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Search of human proteins with 4557543
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557543 extracellular matrix protein 2 precursor [Homo
sapiens]
(699 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 1414 0.0
gi|45505137 podocan [Homo sapiens] 143 6e-34
gi|41350214 asporin [Homo sapiens] 140 5e-33
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 134 4e-31
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 134 4e-31
gi|5901992 keratocan [Homo sapiens] 133 6e-31
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 131 2e-30
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 131 2e-30
gi|4502403 biglycan preproprotein [Homo sapiens] 131 2e-30
gi|71040111 fibromodulin precursor [Homo sapiens] 125 2e-28
gi|4505047 lumican precursor [Homo sapiens] 123 5e-28
gi|41349454 proline arginine-rich end leucine-rich repeat protei... 123 5e-28
gi|4506041 proline arginine-rich end leucine-rich repeat protein... 123 5e-28
gi|4826876 osteomodulin [Homo sapiens] 120 4e-27
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 114 3e-25
gi|226342935 podocan-like 1 isoform 3 [Homo sapiens] 113 7e-25
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 109 1e-23
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 109 1e-23
gi|20302168 toll-like receptor 8 [Homo sapiens] 107 3e-23
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 107 4e-23
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 105 2e-22
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 102 9e-22
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 102 9e-22
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 102 1e-21
gi|7706093 toll-like receptor 7 [Homo sapiens] 102 2e-21
gi|11321571 slit homolog 3 [Homo sapiens] 98 2e-20
gi|4759146 slit homolog 2 [Homo sapiens] 97 4e-20
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 97 4e-20
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 97 4e-20
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 93 1e-18
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 1414 bits (3659), Expect = 0.0
Identities = 699/699 (100%), Positives = 699/699 (100%)
Query: 1 MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTV 60
MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTV
Sbjct: 1 MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTV 60
Query: 61 FTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEP 120
FTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEP
Sbjct: 61 FTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEP 120
Query: 121 CTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGD 180
CTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGD
Sbjct: 121 CTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGD 180
Query: 181 SSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLY 240
SSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLY
Sbjct: 181 SSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLY 240
Query: 241 SEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRM 300
SEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRM
Sbjct: 241 SEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRM 300
Query: 301 PSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPD 360
PSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPD
Sbjct: 301 PSRSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPD 360
Query: 361 EAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELK 420
EAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELK
Sbjct: 361 EAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELK 420
Query: 421 VNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP 480
VNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP
Sbjct: 421 VNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP 480
Query: 481 QGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESI 540
QGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESI
Sbjct: 481 QGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESI 540
Query: 541 DLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDR 600
DLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDR
Sbjct: 541 DLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDR 600
Query: 601 VSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDS 660
VSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDS
Sbjct: 601 VSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDS 660
Query: 661 NLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK 699
NLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK
Sbjct: 661 NLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNIK 699
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 143 bits (360), Expect = 6e-34
Identities = 105/350 (30%), Positives = 170/350 (48%), Gaps = 11/350 (3%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L +P P + L L N + IP AF+ L +L L L N +T G+ + F L
Sbjct: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
L L++ NNL ++P+ LP +L L + +N ++++D L+ + L L L N L E
Sbjct: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINV 513
++PLAF+ LK L + L N +P GLP + L + +NQI I F T +
Sbjct: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
Query: 514 IVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIP- 572
+ L YN+I ++ A+ L S+DLS N+L+ +P LP+++ L + N++ +
Sbjct: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
Query: 573 GYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKA 632
G + G + L LYL+ N+L + ++ H L+ L + N L IP G+ E +
Sbjct: 517 GALVGMAQ--LRELYLTSNRLRSRALGPRAWVDLAH-LQLLDIAGNQLTEIPEGLPE--S 571
Query: 633 LHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTF 682
L +L L NNKI + D NL+ + L N + + + F
Sbjct: 572 LEYLYLQNNKISAVPANAF-----DSTPNLKGIFLRFNKLAVGSVVDSAF 616
Score = 136 bits (342), Expect = 8e-32
Identities = 112/404 (27%), Positives = 173/404 (42%), Gaps = 44/404 (10%)
Query: 331 NAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFK 390
N LT P + S++ N + I F PNL + L N + +G+ F
Sbjct: 203 NNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
Query: 391 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNL 450
+ L + N L +P LP L +L + N L+ I + S+L+ L L L+ N L
Sbjct: 263 GSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Query: 451 SEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRK 510
++ ++ F L SL YL L N +P GLP S+ L+LE N I + R
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRS 382
Query: 511 INVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIER 570
+ ++L N++ E I PLA+ + L ++ L N L VPS LP+ + L++L NQI
Sbjct: 383 LEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITG 442
Query: 571 IPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE- 629
I F LE L LS+N++ + R +F LR L L N L ++PPG+
Sbjct: 443 IGREDFA-TTYFLEELNLSYNRITSPQVHRDAF-RKLRLLRSLDLSGNRLHTLPPGLPRN 500
Query: 630 ---------------------MKALHFLRLNNNKIR------------------NILPEE 650
M L L L +N++R +I +
Sbjct: 501 VHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQ 560
Query: 651 ICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLK 694
+ E +LE+L+L+NN KI +P+ F + I L+
Sbjct: 561 LTEIPEGLPESLEYLYLQNN--KISAVPANAFDSTPNLKGIFLR 602
Score = 134 bits (337), Expect = 3e-31
Identities = 116/412 (28%), Positives = 186/412 (45%), Gaps = 16/412 (3%)
Query: 283 EEDEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYR-TISCINAMLTQIPPLT 341
EE+E EE+PV + P P P + P C+ S + C L + P
Sbjct: 89 EENEFAEEEPV---LVLSPEE---PGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDL 142
Query: 342 APQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMD 401
L L N + I E + L LE L+L N +TS G+ KAF+ L L L +
Sbjct: 143 PEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLA 202
Query: 402 GNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFK 461
N L P LP+ L + N L I + L ++ L N L++A + F
Sbjct: 203 NNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
Query: 462 PLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKI 521
++ L L N R +P+ LP ++ +L+L+NN++E+I F+ + + L+ N +
Sbjct: 263 GSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Query: 522 EENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEP 581
+ + + +LE +DLS N L VP+ LP+SL+ L L N I + V +
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIR- 381
Query: 582 GLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNN 641
LEYL L N+L + G+ ++F G L + L +N L+ +P G+ + + L + +N
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQG-LKRLHTVHLYNNALERVPSGLP--RRVRTLMILHN 438
Query: 642 KIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
+I I E+ LE L+L N I ++ F +R S+ L
Sbjct: 439 QITGIGREDFATT-----YFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDL 485
Score = 115 bits (288), Expect = 1e-25
Identities = 73/220 (33%), Positives = 111/220 (50%)
Query: 326 TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
T+ N L ++P ++ +L + N I I E F LE L+LS N ITS +
Sbjct: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
Query: 386 PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLEL 445
AF+ L+ L L++ GN L +P LP + LKV N L A+ +L + QL L L
Sbjct: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
Query: 446 EGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICF 505
N L + P A+ L L L + N+ IP+GLP S+E LYL+NN+I + F
Sbjct: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAF 590
Query: 506 NHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYN 545
+ T + I LR+NK+ + A+ ++L+ +D+ N
Sbjct: 591 DSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
Score = 93.6 bits (231), Expect = 6e-19
Identities = 67/222 (30%), Positives = 108/222 (48%), Gaps = 9/222 (4%)
Query: 477 RIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN 536
R P LP L L+NNQ+E+I + ++ + L+ N++ + A+ + N
Sbjct: 136 REFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTN 195
Query: 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADD 596
L + L+ NKL P +LP +L+ + N + +I G FG +P L +YL NKLAD
Sbjct: 196 LNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQ-KPNLRSVYLHNNKLADA 254
Query: 597 GMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEE 656
G+ F G+ ++ L L N L+ +P + AL+ L L NNK+ I P
Sbjct: 255 GLPDNMFNGS-SNVEVLILSSNFLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSEL-- 309
Query: 657 DDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
S+L L+L+NNY+ + + TF + S + L N+
Sbjct: 310 ---SSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNL 348
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/150 (29%), Positives = 72/150 (48%)
Query: 325 RTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGI 384
R++ L +PP + L++ N +A++ A G+ L L L+ N + S +
Sbjct: 481 RSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
Query: 385 GPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLE 444
GP+A+ L L L++ GN L +IP LP +LE L + N + A+ + L +
Sbjct: 541 GPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIF 600
Query: 445 LEGNNLSEANVNPLAFKPLKSLAYLRLGKN 474
L N L+ +V AF+ LK L L + N
Sbjct: 601 LRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 140 bits (352), Expect = 5e-33
Identities = 96/303 (31%), Positives = 155/303 (51%), Gaps = 11/303 (3%)
Query: 273 EDEEEEGEEGEEDEEDEEDPVRGDMFRMPSRSPLPA--PPRGTLRLPSGCSLSYRTISCI 330
+D E+ ++ ++D++D++D +F P+R P P P GC R + C
Sbjct: 32 KDMEDTDDDDDDDDDDDDDDEDNSLF--PTREPRSHFFPFDLFPMCPFGCQCYSRVVHCS 89
Query: 331 NAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFK 390
+ LT +P L+L N I I + F GL +L L L+ N +T I PKAF
Sbjct: 90 DLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFL 147
Query: 391 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNL 450
KKL RL + N L +IP LP +L EL+++EN ++ I +++ +N L LE+ N L
Sbjct: 148 TTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPL 207
Query: 451 SEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRK 510
+ P AF+ + ++ ++R+ + K +P+GLP ++ EL+L+ N+I + F ++
Sbjct: 208 DNNGIEPGAFEGV-TVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKE 266
Query: 511 INVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLP--KSLLHLVLLGNQI 568
+ + L NKI + LA N + I L NKL +PS LP K L + L N I
Sbjct: 267 LQRLGLGNNKITDIENGSLA--NIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSI 324
Query: 569 ERI 571
R+
Sbjct: 325 ARV 327
Score = 108 bits (269), Expect = 2e-23
Identities = 85/290 (29%), Positives = 138/290 (47%), Gaps = 8/290 (2%)
Query: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
L +P+ +P L + N ++ I E L L L L N L++ ++P AF K
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFLTTK 150
Query: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524
L L L N+ IP LP S+ EL + N++++I + F ++V+ + N ++ N
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584
I P A+ + I ++ KL VP LP +LL L L N+I + F + L+
Sbjct: 211 GIEPGAF-EGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKE-LQ 268
Query: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644
L L NK+ D ++ +RE+ L++N LK IP G+ E+K L + L++N I
Sbjct: 269 RLGLGNNKITDIENGSLA---NIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIA 325
Query: 645 NILPEEIC-NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
+ + C + S + L NN +K E+ TF C+ S S+ L
Sbjct: 326 RVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQL 375
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 134 bits (336), Expect = 4e-31
Identities = 83/251 (33%), Positives = 125/251 (49%), Gaps = 5/251 (1%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
P C R + C + L ++P P T L+L N I I D F L NL L L
Sbjct: 55 PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVN 114
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
N I S + P AF L KL RL + N L ++P ++P TL+EL+ +EN + + + + +
Sbjct: 115 NKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
LNQ++ +EL N L + + AF+ +K L+Y+R+ IPQGLP S+ EL+L+ N+
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
Query: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPK 556
I + + + L +N I LA N +L + L NKL VP L +
Sbjct: 233 ISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAE 290
Query: 557 -SLLHLVLLGN 566
+ +V L N
Sbjct: 291 HKYIQVVYLHN 301
Score = 117 bits (293), Expect = 4e-26
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 7/290 (2%)
Query: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
L ++P LP L + N + I + +L L L L N +S+ V+P AF PL
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLV 129
Query: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524
L L L KN+ + +P+ +P +++EL N+I ++ ++ FN ++ VI L N ++ +
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
Query: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584
I A+ + L I ++ + +P LP SL L L GN+I R+ + L
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLN-NLA 248
Query: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644
L LSFN ++ +D S H LREL LD+N L +P G+ E K + + L+NN I
Sbjct: 249 KLGLSFNSIS--AVDNGSLANTPH-LRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 305
Query: 645 NILPEEIC-NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
+ + C ++ + L +N ++ EI TF C+ S+I L
Sbjct: 306 VVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 134 bits (336), Expect = 4e-31
Identities = 83/251 (33%), Positives = 125/251 (49%), Gaps = 5/251 (1%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
P C R + C + L ++P P T L+L N I I D F L NL L L
Sbjct: 55 PFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVN 114
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
N I S + P AF L KL RL + N L ++P ++P TL+EL+ +EN + + + + +
Sbjct: 115 NKI--SKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
LNQ++ +EL N L + + AF+ +K L+Y+R+ IPQGLP S+ EL+L+ N+
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
Query: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPK 556
I + + + L +N I LA N +L + L NKL VP L +
Sbjct: 233 ISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAE 290
Query: 557 -SLLHLVLLGN 566
+ +V L N
Sbjct: 291 HKYIQVVYLHN 301
Score = 117 bits (293), Expect = 4e-26
Identities = 87/290 (30%), Positives = 142/290 (48%), Gaps = 7/290 (2%)
Query: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
L ++P LP L + N + I + +L L L L N +S+ V+P AF PL
Sbjct: 72 LDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLV 129
Query: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524
L L L KN+ + +P+ +P +++EL N+I ++ ++ FN ++ VI L N ++ +
Sbjct: 130 KLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSS 189
Query: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584
I A+ + L I ++ + +P LP SL L L GN+I R+ + L
Sbjct: 190 GIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLN-NLA 248
Query: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644
L LSFN ++ +D S H LREL LD+N L +P G+ E K + + L+NN I
Sbjct: 249 KLGLSFNSIS--AVDNGSLANTPH-LRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNIS 305
Query: 645 NILPEEIC-NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
+ + C ++ + L +N ++ EI TF C+ S+I L
Sbjct: 306 VVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQL 355
>gi|5901992 keratocan [Homo sapiens]
Length = 352
Score = 133 bits (334), Expect = 6e-31
Identities = 87/253 (34%), Positives = 139/253 (54%), Gaps = 4/253 (1%)
Query: 320 CSLSYRT-ISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNN 378
C S+ T + C N L +IP + + +I L L N I +IP++ F L ++L+KN
Sbjct: 48 CPPSFPTALYCENRGLKEIPAIPS-RIWYLYLQNNLIETIPEKPFENATQLRWINLNKNK 106
Query: 379 ITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLN 438
IT+ GI A LKKL+ L ++ N L ++PS LP +LE+L++ N + I + + S+L
Sbjct: 107 ITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLE 166
Query: 439 QLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIE 498
L L+L+ N L + FK LK+L L + KN R +P LP + +L+L+NN IE
Sbjct: 167 NLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIE 226
Query: 499 EITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSL 558
I E FN K+ + L +NK+ + + P + ++ + LS+N+L VP + L
Sbjct: 227 GIPENYFNVIPKVAFLRLNHNKLSDEGL-PSRGFDVSSILDLQLSHNQLTKVPR-ISAHL 284
Query: 559 LHLVLLGNQIERI 571
HL L N+I+ +
Sbjct: 285 QHLHLDHNKIKSV 297
Score = 122 bits (305), Expect = 1e-27
Identities = 88/305 (28%), Positives = 154/305 (50%), Gaps = 17/305 (5%)
Query: 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNP 457
L + L +IP+ +PS + L + N ++ I E+ + QL + L N ++ +
Sbjct: 56 LYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 458 LAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLR 517
A LK L +L L N+ +P LP S+E+L L N++ I + F++ + ++ L+
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQ 174
Query: 518 YNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFG 577
NK+ +N + +NL ++++ N L ++P LP + + L L N IE IP F
Sbjct: 175 NNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYF- 233
Query: 578 HMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLR 637
++ P + +L L+ NKL+D+G+ F S+ +L L HN L +P ++ LH
Sbjct: 234 NVIPKVAFLRLNHNKLSDEGLPSRGF--DVSSILDLQLSHNQLTKVPRISAHLQHLH--- 288
Query: 638 LNNNKIRNILPEEIC------NAEEDDDS---NLEHLHLENNYIKIREIPSYTFSCIRSY 688
L++NKI+++ IC AE D S +L +L L+ N IK IP +C R
Sbjct: 289 LDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHLRYLRLDGNEIK-PPIPMALMTCFRLL 347
Query: 689 SSIVL 693
++++
Sbjct: 348 QAVII 352
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 131 bits (329), Expect = 2e-30
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 9/344 (2%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L+ P + +L N + I F P L + L N ++++G+ P AF+ +
Sbjct: 134 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 193
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
+ L++ N L +P LP +LE L + N + + +LS QL L L+ N L+++
Sbjct: 194 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 253
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINV 513
++ F L SL YL L N+ +P GLP ++ L+L N+I ++ + R +
Sbjct: 254 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 313
Query: 514 IVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG 573
++L++N++ + + A L ++ L N L VP LP+ L LVL N + + G
Sbjct: 314 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL-G 372
Query: 574 YVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKAL 633
PGL L L++N+LA + +F +LR L L N L +P G+ L
Sbjct: 373 ARDLVATPGLTELNLAYNRLASARVHHRAFR-RLRALRSLDLAGNQLTRLPMGLPT--GL 429
Query: 634 HFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREI 677
L+L N++R + PE + ++ L L L +N +++ +I
Sbjct: 430 RTLQLQRNQLRMLEPEPLAGLDQ-----LRELSLAHNRLRVGDI 468
Score = 129 bits (324), Expect = 9e-30
Identities = 105/386 (27%), Positives = 173/386 (44%), Gaps = 20/386 (5%)
Query: 316 LPSGCSLSYR-----TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLE 370
LP C L T+ C L P L L N + +P + L L
Sbjct: 40 LPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLR 99
Query: 371 RLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAID 430
L+L N I+S G+ +AF+ L +L L + N L P LP +L + N + I
Sbjct: 100 TLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIF 159
Query: 431 EESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEEL 490
+ + L ++ L N LS A + P AF+ +++A L L N+ +P LP S+E L
Sbjct: 160 PLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERL 219
Query: 491 YLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV 550
+L+NN I ++ + ++ + L++N++ ++ + + +LE +DLS+N+L V
Sbjct: 220 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 279
Query: 551 PSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
P+ LP++L L L N+I ++ H GL YL L N+L G+ GA L
Sbjct: 280 PAGLPRTLAILHLGRNRIRQVEAARL-HGARGLRYLLLQHNQLGSSGLPA----GALRPL 334
Query: 611 RELFLDH---NDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHL 667
R L H N L +PP + + L L L +N + + ++ L L+L
Sbjct: 335 RGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAALGARDLVAT-----PGLTELNL 387
Query: 668 ENNYIKIREIPSYTFSCIRSYSSIVL 693
N + + F +R+ S+ L
Sbjct: 388 AYNRLASARVHHRAFRRLRALRSLDL 413
Score = 110 bits (275), Expect = 4e-24
Identities = 84/294 (28%), Positives = 131/294 (44%), Gaps = 9/294 (3%)
Query: 326 TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
T+S N L+ +PP P + L L N I+ +P A + L L L N +T SG+
Sbjct: 197 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 256
Query: 386 PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLEL 445
F L L L++ N L +P+ LP TL L + N ++ ++ L L L L
Sbjct: 257 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLL 316
Query: 446 EGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICF 505
+ N L + + A +PL+ L L L N +P LP + L L +N + +
Sbjct: 317 QHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDL 376
Query: 506 NHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLG 565
T + + L YN++ R+ A+ L S+DL+ N+L +P LP L L L
Sbjct: 377 VATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQR 436
Query: 566 NQIERIPGYVFGHMEPGLEYLYLSFNKL--ADDGMDRVSFYGAYHSLRELFLDH 617
NQ+ + ++ L L L+ N+L D G G +H L+ L + H
Sbjct: 437 NQLRMLEPEPLAGLDQ-LRELSLAHNRLRVGDIGP------GTWHELQALQVRH 483
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 131 bits (329), Expect = 2e-30
Identities = 95/344 (27%), Positives = 165/344 (47%), Gaps = 9/344 (2%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L+ P + +L N + I F P L + L N ++++G+ P AF+ +
Sbjct: 136 LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSE 195
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
+ L++ N L +P LP +LE L + N + + +LS QL L L+ N L+++
Sbjct: 196 AIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDS 255
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINV 513
++ F L SL YL L N+ +P GLP ++ L+L N+I ++ + R +
Sbjct: 256 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 315
Query: 514 IVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG 573
++L++N++ + + A L ++ L N L VP LP+ L LVL N + + G
Sbjct: 316 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAAL-G 374
Query: 574 YVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKAL 633
PGL L L++N+LA + +F +LR L L N L +P G+ L
Sbjct: 375 ARDLVATPGLTELNLAYNRLASARVHHRAFR-RLRALRSLDLAGNQLTRLPMGLPT--GL 431
Query: 634 HFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREI 677
L+L N++R + PE + ++ L L L +N +++ +I
Sbjct: 432 RTLQLQRNQLRMLEPEPLAGLDQ-----LRELSLAHNRLRVGDI 470
Score = 129 bits (324), Expect = 9e-30
Identities = 105/386 (27%), Positives = 173/386 (44%), Gaps = 20/386 (5%)
Query: 316 LPSGCSLSYR-----TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLE 370
LP C L T+ C L P L L N + +P + L L
Sbjct: 42 LPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLR 101
Query: 371 RLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAID 430
L+L N I+S G+ +AF+ L +L L + N L P LP +L + N + I
Sbjct: 102 TLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIF 161
Query: 431 EESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEEL 490
+ + L ++ L N LS A + P AF+ +++A L L N+ +P LP S+E L
Sbjct: 162 PLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERL 221
Query: 491 YLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV 550
+L+NN I ++ + ++ + L++N++ ++ + + +LE +DLS+N+L V
Sbjct: 222 HLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTV 281
Query: 551 PSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
P+ LP++L L L N+I ++ H GL YL L N+L G+ GA L
Sbjct: 282 PAGLPRTLAILHLGRNRIRQVEAARL-HGARGLRYLLLQHNQLGSSGLPA----GALRPL 336
Query: 611 RELFLDH---NDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHL 667
R L H N L +PP + + L L L +N + + ++ L L+L
Sbjct: 337 RGLHTLHLYGNGLDRVPPALP--RRLRALVLPHNHVAALGARDLVAT-----PGLTELNL 389
Query: 668 ENNYIKIREIPSYTFSCIRSYSSIVL 693
N + + F +R+ S+ L
Sbjct: 390 AYNRLASARVHHRAFRRLRALRSLDL 415
Score = 110 bits (275), Expect = 4e-24
Identities = 84/294 (28%), Positives = 131/294 (44%), Gaps = 9/294 (3%)
Query: 326 TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
T+S N L+ +PP P + L L N I+ +P A + L L L N +T SG+
Sbjct: 199 TLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD 258
Query: 386 PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLEL 445
F L L L++ N L +P+ LP TL L + N ++ ++ L L L L
Sbjct: 259 ATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLL 318
Query: 446 EGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICF 505
+ N L + + A +PL+ L L L N +P LP + L L +N + +
Sbjct: 319 QHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDL 378
Query: 506 NHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLG 565
T + + L YN++ R+ A+ L S+DL+ N+L +P LP L L L
Sbjct: 379 VATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQR 438
Query: 566 NQIERIPGYVFGHMEPGLEYLYLSFNKL--ADDGMDRVSFYGAYHSLRELFLDH 617
NQ+ + ++ L L L+ N+L D G G +H L+ L + H
Sbjct: 439 NQLRMLEPEPLAGLDQ-LRELSLAHNRLRVGDIGP------GTWHELQALQVRH 485
>gi|4502403 biglycan preproprotein [Homo sapiens]
Length = 368
Score = 131 bits (329), Expect = 2e-30
Identities = 94/285 (32%), Positives = 146/285 (51%), Gaps = 7/285 (2%)
Query: 305 PLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFN 364
P P + P GC R + C + L +P +P T L+L N I+ + + F
Sbjct: 52 PDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFK 111
Query: 365 GLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNEN 424
GL +L L L N I S I KAF L+KL +L + N+L++IP LPS+L EL++++N
Sbjct: 112 GLQHLYALVLVNNKI--SKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDN 169
Query: 425 NLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLP 484
++ + + S L + +E+ GN L + P AF LK L YLR+ + K IP+ LP
Sbjct: 170 RIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLRISEAKLTGIPKDLP 228
Query: 485 GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSY 544
++ EL+L++N+I+ I K+ + L +N+I L+++ L + L
Sbjct: 229 ETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFL--PTLRELHLDN 286
Query: 545 NKLYHVPSYLPK-SLLHLVLL-GNQIERIPGYVFGHMEPGLEYLY 587
NKL VPS LP LL +V L N I ++ F M G++ Y
Sbjct: 287 NKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGFGVKRAY 331
Score = 95.9 bits (237), Expect = 1e-19
Identities = 79/287 (27%), Positives = 135/287 (47%), Gaps = 18/287 (6%)
Query: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
L +P ++ L + N++ + ++ L L L L N +S+ ++ AF PL+
Sbjct: 81 LKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISK--IHEKAFSPLR 138
Query: 465 SLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEEN 524
L L + KN IP LP S+ EL + +N+I ++ + F+ R +N I + N +E +
Sbjct: 139 KLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENS 198
Query: 525 RIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLE 584
P A+ + L + +S KL +P LP++L L L N+I+ I +E L
Sbjct: 199 GFEPGAFDGLK-LNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAI------ELEDLLR 251
Query: 585 Y-----LYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLN 639
Y L L N++ +SF +LREL LD+N L +P G+ ++K L + L+
Sbjct: 252 YSKLYRLGLGHNQIRMIENGSLSFLP---TLRELHLDNNKLARVPSGLPDLKLLQVVYLH 308
Query: 640 NNKIRNILPEEICNAEED-DDSNLEHLHLENNYIKIREIPSYTFSCI 685
+N I + + C + + L NN + E+ TF C+
Sbjct: 309 SNNITKVGVNDFCPMGFGVKRAYYNGISLFNNPVPYWEVQPATFRCV 355
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 125 bits (313), Expect = 2e-28
Identities = 84/266 (31%), Positives = 134/266 (50%), Gaps = 8/266 (3%)
Query: 304 SPLPAPPRGTLRLPSGCSLSYRT-ISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEA 362
SP P PR + C ++ T + C N L +P ++ + N I SI +
Sbjct: 67 SPSPPDPRDCPQ-ECDCPPNFPTAMYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGV 124
Query: 363 FNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVN 422
F+ L + L N ITS +G K F L+ L RL +D NNL ++P LP +L EL ++
Sbjct: 125 FDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLD 184
Query: 423 ENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQG 482
N + + +L L L L L+ N + E + + L+SL L L N R +P G
Sbjct: 185 HNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHLRKVPDG 241
Query: 483 LPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDL 542
LP ++E+LY+E+N + + + F K+ + L +N + N +A + N +L +DL
Sbjct: 242 LPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTF-NSSSLLELDL 300
Query: 543 SYNKLYHVPSYLPKSLLHLVLLGNQI 568
SYN+L +P + +L +L L GN+I
Sbjct: 301 SYNQLQKIPP-VNTNLENLYLQGNRI 325
Score = 75.9 bits (185), Expect = 1e-13
Identities = 60/205 (29%), Positives = 101/205 (49%), Gaps = 14/205 (6%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
LT++P + L L N I+ +P+ A GL NL L L N I G + + L+
Sbjct: 167 LTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLR 223
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
L+ L++ N+L ++P LPS LE+L + NN+ + + +L+ + L N+L+
Sbjct: 224 SLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNN 283
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEI------TEICFNH 507
+ F SL L L N+ + IP + ++E LYL+ N+I E T + +
Sbjct: 284 GLASNTFNS-SSLLELDLSYNQLQKIPP-VNTNLENLYLQGNRINEFSISSFCTVVDVVN 341
Query: 508 TRKINVIVLRYNKIEENRI---APL 529
K+ V+ L N+I+ + + APL
Sbjct: 342 FSKLQVLRLDGNEIKRSAMPADAPL 366
Score = 73.2 bits (178), Expect = 8e-13
Identities = 56/188 (29%), Positives = 88/188 (46%), Gaps = 7/188 (3%)
Query: 483 LPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDL 542
+P ++ +Y +NNQI I E F++ + I L N+I +++ + +LE + L
Sbjct: 103 VPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYL 162
Query: 543 SYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVS 602
+N L +P LP+SL L L NQI R+P +E L LYL N++ + G S
Sbjct: 163 DHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLE-NLTALYLQHNEIQEVG----S 217
Query: 603 FYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNL 662
SL L L +N L+ +P G+ AL L + +N + + A + L
Sbjct: 218 SMRGLRSLILLDLSYNHLRKVPDGLP--SALEQLYMEHNNVYTVPDSYFRGAPKLLYVRL 275
Query: 663 EHLHLENN 670
H L NN
Sbjct: 276 SHNSLTNN 283
>gi|4505047 lumican precursor [Homo sapiens]
Length = 338
Score = 123 bits (309), Expect = 5e-28
Identities = 84/251 (33%), Positives = 136/251 (54%), Gaps = 5/251 (1%)
Query: 320 CSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNI 379
C SY + + + + P+ P I L L N I I ++AF + +L+ L L N +
Sbjct: 43 CPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLL 102
Query: 380 TSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQ 439
+S I + F LK+L +L+++ NNL + LP +LE+L++ N + + S L
Sbjct: 103 ENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLG--SFEGLVN 160
Query: 440 LVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEE 499
L + L+ N L E V+ AFK LKSL YL L N+ +P GLP S+ LYL+NN+I
Sbjct: 161 LTFIHLQHNRLKEDAVS-AAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISN 219
Query: 500 ITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLL 559
I + F + + L +N++ ++ I P N +L +DLSYNKL ++P+ + ++L
Sbjct: 220 IPDEYFKRFNALQYLRLSHNELADSGI-PGNSFNVSSLVELDLSYNKLKNIPT-VNENLE 277
Query: 560 HLVLLGNQIER 570
+ L NQ+E+
Sbjct: 278 NYYLEVNQLEK 288
Score = 116 bits (290), Expect = 8e-26
Identities = 88/283 (31%), Positives = 146/283 (51%), Gaps = 10/283 (3%)
Query: 412 LPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRL 471
+P ++ L + N + IDE++ ++ L L L+ N L + + F LK L L +
Sbjct: 64 VPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHI 123
Query: 472 GKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAW 531
N LP S+E+L L +N+I ++ F + I L++N+++E+ ++ A+
Sbjct: 124 NHNNLTESVGPLPKSLEDLQLTHNKITKLGS--FEGLVNLTFIHLQHNRLKEDAVSA-AF 180
Query: 532 INQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFN 591
++LE +DLS+N++ +PS LP SLL L L N+I IP F L+YL LS N
Sbjct: 181 KGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFN-ALQYLRLSHN 239
Query: 592 KLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEI 651
+LAD G+ SF + SL EL L +N LK+IP + E ++L +N + +I +
Sbjct: 240 ELADSGIPGNSFNVS--SLVELDLSYNKLKNIPT-VNENLENYYLEVNQLEKFDI--KSF 294
Query: 652 CNAEED-DDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
C S ++HL L+ N I +P + C+R + + L
Sbjct: 295 CKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTL 337
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/209 (29%), Positives = 105/209 (50%), Gaps = 13/209 (6%)
Query: 475 KFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQ 534
K + +P PG I+ LYL NNQI+ I E F + + ++L +N +E ++I +
Sbjct: 57 KLKSVPMVPPG-IKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKL 115
Query: 535 ENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLA 594
+ L+ + +++N L LPKSL L L N+I ++ + L +++L N+L
Sbjct: 116 KQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSF---EGLVNLTFIHLQHNRLK 172
Query: 595 DDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNA 654
+D + + + SL L L N + +P G+ +L L L+NNKI NI P+E
Sbjct: 173 EDAVS--AAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNI-PDEYFKR 227
Query: 655 EEDDDSNLEHLHLENNYIKIREIPSYTFS 683
+ L++L L +N + IP +F+
Sbjct: 228 ----FNALQYLRLSHNELADSGIPGNSFN 252
Score = 53.5 bits (127), Expect = 6e-07
Identities = 44/156 (28%), Positives = 72/156 (46%), Gaps = 29/156 (18%)
Query: 315 RLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDL 374
RLPSG +S + +L L N I++IPDE F L+ L L
Sbjct: 198 RLPSGLPVS---------------------LLTLYLDNNKISNIPDEYFKRFNALQYLRL 236
Query: 375 SKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESL 434
S N + SGI +F + L+ L++ N L IP+ + LE + N L+ D +S
Sbjct: 237 SHNELADSGIPGNSFN-VSSLVELDLSYNKLKNIPT-VNENLENYYLEVNQLEKFDIKSF 294
Query: 435 SDL------NQLVTLELEGNNLSEANVNPLAFKPLK 464
+ +++ L L+GN +SE ++ P ++ L+
Sbjct: 295 CKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLR 330
>gi|41349454 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 123 bits (309), Expect = 5e-28
Identities = 91/279 (32%), Positives = 137/279 (49%), Gaps = 11/279 (3%)
Query: 301 PSRSPLPAPPRGTLRLPSGCSLSY------RTISCINAMLTQIPPLTAPQITSLELTGNS 354
P+ P P PP P Y + C + L ++P + P+I L L N
Sbjct: 55 PTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPVIP-PRIHYLYLQNNF 113
Query: 355 IASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPS 414
I +P E+F L ++L N I I + + L L+ L M+ N L ++PS LP
Sbjct: 114 ITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYMEKNQLEEVPSALPR 171
Query: 415 TLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKN 474
LE+L++++N++ I S L L+ L+L+ N LS+ P F LK+L L L N
Sbjct: 172 NLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHN 231
Query: 475 KFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQ 534
R +P +P +I +LYL++N+IE I F + I L YNK+ + R P N
Sbjct: 232 ILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTD-RGLPKNSFNI 290
Query: 535 ENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG 573
NL + LS+N++ VP+ + L HL L N IE+I G
Sbjct: 291 SNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKING 328
Score = 117 bits (293), Expect = 4e-26
Identities = 84/306 (27%), Positives = 150/306 (49%), Gaps = 20/306 (6%)
Query: 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNP 457
L D NL ++P +P + L + N + + ES + L + L+ N + + ++
Sbjct: 87 LYCDSRNLRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQ 143
Query: 458 LAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLR 517
+ L L +L + KN+ +P LP ++E+L L N I I F+ + ++ L+
Sbjct: 144 RVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQ 203
Query: 518 YNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFG 577
+N++ + P + +NL ++L++N L +P +P ++ L L N+IE IP F
Sbjct: 204 HNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFK 263
Query: 578 HMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLR 637
P L ++ L++NKL D G+ + SF +L L L HN + S+P ++ L+
Sbjct: 264 SF-PNLAFIRLNYNKLTDRGLPKNSF--NISNLLVLHLSHNRISSVPAINNRLEHLY--- 317
Query: 638 LNNNKIRNILPEEIC----------NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRS 687
LNNN I I +IC +++ ++ +L +L L+ NY+K IP C R
Sbjct: 318 LNNNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYLK-PPIPLDLMMCFRL 376
Query: 688 YSSIVL 693
S+V+
Sbjct: 377 LQSVVI 382
>gi|4506041 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 123 bits (309), Expect = 5e-28
Identities = 91/279 (32%), Positives = 137/279 (49%), Gaps = 11/279 (3%)
Query: 301 PSRSPLPAPPRGTLRLPSGCSLSY------RTISCINAMLTQIPPLTAPQITSLELTGNS 354
P+ P P PP P Y + C + L ++P + P+I L L N
Sbjct: 55 PTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPVIP-PRIHYLYLQNNF 113
Query: 355 IASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPS 414
I +P E+F L ++L N I I + + L L+ L M+ N L ++PS LP
Sbjct: 114 ITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFLYMEKNQLEEVPSALPR 171
Query: 415 TLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKN 474
LE+L++++N++ I S L L+ L+L+ N LS+ P F LK+L L L N
Sbjct: 172 NLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHN 231
Query: 475 KFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQ 534
R +P +P +I +LYL++N+IE I F + I L YNK+ + R P N
Sbjct: 232 ILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTD-RGLPKNSFNI 290
Query: 535 ENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPG 573
NL + LS+N++ VP+ + L HL L N IE+I G
Sbjct: 291 SNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKING 328
Score = 117 bits (293), Expect = 4e-26
Identities = 84/306 (27%), Positives = 150/306 (49%), Gaps = 20/306 (6%)
Query: 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNP 457
L D NL ++P +P + L + N + + ES + L + L+ N + + ++
Sbjct: 87 LYCDSRNLRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQ 143
Query: 458 LAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLR 517
+ L L +L + KN+ +P LP ++E+L L N I I F+ + ++ L+
Sbjct: 144 RVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQ 203
Query: 518 YNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFG 577
+N++ + P + +NL ++L++N L +P +P ++ L L N+IE IP F
Sbjct: 204 HNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFK 263
Query: 578 HMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLR 637
P L ++ L++NKL D G+ + SF +L L L HN + S+P ++ L+
Sbjct: 264 SF-PNLAFIRLNYNKLTDRGLPKNSF--NISNLLVLHLSHNRISSVPAINNRLEHLY--- 317
Query: 638 LNNNKIRNILPEEIC----------NAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRS 687
LNNN I I +IC +++ ++ +L +L L+ NY+K IP C R
Sbjct: 318 LNNNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYLK-PPIPLDLMMCFRL 376
Query: 688 YSSIVL 693
S+V+
Sbjct: 377 LQSVVI 382
>gi|4826876 osteomodulin [Homo sapiens]
Length = 421
Score = 120 bits (301), Expect = 4e-27
Identities = 103/384 (26%), Positives = 177/384 (46%), Gaps = 19/384 (4%)
Query: 285 DEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYR---TISCINAMLTQIPPLT 341
D+E ++D G FR +P + TL S C ++ C N L IP +
Sbjct: 32 DQEPDDDYQTGFPFRQNVDYGVPFH-QYTLGCVSECFCPTNFPSSMYCDNRKLKTIPNIP 90
Query: 342 APQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMD 401
I L L N I ++ +F +L+ ++LS N I S I F L L++L+++
Sbjct: 91 M-HIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVFAKLPNLLQLHLE 149
Query: 402 GNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFK 461
NNL + P LP +LE L + N + + ++ L L L+L N L ++ + F
Sbjct: 150 HNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNYLHDSLLKDKIFA 209
Query: 462 PLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKI 521
++ L L L N+ +P GLP S+ L LENN I I E F+ K++ + + +NK+
Sbjct: 210 KMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKLPKLHTLRMSHNKL 269
Query: 522 EENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEP 581
++ P N N+ + + +NKL Y+P++L HL L N+IE++ V
Sbjct: 270 QD---IPYNIFNLPNIVELSVGHNKLKQA-FYIPRNLEHLYLQNNEIEKMNLTVMCPSID 325
Query: 582 GLEYLYLSFNKLADDGM-DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNN 640
L Y +L++ ++ + + + +S Y +F + +I G Q ++L
Sbjct: 326 PLHYHHLTYIRVDQNKLKEPISSY--------IFFCFPHIHTIYYGEQRSTNGQTIQLKT 377
Query: 641 NKIRNILPEEICNAEEDDDSNLEH 664
R P++ +E+ DD + H
Sbjct: 378 QVFRR-FPDDDDESEDHDDPDNAH 400
Score = 85.5 bits (210), Expect = 2e-16
Identities = 71/275 (25%), Positives = 119/275 (43%), Gaps = 42/275 (15%)
Query: 401 DGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAF 460
D L IP+ +P +++L + N ++A+ S + L + L N + ++ F
Sbjct: 79 DNRKLKTIPN-IPMHIQQLYLQFNEIEAVTANSFINATHLKEINLSHNKIKSQKIDYGVF 137
Query: 461 KPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNK 520
L +L L L N P LP S+E L L N+I ++ + + ++ L YN
Sbjct: 138 AKLPNLLQLHLEHNNLEEFPFPLPKSLERLLLGYNEISKLQTNAMDGLVNLTMLDLCYNY 197
Query: 521 IEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHME 580
+ ++ + + E L ++L N+L +P LP SL++L L N I IP F +
Sbjct: 198 LHDSLLKDKIFAKMEKLMQLNLCSNRLESMPPGLPSSLMYLSLENNSISSIPEKYFDKL- 256
Query: 581 PGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNN 640
P L H+LR + HN L+ IP I + + L + +
Sbjct: 257 PKL------------------------HTLR---MSHNKLQDIPYNIFNLPNIVELSVGH 289
Query: 641 NKIRNI--LPEEICNAEEDDDSNLEHLHLENNYIK 673
NK++ +P NLEHL+L+NN I+
Sbjct: 290 NKLKQAFYIPR-----------NLEHLYLQNNEIE 313
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 114 bits (285), Expect = 3e-25
Identities = 115/394 (29%), Positives = 171/394 (43%), Gaps = 70/394 (17%)
Query: 308 APPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLP 367
APP P C R + C LT +P + +L+++ N+I +P++AF P
Sbjct: 25 APP--LCAAPCSCD-GDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFP 81
Query: 368 NLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL---PSTLEELKVNEN 424
LE L L+ N++ S I PKA LK+L L + N L +PS+ S L+ L+++ N
Sbjct: 82 FLEELQLAGNDL--SFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDAN 139
Query: 425 NLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGL- 483
++ ++ E+S L QL L L+ N+L+E V+PL+ P +L L L NK IP
Sbjct: 140 HITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLP--TLQALTLALNKISSIPDFAF 197
Query: 484 --PGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESID 541
S+ L+L NN+I +++ CF+ +NLE++D
Sbjct: 198 TNLSSLVVLHLHNNKIRSLSQHCFD--------------------------GLDNLETLD 231
Query: 542 LSYNKLYHVPSYLP--KSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMD 599
L+YN L P + SL L N I IP F P L ++L N L+ G
Sbjct: 232 LNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDG-NPLLRTIHLYDNPLSFVGNS 290
Query: 600 RVSFYGAYHS--------------------LRELFLDHNDLKSIPPGI-QEMKALHFLRL 638
HS L L L + SIP + QE K L L L
Sbjct: 291 AFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
Query: 639 NNNKIRNILPEEICNAEEDDDSNLEHLHLENNYI 672
+ N IR++ C+A LE + L+ N I
Sbjct: 351 SYNNIRDLPSFNGCHA-------LEEISLQRNQI 377
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/292 (28%), Positives = 125/292 (42%), Gaps = 38/292 (13%)
Query: 302 SRSPLPAPPRGTLRLPSGCSLSYRTISCI-NAMLTQIPPLTAPQITSLELTGNSIASIPD 360
S + +P P L +L+ IS I + T + L L L N I S+
Sbjct: 164 SLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVV-----LHLHNNKIRSLSQ 218
Query: 361 EAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL---PSTLE 417
F+GL NLE LDL+ NN+ G P+A K L L L N++ IP L
Sbjct: 219 HCFDGLDNLETLDLNYNNL---GEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLR 275
Query: 418 ELKVNENNLQAIDEES---LSDLNQLV---------------TLELEGNNLSEANVNPLA 459
+ + +N L + + LSDL+ LV T+ LE L+ ++ +
Sbjct: 276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIP 335
Query: 460 ---FKPLKSLAYLRLGKNKFRIIPQGLPG--SIEELYLENNQIEEITEICFNHTRKINVI 514
+ K L L L N R +P G ++EE+ L+ NQI +I E F + ++
Sbjct: 336 NNLCQEQKMLRTLDLSYNNIRDLPS-FNGCHALEEISLQRNQIYQIKEGTFQGLISLRIL 394
Query: 515 VLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGN 566
L N I E I A+ + ++D+S+N+L P+ L L L+GN
Sbjct: 395 DLSRNLIHE--IHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
>gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]
Length = 421
Score = 113 bits (282), Expect = 7e-25
Identities = 98/367 (26%), Positives = 161/367 (43%), Gaps = 32/367 (8%)
Query: 316 LPSGCSLSYR-----TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLE 370
LP C L T+ C L P L L N + +P + L L
Sbjct: 40 LPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLR 99
Query: 371 RLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAID 430
L+L N I+S G+ +AF+ L +L L + N N + +
Sbjct: 100 TLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNK------------------NNLISKVP 141
Query: 431 EESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEEL 490
+LS QL L L+ N L+++ ++ F L SL YL L N+ +P GLP ++ L
Sbjct: 142 RGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAIL 201
Query: 491 YLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV 550
+L N+I ++ + R + ++L++N++ + + A L ++ L N L V
Sbjct: 202 HLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRV 261
Query: 551 PSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
P LP+ L LVL N + + G PGL L L++N+LA + +F +L
Sbjct: 262 PPALPRRLRALVLPHNHVAAL-GARDLVATPGLTELNLAYNRLASARVHHRAFR-RLRAL 319
Query: 611 RELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENN 670
R L L N L +P G+ L L+L N++R + PE + ++ L L L +N
Sbjct: 320 RSLDLAGNQLTRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQ-----LRELSLAHN 372
Query: 671 YIKIREI 677
+++ +I
Sbjct: 373 RLRVGDI 379
Score = 94.4 bits (233), Expect = 3e-19
Identities = 75/267 (28%), Positives = 118/267 (44%), Gaps = 9/267 (3%)
Query: 353 NSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL 412
N I+ +P A + L L L N +T SG+ F L L L++ N L +P+ L
Sbjct: 135 NLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 194
Query: 413 PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLG 472
P TL L + N ++ ++ L L L L+ N L + + A +PL+ L L L
Sbjct: 195 PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLY 254
Query: 473 KNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWI 532
N +P LP + L L +N + + T + + L YN++ R+ A+
Sbjct: 255 GNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFR 314
Query: 533 NQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNK 592
L S+DL+ N+L +P LP L L L NQ+ + ++ L L L+ N+
Sbjct: 315 RLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQ-LRELSLAHNR 373
Query: 593 L--ADDGMDRVSFYGAYHSLRELFLDH 617
L D G G +H L+ L + H
Sbjct: 374 LRVGDIGP------GTWHELQALQVRH 394
Score = 88.2 bits (217), Expect = 2e-17
Identities = 65/237 (27%), Positives = 106/237 (44%), Gaps = 5/237 (2%)
Query: 321 SLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNIT 380
SL Y +S + LT +P + L L N I + +G L L L N +
Sbjct: 176 SLEYLDLS--HNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLG 233
Query: 381 SSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQL 440
SSG+ A + L+ L L++ GN L ++P LP L L + N++ A+ L L
Sbjct: 234 SSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGL 293
Query: 441 VTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEI 500
L L N L+ A V+ AF+ L++L L L N+ +P GLP + L L+ NQ+ +
Sbjct: 294 TELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRML 353
Query: 501 TEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKS 557
++ + L +N++ I P W L+++ + + + H P S
Sbjct: 354 EPEPLAGLDQLRELSLAHNRLRVGDIGPGTW---HELQALQVRHRLVSHTVPRAPPS 407
Score = 82.8 bits (203), Expect = 1e-15
Identities = 76/299 (25%), Positives = 129/299 (43%), Gaps = 33/299 (11%)
Query: 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNP 457
++ DG +L P + + L + N LQ + LS L+ L TL L N +S +
Sbjct: 56 VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPD 115
Query: 458 LAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLR 517
AF+ L L +L + NK NN I ++ + ++ + L+
Sbjct: 116 EAFESLTQLQHLCVAHNK------------------NNLISKVPRGALSRQTQLRELYLQ 157
Query: 518 YNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFG 577
+N++ ++ + + +LE +DLS+N+L VP+ LP++L L L N+I ++
Sbjct: 158 HNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARL- 216
Query: 578 HMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDH---NDLKSIPPGIQEMKALH 634
H GL YL L N+L G+ GA LR L H N L +PP + + L
Sbjct: 217 HGARGLRYLLLQHNQLGSSGLPA----GALRPLRGLHTLHLYGNGLDRVPPALP--RRLR 270
Query: 635 FLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
L L +N + + ++ L L+L N + + F +R+ S+ L
Sbjct: 271 ALVLPHNHVAALGARDLVAT-----PGLTELNLAYNRLASARVHHRAFRRLRALRSLDL 324
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 109 bits (272), Expect = 1e-23
Identities = 86/280 (30%), Positives = 130/280 (46%), Gaps = 27/280 (9%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
PS C I C + LT IP IP++A L L
Sbjct: 32 PSVCRCDAGFIYCNDRFLTSIP-----------------TGIPEDATT-------LYLQN 67
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
N I ++GI P K L K+ R+ + N+L + P+ LP ++EL + ENN++ I +SLS
Sbjct: 68 NQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSK 126
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
+ L L L+ N++S ++ AF+ L L L +N IP GLP +IEEL L++N+
Sbjct: 127 IPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNR 186
Query: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLP- 555
I I+ + +VL N + + + + N NL + L N L P LP
Sbjct: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
Query: 556 KSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLAD 595
+L L L N I R+P F ++ L L +S N L++
Sbjct: 247 TNLRKLYLQDNHINRVPPNAFSYLRQ-LYRLDMSNNNLSN 285
Score = 89.0 bits (219), Expect = 1e-17
Identities = 64/219 (29%), Positives = 101/219 (46%), Gaps = 27/219 (12%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L + P + L L N+I +I ++ + +P LE L L N++++ I AF+
Sbjct: 95 LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
L L + N+L IP LP T+EEL++++N + I SL L L L L+GN L+
Sbjct: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGS-IEELYLENNQIEEITEICFNHTRKIN 512
+ F L +L L L +N P LPG+ + +LYL++N I
Sbjct: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHI--------------- 259
Query: 513 VIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVP 551
NR+ P A+ L +D+S N L ++P
Sbjct: 260 -----------NRVPPNAFSYLRQLYRLDMSNNNLSNLP 287
Score = 53.1 bits (126), Expect = 8e-07
Identities = 52/168 (30%), Positives = 73/168 (43%), Gaps = 29/168 (17%)
Query: 479 IPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLE 538
IP G+P LYL+NNQI N P N +E
Sbjct: 52 IPTGIPEDATTLYLQNNQIN-------------------------NAGIPSDLKNLLKVE 86
Query: 539 SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGM 598
I L +N L P+ LPK + L L N I I Y P LE L+L N ++ +
Sbjct: 87 RIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT-YDSLSKIPYLEELHLDDNSVSAVSI 145
Query: 599 DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNI 646
+ +F + + LR LFL N L +IP G+ + + LRL++N+I I
Sbjct: 146 EEGAFRDSNY-LRLLFLSRNHLSTIPWGLP--RTIEELRLDDNRISTI 190
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 25/140 (17%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L+ IP I L L N I++I + GL +L+RL L N + + G+G K F L
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225
Query: 394 KLMRLNMDGNNLIQIPSQLPST-------------------------LEELKVNENNLQA 428
L L++ N+L P LP T L L ++ NNL
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSN 285
Query: 429 IDEESLSDLNQLVTLELEGN 448
+ + DL+ + L L N
Sbjct: 286 LPQGIFDDLDNITQLILRNN 305
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 109 bits (272), Expect = 1e-23
Identities = 86/280 (30%), Positives = 130/280 (46%), Gaps = 27/280 (9%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
PS C I C + LT IP IP++A L L
Sbjct: 32 PSVCRCDAGFIYCNDRFLTSIP-----------------TGIPEDATT-------LYLQN 67
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
N I ++GI P K L K+ R+ + N+L + P+ LP ++EL + ENN++ I +SLS
Sbjct: 68 NQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSK 126
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
+ L L L+ N++S ++ AF+ L L L +N IP GLP +IEEL L++N+
Sbjct: 127 IPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNR 186
Query: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLP- 555
I I+ + +VL N + + + + N NL + L N L P LP
Sbjct: 187 ISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPG 246
Query: 556 KSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLAD 595
+L L L N I R+P F ++ L L +S N L++
Sbjct: 247 TNLRKLYLQDNHINRVPPNAFSYLRQ-LYRLDMSNNNLSN 285
Score = 89.0 bits (219), Expect = 1e-17
Identities = 64/219 (29%), Positives = 101/219 (46%), Gaps = 27/219 (12%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L + P + L L N+I +I ++ + +P LE L L N++++ I AF+
Sbjct: 95 LDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSN 154
Query: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
L L + N+L IP LP T+EEL++++N + I SL L L L L+GN L+
Sbjct: 155 YLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNH 214
Query: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGS-IEELYLENNQIEEITEICFNHTRKIN 512
+ F L +L L L +N P LPG+ + +LYL++N I
Sbjct: 215 GLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHI--------------- 259
Query: 513 VIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVP 551
NR+ P A+ L +D+S N L ++P
Sbjct: 260 -----------NRVPPNAFSYLRQLYRLDMSNNNLSNLP 287
Score = 53.1 bits (126), Expect = 8e-07
Identities = 52/168 (30%), Positives = 73/168 (43%), Gaps = 29/168 (17%)
Query: 479 IPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLE 538
IP G+P LYL+NNQI N P N +E
Sbjct: 52 IPTGIPEDATTLYLQNNQIN-------------------------NAGIPSDLKNLLKVE 86
Query: 539 SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGM 598
I L +N L P+ LPK + L L N I I Y P LE L+L N ++ +
Sbjct: 87 RIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT-YDSLSKIPYLEELHLDDNSVSAVSI 145
Query: 599 DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNI 646
+ +F + + LR LFL N L +IP G+ + + LRL++N+I I
Sbjct: 146 EEGAFRDSNY-LRLLFLSRNHLSTIPWGLP--RTIEELRLDDNRISTI 190
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/140 (27%), Positives = 57/140 (40%), Gaps = 25/140 (17%)
Query: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
L+ IP I L L N I++I + GL +L+RL L N + + G+G K F L
Sbjct: 166 LSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLV 225
Query: 394 KLMRLNMDGNNLIQIPSQLPST-------------------------LEELKVNENNLQA 428
L L++ N+L P LP T L L ++ NNL
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSN 285
Query: 429 IDEESLSDLNQLVTLELEGN 448
+ + DL+ + L L N
Sbjct: 286 LPQGIFDDLDNITQLILRNN 305
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 107 bits (268), Expect = 3e-23
Identities = 109/387 (28%), Positives = 168/387 (43%), Gaps = 48/387 (12%)
Query: 329 CINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKN----------N 378
C N L ++P +T L+L+ N I I +E+F GL NL +++L+ N
Sbjct: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG 108
Query: 379 ITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
I S+G+ AF LK L L ++ N L QIPS LP +L EL + +NN+ I +E +S
Sbjct: 109 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISR 168
Query: 437 LNQLVTLELEGN-----NLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELY 491
L L L L N + N+ F+ L +L L L N +P LP S+ +L+
Sbjct: 169 LINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF 228
Query: 492 LENNQIEEITEICFNHTRKINVIVLRYNKIE---------------ENRIAPLAWINQEN 536
L N QI+ I+E F + ++ L N I A+ N
Sbjct: 229 LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQ 288
Query: 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYV----FGHMEPGLEYLYLSFNK 592
L ++LS L + + K++ HL +L + + G + F M P LE L LSFN
Sbjct: 289 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNY 348
Query: 593 LADDGMDRVSF---YGAYHSLRELFLDHNDLKSIPPG----IQEMKALHFLRLNNNKIRN 645
+ ++ + SLR L L + + + ++ L + L N I+
Sbjct: 349 IKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ 408
Query: 646 ILPEEICNAEEDDDSNLEHLHLENNYI 672
I + N SNLE ++L N I
Sbjct: 409 IDFKLFQNF-----SNLEIIYLSENRI 430
Score = 57.8 bits (138), Expect = 3e-08
Identities = 73/283 (25%), Positives = 122/283 (43%), Gaps = 54/283 (19%)
Query: 339 PLTAPQITS----LELTGNSIASIPDEAFNGLPNLERLDLSKNNITS--SGIGPKAFKLL 392
PL PQ + L+L+ NSI I F LP++ L+LS N+ SG A +
Sbjct: 473 PLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHV 532
Query: 393 KKL----MRLNMDGNNLIQIPSQLP--------------------------STLEELKVN 422
K L RL+ D + + S L + L+ L ++
Sbjct: 533 KYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLS 592
Query: 423 ENNLQAIDEESLSDLNQLVTLELEGNNL-----SEANVNPLAFKPLKSLAYLRLGKNKFR 477
NN+ + ++ + LV L GN L + N FK LK+L L L N+ +
Sbjct: 593 HNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLK 652
Query: 478 IIPQ----GLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKI--EENRIAPLAW 531
IP LP S+ EL++ +N ++ ++ ++ LR NK+ + ++
Sbjct: 653 HIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFT- 711
Query: 532 INQENLESIDLSYNKLYHVPS-YLPK--SLLHLVLLGNQIERI 571
+L ++ LS+N++ H+PS +L + SL HL L N ++ I
Sbjct: 712 ---SSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTI 751
Score = 52.4 bits (124), Expect = 1e-06
Identities = 52/175 (29%), Positives = 83/175 (47%), Gaps = 17/175 (9%)
Query: 357 SIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQ----L 412
S+ + F+G RLD+ N+ + I FK LK L RL++ N L IP++ L
Sbjct: 609 SLVELVFSG----NRLDILWNDDDNRYIS--IFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
Query: 413 PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLG 472
P++L EL +N+N L+ + L +L L+L GN L + F SL L L
Sbjct: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF--TSSLRTLLLS 720
Query: 473 KNKFRIIPQGL---PGSIEELYLENNQIEEITEICF--NHTRKINVIVLRYNKIE 522
N+ +P G S++ L L +N ++ I + T K++++ L N E
Sbjct: 721 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 775
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 107 bits (267), Expect = 4e-23
Identities = 112/414 (27%), Positives = 180/414 (43%), Gaps = 49/414 (11%)
Query: 317 PSGCSLSYRTISCINAMLT----QIPPLTA--------------------PQITSLELTG 352
P GC + + C + L IPP T P +T +
Sbjct: 23 PMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLN 82
Query: 353 NSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPS-- 410
+ +AF GLP LE L+++ ++ + + F L L +L ++ N L +P
Sbjct: 83 TQLCQFRPDAFGGLPRLEDLEVTGSSFLN--LSTNIFSNLTSLGKLTLNFNMLEALPEGL 140
Query: 411 -QLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYL 469
Q + LE L + N LQA+ L L TL L N L A + F PL SL L
Sbjct: 141 FQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL--AQLPEELFHPLTSLQTL 198
Query: 470 RLGKNKFRIIPQGL---PGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRI 526
+L N +PQG+ GS++EL+L++N I E+ F+ + + L+ N I +
Sbjct: 199 KLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPL 258
Query: 527 APLAWINQENLESIDLSYNKLYHVPSYL---PKSLLHLVLLGNQIERIPGYVFGHMEPGL 583
+ A + NL + L +N L +P+ L L+ L L NQ+E + F H+ L
Sbjct: 259 SIFASLG--NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLS-NL 315
Query: 584 EYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGI-QEMKALHFLRLNNNK 642
L LS+N + + L +L+L N+L ++ P + Q + L L L+ N+
Sbjct: 316 RSLMLSYNAITH---LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 643 IRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQ 696
+ LPE I D + NL +L L N + +Y F+ ++ Y+ +L Q
Sbjct: 373 L-TTLPEGIF----DTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ 421
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 105 bits (261), Expect = 2e-22
Identities = 89/278 (32%), Positives = 125/278 (44%), Gaps = 27/278 (9%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
PS C I C + LT IP A IPD+A L L
Sbjct: 55 PSVCRCDNGFIYCNDRGLTSIP-----------------ADIPDDATT-------LYLQN 90
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
N I ++GI P+ K + + + N+L + P LP +L EL + +NN++ I +SL+
Sbjct: 91 NQINNAGI-PQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLAR 149
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQ 496
+ L L L+ N++S ++ AF K L L L +N IP GLP ++EEL L++N+
Sbjct: 150 IPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNR 209
Query: 497 IEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPK 556
I I F + +VL N + RIA + +NL + L N L P LP
Sbjct: 210 ISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPS 269
Query: 557 S-LLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKL 593
+ L L L N I IP M LE L LS N L
Sbjct: 270 AHLQKLYLQDNAISHIPYNTLAKMRE-LERLDLSNNNL 306
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/215 (27%), Positives = 89/215 (41%), Gaps = 34/215 (15%)
Query: 479 IPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLE 538
IP +P LYL+NNQI N P + N++
Sbjct: 75 IPADIPDDATTLYLQNNQIN-------------------------NAGIPQDLKTKVNVQ 109
Query: 539 SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGM 598
I L N L P LP+SL L L N + I + P LE L+L N ++ +
Sbjct: 110 VIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARI-PLLEKLHLDDNSVSTVSI 168
Query: 599 DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDD 658
+ +F + L+ LFL N L SIP G+ L LRL++N+I I
Sbjct: 169 EEDAFADS-KQLKLLFLSRNHLSSIPSGLPH--TLEELRLDDNRISTIPLHAFKGL---- 221
Query: 659 DSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
++L L L+ N + + I TFS +++ + + L
Sbjct: 222 -NSLRRLVLDGNLLANQRIADDTFSRLQNLTELSL 255
Score = 37.0 bits (84), Expect = 0.062
Identities = 25/66 (37%), Positives = 34/66 (51%), Gaps = 4/66 (6%)
Query: 338 PPLTAPQ--ITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITS--SGIGPKAFKLLK 393
PPL P + L L N+I+ IP + LERLDLS NN+T+ G+ L +
Sbjct: 263 PPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQ 322
Query: 394 KLMRLN 399
L+R N
Sbjct: 323 LLLRNN 328
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 102 bits (255), Expect = 9e-22
Identities = 146/543 (26%), Positives = 220/543 (40%), Gaps = 131/543 (24%)
Query: 239 LYSEGDSRGGDRKQRPGEER-RLAHQQQRQGREEEEDEEE-EGEEGEEDEEDEEDPVRGD 296
L E DS+ D K +ER + A G+E +E E + +G++ ++ ++D G
Sbjct: 5 LGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAAQPGV 64
Query: 297 MFRMPSRSPLPAPPRGTLRLPSGCSLSYRTISC--------------INAMLTQIPPLTA 342
F + + P P GT + S + C I+ + + I LT
Sbjct: 65 AFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELT- 123
Query: 343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDG 402
Q+T L L N + S+P E L NL L LS+N++TS P + LKKL L++
Sbjct: 124 -QLTELYLYSNKLQSLPAEV-GCLVNLMTLALSENSLTSL---PDSLDNLKKLRMLDLRH 178
Query: 403 NNLIQIPSQLP-------------------------STLEELKVNENNLQAIDEESLSDL 437
N L +IPS + S L L + EN ++ + E + +L
Sbjct: 179 NKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAE-IGEL 237
Query: 438 NQLVTLELEGNNLS---------------EANVNPLAFKP-----LKSLAYLRLGKNKFR 477
L+TL++ N L + N L P L SL+ L L N+
Sbjct: 238 CNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLS 297
Query: 478 IIPQGLP--GSIEELYLENNQIEEITEICFNHTRKINVIVLRYN---------------- 519
IP+ L ++EEL LENN I + E + K+N + L N
Sbjct: 298 AIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTI 357
Query: 520 ---KIEENRIAPLAW---INQENLESIDLSYNKLYHVPSYLPK--SLLHLVLLGNQIERI 571
+E NRI + + + L +++ N+L +P S++ L L NQ+ +I
Sbjct: 358 YSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKI 417
Query: 572 PGYVFGHMEPGLEYLYLSFN--KLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE 629
P V G + LE L LS N K G+ G LREL L+ N L+S+P I
Sbjct: 418 PEDVSGLVS--LEVLILSNNLLKKLPHGL------GNLRKLRELDLEENKLESLPNEIAY 469
Query: 630 MKALHFLRLNNNKIRNI----------------------LPEEICNAEEDDDSNLEHLHL 667
+K L L L NN++ + LPEEI E NLE L+L
Sbjct: 470 LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLE-----NLEELYL 524
Query: 668 ENN 670
+N
Sbjct: 525 NDN 527
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 102 bits (255), Expect = 9e-22
Identities = 82/287 (28%), Positives = 135/287 (47%), Gaps = 9/287 (3%)
Query: 309 PPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPN 368
P G L S +S S ++ +L P + + S+ S+P G+P
Sbjct: 9 PSHGAFFLKSWLIISLGLYSQVSKLLA-CPSVCRCDRNFVYCNERSLTSVP----LGIPE 63
Query: 369 -LERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQ 427
+ L L N I ++G P ++ + + + GN L + P LP + L + ENN+Q
Sbjct: 64 GVTVLYLHNNQINNAGF-PAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQ 122
Query: 428 AIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSI 487
I +L+ L +L L L+ N++S V AF+ SL L L KN +P GLP +
Sbjct: 123 TISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDL 182
Query: 488 EELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKL 547
+EL ++ N+I I+++ F + + +++ N + IA + + L+ + N L
Sbjct: 183 QELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL 242
Query: 548 YHVPSYLPKS-LLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKL 593
H P LP + L+ L L NQI IP F ++ LE L +S N+L
Sbjct: 243 SHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRK-LERLDISNNQL 288
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/205 (28%), Positives = 89/205 (43%), Gaps = 34/205 (16%)
Query: 479 IPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLE 538
+P G+P + LYL NNQI N P N +++
Sbjct: 57 VPLGIPEGVTVLYLHNNQIN-------------------------NAGFPAELHNVQSVH 91
Query: 539 SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGM 598
++ L N+L P LPK++ L L N I+ I + LE L+L N ++ G+
Sbjct: 92 TVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLK-LEELHLDDNSISTVGV 150
Query: 599 DRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDD 658
+ +F A SL+ LFL N L S+P G+ L LR++ N+I I N
Sbjct: 151 EDGAFREAI-SLKLLFLSKNHLSSVPVGLP--VDLQELRVDENRIAVISDMAFQNL---- 203
Query: 659 DSNLEHLHLENNYIKIREIPSYTFS 683
++LE L ++ N + + I TFS
Sbjct: 204 -TSLERLIVDGNLLTNKGIAEGTFS 227
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 102 bits (254), Expect = 1e-21
Identities = 114/423 (26%), Positives = 187/423 (44%), Gaps = 56/423 (13%)
Query: 305 PLPAPPRGTLRLPSGCSLSYRTIS-CINAMLTQIPPLTAP-QITSLELTGNSIASIPDEA 362
P P PP C +R + C + +I L P +T + L G + ++
Sbjct: 18 PFPCPP--------ACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQS 69
Query: 363 FNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPS---TLEEL 419
F+G+ L+RL +S ++I S + P F L KL L + N + +P L LE+L
Sbjct: 70 FSGMTVLQRLMISDSHI--SAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQL 127
Query: 420 KVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRII 479
++ N L+ ID+ L L L L N L + F L++L L L N +
Sbjct: 128 FLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPAS--LFTNLENLKLLDLSGNNLTHL 185
Query: 480 PQGLPGS---IEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN 536
P+GL G+ +E L L +N++ + N + + N I IAP A+ N
Sbjct: 186 PKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS--IAPGAFDRLPN 243
Query: 537 LESIDLSYNKLYHVPSYL---PKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKL 593
L S+ LS N L +PS L +L L L N + +PG +FG M GL+ L+L+ +L
Sbjct: 244 LSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEM-GGLQELWLNRTQL 302
Query: 594 ------ADDGMDRVSF-------------YGAYHSLRE---LFLDHNDLKSIPPG-IQEM 630
A + R+ + GA+ L E L L N L ++P G ++ +
Sbjct: 303 RTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGL 362
Query: 631 KALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSS 690
L + L N++R LP + + S+LE + L++N ++ +P F + +
Sbjct: 363 GKLRQVSLRRNRLR-ALPRALFR----NLSSLESVQLDHN--QLETLPGDVFGALPRLTE 415
Query: 691 IVL 693
++L
Sbjct: 416 VLL 418
Score = 66.6 bits (161), Expect = 7e-11
Identities = 80/287 (27%), Positives = 128/287 (44%), Gaps = 26/287 (9%)
Query: 345 ITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNN 404
+ L L N + +P F L NL+ LDLS NN+T G KL RL + N
Sbjct: 148 LQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG--LLGAQAKLERLLLHSNR 205
Query: 405 LIQIPSQLPST---LEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFK 461
L+ + S L ++ L EL+ + N++++I + L L +L L N+L A + F
Sbjct: 206 LVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHL--AFLPSALFL 263
Query: 462 PLKSLAYLRLGKNKFRIIPQ---GLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRY 518
+L L L +N +P G G ++EL+L Q+ + F N+ LRY
Sbjct: 264 HSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFR-----NLSRLRY 318
Query: 519 NKIE-ENRIAPL---AWINQENLESIDLSYNKLYHVPSYLPK---SLLHLVLLGNQIERI 571
+ R++ L A+ L+ + L N L +P L + L + L N++ +
Sbjct: 319 LGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRAL 378
Query: 572 PGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHN 618
P +F ++ LE + L N+L D +GA L E+ L HN
Sbjct: 379 PRALFRNLS-SLESVQLDHNQLETLPGD---VFGALPRLTEVLLGHN 421
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 102 bits (253), Expect = 2e-21
Identities = 114/402 (28%), Positives = 177/402 (44%), Gaps = 41/402 (10%)
Query: 305 PLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFN 364
P P TL +P ++ + C + LT+IP T+L LT N I I +F+
Sbjct: 31 PKTLPCDVTLDVPK----NHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFH 86
Query: 365 GLPNLERLDL----------SKNN--ITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL 412
L +L +D SKNN I I P++F L L L +DGN L++IP L
Sbjct: 87 RLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL 146
Query: 413 PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEAN-------VNPLAFKPLKS 465
P +L+ L + NN+ +I +E+L++L + L L G N N + AF L
Sbjct: 147 PPSLQLLSLEANNIFSIRKENLTELANIEILYL-GQNCYYRNPCYVSYSIEKDAFLNLTK 205
Query: 466 LAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENR 525
L L L N +P LP ++ ELYL NN I +I E FN+ ++ ++ L N
Sbjct: 206 LKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGN-CPRCY 264
Query: 526 IAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEY 585
AP +N + + N + L L L N ++ +P F ++ L+
Sbjct: 265 NAPFPCAPCKNNSPLQIPVNAFDAL-----TELKVLRLHSNSLQHVPPRWFKNINK-LQE 318
Query: 586 LYLSFNKLADDGMDRVSFYGAYHSLRELFLDHN-DLK------SIPPGIQEMKALHFLRL 638
L LS N LA + D F SL +L L N +L+ ++ +K+L LR+
Sbjct: 319 LDLSQNFLAKEIGD-AKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRI 377
Query: 639 NNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSY 680
+ + + + + NLE L L N+IKI + +
Sbjct: 378 RGYVFKELKSFNL--SPLHNLQNLEVLDLGTNFIKIANLSMF 417
Score = 65.9 bits (159), Expect = 1e-10
Identities = 80/295 (27%), Positives = 129/295 (43%), Gaps = 57/295 (19%)
Query: 348 LELTGNSIA-SIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNN-- 404
L L+GN I+ ++ F L L LD S N + + AF+ L KL L++ N+
Sbjct: 522 LNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDL--LHSTAFEELHKLEVLDISSNSHY 579
Query: 405 --------LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA--- 453
++ L L++L +N+N++ + ++ L TLE GN+L
Sbjct: 580 FQSEGITHMLNFTKNL-KVLQKLMMNDNDISSSTSRTMES-ESLRTLEFRGNHLDVLWRE 637
Query: 454 --NVNPLAFKPLKSLAYLRLGKNKFRIIPQG----LPGSIEELYLENNQIEEITEICFNH 507
N FK L L L + KN +P G +P +++ L L N ++ +
Sbjct: 638 GDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFS------ 691
Query: 508 TRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYL---PKSLLHLVLL 564
+K+ + +NLE++DLS+N+L VP L +SL +L+L
Sbjct: 692 WKKLQCL--------------------KNLETLDLSHNQLTTVPERLSNCSRSLKNLILK 731
Query: 565 GNQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSF-YGAYHSLRELFLDHN 618
NQI + Y F L YL LS NK+ + + SF ++L+ L L HN
Sbjct: 732 NNQIRSLTKY-FLQDAFQLRYLDLSSNKI--QMIQKTSFPENVLNNLKMLLLHHN 783
Score = 50.1 bits (118), Expect = 7e-06
Identities = 105/476 (22%), Positives = 173/476 (36%), Gaps = 117/476 (24%)
Query: 329 CINAMLTQIPPLTAPQITSLE---LTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
C N QIP +T L+ L NS+ +P F + L+ LDLS+N +
Sbjct: 273 CKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGD 332
Query: 386 PKAFKLLKKLMRLNMDGNNLIQIP------SQLPSTLEELKVNE------NNLQAIDEES 433
K L L++L++ N +Q+ SQ S+L+ LK+ L++ +
Sbjct: 333 AKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSP 392
Query: 434 LSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLE 493
L +L L L+L N + AN++ FK K L + L NK I P G +
Sbjct: 393 LHNLQNLEVLDLGTNFIKIANLS--MFKQFKRLKVIDLSVNK--ISPSGDSSEVGFCSNA 448
Query: 494 NNQIEEITEICFNHTRKINVIVLRYNKIE-----ENRIAPLAWINQENL---ESIDLSYN 545
+E RY+K +N+ A +N+ +++DLS N
Sbjct: 449 RTSVESYEPQVLEQLH-----YFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKN 503
Query: 546 KLYHVPSYLPKSLLHLVLL---GNQIER-IPGYVFGHMEPGLEYLYLSFNKLADDGMDRV 601
++ V S + L L L GN I + + G F +P E YL F+ D +
Sbjct: 504 SIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEF---QPLAELRYLDFSNNRLDLLHST 560
Query: 602 SFY--------------------GAYHSL---------RELFLDHNDLKSIPPGIQEMKA 632
+F G H L ++L ++ ND+ S E ++
Sbjct: 561 AFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESES 620
Query: 633 LHFLRLNNNKI---------------RNILPEEICNAEEDDDS------------NLEHL 665
L L N + +N+L E + ++ S NL++L
Sbjct: 621 LRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNL 680
Query: 666 HLENNYIK----------------------IREIPSYTFSCIRSYSSIVLKPQNIK 699
L N +K + +P +C RS +++LK I+
Sbjct: 681 SLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIR 736
Score = 47.0 bits (110), Expect = 6e-05
Identities = 62/245 (25%), Positives = 102/245 (41%), Gaps = 45/245 (18%)
Query: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNN--ITSSGIG-----PKAFKLLKKLM 396
++ L+ + N + + AF L LE LD+S N+ S GI K K+L+KLM
Sbjct: 543 ELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLM 602
Query: 397 RLNMD--------------------GNNL-----------IQIPSQLPSTLEELKVNENN 425
+ D GN+L +Q+ L LEEL +++N+
Sbjct: 603 MNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLK-LEELDISKNS 661
Query: 426 LQAIDEESLSDLN-QLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLP 484
L + + L L L N L + L + LK+L L L N+ +P+ L
Sbjct: 662 LSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKL--QCLKNLETLDLSHNQLTTVPERLS 719
Query: 485 G---SIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESID 541
S++ L L+NNQI +T+ ++ + L NKI+ + NL+ +
Sbjct: 720 NCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLL 779
Query: 542 LSYNK 546
L +N+
Sbjct: 780 LHHNR 784
Score = 37.7 bits (86), Expect = 0.036
Identities = 33/137 (24%), Positives = 54/137 (39%), Gaps = 29/137 (21%)
Query: 343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDG 402
P + +L L N + S + L NLE LDLS N +T+
Sbjct: 675 PNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTT--------------------- 713
Query: 403 NNLIQIPSQLPS---TLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLA 459
+P +L + +L+ L + N ++++ + L D QL L+L N +
Sbjct: 714 -----VPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFP 768
Query: 460 FKPLKSLAYLRLGKNKF 476
L +L L L N+F
Sbjct: 769 ENVLNNLKMLLLHHNRF 785
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 98.2 bits (243), Expect = 2e-20
Identities = 111/407 (27%), Positives = 181/407 (44%), Gaps = 37/407 (9%)
Query: 307 PAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGL 366
P+ ++ PS C+ S + C L +IP I + L NSI +IP AF
Sbjct: 271 PSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQY 330
Query: 367 PNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPS---TLEELKVNE 423
L+R+D+SKN I S I P AF+ LK L L + GN + +I L +L+ L +N
Sbjct: 331 KKLKRIDISKNQI--SDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNA 388
Query: 424 NNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGL 483
N + + + DL L L L N L ++ F PL+S+ L L +N F + L
Sbjct: 389 NKINCLRVNTFQDLQNLNLLSLYDNKLQ--TISKGLFAPLQSIQTLHLAQNPF-VCDCHL 445
Query: 484 PGSIEELYLENNQIEEITEICFNHTRKIN--VIVLRYNKIE-------ENRIAPLAWINQ 534
+ YL++N IE C + R N + ++ K +R + +++
Sbjct: 446 KWLAD--YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDL 503
Query: 535 ENLES-------IDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLY 587
E +D S KL +PS+LP+ + L L N++ + P L +
Sbjct: 504 VCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKIN 563
Query: 588 LSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGI-QEMKALHFLRLNNNKIRNI 646
LS NK+ + + +F GA S++EL L N L+++ + + + L L L +N I +
Sbjct: 564 LSNNKIKE--VREGAFDGA-ASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCV 620
Query: 647 LPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
+ S++ L L +N +I I F+ + S S+I L
Sbjct: 621 SNDTFAGL-----SSVRLLSLYDN--RITTITPGAFTTLVSLSTINL 660
Score = 75.5 bits (184), Expect = 2e-13
Identities = 89/371 (23%), Positives = 145/371 (39%), Gaps = 61/371 (16%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEA-FNGLPNLERLDLS 375
P C + C N L +IP +T L L N ++ + F LPNL +++LS
Sbjct: 506 PEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLS 565
Query: 376 KNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL---PSTLEELKVNENNLQAIDEE 432
N I G AF + L + GN L + ++ S L+ L + N + + +
Sbjct: 566 NNKIKEVREG--AFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623
Query: 433 SLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKF---------------R 477
+ + L+ + L L N ++ + P AF L SL+ + L N F R
Sbjct: 624 TFAGLSSVRLLSLYDNRIT--TITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKR 681
Query: 478 IIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENL 537
I G P + +L+ I+++ I N+ +++P +
Sbjct: 682 RIVSGNPRCQKPFFLKEIPIQDVA---------IQDFTCDGNEESSCQLSPRCPEQCTCM 732
Query: 538 ESIDLSYNK-LYHVPSYLPKSLLHLVLLGNQIERIP-----------------------G 573
E++ NK L +P +PK + L L GN + +P
Sbjct: 733 ETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 792
Query: 574 YVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPG-IQEMKA 632
Y F +M L L LS+N+L V + SLR L L ND+ S+P G ++ +
Sbjct: 793 YTFSNMS-HLSTLILSYNRLR---CIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTS 848
Query: 633 LHFLRLNNNKI 643
L L L N +
Sbjct: 849 LSHLALGTNPL 859
Score = 73.2 bits (178), Expect = 8e-13
Identities = 103/410 (25%), Positives = 161/410 (39%), Gaps = 57/410 (13%)
Query: 304 SPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAF 363
S L PP + P+ C+ S ++ C L +P L+L N+I I F
Sbjct: 24 SVLSGPP--AVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDF 81
Query: 364 NGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPS---QLPSTLEELK 420
GL NL L L N + S I AF+ LK+L RL ++ N L +P Q L L
Sbjct: 82 AGLKNLRVLHLEDNQV--SVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLD 139
Query: 421 VNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP 480
++EN +Q I ++ + + L+L+ N++S + AF+ L+ L
Sbjct: 140 LSENQIQGIPRKAFRGITDVKNLQLDNNHIS--CIEDGAFRALRDL-------------- 183
Query: 481 QGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESI 540
E L L NN I I FNH KI + L N + + LAW++ +
Sbjct: 184 -------EILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCD--CHLAWLSDWLRQRR 234
Query: 541 DLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEP--------GLEYLYLSFNK 592
+ L P +L + V + P H EP N
Sbjct: 235 TVGQFTLCMAPVHLRGFNVADVQKKEYVCPAP-----HSEPPSCNANSISCPSPCTCSNN 289
Query: 593 LAD---DGMDRVSFYGAYHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKIRNILP 648
+ D G+ + + E+ L+ N +K+IP G + K L + ++ N+I +I P
Sbjct: 290 IVDCRGKGLMEIP-ANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAP 348
Query: 649 EEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
+ + +L L L N KI EI F + S ++L I
Sbjct: 349 DAFQGLK-----SLTSLVLYGN--KITEIAKGLFDGLVSLQLLLLNANKI 391
Score = 66.6 bits (161), Expect = 7e-11
Identities = 69/263 (26%), Positives = 116/263 (44%), Gaps = 18/263 (6%)
Query: 345 ITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN- 403
+ +L L N I + ++ F GL ++ L L N IT+ I P AF L L +N+ N
Sbjct: 607 LKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT--ITPGAFTTLVSLSTINLLSNP 664
Query: 404 -NLIQIPSQLPSTLEELKVNENNLQA-----IDEESLSDLNQLVTLELEGNNLSEANVNP 457
N + L L + ++ N + + E + D+ + +GN S ++P
Sbjct: 665 FNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDV-AIQDFTCDGNEESSCQLSP 723
Query: 458 LAFKPLKSL-AYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVL 516
+ + +R R +P+G+P + ELYLE N + + + R + +I L
Sbjct: 724 RCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSALRHLTLIDL 782
Query: 517 RYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYL---PKSLLHLVLLGNQIERIPG 573
N I + + + N +L ++ LSYN+L +P + +SL L L GN I +P
Sbjct: 783 SNNSI--SMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPE 840
Query: 574 YVFGHMEPGLEYLYLSFNKLADD 596
F + L +L L N L D
Sbjct: 841 GSFNDL-TSLSHLALGTNPLHCD 862
Score = 53.9 bits (128), Expect = 5e-07
Identities = 46/160 (28%), Positives = 71/160 (44%), Gaps = 26/160 (16%)
Query: 315 RLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDL 374
R P C+ + C N L +P +T L L GN + ++P E + L +L +DL
Sbjct: 724 RCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRE-LSALRHLTLIDL 782
Query: 375 SKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESL 434
S N+I+ M N +N+ S L L ++ N L+ I +
Sbjct: 783 SNNSIS---------------MLTNYTFSNM--------SHLSTLILSYNRLRCIPVHAF 819
Query: 435 SDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKN 474
+ L L L L GN++S +V +F L SL++L LG N
Sbjct: 820 NGLRSLRVLTLHGNDIS--SVPEGSFNDLTSLSHLALGTN 857
Score = 48.5 bits (114), Expect = 2e-05
Identities = 76/335 (22%), Positives = 144/335 (42%), Gaps = 49/335 (14%)
Query: 398 LNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESL-SDLNQLVTLELEGNNLSEANVN 456
++ L++IPS LP + +L++N+N + ++ + L L + L N + E V
Sbjct: 516 VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKE--VR 573
Query: 457 PLAFKPLKSLAYLRLGKNKFRIIP----QGLPGSIEELYLENNQIEEITEICFNHTRKIN 512
AF S+ L L N+ + +GL G ++ L L +N I ++ F +
Sbjct: 574 EGAFDGAASVQELMLTGNQLETVHGRVFRGLSG-LKTLMLRSNLIGCVSNDTFAGLSSVR 632
Query: 513 VIVLRYNKIEENRIAPLAWINQENLESIDL---SYNKLYHVPSYLPKSLL-HLVLLGNQI 568
++ L N+I I P A+ +L +I+L +N H+ ++L K L ++ GN
Sbjct: 633 LLSLYDNRI--TTITPGAFTTLVSLSTINLLSNPFNCNCHL-AWLGKWLRKRRIVSGNPR 689
Query: 569 ERIPGYVF---------------GHMEPGLEY---------LYLSFNKLADDGMDRVSFY 604
+ P ++ G+ E + + + ++ G+ R
Sbjct: 690 CQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGL-RALPR 748
Query: 605 GAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEH 664
G + EL+L+ N L ++P + ++ L + L+NN I + SN+ H
Sbjct: 749 GMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTF--------SNMSH 800
Query: 665 LH-LENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
L L +Y ++R IP + F+ +RS + L +I
Sbjct: 801 LSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
Score = 34.3 bits (77), Expect = 0.40
Identities = 36/102 (35%), Positives = 48/102 (47%), Gaps = 8/102 (7%)
Query: 306 LPAPPR--GTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAF 363
L A PR LR + LS +IS MLT +++L L+ N + IP AF
Sbjct: 764 LTAVPRELSALRHLTLIDLSNNSIS----MLTNYTFSNMSHLSTLILSYNRLRCIPVHAF 819
Query: 364 NGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNL 405
NGL +L L L N+I+S G +F L L L + N L
Sbjct: 820 NGLRSLRVLTLHGNDISSVPEG--SFNDLTSLSHLALGTNPL 859
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 97.4 bits (241), Expect = 4e-20
Identities = 97/364 (26%), Positives = 159/364 (43%), Gaps = 38/364 (10%)
Query: 308 APPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLP 367
AP L P+ C+ S + C LT+IP IT + L N+I IP AF+
Sbjct: 265 APSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYK 324
Query: 368 NLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPS---TLEELKVNEN 424
L R+DLS N I S + P AF+ L+ L L + GN + ++P L +L+ L +N N
Sbjct: 325 KLRRIDLSNNQI--SELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNAN 382
Query: 425 NLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLP 484
+ + ++ DL+ L L L N L + F PL+++ + L +N F I L
Sbjct: 383 KINCLRVDAFQDLHNLNLLSLYDNKLQ--TIAKGTFSPLRAIQTMHLAQNPF-ICDCHLK 439
Query: 485 GSIEELYLENNQIEEITEICFNHTRKINVIVLRY----------------------NKIE 522
+ YL N IE C + R N + + +K+
Sbjct: 440 WLAD--YLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLS 497
Query: 523 ENRIAPLAWINQENLE--SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHME 580
+ A LA + E ++D S KL +P ++P+ L L N+ +
Sbjct: 498 GDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKL 557
Query: 581 PGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGI-QEMKALHFLRLN 639
P L + S NK+ D ++ +F GA + E+ L N L+++ + + +++L L L
Sbjct: 558 PQLRKINFSNNKITD--IEEGAFEGA-SGVNEILLTSNRLENVQHKMFKGLESLKTLMLR 614
Query: 640 NNKI 643
+N+I
Sbjct: 615 SNRI 618
Score = 86.7 bits (213), Expect = 7e-17
Identities = 104/400 (26%), Positives = 163/400 (40%), Gaps = 62/400 (15%)
Query: 317 PSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSK 376
P+ CS S T+ C L +P L+L GN+I I F GL +L L L +
Sbjct: 29 PAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLME 88
Query: 377 NNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQL---PSTLEELKVNENNLQAIDEES 433
N I++ G AF+ LK+L RL ++ N+L P L + L L ++EN +QAI ++
Sbjct: 89 NKISTIERG--AFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKA 146
Query: 434 LSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLE 493
+ L+L+ N +S + AF+ L+ L E L L
Sbjct: 147 FRGAVDIKNLQLDYNQIS--CIEDGAFRALRDL---------------------EVLTLN 183
Query: 494 NNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSY 553
NN I ++ FNH K+ L N + + LAW++ + + PS+
Sbjct: 184 NNNITRLSVASFNHMPKLRTFRLHSNNLYCD--CHLAWLSDWLRQRPRVGLYTQCMGPSH 241
Query: 554 LPKSLLHLVLLGNQIERIPGYVF---GH---MEPGLEYLY-----LSFNKLAD---DGMD 599
L G+ + + F GH M P L+ N + D G+
Sbjct: 242 ---------LRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLT 292
Query: 600 RVSFYGAYHSLRELFLDHNDLKSIPPG-IQEMKALHFLRLNNNKIRNILPEEICNAEEDD 658
+ ++ E+ L+ N +K IPPG K L + L+NN+I + P+
Sbjct: 293 EIP-TNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLR--- 348
Query: 659 DSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
+L L L N KI E+P F + S ++L I
Sbjct: 349 --SLNSLVLYGN--KITELPKSLFEGLFSLQLLLLNANKI 384
Score = 64.7 bits (156), Expect = 3e-10
Identities = 70/265 (26%), Positives = 125/265 (47%), Gaps = 21/265 (7%)
Query: 345 ITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN- 403
+ +L L N I + +++F GL ++ L L N IT+ + P AF L L LN+ N
Sbjct: 608 LKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITT--VAPGAFDTLHSLSTLNLLANP 665
Query: 404 -NLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLN-QLVTLEL----EGNNLSEANVNP 457
N + L L + ++ N + L ++ Q V ++ +GN+ + + +P
Sbjct: 666 FNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGND--DNSCSP 723
Query: 458 LAFKPLKSLAY---LRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVI 514
L+ P + +R +++P+G+P + ELYL+ NQ + + N+ + + +I
Sbjct: 724 LSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY-KHLTLI 782
Query: 515 VLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYL---PKSLLHLVLLGNQIERI 571
L N+I + ++ ++ N L ++ LSYN+L +P KSL L L GN I +
Sbjct: 783 DLSNNRI--STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV 840
Query: 572 PGYVFGHMEPGLEYLYLSFNKLADD 596
P F + L +L + N L D
Sbjct: 841 PEGAFNDLS-ALSHLAIGANPLYCD 864
Score = 51.6 bits (122), Expect = 2e-06
Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 6/139 (4%)
Query: 315 RLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDL 374
R P+ C+ + C N L +P +T L L GN +P E N +L +DL
Sbjct: 726 RCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSN-YKHLTLIDL 784
Query: 375 SKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELK---VNENNLQAIDE 431
S N I S + ++F + +L+ L + N L IP + L+ L+ ++ N++ + E
Sbjct: 785 SNNRI--STLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842
Query: 432 ESLSDLNQLVTLELEGNNL 450
+ +DL+ L L + N L
Sbjct: 843 GAFNDLSALSHLAIGANPL 861
Score = 48.5 bits (114), Expect = 2e-05
Identities = 89/412 (21%), Positives = 147/412 (35%), Gaps = 83/412 (20%)
Query: 303 RSPLPAPPRGTLRLPSGCSLSYRTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEA 362
RS L L P C T+ C N L +IP L L N +
Sbjct: 493 RSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE--- 549
Query: 363 FNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPS---QLPSTLEEL 419
++GI FK L +L ++N N + I + S + E+
Sbjct: 550 ------------------ATGI----FKKLPQLRKINFSNNKITDIEEGAFEGASGVNEI 587
Query: 420 KVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRII 479
+ N L+ + + L L TL L N ++ +G + F
Sbjct: 588 LLTSNRLENVQHKMFKGLESLKTLMLRSNRIT------------------CVGNDSFI-- 627
Query: 480 PQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLES 539
GL S+ L L +NQI + F+ ++ + L N N LAW+ + +
Sbjct: 628 --GL-SSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCN--CYLAWLGEWLRKK 682
Query: 540 IDLSYNKLYHVPSYLPKSLLHLVLL-------GNQ------IERIPGYVFGHMEPGLEYL 586
++ N P +L + + V + GN + R P L+ +
Sbjct: 683 RIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTEC-----TCLDTV 737
Query: 587 YLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNI 646
NK G+ +V G + EL+LD N +P + K L + L+NN+I +
Sbjct: 738 VRCSNK----GL-KVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTL 792
Query: 647 LPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
+ N + L L +Y ++R IP TF ++S + L +I
Sbjct: 793 SNQSFSNM-------TQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDI 837
Score = 34.3 bits (77), Expect = 0.40
Identities = 52/181 (28%), Positives = 81/181 (44%), Gaps = 20/181 (11%)
Query: 524 NRIAPLAWINQENLE--SIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEP 581
N++AP A Q + ++D L VP +P++ L L GN I RI F +
Sbjct: 21 NKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLR- 79
Query: 582 GLEYLYLSFNKLADDGMDRVSFYGAYHSLRE---LFLDHNDLKSIPPGIQEMKA-LHFLR 637
L L L NK++ ++R GA+ L+E L L+ N L+ P + A L+ L
Sbjct: 80 HLRVLQLMENKIST--IER----GAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLD 133
Query: 638 LNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQN 697
L+ N+I+ I P + D +++L L+ N I I F +R + L N
Sbjct: 134 LSENQIQAI-PRKAFRGAVD----IKNLQLDYNQISC--IEDGAFRALRDLEVLTLNNNN 186
Query: 698 I 698
I
Sbjct: 187 I 187
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 97.4 bits (241), Expect = 4e-20
Identities = 108/361 (29%), Positives = 167/361 (46%), Gaps = 28/361 (7%)
Query: 323 SYRTISCINAMLTQIPPL--TAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNIT 380
S R + N L IP L + IT L L GN I I E +LE LDLS NNI+
Sbjct: 99 SLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS 158
Query: 381 SSGIGPKAFKLLKKLMRLNMDGNNLIQIP----SQLPSTLEELKVNENNLQAIDEESLSD 436
AF L +L L ++ N + + L +TL LK+N N + AI + +
Sbjct: 159 EL---QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-MFK 213
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGL---PGSIEELYLE 493
L QL LEL N + NV+ L F+ L +L L++ +N + G ++E L L+
Sbjct: 214 LPQLQHLELNRNKIK--NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 271
Query: 494 NNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV--P 551
+N + EIT+ + + L N I NRI+P AW + L +DL++N L +
Sbjct: 272 HNNLTEITKGWLYGLLMLQELHLSQNAI--NRISPDAWEFCQKLSELDLTFNHLSRLDDS 329
Query: 552 SYLPKSLLHLVLLG-NQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
S+L SLL+ + +G N++ I F + L+ L L N+++ D + L
Sbjct: 330 SFLGLSLLNTLHIGNNRVSYIADCAFRGLS-SLKTLDLKNNEISWTIEDMNGAFSGLDKL 388
Query: 611 RELFLDHNDLKSI-PPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLEN 669
R L L N ++SI + AL L L++N I ++ ++ L+ LHL
Sbjct: 389 RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNT 443
Query: 670 N 670
+
Sbjct: 444 S 444
Score = 57.4 bits (137), Expect = 4e-08
Identities = 48/182 (26%), Positives = 91/182 (50%), Gaps = 13/182 (7%)
Query: 469 LRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEE-NRIA 527
L + + +P+ LP + L L +N++ I +H + + + L N++E +
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLG 117
Query: 528 PLAWINQENLESIDLSYNKLYHV-PSYLPK--SLLHLVLLGNQIERIPGYVFGHMEPGLE 584
P++ N+ + L+ N++ + P +L + SL L L N I + F ++ L+
Sbjct: 118 PVS----ANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ--LK 170
Query: 585 YLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIR 644
YLYL+ N++ M+ F ++L L L+ N + +IPP + ++ L L LN NKI+
Sbjct: 171 YLYLNSNRVTS--MEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIK 228
Query: 645 NI 646
N+
Sbjct: 229 NV 230
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/63 (42%), Positives = 39/63 (61%), Gaps = 2/63 (3%)
Query: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
++ L L GN I SI +AF GL LE LDLS N I S + AF +KKL +L+++ +
Sbjct: 387 KLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMS--LQGNAFSQMKKLQQLHLNTS 444
Query: 404 NLI 406
+L+
Sbjct: 445 SLL 447
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 97.4 bits (241), Expect = 4e-20
Identities = 108/361 (29%), Positives = 167/361 (46%), Gaps = 28/361 (7%)
Query: 323 SYRTISCINAMLTQIPPL--TAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNIT 380
S R + N L IP L + IT L L GN I I E +LE LDLS NNI+
Sbjct: 39 SLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS 98
Query: 381 SSGIGPKAFKLLKKLMRLNMDGNNLIQIP----SQLPSTLEELKVNENNLQAIDEESLSD 436
AF L +L L ++ N + + L +TL LK+N N + AI + +
Sbjct: 99 EL---QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-MFK 153
Query: 437 LNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGL---PGSIEELYLE 493
L QL LEL N + NV+ L F+ L +L L++ +N + G ++E L L+
Sbjct: 154 LPQLQHLELNRNKIK--NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211
Query: 494 NNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHV--P 551
+N + EIT+ + + L N I NRI+P AW + L +DL++N L +
Sbjct: 212 HNNLTEITKGWLYGLLMLQELHLSQNAI--NRISPDAWEFCQKLSELDLTFNHLSRLDDS 269
Query: 552 SYLPKSLLHLVLLG-NQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSL 610
S+L SLL+ + +G N++ I F + L+ L L N+++ D + L
Sbjct: 270 SFLGLSLLNTLHIGNNRVSYIADCAFRGLS-SLKTLDLKNNEISWTIEDMNGAFSGLDKL 328
Query: 611 RELFLDHNDLKSI-PPGIQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLEN 669
R L L N ++SI + AL L L++N I ++ ++ L+ LHL
Sbjct: 329 RRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKK-----LQQLHLNT 383
Query: 670 N 670
+
Sbjct: 384 S 384
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/63 (42%), Positives = 39/63 (61%), Gaps = 2/63 (3%)
Query: 344 QITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGN 403
++ L L GN I SI +AF GL LE LDLS N I S + AF +KKL +L+++ +
Sbjct: 327 KLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMS--LQGNAFSQMKKLQQLHLNTS 384
Query: 404 NLI 406
+L+
Sbjct: 385 SLL 387
Score = 39.7 bits (91), Expect = 0.010
Identities = 48/170 (28%), Positives = 82/170 (48%), Gaps = 22/170 (12%)
Query: 535 ENLESIDLSYNKLYHVPSYLPKS--LLHLVLLGNQI-ERIPGYVFGHMEPGLEYLYLSFN 591
++L + L+ N+L +P+ P S + L L GN+I E +P ++ LE L LS N
Sbjct: 38 QSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQS--LETLDLSSN 95
Query: 592 KLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKA--LHFLRLNNNKIRNILPE 649
+++ + +F L+ L+L+ N + S+ PG + A L L+LN N+I I P+
Sbjct: 96 NISEL---QTAFPAL--QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK 150
Query: 650 EICNAEEDDDSNLEHL-HLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
L L HLE N KI+ + TF + + S+ ++ +
Sbjct: 151 MF---------KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGV 191
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 92.8 bits (229), Expect = 1e-18
Identities = 103/353 (29%), Positives = 161/353 (45%), Gaps = 49/353 (13%)
Query: 372 LDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKV---NENNLQA 428
LDLS NN+T + P F L+ L L + GN+L IP Q S L LK+ N L
Sbjct: 71 LDLSMNNLTE--LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGG 128
Query: 429 IDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIP----QGLP 484
I E+L +L L +L L+ N +S V +F+ L SL +L L N IP LP
Sbjct: 129 IPAEALWELPSLQSLRLDANLIS--LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLP 186
Query: 485 GSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSY 544
+++ + L N+I I + F + + V+ L N+I+ + ++ NLE++DL+Y
Sbjct: 187 -ALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQ--HLGTHSFEGLHNLETLDLNY 243
Query: 545 NKLYHVPSYLPKSLLHLVLLG---NQIERIPGYVFGHMEPGLEYLYLSFNKLADDGMDRV 601
NKL P + ++L L LG N I+ IP F P L+ ++ N + G
Sbjct: 244 NKLQEFPVAI-RTLGRLQELGFHNNNIKAIPEKAF-MGNPLLQTIHFYDNPIQFVGRSAF 301
Query: 602 SFYGAYH--------------------SLRELFLDHNDLKSIPPGI-QEMKALHFLRLNN 640
+ H SL L L ++ +P G+ Q++ L L L++
Sbjct: 302 QYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 361
Query: 641 NKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
N+I + C LE + L++N +I EI + TFS + S ++ L
Sbjct: 362 NQIEELPSLHRC-------QKLEEIGLQHN--RIWEIGADTFSQLSSLQALDL 405
Score = 79.3 bits (194), Expect = 1e-14
Identities = 94/366 (25%), Positives = 159/366 (43%), Gaps = 48/366 (13%)
Query: 343 PQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDG 402
P + SL L N I+ +P+ +F GL +L L L N +T I +A L L + +
Sbjct: 138 PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPALQAMTLAL 195
Query: 403 NNLIQIPS---QLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLA 459
N + IP Q ++L L ++ N +Q + S L+ L TL+L N L E P+A
Sbjct: 196 NRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF---PVA 252
Query: 460 FKPLKSLAYLRLGKNKFRIIPQ----GLPGSIEELYLENNQIEEITEICFNHTRKINVIV 515
+ L L L N + IP+ G P ++ ++ +N I+ + F + K++ +
Sbjct: 253 IRTLGRLQELGFHNNNIKAIPEKAFMGNP-LLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 311
Query: 516 LRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIP 572
L ++ L +LE + L+ + +PS + + L L +L NQIE +P
Sbjct: 312 LN-GAMDIQEFPDLK--GTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 368
Query: 573 GYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSI-PPGIQEMK 631
H LE + L N++ + G D + SL+ L L N ++SI P +
Sbjct: 369 SL---HRCQKLEEIGLQHNRIWEIGADT---FSQLSSLQALDLSWNAIRSIHPEAFSTLH 422
Query: 632 ALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNY-------------IKIREIP 678
+L L L +N++ + + L HL L+ N ++I E+P
Sbjct: 423 SLVKLDLTDNQLTTLPLAGL--------GGLMHLKLKGNLALSQAFSKDSFPKLRILEVP 474
Query: 679 SYTFSC 684
Y + C
Sbjct: 475 -YAYQC 479
Score = 65.1 bits (157), Expect = 2e-10
Identities = 71/242 (29%), Positives = 114/242 (47%), Gaps = 21/242 (8%)
Query: 405 LIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLK 464
L +P L L ++ NNL + L L L L GN+LS ++ AF L
Sbjct: 57 LSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS--HIPGQAFSGLY 114
Query: 465 SLAYLRLGKNKFRIIPQ----GLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNK 520
SL L L N+ IP LP S++ L L+ N I + E F + + L N
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELP-SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNA 173
Query: 521 IEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLL---GNQIERIPGYVFG 577
+ E I A N L+++ L+ N++ H+P Y ++L LV+L N+I+ + + F
Sbjct: 174 LTE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
Query: 578 HMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPP----GIQEMKAL 633
+ LE L L++NKL + + + G L+EL +N++K+IP G ++ +
Sbjct: 232 GLH-NLETLDLNYNKLQEFPV-AIRTLG---RLQELGFHNNNIKAIPEKAFMGNPLLQTI 286
Query: 634 HF 635
HF
Sbjct: 287 HF 288
Score = 62.0 bits (149), Expect = 2e-09
Identities = 64/228 (28%), Positives = 100/228 (43%), Gaps = 31/228 (13%)
Query: 341 TAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNM 400
T ++ L N+I +IP++AF G P L+ + N I +G AF+ L KL L++
Sbjct: 255 TLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI--QFVGRSAFQYLPKLHTLSL 312
Query: 401 DGNNLIQIPSQLPST--LEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPL 458
+G IQ L T LE L + ++ + L +L LEL N + E
Sbjct: 313 NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEE------ 366
Query: 459 AFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRY 518
L SL + +EE+ L++N+I EI F+ + + L +
Sbjct: 367 ----LPSLHRCQ---------------KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 407
Query: 519 NKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGN 566
N I I P A+ +L +DL+ N+L +P L+HL L GN
Sbjct: 408 NAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,957,035
Number of Sequences: 37866
Number of extensions: 1600911
Number of successful extensions: 37454
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 876
Number of HSP's successfully gapped in prelim test: 650
Number of HSP's that attempted gapping in prelim test: 12616
Number of HSP's gapped (non-prelim): 11220
length of query: 699
length of database: 18,247,518
effective HSP length: 109
effective length of query: 590
effective length of database: 14,120,124
effective search space: 8330873160
effective search space used: 8330873160
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.