Search of human proteins with 4506181

Search of human proteins with 4506181

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
         (234 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]             468   e-132
gi|4506189 proteasome alpha 7 subunit [Homo sapiens]                  160   9e-40
gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]       159   3e-39
gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]       152   2e-37
gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]      144   5e-35
gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]        144   5e-35
gi|23110944 proteasome alpha 6 subunit [Homo sapiens]                 134   5e-32
gi|23110942 proteasome alpha 5 subunit [Homo sapiens]                 133   1e-31
gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]        121   6e-28
gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]       120   8e-28
gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]       114   6e-26
gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]        111   5e-25
gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]       110   1e-24
gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]      106   1e-23
gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]       65   5e-11
gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Hom...    50   1e-06
gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo...    50   1e-06
gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]          49   4e-06
gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]             48   6e-06
gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]             48   6e-06
gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]             48   6e-06
gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]        42   6e-04
gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]        36   0.025
gi|153791216 proteasome beta 11 subunit [Homo sapiens]                 34   0.095
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          31   1.0  
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]           30   1.8  
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]            30   1.8  
gi|22748615 hypothetical protein LOC90488 [Homo sapiens]               30   1.8  
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]     30   2.3  
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]     30   2.3  

>gi|4506181 proteasome subunit alpha type 2 [Homo sapiens]
          Length = 234

 Score =  468 bits (1204), Expect = e-132
 Identities = 234/234 (100%), Positives = 234/234 (100%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
Sbjct: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60

Query: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120
           SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
Sbjct: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120

Query: 121 YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180
           YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
Sbjct: 121 YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180

Query: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA 234
           DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
Sbjct: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA 234


>gi|4506189 proteasome alpha 7 subunit [Homo sapiens]
          Length = 248

 Score =  160 bits (405), Expect = 9e-40
 Identities = 89/235 (37%), Positives = 140/235 (59%), Gaps = 12/235 (5%)

Query: 6   YSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKV 65
           Y  ++T FSP G L Q+EYA  AV  G+ +VG++  + VVL  EKK  + L DER+V K+
Sbjct: 3   YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVRKI 62

Query: 66  EPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSG 125
             +  ++ + ++G+  D R++++RAR   Q + L  ++P+    + + +AS+ Q YTQS 
Sbjct: 63  CALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQSN 122

Query: 126 GVRPFGVSLLICGWN-EGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLEL 184
           G RPFG+S LI G++ +G P L+Q+DPSG Y AWKA A+G+   + + FLEK Y      
Sbjct: 123 GRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYT----- 177

Query: 185 EDAIHTAILTLKESFEG-----QMTEDNIEVGIC-NEAGFRRLTPTEVKDYLAAI 233
           ++AI T  LT+K   +      Q    NIE+ +   +   + L P E++ Y+A I
Sbjct: 178 DEAIETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEI 232


>gi|68303563 proteasome alpha 8 subunit isoform 2 [Homo sapiens]
          Length = 250

 Score =  159 bits (401), Expect = 3e-39
 Identities = 96/237 (40%), Positives = 139/237 (58%), Gaps = 7/237 (2%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           MA R Y  ++T FSP G L Q+EYA  AV  G+ +VGI+  N VVL  EKK  + L DER
Sbjct: 1   MASR-YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDER 59

Query: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120
           +V K+  +  H+ + ++G+  D RV+++RAR   Q + L  ++P+    + + +A++ Q+
Sbjct: 60  TVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQK 119

Query: 121 YTQSGGVRPFGVSLLICGW-NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYN 179
           YTQS G RPFG+S LI G+ ++G   L+Q+DPSG Y AWKA A+G++    + FLEK Y 
Sbjct: 120 YTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYT 179

Query: 180 EDLELED--AIHTAILTLKESFEGQMTEDNIEVGIC-NEAGFRRLTPTEVKDYLAAI 233
           ED    D  AI  AI  L E    Q    NIE+ I       +  +  EV+ Y+  I
Sbjct: 180 EDAIASDSEAIKLAIKALLEVV--QSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 234


>gi|68303561 proteasome alpha 8 subunit isoform 1 [Homo sapiens]
          Length = 256

 Score =  152 bits (384), Expect = 2e-37
 Identities = 96/243 (39%), Positives = 139/243 (57%), Gaps = 13/243 (5%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           MA R Y  ++T FSP G L Q+EYA  AV  G+ +VGI+  N VVL  EKK  + L DER
Sbjct: 1   MASR-YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDER 59

Query: 61  SVHKVEPITKHIGL------VYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRV 114
           +V K+  +  H+ +      ++ G+  D RV+++RAR   Q + L  ++P+    + + +
Sbjct: 60  TVRKICALDDHVCMAFAVLTIFIGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFI 119

Query: 115 ASVMQEYTQSGGVRPFGVSLLICGW-NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTF 173
           A++ Q+YTQS G RPFG+S LI G+ ++G   L+Q+DPSG Y AWKA A+G++    + F
Sbjct: 120 ATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREF 179

Query: 174 LEKRYNEDLELED--AIHTAILTLKESFEGQMTEDNIEVGIC-NEAGFRRLTPTEVKDYL 230
           LEK Y ED    D  AI  AI  L E    Q    NIE+ I       +  +  EV+ Y+
Sbjct: 180 LEKNYTEDAIASDSEAIKLAIKALLEVV--QSGGKNIELAIIRRNQPLKMFSAKEVELYV 237

Query: 231 AAI 233
             I
Sbjct: 238 TEI 240


>gi|156713442 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
          Length = 261

 Score =  144 bits (364), Expect = 5e-35
 Identities = 82/211 (38%), Positives = 123/211 (58%), Gaps = 4/211 (1%)

Query: 4   RGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSV- 62
           R Y    T FSP G+L Q+EYA+ A+      +GI A +GV+LA E++    L DE    
Sbjct: 3   RRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFS 62

Query: 63  HKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYT 122
            K+  + + +    +G+  D  VL +  R +AQ+Y L YQEPIP  QLV  +  + Q YT
Sbjct: 63  EKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYT 122

Query: 123 QSGGVRPFGVSLLICGWNEGRPY-LFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE- 180
           Q GG RPFGVSLL  GW++   + L+QSDPSG Y  WKAT +G N     + L++ Y E 
Sbjct: 123 QFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEG 182

Query: 181 DLELEDAIHTAILTLKESFE-GQMTEDNIEV 210
           ++ L+ A+  AI  L ++ +  +++ + +E+
Sbjct: 183 EMTLKSALALAIKVLNKTMDVSKLSAEKVEI 213


>gi|4506185 proteasome alpha 4 subunit isoform 1 [Homo sapiens]
          Length = 261

 Score =  144 bits (364), Expect = 5e-35
 Identities = 82/211 (38%), Positives = 123/211 (58%), Gaps = 4/211 (1%)

Query: 4   RGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSV- 62
           R Y    T FSP G+L Q+EYA+ A+      +GI A +GV+LA E++    L DE    
Sbjct: 3   RRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFS 62

Query: 63  HKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYT 122
            K+  + + +    +G+  D  VL +  R +AQ+Y L YQEPIP  QLV  +  + Q YT
Sbjct: 63  EKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYT 122

Query: 123 QSGGVRPFGVSLLICGWNEGRPY-LFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE- 180
           Q GG RPFGVSLL  GW++   + L+QSDPSG Y  WKAT +G N     + L++ Y E 
Sbjct: 123 QFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEG 182

Query: 181 DLELEDAIHTAILTLKESFE-GQMTEDNIEV 210
           ++ L+ A+  AI  L ++ +  +++ + +E+
Sbjct: 183 EMTLKSALALAIKVLNKTMDVSKLSAEKVEI 213


>gi|23110944 proteasome alpha 6 subunit [Homo sapiens]
          Length = 246

 Score =  134 bits (338), Expect = 5e-32
 Identities = 84/236 (35%), Positives = 123/236 (52%), Gaps = 6/236 (2%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAV-AGGAPSVGIKAANGVVLATEKKQKSILYDERSVH 63
           G+   +T FSP G+L Q+EYA  A+  GG  SV ++  +  V+ T+KK    L D  +V 
Sbjct: 8   GFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVT 67

Query: 64  KVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQ 123
            +  IT++IG V +GM  D R  V RAR  A  +   Y   IP   L +R+A + Q YTQ
Sbjct: 68  HLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQ 127

Query: 124 SGGVRPFGVSLLICGWNEGR-PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE-- 180
           +  +RP G  +++ G +E + P +++ DP+G Y  +KATA G       +FLEK+  +  
Sbjct: 128 NAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKF 187

Query: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGI--CNEAGFRRLTPTEVKDYLAAIA 234
           D   E  + TAI  L            IEVG+       FR LT  E+  +L A+A
Sbjct: 188 DWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALA 243


>gi|23110942 proteasome alpha 5 subunit [Homo sapiens]
          Length = 241

 Score =  133 bits (334), Expect = 1e-31
 Identities = 74/234 (31%), Positives = 127/234 (54%), Gaps = 6/234 (2%)

Query: 6   YSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKV 65
           Y   + TFSP G+L Q+EYA+ A+  G+ ++GI+ + GV LA EK+  S L +  S+ K+
Sbjct: 8   YDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLMEPSSIEKI 67

Query: 66  EPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSG 125
             I  HIG   SG+  D + L+ +AR   Q ++  Y E +    + Q V+++  ++ +  
Sbjct: 68  VEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLALQFGEED 127

Query: 126 G-----VRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180
                  RPFGV+LL  G +E  P LF  DPSG +    A A+G      ++ L++ Y++
Sbjct: 128 ADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSSLQEVYHK 187

Query: 181 DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEA-GFRRLTPTEVKDYLAAI 233
            + L++AI ++++ LK+  E ++   NIE+        F   T  E+++ +  I
Sbjct: 188 SMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKDI 241


>gi|4506179 proteasome alpha 1 subunit isoform 2 [Homo sapiens]
          Length = 263

 Score =  121 bits (303), Expect = 6e-28
 Identities = 71/216 (32%), Positives = 120/216 (55%), Gaps = 6/216 (2%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           M    Y   +T +SP G++ QIEYA+ AV  G+ +VG+K+    VL   K+ +S L   +
Sbjct: 1   MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60

Query: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120
              K+  +  HIG+  +G+  D R+L +  R+       V+  P+P ++LV  + S  Q 
Sbjct: 61  K--KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQI 118

Query: 121 YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE 180
            TQ  G RP+GV LLI G+++  P++FQ+ PS  YF  +A ++G    + +T+LE+  +E
Sbjct: 119 PTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSE 178

Query: 181 DLE--LEDAIHTAILTLKESF--EGQMTEDNIEVGI 212
            +E  L + +   +  L+E+   E  +T  N+ +GI
Sbjct: 179 FMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGI 214


>gi|23110935 proteasome alpha 1 subunit isoform 1 [Homo sapiens]
          Length = 269

 Score =  120 bits (302), Expect = 8e-28
 Identities = 70/211 (33%), Positives = 119/211 (56%), Gaps = 6/211 (2%)

Query: 6   YSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKV 65
           Y   +T +SP G++ QIEYA+ AV  G+ +VG+K+    VL   K+ +S L   +   K+
Sbjct: 12  YDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQK--KI 69

Query: 66  EPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSG 125
             +  HIG+  +G+  D R+L +  R+       V+  P+P ++LV  + S  Q  TQ  
Sbjct: 70  LHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRY 129

Query: 126 GVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLE-- 183
           G RP+GV LLI G+++  P++FQ+ PS  YF  +A ++G    + +T+LE+  +E +E  
Sbjct: 130 GRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECN 189

Query: 184 LEDAIHTAILTLKESF--EGQMTEDNIEVGI 212
           L + +   +  L+E+   E  +T  N+ +GI
Sbjct: 190 LNELVKHGLRALRETLPAEQDLTTKNVSIGI 220


>gi|68303565 proteasome alpha 8 subunit isoform 3 [Homo sapiens]
          Length = 212

 Score =  114 bits (286), Expect = 6e-26
 Identities = 82/237 (34%), Positives = 117/237 (49%), Gaps = 45/237 (18%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           MA R Y  ++T FSP G L Q+EYA  AV  G+ +VGI+                     
Sbjct: 1   MASR-YDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIR--------------------- 38

Query: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE 120
                            G+  D RV+++RAR   Q + L  ++P+    + + +A++ Q+
Sbjct: 39  -----------------GLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQK 81

Query: 121 YTQSGGVRPFGVSLLICGW-NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYN 179
           YTQS G RPFG+S LI G+ ++G   L+Q+DPSG Y AWKA A+G++    + FLEK Y 
Sbjct: 82  YTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYT 141

Query: 180 EDLELED--AIHTAILTLKESFEGQMTEDNIEVGIC-NEAGFRRLTPTEVKDYLAAI 233
           ED    D  AI  AI  L E    Q    NIE+ I       +  +  EV+ Y+  I
Sbjct: 142 EDAIASDSEAIKLAIKALLEVV--QSGGKNIELAIIRRNQPLKMFSAKEVELYVTEI 196


>gi|4506183 proteasome alpha 3 subunit isoform 1 [Homo sapiens]
          Length = 255

 Score =  111 bits (278), Expect = 5e-25
 Identities = 64/186 (34%), Positives = 100/186 (53%), Gaps = 3/186 (1%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHK 64
           GY  S +TFSP G++ Q+EYA+ AV   + ++GI+  +GVV   EK   S LY+E S  +
Sbjct: 7   GYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKR 66

Query: 65  VEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQS 124
           +  + +H+G+  +G+  D R L   AR+ A  +   +   IP   L  RVA  +  YT  
Sbjct: 67  LFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLY 126

Query: 125 GGVRPFGVSLLICGW--NEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDL 182
             VRPFG S ++  +  N+G   L+  DPSG  + +   A+GK     KT +EK   +++
Sbjct: 127 SAVRPFGCSFMLGSYSVNDG-AQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEM 185

Query: 183 ELEDAI 188
              D +
Sbjct: 186 TCRDIV 191


>gi|23110939 proteasome alpha 3 subunit isoform 2 [Homo sapiens]
          Length = 248

 Score =  110 bits (275), Expect = 1e-24
 Identities = 64/184 (34%), Positives = 97/184 (52%), Gaps = 6/184 (3%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHK 64
           GY  S +TFSP G++ Q+EYA+ AV   + ++GI+  +GVV   EK   S LY+E S  +
Sbjct: 7   GYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKR 66

Query: 65  VEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQS 124
           +  + +H+G+  +G+  D R L   AR+ A  +   +   IP   L  RVA  +  YT  
Sbjct: 67  LFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLY 126

Query: 125 GGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLEL 184
             VRPFG     C  N+G   L+  DPSG  + +   A+GK     KT +EK   +++  
Sbjct: 127 SAVRPFG-----CSVNDG-AQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTC 180

Query: 185 EDAI 188
            D +
Sbjct: 181 RDIV 184


>gi|156713444 proteasome alpha 4 subunit isoform 2 [Homo sapiens]
          Length = 190

 Score =  106 bits (265), Expect = 1e-23
 Identities = 57/137 (41%), Positives = 85/137 (62%), Gaps = 3/137 (2%)

Query: 77  SGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLI 136
           +G+  D  VL +  R +AQ+Y L YQEPIP  QLV  +  + Q YTQ GG RPFGVSLL 
Sbjct: 6   AGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLY 65

Query: 137 CGWNEGRPY-LFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE-DLELEDAIHTAILT 194
            GW++   + L+QSDPSG Y  WKAT +G N     + L++ Y E ++ L+ A+  AI  
Sbjct: 66  IGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKV 125

Query: 195 LKESFE-GQMTEDNIEV 210
           L ++ +  +++ + +E+
Sbjct: 126 LNKTMDVSKLSAEKVEI 142


>gi|221316716 proteasome alpha 1 subunit isoform 3 [Homo sapiens]
          Length = 130

 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 37/116 (31%), Positives = 62/116 (53%), Gaps = 2/116 (1%)

Query: 1   MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER 60
           M    Y   +T +SP G++ QIEYA+ AV  G+ +VG+K+    VL   K+ +S L   +
Sbjct: 1   MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ 60

Query: 61  SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVAS 116
              K+  +  HIG+  +G+  D R+L +  R+       V+  P+P ++LV  + S
Sbjct: 61  K--KILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGS 114


>gi|73747875 proteasome beta 8 subunit isoform E2 proprotein [Homo
           sapiens]
          Length = 276

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 23/219 (10%)

Query: 20  VQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILY-DERSVHKVEPITKHIGLVYSG 78
           VQIE     +A G  ++  K  +GV+ A + +  +  Y     V+KV  I  ++    SG
Sbjct: 65  VQIE-----MAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG 119

Query: 79  MGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICG 138
              D +       K  + YYL   E I  +   + ++++M +Y   G      +  +ICG
Sbjct: 120 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG----LSMGSMICG 175

Query: 139 WNEGRPYLFQSDPSGAYFAWK--ATAMGKNYVNGKTFLEKRYNEDLELEDAIH-----TA 191
           W++  P L+  D  G   +    +T  G  Y  G   ++  Y  +L  E+A        A
Sbjct: 176 WDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYG--VMDSGYRPNLSPEEAYDLGRRAIA 233

Query: 192 ILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYL 230
             T ++S+ G +    + +    E G+ ++  T+V D L
Sbjct: 234 YATHRDSYSGGV----VNMYHMKEDGWVKVESTDVSDLL 268


>gi|4758970 proteasome beta 8 subunit isoform E1 proprotein [Homo
           sapiens]
          Length = 272

 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 53/219 (24%), Positives = 94/219 (42%), Gaps = 23/219 (10%)

Query: 20  VQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILY-DERSVHKVEPITKHIGLVYSG 78
           VQIE     +A G  ++  K  +GV+ A + +  +  Y     V+KV  I  ++    SG
Sbjct: 61  VQIE-----MAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSG 115

Query: 79  MGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICG 138
              D +       K  + YYL   E I  +   + ++++M +Y   G      +  +ICG
Sbjct: 116 CAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMG----LSMGSMICG 171

Query: 139 WNEGRPYLFQSDPSGAYFAWK--ATAMGKNYVNGKTFLEKRYNEDLELEDAIH-----TA 191
           W++  P L+  D  G   +    +T  G  Y  G   ++  Y  +L  E+A        A
Sbjct: 172 WDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYG--VMDSGYRPNLSPEEAYDLGRRAIA 229

Query: 192 ILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYL 230
             T ++S+ G +    + +    E G+ ++  T+V D L
Sbjct: 230 YATHRDSYSGGV----VNMYHMKEDGWVKVESTDVSDLL 264


>gi|4506201 proteasome beta 5 subunit isoform 1 [Homo sapiens]
          Length = 263

 Score = 48.9 bits (115), Expect = 4e-06
 Identities = 37/161 (22%), Positives = 72/161 (44%), Gaps = 5/161 (3%)

Query: 32  GAPSVGIKAANGVVLATEKKQKSILY-DERSVHKVEPITKHIGLVYSGMGPDYRVLVHRA 90
           G  ++  K  +GV++A + +  +  Y   ++V KV  I  ++    +G   D        
Sbjct: 59  GTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLL 118

Query: 91  RKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSD 150
            +  + Y L  +E I  A   + +A+++ +Y   G      +  +ICGW++  P L+  D
Sbjct: 119 ARQCRIYELRNKERISVAAASKLLANMVYQYKGMG----LSMGTMICGWDKRGPGLYYVD 174

Query: 151 PSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTA 191
             G   +    ++G   V     +++ Y+ DLE+E A   A
Sbjct: 175 SEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLA 215


>gi|169206322 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 45/173 (26%), Positives = 70/173 (40%), Gaps = 42/173 (24%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAV-AGGAPSVGIKAANGVVLATEKKQKSILYDERSVH 63
           G+   L  FSP  +L Q++YA  A+  GG  SV ++  +  V+ T K     L D R+  
Sbjct: 92  GFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT-- 149

Query: 64  KVEPITKHIGLVYSGMGPDYRVLVHRAR-KLAQQYYLVYQEPIPTAQLVQRVASVMQEYT 122
            +  +TK+ G V +G+  D R    RA+ K A   Y +++E                   
Sbjct: 150 HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNIFEEL------------------ 191

Query: 123 QSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLE 175
                                P +++ D +G Y  +KATA G       +FLE
Sbjct: 192 --------------------GPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224


>gi|239750562 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 45/173 (26%), Positives = 70/173 (40%), Gaps = 42/173 (24%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAV-AGGAPSVGIKAANGVVLATEKKQKSILYDERSVH 63
           G+   L  FSP  +L Q++YA  A+  GG  SV ++  +  V+ T K     L D R+  
Sbjct: 92  GFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT-- 149

Query: 64  KVEPITKHIGLVYSGMGPDYRVLVHRAR-KLAQQYYLVYQEPIPTAQLVQRVASVMQEYT 122
            +  +TK+ G V +G+  D R    RA+ K A   Y +++E                   
Sbjct: 150 HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNIFEEL------------------ 191

Query: 123 QSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLE 175
                                P +++ D +G Y  +KATA G       +FLE
Sbjct: 192 --------------------GPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224


>gi|239744861 PREDICTED: similar to hCG30646 [Homo sapiens]
          Length = 272

 Score = 48.1 bits (113), Expect = 6e-06
 Identities = 45/173 (26%), Positives = 70/173 (40%), Gaps = 42/173 (24%)

Query: 5   GYSFSLTTFSPSGKLVQIEYALAAV-AGGAPSVGIKAANGVVLATEKKQKSILYDERSVH 63
           G+   L  FSP  +L Q++YA  A+  GG  SV ++  +  V+ T K     L D R+  
Sbjct: 92  GFDRHLIIFSPKVQLYQVQYAFKAINQGGLTSVAVRKKDCAVIVTHKIVPDKLLDSRT-- 149

Query: 64  KVEPITKHIGLVYSGMGPDYRVLVHRAR-KLAQQYYLVYQEPIPTAQLVQRVASVMQEYT 122
            +  +TK+ G V +G+  D R    RA+ K A   Y +++E                   
Sbjct: 150 HLFKMTKNTGRVITGVTADSRSREQRAQYKAANCKYNIFEEL------------------ 191

Query: 123 QSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLE 175
                                P +++ D +G Y  +KATA G       +FLE
Sbjct: 192 --------------------GPRVYKCDAAGYYCGFKATAAGVKQAESTSFLE 224


>gi|195539356 proteasome beta 5 subunit isoform 2 [Homo sapiens]
          Length = 160

 Score = 41.6 bits (96), Expect = 6e-04
 Identities = 29/104 (27%), Positives = 50/104 (48%), Gaps = 7/104 (6%)

Query: 91  RKLAQQ---YYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLF 147
           R LA+Q   Y L  +E I  A   + +A+++ +Y   G      +  +ICGW++  P L+
Sbjct: 13  RLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMG----LSMGTMICGWDKRGPGLY 68

Query: 148 QSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTA 191
             D  G   +    ++G   V     +++ Y+ DLE+E A   A
Sbjct: 69  YVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLA 112


>gi|4506191 proteasome beta 10 subunit proprotein [Homo sapiens]
          Length = 273

 Score = 36.2 bits (82), Expect = 0.025
 Identities = 49/207 (23%), Positives = 85/207 (41%), Gaps = 25/207 (12%)

Query: 32  GAPSVGIKAANGVVLATEKK--QKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHR 89
           G    G+   +GV+L  + +    S++ D +S  K+  I   I    +G+  D  +    
Sbjct: 39  GTTIAGLVFQDGVILGADTRATNDSVVAD-KSCEKIHFIAPKIYCCGAGVAADAEMTTRM 97

Query: 90  -ARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQS-----GGVRPFGVSLLICGWNEGR 143
            A K+        +EP        RVA+V +   Q+     G V   G SL++ G +   
Sbjct: 98  VASKMELHALSTGREP--------RVATVTRILRQTLFRYQGHV---GASLIVGGVDLTG 146

Query: 144 PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQM 203
           P L+   P G+Y     TA+G         LE R+  ++ LE A    +  +     G +
Sbjct: 147 PQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDL 206

Query: 204 -TEDNIEVGICNEAGFRRL----TPTE 225
            +  N++  +  + G + L    +PTE
Sbjct: 207 GSGGNVDACVITKTGAKLLRTLSSPTE 233


>gi|153791216 proteasome beta 11 subunit [Homo sapiens]
          Length = 300

 Score = 34.3 bits (77), Expect = 0.095
 Identities = 37/164 (22%), Positives = 68/164 (41%), Gaps = 13/164 (7%)

Query: 29  VAGGAPSVGIKAANGVVLATEKKQKSILYDERSVH-KVEPITKHIGLVYSGMGPD----Y 83
           +A G  ++  +  +GV+ A + +     Y       KV P+ +H+    SG   D    Y
Sbjct: 46  LAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWY 105

Query: 84  RVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGR 143
           RVL  R  +L +    + +  +P+     ++ S M   +Q  G+    V+  +CGW+   
Sbjct: 106 RVL-QRELRLRE----LREGQLPSVASAAKLLSAMM--SQYRGL-DLCVATALCGWDRSG 157

Query: 144 PYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDA 187
           P LF     G        ++G         L++ Y  D+  ++A
Sbjct: 158 PELFYVYSDGTRLQGDIFSVGSGSPYAYGVLDRGYRYDMSTQEA 201


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 30.8 bits (68), Expect = 1.0
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 163 MGKNYVNGKTF-LEKRYNEDLELEDAIHTAILTLKESFE--GQMTEDNIEVGICNEAGFR 219
           MG+     +TF L + Y E ++L+ +       LK  FE  GQ++E  I+  I  E   R
Sbjct: 415 MGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARR 474

Query: 220 RLTPTEVKD 228
           R    E+K+
Sbjct: 475 RAIDLEIKE 483


>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score = 30.0 bits (66), Expect = 1.8
 Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 4/36 (11%)

Query: 134 LLICGWN----EGRPYLFQSDPSGAYFAWKATAMGK 165
           +L+  W+    +G  YLF+ DPS  YF+W     G+
Sbjct: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGR 201


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score = 30.0 bits (66), Expect = 1.8
 Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 4/36 (11%)

Query: 134 LLICGWN----EGRPYLFQSDPSGAYFAWKATAMGK 165
           +L+  W+    +G  YLF+ DPS  YF+W     G+
Sbjct: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGR 201


>gi|22748615 hypothetical protein LOC90488 [Homo sapiens]
          Length = 116

 Score = 30.0 bits (66), Expect = 1.8
 Identities = 17/43 (39%), Positives = 24/43 (55%)

Query: 12  TFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKS 54
           T  PS  +  ++  ++AVAGG  +VG    N V L  +KK KS
Sbjct: 73  TTVPSMGIGLVKGGVSAVAGGVTAVGSAVVNKVPLTGKKKDKS 115


>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
          Length = 963

 Score = 29.6 bits (65), Expect = 2.3
 Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 5/68 (7%)

Query: 127 VRPFGVSLLICGWNEGRPYLFQ----SDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDL 182
           +R   +S  +C  +  RPY++     S+  GA      TA  KN +NGK +     N  L
Sbjct: 846 IRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSL 904

Query: 183 ELEDAIHT 190
             ED I T
Sbjct: 905 ASEDQIVT 912


>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
          Length = 916

 Score = 29.6 bits (65), Expect = 2.3
 Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 5/68 (7%)

Query: 127 VRPFGVSLLICGWNEGRPYLFQ----SDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDL 182
           +R   +S  +C  +  RPY++     S+  GA      TA  KN +NGK +     N  L
Sbjct: 799 IRGLNMSEFVCNLS-ARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSL 857

Query: 183 ELEDAIHT 190
             ED I T
Sbjct: 858 ASEDQIVT 865


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,843,790
Number of Sequences: 37866
Number of extensions: 375543
Number of successful extensions: 706
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 655
Number of HSP's gapped (non-prelim): 35
length of query: 234
length of database: 18,247,518
effective HSP length: 99
effective length of query: 135
effective length of database: 14,498,784
effective search space: 1957335840
effective search space used: 1957335840
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.