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Search of human proteins with 13124888
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13124888 epidermal growth factor-like protein 6 precursor
[Homo sapiens]
(553 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13124888 epidermal growth factor-like protein 6 precursor [Ho... 1183 0.0
gi|75709198 nephronectin [Homo sapiens] 416 e-116
gi|56237021 fibrillin 3 precursor [Homo sapiens] 148 1e-35
gi|66346695 fibrillin 2 precursor [Homo sapiens] 144 3e-34
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 142 1e-33
gi|24430141 fibrillin 1 precursor [Homo sapiens] 136 4e-32
gi|110347437 latent transforming growth factor beta binding prot... 134 2e-31
gi|110347412 latent transforming growth factor beta binding prot... 134 2e-31
gi|110347431 latent transforming growth factor beta binding prot... 134 2e-31
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 131 1e-30
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 131 1e-30
gi|118572606 hemicentin 1 [Homo sapiens] 129 5e-30
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens] 128 2e-29
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 127 3e-29
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 121 1e-27
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 121 1e-27
gi|34734066 fibulin 1 isoform D [Homo sapiens] 121 1e-27
gi|62548862 matrilin 2 isoform b precursor [Homo sapiens] 119 9e-27
gi|62548860 matrilin 2 isoform a precursor [Homo sapiens] 119 9e-27
gi|190343004 EGF-containing fibulin-like extracellular matrix pr... 118 2e-26
gi|4557733 latent transforming growth factor beta binding protei... 115 8e-26
gi|46249414 latent transforming growth factor beta binding prote... 114 2e-25
gi|46249412 latent transforming growth factor beta binding prote... 114 2e-25
gi|19743803 fibulin 5 precursor [Homo sapiens] 114 3e-25
gi|194328809 latent transforming growth factor beta binding prot... 110 3e-24
gi|18497288 latent transforming growth factor beta binding prote... 110 3e-24
gi|40807489 egf-like module containing, mucin-like, hormone rece... 110 3e-24
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 110 4e-24
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 109 6e-24
gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens] 109 6e-24
>gi|13124888 epidermal growth factor-like protein 6 precursor [Homo
sapiens]
Length = 553
Score = 1183 bits (3060), Expect = 0.0
Identities = 553/553 (100%), Positives = 553/553 (100%)
Query: 1 MPLPWSLALPLLLSWVAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGV 60
MPLPWSLALPLLLSWVAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGV
Sbjct: 1 MPLPWSLALPLLLSWVAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGV 60
Query: 61 CEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
CEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC
Sbjct: 61 CEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
Query: 121 LSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS 180
LSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS
Sbjct: 121 LSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS 180
Query: 181 GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ
Sbjct: 181 GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
Query: 241 GSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAHKNSMKKKAKIKNVT 300
GSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAHKNSMKKKAKIKNVT
Sbjct: 241 GSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAHKNSMKKKAKIKNVT 300
Query: 301 PEPTRTPTPKVNLQPFNYEEIVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKNDIEER 360
PEPTRTPTPKVNLQPFNYEEIVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKNDIEER
Sbjct: 301 PEPTRTPTPKVNLQPFNYEEIVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKNDIEER 360
Query: 361 SLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISVDCSFNHGICDWKQDREDDFD 420
SLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISVDCSFNHGICDWKQDREDDFD
Sbjct: 361 SLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISVDCSFNHGICDWKQDREDDFD 420
Query: 421 WNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVGKLRV 480
WNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVGKLRV
Sbjct: 421 WNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDKVGKLRV 480
Query: 481 FVKNSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLV 540
FVKNSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLV
Sbjct: 481 FVKNSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEIAVDGVLLV 540
Query: 541 SGLCPDSLLSVDD 553
SGLCPDSLLSVDD
Sbjct: 541 SGLCPDSLLSVDD 553
>gi|75709198 nephronectin [Homo sapiens]
Length = 565
Score = 416 bits (1068), Expect = e-116
Identities = 215/554 (38%), Positives = 312/554 (56%), Gaps = 70/554 (12%)
Query: 39 GVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNEC 98
G+C YG ++ CC+GW R S G C+ C+P CK GEC+GPNKC+C PGY GKTC+QD+NEC
Sbjct: 34 GLCRYGGRIDCCWGWARQSWGQCQPVCQPRCKHGECIGPNKCKCHPGYAGKTCNQDLNEC 93
Query: 99 GMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCLC 158
G+KPRPC+HRC+NT+GSYKC+CL+G+MLMPD +C ++ TC+M NCQY C+ + +C C
Sbjct: 94 GLKPRPCKHRCMNTYGSYKCYCLNGYMLMPDGSCSSALTCSMANCQYGCDVVKGQIRCQC 153
Query: 159 PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCI 218
PS GL+LAP+GR C+D+DECA+G+ CP R+CVNTFGSY CKCH GF+L YI G+Y C
Sbjct: 154 PSPGLQLAPDGRTCVDVDECATGRASCPRFRQCVNTFGSYICKCHKGFDLMYIGGKYQCH 213
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVK-----EVLRAP 273
DI+EC++ + CS A C+N +GS+KCKCK+GY+G+GL C IP+ ++ V +
Sbjct: 214 DIDECSLGQYQCSSFARCYNIRGSYKCKCKEGYQGDGLTCVYIPKVMIEPSGPIHVPKGN 273
Query: 274 GTI----------------------KDRIKKLLAHKNSMKKKAKIKNVTPEPTRTPTP-- 309
GTI I ++ ++ + K + TP+PT PTP
Sbjct: 274 GTILKGDTGNNNWIPDVGSTWWPPKTPYIPPIITNRPTSKPTTR---PTPKPTPIPTPPP 330
Query: 310 --------KVNLQPFNYEE------IVSRGGNSHGGKKGNEEKMKEGLEDEKREEKALKN 355
+ L P E ++ ++ G G+ + R +
Sbjct: 331 PPPLPTELRTPLPPTTPERPTTGLTTIAPAASTPPG----------GITVDNRVQ----- 375
Query: 356 DIEERSLRGDVFFPKVNEAGEFGLILVQRKALTSKLEHKDLNISV-DCSFNHGICDWKQD 414
+ + RGDVF P+ F + ++R D + V C+F+HG+C W ++
Sbjct: 376 -TDPQKPRGDVFIPRQPSNDLFEIFEIERGVSADDEAKDDPGVLVHSCNFDHGLCGWIRE 434
Query: 415 REDDFDWNPADRDNAIGFYMAVPALAGHKKDIGRLKLLLPDLQPQSNFCLLFDYRLAGDK 474
+++D W P RD A G Y+ V A RL L L L + CL F +++ G
Sbjct: 435 KDNDLHWEPI-RDPAGGQYLTVSAAKAPGGKAARLVLPLGRLMHSGDLCLSFRHKVTGLH 493
Query: 475 VGKLRVFVK--NSNNALAWEKTTSEDEKWKTGKIQLYQGTDATKSIIFEAERGKGKTGEI 532
G L+VFV+ ++ A W + W+ +I L +G D KS++F+ E+ +G TGEI
Sbjct: 494 SGTLQVFVRKHGAHGAALWGRNGGHG--WRQTQITL-RGAD-IKSVVFKGEKRRGHTGEI 549
Query: 533 AVDGVLLVSGLCPD 546
+D V L G C +
Sbjct: 550 GLDDVSLKKGHCSE 563
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 148 bits (374), Expect = 1e-35
Identities = 87/253 (34%), Positives = 120/253 (47%), Gaps = 28/253 (11%)
Query: 35 ARQPGVCHYGT--------KLACCYGWRRNSKGVC-----EATCEPG-CKFGECV---GP 77
AR P +C GT K C G +KG E + G C G+CV G
Sbjct: 1076 ARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGA 1135
Query: 78 NKCRCFPGYTGKTCSQ---DVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCV 133
+C C G+ Q D+NEC ++ C C+NT GSY+C C G+ LMPD C
Sbjct: 1136 FQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACA 1195
Query: 134 NSRTCA---MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRR 190
+ C + Q C + G +CLC G P+ R C+D+DEC IC +
Sbjct: 1196 DVDECEENPRVCDQGHCTNMPGGHRCLC-YDGFMATPDMRTCVDVDECDLNPHICLHGD- 1253
Query: 191 CVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQG 250
C NT GS+ C C +G+ ++ G C D++EC + H C HA+C N GSF C+C G
Sbjct: 1254 CENTKGSFVCHCQLGYMVR--KGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPG 1311
Query: 251 YKGNGLRCSAIPE 263
+ G+G C + E
Sbjct: 1312 WVGDGFECHDLDE 1324
Score = 129 bits (323), Expect = 9e-30
Identities = 78/227 (34%), Positives = 115/227 (50%), Gaps = 23/227 (10%)
Query: 45 TKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRP 104
T+ CC G R CE PG + P+ GYT + +DV+EC M
Sbjct: 2320 TRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGS----GYTAE--GRDVDECRMLAHL 2373
Query: 105 CQH-RCVNTHGSYKCFCLSGHMLMPDAT---CVNSRTCAMIN--CQYSCEDTEEGPQCLC 158
C H C+N+ GS++C C +G+ PDAT C++ C+ + C + C++T+ C C
Sbjct: 2374 CAHGECINSLGSFRCHCQAGYT--PDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSC 2431
Query: 159 PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCI 218
P G L +GR C D+DEC S + C + CVNT G++ C+C GF + + C
Sbjct: 2432 PR-GYLLEEDGRTCKDLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQA----CF 2484
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAIPE 263
D +EC+ C H +C NT GSF+C+C QG+ +G C + E
Sbjct: 2485 DNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNE 2531
Score = 120 bits (300), Expect = 4e-27
Identities = 72/203 (35%), Positives = 97/203 (47%), Gaps = 20/203 (9%)
Query: 69 CKFGECV---GPNKCRCFPGYTGKT---CSQDVNECGMKPRPCQHR--CVNTHGSYKCFC 120
C G C+ G +C C G+ + +DV+ECG + PCQ C+N GSY+C C
Sbjct: 1732 CANGICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791
Query: 121 LSGHMLMPDATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
G+ L P CV C I C + C DTE CLC G + + + C+DIDE
Sbjct: 1792 TRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLC-HRGFQASADQTLCMDIDE 1850
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCF 237
C + C N C N GSY C C GF ++ DC+D +ECT +C
Sbjct: 1851 C--DRQPCG-NGTCKNIIGSYNCLCFPGF---VVTHNGDCVDFDECTTLVGQVCRFGHCL 1904
Query: 238 NTQGSFKCKCKQGYK--GNGLRC 258
NT GSF C C+ G++ +G C
Sbjct: 1905 NTAGSFHCLCQDGFELTADGKNC 1927
Score = 107 bits (266), Expect = 4e-23
Identities = 73/228 (32%), Positives = 107/228 (46%), Gaps = 27/228 (11%)
Query: 49 CCYGWRRNSKGVCEATCE----PG-CKFGECV---GPNKCRCFPGYTG---KTCSQDVNE 97
C G++ + G C E P C G+C+ G C C G+ +T D++E
Sbjct: 1791 CTRGYKLSPGGACVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDE 1850
Query: 98 CGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMIN---CQYS-CEDTEE 152
C +P C + C N GSY C C G ++ + CV+ C + C++ C +T
Sbjct: 1851 CDRQP--CGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAG 1908
Query: 153 GPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYIS 212
CLC G L +G++C+D +EC S C C N GS+ C C GF++Q
Sbjct: 1909 SFHCLC-QDGFELTADGKNCVDTNECLSLAGTC-LPGTCQNLEGSFRCICPPGFQVQ--- 1963
Query: 213 GRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY--KGNGLRC 258
CIDI+EC+ + + C C N+ GSF+C C G+ NG RC
Sbjct: 1964 -SDHCIDIDECSEEPNLCLF-GTCTNSPGSFQCLCPPGFVLSDNGHRC 2009
Score = 106 bits (264), Expect = 6e-23
Identities = 69/192 (35%), Positives = 97/192 (50%), Gaps = 19/192 (9%)
Query: 69 CKFGECV---GPNKCRCFPGYTGKTCSQ--DVNECGMKPRPCQH-RCVNTHGSYKCFCLS 122
C G C+ +C C GYT + DV+EC PC H CVN G+Y C C
Sbjct: 419 CLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDEC--TSSPCHHGDCVNIPGTYHCRCYP 476
Query: 123 GHMLMPD-ATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDEC 178
G P CV+ C + C C +TE QC+C ++G L+P+G++C+D +EC
Sbjct: 477 GFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVC-NAGFELSPDGKNCVDHNEC 535
Query: 179 ASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFN 238
A+ + N C+N GS+ C C GF L G + C+DI+EC + H C N
Sbjct: 536 ATSTMC--VNGVCLNEDGSFSCLCKPGFLL--APGGHYCMDIDECQTPGICVNGH--CTN 589
Query: 239 TQGSFKCKCKQG 250
T+GSF+C+C G
Sbjct: 590 TEGSFRCQCLGG 601
Score = 105 bits (261), Expect = 1e-22
Identities = 92/304 (30%), Positives = 135/304 (44%), Gaps = 28/304 (9%)
Query: 55 RNSKGVCEATC-EPGCKF--GECVGPNKCRCFPGYTG--KTCSQDVNECGMKPRPC--QH 107
R K + E T + C+F VG CRC PG+T + C D +EC +P PC
Sbjct: 2442 RTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACF-DNDECSAQPGPCGAHG 2500
Query: 108 RCVNTHGSYKCFCLSGHMLMPDAT-CVNSRTC-AMINCQYSCEDTEEGPQCLCPSSGLRL 165
C NT GS++C C G L+ C + C CQ+ C++ G +C CP G
Sbjct: 2501 HCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQ-GFTQ 2559
Query: 166 APNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTM 225
C+D +ECA C + C NT G + C C GF+ G C +++EC
Sbjct: 2560 HSQWAQCVDENECALSPPTCG-SASCRNTLGGFRCVCPSGFDFDQALG--GCQEVDECAG 2616
Query: 226 DSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLA 285
CS+ +C NT G F C C QGY G + V + +PG K+ L
Sbjct: 2617 RRGPCSY--SCANTPGGFLCGCPQGYFRAG------QGHCVSGLGFSPGPQDTPDKEELL 2668
Query: 286 HKNSMKKKAKIKNVTP--EPTRTP--TPKVNLQPFNYEEIVSRGGN-SHGGKKGNEEKMK 340
+ + KI ++P P R+ +VNL + E +++ G N SH G+ +++
Sbjct: 2669 SSEAC-YECKINGLSPRDRPRRSAHRDHQVNLATLDSEALLTLGLNLSHLGRAERILELR 2727
Query: 341 EGLE 344
LE
Sbjct: 2728 PALE 2731
Score = 100 bits (250), Expect = 3e-21
Identities = 78/239 (32%), Positives = 107/239 (44%), Gaps = 27/239 (11%)
Query: 49 CCYGWRRNSKGVC----EATCEPGCKFGECV---GPNKCRCFPGYTGKTCSQ---DVNEC 98
C G+ ++ +G C E T P C G+CV G CRC+PG+ Q DV+EC
Sbjct: 435 CNVGYTQDVRGECIDVDECTSSP-CHHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDEC 493
Query: 99 GMKPRPCQ-HRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMINCQYS--CEDTEEGP 154
+ C RCVNT GS++C C +G L PD CV+ CA + C + +
Sbjct: 494 IVSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSF 553
Query: 155 QCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGR 214
CLC G LAP G C+DIDEC + + N C NT GS+ C+C G + GR
Sbjct: 554 SCLC-KPGFLLAPGGHYCMDIDECQTPGIC--VNGHCTNTEGSFRCQCLGGLAVG-TDGR 609
Query: 215 YDCIDI---NEC--TMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKE 268
C+D + C ++ +C+ T +C C G G C P E
Sbjct: 610 V-CVDTHVRSTCYGAIEKGSCARPFP--GTVTKSECCCANPDHGFGEPCQLCPAKDSAE 665
Score = 98.2 bits (243), Expect = 2e-20
Identities = 63/189 (33%), Positives = 90/189 (47%), Gaps = 15/189 (7%)
Query: 87 TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML-MPDATCVNSRTCAM---I 141
+G+ +DVNEC + P C H C NT GS+ C C G L + C + C + +
Sbjct: 979 SGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDL 1038
Query: 142 NCQYSCEDTEEGPQCLC---PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSY 198
Q +C +T +C C SG L N C+D+DECA ++C C NT GSY
Sbjct: 1039 CGQGTCVNTPGSFECECFPGYESGFMLMKN---CMDVDECARDPLLCR-GGTCTNTDGSY 1094
Query: 199 YCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRC 258
C+C G EL + C DI+EC++ C H C N G+F+C C G++ R
Sbjct: 1095 KCQCPPGHELT--AKGTACEDIDECSLSDGLCPH-GQCVNVIGAFQCSCHAGFQSTPDRQ 1151
Query: 259 SAIPENSVK 267
+ N +
Sbjct: 1152 GCVDINECR 1160
Score = 95.9 bits (237), Expect = 9e-20
Identities = 81/257 (31%), Positives = 112/257 (43%), Gaps = 34/257 (13%)
Query: 35 ARQPGVCHYGT--------KLACCYGWRRNSKGV-CEAT--CEPG--CKFGEC---VGPN 78
A PGVC G + C +G+ + G+ C T C G C G C +G
Sbjct: 2089 AENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGF 2148
Query: 79 KCRCFPGYTG---KTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVN 134
+C C G+ TC +D++EC + P C RC NT GSY C C +G+ L D A C +
Sbjct: 2149 ECACADGFEPGLMMTC-EDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRD 2207
Query: 135 SRTCA--MINCQ---YSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNR 189
CA +C C++ C+CP L +G C D +EC + +C N
Sbjct: 2208 VDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLC-VNG 2266
Query: 190 RCVNTFGSYYCKCHIGFELQYISGRYDCIDINE--CTMD--SHTCSHHANCFNTQGSFKC 245
RCVNT GS+ C C GF Q +C DI + C + C ++ +C
Sbjct: 2267 RCVNTAGSFRCDCDEGF--QPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAEC 2324
Query: 246 KCKQGYKGNGLRCSAIP 262
C G +G G RC P
Sbjct: 2325 CCGGG-RGWGPRCELCP 2340
Score = 93.2 bits (230), Expect = 6e-19
Identities = 70/230 (30%), Positives = 96/230 (41%), Gaps = 48/230 (20%)
Query: 67 PG-CKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPC-QHRCVNTHGSYK 117
PG C+ G+CV G +C C PGY + C +D++EC C C NT G+Y
Sbjct: 1571 PGLCQGGDCVNTFGSFQCECPPGYHLSEHTRIC-EDIDECSTHSGICGPGTCYNTLGNYT 1629
Query: 118 CFCLSGHMLMP-----------------DATCVNSR----TCAMINCQYSCEDTEEGPQC 156
C C + ++ + + TC N T M C Y+ P
Sbjct: 1630 CVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNIGQAWNRPCE 1689
Query: 157 LCPSS--------------GLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKC 202
CP+ G + LDIDEC IC N C+N GS+ C+C
Sbjct: 1690 ACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAICA-NGICINQIGSFRCEC 1748
Query: 203 HIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
GF Y S C D++EC C +A+C N GS++CKC +GYK
Sbjct: 1749 PAGFN--YNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYK 1796
Score = 90.9 bits (224), Expect = 3e-18
Identities = 54/164 (32%), Positives = 78/164 (47%), Gaps = 8/164 (4%)
Query: 90 TCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQY-SC 147
T +Q ++ C C + RC+ T SY+C C G+ C++ C C + C
Sbjct: 404 TLNQTIDICRHFTNLCLNGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGDC 463
Query: 148 EDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFE 207
+ C C G + P + C+D+DEC +C + RCVNT GS+ C C+ GFE
Sbjct: 464 VNIPGTYHCRC-YPGFQATPTRQACVDVDECIVSGGLC-HLGRCVNTEGSFQCVCNAGFE 521
Query: 208 LQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
L +C+D NEC + T + C N GSF C CK G+
Sbjct: 522 LS--PDGKNCVDHNECA--TSTMCVNGVCLNEDGSFSCLCKPGF 561
Score = 90.9 bits (224), Expect = 3e-18
Identities = 73/249 (29%), Positives = 105/249 (42%), Gaps = 61/249 (24%)
Query: 69 CKFGECV---GPNKCRCFPGYTG----KTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFC 120
C G C G ++C C+ G+ +TC DV+EC + P C H C NT GS+ C C
Sbjct: 1207 CDQGHCTNMPGGHRCLCYDGFMATPDMRTCV-DVDECDLNPHICLHGDCENTKGSFVCHC 1265
Query: 121 LSGHMLMPDAT--------------CVNSRTCAMINCQYSCEDTE----EGPQCL----C 158
G+M+ AT C + +C I +SC +G +C C
Sbjct: 1266 QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDEC 1325
Query: 159 PSSGLRLAPNGRDCLDI----------------------DECASGKVICPYNRRCVNTFG 196
S R +P G DCL++ DECA +C N +C+N G
Sbjct: 1326 VSQEHRCSPRG-DCLNVPGSYRCTCRQGFAGDGFFCEDRDECAENVDLCD-NGQCLNAPG 1383
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GN 254
Y C+C +GF+ C D++EC + C+ +C N G F+C C GY+
Sbjct: 1384 GYRCECEMGFD--PTEDHRACQDVDECA-QGNLCA-FGSCENLPGMFRCICNGGYELDRG 1439
Query: 255 GLRCSAIPE 263
G C+ I E
Sbjct: 1440 GGNCTDINE 1448
Score = 89.7 bits (221), Expect = 6e-18
Identities = 86/295 (29%), Positives = 115/295 (38%), Gaps = 72/295 (24%)
Query: 41 CHYGTKLACCYGWRRNSKGVCEATCEPGCKFGEC----------------VGPNKCRCFP 84
C TK C W + + CE + EC + P R F
Sbjct: 804 CLDSTKGTC---WLKIQESRCEVNLQGASLRSECCATLGAAWGSPCERCEIDPACARGFA 860
Query: 85 GYTGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML----------------- 126
TG TC DVNEC P C + RCVNT GS++C C G ML
Sbjct: 861 RMTGVTCD-DVNECESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFL 919
Query: 127 ----------MP-----DATCVNSRTCAMINCQYSCEDTEEGP-QCLCPSSGLRLAPNGR 170
+P D C + + C+ +C D E LCP GL A R
Sbjct: 920 RWDEDECGVTLPGKYRMDVCCCSIGAVWGVECE-ACPDPESLEFASLCP-RGLGFA--SR 975
Query: 171 DCL-------DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC 223
D L D++EC +C + C NT GS++C C GF L + +C DI+EC
Sbjct: 976 DFLSGRPFYKDVNECKVFPGLCTHG-TCRNTVGSFHCACAGGFALD--AQERNCTDIDEC 1032
Query: 224 TMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGL---RCSAIPENSVKEVLRAPGT 275
+ C C NT GSF+C+C GY+ + C + E + +L GT
Sbjct: 1033 RISPDLCG-QGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT 1086
Score = 80.5 bits (197), Expect = 4e-15
Identities = 70/231 (30%), Positives = 87/231 (37%), Gaps = 56/231 (24%)
Query: 69 CKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCL 121
C FG C G +C C GY G C+ D+NEC C+NT GSY C C
Sbjct: 1414 CAFGSCENLPGMFRCICNGGYELDRGGGNCT-DINECADPVNCINGVCINTPGSYLCSCP 1472
Query: 122 SGHMLMPDAT-CVNSRTCAMINCQYSCEDT-EEGPQC----------------------- 156
L P CV++R NC D + G C
Sbjct: 1473 QDFELNPSGVGCVDTRAG---NCFLETHDRGDSGISCSAEIGVGVTRASCCCSLGRAWGN 1529
Query: 157 ---LCPSSGL----RLAPNGRD---------CLDIDECASGKVICPYNRRCVNTFGSYYC 200
LCP + L P G DIDEC +C CVNTFGS+ C
Sbjct: 1530 PCELCPMANTTEYRTLCPGGEGFQPNRITVILEDIDECQELPGLC-QGGDCVNTFGSFQC 1588
Query: 201 KCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
+C G+ L C DI+EC+ S C C+NT G++ C C Y
Sbjct: 1589 ECPPGYHLS--EHTRICEDIDECSTHSGICG-PGTCYNTLGNYTCVCPAEY 1636
Score = 79.7 bits (195), Expect = 6e-15
Identities = 67/230 (29%), Positives = 93/230 (40%), Gaps = 31/230 (13%)
Query: 38 PGVCHYGT--------KLACCYGWRRNSKG-VC-----EATCEPGCKFGECVGPNKCRCF 83
PG+C G + C G + G VC +TC + G C P F
Sbjct: 579 PGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARP-----F 633
Query: 84 PGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAM--- 140
PG K+ N PCQ ++ C SG + D +N CA+
Sbjct: 634 PGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINE--CALDPE 691
Query: 141 INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYC 200
+ CE+ +C+C + G +G+DC D+DECA ++C N C N+ GSY C
Sbjct: 692 VCANGVCENLRGSYRCVC-NLGYEAGASGKDCTDVDECALNSLLCD-NGWCQNSPGSYSC 749
Query: 201 KCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQG 250
C GF + C D++EC S C C N GS+ CKC G
Sbjct: 750 SCPPGF--HFWQDTEICKDVDECL--SSPCVSGV-CRNLAGSYTCKCGPG 794
Score = 79.0 bits (193), Expect = 1e-14
Identities = 63/220 (28%), Positives = 92/220 (41%), Gaps = 63/220 (28%)
Query: 46 KLACC-----YGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGY-----TGKTCSQDV 95
K+ CC W R CEA P + + N+ PG+ TGK D+
Sbjct: 1672 KMCCCSYNIGQAWNRP----CEACPTPISPDYQILCGNQA---PGFLTDIHTGKPL--DI 1722
Query: 96 NECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGP 154
+ECG P C + C+N GS++C C +G
Sbjct: 1723 DECGEIPAICANGICINQIGSFRCECPAGFNY---------------------------- 1754
Query: 155 QCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGR 214
+ + LA C D+DEC S + C N C+N GSY CKC G++L S
Sbjct: 1755 ------NSILLA-----CEDVDECGSRESPCQQNADCINIPGSYRCKCTRGYKL---SPG 1800
Query: 215 YDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN 254
C+ NEC + CS H +C +T+GS+ C C +G++ +
Sbjct: 1801 GACVGRNECREIPNVCS-HGDCMDTEGSYMCLCHRGFQAS 1839
Score = 78.6 bits (192), Expect = 1e-14
Identities = 66/239 (27%), Positives = 99/239 (41%), Gaps = 32/239 (13%)
Query: 49 CCYGWRRNSKGVCEATCEPGCKFGE----CVGPNKCRCFPGYTGKTCS--QDVNE----- 97
C +G NS G + C PG + C + CF + CS + N
Sbjct: 1980 CLFGTCTNSPGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRC 2039
Query: 98 -CGMKPR-----PCQHRCVNTHGSYKCFCLSGHMLMP--DATCVNSRTCAM---INCQYS 146
C +P PC+ +++ C GH +P D + + CA +
Sbjct: 2040 CCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGV 2099
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGF 206
C +T+ +C CP G L G +C+D DEC+ G C C N G + C C GF
Sbjct: 2100 CVNTDGSFRCECPF-GYSLDFTGINCVDTDECSVGHP-CGQGT-CTNVIGGFECACADGF 2156
Query: 207 ELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY--KGNGLRCSAIPE 263
E + C DI+EC+++ C+ C NT+GS+ C C GY + +G C + E
Sbjct: 2157 EPGLMM---TCEDIDECSLNPLLCAF--RCHNTEGSYLCTCPAGYTLREDGAMCRDVDE 2210
Score = 75.1 bits (183), Expect = 2e-13
Identities = 64/206 (31%), Positives = 85/206 (41%), Gaps = 41/206 (19%)
Query: 74 CVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDATC 132
CV P R PG +G+ C+ D NEC +P C + RCVNT GS++C C G P T
Sbjct: 2234 CVCPPGMRPLPG-SGEGCTDD-NECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLT- 2290
Query: 133 VNSRTCAMINCQYSCEDTEEGP------QCLCPS-SGLRLAPNGRDCLDIDECASGKVIC 185
C D +GP Q +C S S A +C C G+
Sbjct: 2291 -------------ECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECC----CGGGRGWG 2333
Query: 186 PYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC 245
P C S Y K GR D++EC M +H C+H C N+ GSF+C
Sbjct: 2334 PRCELCPLPGTSAYRKLCPHGSGYTAEGR----DVDECRMLAHLCAH-GECINSLGSFRC 2388
Query: 246 KCKQGYKGNGL--------RCSAIPE 263
C+ GY + CS +P+
Sbjct: 2389 HCQAGYTPDATATTCLDMDECSQVPK 2414
Score = 70.5 bits (171), Expect = 4e-12
Identities = 72/253 (28%), Positives = 94/253 (37%), Gaps = 65/253 (25%)
Query: 47 LACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQ 106
L C GW +NS G +C PG F + +DV+EC PC
Sbjct: 733 LLCDNGWCQNSPGSYSCSCPPGFHF--------------WQDTEICKDVDEC--LSSPCV 776
Query: 107 HR-CVNTHGSYKCFCLSGHMLMPDAT--------------------------CVNSRTCA 139
C N GSY C C G L P T + S CA
Sbjct: 777 SGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCA 836
Query: 140 MINCQYS--CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGS 197
+ + CE E P C + + G C D++EC S +CP N RCVNT GS
Sbjct: 837 TLGAAWGSPCERCEIDPACARGFARM----TGVTCDDVNECESFPGVCP-NGRCVNTAGS 891
Query: 198 YYCKCHIGFELQYISGRYDCIDI--NECTM--DSHTCSHHANCFNTQGSFK---CKCKQG 250
+ C+C G L SGR C+D+ C + D C G ++ C C G
Sbjct: 892 FRCECPEGLMLD-ASGRL-CVDVRLEPCFLRWDEDECG-----VTLPGKYRMDVCCCSIG 944
Query: 251 YKGNGLRCSAIPE 263
G+ C A P+
Sbjct: 945 AVW-GVECEACPD 956
Score = 66.2 bits (160), Expect = 7e-11
Identities = 51/195 (26%), Positives = 74/195 (37%), Gaps = 41/195 (21%)
Query: 26 ARHHGLLASARQPGVCHYGTKLACCYGWRRNSKG--VCEATCEPGCKFGECVGPNKCRCF 83
+R G S G C G C G+ G +C+ C G G C+GPN+C C
Sbjct: 115 SRGSGCSVSCMNGGTCR-GASCLCQKGYTGTVCGQPICDRGCHNG---GRCIGPNRCACV 170
Query: 84 PGYTGKTCSQD--VNEC--GMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCA 139
G+ G C +D C + P CQH+ + C + CA
Sbjct: 171 YGFMGPQCERDYRTGPCFGQVGPEGCQHQ------------------LTGLVCTKALCCA 212
Query: 140 MINCQYSCEDTEEGPQCLCPSS------GLRLAPNGRDCLDIDECASGKVICPYNRRCVN 193
+ + P LCP+ G + C D+DEC + +C CVN
Sbjct: 213 TVGRAWGL------PCELCPAQPHPCRRGFIPNIHTGACQDVDECQAVPGLC-QGGSCVN 265
Query: 194 TFGSYYCKCHIGFEL 208
GS++C+C +G L
Sbjct: 266 MVGSFHCRCPVGHRL 280
Score = 60.8 bits (146), Expect = 3e-09
Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 7/87 (8%)
Query: 175 IDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHA 234
ID C +C N RC+ T SY C+C++G+ R +CID++ECT S C HH
Sbjct: 409 IDICRHFTNLC-LNGRCLPTPSSYRCECNVGYTQDV---RGECIDVDECT--SSPC-HHG 461
Query: 235 NCFNTQGSFKCKCKQGYKGNGLRCSAI 261
+C N G++ C+C G++ R + +
Sbjct: 462 DCVNIPGTYHCRCYPGFQATPTRQACV 488
Score = 56.2 bits (134), Expect = 8e-08
Identities = 71/281 (25%), Positives = 96/281 (34%), Gaps = 56/281 (19%)
Query: 11 LLLSW-----VAGGFGNAASA---------RHHGLLASARQPGVCHYGTKLACCYGWRR- 55
LLL+W +AGG G A R G + P VC CC GWR
Sbjct: 16 LLLAWSALLCMAGGQGRWDGALEAAGPGRVRRRGSPGILQGPNVCGSRFHAYCCPGWRTF 75
Query: 56 NSKGVCEAT-CEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVN--T 112
+ C C C G C PN C C G +C + C C+N T
Sbjct: 76 PGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVS------RGSGCSVSCMNGGT 129
Query: 113 HGSYKCFCLSGH------MLMPDATCVNSRTCAMINCQYSCEDTEEGPQC-----LCPSS 161
C C G+ + D C N C N + +C GPQC P
Sbjct: 130 CRGASCLCQKGYTGTVCGQPICDRGCHNGGRCIGPN-RCACVYGFMGPQCERDYRTGPCF 188
Query: 162 GLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHI----------GFELQYI 211
G ++ P G + K +C C ++ C + GF
Sbjct: 189 G-QVGPEGCQH-QLTGLVCTKALC-----CATVGRAWGLPCELCPAQPHPCRRGFIPNIH 241
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
+G C D++EC C +C N GSF C+C G++
Sbjct: 242 TGA--CQDVDECQAVPGLCQG-GSCVNMVGSFHCRCPVGHR 279
Score = 43.9 bits (102), Expect = 4e-04
Identities = 29/103 (28%), Positives = 45/103 (43%), Gaps = 12/103 (11%)
Query: 44 GTKLACCYGWRRNSKG---VCEATCE---PGCKFGEC---VGPNKCRCFPGYTGKTC--- 91
G + +C G+ ++S+ V E C P C C +G +C C G+
Sbjct: 2548 GYRCSCPQGFTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGG 2607
Query: 92 SQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVN 134
Q+V+EC + PC + C NT G + C C G+ CV+
Sbjct: 2608 CQEVDECAGRRGPCSYSCANTPGGFLCGCPQGYFRAGQGHCVS 2650
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 144 bits (362), Expect = 3e-34
Identities = 76/212 (35%), Positives = 113/212 (53%), Gaps = 24/212 (11%)
Query: 69 CKFGECV---GPNKCRCFPGYTGKTCSQ---DVNECGMKPRPCQHRCVNTHGSYKCFCLS 122
C+ G+CV G +C C PGY Q D++EC + C +C N+ GSY+C C
Sbjct: 1211 CRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSE 1270
Query: 123 GHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQC---------LCPSSGLRLAPNGRDCL 173
G+ LMPD R+CA I+ + D +G QC LC G + + + C+
Sbjct: 1271 GYALMPDG-----RSCADIDECENNPDICDGGQCTNIPGEYRCLC-YDGFMASMDMKTCI 1324
Query: 174 DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHH 233
D++EC IC + C NT GS+ C C +G+ ++ G C D++EC + +H C H
Sbjct: 1325 DVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVK--KGTTGCTDVDECEIGAHNCDMH 1381
Query: 234 ANCFNTQGSFKCKCKQGYKGNGLRCSAIPENS 265
A+C N GSFKC C++G+ GNG++C + E S
Sbjct: 1382 ASCLNIPGSFKCSCREGWIGNGIKCIDLDECS 1413
Score = 130 bits (326), Expect = 4e-30
Identities = 71/208 (34%), Positives = 104/208 (50%), Gaps = 17/208 (8%)
Query: 65 CEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCF 119
C+ C E G +C C GY G++C+ D++EC P C +C N G Y+C
Sbjct: 1253 CDTQCTNSE--GSYECSCSEGYALMPDGRSCA-DIDECENNPDICDGGQCTNIPGEYRCL 1309
Query: 120 CLSGHMLMPDA-TCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
C G M D TC++ C + + C + CE+T+ C C G + C D+
Sbjct: 1310 CYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHC-QLGYSVKKGTTGCTDV 1368
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
DEC G C + C+N GS+ C C G +I CID++EC+ +H CS +A
Sbjct: 1369 DECEIGAHNCDMHASCLNIPGSFKCSCREG----WIGNGIKCIDLDECSNGTHQCSINAQ 1424
Query: 236 CFNTQGSFKCKCKQGYKGNGLRCSAIPE 263
C NT GS++C C +G+ G+G CS + E
Sbjct: 1425 CVNTPGSYRCACSEGFTGDGFTCSDVDE 1452
Score = 128 bits (322), Expect = 1e-29
Identities = 79/227 (34%), Positives = 111/227 (48%), Gaps = 24/227 (10%)
Query: 38 PGVCHYGTKLACCYG--WRRNSKGVCEATCEPG-CKFGECV---GPNKCRCFPGYT---- 87
PG Y K C +G + + + + E P C G+C+ G +C C GYT
Sbjct: 2428 PGTAQY--KKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINTMGSFRCFCKVGYTTDIS 2485
Query: 88 GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTC--AMINCQ 144
G +C D++EC P+PC + C NT GSY+C C G++L D TC + C NCQ
Sbjct: 2486 GTSCI-DLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQ 2544
Query: 145 YSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHI 204
+ C +T G C CP + C+D +EC S +C C NT GS+ C+C
Sbjct: 2545 FLCVNTLGGFTCKCPPG---FTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQR 2601
Query: 205 GFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
GF L + +C D++EC +H C H C N G ++C C QGY
Sbjct: 2602 GFSLD--ATGLNCEDVDECD-GNHRCQH--GCQNILGGYRCGCPQGY 2643
Score = 122 bits (307), Expect = 7e-28
Identities = 76/226 (33%), Positives = 111/226 (49%), Gaps = 21/226 (9%)
Query: 67 PG-CKFGECV---GPNKCRCFPGYTGKTC---SQDVNECGMKPRPCQHR--CVNTHGSYK 117
PG C G C+ G +C C G++ +D++EC CQ C+N+ GSY+
Sbjct: 1816 PGICANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYR 1875
Query: 118 CFCLSGHMLMPDATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLD 174
C C +G L P+ CV+ C I C + C D + QC+C +G + + + C+D
Sbjct: 1876 CECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCIC-HNGFKASQDQTMCMD 1934
Query: 175 IDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHA 234
+DEC N C NT GSY C C+ GFEL + + DC+DI+EC+ +
Sbjct: 1935 VDECERHPC---GNGTCKNTVGSYNCLCYPGFELTHNN---DCLDIDECSSFFGQVCRNG 1988
Query: 235 NCFNTQGSFKCKCKQGYK--GNGLRCSAIPENSVKEVLRAPGTIKD 278
CFN GSFKC C +GY+ +G C E +PGT ++
Sbjct: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQN 2034
Score = 111 bits (278), Expect = 2e-24
Identities = 78/233 (33%), Positives = 109/233 (46%), Gaps = 28/233 (12%)
Query: 48 ACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGY-------TGKTCSQDVNECGM 100
ACC CE +PG K E + P G+ TG+ +D+NEC
Sbjct: 1024 ACCCAVGAAWGTECEECPKPGTKEYETLCPRGA----GFANRGDVLTGRPFYKDINECKA 1079
Query: 101 KPRPCQH-RCVNTHGSYKCFCLSGHML-MPDATCVNSRTCAM---INCQYSCEDTEEGPQ 155
P C + +C NT GS+KC C SG L M + C + C + + C +T +
Sbjct: 1080 FPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFE 1139
Query: 156 CLC---PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYIS 212
C C SG + N C+DIDEC ++C CVNT GS+ C C +G EL
Sbjct: 1140 CECFEGYESGFMMMKN---CMDIDECERNPLLCR-GGTCVNTEGSFQCDCPLGHELS--P 1193
Query: 213 GRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLR--CSAIPE 263
R DC+DINEC++ + C + C N G+++C C GY+ R C+ I E
Sbjct: 1194 SREDCVDINECSLSDNLC-RNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDE 1245
Score = 105 bits (262), Expect = 1e-22
Identities = 86/299 (28%), Positives = 132/299 (44%), Gaps = 28/299 (9%)
Query: 64 TCEPGCKFGECV---GPNKCRCFPGYTGK-TCSQDVNECGMKPRPCQHR--CVNTHGSYK 117
T + C+F CV G C+C PG+T T D NECG +P C + C NT GS+
Sbjct: 2538 TKQHNCQF-LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFS 2596
Query: 118 CFCLSGHMLMPDATCVNSRTCAMIN----CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL 173
C C G L DAT +N + CQ+ C++ G +C CP ++ C+
Sbjct: 2597 CECQRGFSL--DATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHY-QWNQCV 2653
Query: 174 DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHH 233
D +EC++ + C NT GSY C C GF S C D+NEC+ + C++
Sbjct: 2654 DENECSNPNACG--SASCYNTLGSYKCACPSGFSFDQFSSA--CHDVNECSSSKNPCNY- 2708
Query: 234 ANCFNTQGSFKCKCKQGY--KGNGLRCSAIPEN-----SVKEVLRAPGTIKDRIKKLLAH 286
C NT+G + C C GY G G S + N S+ + +
Sbjct: 2709 -GCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKI 2767
Query: 287 KNSMKKKAKIKNVTPEPTRTPTPKVNLQPFNYEEIVSRGGN-SHGGKKGNEEKMKEGLE 344
KK ++ K EP T +++L+ + + V+ N SH G K + +++ ++
Sbjct: 2768 NGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMKFNLSHLGSKEHILELRPAIQ 2826
Score = 104 bits (259), Expect = 2e-22
Identities = 66/185 (35%), Positives = 94/185 (50%), Gaps = 11/185 (5%)
Query: 84 PGYTGKTC-SQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMI 141
P TG T +Q ++ C C + RC+ T SY+C C G+ + C++ C
Sbjct: 483 PIITGLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSN 542
Query: 142 NCQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYC 200
C C +T C C +G + P + C+DIDEC V+C N RCVNT GS+ C
Sbjct: 543 PCTNGDCVNTPGSYYCKC-HAGFQRTPTKQACIDIDECIQNGVLCK-NGRCVNTDGSFQC 600
Query: 201 KCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY--KGNGLRC 258
C+ GFEL + +C+D +ECT ++ C + C N GSFKC CK G+ NG C
Sbjct: 601 ICNAGFEL--TTDGKNCVDHDECT-TTNMCL-NGMCINEDGSFKCICKPGFVLAPNGRYC 656
Query: 259 SAIPE 263
+ + E
Sbjct: 657 TDVDE 661
Score = 103 bits (256), Expect = 5e-22
Identities = 86/277 (31%), Positives = 123/277 (44%), Gaps = 44/277 (15%)
Query: 38 PGVCHYGT--------KLACCYGWRRNSKGV-CEAT--CEPG--CKFGEC---VGPNKCR 81
PG+C G + C G+ + GV C T C G C G C +G +C
Sbjct: 2179 PGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTNVIGSFECN 2238
Query: 82 CFPGYTGKTCS--QDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTC 138
C G+ +D+NEC P C RC+NT GSY+C C G+ L D C + C
Sbjct: 2239 CNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDEC 2298
Query: 139 A--MINCQ---YSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVN 193
A + +C+ C++ C+CP G+ P+G C+D +EC + IC N RCVN
Sbjct: 2299 AEGLHDCESRGMMCKNLIGTFMCICP-PGMARRPDGEGCVDENECRTKPGICE-NGRCVN 2356
Query: 194 TFGSYYCKCHIGFELQYISGRYDCIDINE--CTMD--SHTCSHHANCFNTQGSFKCKCKQ 249
GSY C+C+ GF Q S +C+D + C + C ++ N +C C
Sbjct: 2357 IIGSYRCECNEGF--QSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSEC-CCD 2413
Query: 250 GYKGNGLRCSAIPENSVKEVLRAPGTIKDRIKKLLAH 286
G +G G +C P PGT + KK+ H
Sbjct: 2414 GGRGWGHQCELCP---------LPGTA--QYKKICPH 2439
Score = 95.1 bits (235), Expect = 1e-19
Identities = 69/209 (33%), Positives = 102/209 (48%), Gaps = 24/209 (11%)
Query: 27 RHHGLLASARQ--PGVCHYGTKLACCYGWRRNSKGVC----EATCEPGCKFGECV---GP 77
+HH L + P V Y + C G+++++ G C E T P C G+CV G
Sbjct: 499 KHHANLCLNGRCIPTVSSY--RCECNMGYKQDANGDCIDVDECTSNP-CTNGDCVNTPGS 555
Query: 78 NKCRCFPGYTGKTCSQ---DVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDA-TC 132
C+C G+ Q D++EC C++ RCVNT GS++C C +G L D C
Sbjct: 556 YYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNC 615
Query: 133 VNSRTCAMINCQYS--CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRR 190
V+ C N + C + + +C+C G LAPNGR C D+DEC + + N
Sbjct: 616 VDHDECTTTNMCLNGMCINEDGSFKCIC-KPGFVLAPNGRYCTDVDECQTPGIC--MNGH 672
Query: 191 CVNTFGSYYCKCHIGFELQYISGRYDCID 219
C+N+ GS+ C C G + + GR C+D
Sbjct: 673 CINSEGSFRCDCPPGLAVG-MDGRV-CVD 699
Score = 94.0 bits (232), Expect = 3e-19
Identities = 69/210 (32%), Positives = 91/210 (43%), Gaps = 25/210 (11%)
Query: 69 CKFGECV---GPNKCRCFPGYT---GKTCSQDVNECGMKPRPCQHR--CVNTHGSYKCFC 120
C FGEC G C C GY+ G T DV+EC + C C+N GS+KC C
Sbjct: 1336 CMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSC 1395
Query: 121 LSGHM-----LMPDATCVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
G + + C N IN Q C +T +C C +G C D+
Sbjct: 1396 REGWIGNGIKCIDLDECSNGTHQCSINAQ--CVNTPGSYRCACSEG---FTGDGFTCSDV 1450
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
DECA +C N +C+N G+Y C+C +GF S C DI+EC+ +
Sbjct: 1451 DECAENINLCE-NGQCLNVPGAYRCECEMGF--TPASDSRSCQDIDECSFQN--ICVFGT 1505
Query: 236 CFNTQGSFKCKCKQGYK--GNGLRCSAIPE 263
C N G F C C GY+ G C+ I E
Sbjct: 1506 CNNLPGMFHCICDDGYELDRTGGNCTDIDE 1535
Score = 92.8 bits (229), Expect = 7e-19
Identities = 83/259 (32%), Positives = 111/259 (42%), Gaps = 33/259 (12%)
Query: 19 GFGNAASARHHGLLASARQPGVCHYGT--------KLACCYGWRRNSKG-VC-----EAT 64
GF A + R+ + + PG+C G + C G G VC +T
Sbjct: 646 GFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRST 705
Query: 65 CEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGH 124
C G K G CV P FPG K+ N PCQ + C SG
Sbjct: 706 CYGGIKKGVCVRP-----FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGV 760
Query: 125 MLMPDATCVNSRTCAM---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASG 181
+ D +N CA+ I CE+ +C C +SG +GR+C+DIDEC
Sbjct: 761 GITVDGRDINE--CALDPDICANGICENLRGSYRCNC-NSGYEPDASGRNCIDIDECLVN 817
Query: 182 KVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQG 241
+++C N C NT GSY C C G+ + + C DINEC +S+ C + A C N G
Sbjct: 818 RLLCD-NGLCRNTPGSYSCTCPPGYVFR--TETETCEDINEC--ESNPCVNGA-CRNNLG 871
Query: 242 SFKCKCKQGYK--GNGLRC 258
SF C+C G K GL C
Sbjct: 872 SFNCECSPGSKLSSTGLIC 890
Score = 87.8 bits (216), Expect = 2e-17
Identities = 65/205 (31%), Positives = 89/205 (43%), Gaps = 31/205 (15%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCF 119
VCE C+ G G C+GPN+C C G+TG C +D + PC + N
Sbjct: 179 VCENGCQNG---GRCIGPNRCACVYGFTGPQCERD-----YRTGPCFTQVNNQ------M 224
Query: 120 CLSGHMLMPDATCVNSRTCAMINCQYS--CEDTEEGPQCLCPSSGLRLAPNGRD--CLDI 175
C + C + CA I + CE PQ PN R C D+
Sbjct: 225 CQG---QLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQ----PCRRGFIPNIRTGACQDV 277
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
DEC + IC C+NT GS+ C+C G + + + C DI+EC++ C
Sbjct: 278 DECQAIPGIC-QGGNCINTVGSFECRCPAGHKQSETTQK--CEDIDECSIIPGIC-ETGE 333
Query: 236 CFNTQGSFKCKCKQGY--KGNGLRC 258
C NT GS+ C C +GY +G RC
Sbjct: 334 CSNTVGSYFCVCPRGYVTSTDGSRC 358
Score = 87.8 bits (216), Expect = 2e-17
Identities = 69/230 (30%), Positives = 95/230 (41%), Gaps = 48/230 (20%)
Query: 67 PG-CKFGECV---GPNKCRCFPGY----TGKTCSQDVNECGMKPRPC-QHRCVNTHGSYK 117
PG C+ G C+ G +C C GY + C +D++EC P C C NT G+Y
Sbjct: 1658 PGLCQGGNCINTFGSFQCECPQGYYLSEDTRIC-EDIDECFAHPGVCGPGTCYNTLGNYT 1716
Query: 118 CFC-------LSGHMLMP-----------DATCVN----SRTCAMINCQYSCEDTEEGPQ 155
C C GH M TC N + T M C Y+ P
Sbjct: 1717 CICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPC 1776
Query: 156 CLCPS-------------SGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKC 202
CP+ G + +DIDEC IC N C+N GS+ C+C
Sbjct: 1777 EPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICA-NGVCINQIGSFRCEC 1835
Query: 203 HIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
GF Y C DI+EC+ + C +A+C N+ GS++C+C G+K
Sbjct: 1836 PTGF--SYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFK 1883
Score = 85.9 bits (211), Expect = 9e-17
Identities = 76/234 (32%), Positives = 101/234 (43%), Gaps = 56/234 (23%)
Query: 88 GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQ-- 144
G TC +DVNEC + P C + RCVN+ GS+ C C G L D T R C I +
Sbjct: 950 GVTC-EDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTL--DGT---GRVCLDIRMEQC 1003
Query: 145 YSCEDTEE----------------------GPQCL-CPSSGLR----LAPNGR------D 171
Y D +E G +C CP G + L P G D
Sbjct: 1004 YLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGD 1063
Query: 172 CL-------DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECT 224
L DI+EC + +C Y + C NT GS+ C+C+ GF L +C DI+EC
Sbjct: 1064 VLTGRPFYKDINECKAFPGMCTYGK-CRNTIGSFKCRCNSGFALDM--EERNCTDIDECR 1120
Query: 225 MDSHTCSHHANCFNTQGSFKCKCKQGYKGNGL---RCSAIPENSVKEVLRAPGT 275
+ C C NT GSF+C+C +GY+ + C I E +L GT
Sbjct: 1121 ISPDLCGSGI-CVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGT 1173
Score = 85.1 bits (209), Expect = 2e-16
Identities = 74/245 (30%), Positives = 97/245 (39%), Gaps = 57/245 (23%)
Query: 69 CKFGEC---VGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFC 120
C+ G C +G KC C GY GK C D NEC P C C N GS++C C
Sbjct: 1985 CRNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCIC 2043
Query: 121 LSGHMLMPDATCVNSRTC---AMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
G+ + + C++ C I SC +T G QCLCP G L+ NGR C D +
Sbjct: 2044 PPGYEVKSE-NCIDINECDEDPNICLFGSCTNTPGGFQCLCPP-GFVLSDNGRRCFDTRQ 2101
Query: 178 C------ASGKVICPYNRRCVNTFGSYYCKC---------------------HIGFE--L 208
+GK P F + KC + F+
Sbjct: 2102 SFCFTNFENGKCSVP------KAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLC 2155
Query: 209 QYISGRYDCI-----DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAI 261
Y G + D+NEC CS+ C NT GSF+C+C GY G+RC
Sbjct: 2156 PYGHGTVPSLHDTREDVNECLESPGICSN-GQCINTDGSFRCECPMGYNLDYTGVRCVDT 2214
Query: 262 PENSV 266
E S+
Sbjct: 2215 DECSI 2219
Score = 75.5 bits (184), Expect = 1e-13
Identities = 73/246 (29%), Positives = 94/246 (38%), Gaps = 58/246 (23%)
Query: 55 RNSKGVCEATCEPGCKFGEC---VGPNKCRCFPGY----TGKTCSQDVNECGMKPRPCQH 107
R+ + + E + + C FG C G C C GY TG C+ D++EC
Sbjct: 1487 RSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCT-DIDECADPINCVNG 1545
Query: 108 RCVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMINC----------QYSCEDTEEG--- 153
CVNT G Y+C C L P CV++R NC SC +TE G
Sbjct: 1546 LCVNTPGRYECNCPPDFQLNPTGVGCVDNRVG---NCYLKFGPRGDGSLSC-NTEIGVGV 1601
Query: 154 --PQC-------------------------LCPSS-GLRLAPNGRDCLDIDECASGKVIC 185
C LCP G R P DIDEC +C
Sbjct: 1602 SRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLC 1661
Query: 186 PYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC 245
C+NTFGS+ C+C G+ L C DI+EC C C+NT G++ C
Sbjct: 1662 Q-GGNCINTFGSFQCECPQGYYLS--EDTRICEDIDECFAHPGVCG-PGTCYNTLGNYTC 1717
Query: 246 KCKQGY 251
C Y
Sbjct: 1718 ICPPEY 1723
Score = 64.3 bits (155), Expect = 3e-10
Identities = 62/224 (27%), Positives = 85/224 (37%), Gaps = 43/224 (19%)
Query: 69 CKFGECV---GPNKCRCFPGYTGKTCS---QDVNECGMKPRPCQHRCVNTHGSYKCFCLS 122
C+ G+C+ G +C C G+T + S QD++EC + C N G + C C
Sbjct: 1460 CENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDD 1519
Query: 123 GHML-MPDATCVNSRTCA-MINCQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLD--IDE 177
G+ L C + CA INC C +T +C CP +L P G C+D +
Sbjct: 1520 GYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCPPD-FQLNPTGVGCVDNRVGN 1578
Query: 178 C-------ASGKVICPYN-------RRCVNTFGS----------------YYCKCHIGFE 207
C G + C C + G YY C G
Sbjct: 1579 CYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEG 1638
Query: 208 LQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
+ DI+EC C NC NT GSF+C+C QGY
Sbjct: 1639 FRPNPITIILEDIDECQELPGLCQG-GNCINTFGSFQCECPQGY 1681
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 142 bits (357), Expect = 1e-33
Identities = 87/229 (37%), Positives = 115/229 (50%), Gaps = 19/229 (8%)
Query: 45 TKLACCYGWRR--NSKGVCEATCEPGCKF--GECV--GPNKCRCFPGYTGKTCSQDVNEC 98
T L CC GW + + +G A C F G CV C C PG+ G C DV+EC
Sbjct: 106 TVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDEC 165
Query: 99 GMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN--CQYSC-EDTEEGP 154
CQHRCVNT GSY C C G L D+ TC+ +CA+ N CQ+ C + T
Sbjct: 166 RTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRH 225
Query: 155 QCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGR 214
+C C G +L +GR C+ CA+ C + RC G C+CH+G++L +
Sbjct: 226 RCQC-RPGFQLQEDGRHCVRRSPCANRNGSCMH--RCQVVRGLARCECHVGYQL--AADG 280
Query: 215 YDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAI 261
C D++EC C+H C NTQGSFKC C GY+ +G +C I
Sbjct: 281 KACEDVDECAAGLAQCAH--GCLNTQGSFKCVCHAGYELGADGRQCYRI 327
Score = 125 bits (313), Expect = 1e-28
Identities = 77/225 (34%), Positives = 101/225 (44%), Gaps = 29/225 (12%)
Query: 56 NSKGVCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVN 111
N G C C+ G +C C GY GK C +DV+EC C H C+N
Sbjct: 250 NRNGSCMHRCQV------VRGLARCECHVGYQLAADGKAC-EDVDECAAGLAQCAHGCLN 302
Query: 112 THGSYKCFCLSGHMLMPDAT--------CVNSRTCAMINCQYSCEDTEEGPQCLCPSSGL 163
T GS+KC C +G+ L D VNS C + C T GP C CP G
Sbjct: 303 TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPR-GY 361
Query: 164 RLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC 223
L + R C+D+D+CA + C N G Y C C+ G+ L + C D++EC
Sbjct: 362 ELDTDQRTCIDVDDCADSPCC---QQVCTNNPGGYECGCYAGYRLS--ADGCGCEDVDEC 416
Query: 224 TMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLR--CSAIPENSV 266
C HH C N GSF+C C+ GY+ + R CS + E V
Sbjct: 417 ASSRGGCEHH--CTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMV 459
Score = 63.9 bits (154), Expect = 4e-10
Identities = 49/151 (32%), Positives = 64/151 (42%), Gaps = 17/151 (11%)
Query: 40 VCHYGTKLAC----CYGWRRNSKGVCEAT---CEPGCKFGECVGPNKCRCFPGY---TGK 89
VCH G +L CY CEA C GC GP C C GY T +
Sbjct: 310 VCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSA-GP-LCTCPRGYELDTDQ 367
Query: 90 TCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMI--NCQYS 146
DV++C P CQ C N G Y+C C +G+ L D C + CA C++
Sbjct: 368 RTCIDVDDCADSPC-CQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSRGGCEHH 426
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
C + QC C +G RL + R C ++E
Sbjct: 427 CTNLAGSFQCSC-EAGYRLHEDRRGCSPLEE 456
Score = 55.5 bits (132), Expect = 1e-07
Identities = 59/208 (28%), Positives = 80/208 (38%), Gaps = 39/208 (18%)
Query: 34 SARQPGVCHYGT-KLACCYGWRRNSKGVCEATCEPGCKFG-----ECVGPNK-------- 79
S R G+CH +C GW CE C PG ++G EC N
Sbjct: 1306 SCRNGGLCHASNGSCSCGLGWTGRH---CELACPPG-RYGAACHLECSCHNNSTCEPATG 1361
Query: 80 -CRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVN--SR 136
CRC PG+ G+ C G CQ C HG+ C +SG L P + R
Sbjct: 1362 TCRCGPGFYGQACEHPCPP-GFHGAGCQGLCWCQHGA-PCDPISGRCLCPAGFHGHFCER 1419
Query: 137 TCAM----INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDID-ECASGKVICPYNRRC 191
C C C D + G C P +GL L P GR + +C G+ + C
Sbjct: 1420 GCEPGSFGEGCHQRC-DCDGGAPC-DPVTGLCLCPPGRSGATCNLDCRRGQ----FGPSC 1473
Query: 192 VNTFGSYYCKCHIGFELQYISGRYDCID 219
+ +C C G + +SG+ C+D
Sbjct: 1474 -----TLHCDCGGGADCDPVSGQCHCVD 1496
Score = 50.8 bits (120), Expect = 3e-06
Identities = 74/282 (26%), Positives = 95/282 (33%), Gaps = 78/282 (27%)
Query: 18 GGFGNAASARHHGLLASARQPGVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGE---- 73
G FG A + R S CH+ T C S CE C PG FGE
Sbjct: 1122 GWFGEACAQR-----CSCPPGAACHHVTGACRCPPGFTGSG--CEQACPPG-SFGEDCAQ 1173
Query: 74 ---CVGPNK--------CRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLS 122
C G N C C GY G +C Q P C+ C +G C +
Sbjct: 1174 MCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPG-CEQLCGCLNGG-SCDAAT 1231
Query: 123 GHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQC--LC---------PSSGLRLAPNGRD 171
G P +C +C GP C +C P +G L P GR
Sbjct: 1232 GACRCPTGFLGT-------DCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRA 1284
Query: 172 CLDIDECASGKVICPYNR---------------RCVNTFGSYYCKCHIGF-----ELQYI 211
+ C G CP NR C + GS C C +G+ EL
Sbjct: 1285 GV---RCERG---CPQNRFGVGCEHTCSCRNGGLCHASNGS--CSCGLGWTGRHCELACP 1336
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKG 253
GRY EC+ C +++ C G+ C+C G+ G
Sbjct: 1337 PGRYGAACHLECS-----CHNNSTCEPATGT--CRCGPGFYG 1371
Score = 45.4 bits (106), Expect = 1e-04
Identities = 61/237 (25%), Positives = 79/237 (33%), Gaps = 58/237 (24%)
Query: 61 CEATCEPGCKFGECVG-PNKCRCFPGYTGKTCSQDVNE------CGMKPRPCQH--RCVN 111
C ++C C C G +CRC PG TG+ C D E C CQH RC
Sbjct: 740 CSSSCS--CGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCDP 797
Query: 112 THGSYKCFCLSGHM----------------LMPDATCVNSRTC-------------AMIN 142
G+ C CL G + +C N C +
Sbjct: 798 ETGA--CLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFS 855
Query: 143 CQYSCEDTEEGPQCLCPSS-----GLRLAPNGRDCLDIDECASGKVICPYNRRC-VNTFG 196
CQ +C+ GP C P + G A +G CL C +G V ++C FG
Sbjct: 856 CQRACDTGHWGPDCSHPCNCSAGHGSCDAISGL-CL----CEAGYVGPRCEQQCPQGHFG 910
Query: 197 ---SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQG 250
C+C G ++SG C T H C A F C C G
Sbjct: 911 PGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACP--AGFFGLDCRSACNCTAG 965
Score = 42.4 bits (98), Expect = 0.001
Identities = 61/267 (22%), Positives = 84/267 (31%), Gaps = 64/267 (23%)
Query: 42 HYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMK 101
H C GWR CE C G +C + C C G C C
Sbjct: 927 HVSGACTCPAGWRGT---FCEHACPAGFFGLDC--RSACNCT---AGAACDAVNGSCLCP 978
Query: 102 PRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCL--CP 159
RC T ++ GH C N +C ++ Q C GP CL CP
Sbjct: 979 AGRRGPRCAETCPAHTY----GHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACP 1034
Query: 160 S----------------------SGLRLAPNG-------RDCLDID---------ECASG 181
+ SG P G ++CL D C +G
Sbjct: 1035 AGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNG 1094
Query: 182 KVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQG 241
+ P+ RC+ G KC + + G + E +C A C + G
Sbjct: 1095 GLCDPHTGRCLCPAGWTGDKC----QSPCLRGWF-----GEACAQRCSCPPGAACHHVTG 1145
Query: 242 SFKCKCKQGYKGNGLRCSAIPENSVKE 268
+ C+C G+ G+G A P S E
Sbjct: 1146 A--CRCPPGFTGSGCE-QACPPGSFGE 1169
Score = 41.2 bits (95), Expect = 0.003
Identities = 53/232 (22%), Positives = 75/232 (32%), Gaps = 49/232 (21%)
Query: 36 RQPGVCHYGTK-LACCYGWRRNSKGVCEATCEP-----GCKF-------GECVG-PNKCR 81
R G C G C GW + +C TC P C F G C CR
Sbjct: 528 RNGGTCLLGLDGCDCPEGW---TGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACR 584
Query: 82 CFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMI 141
C PG +G C +D G + C+ +C N +C L G C+
Sbjct: 585 CPPGVSGTNC-EDGCPKGYYGKHCRKKC-NCANRGRCHRLYG-------ACLCDPGLYGR 635
Query: 142 NCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCK 201
C +C GP C +EC + + P+ + C GS C
Sbjct: 636 FCHLTCPPWAFGPGC------------------SEEC---QCVQPHTQSCDKRDGS--CS 672
Query: 202 CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKG 253
C GF + + + TC C + G +C G++G
Sbjct: 673 CKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPAGFQG 724
Score = 40.0 bits (92), Expect = 0.006
Identities = 59/235 (25%), Positives = 79/235 (33%), Gaps = 61/235 (25%)
Query: 61 CEATCE-----PGCKFGECVGP---------NKC--RCFPGYTGKTCSQDVNECGMKPRP 104
C+A CE PGC + C P +C RC G+ G+ C Q EC P
Sbjct: 682 CQAECELGYFGPGC-WQACTCPVGVACDSVSGECGKRCPAGFQGEDCGQ---EC-----P 732
Query: 105 CQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQC--LCPS-- 160
VN S C H + C RT +C+ C + G C +CP+
Sbjct: 733 VGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGE--DCEADCPEGRWGLGCQEICPACQ 790
Query: 161 SGLRLAPNGRDCLDI---------DECASG--------KVICPYNRRCVNTFGSYYCKCH 203
R P CL + D C +G + C + C G +C C
Sbjct: 791 HAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATG--HCSCA 848
Query: 204 IGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFK-----CKCKQGYKG 253
G+ + C + CSH NC GS C C+ GY G
Sbjct: 849 PGWT------GFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVG 897
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 136 bits (343), Expect = 4e-32
Identities = 86/259 (33%), Positives = 119/259 (45%), Gaps = 52/259 (20%)
Query: 47 LACCYGWRRNSKGVCEATCEPG----------------------CKFGECV---GPNKCR 81
L C G N++G C PG C G CV G +C
Sbjct: 1122 LLCRGGVCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCA 1181
Query: 82 CFPGYTG---KTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTC 138
C PGY + D++EC + C+ C N+ GSY+C C G LMPD R+C
Sbjct: 1182 CNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPD-----QRSC 1236
Query: 139 AMINCQYSCEDTE---EGPQC---------LCPSSGLRLAPNGRDCLDIDECASGKVICP 186
I+ CED +G QC LC G + + + C+D++EC IC
Sbjct: 1237 TDID---ECEDNPNICDGGQCTNIPGEYRCLC-YDGFMASEDMKTCVDVNECDLNPNIC- 1291
Query: 187 YNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCK 246
+ C NT GS+ C C +G+ + G+ C DINEC + +H C HA C NT GSFKC
Sbjct: 1292 LSGTCENTKGSFICHCDMGYSGK--KGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCS 1349
Query: 247 CKQGYKGNGLRCSAIPENS 265
C G+ G+G++C+ + E S
Sbjct: 1350 CSPGWIGDGIKCTDLDECS 1368
Score = 131 bits (330), Expect = 1e-30
Identities = 79/226 (34%), Positives = 109/226 (48%), Gaps = 24/226 (10%)
Query: 65 CEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCF 119
CE C E G +C C PG+ ++C+ D++EC P C +C N G Y+C
Sbjct: 1208 CETFCTNSE--GSYECSCQPGFALMPDQRSCT-DIDECEDNPNICDGGQCTNIPGEYRCL 1264
Query: 120 CLSGHMLMPDA-TCVNSRTCAM---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
C G M D TCV+ C + I +CE+T+ C C G C DI
Sbjct: 1265 CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHC-DMGYSGKKGKTGCTDI 1323
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
+EC G C + C NT GS+ C C G +I C D++EC+ +H CS HA+
Sbjct: 1324 NECEIGAHNCGKHAVCTNTAGSFKCSCSPG----WIGDGIKCTDLDECSNGTHMCSQHAD 1379
Query: 236 CFNTQGSFKCKCKQGYKGNGLRCSAIPENSVK-------EVLRAPG 274
C NT GS++C CK+GY G+G C+ + E S + L APG
Sbjct: 1380 CKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPG 1425
Score = 130 bits (328), Expect = 2e-30
Identities = 92/260 (35%), Positives = 127/260 (48%), Gaps = 27/260 (10%)
Query: 38 PGVCHYGT--------KLACCYGWRRNSKG-VCEATCE----PGC-KFGECV---GPNKC 80
PGVC G + C G+ N K VCE E P C + EC+ G +C
Sbjct: 1774 PGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRC 1833
Query: 81 RCFPGYTGKTCSQ--DVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDAT-CVNSR 136
C PGY + Q D NEC P C H +C++T GS+ C C +G D T C++
Sbjct: 1834 DCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLDIN 1893
Query: 137 TCAMINC-QYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTF 195
C C +C +T C C + G L+ N DC+D+DECASG N +C+NT
Sbjct: 1894 ECERDACGNGTCRNTIGSFNCRC-NHGFILSHNN-DCIDVDECASGNGNLCRNGQCINTV 1951
Query: 196 GSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNG 255
GS+ C+C+ G+E+ GR C+DINEC ++ C+ C N GS++C C GY
Sbjct: 1952 GSFQCQCNEGYEVA-PDGR-TCVDINECLLEPRKCA-PGTCQNLDGSYRCICPPGYSLQN 2008
Query: 256 LRCSAIPENSVKEVLRAPGT 275
+C I E + + A GT
Sbjct: 2009 EKCEDIDECVEEPEICALGT 2028
Score = 129 bits (325), Expect = 5e-30
Identities = 74/193 (38%), Positives = 96/193 (49%), Gaps = 19/193 (9%)
Query: 69 CKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCL 121
C+ GECV G C C GYT G +C D+NEC P+PC C NT GSY+C C
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDITGTSCV-DLNECNQAPKPCNFICKNTEGSYQCSCP 2471
Query: 122 SGHMLMPDA-TCVNSRTCA--MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDEC 178
G++L D +C + CA NCQ+ C +T G C CP + C+D +EC
Sbjct: 2472 KGYILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPG---FTQHHTSCIDNNEC 2528
Query: 179 ASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFN 238
S +C C NT GS+ C+C GF L C D++EC +H C H C N
Sbjct: 2529 TSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGS--SCEDVDECE-GNHRCQH--GCQN 2583
Query: 239 TQGSFKCKCKQGY 251
G ++C C QGY
Sbjct: 2584 IIGGYRCSCPQGY 2596
Score = 105 bits (263), Expect = 8e-23
Identities = 70/201 (34%), Positives = 93/201 (46%), Gaps = 24/201 (11%)
Query: 63 ATCEPGCKF--GECVGPNKCRCFPGYT--------GKTCSQDVNECGMKPRPCQHRCVNT 112
AT + C+F +G C+C PG+T C+ D+N CG K C NT
Sbjct: 2490 ATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGI-----CQNT 2544
Query: 113 HGSYKCFCLSGHML-MPDATCVNSRTC-AMINCQYSCEDTEEGPQCLCPSSGLRLAPNGR 170
GS+ C C G L ++C + C CQ+ C++ G +C CP L+
Sbjct: 2545 PGSFTCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHY-QWN 2603
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
C+D +EC S IC C NT GSY C C GF+ + SG C DINEC C
Sbjct: 2604 QCVDENECLSAH-ICG-GASCHNTLGSYKCMCPAGFQYEQFSG--GCQDINECGSAQAPC 2659
Query: 231 SHHANCFNTQGSFKCKCKQGY 251
S+ C NT+G + C C GY
Sbjct: 2660 SY--GCSNTEGGYLCGCPPGY 2678
Score = 102 bits (255), Expect = 7e-22
Identities = 85/251 (33%), Positives = 113/251 (45%), Gaps = 50/251 (19%)
Query: 55 RNSKGVCEATCEPGCKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQH 107
+N + + E + C G C+ G KC C PG+ G+ C +D+NEC
Sbjct: 568 KNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYC-KDINECETPGICMNG 626
Query: 108 RCVNTHGSYKCFCLSGHMLMPDA-TCVNSR---TC---------------AMINCQYSCE 148
RCVNT GSY+C C G + D CV++ TC A+ + C
Sbjct: 627 RCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCA 686
Query: 149 DTEE--GPQCL-CP-----------SSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNT 194
TE G C CP SSG + G DI+ECA ICP N C N
Sbjct: 687 STEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGS---DINECALDPDICP-NGICENL 742
Query: 195 FGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQG--YK 252
G+Y C C+ G+E+ S +C+DINEC ++S C + C NT GSF C C +G YK
Sbjct: 743 RGTYKCICNSGYEVD--STGKNCVDINECVLNSLLCD-NGQCRNTPGSFVCTCPKGFIYK 799
Query: 253 GNGLRCSAIPE 263
+ C I E
Sbjct: 800 PDLKTCEDIDE 810
Score = 102 bits (255), Expect = 7e-22
Identities = 70/190 (36%), Positives = 94/190 (49%), Gaps = 19/190 (10%)
Query: 88 GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML-MPDATCVNSRTCAM---IN 142
GK +D+NEC M P C H +C NT GS+KC C SG L + C + C + +
Sbjct: 1022 GKPFFKDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLC 1081
Query: 143 CQYSCEDTEEGPQCLCPS---SGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYY 199
+ C +T +C C SG + N C+DIDEC ++C C NT GSY
Sbjct: 1082 GRGQCVNTPGDFECKCDEGYESGFMMMKN---CMDIDECQRDPLLC-RGGVCHNTEGSYR 1137
Query: 200 CKCHIGFELQ-YISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKG--NGL 256
C+C G +L IS CIDINEC + +H C + C N G ++C C GY + L
Sbjct: 1138 CECPPGHQLSPNISA---CIDINECELSAHLCP-NGRCVNLIGKYQCACNPGYHSTPDRL 1193
Query: 257 RCSAIPENSV 266
C I E S+
Sbjct: 1194 FCVDIDECSI 1203
Score = 100 bits (250), Expect = 3e-21
Identities = 78/254 (30%), Positives = 117/254 (46%), Gaps = 33/254 (12%)
Query: 36 RQPGVCHYGT--------KLACCYGW-RRNSKGVCEATCEPG--CKFGEC---VGPNKCR 81
++P VC +G + C +G+ ++ V C G C G C +G +C
Sbjct: 2132 KEPDVCKHGQCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECT 2191
Query: 82 CFPGYTG---KTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRT 137
C G+ TC +D+NEC P C RCVNT+GSY+C C G++L D C +
Sbjct: 2192 CEEGFEPGPMMTC-EDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRMCKDEDE 2250
Query: 138 C--AMINC---QYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCV 192
C +C Q C++ C+C G + P+G C+D +EC + IC N RC+
Sbjct: 2251 CEEGKHDCTEKQMECKNLIGTYMCIC-GPGYQRRPDGEGCVDENECQTKPGICE-NGRCL 2308
Query: 193 NTFGSYYCKCHIGFELQYISGRYDCIDINE--CTMD--SHTCSHHANCFNTQGSFKCKCK 248
NT GSY C+C+ GF + +C+D E C + + C ++ N +C C
Sbjct: 2309 NTRGSYTCECNDGFTAS--PNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSEC-CC 2365
Query: 249 QGYKGNGLRCSAIP 262
G +G G C P
Sbjct: 2366 DGGRGWGPHCEICP 2379
Score = 98.6 bits (244), Expect = 1e-20
Identities = 68/196 (34%), Positives = 93/196 (47%), Gaps = 14/196 (7%)
Query: 76 GPNKCRCFPGYTGKTCS-QDVNECGMKPRPC-QHR-CVNTHGSYKCFCLSGHMLMPDATC 132
G KC C PG+ G D++EC C QH C NT GSY+C C G+ TC
Sbjct: 1344 GSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYT-GDGFTC 1402
Query: 133 VNSRTCAM---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNR 189
+ C+ + C + G +C C G + +G+ C DIDEC+ IC +
Sbjct: 1403 TDLDECSENLNLCGNGQCLNAPGGYRCEC-DMGFVPSADGKACEDIDECSLPN-ICVFGT 1460
Query: 190 RCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
C N G + C+C IG+EL G +C D+NEC +D TC NC NT GS+ C C
Sbjct: 1461 -CHNLPGLFRCECEIGYELDRSGG--NCTDVNEC-LDPTTCIS-GNCVNTPGSYICDCPP 1515
Query: 250 GYKGNGLRCSAIPENS 265
++ N R + S
Sbjct: 1516 DFELNPTRVGCVDTRS 1531
Score = 93.6 bits (231), Expect = 4e-19
Identities = 69/214 (32%), Positives = 97/214 (45%), Gaps = 50/214 (23%)
Query: 82 CFPGYT---GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDAT---CVN 134
C GY+ G C +D++EC + P C++ CVNT GS+KC C SG L DAT C++
Sbjct: 896 CGKGYSRIKGTQC-EDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTL--DATGRICLD 952
Query: 135 SRT-------------------------CAMINCQYSCEDTEEGP-------QCLCPSS- 161
R C + + E+ EE P + LCP
Sbjct: 953 IRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGP 1012
Query: 162 --GLRLAPNGRDCL-DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCI 218
+ NG+ DI+EC +C + + C NT GS+ C+C GF L S +C
Sbjct: 1013 GFATKEITNGKPFFKDINECKMIPSLCTHGK-CRNTIGSFKCRCDSGFALD--SEERNCT 1069
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
DI+EC + C C NT G F+CKC +GY+
Sbjct: 1070 DIDECRISPDLCGR-GQCVNTPGDFECKCDEGYE 1102
Score = 91.3 bits (225), Expect = 2e-18
Identities = 89/288 (30%), Positives = 115/288 (39%), Gaps = 88/288 (30%)
Query: 55 RNSKGVC--EATCEPG---C--KFGEC---VGPNKCRCFPGYT----GKTCSQDVNECGM 100
R + +C E CE G C K EC +G C C PGY G+ C D NEC
Sbjct: 2239 REDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCV-DENECQT 2297
Query: 101 KPRPCQH-RCVNTHGSYKCFCLSGHMLMPDAT-CVNSRT--CAMINCQYSCEDTEE---- 152
KP C++ RC+NT GSY C C G P+ C+++R C Q C+
Sbjct: 2298 KPGICENGRCLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNP 2357
Query: 153 --------------GPQC-LCPSSGL----RLAPNGRDCL----DIDECASGKVICPYNR 189
GP C +CP G +L P+GR + DIDEC +C N
Sbjct: 2358 VTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCR-NG 2416
Query: 190 RCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC-------------TMDSHTCS----- 231
CVN GSY+C C G+ I+G C+D+NEC T S+ CS
Sbjct: 2417 ECVNDRGSYHCICKTGYTPD-ITGT-SCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGY 2474
Query: 232 -------------------HHAN--CFNTQGSFKCKCKQGYKGNGLRC 258
H+ C NT G F CKC G+ + C
Sbjct: 2475 ILQEDGRSCKDLDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSC 2522
Score = 88.2 bits (217), Expect = 2e-17
Identities = 56/163 (34%), Positives = 81/163 (49%), Gaps = 10/163 (6%)
Query: 105 CQH-RCVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYS-CEDTEEGPQCLCPSSG 162
CQ+ RC+ T GS +C C G L C++ C C C + + C C +G
Sbjct: 460 CQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGECINNQGSYTCQC-RAG 518
Query: 163 LRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINE 222
+ +C DIDEC IC N RC+NT GS++C C+ GF + G+ +C D++E
Sbjct: 519 YQSTLTRTECRDIDECLQNGRICN-NGRCINTDGSFHCVCNAGFHVTR-DGK-NCEDMDE 575
Query: 223 CTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAIPE 263
C++ + C N GSFKC CK G++ +G C I E
Sbjct: 576 CSI--RNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINE 616
Score = 87.0 bits (214), Expect = 4e-17
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 45/212 (21%)
Query: 62 EATCEPGC-KFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
+ CE GC G CV PN+C C G+TG C +D + + CF
Sbjct: 147 QPVCESGCLNGGRCVAPNRCACTYGFTGPQCERD------------------YRTGPCFT 188
Query: 121 LSGHML----MPDATCVNSRTCAMINCQYS--CEDTEEGPQCLCPSS----GLRLAPNGR 170
+ + + + C + CA + + CE +CP+ PN R
Sbjct: 189 VISNQMCQGQLSGIVCTKTLCCATVGRAWGHPCE--------MCPAQPHPCRRGFIPNIR 240
Query: 171 D--CLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSH 228
C D+DEC + +C C+NT GS+ CKC G +L +S + C DI+EC+
Sbjct: 241 TGACQDVDECQAIPGLC-QGGNCINTVGSFECKCPAGHKLNEVSQK--CEDIDECSTIPG 297
Query: 229 TCSHHANCFNTQGSFKCKCKQGY--KGNGLRC 258
C C NT S+ CKC G+ +G RC
Sbjct: 298 IC-EGGECTNTVSSYFCKCPPGFYTSPDGTRC 328
Score = 85.9 bits (211), Expect = 9e-17
Identities = 74/243 (30%), Positives = 102/243 (41%), Gaps = 57/243 (23%)
Query: 69 CKFGEC---VGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFC 120
C+ G+C VG +C+C GY G+TC D+NEC ++PR C C N GSY+C C
Sbjct: 1942 CRNGQCINTVGSFQCQCNEGYEVAPDGRTCV-DINECLLEPRKCAPGTCQNLDGSYRCIC 2000
Query: 121 LSGHMLMPDAT-----CVNS-RTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLD 174
G+ L + CV CA+ +C +TE +CLCP G L+ +GR C D
Sbjct: 2001 PPGYSLQNEKCEDIDECVEEPEICAL----GTCSNTEGSFKCLCPE-GFSLSSSGRRCQD 2055
Query: 175 ID------ECASGKVICPYNRRCVNTFGSYYCKCHIGFE--------------------L 208
+ + GK P +R C C + E
Sbjct: 2056 LRMSYCYAKFEGGKCSSPKSRN----HSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2111
Query: 209 QYISGRY-----DCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPE 263
Y SG +D++EC + C H C NT GS++C+C GY G C E
Sbjct: 2112 PYGSGIIVGPDDSAVDMDECK-EPDVCKH-GQCINTDGSYRCECPFGYILAGNECVDTDE 2169
Query: 264 NSV 266
SV
Sbjct: 2170 CSV 2172
Score = 78.2 bits (191), Expect = 2e-14
Identities = 69/243 (28%), Positives = 92/243 (37%), Gaps = 58/243 (23%)
Query: 46 KLACC-YGWRRNSKGVCEATCEPGC-KFGECVGPNKCRCFPG-----YTGKTCSQDVNEC 98
K+ CC Y R CE P +F G + PG YTG D++EC
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQR----PGFVIDIYTGLPV--DIDEC 1770
Query: 99 GMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMINCQYSCEDTEEGPQCL 157
P C++ C+N GS++C C G N +
Sbjct: 1771 REIPGVCENGVCINMVGSFRCECPVGFFY-------NDKLLV------------------ 1805
Query: 158 CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDC 217
C DIDEC +G V C N C+NT GSY C C G+ + C
Sbjct: 1806 --------------CEDIDECQNGPV-CQRNAECINTAGSYRCDCKPGYRF---TSTGQC 1847
Query: 218 IDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTIK 277
D NEC + CSH C +T GSF C C G+K N + + N + GT +
Sbjct: 1848 NDRNECQEIPNICSH-GQCIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCR 1906
Query: 278 DRI 280
+ I
Sbjct: 1907 NTI 1909
Score = 77.8 bits (190), Expect = 2e-14
Identities = 89/349 (25%), Positives = 122/349 (34%), Gaps = 126/349 (36%)
Query: 19 GFGNAASARHHGLLASARQPGVCHYGT--------KLACCYGWRRNSKG-VC-----EAT 64
GF A+ R+ + PG+C G + C G G VC +T
Sbjct: 601 GFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRST 660
Query: 65 CEPGCKFGECVGP-------NKCRCF----------------------------PGYTGK 89
C G K G+C+ P ++C C PG T
Sbjct: 661 CYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMT-- 718
Query: 90 TCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDAT---CVNSRTCAM--INC 143
+ D+NEC + P C + C N G+YKC C SG+ + D+T CV+ C + + C
Sbjct: 719 SAGSDINECALDPDICPNGICENLRGTYKCICNSGYEV--DSTGKNCVDINECVLNSLLC 776
Query: 144 QYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKC 202
C +T C CP G P+ + C DIDEC S I N C N+ GS+ C+C
Sbjct: 777 DNGQCRNTPGSFVCTCPK-GFIYKPDLKTCEDIDECESSPCI---NGVCKNSPGSFICEC 832
Query: 203 HIGFELQ-----------------YISGRYDCIDINECTMDSHTCS-------------- 231
L I GR + I+IN T+ S CS
Sbjct: 833 SSESTLDPTKTICIETIKGTCWQTVIDGRCE-ININGATLKSQCCSSLGAAWGSPCTLCQ 891
Query: 232 ------------------------------HHANCFNTQGSFKCKCKQG 250
+ C NT+GSFKC+C G
Sbjct: 892 VDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSG 940
Score = 77.8 bits (190), Expect = 2e-14
Identities = 78/261 (29%), Positives = 105/261 (40%), Gaps = 61/261 (23%)
Query: 44 GTKLACCYGWRRNSKG-VCEATCEPG----CKFGEC---VGPNKCRCFPGY----TGKTC 91
G + C G+ ++ G CE E C FG C G +C C GY +G C
Sbjct: 1426 GYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNC 1485
Query: 92 SQDVNECGMKPRPC-QHRCVNTHGSYKCFCLSGHMLMPDAT-CVNSRT------------ 137
+ DVNEC + P C CVNT GSY C C L P CV++R+
Sbjct: 1486 T-DVNEC-LDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGD 1543
Query: 138 -------------------CAMINCQYS--CE-----DTEEGPQCLCPSS-GLRLAPNGR 170
C + + CE +T E + LCP G R P
Sbjct: 1544 NGDTACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEY-KILCPGGEGFRPNPITV 1602
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
DIDEC +C +C+NTFGS+ C+C G+ L C D+NEC ++
Sbjct: 1603 ILEDIDECQELPGLCQ-GGKCINTFGSFQCRCPTGYYLN--EDTRVCDDVNEC--ETPGI 1657
Query: 231 SHHANCFNTQGSFKCKCKQGY 251
C+NT G++ C C Y
Sbjct: 1658 CGPGTCYNTVGNYTCICPPDY 1678
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/70 (35%), Positives = 33/70 (47%), Gaps = 3/70 (4%)
Query: 68 GCKFGECVGPNKCRCFPGYTGKTCS---QDVNECGMKPRPCQHRCVNTHGSYKCFCLSGH 124
G +G KC C G+ + S QD+NECG PC + C NT G Y C C G+
Sbjct: 2619 GASCHNTLGSYKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGY 2678
Query: 125 MLMPDATCVN 134
+ CV+
Sbjct: 2679 FRIGQGHCVS 2688
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/113 (32%), Positives = 45/113 (39%), Gaps = 10/113 (8%)
Query: 61 CEAT--CEPGCKFGECVGPNKCRCFPGYTGK---TCSQDVNECGMKPRPCQHRCVNTHGS 115
CE C+ GC+ +G +C C GY D NEC C NT GS
Sbjct: 2571 CEGNHRCQHGCQ--NIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGS 2628
Query: 116 YKCFCLSGHMLMP-DATCVNSRTC--AMINCQYSCEDTEEGPQCLCPSSGLRL 165
YKC C +G C + C A C Y C +TE G C CP R+
Sbjct: 2629 YKCMCPAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYFRI 2681
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 134 bits (337), Expect = 2e-31
Identities = 80/203 (39%), Positives = 107/203 (52%), Gaps = 17/203 (8%)
Query: 60 VCEATCEPG-CKFGECV---GPNKCRCFPGYTGKTCSQDVNECGMKPRPC-QHRCVNTHG 114
V E T PG C G C G +C C G+ G C +DV+EC +P PC RC NT G
Sbjct: 605 VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 664
Query: 115 SYKCFCLSGHMLM-PDATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGR 170
S+ C C +G P A C + CA C Y CE+TE QC+CP G + G
Sbjct: 665 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGS 723
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCK-CHIGFELQYISGRYDCIDINECTMDSHT 229
+C D+DEC + + CP + CVN+ GS+ C+ C G L R C D++EC+ +
Sbjct: 724 ECEDVDECEN-HLACP-GQECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPP 777
Query: 230 CSHHANCFNTQGSFKCKCKQGYK 252
C H +C NT+GSF+C C GY+
Sbjct: 778 CGPHGHCTNTEGSFRCSCAPGYR 800
Score = 107 bits (266), Expect = 4e-23
Identities = 88/271 (32%), Positives = 128/271 (47%), Gaps = 38/271 (14%)
Query: 38 PGVC---HYGTKLACCYGWRRNSKGV-CEATCE-----PGCKFGECV---GPNKCRCFPG 85
PG C G AC G+R + +G C E P C G C G +C C PG
Sbjct: 491 PGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPG 550
Query: 86 Y-TGKTCSQ--DVNECGMKPRPCQ-HRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCAM 140
+ G ++ DV+EC P PC RC NT GS+ C C +G+ P A+C + C
Sbjct: 551 FRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ 610
Query: 141 ---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL-DIDECASGKVICPYNRRCVNTFG 196
+ + +C++ +C+CP+ G R G C D+DECA C R C NT G
Sbjct: 611 SPGLCGRGACKNLPGSFRCVCPA-GFR----GSACEEDVDECAQEPPPCGPGR-CDNTAG 664
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN-- 254
S++C C GF + C D++EC C++ C NT+GSF+C C G++ N
Sbjct: 665 SFHCACPAGFRSRGPGA--PCQDVDECARSPPPCTY-GRCENTEGSFQCVCPMGFQPNTA 721
Query: 255 GLRCSAIP--ENSV----KEVLRAPGTIKDR 279
G C + EN + +E + +PG+ + R
Sbjct: 722 GSECEDVDECENHLACPGQECVNSPGSFQCR 752
Score = 102 bits (254), Expect = 9e-22
Identities = 86/265 (32%), Positives = 115/265 (43%), Gaps = 50/265 (18%)
Query: 41 CHYGTKLACCYGWRRNSKGVCEATCEPGCK-----------------------FGECV-- 75
C G +G N++G +C PG + GEC+
Sbjct: 771 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNT 830
Query: 76 -GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD- 129
G C C PGY G +C DV+EC + C NT GS++C C GH PD
Sbjct: 831 DGSFACTCAPGYRPGPRGASCL-DVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDL 889
Query: 130 ATCVNSRTC-----AMINCQYSCEDTEEGPQCLCPSS-GLRLAPNGRDCLDIDECAS-GK 182
A+C++ C A+ Q CE++ +C+ G P G C D+DEC G
Sbjct: 890 ASCLDVDECRERGPALCGSQ-RCENSPGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGP 947
Query: 183 VICPYNRRCVNTFGSYYCK--CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
IC +RC NT GSY C C G++ G C D++EC S C HA C N
Sbjct: 948 EICGA-QRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHAVCQNLP 1002
Query: 241 GSFKCKCKQGYKG--NGLRCSAIPE 263
GSF+C C QGY+G +G C + E
Sbjct: 1003 GSFQCLCDQGYEGARDGRHCVDVNE 1027
Score = 86.7 bits (213), Expect = 5e-17
Identities = 71/219 (32%), Positives = 98/219 (44%), Gaps = 25/219 (11%)
Query: 49 CCYGWRRNSKG-----VCEATCEPGCKFGECV---GPNKCRCFPGYTGK---TCSQDVNE 97
C G+R +G V E + E C+ G C G +C C PG+ DV+E
Sbjct: 838 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 897
Query: 98 CGMK-PRPC-QHRCVNTHGSYKCF--CLSGHMLMPDATCVNSRTCAMINCQYS----CED 149
C + P C RC N+ GSY+C C G+ P+ TC + C + CE+
Sbjct: 898 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 957
Query: 150 TEEGPQCL-CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
T +C G + P G C D+DEC + + C + C N GS+ C C G+E
Sbjct: 958 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEG 1015
Query: 209 QYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
GR+ C+D+NEC C A C N +GSF C C
Sbjct: 1016 AR-DGRH-CVDVNECETLQGVCGA-ALCENVEGSFLCVC 1051
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
+C +D C +G RCV + C+C G+ L R C+DINEC ++
Sbjct: 1469 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMT--RMACVDINECD-EAEAA 1517
Query: 231 SH---HANCFNTQGSFKCKCKQGY 251
S +A C NT GSF+C C+ G+
Sbjct: 1518 SPLCVNARCLNTDGSFRCICRPGF 1541
Score = 49.3 bits (116), Expect = 9e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCH--- 203
C +T G C C S+G +C+D DECA + C RCVNT GSY+C C
Sbjct: 1203 CVNTAPGYSCYC-SNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHCTCEPPL 1260
Query: 204 --IGFELQYISGRYDCIDIN--ECTMD---SHTCSHHANCFNTQGSF-KCKCKQGYKGNG 255
G + + +S +D N C + CSH + Q ++ +C C G + G
Sbjct: 1261 VLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR--LDRQATYTECCCLYG-EAWG 1317
Query: 256 LRCSAIP 262
+ C+ P
Sbjct: 1318 MDCALCP 1324
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 68 GCKFGECVGPNK---CRCFPGY----TGKTCSQDVNEC----GMKPRPCQHRCVNTHGSY 116
GC G CV + CRCF GY T C D+NEC P RC+NT GS+
Sbjct: 1475 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVNARCLNTDGSF 1533
Query: 117 KCFCLSG 123
+C C G
Sbjct: 1534 RCICRPG 1540
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/144 (28%), Positives = 57/144 (39%), Gaps = 20/144 (13%)
Query: 49 CCYGWRRNSKGVCEATCEPGCKFGECVGPNKCR-----------CFPGYT---GKTCSQD 94
C G+ +G C+ E E G +C C PGY G C QD
Sbjct: 924 CDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGC-QD 982
Query: 95 VNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMIN--CQYS-CED 149
V+EC + H C N GS++C C G+ D CV+ C + C + CE+
Sbjct: 983 VDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1042
Query: 150 TEEGPQCLCPSSGLRLAPNGRDCL 173
E C+CP+S P C+
Sbjct: 1043 VEGSFLCVCPNSPEEFDPMTGRCV 1066
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/62 (40%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICP--YNRRCVNTFGSYYCKCHI 204
C EG C C G RL C+DI+EC + P N RC+NT GS+ C C
Sbjct: 1481 CVRVPEGFTCRC-FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1539
Query: 205 GF 206
GF
Sbjct: 1540 GF 1541
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 7/81 (8%)
Query: 138 CAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGS 197
C + + + + P CP+ R+ NG C D+DECA+G C + C NT G
Sbjct: 257 CQLCSERLGNSERVSAPDGPCPTGFERV--NG-SCEDVDECATGGR-CQHGE-CANTRGG 311
Query: 198 YYCKCHIGFELQYISGRYDCI 218
Y C C GF L S R CI
Sbjct: 312 YTCVCPDGFLLD--SSRSSCI 330
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 6/67 (8%)
Query: 202 CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAI 261
C GFE ++G C D++EC H C NT+G + C C G+ + R S I
Sbjct: 277 CPTGFER--VNG--SCEDVDECATGGRC--QHGECANTRGGYTCVCPDGFLLDSSRSSCI 330
Query: 262 PENSVKE 268
++ + E
Sbjct: 331 SQHVISE 337
Score = 39.3 bits (90), Expect = 0.010
Identities = 33/114 (28%), Positives = 45/114 (39%), Gaps = 9/114 (7%)
Query: 16 VAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG--WRRNSKGVCEATCEPGCKFGE 73
V G+G+ + +A +C +G G R C+ + CK G
Sbjct: 1143 VGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV 1202
Query: 74 CVGPN---KCRCFPGY---TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFC 120
CV C C GY T + D +EC + C+ RCVNT GSY C C
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTC 1256
Score = 38.1 bits (87), Expect = 0.021
Identities = 37/116 (31%), Positives = 46/116 (39%), Gaps = 15/116 (12%)
Query: 17 AGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG----WRRNSKGVCEATCEPGCKFG 72
A GFG G AS PG+ T+ CC G W + +C +
Sbjct: 216 ASGFGYCFRELRGGECASPL-PGL---RTQEVCCRGAGLAWGVHDCQLCSERLGNSERVS 271
Query: 73 ECVGPNKCRCFPGYTGKTCS-QDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML 126
GP C G+ S +DV+EC R CQH C NT G Y C C G +L
Sbjct: 272 APDGP----CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLL 322
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 5/43 (11%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKP 102
+C C G G CV P++C C P + GK C ++ G +P
Sbjct: 85 LCPLICHNG---GVCVKPDRCLCPPDFAGKFC--QLHSSGARP 122
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 134 bits (337), Expect = 2e-31
Identities = 80/203 (39%), Positives = 107/203 (52%), Gaps = 17/203 (8%)
Query: 60 VCEATCEPG-CKFGECV---GPNKCRCFPGYTGKTCSQDVNECGMKPRPC-QHRCVNTHG 114
V E T PG C G C G +C C G+ G C +DV+EC +P PC RC NT G
Sbjct: 635 VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 694
Query: 115 SYKCFCLSGHMLM-PDATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGR 170
S+ C C +G P A C + CA C Y CE+TE QC+CP G + G
Sbjct: 695 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGS 753
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCK-CHIGFELQYISGRYDCIDINECTMDSHT 229
+C D+DEC + + CP + CVN+ GS+ C+ C G L R C D++EC+ +
Sbjct: 754 ECEDVDECEN-HLACP-GQECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPP 807
Query: 230 CSHHANCFNTQGSFKCKCKQGYK 252
C H +C NT+GSF+C C GY+
Sbjct: 808 CGPHGHCTNTEGSFRCSCAPGYR 830
Score = 107 bits (266), Expect = 4e-23
Identities = 88/271 (32%), Positives = 128/271 (47%), Gaps = 38/271 (14%)
Query: 38 PGVC---HYGTKLACCYGWRRNSKGV-CEATCE-----PGCKFGECV---GPNKCRCFPG 85
PG C G AC G+R + +G C E P C G C G +C C PG
Sbjct: 521 PGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPG 580
Query: 86 Y-TGKTCSQ--DVNECGMKPRPCQ-HRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCAM 140
+ G ++ DV+EC P PC RC NT GS+ C C +G+ P A+C + C
Sbjct: 581 FRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ 640
Query: 141 ---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL-DIDECASGKVICPYNRRCVNTFG 196
+ + +C++ +C+CP+ G R G C D+DECA C R C NT G
Sbjct: 641 SPGLCGRGACKNLPGSFRCVCPA-GFR----GSACEEDVDECAQEPPPCGPGR-CDNTAG 694
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN-- 254
S++C C GF + C D++EC C++ C NT+GSF+C C G++ N
Sbjct: 695 SFHCACPAGFRSRGPGA--PCQDVDECARSPPPCTY-GRCENTEGSFQCVCPMGFQPNTA 751
Query: 255 GLRCSAIP--ENSV----KEVLRAPGTIKDR 279
G C + EN + +E + +PG+ + R
Sbjct: 752 GSECEDVDECENHLACPGQECVNSPGSFQCR 782
Score = 102 bits (254), Expect = 9e-22
Identities = 86/265 (32%), Positives = 115/265 (43%), Gaps = 50/265 (18%)
Query: 41 CHYGTKLACCYGWRRNSKGVCEATCEPGCK-----------------------FGECV-- 75
C G +G N++G +C PG + GEC+
Sbjct: 801 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNT 860
Query: 76 -GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD- 129
G C C PGY G +C DV+EC + C NT GS++C C GH PD
Sbjct: 861 DGSFACTCAPGYRPGPRGASCL-DVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDL 919
Query: 130 ATCVNSRTC-----AMINCQYSCEDTEEGPQCLCPSS-GLRLAPNGRDCLDIDECAS-GK 182
A+C++ C A+ Q CE++ +C+ G P G C D+DEC G
Sbjct: 920 ASCLDVDECRERGPALCGSQ-RCENSPGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGP 977
Query: 183 VICPYNRRCVNTFGSYYCK--CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
IC +RC NT GSY C C G++ G C D++EC S C HA C N
Sbjct: 978 EICGA-QRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHAVCQNLP 1032
Query: 241 GSFKCKCKQGYKG--NGLRCSAIPE 263
GSF+C C QGY+G +G C + E
Sbjct: 1033 GSFQCLCDQGYEGARDGRHCVDVNE 1057
Score = 86.7 bits (213), Expect = 5e-17
Identities = 71/219 (32%), Positives = 98/219 (44%), Gaps = 25/219 (11%)
Query: 49 CCYGWRRNSKG-----VCEATCEPGCKFGECV---GPNKCRCFPGYTGK---TCSQDVNE 97
C G+R +G V E + E C+ G C G +C C PG+ DV+E
Sbjct: 868 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 927
Query: 98 CGMK-PRPC-QHRCVNTHGSYKCF--CLSGHMLMPDATCVNSRTCAMINCQYS----CED 149
C + P C RC N+ GSY+C C G+ P+ TC + C + CE+
Sbjct: 928 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 987
Query: 150 TEEGPQCL-CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
T +C G + P G C D+DEC + + C + C N GS+ C C G+E
Sbjct: 988 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEG 1045
Query: 209 QYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
GR+ C+D+NEC C A C N +GSF C C
Sbjct: 1046 AR-DGRH-CVDVNECETLQGVCGA-ALCENVEGSFLCVC 1081
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
+C +D C +G RCV + C+C G+ L R C+DINEC ++
Sbjct: 1499 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMT--RMACVDINECD-EAEAA 1547
Query: 231 SH---HANCFNTQGSFKCKCKQGY 251
S +A C NT GSF+C C+ G+
Sbjct: 1548 SPLCVNARCLNTDGSFRCICRPGF 1571
Score = 49.3 bits (116), Expect = 9e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCH--- 203
C +T G C C S+G +C+D DECA + C RCVNT GSY+C C
Sbjct: 1233 CVNTAPGYSCYC-SNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHCTCEPPL 1290
Query: 204 --IGFELQYISGRYDCIDIN--ECTMD---SHTCSHHANCFNTQGSF-KCKCKQGYKGNG 255
G + + +S +D N C + CSH + Q ++ +C C G + G
Sbjct: 1291 VLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR--LDRQATYTECCCLYG-EAWG 1347
Query: 256 LRCSAIP 262
+ C+ P
Sbjct: 1348 MDCALCP 1354
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 68 GCKFGECVGPNK---CRCFPGY----TGKTCSQDVNEC----GMKPRPCQHRCVNTHGSY 116
GC G CV + CRCF GY T C D+NEC P RC+NT GS+
Sbjct: 1505 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVNARCLNTDGSF 1563
Query: 117 KCFCLSG 123
+C C G
Sbjct: 1564 RCICRPG 1570
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/144 (28%), Positives = 57/144 (39%), Gaps = 20/144 (13%)
Query: 49 CCYGWRRNSKGVCEATCEPGCKFGECVGPNKCR-----------CFPGYT---GKTCSQD 94
C G+ +G C+ E E G +C C PGY G C QD
Sbjct: 954 CDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGC-QD 1012
Query: 95 VNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMIN--CQYS-CED 149
V+EC + H C N GS++C C G+ D CV+ C + C + CE+
Sbjct: 1013 VDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1072
Query: 150 TEEGPQCLCPSSGLRLAPNGRDCL 173
E C+CP+S P C+
Sbjct: 1073 VEGSFLCVCPNSPEEFDPMTGRCV 1096
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/62 (40%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICP--YNRRCVNTFGSYYCKCHI 204
C EG C C G RL C+DI+EC + P N RC+NT GS+ C C
Sbjct: 1511 CVRVPEGFTCRC-FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1569
Query: 205 GF 206
GF
Sbjct: 1570 GF 1571
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 7/81 (8%)
Query: 138 CAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGS 197
C + + + + P CP+ R+ NG C D+DECA+G C + C NT G
Sbjct: 287 CQLCSERLGNSERVSAPDGPCPTGFERV--NG-SCEDVDECATGGR-CQHGE-CANTRGG 341
Query: 198 YYCKCHIGFELQYISGRYDCI 218
Y C C GF L S R CI
Sbjct: 342 YTCVCPDGFLLD--SSRSSCI 360
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 6/67 (8%)
Query: 202 CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAI 261
C GFE ++G C D++EC H C NT+G + C C G+ + R S I
Sbjct: 307 CPTGFER--VNG--SCEDVDECATGGRC--QHGECANTRGGYTCVCPDGFLLDSSRSSCI 360
Query: 262 PENSVKE 268
++ + E
Sbjct: 361 SQHVISE 367
Score = 39.3 bits (90), Expect = 0.010
Identities = 33/114 (28%), Positives = 45/114 (39%), Gaps = 9/114 (7%)
Query: 16 VAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG--WRRNSKGVCEATCEPGCKFGE 73
V G+G+ + +A +C +G G R C+ + CK G
Sbjct: 1173 VGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV 1232
Query: 74 CVGPN---KCRCFPGY---TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFC 120
CV C C GY T + D +EC + C+ RCVNT GSY C C
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTC 1286
Score = 38.1 bits (87), Expect = 0.021
Identities = 37/116 (31%), Positives = 46/116 (39%), Gaps = 15/116 (12%)
Query: 17 AGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG----WRRNSKGVCEATCEPGCKFG 72
A GFG G AS PG+ T+ CC G W + +C +
Sbjct: 246 ASGFGYCFRELRGGECASPL-PGL---RTQEVCCRGAGLAWGVHDCQLCSERLGNSERVS 301
Query: 73 ECVGPNKCRCFPGYTGKTCS-QDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML 126
GP C G+ S +DV+EC R CQH C NT G Y C C G +L
Sbjct: 302 APDGP----CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLL 352
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 5/43 (11%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKP 102
+C C G G CV P++C C P + GK C ++ G +P
Sbjct: 115 LCPLICHNG---GVCVKPDRCLCPPDFAGKFC--QLHSSGARP 152
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 134 bits (337), Expect = 2e-31
Identities = 80/203 (39%), Positives = 107/203 (52%), Gaps = 17/203 (8%)
Query: 60 VCEATCEPG-CKFGECV---GPNKCRCFPGYTGKTCSQDVNECGMKPRPC-QHRCVNTHG 114
V E T PG C G C G +C C G+ G C +DV+EC +P PC RC NT G
Sbjct: 672 VDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAG 731
Query: 115 SYKCFCLSGHMLM-PDATCVNSRTCAMIN--CQYS-CEDTEEGPQCLCPSSGLRLAPNGR 170
S+ C C +G P A C + CA C Y CE+TE QC+CP G + G
Sbjct: 732 SFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPM-GFQPNTAGS 790
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCK-CHIGFELQYISGRYDCIDINECTMDSHT 229
+C D+DEC + + CP + CVN+ GS+ C+ C G L R C D++EC+ +
Sbjct: 791 ECEDVDECEN-HLACP-GQECVNSPGSFQCRTCPSGHHLH----RGRCTDVDECSSGAPP 844
Query: 230 CSHHANCFNTQGSFKCKCKQGYK 252
C H +C NT+GSF+C C GY+
Sbjct: 845 CGPHGHCTNTEGSFRCSCAPGYR 867
Score = 107 bits (266), Expect = 4e-23
Identities = 88/271 (32%), Positives = 128/271 (47%), Gaps = 38/271 (14%)
Query: 38 PGVC---HYGTKLACCYGWRRNSKGV-CEATCE-----PGCKFGECV---GPNKCRCFPG 85
PG C G AC G+R + +G C E P C G C G +C C PG
Sbjct: 558 PGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPG 617
Query: 86 Y-TGKTCSQ--DVNECGMKPRPCQ-HRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCAM 140
+ G ++ DV+EC P PC RC NT GS+ C C +G+ P A+C + C
Sbjct: 618 FRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQ 677
Query: 141 ---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL-DIDECASGKVICPYNRRCVNTFG 196
+ + +C++ +C+CP+ G R G C D+DECA C R C NT G
Sbjct: 678 SPGLCGRGACKNLPGSFRCVCPA-GFR----GSACEEDVDECAQEPPPCGPGR-CDNTAG 731
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN-- 254
S++C C GF + C D++EC C++ C NT+GSF+C C G++ N
Sbjct: 732 SFHCACPAGFRSRGPGA--PCQDVDECARSPPPCTY-GRCENTEGSFQCVCPMGFQPNTA 788
Query: 255 GLRCSAIP--ENSV----KEVLRAPGTIKDR 279
G C + EN + +E + +PG+ + R
Sbjct: 789 GSECEDVDECENHLACPGQECVNSPGSFQCR 819
Score = 102 bits (254), Expect = 9e-22
Identities = 86/265 (32%), Positives = 115/265 (43%), Gaps = 50/265 (18%)
Query: 41 CHYGTKLACCYGWRRNSKGVCEATCEPGCK-----------------------FGECV-- 75
C G +G N++G +C PG + GEC+
Sbjct: 838 CSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCFPHGECLNT 897
Query: 76 -GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD- 129
G C C PGY G +C DV+EC + C NT GS++C C GH PD
Sbjct: 898 DGSFACTCAPGYRPGPRGASCL-DVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDL 956
Query: 130 ATCVNSRTC-----AMINCQYSCEDTEEGPQCLCPSS-GLRLAPNGRDCLDIDECAS-GK 182
A+C++ C A+ Q CE++ +C+ G P G C D+DEC G
Sbjct: 957 ASCLDVDECRERGPALCGSQ-RCENSPGSYRCVRDCDPGYHAGPEGT-CDDVDECQEYGP 1014
Query: 183 VICPYNRRCVNTFGSYYCK--CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
IC +RC NT GSY C C G++ G C D++EC S C HA C N
Sbjct: 1015 EICGA-QRCENTPGSYRCTPACDPGYQPTPGGG---CQDVDECRNRSF-CGAHAVCQNLP 1069
Query: 241 GSFKCKCKQGYKG--NGLRCSAIPE 263
GSF+C C QGY+G +G C + E
Sbjct: 1070 GSFQCLCDQGYEGARDGRHCVDVNE 1094
Score = 86.7 bits (213), Expect = 5e-17
Identities = 71/219 (32%), Positives = 98/219 (44%), Gaps = 25/219 (11%)
Query: 49 CCYGWRRNSKG-----VCEATCEPGCKFGECV---GPNKCRCFPGYTGK---TCSQDVNE 97
C G+R +G V E + E C+ G C G +C C PG+ DV+E
Sbjct: 905 CAPGYRPGPRGASCLDVDECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDE 964
Query: 98 CGMK-PRPC-QHRCVNTHGSYKCF--CLSGHMLMPDATCVNSRTCAMINCQYS----CED 149
C + P C RC N+ GSY+C C G+ P+ TC + C + CE+
Sbjct: 965 CRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQRCEN 1024
Query: 150 TEEGPQCL-CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
T +C G + P G C D+DEC + + C + C N GS+ C C G+E
Sbjct: 1025 TPGSYRCTPACDPGYQPTPGG-GCQDVDECRN-RSFCGAHAVCQNLPGSFQCLCDQGYEG 1082
Query: 209 QYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
GR+ C+D+NEC C A C N +GSF C C
Sbjct: 1083 AR-DGRH-CVDVNECETLQGVCGA-ALCENVEGSFLCVC 1118
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
+C +D C +G RCV + C+C G+ L R C+DINEC ++
Sbjct: 1536 ECGILDGCTNG--------RCVRVPEGFTCRCFDGYRLDMT--RMACVDINECD-EAEAA 1584
Query: 231 SH---HANCFNTQGSFKCKCKQGY 251
S +A C NT GSF+C C+ G+
Sbjct: 1585 SPLCVNARCLNTDGSFRCICRPGF 1608
Score = 49.3 bits (116), Expect = 9e-06
Identities = 39/127 (30%), Positives = 57/127 (44%), Gaps = 16/127 (12%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCH--- 203
C +T G C C S+G +C+D DECA + C RCVNT GSY+C C
Sbjct: 1270 CVNTAPGYSCYC-SNGYYYHTQRLECIDNDECADEEPACE-GGRCVNTVGSYHCTCEPPL 1327
Query: 204 --IGFELQYISGRYDCIDIN--ECTMD---SHTCSHHANCFNTQGSF-KCKCKQGYKGNG 255
G + + +S +D N C + CSH + Q ++ +C C G + G
Sbjct: 1328 VLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVCSHPR--LDRQATYTECCCLYG-EAWG 1384
Query: 256 LRCSAIP 262
+ C+ P
Sbjct: 1385 MDCALCP 1391
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/67 (40%), Positives = 32/67 (47%), Gaps = 12/67 (17%)
Query: 68 GCKFGECVGPNK---CRCFPGY----TGKTCSQDVNEC----GMKPRPCQHRCVNTHGSY 116
GC G CV + CRCF GY T C D+NEC P RC+NT GS+
Sbjct: 1542 GCTNGRCVRVPEGFTCRCFDGYRLDMTRMACV-DINECDEAEAASPLCVNARCLNTDGSF 1600
Query: 117 KCFCLSG 123
+C C G
Sbjct: 1601 RCICRPG 1607
Score = 45.4 bits (106), Expect = 1e-04
Identities = 41/144 (28%), Positives = 57/144 (39%), Gaps = 20/144 (13%)
Query: 49 CCYGWRRNSKGVCEATCEPGCKFGECVGPNKCR-----------CFPGYT---GKTCSQD 94
C G+ +G C+ E E G +C C PGY G C QD
Sbjct: 991 CDPGYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGC-QD 1049
Query: 95 VNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMIN--CQYS-CED 149
V+EC + H C N GS++C C G+ D CV+ C + C + CE+
Sbjct: 1050 VDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQGVCGAALCEN 1109
Query: 150 TEEGPQCLCPSSGLRLAPNGRDCL 173
E C+CP+S P C+
Sbjct: 1110 VEGSFLCVCPNSPEEFDPMTGRCV 1133
Score = 45.1 bits (105), Expect = 2e-04
Identities = 25/62 (40%), Positives = 30/62 (48%), Gaps = 3/62 (4%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICP--YNRRCVNTFGSYYCKCHI 204
C EG C C G RL C+DI+EC + P N RC+NT GS+ C C
Sbjct: 1548 CVRVPEGFTCRC-FDGYRLDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCICRP 1606
Query: 205 GF 206
GF
Sbjct: 1607 GF 1608
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 7/81 (8%)
Query: 138 CAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGS 197
C + + + + P CP+ R+ NG C D+DECA+G C + C NT G
Sbjct: 324 CQLCSERLGNSERVSAPDGPCPTGFERV--NG-SCEDVDECATGGR-CQHGE-CANTRGG 378
Query: 198 YYCKCHIGFELQYISGRYDCI 218
Y C C GF L S R CI
Sbjct: 379 YTCVCPDGFLLD--SSRSSCI 397
Score = 39.7 bits (91), Expect = 0.007
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 6/67 (8%)
Query: 202 CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAI 261
C GFE ++G C D++EC H C NT+G + C C G+ + R S I
Sbjct: 344 CPTGFER--VNG--SCEDVDECATGGRC--QHGECANTRGGYTCVCPDGFLLDSSRSSCI 397
Query: 262 PENSVKE 268
++ + E
Sbjct: 398 SQHVISE 404
Score = 39.3 bits (90), Expect = 0.010
Identities = 33/114 (28%), Positives = 45/114 (39%), Gaps = 9/114 (7%)
Query: 16 VAGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG--WRRNSKGVCEATCEPGCKFGE 73
V G+G+ + +A +C +G G R C+ + CK G
Sbjct: 1210 VGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGV 1269
Query: 74 CVGPN---KCRCFPGY---TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFC 120
CV C C GY T + D +EC + C+ RCVNT GSY C C
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTC 1323
Score = 38.1 bits (87), Expect = 0.021
Identities = 37/116 (31%), Positives = 46/116 (39%), Gaps = 15/116 (12%)
Query: 17 AGGFGNAASARHHGLLASARQPGVCHYGTKLACCYG----WRRNSKGVCEATCEPGCKFG 72
A GFG G AS PG+ T+ CC G W + +C +
Sbjct: 283 ASGFGYCFRELRGGECASPL-PGL---RTQEVCCRGAGLAWGVHDCQLCSERLGNSERVS 338
Query: 73 ECVGPNKCRCFPGYTGKTCS-QDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHML 126
GP C G+ S +DV+EC R CQH C NT G Y C C G +L
Sbjct: 339 APDGP----CPTGFERVNGSCEDVDECATGGR-CQHGECANTRGGYTCVCPDGFLL 389
Score = 32.3 bits (72), Expect = 1.2
Identities = 15/43 (34%), Positives = 22/43 (51%), Gaps = 5/43 (11%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKP 102
+C C G G CV P++C C P + GK C ++ G +P
Sbjct: 152 LCPLICHNG---GVCVKPDRCLCPPDFAGKFC--QLHSSGARP 189
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 131 bits (330), Expect = 1e-30
Identities = 84/225 (37%), Positives = 107/225 (47%), Gaps = 25/225 (11%)
Query: 47 LACCYGWRRNSKG---VCEATCEPG---CKFGECV----GPNKCRCFPGYT----GKTCS 92
L C G+ + G V CE G C G+ G +C C G+ G+ C
Sbjct: 841 LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 900
Query: 93 QDVNECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMINCQYSCEDT 150
DVNEC P R CQH C NT GSY+C C SG +L D C + C C C +
Sbjct: 901 -DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANI 959
Query: 151 EEGPQCLCPSSGLRLAPNGRDCLDIDECASGK-VICPYNRRCVNTFGSYYCKCHIGFELQ 209
QC C G +LA +G C DIDECA G ++C + RC+N GSY C C
Sbjct: 960 YGSYQCYC-RQGYQLAEDGHTCTDIDECAQGAGILCTF--RCLNVPGSYQCACPEQGYTM 1016
Query: 210 YISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGY 251
+GR C D++EC + +H CS C N QGSF+C +C Y
Sbjct: 1017 TANGR-SCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1060
Score = 105 bits (261), Expect = 1e-22
Identities = 61/192 (31%), Positives = 87/192 (45%), Gaps = 33/192 (17%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGS 115
+C+ TCE +G +C C G+ GK C +DVNEC + + C C N +GS
Sbjct: 912 LCQHTCE------NTLGSYRCSCASGFLLAADGKRC-EDVNEC--EAQRCSQECANIYGS 962
Query: 116 YKCFCLSGHMLMPDA-TCVNSRTCAM---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRD 171
Y+C+C G+ L D TC + CA I C + C + QC CP G + NGR
Sbjct: 963 YQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRS 1022
Query: 172 CLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDC----IDINECTMDS 227
C D+DECA G C C N GS+ C R++C + +++ +
Sbjct: 1023 CKDVDECALGTHNCSEAETCHNIQGSFRCL------------RFECPPNYVQVSKTKCER 1070
Query: 228 HTCSHHANCFNT 239
TC C N+
Sbjct: 1071 TTCHDFLECQNS 1082
Score = 104 bits (259), Expect = 2e-22
Identities = 72/219 (32%), Positives = 99/219 (45%), Gaps = 30/219 (13%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQH--RCVNTHGSYKCF----CLSGHMLMPD 129
C CFPGY G +C +D+NEC C CVNT GS+ C+ C G+ L D
Sbjct: 702 CSCFPGYAIMADGVSC-EDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALK-D 759
Query: 130 ATCVNSRTCAM--INCQ--YSCEDTEEGPQCLCPS---SGLRLAPNGRDCLDIDECASGK 182
C + CAM CQ + C++T+ C G P G +C+DI+EC S
Sbjct: 760 GECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLS 818
Query: 183 VICPYNRRCVNTFGSYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCF 237
C C+NT GSY C+ C G+ + C+D+NEC H C C
Sbjct: 819 EPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTK--CVDVNECETGVHRCGEGQVCH 876
Query: 238 NTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTI 276
N GS++C CK G++ + I V E +PG +
Sbjct: 877 NLPGSYRCDCKAGFQRDAFGRGCI---DVNECWASPGRL 912
Score = 99.0 bits (245), Expect = 1e-20
Identities = 75/221 (33%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 64 TCEPGCKFGECVGPNKC----RCFPGYTGKTCSQ--DVNECGMKPRPCQ--HRCVNTHGS 115
TC+PG G C RC G+ D+NEC PC+ C+NT GS
Sbjct: 774 TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGS 833
Query: 116 YKC-----FCLSGHMLMPDAT-CVNSRTC--AMINCQYS--CEDTEEGPQCLCPSSGLRL 165
Y C C G+ D T CV+ C + C C + +C C +G +
Sbjct: 834 YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC-KAGFQR 892
Query: 166 APNGRDCLDIDEC-ASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECT 224
GR C+D++EC AS +C + C NT GSY C C GF L R C D+NEC
Sbjct: 893 DAFGRGCIDVNECWASPGRLCQHT--CENTLGSYRCSCASGFLLAADGKR--CEDVNEC- 947
Query: 225 MDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAIPE 263
++ CS C N GS++C C+QGY+ +G C+ I E
Sbjct: 948 -EAQRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDE 985
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/192 (31%), Positives = 79/192 (41%), Gaps = 37/192 (19%)
Query: 94 DVNECGMKPRP-CQHRCVNTHGSYKCFCLSGHMLMPDA-TC------------------- 132
D +EC + P CQH C+NT GSY C C G L D TC
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 133 ----VNSRTCAMI-----------NCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
V S T + C+ C C C G + +G C DI+E
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSC-FPGYAIMADGVSCEDINE 722
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCF 237
C + C CVNT GS++C + E Y +C D++EC M +HTC C
Sbjct: 723 CVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQ 782
Query: 238 NTQGSFKCKCKQ 249
NT+GSF C+ +Q
Sbjct: 783 NTKGSFYCQARQ 794
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 131 bits (330), Expect = 1e-30
Identities = 84/225 (37%), Positives = 107/225 (47%), Gaps = 25/225 (11%)
Query: 47 LACCYGWRRNSKG---VCEATCEPG---CKFGECV----GPNKCRCFPGYT----GKTCS 92
L C G+ + G V CE G C G+ G +C C G+ G+ C
Sbjct: 888 LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCI 947
Query: 93 QDVNECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMINCQYSCEDT 150
DVNEC P R CQH C NT GSY+C C SG +L D C + C C C +
Sbjct: 948 -DVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCSQECANI 1006
Query: 151 EEGPQCLCPSSGLRLAPNGRDCLDIDECASGK-VICPYNRRCVNTFGSYYCKCHIGFELQ 209
QC C G +LA +G C DIDECA G ++C + RC+N GSY C C
Sbjct: 1007 YGSYQCYC-RQGYQLAEDGHTCTDIDECAQGAGILCTF--RCLNVPGSYQCACPEQGYTM 1063
Query: 210 YISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGY 251
+GR C D++EC + +H CS C N QGSF+C +C Y
Sbjct: 1064 TANGR-SCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPNY 1107
Score = 105 bits (261), Expect = 1e-22
Identities = 61/192 (31%), Positives = 87/192 (45%), Gaps = 33/192 (17%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGS 115
+C+ TCE +G +C C G+ GK C +DVNEC + + C C N +GS
Sbjct: 959 LCQHTCE------NTLGSYRCSCASGFLLAADGKRC-EDVNEC--EAQRCSQECANIYGS 1009
Query: 116 YKCFCLSGHMLMPDA-TCVNSRTCAM---INCQYSCEDTEEGPQCLCPSSGLRLAPNGRD 171
Y+C+C G+ L D TC + CA I C + C + QC CP G + NGR
Sbjct: 1010 YQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRS 1069
Query: 172 CLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDC----IDINECTMDS 227
C D+DECA G C C N GS+ C R++C + +++ +
Sbjct: 1070 CKDVDECALGTHNCSEAETCHNIQGSFRCL------------RFECPPNYVQVSKTKCER 1117
Query: 228 HTCSHHANCFNT 239
TC C N+
Sbjct: 1118 TTCHDFLECQNS 1129
Score = 99.8 bits (247), Expect = 6e-21
Identities = 71/230 (30%), Positives = 91/230 (39%), Gaps = 43/230 (18%)
Query: 94 DVNECGMKPRP-CQHRCVNTHGSYKCFCLSGHMLMPDA-TC------------------- 132
D +EC + P CQH C+NT GSY C C G L D TC
Sbjct: 604 DQDECLLLPGELCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKS 663
Query: 133 ----VNSRTCAMI-----------NCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
V S T + C+ C C C G + +G C D DE
Sbjct: 664 EFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSC-FPGYAIMADGVSCEDQDE 722
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCH--IGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
C G C + CVNT GS+YC H + + ++ C+DINEC D HTCS +
Sbjct: 723 CLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEH 782
Query: 236 CFNTQGSFKC----KCKQGYKGNGLRCSAIPENSVKEVLRAPGTIKDRIK 281
C NT GSF C C+ GY C + E ++ PG + K
Sbjct: 783 CVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTK 832
Score = 99.0 bits (245), Expect = 1e-20
Identities = 75/221 (33%), Positives = 101/221 (45%), Gaps = 30/221 (13%)
Query: 64 TCEPGCKFGECVGPNKC----RCFPGYTGKTCSQ--DVNECGMKPRPCQ--HRCVNTHGS 115
TC+PG G C RC G+ D+NEC PC+ C+NT GS
Sbjct: 821 TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGS 880
Query: 116 YKC-----FCLSGHMLMPDAT-CVNSRTC--AMINCQYS--CEDTEEGPQCLCPSSGLRL 165
Y C C G+ D T CV+ C + C C + +C C +G +
Sbjct: 881 YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC-KAGFQR 939
Query: 166 APNGRDCLDIDEC-ASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECT 224
GR C+D++EC AS +C + C NT GSY C C GF L R C D+NEC
Sbjct: 940 DAFGRGCIDVNECWASPGRLCQHT--CENTLGSYRCSCASGFLLAADGKR--CEDVNEC- 994
Query: 225 MDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAIPE 263
++ CS C N GS++C C+QGY+ +G C+ I E
Sbjct: 995 -EAQRCSQE--CANIYGSYQCYCRQGYQLAEDGHTCTDIDE 1032
Score = 92.4 bits (228), Expect = 9e-19
Identities = 74/265 (27%), Positives = 102/265 (38%), Gaps = 75/265 (28%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQHR--CVNTHGSYKC-----FCLSGHMLMP 128
C CFPGY G +C +D +EC M C R CVNT GS+ C C G++L
Sbjct: 702 CSCFPGYAIMADGVSC-EDQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNA 760
Query: 129 DATCVNSRTCAM-----------------------INCQYS-------CEDTEE------ 152
CV+ C + C+ CED +E
Sbjct: 761 HRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTH 820
Query: 153 --GPQCLCPSS--------------GLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFG 196
P LC ++ G P G +C+DI+EC S C C+NT G
Sbjct: 821 TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEG-NCVDINECTSLSEPCRPGFSCINTVG 879
Query: 197 SYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
SY C+ C G+ + C+D+NEC H C C N GS++C CK G+
Sbjct: 880 SYTCQRNPLICARGYHASDDGTK--CVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGF 937
Query: 252 KGNGLRCSAIPENSVKEVLRAPGTI 276
+ + I V E +PG +
Sbjct: 938 QRDAFGRGCI---DVNECWASPGRL 959
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 129 bits (325), Expect = 5e-30
Identities = 83/210 (39%), Positives = 108/210 (51%), Gaps = 21/210 (10%)
Query: 64 TCEPGCKFGECVGPNKC--RCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYK 117
TC G +G +C RC G+ G +C QD+NEC + PC RC N GS+
Sbjct: 5157 TCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSC-QDINEC-QESSPCHQRCFNAIGSFH 5214
Query: 118 CFCLSGHMLMPDATCVNSRTCAMINCQ--YSCEDTEEGPQC--LCPSSGLRLAPNGRDCL 173
C C G+ L C++ C C+ C++T G +C LCP+ G+ A NG C+
Sbjct: 5215 CGCEPGYQLK-GRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPN-GMTKAENGT-CI 5271
Query: 174 DIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHH 233
DIDEC G C YN+ C NT GSY C C G+ Q + GR C+DINEC C+H
Sbjct: 5272 DIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV-GR-PCMDINECEQVPKPCAHQ 5329
Query: 234 ANCFNTQGSFKCKCKQGYK--GNGLRCSAI 261
C NT GSFKC C G G+G C+ +
Sbjct: 5330 --CSNTPGSFKCICPPGQHLLGDGKSCAGL 5357
Score = 103 bits (258), Expect = 3e-22
Identities = 71/258 (27%), Positives = 107/258 (41%), Gaps = 61/258 (23%)
Query: 76 GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA- 130
G +C G+T G C+ D +EC PC H C N G+Y C C G + D
Sbjct: 5086 GDRSNQCPSGFTLDSVGPFCA-DEDECAAG-NPCSHSCHNAMGTYYCSCPKGLTIAADGR 5143
Query: 131 TCVNSRTCAM----INCQYSCEDTEEGPQCLCP-SSGLRLAPNGRDCLDIDECASGKVIC 185
TC + CA+ + C++T +C+ SG R +G C DI+EC
Sbjct: 5144 TCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINECQESS--- 5200
Query: 186 PYNRRCVNTFGSYYCKCHIGFELQ----------------------YISGRYDCID---- 219
P ++RC N GS++C C G++L+ G Y CID
Sbjct: 5201 PCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPN 5260
Query: 220 ------------INECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGL--------RCS 259
I+EC +H C ++ C NT+GS++C C +GY+ G+ C
Sbjct: 5261 GMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECE 5320
Query: 260 AIPENSVKEVLRAPGTIK 277
+P+ + PG+ K
Sbjct: 5321 QVPKPCAHQCSNTPGSFK 5338
Score = 94.7 bits (234), Expect = 2e-19
Identities = 72/247 (29%), Positives = 102/247 (41%), Gaps = 56/247 (22%)
Query: 49 CCYGWRRNSKGVCEAT--CEPG---CKFGECV----GPNKCRCFPGY----TGKTCSQDV 95
C G + G C C+ G C++ + G +C C GY G+ C D+
Sbjct: 5258 CPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPC-MDI 5316
Query: 96 NECGMKPRPCQHRCVNTHGSYKCFCLSG-HMLMPDATCVNSRTCAMINCQYS-------- 146
NEC P+PC H+C NT GS+KC C G H+L +C QYS
Sbjct: 5317 NECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPNYGTQYSSYNLARFS 5376
Query: 147 -CEDTEEGPQCLCPSSGL----------------------RLAPNGRD-----CLDIDEC 178
+ + Q S L + P G + C+DIDEC
Sbjct: 5377 PVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDEC 5436
Query: 179 ASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFN 238
+ C NTFGSY C C G++L + +G+ C DI+EC + C + CFN
Sbjct: 5437 ENTDAC---QHECKNTFGSYQCICPPGYQLTH-NGK-TCQDIDECLEQNVHCGPNRMCFN 5491
Query: 239 TQGSFKC 245
+GS++C
Sbjct: 5492 MRGSYQC 5498
Score = 65.5 bits (158), Expect = 1e-10
Identities = 35/87 (40%), Positives = 46/87 (52%), Gaps = 5/87 (5%)
Query: 131 TCVNSRTCAMIN-CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNR 189
TCV+ C + CQ+ C++T QC+CP G +L NG+ C DIDEC V C NR
Sbjct: 5429 TCVDIDECENTDACQHECKNTFGSYQCICPP-GYQLTHNGKTCQDIDECLEQNVHCGPNR 5487
Query: 190 RCVNTFGSYYC---KCHIGFELQYISG 213
C N GSY C C ++ +SG
Sbjct: 5488 MCFNMRGSYQCIDTPCPPNYQRDPVSG 5514
>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
Length = 955
Score = 128 bits (321), Expect = 2e-29
Identities = 78/236 (33%), Positives = 103/236 (43%), Gaps = 21/236 (8%)
Query: 38 PGVCHYGTKLACCYGWRRNSKG--VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDV 95
P VC G CC GW + G C GC G C+ PN C C G G TC +
Sbjct: 42 PHVCLSGFGSGCCPGWAPSMGGGHCTLPLCSFGCGSGICIAPNVCSCQDGEQGATCPETH 101
Query: 96 NECGMKPRPCQHRCVNTHGSYK---CFCLSGHMLMPDAT---CVNSRTCAMINCQYSCED 149
CG C C HG + C G + A C + C +C+ C +
Sbjct: 102 GPCG--EYGCDLTC--NHGGCQEVARVCPVGFSMTETAVGIRCTDIDECVTSSCEGHCVN 157
Query: 150 TEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQ 209
TE G C C G++L+ + C D DEC P +RC N+ GSY C C GF L
Sbjct: 158 TEGGFVCEC-GPGMQLSADRHSCQDTDECLG----TPCQQRCKNSIGSYKCSCRTGFHLH 212
Query: 210 YISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY--KGNGLRCSAIPE 263
R+ C+D+NEC H +C NT GSF C C+ G+ + + + C A P+
Sbjct: 213 --GNRHSCVDVNECRRPLERRVCHHSCHNTVGSFLCTCRPGFRLRADRVSCEAFPK 266
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 127 bits (318), Expect = 3e-29
Identities = 86/246 (34%), Positives = 112/246 (45%), Gaps = 24/246 (9%)
Query: 49 CCYGWRRNSKGV-------CEATCEPGCKFGECV---GPNKCRCFPGYTGKTCSQ---DV 95
C G+ N +G C EP K CV G +C C GY S+ DV
Sbjct: 341 CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
Query: 96 NECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMINCQYSCEDTEEG 153
NEC P R C H+C NT GSY C C G L D +C + C+ C C +
Sbjct: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGS 460
Query: 154 PQCLCPSSGLRLAPNGRDCLDIDECA--SGKVICPYNRRCVNTFGSYYCKCHIGFELQYI 211
QC C +G C DIDECA +G IC Y RC+N GS+ C C
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAP 518
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGYKGN-GLRCSAIPENSVK 267
+GR +C DI+EC H CS + CFN QG F+C +C + Y+ + RC +P + +
Sbjct: 519 NGR-NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENR 577
Query: 268 EVLRAP 273
E + P
Sbjct: 578 ECSKLP 583
Score = 111 bits (277), Expect = 2e-24
Identities = 73/220 (33%), Positives = 107/220 (48%), Gaps = 31/220 (14%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQ--HRCVNTHGSYKC----FCLSGHMLMPD 129
C CF GY G +C +DVNEC C+ C+NT GS++C C +G+ L D
Sbjct: 199 CSCFVGYQLLSDGVSC-EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED 257
Query: 130 ATCVNSRTC--AMINC--QYSCEDTEEG----PQCLCPSSGLRLAPNGRDCLDIDECASG 181
+C + C + NC + C++T P+ C S ++ A +C+DI+EC S
Sbjct: 258 NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG--NCIDINECLSI 315
Query: 182 KVICPYNRRCVNTFGSYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANC 236
CP C+NT GSY C+ C G+ L R C+D++EC + C C
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR--CVDVDECAPPAEPCGKGHRC 373
Query: 237 FNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTI 276
N+ GSF+C+CK GY +G+ + V E R PG +
Sbjct: 374 VNSPGSFRCECKTGYYFDGISRMCV---DVNECQRYPGRL 410
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 121 bits (304), Expect = 1e-27
Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 23/224 (10%)
Query: 49 CCYGWRRNSKGV-------CEATCEPGCKFGECV---GPNKCRCFPGYTGKTCSQ---DV 95
C G+ N +G C EP K CV G +C C GY S+ DV
Sbjct: 341 CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
Query: 96 NECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMINCQYSCEDTEEG 153
NEC P R C H+C NT GSY C C G L D +C + C+ C C +
Sbjct: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGS 460
Query: 154 PQCLCPSSGLRLAPNGRDCLDIDECA--SGKVICPYNRRCVNTFGSYYCKCHIGFELQYI 211
QC C +G C DIDECA +G IC Y RC+N GS+ C C
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAP 518
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGYK 252
+GR +C DI+EC H CS + CFN QG F+C +C + Y+
Sbjct: 519 NGR-NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Score = 111 bits (277), Expect = 2e-24
Identities = 73/220 (33%), Positives = 107/220 (48%), Gaps = 31/220 (14%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQ--HRCVNTHGSYKC----FCLSGHMLMPD 129
C CF GY G +C +DVNEC C+ C+NT GS++C C +G+ L D
Sbjct: 199 CSCFVGYQLLSDGVSC-EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED 257
Query: 130 ATCVNSRTC--AMINC--QYSCEDTEEG----PQCLCPSSGLRLAPNGRDCLDIDECASG 181
+C + C + NC + C++T P+ C S ++ A +C+DI+EC S
Sbjct: 258 NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG--NCIDINECLSI 315
Query: 182 KVICPYNRRCVNTFGSYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANC 236
CP C+NT GSY C+ C G+ L R C+D++EC + C C
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR--CVDVDECAPPAEPCGKGHRC 373
Query: 237 FNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTI 276
N+ GSF+C+CK GY +G+ + V E R PG +
Sbjct: 374 VNSPGSFRCECKTGYYFDGISRMCV---DVNECQRYPGRL 410
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 121 bits (304), Expect = 1e-27
Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 23/224 (10%)
Query: 49 CCYGWRRNSKGV-------CEATCEPGCKFGECV---GPNKCRCFPGYTGKTCSQ---DV 95
C G+ N +G C EP K CV G +C C GY S+ DV
Sbjct: 341 CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
Query: 96 NECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMINCQYSCEDTEEG 153
NEC P R C H+C NT GSY C C G L D +C + C+ C C +
Sbjct: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGS 460
Query: 154 PQCLCPSSGLRLAPNGRDCLDIDECA--SGKVICPYNRRCVNTFGSYYCKCHIGFELQYI 211
QC C +G C DIDECA +G IC Y RC+N GS+ C C
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAP 518
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGYK 252
+GR +C DI+EC H CS + CFN QG F+C +C + Y+
Sbjct: 519 NGR-NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Score = 111 bits (277), Expect = 2e-24
Identities = 73/220 (33%), Positives = 107/220 (48%), Gaps = 31/220 (14%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQ--HRCVNTHGSYKC----FCLSGHMLMPD 129
C CF GY G +C +DVNEC C+ C+NT GS++C C +G+ L D
Sbjct: 199 CSCFVGYQLLSDGVSC-EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED 257
Query: 130 ATCVNSRTC--AMINC--QYSCEDTEEG----PQCLCPSSGLRLAPNGRDCLDIDECASG 181
+C + C + NC + C++T P+ C S ++ A +C+DI+EC S
Sbjct: 258 NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG--NCIDINECLSI 315
Query: 182 KVICPYNRRCVNTFGSYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANC 236
CP C+NT GSY C+ C G+ L R C+D++EC + C C
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR--CVDVDECAPPAEPCGKGHRC 373
Query: 237 FNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTI 276
N+ GSF+C+CK GY +G+ + V E R PG +
Sbjct: 374 VNSPGSFRCECKTGYYFDGISRMCV---DVNECQRYPGRL 410
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 121 bits (304), Expect = 1e-27
Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 23/224 (10%)
Query: 49 CCYGWRRNSKGV-------CEATCEPGCKFGECV---GPNKCRCFPGYTGKTCSQ---DV 95
C G+ N +G C EP K CV G +C C GY S+ DV
Sbjct: 341 CGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDV 400
Query: 96 NECGMKP-RPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMINCQYSCEDTEEG 153
NEC P R C H+C NT GSY C C G L D +C + C+ C C +
Sbjct: 401 NECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGS 460
Query: 154 PQCLCPSSGLRLAPNGRDCLDIDECA--SGKVICPYNRRCVNTFGSYYCKCHIGFELQYI 211
QC C +G C DIDECA +G IC Y RC+N GS+ C C
Sbjct: 461 YQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSY--RCINIPGSFQCSCPSSGYRLAP 518
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC---KCKQGYK 252
+GR +C DI+EC H CS + CFN QG F+C +C + Y+
Sbjct: 519 NGR-NCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYR 561
Score = 111 bits (277), Expect = 2e-24
Identities = 73/220 (33%), Positives = 107/220 (48%), Gaps = 31/220 (14%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQ--HRCVNTHGSYKC----FCLSGHMLMPD 129
C CF GY G +C +DVNEC C+ C+NT GS++C C +G+ L D
Sbjct: 199 CSCFVGYQLLSDGVSC-EDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTED 257
Query: 130 ATCVNSRTC--AMINC--QYSCEDTEEG----PQCLCPSSGLRLAPNGRDCLDIDECASG 181
+C + C + NC + C++T P+ C S ++ A +C+DI+EC S
Sbjct: 258 NSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALG--NCIDINECLSI 315
Query: 182 KVICPYNRRCVNTFGSYYCK-----CHIGFELQYISGRYDCIDINECTMDSHTCSHHANC 236
CP C+NT GSY C+ C G+ L R C+D++EC + C C
Sbjct: 316 SAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTR--CVDVDECAPPAEPCGKGHRC 373
Query: 237 FNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGTI 276
N+ GSF+C+CK GY +G+ + V E R PG +
Sbjct: 374 VNSPGSFRCECKTGYYFDGISRMCV---DVNECQRYPGRL 410
>gi|62548862 matrilin 2 isoform b precursor [Homo sapiens]
Length = 937
Score = 119 bits (297), Expect = 9e-27
Identities = 66/179 (36%), Positives = 87/179 (48%), Gaps = 15/179 (8%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVN 134
C+C+ GY GK C V+ C + C+H CVN GSY C C G L PD TC
Sbjct: 303 CQCYSGYALAEDGKRCVA-VDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 135 SRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCV 192
CA N CQ+ C +T++ C C G L P+ + C I+ CA K C + CV
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHC-LKGFTLNPDKKTCRRINYCALNKPGCEH--ECV 418
Query: 193 NTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
N SYYC+CH G+ L C ++ C H C C NT+ SF C+C +G+
Sbjct: 419 NMEESYYCRCHRGYTLD--PNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
Score = 116 bits (290), Expect = 6e-26
Identities = 70/206 (33%), Positives = 100/206 (48%), Gaps = 21/206 (10%)
Query: 68 GCKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
GC+ ECV G C+C G+ KTC++ ++ C CQH CVNT SY C C
Sbjct: 330 GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTK-IDYCASSNHGCQHECVNTDDSYSCHC 387
Query: 121 LSGHMLMPD-ATCVNSRTCAM--INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
L G L PD TC CA+ C++ C + EE C C G L PNG+ C +D
Sbjct: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDH 446
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCF 237
CA C + C+NT S+ C+C GF + C ++ C + H C + +C
Sbjct: 447 CAQQDHGC--EQLCLNTEDSFVCQCSEGFLIN--EDLKTCSRVDYCLLSDHGCEY--SCV 500
Query: 238 NTQGSFKCKCKQGY--KGNGLRCSAI 261
N SF C+C +G+ + +G C+ +
Sbjct: 501 NMDRSFACQCPEGHVLRSDGKTCAKL 526
Score = 109 bits (273), Expect = 6e-24
Identities = 69/205 (33%), Positives = 105/205 (51%), Gaps = 21/205 (10%)
Query: 66 EPGCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKC 118
+PGC+ ECV + CRC GYT GKTCS+ V+ C + C+ C+NT S+ C
Sbjct: 410 KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVC 467
Query: 119 FCLSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
C G ++ D TC C + + C+YSC + + C CP G L +G+ C +
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE-GHVLRSDGKTCAKL 526
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
D CA G C ++ CV++ S+ C+C G+ L+ G+ C + C H C H
Sbjct: 527 DSCALGDHGCEHS--CVSSEDSFVCQCFEGYILRE-DGK-TCRRKDVCQAIDHGCEHI-- 580
Query: 236 CFNTQGSFKCKCKQGYK--GNGLRC 258
C N+ S+ C+C +G++ +G RC
Sbjct: 581 CVNSDDSYTCECLEGFRLAEDGKRC 605
Score = 108 bits (270), Expect = 1e-23
Identities = 68/194 (35%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 76 GPNKCRCFPGY---TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-T 131
G CRC GY + +T + + C M+ C+ CVN GS+ C C SG+ L D
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKR 317
Query: 132 CVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNR 189
CV CA N C++ C + + C C G L P+ + C ID CAS C +
Sbjct: 318 CVAVDYCASENHGCEHECVNADGSYLCQC-HEGFALNPDKKTCTKIDYCASSNHGCQH-- 374
Query: 190 RCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
CVNT SY C C GF L + C IN C ++ C H C N + S+ C+C +
Sbjct: 375 ECVNTDDSYSCHCLKGFTLN--PDKKTCRRINYCALNKPGCEH--ECVNMEESYYCRCHR 430
Query: 250 GY--KGNGLRCSAI 261
GY NG CS +
Sbjct: 431 GYTLDPNGKTCSRV 444
Score = 105 bits (262), Expect = 1e-22
Identities = 60/160 (37%), Positives = 77/160 (48%), Gaps = 10/160 (6%)
Query: 98 CGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCAM--INCQYSCEDTEEGP 154
C C H C+N GSY C C G++L D TC CAM NC+ C +
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 155 QCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGR 214
C C SG LA +G+ C+ +D CAS C + CVN GSY C+CH GF L +
Sbjct: 302 VCQC-YSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALN--PDK 356
Query: 215 YDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN 254
C I+ C +H C H C NT S+ C C +G+ N
Sbjct: 357 KTCTKIDYCASSNHGCQH--ECVNTDDSYSCHCLKGFTLN 394
Score = 85.1 bits (209), Expect = 2e-16
Identities = 51/151 (33%), Positives = 78/151 (51%), Gaps = 15/151 (9%)
Query: 68 GCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
GC++ CV ++ C+C G+ GKTC++ ++ C + C+H CV++ S+ C C
Sbjct: 494 GCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAK-LDSCALGDHGCEHSCVSSEDSFVCQC 551
Query: 121 LSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
G++L D TC C I+ C++ C ++++ C C G RLA +G+ C D
Sbjct: 552 FEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDV 610
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
C S C + CVN SY CKC GF L
Sbjct: 611 CKSTHHGCEH--ICVNNGNSYICKCSEGFVL 639
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/79 (34%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 58 KGVCEATCEPGCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCV 110
K VC+A + GC+ CV + C C G+ GK C + + C C+H CV
Sbjct: 567 KDVCQAI-DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-DVCKSTHHGCEHICV 623
Query: 111 NTHGSYKCFCLSGHMLMPD 129
N SY C C G +L D
Sbjct: 624 NNGNSYICKCSEGFVLAED 642
>gi|62548860 matrilin 2 isoform a precursor [Homo sapiens]
Length = 956
Score = 119 bits (297), Expect = 9e-27
Identities = 66/179 (36%), Positives = 87/179 (48%), Gaps = 15/179 (8%)
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVN 134
C+C+ GY GK C V+ C + C+H CVN GSY C C G L PD TC
Sbjct: 303 CQCYSGYALAEDGKRCVA-VDYCASENHGCEHECVNADGSYLCQCHEGFALNPDKKTCTK 361
Query: 135 SRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCV 192
CA N CQ+ C +T++ C C G L P+ + C I+ CA K C + CV
Sbjct: 362 IDYCASSNHGCQHECVNTDDSYSCHC-LKGFTLNPDKKTCRRINYCALNKPGCEH--ECV 418
Query: 193 NTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
N SYYC+CH G+ L C ++ C H C C NT+ SF C+C +G+
Sbjct: 419 NMEESYYCRCHRGYTLD--PNGKTCSRVDHCAQQDHGCEQ--LCLNTEDSFVCQCSEGF 473
Score = 116 bits (290), Expect = 6e-26
Identities = 70/206 (33%), Positives = 100/206 (48%), Gaps = 21/206 (10%)
Query: 68 GCKFGECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
GC+ ECV G C+C G+ KTC++ ++ C CQH CVNT SY C C
Sbjct: 330 GCEH-ECVNADGSYLCQCHEGFALNPDKKTCTK-IDYCASSNHGCQHECVNTDDSYSCHC 387
Query: 121 LSGHMLMPD-ATCVNSRTCAM--INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
L G L PD TC CA+ C++ C + EE C C G L PNG+ C +D
Sbjct: 388 LKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEESYYCRC-HRGYTLDPNGKTCSRVDH 446
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCF 237
CA C + C+NT S+ C+C GF + C ++ C + H C + +C
Sbjct: 447 CAQQDHGC--EQLCLNTEDSFVCQCSEGFLIN--EDLKTCSRVDYCLLSDHGCEY--SCV 500
Query: 238 NTQGSFKCKCKQGY--KGNGLRCSAI 261
N SF C+C +G+ + +G C+ +
Sbjct: 501 NMDRSFACQCPEGHVLRSDGKTCAKL 526
Score = 109 bits (273), Expect = 6e-24
Identities = 69/205 (33%), Positives = 105/205 (51%), Gaps = 21/205 (10%)
Query: 66 EPGCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKC 118
+PGC+ ECV + CRC GYT GKTCS+ V+ C + C+ C+NT S+ C
Sbjct: 410 KPGCEH-ECVNMEESYYCRCHRGYTLDPNGKTCSR-VDHCAQQDHGCEQLCLNTEDSFVC 467
Query: 119 FCLSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
C G ++ D TC C + + C+YSC + + C CP G L +G+ C +
Sbjct: 468 QCSEGFLINEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPE-GHVLRSDGKTCAKL 526
Query: 176 DECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHAN 235
D CA G C ++ CV++ S+ C+C G+ L+ G+ C + C H C H
Sbjct: 527 DSCALGDHGCEHS--CVSSEDSFVCQCFEGYILRE-DGK-TCRRKDVCQAIDHGCEHI-- 580
Query: 236 CFNTQGSFKCKCKQGYK--GNGLRC 258
C N+ S+ C+C +G++ +G RC
Sbjct: 581 CVNSDDSYTCECLEGFRLAEDGKRC 605
Score = 108 bits (270), Expect = 1e-23
Identities = 68/194 (35%), Positives = 91/194 (46%), Gaps = 15/194 (7%)
Query: 76 GPNKCRCFPGY---TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-T 131
G CRC GY + +T + + C M+ C+ CVN GS+ C C SG+ L D
Sbjct: 258 GSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALAEDGKR 317
Query: 132 CVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNR 189
CV CA N C++ C + + C C G L P+ + C ID CAS C +
Sbjct: 318 CVAVDYCASENHGCEHECVNADGSYLCQC-HEGFALNPDKKTCTKIDYCASSNHGCQH-- 374
Query: 190 RCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
CVNT SY C C GF L + C IN C ++ C H C N + S+ C+C +
Sbjct: 375 ECVNTDDSYSCHCLKGFTLN--PDKKTCRRINYCALNKPGCEH--ECVNMEESYYCRCHR 430
Query: 250 GY--KGNGLRCSAI 261
GY NG CS +
Sbjct: 431 GYTLDPNGKTCSRV 444
Score = 105 bits (262), Expect = 1e-22
Identities = 60/160 (37%), Positives = 77/160 (48%), Gaps = 10/160 (6%)
Query: 98 CGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCAM--INCQYSCEDTEEGP 154
C C H C+N GSY C C G++L D TC CAM NC+ C +
Sbjct: 242 CSTLEHNCAHFCINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSF 301
Query: 155 QCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGR 214
C C SG LA +G+ C+ +D CAS C + CVN GSY C+CH GF L +
Sbjct: 302 VCQC-YSGYALAEDGKRCVAVDYCASENHGCEH--ECVNADGSYLCQCHEGFALN--PDK 356
Query: 215 YDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGN 254
C I+ C +H C H C NT S+ C C +G+ N
Sbjct: 357 KTCTKIDYCASSNHGCQH--ECVNTDDSYSCHCLKGFTLN 394
Score = 85.1 bits (209), Expect = 2e-16
Identities = 51/151 (33%), Positives = 78/151 (51%), Gaps = 15/151 (9%)
Query: 68 GCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFC 120
GC++ CV ++ C+C G+ GKTC++ ++ C + C+H CV++ S+ C C
Sbjct: 494 GCEYS-CVNMDRSFACQCPEGHVLRSDGKTCAK-LDSCALGDHGCEHSCVSSEDSFVCQC 551
Query: 121 LSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
G++L D TC C I+ C++ C ++++ C C G RLA +G+ C D
Sbjct: 552 FEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCEC-LEGFRLAEDGKRCRRKDV 610
Query: 178 CASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
C S C + CVN SY CKC GF L
Sbjct: 611 CKSTHHGCEH--ICVNNGNSYICKCSEGFVL 639
Score = 40.0 bits (92), Expect = 0.006
Identities = 27/79 (34%), Positives = 36/79 (45%), Gaps = 10/79 (12%)
Query: 58 KGVCEATCEPGCKFGECVGPNK---CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCV 110
K VC+A + GC+ CV + C C G+ GK C + + C C+H CV
Sbjct: 567 KDVCQAI-DHGCEH-ICVNSDDSYTCECLEGFRLAEDGKRCRRK-DVCKSTHHGCEHICV 623
Query: 111 NTHGSYKCFCLSGHMLMPD 129
N SY C C G +L D
Sbjct: 624 NNGNSYICKCSEGFVLAED 642
>gi|190343004 EGF-containing fibulin-like extracellular matrix
protein 2 [Homo sapiens]
Length = 443
Score = 118 bits (295), Expect = 2e-26
Identities = 64/180 (35%), Positives = 91/180 (50%), Gaps = 15/180 (8%)
Query: 77 PNKCRCFPGYT--GKTCSQDVNECGMKPRPCQ--HRCVNTHGSYKCFCLSGHMLMPDATC 132
PN C PGY + DV+EC C+ C N GSY+C C G+ + C
Sbjct: 106 PNPCP--PGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI-GPEC 162
Query: 133 VNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCV 192
V+ C CQ+ C + +C C G +L PN R C+D++EC G P +RC
Sbjct: 163 VDIDECRYRYCQHRCVNLPGSFRCQC-EPGFQLGPNNRSCVDVNECDMG---APCEQRCF 218
Query: 193 NTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
N++G++ C+CH G+EL + C DI+EC+ S+ C + C N G F C C QGY+
Sbjct: 219 NSYGTFLCRCHQGYELH--RDGFSCSDIDECSYSSYLCQYR--CVNEPGRFSCHCPQGYQ 274
Score = 111 bits (277), Expect = 2e-24
Identities = 70/195 (35%), Positives = 96/195 (49%), Gaps = 17/195 (8%)
Query: 65 CEPGCKFGECVGPNKCRCFPGYT--GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLS 122
C P G +C C GY G C D++EC + R CQHRCVN GS++C C
Sbjct: 134 CRPSQDCHNLPGSYQCTCPDGYRKIGPECV-DIDEC--RYRYCQHRCVNLPGSFRCQCEP 190
Query: 123 GHMLMP-DATCVNSRTCAM-INCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS 180
G L P + +CV+ C M C+ C ++ C C G L +G C DIDEC+
Sbjct: 191 GFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRC-HQGYELHRDGFSCSDIDECSY 249
Query: 181 GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
+C Y RCVN G + C C G++L ++ R C DI+EC +H CS C N
Sbjct: 250 SSYLCQY--RCVNEPGRFSCHCPQGYQL--LATRL-CQDIDECESGAHQCSEAQTCVNFH 304
Query: 241 GSFKC----KCKQGY 251
G ++C +C + Y
Sbjct: 305 GGYRCVDTNRCVEPY 319
Score = 98.2 bits (243), Expect = 2e-20
Identities = 73/227 (32%), Positives = 99/227 (43%), Gaps = 50/227 (22%)
Query: 82 CFPGYTGKTCSQ---DVNECGMKPRPC--QHRCVNTHGSYKCF----------------- 119
C GY SQ DVNEC P C + +C+N +G Y C
Sbjct: 39 CTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPP 98
Query: 120 ----------CLSGHMLMPDATCVNSRTCAMI--NCQYS--CEDTEEGPQCLCPSSGLRL 165
C G+ +CV+ CA +C+ S C + QC CP ++
Sbjct: 99 PVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKI 158
Query: 166 APNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTM 225
P +C+DIDEC C + RCVN GS+ C+C GF+L C+D+NEC M
Sbjct: 159 GP---ECVDIDECRYR--YCQH--RCVNLPGSFRCQCEPGFQLG--PNNRSCVDVNECDM 209
Query: 226 DSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRCSAIPENSVKEVL 270
+ C CFN+ G+F C+C QGY+ +G CS I E S L
Sbjct: 210 GA-PCEQR--CFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYL 253
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/145 (25%), Positives = 57/145 (39%), Gaps = 30/145 (20%)
Query: 146 SCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYC----- 200
S +D+EE + G P+ + C D++EC + C +C+N +G Y C
Sbjct: 26 SPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSA 85
Query: 201 ----------------------KCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFN 238
C G+E + C+D++EC H C +C N
Sbjct: 86 AVINDLHGEGPPPPVPPAQHPNPCPPGYE---PDDQDSCVDVDECAQALHDCRPSQDCHN 142
Query: 239 TQGSFKCKCKQGYKGNGLRCSAIPE 263
GS++C C GY+ G C I E
Sbjct: 143 LPGSYQCTCPDGYRKIGPECVDIDE 167
Score = 60.8 bits (146), Expect = 3e-09
Identities = 44/155 (28%), Positives = 59/155 (38%), Gaps = 50/155 (32%)
Query: 56 NSKGVCEATCEPGCKFG----ECVGPNKC-------------------RCFPGYT----G 88
N G CEPG + G CV N+C RC GY G
Sbjct: 179 NLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDG 238
Query: 89 KTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVN-------------S 135
+CS D++EC CQ+RCVN G + C C G+ L+ C + +
Sbjct: 239 FSCS-DIDECSYSSYLCQYRCVNEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEA 297
Query: 136 RTCAMINCQYSCEDTE---------EGPQCLCPSS 161
+TC + Y C DT +CLCP+S
Sbjct: 298 QTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPAS 332
>gi|4557733 latent transforming growth factor beta binding protein 2
[Homo sapiens]
Length = 1821
Score = 115 bits (289), Expect = 8e-26
Identities = 89/243 (36%), Positives = 118/243 (48%), Gaps = 35/243 (14%)
Query: 38 PGVCHYG--TKLA-------CCYGWRRNSKG-VCEAT--CEP---GCKFGEC---VGPNK 79
PGVC G T A C G+R + G CE CE C GEC VG +
Sbjct: 1100 PGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSCLGGECKNTVGSYQ 1159
Query: 80 CRCFPGY---TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYKCFCLSGHMLMPDAT-CVN 134
C C G+ G C +DVNEC + H C+N+HGS+ C C G + T C +
Sbjct: 1160 CLCPQGFQLANGTVC-EDVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
Query: 135 SRTCAMINCQYS--CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS-GKVICPYNRRC 191
CA + C +TE CLC +G + +P +C+DIDEC G +C +C
Sbjct: 1219 VDECATTDPCVGGHCVNTEGSFNCLC-ETGFQPSPESGECVDIDECEDYGDPVCG-TWKC 1276
Query: 192 VNTFGSYYCK--CHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
N+ GSY C C GF +++ DCIDI+EC D+ C H C NT GSF+C C Q
Sbjct: 1277 ENSPGSYRCVLGCQPGF---HMAPNGDCIDIDECANDT-MCGSHGFCDNTDGSFRCLCDQ 1332
Query: 250 GYK 252
G++
Sbjct: 1333 GFE 1335
Score = 114 bits (286), Expect = 2e-25
Identities = 89/254 (35%), Positives = 112/254 (44%), Gaps = 33/254 (12%)
Query: 36 RQPGVCHYG---------TKLACCYGWRRNSKGVCEATCE---PG-CKFGECV---GPNK 79
R PG C G T LAC G+R S G C E PG C G+C G +
Sbjct: 975 RHPGTCPDGRCVNSPGSYTCLACEEGYRGQS-GSCVDVNECLTPGVCAHGKCTNLEGSFR 1033
Query: 80 CRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNTHGSYKC-FCLSGHMLMPDAT-CV 133
C C GY K C QDV+EC + C+NT GS+ C C +G+ + D T C
Sbjct: 1034 CSCEQGYEVTSDEKGC-QDVDECASRASCPTGLCLNTEGSFACSACENGYWVNEDGTACE 1092
Query: 134 NSRTCAMINCQYS--CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRC 191
+ CA S C +T C G R +P G C D+DEC + C C
Sbjct: 1093 DLDECAFPGVCPSGVCTNTAGSFSCKDCDGGYRPSPLGDSCEDVDECEDPQSSC-LGGEC 1151
Query: 192 VNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
NT GSY C C GF+L + C D+NEC + H C+ H C N+ GSF C C G+
Sbjct: 1152 KNTVGSYQCLCPQGFQL---ANGTVCEDVNECMGEEH-CAPHGECLNSHGSFFCLCAPGF 1207
Query: 252 KG--NGLRCSAIPE 263
G C + E
Sbjct: 1208 VSAEGGTSCQDVDE 1221
Score = 114 bits (286), Expect = 2e-25
Identities = 78/219 (35%), Positives = 106/219 (48%), Gaps = 28/219 (12%)
Query: 49 CCYGWRRNSKGVCEAT--------CEPGCKFGECV---GPNKCRCFPGYT---GKTCSQD 94
C G++ + VCE C P GEC+ G C C PG+ G T QD
Sbjct: 1162 CPQGFQLANGTVCEDVNECMGEEHCAP---HGECLNSHGSFFCLCAPGFVSAEGGTSCQD 1218
Query: 95 VNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCA----MINCQYSCED 149
V+EC CVNT GS+ C C +G P++ CV+ C + + CE+
Sbjct: 1219 VDECATTDPCVGGHCVNTEGSFNCLCETGFQPSPESGECVDIDECEDYGDPVCGTWKCEN 1278
Query: 150 TEEGPQC-LCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFEL 208
+ +C L G +APNG DC+DIDECA+ +C + C NT GS+ C C GFE+
Sbjct: 1279 SPGSYRCVLGCQPGFHMAPNG-DCIDIDECAN-DTMCGSHGFCDNTDGSFRCLCDQGFEI 1336
Query: 209 QYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
+DC+D+NEC + C A C N +GSF C C
Sbjct: 1337 S--PSGWDCVDVNECELMLAVCG-AALCENVEGSFLCLC 1372
Score = 104 bits (260), Expect = 2e-22
Identities = 78/207 (37%), Positives = 101/207 (48%), Gaps = 28/207 (13%)
Query: 61 CEATCEPGCKFGECVG-PN--KCRCFPGYT---GKTCSQDVNECGMKPRPCQHRCVNTHG 114
C A C G CV P+ +C C PGY + D NEC P + RC+N G
Sbjct: 848 CAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDDNECLRDPCKGKGRCINRVG 907
Query: 115 SYKCFCLSGHMLMPDATCVNSRTCAMIN-CQY-------SCEDTEEGPQCLCPSSGLRLA 166
SY CFC G+ L AT ++ C IN C+ C +TE C C G +
Sbjct: 908 SYSCFCYPGYTL---ATSGATQECQDINECEQPGVCSGGQCTNTEGSYHCEC-DQGYIMV 963
Query: 167 PNGRDCLDIDECASGKVICPYNRRCVNTFGSYYC-KCHIGFELQYISGRYDCIDINECTM 225
G C DI+EC CP + RCVN+ GSY C C G+ Q SG C+D+NEC +
Sbjct: 964 RKGH-CQDINECRHPGT-CP-DGRCVNSPGSYTCLACEEGYRGQ--SG--SCVDVNEC-L 1015
Query: 226 DSHTCSHHANCFNTQGSFKCKCKQGYK 252
C+ H C N +GSF+C C+QGY+
Sbjct: 1016 TPGVCA-HGKCTNLEGSFRCSCEQGYE 1041
Score = 79.7 bits (195), Expect = 6e-15
Identities = 51/137 (37%), Positives = 67/137 (48%), Gaps = 18/137 (13%)
Query: 146 SCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIG 205
+C + +G +C+C S G +L P+ C D +EC C RC+N GSY C C+ G
Sbjct: 860 TCVNLPDGYRCVC-SPGYQLHPSQAYCTDDNECLRDP--CKGKGRCINRVGSYSCFCYPG 916
Query: 206 FELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY----KGNGLRCSAI 261
+ L +C DINEC CS C NT+GS+ C+C QGY KG+ C I
Sbjct: 917 YTLATSGATQECQDINECEQPG-VCS-GGQCTNTEGSYHCECDQGYIMVRKGH---CQDI 971
Query: 262 PENSVKEVLRAPGTIKD 278
E R PGT D
Sbjct: 972 NE------CRHPGTCPD 982
Score = 59.7 bits (143), Expect = 7e-09
Identities = 76/290 (26%), Positives = 102/290 (35%), Gaps = 99/290 (34%)
Query: 50 CYGWR-RNSKGV--CEATCEPGCKF---GECV---------------------GPNKCRC 82
C W+ NS G C C+PG G+C+ G +C C
Sbjct: 1271 CGTWKCENSPGSYRCVLGCQPGFHMAPNGDCIDIDECANDTMCGSHGFCDNTDGSFRCLC 1330
Query: 83 FPGY----TGKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLS--------------- 122
G+ +G C DVNEC + C C N GS+ C C S
Sbjct: 1331 DQGFEISPSGWDCV-DVNECELMLAVCGAALCENVEGSFLCLCASDLEEYDAQEGHCRPR 1389
Query: 123 --GHMLMPDAT------------CVNSRT----CAMI----NCQYSCEDTEE---GPQC- 156
G M +A C + + C+ + Q C T+ G C
Sbjct: 1390 GAGGQSMSEAPTGDHAPAPTRMDCYSGQKGHAPCSSVLGRNTTQAECCCTQGASWGDACD 1449
Query: 157 LCPSSGL----RLAPNGRDCL--------------DIDECAS-GKVICPYNRRCVNTFGS 197
LCPS + P+G+ + D DEC G +CP N RC+NT
Sbjct: 1450 LCPSEDSAEFSEICPSGKGYIPVEGAWTFGQTMYTDADECVIFGPGLCP-NGRCLNTVPG 1508
Query: 198 YYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
Y C C+ GF Y + C D +EC + C NT+GSF C C
Sbjct: 1509 YVCLCNPGF--HYDASHKKCEDHDEC---QDLACENGECVNTEGSFHCFC 1553
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 167 PNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECT-- 224
P G + L +EC G + N RCV Y C C GF+L + C+D+NEC
Sbjct: 1726 PAGFEGLQAEEC--GILNGCENGRCVRVREGYTCDCFEGFQLD--AAHMACVDVNECDDL 1781
Query: 225 MDSHTCSHHANCFNTQGSFKCKCKQGY 251
H C NT+GS++C C GY
Sbjct: 1782 NGPAVLCVHGYCENTEGSYRCHCSPGY 1808
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/68 (38%), Positives = 32/68 (47%), Gaps = 10/68 (14%)
Query: 68 GCKFGECVGPNK---CRCFPGY---TGKTCSQDVNECGMKPRP---CQHR-CVNTHGSYK 117
GC+ G CV + C CF G+ DVNEC P C H C NT GSY+
Sbjct: 1742 GCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCENTEGSYR 1801
Query: 118 CFCLSGHM 125
C C G++
Sbjct: 1802 CHCSPGYV 1809
Score = 41.6 bits (96), Expect = 0.002
Identities = 25/63 (39%), Positives = 31/63 (49%), Gaps = 3/63 (4%)
Query: 82 CFPGYT--GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTC 138
C GY T QD+NEC CVNT GSY C C G ML P + CV+ +
Sbjct: 608 CPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAI 667
Query: 139 AMI 141
+M+
Sbjct: 668 SML 670
Score = 38.1 bits (87), Expect = 0.021
Identities = 30/94 (31%), Positives = 36/94 (38%), Gaps = 12/94 (12%)
Query: 152 EGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYI 211
E Q CP RL N C DI+EC + +C + CVNT GSY C C G L
Sbjct: 602 ENGQLECPQGYKRL--NLTHCQDINECLT-LGLCK-DAECVNTRGSYLCTCRPGLMLDPS 657
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKC 245
R C D C+ + G C
Sbjct: 658 RSR--------CVSDKAISMLQGLCYRSLGPGTC 683
Score = 37.7 bits (86), Expect = 0.028
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 3/58 (5%)
Query: 49 CCYGWRR-NSKGVC-EATCEPGCKF-GECVGPNKCRCFPGYTGKTCSQDVNECGMKPR 103
CC GW NS C + CEP C+ G C P C C G+ G C + + + P+
Sbjct: 173 CCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCVCRSGFRGARCEEVIPDEEFDPQ 230
Score = 36.6 bits (83), Expect = 0.062
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 13/79 (16%)
Query: 67 PG-CKFGECVGPNK---CRCFPGY----TGKTCSQDVNECGMKPRPCQH-RCVNTHGSYK 117
PG C G C+ C C PG+ + K C +D +EC + C++ CVNT GS+
Sbjct: 1494 PGLCPNGRCLNTVPGYVCLCNPGFHYDASHKKC-EDHDEC--QDLACENGECVNTEGSFH 1550
Query: 118 CFCLSGHML-MPDATCVNS 135
CFC L + C+NS
Sbjct: 1551 CFCSPPLTLDLSQQRCMNS 1569
Score = 34.3 bits (77), Expect = 0.31
Identities = 17/50 (34%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 217 CIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSV 266
C DINEC + C A C NT+GS+ C C+ G + R + + ++
Sbjct: 620 CQDINEC-LTLGLCKD-AECVNTRGSYLCTCRPGLMLDPSRSRCVSDKAI 667
Score = 33.9 bits (76), Expect = 0.40
Identities = 22/69 (31%), Positives = 28/69 (40%), Gaps = 7/69 (10%)
Query: 97 ECGMKPRPCQHRCVNTHGSYKCFCLSGHML-MPDATCVNSRTCAMIN-----CQYS-CED 149
ECG+ RCV Y C C G L CV+ C +N C + CE+
Sbjct: 1736 ECGILNGCENGRCVRVREGYTCDCFEGFQLDAAHMACVDVNECDDLNGPAVLCVHGYCEN 1795
Query: 150 TEEGPQCLC 158
TE +C C
Sbjct: 1796 TEGSYRCHC 1804
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 114 bits (286), Expect = 2e-25
Identities = 77/231 (33%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 49 CCYGWRRNSKGVCEATCEPG---------------------CKFGEC---VGPNKCRCFP 84
C G +N++G TC G C G+C G +C C
Sbjct: 1090 CVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQ 1149
Query: 85 GYT----GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDATCVNSRTC- 138
GY G C +D+NEC CQ C+NT GSY C C G L + TC + C
Sbjct: 1150 GYRASGLGDHC-EDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE 1208
Query: 139 --AMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFG 196
+ Q C +TE C+C G ++ +GR C DIDEC + V C + C NT G
Sbjct: 1209 HPGLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAG 1266
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
S+ C C+ GF+ C+D+NEC + S C A C N +GSF C C
Sbjct: 1267 SFRCLCYQGFQAP--QDGQGCVDVNECELLSGVCG-EAFCENVEGSFLCVC 1314
Score = 107 bits (267), Expect = 3e-23
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 19/206 (9%)
Query: 69 CKFGECV---GPNKCR-CFPGY--TGKTCSQDVNECGMKPRPC-QHRCVNTHGSYKCFCL 121
C G CV G +C C GY T + +D++EC + P C +CVN+ GSY+C
Sbjct: 968 CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPDEQCVNSPGSYQCVPC 1026
Query: 122 SGHMLMPDATCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECA 179
+ + C++ C N C + E C C G P+ + C DIDEC
Sbjct: 1027 TEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQ 1085
Query: 180 SGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNT 239
G + N +C NT GS+ C C G++L + + C DI+EC H C+H C NT
Sbjct: 1086 QGNLCV--NGQCKNTEGSFRCTCGQGYQLS--AAKDQCEDIDEC-QHRHLCAH-GQCRNT 1139
Query: 240 QGSFKCKCKQGYKGNGL--RCSAIPE 263
+GSF+C C QGY+ +GL C I E
Sbjct: 1140 EGSFQCVCDQGYRASGLGDHCEDINE 1165
Score = 100 bits (248), Expect = 5e-21
Identities = 78/267 (29%), Positives = 105/267 (39%), Gaps = 63/267 (23%)
Query: 52 GWRRNSKGVCEATCEPGCKFGECV---GPNKCRCFPGYTG----KTCSQDVNECGMKPRP 104
GW V E C G+C G C C GYT K C +D++EC
Sbjct: 1032 GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNLC 1090
Query: 105 CQHRCVNTHGSYKCFCLSGHMLMPDAT-------CVNSRTCAMINCQYSCEDTEEGPQCL 157
+C NT GS++C C G+ L C + CA C +TE QC+
Sbjct: 1091 VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA----HGQCRNTEGSFQCV 1146
Query: 158 CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQ-------- 209
C G R + G C DI+EC K +C C+NT GSY C C GF+L
Sbjct: 1147 C-DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDI 1204
Query: 210 ----------------YISGRYDCI---------------DINECTMDSHTCSHHANCFN 238
G + C+ DI+EC +++ C H C N
Sbjct: 1205 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDN 1263
Query: 239 TQGSFKCKCKQGYKG--NGLRCSAIPE 263
T GSF+C C QG++ +G C + E
Sbjct: 1264 TAGSFRCLCYQGFQAPQDGQGCVDVNE 1290
Score = 96.3 bits (238), Expect = 7e-20
Identities = 67/202 (33%), Positives = 98/202 (48%), Gaps = 21/202 (10%)
Query: 62 EATCEPG-CKFGECVG---PNKCRCFPGYTGKTCSQ---DVNECGMKPRPC-QHRCVNTH 113
E T P C G C+ C C+ GY + D++EC C Q RC NT
Sbjct: 877 ECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTE 936
Query: 114 GSYKCFCLSGHMLMPDAT-CVNSRTCAM--INCQYSCEDTEEGPQCLCPSSGLRLAPNGR 170
GS+ C C +G M + T C++ C + + C +T +C SG R+ GR
Sbjct: 937 GSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGR 996
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYC-KCHIGFELQYISGRYDCIDINECTMDSHT 229
C DIDEC + CP + +CVN+ GSY C C GF C+D++EC ++ +
Sbjct: 997 -CEDIDECLNPST-CP-DEQCVNSPGSYQCVPCTEGFR----GWNGQCLDVDEC-LEPNV 1048
Query: 230 CSHHANCFNTQGSFKCKCKQGY 251
C+ + +C N +GS+ C C +GY
Sbjct: 1049 CA-NGDCSNLEGSYMCSCHKGY 1069
Score = 59.7 bits (143), Expect = 7e-09
Identities = 63/256 (24%), Positives = 96/256 (37%), Gaps = 65/256 (25%)
Query: 72 GECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSG 123
GEC+ G C C G++ G+TC +D++EC H C NT GS++C C G
Sbjct: 1217 GECLNTEGSFHCVCQQGFSISADGRTC-EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQG 1275
Query: 124 HMLMPDAT-CVNSRTCAMIN--C-QYSCEDTEEGPQCLCPSSGLRLAPNGRDC------- 172
D CV+ C +++ C + CE+ E C+C +P C
Sbjct: 1276 FQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTD 1335
Query: 173 --LDIDECASGKVICPYN-----------------RRCVNTFGSYY-------------- 199
+D+D+ K C YN + C T G+ +
Sbjct: 1336 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGT 1395
Query: 200 ------CKCHIGF----ELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
C GF E +G + D +EC + + C NT+ ++C CKQ
Sbjct: 1396 AEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQ 1455
Query: 250 G--YKGNGLRCSAIPE 263
G Y L+C + E
Sbjct: 1456 GTYYDPVKLQCFDMDE 1471
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/254 (24%), Positives = 85/254 (33%), Gaps = 77/254 (30%)
Query: 56 NSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQ---DVNECGMKPRPCQHR-CVN 111
+S G C+ T G +C C+ G+ Q DVNEC + C C N
Sbjct: 1256 DSHGFCDNTA----------GSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCEN 1305
Query: 112 THGSYKCFCLSGHM-LMPDATCVNSRTCAMIN------------CQYSCEDTE------- 151
GS+ C C + P SRT ++ C Y+ D
Sbjct: 1306 VEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLA 1365
Query: 152 ---EGPQCLCPSSG-------------------LRLAPNGRDCL---------------D 174
+C C S + P G+ + D
Sbjct: 1366 PNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1425
Query: 175 IDECAS-GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHH 233
DEC G+ IC N C+NT Y C C G Y + C D++EC D +C
Sbjct: 1426 ADECLLFGQEICK-NGFCLNTRPGYECYCKQG--TYYDPVKLQCFDMDEC-QDPSSCID- 1480
Query: 234 ANCFNTQGSFKCKC 247
C NT+GS+ C C
Sbjct: 1481 GQCVNTEGSYNCFC 1494
Score = 54.3 bits (129), Expect = 3e-07
Identities = 26/66 (39%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 188 NRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCS--HHANCFNTQGSFKC 245
N RCV Y C C G+ L + + C+D+NEC ++ S +A C NT GS+KC
Sbjct: 1634 NGRCVRVQEGYTCDCFDGYHLD--TAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKC 1691
Query: 246 KCKQGY 251
C GY
Sbjct: 1692 LCLPGY 1697
Score = 52.8 bits (125), Expect = 8e-07
Identities = 29/68 (42%), Positives = 38/68 (55%), Gaps = 10/68 (14%)
Query: 68 GCKFGECVGPNK---CRCFPGY---TGKTCSQDVNEC---GMKPRPCQH-RCVNTHGSYK 117
GC+ G CV + C CF GY T K DVNEC + C++ +C+NT GSYK
Sbjct: 1631 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1690
Query: 118 CFCLSGHM 125
C CL G++
Sbjct: 1691 CLCLPGYV 1698
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/124 (30%), Positives = 50/124 (40%), Gaps = 32/124 (25%)
Query: 82 CFPGY--TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDAT---CVNSR 136
C PGY T QD+NEC ++ C+NT GSY+C C G PD T CV
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIG--FGPDPTFSSCVPDP 669
Query: 137 TCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL---------DIDECASGKVICPY 187
E+GP C RL +GR C+ + C+ GK P+
Sbjct: 670 PVI---------SEEKGP-C------YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPH 713
Query: 188 NRRC 191
+C
Sbjct: 714 CEKC 717
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/39 (51%), Positives = 24/39 (61%), Gaps = 2/39 (5%)
Query: 168 NGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGF 206
N C DI+EC + +CP N C+NT GSY C C IGF
Sbjct: 620 NNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGF 656
Score = 40.4 bits (93), Expect = 0.004
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 3/46 (6%)
Query: 49 CCYGWRR--NSKGVCEATCEPGCKFGE-CVGPNKCRCFPGYTGKTC 91
CC+GW + S+ + +C P C+ G C+ P C C PG GK C
Sbjct: 173 CCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKAC 218
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 217 CIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAP 273
C DINEC + C + C NT GS++C CK G+ + S +P+ V + P
Sbjct: 624 CQDINECQLQG-VCPN-GECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGP 678
Score = 37.0 bits (84), Expect = 0.047
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 97 ECGMKPRPCQHRCVNTHGSYKCFCLSG-HMLMPDATCVNSRTCAMINCQYS------CED 149
ECG+ RCV Y C C G H+ TCV+ C +N + S C +
Sbjct: 1625 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1684
Query: 150 TEEGPQCLC 158
T+ +CLC
Sbjct: 1685 TDGSYKCLC 1693
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/48 (35%), Positives = 25/48 (52%), Gaps = 4/48 (8%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQH 107
+C C G G+C +KC+C P +TGK C V+ + P+ QH
Sbjct: 402 ICHLPCMNG---GQCSSRDKCQCPPNFTGKLCQIPVHGASV-PKLYQH 445
Score = 30.4 bits (67), Expect = 4.4
Identities = 12/34 (35%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
+INECT++ C +C N + C C +GY+
Sbjct: 874 EINECTVNPDICGA-GHCINLPVRYTCICYEGYR 906
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 114 bits (286), Expect = 2e-25
Identities = 77/231 (33%), Positives = 102/231 (44%), Gaps = 38/231 (16%)
Query: 49 CCYGWRRNSKGVCEATCEPG---------------------CKFGEC---VGPNKCRCFP 84
C G +N++G TC G C G+C G +C C
Sbjct: 764 CVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQ 823
Query: 85 GYT----GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDATCVNSRTC- 138
GY G C +D+NEC CQ C+NT GSY C C G L + TC + C
Sbjct: 824 GYRASGLGDHC-EDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECE 882
Query: 139 --AMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFG 196
+ Q C +TE C+C G ++ +GR C DIDEC + V C + C NT G
Sbjct: 883 HPGLCGPQGECLNTEGSFHCVC-QQGFSISADGRTCEDIDECVNNTV-CDSHGFCDNTAG 940
Query: 197 SYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKC 247
S+ C C+ GF+ C+D+NEC + S C A C N +GSF C C
Sbjct: 941 SFRCLCYQGFQAP--QDGQGCVDVNECELLSGVCG-EAFCENVEGSFLCVC 988
Score = 107 bits (267), Expect = 3e-23
Identities = 72/206 (34%), Positives = 101/206 (49%), Gaps = 19/206 (9%)
Query: 69 CKFGECV---GPNKCR-CFPGY--TGKTCSQDVNECGMKPRPC-QHRCVNTHGSYKCFCL 121
C G CV G +C C GY T + +D++EC + P C +CVN+ GSY+C
Sbjct: 642 CGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDEC-LNPSTCPDEQCVNSPGSYQCVPC 700
Query: 122 SGHMLMPDATCVNSRTCAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECA 179
+ + C++ C N C + E C C G P+ + C DIDEC
Sbjct: 701 TEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSC-HKGYTRTPDHKHCRDIDECQ 759
Query: 180 SGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNT 239
G + N +C NT GS+ C C G++L + + C DI+EC H C+H C NT
Sbjct: 760 QGNLCV--NGQCKNTEGSFRCTCGQGYQLS--AAKDQCEDIDEC-QHRHLCAH-GQCRNT 813
Query: 240 QGSFKCKCKQGYKGNGL--RCSAIPE 263
+GSF+C C QGY+ +GL C I E
Sbjct: 814 EGSFQCVCDQGYRASGLGDHCEDINE 839
Score = 100 bits (248), Expect = 5e-21
Identities = 78/267 (29%), Positives = 105/267 (39%), Gaps = 63/267 (23%)
Query: 52 GWRRNSKGVCEATCEPGCKFGECV---GPNKCRCFPGYTG----KTCSQDVNECGMKPRP 104
GW V E C G+C G C C GYT K C +D++EC
Sbjct: 706 GWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHC-RDIDECQQGNLC 764
Query: 105 CQHRCVNTHGSYKCFCLSGHMLMPDAT-------CVNSRTCAMINCQYSCEDTEEGPQCL 157
+C NT GS++C C G+ L C + CA C +TE QC+
Sbjct: 765 VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCA----HGQCRNTEGSFQCV 820
Query: 158 CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQ-------- 209
C G R + G C DI+EC K +C C+NT GSY C C GF+L
Sbjct: 821 C-DQGYRASGLGDHCEDINECLEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKTCQDI 878
Query: 210 ----------------YISGRYDCI---------------DINECTMDSHTCSHHANCFN 238
G + C+ DI+EC +++ C H C N
Sbjct: 879 NECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDEC-VNNTVCDSHGFCDN 937
Query: 239 TQGSFKCKCKQGYKG--NGLRCSAIPE 263
T GSF+C C QG++ +G C + E
Sbjct: 938 TAGSFRCLCYQGFQAPQDGQGCVDVNE 964
Score = 96.3 bits (238), Expect = 7e-20
Identities = 67/202 (33%), Positives = 98/202 (48%), Gaps = 21/202 (10%)
Query: 62 EATCEPG-CKFGECVG---PNKCRCFPGYTGKTCSQ---DVNECGMKPRPC-QHRCVNTH 113
E T P C G C+ C C+ GY + D++EC C Q RC NT
Sbjct: 551 ECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTE 610
Query: 114 GSYKCFCLSGHMLMPDAT-CVNSRTCAM--INCQYSCEDTEEGPQCLCPSSGLRLAPNGR 170
GS+ C C +G M + T C++ C + + C +T +C SG R+ GR
Sbjct: 611 GSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGR 670
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYC-KCHIGFELQYISGRYDCIDINECTMDSHT 229
C DIDEC + CP + +CVN+ GSY C C GF C+D++EC ++ +
Sbjct: 671 -CEDIDECLNPST-CP-DEQCVNSPGSYQCVPCTEGFR----GWNGQCLDVDEC-LEPNV 722
Query: 230 CSHHANCFNTQGSFKCKCKQGY 251
C+ + +C N +GS+ C C +GY
Sbjct: 723 CA-NGDCSNLEGSYMCSCHKGY 743
Score = 59.7 bits (143), Expect = 7e-09
Identities = 63/256 (24%), Positives = 96/256 (37%), Gaps = 65/256 (25%)
Query: 72 GECV---GPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSG 123
GEC+ G C C G++ G+TC +D++EC H C NT GS++C C G
Sbjct: 891 GECLNTEGSFHCVCQQGFSISADGRTC-EDIDECVNNTVCDSHGFCDNTAGSFRCLCYQG 949
Query: 124 HMLMPDAT-CVNSRTCAMIN--C-QYSCEDTEEGPQCLCPSSGLRLAPNGRDC------- 172
D CV+ C +++ C + CE+ E C+C +P C
Sbjct: 950 FQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTD 1009
Query: 173 --LDIDECASGKVICPYN-----------------RRCVNTFGSYY-------------- 199
+D+D+ K C YN + C T G+ +
Sbjct: 1010 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGT 1069
Query: 200 ------CKCHIGF----ELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQ 249
C GF E +G + D +EC + + C NT+ ++C CKQ
Sbjct: 1070 AEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQ 1129
Query: 250 G--YKGNGLRCSAIPE 263
G Y L+C + E
Sbjct: 1130 GTYYDPVKLQCFDMDE 1145
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/254 (24%), Positives = 85/254 (33%), Gaps = 77/254 (30%)
Query: 56 NSKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQ---DVNECGMKPRPCQHR-CVN 111
+S G C+ T G +C C+ G+ Q DVNEC + C C N
Sbjct: 930 DSHGFCDNTA----------GSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCEN 979
Query: 112 THGSYKCFCLSGHM-LMPDATCVNSRTCAMIN------------CQYSCEDTE------- 151
GS+ C C + P SRT ++ C Y+ D
Sbjct: 980 VEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLA 1039
Query: 152 ---EGPQCLCPSSG-------------------LRLAPNGRDCL---------------D 174
+C C S + P G+ + D
Sbjct: 1040 PNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKD 1099
Query: 175 IDECAS-GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHH 233
DEC G+ IC N C+NT Y C C G Y + C D++EC D +C
Sbjct: 1100 ADECLLFGQEICK-NGFCLNTRPGYECYCKQG--TYYDPVKLQCFDMDEC-QDPSSCID- 1154
Query: 234 ANCFNTQGSFKCKC 247
C NT+GS+ C C
Sbjct: 1155 GQCVNTEGSYNCFC 1168
Score = 54.3 bits (129), Expect = 3e-07
Identities = 26/66 (39%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 188 NRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCS--HHANCFNTQGSFKC 245
N RCV Y C C G+ L + + C+D+NEC ++ S +A C NT GS+KC
Sbjct: 1308 NGRCVRVQEGYTCDCFDGYHLD--TAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKC 1365
Query: 246 KCKQGY 251
C GY
Sbjct: 1366 LCLPGY 1371
Score = 52.8 bits (125), Expect = 8e-07
Identities = 29/68 (42%), Positives = 38/68 (55%), Gaps = 10/68 (14%)
Query: 68 GCKFGECVGPNK---CRCFPGY---TGKTCSQDVNEC---GMKPRPCQH-RCVNTHGSYK 117
GC+ G CV + C CF GY T K DVNEC + C++ +C+NT GSYK
Sbjct: 1305 GCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYK 1364
Query: 118 CFCLSGHM 125
C CL G++
Sbjct: 1365 CLCLPGYV 1372
Score = 43.9 bits (102), Expect = 4e-04
Identities = 38/124 (30%), Positives = 50/124 (40%), Gaps = 32/124 (25%)
Query: 82 CFPGY--TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDAT---CVNSR 136
C PGY T QD+NEC ++ C+NT GSY+C C G PD T CV
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIG--FGPDPTFSSCVPDP 343
Query: 137 TCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCL---------DIDECASGKVICPY 187
E+GP C RL +GR C+ + C+ GK P+
Sbjct: 344 PVI---------SEEKGP-C------YRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPH 387
Query: 188 NRRC 191
+C
Sbjct: 388 CEKC 391
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/39 (51%), Positives = 24/39 (61%), Gaps = 2/39 (5%)
Query: 168 NGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGF 206
N C DI+EC + +CP N C+NT GSY C C IGF
Sbjct: 294 NNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGF 330
Score = 40.4 bits (93), Expect = 0.004
Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 217 CIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAP 273
C DINEC + C + C NT GS++C CK G+ + S +P+ V + P
Sbjct: 298 CQDINECQLQG-VCPN-GECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGP 352
Score = 37.0 bits (84), Expect = 0.047
Identities = 22/69 (31%), Positives = 30/69 (43%), Gaps = 7/69 (10%)
Query: 97 ECGMKPRPCQHRCVNTHGSYKCFCLSG-HMLMPDATCVNSRTCAMINCQYS------CED 149
ECG+ RCV Y C C G H+ TCV+ C +N + S C +
Sbjct: 1299 ECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCIN 1358
Query: 150 TEEGPQCLC 158
T+ +CLC
Sbjct: 1359 TDGSYKCLC 1367
Score = 35.4 bits (80), Expect = 0.14
Identities = 17/48 (35%), Positives = 25/48 (52%), Gaps = 4/48 (8%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQH 107
+C C G G+C +KC+C P +TGK C V+ + P+ QH
Sbjct: 76 ICHLPCMNG---GQCSSRDKCQCPPNFTGKLCQIPVHGASV-PKLYQH 119
Score = 30.4 bits (67), Expect = 4.4
Identities = 12/34 (35%), Positives = 19/34 (55%), Gaps = 1/34 (2%)
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYK 252
+INECT++ C +C N + C C +GY+
Sbjct: 548 EINECTVNPDICGA-GHCINLPVRYTCICYEGYR 580
>gi|19743803 fibulin 5 precursor [Homo sapiens]
Length = 448
Score = 114 bits (284), Expect = 3e-25
Identities = 86/281 (30%), Positives = 122/281 (43%), Gaps = 32/281 (11%)
Query: 7 LALPLLLSWVAGGFGNAASARHHGLLASARQP-GVCHYGT---KLACCYGWRRNSKGVCE 62
L +P G + N S + G +A P +Y T L C +G++ + C
Sbjct: 67 LCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQCV 126
Query: 63 ATCEPGCKFGEC---------VGPNKCRCFPGY---TGKTCSQDVNECGMKPRPCQHRCV 110
E +C G C C GY G+ D++EC + CQ C
Sbjct: 127 DVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCL--DIDEC--RYGYCQQLCA 182
Query: 111 NTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN-CQYSCEDTEEGPQCLCPSSGLRLAPN 168
N GSY C C G L D +C + CA N C +C +T C C G L +
Sbjct: 183 NVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRC-DPGYELEED 241
Query: 169 GRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSH 228
G C D+DEC+ + +C + CVN G+Y+C C G+ L + C DINEC +H
Sbjct: 242 GVHCSDMDECSFSEFLCQHE--CVNQPGTYFCSCPPGYIL--LDDNRSCQDINECEHRNH 297
Query: 229 TCSHHANCFNTQGSFKC----KCKQGY-KGNGLRCSAIPEN 264
TC+ C+N QG FKC +C++ Y + + RC EN
Sbjct: 298 TCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAEN 338
Score = 59.3 bits (142), Expect = 9e-09
Identities = 37/148 (25%), Positives = 52/148 (35%), Gaps = 47/148 (31%)
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYC------ 200
C + Q C ++G L CLDIDEC + C + CVN G Y C
Sbjct: 16 CLPSPGNAQAQC-TNGFDLDRQSGQCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNP 74
Query: 201 -------------------------------------KCHIGFELQYISGRYDCIDINEC 223
C G+++ + C+D++EC
Sbjct: 75 VYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESN---QCVDVDEC 131
Query: 224 TMDSHTCSHHANCFNTQGSFKCKCKQGY 251
DSH C+ C NT+G + C C GY
Sbjct: 132 ATDSHQCNPTQICINTEGGYTCSCTDGY 159
>gi|194328809 latent transforming growth factor beta binding protein
3 isoform 1 [Homo sapiens]
Length = 1303
Score = 110 bits (275), Expect = 3e-24
Identities = 78/214 (36%), Positives = 104/214 (48%), Gaps = 20/214 (9%)
Query: 72 GECV---GPNKCRCFPGYTGKTCS----QDVNECGMKPRPCQH-RCVNTHGSYKCF-CLS 122
G C+ G KC C+PGY K +D++EC P C +C N GS+KC C
Sbjct: 674 GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQP 732
Query: 123 GHMLMPDATCVNSRTCAMIN-CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS 180
G+ C + CA + C CE+ +C C + G AP+GR CLD+DEC +
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSCLDVDECEA 791
Query: 181 GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
G V C N C NT GS+ C+C G+ L R C DI+EC D +C NT
Sbjct: 792 GDV-CD-NGICSNTPGSFQCQCLSGYHLS--RDRSHCEDIDEC--DFPAACIGGDCINTN 845
Query: 241 GSFKCKCKQGYK-GNGLRCSAIPENSVKEVLRAP 273
GS++C C QG++ G +C I E S L P
Sbjct: 846 GSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLP 879
Score = 104 bits (259), Expect = 2e-22
Identities = 83/226 (36%), Positives = 105/226 (46%), Gaps = 25/226 (11%)
Query: 42 HYGTKLACCYGWRRNSKG--VCEATCE----PGCKFGECV---GPNKC-RCFPGYT--GK 89
HY K C G+R + VCE E C G+C G KC C PGY G
Sbjct: 682 HY--KCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGG 739
Query: 90 TCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN-CQYS 146
+DVNEC + PC C N GS++C C G+ PD +C++ C + C
Sbjct: 740 GACRDVNECA-EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG 798
Query: 147 -CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIG 205
C +T QC C SG L+ + C DIDEC C C+NT GSY C C G
Sbjct: 799 ICSNTPGSFQCQC-LSGYHLSRDRSHCEDIDEC-DFPAAC-IGGDCINTNGSYRCLCPQG 855
Query: 206 FELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
L + GR C DI+EC+ D C H C N QGS+ C C +G+
Sbjct: 856 HRL--VGGR-KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 88.6 bits (218), Expect = 1e-17
Identities = 76/217 (35%), Positives = 96/217 (44%), Gaps = 23/217 (10%)
Query: 69 CKFGECV-GPN--KCRCFPGYTGKTCSQ---DVNECGMKP-RPCQHRCVNTHGSYKCFCL 121
C GECV GP C C PGY + DVNEC +P P + C+NT GSY C C
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCN 644
Query: 122 SGHMLMPDA---TCVNSRTCA---MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
G+ L A +CV+ CA + C + +C C A C DI
Sbjct: 645 RGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDI 704
Query: 176 DECASGKVICPYNRRCVNTFGSYYC-KCHIGFELQYISGRYDCIDINECTMDSHTCSHHA 234
DEC CP + +C N GS+ C C G+ Q G C D+NEC + CS
Sbjct: 705 DECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQ---GGGACRDVNECA-EGSPCS-PG 757
Query: 235 NCFNTQGSFKCKCKQGY--KGNGLRCSAIPENSVKEV 269
C N GSF+C C QGY +G C + E +V
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDV 794
Score = 75.5 bits (184), Expect = 1e-13
Identities = 43/123 (34%), Positives = 60/123 (48%), Gaps = 6/123 (4%)
Query: 156 CLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRY 215
C C + G R P R C+D++EC + + P C+NT GSY C C+ G+ L +G
Sbjct: 599 CHC-NPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
Query: 216 DCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGT 275
C+D+NEC H C C N G +KC C GY+ L+ S P + R P +
Sbjct: 657 SCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYR---LKASRPPVCEDIDECRDPSS 712
Query: 276 IKD 278
D
Sbjct: 713 CPD 715
Score = 69.3 bits (168), Expect = 9e-12
Identities = 66/248 (26%), Positives = 93/248 (37%), Gaps = 60/248 (24%)
Query: 54 RRNSKGVCEATCEPGCKFGECVGPN---KCRCFPGYT---GKTCSQDVNECGMKPRPC-- 105
R + + + E C G+C+ N +C C G+ G+ C QD++EC P C
Sbjct: 821 RSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLP 879
Query: 106 QHRCVNTHGSYKCFCLSG----------------------HMLMPDATCVNSRTCAMINC 143
C N GSY C C G ++ D +S +
Sbjct: 880 HGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQ 939
Query: 144 QYSCEDTEEG--PQCL---CP----SSGLRLAPNGRDCL--------------DIDECAS 180
Q C G C CP + L P+G+ DIDEC
Sbjct: 940 QECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999
Query: 181 -GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNT 239
G IC + CVNT Y C C GF Y +C+D++EC +D C + C NT
Sbjct: 1000 FGSEICKEGK-CVNTQPGYECYCKQGF--YYDGNLLECVDVDEC-LDESNC-RNGVCENT 1054
Query: 240 QGSFKCKC 247
+G ++C C
Sbjct: 1055 RGGYRCAC 1062
Score = 68.6 bits (166), Expect = 1e-11
Identities = 64/287 (22%), Positives = 98/287 (34%), Gaps = 73/287 (25%)
Query: 49 CCYGWRRNSKGVCEATCEPG---------------------CKFGECV---GPNKCRCFP 84
C GW N G TC G C G C G +C+C
Sbjct: 754 CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
Query: 85 GY---TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCA-- 139
GY ++ +D++EC C+NT+GSY+C C GH L+ C + C+
Sbjct: 814 GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQD 873
Query: 140 --MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE----------------CASG 181
+ +C++ + C+C G + C ++++ C S
Sbjct: 874 PSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
Query: 182 KVICPYNRRCVNTFGS--------YYCKCHIGFELQYIS---------------GRYDCI 218
+ C + G+ Y C + E + G
Sbjct: 933 LATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR 992
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQG--YKGNGLRCSAIPE 263
DI+EC + C NTQ ++C CKQG Y GN L C + E
Sbjct: 993 DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039
Score = 60.1 bits (144), Expect = 5e-09
Identities = 70/270 (25%), Positives = 93/270 (34%), Gaps = 72/270 (26%)
Query: 60 VCEATCEPGCKFGECV---GPNKCRCFP----GYTGKTC----SQDVNECGMKPRPCQH- 107
V E E C+ G C G +C C P + C DV+EC P C+
Sbjct: 1037 VDECLDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDEC-QDPAACRPG 1095
Query: 108 RCVNTHGSYKCFC-------------------------------------------LSGH 124
RCVN GSY+C C L+G
Sbjct: 1096 RCVNLPGSYRCECRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGP 1155
Query: 125 MLMPDATCVNS--------RTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDID 176
L D C R C C ++ +S L L RD D
Sbjct: 1156 ALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD-EDSS 1214
Query: 177 ECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC---TMDSHTCSHH 233
E S + C + RCV G C+C GF+L + R C+DI+EC C
Sbjct: 1215 EEDSDECRC-VSGRCVPRPGGAVCECPGGFQLD--ASRARCVDIDECRELNQRGLLCKSE 1271
Query: 234 ANCFNTQGSFKCKCKQGYKGNGLRCSAIPE 263
C NT GSF+C CK G+ + + +P+
Sbjct: 1272 -RCVNTSGSFRCVCKAGFARSRPHGACVPQ 1300
Score = 58.2 bits (139), Expect = 2e-08
Identities = 42/125 (33%), Positives = 59/125 (47%), Gaps = 13/125 (10%)
Query: 88 GKTCSQDVNECGM-KPRPCQH-RCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCA-MINC 143
G +D++EC + C+ +CVNT Y+C+C G + CV+ C NC
Sbjct: 987 GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
Query: 144 QYS-CEDTEEGPQCLCPSSGLRLAPNGRDCL-----DIDECASGKVICPYNRRCVNTFGS 197
+ CE+T G +C C + +P R CL D+DEC P RCVN GS
Sbjct: 1047 RNGVCENTRGGYRCAC-TPPAEYSPAQRQCLSPEEMDVDECQDPAACRP--GRCVNLPGS 1103
Query: 198 YYCKC 202
Y C+C
Sbjct: 1104 YRCEC 1108
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/134 (34%), Positives = 61/134 (45%), Gaps = 19/134 (14%)
Query: 66 EPGCKFGECVGPNKCRCFPGYT--GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLS 122
+PG GE VG + C GY T QD+NEC M P C+H C+N GSY+C C
Sbjct: 329 KPGPVRGE-VGAD---CPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPP 383
Query: 123 GHMLMPDAT-CV------NSRTCAMINCQYSCE---DTEEGPQCLCPSSGLRLAPNGRDC 172
GH L P T C+ S +++ ++ C+ T Q C S G + C
Sbjct: 384 GHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443
Query: 173 LDIDECASGKVICP 186
D A+ K ICP
Sbjct: 444 -PTDGTAAFKEICP 456
Score = 38.1 bits (87), Expect = 0.021
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 217 CIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVL 270
C DINEC M H +C N GS++C C G+ R I + ++ L
Sbjct: 353 CQDINECAMPG--VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSL 404
Score = 37.4 bits (85), Expect = 0.036
Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 17/113 (15%)
Query: 158 CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDC 217
CP RL N C DI+ECA V C + C+N GSY C C G L R C
Sbjct: 341 CPQGYKRL--NSTHCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLG--PSRTQC 394
Query: 218 I-----DINEC---TMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIP 262
I + + C H C H T+ C C G K G RC P
Sbjct: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQ--LCCCSVG-KAWGARCQRCP 444
Score = 31.2 bits (69), Expect = 2.6
Identities = 14/40 (35%), Positives = 18/40 (45%), Gaps = 3/40 (7%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECG 99
VC C G G+C N+C C P +TG+ C G
Sbjct: 112 VCPLPCMNG---GQCSSRNQCLCPPDFTGRFCQVPAGGAG 148
>gi|18497288 latent transforming growth factor beta binding protein
3 isoform 2 [Homo sapiens]
Length = 1256
Score = 110 bits (275), Expect = 3e-24
Identities = 78/214 (36%), Positives = 104/214 (48%), Gaps = 20/214 (9%)
Query: 72 GECV---GPNKCRCFPGYTGKTCS----QDVNECGMKPRPCQH-RCVNTHGSYKCF-CLS 122
G C+ G KC C+PGY K +D++EC P C +C N GS+KC C
Sbjct: 674 GFCINFPGHYKCNCYPGYRLKASRPPVCEDIDEC-RDPSSCPDGKCENKPGSFKCIACQP 732
Query: 123 GHMLMPDATCVNSRTCAMIN-CQYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECAS 180
G+ C + CA + C CE+ +C C + G AP+GR CLD+DEC +
Sbjct: 733 GYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTC-AQGYAPAPDGRSCLDVDECEA 791
Query: 181 GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQ 240
G V C N C NT GS+ C+C G+ L R C DI+EC D +C NT
Sbjct: 792 GDV-CD-NGICSNTPGSFQCQCLSGYHLS--RDRSHCEDIDEC--DFPAACIGGDCINTN 845
Query: 241 GSFKCKCKQGYK-GNGLRCSAIPENSVKEVLRAP 273
GS++C C QG++ G +C I E S L P
Sbjct: 846 GSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLP 879
Score = 104 bits (259), Expect = 2e-22
Identities = 83/226 (36%), Positives = 105/226 (46%), Gaps = 25/226 (11%)
Query: 42 HYGTKLACCYGWRRNSKG--VCEATCE----PGCKFGECV---GPNKC-RCFPGYT--GK 89
HY K C G+R + VCE E C G+C G KC C PGY G
Sbjct: 682 HY--KCNCYPGYRLKASRPPVCEDIDECRDPSSCPDGKCENKPGSFKCIACQPGYRSQGG 739
Query: 90 TCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN-CQYS 146
+DVNEC + PC C N GS++C C G+ PD +C++ C + C
Sbjct: 740 GACRDVNECA-EGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNG 798
Query: 147 -CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIG 205
C +T QC C SG L+ + C DIDEC C C+NT GSY C C G
Sbjct: 799 ICSNTPGSFQCQC-LSGYHLSRDRSHCEDIDEC-DFPAAC-IGGDCINTNGSYRCLCPQG 855
Query: 206 FELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
L + GR C DI+EC+ D C H C N QGS+ C C +G+
Sbjct: 856 HRL--VGGR-KCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGF 898
Score = 88.6 bits (218), Expect = 1e-17
Identities = 76/217 (35%), Positives = 96/217 (44%), Gaps = 23/217 (10%)
Query: 69 CKFGECV-GPN--KCRCFPGYTGKTCSQ---DVNECGMKP-RPCQHRCVNTHGSYKCFCL 121
C GECV GP C C PGY + DVNEC +P P + C+NT GSY C C
Sbjct: 585 CGHGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCN 644
Query: 122 SGHMLMPDA---TCVNSRTCA---MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDI 175
G+ L A +CV+ CA + C + +C C A C DI
Sbjct: 645 RGYRLHVGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDI 704
Query: 176 DECASGKVICPYNRRCVNTFGSYYC-KCHIGFELQYISGRYDCIDINECTMDSHTCSHHA 234
DEC CP + +C N GS+ C C G+ Q G C D+NEC + CS
Sbjct: 705 DECRDPS-SCP-DGKCENKPGSFKCIACQPGYRSQ---GGGACRDVNECA-EGSPCS-PG 757
Query: 235 NCFNTQGSFKCKCKQGY--KGNGLRCSAIPENSVKEV 269
C N GSF+C C QGY +G C + E +V
Sbjct: 758 WCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDV 794
Score = 75.5 bits (184), Expect = 1e-13
Identities = 43/123 (34%), Positives = 60/123 (48%), Gaps = 6/123 (4%)
Query: 156 CLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRY 215
C C + G R P R C+D++EC + + P C+NT GSY C C+ G+ L +G
Sbjct: 599 CHC-NPGYRSHPQHRYCVDVNECEA-EPCGPGRGICMNTGGSYNCHCNRGYRLHVGAGGR 656
Query: 216 DCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVLRAPGT 275
C+D+NEC H C C N G +KC C GY+ L+ S P + R P +
Sbjct: 657 SCVDLNECA-KPHLCGDGGFCINFPGHYKCNCYPGYR---LKASRPPVCEDIDECRDPSS 712
Query: 276 IKD 278
D
Sbjct: 713 CPD 715
Score = 69.3 bits (168), Expect = 9e-12
Identities = 66/248 (26%), Positives = 93/248 (37%), Gaps = 60/248 (24%)
Query: 54 RRNSKGVCEATCEPGCKFGECVGPN---KCRCFPGYT---GKTCSQDVNECGMKPRPC-- 105
R + + + E C G+C+ N +C C G+ G+ C QD++EC P C
Sbjct: 821 RSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKC-QDIDECSQDPSLCLP 879
Query: 106 QHRCVNTHGSYKCFCLSG----------------------HMLMPDATCVNSRTCAMINC 143
C N GSY C C G ++ D +S +
Sbjct: 880 HGACKNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQ 939
Query: 144 QYSCEDTEEG--PQCL---CP----SSGLRLAPNGRDCL--------------DIDECAS 180
Q C G C CP + L P+G+ DIDEC
Sbjct: 940 QECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECML 999
Query: 181 -GKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNT 239
G IC + CVNT Y C C GF Y +C+D++EC +D C + C NT
Sbjct: 1000 FGSEICKEGK-CVNTQPGYECYCKQGF--YYDGNLLECVDVDEC-LDESNC-RNGVCENT 1054
Query: 240 QGSFKCKC 247
+G ++C C
Sbjct: 1055 RGGYRCAC 1062
Score = 68.6 bits (166), Expect = 1e-11
Identities = 64/287 (22%), Positives = 98/287 (34%), Gaps = 73/287 (25%)
Query: 49 CCYGWRRNSKGVCEATCEPG---------------------CKFGECV---GPNKCRCFP 84
C GW N G TC G C G C G +C+C
Sbjct: 754 CSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLS 813
Query: 85 GY---TGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDATCVNSRTCA-- 139
GY ++ +D++EC C+NT+GSY+C C GH L+ C + C+
Sbjct: 814 GYHLSRDRSHCEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQD 873
Query: 140 --MINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE----------------CASG 181
+ +C++ + C+C G + C ++++ C S
Sbjct: 874 PSLCLPHGACKNLQGSYVCVC-DEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSV 932
Query: 182 KVICPYNRRCVNTFGS--------YYCKCHIGFELQYIS---------------GRYDCI 218
+ C + G+ Y C + E + G
Sbjct: 933 LATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHR 992
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQG--YKGNGLRCSAIPE 263
DI+EC + C NTQ ++C CKQG Y GN L C + E
Sbjct: 993 DIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDE 1039
Score = 58.2 bits (139), Expect = 2e-08
Identities = 65/254 (25%), Positives = 87/254 (34%), Gaps = 64/254 (25%)
Query: 69 CKFGECVGPN---KCRCFPG--YTGKTCS-QDVNECGMKPRPCQHRCVNTHGSYKCFC-- 120
CK G+CV +C C G Y G DV+EC + C NT G Y+C C
Sbjct: 1005 CKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCRNGVCENTRGGYRCACTP 1064
Query: 121 ----------------------------------------LSGHMLMPDATCVNS----- 135
L+G L D C
Sbjct: 1065 PAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWG 1124
Query: 136 ---RTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCV 192
R C C ++ +S L L RD D E S + C + RCV
Sbjct: 1125 AQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRD-EDSSEEDSDECRC-VSGRCV 1182
Query: 193 NTFGSYYCKCHIGFELQYISGRYDCIDINEC---TMDSHTCSHHANCFNTQGSFKCKCKQ 249
G C+C GF+L + R C+DI+EC C C NT GSF+C CK
Sbjct: 1183 PRPGGAVCECPGGFQLD--ASRARCVDIDECRELNQRGLLCKSE-RCVNTSGSFRCVCKA 1239
Query: 250 GYKGNGLRCSAIPE 263
G+ + + +P+
Sbjct: 1240 GFARSRPHGACVPQ 1253
Score = 51.6 bits (122), Expect = 2e-06
Identities = 46/134 (34%), Positives = 61/134 (45%), Gaps = 19/134 (14%)
Query: 66 EPGCKFGECVGPNKCRCFPGYT--GKTCSQDVNECGMKPRPCQHR-CVNTHGSYKCFCLS 122
+PG GE VG + C GY T QD+NEC M P C+H C+N GSY+C C
Sbjct: 329 KPGPVRGE-VGAD---CPQGYKRLNSTHCQDINECAM-PGVCRHGDCLNNPGSYRCVCPP 383
Query: 123 GHMLMPDAT-CV------NSRTCAMINCQYSCE---DTEEGPQCLCPSSGLRLAPNGRDC 172
GH L P T C+ S +++ ++ C+ T Q C S G + C
Sbjct: 384 GHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRC 443
Query: 173 LDIDECASGKVICP 186
D A+ K ICP
Sbjct: 444 -PTDGTAAFKEICP 456
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/95 (30%), Positives = 45/95 (47%), Gaps = 6/95 (6%)
Query: 88 GKTCSQDVNECGM-KPRPCQH-RCVNTHGSYKCFCLSGHMLMPD-ATCVNSRTCA-MINC 143
G +D++EC + C+ +CVNT Y+C+C G + CV+ C NC
Sbjct: 987 GIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNC 1046
Query: 144 QYS-CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDE 177
+ CE+T G +C C + +P R CL +E
Sbjct: 1047 RNGVCENTRGGYRCAC-TPPAEYSPAQRQCLSPEE 1080
Score = 38.1 bits (87), Expect = 0.021
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 217 CIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKEVL 270
C DINEC M H +C N GS++C C G+ R I + ++ L
Sbjct: 353 CQDINECAMPG--VCRHGDCLNNPGSYRCVCPPGHSLGPSRTQCIADKPEEKSL 404
Score = 37.4 bits (85), Expect = 0.036
Identities = 38/113 (33%), Positives = 44/113 (38%), Gaps = 17/113 (15%)
Query: 158 CPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDC 217
CP RL N C DI+ECA V C + C+N GSY C C G L R C
Sbjct: 341 CPQGYKRL--NSTHCQDINECAMPGV-CRHGD-CLNNPGSYRCVCPPGHSLG--PSRTQC 394
Query: 218 I-----DINEC---TMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIP 262
I + + C H C H T+ C C G K G RC P
Sbjct: 395 IADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQ--LCCCSVG-KAWGARCQRCP 444
Score = 31.2 bits (69), Expect = 2.6
Identities = 14/40 (35%), Positives = 18/40 (45%), Gaps = 3/40 (7%)
Query: 60 VCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECG 99
VC C G G+C N+C C P +TG+ C G
Sbjct: 112 VCPLPCMNG---GQCSSRNQCLCPPDFTGRFCQVPAGGAG 148
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 110 bits (275), Expect = 3e-24
Identities = 75/231 (32%), Positives = 99/231 (42%), Gaps = 38/231 (16%)
Query: 65 CEPGCKFGECVGPNKCRCFPGYTGKTCSQ------------DVNECGMKPRPCQHR-CVN 111
C P G KC C G++ T + D+NEC +H CVN
Sbjct: 91 CGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVN 150
Query: 112 THGSYKCFCLSGHMLMPDATCVNSRTCAMINC---QYSCEDTEEGPQCLC----PSSGLR 164
+ GSY C C G + ++TC + CA +C +T C C SS
Sbjct: 151 SMGSYSCSCQVG-FISRNSTCEDVDECADPRACPEHATCNNTVGNYSCFCNPGFESSSGH 209
Query: 165 LAPNG--RDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGF-----ELQYISGRYDC 217
L+ G C DIDEC +CP N C NT GSY+C CH GF +L + +C
Sbjct: 210 LSFQGLKASCEDIDECTE---MCPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVEC 266
Query: 218 IDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVKE 268
DI+EC D TC ++ C N GS+ C C G+ N PE S K+
Sbjct: 267 RDIDECRQDPSTCGPNSICTNALGSYSCGCIAGFHPN-------PEGSQKD 310
Score = 89.0 bits (219), Expect = 1e-17
Identities = 60/193 (31%), Positives = 79/193 (40%), Gaps = 36/193 (18%)
Query: 84 PGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSYKCFCLSG--------HMLMPDATCVNS 135
P G C +D C P C NT SY C C G H P C +
Sbjct: 28 PNTKGNNC-RDSTLC-----PAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDI 81
Query: 136 RTCAM----INCQYSCEDTEEGPQCLCPSSGLRLAPNGRD----------CLDIDECASG 181
C+ SC++ +C C +P G D C DI+EC +
Sbjct: 82 DECSQSPQPCGPNSSCKNLSGRYKCSCLDG--FSSPTGNDWVPGKPGNFSCTDINECLTS 139
Query: 182 KVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQG 241
V CP + CVN+ GSY C C +GF IS C D++EC D C HA C NT G
Sbjct: 140 SV-CPEHSDCVNSMGSYSCSCQVGF----ISRNSTCEDVDECA-DPRACPEHATCNNTVG 193
Query: 242 SFKCKCKQGYKGN 254
++ C C G++ +
Sbjct: 194 NYSCFCNPGFESS 206
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 110 bits (274), Expect = 4e-24
Identities = 74/228 (32%), Positives = 101/228 (44%), Gaps = 23/228 (10%)
Query: 28 HHGLLASARQPGVCHYGTKLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYT 87
H G S Q H + C +C T + G C C PG+
Sbjct: 144 HSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHICRETPKGGVA---------CDCRPGFD 194
Query: 88 GKTCSQDVN-ECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN--C 143
+D C CQH C +T C C + L D TC+ TCA+ N C
Sbjct: 195 LAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE--TCAVNNGGC 252
Query: 144 QYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCH 203
+C+DT G +C CP G L P+G+ C DI+EC C + C NT GS+ C C
Sbjct: 253 DRTCKDTATGVRCSCPV-GFTLQPDGKTCKDINECLVNNGGCDHF--CRNTVGSFECGCR 309
Query: 204 IGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGY 251
G++L ++ C DI+EC+ + TC H C N+ GSF+C C +GY
Sbjct: 310 KGYKL--LTDERTCQDIDECSFE-RTCDHI--CINSPGSFQCLCHRGY 352
Score = 107 bits (267), Expect = 3e-23
Identities = 86/267 (32%), Positives = 109/267 (40%), Gaps = 71/267 (26%)
Query: 46 KLACCYGWRRNSKGVCEAT--CEPGCKFGECV-------GPNKCRCFPGYT----GKTCS 92
K C G++ K CE CE G CV G +C CF G+ G C
Sbjct: 58 KCLCKPGYKGEGKQ-CEDIDECENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCL 116
Query: 93 QDVNECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCV------------------ 133
DV+EC CQ CVN GSY+C C SG L + TC+
Sbjct: 117 -DVDECQDNNGGCQQICVNAMGSYECQCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAH 175
Query: 134 ----------------------NSRTCAMI------NCQYSCEDTEEGPQCLCPSSGLRL 165
N + C + CQ+SCEDT+ GP C C L
Sbjct: 176 ICRETPKGGVACDCRPGFDLAQNQKDCTLTCNYGNGGCQHSCEDTDTGPTCGCHQK-YAL 234
Query: 166 APNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTM 225
+GR C I+ CA C +R C +T C C +GF LQ C DINEC +
Sbjct: 235 HSDGRTC--IETCAVNNGGC--DRTCKDTATGVRCSCPVGFTLQ--PDGKTCKDINECLV 288
Query: 226 DSHTCSHHANCFNTQGSFKCKCKQGYK 252
++ C H C NT GSF+C C++GYK
Sbjct: 289 NNGGCDHF--CRNTVGSFECGCRKGYK 313
Score = 105 bits (261), Expect = 1e-22
Identities = 71/221 (32%), Positives = 101/221 (45%), Gaps = 32/221 (14%)
Query: 47 LACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKP 102
L C YG G C+ +CE GP C C Y G+TC + C +
Sbjct: 204 LTCNYG-----NGGCQHSCED-----TDTGPT-CGCHQKYALHSDGRTC---IETCAVNN 249
Query: 103 RPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLCP 159
C C +T +C C G L PD TC + C + N C + C +T +C C
Sbjct: 250 GGCDRTCKDTATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGC- 308
Query: 160 SSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCID 219
G +L + R C DIDEC+ + + C+N+ GS+ C CH G+ L G C D
Sbjct: 309 RKGYKLLTDERTCQDIDECSFERTC---DHICINSPGSFQCLCHRGYILY---GTTHCGD 362
Query: 220 INECTMDSHTCSHHANCFNTQGSFKCKCKQGYK--GNGLRC 258
++EC+M + +C C NT+GS++C C G + NG C
Sbjct: 363 VDECSMSNGSCDQ--GCVNTKGSYECVCPPGRRLHWNGKDC 401
Score = 92.0 bits (227), Expect = 1e-18
Identities = 62/196 (31%), Positives = 93/196 (47%), Gaps = 20/196 (10%)
Query: 57 SKGVCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMKPRPCQHRCVNT 112
+ G C+ TC+ + +C C G+T GKTC +D+NEC + C H C NT
Sbjct: 248 NNGGCDRTCK------DTATGVRCSCPVGFTLQPDGKTC-KDINECLVNNGGCDHFCRNT 300
Query: 113 HGSYKCFCLSGHMLMPD-ATCVNSRTCAM-INCQYSCEDTEEGPQCLCPSSGLRLAPNGR 170
GS++C C G+ L+ D TC + C+ C + C ++ QCLC +
Sbjct: 301 VGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYILYGTT-- 358
Query: 171 DCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTC 230
C D+DEC+ C ++ CVNT GSY C C G L + +G+ DC++ +C + T
Sbjct: 359 HCGDVDECSMSNGSC--DQGCVNTKGSYECVCPPGRRLHW-NGK-DCVETGKCLSRAKTS 414
Query: 231 SH-HANCFNTQGSFKC 245
+C G C
Sbjct: 415 PRAQLSCSKAGGVESC 430
Score = 80.9 bits (198), Expect = 3e-15
Identities = 58/178 (32%), Positives = 77/178 (43%), Gaps = 19/178 (10%)
Query: 85 GYTGKTCSQDVNECGMKPRPCQHR--CVNTHGSYKCFCLSGHMLMPDATCVNSRTCAMI- 141
G +G S DV+EC C C NT SYKC C G+ C + C
Sbjct: 24 GGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYK-GEGKQCEDIDECENDY 82
Query: 142 ---NCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSY 198
C + C + +C C G LA +G +CLD+DEC C + CVN GSY
Sbjct: 83 YNGGCVHECINIPGNYRCTC-FDGFMLAHDGHNCLDVDECQDNNGGC--QQICVNAMGSY 139
Query: 199 YCKCHIGFELQYISGRYDCIDIN----ECTMDSHTCSHHANCFNT-QGSFKCKCKQGY 251
C+CH GF L ++ CI + C H C+H C T +G C C+ G+
Sbjct: 140 ECQCHSGFFLS--DNQHTCIHRSNEGMNCMNKDHGCAH--ICRETPKGGVACDCRPGF 193
Score = 52.4 bits (124), Expect = 1e-06
Identities = 27/74 (36%), Positives = 36/74 (48%), Gaps = 8/74 (10%)
Query: 212 SGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPE-------- 263
SG +D++EC+ + C A C NT S+KC CK GYKG G +C I E
Sbjct: 26 SGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGYKGEGKQCEDIDECENDYYNG 85
Query: 264 NSVKEVLRAPGTIK 277
V E + PG +
Sbjct: 86 GCVHECINIPGNYR 99
Score = 51.6 bits (122), Expect = 2e-06
Identities = 38/112 (33%), Positives = 44/112 (39%), Gaps = 12/112 (10%)
Query: 62 EATCEPGCKFGECVGPNKCRCFPGYT--GKTCSQDVNECGMKPRPCQHRCVNTHGSYKCF 119
E TC+ C G +C C GY G T DV+EC M C CVNT GSY+C
Sbjct: 330 ERTCDHICI--NSPGSFQCLCHRGYILYGTTHCGDVDECSMSNGSCDQGCVNTKGSYECV 387
Query: 120 CLSGHML-MPDATCVNSRTC-----AMINCQYSCEDTEEGPQCL--CPSSGL 163
C G L CV + C Q SC C CP+ L
Sbjct: 388 CPPGRRLHWNGKDCVETGKCLSRAKTSPRAQLSCSKAGGVESCFLSCPAHTL 439
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 109 bits (273), Expect = 6e-24
Identities = 75/238 (31%), Positives = 100/238 (42%), Gaps = 47/238 (19%)
Query: 65 CEPGCKFGE---CVGPNK---CRCFPGYTG----KTCSQDVNECGMKPRPCQHR--CVNT 112
C G K GE C N C C GY +D++EC K C CVN
Sbjct: 395 CAEGPKCGENSECKNWNTKATCECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNL 454
Query: 113 HGSYKCFCLSGHMLMPDATCVNSRTCA--MINCQYS--CEDTEEGPQCLCPSS------- 161
G Y+C C+ G++ + D +C C NC + C +T +G C C
Sbjct: 455 PGLYRCDCVPGYIRVDDFSCTEHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTI 514
Query: 162 ------------GLRLAPN---------GRDC-LDIDECASGKVICPYNRRCVNTFGSYY 199
G +APN G C DIDEC+ G + C + RCVN G Y+
Sbjct: 515 CRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYH 574
Query: 200 CKCHIGF--ELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNG 255
C+C GF + Y CIDI+EC + +HTC + + C N G F C C G +G
Sbjct: 575 CECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSG 632
Score = 81.6 bits (200), Expect = 2e-15
Identities = 58/185 (31%), Positives = 78/185 (42%), Gaps = 29/185 (15%)
Query: 44 GTKLACCYGWRRNSKGVCEATCEPGCKF-GECVGPNKCRCFPGYTGKTCSQDVNECGMKP 102
G C G+ N +C A CE GC++ G CV PNKC C G+TG C +D++EC
Sbjct: 499 GHSCTCKPGYVGNGT-ICRAFCEEGCRYGGTCVAPNKCVCPSGFTGSHCEKDIDECSEGI 557
Query: 103 RPCQH--RCVNTHGSYKCFCLSGH-----MLMPDATCVNSRTCAM--INC--QYSCEDTE 151
C + RCVN G Y C C SG + +C++ CA+ C +C +
Sbjct: 558 IECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTCWNDSACINLA 617
Query: 152 EGPQCLCPSSGL---------RLAPNGR------DCLDIDECASGKVICPYNR-RCVNTF 195
G CLCPS L NG+ D + C GK+ C C N
Sbjct: 618 GGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCSVCSCKDGKIFCRRTACDCQNPS 677
Query: 196 GSYYC 200
+C
Sbjct: 678 ADLFC 682
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/218 (27%), Positives = 79/218 (36%), Gaps = 27/218 (12%)
Query: 59 GVCEATCEPGCKFG-------ECVGPNKCR-CFPGYTGKTCSQDVNECGMKPRPCQHRCV 110
G C C P C +G + + CR C G K P C +
Sbjct: 325 GQCCKVCRPKCIYGGKVLAEGQRILTKSCRECRGGVLVKITEM------CPPLNCSEKDH 378
Query: 111 NTHGSYKCFCLSGHMLMPDAT-CVNSRTCAMINCQYSCEDTEEGPQCLCPSSGLRLAPNG 169
+ C GH + C + C N + +CE C S + + +
Sbjct: 379 ILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKATCE---------CKSGYISVQGDS 429
Query: 170 RDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHT 229
C DIDECA+ C N CVN G Y C C G+ + C + +EC H
Sbjct: 430 AYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGY---IRVDDFSCTEHDECGSGQHN 486
Query: 230 CSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPENSVK 267
C +A C NT C CK GY GNG C A E +
Sbjct: 487 CDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCR 524
>gi|31377568 signal peptide, CUB domain, EGF-like 3 [Homo sapiens]
Length = 993
Score = 109 bits (273), Expect = 6e-24
Identities = 70/192 (36%), Positives = 92/192 (47%), Gaps = 15/192 (7%)
Query: 80 CRCFPGYTGKTCSQDVN-ECGMKPRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRT 137
C C PG+ +D C CQH C +T +C C +L D TC+ T
Sbjct: 182 CECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFVLHTDGKTCIE--T 239
Query: 138 CAMIN--CQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTF 195
CA+ N C C D G C CP G L P+ + C DIDEC C + C NT
Sbjct: 240 CAVNNGGCDSKCHDAATGVHCTCPV-GFMLQPDRKTCKDIDECRLNNGGCDHI--CRNTV 296
Query: 196 GSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNG 255
GS+ C C G++L + +C DI+EC+ D TC H C NT GSF+C C +GY G
Sbjct: 297 GSFECSCKKGYKL--LINERNCQDIDECSFD-RTCDHI--CVNTPGSFQCLCHRGYLLYG 351
Query: 256 L-RCSAIPENSV 266
+ C + E S+
Sbjct: 352 ITHCGDVDECSI 363
Score = 107 bits (267), Expect = 3e-23
Identities = 82/261 (31%), Positives = 111/261 (42%), Gaps = 67/261 (25%)
Query: 61 CEATCEPGCKFGECV---GPNKCRCFPGY----TGKTCSQDVNECGMKPRPCQHRCVNTH 113
CE GC +CV G +C C+ G+ G C DV+EC CQ CVN
Sbjct: 74 CEREDNAGCVH-DCVNIPGNYRCTCYDGFHLAHDGHNCL-DVDECAEGNGGCQQSCVNMM 131
Query: 114 GSYKCFCLSGHMLMPDA-TCV--------------------------------------- 133
GSY+C C G L + TC+
Sbjct: 132 GSYECHCREGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELT 191
Query: 134 -NSRTCAMI------NCQYSCEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICP 186
N R C + CQ++C+DTE+GP+C C + L +G+ C I+ CA C
Sbjct: 192 KNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHIKFV-LHTDGKTC--IETCAVNNGGC- 247
Query: 187 YNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINECTMDSHTCSHHANCFNTQGSFKCK 246
+ +C + +C C +GF LQ R C DI+EC +++ C H C NT GSF+C
Sbjct: 248 -DSKCHDAATGVHCTCPVGFMLQ--PDRKTCKDIDECRLNNGGCDHI--CRNTVGSFECS 302
Query: 247 CKQGYK--GNGLRCSAIPENS 265
CK+GYK N C I E S
Sbjct: 303 CKKGYKLLINERNCQDIDECS 323
Score = 105 bits (263), Expect = 8e-23
Identities = 71/212 (33%), Positives = 100/212 (47%), Gaps = 30/212 (14%)
Query: 46 KLACCYGWRRNSKGVCEATCEPGCKFGECVGPNKCRCFPGYT----GKTCSQDVNECGMK 101
KL C YG G C+ TC+ + GP +C C + GKTC + C +
Sbjct: 198 KLTCNYG-----NGGCQHTCDDTEQ-----GP-RCGCHIKFVLHTDGKTC---IETCAVN 243
Query: 102 PRPCQHRCVNTHGSYKCFCLSGHMLMPDA-TCVNSRTCAMIN--CQYSCEDTEEGPQCLC 158
C +C + C C G ML PD TC + C + N C + C +T +C C
Sbjct: 244 NGGCDSKCHDAATGVHCTCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSC 303
Query: 159 PSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCI 218
G +L N R+C DIDEC+ + + CVNT GS+ C CH G+ L I+ C
Sbjct: 304 -KKGYKLLINERNCQDIDECSFDRTC---DHICVNTPGSFQCLCHRGYLLYGIT---HCG 356
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQG 250
D++EC+++ C C NT GS++C C G
Sbjct: 357 DVDECSINRGGCRF--GCINTPGSYQCTCPAG 386
Score = 86.7 bits (213), Expect = 5e-17
Identities = 59/171 (34%), Positives = 79/171 (46%), Gaps = 18/171 (10%)
Query: 92 SQDVNECGMKPRPCQHR--CVNTHGSYKCFCLSGHMLMPDATCVNSRTCAM---INCQYS 146
+QDV+EC C C NT SYKC C SG+ C + C C +
Sbjct: 27 AQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGY-TGDGKHCKDVDECEREDNAGCVHD 85
Query: 147 CEDTEEGPQCLCPSSGLRLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGF 206
C + +C C G LA +G +CLD+DECA G C + CVN GSY C C GF
Sbjct: 86 CVNIPGNYRCTC-YDGFHLAHDGHNCLDVDECAEGNGGC--QQSCVNMMGSYECHCREGF 142
Query: 207 ELQYISGRYDCIDINE----CTMDSHTCSHHANCFNT-QGSFKCKCKQGYK 252
L ++ CI E C +H C+H C T +G C+C+ G++
Sbjct: 143 FLS--DNQHTCIQRPEEGMNCMNKNHGCAH--ICRETPKGGIACECRPGFE 189
Score = 81.6 bits (200), Expect = 2e-15
Identities = 54/174 (31%), Positives = 79/174 (45%), Gaps = 20/174 (11%)
Query: 57 SKGVCEATCEPGCKFGECVGPNKCRCFPGYTGKTCSQDVNECGMKPRPCQHRCVNTHGSY 116
+ G C++ C C P P KTC +D++EC + C H C NT GS+
Sbjct: 243 NNGGCDSKCHDAATGVHCTCPVGFMLQPDR--KTC-KDIDECRLNNGGCDHICRNTVGSF 299
Query: 117 KCFCLSGHMLMPDATCVNSRTCAMIN-------CQYSCEDTEEGPQCLCPSSGLRLAPNG 169
+C C G+ L+ +N R C I+ C + C +T QCLC L
Sbjct: 300 ECSCKKGYKLL-----INERNCQDIDECSFDRTCDHICVNTPGSFQCLCHRGYLLYGIT- 353
Query: 170 RDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC 223
C D+DEC+ + C + C+NT GSY C C G + +G+ DC + +C
Sbjct: 354 -HCGDVDECSINRGGCRFG--CINTPGSYQCTCPAGQGRLHWNGK-DCTEPLKC 403
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/89 (33%), Positives = 41/89 (46%), Gaps = 7/89 (7%)
Query: 164 RLAPNGRDCLDIDECASGKVICPYNRRCVNTFGSYYCKCHIGFELQYISGRYDCIDINEC 223
R A + D+DEC G C + C NT SY C C G Y C D++EC
Sbjct: 19 RAAQYSKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSG----YTGDGKHCKDVDEC 74
Query: 224 TM-DSHTCSHHANCFNTQGSFKCKCKQGY 251
D+ C H +C N G+++C C G+
Sbjct: 75 EREDNAGCVH--DCVNIPGNYRCTCYDGF 101
Score = 46.6 bits (109), Expect = 6e-05
Identities = 19/45 (42%), Positives = 25/45 (55%)
Query: 219 DINECTMDSHTCSHHANCFNTQGSFKCKCKQGYKGNGLRCSAIPE 263
D++EC + C A C NT S+KC CK GY G+G C + E
Sbjct: 29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDE 73
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,557,134
Number of Sequences: 37866
Number of extensions: 1277026
Number of successful extensions: 8653
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 226
Number of HSP's that attempted gapping in prelim test: 4366
Number of HSP's gapped (non-prelim): 1778
length of query: 553
length of database: 18,247,518
effective HSP length: 107
effective length of query: 446
effective length of database: 14,195,856
effective search space: 6331351776
effective search space used: 6331351776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.