Search of human proteins with 4507001

Search of human proteins with 4507001

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
         (555 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507001 solute carrier family 22 member 2 [Homo sapiens]          1134   0.0  
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap...   813   0.0  
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa...   698   0.0  
gi|11415038 solute carrier family 22 member 3 [Homo sapiens]          572   e-163
gi|24497499 solute carrier family 22 member 8 [Homo sapiens]          281   1e-75
gi|4507005 solute carrier family 22 member 5 [Homo sapiens]           275   1e-73
gi|24497490 solute carrier family 22 member 4 [Homo sapiens]          266   4e-71
gi|166064021 solute carrier family 22 (organic anion transporter...   262   7e-70
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa...   261   9e-70
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa...   261   2e-69
gi|31542327 solute carrier family 22, member 16 [Homo sapiens]        240   2e-63
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa...   234   2e-61
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa...   229   5e-60
gi|238814326 solute carrier family 22, member 20 [Homo sapiens]       228   9e-60
gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]          223   3e-58
gi|166197673 solute carrier family 22, member 15 [Homo sapiens]       222   8e-58
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa...   218   9e-57
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa...   218   2e-56
gi|8923870 solute carrier family 22 member 11 [Homo sapiens]          207   2e-53
gi|148664184 solute carrier family 22, member 10 [Homo sapiens]       207   2e-53
gi|211059435 solute carrier family 22, member 24 [Homo sapiens]       205   1e-52
gi|157426885 organic cation transporter like 4 [Homo sapiens]         188   1e-47
gi|42542386 solute carrier family 22 (organic anion/cation trans...   187   2e-47
gi|153791484 putative UST1-like organic anion transporter [Homo ...   173   3e-43
gi|24308167 SV2 related protein [Homo sapiens]                        152   6e-37
gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]          146   6e-35
gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6...   144   2e-34
gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1...   141   1e-33
gi|63999576 solute carrier family 22, member 17 isoform b [Homo ...   124   3e-28
gi|213021148 SVOP-like isoform 1 [Homo sapiens]                       119   7e-27

>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
          Length = 555

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 555/555 (100%), Positives = 555/555 (100%)

Query: 1   MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS 60
           MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS
Sbjct: 1   MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELS 60

Query: 61  LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG 120
           LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG
Sbjct: 61  LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG 120

Query: 121 PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180
           PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL
Sbjct: 121 PCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180

Query: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF 240
           LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF
Sbjct: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF 240

Query: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300
           YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM
Sbjct: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300

Query: 301 RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360
           RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV
Sbjct: 301 RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360

Query: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA 420
           LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA
Sbjct: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA 420

Query: 421 SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII 480
           SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII
Sbjct: 421 SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII 480

Query: 481 TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE 540
           TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE
Sbjct: 481 TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE 540

Query: 541 KMIYLQVQKLDIPLN 555
           KMIYLQVQKLDIPLN
Sbjct: 541 KMIYLQVQKLDIPLN 555


>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
           sapiens]
          Length = 554

 Score =  813 bits (2100), Expect = 0.0
 Identities = 385/545 (70%), Positives = 447/545 (82%)

Query: 4   TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRC 63
           TVDD+LE  GE  +FQKQ F +L LLSA FAPI VGIVFLGFTPDH C+SPGVAELS RC
Sbjct: 3   TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123
           GWSPAEELNYTVPG GPAGEA   QCRRYEVDWNQS   CVDPLASL TNRS LPLGPC+
Sbjct: 63  GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122

Query: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
           DGWVY+TPGSSIVTEFNLVCA+SW LDLFQS +N GF  GS+ +GY ADRFGRKLCLL T
Sbjct: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
           VL+NA +GVLMA SP Y  ML+FRL+QGLVSK  W+ GY LITEFVG   RRTV I YQ+
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303
           A+TVGL+ L G+AYALPHWRWLQ  V+LP F FLLYYWC+PESPRWL+SQ +N EA++I+
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 304 KHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQ 363
            HIA+KNGK  PA L+ L LEE+  +KL+PSF DL RTP++RK T ILMY WFT SVLYQ
Sbjct: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 364 GLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVF 423
           GLI+HMG    N+YLDF YSALVE P AF+ ++TIDR+GR YP A SN++AGAACL  +F
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 424 IPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPF 483
           I  DL WL III C+GRMGIT+A +++CLVNAELYPTF+RNLGV +CSS+CDIGGIITPF
Sbjct: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPF 482

Query: 484 LVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMI 543
           +V+RL  +W  LPL++F VLGL+A G+ LLLPETKG ALPET+++AEN+ R  K KE  I
Sbjct: 483 IVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVALPETMKDAENLGRKAKPKENTI 542

Query: 544 YLQVQ 548
           YL+VQ
Sbjct: 543 YLKVQ 547


>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
           sapiens]
          Length = 506

 Score =  698 bits (1801), Expect = 0.0
 Identities = 329/463 (71%), Positives = 378/463 (81%)

Query: 4   TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRC 63
           TVDD+LE  GE  +FQKQ F +L LLSA FAPI VGIVFLGFTPDH C+SPGVAELS RC
Sbjct: 3   TVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSPGVAELSQRC 62

Query: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123
           GWSPAEELNYTVPG GPAGEA   QCRRYEVDWNQS   CVDPLASL TNRS LPLGPC+
Sbjct: 63  GWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQ 122

Query: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
           DGWVY+TPGSSIVTEFNLVCA+SW LDLFQS +N GF  GS+ +GY ADRFGRKLCLL T
Sbjct: 123 DGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGT 182

Query: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
           VL+NA +GVLMA SP Y  ML+FRL+QGLVSK  W+ GY LITEFVG   RRTV I YQ+
Sbjct: 183 VLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM 242

Query: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303
           A+TVGL+ L G+AYALPHWRWLQ  V+LP F FLLYYWC+PESPRWL+SQ +N EA++I+
Sbjct: 243 AFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIM 302

Query: 304 KHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQ 363
            HIA+KNGK  PA L+ L LEE+  +KL+PSF DL RTP++RK T ILMY WFT SVLYQ
Sbjct: 303 DHIAQKNGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQ 362

Query: 364 GLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVF 423
           GLI+HMG    N+YLDF YSALVE P AF+ ++TIDR+GR YP A SN++AGAACL  +F
Sbjct: 363 GLILHMGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIF 422

Query: 424 IPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLG 466
           I  DL WL III C+GRMGIT+A +++CLVNAELYPTF+  +G
Sbjct: 423 ISPDLHWLNIIIMCVGRMGITIAIQMICLVNAELYPTFVSGVG 465


>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
          Length = 556

 Score =  572 bits (1473), Expect = e-163
 Identities = 275/542 (50%), Positives = 382/542 (70%), Gaps = 12/542 (2%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR-CRSPGVAELSLRCG 64
           D+ L+  GEF  FQ+++F LL L   TFA ++VG+VFLG  PDH  CR P  A L+ RCG
Sbjct: 5   DEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCG 64

Query: 65  WSPAEELNYTVPGP-GPAGEASPRQCRRYEVDWNQ------STFDCVDPLASLDTNRSRL 117
           WSP EE N T P   GP       +C+RY ++         S   C DPLA+   NRS  
Sbjct: 65  WSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFP-NRSA- 122

Query: 118 PLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRK 177
           PL PCR GW Y    S+IV+EF+LVC N+WMLDL Q+ +N+GF  G+ ++GY ADR+GR 
Sbjct: 123 PLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI 182

Query: 178 LCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTV 237
           +  L + L     GV++A +P +   +IFR +QG+  K  W+  Y+++TE VG + RR V
Sbjct: 183 VIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV 242

Query: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297
           GI  Q+ +T+G+++L G+AY +P+W+ +Q  + LP+F FLLYYW +PESPRWLI++ K  
Sbjct: 243 GIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGD 302

Query: 298 EAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFT 357
           +A++I++ IAK NGK L ++   + + +E  +  NPSFLDLVRTPQ+RK T+ILM+ WFT
Sbjct: 303 KALQILRRIAKCNGKYLSSNYSEITVTDE--EVSNPSFLDLVRTPQMRKCTLILMFAWFT 360

Query: 358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAA 417
           S+V+YQGL+M +G+ G N+Y+DFF S +VE P A +I+LTI+R+GRR P+AASN+VAG A
Sbjct: 361 SAVVYQGLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVA 420

Query: 418 CLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG 477
           CL + F+P  + WL+  ++ LGR+GITMA+EIV LVN+ELYPT +RN GV +CS +CD G
Sbjct: 421 CLVTAFLPEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFG 480

Query: 478 GIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRK 537
           GII PFL++RL  +WLELPL++FG+L  + GGLV+LLPETKG ALPET+++ E +  P  
Sbjct: 481 GIIAPFLLFRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS 540

Query: 538 NK 539
            K
Sbjct: 541 CK 542


>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
          Length = 542

 Score =  281 bits (719), Expect = 1e-75
 Identities = 182/545 (33%), Positives = 282/545 (51%), Gaps = 33/545 (6%)

Query: 4   TVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRC 63
           T  ++L+  G    FQ     +L L     A   +  +F   TP H CR P  A      
Sbjct: 2   TFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTG--- 58

Query: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123
                    + +P  GP G+  P +C R+             P ASL  +  R  + PC 
Sbjct: 59  --------PWVLP-MGPNGK--PERCLRF----------VHPPNASLPNDTQRA-MEPCL 96

Query: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
           DGWVY +   SIVTE++LVC ++ + ++ QS    G  IG + +G ++DRFGR+  L  +
Sbjct: 97  DGWVYNSTKDSIVTEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCS 156

Query: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
            L+ AA+G   A SPT+   ++FR + G       L   IL  E+V  R R  +      
Sbjct: 157 YLLLAASGSGAAFSPTFPIYMVFRFLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGY 216

Query: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303
            YT G  +L G+AYA+P WRWLQ TV++P F F L  W  PES RWL+   K+++A++I+
Sbjct: 217 CYTFGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKIL 276

Query: 304 KHIAKKNGKSLPA---SLQRLRL---EEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFT 357
           + +A  NGK       SL+ L+L   +E +  K   +  DL R P +R+ T  L   WF 
Sbjct: 277 RRVAVFNGKKEEGERLSLEELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFA 336

Query: 358 SSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAA 417
           +   Y  L M +   G N+Y+       V+ PA F+ IL++  +GR    AA+ ++AG A
Sbjct: 337 TGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396

Query: 418 CLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG 477
            LA  F+P DLQ ++ +++  G+  ++ ++  + L  +ELYPT IR  G+ + +    +G
Sbjct: 397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVG 456

Query: 478 GIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ-RPR 536
            +++P LV     +   +P +++G+  L+ G   L LPET  + LPETIE+ EN   R +
Sbjct: 457 SMVSP-LVKITGEVQPFIPNIIYGITALLGGSAALFLPETLNQPLPETIEDLENWSLRAK 515

Query: 537 KNKEK 541
           K K++
Sbjct: 516 KPKQE 520


>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
          Length = 557

 Score =  275 bits (702), Expect = 1e-73
 Identities = 184/533 (34%), Positives = 281/533 (52%), Gaps = 24/533 (4%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPI-YVGI--VFLGFTPDHRCRSPGVAELSLR 62
           D+V    GE+  FQ+ +FFLL   SA+  P  + G+  VFL  TP+HRCR P  A LS  
Sbjct: 5   DEVTAFLGEWGPFQRLIFFLL---SASIIPNGFTGLSSVFLIATPEHRCRVPDAANLS-- 59

Query: 63  CGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPC 122
             W      N+TVP     G   P  CRRY +    + F  +      D +  +L    C
Sbjct: 60  SAWR-----NHTVPLRLRDGREVPHSCRRYRLA-TIANFSALGLEPGRDVDLGQLEQESC 113

Query: 123 RDGWVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180
            DGW +      S+IVTE+NLVC + W   L  S   VG  +GS   G ++DRFGRK  L
Sbjct: 114 LDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVL 173

Query: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR---RTV 237
             T+ +      L   S  +   ++  ++ G+   + ++  ++L TE +G+  R    T+
Sbjct: 174 FVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTL 233

Query: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297
           G+   + Y  G +VL   AY +  WR L   + +P    +  +W IPESPRWLISQ +  
Sbjct: 234 GVC--IFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFE 291

Query: 298 EAMRIIKHIAKKNGKSLPASL-QRLRLEEETGKKLNP-SFLDLVRTPQIRKHTMILMYNW 355
           EA  II+  AK NG  +P+++     L++ + KK    + LDL+RT  IR  T++ +  W
Sbjct: 292 EAEVIIRKAAKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLW 351

Query: 356 FTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAG 415
            T SV Y GL +       +I+++ F SA+VE PA  +  L +  + RRY  A +  + G
Sbjct: 352 MTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGG 411

Query: 416 AACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCD 475
           +  L    +P DL +L  ++  +G+ G+T A+ +V +  AELYPT +RN+GV + S+   
Sbjct: 412 SVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASR 471

Query: 476 IGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEE 528
           +G I++P+ VY L      LP ++ G L ++   L L LPE+ G  LP+TI++
Sbjct: 472 LGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQ 523


>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
          Length = 551

 Score =  266 bits (680), Expect = 4e-71
 Identities = 181/540 (33%), Positives = 270/540 (50%), Gaps = 16/540 (2%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGW 65
           D+V+   GE+  FQ+ +FFLL+          + +VFL  TP+HRCR P  A LS    W
Sbjct: 5   DEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLS--SAW 62

Query: 66  SPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDG 125
                 N +VP     G   P  C RY +    + F  +      D +  +L    C DG
Sbjct: 63  R-----NNSVPLRLRDGREVPHSCSRYRLA-TIANFSALGLEPGRDVDLGQLEQESCLDG 116

Query: 126 WVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
           W +      S++VTE+NLVC ++W + L  S   VG  +GS   G ++DRFGRK  L  T
Sbjct: 117 WEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFAT 176

Query: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR---RTVGIF 240
           + +      L   S ++    +  +I G+   + +++ +IL TE +G+  R    T+G+ 
Sbjct: 177 MAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVC 236

Query: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300
               + VG ++L   AY +  WR L   + +P    +  +W IPESPRWLISQ +  EA 
Sbjct: 237 --TFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAE 294

Query: 301 RIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360
            II+  AK N  ++PA +     E    K+     LDL RT  I   T++ +  W  +SV
Sbjct: 295 DIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFRTRNIAIMTIMSLLLWMLTSV 354

Query: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLA 420
            Y  L +       + YL+ F SAL+E PA     L +  + RRY  AA     G   L 
Sbjct: 355 GYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLF 414

Query: 421 SVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGII 480
              +P D  +L I +  LG+ GIT A+ ++ +  AELYPT +RN+ V + S+   +G II
Sbjct: 415 IQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSII 474

Query: 481 TPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKE 540
            P+ VY L      LP +V G L ++ G L L  PE+ G  LPET+E+ + ++  R  K+
Sbjct: 475 APYFVY-LGAYNRMLPYIVMGSLTVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKK 533


>gi|166064021 solute carrier family 22 (organic anion transporter),
           member 13 [Homo sapiens]
          Length = 551

 Score =  262 bits (669), Expect = 7e-70
 Identities = 171/533 (32%), Positives = 263/533 (49%), Gaps = 16/533 (3%)

Query: 8   VLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSP 67
           VL   G+F  FQ Q+  LL +L+      +   VF+     H C    V   +     S 
Sbjct: 7   VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNL--SA 64

Query: 68  AEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWV 127
           AE+L  +VP    AG   P  C  +      ++   +  + S   N ++    PC  GW 
Sbjct: 65  AEQLVLSVP-LDTAGHPEP--CLMFRPPPANAS---LQDILSHRFNETQ----PCDMGWE 114

Query: 128 Y-ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLI 186
           Y E    S+  EFNLVC    + D  QS    G  +G++  G + DR GRK  +L  +L+
Sbjct: 115 YPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLL 174

Query: 187 NAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYT 246
               G+  A  P++   +  R                L+TE+VG  +R    +  Q  ++
Sbjct: 175 FTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFS 234

Query: 247 VGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHI 306
           +G +VLAG+AY   +WR LQ T   P      Y+W +PES RWL+++ +  EA+++I+  
Sbjct: 235 LGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKA 294

Query: 307 AKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLI 366
           A  N + L   L    + E+TG   N   LDL R PQ+RK T+I+   WF  S+ Y GL 
Sbjct: 295 ASVNRRKLSPELMNQLVPEKTGPSGNA--LDLFRHPQLRKVTLIIFCVWFVDSLGYYGLS 352

Query: 367 MHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPG 426
           + +G  G ++YL       VE PA    I  + R GR++    + ++ G  C+  +FIP 
Sbjct: 353 LQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPA 412

Query: 427 DLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVY 486
           DL  +  +++ +G+M    A+ I  + +AEL+PT +R  G+ +      IGGI+TP LV 
Sbjct: 413 DLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGILTP-LVI 471

Query: 487 RLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNK 539
            L      LP++++G L +VAG L  LLPET G+ L +T+++ E    PR  K
Sbjct: 472 LLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLKDTLQDLELGPHPRSPK 524


>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
           sapiens]
          Length = 550

 Score =  261 bits (668), Expect = 9e-70
 Identities = 178/561 (31%), Positives = 274/561 (48%), Gaps = 36/561 (6%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
           +D+L+  G    FQ+    L+ L     A       F    P H CR P  A LS   G 
Sbjct: 4   NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63

Query: 65  --WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGP 121
             W P +             +  P  C R+    W     +  +   +  T        P
Sbjct: 64  EVWLPRDR------------QGQPESCLRFTSPQWGLPFLNGTEANGTGATE-------P 104

Query: 122 CRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLC 179
           C DGW+Y+  T  S+IVTE++LVC++  +  L QS   VG  +G+M  GY+ADR GR+  
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

Query: 180 LLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGI 239
           L+   L  A +G   A +P +     FRL+ G+      L    L  E++    R  VG 
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224

Query: 240 FYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEA 299
                Y++G  +LAGVAYA+PHWR LQ  V+ P F F +Y W   ES RW  S  +    
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284

Query: 300 MRIIKHIAKKNGK-----SLPASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMY 353
           +R ++ +A+ NGK      L   + R  L++E T  K   S ++L+R P +R   + L  
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344

Query: 354 NWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMV 413
            WF +S  Y GL+M +   G +IYL       V+ PA  +  L I+ +GRR    A+ ++
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404

Query: 414 AGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSM 473
           AG   L +  IP D   ++  ++ LG+  +  ++  + L   ELYPT IR  G+ + S+M
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464

Query: 474 CDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
             +G I++P LV     ++  +PL ++G + + A  + +LLPET G+ LP+T+++ E+  
Sbjct: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLES-- 521

Query: 534 RPRKNKEKMIYLQVQKLDIPL 554
             RK K+     + QK  +PL
Sbjct: 522 --RKGKQTRQQQEHQKYMVPL 540


>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
           sapiens]
          Length = 563

 Score =  261 bits (666), Expect = 2e-69
 Identities = 179/570 (31%), Positives = 275/570 (48%), Gaps = 41/570 (7%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
           +D+L+  G    FQ+    L+ L     A       F    P H CR P  A LS   G 
Sbjct: 4   NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63

Query: 65  --WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGP 121
             W P +             +  P  C R+    W     +  +   +  T        P
Sbjct: 64  EVWLPRDR------------QGQPESCLRFTSPQWGLPFLNGTEANGTGATE-------P 104

Query: 122 CRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLC 179
           C DGW+Y+  T  S+IVTE++LVC++  +  L QS   VG  +G+M  GY+ADR GR+  
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

Query: 180 LLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGI 239
           L+   L  A +G   A +P +     FRL+ G+      L    L  E++    R  VG 
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224

Query: 240 FYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEA 299
                Y++G  +LAGVAYA+PHWR LQ  V+ P F F +Y W   ES RW  S  +    
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284

Query: 300 MRIIKHIAKKNGK-----SLPASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMY 353
           +R ++ +A+ NGK      L   + R  L++E T  K   S ++L+R P +R   + L  
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344

Query: 354 NWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMV 413
            WF +S  Y GL+M +   G +IYL       V+ PA  +  L I+ +GRR    A+ ++
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404

Query: 414 AGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSM 473
           AG   L +  IP D   ++  ++ LG+  +  ++  + L   ELYPT IR  G+ + S+M
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTM 464

Query: 474 CDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
             +G I++P LV     ++  +PL ++G + + A  + +LLPET G+ LP+T+++ E+  
Sbjct: 465 ARVGSIVSP-LVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRW 523

Query: 534 R---------PRKNKEKMIYLQVQKLDIPL 554
                     PRK K+     + QK  +PL
Sbjct: 524 APTQKEAGIYPRKGKQTRQQQEHQKYMVPL 553


>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
          Length = 577

 Score =  240 bits (613), Expect = 2e-63
 Identities = 160/564 (28%), Positives = 271/564 (48%), Gaps = 39/564 (6%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPG-VAELSLRCG 64
           + + +H G F  FQ+ ++F+ A  + +    Y+  VF+G TP H CR PG V+++     
Sbjct: 7   EGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFH-- 64

Query: 65  WSPAEELNYTVPGPGPAGEASPR-----QCRRYEVDWNQSTFDCVDPLASLDTNRSRLPL 119
                  N+++   G    +  +     Q +  E+ W  S         S +   +   L
Sbjct: 65  ----NHSNWSLEDTGALLSSGQKDYVTVQLQNGEI-WELSR-------CSRNKRENTSSL 112

Query: 120 G----------PCRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSI 167
           G          PC DG++Y+  T  S+ VT++NLVC   W+  L Q     G  +GS++ 
Sbjct: 113 GYEYTGSKKEFPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTF 172

Query: 168 GYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITE 227
           GY +DR GR++ L  T       G+  A +  Y   +  R    +V+    ++G++ + E
Sbjct: 173 GYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVME 232

Query: 228 FVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESP 287
           F+G + R    +     + VG L++A   Y +  W   Q  ++     F+L  W +PE+P
Sbjct: 233 FIGMKSRTWASVHLHSFFAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCCWVLPETP 292

Query: 288 RWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLD------LVRT 341
            WL+S+ +  EA +I+  +AK N  S     + L L+ +     +P+ +       L   
Sbjct: 293 FWLLSEGRYEEAQKIVDIMAKWNRASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYN 352

Query: 342 PQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRI 401
             I K T+ +   WFT S+ +    ++    G N YL+ F   +VE PA   + + +D++
Sbjct: 353 WSITKRTLTVWLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKV 412

Query: 402 GRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTF 461
           GRR   A S   +  AC   + IP     L ++ + +G+  I  A+ ++ L  AELYPT 
Sbjct: 413 GRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTI 472

Query: 462 IRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKA 521
           +R+L V   S +C +  I+ PF V  L++IW+ +P +  G + L++G L L LPET GK 
Sbjct: 473 VRSLAVGSGSMVCRLASILAPFSV-DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKR 531

Query: 522 LPETIEEAENMQRPRKNKEKMIYL 545
           L  T EEA  ++   ++K   + L
Sbjct: 532 LATTWEEAAKLESENESKSSKLLL 555


>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
           sapiens]
          Length = 546

 Score =  234 bits (597), Expect = 2e-61
 Identities = 163/551 (29%), Positives = 259/551 (47%), Gaps = 17/551 (3%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGV-AELSLRCG 64
           +++LE  G F  FQ +   LLAL        ++  +FL   P HRC  PG  A  S +  
Sbjct: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63

Query: 65  WSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRD 124
           W  A      +P   P G  S   C R+            +   S           PC  
Sbjct: 64  WLEAH-----LPRE-PDGTLS--SCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115

Query: 125 GWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLT 182
           GW Y+     S+I TE++LVC    +     +    G  +G+++ GY++DRFGR+  LL 
Sbjct: 116 GWEYDHSEFSSTIATEWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLV 175

Query: 183 TVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQ 242
             +     G+  A S +Y    I R + G       +I   L  E++   +R   G+   
Sbjct: 176 AYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSS 235

Query: 243 VAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRI 302
             +T G+++LA V Y +  WRWL   V LP    +L  W +PES RWL++Q    EA R 
Sbjct: 236 TFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRY 295

Query: 303 IKHIAKKNGKSL--PASLQRLRLEEETGKKL--NPSFLDLVRTPQIRKHTMILMYNWFTS 358
           + H A+ NG+ +   +  Q    +   G+++   PS+LDL RTP++R  ++  +  WF  
Sbjct: 296 LLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGV 355

Query: 359 SVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAAC 418
           +  Y GL + +   G N+Y        VE P+  ++ L++   GRR   A + +    A 
Sbjct: 356 NFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAF 415

Query: 419 LASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGG 478
              + +  D++    +++ +G+     A+    L  +ELYPT +R  G+ + + +  +GG
Sbjct: 416 GTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGG 475

Query: 479 IITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRK- 537
            + P L   L  +WL LP + +G + L+A G  LLLPET+   LPETI++ E    P   
Sbjct: 476 SLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSL 534

Query: 538 NKEKMIYLQVQ 548
            +E+M   QVQ
Sbjct: 535 QEEEMPMKQVQ 545


>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
           sapiens]
          Length = 548

 Score =  229 bits (584), Expect = 5e-60
 Identities = 163/553 (29%), Positives = 259/553 (46%), Gaps = 19/553 (3%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGV-AELSLRCG 64
           +++LE  G F  FQ +   LLAL        ++  +FL   P HRC  PG  A  S +  
Sbjct: 4   EELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDV 63

Query: 65  WSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRD 124
           W  A      +P   P G  S   C R+            +   S           PC  
Sbjct: 64  WLEAH-----LPRE-PDGTLS--SCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQ 115

Query: 125 GWVYETP--GSSIVTE--FNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCL 180
           GW Y+     S+I TE  ++LVC    +     +    G  +G+++ GY++DRFGR+  L
Sbjct: 116 GWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLL 175

Query: 181 LTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIF 240
           L   +     G+  A S +Y    I R + G       +I   L  E++   +R   G+ 
Sbjct: 176 LVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVL 235

Query: 241 YQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAM 300
               +T G+++LA V Y +  WRWL   V LP    +L  W +PES RWL++Q    EA 
Sbjct: 236 SSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAH 295

Query: 301 RIIKHIAKKNGKSL--PASLQRLRLEEETGKKL--NPSFLDLVRTPQIRKHTMILMYNWF 356
           R + H A+ NG+ +   +  Q    +   G+++   PS+LDL RTP++R  ++  +  WF
Sbjct: 296 RYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWF 355

Query: 357 TSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGA 416
             +  Y GL + +   G N+Y        VE P+  ++ L++   GRR   A + +    
Sbjct: 356 GVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTAL 415

Query: 417 ACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDI 476
           A    + +  D++    +++ +G+     A+    L  +ELYPT +R  G+ + + +  +
Sbjct: 416 AFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRL 475

Query: 477 GGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPR 536
           GG + P L   L  +WL LP + +G + L+A G  LLLPET+   LPETI++ E    P 
Sbjct: 476 GGSLAP-LAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPT 534

Query: 537 K-NKEKMIYLQVQ 548
              +E+M   QVQ
Sbjct: 535 SLQEEEMPMKQVQ 547


>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
          Length = 555

 Score =  228 bits (582), Expect = 9e-60
 Identities = 178/562 (31%), Positives = 264/562 (46%), Gaps = 38/562 (6%)

Query: 7   DVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPG---VAELSLRC 63
           D+L+  G    FQ     LL L     A       F    P H CR P     A  +   
Sbjct: 5   DLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEASTNDSG 64

Query: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGP-- 121
            W     L  T+P        +P  CRR+             P  +L +  S +P     
Sbjct: 65  AW-----LRATIPLDQLG---APEPCRRF-----------TKPQWALLSPNSSIPGAATE 105

Query: 122 -CRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178
            C+DGWVY      S+IV E++LVC    + DL QS    G  +G+   G +ADR G K 
Sbjct: 106 GCKDGWVYNRSVFPSTIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKG 165

Query: 179 CLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG 238
            L+ + L  AA+G   A   +++   +FR + G+      L    L+ E++  R R   G
Sbjct: 166 PLVWSYLQLAASGAATAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAG 225

Query: 239 IFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAE 298
           I    ++T+G L+LAGVAY +  WR LQF ++ P   F LY W +PES RWL+   K+  
Sbjct: 226 ILLGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQL 285

Query: 299 AMRIIKHIA-----KKNGKSLPASLQRLRLEEETGKK-LNPSFLDLVRTPQIRKHTMILM 352
           A++ ++ +A     K+ G+ L   +    ++ E      + S LDL RTP IRK T  LM
Sbjct: 286 AVQNLQKVAAMNGRKEEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLM 345

Query: 353 YNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNM 412
             WF++SV Y GL M +   G ++YL      ++  PA  +   T+  +GRR   A+  +
Sbjct: 346 VIWFSNSVAYYGLAMDLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLI 405

Query: 413 VAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472
           +AG   +A++F+P   Q L    + LG+  +  ++  V L   ELYPT IR +G+   S 
Sbjct: 406 LAGLMVIANMFVPEGTQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASV 465

Query: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532
              +GG+  P LV  L      LP + FG   ++AG  V +L ET+   L ETI   E  
Sbjct: 466 HARLGGLTAP-LVTTLGEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERR 524

Query: 533 QRPRKNK----EKMIYLQVQKL 550
            +   +K    EK   + +Q+L
Sbjct: 525 VKEGSSKKHVEEKSEEISLQQL 546


>gi|24497485 urate anion exchanger 1 isoform a [Homo sapiens]
          Length = 553

 Score =  223 bits (569), Expect = 3e-58
 Identities = 155/505 (30%), Positives = 248/505 (49%), Gaps = 27/505 (5%)

Query: 42  FLGFTPDHRCRSP----GVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWN 97
           F    P HRC +P      A+ S+    SP   L  ++P PGP     P QCRR+     
Sbjct: 40  FSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIP-PGP--NQRPHQCRRFR---- 92

Query: 98  QSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSS 155
           Q  +  +DP A+  T+ S     PC DGWVY+     S+IV ++NLVC +  +  + QS 
Sbjct: 93  QPQWQLLDPNATA-TSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSI 151

Query: 156 VNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSK 215
              G  +G+ + G  +DRFGR+L L  + L  A  G   A +P +    +FR +      
Sbjct: 152 YLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVA 211

Query: 216 AGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFF 275
              +    L+ E+   R R  V     + ++ G  + A VAY +  W  LQ  V++P F 
Sbjct: 212 GVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFL 271

Query: 276 FLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGK-----SLPASLQRLRLEEETGKK 330
             LY W + ES RWL++  +    ++ +  +A  NGK     +L   +    + EE    
Sbjct: 272 CFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMG 331

Query: 331 LNPSFLD-LVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFP 389
             P+ L  L+R P +R  T I    WF     + GL + +   G NI+L   +  +V+ P
Sbjct: 332 QPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIP 391

Query: 390 AAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEI 449
           A    +L +  +GRR   AAS ++AG   LA+  +P ++  L+  ++ LG  G+  A+  
Sbjct: 392 AKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTC 451

Query: 450 VCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNI---WLELPLMVFGVLGLV 506
           + + ++EL+PT +R   V +       G I+ P +  RL  +   W  LPL+V+G + ++
Sbjct: 452 ITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLV--RLLGVHGPW--LPLLVYGTVPVL 507

Query: 507 AGGLVLLLPETKGKALPETIEEAEN 531
           +G   LLLPET+   LP+TI++ +N
Sbjct: 508 SGLAALLLPETQSLPLPDTIQDVQN 532


>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
          Length = 547

 Score =  222 bits (565), Expect = 8e-58
 Identities = 175/559 (31%), Positives = 261/559 (46%), Gaps = 58/559 (10%)

Query: 5   VDDVLEHGGEFHFFQKQMFFLLALLSATF-APIYVGIVFLGFTPDHRCRSPGVAELSLRC 63
           V++  +  GE   +Q  + FLLA+L   + A   + I  +G TP +              
Sbjct: 3   VEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYH------------- 49

Query: 64  GWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCR 123
            W  AE L     G   AGE           DW             L  N S +      
Sbjct: 50  -WDLAELLPNQSHGNQSAGEDQAFG------DW------------LLTANGSEI-----H 85

Query: 124 DGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTT 183
               + +  +SI +E+ L+   S+ +    S    G F+G +S G ++DRFGRK   LT 
Sbjct: 86  KHVHFSSSFTSIASEWFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTG 145

Query: 184 VLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQV 243
             ++    +    SP+Y +  + R + G+++    L+ ++L+ E VG  Y    G    +
Sbjct: 146 FALDILFAIANGFSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGL 205

Query: 244 AYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRII 303
            + VG+   A + Y +  WR L   V L      L    IPESPRWL SQ + +EA   +
Sbjct: 206 FFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEAL 265

Query: 304 KHIAKKNGK---SLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSV 360
             IAK+N K   +   +    R   ETG     SFLDL R   +  HT+ILM+ WF  S+
Sbjct: 266 YLIAKRNRKLKCTFSLTHPANRSCRETG-----SFLDLFRYRVLLGHTLILMFIWFVCSL 320

Query: 361 LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDR--IGRRYPWAASNMVAGAAC 418
           +Y GL +  G  G +IY +   S L+E P+  + I  I++   GR+   +A   + G AC
Sbjct: 321 VYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLAC 380

Query: 419 LASVFIP--GDLQWLKII----ISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472
           L  +F+P   D     ++    +S LG++ I+ A+ IV +  +ELYPT IRN+G+  CS 
Sbjct: 381 LIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSM 440

Query: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532
              +GGII PF +  L  +   LP +VFG  GL +G L LLLPET    L ET  + +  
Sbjct: 441 FSRVGGIIAPF-IPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVY 499

Query: 533 QRPRKNKEKMIYLQVQKLD 551
              R  +E    L +Q LD
Sbjct: 500 SYRRLGEEA---LSLQALD 515


>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
           sapiens]
          Length = 506

 Score =  218 bits (556), Expect = 9e-57
 Identities = 166/561 (29%), Positives = 249/561 (44%), Gaps = 80/561 (14%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
           +D+L+  G    FQ+    L+ L     A       F    P H CR P  A LS   G 
Sbjct: 4   NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63

Query: 65  --WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGP 121
             W P +             +  P  C R+    W     +  +   +  T        P
Sbjct: 64  EVWLPRDR------------QGQPESCLRFTSPQWGLPFLNGTEANGTGATE-------P 104

Query: 122 CRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLC 179
           C DGW+Y+  T  S+IVTE++LVC++  +  L QS   VG  +G+M  GY+ADR GR+  
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

Query: 180 LLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGI 239
           L+   L  A +G   A +P +     FRL+ G+      L    L  E++    R  VG 
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224

Query: 240 FYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEA 299
                Y++G  +LAGVAYA+PHWR LQ  V+ P F F +Y W   ES RW  S  +    
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284

Query: 300 MRIIKHIAKKNGK-----SLPASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMY 353
           +R ++ +A+ NGK      L   + R  L++E T  K   S ++L+R P +R   + L  
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344

Query: 354 NWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMV 413
            WF +S  Y GL+M +   G +IYL       V+ PA  +  L I+ +GRR    A+ ++
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404

Query: 414 AGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSM 473
           AG   L +  IP D   ++  ++ LG+  +  ++  + L   ELYPT IR          
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR---------- 454

Query: 474 CDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
                                               + +LLPET G+ LP+T+++ E+  
Sbjct: 455 -----------------------------------AVTVLLPETLGQPLPDTVQDLES-- 477

Query: 534 RPRKNKEKMIYLQVQKLDIPL 554
             RK K+     + QK  +PL
Sbjct: 478 --RKGKQTRQQQEHQKYMVPL 496


>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
           sapiens]
          Length = 519

 Score =  218 bits (554), Expect = 2e-56
 Identities = 167/570 (29%), Positives = 250/570 (43%), Gaps = 85/570 (14%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
           +D+L+  G    FQ+    L+ L     A       F    P H CR P  A LS   G 
Sbjct: 4   NDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL 63

Query: 65  --WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGP 121
             W P +             +  P  C R+    W     +  +   +  T        P
Sbjct: 64  EVWLPRDR------------QGQPESCLRFTSPQWGLPFLNGTEANGTGATE-------P 104

Query: 122 CRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLC 179
           C DGW+Y+  T  S+IVTE++LVC++  +  L QS   VG  +G+M  GY+ADR GR+  
Sbjct: 105 CTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKV 164

Query: 180 LLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGI 239
           L+   L  A +G   A +P +     FRL+ G+      L    L  E++    R  VG 
Sbjct: 165 LILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGT 224

Query: 240 FYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEA 299
                Y++G  +LAGVAYA+PHWR LQ  V+ P F F +Y W   ES RW  S  +    
Sbjct: 225 LIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLT 284

Query: 300 MRIIKHIAKKNGK-----SLPASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMY 353
           +R ++ +A+ NGK      L   + R  L++E T  K   S ++L+R P +R   + L  
Sbjct: 285 LRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSM 344

Query: 354 NWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMV 413
            WF +S  Y GL+M +   G +IYL       V+ PA  +  L I+ +GRR    A+ ++
Sbjct: 345 LWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLL 404

Query: 414 AGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSM 473
           AG   L +  IP D   ++  ++ LG+  +  ++  + L   ELYPT IR          
Sbjct: 405 AGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIR---------- 454

Query: 474 CDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
                                               + +LLPET G+ LP+T+++ E+  
Sbjct: 455 -----------------------------------AVTVLLPETLGQPLPDTVQDLESRW 479

Query: 534 R---------PRKNKEKMIYLQVQKLDIPL 554
                     PRK K+     + QK  +PL
Sbjct: 480 APTQKEAGIYPRKGKQTRQQQEHQKYMVPL 509


>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
          Length = 550

 Score =  207 bits (527), Expect = 2e-53
 Identities = 151/501 (30%), Positives = 247/501 (49%), Gaps = 18/501 (3%)

Query: 42  FLGFTPDHRCRSPGVAELS-LRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQST 100
           F    P HRC +  +   S +    +P   L  ++P PGP     P QCRR+     Q  
Sbjct: 40  FSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIP-PGP--NQGPHQCRRFR----QPQ 92

Query: 101 FDCVDPLASLDTNRSRLPLGPCRDGWVYETP--GSSIVTEFNLVCANSWMLDLFQSSVNV 158
           +  +DP A+  T+ S     PC DGWVY+     S+IV +++LVC++  +  L QS    
Sbjct: 93  WQLLDPNATA-TSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMS 151

Query: 159 GFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGW 218
           G  +GS   G ++ RFGRK  L    L  A AG     +PT+      R +        +
Sbjct: 152 GILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIF 211

Query: 219 LIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLL 278
           L    L+ E+     R         A++ G   L G+A+AL  WR LQ   ++P F   L
Sbjct: 212 LSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISL 271

Query: 279 YYWCIPESPRWLISQNKNAEAMRIIKHIAKKNG----KSLPASLQRLRLEEETGKKLNP- 333
             W +PES RWLI + K  +A++ ++ +A+ NG    K+L   +    ++EE      P 
Sbjct: 272 ISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPR 331

Query: 334 SFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFM 393
           S LDL   P +R  +  ++   F+  + Y GL+  +   G +I+L       V+F     
Sbjct: 332 SVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRAT 391

Query: 394 IILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLV 453
             L +  +GRR   A S  +AG A LA++ +P DLQ L+++ + LG+    ++   + + 
Sbjct: 392 TALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIY 451

Query: 454 NAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVL- 512
            AEL+PT +R     I  ++  +G ++ P ++     + L LP +++GV+ + +  +VL 
Sbjct: 452 KAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPL-LPPLLYGVISIASSLVVLF 510

Query: 513 LLPETKGKALPETIEEAENMQ 533
            LPET+G  LP+TI++ E+ +
Sbjct: 511 FLPETQGLPLPDTIQDLESQK 531


>gi|148664184 solute carrier family 22, member 10 [Homo sapiens]
          Length = 541

 Score =  207 bits (527), Expect = 2e-53
 Identities = 137/465 (29%), Positives = 233/465 (50%), Gaps = 20/465 (4%)

Query: 86  PRQCRRY-EVDWNQSTFD-CVDPLASLDTNRSRLPLGPCRDGWVYETP--GSSIVTEFNL 141
           P +CRR+    W     +  +   +  DT        PC DGWVY+     S+IVT+++L
Sbjct: 85  PEKCRRFVHPQWQLLHLNGTIHSTSEADTE-------PCVDGWVYDQSYFPSTIVTKWDL 137

Query: 142 VCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYT 201
           VC    +  + Q  +  G  +G +  G+++DRFGR+  L   +L  A      A +PT+ 
Sbjct: 138 VCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLAITDTCAAFAPTFP 197

Query: 202 WMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPH 261
              + R + G  S        + ITE++    +  V I    A ++G ++L G+AY    
Sbjct: 198 VYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGALSIGQIILGGLAYVFRD 257

Query: 262 WRWLQFTVALPNF-FFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNG-----KSLP 315
           W+ L    ++P F FFLL  W + ES RWLI  NK  E ++ ++ +A+ NG     ++L 
Sbjct: 258 WQTLHVVASVPFFVFFLLSRWLV-ESARWLIITNKLDEGLKALRKVARTNGIKNAEETLN 316

Query: 316 ASLQRLRLEEE-TGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGD 374
             + R  ++EE    +   +  DL R P +RK   IL++  F +++ + G ++++   G 
Sbjct: 317 IEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFANTIPFYGTMVNLQHVGS 376

Query: 375 NIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKII 434
           NI+L       V      + +LT++ +GRR        + G + LA+ F+P ++Q L++ 
Sbjct: 377 NIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTFVPKEMQTLRVA 436

Query: 435 ISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLE 494
           ++CLG       +  V +   EL PT +R     I  +   IG  + P L+  LT  +  
Sbjct: 437 LACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGAALAPLLM-TLTVFFTT 495

Query: 495 LPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNK 539
           LP +++G+  ++ G +V LLPETK   LP+TI++ EN ++  K K
Sbjct: 496 LPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK 540


>gi|211059435 solute carrier family 22, member 24 [Homo sapiens]
          Length = 551

 Score =  205 bits (521), Expect = 1e-52
 Identities = 154/555 (27%), Positives = 259/555 (46%), Gaps = 23/555 (4%)

Query: 6   DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCG- 64
           D +L+  G    FQ  +     + +    P  V   F  FTP HRC  P +   ++    
Sbjct: 4   DVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDND 63

Query: 65  ---WSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLG 120
               S  + L  ++P         P++C+R+    W     +   P      N +     
Sbjct: 64  TGTLSKDDLLRISIPLDS---NLRPQKCQRFIHPQWQLLHLNGTFP------NTNEPDTE 114

Query: 121 PCRDGWVYETPG--SSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKL 178
           PC DGWVY+     S+IVTE++LVC +  +  + QS    G  +G +  G+++DR GRK+
Sbjct: 115 PCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKI 174

Query: 179 CLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVG 238
                 L  A +    A +PT+    I R + G  +       +IL  E+   R R    
Sbjct: 175 ICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTI 234

Query: 239 IFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAE 298
           +    +Y+VG ++L G+A+A+  W  LQ TV+ P     L  W + ES RWLI  N+  E
Sbjct: 235 MVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDE 294

Query: 299 AMRIIKHIAKKNGK-----SLPASLQRLRLEEETGK-KLNPSFLDLVRTPQIRKHTMILM 352
            ++ ++ +A  NGK     +L   L R  +++E    ++  S   L R P++R     L 
Sbjct: 295 GLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLC 354

Query: 353 YNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNM 412
           +  F  +V + GLI+++   G N+ L       V F A  + +LT++ +GRR        
Sbjct: 355 FVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTF 414

Query: 413 VAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSS 472
             G   L + F+P ++Q L+++++ LG   ++ A     + + EL PT +R+    I + 
Sbjct: 415 PVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAV 474

Query: 473 MCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENM 532
               G  + P L+  L      LP + +GV  ++A  ++LLLPET+   LP TI++ EN 
Sbjct: 475 SGRTGAALAPLLM-TLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENE 533

Query: 533 QRPRKNKEKMIYLQV 547
           +  R  K++   ++V
Sbjct: 534 KDSRNIKQEDTCMKV 548


>gi|157426885 organic cation transporter like 4 [Homo sapiens]
          Length = 594

 Score =  188 bits (477), Expect = 1e-47
 Identities = 155/552 (28%), Positives = 258/552 (46%), Gaps = 42/552 (7%)

Query: 7   DVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWS 66
           ++L+  GEF  FQ+++  L  + S   A       F+       C +  +  L++    S
Sbjct: 54  NLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSWI--LAVGPHLS 111

Query: 67  PAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDG 125
            AE+LN T+P    A   S   C  Y  V WN    D +      DT+        C+DG
Sbjct: 112 KAEQLNLTIP---QAPNGSFLTCFMYLPVPWN---LDSIIQFGLNDTDT-------CQDG 158

Query: 126 WVY-ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTV 184
           W+Y +    S++ EF+LVC      D  Q     G  IGS+    I D+ GR   +L ++
Sbjct: 159 WIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSL 218

Query: 185 LINAAAGVLMAISPTYTWMLIFRLIQGLV-SKAGWLIGYI-LITEFVGRRYRRTVGIFYQ 242
           L     G   A   ++   L FR   G+  S  G+ I  I L TE++   +R    I   
Sbjct: 219 LGLIIFGFGTAFMNSFHLYLFFRF--GISQSVVGYAISSISLATEWLVGEHRAHAIILGH 276

Query: 243 VAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRI 302
             + VG ++L G+AY+LPHW+ L     +    F+ Y W +PESPRWL+ + K  EA ++
Sbjct: 277 CFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQV 336

Query: 303 IKHIAKKNGKSLPAS-LQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVL 361
           + + A  N K++P++ L  L+L  +  K    S LD  +  Q+ K T+++   WFT S  
Sbjct: 337 LCYAASVNKKTIPSNLLDELQLPRK--KVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYT 394

Query: 362 YQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLAS 421
           Y  L + M   G +++      +++E PA    I  + +IGR++  A + + A   CL  
Sbjct: 395 YFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLL 454

Query: 422 VFIP---------------GDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLG 466
           +F+P                +L+ + I++  L    +     +  L  AEL PT +R  G
Sbjct: 455 LFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATG 514

Query: 467 VHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETI 526
           + + S     G I++  ++ +  ++   LP+ +  VL +VA  L  LLPET+ + L E++
Sbjct: 515 LGLVSLASVAGAILSLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPLSESL 571

Query: 527 EEAENMQRPRKN 538
             +  ++   K+
Sbjct: 572 NHSSQIRNKVKD 583


>gi|42542386 solute carrier family 22 (organic anion/cation
           transporter), member 9 [Homo sapiens]
          Length = 553

 Score =  187 bits (475), Expect = 2e-47
 Identities = 148/552 (26%), Positives = 255/552 (46%), Gaps = 29/552 (5%)

Query: 7   DVLEHGGEFHFFQ-KQMFFLLALLSATFAPIYVGIVFLGFTPDHRC-----RSPGVAELS 60
           D+L H G+   FQ  Q  FL     AT+    +   F  F P HRC      +  V++  
Sbjct: 5   DLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLEN-FTAFIPGHRCWVHILDNDTVSDND 63

Query: 61  LRCGWSPAEELNYTVPGPGPAGEASPRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPL 119
                S    L  ++P         P +CRR+    W     +   P      N S   +
Sbjct: 64  TGA-LSQDALLRISIPLDS---NMRPEKCRRFVHPQWQLLHLNGTFP------NTSDADM 113

Query: 120 GPCRDGWVYE--TPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRK 177
            PC DGWVY+  +  S+IVTE++LVC +  +  + +     G  +G +  G+++DRFGR+
Sbjct: 114 EPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRR 173

Query: 178 LCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTV 237
             L    L  A  G   A++PT+      R + G+ + +      +LI E+   R++   
Sbjct: 174 FVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMG 233

Query: 238 GIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNA 297
                    +  + LAG+A+A+  W  LQ  V++P F   L    + ES RWLI  NK  
Sbjct: 234 ITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPE 293

Query: 298 EAMRIIKHIAKKNGK-------SLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMI 350
           E ++ ++  A ++G        +L      ++ E E  +K  PS  +++  P I K   +
Sbjct: 294 EGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISL 353

Query: 351 LMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAAS 410
           L +  F + + Y GL +H+   G+N++L       V   A  +    +  + RR      
Sbjct: 354 LSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLL 413

Query: 411 NMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHIC 470
             +     LA +F+P ++Q L+ +++ LG     +A  +      E+ PT IR   + I 
Sbjct: 414 MFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGIN 473

Query: 471 SSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530
           ++  +I G + P ++  L+     LP +++GV   ++G   LLLPET+ K L +TI++ +
Sbjct: 474 ATFANIAGALAPLMMI-LSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEK 532

Query: 531 NMQR-PRKNKEK 541
           N ++ PR+ K++
Sbjct: 533 NERKDPREPKQE 544


>gi|153791484 putative UST1-like organic anion transporter [Homo
           sapiens]
          Length = 547

 Score =  173 bits (439), Expect = 3e-43
 Identities = 120/455 (26%), Positives = 214/455 (47%), Gaps = 16/455 (3%)

Query: 86  PRQCRRY-EVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPG--SSIVTEFNLV 142
           P +CRR+    W     +   P      N S     PC DGWVY+     S+IVT+++LV
Sbjct: 85  PEKCRRFVHPQWKLIHLNGTFP------NTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLV 138

Query: 143 CANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTW 202
           C +  +  + +     G  +G    G+++DRFGRK  L  + L  A  G   A +PT   
Sbjct: 139 CESQPLNSVAKFLFMAGMMVGGNLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILV 198

Query: 203 MLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHW 262
               R + G  + +  +   +LI E++  ++          A ++G + L  +A+ +   
Sbjct: 199 YCSLRFLAGAATFSIIVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQ 258

Query: 263 RWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLR 322
             LQ  ++ P F F L+   + ES RWLI  NK  E ++ ++  A +NG      +  + 
Sbjct: 259 CILQLVMSAPCFVFFLFSRWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTME 318

Query: 323 LEEETGK------KLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNI 376
           + + T K      +   S  +L+R P I K    L +  F S++ + GL +H+   G+N+
Sbjct: 319 VLKSTMKQELEAAQKKHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNV 378

Query: 377 YLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIIS 436
           +L       V   A  +    ++ + RR        +     LA +F+P ++Q L+++++
Sbjct: 379 FLLQTLFGAVTLLANCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLA 438

Query: 437 CLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELP 496
            LG    ++          EL P+ IR     I  +  +IGG +   ++  L+     LP
Sbjct: 439 TLGVGAASLGITCSTAQENELIPSIIRGRATGITGNFANIGGALASLMMI-LSIYSRPLP 497

Query: 497 LMVFGVLGLVAGGLVLLLPETKGKALPETIEEAEN 531
            +++GV  +++G +VLLLPET+ + L ++I++ EN
Sbjct: 498 WIIYGVFAILSGLVVLLLPETRNQPLLDSIQDVEN 532


>gi|24308167 SV2 related protein [Homo sapiens]
          Length = 548

 Score =  152 bits (385), Expect = 6e-37
 Identities = 121/416 (29%), Positives = 193/416 (46%), Gaps = 50/416 (12%)

Query: 146 SWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLI 205
           SW + L  S V VG    S   G I+D++GRK  L  +VL     G+L A +P Y+W+L+
Sbjct: 119 SWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILV 178

Query: 206 FRLIQGLVSKAGWLIGYI-----LITEFVGRRYRRTVGIFYQVAYTVGLL---VLAGVAY 257
            R   GLV   G+ IG +     L  EF+  + R    +  +V + +G +   VLA    
Sbjct: 179 LR---GLV---GFGIGGVPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVM 232

Query: 258 ALPHWRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPAS 317
               WRWL    A+P   F +  + +PES R+ +      +A+  +K IA +NG  +P  
Sbjct: 233 PSLGWRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLG 292

Query: 318 LQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIM---HMGLAGD 374
              +  +E+ GK  +      + TP  R  T++L + WF+++  Y GL++    +  AGD
Sbjct: 293 KLIISRQEDRGKMRD------LFTPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELFQAGD 346

Query: 375 ------------------------NIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAAS 410
                                     Y+D  ++ L EFP   + +  IDR+GR+   A  
Sbjct: 347 VCGISSRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALC 406

Query: 411 NMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHIC 470
             V  + C   +FI      L +++  + R  I+  ++   +   E+YPT  R LG+  C
Sbjct: 407 -FVIFSFCSLLLFICVGRNVLTLLLF-IARAFISGGFQAAYVYTPEVYPTATRALGLGTC 464

Query: 471 SSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLP-ETKGKALPET 525
           S M  +G +ITPF+   +    + L L V+    L+A      LP ETKG+ L E+
Sbjct: 465 SGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETKGRGLQES 520


>gi|24497487 urate anion exchanger 1 isoform b [Homo sapiens]
          Length = 332

 Score =  146 bits (368), Expect = 6e-35
 Identities = 95/314 (30%), Positives = 159/314 (50%), Gaps = 13/314 (4%)

Query: 227 EFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYWCIPES 286
           E+   R R  V     + ++ G  + A VAY +  W  LQ  V++P F   LY W + ES
Sbjct: 2   EWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAES 61

Query: 287 PRWLISQNKNAEAMRIIKHIAKKNGK-----SLPASLQRLRLEEETGKKLNPSFLD-LVR 340
            RWL++  +    ++ +  +A  NGK     +L   +    + EE      P+ L  L+R
Sbjct: 62  ARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLR 121

Query: 341 TPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDR 400
            P +R  T I    WF     + GL + +   G NI+L   +  +V+ PA    +L +  
Sbjct: 122 MPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSH 181

Query: 401 IGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPT 460
           +GRR   AAS ++AG   LA+  +P ++  L+  ++ LG  G+  A+  + + ++EL+PT
Sbjct: 182 LGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 241

Query: 461 FIRNLGVHICSSMCDIGGIITPFLVYRLTNI---WLELPLMVFGVLGLVAGGLVLLLPET 517
            +R   V +       G I+ P +  RL  +   W  LPL+V+G + +++G   LLLPET
Sbjct: 242 VLRMTAVGLGQMAARGGAILGPLV--RLLGVHGPW--LPLLVYGTVPVLSGLAALLLPET 297

Query: 518 KGKALPETIEEAEN 531
           +   LP+TI++ +N
Sbjct: 298 QSLPLPDTIQDVQN 311


>gi|239751156 PREDICTED: hypothetical protein LOC146429 isoform 6
           [Homo sapiens]
          Length = 560

 Score =  144 bits (363), Expect = 2e-34
 Identities = 140/535 (26%), Positives = 239/535 (44%), Gaps = 54/535 (10%)

Query: 28  LLSATFAP-IYVGIVF-----LGFTPDHRCR-SPGVAELSLRCGWSPAEELNYTVPGPGP 80
           L SA++ P I +G+V      L   P   CR  P +   +LR    PA  L+  +P  GP
Sbjct: 21  LASASWVPCIVLGLVLSSEELLTAQPAPHCRPDPTLLPPALRALRGPAL-LDAAIPRLGP 79

Query: 81  AGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNR-SRLPLGPCRDGWVYETPGSSIVTEF 139
              ASP                C+ PL  L  +  + L   P    W     G++    +
Sbjct: 80  TRAASP----------------CL-PLGVLSPSYLAPLTRAPRPSSWA-SCSGAAAGPTW 121

Query: 140 NLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPT 199
           NLVC + W + L Q S  +G+ +G + +G   DRFGR+   + ++++    G   A++ +
Sbjct: 122 NLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAAS 181

Query: 200 YTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYAL 259
           +  +L+ RL+ G       L  Y+   E     +R    +   +   VG L+L G+A  +
Sbjct: 182 FPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALV 241

Query: 260 PHWRWLQFTVALPNFFFLLYYW---CIPESPRWLISQNKNAEAMRIIKHIAKKNG----- 311
             WR LQ   AL +   LL++      PESP WL++  + A A +I+   A+ +G     
Sbjct: 242 QDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGD 301

Query: 312 -----KSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLI 366
                 SL  + +   L   + +    S L L+RT    ++ +IL ++      +     
Sbjct: 302 SSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVGGGIRASFR 361

Query: 367 MHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACL----ASV 422
             +       YL +F  A +E  A   ++LT D  GRR       MV G A L     + 
Sbjct: 362 RSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQ 421

Query: 423 FIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIG---GI 479
           ++PG   W  + +S LG +       +  L  AE++PT IR  G+ +      +G   G+
Sbjct: 422 YLPG---WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGL 478

Query: 480 ITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQR 534
           +    ++     +L+   +VF  L ++A   VLLLPE++ + LP+++++A+ ++R
Sbjct: 479 LD--TLHGRQGFFLQ--QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLRR 529


>gi|239745643 PREDICTED: hypothetical protein LOC146429 isoform 1
           [Homo sapiens]
          Length = 558

 Score =  141 bits (356), Expect = 1e-33
 Identities = 110/421 (26%), Positives = 196/421 (46%), Gaps = 23/421 (5%)

Query: 132 GSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAG 191
           G++    +NLVC + W + L Q S  +G+ +G + +G   DRFGR+   + ++++    G
Sbjct: 112 GAAAGPTWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLG 171

Query: 192 VLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLV 251
              A++ ++  +L+ RL+ G       L  Y+   E     +R    +   +   VG L+
Sbjct: 172 ASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLL 231

Query: 252 LAGVAYALPHWRWLQFTVALPNFFFLLYYW---CIPESPRWLISQNKNAEAMRIIKHIAK 308
           L G+A  +  WR LQ   AL +   LL++      PESP WL++  + A A +I+   A+
Sbjct: 232 LPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAE 291

Query: 309 KNG----------KSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTS 358
            +G           SL  + +   L   + +    S L L+RT    ++ +IL ++    
Sbjct: 292 ASGVGPGDSSLEENSLATATELTMLSARSPQPRYHSPLGLLRTRVTWRNGLILGFSSLVG 351

Query: 359 SVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAAC 418
             +       +       YL +F  A +E  A   ++LT D  GRR       MV G A 
Sbjct: 352 GGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLAS 411

Query: 419 L----ASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMC 474
           L     + ++PG   W  + +S LG +       +  L  AE++PT IR  G+ +     
Sbjct: 412 LLLLAGAQYLPG---WTVLFLSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAG 468

Query: 475 DIGGIITPF-LVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQ 533
            +G    P   ++     +L+   +VF  L ++A   VLLLPE++ + LP+++++A+ ++
Sbjct: 469 FLGQAAGPLDTLHGRQGFFLQ--QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADRLR 526

Query: 534 R 534
           R
Sbjct: 527 R 527


>gi|63999576 solute carrier family 22, member 17 isoform b [Homo
           sapiens]
          Length = 520

 Score =  124 bits (310), Expect = 3e-28
 Identities = 117/433 (27%), Positives = 193/433 (44%), Gaps = 25/433 (5%)

Query: 122 CRDGWVYETPGSSIVT-----EFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGR 176
           C   W Y   G  ++T     +++LVC   W + L Q    +GF  G + +GY ADRFGR
Sbjct: 70  CLKDWDYN--GLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGR 127

Query: 177 KLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRT 236
           +  +L T+ +    GV  A + + T ++  R + G +     L  Y++  E      R  
Sbjct: 128 RGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLR 187

Query: 237 VGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVALPNFFFLLYYW--CIPESPRWLISQN 294
           V +  ++    G  +  G+A     WR+LQ  +  P   FL Y W     ES RWLI + 
Sbjct: 188 VALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKR 247

Query: 295 KNAEAMRIIKHIAKKN-------GKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKH 347
           +  EA  +++ +A++N       G+    +LQ L          + SF  L+    I K+
Sbjct: 248 QIEEAQSVLRILAERNRPHGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKN 307

Query: 348 TMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFM----IILTIDRIGR 403
            +IL    FT+ + +     +  + G     DF+  +L+    A +    + +T+DR GR
Sbjct: 308 LLIL---GFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGR 364

Query: 404 RYPWAASNMVAGAACLASVFIPGDLQWLKI-IISCLGRMGITMAYEIVCLVNAELYPTFI 462
           R     S  + G A L  + +   L    I   S LG      A  +  L+ AE+ PT +
Sbjct: 365 RGILLLSMTLTGIASLVLLGLWDYLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTV 424

Query: 463 RNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKAL 522
           R  G+ +  ++  +GG+  P     + +    L  +V     L+    ++LLPETK K L
Sbjct: 425 RGRGLGLIMALGALGGLSGPAQRLHMGH-GAFLQHVVLAACALLCILSIMLLPETKRKLL 483

Query: 523 PETIEEAENMQRP 535
           PE + + E  +RP
Sbjct: 484 PEVLRDGELCRRP 496


>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
          Length = 492

 Score =  119 bits (298), Expect = 7e-27
 Identities = 110/427 (25%), Positives = 181/427 (42%), Gaps = 67/427 (15%)

Query: 146 SWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLI 205
           +W + L  + V  G+ + S+  G +ADR+GR   LL + L  A   +L + +P+Y W + 
Sbjct: 83  NWQVALVTTMVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVF 142

Query: 206 FRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYAL---PHW 262
            R + G    +G   G I+ TEF+  +YR  +    QV +  G L++ G+A  +     W
Sbjct: 143 LRTMVG-CGVSGHSQGLIIKTEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGW 201

Query: 263 RWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLR 322
           RWL    ++P    ++ +  IPES R+ +S      A+  ++ +AK N   +P       
Sbjct: 202 RWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEP 261

Query: 323 LEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIM--------------- 367
           + E+ G+     F DL+    +R  T+ +   W   S  Y G+I+               
Sbjct: 262 VLEKRGR-----FADLLDAKYLRT-TLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 315

Query: 368 ---------------------HMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYP 406
                                HM    D  Y     S + E     + IL I+ +GRR  
Sbjct: 316 SDSAVVVTGGDSGESQSPCYCHMFAPSD--YRTMIISTIGEIALNPLNILGINFLGRRL- 372

Query: 407 WAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMG--------ITMAYEIVCLVNAELY 458
               ++     C A  F+      L I  S  G +G        +   +  V +  AE+Y
Sbjct: 373 ----SLSITMGCTALFFL-----LLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVY 423

Query: 459 PTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLP-ET 517
           PT +R LG+    S+C IG ++ PF+   L +  +   L +F  + +V       LP ET
Sbjct: 424 PTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPIET 483

Query: 518 KGKALPE 524
           KG+AL +
Sbjct: 484 KGRALQQ 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.142    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,547,730
Number of Sequences: 37866
Number of extensions: 988656
Number of successful extensions: 3435
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 3191
Number of HSP's gapped (non-prelim): 132
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.