BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4557469 adaptor-related protein complex 2, beta 1 subunit isoform b [Homo sapiens] (937 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 1853 0.0 gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 1843 0.0 gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 1566 0.0 gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 1565 0.0 gi|166197671 adaptor-related protein complex 4, beta 1 subunit [... 301 1e-81 gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 280 6e-75 gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H... 270 5e-72 gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 96 2e-19 gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 94 6e-19 gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 91 5e-18 gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 88 3e-17 gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 79 2e-14 gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 79 2e-14 gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 79 2e-14 gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 76 1e-13 gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 74 5e-13 gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 65 2e-10 gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi... 62 2e-09 gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 60 7e-09 gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 54 5e-07 gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 50 8e-06 gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo ... 39 0.017 gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 36 0.19 gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 36 0.19 gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 36 0.19 gi|156104874 envoplakin [Homo sapiens] 35 0.25 gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens] 35 0.33 gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens] 35 0.33 gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens] 35 0.43 gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens] 34 0.56 >gi|4557469 adaptor-related protein complex 2, beta 1 subunit isoform b [Homo sapiens] Length = 937 Score = 1853 bits (4800), Expect = 0.0 Identities = 937/937 (100%), Positives = 937/937 (100%) Query: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT Sbjct: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 Query: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL Sbjct: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660 Query: 661 DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA 720 DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA Sbjct: 661 DSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKA 720 Query: 721 KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ 780 KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ Sbjct: 721 KGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQ 780 Query: 781 SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLAT 840 SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLAT Sbjct: 781 SIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLAT 840 Query: 841 WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL 900 WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL Sbjct: 841 WKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWIL 900 Query: 901 AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 937 AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN Sbjct: 901 AELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 937 >gi|71773106 adaptor-related protein complex 2, beta 1 subunit isoform a [Homo sapiens] Length = 951 Score = 1843 bits (4775), Expect = 0.0 Identities = 937/951 (98%), Positives = 937/951 (98%), Gaps = 14/951 (1%) Query: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT Sbjct: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI Sbjct: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE Sbjct: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV Sbjct: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV Sbjct: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST Sbjct: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 Query: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL Sbjct: 601 DAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGL 660 Query: 661 DSL--------------VGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 706 DSL VGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG Sbjct: 661 DSLLGSDLGGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGG 720 Query: 707 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 766 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP Sbjct: 721 YVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP 780 Query: 767 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 826 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF Sbjct: 781 STPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLF 840 Query: 827 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 886 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM Sbjct: 841 VEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDM 900 Query: 887 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 937 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN Sbjct: 901 LYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN 951 >gi|22027653 adaptor-related protein complex 1 beta 1 subunit isoform b [Homo sapiens] Length = 942 Score = 1566 bits (4055), Expect = 0.0 Identities = 792/944 (83%), Positives = 870/944 (92%), Gaps = 9/944 (0%) Query: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT Sbjct: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60 Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180 Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240 Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY LLKKLAPPLVTLLS EPE+QY Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300 Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420 Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540 Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG G+ K LP S+ Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600 Query: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657 ++ +SP T A EQP VIP+QGDLLGDLLNLDLGPPV+ P + SS+QMGAVDLLG Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660 Query: 658 GGLDSLV-GQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLP 716 GGLDSL+ G +F+ + P P+ A + SGL+DLF+L++G+G G YVAPKAVWLP Sbjct: 661 GGLDSLIGGTNFV--APPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLP 718 Query: 717 AVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPL 776 A+KAKGLEISGTFT + G I M++ TNKALQ MTDFAIQFN+NSFG+ P+TPL +H PL Sbjct: 719 AMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATPLQVHAPL 778 Query: 777 MPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQV 836 PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL++LFVEDGKM+RQ+ Sbjct: 779 SPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQM 838 Query: 837 FLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNG 896 FLATWKDIPNENE QFQI++C LNA+ SSKLQ++N++T+AKRNVEGQDMLYQSLKLTNG Sbjct: 839 FLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNG 898 Query: 897 IWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 937 IW+LAELRIQPGNP+ T LSLKCRAPEVSQ++YQ Y++ILKN Sbjct: 899 IWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 942 >gi|22027651 adaptor-related protein complex 1 beta 1 subunit isoform a [Homo sapiens] Length = 949 Score = 1565 bits (4053), Expect = 0.0 Identities = 795/951 (83%), Positives = 870/951 (91%), Gaps = 16/951 (1%) Query: 1 MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQT 60 MTDSKYFTT KKGEIFELKAELN++KKEK+KEAVKKVIA+MTVGKDVS+LFPDVVNCMQT Sbjct: 1 MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQT 60 Query: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 DNLELKKLVYLYLMNYAKSQPDMAIMAVN+FVKDCEDPNPLIRALAVRTMGCIRVDKITE Sbjct: 61 DNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITE 120 Query: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANA 180 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQ+VEDQGFLD+L+DLI+DSNPMVVANA Sbjct: 121 YLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANA 180 Query: 181 VAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSI 240 VAALSEI+ESHP+SNLLDLNPQ+INKLLTALNECTEWGQIFILDCL+NY PKDDREAQSI Sbjct: 181 VAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSI 240 Query: 241 CERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQY 300 CERVTPRLSHANSAVVLSAVKVLMKF+E+L KD DYY LLKKLAPPLVTLLS EPE+QY Sbjct: 241 CERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQY 300 Query: 301 VALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 VALRNINLIVQKRPEILK E+KVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE Sbjct: 301 VALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKE 360 Query: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRK 420 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVI+DIFRK Sbjct: 361 YATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRK 420 Query: 421 YPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 YPNKYES+IATLCENLDSLDEP+ARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV Sbjct: 421 YPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQV 480 Query: 481 QLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEV 540 QL LLTAIVKLFLKKP+ETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPV AKEV Sbjct: 481 QLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEV 540 Query: 541 VLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGST 600 VL+EKPLISEETDLIEPTLLDELIC+IG+LASVYHKPP+AFVEG G+ K LP S+ Sbjct: 541 VLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASS 600 Query: 601 DAGDSP-VGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQV--SSMQMGAVDLLG 657 ++ +SP T A EQP VIP+QGDLLGDLLNLDLGPPV+ P + SS+QMGAVDLLG Sbjct: 601 ESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLG 660 Query: 658 GGLDSLVGQSFIPSSVPAT-FAPSPTPAV-------VSSGLNDLFELSTGIGMAPGGYVA 709 GGLDSL+G P + T F PT AV + SGL+DLF+L++G+G G YVA Sbjct: 661 GGLDSLMGDE--PEGIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVA 718 Query: 710 PKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTP 769 PKAVWLPA+KAKGLEISGTFT + G I M++ TNKALQ MTDFAIQFN+NSFG+ P+TP Sbjct: 719 PKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPATP 778 Query: 770 LAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVED 829 L +H PL PNQ++++SLPL+T+G VMKMEPLNNLQVAVKNNIDVFYFS L PL++LFVED Sbjct: 779 LQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVED 838 Query: 830 GKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQ 889 GKM+RQ+FLATWKDIPNENE QFQI++C LNA+ SSKLQ++N++T+AKRNVEGQDMLYQ Sbjct: 839 GKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQ 898 Query: 890 SLKLTNGIWILAELRIQPGNPNYT---LSLKCRAPEVSQYIYQVYDSILKN 937 SLKLTNGIW+LAELRIQPGNP+ T LSLKCRAPEVSQ++YQ Y++ILKN Sbjct: 899 SLKLTNGIWVLAELRIQPGNPSCTDLELSLKCRAPEVSQHVYQAYETILKN 949 >gi|166197671 adaptor-related protein complex 4, beta 1 subunit [Homo sapiens] Length = 739 Score = 301 bits (772), Expect = 1e-81 Identities = 184/619 (29%), Positives = 325/619 (52%), Gaps = 18/619 (2%) Query: 17 ELKAELNNEKKE----KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLY 72 ELK L N + + + +++VI MT G D+S +F ++V T ++ KKLVYLY Sbjct: 12 ELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLY 71 Query: 73 LMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132 + YA +PD+A++A+N+ KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D Sbjct: 72 MCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRD 131 Query: 133 EDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192 + YVR+ A + AK+H+++ D ++ L L+ D +P+VV N + +L EI + Sbjct: 132 KASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEG 191 Query: 193 NSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN 252 + +N + LL +++ +WGQ +L+ L Y P+ + E I + L ++ Sbjct: 192 G---VVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSS 248 Query: 253 SAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQK 312 VV+ A K+ + ++ P ++L++ P L S E+ +VAL ++ I+ Sbjct: 249 PGVVMGATKLFLILAKMFPHVQT--DVLVRVKGPLLAACSSESRELCFVALCHVRQILHS 306 Query: 313 RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRK 372 P K FF Y++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF + Sbjct: 307 LPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQA 366 Query: 373 AVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATL 432 A+ AIG A ++CV L +L+ + ++ + RD+ P E++ L Sbjct: 367 AIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQAL 423 Query: 433 CENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDES-TQVQLTLLTAIVKL 491 +++ + + + A+IW++G + ERI NA +LE F+E E+ V++ LLTA+++L Sbjct: 424 PGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRL 483 Query: 492 FLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEK--PLIS 549 FL +P+E Q+++ ++L ++ + +RDRG Y+RLL K ++ S K P + Sbjct: 484 FLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLG 543 Query: 550 EETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGT 609 D E ++ +L VY K A + G R + S+ A P+ Sbjct: 544 LLEDPAERP-VNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL-- 600 Query: 610 TTATNLEQPQVIPSQGDLL 628 N E+ Q +P G L+ Sbjct: 601 IPEENKERVQELPDSGALM 619 Score = 30.8 bits (68), Expect = 6.2 Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%) Query: 824 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 883 ++ V + ++ F TW + ++ Q + DT+ LQ N+ TIA Sbjct: 618 LMLVPNRQLTADYFEKTWLSLKVAHQ-QVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGS 676 Query: 884 QDM-LYQSLKLTNGIWILAELRIQPGNPNYTLSLK 917 + Y S + G L EL ++PGN +S+K Sbjct: 677 RPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVK 711 >gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo sapiens] Length = 1082 Score = 280 bits (715), Expect = 6e-75 Identities = 188/621 (30%), Positives = 313/621 (50%), Gaps = 75/621 (12%) Query: 17 ELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNY 76 +LK L+ K + EA+K+++A + GK+ S LFP VV + N+E+KKLVY+YL+ Y Sbjct: 41 DLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRY 100 Query: 77 AKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPY 136 A+ Q D+A++++++F + +DPN LIRA A+R + IRV I + +++ D PY Sbjct: 101 AEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPY 160 Query: 137 VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNL 196 VRKTAA + KL+ +++ +DQ ++ + L+AD +V + V A E+ Sbjct: 161 VRKTAAHAIPKLYSLDSDQ-KDQ-LIEVIEKLLADKTTLVAGSVVMAFEEVCPER----- 213 Query: 197 LDLNPQNINKLLTALNECTEWGQIFILDCLSNY-------------------------NP 231 +DL +N KL L + EWGQ+ I+ L+ Y + Sbjct: 214 IDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSE 273 Query: 232 KDDREAQSICE----------------------RVTPRLSHANSAVVLSAVKVLMKFLEL 269 +D+ + E R T L + SA V+ AV L + L Sbjct: 274 EDEAKGAGSEETAAAAAPSRKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQL--YFHL 331 Query: 270 LPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYN 329 PK + +A LV LL EVQYV L+N+ + KR + + +K F+++ Sbjct: 332 APKAE------VGVIAKALVRLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFYIRST 385 Query: 330 DPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389 DP +K+ KL+++ LA++ NI VL E + Y +D DFV ++AIGRCA + + + Sbjct: 386 DPTQIKILKLEVLTNLANETNIPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRD 445 Query: 390 RCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMI 449 C++ L+ L+ + VV E++VVI+ + + P ++ II L + D++ P ARA+++ Sbjct: 446 TCLNGLVQLLSNRDELVVAESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASIL 505 Query: 450 WIVGEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLS 508 W++GEY E + A ++L + F E V+L ++ KL+L +T+ L Q VLS Sbjct: 506 WLIGEYCEHVPRIAPDVLRKMAKSFTAEEDIVKLQVINLAAKLYLTNSKQTKLLTQYVLS 565 Query: 509 LATQDSDNPDLRDRGYIYWRLLSTDPV------TAKEVVLSEKPLISEETDLIEPTLLDE 562 LA D N D+RDR +L+ AK++ L+ KP ++E + D Sbjct: 566 LAKYD-QNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKP-----APVLESSFKDR 619 Query: 563 LICHIGSLASVYHKPPNAFVE 583 +GSL+ + + + E Sbjct: 620 DHFQLGSLSHLLNAKATGYQE 640 >gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo sapiens] Length = 1094 Score = 270 bits (690), Expect = 5e-72 Identities = 179/621 (28%), Positives = 314/621 (50%), Gaps = 69/621 (11%) Query: 11 KKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVY 70 KK E +LK L + K + +A+K+++ + GK+ S LFP VV + + N+E+KKLVY Sbjct: 42 KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVY 99 Query: 71 LYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCL 130 +YL+ YA+ Q D+A++++++F + +DPN LIRA A+R + IRV I + +++ Sbjct: 100 VYLVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAS 159 Query: 131 KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISES 190 D PYVRK AA + KL+ ++ + E ++ + L+ D + +V + V A E+ Sbjct: 160 ADLSPYVRKNAAHAIQKLYSLDPEQKEM--LIEVIEKLLKDKSTLVAGSVVMAFEEVCPD 217 Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNY--------------------- 229 +DL +N KL L + EWGQ+ I+ L+ Y Sbjct: 218 R-----IDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKN 272 Query: 230 --NPKDDREAQS---------------ICERVTPRLSHANSAVVLSAVKVLMKFLELLPK 272 DD++ ++ + P L N+AVV++ ++ + + PK Sbjct: 273 FYESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQL---YWHISPK 329 Query: 273 DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPI 332 ++ LV LL EVQY+ L+NI + +R + + +K F+V+ DP Sbjct: 330 SEAGI------ISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPT 383 Query: 333 YVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCV 392 +K KL+I+ LA++ANI+ +L E + Y D F ++ IGRCA + + + C+ Sbjct: 384 MIKTLKLEILTNLANEANISTLLREFQTYVKSQDKQFAAATIQTIGRCATNILEVTDTCL 443 Query: 393 STLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIV 452 + L+ L+ + VV E++VVI+ + + P ++ II + + LDS+ P ARA+++W++ Sbjct: 444 NGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLLDSITVPVARASILWLI 503 Query: 453 GEYAERIDN-ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLAT 511 GE ER+ A ++L + F E V+L +L KL+L +T+ L Q +L+L Sbjct: 504 GENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKLYLTNSKQTKLLTQYILNLGK 563 Query: 512 QDSDNPDLRDRGYIYWRLLSTDPVT------AKEVVLSEKPLISEETDLIEPTLLDELIC 565 D N D+RDR +L+ + + AK++ L++KP L+E D Sbjct: 564 YD-QNYDIRDRTRFIRQLIVPNVKSGALSKYAKKIFLAQKP-----APLLESPFKDRDHF 617 Query: 566 HIGSLASVYHKPPNAFVEGSH 586 +G+L+ + ++E S+ Sbjct: 618 QLGTLSHTLNIKATGYLELSN 638 >gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [Homo sapiens] Length = 939 Score = 95.9 bits (237), Expect = 2e-19 Identities = 127/596 (21%), Positives = 247/596 (41%), Gaps = 59/596 (9%) Query: 10 NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59 +K+ EI + EL N + + +K+ V K++ +G D+ + VN + Sbjct: 25 SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84 Query: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119 ++ K++ YL++ S ++ + N+ D NP LA+ + + ++ Sbjct: 85 SNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMA 144 Query: 120 EYLCEPLRKCLKDEDPY--VRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177 E + K L D V+++AA+C+ +L+ + +V + + L+ D + VV Sbjct: 145 EAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVV 204 Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLLTA----LNECT------EWGQIFILDC 225 A + ++ +++ +P + L +++++T+ L + T W + +L Sbjct: 205 TAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRL 264 Query: 226 LSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVK-------VLMKFLELLPKDSDYYN 278 L Y P D + E + L+ A V+ VL + + L+ N Sbjct: 265 LQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPN 324 Query: 279 MLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--VKYNDPIYV 334 +L++ L E ++Y+AL ++ + E +K I+ +K + V Sbjct: 325 LLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSV 384 Query: 335 KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394 + +D++ + ++N Q++AE+ Y D + V + A K V T Sbjct: 385 RQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDT 444 Query: 395 LLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLDSLDEPDAR 445 +L+LI+ +YV +E IV+ RD + Y K +E++ A C ENL + Sbjct: 445 ILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGG---- 500 Query: 446 AAMIWIVGEYAERI---DNADELLESFL--EGFHDESTQVQLTLLTAIVKLFLKKPSETQ 500 +I+GE+ I + L++ L FH S + LL+ +K F+ E + Sbjct: 501 ----YILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIK-FVNLFPEVK 555 Query: 501 ELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLI 555 +Q VL +Q + + +L+ R Y RL + VL E P E I Sbjct: 556 PTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSI 611 >gi|19913416 adaptor-related protein complex 2, alpha 1 subunit isoform 2 [Homo sapiens] Length = 955 Score = 94.0 bits (232), Expect = 6e-19 Identities = 201/994 (20%), Positives = 389/994 (39%), Gaps = 141/994 (14%) Query: 10 NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59 +K+ EI + EL N + + +K+ V K++ +G D+ + VN + Sbjct: 25 SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84 Query: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119 ++ K++ YL++ S ++ + N+ D NP LA+ + + ++ Sbjct: 85 SNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMG 144 Query: 120 EYLCEPLRKCL--KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177 E + + L D V+++AA+C+ +L+ + +V + + L+ D + VV Sbjct: 145 EAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204 Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLL----TALNECT------EWGQIFILDC 225 AV+ ++ + + +P+ + L +++++ T L + T W + +L Sbjct: 205 TAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRL 264 Query: 226 LSNYNPKDD---------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFLELL 270 L Y P +D +AQ + + S+A +A++ + +++ + Sbjct: 265 LQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY---- 320 Query: 271 PKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--V 326 DS+ N+L++ L E ++Y+AL ++ + E +K I + Sbjct: 321 --DSE-PNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINAL 377 Query: 327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQ 386 K + V+ D++ + ++N Q+++E+ Y D + V + A K Sbjct: 378 KTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAV 437 Query: 387 SAERCVSTLLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLD 437 V T+L+LI+ +YV +E IV RD + Y K +E++ A C EN+ Sbjct: 438 DYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMV 497 Query: 438 SLDEPDARAAMIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLTLLTAIVKLF 492 + +I+GE+ I ++ + S L FH S + LL+ +K F Sbjct: 498 KVGG--------YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-F 548 Query: 493 LKKPSETQELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEE 551 + ET+ +Q VL +Q + + +L+ R Y L S VL E P E Sbjct: 549 INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPER 608 Query: 552 TDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTT 611 I L + GS + P++ + G P +T Sbjct: 609 ESSILAKLKRKKGPGAGSALDDGRRDPSS-----------------NDINGGMEPTPSTV 651 Query: 612 ATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPS 671 +T PS DLL L PP P S+ GA +LL D P+ Sbjct: 652 ST--------PSPS---ADLLGLRAAPPPAAPPASA---GAGNLLVDVFDG-------PA 690 Query: 672 SVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTH 731 + P + P+P A +S G D+ +V L + + + F Sbjct: 691 AQP-SLGPTPEEAFLSPGPEDIGPPIPEADELLNKFVCKNNGVLFENQLLQIGVKSEFRQ 749 Query: 732 RQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP----STPLAIHTPLMPNQSIDVSLP 787 G +Y + + NK ++QF S V+ T LA+ T + Q +D Sbjct: 750 NLGRMY--LFYGNKT-------SVQFQNFSPTVVHPGDLQTQLAVQTKRVAAQ-VDGGAQ 799 Query: 788 LNTLGPVMKMEPLNNLQVAVKNNIDVFY------FSCLIPLNV-LFVEDGKMERQVFLAT 840 + V+ +E L + ++ Y + +P+ + F + +M Q F Sbjct: 800 VQ---QVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFFQPTEMAAQDFFQR 856 Query: 841 WKDIP-NENELQFQIKECH-LNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIW 898 WK + + E Q K H ++A+ +KL + + ++ + + T + Sbjct: 857 WKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPENFVGAGIIQTKALQ 916 Query: 899 ILAELRIQPG--NPNYTLSLKCRAPEVSQYIYQV 930 + LR++P Y L+L+ VS+++ ++ Sbjct: 917 VGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCEL 950 >gi|19913414 adaptor-related protein complex 2, alpha 1 subunit isoform 1 [Homo sapiens] Length = 977 Score = 90.9 bits (224), Expect = 5e-18 Identities = 201/1007 (19%), Positives = 387/1007 (38%), Gaps = 145/1007 (14%) Query: 10 NKKGEIFELKAELNNEKKE----------KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQ 59 +K+ EI + EL N + + +K+ V K++ +G D+ + VN + Sbjct: 25 SKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLS 84 Query: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119 ++ K++ YL++ S ++ + N+ D NP LA+ + + ++ Sbjct: 85 SNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMG 144 Query: 120 EYLCEPLRKCL--KDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVV 177 E + + L D V+++AA+C+ +L+ + +V + + L+ D + VV Sbjct: 145 EAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204 Query: 178 ANAVAALSEISESHPN--SNLLDLNPQNINKLL----TALNECT------EWGQIFILDC 225 AV+ ++ + + +P+ + L +++++ T L + T W + +L Sbjct: 205 TAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRL 264 Query: 226 LSNYNPKDD---------------REAQSICERVTPRLSHANSAVVLSAVKVLMKFLELL 270 L Y P +D +AQ + + S+A +A++ + +++ + Sbjct: 265 LQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY---- 320 Query: 271 PKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKR--PEILKQEIKVFF--V 326 DS+ N+L++ L E ++Y+AL ++ + E +K I + Sbjct: 321 --DSE-PNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIDTVINAL 377 Query: 327 KYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQ 386 K + V+ D++ + ++N Q+++E+ Y D + V + A K Sbjct: 378 KTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYLETADYAIREEIVLKVAILAEKYAV 437 Query: 387 SAERCVSTLLDLIQTKVNYVVQEA------IVVIRDIFRKYPNK--YESIIATLC-ENLD 437 V T+L+LI+ +YV +E IV RD + Y K +E++ A C EN+ Sbjct: 438 DYSWYVDTILNLIRIAGDYVSEEVWYRVLQIVTNRDDVQGYAAKTVFEALQAPACHENMV 497 Query: 438 SLDEPDARAAMIWIVGEYAERI----DNADELLESFLEG-FHDESTQVQLTLLTAIVKLF 492 + +I+GE+ I ++ + S L FH S + LL+ +K F Sbjct: 498 KVGG--------YILGEFGNLIAGDPRSSPPVQFSLLHSKFHLCSVATRALLLSTYIK-F 548 Query: 493 LKKPSETQELVQQVLSLATQ-DSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEE 551 + ET+ +Q VL +Q + + +L+ R Y L S VL E P E Sbjct: 549 INLFPETKATIQGVLRAGSQLRNADVELQQRAVEYLTLSSVASTDVLATVLEEMPPFPER 608 Query: 552 TDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTT 611 I L + GS + P++ + G P +T Sbjct: 609 ESSILAKLKRKKGPGAGSALDDGRRDPSS-----------------NDINGGMEPTPSTV 651 Query: 612 ATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPS 671 +T PS DLL L PP P S+ GA +LL D Q + Sbjct: 652 ST--------PSPS---ADLLGLRAAPPPAAPPASA---GAGNLLVDVFDGPAAQPSLGP 697 Query: 672 SVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTH 731 + F P S + L + AP P+ + P +A E+ F Sbjct: 698 TPEEAFLSELEPPAPESPMALLAD------PAPAADPGPEDIGPPIPEAD--ELLNKFVC 749 Query: 732 RQGHIYME-------------MNFTNKALQHMTDFAIQFNKNSFGVIP----STPLAIHT 774 + + E N L + ++QF S V+ T LA+ T Sbjct: 750 KNNGVLFENQLLQIGVKSEFRQNLGRMYLFYGNKTSVQFQNFSPTVVHPGDLQTQLAVQT 809 Query: 775 PLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFY------FSCLIPLNV-LFV 827 + Q +D + V+ +E L + ++ Y + +P+ + F Sbjct: 810 KRVAAQ-VDGGAQVQ---QVLNIECLRDFLTPPLLSVRFRYGGAPQALTLKLPVTINKFF 865 Query: 828 EDGKMERQVFLATWKDIP-NENELQFQIKECH-LNADTVSSKLQNNNVYTIAKRNVEGQD 885 + +M Q F WK + + E Q K H ++A+ +KL + + ++ Sbjct: 866 QPTEMAAQDFFQRWKQLSLPQQEAQKIFKANHPMDAEVTKAKLLGFGSALLDNVDPNPEN 925 Query: 886 MLYQSLKLTNGIWILAELRIQPG--NPNYTLSLKCRAPEVSQYIYQV 930 + + T + + LR++P Y L+L+ VS+++ ++ Sbjct: 926 FVGAGIIQTKALQVGCLLRLEPNAQAQMYRLTLRTSKEPVSRHLCEL 972 >gi|117553580 adaptor-related protein complex 3, delta 1 subunit isoform 2 [Homo sapiens] Length = 1153 Score = 88.2 bits (217), Expect = 3e-17 Identities = 97/478 (20%), Positives = 198/478 (41%), Gaps = 32/478 (6%) Query: 15 IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74 I E+K EL + + AV K+ +G D+S +++ M K++ YL Sbjct: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99 Query: 75 NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134 D+ ++ N KD P+ +A+ + C + L + + Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159 Query: 135 PYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNS 194 PY+RK A + + K+ + + L++ + D +P V + AV + E++ +P Sbjct: 160 PYIRKKAVLIMYKVFLKYPESLRPA--FPRLKEKLEDPDPGVQSAAVNVICELARRNP-K 216 Query: 195 NLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSA 254 N L L P + ++ N W I I+ P + R + + E +T L H+ SA Sbjct: 217 NYLSLAPLFFKLMTSSTN---NWVLIKIIKLFGALTPLEPRLGKKLIEPLT-NLIHSTSA 272 Query: 255 VVL------SAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINL 308 + L + + VL+ +P S + ++KL + + + ++Y+ L ++ Sbjct: 273 MSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLR---ILIEDSDQNLKYLGLLAMSK 329 Query: 309 IVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRLASQANIAQVLAEL-----KEYA 362 I++ P+ ++ + +D ++L LD++ + S+ N+ +++ +L K Sbjct: 330 ILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEG 389 Query: 363 TEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQ---TKVNYVV--QEAIVVIR-D 416 T + + K + + + + E +S L++L + T+ +++ Q V IR Sbjct: 390 TTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 449 Query: 417 IFRKYPNKYESIIATLCENLDSLDEP----DARAAMIWIVGEYAERIDNADELLESFL 470 RK+ S + L S + + A WI GE++E + LE+ L Sbjct: 450 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAML 507 >gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapiens] Length = 953 Score = 79.0 bits (193), Expect = 2e-14 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%) Query: 18 LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76 LK +L + + EA+KKVI + G+ + L ++ + + +KKL+ ++ Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85 Query: 77 AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131 K+ PD I+ +++ KD + PN IR +R + ++ ++ E L +R CL+ Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145 Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190 YVR+ A + + ++ ++ D L + D L+ + + NA L + Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203 Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250 + ++ L T +++ +G I Q + + ++ H Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236 Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303 AN + ++ + L+ Y + A LVTL S ++ Y+ L Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290 Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348 N+ LIV R LK+ + + V + V+ + L + + L S Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350 Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400 N+ +++ LK+ + D D R+ VR + C+++ A + L++ + Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410 Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460 + + +R+ +++ N I+ + E ++ +WI+GEY Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466 Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512 + E ++S + ++ + + KP E Q+LV ++ + ATQ Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526 Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555 + D P LR D + L+T T ++ L L+ E+ + + Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583 Query: 556 EPTLLDELICHIGSLASVYHKP 577 E LL I H+G +S+ KP Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604 >gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapiens] Length = 953 Score = 79.0 bits (193), Expect = 2e-14 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%) Query: 18 LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76 LK +L + + EA+KKVI + G+ + L ++ + + +KKL+ ++ Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85 Query: 77 AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131 K+ PD I+ +++ KD + PN IR +R + ++ ++ E L +R CL+ Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145 Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190 YVR+ A + + ++ ++ D L + D L+ + + NA L + Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203 Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250 + ++ L T +++ +G I Q + + ++ H Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236 Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303 AN + ++ + L+ Y + A LVTL S ++ Y+ L Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290 Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348 N+ LIV R LK+ + + V + V+ + L + + L S Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350 Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400 N+ +++ LK+ + D D R+ VR + C+++ A + L++ + Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410 Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460 + + +R+ +++ N I+ + E ++ +WI+GEY Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466 Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512 + E ++S + ++ + + KP E Q+LV ++ + ATQ Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526 Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555 + D P LR D + L+T T ++ L L+ E+ + + Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583 Query: 556 EPTLLDELICHIGSLASVYHKP 577 E LL I H+G +S+ KP Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604 >gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] Length = 953 Score = 79.0 bits (193), Expect = 2e-14 Identities = 122/622 (19%), Positives = 244/622 (39%), Gaps = 105/622 (16%) Query: 18 LKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLYLMNY 76 LK +L + + EA+KKVI + G+ + L ++ + + +KKL+ ++ Sbjct: 26 LKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIV 85 Query: 77 AKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131 K+ PD I+ +++ KD + PN IR +R + ++ ++ E L +R CL+ Sbjct: 86 PKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLE 145 Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRD-LIADSNPMVVANAVAALSEISES 190 YVR+ A + + ++ ++ D L + D L+ + + NA L + Sbjct: 146 HRHSYVRRNAVLAIYTIYRNFEHLIPDAPEL--IHDFLVNEKDASCKRNAFMMLIHADQD 203 Query: 191 HPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSH 250 + ++ L T +++ +G I Q + + ++ H Sbjct: 204 -----------RALDYLSTCIDQVQTFGDIL----------------QLVIVELIYKVCH 236 Query: 251 ANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQ-----YVAL-- 303 AN + ++ + L+ Y + A LVTL S ++ Y+ L Sbjct: 237 ANPSERARFIRCIYNLLQSSSPAVKY------EAAGTLVTLSSAPTAIKAAAQCYIDLII 290 Query: 304 ----RNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQ 348 N+ LIV R LK+ + + V + V+ + L + + L S Sbjct: 291 KESDNNVKLIVLDRLIELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSS 350 Query: 349 ANIAQVLAELKEYATEV-------DVDFVRK-AVRAIGRCAIKVEQSAERCVSTLLDLIQ 400 N+ +++ LK+ + D D R+ VR + C+++ A + L++ + Sbjct: 351 RNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLS 410 Query: 401 TKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460 + + +R+ +++ N I+ + E ++ +WI+GEY Sbjct: 411 DNNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWILGEYC---- 466 Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSE------TQELVQQVLSLATQ-- 512 + E ++S + ++ + + KP E Q+LV ++ + ATQ Sbjct: 467 STKEDIQSVMTEIRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSA 526 Query: 513 ---------DSDNPDLR----DRGYIYWRLLSTDPVTAKEVVLSEKPLISEE----TDLI 555 + D P LR D + L+T T ++ L L+ E+ + + Sbjct: 527 LSSSRPTKKEEDRPPLRGFLLDGDFFVAASLAT---TLTKIALRYVALVQEKKKQNSFVA 583 Query: 556 EPTLLDELICHIGSLASVYHKP 577 E LL I H+G +S+ KP Sbjct: 584 EAMLLMATILHLGK-SSLPKKP 604 >gi|71772942 adaptor-related protein complex 1, gamma 1 subunit isoform b [Homo sapiens] Length = 822 Score = 76.3 bits (186), Expect = 1e-13 Identities = 158/783 (20%), Positives = 296/783 (37%), Gaps = 97/783 (12%) Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125 K++ YL M + D+ ++ N D ++ LA+ T+GC+ ++ L Sbjct: 82 KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141 Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185 + K LK + Y+RK AA+C +H I + FL + ++L+ + N V+ +V L+ Sbjct: 142 VEKLLKTSNSYLRKKAALCA--VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLT 199 Query: 186 EISESHPN--SNLLDLNPQNINKLLTALNE-----------CTEWGQIFILDCLSNYNPK 232 E+ E P+ ++ L PQ + L + + Q+ IL L Sbjct: 200 EMCERSPDMLAHFRKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRILGRN 259 Query: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286 DD ++++ + + T + +A++ V +M + +S + + L Sbjct: 260 DDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMD----IKSESGLRVLAINILGR 315 Query: 287 PLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIMIRL 345 LL+ + ++YVAL ++ VQ +++ D + +K +++ L Sbjct: 316 ---FLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFAL 372 Query: 346 ASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405 + NI ++ EL + + +F I A K S + T++ ++ T +Y Sbjct: 373 VNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSY 432 Query: 406 VVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERIDNAD 463 V +A+ + + + + L + + D +P + A W +GEY + + Sbjct: 433 VRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLL---- 487 Query: 464 ELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRG 523 + G +E +Q+T E ++++ VL S+ RG Sbjct: 488 ------VSGQCEEEEPIQVT------------EDEVLDILESVLI-----SNMSTSVTRG 524 Query: 524 YIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVE 583 Y ++ V K ++S I+ L + +L Y +A +E Sbjct: 525 YALTAIMKLS-TRFTCTVNRIKKVVSIYGSSIDVELQQRAV-EYNALFKKYDHMRSALLE 582 Query: 584 GSHGIHRKHLPIHHGSTDAGDSPV----GTTTATNLE--QPQVIPSQGDLLGDLLNLDLG 637 +P+ T G + + G T LE P P DLL+L LG Sbjct: 583 --------RMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDL-LG 633 Query: 638 PPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELS 697 P + + GG L L+G + + A AP+ P + L Sbjct: 634 GNDITPVIPTAPTSKPSSAGGELLDLLGDINLTGAPAAAPAPASVPQISQPPF-----LL 688 Query: 698 TGIGMAP-GGYVAPKAVWLPAVKAKGLEISGTFTHRQGH---IYMEMNFTNKALQHMTDF 753 G+ P +A + A GL+I TF + + + +N MTDF Sbjct: 689 DGLSSQPLFNDIAAGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDMTDF 748 Query: 754 AIQFNKNSFGVIPST-PLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNID 812 Q +P T L + L P+ SI + T+ V+K+ LN + ++ I Sbjct: 749 VFQ------AAVPKTFQLQL---LSPSSSIVPAFNTGTITQVIKV--LNPQKQQLRMRIK 797 Query: 813 VFY 815 + Y Sbjct: 798 LTY 800 >gi|71773010 adaptor-related protein complex 1, gamma 1 subunit isoform a [Homo sapiens] Length = 825 Score = 74.3 bits (181), Expect = 5e-13 Identities = 158/786 (20%), Positives = 295/786 (37%), Gaps = 100/786 (12%) Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125 K++ YL M + D+ ++ N D ++ LA+ T+GC+ ++ L Sbjct: 82 KRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTLGCMGSSEMCRDLAGE 141 Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185 + K LK + Y+RK AA+C +H I + FL + ++L+ + N V+ +V L+ Sbjct: 142 VEKLLKTSNSYLRKKAALCA--VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLT 199 Query: 186 EISESHPNSNL-LDLNPQNINKLLTALNECTEWG---------------QIFILDCLSNY 229 E+ E P+ N + + +L+ L G Q+ IL L Sbjct: 200 EMCERSPDMLAHFRKNEKLVPQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILRLLRIL 259 Query: 230 NPKDDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKK 283 DD ++++ + + T + +A++ V +M + +S + + Sbjct: 260 GRNDDDSSEAMNDILAQVATNTETSKNVGNAILYETVLTIMD----IKSESGLRVLAINI 315 Query: 284 LAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYND-PIYVKLEKLDIM 342 L LL+ + ++YVAL ++ VQ +++ D + +K +++ Sbjct: 316 LGR---FLLNNDKNIRYVALTSLLKTVQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELS 372 Query: 343 IRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTK 402 L + NI ++ EL + + +F I A K S + T++ ++ T Sbjct: 373 FALVNGNNIRGMMKELLYFLDSCEPEFKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTA 432 Query: 403 VNYVVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERID 460 +YV +A+ + + + + L + + D +P + A W +GEY + + Sbjct: 433 GSYVRDDAVPNLIQLITNSVEMHAYTVQRLYKAILGDYSQQPLVQVA-AWCIGEYGDLL- 490 Query: 461 NADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLR 520 + G +E +Q+T E ++++ VL S+ Sbjct: 491 ---------VSGQCEEEEPIQVT------------EDEVLDILESVLI-----SNMSTSV 524 Query: 521 DRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNA 580 RGY ++ V K ++S I+ L + +L Y +A Sbjct: 525 TRGYALTAIMKLS-TRFTCTVNRIKKVVSIYGSSIDVELQQRAV-EYNALFKKYDHMRSA 582 Query: 581 FVEGSHGIHRKHLPIHHGSTDAGDSPV----GTTTATNLE--QPQVIPSQGDLLGDLLNL 634 +E +P+ T G + + G T LE P P DLL+L Sbjct: 583 LLE--------RMPVMEKVTTNGPTEIVQTNGETEPAPLETKPPPSGPQPTSQANDLLDL 634 Query: 635 DLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLF 694 LG P + + GG L L+G + + A AP+ P + Sbjct: 635 -LGGNDITPVIPTAPTSKPSSAGGELLDLLGDINLTGAPAAAPAPASVPQISQPPF---- 689 Query: 695 ELSTGIGMAP-GGYVAPKAVWLPAVKAKGLEISGTFTHRQGH---IYMEMNFTNKALQHM 750 L G+ P +A + A GL+I TF + + + +N M Sbjct: 690 -LLDGLSSQPLFNDIAAGIPSITAYSKNGLKIEFTFERSNTNPSVTVITIQASNSTELDM 748 Query: 751 TDFAIQFNKNSFGVIPST-PLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKN 809 TDF Q +P T L + L P+ SI + T+ V+K+ LN + ++ Sbjct: 749 TDFVFQ------AAVPKTFQLQL---LSPSSSIVPAFNTGTITQVIKV--LNPQKQQLRM 797 Query: 810 NIDVFY 815 I + Y Sbjct: 798 RIKLTY 803 >gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sapiens] Length = 871 Score = 65.5 bits (158), Expect = 2e-10 Identities = 86/493 (17%), Positives = 206/493 (41%), Gaps = 30/493 (6%) Query: 46 DVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRAL 105 + + F + Q+++ L+++ YL + A D+ I+ +S KD + R Sbjct: 65 EATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV-IIVTSSLTKDMTGKEDVYRGP 123 Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSL 165 A+R + I + + + +++ + D+ V +A V + I+ +V+ +++ Sbjct: 124 AIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALVSSLHMMKISYDVVKR--WINEA 181 Query: 166 RDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDC 225 ++ + N MV +A+ L + ++ + LN + L + C + I Sbjct: 182 QEAASSDNIMVQYHALGVLYHLRKNDRLAVSKMLNKFTKSGLKSQFAYC-----MLIRIA 236 Query: 226 LSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLA 285 +D + + + L + + V+ A ++ LP N ++LA Sbjct: 237 SRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAASAIIH----LP------NCTARELA 286 Query: 286 PPLVTLL----SGEPEVQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYVKLEK 338 P + L S +P ++Y A+R +N + K P + +++ N I Sbjct: 287 PAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLDLENLITDSNRSIATL--A 344 Query: 339 LDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDL 398 + +++ S++++ +++ ++ + +E+ +F V+AI K + ++ L ++ Sbjct: 345 ITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQKYPRKHSVMMTFLSNM 404 Query: 399 IQTKVNYVVQEAIV-VIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAE 457 ++ + + AIV I I + P E+ +A LCE ++ + ++ ++G+ Sbjct: 405 LRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEHTVLATKILHLLGKEGP 464 Query: 458 RIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNP 517 R + + E+ V+ ++A+ K + S ++ +L D+D+ Sbjct: 465 RTPVPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNESLLPSIL-VLLQRCMMDTDD- 522 Query: 518 DLRDRGYIYWRLL 530 ++RDR Y +L Sbjct: 523 EVRDRATFYLNVL 535 >gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapiens] Length = 874 Score = 62.4 bits (150), Expect = 2e-09 Identities = 90/500 (18%), Positives = 212/500 (42%), Gaps = 44/500 (8%) Query: 46 DVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRAL 105 + + F + Q+++ L+++ YL + + D+ I+ +S KD R Sbjct: 65 EATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV-IIVTSSLTKDMTGKEDNYRGP 123 Query: 106 AVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSL 165 AVR + I + + + +++ + D+ P V +A V+ LH + + +++ Sbjct: 124 AVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSA--LVSSLHLLKCSFDVVKRWVNEA 181 Query: 166 RDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE---CTEWGQIFI 222 ++ + N MV +A+ L + + N L +NK+++ + + + + Sbjct: 182 QEAASSDNIMVQYHALGLLYHVRK---NDRLA------VNKMISKVTRHGLKSPFAYCMM 232 Query: 223 LDCLSNYNPKDDREAQS-ICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLL 281 + S ++D S + + + L + + VV A ++ LP S Sbjct: 233 IRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVN----LPGCS------A 282 Query: 282 KKLAPPLVTL----LSGEPEVQYVALRNINLIVQKRPEIL---KQEIKVFFVKYNDPIYV 334 K+LAP + L S + ++Y A+R +N + K P + +++ N I Sbjct: 283 KELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIAT 342 Query: 335 KLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVST 394 + +++ S+++I +++ ++ + +E+ +F V+AI K + ++ Sbjct: 343 L--AITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNF 400 Query: 395 LLDLIQTKVNYVVQEAIV-VIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVG 453 L +++ + + + AIV I I + E+ ++ LCE ++ + ++ ++G Sbjct: 401 LFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLG 460 Query: 454 EYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSL---A 510 + + N + + E +V+ ++A+ K ++ +E++ +L L Sbjct: 461 QEGPKTTNPSKYIRFIYNRVVLEHEEVRAGAVSALAKF----GAQNEEMLPSILVLLKRC 516 Query: 511 TQDSDNPDLRDRGYIYWRLL 530 D DN ++RDR Y +L Sbjct: 517 VMDDDN-EVRDRATFYLNVL 535 >gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit [Homo sapiens] Length = 1137 Score = 60.5 bits (145), Expect = 7e-09 Identities = 99/467 (21%), Positives = 194/467 (41%), Gaps = 45/467 (9%) Query: 14 EIFELKAELN--NEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYL 71 E+ LKA ++ + KE + ++I +G D S + + Q NL K++ YL Sbjct: 59 ELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYL 118 Query: 72 YLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLK 131 + + ++ ++ VN+ VKD + N + +A+ + I ++ + + L+ Sbjct: 119 AVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQ 178 Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAV-AALSEISES 190 VR+ A + + K H I V Q R + D + V+A ++ L I E+ Sbjct: 179 HSKEIVRRKAVLALYKFHLIAPNQV--QHIHIKFRKALCDRDVGVMAASLHIYLRMIKEN 236 Query: 191 HPNSNLLDLNPQNI--------NKLLTALNECT---EWGQIFILDCLSNYNPKDDREAQS 239 +S DL + KL N + W QI +L L D R ++ Sbjct: 237 --SSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSEL 294 Query: 240 ICERVTPRLSHA---NSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPL-VTLLSGE 295 + + + L A ++ + + + PK LL+K A + +LS + Sbjct: 295 MYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSE-----LLEKAAKCIGKFVLSPK 349 Query: 296 PEVQYVALRNINLIVQKRPEILKQEIKVFF--VKYNDPIYVKLEKLDIMIRLASQANIAQ 353 ++Y+ L+ + ++Q+ P + Q + + DPI +K E L+++ R+ + NI Sbjct: 350 INLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPI-IKRETLELLYRITNAQNITV 408 Query: 354 VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVV 413 ++ ++ EY + ++V V +G K+ + AE+ IQT + V Sbjct: 409 IVQKMLEYLHQSKEEYV--IVNLVG----KIAELAEKYAPDNAWFIQT-----MNAVFSV 457 Query: 414 IRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERID 460 D+ +P+ + + L E D DE + + ++ V Y +D Sbjct: 458 GGDVM--HPDIPNNFLRLLAEGFD--DETEDQQLRLYAVQSYLTLLD 500 >gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo sapiens] Length = 785 Score = 54.3 bits (129), Expect = 5e-07 Identities = 93/493 (18%), Positives = 191/493 (38%), Gaps = 41/493 (8%) Query: 66 KKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEP 125 K++ YL M + D ++ NS D ++ LA+ T+ + ++ L Sbjct: 83 KRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPE 142 Query: 126 LRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALS 185 + K L PYVRK A + +H I FL L+ + + ++ + ++ Sbjct: 143 VEKLLLQPSPYVRKKA--ILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLIT 200 Query: 186 EISESHPNS--NLLDLNPQ--NINKLLTALNECTEWG---------QIFILDCLSNYNPK 232 E+ E P + + + PQ +I + L + TE Q+ IL L Sbjct: 201 ELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRN 260 Query: 233 DDREAQSICERV------TPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAP 286 + ++++ + + T +A +AV+ V +M N+L + Sbjct: 261 HEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGR---- 316 Query: 287 PLVTLLSGEPEVQYVALRNINLIVQK-RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRL 345 LL+ + ++YVAL ++ +VQ + + V + L++ + L Sbjct: 317 ---FLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALELSLAL 373 Query: 346 ASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNY 405 + +N+ ++ EL+ + D I A + + + T+L ++ T + Sbjct: 374 VNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKRWHIDTILHVLTTAGTH 433 Query: 406 VVQEAIVVIRDIFRKYPNKYESIIATLCENL--DSLDEPDARAAMIWIVGEYAERI--DN 461 V +A+ + + + + L L D +P + A W +GEY + + N Sbjct: 434 VRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPLVQVA-AWCIGEYGDLLLAGN 492 Query: 462 ADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQ-DSDNPDLR 520 +E +E + +V L LL +++ + P+ + ++ L+T+ DN +R Sbjct: 493 CEE-----IEPLQVDEEEV-LALLEKVLQSHMSLPATRGYALTALMKLSTRLCGDNNRIR 546 Query: 521 DRGYIYWRLLSTD 533 IY L + Sbjct: 547 QVVSIYGSCLDVE 559 >gi|117553584 adaptor-related protein complex 3, delta 1 subunit isoform 1 [Homo sapiens] Length = 1112 Score = 50.4 bits (119), Expect = 8e-06 Identities = 43/207 (20%), Positives = 76/207 (36%), Gaps = 27/207 (13%) Query: 15 IFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLM 74 I E+K EL + + AV K+ +G D+S +++ M K++ YL Sbjct: 40 IDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAAS 99 Query: 75 NYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDED 134 D+ ++ N KD P+ +A+ + C + L + + Sbjct: 100 QSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTK 159 Query: 135 PYVRKTA---------------------------AVCVAKLHDINAQMVEDQGFLDSLRD 167 PY+RK A AV ++ + Q + LR Sbjct: 160 PYIRKKAKLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRI 219 Query: 168 LIADSNPMVVANAVAALSEISESHPNS 194 LI DS+ + + A+S+I ++HP S Sbjct: 220 LIEDSDQNLKYLGLLAMSKILKTHPKS 246 Score = 37.0 bits (84), Expect = 0.086 Identities = 54/271 (19%), Positives = 120/271 (44%), Gaps = 27/271 (9%) Query: 222 ILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVL------SAVKVLMKFLELLPKDSD 275 I+ +S+ P ++A+ I E +T L H+ SA+ L + + VL+ +P S Sbjct: 151 IMTLMSHTKPYIRKKAKLI-EPLT-NLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSA 208 Query: 276 YYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIY-V 334 + ++KL + + + ++Y+ L ++ I++ P+ ++ + +D + Sbjct: 209 SIQLCVQKLR---ILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESI 265 Query: 335 KLEKLDIMIRLASQANIAQVLAEL-----KEYATEVDVDFVRKAVRAIGRCAIKVEQSAE 389 +L LD++ + S+ N+ +++ +L K T + + K + + + + E Sbjct: 266 RLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFE 325 Query: 390 RCVSTLLDLIQ---TKVNYVV--QEAIVVIR-DIFRKYPNKYESIIATLCENLDSLDEPD 443 +S L++L + T+ +++ Q V IR RK+ S + L S + + Sbjct: 326 WYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRN 385 Query: 444 ARAAMI----WIVGEYAERIDNADELLESFL 470 ++ WI GE++E + LE+ L Sbjct: 386 GICEVLYAAAWICGEFSEHLQEPHHTLEAML 416 >gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo sapiens] Length = 907 Score = 39.3 bits (90), Expect = 0.017 Identities = 50/196 (25%), Positives = 72/196 (36%), Gaps = 36/196 (18%) Query: 574 YHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQG--DLLGDL 631 + PP +G+ + L S DA +P TTA+ P + S G DL GD Sbjct: 594 FSSPP----QGASPVPESSLTADLLSVDAFAAPSPATTAS----PAKVDSSGVIDLFGDA 645 Query: 632 LNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIP-----------------SSVP 674 P Q +S + DLL G S + S P + P Sbjct: 646 FGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPAQNNLLQPNFEAAFGTTP 705 Query: 675 ATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLP-----AVKAKGLEISGTF 729 +T + S V GL DL + MAP G AP ++ P A KA G ++ + Sbjct: 706 STSSSSSFDPSVFDGLGDLLMPT----MAPAGQPAPVSMVPPSPAMAASKALGSDLDSSL 761 Query: 730 THRQGHIYMEMNFTNK 745 G++ + T K Sbjct: 762 ASLVGNLGISGTTTKK 777 >gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1 [Homo sapiens] Length = 1849 Score = 35.8 bits (81), Expect = 0.19 Identities = 50/216 (23%), Positives = 83/216 (38%), Gaps = 46/216 (21%) Query: 599 STDAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVD-LLG 657 STD GD VG +P + P +GD + D ++ P S+ + +G Sbjct: 1104 STDLGDEDVGLGPPAPRTRPSMFPEEGDFADE----DSAEQLSSPMPSATPREPENHFVG 1159 Query: 658 GGLDSLVGQSFIP-SSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLP 716 G S G++ P +S P +PAV S+ S+G PG YV P Sbjct: 1160 GAEASAPGEAGRPLNSTSKAQGPESSPAVPSA--------SSGTA-GPGNYVHP------ 1204 Query: 717 AVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIP----STPLAI 772 ++G + + ++ ++A++ + + G P + PL I Sbjct: 1205 --------LTGRLLDPSSPLALALSARDRAMK-------ESQQGPKGEAPKADLNKPLYI 1249 Query: 773 HTPLMPNQSIDVSLPL----NTLGPVMKMEPLNNLQ 804 T + P S+D P NT GP+ + E N + Sbjct: 1250 DTKMRP--SLDAGFPTVTRQNTRGPLRRQETENKYE 1283 >gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] Length = 509 Score = 35.8 bits (81), Expect = 0.19 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%) Query: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101 P +V C+Q + LK++ L + AK P++A V++ D + + + Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229 Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156 + AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +Q+V Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289 Query: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213 + G + ++ D I + L ++ N + + + + +L L+E Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346 >gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] Length = 458 Score = 35.8 bits (81), Expect = 0.19 Identities = 38/177 (21%), Positives = 78/177 (44%), Gaps = 15/177 (8%) Query: 52 PDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFV----------KDCEDPNPL 101 P +V C+Q + LK++ L + AK P++A V++ D + + + Sbjct: 170 PLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQI 229 Query: 102 IRALAVRTMGCIRV-DKITEYLCEPL-RKCLKDEDPYVRKTAAVC---VAKLHDINAQMV 156 + AL+ + + + + + E P+ CLKD+D YV+K A+ +AK +Q+V Sbjct: 230 LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLV 289 Query: 157 EDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNE 213 + G + ++ D I + L ++ N + + + + +L L+E Sbjct: 290 VNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSE 346 >gi|156104874 envoplakin [Homo sapiens] Length = 2033 Score = 35.4 bits (80), Expect = 0.25 Identities = 84/410 (20%), Positives = 157/410 (38%), Gaps = 57/410 (13%) Query: 132 DEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSE----I 187 +ED RK A VAKL Q ++ L I+ P V+ V + + + Sbjct: 1100 EEDAARRKQAEEAVAKL----------QARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149 Query: 188 SESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPR 247 ES S L L + K T E + D S Y+ + + + + Sbjct: 1150 QES---SRLRSLLEEERTKNATLARELS--------DLHSKYSVVEKQRPKVQLQERVHE 1198 Query: 248 LSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNIN 307 + + ++ K E+ K S + +KL P L L + +P V+Y + Sbjct: 1199 IFQVDPETEQEITRLKAKLQEMAGKRSGVEKEV-EKLLPDLEVLRAQKPTVEYKEVTQEV 1257 Query: 308 LIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQAN--------------IAQ 353 + ++ PE+L+ EI + N+ + + +IRL + + + Sbjct: 1258 VRHERSPEVLR-EIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKE 1316 Query: 354 VLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVS--TLLDLIQTKVNYVVQEAI 411 V+ K+ E + + +R+ VR + E + S LL+ + + VVQE + Sbjct: 1317 VVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVV 1376 Query: 412 VVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLE 471 V +D K + L +LD +E R + V + ++ + LL + Sbjct: 1377 VTQKD------PKLREEHSRLSGSLD--EEVGRRRQLELEVQQLRAGVEEQEGLLSFQED 1428 Query: 472 GFHDESTQVQLTLLTAIVKLFLKKPSETQE--LVQQVLSLATQDSDNPDL 519 + + +L LT ++ K+P QE ++++V+ L +PDL Sbjct: 1429 RSKKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKL----EKDPDL 1474 >gi|157694494 MYB binding protein 1a isoform 1 [Homo sapiens] Length = 1332 Score = 35.0 bits (79), Expect = 0.33 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 18/117 (15%) Query: 261 KVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320 + LMK ++LL + Y N L ++ LV +LS EV L+ I PE+LK + Sbjct: 154 EALMKSVKLLQALAQYQNHLQEQPRKALVDILS---EVSKATLQEI------LPEVLKAD 204 Query: 321 IKV---------FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVD 368 + + F+ + KL+KL + L S N+ +++ LK A+ V D Sbjct: 205 LNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKD 261 >gi|157694492 MYB binding protein 1a isoform 2 [Homo sapiens] Length = 1328 Score = 35.0 bits (79), Expect = 0.33 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 18/117 (15%) Query: 261 KVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQE 320 + LMK ++LL + Y N L ++ LV +LS EV L+ I PE+LK + Sbjct: 154 EALMKSVKLLQALAQYQNHLQEQPRKALVDILS---EVSKATLQEI------LPEVLKAD 204 Query: 321 IKV---------FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVD 368 + + F+ + KL+KL + L S N+ +++ LK A+ V D Sbjct: 205 LNIILSSPEQLELFLLAQQKVPSKLKKLVGSVNLFSDENVPRLVNVLKMAASSVKKD 261 >gi|45356151 non-SMC condensin II complex, subunit D3 [Homo sapiens] Length = 1498 Score = 34.7 bits (78), Expect = 0.43 Identities = 27/102 (26%), Positives = 49/102 (48%), Gaps = 8/102 (7%) Query: 82 DMAIMAVNSFVKD---CEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVR 138 D+A ++ + V++ CED + V CIR + + + CLKD DP++R Sbjct: 936 DLAKKSIPALVRELEVCEDVAVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIR 995 Query: 139 KTAAVCVAKLHDINAQMVEDQG--FLDSLRDLIADSNPMVVA 178 K + + L + + V+ +G F + LI DS+P + + Sbjct: 996 KQTLILLTNL--LQEEFVKWKGSLFFRFVSTLI-DSHPDIAS 1034 >gi|44680122 tripartite motif-containing 7 isoform 1 [Homo sapiens] Length = 511 Score = 34.3 bits (77), Expect = 0.56 Identities = 41/188 (21%), Positives = 74/188 (39%), Gaps = 36/188 (19%) Query: 210 ALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN---SAVVLSAVKVLMKF 266 A C + G+ F L C D R +C+R HA V A ++L Sbjct: 126 AAARCGQHGEPFKLYCQD-----DGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR 180 Query: 267 LELLPK---DSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKV 323 L +L K D + + KK + L+ ++ E Q++ Q ++ Sbjct: 181 LRVLKKELEDCEVFRSTEKKESKELLKQMAAE---------------QEKVGAEFQALRA 225 Query: 324 FFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAEL----------KEYATEVDVDFVRKA 373 F V+ + +LE+L + N+AQ+ E+ +E A + D+DF+++ Sbjct: 226 FLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEF 285 Query: 374 VRAIGRCA 381 + RC+ Sbjct: 286 KSTLSRCS 293 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 33,841,848 Number of Sequences: 37866 Number of extensions: 1533241 Number of successful extensions: 4491 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 20 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 4396 Number of HSP's gapped (non-prelim): 73 length of query: 937 length of database: 18,247,518 effective HSP length: 112 effective length of query: 825 effective length of database: 14,006,526 effective search space: 11555383950 effective search space used: 11555383950 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.