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Search of human proteins with 45505137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45505137 podocan [Homo sapiens]
(661 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45505137 podocan [Homo sapiens] 1314 0.0
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 456 e-128
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 456 e-128
gi|226342935 podocan-like 1 isoform 3 [Homo sapiens] 294 2e-79
gi|41349454 proline arginine-rich end leucine-rich repeat protei... 149 1e-35
gi|4506041 proline arginine-rich end leucine-rich repeat protein... 149 1e-35
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 146 7e-35
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 145 1e-34
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 145 1e-34
gi|5901992 keratocan [Homo sapiens] 145 2e-34
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 143 6e-34
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 139 6e-33
gi|225579152 insulin-like growth factor binding protein, acid la... 139 1e-32
gi|4826772 insulin-like growth factor binding protein, acid labi... 139 1e-32
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 134 2e-31
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 131 2e-30
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 131 2e-30
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 130 3e-30
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 128 1e-29
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 128 1e-29
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 126 6e-29
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 126 7e-29
gi|4502403 biglycan preproprotein [Homo sapiens] 124 3e-28
gi|41350214 asporin [Homo sapiens] 124 3e-28
gi|4507531 toll-like receptor 3 [Homo sapiens] 123 6e-28
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 120 3e-27
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 120 3e-27
gi|4505047 lumican precursor [Homo sapiens] 120 5e-27
gi|71040111 fibromodulin precursor [Homo sapiens] 117 3e-26
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 114 3e-25
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 1314 bits (3401), Expect = 0.0
Identities = 661/661 (100%), Positives = 661/661 (100%)
Query: 1 MEGARARGAQLRLGERVRPVGRRSAPGRSRFRQPWRPGASDSAPPAGTMAQSRVLLLLLL 60
MEGARARGAQLRLGERVRPVGRRSAPGRSRFRQPWRPGASDSAPPAGTMAQSRVLLLLLL
Sbjct: 1 MEGARARGAQLRLGERVRPVGRRSAPGRSRFRQPWRPGASDSAPPAGTMAQSRVLLLLLL 60
Query: 61 LPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDC 120
LPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDC
Sbjct: 61 LPPQLHLGPVLAVRAPGFGRSGGHSLSPEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDC 120
Query: 121 ACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL 180
ACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL
Sbjct: 121 ACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL 180
Query: 181 TSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPN 240
TSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPN
Sbjct: 181 TSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPN 240
Query: 241 LRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEK 300
LRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEK
Sbjct: 241 LRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEK 300
Query: 301 IPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV 360
IPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV
Sbjct: 301 IPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV 360
Query: 361 LLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALE 420
LLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALE
Sbjct: 361 LLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALE 420
Query: 421 RVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLL 480
RVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLL
Sbjct: 421 RVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLL 480
Query: 481 RSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
RSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL
Sbjct: 481 RSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
Query: 541 GPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIF 600
GPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIF
Sbjct: 541 GPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIF 600
Query: 601 LRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEET 660
LRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEET
Sbjct: 601 LRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEET 660
Query: 661 R 661
R
Sbjct: 661 R 661
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 456 bits (1174), Expect = e-128
Identities = 236/443 (53%), Positives = 305/443 (68%)
Query: 111 PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRL 170
P +CP C+C + VDC G+DLR FP ++ HLSLQNNQL+++ ELSRL L
Sbjct: 39 PLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGL 98
Query: 171 ETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKI 230
TLNL NN ++S GLP++AFE LT L +L +A+NKL++AP+FLP +L D AAN + +I
Sbjct: 99 RTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEI 158
Query: 231 YGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYK 290
+ LTFG+KP LRSVYLHNN+L++AGLP + F GS + L LS+N L ++P LPP+L +
Sbjct: 159 FPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLER 218
Query: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
LHL+NN + K+P GA S + LRELYLQ+N LTD GLD TF KL SLEYLDLS N L+
Sbjct: 219 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 278
Query: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
VPAGLPR+L +LHL +N IR V+A L R L YLLL NQL G+ A + L+ LH
Sbjct: 279 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 338
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
T+HLY N L+RVP LPRR+R L++ HN + +G D T L ELNL+YNR+ S +VH
Sbjct: 339 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 398
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
AFR+LR LRSLDL+GN+L LP GLP + L+++RN+L L L G+ QLREL L
Sbjct: 399 HRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 458
Query: 531 TSNRLRSRALGPRAWVDLAHLQL 553
NRLR +GP W +L LQ+
Sbjct: 459 AHNRLRVGDIGPGTWHELQALQV 481
Score = 206 bits (524), Expect = 6e-53
Identities = 130/354 (36%), Positives = 188/354 (53%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
LR P ++ A L L+NN+L+++P S LS LR L L NN ++ EGL +E F L+
Sbjct: 63 LRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLT 122
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
L++L ++ N LS P LPRSL + L N + + +L + LH+NQL
Sbjct: 123 QLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNA 182
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
G+ P AF+G + + T+ L NN L +P LP + L + +N I+ + R + L E
Sbjct: 183 GLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRE 242
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
L L +N++T + F KL L LDLS N+L T+P GLPR + +L + RN + +
Sbjct: 243 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 302
Query: 517 GALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLY 576
L G LR L L N+L S L A L L L + GN L +P LP L L
Sbjct: 303 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 362
Query: 577 LQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L +N ++A+ A +TP L + L +N+LA V AFRRL+ L+ LD+ GN
Sbjct: 363 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 416
Score = 147 bits (372), Expect = 2e-35
Identities = 93/293 (31%), Positives = 149/293 (50%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
++ +D +L P + R+ L L+ N ++ + N L+ + L L LH+N + +G
Sbjct: 53 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 112
Query: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
+ AF+ L +L + + +N L P LPR +R + NQ+ I F L +
Sbjct: 113 LPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV 172
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
L N++++ + DAFR + +L LS N+L LPP LP ++ L ++ N ++ + RG
Sbjct: 173 YLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRG 232
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYL 577
AL QLRELYL N+L L + L L+ LD++ NQLT +P GLP +L L+L
Sbjct: 233 ALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHL 292
Query: 578 QNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
N+I V A L+ + L+ N+L + A R L+ L L + GN
Sbjct: 293 GRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 345
Score = 137 bits (344), Expect = 4e-32
Identities = 98/304 (32%), Positives = 141/304 (46%), Gaps = 3/304 (0%)
Query: 135 LREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLT 194
L P LP L LQNN + K+ LSR +L L LQ+N+LT GL F L
Sbjct: 205 LSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLH 264
Query: 195 NLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADA 254
+L YL L++N+LT P LP L + N + ++ LR + L +N+L +
Sbjct: 265 SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 324
Query: 255 GLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRE 314
GLP + L L N L VP LP L L L +N + + L E
Sbjct: 325 GLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTE 384
Query: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
L L N L + + F +L +L LDL+ N L+R+P GLP L L L++N +R ++
Sbjct: 385 LNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEP 444
Query: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVH-LYNNALERVPSG--LPRRVR 431
L + L L L N+LR I P + L+ L H L ++ + R P LP V
Sbjct: 445 EPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAPPSPCLPCHVP 504
Query: 432 TLMI 435
+++
Sbjct: 505 NILV 508
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 456 bits (1174), Expect = e-128
Identities = 236/443 (53%), Positives = 305/443 (68%)
Query: 111 PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRL 170
P +CP C+C + VDC G+DLR FP ++ HLSLQNNQL+++ ELSRL L
Sbjct: 41 PLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGL 100
Query: 171 ETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKI 230
TLNL NN ++S GLP++AFE LT L +L +A+NKL++AP+FLP +L D AAN + +I
Sbjct: 101 RTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEI 160
Query: 231 YGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYK 290
+ LTFG+KP LRSVYLHNN+L++AGLP + F GS + L LS+N L ++P LPP+L +
Sbjct: 161 FPLTFGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLER 220
Query: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
LHL+NN + K+P GA S + LRELYLQ+N LTD GLD TF KL SLEYLDLS N L+
Sbjct: 221 LHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 280
Query: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
VPAGLPR+L +LHL +N IR V+A L R L YLLL NQL G+ A + L+ LH
Sbjct: 281 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 340
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
T+HLY N L+RVP LPRR+R L++ HN + +G D T L ELNL+YNR+ S +VH
Sbjct: 341 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 400
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
AFR+LR LRSLDL+GN+L LP GLP + L+++RN+L L L G+ QLREL L
Sbjct: 401 HRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 460
Query: 531 TSNRLRSRALGPRAWVDLAHLQL 553
NRLR +GP W +L LQ+
Sbjct: 461 AHNRLRVGDIGPGTWHELQALQV 483
Score = 206 bits (524), Expect = 6e-53
Identities = 130/354 (36%), Positives = 188/354 (53%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
LR P ++ A L L+NN+L+++P S LS LR L L NN ++ EGL +E F L+
Sbjct: 65 LRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLT 124
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
L++L ++ N LS P LPRSL + L N + + +L + LH+NQL
Sbjct: 125 QLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNA 184
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
G+ P AF+G + + T+ L NN L +P LP + L + +N I+ + R + L E
Sbjct: 185 GLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRE 244
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
L L +N++T + F KL L LDLS N+L T+P GLPR + +L + RN + +
Sbjct: 245 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 304
Query: 517 GALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLY 576
L G LR L L N+L S L A L L L + GN L +P LP L L
Sbjct: 305 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 364
Query: 577 LQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L +N ++A+ A +TP L + L +N+LA V AFRRL+ L+ LD+ GN
Sbjct: 365 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 418
Score = 147 bits (372), Expect = 2e-35
Identities = 93/293 (31%), Positives = 149/293 (50%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
++ +D +L P + R+ L L+ N ++ + N L+ + L L LH+N + +G
Sbjct: 55 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 114
Query: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
+ AF+ L +L + + +N L P LPR +R + NQ+ I F L +
Sbjct: 115 LPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV 174
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
L N++++ + DAFR + +L LS N+L LPP LP ++ L ++ N ++ + RG
Sbjct: 175 YLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRG 234
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYL 577
AL QLRELYL N+L L + L L+ LD++ NQLT +P GLP +L L+L
Sbjct: 235 ALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHL 294
Query: 578 QNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
N+I V A L+ + L+ N+L + A R L+ L L + GN
Sbjct: 295 GRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 347
Score = 137 bits (344), Expect = 4e-32
Identities = 98/304 (32%), Positives = 141/304 (46%), Gaps = 3/304 (0%)
Query: 135 LREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLT 194
L P LP L LQNN + K+ LSR +L L LQ+N+LT GL F L
Sbjct: 207 LSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLH 266
Query: 195 NLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADA 254
+L YL L++N+LT P LP L + N + ++ LR + L +N+L +
Sbjct: 267 SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSS 326
Query: 255 GLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRE 314
GLP + L L N L VP LP L L L +N + + L E
Sbjct: 327 GLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTE 386
Query: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
L L N L + + F +L +L LDL+ N L+R+P GLP L L L++N +R ++
Sbjct: 387 LNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEP 446
Query: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVH-LYNNALERVPSG--LPRRVR 431
L + L L L N+LR I P + L+ L H L ++ + R P LP V
Sbjct: 447 EPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRHRLVSHTVPRAPPSPCLPCHVP 506
Query: 432 TLMI 435
+++
Sbjct: 507 NILV 510
>gi|226342935 podocan-like 1 isoform 3 [Homo sapiens]
Length = 421
Score = 294 bits (752), Expect = 2e-79
Identities = 178/443 (40%), Positives = 232/443 (52%), Gaps = 89/443 (20%)
Query: 111 PAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRL 170
P +CP C+C + VDC G+DLR FP ++ HLS
Sbjct: 39 PLPRACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLS-------------------- 78
Query: 171 ETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKI 230
LQNN+L + N L+++
Sbjct: 79 ----LQNNQLQ---------------------------------------ELPYNELSRL 95
Query: 231 YGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYK 290
GL R++ LHNN ++ GLPD F + ++ L ++ N
Sbjct: 96 SGL--------RTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHN--------------- 132
Query: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
KNN + K+P GA S + LRELYLQ+N LTD GLD TF KL SLEYLDLS N L+
Sbjct: 133 ---KNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTT 189
Query: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
VPAGLPR+L +LHL +N IR V+A L R L YLLL NQL G+ A + L+ LH
Sbjct: 190 VPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLH 249
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
T+HLY N L+RVP LPRR+R L++ HN + +G D T L ELNL+YNR+ S +VH
Sbjct: 250 TLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVH 309
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
AFR+LR LRSLDL+GN+L LP GLP + L+++RN+L L L G+ QLREL L
Sbjct: 310 HRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSL 369
Query: 531 TSNRLRSRALGPRAWVDLAHLQL 553
NRLR +GP W +L LQ+
Sbjct: 370 AHNRLRVGDIGPGTWHELQALQV 392
Score = 175 bits (443), Expect = 1e-43
Identities = 120/348 (34%), Positives = 169/348 (48%), Gaps = 18/348 (5%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
LR P ++ A L L+NN+L+++P S LS LR L L NN ++ EGL +E F L+
Sbjct: 63 LRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLT 122
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
L++L ++ N + N I V L+ L L L NQL +
Sbjct: 123 QLQHLCVAHN------------------KNNLISKVPRGALSRQTQLRELYLQHNQLTDS 164
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
G+ F L L + L +N L VP+GLPR + L + N+I + L
Sbjct: 165 GLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAARLHGARGLRY 224
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
L L +N++ S + A R LR L +L L GN L +PP LPR + L + N +AAL
Sbjct: 225 LLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGA 284
Query: 517 GALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLY 576
LV L EL L NRL S + RA+ L L+ LD+AGNQLT +P GLP L L
Sbjct: 285 RDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQ 344
Query: 577 LQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQV 624
LQ N++ + L+ + L N+L VG + + L+ LQV
Sbjct: 345 LQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQV 392
Score = 135 bits (339), Expect = 2e-31
Identities = 99/299 (33%), Positives = 144/299 (48%), Gaps = 30/299 (10%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
++ +D +L P + R+ L L+ N ++ + N L+ + L L LH+N + +G
Sbjct: 53 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 112
Query: 398 IHPLAFQGLKRLH---TVHLYNNALERVPSGLPRR---VRTLMILHNQITGIGREDFATT 451
+ AF+ L +L H NN + +VP G R +R L + HNQ+T G + ATT
Sbjct: 113 LPDEAFESLTQLQHLCVAHNKNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLD--ATT 170
Query: 452 YFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNEL 511
F KL L LDLS N+L T+P GLPR + +L + RN +
Sbjct: 171 ----------------------FSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRI 208
Query: 512 AALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES 571
+ L G LR L L N+L S L A L L L + GN L +P LP
Sbjct: 209 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 268
Query: 572 LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L L L +N ++A+ A +TP L + L +N+LA V AFRRL+ L+ LD+ GN
Sbjct: 269 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGN 327
Score = 41.6 bits (96), Expect = 0.002
Identities = 26/98 (26%), Positives = 44/98 (44%)
Query: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
+D G L P+ + + ++L LQNN++ +P N L+ + L N ++ + D
Sbjct: 56 VDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPD 115
Query: 614 SAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKEEEE 651
AF L LQ L + N RG L ++ + E
Sbjct: 116 EAFESLTQLQHLCVAHNKNNLISKVPRGALSRQTQLRE 153
>gi|41349454 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 149 bits (375), Expect = 1e-35
Identities = 103/324 (31%), Positives = 162/324 (50%), Gaps = 24/324 (7%)
Query: 88 PEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQE--GVVDCGGIDLREFPGDLPEH 145
P+ +E AE P + P PGP CPR+C C + + C +LR+ P +P
Sbjct: 47 PQPDEPAE--PTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPR 103
Query: 146 TNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNK 205
++L LQNN + ++ E L +NL NNR+ R + ++ E L L +LY+ N+
Sbjct: 104 IHYLYLQNNFITELPVESFQNATGLRWINLDNNRI--RKIDQRVLEKLPGLVFLYMEKNQ 161
Query: 206 LTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L P LP L + + N++++I F + NL + L +N+L+D + F+G
Sbjct: 162 LEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLK 221
Query: 266 NVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDE 325
N+ L L+ N LR +P +P A+++L+L +NK+E IP G F +L + L N LTD
Sbjct: 222 NLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDR 281
Query: 326 GLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTP------ 379
GL +F +S+L L LS N +S VPA + L L+L N+I ++ + P
Sbjct: 282 GLPKNSF-NISNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKINGTQICPNDLVAF 339
Query: 380 ---------IRSLEYLLLHSNQLR 394
+ L YL L N L+
Sbjct: 340 HDFSSDLENVPHLRYLRLDGNYLK 363
Score = 108 bits (270), Expect = 2e-23
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 69/352 (19%)
Query: 279 HVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSL 338
+ P P ALY K+ IPP + LYLQNN++T+ L E+F + L
Sbjct: 78 YCPPDFPSALYCDSRNLRKVPVIPP-------RIHYLYLQNNFITE--LPVESFQNATGL 128
Query: 339 EYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGI 398
+++ L+ N IR +D VL + L +L + NQL E
Sbjct: 129 RWIN---------------------LDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEE--- 164
Query: 399 HPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELN 458
VPS LPR + L + N I+ I F+ L L+
Sbjct: 165 -----------------------VPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLD 201
Query: 459 LSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGA 518
L +NR++ D F L+ L L+L+ N L +PP +P +H L + N++ + G
Sbjct: 202 LQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGY 261
Query: 519 LVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQ 578
L + L N+L R L P+ ++++L +L ++ N+++ +P + LE+LYL
Sbjct: 262 FKSFPNLAFIRLNYNKLTDRGL-PKNSFNISNLLVLHLSHNRISSVP-AINNRLEHLYLN 319
Query: 579 NNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
NN I + N PN F F+ S + HL+ L ++GN
Sbjct: 320 NNSIEKI--NGTQICPNDLVAFHDFS---------SDLENVPHLRYLRLDGN 360
Score = 107 bits (268), Expect = 3e-23
Identities = 72/225 (32%), Positives = 117/225 (52%), Gaps = 4/225 (1%)
Query: 270 LILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDN 329
L S LR VP +PP ++ L+L+NN + ++P +F + LR + L NN + +D
Sbjct: 87 LYCDSRNLRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQ 143
Query: 330 ETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLH 389
KL L +L + N L VP+ LPR+L L L +N I + V + + +L L L
Sbjct: 144 RVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQ 203
Query: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFA 449
N+L + P F GLK L ++L +N L ++P +P + L + N+I I F
Sbjct: 204 HNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFK 263
Query: 450 TTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP 494
+ L + L+YN++T + +++F LL L LS NR+ ++P
Sbjct: 264 SFPNLAFIRLNYNKLTDRGLPKNSFNISNLL-VLHLSHNRISSVP 307
Score = 68.2 bits (165), Expect = 2e-11
Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 2/137 (1%)
Query: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
P +P +H L ++ N + L + LR + L +NR+R + R L L L
Sbjct: 98 PVIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFL 155
Query: 555 DIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDS 614
+ NQL E+P LP +LE L L N IS +P F NL + L+ N+L+ G
Sbjct: 156 YMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPD 215
Query: 615 AFRRLKHLQVLDIEGNL 631
F LK+L L++ N+
Sbjct: 216 TFHGLKNLMQLNLAHNI 232
>gi|4506041 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 149 bits (375), Expect = 1e-35
Identities = 103/324 (31%), Positives = 162/324 (50%), Gaps = 24/324 (7%)
Query: 88 PEENEFAEEEPVLVLSPEEPGPGPAAVSCPRDCACSQE--GVVDCGGIDLREFPGDLPEH 145
P+ +E AE P + P PGP CPR+C C + + C +LR+ P +P
Sbjct: 47 PQPDEPAE--PTDLPPPLPPGPPSIFPDCPRECYCPPDFPSALYCDSRNLRKVPV-IPPR 103
Query: 146 TNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNK 205
++L LQNN + ++ E L +NL NNR+ R + ++ E L L +LY+ N+
Sbjct: 104 IHYLYLQNNFITELPVESFQNATGLRWINLDNNRI--RKIDQRVLEKLPGLVFLYMEKNQ 161
Query: 206 LTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L P LP L + + N++++I F + NL + L +N+L+D + F+G
Sbjct: 162 LEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLK 221
Query: 266 NVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDE 325
N+ L L+ N LR +P +P A+++L+L +NK+E IP G F +L + L N LTD
Sbjct: 222 NLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDR 281
Query: 326 GLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTP------ 379
GL +F +S+L L LS N +S VPA + L L+L N+I ++ + P
Sbjct: 282 GLPKNSF-NISNLLVLHLSHNRISSVPA-INNRLEHLYLNNNSIEKINGTQICPNDLVAF 339
Query: 380 ---------IRSLEYLLLHSNQLR 394
+ L YL L N L+
Sbjct: 340 HDFSSDLENVPHLRYLRLDGNYLK 363
Score = 108 bits (270), Expect = 2e-23
Identities = 94/352 (26%), Positives = 150/352 (42%), Gaps = 69/352 (19%)
Query: 279 HVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSL 338
+ P P ALY K+ IPP + LYLQNN++T+ L E+F + L
Sbjct: 78 YCPPDFPSALYCDSRNLRKVPVIPP-------RIHYLYLQNNFITE--LPVESFQNATGL 128
Query: 339 EYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGI 398
+++ L+ N IR +D VL + L +L + NQL E
Sbjct: 129 RWIN---------------------LDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEE--- 164
Query: 399 HPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELN 458
VPS LPR + L + N I+ I F+ L L+
Sbjct: 165 -----------------------VPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLD 201
Query: 459 LSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGA 518
L +NR++ D F L+ L L+L+ N L +PP +P +H L + N++ + G
Sbjct: 202 LQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGY 261
Query: 519 LVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQ 578
L + L N+L R L P+ ++++L +L ++ N+++ +P + LE+LYL
Sbjct: 262 FKSFPNLAFIRLNYNKLTDRGL-PKNSFNISNLLVLHLSHNRISSVP-AINNRLEHLYLN 319
Query: 579 NNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
NN I + N PN F F+ S + HL+ L ++GN
Sbjct: 320 NNSIEKI--NGTQICPNDLVAFHDFS---------SDLENVPHLRYLRLDGN 360
Score = 107 bits (268), Expect = 3e-23
Identities = 72/225 (32%), Positives = 117/225 (52%), Gaps = 4/225 (1%)
Query: 270 LILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDN 329
L S LR VP +PP ++ L+L+NN + ++P +F + LR + L NN + +D
Sbjct: 87 LYCDSRNLRKVPV-IPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQ 143
Query: 330 ETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLH 389
KL L +L + N L VP+ LPR+L L L +N I + V + + +L L L
Sbjct: 144 RVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQ 203
Query: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFA 449
N+L + P F GLK L ++L +N L ++P +P + L + N+I I F
Sbjct: 204 HNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQLYLDSNKIETIPNGYFK 263
Query: 450 TTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP 494
+ L + L+YN++T + +++F LL L LS NR+ ++P
Sbjct: 264 SFPNLAFIRLNYNKLTDRGLPKNSFNISNLL-VLHLSHNRISSVP 307
Score = 68.2 bits (165), Expect = 2e-11
Identities = 44/137 (32%), Positives = 66/137 (48%), Gaps = 2/137 (1%)
Query: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
P +P +H L ++ N + L + LR + L +NR+R + R L L L
Sbjct: 98 PVIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNNRIRK--IDQRVLEKLPGLVFL 155
Query: 555 DIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDS 614
+ NQL E+P LP +LE L L N IS +P F NL + L+ N+L+ G
Sbjct: 156 YMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPD 215
Query: 615 AFRRLKHLQVLDIEGNL 631
F LK+L L++ N+
Sbjct: 216 TFHGLKNLMQLNLAHNI 232
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 146 bits (368), Expect = 7e-35
Identities = 136/441 (30%), Positives = 208/441 (47%), Gaps = 51/441 (11%)
Query: 106 EPGPGPAAVSCPRDCACSQEGVV---DCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPE 162
+PGPGP A CP C C ++G++ DC + L PGDL T +L L N L ++ P
Sbjct: 27 QPGPGPTA--CPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPG 84
Query: 163 ELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPR----FLPNALI 218
L LE L L N L+ +P +AF L +L L L NN+L P LP +L
Sbjct: 85 LFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGIPAEALWELP-SLQ 141
Query: 219 SVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLR 278
S+ AN ++ + +F +LR ++L +N L + +P N ++ + L+ N +
Sbjct: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPALQAMTLALNRIS 199
Query: 279 HVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKL 335
H+P + +L LHL NN+++ + +F L +L L L N L + + T L
Sbjct: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRT---L 256
Query: 336 SSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSN 391
L+ L +NN+ +P G P L +H N I+ V + + L L L+
Sbjct: 257 GRLQELGFHNNNIKAIPEKAFMGNP-LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGA 315
Query: 392 Q------------------LREQGIHPL---AFQGLKRLHTVHLYNNALERVPS-GLPRR 429
L GI L Q L RL + L +N +E +PS ++
Sbjct: 316 MDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQK 375
Query: 430 VRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNR 489
+ + + HN+I IG + F+ L+ L+LS+N I S +H +AF L L LDL+ N+
Sbjct: 376 LEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQ 433
Query: 490 LHTLP-PGLPRNVHVLKVKRN 509
L TLP GL +H LK+K N
Sbjct: 434 LTTLPLAGLGGLMH-LKLKGN 453
Score = 110 bits (274), Expect = 5e-24
Identities = 118/425 (27%), Positives = 198/425 (46%), Gaps = 45/425 (10%)
Query: 206 LTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L+ P L +D + N LT++ F L + L N L+ +P F+G
Sbjct: 57 LSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLY 114
Query: 266 NVEVLILSSNFLRHVPKHLP---PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
++++L+L +N L +P P+L L L N + +P +F LSSLR L+L +N L
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNAL 174
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKNAIRSVDANVLTP 379
T+ + L +L+ + L+ N +S +P + SLV+LHL N I+ + +
Sbjct: 175 TE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEG 232
Query: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPS----GLPRRVRTLMI 435
+ +LE L L+ N+L+E P+A + L RL + +NN ++ +P G P ++T+
Sbjct: 233 LHNLETLDLNYNKLQE---FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPL-LQTIHF 288
Query: 436 LHNQITGIGREDFATTYFLEELNLS----------YNRITSPQVHRDAFRKLRLL----- 480
N I +GR F L L+L+ TS ++ +RLL
Sbjct: 289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 348
Query: 481 ------RSLDLSGNRLHTLPPGLPR--NVHVLKVKRNELAALARGALVGMAQLRELYLTS 532
R L+LS N++ LP L R + + ++ N + + ++ L+ L L+
Sbjct: 349 QQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 407
Query: 533 NRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDS 592
N +RS + P A+ L L LD+ NQLT +P L +L L+ N ++ A + DS
Sbjct: 408 NAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN-LALSQAFSKDS 464
Query: 593 TPNLK 597
P L+
Sbjct: 465 FPKLR 469
Score = 78.6 bits (192), Expect = 2e-14
Identities = 81/271 (29%), Positives = 121/271 (44%), Gaps = 18/271 (6%)
Query: 385 YLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP----SGLPRRVRTLMILHNQI 440
YL L N L E + P F L+ L + L N L +P SGL ++ LM+ +NQ+
Sbjct: 70 YLDLSMNNLTE--LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGL-YSLKILMLQNNQL 126
Query: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500
GI E L+ L L N I+ V +F L LR L L N L +P N
Sbjct: 127 GGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
Query: 501 VHVLKVKR---NELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIA 557
+ L+ N ++ + A + L L+L +NR++ LG ++ L +L+ LD+
Sbjct: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQH--LGTHSFEGLHNLETLDLN 242
Query: 558 GNQLTEIPEGLPE--SLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSA 615
N+L E P + L+ L NN I A+P AF P L+ I N + V SA
Sbjct: 243 YNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQF--VGRSA 300
Query: 616 FRRLKHLQVLDIEGNLEFGDISKDRGRLGKE 646
F+ L L L + G ++ + +G E
Sbjct: 301 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLE 331
Score = 70.1 bits (170), Expect = 6e-12
Identities = 67/219 (30%), Positives = 105/219 (47%), Gaps = 15/219 (6%)
Query: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478
L VP L L + N +T + F FLEEL LS N ++ + AF L
Sbjct: 57 LSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS--HIPGQAFSGLY 114
Query: 479 LLRSLDLSGNRLHTLPPG----LPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNR 534
L+ L L N+L +P LP ++ L++ N ++ + + G++ LR L+L N
Sbjct: 115 SLKILMLQNNQLGGIPAEALWELP-SLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNA 173
Query: 535 LRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE---SLEYLYLQNNKISAVPANAFD 591
L + RA +L LQ + +A N+++ IP+ + SL L+L NN+I + ++F+
Sbjct: 174 LTE--IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 231
Query: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
NL+ + L +NKL V A R L LQ L N
Sbjct: 232 GLHNLETLDLNYNKLQEFPV---AIRTLGRLQELGFHNN 267
Score = 43.5 bits (101), Expect = 6e-04
Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 7/125 (5%)
Query: 510 ELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP---- 565
+ + L A+ G YL + L P + L L+ L ++GN L+ IP
Sbjct: 51 DCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAF 110
Query: 566 EGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVL 625
GL SL+ L LQNN++ +PA A P+L+ + L N +++ V + +F L L+ L
Sbjct: 111 SGL-YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHL 167
Query: 626 DIEGN 630
++ N
Sbjct: 168 WLDDN 172
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 145 bits (366), Expect = 1e-34
Identities = 135/462 (29%), Positives = 207/462 (44%), Gaps = 45/462 (9%)
Query: 99 VLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEK 158
+L++ + G G A CP +C CS+ V+C G + P LP + L + N + +
Sbjct: 14 LLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITE 73
Query: 159 IYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALI 218
+ + L L ++ N L+ + AF +L +L YL LANNKL + P L L
Sbjct: 74 LNESPFLNISALIALRIEKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 131
Query: 219 SVD---FAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSN 275
S++ ++N L +I F Q NL+ + LH N L +PD F+
Sbjct: 132 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL--EYIPDGAFD------------- 176
Query: 276 FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKL 335
HL L KL+L N L I P F L +L+ L L N LTD + TF L
Sbjct: 177 -------HL-VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD--IPMGTFDGL 226
Query: 336 SSLEYLDLSSNNLSRVPAGL---PRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQ 392
+L+ L L N + + GL +L L+L N I + ++ + L L L N
Sbjct: 227 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 286
Query: 393 LREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGREDFA 449
L+E + F + L + LY+N + +P + +R L +L NQI+ I F
Sbjct: 287 LKELSLG--IFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 344
Query: 450 TTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVH---VLKV 506
L EL+L N + + + FR L L+++ L NRL LP + NV+ +++
Sbjct: 345 GLTELRELSLHTNAL--QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQL 402
Query: 507 KRNELAALARGALVGMAQLRELYLTSN--RLRSRALGPRAWV 546
+ N+L L G + +L EL L N R S L R W+
Sbjct: 403 QNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444
Score = 111 bits (277), Expect = 2e-24
Identities = 108/339 (31%), Positives = 161/339 (47%), Gaps = 40/339 (11%)
Query: 287 ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSN 346
AL L ++ N+L +I PGAF L SLR L L NN L + L F L SLE L LSSN
Sbjct: 84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QVLPIGLFQGLDSLESLLLSSN 141
Query: 347 NLSRV-PAGLPR--SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403
L ++ PA + +L L L N + + + L L L N L I P F
Sbjct: 142 QLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH--ISPRVF 199
Query: 404 QGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTYFLEELNLS 460
Q L L + LY N L +P G ++ L + NQI + F + L+ L LS
Sbjct: 200 QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLS 259
Query: 461 YNRITS---------PQVHR-----DAFRKLRL--------LRSLDLSGNRLHTLPPGLP 498
N I+ PQ++R ++ ++L L LR L L N + +LP +
Sbjct: 260 NNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVF 319
Query: 499 RNVHVLKV---KRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLD 555
N+ L+V RN+++ ++ GA G+ +LREL L +N L+ L + LA+LQ +
Sbjct: 320 SNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNIS 377
Query: 556 IAGNQLTEIPEGL---PESLEYLYLQNNKISAVPANAFD 591
+ N+L ++P + L + LQNN++ +P FD
Sbjct: 378 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 416
Score = 73.2 bits (178), Expect = 7e-13
Identities = 83/323 (25%), Positives = 133/323 (41%), Gaps = 55/323 (17%)
Query: 336 SSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE 395
S ++ + + VP LP + + L + I ++ + I +L L + N+L
Sbjct: 38 SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSR 97
Query: 396 QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTY 452
I P AF+ L L + L NN L+ +P GL + + +L++ NQ+ I F+
Sbjct: 98 --ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCS 155
Query: 453 FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPR---NVHVLKVKRN 509
L+EL L N + + AF L L L+L N L + P + + N+ VL++ N
Sbjct: 156 NLKELQLHGNHLE--YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 213
Query: 510 ELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLP 569
L + G G+ L+EL L N++ + G L H
Sbjct: 214 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPG------LFHNN----------------- 250
Query: 570 ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA---------------------- 607
+L+ LYL NN IS +P + F P L + L N L
Sbjct: 251 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 310
Query: 608 VGSVVDSAFRRLKHLQVLDIEGN 630
+ S+ D+ F L+ LQVL + N
Sbjct: 311 ISSLPDNVFSNLRQLQVLILSRN 333
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 145 bits (366), Expect = 1e-34
Identities = 135/462 (29%), Positives = 207/462 (44%), Gaps = 45/462 (9%)
Query: 99 VLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEK 158
+L++ + G G A CP +C CS+ V+C G + P LP + L + N + +
Sbjct: 8 LLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITE 67
Query: 159 IYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALI 218
+ + L L ++ N L+ + AF +L +L YL LANNKL + P L L
Sbjct: 68 LNESPFLNISALIALRIEKNELSR--ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLD 125
Query: 219 SVD---FAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSN 275
S++ ++N L +I F Q NL+ + LH N L +PD F+
Sbjct: 126 SLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHL--EYIPDGAFD------------- 170
Query: 276 FLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKL 335
HL L KL+L N L I P F L +L+ L L N LTD + TF L
Sbjct: 171 -------HL-VGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD--IPMGTFDGL 220
Query: 336 SSLEYLDLSSNNLSRVPAGL---PRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQ 392
+L+ L L N + + GL +L L+L N I + ++ + L L L N
Sbjct: 221 VNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNS 280
Query: 393 LREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGREDFA 449
L+E + F + L + LY+N + +P + +R L +L NQI+ I F
Sbjct: 281 LKELSLG--IFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 338
Query: 450 TTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVH---VLKV 506
L EL+L N + + + FR L L+++ L NRL LP + NV+ +++
Sbjct: 339 GLTELRELSLHTNAL--QDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQL 396
Query: 507 KRNELAALARGALVGMAQLRELYLTSN--RLRSRALGPRAWV 546
+ N+L L G + +L EL L N R S L R W+
Sbjct: 397 QNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438
Score = 111 bits (277), Expect = 2e-24
Identities = 108/339 (31%), Positives = 161/339 (47%), Gaps = 40/339 (11%)
Query: 287 ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSN 346
AL L ++ N+L +I PGAF L SLR L L NN L + L F L SLE L LSSN
Sbjct: 78 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QVLPIGLFQGLDSLESLLLSSN 135
Query: 347 NLSRV-PAGLPR--SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403
L ++ PA + +L L L N + + + L L L N L I P F
Sbjct: 136 QLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTH--ISPRVF 193
Query: 404 QGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTYFLEELNLS 460
Q L L + LY N L +P G ++ L + NQI + F + L+ L LS
Sbjct: 194 QHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLS 253
Query: 461 YNRITS---------PQVHR-----DAFRKLRL--------LRSLDLSGNRLHTLPPGLP 498
N I+ PQ++R ++ ++L L LR L L N + +LP +
Sbjct: 254 NNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVF 313
Query: 499 RNVHVLKV---KRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLD 555
N+ L+V RN+++ ++ GA G+ +LREL L +N L+ L + LA+LQ +
Sbjct: 314 SNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQD--LDGNVFRMLANLQNIS 371
Query: 556 IAGNQLTEIPEGL---PESLEYLYLQNNKISAVPANAFD 591
+ N+L ++P + L + LQNN++ +P FD
Sbjct: 372 LQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFD 410
Score = 73.2 bits (178), Expect = 7e-13
Identities = 83/323 (25%), Positives = 133/323 (41%), Gaps = 55/323 (17%)
Query: 336 SSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE 395
S ++ + + VP LP + + L + I ++ + I +L L + N+L
Sbjct: 32 SRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSR 91
Query: 396 QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTY 452
I P AF+ L L + L NN L+ +P GL + + +L++ NQ+ I F+
Sbjct: 92 --ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCS 149
Query: 453 FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPR---NVHVLKVKRN 509
L+EL L N + + AF L L L+L N L + P + + N+ VL++ N
Sbjct: 150 NLKELQLHGNHLE--YIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN 207
Query: 510 ELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLP 569
L + G G+ L+EL L N++ + G L H
Sbjct: 208 RLTDIPMGTFDGLVNLQELALQQNQIGLLSPG------LFHNN----------------- 244
Query: 570 ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA---------------------- 607
+L+ LYL NN IS +P + F P L + L N L
Sbjct: 245 HNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH 304
Query: 608 VGSVVDSAFRRLKHLQVLDIEGN 630
+ S+ D+ F L+ LQVL + N
Sbjct: 305 ISSLPDNVFSNLRQLQVLILSRN 327
>gi|5901992 keratocan [Homo sapiens]
Length = 352
Score = 145 bits (365), Expect = 2e-34
Identities = 99/295 (33%), Positives = 150/295 (50%), Gaps = 19/295 (6%)
Query: 116 CPRDCAC--SQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETL 173
CP +C C S + C L+E P +P +L LQNN +E I + +L +
Sbjct: 42 CPMECFCPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWI 100
Query: 174 NLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGL 233
NL N++T+ G+ + A L L +L+L +N+L P LP +L + A N +++I
Sbjct: 101 NLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG 160
Query: 234 TFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHL 293
TF NL + L NNKL D + F G N+ L ++ N LR++P LP +L L
Sbjct: 161 TFSNLENLTLLDLQNNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFL 220
Query: 294 KNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPA 353
NN +E IP F+ + + L L +N L+DEGL + F +SS+ L LS N L++VP
Sbjct: 221 DNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGF-DVSSILDLQLSHNQLTKVPR 279
Query: 354 GLPRSLVLLHLEKNAIRSVDANVLTPIRS--------------LEYLLLHSNQLR 394
+ L LHL+ N I+SV+ +V+ P S L YL L N+++
Sbjct: 280 -ISAHLQHLHLDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHLRYLRLDGNEIK 333
Score = 112 bits (280), Expect = 1e-24
Identities = 71/252 (28%), Positives = 128/252 (50%), Gaps = 3/252 (1%)
Query: 345 SNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQ 404
+ L +PA +P + L+L+ N I ++ L ++ L+ N++ GI A
Sbjct: 60 NRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALS 118
Query: 405 GLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRI 464
LK+L + L +N LE VPS LPR + L + N+++ I + F+ L L+L N++
Sbjct: 119 QLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKL 178
Query: 465 TSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQ 524
RD F+ L+ L L+++ N L +PP LP N L + N + + + +
Sbjct: 179 VDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPK 238
Query: 525 LRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISA 584
+ L L N+L L R + D++ + L ++ NQLT++P + L++L+L +NKI +
Sbjct: 239 VAFLRLNHNKLSDEGLPSRGF-DVSSILDLQLSHNQLTKVPR-ISAHLQHLHLDHNKIKS 296
Query: 585 VPANAFDSTPNL 596
V + +P++
Sbjct: 297 VNVSVICPSPSM 308
Score = 110 bits (276), Expect = 3e-24
Identities = 86/304 (28%), Positives = 132/304 (43%), Gaps = 39/304 (12%)
Query: 199 LYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPD 258
LY N L P +P+ + + N + I F LR + L+ NK+ + G+
Sbjct: 56 LYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEK 114
Query: 259 NMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQ 318
+ + L L N L VP LP +L +L L NK+ +IP G FS L +L L LQ
Sbjct: 115 GALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQ 174
Query: 319 NNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLT 378
NN L D +TF L +L L+++ N L +P LP + + L L+ N+I + N
Sbjct: 175 NNKLVDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFN 234
Query: 379 PIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHN 438
I + +L L+ N+L ++G+ F + L + HN
Sbjct: 235 VIPKVAFLRLNHNKLSDEGLPSRGFD----------------------VSSILDLQLSHN 272
Query: 439 QITGIGREDFATTYFLEELNLSYNRITSPQV------------HRDAFRKLRLLRSLDLS 486
Q+T + R + L+ L+L +N+I S V RD+F LR L L
Sbjct: 273 QLTKVPR----ISAHLQHLHLDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHLRYLRLD 328
Query: 487 GNRL 490
GN +
Sbjct: 329 GNEI 332
Score = 96.3 bits (238), Expect = 8e-20
Identities = 59/192 (30%), Positives = 100/192 (52%), Gaps = 1/192 (0%)
Query: 416 NNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFR 475
N L+ +P+ +P R+ L + +N I I + F L +NL+ N+IT+ + + A
Sbjct: 60 NRGLKEIPA-IPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALS 118
Query: 476 KLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRL 535
+L+ L L L N L +P LPR++ L++ RN+++ + +G + L L L +N+L
Sbjct: 119 QLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKL 178
Query: 536 RSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPN 595
A + L +L L++A N L +P LP + L+L NN I +P N F+ P
Sbjct: 179 VDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPK 238
Query: 596 LKGIFLRFNKLA 607
+ + L NKL+
Sbjct: 239 VAFLRLNHNKLS 250
Score = 69.3 bits (168), Expect = 1e-11
Identities = 41/136 (30%), Positives = 65/136 (47%)
Query: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
P +P + L ++ N + + QLR + L N++ + + A L L L
Sbjct: 67 PAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFL 126
Query: 555 DIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDS 614
+ N+L E+P LP SLE L L NK+S +P F + NL + L+ NKL +
Sbjct: 127 FLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDNAFQRD 186
Query: 615 AFRRLKHLQVLDIEGN 630
F+ LK+L L++ N
Sbjct: 187 TFKGLKNLMQLNMAKN 202
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 143 bits (360), Expect = 6e-34
Identities = 105/350 (30%), Positives = 170/350 (48%), Gaps = 11/350 (3%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
L +P P + L L N + IP AF+ L +L L L N +T G+ + F L
Sbjct: 334 LTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLK 393
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
L L++ NNL ++P+ LP +L L + +N ++++D L+ + L L L N L E
Sbjct: 394 KLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEA 453
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
++PLAF+ LK L + L N +P GLP + L + +NQI I F T +
Sbjct: 454 NVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINV 513
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
+ L YN+I ++ A+ L S+DLS N+L+ +P LP+++ L + N++ +
Sbjct: 514 IVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIP- 572
Query: 517 GALVGMAQ--LRELYLTSNRLRSRALGPRAWVDLAH-LQLLDIAGNQLTEIPEGLPE--S 571
G + G + L LYL+ N+L + ++ H L+ L + N L IP G+ E +
Sbjct: 573 GYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKA 632
Query: 572 LEYLYLQNNKISAVPANAF-----DSTPNLKGIFLRFNKLAVGSVVDSAF 616
L +L L NNKI + D NL+ + L N + + + F
Sbjct: 633 LHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTF 682
Score = 136 bits (342), Expect = 7e-32
Identities = 112/404 (27%), Positives = 173/404 (42%), Gaps = 44/404 (10%)
Query: 203 NNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
N LT P + S++ N + I F PNL + L N + +G+ F
Sbjct: 331 NAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFK 390
Query: 263 GSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
+ L + N L +P LP L +L + N L+ I + S+L+ L L L+ N L
Sbjct: 391 LLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNL 450
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRS 382
++ ++ F L SL YL L N +P GLP S+ L+LE N I + R
Sbjct: 451 SEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRK 510
Query: 383 LEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITG 442
+ ++L N++ E I PLA+ + L ++ L N L VPS LP+ + L++L NQI
Sbjct: 511 INVIVLRYNKIEENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIER 570
Query: 443 IGREDFA-TTYFLEELNLSYNRITSPQVHRDAF-RKLRLLRSLDLSGNRLHTLPPGLPRN 500
I F LE L LS+N++ + R +F LR L L N L ++PPG+
Sbjct: 571 IPGYVFGHMEPGLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQE- 629
Query: 501 VHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQ 560
M L L L +N++R +I +
Sbjct: 630 ---------------------MKALHFLRLNNNKIR------------------NILPEE 650
Query: 561 LTEIPEGLPESLEYLYLQNN--KISAVPANAFDSTPNLKGIFLR 602
+ E +LE+L+L+NN KI +P+ F + I L+
Sbjct: 651 ICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLK 694
Score = 134 bits (337), Expect = 3e-31
Identities = 116/412 (28%), Positives = 186/412 (45%), Gaps = 16/412 (3%)
Query: 89 EENEFAEEEPV---LVLSPEE---PGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDL 142
EE+E EE+PV + P P P + P C+ S + C L + P
Sbjct: 283 EEDEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGCSLSYR-TISCINAMLTQIPPLT 341
Query: 143 PEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLA 202
L L N + I E + L LE L+L N +TS G+ KAF+ L L L +
Sbjct: 342 APQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMD 401
Query: 203 NNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
N L P LP+ L + N L I + L ++ L N L++A + F
Sbjct: 402 GNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFK 461
Query: 263 GSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
++ L L N R +P+ LP ++ +L+L+NN++E+I F+ + + L+ N +
Sbjct: 462 PLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKI 521
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIR- 381
+ + + +LE +DLS N L VP+ LP+SL+ L L N I + V +
Sbjct: 522 EENRIAPLAWINQENLESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEP 581
Query: 382 SLEYLLLHSNQLREQGIHPLAFQG-LKRLHTVHLYNNALERVPSGLP--RRVRTLMILHN 438
LEYL L N+L + G+ ++F G L + L +N L+ +P G+ + + L + +N
Sbjct: 582 GLEYLYLSFNKLADDGMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNN 641
Query: 439 QITGIGREDFATT-----YFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDL 485
+I I E+ LE L+L N I ++ F +R S+ L
Sbjct: 642 KIRNILPEEICNAEEDDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVL 693
Score = 115 bits (288), Expect = 1e-25
Identities = 73/220 (33%), Positives = 111/220 (50%)
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
T+ N L ++P ++ +L + N I I E F LE L+LS N ITS +
Sbjct: 326 TISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIG 385
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
AF+ L+ L L++ GN L +P LP + LKV N L A+ +L + QL L L
Sbjct: 386 PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLEL 445
Query: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAF 590
N L + P A+ L L L + N+ IP+GLP S+E LYL+NN+I + F
Sbjct: 446 EGNNLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICF 505
Query: 591 DSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ T + I LR+NK+ + A+ ++L+ +D+ N
Sbjct: 506 NHTRKINVIVLRYNKIEENRIAPLAWINQENLESIDLSYN 545
Score = 93.6 bits (231), Expect = 5e-19
Identities = 67/222 (30%), Positives = 108/222 (48%), Gaps = 9/222 (4%)
Query: 136 REFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTN 195
R P LP L L+NNQ+E+I + ++ + L+ N++ + A+ + N
Sbjct: 477 RIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVIVLRYNKIEENRIAPLAWINQEN 536
Query: 196 LNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQ-KPNLRSVYLHNNKLADA 254
L + L+ NKL P +LP +L+ + N + +I G FG +P L +YL NKLAD
Sbjct: 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYVFGHMEPGLEYLYLSFNKLADD 596
Query: 255 GLPDNMFNGS-SNVEVLILSSNFLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSEL-- 309
G+ F G+ ++ L L N L+ +P + AL+ L L NNK+ I P
Sbjct: 597 GMDRVSFYGAYHSLRELFLDHNDLKSIPPGIQEMKALHFLRLNNNKIRNILPEEICNAEE 656
Query: 310 ---SSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNL 348
S+L L+L+NNY+ + + TF + S + L N+
Sbjct: 657 DDDSNLEHLHLENNYIKIREIPSYTFSCIRSYSSIVLKPQNI 698
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/150 (29%), Positives = 72/150 (48%)
Query: 481 RSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
R++ L +PP + L++ N +A++ A G+ L L L+ N + S +
Sbjct: 325 RTISCINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGI 384
Query: 541 GPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIF 600
GP+A+ L L L++ GN L +IP LP +LE L + N + A+ + L +
Sbjct: 385 GPKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLE 444
Query: 601 LRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L N L+ +V AF+ LK L L + N
Sbjct: 445 LEGNNLSEANVNPLAFKPLKSLAYLRLGKN 474
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 139 bits (351), Expect = 6e-33
Identities = 133/452 (29%), Positives = 203/452 (44%), Gaps = 47/452 (10%)
Query: 100 LVLSPEEPGPGPAAVSCPRDCACSQEGV----VDCGGIDLREFPGDLPEHTNHLSLQNNQ 155
L P G CP C C +G VDC + L E P +L T++L L N
Sbjct: 18 LATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNN 77
Query: 156 LEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAP-RFLP 214
+ ++ P L L LE L L N LT +P+ AF L +L L L NN+L P L
Sbjct: 78 ISQLLPNPLPSLRFLEELRLAGNALTY--IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
Query: 215 N--ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLIL 272
N +L S+ AN+++ + F +LR ++L +N L + +P F S ++ + L
Sbjct: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTE--IPVQAFRSLSALQAMTL 193
Query: 273 SSNFLRHVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDN 329
+ N + H+P + +L LHL NN++ + F L SL L L N L +
Sbjct: 194 ALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI 253
Query: 330 ETFWKLSSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEY 385
T LS+L+ L SNN+ +P G P SL+ +H N I+ V + + L
Sbjct: 254 RT---LSNLKELGFHSNNIRSIPEKAFVGNP-SLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 386 LLLH-SNQLRE-------QGIHPLAFQG-------------LKRLHTVHLYNNALERVPS 424
L L+ ++Q+ E + L G L L + L N LE +PS
Sbjct: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
Query: 425 -GLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
+ ++++ + + HN+I I + F L LNL++N+I +H +AF L L L
Sbjct: 370 FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKL 427
Query: 484 DLSGNRLHTLP-PGLPRNVHVLKVKRNELAAL 514
DLS N L + P GL H+ + L +L
Sbjct: 428 DLSSNLLSSFPITGLHGLTHLKLTGNHALQSL 459
Score = 107 bits (266), Expect = 5e-23
Identities = 115/414 (27%), Positives = 182/414 (43%), Gaps = 67/414 (16%)
Query: 252 ADAGLPDNMFNGSSNVEVLILSSNFLRHV-PKHLPPA--LYKLHLKNNKLEKIPPGAFSE 308
+D GL + N S L LS N + + P LP L +L L N L IP GAF+
Sbjct: 53 SDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTG 112
Query: 309 LSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNA 368
L SL+ L LQNN L + E L SL+ L L +N++S VP
Sbjct: 113 LYSLKVLMLQNNQLRH--VPTEALQNLRSLQSLRLDANHISYVPP--------------- 155
Query: 369 IRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR 428
+ + + SL +L L N L E + AF+ L L + L N + +P
Sbjct: 156 ------SCFSGLHSLRHLWLDDNALTEIPVQ--AFRSLSALQAMTLALNKIHHIPDYAFG 207
Query: 429 RVRTLMILH---NQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDL 485
+ +L++LH N+I +G++ F + LE L+L+YN + A R L L+ L
Sbjct: 208 NLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDE---FPTAIRTLSNLKELGF 264
Query: 486 SGNRLHTLPP----GLPRNVHVLKVKRNELAALARGA----------------------- 518
N + ++P G P + + N + + R A
Sbjct: 265 HSNNIRSIPEKAFVGNPSLI-TIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD 323
Query: 519 LVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPE-GLPESLEYLYL 577
L G A L L LT ++ S L L +LQ+LD++ N L ++P + + L+ + L
Sbjct: 324 LTGTANLESLTLTGAQISS--LPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDL 381
Query: 578 QNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNL 631
++N+I + + F +L+ + L +NK+A+ + +AF L L LD+ NL
Sbjct: 382 RHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKLDLSSNL 433
Score = 29.6 bits (65), Expect = 9.3
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 2/77 (2%)
Query: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
+D + L+E+P L YL L N IS + N S L+ + L N L +
Sbjct: 50 VDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTY--IPK 107
Query: 614 SAFRRLKHLQVLDIEGN 630
AF L L+VL ++ N
Sbjct: 108 GAFTGLYSLKVLMLQNN 124
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 139 bits (349), Expect = 1e-32
Identities = 165/552 (29%), Positives = 233/552 (42%), Gaps = 105/552 (19%)
Query: 102 LSPEEPG-PGPA-AVSCPRDCACSQEGVVD-----CGGIDLREFPGDLPEHTNHLSLQNN 154
L +PG PG A +CP C CS + D C +L P +P T L L N
Sbjct: 63 LEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 122
Query: 155 QLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLP 214
L + P L L LNLQ +L S L +A L NL +L+L N+L R L
Sbjct: 123 NLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENLCHLHLERNQL----RSLA 176
Query: 215 NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSS 274
TF P L S+ L NN+L+ L D +F G +
Sbjct: 177 LG-----------------TFAHTPALASLGLSNNRLSR--LEDGLFEGLGS-------- 209
Query: 275 NFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWK 334
L+ L+L N L +P AF L SLREL L N L L F
Sbjct: 210 -------------LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSG 254
Query: 335 LSSLEYLDLSSNNLSRVPAG----LPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHS 390
L+ L LDLS N L + A LPR L L+L++N I +V +++L +L L
Sbjct: 255 LAELRELDLSRNALRAIKANVFVQLPR-LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 313
Query: 391 NQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL------HNQITGIG 444
N R G+ F GL L + L +NA + S PR + L L HN+I +
Sbjct: 314 N--RVAGLLEDTFPGLLGLRVLRLSHNA---IASLRPRTFKDLHFLEELQLGHNRIRQLA 368
Query: 445 REDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP------GLP 498
F LE L L +N++ +V AF L + ++LSGN L LP G
Sbjct: 369 ERSFEGLGQLEVLTLDHNQLQ--EVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 426
Query: 499 RNVHV---------------------LKVKRNELAALARGALVGMAQLRELYLTSNRLRS 537
++H+ L +K N L + +L G+A+L EL LTSN+L
Sbjct: 427 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 486
Query: 538 RALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLE---YLYLQNNKISAVPANAFDSTP 594
L R + L L+ L ++ N+L E+P L+ +L + +N++ A+P +
Sbjct: 487 --LPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544
Query: 595 NLKGIFLRFNKL 606
L+ + LR N L
Sbjct: 545 RLRYLSLRNNSL 556
Score = 109 bits (273), Expect = 7e-24
Identities = 116/394 (29%), Positives = 178/394 (45%), Gaps = 46/394 (11%)
Query: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD------EG 326
SS L +P +P L L N L +PP AF LSSL L LQ L G
Sbjct: 99 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 158
Query: 327 LDN----------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKN 367
L+N TF +L L LS+N LSR+ GL SL L+L N
Sbjct: 159 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 218
Query: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG-- 425
++ + + SL L+L N+L + P F GL L + L NAL + +
Sbjct: 219 SLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVF 276
Query: 426 --LPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
LP R++ L + N I + F L L+LS+NR+ + D F L LR L
Sbjct: 277 VQLP-RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG--LLEDTFPGLLGLRVL 333
Query: 484 DLSGNRLHTLPPGLPRNVHV---LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
LS N + +L P +++H L++ N + LA + G+ QL L L N+L+
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 393
Query: 541 GPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTPNL 596
G A++ L ++ +++++GN L +PE GL + L L+L+ + + + + F L
Sbjct: 394 G--AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLSGL 450
Query: 597 KGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ +FL+ N L + + + L L LD+ N
Sbjct: 451 RRLFLKDNGLV--GIEEQSLWGLAELLELDLTSN 482
Score = 97.4 bits (241), Expect = 4e-20
Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL-T 207
L L N + + P L L L+L +NR+ GL E F L L L L++N + +
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA--GLLEDTFPGLLGLRVLRLSHNAIAS 342
Query: 208 LAPRFLPNA--LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L PR + L + N + ++ +F L + L +N+L + + F G +
Sbjct: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLT 400
Query: 266 NVEVLILSSNFLRHVPKHLPPALYKLH---LKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
NV V+ LS N LR++P+ + L KLH L+ + L +I P F+ LS LR L+L++N L
Sbjct: 401 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 460
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTP 379
G++ ++ W L+ L LDL+SN L+ +P L + L L L +N + + A+ L P
Sbjct: 461 V--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 518
Query: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV---PSGLPR 428
++ +L + N+L + + L RL + L NN+L P GL R
Sbjct: 519 LQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 139 bits (349), Expect = 1e-32
Identities = 165/552 (29%), Positives = 233/552 (42%), Gaps = 105/552 (19%)
Query: 102 LSPEEPG-PGPA-AVSCPRDCACSQEGVVD-----CGGIDLREFPGDLPEHTNHLSLQNN 154
L +PG PG A +CP C CS + D C +L P +P T L L N
Sbjct: 25 LEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 84
Query: 155 QLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLP 214
L + P L L LNLQ +L S L +A L NL +L+L N+L R L
Sbjct: 85 NLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENLCHLHLERNQL----RSLA 138
Query: 215 NALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSS 274
TF P L S+ L NN+L+ L D +F G +
Sbjct: 139 LG-----------------TFAHTPALASLGLSNNRLSR--LEDGLFEGLGS-------- 171
Query: 275 NFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWK 334
L+ L+L N L +P AF L SLREL L N L L F
Sbjct: 172 -------------LWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSG 216
Query: 335 LSSLEYLDLSSNNLSRVPAG----LPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHS 390
L+ L LDLS N L + A LPR L L+L++N I +V +++L +L L
Sbjct: 217 LAELRELDLSRNALRAIKANVFVQLPR-LQKLYLDRNLIAAVAPGAFLGLKALRWLDLSH 275
Query: 391 NQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL------HNQITGIG 444
N R G+ F GL L + L +NA + S PR + L L HN+I +
Sbjct: 276 N--RVAGLLEDTFPGLLGLRVLRLSHNA---IASLRPRTFKDLHFLEELQLGHNRIRQLA 330
Query: 445 REDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP------GLP 498
F LE L L +N++ +V AF L + ++LSGN L LP G
Sbjct: 331 ERSFEGLGQLEVLTLDHNQLQ--EVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
Query: 499 RNVHV---------------------LKVKRNELAALARGALVGMAQLRELYLTSNRLRS 537
++H+ L +K N L + +L G+A+L EL LTSN+L
Sbjct: 389 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 448
Query: 538 RALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLE---YLYLQNNKISAVPANAFDSTP 594
L R + L L+ L ++ N+L E+P L+ +L + +N++ A+P +
Sbjct: 449 --LPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 506
Query: 595 NLKGIFLRFNKL 606
L+ + LR N L
Sbjct: 507 RLRYLSLRNNSL 518
Score = 109 bits (273), Expect = 7e-24
Identities = 116/394 (29%), Positives = 178/394 (45%), Gaps = 46/394 (11%)
Query: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD------EG 326
SS L +P +P L L N L +PP AF LSSL L LQ L G
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
Query: 327 LDN----------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKN 367
L+N TF +L L LS+N LSR+ GL SL L+L N
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
Query: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG-- 425
++ + + SL L+L N+L + P F GL L + L NAL + +
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVF 238
Query: 426 --LPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
LP R++ L + N I + F L L+LS+NR+ + D F L LR L
Sbjct: 239 VQLP-RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG--LLEDTFPGLLGLRVL 295
Query: 484 DLSGNRLHTLPPGLPRNVHV---LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
LS N + +L P +++H L++ N + LA + G+ QL L L N+L+
Sbjct: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
Query: 541 GPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTPNL 596
G A++ L ++ +++++GN L +PE GL + L L+L+ + + + + F L
Sbjct: 356 G--AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLSGL 412
Query: 597 KGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ +FL+ N L + + + L L LD+ N
Sbjct: 413 RRLFLKDNGLV--GIEEQSLWGLAELLELDLTSN 444
Score = 97.4 bits (241), Expect = 4e-20
Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL-T 207
L L N + + P L L L+L +NR+ GL E F L L L L++N + +
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA--GLLEDTFPGLLGLRVLRLSHNAIAS 304
Query: 208 LAPRFLPNA--LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L PR + L + N + ++ +F L + L +N+L + + F G +
Sbjct: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLT 362
Query: 266 NVEVLILSSNFLRHVPKHLPPALYKLH---LKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
NV V+ LS N LR++P+ + L KLH L+ + L +I P F+ LS LR L+L++N L
Sbjct: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTP 379
G++ ++ W L+ L LDL+SN L+ +P L + L L L +N + + A+ L P
Sbjct: 423 V--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
Query: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV---PSGLPR 428
++ +L + N+L + + L RL + L NN+L P GL R
Sbjct: 481 LQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 134 bits (338), Expect = 2e-31
Identities = 144/487 (29%), Positives = 207/487 (42%), Gaps = 76/487 (15%)
Query: 108 GP-GPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSR 166
GP G A C C+C + VDC G L P L T L + N + ++ +
Sbjct: 20 GPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKN 79
Query: 167 LHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAP----RFLPNALISVDF 222
LE L L N L+ + KA L L L L NN+L P R L +AL S+
Sbjct: 80 FPFLEELQLAGNDLSF--IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGL-SALQSLRL 136
Query: 223 AANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPK 282
AN++T + P++ F G + L L N L VP
Sbjct: 137 DANHITSV--------------------------PEDSFEGLVQLRHLWLDDNSLTEVPV 170
Query: 283 HLP---PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLE 339
H P L L L NK+ IP AF+ LSSL L+L NN + L F L +LE
Sbjct: 171 HPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKI--RSLSQHCFDGLDNLE 228
Query: 340 YLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIH 399
LDL+ NNL P + + SL+ L HSN + I
Sbjct: 229 TLDLNYNNLGEFP----------------------QAIKALPSLKELGFHSNSISV--IP 264
Query: 400 PLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGRE--DFATTYFLEEL 457
AF G L T+HLY+N L V + + L L + + ++ + T LE L
Sbjct: 265 DGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESL 324
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK---VKRNELAAL 514
L+ +I+S + + ++ ++LR+LDLS N + LP H L+ ++RN++ +
Sbjct: 325 TLTGTKISS--IPNNLCQEQKMLRTLDLSYNNIRDLPSF--NGCHALEEISLQRNQIYQI 380
Query: 515 ARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP-EGLPESLE 573
G G+ LR L L+ N + + RA+ L + LD++ N+LT P EGL L
Sbjct: 381 KEGTFQGLISLRILDLSRNLIHE--IHSRAFATLGPITNLDVSFNELTSFPTEGL-NGLN 437
Query: 574 YLYLQNN 580
L L N
Sbjct: 438 QLKLVGN 444
Score = 87.4 bits (215), Expect = 4e-17
Identities = 101/388 (26%), Positives = 157/388 (40%), Gaps = 60/388 (15%)
Query: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETF 332
S L VP+ L L + N + ++P AF L EL L N L+ + +
Sbjct: 44 SGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF--IHPKAL 101
Query: 333 WKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTPIRSLEYLLLH 389
L L+ L L +N L VP+ R L L L+ N I SV + + L +L L
Sbjct: 102 SGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLD 161
Query: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH---NQITGIGRE 446
N L E +HPL+ L L + L N + +P + +L++LH N+I + +
Sbjct: 162 DNSLTEVPVHPLS--NLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
Query: 447 DFATTYFLEELNLSYNRITS-PQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
F LE L+L+YN + PQ A + L L+ L N + +P G
Sbjct: 220 CFDGLDNLETLDLNYNNLGEFPQ----AIKALPSLKELGFHSNSISVIPDG--------- 266
Query: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565
A G LR ++L N L +G A+ +L+ L L I G + +
Sbjct: 267 ------------AFDGNPLLRTIHLYDNPLSF--VGNSAFHNLSDLHSLVIRGASMVQQF 312
Query: 566 EGLPES--LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL----------------- 606
L + LE L L KIS++P N L+ + L +N +
Sbjct: 313 PNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHALEEISL 372
Query: 607 ---AVGSVVDSAFRRLKHLQVLDIEGNL 631
+ + + F+ L L++LD+ NL
Sbjct: 373 QRNQIYQIKEGTFQGLISLRILDLSRNL 400
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 2/77 (2%)
Query: 554 LDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVD 613
+D +G LT +PEGL + L + N I+ +P +AF + P L+ + L N L+ +
Sbjct: 41 VDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF--IHP 98
Query: 614 SAFRRLKHLQVLDIEGN 630
A LK L+VL ++ N
Sbjct: 99 KALSGLKELKVLTLQNN 115
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 131 bits (330), Expect = 2e-30
Identities = 77/223 (34%), Positives = 122/223 (54%), Gaps = 2/223 (0%)
Query: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445
L L +NQ+ GI P + L ++ ++LY+N+L+ P+ LP+ V+ L + N I I
Sbjct: 63 LYLQNNQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 446 EDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
+ + +LEEL+L N +++ + AFR LR L LS N L T+P GLPR + L+
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565
+ N ++ ++ +L G+ L+ L L N L + LG + + +L +L L + N LT P
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Query: 566 EGLP-ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA 607
LP +L LYLQ+N I+ VP NAF L + + N L+
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Score = 111 bits (278), Expect = 2e-24
Identities = 87/308 (28%), Positives = 138/308 (44%), Gaps = 33/308 (10%)
Query: 113 AVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLET 172
A SCP C C G + C L P +PE T
Sbjct: 28 AKSCPSVCRCDA-GFIYCNDRFLTSIPTGIPEDAT------------------------T 62
Query: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232
L LQNN++ + G+P ++L + +YL +N L P LP + + N + I
Sbjct: 63 LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292
+ + P L ++L +N ++ + + F S+ + +L LS N L +P LP + +L
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
L +N++ I + L+SL+ L L N L + GL ++ F+ L +L L L N+L+ P
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Query: 353 AGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE--QGIHPLAFQGLKRL 409
LP +L L+L+ N I V N + +R L L + +N L QGI F L +
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGI----FDDLDNI 297
Query: 410 HTVHLYNN 417
+ L NN
Sbjct: 298 TQLILRNN 305
Score = 110 bits (274), Expect = 5e-24
Identities = 79/256 (30%), Positives = 123/256 (48%), Gaps = 28/256 (10%)
Query: 243 SVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIP 302
++YL NN++ +AG+P ++ N VE + L N L P +LP + +LHL+ N + I
Sbjct: 62 TLYLQNNQINNAGIPSDLKN-LLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
Query: 303 PGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL 362
+ S++ L EL+L +N ++ ++ F + L L LS N+LS +P GLPR++ L
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
Query: 363 HLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV 422
L+ N I ++ + L + SL+ L+L N L G+ F L L + L N+L
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
Query: 423 PSGLP-RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLR 481
P LP +R L + N I +V +AF LR L
Sbjct: 241 PVNLPGTNLRKLYLQDNHIN--------------------------RVPPNAFSYLRQLY 274
Query: 482 SLDLSGNRLHTLPPGL 497
LD+S N L LP G+
Sbjct: 275 RLDMSNNNLSNLPQGI 290
Score = 97.8 bits (242), Expect = 3e-20
Identities = 83/293 (28%), Positives = 130/293 (44%), Gaps = 32/293 (10%)
Query: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
++ + L IP G + ++L YLQNN + + G+ ++ L +E + L N+L
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
Query: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
P LP+ + LHL++N IR++ + L+ I LE L L N + I AF+ L
Sbjct: 98 FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
+ L N L +P GLPR + L + N+I+ I L+ L L N + + +
Sbjct: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
F L L L L N L P LP LR+LYL
Sbjct: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPG-----------------------TNLRKLYL 254
Query: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLE---YLYLQNN 580
N + + P A+ L L LD++ N L+ +P+G+ + L+ L L+NN
Sbjct: 255 QDNHI--NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Score = 73.9 bits (180), Expect = 4e-13
Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 25/219 (11%)
Query: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471
++ + L +P+G+P TL + +NQI G +
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG------------------------IPS 77
Query: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531
D L++ R + L N L P LP+ V L ++ N + + +L + L EL+L
Sbjct: 78 DLKNLLKVER-IYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLD 136
Query: 532 SNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFD 591
N + + ++ A+ D +L+LL ++ N L+ IP GLP ++E L L +N+IS + + +
Sbjct: 137 DNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQ 196
Query: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+LK + L N L + D F L +L L + N
Sbjct: 197 GLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRN 235
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 131 bits (330), Expect = 2e-30
Identities = 77/223 (34%), Positives = 122/223 (54%), Gaps = 2/223 (0%)
Query: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445
L L +NQ+ GI P + L ++ ++LY+N+L+ P+ LP+ V+ L + N I I
Sbjct: 63 LYLQNNQINNAGI-PSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 446 EDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
+ + +LEEL+L N +++ + AFR LR L LS N L T+P GLPR + L+
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565
+ N ++ ++ +L G+ L+ L L N L + LG + + +L +L L + N LT P
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Query: 566 EGLP-ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLA 607
LP +L LYLQ+N I+ VP NAF L + + N L+
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Score = 111 bits (278), Expect = 2e-24
Identities = 87/308 (28%), Positives = 138/308 (44%), Gaps = 33/308 (10%)
Query: 113 AVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLET 172
A SCP C C G + C L P +PE T
Sbjct: 28 AKSCPSVCRCDA-GFIYCNDRFLTSIPTGIPEDAT------------------------T 62
Query: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232
L LQNN++ + G+P ++L + +YL +N L P LP + + N + I
Sbjct: 63 LYLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITY 121
Query: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292
+ + P L ++L +N ++ + + F S+ + +L LS N L +P LP + +L
Sbjct: 122 DSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELR 181
Query: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
L +N++ I + L+SL+ L L N L + GL ++ F+ L +L L L N+L+ P
Sbjct: 182 LDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Query: 353 AGLP-RSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE--QGIHPLAFQGLKRL 409
LP +L L+L+ N I V N + +R L L + +N L QGI F L +
Sbjct: 242 VNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGI----FDDLDNI 297
Query: 410 HTVHLYNN 417
+ L NN
Sbjct: 298 TQLILRNN 305
Score = 110 bits (274), Expect = 5e-24
Identities = 79/256 (30%), Positives = 123/256 (48%), Gaps = 28/256 (10%)
Query: 243 SVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIP 302
++YL NN++ +AG+P ++ N VE + L N L P +LP + +LHL+ N + I
Sbjct: 62 TLYLQNNQINNAGIPSDLKN-LLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTIT 120
Query: 303 PGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL 362
+ S++ L EL+L +N ++ ++ F + L L LS N+LS +P GLPR++ L
Sbjct: 121 YDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEEL 180
Query: 363 HLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV 422
L+ N I ++ + L + SL+ L+L N L G+ F L L + L N+L
Sbjct: 181 RLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAA 240
Query: 423 PSGLP-RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLR 481
P LP +R L + N I +V +AF LR L
Sbjct: 241 PVNLPGTNLRKLYLQDNHIN--------------------------RVPPNAFSYLRQLY 274
Query: 482 SLDLSGNRLHTLPPGL 497
LD+S N L LP G+
Sbjct: 275 RLDMSNNNLSNLPQGI 290
Score = 97.8 bits (242), Expect = 3e-20
Identities = 83/293 (28%), Positives = 130/293 (44%), Gaps = 32/293 (10%)
Query: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSR 350
++ + L IP G + ++L YLQNN + + G+ ++ L +E + L N+L
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTL---YLQNNQINNAGIPSD-LKNLLKVERIYLYHNSLDE 97
Query: 351 VPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLH 410
P LP+ + LHL++N IR++ + L+ I LE L L N + I AF+ L
Sbjct: 98 FPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLR 157
Query: 411 TVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVH 470
+ L N L +P GLPR + L + N+I+ I L+ L L N + + +
Sbjct: 158 LLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLG 217
Query: 471 RDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYL 530
F L L L L N L P LP LR+LYL
Sbjct: 218 DKVFFNLVNLTELSLVRNSLTAAPVNLPG-----------------------TNLRKLYL 254
Query: 531 TSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLE---YLYLQNN 580
N + + P A+ L L LD++ N L+ +P+G+ + L+ L L+NN
Sbjct: 255 QDNHI--NRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Score = 73.9 bits (180), Expect = 4e-13
Identities = 57/219 (26%), Positives = 99/219 (45%), Gaps = 25/219 (11%)
Query: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471
++ + L +P+G+P TL + +NQI G +
Sbjct: 42 IYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG------------------------IPS 77
Query: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531
D L++ R + L N L P LP+ V L ++ N + + +L + L EL+L
Sbjct: 78 DLKNLLKVER-IYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLD 136
Query: 532 SNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFD 591
N + + ++ A+ D +L+LL ++ N L+ IP GLP ++E L L +N+IS + + +
Sbjct: 137 DNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQ 196
Query: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+LK + L N L + D F L +L L + N
Sbjct: 197 GLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRN 235
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 130 bits (328), Expect = 3e-30
Identities = 123/410 (30%), Positives = 189/410 (46%), Gaps = 28/410 (6%)
Query: 99 VLVLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEK 158
+L L P GP A C C C+ + + DCGG L PGDLP T L+L N+L +
Sbjct: 25 LLRLEPVTAAAGPRA-PCAAACTCAGDSL-DCGGRGLAALPGDLPSWTRSLNLSYNKLSE 82
Query: 159 IYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALI 218
I P L L+ + L NN LT+ A H+ + L+L +NK+ A +
Sbjct: 83 IDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVS---LFLQHNKIRSVEGSQLKAYL 139
Query: 219 S---VDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNG-SSNVEVLILSS 274
S +D + N +T++ F P ++ + L N++ L F+G S ++ L LS
Sbjct: 140 SLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL--GAFDGLSRSLLTLRLSK 197
Query: 275 NFLRHVPKHL--PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETF 332
N + +P P L +L L N++ I F L+SL L LQ N ++ L + F
Sbjct: 198 NRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISK--LTDGAF 255
Query: 333 WKLSSLEYLDLSSNNLSRVPAGLPRSLVL---LHLEKNAIRSVDANVLTPIRSLEYLLLH 389
W LS + L L N+L V +G L LHL N+I + + + L L+L
Sbjct: 256 WGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLS 315
Query: 390 SNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGRE 446
N L LA L L + L +N++ + G + +R+L +L HN+I+G +
Sbjct: 316 FNNLTRLDEESLA--ELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIED 373
Query: 447 D---FATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTL 493
F+ L +L L N+I S V + AF L L L+L GN + ++
Sbjct: 374 TSGAFSGLDSLSKLTLFGNKIKS--VAKRAFSGLEGLEHLNLGGNAIRSV 421
Score = 110 bits (275), Expect = 4e-24
Identities = 125/412 (30%), Positives = 189/412 (45%), Gaps = 49/412 (11%)
Query: 206 LTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
L P LP+ S++ + N L++I F PNL+ VYL+NN+L ++ SS
Sbjct: 59 LAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV---PSLGAASS 115
Query: 266 NVEVLILSSNFLRHVPKHLPPA---LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
+V L L N +R V A L L L N + ++ F ++EL L N +
Sbjct: 116 HVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRI 175
Query: 323 TDEGLDNETFWKLS-SLEYLDLSSNNLSRVPAG---LPRSLVLLHLEKNAIRSVDANVLT 378
L+ F LS SL L LS N ++++P LPR L L L +N IR ++
Sbjct: 176 GT--LELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPR-LTQLDLNRNRIRLIEGLTFQ 232
Query: 379 PIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH- 437
+ SLE L L N + + + AF GL ++H +HL N+L V SG + L LH
Sbjct: 233 GLNSLEVLKLQRNNISK--LTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHL 290
Query: 438 --NQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP 495
N I I R+ ++ L EL LS+N +T ++ ++ +L L L LS N + +
Sbjct: 291 SNNSIARIHRKGWSFCQKLHELVLSFNNLT--RLDEESLAELSSLSVLRLSHNSISHIAE 348
Query: 496 GL---PRNVHVLKVKRNELAALAR---GALVGMAQLRELYLTSNRLRSRALGPRAWVDLA 549
G R++ VL + NE++ GA G+ L +L L N+++S A RA+ L
Sbjct: 349 GAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVA--KRAFSGL- 405
Query: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFL 601
E LE+L L N I +V +AF NLK + +
Sbjct: 406 --------------------EGLEHLNLGGNAIRSVQFDAFVKMKNLKELHI 437
Score = 73.6 bits (179), Expect = 6e-13
Identities = 81/312 (25%), Positives = 126/312 (40%), Gaps = 64/312 (20%)
Query: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPS--GLPRRVRTLMILHNQITGI 443
L L N+L E I P F+ L L V+L NN L VPS V +L + HN+I +
Sbjct: 73 LNLSYNKLSE--IDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSV 130
Query: 444 GREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPG------- 496
LE L+LS N IT +V F ++ L+L+GNR+ TL G
Sbjct: 131 EGSQLKAYLSLEVLDLSLNNIT--EVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
Query: 497 ---------------------LPR-----------------------NVHVLKVKRNELA 512
LPR ++ VLK++RN ++
Sbjct: 189 SLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNIS 248
Query: 513 ALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPE---GLP 569
L GA G++++ L+L N L G + L L L ++ N + I
Sbjct: 249 KLTDGAFWGLSKMHVLHLEYNSLVEVNSG--SLYGLTALHQLHLSNNSIARIHRKGWSFC 306
Query: 570 ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEG 629
+ L L L N ++ + + +L LR + ++ + + AF+ L+ L+VLD++
Sbjct: 307 QKLHELVLSFNNLTRLDEESLAELSSLS--VLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
Query: 630 NLEFGDISKDRG 641
N G I G
Sbjct: 365 NEISGTIEDTSG 376
Score = 50.4 bits (119), Expect = 5e-06
Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 15/208 (7%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
L LQ N + K+ L ++ L+L+ N L + + LT L+ L+L+NN +
Sbjct: 240 LKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVE--VNSGSLYGLTALHQLHLSNNSIAR 297
Query: 209 APR---FLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
R L + + N LT++ + + +L + L +N ++ + + F G
Sbjct: 298 IHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISH--IAEGAFKGLR 355
Query: 266 NVEVLILSSNFLRHVPKHLPPA------LYKLHLKNNKLEKIPPGAFSELSSLRELYLQN 319
++ VL L N + + A L KL L NK++ + AFS L L L L
Sbjct: 356 SLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGG 415
Query: 320 NYLTDEGLDNETFWKLSSLEYLDLSSNN 347
N + D F K+ +L+ L +SS++
Sbjct: 416 NAIRSVQFD--AFVKMKNLKELHISSDS 441
Score = 43.5 bits (101), Expect = 6e-04
Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 30/175 (17%)
Query: 482 SLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRL------ 535
SLD G L LP LP L + N+L+ + + L+E+YL +N L
Sbjct: 51 SLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSL 110
Query: 536 ---------------RSRALGPRAWVDLAHLQLLDIAGNQLTEI-----PEGLPESLEYL 575
+ R++ L++LD++ N +TE+ P G P ++ L
Sbjct: 111 GAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPP--IKEL 168
Query: 576 YLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L N+I + AFD + + LR +K + + AF +L L LD+ N
Sbjct: 169 NLAGNRIGTLELGAFDGL-SRSLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRN 221
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/102 (33%), Positives = 47/102 (46%), Gaps = 12/102 (11%)
Query: 539 ALGPRAWVDLAHL---QLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPN 595
A GPRA A LD G L +P LP L L NK+S + F+ PN
Sbjct: 34 AAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPN 93
Query: 596 LKGIFLRFNKL-------AVGSVVDSAFRRLKHLQVLDIEGN 630
L+ ++L N+L A S V S F L+H ++ +EG+
Sbjct: 94 LQEVYLNNNELTAVPSLGAASSHVVSLF--LQHNKIRSVEGS 133
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 128 bits (322), Expect = 1e-29
Identities = 95/328 (28%), Positives = 153/328 (46%), Gaps = 23/328 (7%)
Query: 92 EFAEEEPVLVLSPE-------EPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPE 144
+F E+ + PE EP GP CP C C VV C + L + P DLP
Sbjct: 26 DFMLEDEASGIGPEVPDDRDFEPSLGPV---CPFRCQCHLR-VVQCSDLGLDKVPKDLPP 81
Query: 145 HTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN 204
T L LQNN++ +I + L L L L NN+++ + AF L L LYL+ N
Sbjct: 82 DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLVKLERLYLSKN 139
Query: 205 KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGS 264
+L P +P L + N +TK+ +TF + + L N L +G+ + F G
Sbjct: 140 QLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGM 199
Query: 265 SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324
+ + ++ + +P+ LPP+L +LHL NK+ ++ + L++L +L L N ++
Sbjct: 200 KKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS- 258
Query: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLP--RSLVLLHLEKNAIRSVDANVLTP--- 379
+DN + L L L +N L+RVP GL + + +++L N I V ++ P
Sbjct: 259 -AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGH 317
Query: 380 ---IRSLEYLLLHSNQLREQGIHPLAFQ 404
S + L SN ++ I P F+
Sbjct: 318 NTKKASYSGVSLFSNPVQYWEIQPSTFR 345
Score = 112 bits (279), Expect = 1e-24
Identities = 79/265 (29%), Positives = 126/265 (47%), Gaps = 6/265 (2%)
Query: 186 PEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVY 245
P F +L + ++ L P+ LP +D N +T+I F NL ++
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
Query: 246 LHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGA 305
L NNK++ F +E L LS N L+ +P+ +P L +L N++ K+
Sbjct: 112 LVNNKISKVS--PGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 306 FSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLE 365
F+ L+ + + L N L G++N F + L Y+ ++ N++ +P GLP SL LHL+
Sbjct: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
Query: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425
N I VDA L + +L L L N + LA L +HL NN L RVP G
Sbjct: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGG 287
Query: 426 LP--RRVRTLMILHNQITGIGREDF 448
L + ++ + + +N I+ +G DF
Sbjct: 288 LAEHKYIQVVYLHNNNISVVGSSDF 312
Score = 105 bits (262), Expect = 1e-22
Identities = 74/243 (30%), Positives = 116/243 (47%), Gaps = 4/243 (1%)
Query: 261 FNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN 320
F ++ V+ S L VPK LPP L L+NNK+ +I G F L +L L L NN
Sbjct: 56 FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
Query: 321 YLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI 380
++ + F L LE L LS N L +P +P++L L +N I V +
Sbjct: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
Query: 381 RSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQI 440
+ + L +N L+ GI AFQG+K+L + + + + +P GLP + L + N+I
Sbjct: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
Query: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500
+ + L +L LS+N I++ V + LR L L N+L +P GL +
Sbjct: 234 SRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
Query: 501 VHV 503
++
Sbjct: 292 KYI 294
Score = 104 bits (259), Expect = 3e-22
Identities = 75/288 (26%), Positives = 140/288 (48%), Gaps = 12/288 (4%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
L + S L +VP LP LL L+ N I + +++L L+L +N++ +
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK-- 119
Query: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
+ P AF L +L ++L N L+ +P +P+ ++ L N+IT + + F + +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
L N + S + AF+ ++ L + ++ + ++P GLP ++ L + N+++ +
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES--LEYL 575
+L G+ L +L L+ N + + G A + HL+ L + N+LT +P GL E ++ +
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
Query: 576 YLQNNKISAVPANAF------DSTPNLKGIFLRFNKLAVGSVVDSAFR 617
YL NN IS V ++ F + G+ L N + + S FR
Sbjct: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFR 345
Score = 99.8 bits (247), Expect = 7e-21
Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 4/222 (1%)
Query: 409 LHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ 468
L V + L++VP LP L + +N+IT I DF L L L N+I+ +
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--K 119
Query: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528
V AF L L L LS N+L LP +P+ + L+ NE+ + + G+ Q+ +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 529 YLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPAN 588
L +N L+S + A+ + L + IA +T IP+GLP SL L+L NKIS V A
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 589 AFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ NL + L FN ++ +V + + HL+ L ++ N
Sbjct: 240 SLKGLNNLAKLGLSFN--SISAVDNGSLANTPHLRELHLDNN 279
Score = 40.0 bits (92), Expect = 0.007
Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609
HL+++ + L ++P+ LP L LQNNKI+ + F + NL + L NK +
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNK--IS 118
Query: 610 SVVDSAFRRLKHLQVLDIEGN 630
V AF L L+ L + N
Sbjct: 119 KVSPGAFTPLVKLERLYLSKN 139
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 128 bits (322), Expect = 1e-29
Identities = 95/328 (28%), Positives = 153/328 (46%), Gaps = 23/328 (7%)
Query: 92 EFAEEEPVLVLSPE-------EPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPE 144
+F E+ + PE EP GP CP C C VV C + L + P DLP
Sbjct: 26 DFMLEDEASGIGPEVPDDRDFEPSLGPV---CPFRCQCHLR-VVQCSDLGLDKVPKDLPP 81
Query: 145 HTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN 204
T L LQNN++ +I + L L L L NN+++ + AF L L LYL+ N
Sbjct: 82 DTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK--VSPGAFTPLVKLERLYLSKN 139
Query: 205 KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGS 264
+L P +P L + N +TK+ +TF + + L N L +G+ + F G
Sbjct: 140 QLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGM 199
Query: 265 SNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324
+ + ++ + +P+ LPP+L +LHL NK+ ++ + L++L +L L N ++
Sbjct: 200 KKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSIS- 258
Query: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLP--RSLVLLHLEKNAIRSVDANVLTP--- 379
+DN + L L L +N L+RVP GL + + +++L N I V ++ P
Sbjct: 259 -AVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGH 317
Query: 380 ---IRSLEYLLLHSNQLREQGIHPLAFQ 404
S + L SN ++ I P F+
Sbjct: 318 NTKKASYSGVSLFSNPVQYWEIQPSTFR 345
Score = 112 bits (279), Expect = 1e-24
Identities = 79/265 (29%), Positives = 126/265 (47%), Gaps = 6/265 (2%)
Query: 186 PEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVY 245
P F +L + ++ L P+ LP +D N +T+I F NL ++
Sbjct: 52 PVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALI 111
Query: 246 LHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGA 305
L NNK++ F +E L LS N L+ +P+ +P L +L N++ K+
Sbjct: 112 LVNNKISKVS--PGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVT 169
Query: 306 FSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLE 365
F+ L+ + + L N L G++N F + L Y+ ++ N++ +P GLP SL LHL+
Sbjct: 170 FNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLD 229
Query: 366 KNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG 425
N I VDA L + +L L L N + LA L +HL NN L RVP G
Sbjct: 230 GNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGG 287
Query: 426 LP--RRVRTLMILHNQITGIGREDF 448
L + ++ + + +N I+ +G DF
Sbjct: 288 LAEHKYIQVVYLHNNNISVVGSSDF 312
Score = 105 bits (262), Expect = 1e-22
Identities = 74/243 (30%), Positives = 116/243 (47%), Gaps = 4/243 (1%)
Query: 261 FNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN 320
F ++ V+ S L VPK LPP L L+NNK+ +I G F L +L L L NN
Sbjct: 56 FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
Query: 321 YLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI 380
++ + F L LE L LS N L +P +P++L L +N I V +
Sbjct: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGL 173
Query: 381 RSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQI 440
+ + L +N L+ GI AFQG+K+L + + + + +P GLP + L + N+I
Sbjct: 174 NQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKI 233
Query: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRN 500
+ + L +L LS+N I++ V + LR L L N+L +P GL +
Sbjct: 234 SRVDAASLKGLNNLAKLGLSFNSISA--VDNGSLANTPHLRELHLDNNKLTRVPGGLAEH 291
Query: 501 VHV 503
++
Sbjct: 292 KYI 294
Score = 104 bits (259), Expect = 3e-22
Identities = 75/288 (26%), Positives = 140/288 (48%), Gaps = 12/288 (4%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
L + S L +VP LP LL L+ N I + +++L L+L +N++ +
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISK-- 119
Query: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
+ P AF L +L ++L N L+ +P +P+ ++ L N+IT + + F + +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
L N + S + AF+ ++ L + ++ + ++P GLP ++ L + N+++ +
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES--LEYL 575
+L G+ L +L L+ N + + G A + HL+ L + N+LT +P GL E ++ +
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNGSLA--NTPHLRELHLDNNKLTRVPGGLAEHKYIQVV 297
Query: 576 YLQNNKISAVPANAF------DSTPNLKGIFLRFNKLAVGSVVDSAFR 617
YL NN IS V ++ F + G+ L N + + S FR
Sbjct: 298 YLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFR 345
Score = 99.8 bits (247), Expect = 7e-21
Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 4/222 (1%)
Query: 409 LHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ 468
L V + L++VP LP L + +N+IT I DF L L L N+I+ +
Sbjct: 62 LRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKIS--K 119
Query: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528
V AF L L L LS N+L LP +P+ + L+ NE+ + + G+ Q+ +
Sbjct: 120 VSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVI 179
Query: 529 YLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPAN 588
L +N L+S + A+ + L + IA +T IP+GLP SL L+L NKIS V A
Sbjct: 180 ELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 589 AFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ NL + L FN ++ +V + + HL+ L ++ N
Sbjct: 240 SLKGLNNLAKLGLSFN--SISAVDNGSLANTPHLRELHLDNN 279
Score = 40.0 bits (92), Expect = 0.007
Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609
HL+++ + L ++P+ LP L LQNNKI+ + F + NL + L NK +
Sbjct: 61 HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNK--IS 118
Query: 610 SVVDSAFRRLKHLQVLDIEGN 630
V AF L L+ L + N
Sbjct: 119 KVSPGAFTPLVKLERLYLSKN 139
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 126 bits (317), Expect = 6e-29
Identities = 89/295 (30%), Positives = 140/295 (47%), Gaps = 28/295 (9%)
Query: 344 SSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403
+ +L+ VP G+P + +L+L H+NQ+ G P
Sbjct: 50 NERSLTSVPLGIPEGVTVLYL------------------------HNNQINNAGF-PAEL 84
Query: 404 QGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNR 463
++ +HTV+LY N L+ P LP+ VR L + N I I R A LEEL+L N
Sbjct: 85 HNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNS 144
Query: 464 ITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMA 523
I++ V AFR+ L+ L LS N L ++P GLP ++ L+V N +A ++ A +
Sbjct: 145 ISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLT 204
Query: 524 QLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES-LEYLYLQNNKI 582
L L + N L ++ + + L L+ I N L+ P LP + L LYLQ+N+I
Sbjct: 205 SLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQI 264
Query: 583 SAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDIS 637
+ +P AF + L+ + + N+L + + F L +L+ L N F D S
Sbjct: 265 NHIPLTAFSNLRKLERLDISNNQLRM--LTQGVFDNLSNLKQLTARNNPWFCDCS 317
Score = 116 bits (291), Expect = 6e-26
Identities = 80/246 (32%), Positives = 124/246 (50%), Gaps = 4/246 (1%)
Query: 244 VYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPP 303
+YLHNN++ +AG P + N S V + L N L P +LP + LHL+ N ++ I
Sbjct: 68 LYLHNNQINNAGFPAELHNVQS-VHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
Query: 304 GAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH 363
A ++L L EL+L +N ++ G+++ F + SL+ L LS N+LS VP GLP L L
Sbjct: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Query: 364 LEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP 423
+++N I + + SLE L++ N L +GI F L +L + N+L P
Sbjct: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Query: 424 SGLP-RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRS 482
LP + L + NQI I F+ LE L++S N++ + + F L L+
Sbjct: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLR--MLTQGVFDNLSNLKQ 304
Query: 483 LDLSGN 488
L N
Sbjct: 305 LTARNN 310
Score = 114 bits (285), Expect = 3e-25
Identities = 88/308 (28%), Positives = 136/308 (44%), Gaps = 35/308 (11%)
Query: 114 VSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI-YPEELSRLHRLET 172
++CP C C + V C L P +PE L L NNQ+ +P EL + + T
Sbjct: 34 LACPSVCRCDRNFVY-CNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHT 92
Query: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232
+ YL N+L P LP + + N + I
Sbjct: 93 V--------------------------YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
Query: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292
Q L ++L +N ++ G+ D F + ++++L LS N L VP LP L +L
Sbjct: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Query: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
+ N++ I AF L+SL L + N LT++G+ TF L+ L+ + N+LS P
Sbjct: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Query: 353 AGLPRS-LVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLR--EQGIHPLAFQGLKRL 409
LP + L+ L+L+ N I + + +R LE L + +NQLR QG+ F L L
Sbjct: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGV----FDNLSNL 302
Query: 410 HTVHLYNN 417
+ NN
Sbjct: 303 KQLTARNN 310
Score = 93.6 bits (231), Expect = 5e-19
Identities = 74/261 (28%), Positives = 117/261 (44%), Gaps = 26/261 (9%)
Query: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
LYL NN + + G E + S+ + L N L P LP+++ +LHL++N I+++
Sbjct: 68 LYLHNNQINNAGFPAELH-NVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
Query: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLM 434
L + LE L L N + G+ AF+ L + L N L VP GLP ++ L
Sbjct: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Query: 435 ILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP 494
+ N+I I F LE L + N +T+ + F L L+ + N L P
Sbjct: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
Query: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
P LP H+++ LYL N++ L A+ +L L+ L
Sbjct: 247 PDLP-GTHLIR----------------------LYLQDNQINHIPL--TAFSNLRKLERL 281
Query: 555 DIAGNQLTEIPEGLPESLEYL 575
DI+ NQL + +G+ ++L L
Sbjct: 282 DISNNQLRMLTQGVFDNLSNL 302
Score = 86.7 bits (213), Expect = 6e-17
Identities = 59/219 (26%), Positives = 103/219 (47%), Gaps = 25/219 (11%)
Query: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471
V+ +L VP G+P V L + +NQI G F EL+
Sbjct: 47 VYCNERSLTSVPLGIPEGVTVLYLHNNQINNAG--------FPAELH------------- 85
Query: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531
++ + ++ L GN+L P LP+NV VL ++ N + ++R AL + +L EL+L
Sbjct: 86 ----NVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLD 141
Query: 532 SNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFD 591
N + + + A+ + L+LL ++ N L+ +P GLP L+ L + N+I+ + AF
Sbjct: 142 DNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQ 201
Query: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ +L+ + + N L + + F L L+ I N
Sbjct: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN 240
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 126 bits (316), Expect = 7e-29
Identities = 85/282 (30%), Positives = 135/282 (47%), Gaps = 27/282 (9%)
Query: 113 AVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLET 172
+ +CP C C G + C L P D+P+ T
Sbjct: 51 STTCPSVCRCDN-GFIYCNDRGLTSIPADIPDDAT------------------------T 85
Query: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232
L LQNN++ + G+P+ + N+ +YL N L P LP +L + N + I
Sbjct: 86 LYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292
+ + P L ++L +N ++ + ++ F S +++L LS N L +P LP L +L
Sbjct: 145 DSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR 204
Query: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
L +N++ IP AF L+SLR L L N L ++ + ++TF +L +L L L N+L+ P
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPP 264
Query: 353 AGLPRS-LVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQL 393
LP + L L+L+ NAI + N L +R LE L L +N L
Sbjct: 265 LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL 306
Score = 114 bits (286), Expect = 2e-25
Identities = 79/255 (30%), Positives = 127/255 (49%), Gaps = 26/255 (10%)
Query: 243 SVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIP 302
++YL NN++ +AG+P ++ NV+V+ L N L P +LP +L +LHL++N + I
Sbjct: 85 TLYLQNNQINNAGIPQDL-KTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIA 143
Query: 303 PGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLL 362
+ + + L +L+L +N ++ ++ + F L+ L LS N+LS +P+GLP +L L
Sbjct: 144 RDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEEL 203
Query: 363 HLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV 422
L+ N I ++ + + SL L+L N L Q I F L+ L + L N+L
Sbjct: 204 RLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAP 263
Query: 423 PSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRS 482
P LP + L++L L N I+ + + K+R L
Sbjct: 264 PLNLP-----------------------SAHLQKLYLQDNAIS--HIPYNTLAKMRELER 298
Query: 483 LDLSGNRLHTLPPGL 497
LDLS N L TLP GL
Sbjct: 299 LDLSNNNLTTLPRGL 313
Score = 112 bits (280), Expect = 1e-24
Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 2/222 (0%)
Query: 386 LLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGR 445
L L +NQ+ GI P + + ++LY N L+ P LPR +R L + N + I R
Sbjct: 86 LYLQNNQINNAGI-PQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 446 EDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
+ A LE+L+L N +++ + DAF + L+ L LS N L ++P GLP + L+
Sbjct: 145 DSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR 204
Query: 506 VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP 565
+ N ++ + A G+ LR L L N L ++ + + L +L L + N L P
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPP 264
Query: 566 EGLPES-LEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 606
LP + L+ LYLQ+N IS +P N L+ + L N L
Sbjct: 265 LNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNL 306
Score = 103 bits (258), Expect = 4e-22
Identities = 83/269 (30%), Positives = 123/269 (45%), Gaps = 29/269 (10%)
Query: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
LYLQNN + + G+ + K++ ++ + L N+L P LPRSL LHL+ N +R++
Sbjct: 86 LYLQNNQINNAGIPQDLKTKVN-VQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIAR 144
Query: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLM 434
+ L I LE L L N + I AF K+L + L N L +PSGLP + L
Sbjct: 145 DSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELR 204
Query: 435 ILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP 494
+ N+I+ I F L L L N + + ++ D F +L+ L L L N L P
Sbjct: 205 LDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPP 264
Query: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
LP A L++LYL N + A + L+ L
Sbjct: 265 LNLP-----------------------SAHLQKLYLQDNAISHIPYNTLA--KMRELERL 299
Query: 555 DIAGNQLTEIPEGLPE---SLEYLYLQNN 580
D++ N LT +P GL + +L L L+NN
Sbjct: 300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNN 328
Score = 91.3 bits (225), Expect = 3e-18
Identities = 59/184 (32%), Positives = 100/184 (54%), Gaps = 6/184 (3%)
Query: 447 DFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKV 506
D ATT +L+ N+I + + +D K+ + + + L N L P LPR++ L +
Sbjct: 81 DDATTLYLQN-----NQINNAGIPQDLKTKVNV-QVIYLYENDLDEFPINLPRSLRELHL 134
Query: 507 KRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPE 566
+ N + +AR +L + L +L+L N + + ++ A+ D L+LL ++ N L+ IP
Sbjct: 135 QDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPS 194
Query: 567 GLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLD 626
GLP +LE L L +N+IS +P +AF +L+ + L N LA + D F RL++L L
Sbjct: 195 GLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELS 254
Query: 627 IEGN 630
+ N
Sbjct: 255 LVRN 258
Score = 43.5 bits (101), Expect = 6e-04
Identities = 28/67 (41%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 139 PGDLPE-HTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLN 197
P +LP H L LQ+N + I L+++ LE L+L NN LT+ LP F+ L NL
Sbjct: 264 PLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTT--LPRGLFDDLGNLA 321
Query: 198 YLYLANN 204
L L NN
Sbjct: 322 QLLLRNN 328
Score = 29.6 bits (65), Expect = 9.3
Identities = 18/48 (37%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 561 LTEIPEGLPESLEYLYLQNNKI--SAVPANAFDSTPNLKGIFLRFNKL 606
LT IP +P+ LYLQNN+I + +P + + N++ I+L N L
Sbjct: 72 LTSIPADIPDDATTLYLQNNQINNAGIPQD-LKTKVNVQVIYLYENDL 118
>gi|4502403 biglycan preproprotein [Homo sapiens]
Length = 368
Score = 124 bits (311), Expect = 3e-28
Identities = 95/322 (29%), Positives = 154/322 (47%), Gaps = 35/322 (10%)
Query: 101 VLSPEEPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIY 160
VL P+ P +A+ CP C C VV C + L+ P ++ T L LQNN + ++
Sbjct: 49 VLDPDSVTPTYSAM-CPFGCHCHLR-VVQCSDLGLKSVPKEISPDTTLLDLQNNDISELR 106
Query: 161 PEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISV 220
++ L L L L NN+++ + EKAF L L LY++ N L P LP++L+ +
Sbjct: 107 KDDFKGLQHLYALVLVNNKISK--IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVEL 164
Query: 221 DFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHV 280
N + K+ F N+ + + N L ++G F+G + L +S L +
Sbjct: 165 RIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDG-LKLNYLRISEAKLTGI 223
Query: 281 PKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEY 340
PK LP L +LHL +NK++ I S L L L +N + ++N + L +L
Sbjct: 224 PKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQI--RMIENGSLSFLPTLRE 281
Query: 341 LDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIH- 399
L L +N L+RVP+GLP ++ L+ + LHSN + + G++
Sbjct: 282 LHLDNNKLARVPSGLP----------------------DLKLLQVVYLHSNNITKVGVND 319
Query: 400 --PLAFQGLKRLH--TVHLYNN 417
P+ F G+KR + + L+NN
Sbjct: 320 FCPMGF-GVKRAYYNGISLFNN 340
Score = 108 bits (270), Expect = 2e-23
Identities = 76/238 (31%), Positives = 113/238 (47%), Gaps = 5/238 (2%)
Query: 261 FNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNN 320
F ++ V+ S L+ VPK + P L L+NN + ++ F L L L L NN
Sbjct: 65 FGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNN 124
Query: 321 YLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI 380
++ + + F L L+ L +S N+L +P LP SLV L + N IR V V + +
Sbjct: 125 KISK--IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGL 182
Query: 381 RSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQI 440
R++ + + N L G P AF GLK L+ + + L +P LP + L + HN+I
Sbjct: 183 RNMNCIEMGGNPLENSGFEPGAFDGLK-LNYLRISEAKLTGIPKDLPETLNELHLDHNKI 241
Query: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLP 498
I ED L L L +N+I + + L LR L L N+L +P GLP
Sbjct: 242 QAIELEDLLRYSKLYRLGLGHNQIR--MIENGSLSFLPTLRELHLDNNKLARVPSGLP 297
Score = 105 bits (262), Expect = 1e-22
Identities = 74/236 (31%), Positives = 123/236 (52%), Gaps = 7/236 (2%)
Query: 220 VDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRH 279
+D N ++++ F +L ++ L NNK++ + + F+ ++ L +S N L
Sbjct: 95 LDLQNNDISELRKDDFKGLQHLYALVLVNNKISK--IHEKAFSPLRKLQKLYISKNHLVE 152
Query: 280 VPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLE 339
+P +LP +L +L + +N++ K+P G FS L ++ + + N L + G + F L L
Sbjct: 153 IPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGL-KLN 211
Query: 340 YLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIH 399
YL +S L+ +P LP +L LHL+ N I++++ L L L L NQ+R
Sbjct: 212 YLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENG 271
Query: 400 PLAFQGLKRLHTVHLYNNALERVPSGLP--RRVRTLMILHNQITGIGREDFATTYF 453
L+F L L +HL NN L RVPSGLP + ++ + + N IT +G DF F
Sbjct: 272 SLSF--LPTLRELHLDNNKLARVPSGLPDLKLLQVVYLHSNNITKVGVNDFCPMGF 325
Score = 83.6 bits (205), Expect = 5e-16
Identities = 70/246 (28%), Positives = 111/246 (45%), Gaps = 30/246 (12%)
Query: 409 LHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQ 468
L V + L+ VP + L + +N I+ + ++DF L L L N+I+ +
Sbjct: 71 LRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKIS--K 128
Query: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528
+H AF LR L+ L +S N L +PP LP ++ L++ N + + +G G+ + +
Sbjct: 129 IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCI 188
Query: 529 YLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPA- 587
+ N L + P A+ D L L I+ +LT IP+ LPE+L L+L +NKI A+
Sbjct: 189 EMGGNPLENSGFEPGAF-DGLKLNYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELE 247
Query: 588 -----------------------NAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQV 624
+ P L+ + L NKLA V S LK LQV
Sbjct: 248 DLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLA---RVPSGLPDLKLLQV 304
Query: 625 LDIEGN 630
+ + N
Sbjct: 305 VYLHSN 310
Score = 82.4 bits (202), Expect = 1e-15
Identities = 68/255 (26%), Positives = 122/255 (47%), Gaps = 7/255 (2%)
Query: 338 LEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQG 397
L + S L VP + LL L+ N I + + ++ L L+L +N++ +
Sbjct: 71 LRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISK-- 128
Query: 398 IHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEEL 457
IH AF L++L +++ N L +P LP + L I N+I + + F+ + +
Sbjct: 129 IHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCI 188
Query: 458 NLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARG 517
+ N + + AF L+L L +S +L +P LP ++ L + N++ A+
Sbjct: 189 EMGGNPLENSGFEPGAFDGLKL-NYLRISEAKLTGIPKDLPETLNELHLDHNKIQAIELE 247
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE--SLEYL 575
L+ ++L L L N++R G ++ L L+ L + N+L +P GLP+ L+ +
Sbjct: 248 DLLRYSKLYRLGLGHNQIRMIENGSLSF--LPTLRELHLDNNKLARVPSGLPDLKLLQVV 305
Query: 576 YLQNNKISAVPANAF 590
YL +N I+ V N F
Sbjct: 306 YLHSNNITKVGVNDF 320
Score = 35.0 bits (79), Expect = 0.22
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 2/81 (2%)
Query: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609
HL+++ + L +P+ + L LQNN IS + + F +L + L NK +
Sbjct: 70 HLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYALVLVNNK--IS 127
Query: 610 SVVDSAFRRLKHLQVLDIEGN 630
+ + AF L+ LQ L I N
Sbjct: 128 KIHEKAFSPLRKLQKLYISKN 148
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 124 bits (311), Expect = 3e-28
Identities = 95/309 (30%), Positives = 147/309 (47%), Gaps = 14/309 (4%)
Query: 116 CPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNL 175
CP C C VV C + L P ++P T L LQNN++++I + L L L L
Sbjct: 75 CPFGCQCYSR-VVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLIL 133
Query: 176 QNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTF 235
NN+LT + KAF L LYL++N+L+ P LP +L + N + KI TF
Sbjct: 134 NNNKLTK--IHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTF 191
Query: 236 GQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKN 295
L + + N L + G+ F G + + I + L VPK LPP L +LHL
Sbjct: 192 KGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAK-LTSVPKGLPPTLLELHLDY 250
Query: 296 NKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGL 355
NK+ + F L+ L L NN +TD ++N + + + + L +N L ++P+GL
Sbjct: 251 NKISTVELEDFKRYKELQRLGLGNNKITD--IENGSLANIPRVREIHLENNKLKKIPSGL 308
Query: 356 P--RSLVLLHLEKNAIRSVDANVLTPI-----RSL-EYLLLHSNQLREQGIHPLAFQGLK 407
P + L ++ L N+I V N P +SL + L +N ++ + P F+ +
Sbjct: 309 PELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVL 368
Query: 408 RLHTVHLYN 416
+V L N
Sbjct: 369 SRMSVQLGN 377
Score = 113 bits (282), Expect = 6e-25
Identities = 74/238 (31%), Positives = 120/238 (50%), Gaps = 7/238 (2%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
L VP ++P L L+NNK+++I F L+SL L L NN LT + + F
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFLTTK 150
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
L L LS N LS +P LP+SL L + +N ++ + + + +L L + +N L
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
GI P AF+G+ H + + L VP GLP + L + +N+I+ + EDF L+
Sbjct: 211 GIEPGAFEGVTVFH-IRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQR 269
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLP--RNVHVLKVKRNELA 512
L L N+IT + + + +R + L N+L +P GLP + + ++ + N +A
Sbjct: 270 LGLGNNKIT--DIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIA 325
Score = 92.0 bits (227), Expect = 2e-18
Identities = 66/221 (29%), Positives = 114/221 (51%), Gaps = 9/221 (4%)
Query: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471
VH + L VP+ +P R L + +N+I I DF L L L+ N++T ++H
Sbjct: 86 VHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLT--KIHP 143
Query: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531
AF + LR L LS N+L +P LP+++ L++ N++ + + GM L L ++
Sbjct: 144 KAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMS 203
Query: 532 SNRLRSRALGPRAW--VDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANA 589
+N L + + P A+ V + H++ IA +LT +P+GLP +L L+L NKIS V
Sbjct: 204 ANPLDNNGIEPGAFEGVTVFHIR---IAEAKLTSVPKGLPPTLLELHLDYNKISTVELED 260
Query: 590 FDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
F L+ + L NK+ + + + + ++ + +E N
Sbjct: 261 FKRYKELQRLGLGNNKIT--DIENGSLANIPRVREIHLENN 299
Score = 56.6 bits (135), Expect = 7e-08
Identities = 36/142 (25%), Positives = 67/142 (47%), Gaps = 2/142 (1%)
Query: 490 LHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLA 549
L ++P +P + +L ++ N++ + G+ L L L +N+L + P+A++
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK--IHPKAFLTTK 150
Query: 550 HLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVG 609
L+ L ++ NQL+EIP LP+SL L + NK+ + + F L + + N L
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 610 SVVDSAFRRLKHLQVLDIEGNL 631
+ AF + + E L
Sbjct: 211 GIEPGAFEGVTVFHIRIAEAKL 232
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 123 bits (308), Expect = 6e-28
Identities = 163/588 (27%), Positives = 257/588 (43%), Gaps = 82/588 (13%)
Query: 110 GPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQL------------- 156
G S C S E V DC + L + P DLP + L+L +NQL
Sbjct: 18 GMLCASSTTKCTVSHE-VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQ 76
Query: 157 -----------EKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANN- 204
K+ PE +L L+ LNLQ+N L+ L +K F TNL L+L +N
Sbjct: 77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQ--LSDKTFAFCTNLTELHLMSNS 134
Query: 205 --KLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFN 262
K+ P LI++D + N L+ T Q NL+ + L NNK+ +
Sbjct: 135 IQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIF 194
Query: 263 GSSNVEVLILSSNFLRHVPK---HLPPALYKLHLKNNKLEKIPPGAFSEL------SSLR 313
+S+++ L LSSN ++ H L+ L L N +L P +L +S+R
Sbjct: 195 ANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQL---GPSLTEKLCLELANTSIR 251
Query: 314 ELYLQNNYLTDEGLDNETF--WKLSSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKN 367
L L N+ L+ N TF K ++L LDLS NNL+ V A LP+ L LE N
Sbjct: 252 NLSLSNSQLST--TSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQ-LEYFFLEYN 308
Query: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQ-------GIHPLAFQGLKRLHTVHLYNNALE 420
I+ + ++ L + ++ YL L + ++ I +FQ LK L +++ +N +
Sbjct: 309 NIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIP 368
Query: 421 RVPSGLPRRVRTL--MILHNQITG---IGREDFATTYF--LEELNLSYNRITSPQVHRDA 473
+ S + + L + L N T + E F + L LNL+ N+I+ ++ DA
Sbjct: 369 GIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKIS--KIESDA 426
Query: 474 FRKLRLLRSLDLSGNRLHTLPPGLP----RNVHVLKVKRNELAALARGALVGMAQLRELY 529
F L L LDL N + G N+ + + N+ L R + + L+ L
Sbjct: 427 FSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLM 486
Query: 530 LTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIP----EGLPESLEYLYLQNNKISAV 585
L L++ P + L +L +LD++ N + I EGL E LE L LQ+N ++ +
Sbjct: 487 LRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGL-EKLEILDLQHNNLARL 545
Query: 586 PANAFDSTP--NLKGI----FLRFNKLAVGSVVDSAFRRLKHLQVLDI 627
+A P LKG+ L + F+ L L+++D+
Sbjct: 546 WKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDL 593
Score = 77.4 bits (189), Expect = 4e-14
Identities = 111/399 (27%), Positives = 165/399 (41%), Gaps = 78/399 (19%)
Query: 148 HLSLQNNQLEKIYPEELSRLH--RLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNK 205
+LSL N+QL L L L+L N L G +F L L Y +L N
Sbjct: 252 NLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVG--NDSFAWLPQLEYFFLEYNN 309
Query: 206 LTLAPRFLPNALISVDF------------AANYLTKIYGLTFGQKPNLRSVYLHNNKLAD 253
+ + L +V + + L KI +F L + + +N +
Sbjct: 310 IQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIP- 368
Query: 254 AGLPDNMFNGSSNVEVLILSSNF-------------LRHVPKHLPPALYKLHLKNNKLEK 300
G+ NMF G N++ L LS++F L H P H+ L+L NK+ K
Sbjct: 369 -GIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHI------LNLTKNKISK 421
Query: 301 IPPGAFSELSSLRELYLQNNYLTDE-------GLDNETFWKLSSLEYLDLSSNNLSRVPA 353
I AFS L L L L N + E GL+N LS +YL L+ N+ + VP
Sbjct: 422 IESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVP- 480
Query: 354 GLPRSLVLLHLEKNAIRSVDANV--LTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHT 411
SL L L + A+++VD++ P+R+L L L +N + I+ +GL++L
Sbjct: 481 ----SLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIAN--INDDMLEGLEKLEI 534
Query: 412 VHLYNNALERV-----PSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITS 466
+ L +N L R+ P G ++ L LH LNL N
Sbjct: 535 LDLQHNNLARLWKHANPGGPIYFLKGLSHLHI------------------LNLESNGFDE 576
Query: 467 PQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLK 505
V + F+ L L+ +DL N L+TLP + N LK
Sbjct: 577 IPV--EVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLK 613
Score = 67.0 bits (162), Expect = 5e-11
Identities = 82/263 (31%), Positives = 114/263 (43%), Gaps = 49/263 (18%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTS-------RGLPEKAFE-HLTNLNYLY 200
L+L N++ KI + S L LE L+L N + RGL E FE +L+ YL
Sbjct: 412 LNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL-ENIFEIYLSYNKYLQ 470
Query: 201 LANNKLTLAP---RFLPN--ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAG 255
L N L P R + AL +VD + + F NL + L NN +A+
Sbjct: 471 LTRNSFALVPSLQRLMLRRVALKNVDSSPS--------PFQPLRNLTILDLSNNNIAN-- 520
Query: 256 LPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLREL 315
+ D+M G +E+L L N L + KH P G L L L
Sbjct: 521 INDDMLEGLEKLEILDLQHNNLARLWKHANPG----------------GPIYFLKGLSHL 564
Query: 316 YLQNNYLTDEGLDN---ETFWKLSSLEYLDLSSNNLSRVPAGL---PRSLVLLHLEKNAI 369
++ N L G D E F L L+ +DL NNL+ +PA + SL L+L+KN I
Sbjct: 565 HILN--LESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 622
Query: 370 RSVDANVLTP-IRSLEYLLLHSN 391
SV+ V P R+L L + N
Sbjct: 623 TSVEKKVFGPAFRNLTELDMRFN 645
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 120 bits (302), Expect = 3e-27
Identities = 123/447 (27%), Positives = 206/447 (46%), Gaps = 54/447 (12%)
Query: 106 EPGPGPAAVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELS 165
+P A CP C C + ++DC L P LP L L +N+L I +S
Sbjct: 37 QPSGVAAERPCPTTCRCLGD-LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMS 95
Query: 166 RLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLT-LAPRFLP--NALISVDF 222
L L + L NN L + +P N+ L LA N++ + P L +L ++D
Sbjct: 96 HLQSLREVKLNNNELET--IPNLG-PVSANITLLSLAGNRIVEILPEHLKEFQSLETLDL 152
Query: 223 AANYLTKIYGLTFGQKPNLRSVYLHNNKLA--DAGLPDNMFNGSSNVEVLILSSNFLRHV 280
++N ++++ T L+ +YL++N++ + G DN+ N + VL L+ N + +
Sbjct: 153 SSNNISELQ--TAFPALQLKYLYLNSNRVTSMEPGYFDNLAN---TLLVLKLNRNRISAI 207
Query: 281 PKHL--PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSL 338
P + P L L L NK++ + F L +L+ L +Q N +T L + FW LS++
Sbjct: 208 PPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK--LMDGAFWGLSNM 265
Query: 339 EYLDLSSNNLSRVPAGLPRSLVL---LHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLRE 395
E L L NNL+ + G L++ LHL +NAI + + + L L L N L
Sbjct: 266 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325
Query: 396 QGIHPLAFQGLKRLHTVHLYNNALERVPSGLPR---RVRTLMILHNQITGIGREDFATTY 452
+ +F GL L+T+H+ NN + + R ++TL + +N+I ++
Sbjct: 326 --LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEI----------SW 373
Query: 453 FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP----PGLPRNVHVLKVKR 508
+E++N AF L LR L L GNR+ ++ GL H L +
Sbjct: 374 TIEDMN-------------GAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEH-LDLSD 419
Query: 509 NELAALARGALVGMAQLRELYLTSNRL 535
N + +L A M +L++L+L ++ L
Sbjct: 420 NAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 98.6 bits (244), Expect = 2e-20
Identities = 110/399 (27%), Positives = 180/399 (45%), Gaps = 68/399 (17%)
Query: 268 EVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGL 327
++L S L +P+ LP + +L L +N+L I + S L SLRE+ L NN L E +
Sbjct: 56 DLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNEL--ETI 113
Query: 328 DN-----------------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR-SLVLLH 363
N E + SLE LDLSSNN+S + P L L+
Sbjct: 114 PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLY 173
Query: 364 LEKNAIRSVD-------ANVLTPIR-----------------SLEYLLLHSNQLREQGIH 399
L N + S++ AN L ++ L++L L+ N+++ +
Sbjct: 174 LNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIK--NVD 231
Query: 400 PLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGREDFATTYFLEE 456
L FQGL L ++ + N + ++ G + + IL HN +T I + L+E
Sbjct: 232 GLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQE 291
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP----GLPRNVHVLKVKRNELA 512
L+LS N I ++ DA+ + L LDL+ N L L GL ++ L + N ++
Sbjct: 292 LHLSQNAIN--RISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSL-LNTLHIGNNRVS 348
Query: 513 ALARGALVGMAQLRELYLTSNRLRSRALGPR-AWVDLAHLQLLDIAGNQLTEIPE----G 567
+A A G++ L+ L L +N + A+ L L+ L + GN++ I + G
Sbjct: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408
Query: 568 LPESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 606
L ++LE+L L +N I ++ NAF L+ + L + L
Sbjct: 409 L-DALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 120 bits (302), Expect = 3e-27
Identities = 119/385 (30%), Positives = 178/385 (46%), Gaps = 52/385 (13%)
Query: 199 LYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKL------A 252
++ ++ +L P +P ++ F T + FG PNL V N +L A
Sbjct: 33 VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDA 92
Query: 253 DAGLP---DNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSEL 309
GLP D GSS L LS+N ++ +L KL L N LE +P G F L
Sbjct: 93 FGGLPRLEDLEVTGSS---FLNLSTNIFSNLT-----SLGKLTLNFNMLEALPEGLFQHL 144
Query: 310 SSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEK 366
++L L+LQ N L + L F L+ L+ L+L+ N L+++P L SL L L
Sbjct: 145 AALESLHLQGNQL--QALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSN 202
Query: 367 NAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGL 426
NA+ + V + SL+ L L SN + E + P F L L + L NA+ +P +
Sbjct: 203 NALSGLPQGVFGKLGSLQELFLDSNNISE--LPPQVFSQLFCLERLWLQRNAITHLPLSI 260
Query: 427 PRRVRTLMILH---NQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
+ L L N + + FA T L L+L++N++ + V F L LRSL
Sbjct: 261 FASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLET--VAEGTFAHLSNLRSL 318
Query: 484 DLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPR 543
LS N + LP G+ R++ +L +LYL SN L AL P
Sbjct: 319 MLSYNAITHLPAGIFRDLE---------------------ELVKLYLGSNNLT--ALHPA 355
Query: 544 AWVDLAHLQLLDIAGNQLTEIPEGL 568
+ +L+ L+LL ++ NQLT +PEG+
Sbjct: 356 LFQNLSKLELLSLSKNQLTTLPEGI 380
Score = 104 bits (259), Expect = 3e-22
Identities = 112/415 (26%), Positives = 172/415 (41%), Gaps = 83/415 (20%)
Query: 113 AVSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQ-------------------- 152
A CP C C + V C +L P D+P +T ++
Sbjct: 19 AQPCPMGCDCFVQEVF-CSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
Query: 153 ----NNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
N QL + P+ L RLE L + + + L F +LT+L L L N L
Sbjct: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN--LSTNIFSNLTSLGKLTLNFNMLEA 135
Query: 209 APRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVE 268
P L F L S++L N+L LP +F ++++
Sbjct: 136 LPEGL---------------------FQHLAALESLHLQGNQLQ--ALPRRLFQPLTHLK 172
Query: 269 VLILSSNFLRHVPK---HLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDE 325
L L+ N L +P+ H +L L L NN L +P G F +L SL+EL+L +N +++
Sbjct: 173 TLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE- 231
Query: 326 GLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRS---LVLLHLEKNAIRSVDANVLTPIRS 382
L + F +L LE L L N ++ +P + S L L L+ N +R + A +
Sbjct: 232 -LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC 290
Query: 383 LEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITG 442
L L L NQL + + F L L ++ L NA+ +P+G+ R + L+
Sbjct: 291 LVGLSLTHNQL--ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELV-------- 340
Query: 443 IGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGL 497
+L L N +T+ +H F+ L L L LS N+L TLP G+
Sbjct: 341 -------------KLYLGSNNLTA--LHPALFQNLSKLELLSLSKNQLTTLPEGI 380
Score = 93.6 bits (231), Expect = 5e-19
Identities = 104/357 (29%), Positives = 163/357 (45%), Gaps = 46/357 (12%)
Query: 286 PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSS 345
P L K+ N +L + P AF L L +L + + + L F L+SL L L+
Sbjct: 73 PNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN--LSTNIFSNLTSLGKLTLNF 130
Query: 346 NNLSRVPAGLPRSLVLL---HLEKNAIRSVDANVLTPIRSLEYLLLHSN---QLREQGIH 399
N L +P GL + L L HL+ N ++++ + P+ L+ L L N QL E+ H
Sbjct: 131 NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFH 190
Query: 400 PLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILH---NQITGIGREDFATTYFLEE 456
PL L T+ L NNAL +P G+ ++ +L L N I+ + + F+ + LE
Sbjct: 191 PLT-----SLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
L L N IT + F L L L L N L LP GL +
Sbjct: 246 LWLQRNAIT--HLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTP-------------- 289
Query: 517 GALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYL- 575
LVG++ LT N+L + A G + L++L+ L ++ N +T +P G+ LE L
Sbjct: 290 -CLVGLS------LTHNQLETVAEG--TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELV 340
Query: 576 --YLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
YL +N ++A+ F + L+ + L N+L ++ + F +L L + GN
Sbjct: 341 KLYLGSNNLTALHPALFQNLSKLELLSLSKNQLT--TLPEGIFDTNYNLFNLALHGN 395
Score = 77.4 bits (189), Expect = 4e-14
Identities = 77/296 (26%), Positives = 137/296 (46%), Gaps = 17/296 (5%)
Query: 344 SSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403
S L+ VP +P + + + +++ +L ++ + QL + P AF
Sbjct: 36 SDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQ--FRPDAF 93
Query: 404 QGLKRLHTVHLYNNALERVPSGLPRRVRTLMIL---HNQITGIGREDFATTYFLEELNLS 460
GL RL + + ++ + + + + +L L N + + F LE L+L
Sbjct: 94 GGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQ 153
Query: 461 YNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPR---NVHVLKVKRNELAALARG 517
N++ + + R F+ L L++L+L+ N L LP L ++ LK+ N L+ L +G
Sbjct: 154 GNQLQA--LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQG 211
Query: 518 ALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESL---EY 574
+ L+EL+L SN + L P+ + L L+ L + N +T +P + SL +
Sbjct: 212 VFGKLGSLQELFLDSNNISE--LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
Query: 575 LYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L LQ N + +PA F TP L G+ L N+L +V + F L +L+ L + N
Sbjct: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLE--TVAEGTFAHLSNLRSLMLSYN 323
Score = 49.7 bits (117), Expect = 9e-06
Identities = 47/169 (27%), Positives = 75/169 (44%), Gaps = 7/169 (4%)
Query: 483 LDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGP 542
++ S L T G N+ + +L A G+ +L +L +T + + L
Sbjct: 57 VETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN--LST 114
Query: 543 RAWVDLAHLQLLDIAGNQLTEIPEGLPE---SLEYLYLQNNKISAVPANAFDSTPNLKGI 599
+ +L L L + N L +PEGL + +LE L+LQ N++ A+P F +LK +
Sbjct: 115 NIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTL 174
Query: 600 FLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDISKDRGRLGKEKE 648
L N LA + + F L LQ L + N G G+LG +E
Sbjct: 175 NLAQNLLA--QLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221
>gi|4505047 lumican precursor [Homo sapiens]
Length = 338
Score = 120 bits (300), Expect = 5e-27
Identities = 91/313 (29%), Positives = 156/313 (49%), Gaps = 14/313 (4%)
Query: 110 GPAAVSCPRDCAC--SQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRL 167
G ++ +C +C C S + C + L+ P +P +L L+NNQ++ I + +
Sbjct: 31 GQSSPNCAPECNCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENV 89
Query: 168 HRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYL 227
L+ L L +N L + + + F L L L++ +N LT + LP +L + N +
Sbjct: 90 TDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKI 149
Query: 228 TKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPA 287
TK+ +F NL ++L +N+L + + F G ++E L LS N + +P LP +
Sbjct: 150 TKLG--SFEGLVNLTFIHLQHNRLKEDAV-SAAFKGLKSLEYLDLSFNQIARLPSGLPVS 206
Query: 288 LYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNN 347
L L+L NNK+ IP F ++L+ L L +N L D G+ +F +SSL LDLS N
Sbjct: 207 LLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSF-NVSSLVELDLSYNK 265
Query: 348 LSRVPAGLPRSLVLLHLEKNAIRSVD----ANVLTPI--RSLEYLLLHSNQLREQGIHPL 401
L +P + +L +LE N + D +L P+ +++L L N++ E + P
Sbjct: 266 LKNIPT-VNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPD 324
Query: 402 AFQGLKRLHTVHL 414
++ L+ + V L
Sbjct: 325 MYECLRVANEVTL 337
Score = 94.4 bits (233), Expect = 3e-19
Identities = 67/212 (31%), Positives = 112/212 (52%), Gaps = 5/212 (2%)
Query: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478
L+ VP +P ++ L + +NQI I + F L+ L L +N + + ++ F KL+
Sbjct: 58 LKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLK 116
Query: 479 LLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSR 538
L+ L ++ N L LP+++ L++ N++ L G+ G+ L ++L NRL+
Sbjct: 117 QLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRLKED 174
Query: 539 ALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPNLKG 598
A+ A+ L L+ LD++ NQ+ +P GLP SL LYL NNKIS +P F L+
Sbjct: 175 AVSA-AFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQY 233
Query: 599 IFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ L N+LA + ++F + L LD+ N
Sbjct: 234 LRLSHNELADSGIPGNSF-NVSSLVELDLSYN 264
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 117 bits (294), Expect = 3e-26
Identities = 87/286 (30%), Positives = 145/286 (50%), Gaps = 12/286 (4%)
Query: 277 LRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLS 336
L+++P +P + ++ +NN++ I G F + L + L N +T + + + F KL
Sbjct: 97 LKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLR 155
Query: 337 SLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQ 396
LE L L NNL+R+P LPRSL LHL+ N I V N L + +L L L N+++E
Sbjct: 156 HLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEV 215
Query: 397 GIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEE 456
G + +GL+ L + L N L +VP GLP + L + HN + + F L
Sbjct: 216 G---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLY 272
Query: 457 LNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALAR 516
+ LS+N +T+ + + F LL LDLS N+L +PP + N+ L ++ N + +
Sbjct: 273 VRLSHNSLTNNGLASNTFNSSSLL-ELDLSYNQLQKIPP-VNTNLENLYLQGNRINEFSI 330
Query: 517 GA------LVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDI 556
+ +V ++L+ L L N ++ A+ A + L L++I
Sbjct: 331 SSFCTVVDVVNFSKLQVLRLDGNEIKRSAMPADAPLCLRLASLIEI 376
Score = 115 bits (287), Expect = 2e-25
Identities = 88/304 (28%), Positives = 143/304 (47%), Gaps = 18/304 (5%)
Query: 103 SPEEPGPGPAAVSCPRDCACSQE--GVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIY 160
SP P P CP++C C + C +L+ P +P ++ QNNQ+ I
Sbjct: 67 SPSPPDPR----DCPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQITSIQ 121
Query: 161 PEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISV 220
L + L N++TS + K F L +L LYL +N LT P LP +L +
Sbjct: 122 EGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLREL 181
Query: 221 DFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHV 280
N ++++ NL ++YL +N++ + G + G ++ +L LS N LR V
Sbjct: 182 HLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHLRKV 238
Query: 281 PKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEY 340
P LP AL +L++++N + +P F L + L +N LT+ GL + TF SSL
Sbjct: 239 PDGLPSALEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTF-NSSSLLE 297
Query: 341 LDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPI------RSLEYLLLHSNQLR 394
LDLS N L ++P + +L L+L+ N I + + L+ L L N+++
Sbjct: 298 LDLSYNQLQKIPP-VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIK 356
Query: 395 EQGI 398
+
Sbjct: 357 RSAM 360
Score = 107 bits (266), Expect = 5e-23
Identities = 86/293 (29%), Positives = 135/293 (46%), Gaps = 12/293 (4%)
Query: 199 LYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPD 258
+Y N L P F+P+ + V F N +T I F L + LH N++ +
Sbjct: 90 MYCDNRNLKYLP-FVPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGR 148
Query: 259 NMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQ 318
+F+ ++E L L N L +P LP +L +LHL +N++ ++P A L +L LYLQ
Sbjct: 149 KVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQ 208
Query: 319 NNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLT 378
+N + + G + L SL LDLS N+L +VP GLP +L L++E N + +V +
Sbjct: 209 HNEIQEVG---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFR 265
Query: 379 PIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHN 438
L Y+ L N L G+ F L + L N L+++P + + L + N
Sbjct: 266 GAPKLLYVRLSHNSLTNNGLASNTFNSSSLLE-LDLSYNQLQKIPP-VNTNLENLYLQGN 323
Query: 439 QITGIGREDFATTY------FLEELNLSYNRITSPQVHRDAFRKLRLLRSLDL 485
+I F T L+ L L N I + DA LRL +++
Sbjct: 324 RINEFSISSFCTVVDVVNFSKLQVLRLDGNEIKRSAMPADAPLCLRLASLIEI 376
Score = 105 bits (263), Expect = 1e-22
Identities = 72/215 (33%), Positives = 109/215 (50%), Gaps = 5/215 (2%)
Query: 416 NNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFR 475
N L+ +P +P R++ + +NQIT I F L + L N+ITS +V R F
Sbjct: 94 NRNLKYLPF-VPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFS 152
Query: 476 KLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRL 535
KLR L L L N L +P LPR++ L + N+++ + AL G+ L LYL N +
Sbjct: 153 KLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEI 212
Query: 536 RSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFDSTPN 595
+ R L L LLD++ N L ++P+GLP +LE LY+++N + VP + F P
Sbjct: 213 QEVGSSMRG---LRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPK 269
Query: 596 LKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
L + L N L + + F L+ LD+ N
Sbjct: 270 LLYVRLSHNSLTNNGLASNTFNSSSLLE-LDLSYN 303
Score = 102 bits (254), Expect = 1e-21
Identities = 79/264 (29%), Positives = 129/264 (48%), Gaps = 10/264 (3%)
Query: 345 SNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQ 404
+ NL +P +P + ++ + N I S+ V L ++ LH NQ+ + F
Sbjct: 94 NRNLKYLPF-VPSRMKYVYFQNNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFS 152
Query: 405 GLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRI 464
L+ L ++L +N L R+P LPR +R L + HNQI+ + L L L +N I
Sbjct: 153 KLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEI 212
Query: 465 TSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQ 524
Q + R LR L LDLS N L +P GLP + L ++ N + + G +
Sbjct: 213 ---QEVGSSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYMEHNNVYTVPDSYFRGAPK 269
Query: 525 LRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISA 584
L + L+ N L + L + + L+L D++ NQL +IP + +LE LYLQ N+I+
Sbjct: 270 LLYVRLSHNSLTNNGLASNTFNSSSLLEL-DLSYNQLQKIPP-VNTNLENLYLQGNRINE 327
Query: 585 VPANAFDSTPNLKGIFLRFNKLAV 608
++F + ++ + F+KL V
Sbjct: 328 FSISSFCTVVDV----VNFSKLQV 347
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 114 bits (285), Expect = 3e-25
Identities = 116/370 (31%), Positives = 180/370 (48%), Gaps = 44/370 (11%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
L LQNNQL I E L L L++L L N ++ +PE++FE L++L +L+L +N LT
Sbjct: 67 LMLQNNQLGGIPAEALWELPSLQSLRLDANLISL--VPERSFEGLSSLRHLWLDDNALTE 124
Query: 209 AP-RFLPN--ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
P R L N AL ++ A N ++ I F +L ++LHNN++ G + F G
Sbjct: 125 IPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG--THSFEGLH 182
Query: 266 NVEVLILSSNFLRHVPKHLPP--ALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLT 323
N+E L L+ N L+ P + L +L NN ++ IP AF L+ ++ +N +
Sbjct: 183 NLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQ 242
Query: 324 DEGLDNETFWKLSSLEYLDLS-SNNLSRVP-AGLPRSLVLLHLEKNAIRSVDANVLTPIR 381
G F L L L L+ + ++ P SL +L L + IR + + +
Sbjct: 243 FVG--RSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC---- 296
Query: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPS-GLPRRVRTLMILHNQI 440
Q L RL + L +N +E +PS +++ + + HN+I
Sbjct: 297 ----------------------QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRI 334
Query: 441 TGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP-PGLPR 499
IG + F+ L+ L+LS+N I S +H +AF L L LDL+ N+L TLP GL
Sbjct: 335 WEIGADTFSQLSSLQALDLSWNAIRS--IHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGG 392
Query: 500 NVHVLKVKRN 509
+H LK+K N
Sbjct: 393 LMH-LKLKGN 401
Score = 111 bits (277), Expect = 2e-24
Identities = 126/458 (27%), Positives = 213/458 (46%), Gaps = 36/458 (7%)
Query: 221 DFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHV 280
D + N LT++ F L + L N L+ +P F+G ++++L+L +N L +
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSH--IPGQAFSGLYSLKILMLQNNQLGGI 77
Query: 281 PKHLP---PALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSS 337
P P+L L L N + +P +F LSSLR L+L +N LT+ + L +
Sbjct: 78 PAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTE--IPVRALNNLPA 135
Query: 338 LEYLDLSSNNLSRVPAGLPR---SLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLR 394
L+ + L+ N +S +P + SLV+LHL N I+ + + + +LE L L+ N+L+
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
Query: 395 EQGIHPLAFQGLKRLHTVHLYNNALERVPS----GLPRRVRTLMILHNQITGIGREDFAT 450
E P+A + L RL + +NN ++ +P G P ++T+ N I +GR F
Sbjct: 196 E---FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP-LLQTIHFYDNPIQFVGRSAF-- 249
Query: 451 TYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPG----LPRNVHVLKV 506
Y + LS N Q D + L L L+ + LP G LPR + VL++
Sbjct: 250 QYLPKLHTLSLNGAMDIQEFPD-LKGTTSLEILTLTRAGIRLLPSGMCQQLPR-LRVLEL 307
Query: 507 KRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEI-P 565
N++ L +L +L E+ L NR+ +G + L+ LQ LD++ N + I P
Sbjct: 308 SHNQIEELP--SLHRCQKLEEIGLQHNRIWE--IGADTFSQLSSLQALDLSWNAIRSIHP 363
Query: 566 EGLP--ESLEYLYLQNNKISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQ 623
E SL L L +N+++ +P +LK L+ N + +F +L+ L+
Sbjct: 364 EAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGNLALSQAFSKDSFPKLRILE 420
Query: 624 VLDIEGNLEFGDISKDRGRLGKEKEEEEEEEEEEEETR 661
V +G + G+ + E+ ++EE R
Sbjct: 421 VPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKR 458
Score = 76.6 bits (187), Expect = 7e-14
Identities = 80/276 (28%), Positives = 128/276 (46%), Gaps = 22/276 (7%)
Query: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTL 208
L L NN+++ + LH LETL+L N+L + A L L L NN +
Sbjct: 163 LHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV---AIRTLGRLQELGFHNNNIKA 219
Query: 209 APR--FLPNALI-SVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
P F+ N L+ ++ F N + + F P L ++ L N + PD G++
Sbjct: 220 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL-NGAMDIQEFPD--LKGTT 276
Query: 266 NVEVLILSSNFLRHVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
++E+L L+ +R +P + P L L L +N++E++P + L E+ LQ+N +
Sbjct: 277 SLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRI 334
Query: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRV-PAGLP--RSLVLLHLEKNAIRSVDANVLTP 379
+ G D TF +LSSL+ LDLS N + + P SLV L L N + ++ L
Sbjct: 335 WEIGAD--TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP---LAG 389
Query: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLY 415
+ L +L L N Q +F L+ L + Y
Sbjct: 390 LGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAY 425
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 12/159 (7%)
Query: 479 LLRSLDLSGNRLHTLPPGL---PRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRL 535
++ + DLS N L L PGL R + L++ N L+ + A G+ L+ L L +N+L
Sbjct: 15 IISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQL 74
Query: 536 RSRALGPRAWVDLAHLQLLDIAGNQLTEIP----EGLPESLEYLYLQNNKISAVPANAFD 591
+ A +L LQ L + N ++ +P EGL SL +L+L +N ++ +P A +
Sbjct: 75 --GGIPAEALWELPSLQSLRLDANLISLVPERSFEGL-SSLRHLWLDDNALTEIPVRALN 131
Query: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
+ P L+ + L N+ + + D AF+ L L VL + N
Sbjct: 132 NLPALQAMTLALNR--ISHIPDYAFQNLTSLVVLHLHNN 168
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,918,273
Number of Sequences: 37866
Number of extensions: 1468003
Number of successful extensions: 21300
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 186
Number of HSP's that attempted gapping in prelim test: 13199
Number of HSP's gapped (non-prelim): 3898
length of query: 661
length of database: 18,247,518
effective HSP length: 109
effective length of query: 552
effective length of database: 14,120,124
effective search space: 7794308448
effective search space used: 7794308448
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.