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Search of human proteins with 130980075
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|130980075 centromere protein J [Homo sapiens]
(1338 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|130980075 centromere protein J [Homo sapiens] 2680 0.0
gi|239749012 PREDICTED: hypothetical protein XP_002346880 [Homo ... 204 6e-52
gi|28416946 myosin 18A isoform a [Homo sapiens] 74 1e-12
gi|42794779 myosin 18A isoform b [Homo sapiens] 72 3e-12
gi|148746195 trichohyalin [Homo sapiens] 72 4e-12
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 70 2e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 68 7e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 68 7e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 68 7e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 68 7e-11
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 67 1e-10
gi|115495445 ankyrin repeat domain 30A [Homo sapiens] 60 1e-08
gi|55770834 centromere protein F [Homo sapiens] 59 3e-08
gi|223468602 t-complex 10-like 2 [Homo sapiens] 58 5e-08
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 58 5e-08
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 58 7e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 57 9e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 57 9e-08
gi|21389535 T-complex 10A-2 [Homo sapiens] 57 1e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 57 2e-07
gi|38044112 restin isoform b [Homo sapiens] 56 2e-07
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 56 2e-07
gi|222537750 ankyrin repeat domain 30B [Homo sapiens] 56 3e-07
gi|4758650 kinesin family member 5C [Homo sapiens] 56 3e-07
gi|105553088 t-complex 10 [Homo sapiens] 56 3e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 55 6e-07
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 54 8e-07
gi|71061468 centromere protein E [Homo sapiens] 54 8e-07
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 54 8e-07
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 1e-06
>gi|130980075 centromere protein J [Homo sapiens]
Length = 1338
Score = 2680 bits (6946), Expect = 0.0
Identities = 1338/1338 (100%), Positives = 1338/1338 (100%)
Query: 1 MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTH 60
MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTH
Sbjct: 1 MFLMPTSSELNSGQNFLTQWMTNPSRAGVILNRGFPILEADKEKRAAVDISTSFPIKGTH 60
Query: 61 FSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEE 120
FSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEE
Sbjct: 61 FSDSFSFINEEDSLLEEQKLESNNPYKPQSDKSETHTAFPCIKKGPQVAACHSAPGHQEE 120
Query: 121 NKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLT 180
NKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLT
Sbjct: 121 NKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLT 180
Query: 181 MVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHE 240
MVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHE
Sbjct: 181 MVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHE 240
Query: 241 QSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTE 300
QSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTE
Sbjct: 241 QSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTE 300
Query: 301 QIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKE 360
QIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKE
Sbjct: 301 QIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKE 360
Query: 361 AEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQL 420
AEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQL
Sbjct: 361 AEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQL 420
Query: 421 QRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKK 480
QRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKK
Sbjct: 421 QRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKK 480
Query: 481 CDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKS 540
CDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKS
Sbjct: 481 CDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKS 540
Query: 541 PIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKI 600
PIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKI
Sbjct: 541 PIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKI 600
Query: 601 LERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHS 660
LERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHS
Sbjct: 601 LERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHS 660
Query: 661 LSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTED 720
LSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTED
Sbjct: 661 LSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTED 720
Query: 721 RERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEP 780
RERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEP
Sbjct: 721 RERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEP 780
Query: 781 SRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKR 840
SRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKR
Sbjct: 781 SRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKR 840
Query: 841 KIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDN 900
KIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDN
Sbjct: 841 KIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDN 900
Query: 901 ARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIE 960
ARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIE
Sbjct: 901 ARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIE 960
Query: 961 EFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSST 1020
EFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSST
Sbjct: 961 EFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSST 1020
Query: 1021 HSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQN 1080
HSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQN
Sbjct: 1021 HSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQN 1080
Query: 1081 SQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEY 1140
SQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEY
Sbjct: 1081 SQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEY 1140
Query: 1141 KEEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQV 1200
KEEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQV
Sbjct: 1141 KEEEEDQDIQGEISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQV 1200
Query: 1201 MPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQ 1260
MPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQ
Sbjct: 1201 MPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQ 1260
Query: 1261 EESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRS 1320
EESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRS
Sbjct: 1261 EESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVYANGHQETKYRS 1320
Query: 1321 GRIRVKDKEGNVLMDTEL 1338
GRIRVKDKEGNVLMDTEL
Sbjct: 1321 GRIRVKDKEGNVLMDTEL 1338
>gi|239749012 PREDICTED: hypothetical protein XP_002346880 [Homo
sapiens]
Length = 414
Score = 204 bits (518), Expect = 6e-52
Identities = 95/146 (65%), Positives = 122/146 (83%), Gaps = 1/146 (0%)
Query: 1190 VTFFNGDVKQVMPDQRVIYYYAAAQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPD 1249
+ F NGDVK++ P +RVIYY+A AQT TTYP+GLEV+ F + Q EK YP+G KEI FPD
Sbjct: 244 IRFSNGDVKKIKPSRRVIYYHANAQTMRTTYPDGLEVVQFPNKQTEKFYPNGSKEIVFPD 303
Query: 1250 QTVKNLFPDGQEESIFPDGTIVRVQRDGNKLIEFNNGQRELHTAQFKRREYPDGTVKTVY 1309
TV++L DGQEE++FPDGTIVRV+R+G+K I +NGQ+E+HTA+FKRREYPDGTVKTVY
Sbjct: 304 GTVEHL-KDGQEETLFPDGTIVRVERNGDKTIVLSNGQKEIHTARFKRREYPDGTVKTVY 362
Query: 1310 ANGHQETKYRSGRIRVKDKEGNVLMD 1335
+G QETKY SGR+++KD+ GNV++D
Sbjct: 363 CSGCQETKYASGRVKIKDEAGNVVLD 388
Score = 42.7 bits (99), Expect = 0.002
Identities = 30/130 (23%), Positives = 58/130 (44%), Gaps = 22/130 (16%)
Query: 1153 ISHPDGKVEKVYKNGCRVILFPNGTRKEVSADGKTITVTFFNGDVKQVMPDQRVIYYYAA 1212
+ P+ + EK Y NG + I+FP+GT + + +G + + PD ++
Sbjct: 281 VQFPNKQTEKFYPNGSKEIVFPDGTVEHLK-----------DGQEETLFPDGTIV----- 324
Query: 1213 AQTTHTTYPEGLEVLHFSSGQIEKHYPDGRKEITFPDQTVKNLFPDGQEESIFPDGTIVR 1272
G + + S+GQ E H ++ +PD TVK ++ G +E+ + G +
Sbjct: 325 -----RVERNGDKTIVLSNGQKEIHTARFKRR-EYPDGTVKTVYCSGCQETKYASGRVKI 378
Query: 1273 VQRDGNKLIE 1282
GN +++
Sbjct: 379 KDEAGNVVLD 388
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 73.6 bits (179), Expect = 1e-12
Identities = 111/570 (19%), Positives = 237/570 (41%), Gaps = 69/570 (12%)
Query: 546 MKESESSLDVSLQKKLETWEREK-EKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+++ + D L + E +REK ++E L+ ++ + L +A S ++ E+D
Sbjct: 1456 LEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF---------SLKQQLEEKD 1506
Query: 605 QQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSA 664
I G ++A Q + + + ++ + R+ E++ + ++L +
Sbjct: 1507 MDIA-GFTQKVVSLEAELQDISSQESKDEASLAK-VKKQLRDLEAKVKDQEEELDEQAGT 1564
Query: 665 DELREQP-CKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRER 723
++ EQ ++ +++ + E +RD+E S +Q++V ++ ED+++
Sbjct: 1565 IQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQK 1624
Query: 724 GISSR---EDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKH-KVSE 779
+ + E D+ +D +++ R+D+ K +D +M + H K S
Sbjct: 1625 VLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK---RTKALLADAQLM--LDHLKNSA 1679
Query: 780 PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIK 839
PS+ L + E T C V ++I ++
Sbjct: 1680 PSKREIAQLKNQLEESEFT--------CAAAVKARKAMEVEIEDLHLQIDDIAKAKTALE 1731
Query: 840 RKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGD 899
+++ ++R ++ ++R +MK + + D N+L+ + +
Sbjct: 1732 EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA----- 1786
Query: 900 NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARI 959
N Q L+EK+ L++++E E + + K + R+ A + + +FE+ + K L +
Sbjct: 1787 NKEKQELQEKLQALQSQVEFL--EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESL 1844
Query: 960 EEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLRE---DLKRKETK 1016
KE M KL +ER R + +E+E+ + L++Q+ D +E +L RKE +
Sbjct: 1845 ASRLKENMEKLTEERD--------QRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAE 1896
Query: 1017 WSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKR----AEAIESSLEVEKKDKLA 1072
S L ++ L N L+ ++K+ A+KR AIE +E ++ + L
Sbjct: 1897 ASRKKHELEMDLESLEAANQSLQADLKL-------AFKRIGDLQAAIEDEMESDENEDLI 1949
Query: 1073 NTSVRFQNSQISSGTQVEKYKKNYLPMQGN 1102
N S V KY+K ++G+
Sbjct: 1950 N----------SLQDMVTKYQKRKNKLEGD 1969
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 72.4 bits (176), Expect = 3e-12
Identities = 105/542 (19%), Positives = 228/542 (42%), Gaps = 59/542 (10%)
Query: 546 MKESESSLDVSLQKKLETWEREK-EKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+++ + D L + E +REK ++E L+ ++ + L +A S ++ E+D
Sbjct: 1456 LEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAF---------SLKQQLEEKD 1506
Query: 605 QQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSA 664
I G ++A Q + + + ++ + R+ E++ + ++L +
Sbjct: 1507 MDIA-GFTQKVVSLEAELQDISSQESKDEASLAK-VKKQLRDLEAKVKDQEEELDEQAGT 1564
Query: 665 DELREQP-CKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRER 723
++ EQ ++ +++ + E +RD+E S +Q++V ++ ED+++
Sbjct: 1565 IQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQK 1624
Query: 724 GISSR---EDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKH-KVSE 779
+ + E D+ +D +++ R+D+ K +D +M + H K S
Sbjct: 1625 VLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK---RTKALLADAQLM--LDHLKNSA 1679
Query: 780 PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIK 839
PS+ L + E T C V ++I ++
Sbjct: 1680 PSKREIAQLKNQLEESEFT--------CAAAVKARKAMEVEIEDLHLQIDDIAKAKTALE 1731
Query: 840 RKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGD 899
+++ ++R ++ ++R +MK + + D N+L+ + +
Sbjct: 1732 EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA----- 1786
Query: 900 NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARI 959
N Q L+EK+ L++++E E + + K + R+ A + + +FE+ + K L +
Sbjct: 1787 NKEKQELQEKLQALQSQVEFL--EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESL 1844
Query: 960 EEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLRE---DLKRKETK 1016
KE M KL +ER R + +E+E+ + L++Q+ D +E +L RKE +
Sbjct: 1845 ASRLKENMEKLTEERD--------QRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAE 1896
Query: 1017 WSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKR----AEAIESSLEVEKKDKLA 1072
S L ++ L N L+ ++K+ A+KR AIE +E ++ + L
Sbjct: 1897 ASRKKHELEMDLESLEAANQSLQADLKL-------AFKRIGDLQAAIEDEMESDENEDLI 1949
Query: 1073 NT 1074
N+
Sbjct: 1950 NS 1951
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.0 bits (175), Expect = 4e-12
Identities = 191/1052 (18%), Positives = 402/1052 (38%), Gaps = 156/1052 (14%)
Query: 144 KKLEQLKEVQQKKQEQLKRQQLEQLQRLM---EEQEKLLTMVSGQCTLPGLSLLPDDQSQ 200
++L + +E ++++Q+QL+R+Q E+ ++ + EE+E+L + + + + Q
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE-------EERREQ 683
Query: 201 KHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRAS 260
+ ER P + + ++ + S + S + + + +R
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Query: 261 PNLFSEAQYQEAP-VEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEV 319
SE Q+QE + +EE R T + W Q +E +++ Q+ +
Sbjct: 744 ----SELQWQEEERAHRQQQEEEQRRDFTWQ----W-----QAEEKSERGRQRLSARPPL 790
Query: 320 ANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRG 379
ER ++A ER+Q + +L E+ EE+E +++Q +E E L + +Q L+R
Sbjct: 791 REQRERQLRAE--ERQQREQRFLPEE---EEKEQRRRQRREREKELQFLEEEEQ--LQRR 843
Query: 380 EGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILK 439
E + + Q+ +E + S++Q + R QL+ + + L A P L+
Sbjct: 844 ERAQQLQEEEDGLQEDQERR------RSQEQRRDQKWRWQLEEERKRRRHTLYA-KPALQ 896
Query: 440 KDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNN 499
+ + K + ++ ++ + K + ++ Q +Q+ E +
Sbjct: 897 EQLR---KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 500 KENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIR-----ETMKESESSLD 554
+E + K K Q K+ L P R + + E +E E L
Sbjct: 954 QERERQYRKD--------KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005
Query: 555 VSLQK-KLETWERE-KEKENLELDEFLFL-------------EQAADEISFSSNSSFVL- 598
+K + + WER+ ++K+ L+ +E L Q +E +L
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 599 --KILERDQQICKGHRM-------SSTPVKAVPQKTNPADPISHCNRSEDL--------- 640
+ R Q++ + +R ++ P+K + C E+L
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125
Query: 641 DHTAREKESECEVAPKQLHSLSSADE--LREQPCKIRKAVQKSTSENQTEWNARDDEGVP 698
+ + + E E ++ + +E LRE+P K R+ + E R++E +
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR--------QELERQYREEEELQ 1177
Query: 699 NSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDL 758
+ EEQ + ++RER E+ + K ED+R D+
Sbjct: 1178 QEEEQLLREEQ-----EKRRQERERQYREEEEL-----QRQKRKQRYRDEDQRSDLKWQW 1227
Query: 759 SDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNEST 818
+ ++ K + +E R L D ++ DL+ +LG +
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFR----QLEDSQLRDRQSQQDLQH-------LLGEQQE 1276
Query: 819 YGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPK 878
Q D+ + + + +K R +S +L+ + + + +
Sbjct: 1277 RDREQ---ERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Query: 879 SDSHLGNELK-LNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESA 937
+D E + L ++QP R + RE+ + + + KF E L + ER+
Sbjct: 1334 TDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL 1393
Query: 938 LEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQ 997
E+ + + EQQ ++ R +F++EE + ++ER D+K REE Q
Sbjct: 1394 KEEQQLRCQEREQQLRQD--RDRKFREEEQQLSRQER--------------DRKFREEEQ 1437
Query: 998 TLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAE 1057
+++Q +E K+ +LR + RE L +E + + R + ++
Sbjct: 1438 QVRRQ---------ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 1058 AIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGN 1117
E L +++D+ +F+ ++ S K+ + + +R + L
Sbjct: 1489 EEEQQLRRQERDR------KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 1118 LDKGQAASPREPLEPLNFPDPEYKEEEEDQDI 1149
++GQ R+ + + + ++E E+Q +
Sbjct: 1543 QERGQ--QRRQDRDRKFREEEQLRQEREEQQL 1572
Score = 60.1 bits (144), Expect = 1e-08
Identities = 171/992 (17%), Positives = 371/992 (37%), Gaps = 107/992 (10%)
Query: 106 PQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQL 165
P+ PG + K + E EG + ++LEQ ++ ++ +RQ+
Sbjct: 124 PRDRQLEEEPGQRRRQKRQ---EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEW 180
Query: 166 EQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPD 225
++ + E+E+L + C PD++ + R R
Sbjct: 181 QEREERRAEEEQLQS-----CKGHETEEFPDEEQLRRRELLELRRKGRE---------EK 226
Query: 226 PTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRN 285
Q + E+ R + VL + E +E P + L+EE
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKR--ETVLRKE-------EEKLQEEEPQRQRELQEEEEQ 277
Query: 286 -HPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEE 344
L E+ E+ Q+ + Q+ E E++ + ER++ E+ E+
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 345 QIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQ 404
Q++ E++E +++QL+ + + + ++ L+R + + + Q +E +L Q
Sbjct: 338 QLRREQEERREQQLRREQ-----EEERREQQLRREQ-----EEERREQQLRREQQLRREQ 387
Query: 405 STSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSN 464
+Q L + QQL+R+ L+ ++ L+++ + R + QK + +
Sbjct: 388 QLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 465 RKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKD 524
R + ++ + + +Q + + ++ + +E E W K + ++
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE----------RWLKLEEEE 495
Query: 525 RLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWER------EKEKENLELDEF 578
R +L + R + + LQ++L + ++ E+ ++ L+ +E
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 579 LFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSE 638
LEQ E ER Q+ K + K + + + E
Sbjct: 556 KRLEQERREQRLKREQE------ERRDQLLKREEER----RQQRLKREQEERLEQRLKRE 605
Query: 639 DLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVP 698
+++ +E+ E ++L +E R+Q K + ++ + + E R ++ +
Sbjct: 606 EVERLEQEERRE-----QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 699 NSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDL 758
+ EE+L+ +K E+ R E+ + ++ + + Q + D
Sbjct: 661 RE----EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQ 716
Query: 759 SDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVV------ 812
S K YS + + E R S + ++ER +E D
Sbjct: 717 S-KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-EEERAHRQQQEEEQRRDFTWQWQAE 774
Query: 813 ----LGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSEL-MM 867
G + P ++ +R+ + E+ + RR R EL +
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834
Query: 868 KFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASL 927
+ L+ + ++ E L Q++ R R++ + E E+ + +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR----RDQKWRWQLEEERKRRRHTLY 890
Query: 928 AKLRIERESALEKLRKEIADFEQQKAKELARIEEFKK---EEMRKLQKERKVFEKYTTAA 984
AK ++ E+LRKE Q++ +EL R E K+ E+ R+ ++E ++ ++
Sbjct: 891 AKPALQ-----EQLRKE-QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 985 RTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKV 1044
R +K+ R+E + +Q D + K ++ R R + + RE +L++E +
Sbjct: 945 REEREKRRRQERE--RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 1045 M-----ERFRLDAWKRAEAIESSLEVEKKDKL 1071
+ E+ R W+R + L+ E++ L
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLL 1034
Score = 58.2 bits (139), Expect = 5e-08
Identities = 200/1103 (18%), Positives = 422/1103 (38%), Gaps = 131/1103 (11%)
Query: 118 QEENKNDFIP-DLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQE 176
QEE++ F P D E + G + K+ EQ +E+ + +++ K+++LEQ R ++E
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQ--KRQEQERELAEGEEQSEKQERLEQRDRQRRDEE 172
Query: 177 KLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCC-FPSYVYPDPTQ---EETY 232
L Q + R + +C + +PD Q E
Sbjct: 173 ----------------LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 233 PSNILSHEQSNFCRTAHGDFVLTS-------KRASPNLFSEAQYQEA-PVEKNNLKEENR 284
E+ R D V KR + E + QE P + L+EE
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 285 N-HPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLE 343
L E+ E+ Q+ + Q+ E E++ + ER++ E+ E
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE 336
Query: 344 EQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTN 403
+Q++ E++E +++QL+ + + + +Q + E R + + Q +E +L
Sbjct: 337 QQLRREQEERREQQLRREQE----EERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 404 QSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCS 463
Q +Q L + QQL+R+ L+ ++ L+++ + R + QK + +
Sbjct: 393 QQLRREQQLRR--EQQLRREQQLRREQQ------LRREQQLRREQEEERHEQKHEQERRE 444
Query: 464 NRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGK 523
R + ++ + + +Q + + ++ + +E E W K + +
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE----------RWLKLEEE 494
Query: 524 DRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWER------EKEKENLELDE 577
+R +L + R + + LQ++L + ++ E+ ++ L+ +E
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 578 FLFLEQAADEISFSSNSSF----VLKI--------LERDQQICKGHRMSSTPVKAVPQKT 625
LEQ E +LK L+R+Q+ R+ V+ + Q+
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 626 NPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIR---------- 675
+ E+ + E + E +QL E REQ K
Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR--EQQERREQRLKREEEEERLEQRL 672
Query: 676 -------KAVQKSTSENQTEWNARDDEGVPNSDSSTDSE---EQLDVTIKPSTEDRERGI 725
+ Q+ E Q + R +P +SE Q V +P ++ +R
Sbjct: 673 KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR 732
Query: 726 SSREDSPQVCDDKGPFKDT------RTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSE 779
+E+ + + + +++ + +E++RRD ++ S S + + E
Sbjct: 733 QEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792
Query: 780 PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIK 839
R L + ++R + EE E + + E + +
Sbjct: 793 -QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK-----ELQFLEEEEQLQRRERA 846
Query: 840 RKIAPVKRG-EDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPG 898
+++ + G ++ + RRS+ + + + + + L+ + ++Q
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ--- 903
Query: 899 DNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELAR 958
Q+L+E+ EL+ E + + + R E + L++ +++ E++K + R
Sbjct: 904 -----QLLQEEEEELQREEREKRRRQEQERQYREEEQ--LQQEEEQLLREEREKRRRQER 956
Query: 959 IEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDL-KRKETKW 1017
+++K++ + ++E+ + E+ R +KK REE + +++ LRE+ KR+ +W
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 1018 SSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLA--NTS 1075
+ R + ++ E LREE E+ RL +R E L+ E++ L +
Sbjct: 1017 ERQY---RKKDELQQEEEQLLREE---REKRRLQERERQYREEEELQQEEEQLLGEERET 1070
Query: 1076 VRFQNSQISSGTQVEKYKKNYLPMQGNPPRR---SKSAPPRDLGNLDKGQAASPREPLEP 1132
R Q + + E ++ ++ P +R + R+ L + + RE E
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK 1130
Query: 1133 LNFPDPE--YKEEEEDQDIQGEI 1153
+ E Y+EEEE Q + ++
Sbjct: 1131 RRRQELERQYREEEEVQQEEEQL 1153
Score = 47.0 bits (110), Expect = 1e-04
Identities = 175/1056 (16%), Positives = 389/1056 (36%), Gaps = 138/1056 (13%)
Query: 118 QEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKR-QQLEQLQRLMEEQE 176
QEE + + L E +E + L ++ + +E Q ++++QL+R QQL + Q+L EQ+
Sbjct: 355 QEEERRE--QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 177 KLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNI 236
L + Q ++ + ER + E+
Sbjct: 413 ----------------LRREQQLRREQQLRREQEEERH----------EQKHEQERREQR 446
Query: 237 LSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWE 296
L EQ +R E + E K LK + + E
Sbjct: 447 LKREQEE-------------RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE 493
Query: 297 KVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQK 356
+ + QE ++ L++ + ++ + + + +R ++ + EQ + EQ LK++
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 357 QLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKS-KFQKGKESKLVTNQSTSEDQPLFKM 415
+ K E + ++ +R + L R + + ++ +E +L E + L +
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 416 DRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKI 475
+R++ + K +E +LK + + + + Q+ + + R+ L+
Sbjct: 614 ERREQRLKREEPEEE--RRQQLLKSEEQEERRQQQLRREQQERREQRLKREE-EEERLEQ 670
Query: 476 QTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASR 535
+ ++ + + R+Q E + + + PK W D R
Sbjct: 671 RLKREHEEERREQELAEEEQEQARERIKSRIPK------WQWQLESEADARQSKVYSRPR 724
Query: 536 LAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSS 595
R+ +E + LQ + E +++E + +F + QA ++
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784
Query: 596 FVLKIL--ERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEV 653
L +R++Q+ R Q+ P + R + + REKE +
Sbjct: 785 SARPPLREQRERQLRAEERQQRE------QRFLPEEEEKEQRRRQRRE---REKELQFLE 835
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
+QL A +L+E+ +++ ++ S+ Q R D+ + +
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ-----RRDQKWRWQLEEERKRRRHTLY 890
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESI 773
KP+ +++ R++ + +++ + R + +KRR + ++ Y +E + +
Sbjct: 891 AKPALQEQ-----LRKEQQLLQEEEEELQ--REEREKRRRQE---QERQYREEEQLQQEE 940
Query: 774 KHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGN----ESTYGTPQTCYPNN 829
+ + E + + ++ EE L + E Y +
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 830 EIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKL 889
E + ++ KR+ +R ++ E +++ + + + E +L
Sbjct: 1001 EQLLREEREKRRRQEWER----QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 890 NISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFE 949
++Q G+ RE E E + K E + ++ RE EK R++ + +
Sbjct: 1057 QQEEEQLLGEE------RETRRRQELERQYRKEEELQQEEEQLLREEP-EKRRRQERERQ 1109
Query: 950 QQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLRED 1009
++ +EL + EE E R+ ++ +++ +Y +E EE+Q ++Q+ LRE+
Sbjct: 1110 CREEEELQQEEEQLLREEREKRRRQELERQY----------REEEEVQQEEEQL--LREE 1157
Query: 1010 LKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKD 1069
++ R R +++ RE +L++E + + R + KR + E E++
Sbjct: 1158 PEK----------RRRQELERQYREEEELQQEEE--QLLREEQEKRRQERERQYREEEE- 1204
Query: 1070 KLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREP 1129
Q +K K+ Y + + P ++ D RE
Sbjct: 1205 -----------------LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGREN 1247
Query: 1130 LEPLNFPDPEYKEEEEDQDIQ---GEISHPDGKVEK 1162
+ D + ++ + QD+Q GE D + E+
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Score = 46.6 bits (109), Expect = 2e-04
Identities = 192/1057 (18%), Positives = 391/1057 (36%), Gaps = 208/1057 (19%)
Query: 139 KDPLFKKLEQL-KEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLS----- 192
KD L ++ EQL +E ++K++ Q + +Q + + L +E+E+LL L
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 193 ---LLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAH 249
L +++ P ER C +EE L E+ R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQC---------REEEE-----LQQEEEQLLREER 1128
Query: 250 GDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKN 309
KR L E QY+E E+ +EE E +L E + QE
Sbjct: 1129 ------EKRRRQEL--ERQYRE---EEEVQQEE-------EQLLREEPEKRRRQELE--- 1167
Query: 310 LQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAE-GPLPIK 368
+++ + E+ EE+ ++ +R+Q E E+ +L+ Q+ KQ+ E + L +
Sbjct: 1168 -RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 369 AKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLF----KMDRQQLQRKT 424
+P++ R + +F++ ++S+L QS + Q L + DR+Q +R+
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 425 ALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQ 484
+++ + + +++ K + SQ+ K L R+ + ++ D +
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRK--SQEEKQLLREEREEK-------RRRQETDRK 1337
Query: 485 FRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRE 544
FR+ E ++ +E P R RE
Sbjct: 1338 FRE----EEQLLQEREEQ-----------------------------PLRRQERDRKFRE 1364
Query: 545 TMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+ L+++ +E+E++ L+ ++ L ++ ++ + F E +
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKF----REEE 1420
Query: 605 QQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSA 664
QQ+ + R D RE+E + ++ L
Sbjct: 1421 QQLSRQER----------------------------DRKFREEEQQVRRQERERKFLEEE 1452
Query: 665 DELR-EQPCKIRKAVQ--KSTSENQTEWNARD------DEGVPNSDSSTDSEEQLDVTIK 715
+LR E+ K R+ Q + E Q RD ++ + + EQ + +
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 716 PSTE--DRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESI-MES 772
P + + E+ + ++ + ++ + + +R+D D+ + +E + E
Sbjct: 1513 PERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQD-----RDRKFREEEQLRQER 1567
Query: 773 IKHKVSEPSRSSSLSLSKMDF---DDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNN 829
+ ++S R L + + ER + + E+ L + G Q
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE---------GQQQ------ 1612
Query: 830 EIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFF---PSLKPKPKSDSHLGNE 886
L + RK + E L + R + E KF P L+ + + + L ++
Sbjct: 1613 ----LRQERDRKF---REDEQLLQEREEQQLHRQERDRKFLEEEPQLR-RQEREQQLRHD 1664
Query: 887 LKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIA 946
+++ Q LR + KF+ E L + ER+ E+ +
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRR-----QERDRKFREEEQQLRRQERERKFLQEEQQLRRQ 1719
Query: 947 DFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADL 1006
+ E++ +E +E ++E++R+ ++ RK+ E+ + EREE Q +Q+
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL-------RPEREEQQLRRQE---- 1768
Query: 1007 REDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVE 1066
D K +E +LR + RE LR + + +FR + R E E L +
Sbjct: 1769 -RDRKFRE------EEQLRQE-----REEQQLRSQ-ESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 1067 KKDKLANTSVRFQNSQISSGTQVEKYK----KNYLPMQGNPPRRSKSAPPRDLGNLDKGQ 1122
++D R++ Q+ Q ++ + + Y + + ++L ++ +
Sbjct: 1816 QRD----GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 1123 AASPREPLEPLNFPDPEYKEEEEDQDIQGEISHPDGK 1159
RE + KEE+ + + GEI +GK
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQRHRQV-GEIKSQEGK 1907
Score = 34.7 bits (78), Expect = 0.63
Identities = 74/442 (16%), Positives = 173/442 (39%), Gaps = 58/442 (13%)
Query: 632 SHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNA 691
+ C+ E L R++E + P+ +L E+P + R+ + E + E
Sbjct: 101 ARCDGKESLLQDRRQEEDQRRFEPRDR-------QLEEEPGQRRR---QKRQEQERELAE 150
Query: 692 RDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKG-PFKDTRTQEDK 750
+++ ++ D + ++ + R + Q+ KG ++ +E
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 751 RRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHD 810
RR L+L K + + +V + ++E+ W E L +
Sbjct: 211 RRRELLELRRKGREEKQQQRRERQDRVFQE-------------EEEKEWRKRETVLRKEE 257
Query: 811 VVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFF 870
L E + ++ L++ R+ +R E+ + +R R
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRR----ERQEEEQQQQRLRREQ--------- 304
Query: 871 PSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIEL-ETEIEKFKAENASLAK 929
L+ K + + E + + + + R Q LR + E E ++ + + E +
Sbjct: 305 -QLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Query: 930 LRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD 989
LR E+E E+++ ++L R ++ ++E+ + +++ + ++ + +
Sbjct: 364 LRREQE-------------EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410
Query: 990 KKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERF- 1048
++ R E Q ++Q ++ +R E K H + R + Q L RE + R+ +K E
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQK----HEQERRE-QRLKREQEERRDWLKREEETE 465
Query: 1049 RLDAWKRAEAIESSLEVEKKDK 1070
R + +R + ++ E E++++
Sbjct: 466 RHEQERRKQQLKRDQEEERRER 487
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 69.7 bits (169), Expect = 2e-11
Identities = 186/893 (20%), Positives = 370/893 (41%), Gaps = 143/893 (16%)
Query: 253 VLTSKRAS---PNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKN 309
+L KRA+ N + E VE+ EE +N E+ L E + + ++E +K
Sbjct: 512 ILNVKRATISWENSLEDLMEDEDLVEELENAEETQNV---ETKLLDEDLDKTLEE--NKA 566
Query: 310 LQKHDDSSEVANIEERPIKAAIGERKQ--TFEDYLEEQIQLEEQELKQKQLKEAEGPLPI 367
H++ ++ ++ E K I E+K+ T E + E++ QE Q +
Sbjct: 567 FISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVT---QEFTQYWAQR------- 616
Query: 368 KAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALK 427
+A K+ L+ E L + K K T + ++D K++ ++ LK
Sbjct: 617 EADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELK 676
Query: 428 NKELCAD------NPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKC 481
++ A+ I K+ + ++ S +L Q+ L+ SN+K ++ + +I+
Sbjct: 677 FNQIKAELAKTKGELIKTKEELKKRENESDSLIQE---LETSNKKIITQNQ-RIKELINI 732
Query: 482 DGQFRDQI-KFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKS 540
Q D I +F+N ++ EN +C DT N ++L
Sbjct: 733 IDQKEDTINEFQN--LKSHMENTFKCNDKADTSSLIIN---------------NKLICNE 775
Query: 541 PIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKI 600
+ E K+S+S + ER++ EN E DE S V
Sbjct: 776 TV-EVPKDSKSKI---------CSERKRVNEN---------ELQQDEPPAKKGSIHVSSA 816
Query: 601 LERDQQICKGHRMSSTPVK--AVPQKTNPADPISHCNRSEDLDHTAREK----------E 648
+ DQ+ + R + ++ V Q+ N +L + EK +
Sbjct: 817 ITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQ 876
Query: 649 SECEVAPKQLHSLSSADELREQPCKIRKA---VQKSTSENQTEWNARDDEGVPNSDSSTD 705
E ++ K+ +LS + + I A VQKS ++ Q E + + + S
Sbjct: 877 QELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSIT 936
Query: 706 SEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTR--TQEDKRRDVDLDLSDKDY 763
+ + + + D R + S + D +D ++ED + LDL DY
Sbjct: 937 NNVS-QIKLMHTKIDELRTLDSVSQISNI--DLLNLRDLSNGSEEDNLPNTQLDLLGNDY 993
Query: 764 SSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQ 823
+ + E +++ EP+R +S S E W + +E +V +
Sbjct: 994 LVSKQVKE---YRIQEPNRENSFHSSI-----EAIWEECKE------IVKASSKK----- 1034
Query: 824 TCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHL 883
+++I L++ I++ A VK +D + + + + ++K +L + K +
Sbjct: 1035 ----SHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQE 1090
Query: 884 GNELKLNIS-QDQPPGDNARSQVL------REKIIELETEIEKFKAENASLAKLR---IE 933
N + L++ Q G A S++ + KI ELET +E K E + AKL +E
Sbjct: 1091 KN-VTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILE 1149
Query: 934 RESALEKLRKEIADFEQ------QKAKELARIEEFK-KEEMRKLQKERKVFEKYTTAART 986
+ES + KL + + +F++ + K+L ++E K KEE+ +L + K+ +
Sbjct: 1150 KESIILKLERNLKEFQEHLQDSVKNTKDL-NVKELKLKEEITQLTNNLQDM-KHLLQLKE 1207
Query: 987 FPDKKEREEIQTLKQQIA-------DLREDLKRKETKWSSTHSRL---RSQIQMLVRENT 1036
++ R+E + LK++++ +L+ DL+RKE ++ +L + QI+ + +E +
Sbjct: 1208 EEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVS 1267
Query: 1037 DLREEIKVMERFRLDAWKRAEAIESSLEVEKKDK-LANTSVRFQNSQISSGTQ 1088
+R+E K++ R +++ ++ + + S E++ K + + + N ++ Q
Sbjct: 1268 VMRDEDKLL-RIKINELEKKKN-QCSQELDMKQRTIQQLKEQLNNQKVEEAIQ 1318
Score = 43.9 bits (102), Expect = 0.001
Identities = 122/645 (18%), Positives = 243/645 (37%), Gaps = 155/645 (24%)
Query: 539 KSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFL-----FLEQAADEISFSSN 593
KS E +++ L ++ + R KEKE+ D+ L ++Q +E+ N
Sbjct: 1034 KSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQ-EKN 1092
Query: 594 SSFVLKILERDQQICKGHRMSSTPVKAVP---QKTNPADPISH-----CNRSEDLDHTAR 645
+ ++I Q + +G R S + V K + I C+ S L+
Sbjct: 1093 VTLDVQI----QHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDIL 1148
Query: 646 EKES-----ECEVAPKQLH---SLSSADELREQPCKIRKAVQKSTS------------EN 685
EKES E + Q H S+ + +L + K+++ + + T+ E
Sbjct: 1149 EKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEE 1208
Query: 686 QTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTR 745
+ E N ++ E + S++ + Q +K + +E + ++ ++ D K K +
Sbjct: 1209 EEETNRQETEKLKEELSASSARTQ---NLKADLQRKEEDYADLKE--KLTDAKKQIKQVQ 1263
Query: 746 TQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEEN 805
+ RD D + ++ K++E + + ++D +RT L+E
Sbjct: 1264 KEVSVMRDED---------------KLLRIKINELEKKKNQCSQELDMK-QRTIQQLKEQ 1307
Query: 806 LCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSEL 865
L N V + E D +K KI ED+ +
Sbjct: 1308 LNNQKV-----------EEAIQQYERACKDLNVKEKII-----EDMRMT----------- 1340
Query: 866 MMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELE---TEIEKFKA 922
L + + + QDQ VL K+ E+E TE+EK+K
Sbjct: 1341 -----------------LEEQEQTQVEQDQ---------VLEAKLEEVERLATELEKWKE 1374
Query: 923 ENASLAKLRIERES--------ALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKER 974
+ L +R + L KL + ++ + K A +++ +E+M + + +
Sbjct: 1375 KCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAK 1434
Query: 975 -------KVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQ 1027
K +KY F K++ E++ L Q+ + DL++ + + L Q
Sbjct: 1435 EAENIRNKEMKKYAEDRERF--FKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQ 1492
Query: 1028 IQMLVRENTDLREEIKVMERFRLDAWK---------------------RAEAIESSLEVE 1066
++ L+ N EI+ ++R + K + E + +S E+
Sbjct: 1493 LKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEI- 1551
Query: 1067 KKDKLANTSVRFQNSQISS-GTQVEKYKKNYLPMQGNPPRRSKSA 1110
++K+ + SV + ++S+ Q ++ K L +Q P + +K A
Sbjct: 1552 SRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMA 1596
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 67.8 bits (164), Expect = 7e-11
Identities = 192/952 (20%), Positives = 367/952 (38%), Gaps = 154/952 (16%)
Query: 276 KNNLKEENRNHP--TGESILCWEKV---TEQIQEANDKNLQKHDDSSEVANI-------- 322
+N LKE + H T E L E++ TE EA + ++ E+ I
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 323 --EERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGE 380
EE + ERK+ + L+ + QLEE+E +++L+ + K K + + +
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 381 GLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPI--- 437
+ + K + + S L TN + E ++ + T LKNK + +
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEE---------EKAKNLTKLKNKHESMISELEVR 1042
Query: 438 LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP-----SGLKIQTGKKCD------GQFR 486
LKK+ K+R + L +K + + ++ + LK+Q KK + +
Sbjct: 1043 LKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 487 DQIKFENKVTSNNKE---NVTECPKPCDTGCTGWN----------------KTQGKDRLP 527
D+I +N +E ++++ + D+ N KT+ +D L
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 528 LSTGPASRLAAK-----SPIRETMKESESSLDVSLQ--------------KKLETWEREK 568
ST L AK + +++ + E S + +Q ++LE ++R K
Sbjct: 1161 -STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 569 ----------EKENLEL-DEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTP 617
EKEN +L E L QA E+ ++ E + G R +
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAEL 1278
Query: 618 VKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSS----ADELREQPCK 673
V + N E + E E + K + SLSS EL ++ +
Sbjct: 1279 NDKVHKLQNEV---------ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 674 IRKAVQKSTSENQTEWNARDDEGVPNSDSS--------------TDSEEQLD---VTIKP 716
+ V + + E N+ D+ ++ +DS+++L T++
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 717 STEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHK 776
E ++R E+ Q ++K D + R +LD D + ++ +++ K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 777 VSE----PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEI- 831
+ + ++S D D E+ + E + N++
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 832 -GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKS--DSHLGNELK 888
++ + K K +L KS+R+ E+ + L+ + ++ D+ L E+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVN 1568
Query: 889 LNISQDQPPGD-NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIAD 947
+ + Q D AR + EK +L+ ++ +++ E K R +A +KL ++ D
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 948 FEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD------KKEREEIQTLKQ 1001
E Q + EE K ++RKLQ + K F++ AR D K+ ++ ++L+
Sbjct: 1629 LELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 1002 QIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFR---LDAWKRAEA 1058
+ L+EDL E R R Q + E +L EE+ R D +R EA
Sbjct: 1688 DLMQLQEDLAAAE--------RARKQADL---EKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1059 IESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSA 1110
+ LE E +++ N + + ++ TQ + N L + + ++++SA
Sbjct: 1737 RIAQLEEELEEEQGN--MEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 50.4 bits (119), Expect = 1e-05
Identities = 186/962 (19%), Positives = 366/962 (38%), Gaps = 115/962 (11%)
Query: 119 EENKNDFIPDLASEFKEGAYKDPLFKKLEQL---KEVQQKKQEQLKRQQLEQLQRLMEEQ 175
EE +D +LA E ++ L K E + EV+ KK+E+ RQ+LE+L+R +E
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK-SRQELEKLKRKLEGD 1063
Query: 176 -----EKLLTMVSGQCTLP------------GLSLLPDDQSQKHRSPGNTTTGERATCCF 218
E++ + + L L+ L D+ +QK+ N R
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN----NALKKIRELEGH 1119
Query: 219 PSYVYPDPTQEETYPSNILSH-----EQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAP 273
S + D E + E+ +T D L S L ++ + QE
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE-QEVT 1177
Query: 274 VEKNNLKEENRNHPTGESIL------CWEKVTEQIQEAN--DKNLQKHDDSSEVANIEER 325
V K L EE R+H + E++TEQ+++ NL K+ + E N +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 326 PIKAAIGERKQTFEDYLEEQIQLEEQELKQK--QLKEAEGPLPIKAKPKQPFLKRGEGLA 383
+G+ KQ E + +++++ + QEL+ K + A L K Q ++ G+
Sbjct: 1238 GELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 384 RFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSK 443
K+ + K+ +++Q + L + RQ+L T L+ E ++ + D +
Sbjct: 1297 NEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 444 ARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-----FENKVTSN 498
K + ++K L ++ ++ +F+ +I+ +E K +
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 499 NK---------ENVTECPKPCDTGCTGWNKTQGKDR-----LPLSTGPASRLAAKSPIRE 544
+K + + + D + + K R L +S+ A + E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 545 TMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+ + +SL + LE E + KE LE + + D +S + + LE+
Sbjct: 1476 AEAREKETKALSLARALE--EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 605 QQICKGH----RMSSTPVKAVPQKTNPADPISHCNRS-------EDLDHTAREKESECEV 653
++ + + ++ Q T A N DL + E +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
+QLH + E + + A +K + + + D + + + +L
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSD--KDYSSDESIME 771
+K + E +SR++ F + E K + ++ DL +D ++ E +
Sbjct: 1654 MKDFQRELEDARASRDEI---------FATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 772 SIKHKVSEPSRSSSLSLSKMDF--DDERTWT--------DLEENLCNHDVVLGNESTYGT 821
+ E + + SLS + D++R +LEE N + + + T
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKAT 1763
Query: 822 PQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDS 881
Q +NE+ T ++ + ++ E +K RS+ + + ++K K KS +
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSK-------LHEMEGAVKSKFKS-T 1815
Query: 882 HLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKL 941
E K+ ++Q Q REK + T+ K K + L++E E + +
Sbjct: 1816 IAALEAKIAQLEEQV------EQEAREK--QAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQ 1001
KE A+ + K+L R E +EE +++ R+ ++ A T ++ E+ LK
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-TESNEAMGREVNALKS 1926
Query: 1002 QI 1003
++
Sbjct: 1927 KL 1928
Score = 49.7 bits (117), Expect = 2e-05
Identities = 192/1018 (18%), Positives = 372/1018 (36%), Gaps = 217/1018 (21%)
Query: 258 RASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSS 317
+ P L Q +E +++ L++ E+ L E + Q +KNL + +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898
Query: 318 EVA-NIEERPIKAAIGERKQTFEDYLEE-QIQLEEQELKQKQL-----KEAEGPLPIKAK 370
E E ++ + +KQ E+ L E + +LEE+E + +QL K A+ L ++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 371 PKQPFLKRGEGLARFTNAKSKFQKGKESKLVT---NQSTSEDQPLFKM-----------D 416
++ R + A++K +K ++ LV N S+++ L + +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 417 RQQLQRKTALKNKELCADNPI---LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP--- 470
++ + T LKNK + + LKK+ K+R + L +K + + ++
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQA 1076
Query: 471 --SGLKIQTGKKCD------GQFRDQIKFENKVTSNNKE---NVTECPKPCDTGCTGWNK 519
+ LK+Q KK + + D+I +N +E ++++ + D+ NK
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 520 ----------------TQGKDRLPLSTGPASRLAAK-----SPIRETMKESESSLDVSLQ 558
T+ +D L ST L AK + +++ + E S + +Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 559 K--------------KLETWEREK----------EKENLEL-DEFLFLEQAADEISFSSN 593
+ +LE ++R K EKEN +L E L QA E+
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 594 SSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEV 653
++ E + G R + V + N + ++ E E +
Sbjct: 1256 K-LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM---------LNEAEGKAIK 1305
Query: 654 APKQLHSLSS----ADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQ 709
K + SLSS EL ++ + + V + + E N+ D+ ++ + E
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 710 LDV-----------------TIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR 752
+ T++ E ++R E+ Q ++K D + R
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 753 DVDLDLSDKDYSSDESIMESIKHKVSE----PSRSSSLSLSKMDFDDERTWTDLEENLCN 808
+LD D + ++ +++ K + + ++S D D E+
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 809 HDVVLGNESTYGTPQTCYPNNEI--GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELM 866
+ E + N++ ++ + K K +L KS+R+ E+
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 867 MKFFPSLKPKPKS--DSHLGNELKLNISQDQPPGD-NARSQVLREKIIELETEIEKFKAE 923
+ L+ + ++ D+ L E+ + + Q D AR + EK +L+ ++ +++ E
Sbjct: 1546 TQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 924 NASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTA 983
K R +A +KL ++ D E Q + EE K+ +RKLQ + K F++
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELED 1663
Query: 984 ARTFPD----------KK---------------------------EREEI---------- 996
AR D KK E+EE+
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 997 --------QTLKQQIADLREDLKRKETKWSSTHSRLR----------------------- 1025
+ L+ +IA L E+L+ ++ + R+R
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 1026 -SQIQMLVRENTDLREEIKVMERFRLDAWKRAEA--------IESSLEVEKKDKLANT 1074
S Q L R+N +LR ++ ME +K A +E +E E ++K A T
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/286 (22%), Positives = 120/286 (41%), Gaps = 47/286 (16%)
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
E ++ + DQ + ++L E+I +L T + + + + +L KL+ + ES + +L +
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
E++ +EL +++ RKL+ + F E+I L+ QIA+
Sbjct: 1044 KK-EEKSRQELEKLK-------RKLEGDASDF---------------HEQIADLQAQIAE 1080
Query: 1006 LREDLKRKETKWSSTHSRLRSQ----------IQMLVRENTDLREEIKVMERFRLDAWKR 1055
L+ L +KE + + +RL + I+ L +DL+E++ R A K+
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1056 AEAIESSLE---VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPP 1112
+ LE E +D L +T+ + Q + +V KK + RS A
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKAL-----DEETRSHEAQV 1194
Query: 1113 RDLGNLDKGQAASPREPLEPL-----NFPDPEYKEEEEDQDIQGEI 1153
+++ E LE N + E+E+ D+ GE+
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 67.8 bits (164), Expect = 7e-11
Identities = 192/952 (20%), Positives = 367/952 (38%), Gaps = 154/952 (16%)
Query: 276 KNNLKEENRNHP--TGESILCWEKV---TEQIQEANDKNLQKHDDSSEVANI-------- 322
+N LKE + H T E L E++ TE EA + ++ E+ I
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 323 --EERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGE 380
EE + ERK+ + L+ + QLEE+E +++L+ + K K + + +
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 381 GLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPI--- 437
+ + K + + S L TN + E ++ + T LKNK + +
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEE---------EKAKNLTKLKNKHESMISELEVR 1049
Query: 438 LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP-----SGLKIQTGKKCD------GQFR 486
LKK+ K+R + L +K + + ++ + LK+Q KK + +
Sbjct: 1050 LKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 487 DQIKFENKVTSNNKE---NVTECPKPCDTGCTGWN----------------KTQGKDRLP 527
D+I +N +E ++++ + D+ N KT+ +D L
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 528 LSTGPASRLAAK-----SPIRETMKESESSLDVSLQ--------------KKLETWEREK 568
ST L AK + +++ + E S + +Q ++LE ++R K
Sbjct: 1168 -STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 569 ----------EKENLEL-DEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTP 617
EKEN +L E L QA E+ ++ E + G R +
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 618 VKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSS----ADELREQPCK 673
V + N E + E E + K + SLSS EL ++ +
Sbjct: 1286 NDKVHKLQNEV---------ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 674 IRKAVQKSTSENQTEWNARDDEGVPNSDSS--------------TDSEEQLD---VTIKP 716
+ V + + E N+ D+ ++ +DS+++L T++
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 717 STEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHK 776
E ++R E+ Q ++K D + R +LD D + ++ +++ K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 777 VSE----PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEI- 831
+ + ++S D D E+ + E + N++
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 832 -GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKS--DSHLGNELK 888
++ + K K +L KS+R+ E+ + L+ + ++ D+ L E+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVN 1575
Query: 889 LNISQDQPPGD-NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIAD 947
+ + Q D AR + EK +L+ ++ +++ E K R +A +KL ++ D
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 948 FEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD------KKEREEIQTLKQ 1001
E Q + EE K ++RKLQ + K F++ AR D K+ ++ ++L+
Sbjct: 1636 LELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 1002 QIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFR---LDAWKRAEA 1058
+ L+EDL E R R Q + E +L EE+ R D +R EA
Sbjct: 1695 DLMQLQEDLAAAE--------RARKQADL---EKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1059 IESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSA 1110
+ LE E +++ N + + ++ TQ + N L + + ++++SA
Sbjct: 1744 RIAQLEEELEEEQGN--MEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 50.4 bits (119), Expect = 1e-05
Identities = 186/962 (19%), Positives = 366/962 (38%), Gaps = 115/962 (11%)
Query: 119 EENKNDFIPDLASEFKEGAYKDPLFKKLEQL---KEVQQKKQEQLKRQQLEQLQRLMEEQ 175
EE +D +LA E ++ L K E + EV+ KK+E+ RQ+LE+L+R +E
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK-SRQELEKLKRKLEGD 1070
Query: 176 -----EKLLTMVSGQCTLP------------GLSLLPDDQSQKHRSPGNTTTGERATCCF 218
E++ + + L L+ L D+ +QK+ N R
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN----NALKKIRELEGH 1126
Query: 219 PSYVYPDPTQEETYPSNILSH-----EQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAP 273
S + D E + E+ +T D L S L ++ + QE
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE-QEVT 1184
Query: 274 VEKNNLKEENRNHPTGESIL------CWEKVTEQIQEAN--DKNLQKHDDSSEVANIEER 325
V K L EE R+H + E++TEQ+++ NL K+ + E N +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 326 PIKAAIGERKQTFEDYLEEQIQLEEQELKQK--QLKEAEGPLPIKAKPKQPFLKRGEGLA 383
+G+ KQ E + +++++ + QEL+ K + A L K Q ++ G+
Sbjct: 1245 GELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 384 RFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSK 443
K+ + K+ +++Q + L + RQ+L T L+ E ++ + D +
Sbjct: 1304 NEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 444 ARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-----FENKVTSN 498
K + ++K L ++ ++ +F+ +I+ +E K +
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 499 NK---------ENVTECPKPCDTGCTGWNKTQGKDR-----LPLSTGPASRLAAKSPIRE 544
+K + + + D + + K R L +S+ A + E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 545 TMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+ + +SL + LE E + KE LE + + D +S + + LE+
Sbjct: 1483 AEAREKETKALSLARALE--EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 605 QQICKGH----RMSSTPVKAVPQKTNPADPISHCNRS-------EDLDHTAREKESECEV 653
++ + + ++ Q T A N DL + E +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
+QLH + E + + A +K + + + D + + + +L
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSD--KDYSSDESIME 771
+K + E +SR++ F + E K + ++ DL +D ++ E +
Sbjct: 1661 MKDFQRELEDARASRDEI---------FATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 772 SIKHKVSEPSRSSSLSLSKMDF--DDERTWT--------DLEENLCNHDVVLGNESTYGT 821
+ E + + SLS + D++R +LEE N + + + T
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKAT 1770
Query: 822 PQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDS 881
Q +NE+ T ++ + ++ E +K RS+ + + ++K K KS +
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSK-------LHEMEGAVKSKFKS-T 1822
Query: 882 HLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKL 941
E K+ ++Q Q REK + T+ K K + L++E E + +
Sbjct: 1823 IAALEAKIAQLEEQV------EQEAREK--QAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQ 1001
KE A+ + K+L R E +EE +++ R+ ++ A T ++ E+ LK
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-TESNEAMGREVNALKS 1933
Query: 1002 QI 1003
++
Sbjct: 1934 KL 1935
Score = 49.7 bits (117), Expect = 2e-05
Identities = 192/1018 (18%), Positives = 372/1018 (36%), Gaps = 217/1018 (21%)
Query: 258 RASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSS 317
+ P L Q +E +++ L++ E+ L E + Q +KNL + +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905
Query: 318 EVA-NIEERPIKAAIGERKQTFEDYLEE-QIQLEEQELKQKQL-----KEAEGPLPIKAK 370
E E ++ + +KQ E+ L E + +LEE+E + +QL K A+ L ++ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 371 PKQPFLKRGEGLARFTNAKSKFQKGKESKLVT---NQSTSEDQPLFKM-----------D 416
++ R + A++K +K ++ LV N S+++ L + +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 417 RQQLQRKTALKNKELCADNPI---LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP--- 470
++ + T LKNK + + LKK+ K+R + L +K + + ++
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQA 1083
Query: 471 --SGLKIQTGKKCD------GQFRDQIKFENKVTSNNKE---NVTECPKPCDTGCTGWNK 519
+ LK+Q KK + + D+I +N +E ++++ + D+ NK
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 520 ----------------TQGKDRLPLSTGPASRLAAK-----SPIRETMKESESSLDVSLQ 558
T+ +D L ST L AK + +++ + E S + +Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 559 K--------------KLETWEREK----------EKENLEL-DEFLFLEQAADEISFSSN 593
+ +LE ++R K EKEN +L E L QA E+
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 594 SSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEV 653
++ E + G R + V + N + ++ E E +
Sbjct: 1263 K-LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM---------LNEAEGKAIK 1312
Query: 654 APKQLHSLSS----ADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQ 709
K + SLSS EL ++ + + V + + E N+ D+ ++ + E
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 710 LDV-----------------TIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR 752
+ T++ E ++R E+ Q ++K D + R
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 753 DVDLDLSDKDYSSDESIMESIKHKVSE----PSRSSSLSLSKMDFDDERTWTDLEENLCN 808
+LD D + ++ +++ K + + ++S D D E+
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 809 HDVVLGNESTYGTPQTCYPNNEI--GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELM 866
+ E + N++ ++ + K K +L KS+R+ E+
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 867 MKFFPSLKPKPKS--DSHLGNELKLNISQDQPPGD-NARSQVLREKIIELETEIEKFKAE 923
+ L+ + ++ D+ L E+ + + Q D AR + EK +L+ ++ +++ E
Sbjct: 1553 TQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 924 NASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTA 983
K R +A +KL ++ D E Q + EE K+ +RKLQ + K F++
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELED 1670
Query: 984 ARTFPD----------KK---------------------------EREEI---------- 996
AR D KK E+EE+
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 997 --------QTLKQQIADLREDLKRKETKWSSTHSRLR----------------------- 1025
+ L+ +IA L E+L+ ++ + R+R
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 1026 -SQIQMLVRENTDLREEIKVMERFRLDAWKRAEA--------IESSLEVEKKDKLANT 1074
S Q L R+N +LR ++ ME +K A +E +E E ++K A T
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/286 (22%), Positives = 120/286 (41%), Gaps = 47/286 (16%)
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
E ++ + DQ + ++L E+I +L T + + + + +L KL+ + ES + +L +
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
E++ +EL +++ RKL+ + F E+I L+ QIA+
Sbjct: 1051 KK-EEKSRQELEKLK-------RKLEGDASDF---------------HEQIADLQAQIAE 1087
Query: 1006 LREDLKRKETKWSSTHSRLRSQ----------IQMLVRENTDLREEIKVMERFRLDAWKR 1055
L+ L +KE + + +RL + I+ L +DL+E++ R A K+
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1056 AEAIESSLE---VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPP 1112
+ LE E +D L +T+ + Q + +V KK + RS A
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKAL-----DEETRSHEAQV 1201
Query: 1113 RDLGNLDKGQAASPREPLEPL-----NFPDPEYKEEEEDQDIQGEI 1153
+++ E LE N + E+E+ D+ GE+
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 67.8 bits (164), Expect = 7e-11
Identities = 192/952 (20%), Positives = 367/952 (38%), Gaps = 154/952 (16%)
Query: 276 KNNLKEENRNHP--TGESILCWEKV---TEQIQEANDKNLQKHDDSSEVANI-------- 322
+N LKE + H T E L E++ TE EA + ++ E+ I
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 323 --EERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGE 380
EE + ERK+ + L+ + QLEE+E +++L+ + K K + + +
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 381 GLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPI--- 437
+ + K + + S L TN + E ++ + T LKNK + +
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEE---------EKAKNLTKLKNKHESMISELEVR 1049
Query: 438 LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP-----SGLKIQTGKKCD------GQFR 486
LKK+ K+R + L +K + + ++ + LK+Q KK + +
Sbjct: 1050 LKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 487 DQIKFENKVTSNNKE---NVTECPKPCDTGCTGWN----------------KTQGKDRLP 527
D+I +N +E ++++ + D+ N KT+ +D L
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167
Query: 528 LSTGPASRLAAK-----SPIRETMKESESSLDVSLQ--------------KKLETWEREK 568
ST L AK + +++ + E S + +Q ++LE ++R K
Sbjct: 1168 -STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 569 ----------EKENLEL-DEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTP 617
EKEN +L E L QA E+ ++ E + G R +
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 618 VKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSS----ADELREQPCK 673
V + N E + E E + K + SLSS EL ++ +
Sbjct: 1286 NDKVHKLQNEV---------ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336
Query: 674 IRKAVQKSTSENQTEWNARDDEGVPNSDSS--------------TDSEEQLD---VTIKP 716
+ V + + E N+ D+ ++ +DS+++L T++
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 717 STEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHK 776
E ++R E+ Q ++K D + R +LD D + ++ +++ K
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456
Query: 777 VSE----PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEI- 831
+ + ++S D D E+ + E + N++
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1516
Query: 832 -GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKS--DSHLGNELK 888
++ + K K +L KS+R+ E+ + L+ + ++ D+ L E+
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVN 1575
Query: 889 LNISQDQPPGD-NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIAD 947
+ + Q D AR + EK +L+ ++ +++ E K R +A +KL ++ D
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 948 FEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD------KKEREEIQTLKQ 1001
E Q + EE K ++RKLQ + K F++ AR D K+ ++ ++L+
Sbjct: 1636 LELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1694
Query: 1002 QIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFR---LDAWKRAEA 1058
+ L+EDL E R R Q + E +L EE+ R D +R EA
Sbjct: 1695 DLMQLQEDLAAAE--------RARKQADL---EKEELAEELASSLSGRNALQDEKRRLEA 1743
Query: 1059 IESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSA 1110
+ LE E +++ N + + ++ TQ + N L + + ++++SA
Sbjct: 1744 RIAQLEEELEEEQGN--MEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Score = 50.4 bits (119), Expect = 1e-05
Identities = 186/962 (19%), Positives = 366/962 (38%), Gaps = 115/962 (11%)
Query: 119 EENKNDFIPDLASEFKEGAYKDPLFKKLEQL---KEVQQKKQEQLKRQQLEQLQRLMEEQ 175
EE +D +LA E ++ L K E + EV+ KK+E+ RQ+LE+L+R +E
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK-SRQELEKLKRKLEGD 1070
Query: 176 -----EKLLTMVSGQCTLP------------GLSLLPDDQSQKHRSPGNTTTGERATCCF 218
E++ + + L L+ L D+ +QK+ N R
Sbjct: 1071 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN----NALKKIRELEGH 1126
Query: 219 PSYVYPDPTQEETYPSNILSH-----EQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAP 273
S + D E + E+ +T D L S L ++ + QE
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE-QEVT 1184
Query: 274 VEKNNLKEENRNHPTGESIL------CWEKVTEQIQEAN--DKNLQKHDDSSEVANIEER 325
V K L EE R+H + E++TEQ+++ NL K+ + E N +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 326 PIKAAIGERKQTFEDYLEEQIQLEEQELKQK--QLKEAEGPLPIKAKPKQPFLKRGEGLA 383
+G+ KQ E + +++++ + QEL+ K + A L K Q ++ G+
Sbjct: 1245 GELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 384 RFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSK 443
K+ + K+ +++Q + L + RQ+L T L+ E ++ + D +
Sbjct: 1304 NEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 444 ARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-----FENKVTSN 498
K + ++K L ++ ++ +F+ +I+ +E K +
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 499 NK---------ENVTECPKPCDTGCTGWNKTQGKDR-----LPLSTGPASRLAAKSPIRE 544
+K + + + D + + K R L +S+ A + E
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1482
Query: 545 TMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+ + +SL + LE E + KE LE + + D +S + + LE+
Sbjct: 1483 AEAREKETKALSLARALE--EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 605 QQICKGH----RMSSTPVKAVPQKTNPADPISHCNRS-------EDLDHTAREKESECEV 653
++ + + ++ Q T A N DL + E +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
+QLH + E + + A +K + + + D + + + +L
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSD--KDYSSDESIME 771
+K + E +SR++ F + E K + ++ DL +D ++ E +
Sbjct: 1661 MKDFQRELEDARASRDEI---------FATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 772 SIKHKVSEPSRSSSLSLSKMDF--DDERTWT--------DLEENLCNHDVVLGNESTYGT 821
+ E + + SLS + D++R +LEE N + + + T
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKAT 1770
Query: 822 PQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDS 881
Q +NE+ T ++ + ++ E +K RS+ + + ++K K KS +
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSK-------LHEMEGAVKSKFKS-T 1822
Query: 882 HLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKL 941
E K+ ++Q Q REK + T+ K K + L++E E + +
Sbjct: 1823 IAALEAKIAQLEEQV------EQEAREK--QAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874
Query: 942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQ 1001
KE A+ + K+L R E +EE +++ R+ ++ A T ++ E+ LK
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-TESNEAMGREVNALKS 1933
Query: 1002 QI 1003
++
Sbjct: 1934 KL 1935
Score = 49.7 bits (117), Expect = 2e-05
Identities = 192/1018 (18%), Positives = 372/1018 (36%), Gaps = 217/1018 (21%)
Query: 258 RASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSS 317
+ P L Q +E +++ L++ E+ L E + Q +KNL + +
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 905
Query: 318 EVA-NIEERPIKAAIGERKQTFEDYLEE-QIQLEEQELKQKQL-----KEAEGPLPIKAK 370
E E ++ + +KQ E+ L E + +LEE+E + +QL K A+ L ++ +
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 371 PKQPFLKRGEGLARFTNAKSKFQKGKESKLVT---NQSTSEDQPLFKM-----------D 416
++ R + A++K +K ++ LV N S+++ L + +
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 417 RQQLQRKTALKNKELCADNPI---LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP--- 470
++ + T LKNK + + LKK+ K+R + L +K + + ++
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQA 1083
Query: 471 --SGLKIQTGKKCD------GQFRDQIKFENKVTSNNKE---NVTECPKPCDTGCTGWNK 519
+ LK+Q KK + + D+I +N +E ++++ + D+ NK
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 520 ----------------TQGKDRLPLSTGPASRLAAK-----SPIRETMKESESSLDVSLQ 558
T+ +D L ST L AK + +++ + E S + +Q
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 559 K--------------KLETWEREK----------EKENLEL-DEFLFLEQAADEISFSSN 593
+ +LE ++R K EKEN +L E L QA E+
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 594 SSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEV 653
++ E + G R + V + N + ++ E E +
Sbjct: 1263 K-LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM---------LNEAEGKAIK 1312
Query: 654 APKQLHSLSS----ADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQ 709
K + SLSS EL ++ + + V + + E N+ D+ ++ + E
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 710 LDV-----------------TIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR 752
+ T++ E ++R E+ Q ++K D + R
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1432
Query: 753 DVDLDLSDKDYSSDESIMESIKHKVSE----PSRSSSLSLSKMDFDDERTWTDLEENLCN 808
+LD D + ++ +++ K + + ++S D D E+
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 809 HDVVLGNESTYGTPQTCYPNNEI--GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELM 866
+ E + N++ ++ + K K +L KS+R+ E+
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 867 MKFFPSLKPKPKS--DSHLGNELKLNISQDQPPGD-NARSQVLREKIIELETEIEKFKAE 923
+ L+ + ++ D+ L E+ + + Q D AR + EK +L+ ++ +++ E
Sbjct: 1553 TQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1611
Query: 924 NASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTA 983
K R +A +KL ++ D E Q + EE K+ +RKLQ + K F++
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELED 1670
Query: 984 ARTFPD----------KK---------------------------EREEI---------- 996
AR D KK E+EE+
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 997 --------QTLKQQIADLREDLKRKETKWSSTHSRLR----------------------- 1025
+ L+ +IA L E+L+ ++ + R+R
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 1026 -SQIQMLVRENTDLREEIKVMERFRLDAWKRAEA--------IESSLEVEKKDKLANT 1074
S Q L R+N +LR ++ ME +K A +E +E E ++K A T
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/286 (22%), Positives = 120/286 (41%), Gaps = 47/286 (16%)
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
E ++ + DQ + ++L E+I +L T + + + + +L KL+ + ES + +L +
Sbjct: 991 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1050
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
E++ +EL +++ RKL+ + F E+I L+ QIA+
Sbjct: 1051 KK-EEKSRQELEKLK-------RKLEGDASDF---------------HEQIADLQAQIAE 1087
Query: 1006 LREDLKRKETKWSSTHSRLRSQ----------IQMLVRENTDLREEIKVMERFRLDAWKR 1055
L+ L +KE + + +RL + I+ L +DL+E++ R A K+
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1056 AEAIESSLE---VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPP 1112
+ LE E +D L +T+ + Q + +V KK + RS A
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKAL-----DEETRSHEAQV 1201
Query: 1113 RDLGNLDKGQAASPREPLEPL-----NFPDPEYKEEEEDQDIQGEI 1153
+++ E LE N + E+E+ D+ GE+
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 67.8 bits (164), Expect = 7e-11
Identities = 192/952 (20%), Positives = 367/952 (38%), Gaps = 154/952 (16%)
Query: 276 KNNLKEENRNHP--TGESILCWEKV---TEQIQEANDKNLQKHDDSSEVANI-------- 322
+N LKE + H T E L E++ TE EA + ++ E+ I
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 323 --EERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGE 380
EE + ERK+ + L+ + QLEE+E +++L+ + K K + + +
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 381 GLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPI--- 437
+ + K + + S L TN + E ++ + T LKNK + +
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEE---------EKAKNLTKLKNKHESMISELEVR 1042
Query: 438 LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP-----SGLKIQTGKKCD------GQFR 486
LKK+ K+R + L +K + + ++ + LK+Q KK + +
Sbjct: 1043 LKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 487 DQIKFENKVTSNNKE---NVTECPKPCDTGCTGWN----------------KTQGKDRLP 527
D+I +N +E ++++ + D+ N KT+ +D L
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160
Query: 528 LSTGPASRLAAK-----SPIRETMKESESSLDVSLQ--------------KKLETWEREK 568
ST L AK + +++ + E S + +Q ++LE ++R K
Sbjct: 1161 -STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 569 ----------EKENLEL-DEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTP 617
EKEN +L E L QA E+ ++ E + G R +
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAEL 1278
Query: 618 VKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSS----ADELREQPCK 673
V + N E + E E + K + SLSS EL ++ +
Sbjct: 1279 NDKVHKLQNEV---------ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329
Query: 674 IRKAVQKSTSENQTEWNARDDEGVPNSDSS--------------TDSEEQLD---VTIKP 716
+ V + + E N+ D+ ++ +DS+++L T++
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 717 STEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHK 776
E ++R E+ Q ++K D + R +LD D + ++ +++ K
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449
Query: 777 VSE----PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEI- 831
+ + ++S D D E+ + E + N++
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKML 1509
Query: 832 -GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKS--DSHLGNELK 888
++ + K K +L KS+R+ E+ + L+ + ++ D+ L E+
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ-LEELEDELQATEDAKLRLEVN 1568
Query: 889 LNISQDQPPGD-NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIAD 947
+ + Q D AR + EK +L+ ++ +++ E K R +A +KL ++ D
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 948 FEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPD------KKEREEIQTLKQ 1001
E Q + EE K ++RKLQ + K F++ AR D K+ ++ ++L+
Sbjct: 1629 LELQADSAIKGREEAIK-QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA 1687
Query: 1002 QIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFR---LDAWKRAEA 1058
+ L+EDL E R R Q + E +L EE+ R D +R EA
Sbjct: 1688 DLMQLQEDLAAAE--------RARKQADL---EKEELAEELASSLSGRNALQDEKRRLEA 1736
Query: 1059 IESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSA 1110
+ LE E +++ N + + ++ TQ + N L + + ++++SA
Sbjct: 1737 RIAQLEEELEEEQGN--MEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Score = 50.4 bits (119), Expect = 1e-05
Identities = 186/962 (19%), Positives = 366/962 (38%), Gaps = 115/962 (11%)
Query: 119 EENKNDFIPDLASEFKEGAYKDPLFKKLEQL---KEVQQKKQEQLKRQQLEQLQRLMEEQ 175
EE +D +LA E ++ L K E + EV+ KK+E+ RQ+LE+L+R +E
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK-SRQELEKLKRKLEGD 1063
Query: 176 -----EKLLTMVSGQCTLP------------GLSLLPDDQSQKHRSPGNTTTGERATCCF 218
E++ + + L L+ L D+ +QK+ N R
Sbjct: 1064 ASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN----NALKKIRELEGH 1119
Query: 219 PSYVYPDPTQEETYPSNILSH-----EQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAP 273
S + D E + E+ +T D L S L ++ + QE
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELED-TLDSTATQQELRAKRE-QEVT 1177
Query: 274 VEKNNLKEENRNHPTGESIL------CWEKVTEQIQEAN--DKNLQKHDDSSEVANIEER 325
V K L EE R+H + E++TEQ+++ NL K+ + E N +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 326 PIKAAIGERKQTFEDYLEEQIQLEEQELKQK--QLKEAEGPLPIKAKPKQPFLKRGEGLA 383
+G+ KQ E + +++++ + QEL+ K + A L K Q ++ G+
Sbjct: 1238 GELRVLGQAKQEVE-HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 384 RFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSK 443
K+ + K+ +++Q + L + RQ+L T L+ E ++ + D +
Sbjct: 1297 NEAEGKA-IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 444 ARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-----FENKVTSN 498
K + ++K L ++ ++ +F+ +I+ +E K +
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 499 NK---------ENVTECPKPCDTGCTGWNKTQGKDR-----LPLSTGPASRLAAKSPIRE 544
+K + + + D + + K R L +S+ A + E
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAE 1475
Query: 545 TMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERD 604
+ + +SL + LE E + KE LE + + D +S + + LE+
Sbjct: 1476 AEAREKETKALSLARALE--EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 605 QQICKGH----RMSSTPVKAVPQKTNPADPISHCNRS-------EDLDHTAREKESECEV 653
++ + + ++ Q T A N DL + E +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
+QLH + E + + A +K + + + D + + + +L
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSD--KDYSSDESIME 771
+K + E +SR++ F + E K + ++ DL +D ++ E +
Sbjct: 1654 MKDFQRELEDARASRDEI---------FATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 772 SIKHKVSEPSRSSSLSLSKMDF--DDERTWT--------DLEENLCNHDVVLGNESTYGT 821
+ E + + SLS + D++R +LEE N + + + T
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA-MSDRVRKAT 1763
Query: 822 PQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDS 881
Q +NE+ T ++ + ++ E +K RS+ + + ++K K KS +
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSK-------LHEMEGAVKSKFKS-T 1815
Query: 882 HLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKL 941
E K+ ++Q Q REK + T+ K K + L++E E + +
Sbjct: 1816 IAALEAKIAQLEEQV------EQEAREK--QAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867
Query: 942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQ 1001
KE A+ + K+L R E +EE +++ R+ ++ A T ++ E+ LK
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA-TESNEAMGREVNALKS 1926
Query: 1002 QI 1003
++
Sbjct: 1927 KL 1928
Score = 49.7 bits (117), Expect = 2e-05
Identities = 192/1018 (18%), Positives = 372/1018 (36%), Gaps = 217/1018 (21%)
Query: 258 RASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSS 317
+ P L Q +E +++ L++ E+ L E + Q +KNL + +
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQA 898
Query: 318 EVA-NIEERPIKAAIGERKQTFEDYLEE-QIQLEEQELKQKQL-----KEAEGPLPIKAK 370
E E ++ + +KQ E+ L E + +LEE+E + +QL K A+ L ++ +
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 371 PKQPFLKRGEGLARFTNAKSKFQKGKESKLVT---NQSTSEDQPLFKM-----------D 416
++ R + A++K +K ++ LV N S+++ L + +
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 417 RQQLQRKTALKNKELCADNPI---LKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSP--- 470
++ + T LKNK + + LKK+ K+R + L +K + + ++
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK--LKRKLEGDASDFHEQIADLQA 1076
Query: 471 --SGLKIQTGKKCD------GQFRDQIKFENKVTSNNKE---NVTECPKPCDTGCTGWNK 519
+ LK+Q KK + + D+I +N +E ++++ + D+ NK
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 520 ----------------TQGKDRLPLSTGPASRLAAK-----SPIRETMKESESSLDVSLQ 558
T+ +D L ST L AK + +++ + E S + +Q
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLD-STATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 559 K--------------KLETWEREK----------EKENLEL-DEFLFLEQAADEISFSSN 593
+ +LE ++R K EKEN +L E L QA E+
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 594 SSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEV 653
++ E + G R + V + N + ++ E E +
Sbjct: 1256 K-LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM---------LNEAEGKAIK 1305
Query: 654 APKQLHSLSS----ADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQ 709
K + SLSS EL ++ + + V + + E N+ D+ ++ + E
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 710 LDV-----------------TIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR 752
+ T++ E ++R E+ Q ++K D + R
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRL 1425
Query: 753 DVDLDLSDKDYSSDESIMESIKHKVSE----PSRSSSLSLSKMDFDDERTWTDLEENLCN 808
+LD D + ++ +++ K + + ++S D D E+
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 809 HDVVLGNESTYGTPQTCYPNNEI--GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELM 866
+ E + N++ ++ + K K +L KS+R+ E+
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 867 MKFFPSLKPKPKS--DSHLGNELKLNISQDQPPGD-NARSQVLREKIIELETEIEKFKAE 923
+ L+ + ++ D+ L E+ + + Q D AR + EK +L+ ++ +++ E
Sbjct: 1546 TQL-EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE 1604
Query: 924 NASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTA 983
K R +A +KL ++ D E Q + EE K+ +RKLQ + K F++
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ-LRKLQAQMKDFQRELED 1663
Query: 984 ARTFPD----------KK---------------------------EREEI---------- 996
AR D KK E+EE+
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 997 --------QTLKQQIADLREDLKRKETKWSSTHSRLR----------------------- 1025
+ L+ +IA L E+L+ ++ + R+R
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 1026 -SQIQMLVRENTDLREEIKVMERFRLDAWKRAEA--------IESSLEVEKKDKLANT 1074
S Q L R+N +LR ++ ME +K A +E +E E ++K A T
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841
Score = 43.9 bits (102), Expect = 0.001
Identities = 63/286 (22%), Positives = 120/286 (41%), Gaps = 47/286 (16%)
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
E ++ + DQ + ++L E+I +L T + + + + +L KL+ + ES + +L +
Sbjct: 984 EDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL 1043
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
E++ +EL +++ RKL+ + F E+I L+ QIA+
Sbjct: 1044 KK-EEKSRQELEKLK-------RKLEGDASDF---------------HEQIADLQAQIAE 1080
Query: 1006 LREDLKRKETKWSSTHSRLRSQ----------IQMLVRENTDLREEIKVMERFRLDAWKR 1055
L+ L +KE + + +RL + I+ L +DL+E++ R A K+
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1056 AEAIESSLE---VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPP 1112
+ LE E +D L +T+ + Q + +V KK + RS A
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQ-QELRAKREQEVTVLKKAL-----DEETRSHEAQV 1194
Query: 1113 RDLGNLDKGQAASPREPLEPL-----NFPDPEYKEEEEDQDIQGEI 1153
+++ E LE N + E+E+ D+ GE+
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 67.0 bits (162), Expect = 1e-10
Identities = 198/1011 (19%), Positives = 393/1011 (38%), Gaps = 153/1011 (15%)
Query: 151 EVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTT 210
EV ++ E+ + Q+ QL+ L++E++K L Q + L ++ RS G
Sbjct: 744 EVSIQRTEKALKDQINQLELLLKERDKHLK--EHQAHVENL------EADIKRSEGELQQ 795
Query: 211 GERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQ 270
F SY Q + Y + +Q + +L +K Q
Sbjct: 796 ASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL--DLETERILLTK----------QVA 843
Query: 271 EAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAA 330
E +K ++ E H +V + +Q+ +N + + + E ++
Sbjct: 844 EVEAQKKDVCTELDAHKI--------QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895
Query: 331 IGERKQTFEDYLEEQ---IQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTN 387
E++QT + +E++ +Q+ E + K+ ++ + + AK + E +F N
Sbjct: 896 NKEQEQTKQILVEKENMILQMREGQKKEIEILTQK----LSAKEDSIHILNEEYETKFKN 951
Query: 388 AKSKF----QKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSK 443
+ K QK KE + + + + K + + + + K K+ A + + +
Sbjct: 952 QEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 444 ARTKSGSVTLSQKPK----MLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNN 499
A L K L +R+ L+ I +K Q ++++ +++
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDV---ISIWEKKLNQQAEELQEIHEIQLQE 1068
Query: 500 KEN-VTE---------CPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKES 549
KE V E C K W K +G + +L KS ++ +
Sbjct: 1069 KEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128
Query: 550 ESSLDVSLQKKLETWEREKEKENLELDEFLF-LEQAADEISFS-SNSSFVLKILERDQQI 607
E+ L L+K LE + KEN L E L L+ A+E S + LK + + Q
Sbjct: 1129 ETKLKAHLEK-LEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQS 1187
Query: 608 CKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSA--- 664
K S K++ K+ +S + LD ++ E+ E +L ++SS+
Sbjct: 1188 LKSSHEKSN--KSLEDKSLEFKKLSE-ELAIQLDICCKKTEALLEAKTNELINISSSKTN 1244
Query: 665 ------DELREQPCKIRKAVQ-KSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPS 717
+ + K+++A+ K+ + ++ E R T+ + L+++ + +
Sbjct: 1245 AILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQ---------LTEEQNTLNISFQQA 1295
Query: 718 T---EDRERGISS-REDSPQVCDDKGPFKD---TRTQEDKRRDVDLDLSDKDYSSDESIM 770
T E++E I S + D + +K + + Q ++ + K+ S + + +
Sbjct: 1296 THQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAV 1355
Query: 771 ESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNE 830
+K ++ E S SLSK TDL L N + E+ + + Y +
Sbjct: 1356 TLMKEELKEKKVEIS-SLSKQ-------LTDLNVQLQNSISLSEKEAAISSLRKQYDEEK 1407
Query: 831 IGILDKT----------IKRKIAPVKRGEDLS-------KSRRSR----SPPTSELMMKF 869
+LD+ K KI+ +++ +D S K +SR EL ++
Sbjct: 1408 CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQL 1467
Query: 870 FPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQV------LREKIIELETEIEKFKAE 923
K + D + N LK + Q D + ++ + +K LETE++ A
Sbjct: 1468 ELKSKEAYEKDEQI-NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTAR 1526
Query: 924 NASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTA 983
L ++ +E L + + ++ QQK E KE ++KLQ +++ E+
Sbjct: 1527 IMELEDHITQKTIEIESLNEVLKNYNQQKDIE-------HKELVQKLQHFQELGEEKDNR 1579
Query: 984 ARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIK 1043
K+ E+I TL+ Q+ ++ +L+ K+ + + ++S+ EE+K
Sbjct: 1580 V-----KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK-----------EEELK 1623
Query: 1044 VMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKK 1094
+E RL++ A+ E + E+K + Q + + E+YKK
Sbjct: 1624 ALED-RLESESAAKLAELKRKAEQKIAAIKKQLLSQMEE-----KEEQYKK 1668
Score = 45.1 bits (105), Expect = 5e-04
Identities = 182/979 (18%), Positives = 392/979 (40%), Gaps = 138/979 (14%)
Query: 139 KDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQ 198
+D +++ +L+E Q Q+ K Q E+ +EE+++ ++++ Q +SLL +
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQ-EEFDASLEEKDQYISVLQTQ-----VSLL---K 232
Query: 199 SQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVL---T 255
+ P N + P P E + + + E++ + G+ V+ T
Sbjct: 233 QRLRNGPMNVDV-----------LKPLPQLEPQ--AEVFTKEENP---ESDGEPVVEDGT 276
Query: 256 SKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDD 315
S + L + QE +++ KE ++H ++L EK E +QE D+ LQ+ +
Sbjct: 277 SVKTLETLQQRVKRQENLLKR--CKETIQSHKEQCTLLTSEK--EALQEQLDERLQELEK 332
Query: 316 SSEVANIEERPIKAAIGERKQTFEDYLEEQ----IQLEEQELKQKQLKEAEGPLPIKAKP 371
++ E+ + + + K E +++ + + Q + ++KE E ++++
Sbjct: 333 IKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEE-IAQLRSRI 391
Query: 372 KQPFLKRGEGLA--RFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNK 429
KQ +GE L + + ++ F++ E L T Q T E + K + + Q KT K
Sbjct: 392 KQ-MTTQGEELREQKEKSERAAFEE-LEKALSTAQKTEEARRKLKAEMDE-QIKTIEKTS 448
Query: 430 ELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGL---------KIQTGKK 480
E + I + +R K V + +K + + + L L K+QT ++
Sbjct: 449 E---EERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 481 CDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKS 540
+F++Q+K + + + +++ + ++ + Q K L S L ++
Sbjct: 506 ---EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEA 562
Query: 541 PIRET-MKESESSLDVSLQKKLET-------WEREKEKENLELDEFLFLEQAADEISFSS 592
T + E ESSL+ SLQ+ E EK K N E+ + +E+ E+
Sbjct: 563 ETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT--VMVEKHKTELESLK 620
Query: 593 NSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECE 652
+ L Q+ K + T ++ + +K E+E E
Sbjct: 621 HQQDAL--WTEKLQVLK--QQYQTEMEKLREKC--------------------EQEKETL 656
Query: 653 VAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDV 712
+ K++ + +E+ E K ++K QTE + E + EE+L V
Sbjct: 657 LKDKEIIFQAHIEEMNE------KTLEK-LDVKQTELESLSSELSEVLKARHKLEEELSV 709
Query: 713 TIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMES 772
+K T+ ++ + ++ D + K + K +V + ++K + +E
Sbjct: 710 -LKDQTDKMKQELEAKMD-----EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLEL 763
Query: 773 IKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIG 832
+ + + + + ++ D +R+ +L++ DV +S Y
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQ 823
Query: 833 ILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSEL-------------MMKFFPSLKPKPKS 879
+ K + + + + +++ + +EL + K ++ K KS
Sbjct: 824 LQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS 883
Query: 880 DSHL-------GNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRI 932
+ + GN+ + Q +N Q+ + E+E +K A+ S+ L
Sbjct: 884 LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE 943
Query: 933 ERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKE 992
E E+ + K++ + +QKAKE+ E KK+ + + K +K E +
Sbjct: 944 EYETKFKNQEKKM-EKVKQKAKEMQ--ETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Query: 993 REEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVR-ENTDLREEIKVMERFRLD 1051
+ ++ + A + + + R ET + QI+ L +L + I + E+ +L+
Sbjct: 1001 AKMLEMAQANSAGISDAVSRLET-------NQKEQIESLTEVHRRELNDVISIWEK-KLN 1052
Query: 1052 AWKRAEAIESSLEVEKKDK 1070
++AE ++ E++ ++K
Sbjct: 1053 --QQAEELQEIHEIQLQEK 1069
Score = 44.3 bits (103), Expect = 8e-04
Identities = 128/606 (21%), Positives = 238/606 (39%), Gaps = 104/606 (17%)
Query: 556 SLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILER--DQQIC--KGH 611
S++ +LET ++E E NL + E A E S S+ L L+R +Q+I K
Sbjct: 1596 SMKAELETKKKELEHVNLSVKS-KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 612 RMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQP 671
+S K K +S N +E+E E + ++L
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTK------LQEREREVHILEEKL------------- 1695
Query: 672 CKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDS 731
K+V+ S SE + + DS+ + T + +R ++ +E
Sbjct: 1696 ----KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKL 1751
Query: 732 PQ-VCDDKGPFKDTRTQ---EDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLS 787
Q V +K + + + + R + L+ ++ D+S++ ++ ++ E ++ SL
Sbjct: 1752 LQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI 1811
Query: 788 LSK-MDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIG--ILDKTIK----- 839
+++ ++ + + ++NL E+ + Q E+ IL++ IK
Sbjct: 1812 VAQHVEKEGGKNNIQAKQNL---------ENVFDDVQKTLQEKELTCQILEQKIKELDSC 1862
Query: 840 ----RKIAPVKRGEDLSKSRR--------SRSPPTSELMMKFFPSLKPKPKSDSHLGNEL 887
+++ V+ E SK + R+ PT EL+ + + KS SHL
Sbjct: 1863 LVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT-ELLEE-----NTEEKSKSHLVQPK 1916
Query: 888 KLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAK----LRIERESALEKLRK 943
L+ + A+ L K+ E E +K E L K LR E + LE L+K
Sbjct: 1917 LLSNME-------AQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKK 1969
Query: 944 EIADFEQQKAKELARIEEFK-----KEEMRKL--QKERKVFEKYTTAARTFPDKKE---- 992
E ++K K+ E K K+ MR+ Q +K E T T +E
Sbjct: 1970 EYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAE 2029
Query: 993 -----REEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMER 1047
+EE L ++IA+ +DLKR ++ ++ VR+ EE++ +
Sbjct: 2030 LLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQ 2089
Query: 1048 FRLDAWK-----RAEAIESSLEVEKKDKLANTS----VRFQNSQISSGTQVEKYKKN-YL 1097
+L+ + +E ++ +K L + S F+ + +++KY+KN Y
Sbjct: 2090 QKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149
Query: 1098 PMQGNP 1103
G P
Sbjct: 2150 TTVGTP 2155
Score = 42.7 bits (99), Expect = 0.002
Identities = 209/1202 (17%), Positives = 433/1202 (36%), Gaps = 142/1202 (11%)
Query: 29 VILNRGFPILEADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKP 88
++L + +EA K+ D+ T D + +++S +E++ Y+
Sbjct: 836 ILLTKQVAEVEAQKK-----DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYES 890
Query: 89 Q---SDKSETHTAFPCIKKGPQVAACHSAPGHQEE-------NKNDFIPDLASEFKEGAY 138
+ +K + T ++K + + E K D I L E+ E +
Sbjct: 891 KLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEY-ETKF 949
Query: 139 KDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQ 198
K+ KK+E++K+ ++ QE LK++ L+Q +L +E E +S + +L Q
Sbjct: 950 KNQE-KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQ 1008
Query: 199 SQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKR 258
+ S G + R + Q+E S H + + + L +
Sbjct: 1009 A---NSAGISDAVSRL----------ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA 1055
Query: 259 ASPNLFSEAQYQEAPVEKNNLKEE------NRNHPTGESILCWEKVTEQIQEANDKNLQK 312
E Q QE E LK++ + E E+ +Q N+ Q
Sbjct: 1056 EELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Query: 313 HDDSSEVANI--EERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAK 370
S+ V ++ +E +KA + + + L+E L+EQ ++ K L E +
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK------- 1168
Query: 371 PKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKE 430
K E ++ +FQ K S +N+S + FK +L + A++
Sbjct: 1169 -----RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK----KLSEELAIQLDI 1219
Query: 431 LCADNPIL--KKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQ--TGKKCDGQFR 486
C L K ++ S S T + ++ C +R + L I+ T + + Q R
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 487 DQIKFENKVTSN---------NKENVTECPKPCDTGCT---------GWNKTQGKDR--- 525
+ +N + + KEN + K G N+ Q
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKES 1339
Query: 526 --LPLSTGPASRLAAKSPIRETMKESE----------SSLDVSLQKKLETWEREKEKENL 573
L + + A + ++E +KE + + L+V LQ + E+E +L
Sbjct: 1340 CITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSL 1399
Query: 574 EL---DEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADP 630
+E L ++SF ++ KI +Q ++ S KA + T +
Sbjct: 1400 RKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNT 1459
Query: 631 ISHCNRSEDL-DHTAREKESECEVAPKQLHSLSSA-DELREQPCKIRKAVQKSTSENQTE 688
+ +L A EK+ + + ++L + D L+ + + ++K S +TE
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETE 1519
Query: 689 WNARDDEGVPNSDSSTDSE---EQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTR 745
++ + D T E L+ +K + ++ Q + G KD R
Sbjct: 1520 LKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR 1579
Query: 746 TQEDKRR-----------DVDLDLSDKDYS----SDESIMESIKHKVSEPSRSSSLSLSK 790
+E + + +L+ K+ S +S E +K S+ L++
Sbjct: 1580 VKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAE 1639
Query: 791 MDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGED 850
+ E+ +++ L + + GT + + L+ ++ + V E+
Sbjct: 1640 LKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT------ESHLSELNTKLQEREREVHILEE 1693
Query: 851 LSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQ---PPGDNARSQVLR 907
KS S T + P+S ++ + + Q + VL+
Sbjct: 1694 KLKSVESSQSETLIV-----------PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ 1742
Query: 908 EKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEM 967
+ E E +++ E E ++ ++ E ++ ++ + I ++E
Sbjct: 1743 RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELE 1802
Query: 968 RKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQ 1027
K +K + ++ K + Q L+ D+++ L+ KE +++
Sbjct: 1803 EKNKKYSLIVAQHVEKE---GGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859
Query: 1028 IQMLVRENTDLREEIKVM--ERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISS 1085
LVR+ R E++ + + +L A ++ + E+ +++ + ++ S
Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919
Query: 1086 GTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKEEEE 1145
+ + N L + R K +++ L K +E + L EY +E E
Sbjct: 1920 NMEAQ---HNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQERE 1976
Query: 1146 DQ 1147
++
Sbjct: 1977 EK 1978
Score = 38.9 bits (89), Expect = 0.033
Identities = 55/308 (17%), Positives = 131/308 (42%), Gaps = 49/308 (15%)
Query: 855 RRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELE 914
+R R+ P + ++K P L+P + ++ ++ P D E ++E
Sbjct: 233 QRLRNGPMNVDVLKPLPQLEP----------QAEVFTKEENPESDG-------EPVVEDG 275
Query: 915 TEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEM-RKLQKE 973
T ++ + + R++R+ L K KE +++ L +E +E++ +LQ+
Sbjct: 276 TSVKTLET-----LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL 330
Query: 974 RKVFEKYTTA----------ARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSR 1023
K+ + + A+ ++ E+++ + + + E L+ KE + + +
Sbjct: 331 EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIA----Q 386
Query: 1024 LRSQIQMLVRENTDLREEIKVMERFRLDAWKRA-------EAIESSLEVEKKDKLANTSV 1076
LRS+I+ + + +LRE+ + ER + ++A E L+ E +++
Sbjct: 387 LRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 1077 RFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNL-DKGQAASPREPLEPLNF 1135
+ +IS ++ + K+ + + ++S L L +K A +E + L
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVM----KKSSEEQIAKLQKLHEKELARKEQELTKKLQT 502
Query: 1136 PDPEYKEE 1143
+ E++E+
Sbjct: 503 REREFQEQ 510
Score = 38.9 bits (89), Expect = 0.033
Identities = 176/974 (18%), Positives = 370/974 (37%), Gaps = 171/974 (17%)
Query: 39 EADKEKRAAVDISTSFPIKGTHFSDSFSFINEEDSLLEEQKLESNNPYKPQSDKS-ETHT 97
E +++AA + + S++ + + L+E+K+E ++ K +D + +
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 98 AFPCIKKGPQVAACHSAPGHQEENKNDFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQ 157
+ +K +++ ++ D + DL+ FK LEQ+ + K
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLS--FKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 158 EQLKRQQ--LEQLQRLMEEQEKLLTMVSGQCTLPG--LSLLPDDQSQKHRSPGNTTTGER 213
E K+ Q Q Q ++E + L + S + ++LL ++ Q+++
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFD------- 1496
Query: 214 ATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAP 273
C + D ++ E SN+ + +S R + +T K +E
Sbjct: 1497 ---CLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE------- 1546
Query: 274 VEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGE 333
V KN ++++ H + ++ + +++ E D +++ ++ + +KA +
Sbjct: 1547 VLKNYNQQKDIEH---KELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET 1603
Query: 334 RKQTFEDYLEEQIQLEEQELKQKQLK-EAEGPLPI-----KAKPKQPFLKRGEGLARFTN 387
+K+ E ++ ++ +E+ELK + + E+E + KA+ K +K+ + L++
Sbjct: 1604 KKKELE-HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKK-QLLSQMEE 1661
Query: 388 AKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTK 447
+ +++KG ES L +L K + +E+ IL++ K
Sbjct: 1662 KEEQYKKGTESHL-----------------SELNTKLQEREREV----HILEEKLK---- 1696
Query: 448 SGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECP 507
SV SQ ++ + K+++ ++ D Q Q +E K+ S + N+TE
Sbjct: 1697 --SVESSQSETLIVPRSAKNVAA----YTEQEEADSQGCVQKTYEEKI-SVLQRNLTE-- 1747
Query: 508 KPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWERE 567
K++L G +E S + Q++L E
Sbjct: 1748 ---------------KEKLLQRVGQE---------KEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 568 KEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNP 627
+ K++ + L++ +E N + L + + V+ K N
Sbjct: 1784 EAKQHEDQSMIGHLQEELEE----KNKKYSLIVAQH--------------VEKEGGKNNI 1825
Query: 628 ADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQT 687
+ N +D+ T +EKE C++ +++ L S C +R Q
Sbjct: 1826 QAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDS--------CLVR----------QK 1867
Query: 688 EWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQ 747
E + + E + + + +Q+D KP TE E + S V K
Sbjct: 1868 EVHRVEMEELTSKYEKLQALQQMDGRNKP-TELLEENTEEKSKSHLVQP-----KLLSNM 1921
Query: 748 EDKRRDVDLDLS----DKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDER---TWT 800
E + D++ L+ +K E + ++ L + K ++D ER
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ 1981
Query: 801 DLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSP 860
+ E+ H+ L Q E L+ TIK I + E ++ S
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQE---LEMTIKETINKAQEVE--AELLESHQE 2036
Query: 861 PTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKF 920
T++L+ K + ++LK + + D AR + + K+ +L+T++E+
Sbjct: 2037 ETNQLLKKI-----------AEKDDDLKRTAKRYEEILD-AREEEMTAKVRDLQTQLEEL 2084
Query: 921 KAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFK------KEEMRKLQKER 974
+ + + ++E+E I + + Q A++ I + K +E++ L+
Sbjct: 2085 QKK----YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRL 2140
Query: 975 KVFEK--YTTAART 986
K +EK Y T T
Sbjct: 2141 KKYEKNVYATTVGT 2154
Score = 38.1 bits (87), Expect = 0.057
Identities = 47/224 (20%), Positives = 97/224 (43%), Gaps = 21/224 (9%)
Query: 886 ELKLNISQDQPPGDNARSQVLREK---IIELETEIEKFKAENASLAKLRIERESALEKLR 942
+L+ I Q G+ R Q + + ELE + + + KL+ E + ++ +
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Query: 943 KEIADFEQQKAKELARIEE-----FKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQ 997
K + +EL+R+++ KK ++ K +K+ EK +KE+E +
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA-------RKEQELTK 498
Query: 998 TLKQQIADLREDLKRKETKWSSTH---SRLRSQIQMLVRENTDLREE--IKVMERFRLDA 1052
L+ + + +E +K K S + S+ + Q + L E +L+++ + E D
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558
Query: 1053 WKRAEAIESS-LEVEKKDKLANTSVRFQNSQISSGTQVEKYKKN 1095
+ AE + LE+E + + + Q+ ++ + EK K N
Sbjct: 559 QQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
>gi|115495445 ankyrin repeat domain 30A [Homo sapiens]
Length = 1341
Score = 60.5 bits (145), Expect = 1e-08
Identities = 144/701 (20%), Positives = 263/701 (37%), Gaps = 108/701 (15%)
Query: 410 QPLFKMDRQQLQRKTALKNKELCADNPILKKDSKAR--------TKSGSVTLSQKPKML- 460
+P +M + LKN++ +P+ +SK + ++S T+SQK L
Sbjct: 468 KPAIEMQNSVPNKAFELKNEQTLRADPMFPPESKQKDYEENSWDSESLCETVSQKDVCLP 527
Query: 461 KCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKT 520
K +++K + K++ DG K T K ++ T +
Sbjct: 528 KATHQKEIDKINGKLEESPNKDGLL--------KATCGMKVSIPTKALELKDMQTFKAEP 579
Query: 521 QGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLF 580
GK P + PA+ + P + ++E +L + L + ++K+ E D
Sbjct: 580 PGK---PSAFEPATEMQKSVPNKALELKNEQTLRAD--EILPSESKQKDYEENSWDTESL 634
Query: 581 LEQAADEISFSSNSSFVLKILERDQQICK-GHRMSSTPVKAVPQKTNPADPISHCNRSED 639
E S L ++I K ++ +PVK K N +S ++ +
Sbjct: 635 CETV-------SQKDVCLPKAAHQKEIDKINGKLEGSPVKDGLLKANCGMKVSIPTKALE 687
Query: 640 LDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPN 699
L K P++ + A E++ K+V E + E R DE +P+
Sbjct: 688 LMDMQTFKAEP----PEKPSAFEPAIEMQ-------KSVPNKALELKNEQTLRADEILPS 736
Query: 700 SDSSTDSEE-------------QLDVTIKPSTEDRE--RGISSREDSPQVCDDKGPFKDT 744
D EE Q DV + +T +E + E+SP D+ G K
Sbjct: 737 ESKQKDYEESSWDSESLCETVSQKDVCLPKATHQKEIDKINGKLEESP---DNDGFLKAP 793
Query: 745 RTQEDKRRDVDLDLSDKDYSSDE------------SIMESIKHKVSEPSRSSSLSLSKMD 792
+ L+L D E + +S+ +K E +L +M
Sbjct: 794 CRMKVSIPTKALELMDMQTFKAEPPEKPSAFEPAIEMQKSVPNKALELKNEQTLRADQM- 852
Query: 793 FDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPN-------NEIG--ILDKTIKRKIA 843
F E +EEN + + + T C P ++I + D T KI
Sbjct: 853 FPSESKQKKVEENSWDSESL---RETVSQKDVCVPKATHQKEMDKISGKLEDSTSLSKIL 909
Query: 844 PV----KRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNEL------------ 887
+R +L K + E M K F LK K + ++L
Sbjct: 910 DTVHSCERARELQKDHCEQRTGKMEQMKKKFCVLKKKLSEAKEIKSQLENQKVKWEQELC 969
Query: 888 --KLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
+L ++Q++ NA +L EKI E IE+ + + K ++E+ ++ + +
Sbjct: 970 SVRLTLNQEEEKRRNA--DILNEKIREELGRIEEQHRKELEV-KQQLEQALRIQDIELKS 1026
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFE-KYTTAARTFPDKKER--EEIQTLKQQ 1002
+ + E + E L+KE + + + T + +K+ + E+I+ LK++
Sbjct: 1027 VESNLNQVSHTHENENYLLHENCMLKKEIAMLKLEIATLKHQYQEKENKYFEDIKILKEK 1086
Query: 1003 IADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIK 1043
A+L+ LK KE + S+ Q+++L+ ENT L ++K
Sbjct: 1087 NAELQMTLKLKEESLTKRASQYSGQLKVLIAENTMLTSKLK 1127
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 58.9 bits (141), Expect = 3e-08
Identities = 189/1029 (18%), Positives = 401/1029 (38%), Gaps = 135/1029 (13%)
Query: 145 KLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSL-LPDDQSQKHR 203
+L+ L+ QK++++++ ++ E E Q + S + T +S L +SQ +
Sbjct: 40 QLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNF 99
Query: 204 SPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQS-NFCRTAHGDFVLTSKRASPN 262
G +G++ + ++ E S + S N C T F T+
Sbjct: 100 QEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIF--TTPLTPSQ 157
Query: 263 LFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEA--NDKNLQKHDDSSEV- 319
+S ++Y++ + N EE + L +K ++ + +A N +++ +H SS V
Sbjct: 158 YYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVF 217
Query: 320 ------------ANIEERPIKA--------------------AIGER--KQTFED----- 340
+N + PI+ IG+R +F D
Sbjct: 218 SWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSP 277
Query: 341 YLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGK---- 396
+L +Q++ + QEL+ K + E E L ++ K+ +G+ + +F + + +K K
Sbjct: 278 HLLDQLKAQNQELRNK-INELE--LRLQGHEKE---MKGQ-VNKFQELQLQLEKAKVELI 330
Query: 397 ESKLVTNQSTSEDQPLFKMDRQQLQRKTAL--KNKELCADNPILKKDSKARTKSGSVTLS 454
E + V N+ E Q + TAL K K+L D +++++ S +L
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAE----SARCSLE 386
Query: 455 QKPKMLKCSNRKSLSPSGLKIQT-GKKCDG------QFRDQIKFENKVTSNNKENVTECP 507
QK K + ++ LS QT ++C Q Q K + V + +T
Sbjct: 387 QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK 446
Query: 508 KPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWERE 567
+ + + + + + + E KE+ S QK E E
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 568 KEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNP 627
E +N++ ++ S N + +K Q+ T ++ + +K N
Sbjct: 507 AELKNIK-----------QCLNQSQNFAEEMKAKNTSQE---------TMLRDLQEKINQ 546
Query: 628 ADPISHCNRSEDLDHTAREKESEC--EVAPKQLHSLSSADELREQPCKIRKAVQKSTSEN 685
+ + + L EK+ +C ++ K+ H + ++ + K KA+ +
Sbjct: 547 QENSLTLEKLK-LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 686 QTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTR 745
+ E+ +E S +++E+ L E + + S+ + + C K
Sbjct: 606 KKEYEELKEEKTLFSCWKSENEKLLT-----QMESEKENLQSKINHLETCLKTQQIKSHE 660
Query: 746 TQEDKRR-DVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEE 804
E R ++D + + + ++++S +V + K +F D++ ++E
Sbjct: 661 YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIE- 719
Query: 805 NLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSE 864
N+C L + + +NEI D+ + A + DL KS+ + S T+E
Sbjct: 720 NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA-SLVTNE 778
Query: 865 LMMKFFPSLKPKPKSDSHLGNEL-----------KLNISQDQPPGDNARSQVLREKIIEL 913
+ + +P N + + + DQ P ++A +L+ ++ L
Sbjct: 779 DHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSA---ILQNRVDSL 835
Query: 914 ETEIEKFKAENASLAK-------LRIERESALEKLRKEIADFEQQKAKELARIEEFKKEE 966
E +E K N+ L K ++ E E L K + F + ++ +++++E
Sbjct: 836 EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAH 895
Query: 967 MRKLQKERKVFEKYTTAARTFPDKKERE--EIQTLKQ----------QIADLREDLKRKE 1014
+ + E + DK E E EIQ LK+ ++ L E L ++
Sbjct: 896 QNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEK 955
Query: 1015 TKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANT 1074
+ SS S + +I+ L +EN L+E + + +++ +++E+ + ++ E++ ++
Sbjct: 956 KEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID-EREKSISEL 1014
Query: 1075 SVRFQNSQI 1083
S +++ ++
Sbjct: 1015 SDQYKQEKL 1023
Score = 55.5 bits (132), Expect = 3e-07
Identities = 168/877 (19%), Positives = 325/877 (37%), Gaps = 155/877 (17%)
Query: 263 LFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANI 322
L+ EA + EK L+++N N + I+C E+ + ++ + D S+
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQ--KVIVCLEEELSVVTSERNQLRGELDTMSKKTTA 1976
Query: 323 EERPIKAAIGERKQTFEDYLEEQ---IQLEEQELKQKQ--LKEAEGPLPIKAKPKQPFLK 377
++ + + E+ Q E + E IQ+ E E+K+K L+ + K K +
Sbjct: 1977 LDQ-LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE 2035
Query: 378 RGEGLARFTNAKSKF---------QKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKN 428
+ + L + + A S Q KE +L+ +S S L + D ++L AL+
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095
Query: 429 KELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQ 488
+ K + R S + Q R+ + ++I+ +K ++
Sbjct: 2096 AL------VEKGEFALRLSSTQEEVHQL--------RRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 489 IKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRE---T 545
+K + + K+ V + + Q L A K+ I E +
Sbjct: 2142 LKERERENDSLKDKVENLERELQMS----EENQELVILDAENSKAEVETLKTQIEEMARS 2197
Query: 546 MKESESSLDVSLQKKLETWER---EKEKENLELDEFL------FLEQAADEISFSSNSSF 596
+K E L V+L+ + E + EK+ + ELD+ L E+ EI S
Sbjct: 2198 LKVFELDL-VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256
Query: 597 VLKILERDQQ--------ICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKE 648
+++L+ + +C + +KA Q +P H R+ AR +
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEI----MKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 649 SECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEE 708
E KQL L E ++ V+ E + ++ + +S + E
Sbjct: 2313 DE----KKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVE- 2367
Query: 709 QLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDES 768
T+K E + + E + Q+++ R +L++ + SS E+
Sbjct: 2368 ----TLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIIN---SSFEN 2420
Query: 769 IMESIKHKVSEPSRSSSLSLSKMD-------------FDDERTWTDLEENLCNHDVVLGN 815
I++ + + + SS ++ + +D+ E+NL + L
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLEL 2480
Query: 816 ESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKP 875
E N +L ++ I V+ G+ L+
Sbjct: 2481 EKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQ---------------------KLEK 2519
Query: 876 KPKSDSHLGNELKLNISQDQPPGDNARSQV-------------LREKIIELETEIEKFKA 922
K + S L N++ QDQ + SQV LR +ELE +I+ ++
Sbjct: 2520 KDEEISRLKNQI-----QDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQS 2574
Query: 923 ENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTT 982
+NASL + LE L+ + E + +E K ++M ++K K+ K T
Sbjct: 2575 KNASL-------QDTLEVLQSSYKNLENE-------LELTKMDKMSFVEKVNKMTAKETE 2620
Query: 983 AARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEI 1042
R E+ + Q+ A+L+E+L S +RL ++Q+L+ E ++++
Sbjct: 2621 LQR---------EMHEMAQKTAELQEEL-------SGEKNRLAGELQLLLEEIKSSKDQL 2664
Query: 1043 KVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQ 1079
K + + K + + +VEK+ K+ +Q
Sbjct: 2665 KELTLENSELKKSLDCMHKD-QVEKEGKVREEIAEYQ 2700
Score = 47.8 bits (112), Expect = 7e-05
Identities = 50/215 (23%), Positives = 97/215 (45%), Gaps = 34/215 (15%)
Query: 901 ARSQVLREKIIELET-----------EIEKFKAENASLAKLR---IERESALEKLRKEI- 945
A++Q LR KI ELE ++ KF+ L K + IE+E L K R E+
Sbjct: 285 AQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELV 344
Query: 946 ---ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQ 1002
A ++Q K A +++++KL ++ + +AR ++K +E+ + +++
Sbjct: 345 RTTAQYDQASTKYTA-----LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEE 399
Query: 1003 IADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESS 1062
++ + + + + +RL ++Q + L+ E+ + + + +E++
Sbjct: 400 LSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK-------QQLENN 452
Query: 1063 LEVEKKDKLANTSVRFQNSQISSG---TQVEKYKK 1094
LE E K KL FQ SQI +E+ KK
Sbjct: 453 LE-EFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Score = 43.1 bits (100), Expect = 0.002
Identities = 127/580 (21%), Positives = 226/580 (38%), Gaps = 82/580 (14%)
Query: 564 WEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQ 623
+E KEK N E++E LE + S + + + I + H+ SS+ +
Sbjct: 164 YEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIAR-HQASSSVFSWQQE 222
Query: 624 KTNPADPISHCNRSE-DLDHTAREKESECEVAPKQ-------------LHSLSSADELRE 669
KT P+ S+ R+ D +A E EV P + SS+ L +
Sbjct: 223 KT-PSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLD 281
Query: 670 QPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSRE 729
Q + ++ +E + + E + + + QL+ K ++E+ ++
Sbjct: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKA-KVELIEKEKVLNKCR 340
Query: 730 DSPQVCDDKGPFKDTRTQ----EDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSS 785
D ++ + T+ E K + + DLS + ++ ES S++ K+ E +
Sbjct: 341 D--ELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNA-ESARCSLEQKIKEKEKEFQ 397
Query: 786 LSLSKMD-----FDDE------RTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGIL 834
LS+ D E R +L++ H+V+ + + NN
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL---- 453
Query: 835 DKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKP----KPKSDSHLGNELKLN 890
+ K+K+ ++ S+ + + + E M K LK K + HL ELK N
Sbjct: 454 -EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK-N 511
Query: 891 ISQDQPPGDNARSQVLREKIIELETEI----EKFKAENASLAKLRIERESALEKLRKEIA 946
I Q N + ++ K ET + EK + SL LEKL+ +A
Sbjct: 512 IKQCLNQSQNFAEE-MKAKNTSQETMLRDLQEKINQQENSLT---------LEKLKLAVA 561
Query: 947 DFEQQK--AKELARIEEFKKEEMR-KLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQI 1003
D E+Q+ +++L + E E++ KL K K + +A KKE EE++ K
Sbjct: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALEL--KKKEYEELKEEKTLF 619
Query: 1004 ADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSL 1063
+ + + ++ T+ S L+S+I L E ++IK E +R +E
Sbjct: 620 SCWKSENEKLLTQMESEKENLQSKINHL--ETCLKTQQIKSHEYN-----ERVRTLEMDR 672
Query: 1064 EVEKKDKLANTSVRFQNSQ---ISSGTQVEKYKKNYLPMQ 1100
E N SV +N S +VE K Y+ +Q
Sbjct: 673 E--------NLSVEIRNLHNVLDSKSVEVETQKLAYMELQ 704
Score = 35.0 bits (79), Expect = 0.48
Identities = 95/524 (18%), Positives = 215/524 (41%), Gaps = 40/524 (7%)
Query: 536 LAAKSPIRETMKESESSLDVSLQKKLETWER-EKEKENLELDE---FLFLEQAADEISFS 591
+AA +E MK +E SLD ++++ + EK + LE DE L+Q + +
Sbjct: 2272 VAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 592 SNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESEC 651
++ LER+ +I + ++ + A+ + + + + + E + + R E +
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHA----ALEAENSKGEVETLKAKIEGMTQSLRGLELDV 2387
Query: 652 EVAPKQLHSLSSADELREQPCKIRKA-VQKSTSENQTEWNARDDEGVPNSDSSTDSEEQL 710
+ +L++ EL+++ +I + + S+ EN + ++ E V + S+ + E L
Sbjct: 2388 VTIRSEKENLTN--ELQKEQERISELEIINSSFENILQ--EKEQEKVQMKEKSSTAMEML 2443
Query: 711 DVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIM 770
+K E +++ + + C K ++ + + L + ++ ++
Sbjct: 2444 QTQLKELNER----VAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 771 ESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNN- 829
+S + + + L K D + R +++ +V G Q N
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQ---EQLVSKLSQVEGEHQLWKEQNL 2556
Query: 830 EIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPK---PKSDSHLGNE 886
E+ L +++KI + +S+ + T E++ + +L+ + K D E
Sbjct: 2557 ELRNLTVELEQKI-------QVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVE 2609
Query: 887 LKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIA 946
K+N + + +K EL+ E+ K A +L +E + + KE+
Sbjct: 2610 -KVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT 2668
Query: 947 --DFEQQKAKELARIEEFKKE-----EMRKLQKERKVFEKYTTAARTFPDKKEREEIQTL 999
+ E +K+ + ++ +KE E+ + Q EK A +K+ EIQT
Sbjct: 2669 LENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTY 2728
Query: 1000 KQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIK 1043
++++ E L ++ + S + ++ ++ T + EE+K
Sbjct: 2729 REKLTSKEECLSSQKLEIDLLKSS-KEELNNSLKATTQILEELK 2771
Score = 33.9 bits (76), Expect = 1.1
Identities = 30/136 (22%), Positives = 60/136 (44%), Gaps = 25/136 (18%)
Query: 918 EKFKAENASLAKLRI----------ERESALEKLRKEIADFEQQKAKELARIEEFKKEEM 967
+K+KA +KL R++ LE+L++ A Q+ +LA F +E
Sbjct: 1041 QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA----FAEERN 1096
Query: 968 RKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQ 1027
+ L E + ++ + T + E LKQ+I L+E+ ++++ +
Sbjct: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE-----------QNKMQKE 1145
Query: 1028 IQMLVRENTDLREEIK 1043
+ L++EN L + +K
Sbjct: 1146 VNDLLQENEQLMKVMK 1161
>gi|223468602 t-complex 10-like 2 [Homo sapiens]
Length = 353
Score = 58.2 bits (139), Expect = 5e-08
Identities = 49/201 (24%), Positives = 91/201 (45%), Gaps = 22/201 (10%)
Query: 978 EKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037
EK AA + E+ +L+QQI L ++L R+++ W+ H +L+S + L ++N +
Sbjct: 29 EKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRE 88
Query: 1038 LREEIKVMERFRLDAWKRAE------------AIESSL-EVEKKDKLANTSVRFQNSQIS 1084
LREE++ ++R + +A K+ A+E + ++ T+ ++ +
Sbjct: 89 LREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISPLSADEETTPKYAGRKSQ 148
Query: 1085 SGTQV-EKYKKNYL----PMQGNPPR-RSKSAPPRDLGNLDKGQAASPREPLEPLNFPDP 1138
S T + +++ N+L PM R S PP++ R P P P P
Sbjct: 149 SATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSP-APTGRPTP 207
Query: 1139 EYKEEEEDQDIQGEISHPDGK 1159
+ E +D G+I HP +
Sbjct: 208 GAERREVSED--GKIMHPSSR 226
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 58.2 bits (139), Expect = 5e-08
Identities = 204/1040 (19%), Positives = 416/1040 (40%), Gaps = 184/1040 (17%)
Query: 139 KDPLFKKLEQ--------LKEVQQKKQ---EQLKRQQ--LEQLQRLMEEQEKLLTMVSGQ 185
K+ L KKL++ LK+ Q+K++ E+LK+Q+ +LQ +EQ K + Q
Sbjct: 1173 KEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232
Query: 186 CTLPGLSLLPDDQSQKHRS-PGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNF 244
L Q Q S G + ++ C + +P + T + +SN
Sbjct: 1233 --------LRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL 1284
Query: 245 CRT--AHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKV---T 299
C +H + + + +AQ +E EK L E + T E E+V
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVEL-ELKVSSTTSELTKKSEEVFQLQ 1343
Query: 300 EQIQ----------------EANDKNLQKHDDSSE--VANIEE-RPIKAAIGE------R 334
EQI E + ++LQ+ +SS+ +A +E R ++ + E +
Sbjct: 1344 EQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
Query: 335 KQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQK 394
K+ YL Q+ +E L + Q + E IKA Q ++ E R + + +
Sbjct: 1404 KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCE 1463
Query: 395 GKES-KLVTNQSTSEDQPLFKMDRQQLQRKTALK-NKELCADNPILKKDSKARTKSGSVT 452
K+ + + +S ++ Q K+ + RK ALK NK L + + + + TKS
Sbjct: 1464 MKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS---- 1519
Query: 453 LSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFR--DQIKFENKVTSNNKENVTECPKPC 510
L+ + N++ + G ++ D D+ EN+ S++ E++ +
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE-- 1577
Query: 511 DTGCTGWNKTQGKDRL--PLSTGPASRLAAKSPIRETMKESESSLDVSLQK--------- 559
T+ K++L + + +S++A + +E KE + ++ LQ
Sbjct: 1578 -------GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Query: 560 ------------------KLETWEREKEKENLELDEFLFLEQAADEIS------FSSNSS 595
KL + E K++ +L E EQ +E+ S
Sbjct: 1631 RIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQE---AEQEMEEMKEKMRKFAKSKQQ 1687
Query: 596 FVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAP 655
+L++ E + ++ R P ++ S+ + E+L+ + E E
Sbjct: 1688 KILELEEENDRL----RAEVHPAGDTAKECMETLLSSNASMKEELERV----KMEYETLS 1739
Query: 656 KQLHSLSS-----ADELREQPCKIRKAVQKSTSENQTEWNARD----DEGVPNSDSSTDS 706
K+ SL S ++E+++ +I V K + TE + +EG + T+
Sbjct: 1740 KKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEE 1799
Query: 707 EEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSD 766
++ L ++ +P+ E S++ +P V KD+SS
Sbjct: 1800 QDSLSMSTRPTCS--ESVPSAKSANPAV-------------------------SKDFSSH 1832
Query: 767 ESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCY 826
+ I ++ R + L K + + E+N +L ST
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN-----TLLSQISTKDGELKML 1887
Query: 827 PNN--EIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLG 884
++ +L++ I+ +++ V + L ++ E +M L + +G
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTK---LKETAEEEKDDLEERLMNQLAEL------NGSIG 1938
Query: 885 NELKLNISQDQPPGDNARSQV--LREKIIELETEIEKFKAENASL-AKLRIERESALEKL 941
N + +++ Q + S++ L++ + ELE E ++ E + +++R E ++
Sbjct: 1939 NYCQ-DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGA 1997
Query: 942 RKEIADFEQQKAKELARIEEFKKEEMRKLQKE-RKVFEKYTTAART-----FPDKKEREE 995
+KE + + AKEL + + K++E+++LQK+ + EK + RT F + +++
Sbjct: 1998 QKEPGN--KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKD 2055
Query: 996 IQTLKQQIADLREDLKRKETKWSSTHSRL---RSQIQMLVRENTDLREEIKV-MERFRLD 1051
++ K+ +A E K+ + + +S L +S+ ++ +N L++E++ E +
Sbjct: 2056 LEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQ 2115
Query: 1052 AWKRAEAIESSLEVEKKDKL 1071
++ E +E LE ++ L
Sbjct: 2116 MKQKDEDLERRLEQAEEKHL 2135
Score = 50.1 bits (118), Expect = 1e-05
Identities = 176/917 (19%), Positives = 362/917 (39%), Gaps = 169/917 (18%)
Query: 297 KVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQ--------- 347
++ ++ E+ KNL+K SE+ +++ +K + ++YLE+ IQ
Sbjct: 1948 QIKNELLESEMKNLKKC--VSELEEEKQQLVKEKTKVESEIRKEYLEK-IQGAQKEPGNK 2004
Query: 348 ---LEEQEL---KQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSK----FQKGKE 397
E QEL KQ+++K+ + I+ + K L+R F +S+ K
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDC-IRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063
Query: 398 SKLVTNQSTSEDQ-PLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQK 456
++ V ++ ++ + FK+ Q + A + ADN LKK+ ++ +S + QK
Sbjct: 2064 AQAVEHRKKAQAELASFKVLLDDTQSEAA----RVLADNLKLKKELQSNKESVKSQMKQK 2119
Query: 457 P----KMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFEN-----KVTSNNKEN-VTEC 506
+ L+ + K L K +K D R+++ E +VT N K+ V +
Sbjct: 2120 DEDLERRLEQAEEKHLKE---KKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 507 PKPCDTGCTGWNKTQGKDRLPLSTGPASRLAA-KSPIRETMKESESSLDVSLQKKLETWE 565
+ D+ T +L T S L + + + K+ E ++Q K E
Sbjct: 2177 QENLDSTVT---------QLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 566 REKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKT 625
+++ ++ D+ + +E+ + + LE D+QI + + ++ T
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKIN------ISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
Query: 626 NPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSEN 685
+ ++ E+ H ++E +L SL D+L + + K ++ +
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLK--DQLTDLSNSLEKCKEQ---KG 2336
Query: 686 QTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERG--------------ISSREDS 731
E R E + +S S EQL+ ++ S E R +S +E++
Sbjct: 2337 NLEGIIRQQEA--DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEA 2394
Query: 732 PQVC-------DDKG--PFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIK----HKVS 778
QV DK ++ +QE++ V + + K +ME++K +
Sbjct: 2395 IQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQ 2454
Query: 779 EPSRSSSL--SLSKMDFDDERTWTDLEENLCNH-DVVLGNESTYGTPQTCYPNNEI---- 831
+ ++ S S+S + D +R D ++ H ++L + + NN++
Sbjct: 2455 QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLI--QEAAAENNKLKEEI 2512
Query: 832 --------GILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHL 883
+ + K ++ EDL++ + +L+ K + L
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKL 2572
Query: 884 GNELKLNISQDQPPGDNARS-QVLREKIIELETEIEKFKAENASL--------------- 927
+LK ++ D RS L+E+ +L EIE K + L
Sbjct: 2573 EEKLK---ESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGL 2629
Query: 928 --AKLRIERESA-------------LEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQK 972
A+L+++ E + +L +E+ +++ AK++ IE+ K+E++ L
Sbjct: 2630 YHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 973 ERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKW---SSTHSRLRSQIQ 1029
+ + R E +T ++++A+L DL E K + + L +QIQ
Sbjct: 2690 DAGIM---------------RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734
Query: 1030 MLVRENTDLR-------EEIKVMER-FRLDAWKRAEAIESSLEVEKKDK-LANTSVRFQN 1080
R + L+ EE+ ++R + + A+ E L ++D L+ T+ +
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS 2794
Query: 1081 SQISSGTQVEKYKKNYL 1097
++ +S + +EK + L
Sbjct: 2795 TEENSLSHLEKLNQQLL 2811
Score = 48.5 bits (114), Expect = 4e-05
Identities = 89/475 (18%), Positives = 196/475 (41%), Gaps = 83/475 (17%)
Query: 544 ETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILER 603
E +K L+++ K E +E+ +++ E+ L + + + +++S+F ER
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 604 DQQICKGHRMSS-TPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLS 662
DQ + + +S T ++A Q ++ R LD+ ++ + +Q+HSLS
Sbjct: 747 DQLLSQVKELSMVTELRA--QVKQLEMNLAEAERQRRLDYESQTAHD--NLLTEQIHSLS 802
Query: 663 SADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRE 722
E + + KI + +Q + Q +++ + S S+ Q + +R
Sbjct: 803 I--EAKSKDVKI-EVLQNELDDVQLQFSEQS-----TLIRSLQSQLQNKESEVLEGAERV 854
Query: 723 RGISSREDSPQVCDDKGPFKDTRTQE---DKRRDVDLDLSDKDYSSDESIMESIKHKVSE 779
R ISS+ + + + T+ + +K+RDV E++ ++I+ K +
Sbjct: 855 RHISSKVEELSQALSQKELEITKMDQLLLEKKRDV------------ETLQQTIEEKDQQ 902
Query: 780 PSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIK 839
+ S KM V NE + +G+ KT+K
Sbjct: 903 VTEISFSMTEKM--------------------VQLNEEKF----------SLGVEIKTLK 932
Query: 840 RKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGD 899
++ + R E+ K + + D+ + + LK N + P G
Sbjct: 933 EQLNLLSRAEEAKKE---------------------QVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 900 NARSQVLRE-KIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELAR 958
++ ++ E +++ E E K K + A + R E + +L +E+A+ + + KE+
Sbjct: 972 ISKEELQHEFDLLKKENEQRKRKLQAALIN--RKELLQRVSRLEEELANLKDESKKEIP- 1028
Query: 959 IEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRK 1013
+ E ++ E+ + ++ ++ EK T+ + ++ I + ++ +R+DL+ K
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
Score = 45.1 bits (105), Expect = 5e-04
Identities = 198/1044 (18%), Positives = 386/1044 (36%), Gaps = 194/1044 (18%)
Query: 147 EQLKEVQQKKQEQLKR--QQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRS 204
+Q ++ Q K EQ + Q ++QL+ ++++ K ++ + L Q+H +
Sbjct: 400 DQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPL-----------QQHET 448
Query: 205 PGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTS------KR 258
T+ FP VY + TQ T + ++ G +L+S K
Sbjct: 449 ASQTS--------FPD-VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499
Query: 259 ASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNL-----QKH 313
+ L S+ EA +N E +R + K + +E+ L QKH
Sbjct: 500 ENEKLSSQITLLEA---QNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKH 556
Query: 314 DDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQ 373
+ S V +E + + I K + E+ E + K+ + E EG PIK K
Sbjct: 557 KELS-VLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMK--- 612
Query: 374 PFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCA 433
FL+ G++ L+ N+ +S P + ++ + ++ +
Sbjct: 613 VFLE---------------DTGQDFPLMPNEESS--LPAVEKEQASTEHQSRTSEEISLN 655
Query: 434 DNPILKKDSKARTKSGSVTLSQKPKMLKC--SNRKSLSPSGLKIQTG-KKCDGQFRDQIK 490
D + K +K + G +LS P + +C + L L+++ K + +
Sbjct: 656 DAGVELKSTK---QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLD 712
Query: 491 FENKVTSNNKENVTECPKPCDTGCTGWNK-TQGKDRLPLSTGPASRLAAKSPIRETMKES 549
+ K SN + + E K D + + ++ +D+L L+ + +R +K+
Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQL---LSQVKELSMVTELRAQVKQL 769
Query: 550 ESSL-----------------------------------------------DVSLQ---- 558
E +L DV LQ
Sbjct: 770 EMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQ 829
Query: 559 ----KKLETWEREKEKENLE-LDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRM 613
+ L++ + KE E LE + + +E+S + S L+I + DQ + + R
Sbjct: 830 STLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS-QALSQKELEITKMDQLLLEKKRD 888
Query: 614 SSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKES---ECEVAPKQLHSLSSADELREQ 670
T + + +K IS + +E + EK S E + +QL+ LS A+E +++
Sbjct: 889 VETLQQTIEEKDQQVTEISF-SMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKE 947
Query: 671 PCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISS--- 727
+ V +N DE P S + + +K E R+R + +
Sbjct: 948 QVEEDNEVSSGLKQNY-------DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALI 1000
Query: 728 ------------REDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKH 775
E+ + D+ K+ E +R +V+ D +K+YS + +
Sbjct: 1001 NRKELLQRVSRLEEELANLKDESK--KEIPLSETERGEVEEDKENKEYSE-----KCVTS 1053
Query: 776 KVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCY-PNNEIGIL 834
K E ++S+ + + + DLEE L + QT N+I +L
Sbjct: 1054 KCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN--QTLQDKTNQIDLL 1111
Query: 835 DKTIKRKIAPVKR----------GED--LSKSRRSRSPPTSELMMKFFPSLKPK----PK 878
I A +++ G+ L K SPP + + P L+ K K
Sbjct: 1112 QAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEK 1171
Query: 879 SDSHLGNEL-------KLNISQDQPPGDNARSQVLREK--IIELETEIEKFKAENASLA- 928
L +L K + + Q + R ++ ++K L+ + ++ EN ++
Sbjct: 1172 EKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGD 1231
Query: 929 KLRIERESALEKLRKEIADFEQQKA-KELARIEE--FKKEEMRKLQK--ERKVFEKYTTA 983
+LR + E + ++ +QQ++ +EE FK E Q E + + +
Sbjct: 1232 QLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSH 1291
Query: 984 ARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLRE--- 1040
+ + + +K Q+ ++ + E K SST S L + + + + + +
Sbjct: 1292 SEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL 1351
Query: 1041 EIKVMERFRLDAWKRAEAIESSLE 1064
EI+ ++ +A AE+++ LE
Sbjct: 1352 EIESLKTVSHEAEVHAESLQQKLE 1375
Score = 43.9 bits (102), Expect = 0.001
Identities = 172/847 (20%), Positives = 319/847 (37%), Gaps = 156/847 (18%)
Query: 290 ESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLE 349
E IL EK EQ+Q+ + L + A +ER ++ E KQ +DY Q Q +
Sbjct: 1164 EKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE---ELKQQKDDYNRLQEQFD 1220
Query: 350 EQELKQKQLKEAEGPLPIKAKP----KQPFLKRGEGLARFTNAKSKFQKGKE---SKLVT 402
EQ + + + + L I+ + K P + E + + K E ++ V
Sbjct: 1221 EQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVL 1280
Query: 403 NQSTSEDQPLFKMDRQQLQRKTALKN-----KELCADNPILKKDSKARTKSGSVTLSQKP 457
+ D P D LQ T++ KE+ A+ K + + + S + L++K
Sbjct: 1281 ESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAE----KVELELKVSSTTSELTKKS 1336
Query: 458 KMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-FENKVTSN-----NKENVTECPKPCD 511
+ + ++ ++ GL+I++ K + + + K+ S+ E++ E D
Sbjct: 1337 EEV-FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 512 TGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKE 571
+K + +D LS + + AA + I+ + E E L +L +LE +E ++
Sbjct: 1396 ELQKLISKKE-EDVSYLSGQLSEKEAALTKIQTEIIEQE-DLIKALHTQLEMQAKEHDER 1453
Query: 572 NLELD-EFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADP 630
+L E ++Q +EI S + + ++R Q R +A+ + + +
Sbjct: 1454 IKQLQVELCEMKQKPEEIGEESRAK---QQIQRKLQAALISRK-----EALKENKSLQEE 1505
Query: 631 ISHCNRS-EDLDHTAREKESECEVAPKQLHS-LSSADELREQPCKIRKAVQKSTSENQTE 688
+S + E L + + ES+ K+ + L L+E+ K+ + +S ENQ
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQ-- 1563
Query: 689 WNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQE 748
S + S E L + ++ TED+E+ + E ++ +
Sbjct: 1564 -------------SLSSSCESLKLALEGLTEDKEKLVKEIESL-----KSSKIAESTEWQ 1605
Query: 749 DKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCN 808
+K +++ K+Y E +++S ++ +E R
Sbjct: 1606 EKHKEL-----QKEY---EILLQSYENVSNEAER------------------------IQ 1633
Query: 809 HDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMK 868
H V E+ Q Y G L T K K E + E M K
Sbjct: 1634 HVV----EAVRQEKQELY-----GKLRSTEANK----KETEKQLQEAEQEMEEMKEKMRK 1680
Query: 869 FFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARS--QVLREKIIELETEIEKFKAENAS 926
F S + K + L+ + P GD A+ + L ++ E+E+ K E +
Sbjct: 1681 FAKSKQQKILELEEENDRLRAEV---HPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 927 LAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYT----- 981
L+K S + L +E+ D + Q +++ + E K + V E+ T
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK--QANLEATEKHDNQTNVTEEGTQSIPG 1795
Query: 982 --------------TAARTFPDKKER------------------EEIQTLKQQIADLRED 1009
T + + P K ++I LK++IA L E+
Sbjct: 1796 ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEE 1855
Query: 1010 LKRKETKWSST----HSRLRSQIQMLVRENTDLREEIKVMERFR---LDAWKRAEAIESS 1062
K+K ++S T + L SQI E L+EE+ M + R ++ +
Sbjct: 1856 -KQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 1063 LEVEKKD 1069
E EK D
Sbjct: 1915 AEEEKDD 1921
Score = 43.9 bits (102), Expect = 0.001
Identities = 160/906 (17%), Positives = 337/906 (37%), Gaps = 129/906 (14%)
Query: 295 WEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELK 354
W++ +++Q+ + LQ +++ S A + ++A E+++ + + +E E
Sbjct: 1604 WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE-- 1661
Query: 355 QKQLKEAEGPLPIKAKPKQPFLKRGEGL------------ARFTNAKSKFQKGKESKLVT 402
KQL+EAE + + + F K + A A ++ E+ L +
Sbjct: 1662 -KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 403 NQSTSEDQPLFKMDRQQLQRK--TALKNKELCADNPILKKDSKARTKSGSVTLSQKPKML 460
N S E+ KM+ + L +K + + K+ ++ +D K + + +
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV---QDLKHQIEGNVSKQANLEATE 1777
Query: 461 KCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGW--- 517
K N+ +++ G + G+ + +D + + T + + P +
Sbjct: 1778 KHDNQTNVTEEGTQSIPGET---EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 518 --NKTQGKDRLPLS-TGPASRLAAKSPIRETMKESESSLDVSLQKK---LETWEREKEKE 571
N Q D+L G +T++ +++L + K L+ + E K
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 572 NL-------ELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQK 624
NL EL L++ A+E + ++ E + I G+ + +
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI--GNYCQDVTDAQIKNE 1952
Query: 625 TNPADP--ISHC--NRSEDLDHTAREKES-ECEVAPKQLHSLSSAD-------------E 666
++ + C E+ +EK E E+ + L + A E
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012
Query: 667 LREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGIS 726
L ++ + K +QK Q + +A + T+S++ L++T E+ + +
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEIT----KENLAQAVE 2068
Query: 727 SREDSP-QVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSS 785
R+ + ++ K DT+++ + +L L + S+ ES+ +K K + R
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128
Query: 786 LSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGI------LDKTIK 839
+ K +++ + + L V L E T G Q + + LD T+
Sbjct: 2129 QAEEK-HLKEKKNMQEKLDALRREKVHL--EETIGEIQVTLNKKDKEVQQLQENLDSTVT 2185
Query: 840 RKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGD 899
+ A K L R + KF SD+ E ++ + +D
Sbjct: 2186 QLAAFTKSMSSLQDDRDRVIDEAKKWERKF---------SDAIQSKEEEIRLKEDN---- 2232
Query: 900 NARSQVLREKIIELETEIEKFKAENASLAKLRIERESALE---KLRKEIADFEQQKAKEL 956
VL++++ ++ +E+ K + L + ES + +L++++ D Q + KEL
Sbjct: 2233 ---CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289
Query: 957 -ARIEEFK------KEEMRKLQKERKVFEKYTTAARTFPDK-------------KEREEI 996
+++EE + + E+ KL+ E K + T +K ++ +I
Sbjct: 2290 LSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI 2349
Query: 997 QTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKV-MERFRLDAWKR 1055
Q K L DL+ S H + + Q ++ + E I+V + R K
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE 2409
Query: 1056 AEAIESSLE----------------VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPM 1099
+ +E+ L V+K ++L T + I Q++ + K+ +
Sbjct: 2410 IKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSL 2469
Query: 1100 QGNPPR 1105
Q + R
Sbjct: 2470 QNDRDR 2475
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/334 (17%), Positives = 130/334 (38%), Gaps = 32/334 (9%)
Query: 750 KRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDER-------TWTDL 802
+++DV L D+ + ++ K+ +++ SL+K + + T
Sbjct: 69 RQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQS 128
Query: 803 EENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPT 862
EE L HD E EI + ++ K + + ++ P
Sbjct: 129 EEQLSKHDKSSTEEEM-----------EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQ 177
Query: 863 SELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKA 922
S M+ F +K + + + L+ +SQ Q + A QV+REK ET++ +
Sbjct: 178 SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQ--AEQAAQQVVREKDARFETQVRLHED 235
Query: 923 ENASL---AKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEK 979
E L A + E + L L++++ + E+ A++ + ++E+ ++ ++ +
Sbjct: 236 ELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR-AQVVDLLQQELTAAEQRNQILSQ 294
Query: 980 YTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLR 1039
++ E TL+ + RE+ K K + + L E L
Sbjct: 295 QL--------QQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLL 346
Query: 1040 EEIKVMERFRLDAWKRAEAIESSLEVEKKDKLAN 1073
E+ + + + + R A+E + E ++K ++
Sbjct: 347 EQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Score = 42.4 bits (98), Expect = 0.003
Identities = 176/843 (20%), Positives = 326/843 (38%), Gaps = 136/843 (16%)
Query: 345 QIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQ 404
+I++ + EL QL+ +E I++ Q K E L + K +E +Q
Sbjct: 811 KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 405 STSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSN 464
E + KMD+ L++K ++ + I +KD + S S+T KM++ +
Sbjct: 871 KELE---ITKMDQLLLEKKRDVETLQ----QTIEEKDQQVTEISFSMT----EKMVQLNE 919
Query: 465 RKSLSPSGLKIQTGK-------KCDGQFRDQIKFENKVTSNNKENVTECPKPCDTG---- 513
K G++I+T K + + ++Q++ +N+V+S K+N E
Sbjct: 920 EKF--SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 514 -----CTGWNKTQGKDRLPLSTGPASRLAAK-SPIRETMK--ESESSLDVSLQKKLETWE 565
Q K +L + L + S + E + + ES ++ L + E E
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSET-ERGE 1036
Query: 566 REKEKENLELDEFLFLEQAAD-EISFS---SNSSFVLKILERD-QQICKGHRMSSTPVKA 620
E++KEN E E + + EI S L+ + +D ++ VK
Sbjct: 1037 VEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQ 1096
Query: 621 VPQ----KTNPADP---------------ISHCNRSEDLDHTAREKESECEVAPKQLHSL 661
+ Q KTN D I+ + D D A KE+ P S
Sbjct: 1097 MNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSE 1156
Query: 662 SSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDR 721
EL E+ + K ++ + Q +R I +++
Sbjct: 1157 HWKPELEEKILALEKEKEQLQKKLQEALTSRK-------------------AILKKAQEK 1197
Query: 722 ERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKV---- 777
ER + RE+ Q DD ++ ++ K + ++ D+ + ESI K+
Sbjct: 1198 ERHL--REELKQQKDDYNRLQEQFDEQSKENE---NIGDQLRQLQIQVRESIDGKLPSTD 1252
Query: 778 SEPSRSSSLSLSKMDF---DDERTWTDLEENLC-----NHDVVLGNESTYGTPQTCYPNN 829
+ S SS+ L + F + T LE NLC + + + Q
Sbjct: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLK 1312
Query: 830 EIGILDKTIKRKIAPV-----KRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLG 884
EI ++ K++ K+ E++ + + + E+ S + + ++S
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESL-- 1370
Query: 885 NELKLNISQDQPPG-DNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRK 943
+ KL SQ Q G ++ R L+ K+ EL+ I K + + + L+ E+E+AL K++
Sbjct: 1371 -QQKLESSQLQIAGLEHLRE--LQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 944 EIADFE----------QQKAKE---------------LARIEEFKKEEMRKLQKERKVFE 978
EI + E + +AKE + EE +E K Q +RK+
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 979 KYTTAARTFPDKKE-REEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037
+ + K +EE+ + I L + L E++ S+ + + + L +
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
Query: 1038 LREEIKVMERFRLDAWKRAEAIES---SLE--VEKKDKLANTSVRFQNSQISSGTQ-VEK 1091
+ I M+R L+ + + ES +LE E K+KL ++S+I+ T+ EK
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
Query: 1092 YKK 1094
+K+
Sbjct: 1608 HKE 1610
Score = 37.4 bits (85), Expect = 0.097
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 66/382 (17%)
Query: 250 GDFV-LTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDK 308
GD+ L + S L + QEA E N LKEE R + + + + + + +
Sbjct: 2478 GDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH-----MDDLNSENAKLDAE 2532
Query: 309 NLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELK-QKQLKEAEGPLPI 367
+Q +D ++V I++ ++KQ E L++ +LE + K +++LKE+E
Sbjct: 2533 LIQYREDLNQVITIKD-------SQQKQLLEVQLQQNKELENKYAKLEEKLKESE----- 2580
Query: 368 KAKPKQPFLKRGEGLARFTNA----KSKFQKGKES-KLVTNQSTSEDQPL---------- 412
+ E L R NA K K ES K+ +Q T + L
Sbjct: 2581 ---------EANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH 2631
Query: 413 --FKMDRQQLQRKTAL---KNKELC-ADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRK 466
K+ +++ R +AL K + + ++ +A K G + K ++ +
Sbjct: 2632 AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDA 2691
Query: 467 SLSPSGLKIQTGKKCDGQF-RDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDR 525
+ + + +T ++ + RD ++ E K+ KEN G T ++ G+
Sbjct: 2692 GIMRN--ETETAEERVAELARDLVEMEQKLLMVTKEN---------KGLTAQIQSFGRS- 2739
Query: 526 LPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAA 585
+S+ SR A + E ++ ++SL Q K E +E++ L L E F +
Sbjct: 2740 --MSSLQNSRDHANEELDELKRKYDASLKELAQLK-EQGLLNRERDAL-LSETAFSMNST 2795
Query: 586 DEISFSSNSSFVLKILERDQQI 607
+E S S ++L +D+Q+
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQL 2817
Score = 37.0 bits (84), Expect = 0.13
Identities = 62/317 (19%), Positives = 130/317 (41%), Gaps = 39/317 (12%)
Query: 749 DKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMD----FDDERTWTDLEE 804
+ + + L DK + +E +E IKHK+ E S +++ ++ T++EE
Sbjct: 125 EPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEE 184
Query: 805 NLCNHDVVLGNESTYGTPQTCYPNNEI-GILDKTIKRKIA----PVKRGEDLSKSRRSRS 859
+ + E T Q + + ++ K A V+ ED +++
Sbjct: 185 FVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQA 244
Query: 860 PPTSELMMKF-FPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIE 918
+E+ K K + +S +G +++ Q + R+Q+L +++ ++E E
Sbjct: 245 DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAE-- 302
Query: 919 KFKAENASLAKLRIERESA---LEKLRKEIAD----FEQQKAKELARIEEFKKEEMRKL- 970
N + ERE + LEK+ E+A+ F + + +E+F++ +
Sbjct: 303 ----HNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAE 358
Query: 971 ---------QKERKVFEKYTTAARTFPDKKEREEIQT----LKQQIADLREDLKRKETKW 1017
QK + E+ T+ + +K +E+Q+ LK Q + L +D + +
Sbjct: 359 LESRYSALEQKHKAEMEEKTSHILSL--QKTGQELQSACDALKDQNSKLLQDKNEQAVQS 416
Query: 1018 SSTHSRLRSQIQMLVRE 1034
+ T +L Q+Q +E
Sbjct: 417 AQTIQQLEDQLQQKSKE 433
Score = 36.2 bits (82), Expect = 0.22
Identities = 159/893 (17%), Positives = 353/893 (39%), Gaps = 128/893 (14%)
Query: 263 LFSEAQYQEAPVEKNNLKEENRNHPTGESILCW-----EKVTEQIQEANDKNLQKHDDSS 317
L + Q + A V +NLK + ES+ E + ++++A +K+L+
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLK------ 2136
Query: 318 EVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLK 377
E N++E+ + A E+ E E Q+ L +++ + +QL+E +
Sbjct: 2137 EKKNMQEK-LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ--------- 2186
Query: 378 RGEGLARFTNAKSKFQKGK----------ESKLVTNQSTSEDQPLFKMD-----RQQLQR 422
LA FT + S Q + E K + E++ K D + QL R
Sbjct: 2187 ----LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL-R 2241
Query: 423 KTALKNKELCADNPILKKD-----SKARTKSGSVTLSQKP-KMLKCSNRKSLSPSGLKIQ 476
+ ++ +EL + L+ D SKA+T+ V L QK L+ N++ LS +
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWESKAQTE---VQLQQKVCDTLQGENKELLSQLE---E 2295
Query: 477 TGKKCDGQFRDQIKFENKVTS-----NNKENVTECPKPCDTGCTGWNKTQGKD------- 524
T + K E+++ S + N E K G + Q D
Sbjct: 2296 TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 525 --RLPLSTGPASRLAAKSPIRETMKESE-----SSLDVSLQKKLETWEREKEKENLELDE 577
+L + L ++ MKE + S + ++Q + ++ +KE EL+
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 578 FLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPI-SHCNR 636
L E+ + + N K +++ Q+ + + + + + QK + S +
Sbjct: 2416 LLSQEEEENIVLEEENK----KAVDKTNQLME--TLKTIKKENIQQKAQLDSFVKSMSSL 2469
Query: 637 SEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEG 696
D D + + ++ + L + D+L +Q++ +EN + G
Sbjct: 2470 QNDRDRIVGDYQ---QLEERHLSIILEKDQL----------IQEAAAENNKL--KEEIRG 2514
Query: 697 VPNSDSSTDSEE-QLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVD 755
+ + +SE +LD + ED + I+ + DS Q + + + E+K ++
Sbjct: 2515 LRSHMDDLNSENAKLDAELIQYREDLNQVITIK-DSQQKQLLEVQLQQNKELENKYAKLE 2573
Query: 756 LDLSDKDYSSDE-----SIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEEN----L 806
L + + ++++ + ++ K +S+ S +S+S++ R T L+E L
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLT----RQVTALQEEGTLGL 2629
Query: 807 CNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELM 866
+ + + E + + L + +++IA ++ E+L ++ + E+
Sbjct: 2630 YHAQLKVKEEEVH----------RLSALFSSSQKRIAELE--EELVCVQKEAAKKVGEIE 2677
Query: 867 MKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQV-LREKIIELETEIEKFKAENA 925
K LK + NE + + ++ + AR V + +K++ + E + A+
Sbjct: 2678 DKLKKELKHLHHDAGIMRNETE---TAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ 2734
Query: 926 SLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAAR 985
S + +++ + +E+ + +++ L + + K++ + L +ER T +
Sbjct: 2735 SFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGL--LNRERDALLSETAFSM 2792
Query: 986 TFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVM 1045
++ ++ L QQ+ E L ++ ++++++S + + + +
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852
Query: 1046 ERFR-LDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYL 1097
E+FR + K+ A + S + L QN + +++ ++ YL
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYL 2905
Score = 35.4 bits (80), Expect = 0.37
Identities = 42/179 (23%), Positives = 82/179 (45%), Gaps = 33/179 (18%)
Query: 912 ELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQ 971
EL++ + K +N+ L + + E+ + +++ D QQK+KE+++
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQF------------ 437
Query: 972 KERKVFEKYTTAART-FPD-------KKEREEIQTLKQQIADLRED--------LKRKET 1015
R +++ TA++T FPD E I +L++++ +L + ++ +E
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 1016 KWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANT 1074
K + + +L SQI +L +N + +V E +D A SS E +D L NT
Sbjct: 498 K--AENEKLSSQITLLEAQNRTGEADREVSEISIVDI---ANKRSSSAEESGQDVLENT 551
Score = 32.3 bits (72), Expect = 3.1
Identities = 50/244 (20%), Positives = 100/244 (40%), Gaps = 34/244 (13%)
Query: 881 SHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEK 940
S L N + +S D N R+ + E E + E E+ ER + E+
Sbjct: 6 SGLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTTQEDVQ------ERLAYAEQ 59
Query: 941 LRKEIADFEQQKAKELARIEEFKKEEMR---------------KLQKERKVFEKYTTAAR 985
L E+ D +QK +L + +E +EE + KL K E+
Sbjct: 60 LVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGG 119
Query: 986 TFPDKKEREEIQTLK---------QQIADLREDLKRKETKWSSTHSRL-RSQIQMLVREN 1035
T + + E Q K +I ++ L+ KE S+ ++L ++Q + + +
Sbjct: 120 TVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSS 179
Query: 1036 TDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKN 1095
T++ EE +M++ + + +++ L + ++ A VR ++++ TQV ++
Sbjct: 180 TEM-EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFE--TQVRLHEDE 236
Query: 1096 YLPM 1099
L +
Sbjct: 237 LLQL 240
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/397 (19%), Positives = 174/397 (43%), Gaps = 46/397 (11%)
Query: 716 PSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIME--SI 773
P + E +S ED Q K ++ R +R + ++ + ++ D+ + E S+
Sbjct: 1316 PEHHNLENEVSRLEDIMQHLKSKK--REERWMRASKRQSEKEMEELHHNIDDLLQEKKSL 1373
Query: 774 KHKVSEPSRSSSLSLSKMDFDDER-----TWTDLEENLCNHDVVLGNESTYGTPQTCYPN 828
+ +V E R+ + DF D T ++E++L +H+ ++
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIV--------------- 1418
Query: 829 NEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELK 888
+EI ++KT+ +KR +L ++ R + SEL K K K+ + K
Sbjct: 1419 DEIECIEKTL------LKRRSELREADRLLAEAESELSCT-----KEKTKNAVEKFTDAK 1467
Query: 889 LNISQDQPPGDNA--RSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIA 946
++ Q + + R+Q +++ + ++ +A+ L + +I++E L+++ K +A
Sbjct: 1468 RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
Query: 947 DFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKE------REEIQTLK 1000
+ + L++ +E EE++KLQK+ ++ E+ + E R E++ LK
Sbjct: 1528 A-KDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 1586
Query: 1001 QQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIE 1060
Q+ ++++ + + L +V+ DL+E +++ E + ++
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVK 1646
Query: 1061 SSLEVEKKDK-LANTSVRFQNSQISSGTQ-VEKYKKN 1095
S LE K N + + +Q++ Q +EK ++N
Sbjct: 1647 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEEN 1683
Score = 48.5 bits (114), Expect = 4e-05
Identities = 159/813 (19%), Positives = 316/813 (38%), Gaps = 142/813 (17%)
Query: 296 EKVTEQIQEAN-DKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQEL- 353
EK+TE++Q+ D + + ++ + ++E + + + K+ + L+ Q+ ++QE+
Sbjct: 1541 EKLTEELQKLQKDIEMAERNEDHHLQVLKESEV---LLQAKRAELEKLKSQVTSQQQEMA 1597
Query: 354 --------KQKQLKEAEGPLPIKAKPKQPFLKRGEGLA-----RFTNAKSKFQKGKESKL 400
K+++L +G + Q L+ GE KS ++ K
Sbjct: 1598 VLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKG 1657
Query: 401 VTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKML 460
N SE + + +Q+++++ +N ++ +L++ SK +T+ ++ ML
Sbjct: 1658 ELNVQISERKTQLTLIKQEIEKEE--ENLQV-----VLRQMSKHKTELKNIL-----DML 1705
Query: 461 KCSNRKSLSPSGLKIQTGKKCDGQFRDQIK-FENKVTSNNKENVTECPKPCDTGCTGWNK 519
+ N + GLK+Q ++ + Q+ E K+ N + +++ K G W K
Sbjct: 1706 QLENHEL---QGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQK----GEIEWQK 1758
Query: 520 TQ-GKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEF 578
+D+ + A A +S + KE E LQ+K + WE++ + L
Sbjct: 1759 QLLERDKREIERMTAESRALQSCVECLSKEKED-----LQEKCDIWEKKLAQTKRVL--- 1810
Query: 579 LFLEQAADEISFSSNSSF------VLKILERDQQICKGHRMSSTPVKAVPQKTNPADPIS 632
AA+E S S+ V K+ + Q+ + + A+ Q+
Sbjct: 1811 ----AAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAV 1866
Query: 633 HCNRSE---DLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEW 689
+ + E DH K+ LH+ D L + +++K + +EW
Sbjct: 1867 NSLQEELANVQDHLNLAKQD-------LLHTTKHQDVLLSEQTRLQKDI--------SEW 1911
Query: 690 NARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQED 749
R ++ ++ ++QL V ++ E+ + + +E Q K+ ++E
Sbjct: 1912 ANRFEDCQKEEET---KQQQLQV-LQNEIEENKLKLVQQEMMFQRLQ-----KERESEES 1962
Query: 750 KRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWT-DLEENLCN 808
K + L ++ + ++ + + K K+ + LSK+ +ER T EE C
Sbjct: 1963 KLETSKVTLKEQQHQLEKELTDQ-KSKLDQ-------VLSKVLAAEERVRTLQEEERWCE 2014
Query: 809 HDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGE--DLSKSRRSRSPPTSELM 866
E T + E +++K+ GE L K S S L
Sbjct: 2015 -----SLEKTLSQTKRQLSEREQQLVEKS----------GELLALQKEADSMRADFSLLR 2059
Query: 867 MKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENAS 926
+F K K + L LK+ SQ L + ++E + E + E A+
Sbjct: 2060 NQFLTERKKAEKQVASLKEALKIQRSQ------------LEKNLLEQKQENSCIQKEMAT 2107
Query: 927 LAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAART 986
+ + + +L KE+ + + E KK+ + ER+ E + A RT
Sbjct: 2108 IELVAQDNHERARRLMKELNQMQYE-------YTELKKQMANQKDLERRQME-ISDAMRT 2159
Query: 987 FPDKKEREEIQT--------LKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDL 1038
+ ++EI+T L + ADL L+R E S L+ + + E
Sbjct: 2160 L-KSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELES-LKENLPFTMNEG-PF 2216
Query: 1039 REEIKVMERFRLDAWKRAEAIESSLEVEKKDKL 1071
E++ + +D R EA+ L ++D+L
Sbjct: 2217 EEKLNFSQVHIMDEHWRGEALREKLR-HREDRL 2248
Score = 42.0 bits (97), Expect = 0.004
Identities = 104/529 (19%), Positives = 201/529 (37%), Gaps = 69/529 (13%)
Query: 584 AADEISFSSNSSFVLKILERDQQI------CKGHRMSSTPVKAVPQKTNPADPISHCNRS 637
A + S + +K +E D+Q+ +GH T ++ +K + A R
Sbjct: 399 ATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ-----TRL 453
Query: 638 EDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGV 697
+L + E + A ++ L A +L++ + + K S N E +
Sbjct: 454 SELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEAL 513
Query: 698 PNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLD 757
D E+Q K +++ I + + D K P + ++ LD
Sbjct: 514 ---DLELQMEKQ-----KQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLD 565
Query: 758 LSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLC----NHDVVL 813
+ +K Y ES ++ I ++++ + D +++ T + N V+
Sbjct: 566 IMNKQYQQLESRLDEILSRIAKETEEIK------DLEEQLTEGQIAANEALKKDLEGVIS 619
Query: 814 GNESTYGT--PQTCYPNNEIGIL---DKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMK 868
G + GT Q NE L +T+ +++ V++ D + +E M K
Sbjct: 620 GLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERD----QLEIVAMDAENMRK 675
Query: 869 FFPSLKPKPKSDSHLGNELKLNISQDQPPGD-NARSQVLREKIIELETEIEKFKAENASL 927
L +S L + ++N S Q GD +A L ++ + E + K E +
Sbjct: 676 ELAEL------ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729
Query: 928 AKLRIERESALE-KLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAART 986
+L +SAL+ +L KE + K A+ E K++E +L + K +
Sbjct: 730 TRLTQLEQSALQAELEKERQALKNALGK--AQFSEEKEQENSELHAKLKHLQDDNNLL-- 785
Query: 987 FPDKKEREEIQTLKQQIAD---------LREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037
K++ ++ Q + D R D R++ K + + S +L + D
Sbjct: 786 ---KQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLAD 842
Query: 1038 LREEIKVMERFRLDAWKRAEA--IESSLEVE---KKDKLANTSVRFQNS 1081
L+++ E W+R EA E L+ E +++KLA F+ +
Sbjct: 843 LQKQFS--EILARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQA 889
Score = 40.0 bits (92), Expect = 0.015
Identities = 45/205 (21%), Positives = 94/205 (45%), Gaps = 34/205 (16%)
Query: 906 LREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKE 965
LR++ ++LE ++EK K E A K + + A++ L + KA++ + ++
Sbjct: 508 LRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIM 567
Query: 966 EMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD--------LREDL------- 1010
+ Q E ++ E + A KE EEI+ L++Q+ + L++DL
Sbjct: 568 NKQYQQLESRLDEILSRIA------KETEEIKDLEEQLTEGQIAANEALKKDLEGVISGL 621
Query: 1011 -------KRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDA---WKRAEAIE 1060
K + T+ + +LR + + L++ T++ +E +E +DA K +E
Sbjct: 622 QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
Query: 1061 SSLEVEKKDKLANTSVRFQNSQISS 1085
S+L+ + + N S++ +S+
Sbjct: 682 SALQEQHE---VNASLQQTQGDLSA 703
Score = 38.5 bits (88), Expect = 0.044
Identities = 44/188 (23%), Positives = 77/188 (40%), Gaps = 22/188 (11%)
Query: 903 SQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEF 962
S VL + + +L+ + + LA+ + ER+ A + RK + Q+ K EEF
Sbjct: 833 SDVLGKSLADLQKQFSEI------LARSKWERDEAQVRERKLQEEMALQQEKLATGQEEF 886
Query: 963 KKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHS 1022
R+ E+ A F ++ IQ ++ +I L+E+LK E T
Sbjct: 887 -----------RQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDL 935
Query: 1023 RLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKK-----DKLANTSVR 1077
+L+ + R LRE K + + ++ ++ L+ KK DKLA +
Sbjct: 936 QLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELT 995
Query: 1078 FQNSQISS 1085
Q+ S
Sbjct: 996 IAKDQLKS 1003
Score = 33.1 bits (74), Expect = 1.8
Identities = 50/214 (23%), Positives = 91/214 (42%), Gaps = 45/214 (21%)
Query: 904 QVLREKIIELETEIEKFKAENASLAKLRIERESALE-----------KLRKEIADFEQQK 952
QVL+ +I E + ++ + + L K R ES LE +L KE+ D + +
Sbjct: 1930 QVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKL 1989
Query: 953 AKELARIEEFKKEEMRKLQKERKVFEKY-TTAARTFPDKKERE--------EIQTLKQQI 1003
+ L+++ +E +R LQ+E + E T ++T ERE E+ L+++
Sbjct: 1990 DQVLSKVLA-AEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEA 2048
Query: 1004 ADLREDL-----------KRKETKWSSTHSRLRSQIQMLVR-------ENTDLREEIKVM 1045
+R D K+ E + +S L+ Q L + EN+ +++E+ +
Sbjct: 2049 DSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATI 2108
Query: 1046 ERFRLDAWKRAEAIESSLE------VEKKDKLAN 1073
E D +RA + L E K ++AN
Sbjct: 2109 ELVAQDNHERARRLMKELNQMQYEYTELKKQMAN 2142
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 57.4 bits (137), Expect = 9e-08
Identities = 185/1071 (17%), Positives = 424/1071 (39%), Gaps = 133/1071 (12%)
Query: 126 IPDLASEF-KEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLT--MV 182
I D+ S++ +E + ++ +K+ +L E K+ ++ + E LQR E +L +V
Sbjct: 172 IADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELV 231
Query: 183 SGQCTLPGLSLLPDDQSQKHRSP-----GNTTTGERATCCFPSYVYPDPTQEETYPSNIL 237
Q + ++L + +S+K + + E S + P + Y +
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ 291
Query: 238 SHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNN---LKEENRNHPTGESILC 294
+++ + ++ + NL + Q EK+N + ++N + L
Sbjct: 292 K------LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 345
Query: 295 WEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELK 354
+++ ++ + + H + SE ++ +K + E + ++ E QL++Q
Sbjct: 346 CQQLQSRLSASETSLHRIHVELSEKGEATQK-LKEELSEVETKYQHLKAEFKQLQQQ--- 401
Query: 355 QKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNAKSKFQKGKE---SKLVTNQSTSEDQP 411
++ KE G L ++++ Q K E + A + ++ ++ KL+ + D
Sbjct: 402 -REEKEQHG-LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 412 LFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPS 471
L K+ R + Q K + N L K + + ++ S K+ + N
Sbjct: 460 L-KLSRLEEQLKEKVTNSTELQHQ--LDKTKQQHQEQQALQQSTTAKLREAQN------- 509
Query: 472 GLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTG 531
++ + G +I+ + +KEN++ K + +G+ T
Sbjct: 510 --DLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE------TA 561
Query: 532 PASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLEL-----------DEFLF 580
++L K+ T++E + L L+ + E+ ++ +E + ++ D L
Sbjct: 562 VLNQLQEKN---HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 581 LEQAADEISFSSNSSFVLKILERDQQI-CKGHRMSSTPVKAVPQKTNPADPISHCNRSED 639
LE + +E++ N S K+ + D QI K + S Q+ AD +H + +++
Sbjct: 619 LETSVNELNSQLNESKE-KVSQLDIQIKAKTELLLSAEAAKTAQR---ADLQNHLDTAQN 674
Query: 640 LDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPN 699
++K+ E QL +++ + +++ C ++ K E + +E
Sbjct: 675 ---ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE---- 727
Query: 700 SDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLS 759
+ E + +K S +E+ + + Q+ D + T+ K+ +++ ++
Sbjct: 728 LEGQIKKLEADSLEVKAS---KEQALQDLQQQRQLNTD---LELRATELSKQLEMEKEIV 781
Query: 760 DK---DYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNE 816
D +ESIK K+++ + K DF+ T ++ N+ + +
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQIL--KQDFETLSQETKIQHEELNNRI----Q 835
Query: 817 STYGTPQTCYPNNEIGILD-KTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKP 875
+T Q E + + T+K K++ V SKS + + ++
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA------AILD 889
Query: 876 KPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIE-KFKAENASLAKLRIER 934
K+ L ++L++ + + + Q +K +E E E + K E S+ + I+
Sbjct: 890 LEKTCKELKHQLQVQME------NTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
Query: 935 ESALEKLRKE----------IADFEQQKAKELARIE-EFKKEEMRKLQKERKVFEKYTTA 983
++ L++ KE + +QK K++ ++ E K ++K + E K+ ++ T A
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQA 1003
Query: 984 ARTFPDKKEREEI---------QTLKQQIADL----------REDLKRKETKWSSTHSRL 1024
A+ +KE+ + +T KQ +D R+DLK E K S L
Sbjct: 1004 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL 1063
Query: 1025 RSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSL----EVEKKDKLANTSVRFQN 1080
S + +N ++E D+ K+ + ++ +++K+ L + +
Sbjct: 1064 ISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEK 1123
Query: 1081 SQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLE 1131
S+++ +++ ++ + + K +++ NL + ++ LE
Sbjct: 1124 SKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Score = 48.5 bits (114), Expect = 4e-05
Identities = 229/1158 (19%), Positives = 452/1158 (39%), Gaps = 183/1158 (15%)
Query: 118 QEENKN-DFIPDLASEFKEGAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQE 176
+E NK I DL +E + + + ++L +VQ ++ E ++L +E +
Sbjct: 198 EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES-EKLKDECK 256
Query: 177 KLLTM-VSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSN 235
KL + S + T+ L +S+ + P + S V + +T N
Sbjct: 257 KLQSQYASSEATISQL------RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 236 ILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCW 295
+L EQ D+ ++ + S+ Q A + + +L + S
Sbjct: 311 LLKKEQ---------DYTKLEEKHNEESVSKKNIQ-ATLHQKDLDCQQLQSRLSASETSL 360
Query: 296 EKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELK- 354
++ ++ E + + ++ SEV + + +KA + +Q E+ + +QL+ + +
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVET-KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 355 -------QKQLKEAEGPLPIKAK-PKQPFLKRGEGLARFTNAKSKFQKGKESKLVTNQST 406
++QL EA G L + + + + + + +A S+ ++ + K VTN ST
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK-VTN-ST 477
Query: 407 SEDQPLFK-----MDRQQLQRKTALKNKELCAD-----NPILKKDSKARTKSGSVTLSQK 456
L K ++Q LQ+ T K +E D I KD K + + S++
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 457 PKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTG 516
L R+ L KIQ G+ + +Q++ +N +E VT+ +
Sbjct: 538 NISLLEKEREDLYA---KIQAGEG-ETAVLNQLQEKNHTL---QEQVTQLTEKLKNQSES 590
Query: 517 WNKTQGKDRLPLSTGPASRLAAKSPI---RETMKESESSLDVSLQKKLETWEREKEKENL 573
+ Q + A AA+ + ++ E S L+ S +K + + K K L
Sbjct: 591 HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL 650
Query: 574 ELD-EFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPIS 632
L E Q AD + + L+ ++ Q++ K +T + V K D
Sbjct: 651 LLSAEAAKTAQRADLQNHLDTAQNALQ--DKQQELNK----ITTQLDQVTAKLQ--DKQE 702
Query: 633 HCNRSEDLDHTAREK----ESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQT- 687
HC++ E +EK E + E Q+ L AD L + K +A+Q + Q
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE-ADSLEVKASK-EQALQDLQQQRQLN 760
Query: 688 ---EWNARDDEGVPNSDSSTDSEEQLDVTIKPST-EDRERGISSREDSPQVC--DDKGPF 741
E A + + S +LD+ K E ++ ++ +E+ Q+ D +
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 742 KDTRTQEDK---RRDVDLDLSDKDYSSDESIM---ESIKHKVSEPSRSSSLSLSKMDFDD 795
++T+ Q ++ R + K E++M ++K K+S+ S SL SK +F+
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS--DSLKNSKSEFEK 878
Query: 796 ER-----TWTDLEENL--CNHDVVLGNESTYGTPQTCYPNNE-----IGILDKTIKRKIA 843
E DLE+ H + + E+T + + E L +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 844 PVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARS 903
+ + ++ K + + S + K K L ELK+ + Q + +
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 998
Query: 904 QVL---------REKIIELETEIEK-----------FKAENASLAKLRIERESALEKL-- 941
Q+ +EKI L+ EK F + L R + +S EKL
Sbjct: 999 QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1058
Query: 942 --------RKEI--------------ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEK 979
R +I A EQ AK+ +++E + + ++ +QKE+ + EK
Sbjct: 1059 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE-RCKALQDIQKEKSLKEK 1117
Query: 980 YTTAARTFPDKKEREEIQTLK----QQIADLREDLKRKETKWSSTHSRLRSQIQMLVREN 1035
+K + EI+ +K ++I L E+LK + + ++E
Sbjct: 1118 -----ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLE--------------SIKEI 1158
Query: 1036 TDLREEIKVMERFRLDAWKRAEAIESSLEVEK------KDKLANTSVRFQNSQISSGTQV 1089
T+L++ +++ + +L+ +A+++++++E EK KD++ + I ++
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKL 1218
Query: 1090 -EKYKKNYLPMQGNPPRRSK-----SAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKEE 1143
+ K+ + M+ + +K +A +LG + K +S R E E
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE----------LE 1268
Query: 1144 EEDQDIQGEISHPDGKVE 1161
++ D++GEI+ + V+
Sbjct: 1269 KQTDDLRGEIAVLEATVQ 1286
Score = 38.5 bits (88), Expect = 0.044
Identities = 38/178 (21%), Positives = 89/178 (50%), Gaps = 21/178 (11%)
Query: 913 LETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMR---K 969
LE ++E+ + EN ++ +++ E +L EIAD + + +E + E +++ R +
Sbjct: 140 LEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEE 199
Query: 970 LQKERKVFEKYTTAARTFPD-------KKEREEIQTL--------KQQIADLREDLKRKE 1014
L KE V + T P KKE ++QTL +++ L+++ K+ +
Sbjct: 200 LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQ 259
Query: 1015 TKWSS---THSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKD 1069
++++S T S+LRS++ +E +E++ ++ + ++ + + +L +++D
Sbjct: 260 SQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 57.4 bits (137), Expect = 9e-08
Identities = 112/523 (21%), Positives = 205/523 (39%), Gaps = 90/523 (17%)
Query: 300 EQIQEANDKNLQKHDDSS----EVANIEE-RPIKAAIGERKQTF-------------EDY 341
E++ DK ++ S EV + EE P+KA + E++ T E
Sbjct: 584 EKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETK 643
Query: 342 LEEQIQLEEQELKQKQLKEAEGPLPIK--AKPKQPFLKRGEGLARFTNAKSKFQKGKESK 399
++ + + EE+E +K++ + E PIK KPK+ +K+ K + +K +E K
Sbjct: 644 VKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKK--------EVKKEIKK-EEKK 694
Query: 400 LVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKM 459
+ E P + + K +K +E I K A+ S ++ ++KP
Sbjct: 695 EPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAA 754
Query: 460 LKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKEN--VTECPKPCDTGCTGW 517
LK P K + K D + K + K+ KE TG T
Sbjct: 755 LK--------PKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGAT-- 804
Query: 518 NKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKE-NLELD 576
+ A+ +AA P +E E+E SL S + + +E K +E ++ D
Sbjct: 805 ---------TAAVMAAAGIAAIGPAKEL--EAERSLMSSPEDLTKDFEELKAEEVDVTKD 853
Query: 577 EFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNR 636
LE DE ++++++++ KG PA+
Sbjct: 854 IKPQLELIEDEEKLKETEPVEAYVIQKEREVTKG----------------PAE------- 890
Query: 637 SEDLDHTAREKESECEVAPKQLHSL--SSADELREQPCKIRKAVQKSTSENQTEWNARDD 694
S D T E E ECE P++L + D++ + + ++S+ E A +
Sbjct: 891 SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDE-GAGFEESSETGDYEEKAETE 949
Query: 695 EGVPNSDSSTDSEEQLDVTIK--PSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR 752
E + D EE + V+ TED E S++ ++ +K +++ D R
Sbjct: 950 EA---EEPEEDGEEHVCVSASKHSPTEDEE---SAKAEADAYIREK---RESVASGDDRA 1000
Query: 753 DVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDD 795
+ D+D + + +++S E+ + +E +R KM+ +D
Sbjct: 1001 EEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAED 1043
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/184 (25%), Positives = 87/184 (47%), Gaps = 19/184 (10%)
Query: 850 DLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREK 909
+++K PP E K K D + E K ++++ + P S V E
Sbjct: 567 EVTKVNHVEKPPKVESKEKVMV------KKDKPIKTETKPSVTEKEVPSKEEPSPVKAEV 620
Query: 910 IIELETEIEKFKAENASLAKLRI----ERESALEKLRKEIADFEQQ---KAKELARIEEF 962
+ T+++ A+ ++ K +++ EK +KE+A E + K +E + EE
Sbjct: 621 AEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEV 680
Query: 963 KKEEMRKLQKERKVFEKYTTAARTFPD--KKE--REEIQTLKQQIADLREDLKR--KETK 1016
KKE ++++KE K K T P KKE +EE + +K++ + ++++K+ K+ K
Sbjct: 681 KKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAK 740
Query: 1017 WSST 1020
SST
Sbjct: 741 KSST 744
>gi|21389535 T-complex 10A-2 [Homo sapiens]
Length = 215
Score = 57.0 bits (136), Expect = 1e-07
Identities = 41/145 (28%), Positives = 71/145 (48%), Gaps = 8/145 (5%)
Query: 976 VFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVREN 1035
V EK AA + E+ L+QQI L ++L R+++ W+ H +LRS I L +N
Sbjct: 27 VMEKTAVAAEVLTEDCNTGEMPPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQN 86
Query: 1036 TDLREEIKVMERFRLDAWK-RAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQ-VEKY- 1092
+LRE+++ ++ L WK R ++ S ++ LA + S +S+ + + KY
Sbjct: 87 MELREKLRALQ---LQRWKARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYA 143
Query: 1093 --KKNYLPMQGNPPRRSKSAPPRDL 1115
K + G + SAPP+ +
Sbjct: 144 GHKNQSATLLGQRSSSNNSAPPKPM 168
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A member
6-like protein 6 [Homo sapiens]
Length = 655
Score = 56.6 bits (135), Expect = 2e-07
Identities = 100/509 (19%), Positives = 212/509 (41%), Gaps = 54/509 (10%)
Query: 681 STSENQTEWNARDDEGVPNSDSSTDS-----EEQLDVTIKPSTEDRERGISSREDSPQVC 735
S N ++++ + + DS D E+Q V K + RE+ I+ E Q+
Sbjct: 9 SERANSSKFDPTKSPVLSDEDSDLDFHINKLEQQSKVRNKGHGKPREKSIAD-EKFFQLS 67
Query: 736 DDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKV-----SEPSRSSSLSLSK 790
+ + ++ + + KR D D DL + + S + ES+K E + +S K
Sbjct: 68 EMEAYLENRKRRGTKRWDEDDDLEESEDS--KQCKESLKRVTFTLPDDEAIEDAGVSHVK 125
Query: 791 MDFDDERTWTDLEENLCNHD-------VVLGNESTYGTPQTCYPNNEIGILDKTIKRKIA 843
+ D+ ++ + N VV+ T E +L++T+ A
Sbjct: 126 KNSDEVKSSFKKRQEKMNEKNYTFRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDHA 185
Query: 844 PVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARS 903
V+ G + K + R P+ EL + K K+ + L +L+L S+ N +
Sbjct: 186 -VRMGTYIEKLTKERDAPSLELYRNTITDEELKEKN-AELQEKLRLVESEKSEIQLNVKD 243
Query: 904 QVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFE-------QQKAKEL 956
+ + +L ++ + E L K E +S KL+ ++ + E QQ+ K
Sbjct: 244 LKRKLERAQLLLPQQQLQVEADRLGK---ELQSVSAKLQAQVEENELWNLLNQQQEEKMW 300
Query: 957 ARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETK 1016
+ E+ +++E + ++E K+ E+ R + E++ +++I + + + R+E K
Sbjct: 301 RQEEKIQEQEEKMCEQELKIREQEEKMWR------QEEKMHEQEEKIREQEDKMWRQEEK 354
Query: 1017 WSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSV 1076
++R Q + + R+ +RE+ + ++ + W++ E I E ++++K+
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ-EEKRQEKMWRQEK 413
Query: 1077 RFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFP 1136
+ + Q EK ++ M + R+L + + Q RE E +
Sbjct: 414 KMRE-------QDEKIREQEEEMW------RQEEKIRELEEMMQDQEEKLREVEEKMQ-- 458
Query: 1137 DPEYKEEEEDQDIQGEISHPDGKVEKVYK 1165
+ E K +E+++ IQ + + EK ++
Sbjct: 459 EEEEKMQEQEEKIQRQEEKIQEQEEKTWR 487
Score = 46.2 bits (108), Expect = 2e-04
Identities = 57/293 (19%), Positives = 133/293 (45%), Gaps = 21/293 (7%)
Query: 874 KPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAEN-ASLAKLRI 932
K + + D E K+ +++ + EKI E + +I++ + E K+R
Sbjct: 340 KIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIRE 399
Query: 933 ERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKE 992
+ E EK+ ++ E++ ++ +I E ++E R+ +K R++ E + +
Sbjct: 400 QEEKRQEKMWRQ----EKKMREQDEKIREQEEEMWRQEEKIRELEEMM---------QDQ 446
Query: 993 REEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDA 1052
E+++ +++++ + E ++ +E K +++ Q + R+ L++E K+ E+
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQ-EEKM 505
Query: 1053 WKRAEAIESSLE--VEKKDKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSA 1110
W++ E + E E+++K+ + + ++ Q EK ++ + +Q R K
Sbjct: 506 WRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565
Query: 1111 PPRDLGNLDKGQAASPREP-LEPLNFPDPEYKEEEEDQDIQGEISHPDGKVEK 1162
+L ++ S R P L P+ E K +E Q +Q + H G +++
Sbjct: 566 QKAELLGGAGRESGSQRLPTLTPI--LQVELKSQEA-QSLQQQQDHYRGHLQQ 615
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 56.2 bits (134), Expect = 2e-07
Identities = 126/613 (20%), Positives = 252/613 (41%), Gaps = 71/613 (11%)
Query: 536 LAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSS 595
L AK TM E+ V L +LE +R+ E ++E + + E++ S S
Sbjct: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEES-ITKGDLEVATVSEKS 464
Query: 596 FVLKILERD-----QQICKGHRM--SSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKE 648
+++ LE+D Q++ + R S+ P V + IS ++ T ++E
Sbjct: 465 RIME-LEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 523
Query: 649 SECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEE 708
+ + H + + +++ + A +K + EN++ + + NSD +
Sbjct: 524 ----ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKS 579
Query: 709 QLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRR-DVDLDLS------DK 761
+L+ I + E S S + + F + +TQ +K R D ++ D
Sbjct: 580 KLETAIASHQQAMEELKVSF--SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDS 637
Query: 762 DYSSDESIMESIKHKVSEPSRSSSLSL----SKMDFDDERTWTDLEENLCN-HDVVLGNE 816
+ ++ ME+++ K+ + + SL SK+D +++ ++E+ L + + +
Sbjct: 638 ERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
Query: 817 STYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPK 876
C N + ++D + A ++ DL R++ S SE M K L+
Sbjct: 698 ELEVLQAKC--NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE-MKKLRQQLEAA 754
Query: 877 PKSDSHL-------------------GNELKL-----NISQDQPPGDNARS--QVLREKI 910
K HL G ELKL N+S+ + Q+L+EK
Sbjct: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814
Query: 911 IELETE-IEKFKAENASLAKLRIERE------SALEKLRKEIADFEQQKAKELARIEEFK 963
E E + ++ ++ KL + E S LEKLR+ +AD E + ++ R E+
Sbjct: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
Query: 964 KEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSR 1023
K + KL+ + K + + K +E++ ++ + E+L+ K TK + S
Sbjct: 875 KAK-EKLENDIAEIMK-MSGDNSSQLTKMNDELRLKERDV----EELQLKLTKANENASF 928
Query: 1024 LRSQIQ-MLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQ 1082
L+ I+ M V+ +E K E + + ++ +E +E ++ R++ +
Sbjct: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET-SHNQCQELKARYERAT 987
Query: 1083 ISSGTQVEKYKKN 1095
+ T+ E+ +N
Sbjct: 988 SETKTKHEEILQN 1000
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 56.2 bits (134), Expect = 2e-07
Identities = 195/1012 (19%), Positives = 382/1012 (37%), Gaps = 149/1012 (14%)
Query: 142 LFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQSQK 201
L K L+E + + Q+K+Q +L +++ ++ + + Q L DQ K
Sbjct: 71 LKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIAL-------QDQLLK 123
Query: 202 HRSPGNTT---TGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDF--VLTS 256
+S + G AT S+ Y +SH S F DF +++S
Sbjct: 124 LQSAAQSVPSGAGVPATTASSSFAYG------------ISHHPSAF-HDDDMDFGDIISS 170
Query: 257 KRASPNLFSEAQYQEAPVEK-----NNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQ 311
++ L +E E+ V K + ++ I + + +++++ + +
Sbjct: 171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEID 230
Query: 312 KHD-DSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAK 370
H + S + N ++ + ++ DY EE+I+ E L+Q E L +
Sbjct: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDY-EERIEELENLLQQGGSGVIETDLSKIYE 289
Query: 371 PKQPF----LKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTAL 426
++ +++ E + + K K KL S D+ + + +++QL +
Sbjct: 290 MQKTIQVLQIEKVESTKKMEQLEDKI-KDINKKL---SSAENDRDILRREQEQLN----V 341
Query: 427 KNKELCADNPILKKDSKARTKSG---SVTLSQKPKMLKCSN--------RKSLSPSG--- 472
+ +++ + LK + S S T+++K ++L S +++LS +
Sbjct: 342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Query: 473 LKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGP 532
+++ + + + D +K + ++ KE +Q K+ L +S
Sbjct: 402 MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL--------------LSQEKEELQMSL-- 445
Query: 533 ASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSS 592
+L + + ++ + SLD L E ++++ N + E L +E+ +
Sbjct: 446 -LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQN 504
Query: 593 NSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTA-----REK 647
+ IL +DQ + K + + + Q N H + +D T +EK
Sbjct: 505 QEATKHMILIKDQ-LSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK 563
Query: 648 ESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSE 707
+ EVA LH + K E++ E N D + S S S
Sbjct: 564 LIQSEVALNDLH------------------LTKQKLEDKVE-NLVDQ--LNKSQESNVSI 602
Query: 708 EQLDVTIKPSTEDRERGISS-REDSPQVC--DDKGPFKDTRTQEDKRRDVDLDLSDKDYS 764
++ ++ +K E +S R + Q D FKDT +E R+ ++ ++ S
Sbjct: 603 QKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE---REAEVRNLKQNLS 659
Query: 765 SDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQT 824
E + E++K + + K+ E LEE L ++ + ++T
Sbjct: 660 ELEQLNENLKKVAFDVKMENE----KLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLK 715
Query: 825 CYPNNEIGILDKTIKRKIAPVKRGED-LSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHL 883
L KR + + E + + +R+ TS L ++ +K K D +
Sbjct: 716 MEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEI 775
Query: 884 GNELKLNISQ---DQPPGDNARSQVLREK------IIELETEIEKFKAENASLAKLRIER 934
ELK NI Q D + S L E+ I + E IEK K ++ KL+ E
Sbjct: 776 A-ELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSS---KLQEEL 831
Query: 935 ESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKERE 994
+ + LRK + +Q +E R KEE LQ+E + + + D K +
Sbjct: 832 DKYSQALRKN--EILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
Query: 995 EIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRL---- 1050
+ L +++ L + E + + Q Q ++ L+E+ K M+ FR
Sbjct: 890 SVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQ 949
Query: 1051 -----------------DAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISS 1085
K E I++ L E++D + S FQ +++ S
Sbjct: 950 MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001
Score = 37.4 bits (85), Expect = 0.097
Identities = 46/206 (22%), Positives = 98/206 (47%), Gaps = 26/206 (12%)
Query: 906 LREKIIELETEIEKFKAENASLAKLRIERES---ALEK--------LRKEIADFEQQKAK 954
L+E+I+ LE +I K K EN + + +E+ AL++ LR++ + K K
Sbjct: 1447 LKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEK 1506
Query: 955 ELARIEEFKKEEMRKLQKERKVFEKY-TTAARTFPDKKEREEIQ-TLKQQIAD---LRED 1009
LA + K++E K + ++ + +T ++ER+++ LKQ+ + L+ +
Sbjct: 1507 ALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNE 1566
Query: 1010 LKR-KETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKK 1068
++R ++ ++ S R + +L E++ RE + +R K+ +E
Sbjct: 1567 VQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDR-EAKLRKKVTVLE-------- 1617
Query: 1069 DKLANTSVRFQNSQISSGTQVEKYKK 1094
+KL ++S +N+ + QVE ++
Sbjct: 1618 EKLVSSSNAMENASHQASVQVESLQE 1643
Score = 32.3 bits (72), Expect = 3.1
Identities = 93/495 (18%), Positives = 191/495 (38%), Gaps = 56/495 (11%)
Query: 536 LAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEF---------------LF 580
L K T++E+ L S+ E +E E+ + E+ + L
Sbjct: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
Query: 581 LEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDL 640
++ +D++ SSN +F K+ E + R + T +K D +E +
Sbjct: 1416 IKAKSDQL-LSSNENFTNKVNENELL-----RQAVTNLKERILILE-MDIGKLKGENEKI 1468
Query: 641 DHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNS 700
T R KE+E + Q ++ + LRE+ + +K+ + Q ++ E
Sbjct: 1469 VETYRGKETEYQAL--QETNMKFSMMLREKEFECHSMKEKALAFEQL---LKEKE----- 1518
Query: 701 DSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSD 760
T QL +K S +++ D + + ++T Q + +R L D
Sbjct: 1519 QGKTGELNQLLNAVK-SMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQR-----LRD 1572
Query: 761 KDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDE--RTWTDLEENLCNHDVVLGNEST 818
K++ S++ + H + + +L+ D + + + T LEE L + + N S
Sbjct: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASH 1632
Query: 819 YGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPK 878
+ Q ++ ++ K + ++ K + + S +++++ F + K
Sbjct: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQVK-QYALSLANLQMVLEHFQQ-EEKAM 1690
Query: 879 SDSHLGNELKLNISQDQPPGDNARSQV--LREKIIELETEIEKFK--AENASLAKLRIER 934
+ L + +L I++ + +N +V L+E + E ++ E + + +IE
Sbjct: 1691 YSAELEKQKQL-IAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEE 1749
Query: 935 ESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKERE 994
+LR+E+ D Q+K LA E K + KV + K +R
Sbjct: 1750 LKRQNELRQEMLDDVQKKLMSLANSSEGKVD---------KVLMRNLFIGHFHTPKNQRH 1800
Query: 995 EIQTLKQQIADLRED 1009
E+ L I +R +
Sbjct: 1801 EVLRLMGSILGVRRE 1815
>gi|222537750 ankyrin repeat domain 30B [Homo sapiens]
Length = 1392
Score = 55.8 bits (133), Expect = 3e-07
Identities = 136/680 (20%), Positives = 247/680 (36%), Gaps = 83/680 (12%)
Query: 404 QSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKAR--------TKSGSVTLSQ 455
+ S +P +M + + LKN++ + +SK + ++S T+SQ
Sbjct: 527 EKPSAFKPAVEMQKTVPNKAFELKNEQTLRAAQMFPSESKQKDDEENSWDSESPCETVSQ 586
Query: 456 KPKML-KCSNRKSLSPSGLKIQTGKKCDGQFRD----QIKFENKVTSNNKENVTECPKPC 510
K L K +++K K++ DG + ++ NK + P
Sbjct: 587 KDVYLPKATHQKEFDTLSGKLEESPVKDGLLKPTCGRKVSLPNKALELKDRETFKAESPD 646
Query: 511 DTGCTGWNKTQG-KDRLP---LSTGPASRLAAKSPIRETMKESESSLDVSLQKK-LETWE 565
G T G K LP L L A+SP + + + VSL K LE +
Sbjct: 647 KDGLL--KPTCGRKVSLPNKALELKDRETLKAESPDNDGLLKPTCGRKVSLPNKALELKD 704
Query: 566 REKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMS-----STPVKA 620
RE K +Q DE + SF+ +L+ D + K S ++
Sbjct: 705 RETFKAAQMFPSES--KQKDDEENSWDFESFLETLLQNDVCLPKATHQKEFDTLSGKLEE 762
Query: 621 VPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQK 680
P K P C L + A E + + + S+ S L +P
Sbjct: 763 SPDKDGLLKPT--CGMKISLPNKALELKDRETFKAEDVSSVESTFSLFGKP--------- 811
Query: 681 STSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGP 740
T+EN +D + + +T K T +ER I E +PQ +K P
Sbjct: 812 -TTENSQSTKVEEDFNLTTKEGAT----------KTVTGQQERDIGIIERAPQDQTNKMP 860
Query: 741 FKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWT 800
+ +ED + D ++ + + + ++ + + + S T
Sbjct: 861 TSELGRKEDTKSTSDSEIISVSDTQNYECLPEATYQKEIKTTNGKIEESPEKPSHFEPAT 920
Query: 801 DLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSR----R 856
+++ ++ N + N+ T T ILD + +RG +L K
Sbjct: 921 EMQNSVPNKGLEWKNKQTLRADSTTLSK----ILD-----ALPSCERGRELKKDNCEQIT 971
Query: 857 SRSPPTSELMMKFFPSLKPKPKSDSHLGNE----------LKLNISQDQPPGDNARSQVL 906
++ T L + S L N+ ++L ++Q++ N +L
Sbjct: 972 AKMEQTKNKFCVLQKELSEAKEIKSQLENQKAKWEQELCSVRLTLNQEEEKRRNV--DIL 1029
Query: 907 REKIIELETEIEKFKAENASLAKLR---IERESALEKLRKEIADFEQQKAKELARIEEFK 963
+EKI E +K + + LR IE +S L + + +L
Sbjct: 1030 KEKIRPEEQLRKKLEVKQQLEQTLRIQDIELKSVTSNLNQ--VSHTHESENDLFHENCML 1087
Query: 964 KEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSR 1023
K+E+ L+ E + + K E+I+ L+++ A+L+ LK K+ + S+
Sbjct: 1088 KKEIAMLKLEVATLKH----QHQVKENKYFEDIKILQEKNAELQMTLKLKQKTVTKRASQ 1143
Query: 1024 LRSQIQMLVRENTDLREEIK 1043
R Q+++L ENT L ++K
Sbjct: 1144 YREQLKVLTAENTMLTSKLK 1163
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 55.8 bits (133), Expect = 3e-07
Identities = 119/599 (19%), Positives = 218/599 (36%), Gaps = 91/599 (15%)
Query: 547 KESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQ 606
K ++++ V+L+ E W+++ EKE ++ L+ + N + + D+Q
Sbjct: 325 KTIKNTVSVNLELTAEEWKKKYEKEK---EKNKTLKNVIQHLEMELNRWRNGEAVPEDEQ 381
Query: 607 ICKGHRMSSTPVKAVPQKTNPADPISHCNRSE-------------DLDHTAREKESECEV 653
I + + P P N A ++ + E LD E + ++
Sbjct: 382 ISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQSQL 441
Query: 654 APKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVT 713
A K + DEL + + +Q+ + Q E A DE + E+L V
Sbjct: 442 AEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDE----VKEVLQALEELAVN 497
Query: 714 IKPSTEDRERGISSREDSPQVCDDK-----------GPFKDTRTQEDKRRDVDLDLSDKD 762
+++ E + E K ++ + KR L+L KD
Sbjct: 498 YDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELSNHQKKRATEILNLLLKD 557
Query: 763 Y--------SSDESIMESIKHKVSEPSRSSSLSLSKM-----------------DFDDER 797
++D + + + E + L +SKM D R
Sbjct: 558 LGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKSLVNRSKQLESAQMDSNR 617
Query: 798 TWTDLEENLCNHDVVLGNESTYGTPQTCYPNN------EIGILDKTIKRKIAPVKRGE-- 849
E L +++ T Y N ++ ++ ++A ++ E
Sbjct: 618 KMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEESQDSLSEELAKLRAQEKM 677
Query: 850 ------DLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARS 903
D K +R E+ ++ ++ + L+ I + Q D R
Sbjct: 678 HEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSRLRDEIEEKQKIIDEIRD 737
Query: 904 QVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFK 963
L +K L+ E EK ++ L ERE LEKL + D +Q ++L +EE
Sbjct: 738 --LNQK---LQLEQEKLSSDYNKLKIEDQEREMKLEKLLL-LNDKREQAREDLKGLEETV 791
Query: 964 KEEMRKLQKERKVF-EKYTTAARTFP--DKKEREEIQTLKQQIADLREDLKRKETKWSST 1020
E++ L RK+F + TT + D + KQ+I+ L +L++
Sbjct: 792 SRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENNLEQ-------- 843
Query: 1021 HSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQ 1079
L + LVR+N DLR E+ +E+ +R +A+ES+L+ E K+ R+Q
Sbjct: 844 ---LTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALK-EAKENAMRDRKRYQ 898
Score = 30.8 bits (68), Expect = 9.1
Identities = 47/202 (23%), Positives = 82/202 (40%), Gaps = 29/202 (14%)
Query: 216 CCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRASPNLFSEAQYQEAPVE 275
CC PS + ET + + T + LT++ E + ++
Sbjct: 303 CCSPSVF----NEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKY--EKEKEKNKTL 356
Query: 276 KN---NLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIG 332
KN +L+ E GE++ EQI + KNL+ D++ + NI P+ A I
Sbjct: 357 KNVIQHLEMELNRWRNGEAV----PEDEQISAKDQKNLEPCDNTPIIDNI--APVVAGIS 410
Query: 333 -ERKQTFED---YLEEQIQLEEQEL-KQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTN 387
E K+ +++ L Q+ ++ E+ +Q QL E K KQ L + E LA
Sbjct: 411 TEEKEKYDEEISSLYRQLDDKDDEINQQSQLAE---------KLKQQMLDQDELLASTRR 461
Query: 388 AKSKFQKGKESKLVTNQSTSED 409
K Q+ + N++ ++
Sbjct: 462 DYEKIQEELTRLQIENEAAKDE 483
>gi|105553088 t-complex 10 [Homo sapiens]
Length = 326
Score = 55.8 bits (133), Expect = 3e-07
Identities = 48/201 (23%), Positives = 91/201 (45%), Gaps = 22/201 (10%)
Query: 978 EKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037
EK AA + E+ +L+QQI L ++L R+++ W+ H +L+S + L ++N +
Sbjct: 2 EKTPAAAEVPREDSNAGEMPSLQQQITSLHQELGRQQSLWADIHRKLQSHMDALRKQNRE 61
Query: 1038 LREEIKVMERFRLDAWKRAE------------AIESSL-EVEKKDKLANTSVRFQNSQIS 1084
LREE++ ++R + +A K+ A+E + ++ +T+ ++ +
Sbjct: 62 LREELRGLQRQQWEAGKKPAASPHAGRESHTLALEPAFGKISHLSADEDTTPKYAGRKSQ 121
Query: 1085 SGTQV-EKYKKNYL----PMQGNPPR-RSKSAPPRDLGNLDKGQAASPREPLEPLNFPDP 1138
S T + +++ N+L PM R S PP++ R P P P P
Sbjct: 122 SATLLGQRWSSNHLAPPKPMSLKTERINSGKTPPQEDREKSPPGRRQDRSP-APTGRPTP 180
Query: 1139 EYKEEEEDQDIQGEISHPDGK 1159
+ +D G+I HP +
Sbjct: 181 GAERRGVSED--GKIMHPSSR 199
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 54.7 bits (130), Expect = 6e-07
Identities = 155/887 (17%), Positives = 358/887 (40%), Gaps = 82/887 (9%)
Query: 227 TQEETYPSNILSH-EQSNFCRTAHGDFVLTSKRASP------NLFSEAQYQEAPVEKNNL 279
+ EE + + + +H + SN ++A D S + L EA ++ + L
Sbjct: 270 SMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLL 329
Query: 280 K-EENRNHPTGESILCWEKVTEQIQEAND---KNLQKHDDSSEVANIEERPIKAAIGE-- 333
+ E++++ E + ++ ++++ AND +K SE P AA+ +
Sbjct: 330 EVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIV 389
Query: 334 -----RKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNA 388
+ + Y+E Q QL ++L+ K++ + + + + K P LKR
Sbjct: 390 KPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKR---------Q 440
Query: 389 KSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKS 448
+ ++++ + K V + S +Q + ++ Q+LQ T NK+ + +L++D++ R +
Sbjct: 441 REEYERAQ--KAVASLSVKLEQAMKEI--QRLQEDTDKANKQ----SSVLERDNR-RMEI 491
Query: 449 GSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPK 508
LSQ+ ++L ++ ++ + D ++ ++ V+ N E + + +
Sbjct: 492 QVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQ 551
Query: 509 PCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREK 568
+T+ ++ ++ + L K + + E E L S Q +++ +
Sbjct: 552 RLLVALRELGETREREEQETTSSKITELQLK--LESALTELE-QLRKSRQHQMQLVDSIV 608
Query: 569 EKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPA 628
+ ++ L + I ++S + + ++ +S+ V + T
Sbjct: 609 RQR--DMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI 666
Query: 629 DPISHCNRSEDL-DHTAREKESECEVAPKQLHSL-SSADELREQPCKIRKAVQKSTSENQ 686
+ + + +++ ++ +EK ++ +QL L +LR Q KI + Q + +
Sbjct: 667 EAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKI--STQLDFASKR 724
Query: 687 TEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRT 746
E + EG +S Q + +T+ +E+ I++ + ++K + R
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQ---KLTATTQKQEQIINTMTQDLRGANEKLAVAEVRA 781
Query: 747 QEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDD---ERTWTDLE 803
+ K+ L LS+ S + + R +L L+ + ER+ T+ +
Sbjct: 782 ENLKKEKEMLKLSEVRLSQQ-------RESLLAEQRGQNLLLTNLQTIQGILERSETETK 834
Query: 804 ENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTS 863
+ L + L +E ++ + + L + + ++ KR D + +
Sbjct: 835 QRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
Query: 864 ELMMKFFPSLKPKPKSDSHLGN-ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKA 922
+ K +LK HL N E+++ Q G S +E + +L +++ + +
Sbjct: 895 KNAQKEIATLK------QHLSNMEVQVASQSSQRTGKGQPSN--KEDVDDLVSQLRQTEE 946
Query: 923 ENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKE-EMR-------KLQKER 974
+ L + S +E+ + + E+ KE EE +K E+R + Q E+
Sbjct: 947 QVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEK 1006
Query: 975 KVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRE 1034
K+ E DK R I++++QQ+++L++ L + + R + + +
Sbjct: 1007 KLMEVEKEKQELQDDK--RRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQA 1064
Query: 1035 NTDLREEIKV----MERFRLDAWKRAEAIESSLEVEKKDKLANTSVR 1077
D +E+ K+ ++ + A +E +L+ K+ SVR
Sbjct: 1065 RRDCQEQAKIAVEAQNKYERELMLHAADVE-ALQAAKEQVSKMASVR 1110
Score = 43.9 bits (102), Expect = 0.001
Identities = 200/1086 (18%), Positives = 398/1086 (36%), Gaps = 149/1086 (13%)
Query: 146 LEQLKEV------QQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPG--LSLLPDD 197
L+QL+E+ ++ + E+++ +QLE+LQ + + T +S Q +L D+
Sbjct: 672 LKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDN 731
Query: 198 QSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSK 257
R T+ ER + TQ++ N ++ + R A+ +
Sbjct: 732 VEGYRREI--TSLHER------NQKLTATTQKQEQIINTMTQD----LRGANEKLAVAEV 779
Query: 258 RASPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHDDSS 317
RA + + + V + +E G+++L T Q + K SS
Sbjct: 780 RAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSS 839
Query: 318 EVANIEERPIKAAIGERKQTFEDYLEEQI----QLEEQELKQKQLKEAEGPLPIKAKPKQ 373
++ +E I K+ E+ +E++ L+ Q L K+ + E L + K
Sbjct: 840 QIEKLEHE-----ISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELL 894
Query: 374 PFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCA 433
++ + + + Q +S +Q T + QP K D L + +++
Sbjct: 895 KNAQKEIATLKQHLSNMEVQVASQS----SQRTGKGQPSNKEDVDDLVSQLRQTEEQV-- 948
Query: 434 DNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFEN 493
D K R K+ + + Q M+ + + K + + ++ +F+
Sbjct: 949 ------NDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQT 1002
Query: 494 KVTSNNKENVTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETMKESESSL 553
++ E E + D + + LS + + ++ ++E ++ + ++L
Sbjct: 1003 QLEKKLMEVEKEKQELQDDKRRAIESMEQQ----LSELKKTLSSVQNEVQEALQRASTAL 1058
Query: 554 DVSLQKKLETWEREK---EKENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKG 610
Q + + E+ K E +N E + AAD + + V K+ Q + +
Sbjct: 1059 SNEQQARRDCQEQAKIAVEAQNKYERELML--HAADVEALQAAKEQVSKMASVRQHLEET 1116
Query: 611 HRMSSTPV---KAVPQKTNPA--DPISHCN-RSEDLD------HTAREKESECEVAPKQL 658
+ + + + KA ++ D +S C R EDL+ H EK S+ VA +
Sbjct: 1117 TQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKE 1176
Query: 659 H-------SLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPN------------ 699
SLS + +EQ +I + +++ +T + E +
Sbjct: 1177 GVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQ 1236
Query: 700 --SDSSTDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLD 757
DS E++ VT K + E + + ++ V + +E +R + DL
Sbjct: 1237 ELQDSLNAEREKVQVTAKTMAQHEE--LMKKTETMNVVMETNKML---REEKERLEQDLQ 1291
Query: 758 LSDKDYSSDESIMESIKHKVSEPSRSSSL--SLSKMDFDDERTWTDLEENLCNHDV---- 811
E + ++ +E S S + + K+ +D + W ++L +
Sbjct: 1292 QMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDT 1351
Query: 812 ----VLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRG--------EDLSKSRRSRS 859
L +E T + EIG L I R A + EDL+K R +
Sbjct: 1352 EEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKE 1411
Query: 860 PPTSELMMKFFPSLKPKPKSDSH---LGNELK-----LNISQD-------QPPGDNARSQ 904
+L K ++ K K+ + +G K L QD Q GD+
Sbjct: 1412 TIQKDLDAKII-DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQH 1470
Query: 905 V-------LREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELA 957
V L+E + + ET+ + +++ +L K E+E+ L+++ Q EL+
Sbjct: 1471 VSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTV----QLQSELS 1526
Query: 958 RI-EEFKKEEMRKLQKERKVFEKYTTAARTFPDKKER-EEIQTLKQQIADLREDLKRKET 1015
R+ ++ + ++ Q +++ EK + K + + +K Q+ E+LK++
Sbjct: 1527 RLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNG 1586
Query: 1016 KWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTS 1075
L +I L + I +ER + E E LE + + +
Sbjct: 1587 ALDQQKDELDVRITAL---KSQYEGRISRLER------ELREHQERHLEQRDEPQEPSNK 1637
Query: 1076 VRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSK-----SAPPRDLGNLDKGQAASPREPL 1130
V Q QI+ T ++ P K S P + G ++PR +
Sbjct: 1638 VPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASI 1697
Query: 1131 EPLNFP 1136
P+ P
Sbjct: 1698 RPMVTP 1703
Score = 39.3 bits (90), Expect = 0.026
Identities = 41/214 (19%), Positives = 91/214 (42%), Gaps = 15/214 (7%)
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
E +L+ SQ++ + Q LR ++ +L +++ +N L ++ +R A++
Sbjct: 58 EKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL-EIAQDRNIAIQSQFTRT 116
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
+ + + ++L R E +E+ L ++ K + + +E T K ++
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNE------------KLKESNTTKGELQL 164
Query: 1006 LREDLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVM--ERFRLDAWKRAEAIESSL 1063
++L+ + RL + ++L +NT L E+K E L K E +E
Sbjct: 165 KLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKC 224
Query: 1064 EVEKKDKLANTSVRFQNSQISSGTQVEKYKKNYL 1097
+E K + + N +S ++K+ ++ L
Sbjct: 225 NLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLL 258
Score = 32.3 bits (72), Expect = 3.1
Identities = 42/183 (22%), Positives = 77/183 (42%), Gaps = 19/183 (10%)
Query: 297 KVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFE-----DYLEEQIQLEEQ 351
K+ + +Q +K L D SE+ ++ R K + +Q FE + +E++ E +
Sbjct: 16 KLPKSVQNKLEKFLA--DQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETR 73
Query: 352 ELKQKQLKEAEGPLPIKA---KPKQPFLKRGEGLA---RFTNAKSKFQKGKESKLVTNQS 405
E + +L+ + +KA K K+ + + +A +FT K + + K + TN+
Sbjct: 74 ECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNER 133
Query: 406 TSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKD----SKARTKSGSVTLSQKPKMLK 461
S++ D ++L K LK LK D S K L Q+ ++L
Sbjct: 134 LSQELEYLTEDVKRLNEK--LKESNTTKGELQLKLDELQASDVSVKYREKRLEQEKELLH 191
Query: 462 CSN 464
N
Sbjct: 192 SQN 194
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 54.3 bits (129), Expect = 8e-07
Identities = 131/741 (17%), Positives = 274/741 (36%), Gaps = 93/741 (12%)
Query: 296 EKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEEQELKQ 355
E+ ++++ + ++ + ++ + + E R K + + + ++D L ++ L+ +
Sbjct: 343 ERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAY 402
Query: 356 KQLKEAE------GPLPIKAKPKQPFLKRGEGLARFTNAKSK-----FQKGKESKLVTNQ 404
++L E E GP+P P + ++ KS+ +K ++ ++ +
Sbjct: 403 RKLLEGEECRIGFGPIPFSLPEGLPKIP---SVSTHIKVKSEEKIKVVEKSEKETVIVEE 459
Query: 405 STSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCSN 464
T E Q ++ ++ + + KE + + TKS + P+ S
Sbjct: 460 QTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519
Query: 465 RKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGKD 524
K + S + ++ +K + + ++K K S KE P+ K+ K+
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA---------KSPEKE 570
Query: 525 RLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQA 584
S AKSP +E E++S + +K ++ +E+ K E A
Sbjct: 571 EAKSPAEVKSPEKAKSPAKE---EAKSPAEAKSPEKAKSPVKEEAKSPAE---------A 618
Query: 585 ADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTA 644
+ + S +K E+ + K S K+ P+K P E
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS-PEKEEAKSP-------EKAKSPV 670
Query: 645 REKESECEVAPKQLHSLSSADELREQPCKIR-KAVQKSTSENQTEWNARDDEGVPNSDSS 703
+ + E A + + + + E + P K K+ +K+ S + E + + P + +
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 730
Query: 704 TDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDY 763
+ E+ +K + E+ S + + D K P T +E+ R D
Sbjct: 731 K-TPEKAKSPVKEEAKSPEKAKSP--EKAKTLDVKSPEAKTPAKEEARSPAD-------- 779
Query: 764 SSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQ 823
E +K +V P ++ S L+E+ P+
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKS---------------PLKEDA-------------KAPE 811
Query: 824 TCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHL 883
P E + K VK E K+ ++P T + K + PK ++
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAP- 870
Query: 884 GNELKLNISQDQPPG-DNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLR 942
K + + + P + + + K E E + + E + AK+ + +E A K +
Sbjct: 871 ----KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEV-KEDAKPKEK 925
Query: 943 KEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQ 1002
E+A E AK + +K+E +K+ K + + + K +E+ +TL ++
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Query: 1003 IADLREDLKRKETKWSSTHSR 1023
+ + + K K SST +
Sbjct: 986 PSKPKAE---KAEKSSSTDQK 1003
Score = 46.2 bits (108), Expect = 2e-04
Identities = 103/553 (18%), Positives = 199/553 (35%), Gaps = 89/553 (16%)
Query: 259 ASPNLFSEAQYQE---APVEKNNLKEENRNHPTGESILCWEKVTEQI-QEANDKNLQKHD 314
ASP +++ +E +P E + ++E P + EK +EA K
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA--EVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 315 DSSEVANIEE--RPIKAAIGERKQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPK 372
+ E + E P KA +++ + + + +K++ AE P+K + K
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 373 QPFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELC 432
P + K+K +E+K + E + ++ + K K+ E
Sbjct: 628 SPAEVKSP-------EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Query: 433 ADNPILKKDSKARTKSGSVTLSQKPKMLKC-------SNRKSLSPSGLKIQTGKKCDGQF 485
+ S + KS ++ P+ K S K+ SP + +T +K
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740
Query: 486 RDQIKFENKVTSNNKENVTECPKP------CDTGCTGWNKTQGKDRLPLSTGPASRLAAK 539
+++ K K S K + P + + +K K + P+ S AK
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK 800
Query: 540 SPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLK 599
SP++E K E + + K E EK +E +K
Sbjct: 801 SPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE--------------------------VK 834
Query: 600 ILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLH 659
+ E P K ++ PA P T +K+S+ E APK+
Sbjct: 835 VKE--------------PPKKAEEEKAPATP-----------KTEEKKDSKKEEAPKKEA 869
Query: 660 SLSSADELR----EQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDS--EEQLDVT 713
+E + E+P + + +K +E++ + + E + D+ +E+ +V
Sbjct: 870 PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929
Query: 714 IKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESI-MES 772
K + + + S + + +K KDT+ ++ K+ + K D+++ E
Sbjct: 930 KKEPDDAKAKEPSKPAEKKEAAPEK---KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986
Query: 773 IKHKVSEPSRSSS 785
K K + +SSS
Sbjct: 987 SKPKAEKAEKSSS 999
Score = 33.1 bits (74), Expect = 1.8
Identities = 54/255 (21%), Positives = 103/255 (40%), Gaps = 32/255 (12%)
Query: 907 REKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFE---QQKAKELARIEEFK 963
R ++ TE+E K+ SL + R E E ++ + +IA ++ QQ EL +
Sbjct: 322 RRQLQARTTELEALKSTKDSLERQRSELE---DRHQADIASYQEAIQQLDAELRNTKWEM 378
Query: 964 KEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIA-DLREDLKRKETKWSSTHS 1022
++R+ Q V + E EE + I L E L + + STH
Sbjct: 379 AAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSV--STHI 436
Query: 1023 RLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQ 1082
+++S+ ++ V E ++ +E + V E+ + + E + E E K++ + +
Sbjct: 437 KVKSEEKIKVVEKSE-KETVIVEEQ--TEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEE 493
Query: 1083 ISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKE 1142
G + K +PP ++P ++ + K +A SP E P
Sbjct: 494 AEGGEEETK----------SPPAEEAASPEKEAKSPVKEEAKSPAEAKSP---------- 533
Query: 1143 EEEDQDIQGEISHPD 1157
E+E+ E+ P+
Sbjct: 534 EKEEAKSPAEVKSPE 548
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 54.3 bits (129), Expect = 8e-07
Identities = 188/986 (19%), Positives = 388/986 (39%), Gaps = 132/986 (13%)
Query: 140 DPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLMEEQEKLLTMVSGQCTLPGLSLLPDDQS 199
D L + E+LKE Q+ QE K+QQL +Q M E +K + + L ++
Sbjct: 1120 DRLAEVEEKLKEKSQQLQE--KQQQLLNVQEEMSEMQKKINEIEN---------LKNELK 1168
Query: 200 QKHRSPGNTTTGERATCCFPSYVYPDPTQEETYPSNILSHEQSNFCRTAHGDFVLTSKRA 259
K + + T ER + + T +L Q +F D + R
Sbjct: 1169 NKELTLEHMET-ERLELAQKLNENYEEVKSITKERKVLKELQKSF--ETERDHLRGYIRE 1225
Query: 260 SPNLFSEAQYQEAPVEKNNLKEENRNHPTGESILCWEKVTEQIQEANDKNLQKHD-DSSE 318
+ + +E + +LKE E+I +++ + E + + D + S
Sbjct: 1226 IEATGLQTK-EELKIAHIHLKEHQ------ETI---DELRRSVSEKTAQIINTQDLEKSH 1275
Query: 319 VANIEERPIKAAIGERKQTFEDYLEEQIQLEEQEL--KQKQLKEAEGPLPI---KAKPKQ 373
EE P+ E ++ E Q + E EL +Q K++ I + + +
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 374 PFLKRGEGLARFTNAKSKFQKGKESKLVTNQSTSED--QPLFKMDRQQLQRKTALKNKEL 431
F + E + T + + KE+ V + E + L K+ Q +++ +L KE
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 432 CADNPILKKDSKARTKSGSVTLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKF 491
+ + + + S L + +ML S R S +K +K D Q ++
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVL- 1454
Query: 492 ENKVTSNNKENVTEC-PKPCDTG-------CTGWNKTQGKDRLPLSTGPASRLAAKSPIR 543
+ KEN+ E K +T C + + + L ++ L+ K
Sbjct: 1455 -QSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVN------LSEKETEI 1507
Query: 544 ETMKESESSLDVSLQKKLETWEREKEKENL-----------ELDEFLFLEQAADEISFSS 592
T+++ +++ LQ K++ ++E+ N+ EL +F +A D S+
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKD----SA 1563
Query: 593 NSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTARE---KES 649
S K+LE ++ + +K + + + + L +E K
Sbjct: 1564 LQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI--ERDQLKENTKEIVAKMK 1621
Query: 650 ECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQ 709
E + Q +++ +E +E+ C+I ++ ++ N + E + + ++ E+
Sbjct: 1622 ESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI-ETENIRLTQILHENLEE 1680
Query: 710 LDVTIKPSTEDRERGISSREDSPQVCDD--KGPFKDTRTQEDKRRDVDLDLSDKDYSSDE 767
+ + T++R+ + S E++ +V D K ++T T++ ++++ +L + +
Sbjct: 1681 M----RSVTKERD-DLRSVEETLKVERDQLKENLRETITRDLEKQE-ELKIVHMHLKEHQ 1734
Query: 768 SIMESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYP 827
++ ++ VSE + +S M D E + + L D+ + E
Sbjct: 1735 ETIDKLRGIVSEKTNE----ISNMQKDLEHS----NDALKAQDLKIQEELRIAHMHLKEQ 1786
Query: 828 NNEIGILDKTIKRKIAPVKRGE-DLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNE 886
I L + K + + DL S EL K++ H
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQEL------------KANEHQLIT 1834
Query: 887 LKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIA 946
LK ++++ Q +K+ E+E ++ K ++ +L+KL IE + +KL + +
Sbjct: 1835 LKKDVNETQ------------KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
Query: 947 DFE--QQKAKELARIEEFKKEEMRKLQ--------KERKVFEKYTTAARTFPDKKE---- 992
+ + ++ L R+EE K E +L+ ++ ++ ++ TA + KE
Sbjct: 1883 EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDK 1942
Query: 993 -REEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDL---REEIKVMERF 1048
RE+I QI+D+++DL + + + L+ + L+R D+ ++I ME+
Sbjct: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQL 2002
Query: 1049 RLDAWKRAEAIESSLEVEKKDKLANT 1074
+ K+ EA S++ + D T
Sbjct: 2003 K----KQFEAQNLSMQSVRMDNFQLT 2024
Score = 53.9 bits (128), Expect = 1e-06
Identities = 202/1056 (19%), Positives = 407/1056 (38%), Gaps = 144/1056 (13%)
Query: 118 QEENKNDFIPDLASEFKE-----GAYKDPLFKKLEQLKEVQQKKQEQLKRQQLEQLQRLM 172
+ E N I +L+ E ++ GA K L K ++L+E ++ QE+L ++EQL+ +
Sbjct: 839 ENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN--EMEQLKEQL 896
Query: 173 EEQEKLLTMVSGQCTLPGLSLLPDDQSQKHRSPGNTTTGERATCCFPSYVYPDPTQEETY 232
E ++ L V + TL L + K + + +T
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956
Query: 233 PSNILSHEQSNFCRTA---HGDFVLT-----SKRASPNLFSEA-------QYQEAPV--- 274
NI + EQ + H + + T S+ S NL E ++Q+ V
Sbjct: 957 NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGID 1016
Query: 275 EKNNLKEENRNHPTG-----ESILCWEKVTEQIQEANDKNLQKHDDSSEVANIEERPIKA 329
+K +L+ +N T E I K+ IQE N+ LQ+ +S E+ +K
Sbjct: 1017 KKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE--LQQMLES---VIAEKEQLKT 1071
Query: 330 AIGER-KQTFEDYLEEQIQLEEQELKQKQLKEAEGPLPIKAKPKQPFLKRGEGLARFTNA 388
+ E + T E+ +E+++L ELK++Q I A+ K +K+ L+R +
Sbjct: 1072 DLKENIEMTIEN--QEELRLLGDELKKQQ--------EIVAQEKNHAIKKEGELSRTCDR 1121
Query: 389 KSKFQKGKESKLVTNQSTSEDQPLFKMDRQQLQRK--------TALKNKELCADN----- 435
++ ++ + K Q + + + ++Q+K LKNKEL ++
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181
Query: 436 -PILKKDSKARTKSGSVTLSQKP-KMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFEN 493
+ +K ++ + S+T +K K L+ S I+ + Q ++++K +
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 494 KVTSNNKENVTECPKPCDTGCTGWNKTQG--------KDRLPLSTGPASRLA---AKSPI 542
++E + E + TQ ++ +P+ L S
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 543 RETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSNSSFVLKILE 602
+ETM E E + S K T R E E L L+E +++ +EI + LK ++
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARI-EMERLRLNEKF--QESQEEIKSLTKERDNLKTIK 1358
Query: 603 RDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLS 662
++ H ++ K I ++ +EK++E ++
Sbjct: 1359 EALEV--KHDQLKEHIRETLAK------IQESQSKQEQSLNMKEKDNETTKIVSEMEQFK 1410
Query: 663 SADE----LREQPCKIRKAVQKSTSENQTEWNARDD----EGVPNSDSSTDSEEQLDVTI 714
D + + + K +Q+S E ++ +DD + V S+S E ++
Sbjct: 1411 PKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA 1470
Query: 715 KPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSD------ES 768
K + E ++ C + QE+ ++ ++LS+K+ E+
Sbjct: 1471 KHLETEEELKVA------HCC--------LKEQEETINELRVNLSEKETEISTIQKQLEA 1516
Query: 769 IMESIKHKVSEP-SRSSSLSLSKMDFDDERT--WTDLEENLCNHDVVLGNESTYGTPQTC 825
I + +++K+ E + ++ ++ E+ +E+ D L + + T
Sbjct: 1517 INDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 826 YPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGN 885
+ IK K + E L R T E++ K +K + +
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK----MKESQEKEYQFLK 1632
Query: 886 ELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEI 945
+N +Q++ + L+E+ + +E + EN L ++ E + + KE
Sbjct: 1633 MTAVNETQEKM----CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKER 1688
Query: 946 ADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIAD 1005
D L +EE K E +L++ + T R D +++EE++ + + +
Sbjct: 1689 DD--------LRSVEETLKVERDQLKENLR-----ETITR---DLEKQEELKIVHMHLKE 1732
Query: 1006 LREDLKRKETKWSSTHSRLRSQIQMLVRENTDLR-EEIKVMERFRLDAWKRAEAIES--- 1061
+E + + S + + + + L N L+ +++K+ E R+ E E+
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792
Query: 1062 --SLEVEKKDKLANTSVRFQNSQISSGTQVEKYKKN 1095
+ EK DKL+N +NS ++++ K N
Sbjct: 1793 LRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
Score = 44.7 bits (104), Expect = 6e-04
Identities = 152/815 (18%), Positives = 329/815 (40%), Gaps = 125/815 (15%)
Query: 297 KVTEQIQEAND--KNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQI-QLEEQEL 353
++ E+ QE+ + K+L K D+ + IK A+ + ++++ E + +++E +
Sbjct: 1332 RLNEKFQESQEEIKSLTKERDNLKT-------IKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 354 KQKQ---LKEAEGPLPI------KAKPKQPFLKRGE----GLARFTN---------AKSK 391
KQ+Q +KE + + KPK L R E GL++ AK K
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 392 FQKGKESKLVTNQSTSEDQPLFKMDRQQLQRKTALKNKELCADNPILKKDSKARTKSGSV 451
+ +++ ++S + + ++ + L+ + LK C K+ + V
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCL------KEQEETINELRV 1498
Query: 452 TLSQKPKMLKCSNRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCD 511
LS+K + + +K L K+Q K + + +F K S +E V E
Sbjct: 1499 NLSEKETEIS-TIQKQLEAINDKLQN--KIQEIYEKEEQFNIKQISEVQEKVNELK---- 1551
Query: 512 TGCTGWNKTQGKDRLPLSTGPASRLAAKS-PIRETMKESESSLDVSLQKKLETWEREKEK 570
Q K+ + +K + ++ES+ + + +++K E +R +E
Sbjct: 1552 ---------QFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK-EEMKRVQEA 1601
Query: 571 ENLELDEFLFLEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADP 630
+E D+ L++ EI S E++ Q K T V +K +
Sbjct: 1602 LQIERDQ---LKENTKEIVAKMKES-----QEKEYQFLK-----MTAVNETQEKMCEIEH 1648
Query: 631 ISHCNRSE--DLDHTAREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTE 688
+ ++ +L++ E ++ + L + S + R+ + + ++ +Q +
Sbjct: 1649 LKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK--VERDQLK 1706
Query: 689 WNARDDEGVPNSDSSTDSEEQLDVTI-------KPSTEDRERGISSREDSP--QVCDDKG 739
N R+ + D E+Q ++ I T D+ RGI S + + + D
Sbjct: 1707 ENLRET-------ITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759
Query: 740 PFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTW 799
D +D + +L ++ + ++ ++ VSE + LS M D E +
Sbjct: 1760 HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK----LSNMQKDLENSN 1815
Query: 800 TDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRS 859
L+E + + NE +++ L K + V E L K + +S
Sbjct: 1816 AKLQEKI---QELKANE------------HQLITLKKDVNETQKKVSEMEQLKKQIKDQS 1860
Query: 860 PPTSELMMKFFPSLKPKPKSDSHLGNELKL--NISQDQPPGDNARSQVLREKIIELETEI 917
S+L ++ + ++ + + +K N+ + + R Q L+E + E +
Sbjct: 1861 LTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQ-LKESLQETKARD 1919
Query: 918 EKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVF 977
+ + E + L E + ++KLR++I++ Q + +++ K E +K+Q+ +K
Sbjct: 1920 LEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQK-- 1977
Query: 978 EKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTD 1037
+ + +E++ ++I ++ + K+ E + S S Q+ + +
Sbjct: 1978 -------KELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 1038 LREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLA 1072
L EEI+++ + R D +R I+ SL++E+ +A
Sbjct: 2031 L-EEIRIVAKER-DELRR---IKESLKMERDQFIA 2060
Score = 40.4 bits (93), Expect = 0.011
Identities = 55/270 (20%), Positives = 114/270 (42%), Gaps = 50/270 (18%)
Query: 847 RGEDLSKSRRSRSPPTSELMMK-----FFPSLKPKPKSDSHLGNELK---------LNIS 892
R E+L + + T+ M+ + L+ K K L EL+ ++
Sbjct: 645 RSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLI 704
Query: 893 QDQPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRI------ERESALEKLRKEIA 946
+ P D + L KI +L+ E+ K EN +L + I S +E+LRKEI
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQ 764
Query: 947 DFEQQ------------------KAKELARIEEF--KKEEMRKLQKERK----VFEKYTT 982
D ++ +++ +EE K+++ Q K F+ + T
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 983 AARTFPDKKER--EEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDLRE 1040
F K + EE + + Q+I +L ++ ++ ++ + + L + Q L + +++E
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 1041 EIKVMERFRLDAWKRAEAIESSLEVEKKDK 1070
+ ME+ + ++ E +S+L+ +++K
Sbjct: 885 RLNEMEQLK----EQLENRDSTLQTVEREK 910
Score = 36.2 bits (82), Expect = 0.22
Identities = 43/179 (24%), Positives = 85/179 (47%), Gaps = 21/179 (11%)
Query: 863 SELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFKA 922
+E + K + +LK S + + + N P + +Q+ EKI ELE + + K
Sbjct: 2339 NEKLFKNYQTLKTSLASGAQVNPTTQDN---KNPHVTSRATQLTTEKIRELENSLHEAK- 2394
Query: 923 ENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEFKKEEMRKLQKERKVFEKYTT 982
E+A + +ES + K++KE+ AK A++ E K + + + + +K
Sbjct: 2395 ESA------MHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2448
Query: 983 AARTFPDKKEREEIQTLKQQIADL----REDLKRKETKWSSTHSRLRSQIQM--LVREN 1035
A+ + +EEI+ LK ++ + ++ K E + S+T + + Q ++ L+REN
Sbjct: 2449 GAKPY-----KEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLREN 2502
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 54.3 bits (129), Expect = 8e-07
Identities = 109/563 (19%), Positives = 227/563 (40%), Gaps = 103/563 (18%)
Query: 544 ETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAAD-EISFSSNSSFVLKILE 602
ET KE + + + K E + E +++ LE L++ D ++ S + + E
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906
Query: 603 RDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLHSLS 662
R +Q+ K +K V ++ + I+ +L R+ E EC K +
Sbjct: 907 RCEQLIKNKIQLEAKIKEVTERAEEEEEIN-----AELTAKKRKLEDECSELKKDI---- 957
Query: 663 SADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEEQLDVTIKPSTEDRE 722
D+L K+ K +K +EN+ + + T+ LD TI +++++
Sbjct: 958 --DDLELTLAKVEK--EKHATENKVK-------------NLTEEMAGLDETIAKLSKEKK 1000
Query: 723 RGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSR 782
+ +E Q DD + +EDK +++ K + E ++ ++ + +
Sbjct: 1001 ---ALQETHQQTLDD------LQAEEDK-----VNILTKAKTKLEQQVDDLEGSLEQEK- 1045
Query: 783 SSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKI 842
K+ D ER LE D+ L EST N+ LD+ +++K
Sbjct: 1046 -------KLRMDLERAKRKLEG-----DLKLAQESTMDM------ENDKQQLDEKLEKKE 1087
Query: 843 APVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNAR 902
+ + S+ + ++ +K LG E++ + + + R
Sbjct: 1088 FEIS-------NLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERAS-RAKAEKQR 1139
Query: 903 SQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAKELARIEEF 962
S + RE + E+ +E+ ++ +L +RE+ +KLR+++ + Q +A + +
Sbjct: 1140 SDLSRE-LEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK 1198
Query: 963 KKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTH- 1021
+ M +L ++ + +Q +KQ++ + +LK + SS
Sbjct: 1199 HADSMAEL-------------------GEQIDNLQRVKQKLEKEKSELKMETDDLSSNAE 1239
Query: 1022 --SRLRSQIQMLVRENTDLREEIKVMERFR------LDAWK---RAEAIESSLEVEKKDK 1070
S+ + ++ + R D E+K E + L A + + EA E S ++++KD
Sbjct: 1240 AISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA 1299
Query: 1071 LANTSVRFQNSQISSGTQVEKYK 1093
L + + S+ +S Q+E+ K
Sbjct: 1300 LVS---QLSRSKQASTQQIEELK 1319
Score = 54.3 bits (129), Expect = 8e-07
Identities = 157/838 (18%), Positives = 341/838 (40%), Gaps = 116/838 (13%)
Query: 296 EKVTEQIQEANDKNLQKHDDSSEVANIEERPIKAAIGERKQTFEDYLEEQIQLEE--QEL 353
EK+ ++E ND LQ ++ +A+ EER E ++ +IQLE +E+
Sbjct: 878 EKMVTLLKEKNDLQLQVQSEADSLADAEER------------CEQLIKNKIQLEAKIKEV 925
Query: 354 KQKQLKEAEGPLPIKAKPKQ-----PFLKRGEGLARFTNAKSKFQK-GKESKL--VTNQS 405
++ +E E + AK ++ LK+ T AK + +K E+K+ +T +
Sbjct: 926 TERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 985
Query: 406 TSEDQPLFKMDRQQ--LQRKTALKNKELCADNPILKKDSKARTKSGSVTLSQKPKMLKCS 463
D+ + K+ +++ LQ +L A+ + +KA+TK L Q+ L+ S
Sbjct: 986 AGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTK-----LEQQVDDLEGS 1040
Query: 464 NRKSLSPSGLKIQTGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQGK 523
+ + +K +G + + E+ + N +K Q
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLK--LAQESTMDMEN------------------DKQQLD 1080
Query: 524 DRLPLSTGPASRLAAKSPIRETMKESESSLDVSLQKKLETWEREKEKENLELDEFLFLEQ 583
++L S L +K E E ++++ LQKK++ + E EL E + E+
Sbjct: 1081 EKLEKKEFEISNLISKI-------EDEQAVEIQLQKKIKELQARIE----ELGEEIEAER 1129
Query: 584 AADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHT 643
A+ + S ++ E +++ + +S V+ ++ + L H
Sbjct: 1130 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH- 1188
Query: 644 AREKESECEVAPKQLHSLSSADELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSS 703
E VA + S EL EQ +++ QK E ++E D+ N+++
Sbjct: 1189 ------EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE-KSELKMETDDLSSNAEAI 1241
Query: 704 TDSEEQLDVTIKPSTEDRERGISSREDSPQVCDDKGPFKDTRTQE---------DKRRDV 754
+ ++ L+ + S ED+ + ++E+ Q + + R Q D++ +
Sbjct: 1242 SKAKGNLEKMCR-SLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDAL 1300
Query: 755 DLDLSDKDYSSDESIMESIKHKVSEPSRSS-----SLSLSKMDFD--------DERTWTD 801
LS +S + I E +KH++ E +++ +L S+ D D ++ +
Sbjct: 1301 VSQLSRSKQASTQQI-EELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1359
Query: 802 LEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPP 861
L+ L + + T E+ K + +++ + + ++ +
Sbjct: 1360 LQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEK 1419
Query: 862 TSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKFK 921
T + + L D N + + Q D S+ ++K E + E+E +
Sbjct: 1420 TKQRLQNEVEDL----MLDVERSNAACAALDKKQRNFDKVLSE-WKQKYEETQAELEASQ 1474
Query: 922 AENASLA----KLRIERESALEK----------LRKEIADFEQQKAKELARIEEFKKEEM 967
E+ SL+ K++ E +L++ L++EI+D +Q A+ +I E +K +
Sbjct: 1475 KESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKK 1534
Query: 968 RKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRL-RS 1026
+ Q++ ++ A + + E +I ++ ++ ++ ++ RK + +L R+
Sbjct: 1535 QVEQEKCEIQAALEEAEASL--EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1592
Query: 1027 QIQMLVRENTDLREEIKVM-ERFRLDAWKRAEAIESSLEVEKKDKLANTSVR-FQNSQ 1082
+++ + L EI+ + R+ + E +++ ++LA S+R ++N+Q
Sbjct: 1593 HTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQ 1650
Score = 47.0 bits (110), Expect = 1e-04
Identities = 141/716 (19%), Positives = 281/716 (39%), Gaps = 126/716 (17%)
Query: 440 KDSKARTKSGSVTLSQKP-KMLKCSNRKSL---SPSGLKIQTGKKCDGQFRDQIKFENK- 494
KD A++++ L +K +LK N L S + ++C+ +++I+ E K
Sbjct: 863 KDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKI 922
Query: 495 --VTSNNKEN------VTECPKPCDTGCTGWNKTQGKDRLPLSTGPASRLAAKSPIRETM 546
VT +E +T + + C+ K L L+ + A ++ ++
Sbjct: 923 KEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 982
Query: 547 KE-------------SESSLDVSLQKKLETWEREKEKENLELDEFLFLEQAADEISFSSN 593
+E + +L + Q+ L+ + E++K N+ LEQ D++ S
Sbjct: 983 EEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLE 1042
Query: 594 SSFVLKI-LERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECE 652
L++ LER ++ +G +K + T + N + LD +KE E
Sbjct: 1043 QEKKLRMDLERAKRKLEGD------LKLAQESTMDME-----NDKQQLDEKLEKKEFEIS 1091
Query: 653 VAPKQLHSLSSAD-ELREQPCKIRKAVQKSTSENQTEWNARDDEGVPNSDSSTDSEE--- 708
++ + + +L+++ +++ +++ E + E +R SD S + EE
Sbjct: 1092 NLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISE 1151
Query: 709 -----------QLDVTIKPSTE------DRERGISSRE-----------DSPQVCDDKGP 740
Q+++ K E D E E DS ++
Sbjct: 1152 RLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQID 1211
Query: 741 FKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEPSRSSSLSLSKMDFDDERTWT 800
Q+ ++ +L + D SS+ + K + + RS +S++ +E
Sbjct: 1212 NLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEE--- 1268
Query: 801 DLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKRKIAPVKRGEDLSKSRRSRSP 860
++ L N D+ T Q E G + + K A V + LS+S+++ +
Sbjct: 1269 --QQRLIN-DL---------TAQRARLQTEAGEYSRQLDEKDALVSQ---LSRSKQASTQ 1313
Query: 861 PTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQVLREKIIELETEIEKF 920
EL + K K N L + + D R Q E+ + E +
Sbjct: 1314 QIEELKHQLEEETKAK--------NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1365
Query: 921 KAENASLAKLR-------IERESALEKLRKEIADFEQQKAKELARIE------EFKKEEM 967
KA N+ +A+ R I+R LE+ +K++A Q+ + + + E K+ +
Sbjct: 1366 KA-NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424
Query: 968 RKLQKERKVFEKYTTAARTFPDKKEREEIQTL---KQQIADLREDLK--RKETKWSST-- 1020
+ ++ + + + AA DKK+R + L KQ+ + + +L+ +KE++ ST
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTEL 1484
Query: 1021 ------HSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKR---AEAIESSLEVEK 1067
+ Q++ L REN +L++EI + + K+ E I+ +E EK
Sbjct: 1485 FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEK 1540
Score = 42.4 bits (98), Expect = 0.003
Identities = 144/825 (17%), Positives = 306/825 (37%), Gaps = 142/825 (17%)
Query: 311 QKHDDSSEVANIEERPIKAAIGERKQT-FEDYLEEQIQLEEQELKQKQLKEAEGPLPIKA 369
Q+ D S E+ I ER +A Q E + Q ++L++ L+ ++
Sbjct: 1138 QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRK 1197
Query: 370 KPKQPFLKRGEGLARFTNAKSKFQKGK-ESKLVTNQSTSEDQP-------LFKMDRQQLQ 421
K + GE + K K +K K E K+ T+ +S + L KM R
Sbjct: 1198 KHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLED 1257
Query: 422 RKTALKNKELCAD---NPILKKDSKARTKSGSVT--LSQKPKMLKCSNRKSLSPSGLKIQ 476
+ + LK KE N + + ++ +T++G + L +K ++ +R Q
Sbjct: 1258 QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK--------Q 1309
Query: 477 TGKKCDGQFRDQIKFENKVTSNNKENVTECPKPCDTGCTGWNKTQ-GKDRLPLSTGPA-S 534
+ + + Q++ E K + + CD + + Q GK L + A S
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1369
Query: 535 RLA-------------------AKSPIRETMKESESSLDVSLQKKLETWEREKEKENLEL 575
+A AK + + ++E+E ++ ++ K + E+ K++ E+
Sbjct: 1370 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVE-AVNAKCASLEKTKQRLQNEV 1428
Query: 576 DEFLF--------------LEQAADEISFSSNSSFVLKILERDQQICKGHRMSSTPVKAV 621
++ + ++ D++ + E + + +S+ K
Sbjct: 1429 EDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVK 1488
Query: 622 PQKTNPADPISHCNR-SEDLDHTAREKESECEVAPKQLHSLSSAD-ELREQPCKIRKAVQ 679
D + R +++L + + KQ+H L ++ ++ C+I+ A++
Sbjct: 1489 NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALE 1548
Query: 680 KSTSENQTEWN-------------ARDDEGVPNSDSSTDSEEQLDVTI---KPSTEDRER 723
++ + + E + D + D D ++ + ST D E
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAE- 1607
Query: 724 GISSREDSPQVCDD-KGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIM------------ 770
I SR D+ +V +G + Q + + + S ++Y + + I+
Sbjct: 1608 -IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAE-SLRNYRNTQGILKETQLHLDDALR 1665
Query: 771 --ESIKHKVSEPSRSSSLSLSKMDFDDERTWTDLEEN-----LCNHDVVLGNESTY--GT 821
E +K +++ R ++L +++ E W LE+ + +++ +E T
Sbjct: 1666 GQEDLKEQLAIVERRANLLQAEI----EELWATLEQTERSRKIAEQELLDASERVQLLHT 1721
Query: 822 PQTCYPN------NEIGILDKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKP 875
T N N++ L ++ I + E+ +K + + +E LK
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAE-------ELKK 1774
Query: 876 KPKSDSHLGNELKLNISQDQPP--------------GDNARSQVLREKIIELETEIEKFK 921
+ + +HL +K N+ Q G + Q L ++ ELE E+E +
Sbjct: 1775 EQDTSAHL-ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQ 1833
Query: 922 AENASLAKLRIERESALEKL-------RKEIADFEQQKAKELARIEEFKKEEMRKLQKER 974
NA K + E +++L RK + + K A+++ +K++ ++
Sbjct: 1834 KRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1893
Query: 975 KVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSS 1019
K+ + +ER +I + Q+ LR + TK S+
Sbjct: 1894 ANLSKFRKLQHELEEAEERADI--AESQVNKLRVKSREVHTKISA 1936
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 53.9 bits (128), Expect = 1e-06
Identities = 90/516 (17%), Positives = 201/516 (38%), Gaps = 60/516 (11%)
Query: 665 DELREQPCKIRKAVQKSTSENQT----EWNARDDEGVPNSDSSTDSEEQLDVTIKPSTED 720
+ELREQ KIRK +K + + E R+ E E++ ++ +
Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 721 RERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIKHKVSEP 780
++ + +E+ Q ++K QE+K R+ + +K + +E + E K +
Sbjct: 301 EQKKLREQEEQMQEQEEK-----MWEQEEKMREQE----EKMWRQEERLWEQEKQMREQE 351
Query: 781 SRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGILDKTIKR 840
KM +ER W E + + E + + I +K ++
Sbjct: 352 Q--------KMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 841 KIAPVKRGEDLSKSRRSR--SPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPG 898
+ ++ E+ + + E + P K K + + + Q++
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 899 DNA----------RSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADF 948
D R + +RE+ ++ + EK + + + E+LR++
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERM 523
Query: 949 EQQKAKELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLRE 1008
+QK ++ + EE +EE + ++E+K +++ +E E ++ ++++ + E
Sbjct: 524 REQK--KMWQQEEKMREEKKTQEQEKKTWDQE-------EKMREEERMREREKKMREEEE 574
Query: 1009 DLKRKETKWSSTHSRLRSQIQMLVRENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKK 1068
++ +E K ++R Q + + + ++E+ + M W++ E + E E++
Sbjct: 575 MMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKM-------WEQEEKM---WEQEEE 624
Query: 1069 DKLANTSVRFQNSQISSGTQVEKYKKNYLPMQGNPPRRSKSAPPRDLGNLDKGQAASPRE 1128
DK+ + Q EK + M R + R+ +GQ RE
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM------REQEEKMREQEEKMQGQEEKMRE 678
Query: 1129 PLEPLNFPDPEYKEEEEDQDIQGEISHPDGKVEKVY 1164
E + + + +E+EE ++G+ G+ EK++
Sbjct: 679 QEEKMQGQEEKMREQEE--KMRGQEEKMWGQEEKMW 712
Score = 42.0 bits (97), Expect = 0.004
Identities = 50/243 (20%), Positives = 98/243 (40%), Gaps = 24/243 (9%)
Query: 917 IEKFKAENASLAKLRIERESALEKLRKEIADFEQQ---KAKELARIEEFKKEEMRKLQKE 973
IE+ E +L+ E+L+K+ A+ +++ E + I+ KE RKL++
Sbjct: 161 IEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERA 220
Query: 974 RKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVR 1033
+ + + T ++ EE++ +++I E + R+E + ++R Q + + R
Sbjct: 221 KFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR 280
Query: 1034 ENTDLREEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQVEKYK 1093
+ LRE+ K E E E+ ++ KL + Q + Q EK +
Sbjct: 281 QEKRLREQEK-------------ELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMR 327
Query: 1094 KNYLPMQGNPPR--------RSKSAPPRDLGNLDKGQAASPREPLEPLNFPDPEYKEEEE 1145
+ M R R + RD Q RE E + + +++EE+
Sbjct: 328 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Query: 1146 DQD 1148
Q+
Sbjct: 388 MQE 390
Score = 42.0 bits (97), Expect = 0.004
Identities = 48/263 (18%), Positives = 119/263 (45%), Gaps = 19/263 (7%)
Query: 846 KRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQDQPPGDNARSQV 905
K+ +L + R SE+ + LK K + L +++ N Q++ + +
Sbjct: 187 KKNAELQEKLRLAESEKSEIQLNV-KELKRKLERAKFLLPQVQTNTLQEEMW---RQEEE 242
Query: 906 LREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQ------KAKELARI 959
LRE+ ++ + EK + L + + EK+R++ +Q + KEL
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQ 302
Query: 960 EEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSS 1019
++ +++E + ++E K++E+ +++ E++ ++++ + + ++ +E K
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEEKM------REQEEKMWRQEERLWEQEKQMREQEQKMRD 356
Query: 1020 THSRLRSQIQMLVRENTDLREEIKVMER-FRLDAWKRAEAIESSLEVEKKDKLANTSVRF 1078
R+ Q + L + +RE+ K+ E+ ++ +R E + E+++ + +
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMR-EEEETMREQEEKM 415
Query: 1079 QNSQISSGTQVEK-YKKNYLPMQ 1100
Q + + Q EK +++ LP Q
Sbjct: 416 QKQEENMWEQEEKEWQQQRLPEQ 438
Score = 38.5 bits (88), Expect = 0.044
Identities = 83/484 (17%), Positives = 186/484 (38%), Gaps = 66/484 (13%)
Query: 544 ETMKESESSLDVSLQKKLETWEREKE----KENLELDEFLFLEQAADEISFSSNSSFVLK 599
E M+E E + +++ WE+EK+ ++ + E EQ K
Sbjct: 324 EKMREQEEKM---WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 380
Query: 600 ILERDQQICKGHRMSSTPVKAVPQKTNPADPISHCNRSEDLDHTAREKESECEVAPKQLH 659
+ E+++++ + R+ K ++ + + E+ EKE + + P+Q
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 660 SLSSADELREQPCKIRKAVQKSTSENQTEWNA-----RDDEGVPNSDSSTDSEEQLDVTI 714
L ++++EQ KI + +K + + W R ++ D + EE++
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEM-WGQEKKMWRQEKMREQEDQMWEQEEKM---- 495
Query: 715 KPSTEDRERGISSREDSPQVCDDKGPFKDTRTQEDKRRDVDLDLSDKDYSSDESIMESIK 774
D+E+ + +E+ D++ K+ R +E K K + +E + E K
Sbjct: 496 ----RDQEQKMWDQEERMWEQDERLREKEERMREQK----------KMWQQEEKMREEKK 541
Query: 775 HKVSEPSRSSSLSLSKMDFDDERTWTDLEENLCNHDVVLGNESTYGTPQTCYPNNEIGIL 834
+ E ++TW D EE + + + E + E +
Sbjct: 542 TQEQE----------------KKTW-DQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584
Query: 835 DKTIKRKIAPVKRGEDLSKSRRSRSPPTSELMMKFFPSLKPKPKSDSHLGNELKLNISQD 894
++ K + K E K + E M + + + + D K+ ++
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQ-----EEKMWEQEEKMWEQEEED-------KMQEQEE 632
Query: 895 QPPGDNARSQVLREKIIELETEIEKFKAENASLAKLRIERESALEKLRKEIADFEQQKAK 954
+ Q EK+ E E EK + + + + + + EK+R++ + Q+ K
Sbjct: 633 MMWEQEEKMQEQEEKMWEQE---EKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 955 ELARIEEFKKEEMRKLQKERKVFEKYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKE 1014
+ E+ + +E + +E K++ + + + ++ RE+ + ++ Q ++E L E
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQ---EEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Query: 1015 TKWS 1018
+ S
Sbjct: 747 ERCS 750
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.357
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,162,048
Number of Sequences: 37866
Number of extensions: 2758436
Number of successful extensions: 20078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 1057
Number of HSP's that attempted gapping in prelim test: 12264
Number of HSP's gapped (non-prelim): 6662
length of query: 1338
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1224
effective length of database: 13,930,794
effective search space: 17051291856
effective search space used: 17051291856
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.