Search of human proteins with 4557649

Search of human proteins with 4557649

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
         (310 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]           613   e-176
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]   213   1e-55
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...   162   3e-40
gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo...    97   1e-20
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    74   2e-13
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         69   4e-12
gi|40254992 carbonic reductase 4 [Homo sapiens]                        69   5e-12
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    67   2e-11
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                    67   3e-11
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    63   3e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    63   4e-10
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     62   6e-10
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    61   1e-09
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     60   2e-09
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          60   3e-09
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   60   3e-09
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      59   4e-09
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       59   4e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         59   4e-09
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    59   7e-09
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform...    58   9e-09
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...    58   9e-09
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    58   9e-09
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        58   1e-08
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        57   2e-08
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...    57   3e-08
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho...    56   4e-08
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho...    56   4e-08
gi|150247226 retinol dehydrogenase 16 [Homo sapiens]                   55   6e-08
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           54   1e-07

>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
          Length = 310

 Score =  613 bits (1581), Expect = e-176
 Identities = 310/310 (100%), Positives = 310/310 (100%)

Query: 1   MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI 60
           MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
Sbjct: 1   MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI 60

Query: 61  GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL 120
           GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
Sbjct: 61  GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL 120

Query: 121 AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI 180
           AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
Sbjct: 121 AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI 180

Query: 181 LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN 240
           LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
Sbjct: 181 LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN 240

Query: 241 TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV 300
           TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
Sbjct: 241 TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV 300

Query: 301 AYLKLNTKVR 310
           AYLKLNTKVR
Sbjct: 301 AYLKLNTKVR 310


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score =  213 bits (543), Expect = 1e-55
 Identities = 119/273 (43%), Positives = 171/273 (62%), Gaps = 5/273 (1%)

Query: 18  LACLAKCVRFSRCVLLNYWKVLPKSFLR-SMGQWAVITGAGDGIGKAYSFELAKRGLNVV 76
           +A LA  + +S    L  W V  ++ +   +G+WAV+TG+ DGIGK+Y+ ELAK G+ VV
Sbjct: 19  VAYLALRISYSLFTALRVWGVGNEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVV 78

Query: 77  LISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGLEIGILVNNVGMLP 136
           LISR+ +KL+ +++EI+       + I  DF  +DIY+ IK  LAGLEIGILVNNVGM  
Sbjct: 79  LISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKIKTGLAGLEIGILVNNVGMSY 138

Query: 137 NLLPSHFLNAPD---EIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWP 193
              P +FL+ PD    I+ +I+ NI SV KMTQL+L  M  R KG ILNISSG  + P P
Sbjct: 139 EY-PEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPVP 197

Query: 194 LYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVK 253
           L ++YSA+K FV  FS+ L EEY++K V +Q + PY V+T + K     +   + + FVK
Sbjct: 198 LLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIRKPTLDKPSPETFVK 257

Query: 254 ESLNYVTIGGETCGCLAHEILAGFLSLIPAWAF 286
            ++  V +   T G L H ++   +S +P+W +
Sbjct: 258 SAIKTVGLQSRTNGYLIHALMGSIISNLPSWIY 290


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score =  162 bits (411), Expect = 3e-40
 Identities = 98/253 (38%), Positives = 148/253 (58%), Gaps = 7/253 (2%)

Query: 44  LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKII 103
           ++  G+WAV++GA DGIGKAY+ ELA RGLN++LISR  EKL+ +A +I  T      II
Sbjct: 63  IKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII 122

Query: 104 QADFTKD-DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLN-APDEIQSLIHCNITSV 161
            ADF+   +IY  I+E L   ++GILVNNVG+     P +F   + D++  +I+ NI + 
Sbjct: 123 VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPY-PQYFTQLSEDKLWDIINVNIAAA 181

Query: 162 VKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEV 221
             M  ++L  M  R+KG I+ ISSG    P P  + +SASKA++  FS+ALQ EY +K +
Sbjct: 182 SLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGI 241

Query: 222 IIQVLTPYAVSTAMTKYLN----TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGF 277
            +Q L P+ V+T+MT   N     + +  +   +   +++ + I   T G  +H I   F
Sbjct: 242 FVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLF 301

Query: 278 LSLIPAWAFYSGA 290
              +P W +  GA
Sbjct: 302 AQYMPEWLWVWGA 314


>gi|226371733 hydroxysteroid dehydrogenase like 1 isoform b [Homo
           sapiens]
          Length = 275

 Score = 97.4 bits (241), Expect = 1e-20
 Identities = 70/251 (27%), Positives = 113/251 (45%), Gaps = 58/251 (23%)

Query: 44  LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKII 103
           ++  G+WAV++GA DGIGKAY+ ELA RGL                         ++ +I
Sbjct: 63  IKQYGRWAVVSGATDGIGKAYAEELASRGL-------------------------NIILI 97

Query: 104 QADFTKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163
             +  K   +  + E                             D++  +I+ NI +   
Sbjct: 98  SRNEEKLQYFTQLSE-----------------------------DKLWDIINVNIAAASL 128

Query: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVII 223
           M  ++L  M  R+KG I+ ISSG    P P  + +SASKA++  FS+ALQ EY +K + +
Sbjct: 129 MVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFV 188

Query: 224 QVLTPYAVSTAMTKYLN----TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLS 279
           Q L P+ V+T+MT   N     + +  +   +   +++ + I   T G  +H I   F  
Sbjct: 189 QSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQ 248

Query: 280 LIPAWAFYSGA 290
            +P W +  GA
Sbjct: 249 YMPEWLWVWGA 259


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 71/256 (27%), Positives = 120/256 (46%), Gaps = 17/256 (6%)

Query: 3   DVLEQFFILTGLLVCLACLAKCVRFSRCVLLNY--WKVL-PKSFLRSMGQWAVITGAGDG 59
           ++L    +L  LL+ L  L + +R    + L +  W+   P+  L  M  W  +TGA  G
Sbjct: 4   ELLLWLLVLCALLLLLVQLLRFLRADGDLTLLWAEWQGRRPEWELTDMVVW--VTGASSG 61

Query: 60  IGKAYSFELAKRGLNVVLISRTLEKLEAI---ATEIERTTGRSVKIIQADFTKDDIYEHI 116
           IG+  +++L+K G+++VL +R + +LE +     E      + + ++  D T  D   H 
Sbjct: 62  IGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLT--DTGSHE 119

Query: 117 KEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHM 172
               A L+    I ILVNN GM    L      + D  + LI  N    V +T+ +L HM
Sbjct: 120 AATKAVLQEFGRIDILVNNGGMSQRSLCMD--TSLDVYRKLIELNYLGTVSLTKCVLPHM 177

Query: 173 ESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKA-KEVIIQVLTPYAV 231
             R++G I+ ++S + +   PL   Y ASK  +  F   L+ E      +I+  + P  V
Sbjct: 178 IERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGIIVSNICPGPV 237

Query: 232 STAMTKYLNTNVITKT 247
            + + +      +TKT
Sbjct: 238 QSNIVENSLAGEVTKT 253


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 70/284 (24%), Positives = 116/284 (40%), Gaps = 15/284 (5%)

Query: 30  CVLLNYWKV-LPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAI 88
           C L ++ K+ +PK      G+  +ITGAG GIG+  ++E AK    +VL       LE  
Sbjct: 17  CSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEET 76

Query: 89  ATEIERTTGRSVKIIQADFTKDDIYEHIKEKLAGL-EIGILVNNVGMLPNLLPSHFLNAP 147
           A + +    +    +     ++DIY   K+  A + ++ ILVNN G++       F    
Sbjct: 77  AAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVV--YTSDLFATQD 134

Query: 148 DEIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCA 207
            +I+     N+ +    T+  L  M     G I+ ++S       P    Y +SK     
Sbjct: 135 PQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVG 194

Query: 208 FSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCG 267
           F K L +E  A ++     T    +     ++NT  I   +      SL       E   
Sbjct: 195 FHKTLTDELAALQI-----TGVKTTCLCPNFVNTGFIKNPS-----TSLGPTLEPEEVVN 244

Query: 268 CLAHEILA-GFLSLIPAWAFYSGAFQRLLLTHYVAYLKLNTKVR 310
            L H IL    +  IP+   +    +R+L   ++A LK    V+
Sbjct: 245 RLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVK 288


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 55/204 (26%), Positives = 99/204 (48%), Gaps = 12/204 (5%)

Query: 47  MGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQAD 106
           M +   + G   GIG+A +  +A++G  + +I+R LE  +A A ++    G        D
Sbjct: 1   MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDL----GGDHLAFSCD 56

Query: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
             K+    + +E +++ L    +  LVN  G+  + L        +++ S +H N+   +
Sbjct: 57  VAKEHDVQNTFEELEKHLG--RVNFLVNAAGINRDGLLVR--TKTEDMVSQLHTNLLGSM 112

Query: 163 KMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVI 222
              +  ++ M  +Q G I+N+ S + L      S+YSASK  +  FS+AL +E   K++ 
Sbjct: 113 LTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIR 172

Query: 223 IQVLTPYAVSTAMTKYLNTNVITK 246
           + V+ P  V T MTK L    + K
Sbjct: 173 VNVVAPGFVHTDMTKDLKEEHLKK 196


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 67.0 bits (162), Expect = 2e-11
 Identities = 56/215 (26%), Positives = 101/215 (46%), Gaps = 9/215 (4%)

Query: 51  AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD 110
           A++T + DGIG A +  LA+ G +VV+ SR  + ++     ++   G SV        K 
Sbjct: 35  ALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGE-GLSVTGTVCHVGKA 93

Query: 111 DIYEHIKEKLAGLE--IGILVNNVGMLPNLLPSHFLNAPDEI-QSLIHCNITSVVKMTQL 167
           +  E +      L   I ILV+N  + P       ++  +E+    +  N+ +   MT+ 
Sbjct: 94  EDRERLVATAVKLHGGIDILVSNAAVNPFF--GSIMDVTEEVWDKTLDINVKAPALMTKA 151

Query: 168 ILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLT 227
           ++  ME R  G ++ +SS  A  P P +S Y+ SK  +   +K L  E   + + +  L 
Sbjct: 152 VVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLA 211

Query: 228 PYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIG 262
           P  + T+ ++ L    + K  +E +KE+L    +G
Sbjct: 212 PGLIKTSFSRML---WMDKEKEESMKETLRIRRLG 243


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 74/266 (27%), Positives = 117/266 (43%), Gaps = 50/266 (18%)

Query: 3   DVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSM-GQWAVITGAGDGIG 61
           +++ +FF++T  ++    LA             W V PK   +S+ GQ  +ITGAG G+G
Sbjct: 2   NIVVEFFVVTFKVLWAFVLAAA----------RWLVRPKE--KSVAGQVCLITGAGSGLG 49

Query: 62  KAYSFELAKRGLNVVL-----------------ISRTLEKLEAIA-------TEIERTTG 97
           + ++ E A+R   +VL                 I R LE  +A A        EI     
Sbjct: 50  RLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCN 109

Query: 98  RSVKIIQADFTK-DDIY---EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDE-IQS 152
             V     D  K +++Y   E +++++   E+ +LVNN G++      H L  PDE I+ 
Sbjct: 110 LQVFTYTCDVGKRENVYLTAERVRKEVG--EVSVLVNNAGVVSG---HHLLECPDELIER 164

Query: 153 LIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKAL 212
            +  N  +    T+  L  M     G I+ ++S + LF       Y ASK  V  F ++L
Sbjct: 165 TMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESL 224

Query: 213 QEEYKAKE---VIIQVLTPYAVSTAM 235
             E KA E   +   ++ PY V T M
Sbjct: 225 SHELKAAEKDGIKTTLVCPYLVDTGM 250


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 61/215 (28%), Positives = 97/215 (45%), Gaps = 20/215 (9%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIER---TTGRSVKIIQ 104
           G   V+TG   GIGK  + E  K+G  + L++R  +KL     EIE       + V  I 
Sbjct: 32  GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91

Query: 105 ADFTKD-----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAP-DEIQSLIHCNI 158
            D ++D     ++ +  +EKL    + +LVN  GM    +   F +      + L+  N 
Sbjct: 92  VDVSQDYNQVENVIKQAQEKLG--PVDMLVNCAGM---AVSGKFEDLEVSTFERLMSINY 146

Query: 159 TSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKA 218
              V  ++ ++  M+ R+ G I+ +SS         ++ YSASK  +   ++ALQ E K 
Sbjct: 147 LGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKP 206

Query: 219 KEVIIQVL------TPYAVSTAMTKYLNTNVITKT 247
             V I V       TP       TK L T +I++T
Sbjct: 207 YNVYITVAYPPDTDTPGFAEENRTKPLETRLISET 241


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 59/223 (26%), Positives = 98/223 (43%), Gaps = 13/223 (5%)

Query: 31  VLLNYWKVLPKSFLRSM-----GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKL 85
           ++ +Y + L K F+        G+  +ITGAG GIG+  ++E AKR   +VL       +
Sbjct: 14  IIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGV 73

Query: 86  EAIATEIERTTGRSVKIIQADFTKDDIYEHIKE-KLAGLEIGILVNNVGMLPNLLPSHFL 144
           E  A E  +    +   +     +++IY  + + K    ++ I+VNN G    + P+  L
Sbjct: 74  EETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAG---TVYPADLL 130

Query: 145 NAPD-EIQSLIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKA 203
           +  D EI      NI     +T+ +L  M  R  G I+ ++S       P    Y +SK 
Sbjct: 131 STKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKF 190

Query: 204 FVCAFSKALQEEYKA---KEVIIQVLTPYAVSTAMTKYLNTNV 243
               F + L  E +A     +    L P  V+T  TK  +T +
Sbjct: 191 AAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRL 233


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 61/205 (29%), Positives = 96/205 (46%), Gaps = 23/205 (11%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIER----TTGRSVKII 103
           GQ A++TG   GIGKA   EL + G NVV+ SR LE+L++ A E++     T    V  I
Sbjct: 18  GQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPI 77

Query: 104 QADF-TKDDIYEHIKEKLAGL-EIGILVNNVGMLPNLLPSHFLNAPDEIQS-----LIHC 156
           Q +   ++++   +K  L    +I  LVNN G         FL+  + I S     ++  
Sbjct: 78  QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGG-------GQFLSPAEHISSKGWHAVLET 130

Query: 157 NITSVVKMTQLILKHMESRQKGLILNISSGI-ALFPWPLYSMYSASKAFVCAFSKALQEE 215
           N+T    M + +         G I+NI     A FP  ++S   A++A V   +K+L  E
Sbjct: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALE 188

Query: 216 YKAKEVIIQVLTPYAV--STAMTKY 238
           +    + I  + P  +   TA+  Y
Sbjct: 189 WACSGIRINCVAPGVIYSQTAVENY 213


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 56/198 (28%), Positives = 89/198 (44%), Gaps = 22/198 (11%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEK-LEAIATEIERTTGRSVKIIQAD 106
           G+ A++TGA  GIG+A++  L  +G  V L+   LE  ++  A   E+   +    IQ D
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64

Query: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
                   D +  + +    L+  ILVNN G          +N     +  +  N+ SV+
Sbjct: 65  VADQQQLRDTFRKVVDHFGRLD--ILVNNAG----------VNNEKNWEKTLQINLVSVI 112

Query: 163 KMTQLILKHMESR---QKGLILNISSGIALFPWPLYSMYSASKAFVCAF--SKALQEEYK 217
             T L L +M  +   + G+I+N+SS   L P     +Y ASK  +  F  S AL     
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLM 172

Query: 218 AKEVIIQVLTPYAVSTAM 235
              V +  + P  V+TA+
Sbjct: 173 NSGVRLNAICPGFVNTAI 190


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 54/223 (24%), Positives = 100/223 (44%), Gaps = 23/223 (10%)

Query: 44  LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVL---------ISRTLEKLEAIATEIER 94
           LR  G+  ++TGAG G+G+AY+   A+RG  VV+         + +     + +  EI R
Sbjct: 5   LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64

Query: 95  TTGRSVKIIQADFTKDDIYEHIKEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEI 150
             G++V         D + E  K     L+    I ++VNN G+L +     F    DE 
Sbjct: 65  RGGKAVA------NYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD---RSFARISDED 115

Query: 151 QSLIH-CNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFS 209
             +IH  ++    ++T+   +HM+ ++ G I+  SS   ++     + YSA+K  +   +
Sbjct: 116 WDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLA 175

Query: 210 KALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFV 252
            +L  E +   +    + P A S      +  +++     E+V
Sbjct: 176 NSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYV 218


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 57/211 (27%), Positives = 94/211 (44%), Gaps = 8/211 (3%)

Query: 52  VITGAGDGIGKAYSFELA---KRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT 108
           +I+G   GIG   + +LA   K+   VV   R L K E +        G+++ + Q D  
Sbjct: 9   LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVC 68

Query: 109 KDDIYEHIKEKLAGLEIGILVNNVGM-LPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQL 167
            D+        + G E+ +LVNN GM L   L    L A   +Q++   N    V++ + 
Sbjct: 69  SDESVAQCLSCIQG-EVDVLVNNAGMGLVGPLEGLSLAA---MQNVFDTNFFGAVRLVKA 124

Query: 168 ILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLT 227
           +L  M+ R++G I+ ISS + L       +Y+ASK  +  F ++L  +     + I ++ 
Sbjct: 125 VLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVE 184

Query: 228 PYAVSTAMTKYLNTNVITKTADEFVKESLNY 258
           P  V T     L   V          E+L+Y
Sbjct: 185 PGPVVTEFEGKLLAQVSMAEFPGTDPETLHY 215


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 46/141 (32%), Positives = 71/141 (50%), Gaps = 7/141 (4%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
           G+  V+TGA  GIGK  + ELA+RG  V L  R +EK E +A EI+ TTG    +++   
Sbjct: 41  GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100

Query: 108 TKD--DIYEHIKEKLA-GLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
             D   I    K  LA    + +L+NN G++  + P  +    D  +  I  N      +
Sbjct: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVM--MCP--YSKTADGFEMHIGVNHLGHFLL 156

Query: 165 TQLILKHMESRQKGLILNISS 185
           T L+L+ ++      I+N+SS
Sbjct: 157 THLLLEKLKESAPSRIVNVSS 177


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 43/178 (24%), Positives = 80/178 (44%), Gaps = 1/178 (0%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
           G+  ++TGA  GIG+  ++ LAK G +VV+ +R+ E L+ + +        S   I    
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 108 TKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQL 167
                 E    +   L  G+ +  +  + N   + F +    ++  +  N  S V +T  
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 168 ILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV 225
            L  M  +  G I+ +SS      +P+ + YSASK  +  F  ++++EY    V + +
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 43/178 (24%), Positives = 80/178 (44%), Gaps = 1/178 (0%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
           G+  ++TGA  GIG+  ++ LAK G +VV+ +R+ E L+ + +        S   I    
Sbjct: 34  GKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTM 93

Query: 108 TKDDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQL 167
                 E    +   L  G+ +  +  + N   + F +    ++  +  N  S V +T  
Sbjct: 94  EDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVA 153

Query: 168 ILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV 225
            L  M  +  G I+ +SS      +P+ + YSASK  +  F  ++++EY    V + +
Sbjct: 154 ALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSI 210


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 53/207 (25%), Positives = 84/207 (40%), Gaps = 20/207 (9%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIE-RTTGRSVKIIQAD 106
           G+  ++TGA  GIGK  + ELA+RG N++L  R +EK EA A +I   T    V     D
Sbjct: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97

Query: 107 FTKDDIYEHIKEKLAGLE--IGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
                       K+   E  + IL+NN G    ++        D  +     N      +
Sbjct: 98  LASLKSIREFAAKIIEEEERVDILINNAG----VMRCPHWTTEDGFEMQFGVNHLGHFLL 153

Query: 165 TQLILKHMESRQKGLILNISS-----GIALF--------PWPLYSMYSASKAFVCAFSKA 211
           T L+L  +++     I+N+SS     G   F         +   + Y  SK  +  F+K 
Sbjct: 154 TNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKE 213

Query: 212 LQEEYKAKEVIIQVLTPYAVSTAMTKY 238
           L    +   V +  L P    T + ++
Sbjct: 214 LSRRLQGSGVTVNALHPGVARTELGRH 240


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 53/192 (27%), Positives = 90/192 (46%), Gaps = 11/192 (5%)

Query: 49  QWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT 108
           ++  ITG   G G   + +L  RGL V+    T    E  A ++   T   ++ +  D T
Sbjct: 30  KYVFITGCDSGFGNLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETVTLDVT 85

Query: 109 KDDIY----EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
           K +      + +KE +    +  LVNN G+L  +    +LN  D + +++  N+  V+++
Sbjct: 86  KMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSM-NMLKVNLIGVIQV 144

Query: 165 TQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQ 224
           T L +  +  R +G I+N+SS +    +     Y  SK  V AFS  L+ E +   V I 
Sbjct: 145 T-LSMLPLVRRARGRIVNVSSILGRVAF-FVGGYCVSKYGVEAFSDILRREIQHFGVKIS 202

Query: 225 VLTPYAVSTAMT 236
           ++ P    T MT
Sbjct: 203 IVEPGYFRTGMT 214


>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
           [Homo sapiens]
          Length = 178

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 48/172 (27%), Positives = 80/172 (46%), Gaps = 20/172 (11%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEK-LEAIATEIERTTGRSVKIIQAD 106
           G+ A++TGA  GIG+A++  L  +G  V L+   LE  ++  A   E+   +    IQ D
Sbjct: 5   GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64

Query: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
                   D +  + +    L+  ILVNN G          +N     +  +  N+ SV+
Sbjct: 65  VADQQQLRDTFRKVVDHFGRLD--ILVNNAG----------VNNEKNWEKTLQINLVSVI 112

Query: 163 KMTQLILKHMESR---QKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKA 211
             T L L +M  +   + G+I+N+SS   L P     +Y ASK  +  F+++
Sbjct: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRS 164


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 52/197 (26%), Positives = 94/197 (47%), Gaps = 11/197 (5%)

Query: 51  AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD 110
           AV+TG+  GIG A +  LA+ G +VV+ SR  + ++    +++   G SV  I     K 
Sbjct: 39  AVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQ-GEGLSVAGIVCHVGKA 97

Query: 111 DIYEHIKEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEI-QSLIHCNITSVVKMT 165
           +  E +  K   LE    +  LV + G+ P  L    L   ++I   ++  N+ S   + 
Sbjct: 98  EDREQLVAK--ALEHCGGVDFLVCSAGVNP--LVGSTLGTSEQIWDKILSVNVKSPALLL 153

Query: 166 QLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV 225
             +L +ME+R +G ++ +SS  A  P     +Y+ SK  +   ++ L  E   K++ +  
Sbjct: 154 SQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212

Query: 226 LTPYAVSTAMTKYLNTN 242
           + P  + T  +K  + N
Sbjct: 213 VVPGIIKTDFSKVFHGN 229


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 69/263 (26%), Positives = 111/263 (42%), Gaps = 26/263 (9%)

Query: 41  KSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSV 100
           K++LR+     VITGA  G+GK  +      G  +VL  R    LE +  E+  +    V
Sbjct: 47  KAYLRNAV--VVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKV 104

Query: 101 KIIQADFTKDDIYEHIKEKLAGLEI-------GILVNNVGMLPNLLPSHFLNAPDEIQSL 153
           +  +      D+ +      A  EI        ILVNN G+  +   +      D  + +
Sbjct: 105 QTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGI--SYRGTIMDTTVDVDKRV 162

Query: 154 IHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQ 213
           +  N    V +T+ +L  M  R++G I+ ISS       P  S Y+ASK    AF   L+
Sbjct: 163 METNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLR 222

Query: 214 EEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEI 273
            E +  E+ + V++P  + T      N +V   TAD      ++  T  G +   +A ++
Sbjct: 223 AEMEQYEIEVTVISPGYIHT------NLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDV 276

Query: 274 LAG---------FLSLIPAWAFY 287
           LA             L+P+ A Y
Sbjct: 277 LAAVGKKKKDVILADLLPSLAVY 299


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 56/198 (28%), Positives = 91/198 (45%), Gaps = 10/198 (5%)

Query: 40  PKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRS 99
           P SF    G+ A ITG G G+GK  +  L+  G   V+ SR ++ L+A A +I   TG  
Sbjct: 54  PNSF---QGKVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNK 110

Query: 100 VKIIQADFTKDDIYEHIKE---KLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHC 156
           V  IQ D    D+ ++      K+AG    I++NN     N +      +P+  +++   
Sbjct: 111 VHAIQCDVRDPDMVQNTVSELIKVAG-HPNIVINNAA--GNFISPTERLSPNAWKTITDI 167

Query: 157 NITSVVKMTQLILKHMESRQKG-LILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEE 215
            +     +T  I K +   QKG   L+I++  A          +++KA V A SK+L  E
Sbjct: 168 VLNGTAFVTLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAE 227

Query: 216 YKAKEVIIQVLTPYAVST 233
           +    +   V+ P  + T
Sbjct: 228 WGKYGMRFNVIQPGPIKT 245


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 53/196 (27%), Positives = 103/196 (52%), Gaps = 19/196 (9%)

Query: 51  AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKII--QADFT 108
           A++TGA  GIG A +  L ++GL VV  +RT+  +E +A E  ++ G    +I  + D +
Sbjct: 14  ALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAEC-KSAGYPGTLIPYRCDLS 72

Query: 109 KDD----IYEHIKEKLAGLEIGILVNNVGML-PNLLPSHFLNAPDEIQSLIHCNITSVVK 163
            ++    ++  I+ + +G++  I +NN G+  P+ L S    +    + + + N+ ++  
Sbjct: 73  NEEDILSMFSAIRSQHSGVD--ICINNAGLARPDTLLS---GSTSGWKDMFNVNVLALSI 127

Query: 164 MTQLILKHMESR--QKGLILNIS--SGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAK 219
            T+   + M+ R    G I+NI+  SG  + P  +   YSA+K  V A ++ L++E +  
Sbjct: 128 CTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREA 187

Query: 220 EVIIQV--LTPYAVST 233
           +  I+   ++P  V T
Sbjct: 188 QTHIRATCISPGVVET 203


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 51/192 (26%), Positives = 92/192 (47%), Gaps = 11/192 (5%)

Query: 51  AVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD 110
           AV+TG+  GIG A +  LA+ G +VV+ SR  + ++    +++   G SV  I     K 
Sbjct: 39  AVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQ-GEGLSVAGIVCHVGKA 97

Query: 111 DIYEHIKEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEI-QSLIHCNITSVVKMT 165
           +  E +  K   LE    +  LV + G+ P  L    L   ++I   ++  N+ S   + 
Sbjct: 98  EDREQLVAK--ALEHCGGVDFLVCSAGVNP--LVGSTLGTSEQIWDKILSVNVKSPALLL 153

Query: 166 QLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQV 225
             +L +ME+R +G ++ +SS  A  P     +Y+ SK  +   ++ L  E   K++ +  
Sbjct: 154 SQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNC 212

Query: 226 LTPYAVSTAMTK 237
           + P  + T  +K
Sbjct: 213 VVPGIIKTDFSK 224


>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
           sapiens]
          Length = 315

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 43/182 (23%), Positives = 86/182 (47%), Gaps = 9/182 (4%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
           G   ++TGA  G+G+  ++  A+ G ++VL + T   L+ +     +     V  I AD 
Sbjct: 29  GARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADM 88

Query: 108 TK----DDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163
                 + + +   +KL GL+  +++N++G  P         +P   + L+  N  S V+
Sbjct: 89  ASPEAPESVVQFALDKLGGLDY-LVLNHIGGAP---AGTRARSPQATRWLMQVNFVSYVQ 144

Query: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVII 223
           +T   L  + +  KG ++ +SS +   P    + YSA+K  +  F  +L+ E   ++V +
Sbjct: 145 LTSRALPSL-TDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203

Query: 224 QV 225
            +
Sbjct: 204 AI 205


>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
           sapiens]
          Length = 286

 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 43/182 (23%), Positives = 86/182 (47%), Gaps = 9/182 (4%)

Query: 48  GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADF 107
           G   ++TGA  G+G+  ++  A+ G ++VL + T   L+ +     +     V  I AD 
Sbjct: 29  GARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALLQKVVGNCRKLGAPKVFYIAADM 88

Query: 108 TK----DDIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVK 163
                 + + +   +KL GL+  +++N++G  P         +P   + L+  N  S V+
Sbjct: 89  ASPEAPESVVQFALDKLGGLDY-LVLNHIGGAP---AGTRARSPQATRWLMQVNFVSYVQ 144

Query: 164 MTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVII 223
           +T   L  + +  KG ++ +SS +   P    + YSA+K  +  F  +L+ E   ++V +
Sbjct: 145 LTSRALPSL-TDSKGSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELDVQDVNV 203

Query: 224 QV 225
            +
Sbjct: 204 AI 205


>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
          Length = 317

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 54/195 (27%), Positives = 91/195 (46%), Gaps = 17/195 (8%)

Query: 49  QWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFT 108
           ++  ITG   G GK  + +L  RGL V+    T    E  A ++   T   ++ +  D T
Sbjct: 30  KYVFITGCDSGFGKLLARQLDARGLRVLAACLT----EKGAEQLRGQTSDRLETVTLDVT 85

Query: 109 KDD----IYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKM 164
           K +      + +KE +    +  LVNN G+     P+  L   D + +++  N+  V+ +
Sbjct: 86  KTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFV-TILDVNLLGVIDV 144

Query: 165 TQLILKHMESRQKGLILNISS---GIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEV 221
           T L L  +  R +G ++N+SS    ++LF       Y  SK  V AFS +L+ E     V
Sbjct: 145 T-LSLLPLVRRARGRVVNVSSVMGRVSLFG----GGYCISKYGVEAFSDSLRRELSYFGV 199

Query: 222 IIQVLTPYAVSTAMT 236
            + ++ P    TA+T
Sbjct: 200 KVAMIEPGYFKTAVT 214


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 51/206 (24%), Positives = 92/206 (44%), Gaps = 13/206 (6%)

Query: 38  VLPKSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTG 97
           +LPK      G+  +ITGAG G+G+  + + A+ G  +VL     E  E           
Sbjct: 30  LLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGA 89

Query: 98  RSVKIIQADFT-KDDIY---EHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEI-QS 152
             V     D + K+ +Y   + +K+++   ++ IL+NN G++       FL+ PDE+ + 
Sbjct: 90  TRVHAYTCDCSQKEGVYRVADQVKKEVG--DVSILINNAGIVTG---KKFLDCPDELMEK 144

Query: 153 LIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKAL 212
               N  + +   +  L  M +   G ++ ISS   L      + Y ASK     F++++
Sbjct: 145 SFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESV 204

Query: 213 QEE---YKAKEVIIQVLTPYAVSTAM 235
             E    K K +   ++ P+ + T M
Sbjct: 205 FVETFVQKQKGIKTTIVCPFFIKTGM 230


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,138,593
Number of Sequences: 37866
Number of extensions: 395773
Number of successful extensions: 1283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 1208
Number of HSP's gapped (non-prelim): 80
length of query: 310
length of database: 18,247,518
effective HSP length: 102
effective length of query: 208
effective length of database: 14,385,186
effective search space: 2992118688
effective search space used: 2992118688
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.