 452 HGCEQ-LCLNTEDSFVCQCSEGFLINEDLKTCSRVDYC-------LLSDHGCEYSCVNMD 503
Query: 1798 GSYRCHCSPGYVAEAGPPHC 1817
S+ C C G+V + C
Sbjct: 504 RSFACQCPEGHVLRSDGKTC 523
Score = 40.4 bits (93), Expect = 0.016
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 11/84 (13%)
Query: 1741 NGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG---YCENTE 1797
+GCE CV + + C C EG L + C ++ C L HG C ++E
Sbjct: 493 HGCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAKLDSC-------ALGDHGCEHSCVSSE 544
Query: 1798 GSYRCHCSPGYVAEAGPPHCTAKE 1821
S+ C C GY+ C K+
Sbjct: 545 DSFVCQCFEGYILREDGKTCRRKD 568
Score = 40.0 bits (92), Expect = 0.021
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 11/61 (18%)
Query: 607 ECPQGYKRLNLTHCQDINECLTLGLCK------DAECVNTRGSYLCTCRPGLMLDPSRSR 660
+C GY +D C+ + C + ECVN GSYLC C G L+P +
Sbjct: 304 QCYSGYAL-----AEDGKRCVAVDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKT 358
Query: 661 C 661
C
Sbjct: 359 C 359
Score = 37.0 bits (84), Expect = 0.18
Identities = 20/74 (27%), Positives = 30/74 (40%), Gaps = 8/74 (10%)
Query: 1748 CVRVREGYTCDCFEGFQLDAAHMAC--VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCS 1805
C+ + Y C C +G+ L++ C D+ +D N + C N GS+ C C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQL------CVNVPGSFVCQCY 306
Query: 1806 PGYVAEAGPPHCTA 1819
GY C A
Sbjct: 307 SGYALAEDGKRCVA 320
Score = 35.8 bits (81), Expect = 0.39
Identities = 16/42 (38%), Positives = 20/42 (47%)
Query: 620 CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
C I+ C + ECVNT SY C C G L+P + C
Sbjct: 359 CTKIDYCASSNHGCQHECVNTDDSYSCHCLKGFTLNPDKKTC 400
Score = 33.5 bits (75), Expect = 1.9
Identities = 18/61 (29%), Positives = 25/61 (40%), Gaps = 11/61 (18%)
Query: 607 ECPQGYKRLNLTHCQDINECLTLGLCKDAE------CVNTRGSYLCTCRPGLMLDPSRSR 660
EC +G++ +D C +CK CVN SY+C C G +L R
Sbjct: 591 ECLEGFRL-----AEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRR 645
Query: 661 C 661
C
Sbjct: 646 C 646
Score = 32.7 bits (73), Expect = 3.3
Identities = 19/57 (33%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 608 CPQGY-KRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS 663
C QGY + T C+ + C + CVN GS++C C G L RCV+
Sbjct: 264 CKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKRCVA 320
Score = 32.0 bits (71), Expect = 5.6
Identities = 10/25 (40%), Positives = 17/25 (68%)
Query: 637 CVNTRGSYLCTCRPGLMLDPSRSRC 661
C+N GSY+C C+ G +L+ ++ C
Sbjct: 253 CINIPGSYVCRCKQGYILNSDQTTC 277
Score = 31.6 bits (70), Expect = 7.4
Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 1788 CVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAKE 1821
C H +C N GSY C C GY+ + C ++
Sbjct: 249 CAH-FCINIPGSYVCRCKQGYILNSDQTTCRIQD 281
Score = 31.2 bits (69), Expect = 9.6
Identities = 30/139 (21%), Positives = 52/139 (37%), Gaps = 9/139 (6%)
Query: 607 ECPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
+CP+G+ R + C ++ C + CV++ S++C C G +L C
Sbjct: 509 QCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCRRKD 568
Query: 666 AISML----QGLCYRSLGPGTCTLPLAQRITKQICCCSR--VGKAWGSECEKCPLPGTEA 719
+ + +C S TC R+ + C R V K+ CE + +
Sbjct: 569 VCQAIDHGCEHICVNSDDSYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNS 628
Query: 720 FREICPAGHGYTYASSDIR 738
+ IC G+ A R
Sbjct: 629 Y--ICKCSEGFVLAEDGRR 645
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 197 bits (500), Expect = 1e-49
Identities = 207/767 (26%), Positives = 276/767 (35%), Gaps = 143/767 (18%)
Query: 861 CVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN-RVGSYSCFCYPGYTL 919
CVN P Y C C PG++LH C N C + C+ + + C C PG+ L
Sbjct: 176 CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQL 235
Query: 920 ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQDINECRHP- 977
G + C + C +C G CEC GY + G C+D++EC
Sbjct: 236 QEDG--RHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGL 293
Query: 978 GTCPDGRCVNSPGSYTCLACEEGYR-GQSG-SCVD-----VNEC-LTPGVCAHGKCTNLE 1029
C G C+N+ GS+ C+ C GY G G C VN C G C+HG C++
Sbjct: 294 AQCAHG-CLNTQGSFKCV-CHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG-CSHTS 350
Query: 1030 GSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGT 1089
C+C +GYE+ +D++ C DVD+CA C +C N G + C C GY ++ DG
Sbjct: 351 AGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQ-VCTNNPGGYEC-GCYAGYRLSADGC 408
Query: 1090 ACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGG 1149
CED+DECA CTN AGSF C C+ GYR L + E+P L G
Sbjct: 409 GCEDVDECASSRGGCEHHCTNLAGSFQC-SCEAGYR---LHEDRRGCSPLEEPMVD-LDG 463
Query: 1150 ECKNT-----VGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204
E + Q PQ FQ + E+ E GE CL+ C
Sbjct: 464 ELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDC--- 520
Query: 1205 PGFVSAEGGTSCQDVDECATTDPCVGG--HCVNTEGSFNCLCETGFQPSPESGECVDIDE 1262
+C D+C C+ G C EG +C P C
Sbjct: 521 --------SLTC---DDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCS 569
Query: 1263 CEDYG--DPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCD 1320
C++ G D V G +C C GC G++ C C + G C
Sbjct: 570 CQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYG---------KHCRKKCNCANRGRCH 620
Query: 1321 NTDGSFRCLCDQGF-----EISPSGWDCVDVNECELMLAVCGAALCENVEGSFLC----- 1370
G+ CLCD G ++ W E C+ +GS C
Sbjct: 621 RLYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFR 678
Query: 1371 --LCASDLE------------------EYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPT- 1409
C ++ E D+ G C R G + G P T
Sbjct: 679 GERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDC--GQECPVGTF 736
Query: 1410 RMDCYSG-QKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKG 1468
++C S G APC V G +C C G + D CP
Sbjct: 737 GVNCSSSCSCGGAPCHGVTG------QCRCPPGRTGEDCEADCP---------------- 774
Query: 1469 YIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCED 1528
EG W G C P RC + G CLC PGF +C+D
Sbjct: 775 ----EGRWGLG---------CQEICPACQHAARC-DPETG-ACLCLPGF----VGSRCQD 815
Query: 1529 -------HDECQD-LACEN-GECVNTEGSFHCFCSPPLTLDLSQQRC 1566
CQ +C N G C G HC C+P T Q+ C
Sbjct: 816 VCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCAPGWTGFSCQRAC 860
Score = 187 bits (476), Expect = 6e-47
Identities = 197/685 (28%), Positives = 269/685 (39%), Gaps = 89/685 (12%)
Query: 933 ECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGHCQ-DINECR-HPGTCPDGRCVNSPG 990
EC GG+C + C C G+ R CQ D++ECR H G C RCVN+PG
Sbjct: 127 ECSASLCFHGGRCV-PGSAQPCHCPPGFQGPR---CQYDVDECRTHNGGCQH-RCVNTPG 181
Query: 991 SYTCLACEEGYR--GQSGSCVDVNEC-LTPGVCAHGKCTNLEGS-FRCSCEQGYEVTSDE 1046
SY C C+ G+R S +C+ +N C L G C H C L + RC C G+++ D
Sbjct: 182 SYLC-ECKPGFRLHTDSRTCLAINSCALGNGGCQH-HCVQLTITRHRCQCRPGFQLQEDG 239
Query: 1047 KGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFP-GVCPS 1105
+ C CA+R C G C C GY + DG ACED+DECA C
Sbjct: 240 RHCVRRSPCANRNGSCMHRCQVVRGLARCE-CHVGYQLAADGKACEDVDECAAGLAQCAH 298
Query: 1106 GVCTNTAGSFSCKDCDGGYRPSPLGDSC-----EDVDECEDPQSSCLGGECKNTVGSYQC 1160
G C NT GSF C C GY G C E V+ CE C G C +T C
Sbjct: 299 G-CLNTQGSFKCV-CHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG-CSHTSAGPLC 355
Query: 1161 LCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDV 1219
CP+G++L + C DV++C C C N+ G + C C G+ + G C+DV
Sbjct: 356 TCPRGYELDTDQRTCIDVDDCADSPCCQQ--VCTNNPGGYECGCYAGYRLSADGCGCEDV 413
Query: 1220 DECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENS 1279
DECA++ HC N GSF C CE G++ + C ++E D +
Sbjct: 414 DECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVR---- 469
Query: 1280 PGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQ-GFEISP 1338
P + VL Q D + DE + G H + F CL D G + S
Sbjct: 470 PLPHIAVL--QDELPQLFQDDDVGADE-EEAELRGEHTLTE----KFVCLDDSFGHDCSL 522
Query: 1339 SGWDCVDVNECELMLAVCG------AALCENV--------EGSFLCLCASDLEEYDAQEG 1384
+ DC + C L L C +C SF C C + D+ G
Sbjct: 523 TCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDTFGKNCSFSCSCQNG-GTCDSVTG 581
Query: 1385 HCR-PRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGAS 1443
CR P G G + + + R C +G C + G C C G
Sbjct: 582 ACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGR--CHRLYG------ACLCDPGL- 632
Query: 1444 WGDACDL-CP--------SEDS---AEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVI 1491
+G C L CP SE+ ++ C G + + G+ + E
Sbjct: 633 YGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSCKAGFR-GERCQAEC-ELGY 690
Query: 1492 FGPG-----LCPNGRCLNTVPGYV-CLCNPGFHYDASHKKCE----DHDECQDLACENGE 1541
FGPG CP G ++V G C GF + ++C + +C
Sbjct: 691 FGPGCWQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAP 750
Query: 1542 CVNTEGSFHCFCSPPLTLDLSQQRC 1566
C G C C P T + + C
Sbjct: 751 CHGVTG--QCRCPPGRTGEDCEADC 773
Score = 134 bits (336), Expect = 1e-30
Identities = 269/1142 (23%), Positives = 353/1142 (30%), Gaps = 305/1142 (26%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCIN 904
+D CA + C C N P GY C C GY+L C D +EC + C N
Sbjct: 373 VDDCA---DSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHHCTN 429
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYH----------- 953
GS+ C C GY L ++ + + E+P V G+ H
Sbjct: 430 LAGSFQCSCEAGYRL-----HEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDELPQL 484
Query: 954 ------------CECDQGYIMVRKGHCQD----------INECRHPGTCPDG-RCVNSPG 990
E + + K C D ++CR+ GTC G + P
Sbjct: 485 FQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPE 544
Query: 991 SYTCLACEEGYRGQS--GSCVDVNECLTPGVC--AHGKCTNLEGSFRCSCEQGYEVTSDE 1046
+T L C E + +C C G C G C G +CE G
Sbjct: 545 GWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYG 604
Query: 1047 KGCQDVDECASRASCPT--GLCLNTEG-------------SFACSACENGYWVNEDGTAC 1091
K C+ CA+R C G CL G +F E V +C
Sbjct: 605 KHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSC 664
Query: 1092 EDLD----------------ECAF----PG-----VCPSGVCTNTAGSFSCKDCDGGYRP 1126
+ D EC PG CP GV ++ K C G++
Sbjct: 665 DKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQG 724
Query: 1127 SPLGDSCEDVDECEDPQSSCL--GGECKNTVGSYQCLCPQGFQLAN----------GTVC 1174
G C + SSC G C G QC CP G + G C
Sbjct: 725 EDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCEADCPEGRWGLGC 782
Query: 1175 EDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAE---------GGTSCQDVDECATT 1225
+++ C +H A C G+ CLC PGFV + G SCQ CA
Sbjct: 783 QEI--CPACQHAA---RCDPETGA--CLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCAND 835
Query: 1226 DPC--VGGHCVNTEG--SFNC--LCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENS 1279
C GHC G F+C C+TG P+ + D + G CE
Sbjct: 836 GHCHPATGHCSCAPGWTGFSCQRACDTGHW-GPDCSHPCNCSAGHGSCDAISGLCLCEAG 894
Query: 1280 PGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRC-------LCDQ 1332
RC C G H P C C CD+ G+ C C+
Sbjct: 895 YVGPRCEQQCPQG-HFGPG--------CEQRCQCQHGAACDHVSGACTCPAGWRGTFCEH 945
Query: 1333 GFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAG 1392
G DC C GAA C+ V GS LC P G
Sbjct: 946 ACPAGFFGLDCRSACNC-----TAGAA-CDAVNGSCLC-----------------PAGRR 982
Query: 1393 GQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDA---CD 1449
G +E PA T G N +QA C C GAS C
Sbjct: 983 GPRCAET-----CPAHT-----------------YGHNCSQA-CACFNGASCDPVHGQCH 1019
Query: 1450 LCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTD--ADECVIFGPGLCPNGRCLNTVP 1507
P + CP+G +Y D C LC NG + V
Sbjct: 1020 CAPGWMGPSCLQACPAG---------------LYGDNCRHSC------LCQNGGTCDPVS 1058
Query: 1508 GYVCLCNPGFHYDASHKKCEDHDECQDLACENGECVN----TEGSFHCFCSPPLTLDLSQ 1563
G+ C C G+ A K+C D + +G C+N + C C T D Q
Sbjct: 1059 GH-CACPEGWAGLACEKECLPRD-VRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQ 1116
Query: 1564 QRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWSQQCAL 1623
C+ + C ++ + C H T C C G S
Sbjct: 1117 SPCLRGWFG-----------EACAQRCS---CPPGAACHHVT-GACRCPPGFTGSGCEQA 1161
Query: 1624 CPPRS-SEVYAQL---------CNVARIEAEREAGVHFR------PGYEYGPGPDDLHYS 1667
CPP S E AQ+ C+ A AG H P YGPG + L
Sbjct: 1162 CPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGC 1221
Query: 1668 IYGP--DGAPF-----YNYLGPED--TVPEPAF-PNT-----AGHSADRTPILESPLQPS 1712
+ G D A +LG + T P+ F PN G A P+ + L
Sbjct: 1222 LNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCL--- 1278
Query: 1713 ELQPHYVASHPEPPAGFEGLQAEE----------CGILNGCENGRCVRVREGYTCDCFEG 1762
P G G++ E C C NG G +C C G
Sbjct: 1279 ------------CPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNG-SCSCGLG 1325
Query: 1763 FQLDAAHMACVDVN-------ECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPP 1815
+ +AC EC N + CE G+ C C PG+ +A
Sbjct: 1326 WTGRHCELACPPGRYGAACHLECSCHN-------NSTCEPATGT--CRCGPGFYGQACEH 1376
Query: 1816 HC 1817
C
Sbjct: 1377 PC 1378
Score = 130 bits (328), Expect = 9e-30
Identities = 202/849 (23%), Positives = 272/849 (32%), Gaps = 163/849 (19%)
Query: 1078 CENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DV 1136
C G+ D C EC+ G C GS C G++ G C+ DV
Sbjct: 110 CCRGWMQQPDEEGCLSA-ECSASLCFHGGRCV--PGSAQPCHCPPGFQ----GPRCQYDV 162
Query: 1137 DECEDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNEC-MGEEHCAPHGECLN 1194
DEC C C NT GSY C C GF+L + C +N C +G C H C+
Sbjct: 163 DECRTHNGGCQH-RCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHH--CVQ 219
Query: 1195 -SHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPE 1253
+ C C PGF E G C CA + C G C C G+Q + +
Sbjct: 220 LTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAAD 279
Query: 1254 SGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-------------- 1299
C D+DEC G C C N+ GS++CV C G+ + +G
Sbjct: 280 GKACEDVDECA-AGLAQC-AHGCLNTQGSFKCV--CHAGYELGADGRQCYRIEMEIVNSC 335
Query: 1300 ---------------------------------DCIDIDECANDTMCGSHGFCDNTDGSF 1326
CID+D+CA+ C C N G +
Sbjct: 336 EANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCC--QQVCTNNPGGY 393
Query: 1327 RCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHC 1386
C C G+ +S G C DV+EC C C N+ GSF C C + ++ + G C
Sbjct: 394 ECGCYAGYRLSADGCGCEDVDECASSRGGC-EHHCTNLAGSFQCSCEAGYRLHEDRRG-C 451
Query: 1387 RPRGAGGQSMSE-----------APTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAE 1435
P + A D P + D + A + G +T +
Sbjct: 452 SPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEA---ELRGEHTLTEK 508
Query: 1436 CCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWT---FGQTMYTDADECVIF 1492
C S+G C L + D C G WT +T D F
Sbjct: 509 FVCLDD-SFGHDCSL--TCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCPPDT-----F 560
Query: 1493 GPGL-----CPNGRCLNTVPGYVCLCNPGFHYDASHKKCED---------HDECQDLACE 1538
G C NG ++V G C C PG S CED H +
Sbjct: 561 GKNCSFSCSCQNGGTCDSVTG-ACRCPPG----VSGTNCEDGCPKGYYGKHCRKKCNCAN 615
Query: 1539 NGECVNTEGSFHCFCSPPLTLDLSQQRC---MNSTSSTEDLPDHDIHMDICWKKVTNDVC 1595
G C G+ C C P L C +E+ H C K+ + C
Sbjct: 616 RGRCHRLYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDGSCSC 673
Query: 1596 SEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLCNVARIEAEREAGVHFRPGY 1655
RG R EC Q CP VA E G G+
Sbjct: 674 KAGFRGER-CQAECELGYFGPGCWQACTCP----------VGVACDSVSGECGKRCPAGF 722
Query: 1656 EYGPGPDDLHYSIYGPD--------GAPFYNYLGPEDTVPEPAFPNTAGHSADR-TPILE 1706
+ + +G + GAP + G + P P G + P
Sbjct: 723 QGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG-QCRCP----PGRTGEDCEADCPEGR 777
Query: 1707 SPLQPSELQP---HYVASHPEPPA-----GFEGLQAEE---CGILNGCENGRCVRVREGY 1755
L E+ P H PE A GF G + ++ G RC +G+
Sbjct: 778 WGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGH 837
Query: 1756 T------CDCFEGFQLDAAHMACVDVNECDDLNGPAVLCV-HGYCENTEGSYRCHCSPGY 1808
C C G+ + AC + D + P HG C+ G C C GY
Sbjct: 838 CHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISG--LCLCEAGY 895
Query: 1809 VAEAGPPHC 1817
V C
Sbjct: 896 VGPRCEQQC 904
Score = 122 bits (306), Expect = 3e-27
Identities = 198/782 (25%), Positives = 253/782 (32%), Gaps = 156/782 (19%)
Query: 856 CGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDN-----ECLRDPCKGKGRCINRVGSYS 910
CG C + +C C PG +A C + + + C+ RC G+
Sbjct: 746 CGGAPCHGVTG--QCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDPETGA-- 801
Query: 911 CFCYPGYTLATSGATQECQDI-------NECEQPGVCSG-GQCTNTEGSYHCECDQGYIM 962
C C PG+ CQD+ C+ C+ G C G HC C G+
Sbjct: 802 CLCLPGFV------GSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCAPGWTG 853
Query: 963 VRKGHCQDIN----ECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPG 1018
D +C HP C G S CL CE GY G PG
Sbjct: 854 FSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCL-CEAGYVGPRCEQQCPQGHFGPG 912
Query: 1019 V-----CAHGK-CTNLEGSFRCSCEQGYEVTSDEKGCQDVD---ECASRASCPTGL-CLN 1068
C HG C ++ G+ C+C G+ T E C +C S +C G C
Sbjct: 913 CEQRCQCQHGAACDHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDA 970
Query: 1069 TEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGV-CTNTAGSFSCKDCDGGYRPS 1127
GS C A G E A C+ C +G C G C G PS
Sbjct: 971 VNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHC--APGWMGPS 1028
Query: 1128 PL--------GDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNE 1179
L GD+C C++ GG C G C CP+G+ G CE E
Sbjct: 1029 CLQACPAGLYGDNCRHSCLCQN------GGTCDPVSG--HCACPEGWA---GLACE--KE 1075
Query: 1180 CMGEE---HCAPHGECLNSH----GSFFCLCAPGFVSAEGGTSCQDV-------DECATT 1225
C+ + C G CLN + CLC G+ G CQ + CA
Sbjct: 1076 CLPRDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWT----GDKCQSPCLRGWFGEACAQR 1131
Query: 1226 DPCV-GGHCVNTEGSFNCL-------CETGFQPSPESGECVDIDECEDYGD---PVCGTW 1274
C G C + G+ C CE P +C + +C P GT
Sbjct: 1132 CSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTC 1191
Query: 1275 KCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGF 1334
C C C PG + C + C N G CD G+ C C GF
Sbjct: 1192 SCAAGYHGPSCQQRCPPGRY---GPGCEQLCGCLNG------GSCDAATGA--CRCPTGF 1240
Query: 1335 EISPSGWDCVDVNECELMLAVCGA---ALCENVEGSFLCLCASDLEEYDAQEGHCRPR-G 1390
+ C VCG A C+ V G+ CLC + G + R G
Sbjct: 1241 LGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGT--CLCPPGRAGVRCERGCPQNRFG 1298
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
G + G A + CS LG E C G +G AC L
Sbjct: 1299 VGCEHTCSCRNGGLCHA-----------SNGSCSCGLGWTGRHCELACPPGR-YGAACHL 1346
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADE--CV--IFGPGL-----CPNGR 1501
E S + C P G G Y A E C G G C +G
Sbjct: 1347 ---ECSCHNNSTCE------PATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQHGA 1397
Query: 1502 CLNTVPGYVCLCNPGFHYDASHKKCED-------HDECQDLACENG-ECVNTEGSFHCFC 1553
+ + G CLC GFH + CE H C C+ G C G C C
Sbjct: 1398 PCDPISGR-CLCPAGFHGHFCERGCEPGSFGEGCHQRCD---CDGGAPCDPVTGL--CLC 1451
Query: 1554 SP 1555
P
Sbjct: 1452 PP 1453
Score = 115 bits (288), Expect = 4e-25
Identities = 169/659 (25%), Positives = 215/659 (32%), Gaps = 143/659 (21%)
Query: 847 RCAAGAT--NVCGPGTCVNLPDGYR---C--VCSPGYQLHPSQAYCTDDNECLRDPCKGK 899
+C GA +V G TC P G+R C C G+ ++ C D G
Sbjct: 918 QCQHGAACDHVSGACTC---PAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNGS 974
Query: 900 GRC-INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVC-SGGQCTNTEGSYHC--- 954
C R G P +T + C Q C +G C G HC
Sbjct: 975 CLCPAGRRGPRCAETCPAHTYG-----------HNCSQACACFNGASCDPVHGQCHCAPG 1023
Query: 955 ----ECDQGYIMVRKG-HCQDINECRHPGTCP--DGRCVNSPGSYTCLACEEGY--RGQS 1005
C Q G +C+ C++ GTC G C P + LACE+ R
Sbjct: 1024 WMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCA-CPEGWAGLACEKECLPRDVR 1082
Query: 1006 GSCVDVNECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDV---DECASRASCP 1062
C CL G+C + RC C G+ + C + CA R SCP
Sbjct: 1083 AGCRHSGGCLNGGLCD-------PHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCP 1135
Query: 1063 TGL-CLNTEGSFAC------SACENGYWVNEDGTACEDLDECAFPGVCPS-----GVCTN 1110
G C + G+ C S CE G C + +C PG P+ G C+
Sbjct: 1136 PGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQC--PGENPACHPATGTCSC 1193
Query: 1111 TAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGF---- 1166
AG + C P G CE + C + GG C G+ C CP GF
Sbjct: 1194 AAG-YHGPSCQQRCPPGRYGPGCEQLCGCLN------GGSCDAATGA--CRCPTGFLGTD 1244
Query: 1167 ------QLANGTVCEDVNECMGEEHCAP-HGECLNSHGSFFCLCAPGFVSAEGGTSCQDV 1219
Q G C V C C P G CL G C G G C+
Sbjct: 1245 CNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHT 1304
Query: 1220 DECATTDPCVGGHCVNTEGSFNC-------LCETGFQPSPESGECVDIDECEDYG--DPV 1270
C GG C + GS +C CE P C C + +P
Sbjct: 1305 CSCRN-----GGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPA 1359
Query: 1271 CGTWKCENSPGSY--RCVLGCQPGFHMAPNGDCIDIDECANDTMCGS-HGFCDNTDGSFR 1327
GT +C PG Y C C PGFH A C + C + C G C G
Sbjct: 1360 TGTCRC--GPGFYGQACEHPCPPGFHGA---GCQGLCWCQHGAPCDPISGRCLCPAGFHG 1414
Query: 1328 CLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR 1387
C++G E G C +C+ G A C+ V G LCLC
Sbjct: 1415 HFCERGCEPGSFGEGCHQRCDCD------GGAPCDPVTG--LCLC--------------- 1451
Query: 1388 PRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG-----HAPCSSVLGRNTTQAECCCTQG 1441
P G G A +DC GQ G H C + +C C G
Sbjct: 1452 PPGRSG-------------ATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDG 1497
Score = 59.3 bits (142), Expect = 3e-08
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 7/99 (7%)
Query: 1726 PAGFEG----LQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL 1781
P GF+G +EC NG RCV Y C+C GF+L C+ +N C
Sbjct: 150 PPGFQGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALG 209
Query: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGPPHCTAK 1820
NG C H + T +RC C PG+ + HC +
Sbjct: 210 NGG---CQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRR 245
Score = 51.6 bits (122), Expect = 7e-06
Identities = 35/106 (33%), Positives = 47/106 (44%), Gaps = 13/106 (12%)
Query: 573 QEDCCGSVGAFWGVTLC---APCPPRPASPVIENGQLECPQGYKRLNLTHCQ-DINECLT 628
Q D G + A +LC C P A P CP G++ CQ D++EC T
Sbjct: 117 QPDEEGCLSAECSASLCFHGGRCVPGSAQPC------HCPPGFQG---PRCQYDVDECRT 167
Query: 629 LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLC 674
CVNT GSYLC C+PG L C++ + ++ G C
Sbjct: 168 HNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGC 213
Score = 47.0 bits (110), Expect = 2e-04
Identities = 77/310 (24%), Positives = 99/310 (31%), Gaps = 90/310 (29%)
Query: 173 CCPGWTTANSTNHCIK----PVCEPPCQ---NRGSCSRPQ-LCVCRSGFRGARCEEVIPD 224
C PGWT + C P C PC GSC LC+C +G+ G RCE+ P
Sbjct: 847 CAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQ 906
Query: 225 EEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGTLSGLSQ 284
F P E+ + +A + A P + + PAG
Sbjct: 907 GHFGP---------GCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAG------- 950
Query: 285 THPSQQHVGLSRTVRLHPTA-TASSQLSSNALPPGPGLEQRDGTQQAVPLEHPSSPWGLN 343
GL + TA A ++ + L P R G + A P+ +G N
Sbjct: 951 ------FFGLDCRSACNCTAGAACDAVNGSCLCPA----GRRGPRCAETC--PAHTYGHN 998
Query: 344 LTEKIKKIKIVFTPTICKQTCARGHCA-----NSCERGDTTTLYS---------QGGHGH 389
++ F C + HCA SC + LY Q G
Sbjct: 999 CSQAC----ACFNGASCDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTC 1054
Query: 390 DPKSGFRIYFCQIP--------------------------CLNGGRC---IGRDECWCPA 420
DP SG C P CLNGG C GR C CPA
Sbjct: 1055 DPVSG----HCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGR--CLCPA 1108
Query: 421 NSTGKFCHLP 430
TG C P
Sbjct: 1109 GWTGDKCQSP 1118
Score = 40.8 bits (94), Expect = 0.012
Identities = 44/174 (25%), Positives = 67/174 (38%), Gaps = 26/174 (14%)
Query: 560 NGQCANPLLELTTQEDCCGSVGAFW------GVTLCAPCPPRPAS-----PVIEN-GQLE 607
NG C + ++LT C F +PC R S V+ + E
Sbjct: 210 NGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCE 269
Query: 608 CPQGYK-RLNLTHCQDINECLTLGLCKDAE-CVNTRGSYLCTCRPGLMLDPSRSRC--VS 663
C GY+ + C+D++EC GL + A C+NT+GS+ C C G L +C +
Sbjct: 270 CHVGYQLAADGKACEDVDECAA-GLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIE 328
Query: 664 DKAISMLQ--------GLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSEC 709
+ ++ + G + S GP CT P + C V S C
Sbjct: 329 MEIVNSCEANNGGCSHGCSHTSAGP-LCTCPRGYELDTDQRTCIDVDDCADSPC 381
Score = 39.7 bits (91), Expect = 0.027
Identities = 86/339 (25%), Positives = 107/339 (31%), Gaps = 89/339 (26%)
Query: 173 CCPGWTTANSTNHCIKPV----CEPP--CQNRGSCSRPQ-LCVCRSGFRGARCE-EVIPD 224
C PGW + C + C CQN G+C C C G+ G CE E +P
Sbjct: 1020 CAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPR 1079
Query: 225 EE---------------FDPQNSR-LAPRRWAE---RSPNLRRSSAAGEGTLARAQPPAP 265
+ DP R L P W +SP LR GE R P
Sbjct: 1080 DVRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLR--GWFGEACAQRCSCPPG 1137
Query: 266 QS----PPAPQSPPAGTLSGLSQTHP--------SQQHVGLSRTVRLHP-TATASSQLS- 311
+ A + PP T SG Q P +Q HP T T S
Sbjct: 1138 AACHHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGY 1197
Query: 312 -----SNALPP---GPGLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQT 363
PP GPG EQ G + + + F T C T
Sbjct: 1198 HGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGAC---------RCPTGFLGTDCNLT 1248
Query: 364 CARG----HCANSCERGD--------TTTLYSQGGHG-----HDPKSGFRI---YFCQIP 403
C +G +C + C G T L G G P++ F + + C
Sbjct: 1249 CPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCS-- 1306
Query: 404 CLNGGRC-IGRDECWCPANSTGKFCHLPIPQPDREPPGR 441
C NGG C C C TG+ C L PPGR
Sbjct: 1307 CRNGGLCHASNGSCSCGLGWTGRHCELAC------PPGR 1339
Score = 35.8 bits (81), Expect = 0.39
Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 3/51 (5%)
Query: 172 QCCPGWTTANSTNHCIKPVCEPP-CQNRGSC--SRPQLCVCRSGFRGARCE 219
+CC GW C+ C C + G C Q C C GF+G RC+
Sbjct: 109 RCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQ 159
Score = 35.4 bits (80), Expect = 0.51
Identities = 26/97 (26%), Positives = 37/97 (38%), Gaps = 6/97 (6%)
Query: 608 CPQGYKR-LNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVS-DK 665
CP+GY+ + C D+++C C+ C N G Y C C G L C D+
Sbjct: 357 CPRGYELDTDQRTCIDVDDCADSPCCQQV-CTNNPGGYECGCYAGYRLSADGCGCEDVDE 415
Query: 666 AISMLQGL---CYRSLGPGTCTLPLAQRITKQICCCS 699
S G C G C+ R+ + CS
Sbjct: 416 CASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCS 452
Score = 34.7 bits (78), Expect = 0.87
Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 10/67 (14%)
Query: 172 QCCPGWTTANSTNHC--------IKPVCEPPCQNRGSCS-RPQLCVCRSGFRGARCEEVI 222
+C PG T + C + +C P CQ+ C C+C GF G+RC++V
Sbjct: 759 RCPPGRTGEDCEADCPEGRWGLGCQEIC-PACQHAARCDPETGACLCLPGFVGSRCQDVC 817
Query: 223 PDEEFDP 229
P + P
Sbjct: 818 PAGWYGP 824
Score = 32.7 bits (73), Expect = 3.3
Identities = 16/49 (32%), Positives = 24/49 (48%), Gaps = 9/49 (18%)
Query: 174 CPGWTTANSTNH---CIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCE 219
CP W + C++P + + GSCS C++GFRG RC+
Sbjct: 641 CPPWAFGPGCSEECQCVQPHTQSCDKRDGSCS------CKAGFRGERCQ 683
Score = 32.0 bits (71), Expect = 5.6
Identities = 22/62 (35%), Positives = 29/62 (46%), Gaps = 15/62 (24%)
Query: 172 QCCPGWTTANSTNHCIKPVCEPPCQNR-GSC-SRPQL------CVCRSGFR----GARCE 219
QC PG+ HC++ PC NR GSC R Q+ C C G++ G CE
Sbjct: 228 QCRPGFQLQEDGRHCVR---RSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE 284
Query: 220 EV 221
+V
Sbjct: 285 DV 286
Score = 31.6 bits (70), Expect = 7.4
Identities = 16/33 (48%), Positives = 18/33 (54%), Gaps = 2/33 (6%)
Query: 404 CLNGGRCI-GRDECWCPANSTGKFCHLPIPQPD 435
C NGG C+ G D C CP TG C+ P PD
Sbjct: 527 CRNGGTCLLGLDGCDCPEGWTGLICNETCP-PD 558
Score = 31.6 bits (70), Expect = 7.4
Identities = 22/63 (34%), Positives = 23/63 (36%), Gaps = 4/63 (6%)
Query: 168 VCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQ-LCVCRSGFRGARCEEVIPDEE 226
V G C G HC K C C NRG C R C+C G G C P
Sbjct: 589 VSGTNCEDGCPKGYYGKHCRKK-CN--CANRGRCHRLYGACLCDPGLYGRFCHLTCPPWA 645
Query: 227 FDP 229
F P
Sbjct: 646 FGP 648
Score = 31.2 bits (69), Expect = 9.6
Identities = 20/85 (23%), Positives = 33/85 (38%), Gaps = 12/85 (14%)
Query: 153 AAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHC--------IKPVCEPPCQNRGSCSRP 204
+ PP +TG C +C PG+T + C +C+ P +N
Sbjct: 1133 SCPPGAACHHVTG--AC--RCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPAT 1188
Query: 205 QLCVCRSGFRGARCEEVIPDEEFDP 229
C C +G+ G C++ P + P
Sbjct: 1189 GTCSCAAGYHGPSCQQRCPPGRYGP 1213
Score = 31.2 bits (69), Expect = 9.6
Identities = 35/133 (26%), Positives = 43/133 (32%), Gaps = 18/133 (13%)
Query: 606 LECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
L CPQG N TH G + A C G+ C C PG C ++
Sbjct: 1247 LTCPQGRFGPNCTH--------VCGCGQGAACDPVTGT--CLCPPGRAGVRCERGCPQNR 1296
Query: 666 --------AISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGT 717
GLC+ S G +C L R + C R G A EC
Sbjct: 1297 FGVGCEHTCSCRNGGLCHASNGSCSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTC 1356
Query: 718 EAFREICPAGHGY 730
E C G G+
Sbjct: 1357 EPATGTCRCGPGF 1369
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 196 bits (499), Expect = 1e-49
Identities = 159/555 (28%), Positives = 237/555 (42%), Gaps = 83/555 (14%)
Query: 850 AGATNVCGPG-TCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVGS 908
A +N C G +C +P G+ C C G+ D +EC +PC G C+++V
Sbjct: 350 ACTSNPCANGGSCHEVPSGFECHCPSGWS---GPTCALDIDECASNPCAAGGTCVDQVDG 406
Query: 909 YSCFCYPGYTLATSGATQECQ-DINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG- 966
+ C C + AT CQ D NECE + C N G Y+C+C G+ KG
Sbjct: 407 FECICPEQWVGAT------CQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGW----KGI 456
Query: 967 HCQ-DINECR----HPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCA 1021
+C ++N+CR H GTC D VN Y C+ C G+ G+ ++ +EC + +
Sbjct: 457 NCHINVNDCRGQCQHGGTCKD--LVN---GYQCV-CPRGFGGRHCE-LERDECASSPCHS 509
Query: 1022 HGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENG 1081
G C +L F C C QG+ E DVD C C N EG + C AC +
Sbjct: 510 GGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCEPSPCRNGARCYNLEGDYYC-ACPDD 565
Query: 1082 YWVNE--------DGTACEDLDEC------AFPGVCPSGVC-------TNTAGSFSCKDC 1120
+ G AC +D C PG SGVC + G+FSC C
Sbjct: 566 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC-IC 624
Query: 1121 DGGYRPSPLGDSC-EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-DVN 1178
D G+ G C E++D+C Q GG C + V +++C CP G++ G +C+ + N
Sbjct: 625 DSGF----TGTYCHENIDDCLG-QPCRNGGTCIDEVDAFRCFCPSGWE---GELCDTNPN 676
Query: 1179 ECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEG 1238
+C+ + C G C + F+C C G+ +G T +C GG C ++
Sbjct: 677 DCL-PDPCHSRGRCYDLVNDFYCACDDGW---KGKTCHSREFQCDAYTCSNGGTCYDSGD 732
Query: 1239 SFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN 1298
+F C C G++ S C +P C S S+ C+ C+ G+
Sbjct: 733 TFRCACPPGWKGS----TCAVAKNSSCLPNPCVNGGTCVGSGASFSCI--CRDGWE---G 783
Query: 1299 GDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCG 1357
C N C + G C + FRC C GF +G DC ++++EC+ G
Sbjct: 784 RTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF----AGPDCRINIDECQSSPCAYG 839
Query: 1358 AALCENVEGSFLCLC 1372
A + + G + C C
Sbjct: 840 ATCVDEING-YRCSC 853
Score = 192 bits (489), Expect = 2e-48
Identities = 207/768 (26%), Positives = 297/768 (38%), Gaps = 139/768 (18%)
Query: 854 NVCGP-------GTCVNL-PDGYRCVCSPGYQLHPSQAYCTD-DNECLRDPCKGKGRCIN 904
N CG GTC+N PD YRC C GY S C ++ C +PC G C
Sbjct: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHE 364
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
+ C C G++ T DI+EC +GG C + + C C + ++
Sbjct: 365 VPSGFECHCPSGWSGPTCAL-----DIDECASNPCAAGGTCVDQVDGFECICPEQWV--- 416
Query: 965 KGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAH- 1022
CQ D NEC C N G Y C C G++G ++VN+C G C H
Sbjct: 417 GATCQLDANECEGKPCLNAFSCKNLIGGYYC-DCIPGWKG-INCHINVNDC--RGQCQHG 472
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQ-DVDECASRASCPTGLCLNTEGSFACSACENG 1081
G C +L ++C C +G+ + C+ + DECAS GLC + F C C G
Sbjct: 473 GTCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG 527
Query: 1082 YWVNEDGTACE-DLDECAFPGVCPSGV-CTNTAGSFSC--------KDCDGGYRPSPLGD 1131
+ G CE D+D C P C +G C N G + C K+C P P G
Sbjct: 528 F----SGPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP-GG 581
Query: 1132 SCEDVDECEDPQSSCLGGECKNTV------------GSYQCLCPQGFQLANGTVC-EDVN 1178
+C +D C + G + V G++ C+C GF GT C E+++
Sbjct: 582 ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF---TGTYCHENID 638
Query: 1179 ECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG-GHCVNTE 1237
+C+G+ C G C++ +F C C G+ EG + ++C DPC G C +
Sbjct: 639 DCLGQP-CRNGGTCIDEVDAFRCFCPSGW---EGELCDTNPNDC-LPDPCHSRGRCYDLV 693
Query: 1238 GSFNCLCETGFQ-PSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFH-- 1294
F C C+ G++ + S E +C+ Y GT C +S ++RC C PG+
Sbjct: 694 NDFYCACDDGWKGKTCHSREF----QCDAYTCSNGGT--CYDSGDTFRC--ACPPGWKGS 745
Query: 1295 ---MAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCV-DVNECE 1350
+A N C+ C + G C + SF C+C G+E G C + N+C
Sbjct: 746 TCAVAKNSSCL-------PNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCN 794
Query: 1351 LMLAVCGAALCENVEGSFLCLCASDLEEYDAQ----EGHCRPRGAGGQSMSEAPTGDHAP 1406
L +C + F C CA D + E P G + E
Sbjct: 795 -PLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEI------- 846
Query: 1407 APTRMDCYSGQKGHAPCSSVL--GRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICP 1464
R C G+ G C V+ GR+ G+SW + C+ C D
Sbjct: 847 NGYRCSCPPGRAG-PRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRR-----D 900
Query: 1465 SGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDASH 1523
K + + GQ A CP G RCL PG CL P
Sbjct: 901 CSKVWCGWKPCLLAGQPEALSAQ---------CPLGQRCLEKAPGQ-CLRPP-------- 942
Query: 1524 KKCEDHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMNSTS 1571
CE EC + C+ G C+ LTL ++ T+
Sbjct: 943 --CEAWGECGAEEPPSTPCLPRSGHLDNNCA-RLTLHFNRDHVPQGTT 987
Score = 144 bits (363), Expect = 8e-34
Identities = 162/613 (26%), Positives = 214/613 (34%), Gaps = 137/613 (22%)
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGY 1082
G +LE R C++ Y + K C+ ++ +C + AC +G+
Sbjct: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCD---------QYGNKACMDGW 235
Query: 1083 WVNEDGTA-----CEDLDE-CAFPGVCPSGVCTNTAGSFSC---KDCDGGYRPSPLGDSC 1133
E A C L C PG C C C G P +C
Sbjct: 236 MGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNC 295
Query: 1134 E----------DVDECEDPQSSCLGGECKNTV-GSYQCLCPQGFQLANGTVCEDVNECMG 1182
E D++ C GG C N Y+C CP G+ +G CE
Sbjct: 296 ETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---SGRNCEKAEHACT 352
Query: 1183 EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNC 1242
CA G C F C C G+ G T D+DECA+ GG CV+ F C
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGW---SGPTCALDIDECASNPCAAGGTCVDQVDGFEC 409
Query: 1243 LCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGF-----HMAP 1297
+C P G +D E G P + C+N G Y C C PG+ H+
Sbjct: 410 IC-----PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYC--DCIPGWKGINCHINV 462
Query: 1298 N---------GDCIDI---------------------DECANDTMCGSHGFCDNTDGSFR 1327
N G C D+ DECA+ + C S G C++ F
Sbjct: 463 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-SPCHSGGLCEDLADGFH 521
Query: 1328 CLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCASD-------LEEY 1379
C C QGF SG C VDV+ CE GA C N+EG + C C D +
Sbjct: 522 CHCPQGF----SGPLCEVDVDLCEPSPCRNGAR-CYNLEGDYYCACPDDFGGKNCSVPRE 576
Query: 1380 DAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKG-HAPCSSVLGRNTTQAECCC 1438
G CR G G A SG G H C S G N + C C
Sbjct: 577 PCPGGACRVIDGCGSDAGPGMPGTAA---------SGVCGPHGRCVSQPGGNFS---CIC 624
Query: 1439 TQGAS-----------WGDAC---DLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYT 1484
G + G C C E A F CPSG W G+ T
Sbjct: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDA-FRCFCPSG---------WE-GELCDT 673
Query: 1485 DADECVIFGPGLC-PNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN-GEC 1542
+ ++C+ P C GRC + V + C C+ G+ H + +C C N G C
Sbjct: 674 NPNDCL---PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR---EFQCDAYTCSNGGTC 727
Query: 1543 VNTEGSFHCFCSP 1555
++ +F C C P
Sbjct: 728 YDSGDTFRCACPP 740
Score = 110 bits (275), Expect = 1e-23
Identities = 113/412 (27%), Positives = 163/412 (39%), Gaps = 85/412 (20%)
Query: 843 PGIDRCAAGATNVCGP-GTCVNLPDG-YRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGK 899
PG+ AA + VCGP G CV+ P G + C+C G+ + YC ++ ++CL PC+
Sbjct: 595 PGMPGTAA--SGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLGQPCRNG 648
Query: 900 GRCINRVGSYSCFCYPGYTLATSGATQECQ-DINECEQPGVCSGGQCTNTEGSYHCECDQ 958
G CI+ V ++ CFC G+ + C + N+C S G+C + ++C CD
Sbjct: 649 GTCIDEVDAFRCFCPSGW------EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDD 702
Query: 959 GY----IMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC 1014
G+ R+ C D C + GTC D S ++ C AC G++G + + + C
Sbjct: 703 GWKGKTCHSREFQC-DAYTCSNGGTCYD-----SGDTFRC-ACPPGWKGSTCAVAKNSSC 755
Query: 1015 LTPGVCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSF 1073
L P C + G C SF C C G+E + ++C G+C++ F
Sbjct: 756 L-PNPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
Query: 1074 ACSACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSC--------------- 1117
C C G+ G C ++DEC C + + C
Sbjct: 812 RCE-CAPGF----AGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
Query: 1118 ---KDCDGGYRPSPLGDS-CEDVDECEDPQSSCLGG--EC-KNTVGSYQCL--------- 1161
+ C P P G S ED + C CL G +C K G CL
Sbjct: 867 GFGRSCWSRGTPFPHGSSWVEDCNSCR-----CLDGRRDCSKVWCGWKPCLLAGQPEALS 921
Query: 1162 --CPQG---FQLANGTV----CEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204
CP G + A G CE EC EE P CL G CA
Sbjct: 922 AQCPLGQRCLEKAPGQCLRPPCEAWGECGAEE--PPSTPCLPRSGHLDNNCA 971
Score = 66.2 bits (160), Expect = 3e-10
Identities = 143/677 (21%), Positives = 210/677 (31%), Gaps = 185/677 (27%)
Query: 1147 LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPG 1206
+G ECK V C QG L +G C GEC S+G C
Sbjct: 236 MGKECKEAV------CKQGCNLLHGG-------------CTVPGECRCSYGWQGRFC--- 273
Query: 1207 FVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDY 1266
DEC CV G CV + C CET ++
Sbjct: 274 -------------DECVPYPGCVHGSCVEP---WQCNCET------------------NW 299
Query: 1267 GDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTD-GS 1325
G +C D++ C + C + G C N +
Sbjct: 300 GGLLCDK-----------------------------DLNYCGSHHPCTNGGTCINAEPDQ 330
Query: 1326 FRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLE----EYDA 1381
+RC C G+ SG +C C V F C C S D
Sbjct: 331 YRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
Query: 1382 QEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQG 1441
E P AGG + + G P + + G + G+ A C +
Sbjct: 387 DECASNPCAAGGTCVDQVD-GFECICPEQ---WVGATCQLDANECEGKPCLNAFSC--KN 440
Query: 1442 ASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNG- 1500
G CD P W G + + ++C G C +G
Sbjct: 441 LIGGYYCDCIPG----------------------WK-GINCHINVNDC----RGQCQHGG 473
Query: 1501 RCLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACENGE-CVNTEGSFHCFCSPPLT 1558
C + V GY C+C GF + CE + DEC C +G C + FHC C +
Sbjct: 474 TCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFS 529
Query: 1559 LDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEAWS 1618
L + + +D+C P R Y +G+ +
Sbjct: 530 GPLCE-----------------VDVDLCEPS--------PCRNGARCYN----LEGDYY- 559
Query: 1619 QQCALCPPRSSEVYAQLCNVARIEAEREA-GVHFRPGYEYGPG-PDDLHYSIYGPDGAPF 1676
CA CP + + C+V R A V G + GPG P + GP G
Sbjct: 560 --CA-CP---DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCV 613
Query: 1677 YNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEG----L 1732
G + + F T H + + A P+G+EG
Sbjct: 614 SQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDT 673
Query: 1733 QAEECGILNGCEN-GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHG 1791
+C + + C + GRC + + C C +G++ H + NG G
Sbjct: 674 NPNDC-LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG-------G 725
Query: 1792 YCENTEGSYRCHCSPGY 1808
C ++ ++RC C PG+
Sbjct: 726 TCYDSGDTFRCACPPGW 742
Score = 40.4 bits (93), Expect = 0.016
Identities = 33/92 (35%), Positives = 40/92 (43%), Gaps = 19/92 (20%)
Query: 366 RGHCANS-CERGDTTTLYSQGGHGHDPKSGFRIYFCQI--------PCLNGGRCI---GR 413
R CA+S C G + G H H P+ GF C++ PC NG RC G
Sbjct: 499 RDECASSPCHSGGLCEDLADGFHCHCPQ-GFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 557
Query: 414 DECWCPANSTGKFCHLPIPQPDREP-PGRGSR 444
C CP + GK C +P REP PG R
Sbjct: 558 YYCACPDDFGGKNCSVP-----REPCPGGACR 584
Score = 38.5 bits (88), Expect = 0.060
Identities = 26/98 (26%), Positives = 40/98 (40%), Gaps = 22/98 (22%)
Query: 363 TCARGHCANSCERGD---TTTLYSQGGHGHDPKSGFRIYF--------CQI--------P 403
TC G+ +CE+ + T+ + GG H+ SGF + C + P
Sbjct: 334 TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP 393
Query: 404 CLNGGRCIGRD---ECWCPANSTGKFCHLPIPQPDREP 438
C GG C+ + EC CP G C L + + +P
Sbjct: 394 CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKP 431
Score = 38.1 bits (87), Expect = 0.079
Identities = 22/60 (36%), Positives = 26/60 (43%), Gaps = 8/60 (13%)
Query: 166 RNVCGG---QCCPGWTTANSTNHCIKPVCEPPCQNRGSCS---RPQLCVCRSGFRGARCE 219
+N+ GG C PGW N H C CQ+ G+C CVC GF G CE
Sbjct: 439 KNLIGGYYCDCIPGWKGINC--HINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/70 (30%), Positives = 28/70 (40%), Gaps = 9/70 (12%)
Query: 159 PRGRLTGRNVC----GGQCCPGWTTANSTNHCIKPVCEPPCQN-RGSCSRPQLCVCRSGF 213
PR G C C GW C + VC+ C G C+ P C C G+
Sbjct: 213 PRNDFFGHYTCDQYGNKACMDGWMG----KECKEAVCKQGCNLLHGGCTVPGECRCSYGW 268
Query: 214 RGARCEEVIP 223
+G C+E +P
Sbjct: 269 QGRFCDECVP 278
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/92 (30%), Positives = 39/92 (42%), Gaps = 16/92 (17%)
Query: 1728 GFEGL----QAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNG 1783
G+EG +C L G CV + C+C GF A ++++EC +
Sbjct: 780 GWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF---AGPDCRINIDECQ--SS 834
Query: 1784 PAVLCVHGY-CENTEGSYRCHCSPGYVAEAGP 1814
P C +G C + YRC C PG AGP
Sbjct: 835 P---CAYGATCVDEINGYRCSCPPG---RAGP 860
Score = 34.7 bits (78), Expect = 0.87
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 17/78 (21%)
Query: 1741 NGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL---NGPAVLCVHGYCENT 1796
N C NG CV ++C C +G++ + N+C+ L NG G C +
Sbjct: 758 NPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLPCYNG-------GICVDG 807
Query: 1797 EGSYRCHCSPGYVAEAGP 1814
+RC C+PG+ AGP
Sbjct: 808 VNWFRCECAPGF---AGP 822
Score = 32.3 bits (72), Expect = 4.3
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 9/52 (17%)
Query: 173 CCPGW---TTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGARC 218
C PGW T A + N P PC N G+C C+CR G+ G C
Sbjct: 738 CPPGWKGSTCAVAKNSSCLP---NPCVNGGTCVGSGASFSCICRDGWEGRTC 786
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 191 bits (486), Expect = 4e-48
Identities = 158/557 (28%), Positives = 232/557 (41%), Gaps = 88/557 (15%)
Query: 854 NVCGP-------GTCVNL-PDGYRCVCSPGYQLHPSQAYCTD-DNECLRDPCKGKGRCIN 904
N CG GTC+N PD YRC C GY S C ++ C +PC G C
Sbjct: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHE 364
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
+ C C G++ T DI+EC +GG C + + C C + ++
Sbjct: 365 VPSGFECHCPSGWSGPTCAL-----DIDECASNPCAAGGTCVDQVDGFECICPEQWV--- 416
Query: 965 KGHCQ-DINECR----HPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGV 1019
CQ D+N+CR H GTC D VN Y C+ C G+ G+ ++ +EC +
Sbjct: 417 GATCQLDVNDCRGQCQHGGTCKD--LVN---GYQCV-CPRGFGGRHCE-LERDECASSPC 469
Query: 1020 CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACE 1079
+ G C +L F C C QG+ E DVD C C N EG + C AC
Sbjct: 470 HSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCEPSPCRNGARCYNLEGDYYC-ACP 525
Query: 1080 NGYWVNE--------DGTACEDLDEC------AFPGVCPSGVC-------TNTAGSFSCK 1118
+ + G AC +D C PG SGVC + G+FSC
Sbjct: 526 DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC- 584
Query: 1119 DCDGGYRPSPLGDSC-EDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCE-D 1176
CD G+ G C E++D+C Q GG C + V +++C CP G++ G +C+ +
Sbjct: 585 ICDSGF----TGTYCHENIDDCLG-QPCRNGGTCIDEVDAFRCFCPSGWE---GELCDTN 636
Query: 1177 VNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNT 1236
N+C+ + C G C + F+C C G+ +G T +C GG C ++
Sbjct: 637 PNDCL-PDPCHSRGRCYDLVNDFYCACDDGW---KGKTCHSREFQCDAYTCSNGGTCYDS 692
Query: 1237 EGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA 1296
+F C C G++ S C +P C S S+ C+ C+ G+
Sbjct: 693 GDTFRCACPPGWKGS----TCAVAKNSSCLPNPCVNGGTCVGSGASFSCI--CRDGWE-- 744
Query: 1297 PNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAV 1355
C N C + G C + FRC C GF +G DC ++++EC+
Sbjct: 745 -GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF----AGPDCRINIDECQSSPCA 799
Query: 1356 CGAALCENVEGSFLCLC 1372
GA + + G + C C
Sbjct: 800 YGATCVDEING-YRCSC 815
Score = 158 bits (400), Expect = 4e-38
Identities = 178/657 (27%), Positives = 245/657 (37%), Gaps = 104/657 (15%)
Query: 907 GSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKG 966
G Y+C Y +EC++ C+Q G CT C C G+
Sbjct: 219 GHYTCDQYGNKACMDGWMGKECKEA-VCKQGCNLLHGGCTVPG---ECRCSYGWQGRFCD 274
Query: 967 HCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG-KC 1025
C C H G+C + N ++ L C++ D+N C + C +G C
Sbjct: 275 ECVPYPGCVH-GSCVEPWQCNCETNWGGLLCDK----------DLNYCGSHHPCTNGGTC 323
Query: 1026 TNLE-GSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWV 1084
N E +RC+C GY + EK C S G C F C C +G+
Sbjct: 324 INAEPDQYRCTCPDGYSGRNCEKA---EHACTSNPCANGGSCHEVPSGFECH-CPSGW-- 377
Query: 1085 NEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDP 1142
G C D+DECA G C + F C C + +G +C+ DV++C
Sbjct: 378 --SGPTCALDIDECASNPCAAGGTCVDQVDGFECI-CPEQW----VGATCQLDVNDC--- 427
Query: 1143 QSSCL-GGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFC 1201
+ C GG CK+ V YQC+CP+GF G CE + C G C + F C
Sbjct: 428 RGQCQHGGTCKDLVNGYQCVCPRGF---GGRHCELERDECASSPCHSGGLCEDLADGFHC 484
Query: 1202 LCAPGFVSAEGGTSCQ-DVDECATTDPCVGGHCVNTEGSFNCLCETGF---------QPS 1251
C GF G C+ DVD C + G C N EG + C C F +P
Sbjct: 485 HCPQGF----SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 540
Query: 1252 PESGECVDIDECEDYGDP---------VCGTW-KCENSPG-SYRCVLGCQPGFHMAPNGD 1300
P G C ID C P VCG +C + PG ++ C+ C GF +
Sbjct: 541 P-GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCI--CDSGFTGTYCHE 597
Query: 1301 CIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWD--CVDVNECELMLAVCGA 1358
+ID+C C + G C + +FRC C PSGW+ D N + + C +
Sbjct: 598 --NIDDCLGQP-CRNGGTCIDEVDAFRCFC-------PSGWEGELCDTNPNDCLPDPCHS 647
Query: 1359 -ALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ 1417
C ++ F C C + + + H R + S T + R C G
Sbjct: 648 RGRCYDLVNDFYCACD---DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGW 704
Query: 1418 KGH----APCSSVLGRNTTQAECCCTQGASWGDAC-DLCPSEDSAEFSEIC---PSGKGY 1469
KG A SS L C GAS+ C D + C P G
Sbjct: 705 KGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 764
Query: 1470 IPVEGAWTF---------GQTMYTDADECVIFGPGLCPNGR-CLNTVPGYVCLCNPG 1516
I V+G F G + DEC C G C++ + GY C C PG
Sbjct: 765 ICVDGVNWFRCECAPGFAGPDCRINIDECQ---SSPCAYGATCVDEINGYRCSCPPG 818
Score = 139 bits (350), Expect = 3e-32
Identities = 156/579 (26%), Positives = 209/579 (36%), Gaps = 107/579 (18%)
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGY 1082
G +LE R C++ Y + K C+ ++ +C + AC +G+
Sbjct: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCD---------QYGNKACMDGW 235
Query: 1083 WVNEDGTA-----CEDLDE-CAFPGVCPSGVCTNTAGSFSC---KDCDGGYRPSPLGDSC 1133
E A C L C PG C C C G P +C
Sbjct: 236 MGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNC 295
Query: 1134 E----------DVDECEDPQSSCLGGECKNTV-GSYQCLCPQGFQLANGTVCEDVNECMG 1182
E D++ C GG C N Y+C CP G+ +G CE
Sbjct: 296 ETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---SGRNCEKAEHACT 352
Query: 1183 EEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNC 1242
CA G C F C C G+ G T D+DECA+ GG CV+ F C
Sbjct: 353 SNPCANGGSCHEVPSGFECHCPSGW---SGPTCALDIDECASNPCAAGGTCVDQVDGFEC 409
Query: 1243 LCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDC- 1301
+C P G +D + G G C++ Y+CV C GF C
Sbjct: 410 IC-----PEQWVGATCQLDVNDCRGQCQHG-GTCKDLVNGYQCV--CPRGF---GGRHCE 458
Query: 1302 IDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAAL 1360
++ DECA+ + C S G C++ F C C QGF SG C VDV+ CE GA
Sbjct: 459 LERDECAS-SPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCEPSPCRNGAR- 512
Query: 1361 CENVEGSFLCLCASD-------LEEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDC 1413
C N+EG + C C D + G CR G G A
Sbjct: 513 CYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA-------- 564
Query: 1414 YSGQKG-HAPCSSVLGRNTTQAECCCTQGAS-----------WGDAC---DLCPSEDSAE 1458
SG G H C S G N + C C G + G C C E A
Sbjct: 565 -SGVCGPHGRCVSQPGGNFS---CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDA- 619
Query: 1459 FSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLC-PNGRCLNTVPGYVCLCNPGF 1517
F CPSG W G+ T+ ++C+ P C GRC + V + C C+ G+
Sbjct: 620 FRCFCPSG---------WE-GELCDTNPNDCL---PDPCHSRGRCYDLVNDFYCACDDGW 666
Query: 1518 HYDASHKKCEDHDECQDLACEN-GECVNTEGSFHCFCSP 1555
H + +C C N G C ++ +F C C P
Sbjct: 667 KGKTCHSR---EFQCDAYTCSNGGTCYDSGDTFRCACPP 702
Score = 110 bits (275), Expect = 1e-23
Identities = 113/412 (27%), Positives = 163/412 (39%), Gaps = 85/412 (20%)
Query: 843 PGIDRCAAGATNVCGP-GTCVNLPDG-YRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGK 899
PG+ AA + VCGP G CV+ P G + C+C G+ + YC ++ ++CL PC+
Sbjct: 557 PGMPGTAA--SGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLGQPCRNG 610
Query: 900 GRCINRVGSYSCFCYPGYTLATSGATQECQ-DINECEQPGVCSGGQCTNTEGSYHCECDQ 958
G CI+ V ++ CFC G+ + C + N+C S G+C + ++C CD
Sbjct: 611 GTCIDEVDAFRCFCPSGW------EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDD 664
Query: 959 GY----IMVRKGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNEC 1014
G+ R+ C D C + GTC D S ++ C AC G++G + + + C
Sbjct: 665 GWKGKTCHSREFQC-DAYTCSNGGTCYD-----SGDTFRC-ACPPGWKGSTCAVAKNSSC 717
Query: 1015 LTPGVCAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSF 1073
L P C + G C SF C C G+E + ++C G+C++ F
Sbjct: 718 L-PNPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLPCYNGGICVDGVNWF 773
Query: 1074 ACSACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSC--------------- 1117
C C G+ G C ++DEC C + + C
Sbjct: 774 RCE-CAPGF----AGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
Query: 1118 ---KDCDGGYRPSPLGDS-CEDVDECEDPQSSCLGG--EC-KNTVGSYQCL--------- 1161
+ C P P G S ED + C CL G +C K G CL
Sbjct: 829 GFGRSCWSRGTPFPHGSSWVEDCNSCR-----CLDGRRDCSKVWCGWKPCLLAGQPEALS 883
Query: 1162 --CPQG---FQLANGTV----CEDVNECMGEEHCAPHGECLNSHGSFFCLCA 1204
CP G + A G CE EC EE P CL G CA
Sbjct: 884 AQCPLGQRCLEKAPGQCLRPPCEAWGECGAEE--PPSTPCLPRSGHLDNNCA 933
Score = 64.7 bits (156), Expect = 8e-10
Identities = 138/619 (22%), Positives = 206/619 (33%), Gaps = 140/619 (22%)
Query: 1231 GHCVNTEGSFNCLCETGFQPSPESGECVDIDE------CEDYGDPVC-GTW---KCENS- 1279
GH + E C+ + + + C ++ C+ YG+ C W +C+ +
Sbjct: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
Query: 1280 --------------PGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGS 1325
PG RC G Q F DEC C HG C
Sbjct: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRF----------CDECVPYPGC-VHGSCVEP--- 290
Query: 1326 FRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVE-GSFLCLCASDLEEYDAQE 1383
++C C+ + G C D+N C C N E + C C
Sbjct: 291 WQCNCETNW----GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTC----------- 335
Query: 1384 GHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGAS 1443
P G G++ +A +HA T C +G H S EC C G S
Sbjct: 336 ----PDGYSGRNCEKA---EHAC--TSNPCANGGSCHEVPSGF--------ECHCPSGWS 378
Query: 1444 WGDAC----DLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPN 1499
G C D C S A G+ + G T D ++C G C +
Sbjct: 379 -GPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC----RGQCQH 433
Query: 1500 G-RCLNTVPGYVCLCNPGFHYDASHKKCE-DHDECQDLACENGE-CVNTEGSFHCFCSPP 1556
G C + V GY C+C GF + CE + DEC C +G C + FHC C
Sbjct: 434 GGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 489
Query: 1557 LTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDGEA 1616
+ L + + +D+C P R Y +G+
Sbjct: 490 FSGPLCE-----------------VDVDLCEPS--------PCRNGARCYN----LEGDY 520
Query: 1617 WSQQCALCPPRSSEVYAQLCNVARIEAEREA-GVHFRPGYEYGPG-PDDLHYSIYGPDGA 1674
+ CA CP + + C+V R A V G + GPG P + GP G
Sbjct: 521 Y---CA-CP---DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 573
Query: 1675 PFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEG--- 1731
G + + F T H + + A P+G+EG
Sbjct: 574 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
Query: 1732 -LQAEECGILNGCEN-GRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCV 1789
+C + + C + GRC + + C C +G++ H + NG
Sbjct: 634 DTNPNDC-LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG------ 686
Query: 1790 HGYCENTEGSYRCHCSPGY 1808
G C ++ ++RC C PG+
Sbjct: 687 -GTCYDSGDTFRCACPPGW 704
Score = 40.4 bits (93), Expect = 0.016
Identities = 33/92 (35%), Positives = 40/92 (43%), Gaps = 19/92 (20%)
Query: 366 RGHCANS-CERGDTTTLYSQGGHGHDPKSGFRIYFCQI--------PCLNGGRCI---GR 413
R CA+S C G + G H H P+ GF C++ PC NG RC G
Sbjct: 461 RDECASSPCHSGGLCEDLADGFHCHCPQ-GFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 519
Query: 414 DECWCPANSTGKFCHLPIPQPDREP-PGRGSR 444
C CP + GK C +P REP PG R
Sbjct: 520 YYCACPDDFGGKNCSVP-----REPCPGGACR 546
Score = 38.1 bits (87), Expect = 0.079
Identities = 25/91 (27%), Positives = 37/91 (40%), Gaps = 22/91 (24%)
Query: 363 TCARGHCANSCERGD---TTTLYSQGGHGHDPKSGFRIYF--------CQI--------P 403
TC G+ +CE+ + T+ + GG H+ SGF + C + P
Sbjct: 334 TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP 393
Query: 404 CLNGGRCIGRD---ECWCPANSTGKFCHLPI 431
C GG C+ + EC CP G C L +
Sbjct: 394 CAAGGTCVDQVDGFECICPEQWVGATCQLDV 424
Score = 36.2 bits (82), Expect = 0.30
Identities = 21/70 (30%), Positives = 28/70 (40%), Gaps = 9/70 (12%)
Query: 159 PRGRLTGRNVC----GGQCCPGWTTANSTNHCIKPVCEPPCQN-RGSCSRPQLCVCRSGF 213
PR G C C GW C + VC+ C G C+ P C C G+
Sbjct: 213 PRNDFFGHYTCDQYGNKACMDGWMG----KECKEAVCKQGCNLLHGGCTVPGECRCSYGW 268
Query: 214 RGARCEEVIP 223
+G C+E +P
Sbjct: 269 QGRFCDECVP 278
Score = 35.0 bits (79), Expect = 0.67
Identities = 28/92 (30%), Positives = 39/92 (42%), Gaps = 16/92 (17%)
Query: 1728 GFEGL----QAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNG 1783
G+EG +C L G CV + C+C GF A ++++EC +
Sbjct: 742 GWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF---AGPDCRINIDECQ--SS 796
Query: 1784 PAVLCVHGY-CENTEGSYRCHCSPGYVAEAGP 1814
P C +G C + YRC C PG AGP
Sbjct: 797 P---CAYGATCVDEINGYRCSCPPG---RAGP 822
Score = 34.7 bits (78), Expect = 0.87
Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 17/78 (21%)
Query: 1741 NGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDL---NGPAVLCVHGYCENT 1796
N C NG CV ++C C +G++ + N+C+ L NG G C +
Sbjct: 720 NPCVNGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLPCYNG-------GICVDG 769
Query: 1797 EGSYRCHCSPGYVAEAGP 1814
+RC C+PG+ AGP
Sbjct: 770 VNWFRCECAPGF---AGP 784
Score = 32.3 bits (72), Expect = 4.3
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 9/52 (17%)
Query: 173 CCPGW---TTANSTNHCIKPVCEPPCQNRGSC---SRPQLCVCRSGFRGARC 218
C PGW T A + N P PC N G+C C+CR G+ G C
Sbjct: 700 CPPGWKGSTCAVAKNSSCLP---NPCVNGGTCVGSGASFSCICRDGWEGRTC 748
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 191 bits (485), Expect = 6e-48
Identities = 130/415 (31%), Positives = 190/415 (45%), Gaps = 39/415 (9%)
Query: 887 DDNECLR--DPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECE-QPGVCSGG 943
D +EC+ D C C N SY C C GYT G + C+D++ECE +
Sbjct: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT----GDGKHCKDVDECEREDNAGCVH 84
Query: 944 QCTNTEGSYHCECDQGYIMVRKGH-CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY- 1001
C N G+Y C C G+ + GH C D++EC CVN GSY C C EG+
Sbjct: 85 DCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYEC-HCREGFF 143
Query: 1002 -RGQSGSCVDVNE----CLTPGV-CAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDEC 1055
+C+ E C+ CAH +G C C G+E+T +++ C+
Sbjct: 144 LSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNY 203
Query: 1056 ASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSF 1115
+ T C +TE C C + ++ DG C ++ CA C + A
Sbjct: 204 GNGGCQHT--CDDTEQGPRCG-CHIKFVLHTDGKTC--IETCAVNNGGCDSKCHDAATGV 258
Query: 1116 SCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLA-NGTVC 1174
C C G+ P +C+D+DEC C C+NTVGS++C C +G++L N C
Sbjct: 259 HCT-CPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKLLINERNC 316
Query: 1175 EDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCV 1234
+D++EC + C C+N+ GSF CLC G++ G T C DVDEC+ C+
Sbjct: 317 QDIDECSFDRTC--DHICVNTPGSFQCLCHRGYL-LYGITHCGDVDECSINRGGCRFGCI 373
Query: 1235 NTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCENSPGSYRCVLGC 1289
NT GS+ C C G +G+ D +P+ KC+ SPG+ + +L C
Sbjct: 374 NTPGSYQCTCPAGQGRLHWNGK--------DCTEPL----KCQGSPGASKAMLSC 416
Score = 181 bits (460), Expect = 4e-45
Identities = 140/460 (30%), Positives = 182/460 (39%), Gaps = 85/460 (18%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG-KGRCI 903
+D C G N C N P Y+C+C GY +C D +EC R+ G C+
Sbjct: 30 VDECVEGTDNCHIDAICQNTPRSYKCICKSGYT--GDGKHCKDVDECEREDNAGCVHDCV 87
Query: 904 NRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMV 963
N G+Y C CY G+ LA G C D++EC + C N GSY C C +G+ +
Sbjct: 88 NIPGNYRCTCYDGFHLAHDG--HNCLDVDECAEGNGGCQQSCVNMMGSYECHCREGFFLS 145
Query: 964 RKGH-----------CQDINE-CRH-PGTCPDG--RCVNSPG------SYTC-LACEEGY 1001
H C + N C H P G C PG C L C G
Sbjct: 146 DNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGN 205
Query: 1002 RGQSGSCVD----------------------VNECLTPGVCAHGKCTNLEGSFRCSCEQG 1039
G +C D + C KC + C+C G
Sbjct: 206 GGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVG 265
Query: 1040 YEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF 1099
+ + D K C+D+DEC +C NT GSF CS C+ GY + + C+D+DEC+F
Sbjct: 266 FMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECS-CKKGYKLLINERNCQDIDECSF 324
Query: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
C +C NT GSF C C GY + C DVDEC + C G C NT GSYQ
Sbjct: 325 DRTC-DHICVNTPGSFQCL-CHRGYLLYGI-THCGDVDECSINRGGCRFG-CINTPGSYQ 380
Query: 1160 CLCP--QGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ 1217
C CP QG NG C + +C G +PG +++ SC
Sbjct: 381 CTCPAGQGRLHWNGKDCTEPLKCQG---------------------SPG--ASKAMLSCN 417
Query: 1218 ---DVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPES 1254
D CA T P +E F C T PSP +
Sbjct: 418 RSGKKDTCALTCPSRARFLPESENGFTVSCGT---PSPRA 454
Score = 168 bits (426), Expect = 4e-41
Identities = 119/393 (30%), Positives = 178/393 (45%), Gaps = 27/393 (6%)
Query: 969 QDINEC-RHPGTCP-DGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTP--GVCAHGK 1024
QD++EC C D C N+P SY C+ C+ GY G C DV+EC C H
Sbjct: 28 QDVDECVEGTDNCHIDAICQNTPRSYKCI-CKSGYTGDGKHCKDVDECEREDNAGCVHD- 85
Query: 1025 CTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWV 1084
C N+ G++RC+C G+ + D C DVDECA C+N GS+ C C G+++
Sbjct: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECH-CREGFFL 144
Query: 1085 NEDGTAC----EDLDECAFPGVCPSGVCTNTA-GSFSCKDCDGGYRPSPLGDSCEDVDEC 1139
+++ C E+ C + +C T G +C +C G+ + C+ C
Sbjct: 145 SDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIAC-ECRPGFELTKNQRDCKLT--C 201
Query: 1140 EDPQSSCLGGECKNTVGSYQCLCPQGFQL-ANGTVCEDVNECMGEEHCAPHGECLNSHGS 1198
C C +T +C C F L +G C E + +C ++
Sbjct: 202 NYGNGGCQH-TCDDTEQGPRCGCHIKFVLHTDGKTCI---ETCAVNNGGCDSKCHDAATG 257
Query: 1199 FFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECV 1258
C C GF+ +C+D+DEC + C NT GSF C C+ G++ C
Sbjct: 258 VHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQ 317
Query: 1259 DIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGF 1318
DIDEC D C C N+PGS++C+ C G+ + C D+DEC+ + G
Sbjct: 318 DIDECS--FDRTC-DHICVNTPGSFQCL--CHRGYLLYGITHCGDVDECSIN-RGGCRFG 371
Query: 1319 CDNTDGSFRCLCDQG-FEISPSGWDCVDVNECE 1350
C NT GS++C C G + +G DC + +C+
Sbjct: 372 CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQ 404
Score = 131 bits (330), Expect = 5e-30
Identities = 119/431 (27%), Positives = 170/431 (39%), Gaps = 67/431 (15%)
Query: 1125 RPSPLGDSCEDVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGE 1183
R + + +DVDEC + +C + C+NT SY+C+C G+ +G C+DV+EC E
Sbjct: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYT-GDGKHCKDVDECERE 77
Query: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCL 1243
++ +C+N G++ C C GF A G +C DVDECA + CVN GS+ C
Sbjct: 78 DNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECH 137
Query: 1244 CETGFQPSPESGECVDIDE----C--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAP 1297
C GF S C+ E C +++G C E G C C+PGF +
Sbjct: 138 CREGFFLSDNQHTCIQRPEEGMNCMNKNHG---CAHICRETPKGGIAC--ECRPGFELTK 192
Query: 1298 NGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCG 1357
N D N G CD+T+ RC C F + G C++ C + C
Sbjct: 193 NQR--DCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIET--CAVNNGGCD 248
Query: 1358 AALCENVEGSFLCLC------------ASDLEEYDAQEGHCRPRGAGGQSMSEAPTGDHA 1405
+ C + C C D++E CR G + G
Sbjct: 249 SK-CHDAATGVHCTCPVGFMLQPDRKTCKDIDE-------CRLNNGGCDHICRNTVGSF- 299
Query: 1406 PAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPS 1465
C G K + RN + C S+ CD F +C
Sbjct: 300 ----ECSCKKGYK-----LLINERNCQDIDEC-----SFDRTCDHICVNTPGSFQCLC-- 343
Query: 1466 GKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPG---FHYDAS 1522
+GY+ +G T D DEC I G C G C+NT Y C C G H++
Sbjct: 344 HRGYL------LYGITHCGDVDECSI-NRGGCRFG-CINTPGSYQCTCPAGQGRLHWNG- 394
Query: 1523 HKKCEDHDECQ 1533
K C + +CQ
Sbjct: 395 -KDCTEPLKCQ 404
Score = 122 bits (306), Expect = 3e-27
Identities = 109/382 (28%), Positives = 151/382 (39%), Gaps = 55/382 (14%)
Query: 1209 SAEGGTSCQDVDECAT-TDPC-VGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDY 1266
+A+ + QDVDEC TD C + C NT S+ C+C++G+ + + C D+DECE
Sbjct: 20 AAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY--TGDGKHCKDVDECERE 77
Query: 1267 GDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGS 1325
+ C C N PG+YRC C GFH+A +G +C+D+DECA G C N GS
Sbjct: 78 DNAGC-VHDCVNIPGNYRCT--CYDGFHLAHDGHNCLDVDECAEGNG-GCQQSCVNMMGS 133
Query: 1326 FRCLCDQGFEISPSGWDCVDVNE----CELMLAVCGAALCENVEGSFLCLCASDLEEYDA 1381
+ C C +GF +S + C+ E C C E +G C C E
Sbjct: 134 YECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKN 193
Query: 1382 QEGHCRPR---GAGG--QSMSEAPTGDHAPAPTRMDCYSGQK--------GHAPCSSVLG 1428
Q C+ G GG + + G + ++ K + C S
Sbjct: 194 QRD-CKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCH 252
Query: 1429 RNTTQAECCCTQGASWGDACDLCPSEDSAEFSE--------------ICPSGKGYIPVEG 1474
T C C G C D + C KGY
Sbjct: 253 DAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGY----- 307
Query: 1475 AWTFGQTMYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFH-YDASHKKCEDHDECQ 1533
+ D DEC C + C+NT + CLC+ G+ Y +H C D DEC
Sbjct: 308 KLLINERNCQDIDECSF--DRTCDH-ICVNTPGSFQCLCHRGYLLYGITH--CGDVDECS 362
Query: 1534 DL--ACENGECVNTEGSFHCFC 1553
C G C+NT GS+ C C
Sbjct: 363 INRGGCRFG-CINTPGSYQCTC 383
Score = 81.3 bits (199), Expect = 8e-15
Identities = 83/335 (24%), Positives = 114/335 (34%), Gaps = 67/335 (20%)
Query: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQ---DLACENGE 1541
D DECV + C NT Y C+C G+ D H C+D DEC+ + C + +
Sbjct: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKH--CKDVDECEREDNAGCVH-D 85
Query: 1542 CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRG 1601
CVN G++ C C L C++ E N C +
Sbjct: 86 CVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEG----------------NGGCQQSCVN 129
Query: 1602 HRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL------CNVARIEAEREAGVHFRPGY 1655
+Y EC C++G S C R E + ++ R + RPG+
Sbjct: 130 MMGSY-ECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGF 188
Query: 1656 EYGPGPDDLHYSI-YGPDGAPFYNYLGPEDTVPEPAFPNTAGHSADRTPILESPLQPSEL 1714
E D + YG G H+ D T
Sbjct: 189 ELTKNQRDCKLTCNYGNGGCQ---------------------HTCDDTE----------- 216
Query: 1715 QPHYVASHPEPPAGFEGLQA-EECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACV 1773
Q H + +G E C + NG + +C G C C GF L C
Sbjct: 217 QGPRCGCHIKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCK 276
Query: 1774 DVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
D++EC NG C H C NT GS+ C C GY
Sbjct: 277 DIDECRLNNGG---CDH-ICRNTVGSFECSCKKGY 307
Score = 54.7 bits (130), Expect = 8e-07
Identities = 120/543 (22%), Positives = 183/543 (33%), Gaps = 94/543 (17%)
Query: 605 QLECPQGYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGL---------ML 654
Q C +GY +THC D++EC + G C+ C+NT GSY CTC G
Sbjct: 340 QCLCHRGYLLYGITHCGDVDECSINRGGCRFG-CINTPGSYQCTCPAGQGRLHWNGKDCT 398
Query: 655 DPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAWGSE---CEK 711
+P +C S C RS TC L C SR SE
Sbjct: 399 EP--LKCQGSPGASKAMLSCNRSGKKDTCAL----------TCPSRARFLPESENGFTVS 446
Query: 712 CPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAERQ 771
C P A PA G+ S++ S E L+ QR+S + R
Sbjct: 447 CGTPSPRA----APARAGHNGNSTN---SNHCHEAAVLSIK-----QRASFKIKDAKCRL 494
Query: 772 PLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVT-----GNATTPPMPE------Q 820
LR T EAG I G + + + H + A TPP E +
Sbjct: 495 HLRNKGKT-EEAGRITGPGGAPCSECQVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLE 553
Query: 821 GIAEIQEEQVTPSTDVLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHP 880
AE++ E+ T S + ++R G+ + +N + Y+L
Sbjct: 554 LEAEVRAEETTASCG--LPCLRQRMERRLKGSLKMLRKS--INQDRFLLRLAGLDYELAH 609
Query: 881 SQAYCTDDNECLRDPCKGKGRCINRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVC 940
+ + C+ G+ +R G+ C G G T++C C
Sbjct: 610 KPGLVAGERAEPMESCR-PGQ--HRAGTKCVSCPQG--TYYHGQTEQCVP---------C 655
Query: 941 SGGQCTNTEGSYHCECDQG----------YIMVRKGHC----QDINECRHPGTCPDGRCV 986
G EG C+ G + G C ++ + CP G
Sbjct: 656 PAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPRGTYQ 715
Query: 987 NSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHGKC--TNLEGSFRCSCEQGYEVTS 1044
G C C G + + +C T C+ G T++ RC+ Y+
Sbjct: 716 PEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSPGHYYNTSIHRCIRCAM-GSYQPDF 774
Query: 1045 DEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAFPGVCP 1104
+ C + CP + +GS + + C+N E G ++ +PG P
Sbjct: 775 RQNFC---------SRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYP 825
Query: 1105 SGV 1107
+GV
Sbjct: 826 AGV 828
Score = 39.7 bits (91), Expect = 0.027
Identities = 22/62 (35%), Positives = 32/62 (51%), Gaps = 3/62 (4%)
Query: 603 NGQLECPQGYKRLNLTH-CQDINECLT-LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSR 660
N + C G+ + H C D++EC G C+ + CVN GSY C CR G L ++
Sbjct: 92 NYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQS-CVNMMGSYECHCREGFFLSDNQHT 150
Query: 661 CV 662
C+
Sbjct: 151 CI 152
Score = 37.4 bits (85), Expect = 0.13
Identities = 24/73 (32%), Positives = 32/73 (43%), Gaps = 6/73 (8%)
Query: 608 CPQGYKRLNLTHCQDINECL---TLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
C GY + HC+D++EC G D CVN G+Y CTC G L C+
Sbjct: 57 CKSGYTG-DGKHCKDVDECEREDNAGCVHD--CVNIPGNYRCTCYDGFHLAHDGHNCLDV 113
Query: 665 KAISMLQGLCYRS 677
+ G C +S
Sbjct: 114 DECAEGNGGCQQS 126
Score = 37.4 bits (85), Expect = 0.13
Identities = 97/481 (20%), Positives = 141/481 (29%), Gaps = 104/481 (21%)
Query: 861 CVNLPDGYRCVCSPGY-QLHPSQAYCTDDNECLRDP--------CKGKGR-------CIN 904
C+N P Y+C C G +LH + CT+ +C P C G+ C +
Sbjct: 372 CINTPGSYQCTCPAGQGRLHWNGKDCTEPLKCQGSPGASKAMLSCNRSGKKDTCALTCPS 431
Query: 905 RV-------GSYSCFC---YPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHC 954
R ++ C P A +G + N C + V S Q S+
Sbjct: 432 RARFLPESENGFTVSCGTPSPRAAPARAGHNGNSTNSNHCHEAAVLSIKQ----RASFKI 487
Query: 955 ECDQGYIMVR-KGHCQDINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSC----- 1008
+ + + +R KG ++ PG P C ++ L C+ +G+
Sbjct: 488 KDAKCRLHLRNKGKTEEAGRITGPGGAPCSEC---QVTFIHLKCDSSRKGKGRRARTPPG 544
Query: 1009 -----------VDVNECLTPGVCA-----HGKCTNLEGSF---RCSCEQG---------- 1039
+V T C L+GS R S Q
Sbjct: 545 KEVTRLTLELEAEVRAEETTASCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLD 604
Query: 1040 YEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACEDLDECAF 1099
YE+ + + G + SC G C +C G + + C
Sbjct: 605 YEL-AHKPGLVAGERAEPMESCRPG---QHRAGTKCVSCPQGTYYHGQTEQCVP------ 654
Query: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLG--------DSCEDVDECED---PQSSCLG 1148
CP+G G SC C G PLG C D P C
Sbjct: 655 ---CPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGQHSVDGFKPCQPCPR 711
Query: 1149 GECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPG-- 1206
G + G C G +C + C+P G N+ CA G
Sbjct: 712 GTYQPEAGRTLCFPCGGGLTTKHEGAISFQDCDTKVQCSP-GHYYNTSIHRCIRCAMGSY 770
Query: 1207 -------FVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPS--PESGEC 1257
F S G + D D + C C G F E+ P P EC
Sbjct: 771 QPDFRQNFCSRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVEC 830
Query: 1258 V 1258
+
Sbjct: 831 I 831
Score = 37.0 bits (84), Expect = 0.18
Identities = 40/134 (29%), Positives = 56/134 (41%), Gaps = 19/134 (14%)
Query: 608 CPQGYK-RLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDK 665
CP G+ + + C+DI+EC L G C D C NT GS+ C+C+ G L + C
Sbjct: 262 CPVGFMLQPDRKTCKDIDECRLNNGGC-DHICRNTVGSFECSCKKGYKLLINERNCQDID 320
Query: 666 AISM---LQGLCYRSLGPGTCTLP---LAQRITK----QICCCSRVGKAWGSECEKCPLP 715
S +C + G C L IT C +R G +G C P
Sbjct: 321 ECSFDRTCDHICVNTPGSFQCLCHRGYLLYGITHCGDVDECSINRGGCRFG--CINTP-- 376
Query: 716 GTEAFREICPAGHG 729
+++ CPAG G
Sbjct: 377 --GSYQCTCPAGQG 388
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 189 bits (481), Expect = 2e-47
Identities = 128/427 (29%), Positives = 181/427 (42%), Gaps = 31/427 (7%)
Query: 845 IDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG--KGRC 902
+D C+ G + C N P Y+C+C PGY+ Q C D +EC D G C
Sbjct: 34 VDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGGCVHEC 91
Query: 903 INRVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIM 962
IN G+Y C C+ G+ LA G C D++EC+ C N GSY C+C G+ +
Sbjct: 92 INIPGNYRCTCFDGFMLAHDG--HNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
Query: 963 VRKGH-----CQDINECRHPGTCPDGRCVNSPGSYTCLACEEGY---RGQSGSCVDVNEC 1014
H + C + C +P C G+ + Q + N
Sbjct: 150 SDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTCN-- 207
Query: 1015 LTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFA 1074
G C H C + + C C Q Y + SD + C ++ CA C +T
Sbjct: 208 YGNGGCQH-SCEDTDTGPTCGCHQKYALHSDGRTC--IETCAVNNGGCDRTCKDTATGVR 264
Query: 1075 CSACENGYWVNEDGTACEDLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE 1134
CS C G+ + DG C+D++EC C NT GSF C C GY+ +C+
Sbjct: 265 CS-CPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFEC-GCRKGYKLLTDERTCQ 322
Query: 1135 DVDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHGECLN 1194
D+DEC ++ C N+ GS+QCLC +G+ L T C DV+EC G C+N
Sbjct: 323 DIDECSFERT--CDHICINSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQG-CVN 379
Query: 1195 SHGSFFCLCAPGFVSAEGGTSCQDVDEC---ATTDPCVGGHCVNTEG----SFNCLCETG 1247
+ GS+ C+C PG G C + +C A T P C G +C T
Sbjct: 380 TKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTL 439
Query: 1248 FQPSPES 1254
F P E+
Sbjct: 440 FVPDSEN 446
Score = 184 bits (466), Expect = 9e-46
Identities = 124/401 (30%), Positives = 188/401 (46%), Gaps = 47/401 (11%)
Query: 970 DINECRHPGTCP---DGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTP---GVCAHG 1023
D++EC GT D C N+P SY CL C+ GY+G+ C D++EC G C H
Sbjct: 33 DVDECSE-GTDDCHIDAICQNTPKSYKCL-CKPGYKGEGKQCEDIDECENDYYNGGCVH- 89
Query: 1024 KCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYW 1083
+C N+ G++RC+C G+ + D C DVDEC +C+N GS+ C C +G++
Sbjct: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQ-CHSGFF 148
Query: 1084 VNEDGTAC----EDLDECAFPGVCPSGVCTNTA-GSFSCKDCDGGYRPSPLGDSCEDVDE 1138
++++ C + C + +C T G +C DC G+ D ++ +
Sbjct: 149 LSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVAC-DCRPGF------DLAQNQKD 201
Query: 1139 CEDPQSSCLGG---ECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEHCAPHG----- 1190
C + GG C++T C C Q + L + D C+ E CA +
Sbjct: 202 CTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHS-----DGRTCI--ETCAVNNGGCDR 254
Query: 1191 ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQP 1250
C ++ C C GF G +C+D++EC + C NT GSF C C G++
Sbjct: 255 TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKL 314
Query: 1251 SPESGECVDIDEC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECA 1308
+ C DIDEC E D +C NSPGS++C+ C G+ + C D+DEC+
Sbjct: 315 LTDERTCQDIDECSFERTCDHIC-----INSPGSFQCL--CHRGYILYGTTHCGDVDECS 367
Query: 1309 NDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNEC 1349
G C NT GS+ C+C G + +G DCV+ +C
Sbjct: 368 MSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
Score = 144 bits (363), Expect = 8e-34
Identities = 130/473 (27%), Positives = 173/473 (36%), Gaps = 121/473 (25%)
Query: 1135 DVDECEDPQSSC-LGGECKNTVGSYQCLCPQGFQLANGTVCEDVNECMGEEH---CAPHG 1190
DVDEC + C + C+NT SY+CLC G++ G CED++EC + + C
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDYYNGGCVH-- 89
Query: 1191 ECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQP 1250
EC+N G++ C C GF+ A G +C DVDEC + CVN GS+ C C +GF
Sbjct: 90 ECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFL 149
Query: 1251 SPESGECVDID----EC--EDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPN-GDCI- 1302
S C+ C +D+G C E G C C+PGF +A N DC
Sbjct: 150 SDNQHTCIHRSNEGMNCMNKDHG---CAHICRETPKGGVAC--DCRPGFDLAQNQKDCTL 204
Query: 1303 -----------DIDECANDTMCGSH--------------------GFCD----NTDGSFR 1327
++ CG H G CD +T R
Sbjct: 205 TCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVR 264
Query: 1328 CLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCR 1387
C C GF + P G C D+NEC + C C N GSF C C
Sbjct: 265 CSCPVGFTLQPDGKTCKDINECLVNNGGCD-HFCRNTVGSFECGC--------------- 308
Query: 1388 PRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDA 1447
+KG+ T + C S+
Sbjct: 309 -----------------------------RKGYKLL-------TDERTCQDIDECSFERT 332
Query: 1448 CDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPNGRCLNTVP 1507
CD F +C +GYI +G T D DEC + G C G C+NT
Sbjct: 333 CDHICINSPGSFQCLC--HRGYI------LYGTTHCGDVDECSM-SNGSCDQG-CVNTKG 382
Query: 1508 GYVCLCNPGFHYDASHKKCEDHDECQDLACENG----ECVNTEGSFHCFCSPP 1556
Y C+C PG + K C + +C A + C G CF S P
Sbjct: 383 SYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCP 435
Score = 125 bits (315), Expect = 3e-28
Identities = 114/391 (29%), Positives = 160/391 (40%), Gaps = 58/391 (14%)
Query: 1218 DVDECAT-TDPC-VGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECE-DYGDPVCGTW 1274
DVDEC+ TD C + C NT S+ CLC+ G++ E +C DIDECE DY + C
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKG--EGKQCEDIDECENDYYNGGC-VH 89
Query: 1275 KCENSPGSYRCVLGCQPGFHMAPNG-DCIDIDECANDTMCGSHGFCDNTDGSFRCLCDQG 1333
+C N PG+YRC C GF +A +G +C+D+DEC D G C N GS+ C C G
Sbjct: 90 ECINIPGNYRCT--CFDGFMLAHDGHNCLDVDEC-QDNNGGCQQICVNAMGSYECQCHSG 146
Query: 1334 FEISPSGWDCVDVNE----CELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEG---HC 1386
F +S + C+ + C C E +G C C + Q+ C
Sbjct: 147 FFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKDCTLTC 206
Query: 1387 RPRGAGGQ-SMSEAPTGDHAPAPTRMDCYSGQK--------GHAPCSSVLGRNTTQAECC 1437
G Q S + TG + +S + + C T C
Sbjct: 207 NYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDTATGVRCS 266
Query: 1438 CTQGASW----------------GDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQT 1481
C G + CD F C KGY + T
Sbjct: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFE--CGCRKGYKLLTDERTC--- 321
Query: 1482 MYTDADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFH-YDASHKKCEDHDECQ--DLACE 1538
D DEC C + C+N+ + CLC+ G+ Y +H C D DEC + +C+
Sbjct: 322 --QDIDECSF--ERTCDH-ICINSPGSFQCLCHRGYILYGTTH--CGDVDECSMSNGSCD 374
Query: 1539 NGECVNTEGSFHCFCSPPLTLDLSQQRCMNS 1569
G CVNT+GS+ C C P L + + C+ +
Sbjct: 375 QG-CVNTKGSYECVCPPGRRLHWNGKDCVET 404
Score = 117 bits (294), Expect = 8e-26
Identities = 97/329 (29%), Positives = 138/329 (41%), Gaps = 32/329 (9%)
Query: 1258 VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHG 1317
VD+DEC + D C+N+P SY+C+ C+PG+ C DIDEC ND G
Sbjct: 32 VDVDECSEGTDDCHIDAICQNTPKSYKCL--CKPGYK-GEGKQCEDIDECENDYYNGGCV 88
Query: 1318 F-CDNTDGSFRCLCDQGFEISPSGWDCVDVNECELMLAVCGAALCENVEGSFLCLCASDL 1376
C N G++RC C GF ++ G +C+DV+EC+ C +C N GS+ C C S
Sbjct: 89 HECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGC-QQICVNAMGSYECQCHSGF 147
Query: 1377 EEYDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAEC 1436
D Q G M++ DH A C KG C G + Q +
Sbjct: 148 FLSDNQHTCIHRSNEGMNCMNK----DHGCAHI---CRETPKGGVACDCRPGFDLAQNQK 200
Query: 1437 CCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECV---IFG 1493
CT ++G+ ED+ + C + Y +++D C+
Sbjct: 201 DCTLTCNYGNGGCQHSCEDT-DTGPTCGCHQKY-----------ALHSDGRTCIETCAVN 248
Query: 1494 PGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDEC--QDLACENGECVNTEGSFHC 1551
G C C +T G C C GF K C+D +EC + C++ C NT GSF C
Sbjct: 249 NGGCDR-TCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHF-CRNTVGSFEC 306
Query: 1552 FCSPPLTLDLSQQRCMN-STSSTEDLPDH 1579
C L ++ C + S E DH
Sbjct: 307 GCRKGYKLLTDERTCQDIDECSFERTCDH 335
Score = 90.1 bits (222), Expect = 2e-17
Identities = 91/337 (27%), Positives = 117/337 (34%), Gaps = 70/337 (20%)
Query: 1485 DADECVIFGPGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACENG---E 1541
D DEC + C NT Y CLC PG Y K+CED DEC++ G E
Sbjct: 33 DVDECSEGTDDCHIDAICQNTPKSYKCLCKPG--YKGEGKQCEDIDECENDYYNGGCVHE 90
Query: 1542 CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEPLRG 1601
C+N G++ C C L C++ +D C + N C +
Sbjct: 91 CINIPGNYRCTCFDGFMLAHDGHNCLD--------------VDEC--QDNNGGCQQICVN 134
Query: 1602 HRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQL------CNVARIEAEREAGVHFRPGY 1655
+Y EC C G S C RS+E + ++ R + RPG+
Sbjct: 135 AMGSY-ECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVACDCRPGF 193
Query: 1656 EYGPGPDDLHYSI-YGPDGAPFYNYLGPEDTVPEPA---FPNTAGHSADRTPILESPLQP 1711
+ D + YG G EDT P A HS RT I
Sbjct: 194 DLAQNQKDCTLTCNYGNGGCQH----SCEDTDTGPTCGCHQKYALHSDGRTCI------- 242
Query: 1712 SELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMA 1771
E C + NG + C G C C GF L
Sbjct: 243 -----------------------ETCAVNNGGCDRTCKDTATGVRCSCPVGFTLQPDGKT 279
Query: 1772 CVDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
C D+NEC NG C H +C NT GS+ C C GY
Sbjct: 280 CKDINECLVNNGG---CDH-FCRNTVGSFECGCRKGY 312
Score = 53.1 bits (126), Expect = 2e-06
Identities = 27/59 (45%), Positives = 34/59 (57%), Gaps = 2/59 (3%)
Query: 605 QLECPQGYKRLNLTHCQDINEC-LTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
Q C +GY THC D++EC ++ G C D CVNT+GSY C C PG L + CV
Sbjct: 345 QCLCHRGYILYGTTHCGDVDECSMSNGSC-DQGCVNTKGSYECVCPPGRRLHWNGKDCV 402
Score = 44.3 bits (103), Expect = 0.001
Identities = 33/101 (32%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 608 CPQGYKRLNLTH-CQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKA 666
C +GYK L CQDI+EC C D C+N+ GS+ C C G +L + C
Sbjct: 308 CRKGYKLLTDERTCQDIDECSFERTC-DHICINSPGSFQCLCHRGYIL-YGTTHCGDVDE 365
Query: 667 ISMLQGL----CYRSLGPGTCTLPLAQRITKQICCCSRVGK 703
SM G C + G C P +R+ C GK
Sbjct: 366 CSMSNGSCDQGCVNTKGSYECVCPPGRRLHWNGKDCVETGK 406
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/92 (29%), Positives = 32/92 (34%), Gaps = 1/92 (1%)
Query: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVD-VNECDDLNGPAV 1786
G L +EC NG CV Y C C GF L C+ NE +
Sbjct: 112 GHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDH 171
Query: 1787 LCVHGYCENTEGSYRCHCSPGYVAEAGPPHCT 1818
C H E +G C C PG+ CT
Sbjct: 172 GCAHICRETPKGGVACDCRPGFDLAQNQKDCT 203
Score = 40.0 bits (92), Expect = 0.021
Identities = 23/72 (31%), Positives = 35/72 (48%), Gaps = 8/72 (11%)
Query: 1748 CVRVREGYTCDCFEGFQLDAAHMACVDVNECDD--LNGPAVLCVHGYCENTEGSYRCHCS 1805
C + Y C C G++ + C D++EC++ NG CVH C N G+YRC C
Sbjct: 50 CQNTPKSYKCLCKPGYKGEGKQ--CEDIDECENDYYNGG---CVHE-CINIPGNYRCTCF 103
Query: 1806 PGYVAEAGPPHC 1817
G++ +C
Sbjct: 104 DGFMLAHDGHNC 115
Score = 40.0 bits (92), Expect = 0.021
Identities = 51/211 (24%), Positives = 69/211 (32%), Gaps = 52/211 (24%)
Query: 978 GTCPDGRCVNSPGSYTCLACEEG--YRGQSGSCVDVNECLTPGVCAHGKCTNLEGSFRCS 1035
G C G+ + C+AC G + G+ G CV C G ++EG C+
Sbjct: 617 GACGAGQVLQDS---KCVACGPGTHFGGELGQCVS---------CMPGTYQDMEGQLSCT 664
Query: 1036 -CEQGYEVTSDEKGCQDVDECASRAS--------------CPTGLCLNTEGSFACSACEN 1080
C + G ++V EC + S CP G G C C
Sbjct: 665 PCPSSDGLGLP--GARNVSECGGQCSPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGG 722
Query: 1081 GYWVNEDGTA----CEDLDECAFPG-----------VCPSGVCTNTAGSFSCKDCDGGYR 1125
G +GT CE C+ PG CP G G C C G
Sbjct: 723 GLLTKHEGTTSFQDCEAKVHCS-PGHHYNTTTHRCIRCPVGTYQPEFGQNHCITCPG--N 779
Query: 1126 PSPLGDSCEDVDECEDPQSSCLGGECKNTVG 1156
S D +V C++ GGE + G
Sbjct: 780 TSTDFDGSTNVTHCKNQH---CGGELGDYTG 807
Score = 39.3 bits (90), Expect = 0.035
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 9/83 (10%)
Query: 608 CPQGYKRLNLTHCQDINECLT---LGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSD 664
C GYK C+DI+EC G C EC+N G+Y CTC G ML C+
Sbjct: 61 CKPGYKGEG-KQCEDIDECENDYYNGGCVH-ECINIPGNYRCTCFDGFMLAHDGHNCLDV 118
Query: 665 KAISMLQG----LCYRSLGPGTC 683
G +C ++G C
Sbjct: 119 DECQDNNGGCQQICVNAMGSYEC 141
Score = 38.5 bits (88), Expect = 0.060
Identities = 22/55 (40%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 608 CPQGYK-RLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRC 661
CP G+ + + C+DINECL D C NT GS+ C CR G L C
Sbjct: 267 CPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTC 321
Score = 37.7 bits (86), Expect = 0.10
Identities = 20/60 (33%), Positives = 29/60 (48%), Gaps = 6/60 (10%)
Query: 603 NGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCV 662
+G + G+ L++ CQD N G C+ CVN GSY C C G L ++ C+
Sbjct: 104 DGFMLAHDGHNCLDVDECQDNN-----GGCQQI-CVNAMGSYECQCHSGFFLSDNQHTCI 157
Score = 37.4 bits (85), Expect = 0.13
Identities = 17/39 (43%), Positives = 22/39 (56%), Gaps = 2/39 (5%)
Query: 1773 VDVNECDDLNGPAVLCVHGYCENTEGSYRCHCSPGYVAE 1811
VDV+EC + G + C+NT SY+C C PGY E
Sbjct: 32 VDVDECSE--GTDDCHIDAICQNTPKSYKCLCKPGYKGE 68
Score = 32.0 bits (71), Expect = 5.6
Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 2/45 (4%)
Query: 1735 EECGILNG-CENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNEC 1778
+EC + NG C+ G CV + Y C C G +L CV+ +C
Sbjct: 364 DECSMSNGSCDQG-CVNTKGSYECVCPPGRRLHWNGKDCVETGKC 407
Score = 31.6 bits (70), Expect = 7.4
Identities = 47/179 (26%), Positives = 60/179 (33%), Gaps = 43/179 (24%)
Query: 1145 SCLGGECKNTVGSYQCL-CPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLC 1203
SC+ G ++ G C CP L +V+EC G+ C
Sbjct: 648 SCMPGTYQDMEGQLSCTPCPSSDGLGLPGA-RNVSECGGQ-------------------C 687
Query: 1204 APGFVSAEGGTSCQDV------DECATTD--PCVGGHCVNTEGSFNCLCETGFQPSPESG 1255
+PGF SA+G CQ E T PC GG EG+ T FQ
Sbjct: 688 SPGFFSADGFKPCQACPVGTYQPEPGRTGCFPCGGGLLTKHEGT------TSFQ------ 735
Query: 1256 ECVDIDECEDYGDPVCGTWKCENSP-GSYRCVLGCQPGFHMAPNGDCIDIDECANDTMC 1313
+C C T +C P G+Y+ G Q P D D N T C
Sbjct: 736 DCEAKVHCSPGHHYNTTTHRCIRCPVGTYQPEFG-QNHCITCPGNTSTDFDGSTNVTHC 793
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 188 bits (477), Expect = 5e-47
Identities = 195/689 (28%), Positives = 276/689 (40%), Gaps = 136/689 (19%)
Query: 854 NVCGP-------GTCVNL-PDGYRCVCSPGYQLHPSQAYCT-DDNECLRDPCKGKGRCIN 904
N CG GTC N PD Y+C C GY S C ++ CL DPC +G C
Sbjct: 298 NYCGTHQPCLNGGTCSNTGPDKYQCSCPEGY----SGPNCEIAEHACLSDPCHNRGSCKE 353
Query: 905 RVGSYSCFCYPGYTLATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVR 964
+ C C PG+T T +I++C GG C + + C C +
Sbjct: 354 TSLGFECECSPGWTGPTCST-----NIDDCSPNNCSHGGTCQDLVNGFKCVCPPQW---T 405
Query: 965 KGHCQ-DINECRHPGTCPDGRCVNSPGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAH- 1022
CQ D NEC C N SY C C G+ GQ+ +++N+CL G C +
Sbjct: 406 GKTCQLDANECEAKPCVNAKSCKNLIASYYC-DCLPGWMGQNCD-ININDCL--GQCQND 461
Query: 1023 GKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGY 1082
C +L +RC C GY E+ D+DECAS G C N F C C G+
Sbjct: 462 ASCRDLVNGYRCICPPGYAGDHCER---DIDECASNPCLNGGHCQNEINRFQC-LCPTGF 517
Query: 1083 WVNEDGTACE-DLDECAFPGVCPSGV-CTNTAGSFSCKDCDGGYRP---SPLGD-----S 1132
G C+ D+D C P C +G C N A + CK C Y S L D
Sbjct: 518 ----SGNLCQLDIDYCE-PNPCQNGAQCYNRASDYFCK-CPEDYEGKNCSHLKDHCRTTP 571
Query: 1133 CEDVDEC-------EDPQ------SSCLG--GECKN-TVGSYQCLCPQGFQLANGTVC-E 1175
CE +D C + P+ S+ G G+CK+ + G + C C +GF GT C E
Sbjct: 572 CEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGF---TGTYCHE 628
Query: 1176 DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVGGHCVN 1235
++N+C C G C++ S+ C+C+ G+ EG ++++C+ GG C +
Sbjct: 629 NINDCESNP-CRNGGTCIDGVNSYKCICSDGW---EGAYCETNINDCSQNPCHNGGTCRD 684
Query: 1236 TEGSFNCLCETGFQPSP--------ESGECVDIDECEDYGDP---VC-GTWK---CENSP 1280
F C C+ G++ + C + C D GD +C G W+ C +
Sbjct: 685 LVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR 744
Query: 1281 GSYRCVLGCQPGFHMAPNGD---CI-----DIDECANDT------MCGSHGFCDNTDGSF 1326
S C G NG+ C+ + CA +T C + G C + D +
Sbjct: 745 NSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWY 804
Query: 1327 RCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGH 1385
RC C GF +G DC +++NEC+ GA + + G + C+C QE
Sbjct: 805 RCECAPGF----AGPDCRININECQSSPCAFGATCVDEING-YRCVCPPGHSGAKCQEVS 859
Query: 1386 CRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQ--KGHAPCSSVLGRNTTQAECCCTQGAS 1443
RP G + + D DC + Q G CS V
Sbjct: 860 GRPCITMGSVIPDGAKWDD-------DCNTCQCLNGRIACSKV----------------- 895
Query: 1444 WGDACDLCPSEDSAEFSEICPSGKGYIPV 1472
W C P SE CPSG+ IP+
Sbjct: 896 W---CGPRPCLLHKGHSE-CPSGQSCIPI 920
Score = 178 bits (452), Expect = 4e-44
Identities = 164/613 (26%), Positives = 248/613 (40%), Gaps = 132/613 (21%)
Query: 839 TLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKG 898
T ST ID C+ N GTC +L +G++CVC P + Q D NEC PC
Sbjct: 370 TCST-NIDDCSPN--NCSHGGTCQDLVNGFKCVCPPQWTGKTCQL---DANECEAKPCVN 423
Query: 899 KGRCINRVGSYSCFCYPGYT-----LATSGATQECQ------------------------ 929
C N + SY C C PG+ + + +CQ
Sbjct: 424 AKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDH 483
Query: 930 ---DINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH-CQ-DINECRHPGTCPDG- 983
DI+EC +GG C N + C C G+ G+ CQ DI+ C P C +G
Sbjct: 484 CERDIDECASNPCLNGGHCQNEINRFQCLCPTGF----SGNLCQLDIDYCE-PNPCQNGA 538
Query: 984 RCVNSPGSYTCLACEEGYRGQSGS----------CVDVNEC---------------LTPG 1018
+C N Y C C E Y G++ S C ++ C ++
Sbjct: 539 QCYNRASDYFC-KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSN 597
Query: 1019 VCA-HGKCTNLEGS-FRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEGSFACS 1076
VC HGKC + G F C C +G+ T +++++C S G C++ S+ C
Sbjct: 598 VCGPHGKCKSQSGGKFTCDCNKGFTGTYCH---ENINDCESNPCRNGGTCIDGVNSYKC- 653
Query: 1077 ACENGYWVNEDGTACE-DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCED 1135
C +G+ +G CE ++++C+ G C + F C DC G++ G +C
Sbjct: 654 ICSDGW----EGAYCETNINDCSQNPCHNGGTCRDLVNDFYC-DCKNGWK----GKTCHS 704
Query: 1136 VDECEDPQSSCLGGECKNTVGSYQCLCPQGFQLANGTVCEDV-NECMGEEHCAPHGECLN 1194
D D + GG C + +++C+CP G++ GT C N C G C+
Sbjct: 705 RDSQCDEATCNNGGTCYDEGDAFKCMCPGGWE---GTTCNIARNSSCLPNPCHNGGTCVV 761
Query: 1195 SHGSFFCLCAPGFVSAEGGTSCQDVDECATTDPCVG-GHCVNTEGSFNCLCETGFQPSPE 1253
+ SF C+C G+ EG Q+ ++C+ PC G CV+ + + C C GF
Sbjct: 762 NGESFTCVCKEGW---EGPICAQNTNDCSP-HPCYNSGTCVDGDNWYRCECAPGFA---- 813
Query: 1254 SGEC-VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMA---------------- 1296
+C ++I+EC+ P C + YRCV C PG A
Sbjct: 814 GPDCRININECQS--SPCAFGATCVDEINGYRCV--CPPGHSGAKCQEVSGRPCITMGSV 869
Query: 1297 -PNGDCIDID----ECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVDVNECEL 1351
P+G D D +C N + S +C G CL +G PSG C+ + + +
Sbjct: 870 IPDGAKWDDDCNTCQCLNGRIACSKVWC----GPRPCLLHKGHSECPSGQSCIPILDDQC 925
Query: 1352 MLAVC-GAALCEN 1363
+ C G C +
Sbjct: 926 FVHPCTGVGECRS 938
Score = 173 bits (438), Expect = 2e-42
Identities = 197/746 (26%), Positives = 291/746 (39%), Gaps = 144/746 (19%)
Query: 933 ECEQPGVCSGGQCTNTEGSYH----CECDQGYIMVRKGHCQDINECRHPGTCPDGRCVNS 988
EC + +C G C+ GS C C G+ + C HPG C G C N
Sbjct: 228 ECNR-AICRQG-CSPKHGSCKLPGDCRCQYGWQGLYCDKC-----IPHPG-CVHGIC-NE 278
Query: 989 PGSYTCLACEEGYRGQSGSCVDVNECLTPGVCAHG-KCTNL-EGSFRCSCEQGYEVTS-- 1044
P + CL CE + GQ D+N C T C +G C+N ++CSC +GY +
Sbjct: 279 P--WQCL-CETNWGGQLCD-KDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCE 334
Query: 1045 -DEKGCQDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACE-DLDECAFPGV 1102
E C D C +R SC T F C C G+ G C ++D+C+
Sbjct: 335 IAEHACLS-DPCHNRGSCK-----ETSLGFECE-CSPGW----TGPTCSTNIDDCSPNNC 383
Query: 1103 CPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCE-DVDECEDPQSSCLGGE-CKNTVGSYQC 1160
G C + F C C P G +C+ D +ECE C+ + CKN + SY C
Sbjct: 384 SHGGTCQDLVNGFKCV-CP----PQWTGKTCQLDANECE--AKPCVNAKSCKNLIASYYC 436
Query: 1161 LCPQGFQLANGTVCEDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ-DV 1219
C G+ N + ++N+C+G+ C C + + C+C PG+ G C+ D+
Sbjct: 437 DCLPGWMGQNCDI--NINDCLGQ--CQNDASCRDLVNGYRCICPPGYA----GDHCERDI 488
Query: 1220 DECATTDPCV-GGHCVNTEGSFNCLCETGFQPSPESGEC--VDIDECEDYGDPVCGTWKC 1276
DECA+ +PC+ GGHC N F CLC TGF SG +DID CE +P +C
Sbjct: 489 DECAS-NPCLNGGHCQNEINRFQCLCPTGF-----SGNLCQLDIDYCEP--NPCQNGAQC 540
Query: 1277 ENSPGSYRCVL-------GCQPGFHMAPNGDCIDIDEC-----ANDT----------MCG 1314
N Y C C C ID C +NDT +CG
Sbjct: 541 YNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCG 600
Query: 1315 SHGFC-DNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLC 1372
HG C + G F C C++GF +G C ++N+CE G + V S+ C+C
Sbjct: 601 PHGKCKSQSGGKFTCDCNKGF----TGTYCHENINDCESNPCRNGGTCIDGV-NSYKCIC 655
Query: 1373 ASDLEE-------YDAQEGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSS 1425
+ E D + C G +++ DC +G KG C S
Sbjct: 656 SDGWEGAYCETNINDCSQNPCHNGGTCRDLVND----------FYCDCKNGWKGKT-CHS 704
Query: 1426 VLGRNTTQAECCCTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTD 1485
R++ E C G + C E A F +CP G W
Sbjct: 705 ---RDSQCDEATCNNGGT-------CYDEGDA-FKCMCP---------GGWEGTTCNIAR 744
Query: 1486 ADECVIFGPGLCPN-GRCLNTVPGYVCLCNPGFHYDASHKKCEDHDECQDLACEN-GECV 1543
C+ P C N G C+ + C+C G+ ++ ++C C N G CV
Sbjct: 745 NSSCL---PNPCHNGGTCVVNGESFTCVCKEGWEGPIC---AQNTNDCSPHPCYNSGTCV 798
Query: 1544 NTEGSFHCFCSPPLT-----LDLSQQRCMNSTSSTEDLPDHDIHMDICWKKVTNDVCSEP 1598
+ + + C C+P +++++ + + + + + +C + C E
Sbjct: 799 DGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQE- 857
Query: 1599 LRGHRTTYTECCCQDGEAWSQQCALC 1624
+ G DG W C C
Sbjct: 858 VSGRPCITMGSVIPDGAKWDDDCNTC 883
Score = 144 bits (362), Expect = 1e-33
Identities = 135/546 (24%), Positives = 202/546 (36%), Gaps = 140/546 (25%)
Query: 860 TCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NECLRDPCKGKGRCINRVGSYSCFCYPGYT 918
+C +L +GYRC+C PGY + +C D +EC +PC G C N + + C C G++
Sbjct: 463 SCRDLVNGYRCICPPGY----AGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFS 518
Query: 919 LATSGATQECQ-DINECEQPGVCSGGQCTNTEGSYHCECDQGYIMVRKGH---------C 968
CQ DI+ CE +G QC N Y C+C + Y H C
Sbjct: 519 ------GNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPC 572
Query: 969 QDINECR---------------HPGTC-PDGRCVN-SPGSYTCLACEEGYRGQSGSCVDV 1011
+ I+ C C P G+C + S G +TC C +G+ G + ++
Sbjct: 573 EVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTC-DCNKGFTG-TYCHENI 630
Query: 1012 NECLTPGVCAHGKCTNLEGSFRCSCEQGYEVTSDEKGCQDVDECASRASCPTGLCLNTEG 1071
N+C + G C + S++C C G+E E ++++C+ G C +
Sbjct: 631 NDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCET---NINDCSQNPCHNGGTCRDLVN 687
Query: 1072 SFACSACENGYWVNEDGTACEDLDECAFPGVCPSG-VCTNTAGSFSCKDCDGGYRPSPLG 1130
F C C+NG+ G C D C +G C + +F C C GG+ G
Sbjct: 688 DFYCD-CKNGW----KGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCM-CPGGWE----G 737
Query: 1131 DSCEDVDECEDPQSSCL------GGECKNTVGSYQCLCPQGFQLANGTVC-EDVNECMGE 1183
+C SSCL GG C S+ C+C +G++ G +C ++ N+C
Sbjct: 738 TTCNIARN-----SSCLPNPCHNGGTCVVNGESFTCVCKEGWE---GPICAQNTNDC-SP 788
Query: 1184 EHCAPHGECLNSHGSFFCLCAPGFVSAE-------------------------------- 1211
C G C++ + C CAPGF +
Sbjct: 789 HPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPP 848
Query: 1212 --GGTSCQDVD--ECATT-----------DPCVGGHCVNTE--------GSFNCLCETGF 1248
G CQ+V C T D C C+N G CL G
Sbjct: 849 GHSGAKCQEVSGRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGH 908
Query: 1249 QPSPESGECVDIDECEDYGDPVCGTWKCENS---PGSYRCVLGCQPGFHMAPNGDCIDID 1305
P C+ I + + + P G +C +S P +C D D
Sbjct: 909 SECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQPVKTKC------------TSDSYYQD 956
Query: 1306 ECANDT 1311
CAN T
Sbjct: 957 NCANIT 962
Score = 69.7 bits (169), Expect = 2e-11
Identities = 102/410 (24%), Positives = 156/410 (38%), Gaps = 74/410 (18%)
Query: 1420 HAPC---SSVLGRNTTQAECCCTQGASWGDACDL----CPSEDSAEFSEICPSGKGY-IP 1471
H PC + + +C C +G S G C++ C S+ + G+
Sbjct: 303 HQPCLNGGTCSNTGPDKYQCSCPEGYS-GPNCEIAEHACLSDPCHNRGSCKETSLGFECE 361
Query: 1472 VEGAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGFHYDASHKKCE-DH 1529
WT G T T+ D+C P C +G C + V G+ C+C P + + K C+ D
Sbjct: 362 CSPGWT-GPTCSTNIDDC---SPNNCSHGGTCQDLVNGFKCVCPPQW----TGKTCQLDA 413
Query: 1530 DECQDLACENGE-CVNTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPDHDIHMDICWK 1588
+EC+ C N + C N S++C C P Q C DI+++ C
Sbjct: 414 NECEAKPCVNAKSCKNLIASYYCDCLP----GWMGQNC-------------DININDCLG 456
Query: 1589 KVTNDV-CSEPLRGHRTTYTECCCQDGEAWSQQCALCPPRSSEVYAQLC-NVARIEAERE 1646
+ ND C + + G+R C C G A C E + C N + E
Sbjct: 457 QCQNDASCRDLVNGYR-----CICPPGYAGDH----CERDIDECASNPCLNGGHCQNEIN 507
Query: 1647 AGVHFRP-GYEYGPGPDDLHYSIYGP--DGAPFYNYLGPEDT-VPEPAFPNTAGHSADRT 1702
P G+ D+ Y P +GA YN PE H D
Sbjct: 508 RFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC 567
Query: 1703 PILESPLQPSELQPHYVASHPEPPAGFEGLQAEECGILNGCENGRCVRVREG-YTCDCFE 1761
+P + + +AS+ + P G + + CG +G+C G +TCDC +
Sbjct: 568 RT--TPCEVIDSCTVAMASN-DTPEGVRYISSNVCG-----PHGKCKSQSGGKFTCDCNK 619
Query: 1762 GFQLDAAHMACVDVNECDD---LNGPAVLCVHGYCENTEGSYRCHCSPGY 1808
GF H ++N+C+ NG G C + SY+C CS G+
Sbjct: 620 GFTGTYCHE---NINDCESNPCRNG-------GTCIDGVNSYKCICSDGW 659
Score = 63.9 bits (154), Expect = 1e-09
Identities = 150/670 (22%), Positives = 227/670 (33%), Gaps = 159/670 (23%)
Query: 1156 GSYQCLCPQGFQLANGTVCEDVNECMGEEHCAP-HGECLNSHGSFFCLCAPGFVSAEGGT 1214
G Y C G + + N + + C+P HG C PG + G
Sbjct: 208 GHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCK----------LPGDCRCQYGW 257
Query: 1215 SCQDVDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDID--ECEDYGDPVCG 1272
D+C CV G C + CLCET + G+ D D C + P
Sbjct: 258 QGLYCDKCIPHPGCVHGIC---NEPWQCLCETNW-----GGQLCDKDLNYCGTH-QPCLN 308
Query: 1273 TWKCENS-PGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLCD 1331
C N+ P Y+C C G+ PN + + C +D C + G C T F C C
Sbjct: 309 GGTCSNTGPDKYQC--SCPEGYS-GPNCEIAE-HACLSDP-CHNRGSCKETSLGFECECS 363
Query: 1332 QGFEISPSGWDC-VDVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPRG 1390
G+ +G C ++++C G C+++ F C+C P+
Sbjct: 364 PGW----TGPTCSTNIDDCSPNNCSHGGT-CQDLVNGFKCVCP--------------PQW 404
Query: 1391 AGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACDL 1450
G +A +C + PC A+ C AS+ CD
Sbjct: 405 TGKTCQLDAN-----------ECEA-----KPC--------VNAKSCKNLIASY--YCDC 438
Query: 1451 CPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCPN-GRCLNTVPGY 1509
P W GQ + ++C+ G C N C + V GY
Sbjct: 439 LPG----------------------W-MGQNCDININDCL----GQCQNDASCRDLVNGY 471
Query: 1510 VCLCNPGFHYDASHKKCE-DHDECQDLACENGECVNTEGSFHCFCSPPLTLDLSQQRCMN 1568
C+C PG+ D CE D DEC C NG HC ++++ +C+
Sbjct: 472 RCICPPGYAGD----HCERDIDECASNPCLNGG--------HC------QNEINRFQCLC 513
Query: 1569 STSSTEDLPDHDIHMDICWKKVTNDVCSEPLRGH-RTTYTECCCQD---GEAWSQQCALC 1624
T + +L DI D C + C + + R + C C + G+ S C
Sbjct: 514 PTGFSGNLCQLDI--DYC----EPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHC 567
Query: 1625 PPRSSEVYAQLCNVARIEAEREAGVHFRPGYEYGPGPDDLHYSIYGPDGAPFYNYLGPED 1684
EV C VA + GV + + ++ GP G G
Sbjct: 568 RTTPCEVIDS-CTVAMASNDTPEGVRY------------ISSNVCGPHGKCKSQSGGKFT 614
Query: 1685 TVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPA-GFEGLQAE----ECGI 1739
F T H + +P + V S+ + G+EG E +C
Sbjct: 615 CDCNKGFTGTYCHE-NINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCS- 672
Query: 1740 LNGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEG 1798
N C NG C + + CDC G++ H +E NG G C +
Sbjct: 673 QNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNG-------GTCYDEGD 725
Query: 1799 SYRCHCSPGY 1808
+++C C G+
Sbjct: 726 AFKCMCPGGW 735
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/94 (31%), Positives = 43/94 (45%), Gaps = 15/94 (15%)
Query: 1726 PAGFEG----LQAEECGILNGCENG-RCVRVREGYTCDCFEGFQLDAAHMACVDVNECDD 1780
P G+EG + + N C NG CV E +TC C EG++ + + N+C
Sbjct: 732 PGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWE---GPICAQNTNDCS- 787
Query: 1781 LNGPAVLCVHGYCENTEGSYRCHCSPGYVAEAGP 1814
P G C + + YRC C+PG+ AGP
Sbjct: 788 ---PHPCYNSGTCVDGDNWYRCECAPGF---AGP 815
Score = 39.3 bits (90), Expect = 0.035
Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 3/45 (6%)
Query: 403 PCLNGGRC---IGRDECWCPANSTGKFCHLPIPQPDREPPGRGSR 444
PCLNGG C I R +C CP +G C L I + P G++
Sbjct: 495 PCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQ 539
Score = 37.4 bits (85), Expect = 0.13
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 9/70 (12%)
Query: 159 PRGRLTGRNVCGGQ----CCPGWTTANSTNHCIKPVCEPPCQNR-GSCSRPQLCVCRSGF 213
PR G C C GW C + +C C + GSC P C C+ G+
Sbjct: 202 PRDDFFGHYACDQNGNKTCMEGWMGPE----CNRAICRQGCSPKHGSCKLPGDCRCQYGW 257
Query: 214 RGARCEEVIP 223
+G C++ IP
Sbjct: 258 QGLYCDKCIP 267
Score = 37.0 bits (84), Expect = 0.18
Identities = 28/93 (30%), Positives = 36/93 (38%), Gaps = 16/93 (17%)
Query: 153 AAPPTPPRGRLTGRNVCG--GQC-----------CPGWTTANSTNHCIKPVCEPPCQNRG 199
A+ TP R NVCG G+C C T + I PC+N G
Sbjct: 583 ASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGG 642
Query: 200 SCS---RPQLCVCRSGFRGARCEEVIPDEEFDP 229
+C C+C G+ GA CE I D +P
Sbjct: 643 TCIDGVNSYKCICSDGWEGAYCETNINDCSQNP 675
Score = 35.4 bits (80), Expect = 0.51
Identities = 26/93 (27%), Positives = 35/93 (37%), Gaps = 26/93 (27%)
Query: 1732 LQAEECGILNGCENGR-CVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVH 1790
L A EC C N + C + Y CDC G+ +++N+C
Sbjct: 411 LDANECEA-KPCVNAKSCKNLIASYYCDCLPGWM---GQNCDININDC-----------L 455
Query: 1791 GYCENTEG------SYRCHCSPGYVAEAGPPHC 1817
G C+N YRC C PGY + HC
Sbjct: 456 GQCQNDASCRDLVNGYRCICPPGYAGD----HC 484
Score = 35.4 bits (80), Expect = 0.51
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 9/65 (13%)
Query: 1745 NGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGY-CENTEGSYRCH 1803
+G CV Y C+C GF A +++NEC + P C G C + YRC
Sbjct: 794 SGTCVDGDNWYRCECAPGF---AGPDCRININECQ--SSP---CAFGATCVDEINGYRCV 845
Query: 1804 CSPGY 1808
C PG+
Sbjct: 846 CPPGH 850
Score = 34.7 bits (78), Expect = 0.87
Identities = 28/96 (29%), Positives = 41/96 (42%), Gaps = 16/96 (16%)
Query: 1728 GFEGLQAEECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVL 1787
G++GL ++C GC +G C E + C C + + D+N C G
Sbjct: 256 GWQGLYCDKCIPHPGCVHGIC---NEPWQCLCETNW---GGQLCDKDLNYC----GTHQP 305
Query: 1788 CVH-GYCENT-EGSYRCHCSPGYVAEAGPPHCTAKE 1821
C++ G C NT Y+C C GY P+C E
Sbjct: 306 CLNGGTCSNTGPDKYQCSCPEGY----SGPNCEIAE 337
Score = 33.5 bits (75), Expect = 1.9
Identities = 20/63 (31%), Positives = 26/63 (41%), Gaps = 11/63 (17%)
Query: 173 CCPGWTTAN---STNHCIKPVCEPPCQNRGSCS---RPQLCVCRSGFRGARCEEVIPDEE 226
C PGW N + N C+ CQN SC C+C G+ G CE I +
Sbjct: 438 CLPGWMGQNCDININDCLGQ-----CQNDASCRDLVNGYRCICPPGYAGDHCERDIDECA 492
Query: 227 FDP 229
+P
Sbjct: 493 SNP 495
Score = 33.5 bits (75), Expect = 1.9
Identities = 17/51 (33%), Positives = 22/51 (43%), Gaps = 4/51 (7%)
Query: 174 CPGWTTANSTNHCIKPVCEP-PCQNRGSC---SRPQLCVCRSGFRGARCEE 220
CPG + N C P PC N G+C CVC+ G+ G C +
Sbjct: 731 CPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ 781
Score = 32.7 bits (73), Expect = 3.3
Identities = 15/34 (44%), Positives = 16/34 (47%), Gaps = 3/34 (8%)
Query: 194 PCQNRGSCSRPQL---CVCRSGFRGARCEEVIPD 224
PC NRGSC L C C G+ G C I D
Sbjct: 344 PCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD 377
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.458
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,232,493
Number of Sequences: 37866
Number of extensions: 6078827
Number of successful extensions: 49659
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 251
Number of HSP's successfully gapped in prelim test: 781
Number of HSP's that attempted gapping in prelim test: 25515
Number of HSP's gapped (non-prelim): 11372
length of query: 1821
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1704
effective length of database: 13,817,196
effective search space: 23544501984
effective search space used: 23544501984
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.