Search of human proteins with 12962937

Search of human proteins with 12962937

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|12962937 achalasia, adrenocortical insufficiency, alacrimia
(Allgrove, triple-A) [Homo sapiens]
         (546 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|12962937 achalasia, adrenocortical insufficiency, alacrimia (...  1149   0.0  
gi|4757988 WD repeat domain 39 [Homo sapiens]                          51   2e-06
gi|14150171 THO complex 3 [Homo sapiens]                               51   3e-06
gi|19913369 transducin beta-like 3 [Homo sapiens]                      48   2e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            47   4e-05
gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]               46   8e-05
gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]               46   8e-05
gi|21536485 HIR histone cell cycle regulation defective homolog ...    45   2e-04
gi|124028512 WD40-repeat protein upregulated in HCC isoform b [H...    45   2e-04
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa...    45   2e-04
gi|124028510 WD40-repeat protein upregulated in HCC isoform c [H...    44   3e-04
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      44   5e-04
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    44   5e-04
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             43   6e-04
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     43   6e-04
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]       43   8e-04
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               42   0.001
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               42   0.001
gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform ...    42   0.001
gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1...    42   0.001
gi|46409657 WD repeat domain 56 [Homo sapiens]                         42   0.001
gi|16554629 WD repeat domain 5 [Homo sapiens]                          42   0.001
gi|16554627 WD repeat domain 5 [Homo sapiens]                          42   0.001
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          42   0.001
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          42   0.001
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          42   0.001
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            42   0.001
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]           42   0.002
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    41   0.002
gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]          41   0.002

>gi|12962937 achalasia, adrenocortical insufficiency, alacrimia
           (Allgrove, triple-A) [Homo sapiens]
          Length = 546

 Score = 1149 bits (2973), Expect = 0.0
 Identities = 546/546 (100%), Positives = 546/546 (100%)

Query: 1   MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR 60
           MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR
Sbjct: 1   MCSLGLFPPPPPRGQVTLYEHNNELVTGSSYESPPPDFRGQWINLPVLQLTKDPLKTPGR 60

Query: 61  LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW 120
           LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW
Sbjct: 61  LDHGTRTAFIHHREQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRW 120

Query: 121 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA 180
           ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA
Sbjct: 121 ASSLHGSLFPHLSLRSEDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNA 180

Query: 181 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS 240
           SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS
Sbjct: 181 SSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLS 240

Query: 241 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS 300
           HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS
Sbjct: 241 HPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS 300

Query: 301 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE 360
           KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE
Sbjct: 301 KILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPE 360

Query: 361 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR 420
           RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR
Sbjct: 361 RCGEGKGCVGGAKSATIVADLSETTIQTPDGEERLGGEAHSMVWDPSGERLAVLMKGKPR 420

Query: 421 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA 480
           VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA
Sbjct: 421 VQDGKPVILLFRTRNSPVFELLPCGIIQGEPGAQPQLITFHPSFNKGALLSVGWSTGRIA 480

Query: 481 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH 540
           HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH
Sbjct: 481 HIPLYFVNAQFPRFSPVLGRAQEPPAGGGGSIHDLPLFTETSPTSAPWDPLPGPPPVLPH 540

Query: 541 SPHSHL 546
           SPHSHL
Sbjct: 541 SPHSHL 546


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 54/199 (27%), Positives = 81/199 (40%), Gaps = 25/199 (12%)

Query: 158 AWHPHTNKFAVALLDDSVRVYNAS--STIVPS-LKHRLQRNVASLAWKPLSASVLAVACQ 214
           AW+P     A    D  +R++     S I  S L    QR V  +AW P    + + +  
Sbjct: 23  AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82

Query: 215 SCILIWTLDPTSLSTRPSSGCAQVLSHPGH-TPVTSLAWAPSGGRLLSASPVDAAIRVWD 273
           +   IW  +           C   L   GH   V S+AWAPS G LL+    D ++ VW+
Sbjct: 83  ATTCIWKKNQDDFE------CVTTLE--GHENEVKSVAWAPS-GNLLATCSRDKSVWVWE 133

Query: 274 VSTE---TCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVW--EAQMWTCERWPTLS 328
           V  E    CV +       V +++W P    + + +     +++  E   W C    TL 
Sbjct: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC--CATLE 191

Query: 329 GRCQTGCWS----PDGSRL 343
           G  ++  WS    P G RL
Sbjct: 192 GH-ESTVWSLAFDPSGQRL 209



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 33/119 (27%), Positives = 47/119 (39%), Gaps = 9/119 (7%)

Query: 199 LAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGR 258
           LAW P    + +      I IW  +  S        C  VLS      V  +AW+P G  
Sbjct: 22  LAWNPAGTLLASCGGDRRIRIWGTEGDSWI------CKSVLSEGHQRTVRKVAWSPCGNY 75

Query: 259 LLSASPVDAAIRVWDVSTE--TCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
           L SAS  DA   +W  + +   CV         V ++ W+P G+ +   +      VWE
Sbjct: 76  LASAS-FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 42/182 (23%), Positives = 72/182 (39%), Gaps = 15/182 (8%)

Query: 154 LRVFAWHPHTNKFAVALLDDSVRVYNASST---IVPSLKHRLQRNVASLAWKPLSASVLA 210
           +R  AW P  N  A A  D +  ++  +      V +L+   +  V S+AW P    +  
Sbjct: 64  VRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGH-ENEVKSVAWAPSGNLLAT 122

Query: 211 VACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWAPSGGRLLSASPVDAAI 269
            +    + +W +D           C  VL+   HT  V  + W PS   L SAS  D  +
Sbjct: 123 CSRDKSVWVWEVDEED-----EYECVSVLN--SHTQDVKHVVWHPSQELLASAS-YDDTV 174

Query: 270 RVWDVSTETCVPLPWFRG--GGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTL 327
           +++    +  V      G    V +L + P G ++ + +     R+W   +   E+    
Sbjct: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVAC 234

Query: 328 SG 329
           SG
Sbjct: 235 SG 236



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 27/100 (27%), Positives = 45/100 (45%), Gaps = 7/100 (7%)

Query: 250 LAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGG---VTNLLWSPDGSKILATT 306
           LAW P+G  LL++   D  IR+W    ++ +       G    V  + WSP G+ + + +
Sbjct: 22  LAWNPAG-TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80

Query: 307 PSAVFRVWEAQMWTCERWPTLSG---RCQTGCWSPDGSRL 343
             A   +W+      E   TL G     ++  W+P G+ L
Sbjct: 81  FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLL 120



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 57/259 (22%), Positives = 88/259 (33%), Gaps = 28/259 (10%)

Query: 73  REQVWKRCINIWRDVGLFGVLNEIANSEEEVFEWVKTASGWALALCRWASSLHGSLFPHL 132
           R+  W  C N       F     I    ++ FE V T  G    +   A +  G+L    
Sbjct: 65  RKVAWSPCGNYLASAS-FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATC 123

Query: 133 SLRS--------EDLIAEFAQVTNWSSCCLRVFAWHPHTNKFAVALLDDSVRVYNASST- 183
           S           E+   E   V N  +  ++   WHP     A A  DD+V++Y      
Sbjct: 124 SRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDD 183

Query: 184 -IVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIW-------TLDPTSLSTRPSSGC 235
            +  +     +  V SLA+ P    + + +    + IW               + PS  C
Sbjct: 184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKC 243

Query: 236 AQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWF---------R 286
              LS      +  +AW    G L +A   D AIRV+     +    P F          
Sbjct: 244 ICTLSGFHSRTIYDIAWCQLTGALATACG-DDAIRVFQEDPNSDPQQPTFSLTAHLHQAH 302

Query: 287 GGGVTNLLWSPDGSKILAT 305
              V  + W+P    +LA+
Sbjct: 303 SQDVNCVAWNPKEPGLLAS 321



 Score = 33.1 bits (74), Expect = 0.67
 Identities = 18/79 (22%), Positives = 31/79 (39%)

Query: 194 RNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWA 253
           R +  +AW  L+ ++        I ++  DP S   +P+      L       V  +AW 
Sbjct: 253 RTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWN 312

Query: 254 PSGGRLLSASPVDAAIRVW 272
           P    LL++   D  +  W
Sbjct: 313 PKEPGLLASCSDDGEVAFW 331


>gi|14150171 THO complex 3 [Homo sapiens]
          Length = 351

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 35/122 (28%), Positives = 50/122 (40%), Gaps = 3/122 (2%)

Query: 240 SHPGH-TPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPD 298
           ++ GH   V  L W PS   L   +  D  IR+WDV T  C+     +G  + N+ WSPD
Sbjct: 94  NYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSPD 152

Query: 299 GSKILATTPSAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSF 358
           G  I       V    +A+    +             W+ D + + F   G   I  LS+
Sbjct: 153 GQTIAVGNKDDVVTFIDAKTHRSKAEEQFKFEVNEISWNND-NNMFFLTNGNGCINILSY 211

Query: 359 PE 360
           PE
Sbjct: 212 PE 213



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 54/230 (23%), Positives = 84/230 (36%), Gaps = 55/230 (23%)

Query: 159 WHP-HTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCI 217
           WHP + + F  A  D ++R+++  +T   +  +    N+ ++ W P     +AV  +  +
Sbjct: 107 WHPSNPDLFVTASGDKTIRIWDVRTTKCIATVNTKGENI-NICWSP-DGQTIAVGNKDDV 164

Query: 218 LI-----------------------WTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAP 254
           +                        W  D         +GC  +LS+P   PV S+   P
Sbjct: 165 VTFIDAKTHRSKAEEQFKFEVNEISWNNDNNMFFLTNGNGCINILSYPELKPVQSINAHP 224

Query: 255 SG---------GRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILAT 305
           S          G+  +    DA + +WDV    CV         V  L +S DG K+LA+
Sbjct: 225 SNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRCFSRLDWPVRTLSFSHDG-KMLAS 283

Query: 306 TPSAVF----------RVWEAQMWTCERWPTLSGRCQTGCWSPDGSRLLF 345
                F          ++WE Q   CE  PT      T  W P    L F
Sbjct: 284 ASEDHFIDIAEVETGDKLWEVQ---CES-PTF-----TVAWHPKRPLLAF 324


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 33/125 (26%), Positives = 58/125 (46%), Gaps = 14/125 (11%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTL--DPTSLSTRPSSGCAQVLS-HPGHTPVTSLAW 252
           VA++A+ P S  +    C   + +W +     +   R S G   +++ HP  T +     
Sbjct: 112 VATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRL----- 166

Query: 253 APSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFR 312
                 LL +S  DAAIRVW +   +C+ +       VT+L +S DG  +L++    +  
Sbjct: 167 ------LLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220

Query: 313 VWEAQ 317
           +W+ Q
Sbjct: 221 IWDLQ 225


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 17/165 (10%)

Query: 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRN-VASLAWKPLSASVLAVACQSC 216
           A+ P     A    D +VR ++ S T  P    +  R+ V S++W P    + +      
Sbjct: 121 AFSPTGKYLASGSGDTTVRFWDLS-TETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQ 179

Query: 217 ILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWAPSGG----RLLSASPVDAAIRV 271
           IL+W          PS+G     +  GH+  +T L+W P       R +++S  D ++R+
Sbjct: 180 ILLWD---------PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230

Query: 272 WDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
           WD +   C  +       VT L W  DG  + + +     +VW A
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRA 274



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/78 (37%), Positives = 43/78 (55%), Gaps = 10/78 (12%)

Query: 243 GHTP-VTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGG----VTNLLWSP 297
           GH+  V S+A++P+G  L S S  D  +R WD+STET    P F   G    V ++ WSP
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSG-DTTVRFWDLSTET----PHFTCKGHRHWVLSISWSP 166

Query: 298 DGSKILATTPSAVFRVWE 315
           DG K+ +   +    +W+
Sbjct: 167 DGRKLASGCKNGQILLWD 184



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 23/74 (31%), Positives = 37/74 (50%), Gaps = 4/74 (5%)

Query: 243 GHTP-VTSLAWAPSGGRLLSASPVDAAIRVWDVSTET-CVPLPWFRGGGVTNLLWSPDGS 300
           GH   V  +AW+ +  RLL +   D+ ++VWDV  +   + LP      V  + WSPDG 
Sbjct: 412 GHVAAVYQIAWS-ADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG-HADEVYAVDWSPDGQ 469

Query: 301 KILATTPSAVFRVW 314
           ++ +       R+W
Sbjct: 470 RVASGGKDKCLRIW 483



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 38/155 (24%), Positives = 62/155 (40%), Gaps = 23/155 (14%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWAP 254
           V S+A+ P    + + +  + +  W L   +    P   C       GH   V S++W+P
Sbjct: 117 VISVAFSPTGKYLASGSGDTTVRFWDLSTET----PHFTCK------GHRHWVLSISWSP 166

Query: 255 SGGRLLSASPVDAAIRVWDVSTETCVPLP------WFRGGGVTNLLWSPDGSKILATTPS 308
            G +L S    +  I +WD ST   V         W  G     L  +P+   + +++  
Sbjct: 167 DGRKLASGCK-NGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225

Query: 309 AVFRVWEAQMWTCERWPTLSGRCQTGC---WSPDG 340
              R+W+     CER   L+G  Q+     W  DG
Sbjct: 226 GSVRIWDTTAGRCER--ILTGHTQSVTCLRWGGDG 258



 Score = 35.8 bits (81), Expect = 0.10
 Identities = 23/103 (22%), Positives = 45/103 (43%), Gaps = 3/103 (2%)

Query: 243 GHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKI 302
           GH  + +        R+++++  D +I++WD  T   +         V  + WS D   +
Sbjct: 370 GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLL 429

Query: 303 LATTPSAVFRVWE--AQMWTCERWPTLSGRCQTGCWSPDGSRL 343
           ++ +  +  +VW+  AQ    +  P  +       WSPDG R+
Sbjct: 430 VSGSSDSTLKVWDVKAQKLAMD-LPGHADEVYAVDWSPDGQRV 471


>gi|59938780 WD repeat domain 31 isoform 1 [Homo sapiens]
          Length = 367

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 9/146 (6%)

Query: 172 DDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRP 231
           D +V  YN  +  V       +  +  +A  P S+   + +    +++W L  +S   + 
Sbjct: 82  DKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQ 141

Query: 232 SSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
             G A V        VT LA +P   +L + S  D  + +WDV T   V         VT
Sbjct: 142 LCGHAMV--------VTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRNVVT 192

Query: 292 NLLWSPDGSKILATTPSAVFRVWEAQ 317
           +L W P    IL T+     R+W+++
Sbjct: 193 HLCWVPREPYILQTSEDKTLRLWDSR 218


>gi|21687048 WD repeat domain 31 isoform 3 [Homo sapiens]
          Length = 366

 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 9/146 (6%)

Query: 172 DDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRP 231
           D +V  YN  +  V       +  +  +A  P S+   + +    +++W L  +S   + 
Sbjct: 81  DKTVVAYNWKTGNVVKRFKGHEHEITKVACIPKSSQFFSASRDRMVMMWDLHGSSQPRQQ 140

Query: 232 SSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
             G A V        VT LA +P   +L + S  D  + +WDV T   V         VT
Sbjct: 141 LCGHAMV--------VTGLAVSPDSSQLCTGSR-DNTLLLWDVVTGQSVERASVSRNVVT 191

Query: 292 NLLWSPDGSKILATTPSAVFRVWEAQ 317
           +L W P    IL T+     R+W+++
Sbjct: 192 HLCWVPREPYILQTSEDKTLRLWDSR 217


>gi|21536485 HIR histone cell cycle regulation defective homolog A
           [Homo sapiens]
          Length = 1017

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/155 (23%), Positives = 66/155 (42%), Gaps = 15/155 (9%)

Query: 156 VFAWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQS 215
           +  W   T      +   S ++ N       S+      +V  +AW P  A + + +  +
Sbjct: 94  IMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDN 153

Query: 216 CILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVW--- 272
            ++IW       + +     A +  H G   V  L W P  G+ +++   D +++VW   
Sbjct: 154 TVVIWN------AVKFPEILATLRGHSG--LVKGLTWDPV-GKYIASQADDRSLKVWRTL 204

Query: 273 DVSTETCVPLPWFRGGGVTNLL---WSPDGSKILA 304
           D   ET +  P+   GG T++L   WSPDG  +++
Sbjct: 205 DWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 16/112 (14%)

Query: 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRN---VASLAWKPLSASVLAVACQ 214
           AW PH    A   +D++V ++NA     P +   L+ +   V  L W P+   + + A  
Sbjct: 138 AWSPHDAWLASCSVDNTVVIWNAVK--FPEILATLRGHSGLVKGLTWDPVGKYIASQADD 195

Query: 215 SCILIW-TLD---PTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSA 262
             + +W TLD    TS+ T+P   C       G T V  L+W+P G  L+SA
Sbjct: 196 RSLKVWRTLDWQLETSI-TKPFDECG------GTTHVLRLSWSPDGHYLVSA 240



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 35/120 (29%), Positives = 47/120 (39%), Gaps = 14/120 (11%)

Query: 235 CAQVL-SHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRG--GGVT 291
           C  +L +H G   V  +AW+P    L S S VD  + +W+      + L   RG  G V 
Sbjct: 123 CVSILRNHSGD--VMDVAWSPHDAWLASCS-VDNTVVIWNAVKFPEI-LATLRGHSGLVK 178

Query: 292 NLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTL-------SGRCQTGCWSPDGSRLL 344
            L W P G  I +       +VW    W  E   T        +       WSPDG  L+
Sbjct: 179 GLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLV 238


>gi|124028512 WD40-repeat protein upregulated in HCC isoform b [Homo
           sapiens]
          Length = 620

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 35/134 (26%), Positives = 59/134 (44%), Gaps = 16/134 (11%)

Query: 205 SASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLS-AS 263
           S  V  +  ++ I++W      L  R S        H G   + +LA++P+   L+S   
Sbjct: 81  SGQVTFMGFKADIILWDYKNRELLARLSL-------HKGK--IEALAFSPNDLYLVSLGG 131

Query: 264 PVDAAIRVWDVSTETCV---PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWT 320
           P D ++ VW ++    +   P      G  TN+++S    ++  T  +   RVWE  +  
Sbjct: 132 PDDGSVVVWSIAKRDAICGSPAAGLNVGNATNVIFSRCRDEMFMTAGNGTIRVWELDLPN 191

Query: 321 CERWPTLSGRCQTG 334
            + WPT    CQTG
Sbjct: 192 RKIWPT---ECQTG 202


>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
           sapiens]
          Length = 474

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 33/126 (26%), Positives = 57/126 (45%), Gaps = 16/126 (12%)

Query: 196 VASLAWKPLSASVLAVACQSC-ILIWTLDPTSLSTRPSSGCAQVLSHP-----GHTP-VT 248
           V  + W P +  V+A   + C +++W +        P +G    L+ P     GH+  V 
Sbjct: 83  VLDIDWCPHNDQVIASGSEDCTVMVWQI--------PENGLTLSLTEPVVILEGHSKRVG 134

Query: 249 SLAWAPSGGRLLSASPVDAAIRVWDVST-ETCVPLPWFRGGGVTNLLWSPDGSKILATTP 307
            +AW P+   +L ++  D AI +W+V T E  + L       + N+ W+ +GS I   + 
Sbjct: 135 IVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASK 194

Query: 308 SAVFRV 313
               RV
Sbjct: 195 DKKVRV 200


>gi|124028510 WD40-repeat protein upregulated in HCC isoform c [Homo
           sapiens]
          Length = 552

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 9/103 (8%)

Query: 236 AQVLSHPGHTPVTSLAWAPSGGRLLS-ASPVDAAIRVWDVSTETCV---PLPWFRGGGVT 291
           A++  H G   + +LA++P+   L+S   P D ++ VW ++    +   P      G  T
Sbjct: 37  ARLSLHKGK--IEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGNAT 94

Query: 292 NLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTLSGRCQTG 334
           N+++S    ++  T  +   RVWE  +   + WPT    CQTG
Sbjct: 95  NVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPT---ECQTG 134


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 16/130 (12%)

Query: 198 SLAWKP-LSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHP--GHT-PVTSLAWA 253
           +L W P ++  +L   CQ  I +WT  PT        G   V   P  GHT  V  L W+
Sbjct: 219 ALDWSPRVTGRLLTGDCQKNIHLWT--PTD------GGSWHVDQRPFVGHTRSVEDLQWS 270

Query: 254 PSGGRLLSASPVDAAIRVWDV----STETCVPLPWFRGGGVTNLLWSPDGSKILATTPSA 309
           P+   + ++   DA+IR+WD+    S    +       G V  + WS     +L+     
Sbjct: 271 PTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDG 330

Query: 310 VFRVWEAQMW 319
             ++W+ + +
Sbjct: 331 ALKIWDLRQF 340



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 33/127 (25%), Positives = 50/127 (39%), Gaps = 17/127 (13%)

Query: 159 WHPHTNK-FAVALLDDSVRVYNASST------IVPSLKHRLQRNVASLAWKPLSASVLAV 211
           W P  N  FA    D S+R+++  +       +  +  H    NV S  W      +L+ 
Sbjct: 269 WSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVIS--WSRREPFLLSG 326

Query: 212 ACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIR 270
                + IW L       R     + V +   H  PVTS+ W P    + +AS  D  I 
Sbjct: 327 GDDGALKIWDL-------RQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADHQIT 379

Query: 271 VWDVSTE 277
            WD++ E
Sbjct: 380 QWDLAVE 386


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 51/183 (27%), Positives = 76/183 (41%), Gaps = 35/183 (19%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWAP 254
           V ++ +   S  +++    + I +W L    L+           +  GH   VT L+ + 
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLT----------YTMRGHADSVTGLSLSS 245

Query: 255 SGGRLLSASPVDAAIRVWDVST----ETCVPLPWFRGGGVT---NLL---WSPDGSKILA 304
            G  LLS + +D  +RVWDV      E CV +  F+G       NLL   WSPDGSKI A
Sbjct: 246 EGSYLLS-NAMDNTVRVWDVRPFAPKERCVKI--FQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 305 TTPSAVFRVWE-AQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLIYSLSFPERCG 363
            +      VW+        + P  +G      + PD          EP+I S S  +R  
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD----------EPIIISASSDKRLY 352

Query: 364 EGK 366
            G+
Sbjct: 353 MGE 355



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 7/103 (6%)

Query: 230 RPSSGCAQVLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRG- 287
           R SS  A ++   GH   V    + P+G  L SA   D  I +W+V  + C      +G 
Sbjct: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAG-FDRLILLWNVYGD-CDNYATLKGH 108

Query: 288 -GGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTCERWPTLSG 329
            G V  L ++ DGS + + +      VW+++  T ER   L G
Sbjct: 109 SGAVMELHYNTDGSMLFSASTDKTVAVWDSE--TGERVKRLKG 149


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 58/226 (25%), Positives = 89/226 (39%), Gaps = 34/226 (15%)

Query: 238  VLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE---TCVPLPWFRGGGVTNLL 294
            +L H G  PV + A + + G +L+AS  D ++R+W V  E   TC+P        VT + 
Sbjct: 2234 LLGHSG--PVRAAAVSETSGLMLTASE-DGSVRLWQVPKEADDTCIPRS---SAAVTAVA 2287

Query: 295  WSPDGSKILATTPSAVFRVW-EAQMWTCERWPTLSGRCQTGCWSPDGSRLLFTVLGEPLI 353
            W+PDGS  ++   +    +W EA+     + P   G      WS   +   F +  +  I
Sbjct: 2288 WAPDGSMAVSGNQAGELILWQEAKAVATAQAP---GHIGALIWS--SAHTFFVLSADEKI 2342

Query: 354  YSLSFPERCGEGKGCVGGAKSATIVADLSETTI--QTPDGEERL------------GGEA 399
                   R G   G +    +  +  DL   T     PDG   +             G+A
Sbjct: 2343 SEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPGDA 2402

Query: 400  HSMVWDPSGERLAVLMKGKPR----VQDGKPVILLF-RTRNSPVFE 440
             S +W    E   +L   K      +Q   P +L F R + S  FE
Sbjct: 2403 PSEIWSSYTENPMILSTHKEYGIFVLQPKDPGVLSFLRQKESGEFE 2448



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 50/207 (24%), Positives = 76/207 (36%), Gaps = 51/207 (24%)

Query: 158  AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCI 217
            A  P  ++ AV    D +R+Y  SS    +    L   V++LAW  LS  VL    +   
Sbjct: 1934 ALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAW--LSPKVLVSGAEDGS 1991

Query: 218  LI-WTLDPTSLST--------RPSSGCA--------------------QVLSHP------ 242
            L  W L   SL +        +P  G A                    Q+L+ P      
Sbjct: 1992 LQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDF 2051

Query: 243  -------GHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPL----PWFRGGGV 290
                   GH  PV+  +++  GG L +    D ++  WDV T     L    P      V
Sbjct: 2052 PCGTELRGHEGPVSCCSFSTDGGSLATGGR-DRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110

Query: 291  TNLLWSPDGSKILATTPSAVFRVWEAQ 317
            T   W+ D   I  ++  +V  +W+ +
Sbjct: 2111 TGCAWTKDNLLISCSSDGSV-GLWDPE 2136


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 37/161 (22%), Positives = 69/161 (42%), Gaps = 10/161 (6%)

Query: 161 PHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIW 220
           P++  FA    D + R+++   T    +      +V  + + P S  +   +    + +W
Sbjct: 394 PYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453

Query: 221 TLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCV 280
                  S +  +       H G  PV SLA++P+G  L SA   D  +++WD+++ T  
Sbjct: 454 -------SAQQGNSVRLFTGHRG--PVLSLAFSPNGKYLASAGE-DQRLKLWDLASGTLY 503

Query: 281 PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC 321
                    +T+L +SPD   I + +     RVW+ +   C
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 40/171 (23%), Positives = 68/171 (39%), Gaps = 18/171 (10%)

Query: 147 TNW-SSCCLRVFAWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLS 205
           T+W S CC     +HP  +K A +  D +V++++              R V S  W    
Sbjct: 394 TDWLSDCC-----FHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCG 448

Query: 206 ASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWAPSGGRLLSASP 264
             V + +      IW ++        S  C   L   GHT  V S+ + P    LL++S 
Sbjct: 449 NFVASSSLDKTSKIWDVN--------SERCRCTLY--GHTDSVNSIEFFPFSNTLLTSS- 497

Query: 265 VDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWE 315
            D  + +WD  T  C    +     + + ++ P G  I +     V ++W+
Sbjct: 498 ADKTLSIWDARTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWD 548



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 22/87 (25%), Positives = 45/87 (51%), Gaps = 2/87 (2%)

Query: 238 VLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWS 296
           +L+  GH+  V S  W  S G  +++S +D   ++WDV++E C    +     V ++ + 
Sbjct: 429 ILTFEGHSRAVWSCTWH-SCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFF 487

Query: 297 PDGSKILATTPSAVFRVWEAQMWTCER 323
           P  + +L ++      +W+A+   CE+
Sbjct: 488 PFSNTLLTSSADKTLSIWDARTGICEQ 514



 Score = 34.3 bits (77), Expect = 0.30
 Identities = 19/88 (21%), Positives = 41/88 (46%), Gaps = 2/88 (2%)

Query: 235 CAQVLSHPGHTP-VTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNL 293
           C  +L+  GHT  ++   + PSG +L ++S  D  +++WD+    C+         V + 
Sbjct: 384 CNVLLTGFGHTDWLSDCCFHPSGDKLATSSG-DTTVKLWDLCKGDCILTFEGHSRAVWSC 442

Query: 294 LWSPDGSKILATTPSAVFRVWEAQMWTC 321
            W   G+ + +++     ++W+     C
Sbjct: 443 TWHSCGNFVASSSLDKTSKIWDVNSERC 470


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/150 (27%), Positives = 59/150 (39%), Gaps = 19/150 (12%)

Query: 172 DDSVRVYNASSTIVPSLK----HRLQRNVASLAWKPLSASVLAVACQS-CILIWTLDPTS 226
           D +VRVY  +++    LK    H  +  V  + W PL   +L        + IW      
Sbjct: 519 DTNVRVYYVATSSDQPLKVFSGHTAK--VFHVKWSPLREGILCSGSDDGTVRIWDYT--- 573

Query: 227 LSTRPSSGCAQVLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWF 285
                   C  +L+  GHT PV  L W      LL +   D  I+VWD    TCV   + 
Sbjct: 574 -----QDACINILN--GHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 626

Query: 286 RGGGVTNLLWSPDGSKILAT-TPSAVFRVW 314
            G  V  L   P     +A+ +  +  R+W
Sbjct: 627 HGADVYGLTCHPSRPFTMASCSRDSTVRLW 656



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 3/66 (4%)

Query: 254 PSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILA--TTPSAVF 311
           P    LL+ +  D  I+VWD++T T V       G + +L W+P G   +A  T+ +  F
Sbjct: 379 PDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAF 438

Query: 312 RVWEAQ 317
            +W  Q
Sbjct: 439 -IWNVQ 443



 Score = 30.4 bits (67), Expect = 4.3
 Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 3/73 (4%)

Query: 252 WAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRG--GGVTNLLWSPDGSKILAT-TPS 308
           W+ +   +++    D  +RV+ V+T +  PL  F G    V ++ WSP    IL + +  
Sbjct: 505 WSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDD 564

Query: 309 AVFRVWEAQMWTC 321
              R+W+     C
Sbjct: 565 GTVRIWDYTQDAC 577



 Score = 29.6 bits (65), Expect = 7.4
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 13/114 (11%)

Query: 201 WKPLSASVLAVAC-QSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVT-SLAWAPSGGR 258
           +KP   ++LA A     I +W ++  +           V + PG+  V  SL+WAP G  
Sbjct: 377 FKPDDPNLLATASFDGTIKVWDINTLTA----------VYTSPGNEGVIYSLSWAPGGLN 426

Query: 259 LLSASPVDAAIRVWDVSTETCVPLPWFRG-GGVTNLLWSPDGSKILATTPSAVF 311
            ++         +W+V     +      G  G+  + WS   SK +AT  S  F
Sbjct: 427 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 480


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/150 (27%), Positives = 59/150 (39%), Gaps = 19/150 (12%)

Query: 172 DDSVRVYNASSTIVPSLK----HRLQRNVASLAWKPLSASVLAVACQS-CILIWTLDPTS 226
           D +VRVY  +++    LK    H  +  V  + W PL   +L        + IW      
Sbjct: 543 DTNVRVYYVATSSDQPLKVFSGHTAK--VFHVKWSPLREGILCSGSDDGTVRIWDYT--- 597

Query: 227 LSTRPSSGCAQVLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWF 285
                   C  +L+  GHT PV  L W      LL +   D  I+VWD    TCV   + 
Sbjct: 598 -----QDACINILN--GHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD 650

Query: 286 RGGGVTNLLWSPDGSKILAT-TPSAVFRVW 314
            G  V  L   P     +A+ +  +  R+W
Sbjct: 651 HGADVYGLTCHPSRPFTMASCSRDSTVRLW 680



 Score = 37.4 bits (85), Expect = 0.036
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 3/66 (4%)

Query: 254 PSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILA--TTPSAVF 311
           P    LL+ +  D  I+VWD++T T V       G + +L W+P G   +A  T+ +  F
Sbjct: 403 PDDPNLLATASFDGTIKVWDINTLTAVYTSPGNEGVIYSLSWAPGGLNCIAGGTSRNGAF 462

Query: 312 RVWEAQ 317
            +W  Q
Sbjct: 463 -IWNVQ 467



 Score = 30.4 bits (67), Expect = 4.3
 Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 3/73 (4%)

Query: 252 WAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRG--GGVTNLLWSPDGSKILAT-TPS 308
           W+ +   +++    D  +RV+ V+T +  PL  F G    V ++ WSP    IL + +  
Sbjct: 529 WSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDD 588

Query: 309 AVFRVWEAQMWTC 321
              R+W+     C
Sbjct: 589 GTVRIWDYTQDAC 601



 Score = 29.6 bits (65), Expect = 7.4
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 13/114 (11%)

Query: 201 WKPLSASVLAVAC-QSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVT-SLAWAPSGGR 258
           +KP   ++LA A     I +W ++  +           V + PG+  V  SL+WAP G  
Sbjct: 401 FKPDDPNLLATASFDGTIKVWDINTLTA----------VYTSPGNEGVIYSLSWAPGGLN 450

Query: 259 LLSASPVDAAIRVWDVSTETCVPLPWFRG-GGVTNLLWSPDGSKILATTPSAVF 311
            ++         +W+V     +      G  G+  + WS   SK +AT  S  F
Sbjct: 451 CIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGF 504


>gi|56550086 WD repeat and HMG-box DNA binding protein 1 isoform 2
           [Homo sapiens]
          Length = 1006

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 19/149 (12%)

Query: 167 AVALLDDSVRVYNASSTIVPSLKHRLQR--------NVASLAWKPLSASVLAVACQSCIL 218
           A A  D SVRV+  S          LQ+        ++  LAW+P S  +LA+  +  + 
Sbjct: 29  ASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVK 88

Query: 219 IWTLDPTSLSTRPSSG-CAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE 277
           ++  +  S     S    +Q L+         + W+P  G+ L+A  ++  I VW+V T+
Sbjct: 89  LYRRESWSHQFDLSDNFISQTLN--------IVTWSPC-GQYLAAGSINGLIIVWNVETK 139

Query: 278 TCVP-LPWFRGGGVTNLLWSPDGSKILAT 305
            C+  +   +G  +  L W P   +I  T
Sbjct: 140 DCMERVKHEKGYAICGLAWHPTCGRISYT 168



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 12/88 (13%)

Query: 243 GH-TPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPW---------FRGGGVTN 292
           GH  PV SL++ P    L SAS  D ++RVW +S +TC  + W              +  
Sbjct: 11  GHDAPVLSLSFDPKDIFLASAS-CDGSVRVWQISDQTCA-ISWPLLQKCNDVINAKSICR 68

Query: 293 LLWSPDGSKILATTPSAVFRVWEAQMWT 320
           L W P   K+LA       +++  + W+
Sbjct: 69  LAWQPKSGKLLAIPVEKSVKLYRRESWS 96



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/164 (24%), Positives = 69/164 (42%), Gaps = 24/164 (14%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTL-DPTSLSTRPS-SGCAQVLSHPGHTPVTSLAWA 253
           V SL++ P    + + +C   + +W + D T   + P    C  V++      +  LAW 
Sbjct: 16  VLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKS---ICRLAWQ 72

Query: 254 PSGGRLLSASPVDAAIRVW---------DVSTETCVPLPWFRGGGVTNLLWSPDGSKILA 304
           P  G+LL A PV+ +++++         D+S         F    +  + WSP G  + A
Sbjct: 73  PKSGKLL-AIPVEKSVKLYRRESWSHQFDLSDN-------FISQTLNIVTWSPCGQYLAA 124

Query: 305 TTPSAVFRVWEAQMWTC-ERWPTLSGRCQTG-CWSPDGSRLLFT 346
            + + +  VW  +   C ER     G    G  W P   R+ +T
Sbjct: 125 GSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYT 168


>gi|5901892 WD repeat and HMG-box DNA binding protein 1 isoform 1
           [Homo sapiens]
          Length = 1129

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 19/149 (12%)

Query: 167 AVALLDDSVRVYNASSTIVPSLKHRLQR--------NVASLAWKPLSASVLAVACQSCIL 218
           A A  D SVRV+  S          LQ+        ++  LAW+P S  +LA+  +  + 
Sbjct: 152 ASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVK 211

Query: 219 IWTLDPTSLSTRPSSG-CAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE 277
           ++  +  S     S    +Q L+         + W+P  G+ L+A  ++  I VW+V T+
Sbjct: 212 LYRRESWSHQFDLSDNFISQTLN--------IVTWSPC-GQYLAAGSINGLIIVWNVETK 262

Query: 278 TCVP-LPWFRGGGVTNLLWSPDGSKILAT 305
            C+  +   +G  +  L W P   +I  T
Sbjct: 263 DCMERVKHEKGYAICGLAWHPTCGRISYT 291



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 12/88 (13%)

Query: 243 GH-TPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPW---------FRGGGVTN 292
           GH  PV SL++ P    L SAS  D ++RVW +S +TC  + W              +  
Sbjct: 134 GHDAPVLSLSFDPKDIFLASAS-CDGSVRVWQISDQTCA-ISWPLLQKCNDVINAKSICR 191

Query: 293 LLWSPDGSKILATTPSAVFRVWEAQMWT 320
           L W P   K+LA       +++  + W+
Sbjct: 192 LAWQPKSGKLLAIPVEKSVKLYRRESWS 219



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 40/164 (24%), Positives = 69/164 (42%), Gaps = 24/164 (14%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTL-DPTSLSTRPS-SGCAQVLSHPGHTPVTSLAWA 253
           V SL++ P    + + +C   + +W + D T   + P    C  V++      +  LAW 
Sbjct: 139 VLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKS---ICRLAWQ 195

Query: 254 PSGGRLLSASPVDAAIRVW---------DVSTETCVPLPWFRGGGVTNLLWSPDGSKILA 304
           P  G+LL A PV+ +++++         D+S         F    +  + WSP G  + A
Sbjct: 196 PKSGKLL-AIPVEKSVKLYRRESWSHQFDLSDN-------FISQTLNIVTWSPCGQYLAA 247

Query: 305 TTPSAVFRVWEAQMWTC-ERWPTLSGRCQTG-CWSPDGSRLLFT 346
            + + +  VW  +   C ER     G    G  W P   R+ +T
Sbjct: 248 GSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYT 291


>gi|46409657 WD repeat domain 56 [Homo sapiens]
          Length = 777

 Score = 42.4 bits (98), Expect = 0.001
 Identities = 48/167 (28%), Positives = 68/167 (40%), Gaps = 10/167 (5%)

Query: 140 IAEFAQVTNWSSC-CLRVFAWHPHTNKFAVALLDDSVRV-YNASSTIVPSLKHRLQRNVA 197
           + E  Q+  WS    LR       T  ++VA   DS +V Y A   ++      LQ N  
Sbjct: 124 VGEDGQIKIWSKTGMLRSTLAQQGTPVYSVAWGPDSEKVLYTAGKQLIIK---PLQPNAK 180

Query: 198 SLAWKPLSASVLAVACQSC--ILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPS 255
            L WK     +L V   S   +++   +        S G     S P   P+TS+AWAP 
Sbjct: 181 VLQWKAHDGIILKVDWNSVNDLILSAGEDCKYKVWDSYGRPLYNSQPHEHPITSVAWAPD 240

Query: 256 GGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKI 302
           G   L A      +R+ D  T     L     G + N+ WS DG++I
Sbjct: 241 GE--LFAVGSFHTLRLCD-KTGWSYALEKPNTGSIFNIAWSIDGTQI 284


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 36/165 (21%), Positives = 66/165 (40%), Gaps = 11/165 (6%)

Query: 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCI 217
           AW   +N    A  D ++++++ SS             V    + P S  +++ +    +
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 218 LIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE 277
            IW +         +  C + L  P H+   S       G L+ +S  D   R+WD ++ 
Sbjct: 154 RIWDVK--------TGKCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203

Query: 278 TCV-PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC 321
            C+  L       V+ + +SP+G  ILA T     ++W+     C
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/132 (21%), Positives = 57/132 (43%), Gaps = 12/132 (9%)

Query: 190 HRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTS 249
           H+L   ++ +AW   S  +++ +    + IW +         S  C + L   GH+    
Sbjct: 86  HKL--GISDVAWSSDSNLLVSASDDKTLKIWDVS--------SGKCLKTLK--GHSNYVF 133

Query: 250 LAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSA 309
                    L+ +   D ++R+WDV T  C+         V+ + ++ DGS I++++   
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 310 VFRVWEAQMWTC 321
           + R+W+     C
Sbjct: 194 LCRIWDTASGQC 205



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 19/87 (21%), Positives = 36/87 (41%), Gaps = 2/87 (2%)

Query: 243 GHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKI 302
           GHT   S       G  L++S  D  I++W                G++++ WS D + +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 303 LATTPSAVFRVWEAQMWTCERWPTLSG 329
           ++ +     ++W+     C +  TL G
Sbjct: 103 VSASDDKTLKIWDVSSGKCLK--TLKG 127


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 36/165 (21%), Positives = 66/165 (40%), Gaps = 11/165 (6%)

Query: 158 AWHPHTNKFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCI 217
           AW   +N    A  D ++++++ SS             V    + P S  +++ +    +
Sbjct: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153

Query: 218 LIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTE 277
            IW +         +  C + L  P H+   S       G L+ +S  D   R+WD ++ 
Sbjct: 154 RIWDVK--------TGKCLKTL--PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 203

Query: 278 TCV-PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC 321
            C+  L       V+ + +SP+G  ILA T     ++W+     C
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/132 (21%), Positives = 57/132 (43%), Gaps = 12/132 (9%)

Query: 190 HRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTS 249
           H+L   ++ +AW   S  +++ +    + IW +         S  C + L   GH+    
Sbjct: 86  HKL--GISDVAWSSDSNLLVSASDDKTLKIWDVS--------SGKCLKTLK--GHSNYVF 133

Query: 250 LAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTPSA 309
                    L+ +   D ++R+WDV T  C+         V+ + ++ DGS I++++   
Sbjct: 134 CCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 310 VFRVWEAQMWTC 321
           + R+W+     C
Sbjct: 194 LCRIWDTASGQC 205



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 19/87 (21%), Positives = 36/87 (41%), Gaps = 2/87 (2%)

Query: 243 GHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKI 302
           GHT   S       G  L++S  D  I++W                G++++ WS D + +
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 303 LATTPSAVFRVWEAQMWTCERWPTLSG 329
           ++ +     ++W+     C +  TL G
Sbjct: 103 VSASDDKTLKIWDVSSGKCLK--TLKG 127


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 13/122 (10%)

Query: 234 GCAQ-VLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
           GC + V +  GHT  V ++ W PSG  L S S  D  +++W +  E C+         + 
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSD-DMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 292 NLLWSPDG-------SKILATTPS--AVFRVWEAQMWTCERWPTLSGR-CQTGCWSPDGS 341
            + WSP G       S I+  + S  +  R+W+ +   C    T       +  +SPDG 
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467

Query: 342 RL 343
            L
Sbjct: 468 YL 469



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 21/156 (13%)

Query: 171 LDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTR 230
           +D  V + ++ +T++       +  V   AW P+S  + + +  S   IW L+  S    
Sbjct: 163 IDGEVEIPSSKATVLRGH----ESEVFICAWNPVSDLLASGSGDSTARIWNLNENS---- 214

Query: 231 PSSGCAQ-VLSH---------PGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCV 280
            + G  Q VL H         P +  VTSL W  + G LL+    D   R+W        
Sbjct: 215 -NGGSTQLVLRHCIREGGHDVPSNKDVTSLDW-NTNGTLLATGSYDGFARIWTEDGNLAS 272

Query: 281 PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
            L   + G +  L W+  G+ IL+        +W+A
Sbjct: 273 TLGQHK-GPIFALKWNRKGNYILSAGVDKTTIIWDA 307



 Score = 29.3 bits (64), Expect = 9.7
 Identities = 26/116 (22%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 160 HPHTN-KFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCIL 218
           +P++N   A A  D +VR+++    +      + Q  V S+A+ P    + + +   C+ 
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 219 IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           IW     +L          V S+ G   +  + W   G + + AS  D ++ V D+
Sbjct: 480 IWNTQSGNL----------VHSYRGTGGIFEVCWNARGDK-VGASASDGSVCVLDL 524


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 13/122 (10%)

Query: 234 GCAQ-VLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
           GC + V +  GHT  V ++ W PSG  L S S  D  +++W +  E C+         + 
Sbjct: 349 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSD-DMTLKIWSMKQEVCIHDLQAHNKEIY 407

Query: 292 NLLWSPDG-------SKILATTPS--AVFRVWEAQMWTCERWPTLSGR-CQTGCWSPDGS 341
            + WSP G       S I+  + S  +  R+W+ +   C    T       +  +SPDG 
Sbjct: 408 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 467

Query: 342 RL 343
            L
Sbjct: 468 YL 469



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 21/156 (13%)

Query: 171 LDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTR 230
           +D  V + ++ +T++       +  V   AW P+S  + + +  S   IW L+  S    
Sbjct: 163 IDGEVEIPSSKATVLRGH----ESEVFICAWNPVSDLLASGSGDSTARIWNLNENS---- 214

Query: 231 PSSGCAQ-VLSH---------PGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCV 280
            + G  Q VL H         P +  VTSL W  + G LL+    D   R+W        
Sbjct: 215 -NGGSTQLVLRHCIREGGHDVPSNKDVTSLDW-NTNGTLLATGSYDGFARIWTEDGNLAS 272

Query: 281 PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
            L   + G +  L W+  G+ IL+        +W+A
Sbjct: 273 TLGQHK-GPIFALKWNRKGNYILSAGVDKTTIIWDA 307



 Score = 29.3 bits (64), Expect = 9.7
 Identities = 26/116 (22%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 160 HPHTN-KFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCIL 218
           +P++N   A A  D +VR+++    +      + Q  V S+A+ P    + + +   C+ 
Sbjct: 420 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 479

Query: 219 IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           IW     +L          V S+ G   +  + W   G + + AS  D ++ V D+
Sbjct: 480 IWNTQSGNL----------VHSYRGTGGIFEVCWNARGDK-VGASASDGSVCVLDL 524


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 13/122 (10%)

Query: 234 GCAQ-VLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
           GC + V +  GHT  V ++ W PSG  L S S  D  +++W +  E C+         + 
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSD-DMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 292 NLLWSPDG-------SKILATTPS--AVFRVWEAQMWTCERWPTLSGR-CQTGCWSPDGS 341
            + WSP G       S I+  + S  +  R+W+ +   C    T       +  +SPDG 
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518

Query: 342 RL 343
            L
Sbjct: 519 YL 520



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 21/156 (13%)

Query: 171 LDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTR 230
           +D  V + ++ +T++       +  V   AW P+S  + + +  S   IW L+  S    
Sbjct: 214 IDGEVEIPSSKATVLRGH----ESEVFICAWNPVSDLLASGSGDSTARIWNLNENS---- 265

Query: 231 PSSGCAQ-VLSH---------PGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCV 280
            + G  Q VL H         P +  VTSL W  + G LL+    D   R+W        
Sbjct: 266 -NGGSTQLVLRHCIREGGHDVPSNKDVTSLDW-NTNGTLLATGSYDGFARIWTEDGNLAS 323

Query: 281 PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
            L   + G +  L W+  G+ IL+        +W+A
Sbjct: 324 TLGQHK-GPIFALKWNRKGNYILSAGVDKTTIIWDA 358



 Score = 29.3 bits (64), Expect = 9.7
 Identities = 26/116 (22%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 160 HPHTN-KFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCIL 218
           +P++N   A A  D +VR+++    +      + Q  V S+A+ P    + + +   C+ 
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 219 IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           IW     +L          V S+ G   +  + W   G + + AS  D ++ V D+
Sbjct: 531 IWNTQSGNL----------VHSYRGTGGIFEVCWNARGDK-VGASASDGSVCVLDL 575


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/122 (27%), Positives = 53/122 (43%), Gaps = 13/122 (10%)

Query: 234 GCAQ-VLSHPGHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVT 291
           GC + V +  GHT  V ++ W PSG  L S S  D  +++W +  E C+         + 
Sbjct: 400 GCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSD-DMTLKIWSMKQEVCIHDLQAHNKEIY 458

Query: 292 NLLWSPDG-------SKILATTPS--AVFRVWEAQMWTCERWPTLSGR-CQTGCWSPDGS 341
            + WSP G       S I+  + S  +  R+W+ +   C    T       +  +SPDG 
Sbjct: 459 TIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGK 518

Query: 342 RL 343
            L
Sbjct: 519 YL 520



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 39/156 (25%), Positives = 64/156 (41%), Gaps = 21/156 (13%)

Query: 171 LDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCILIWTLDPTSLSTR 230
           +D  V + ++ +T++       +  V   AW P+S  + + +  S   IW L+  S    
Sbjct: 214 IDGEVEIPSSKATVLRGH----ESEVFICAWNPVSDLLASGSGDSTARIWNLNENS---- 265

Query: 231 PSSGCAQ-VLSH---------PGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCV 280
            + G  Q VL H         P +  VTSL W  + G LL+    D   R+W        
Sbjct: 266 -NGGSTQLVLRHCIREGGHDVPSNKDVTSLDW-NTNGTLLATGSYDGFARIWTEDGNLAS 323

Query: 281 PLPWFRGGGVTNLLWSPDGSKILATTPSAVFRVWEA 316
            L   + G +  L W+  G+ IL+        +W+A
Sbjct: 324 TLGQHK-GPIFALKWNRKGNYILSAGVDKTTIIWDA 358



 Score = 29.3 bits (64), Expect = 9.7
 Identities = 26/116 (22%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 160 HPHTN-KFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCIL 218
           +P++N   A A  D +VR+++    +      + Q  V S+A+ P    + + +   C+ 
Sbjct: 471 NPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVH 530

Query: 219 IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           IW     +L          V S+ G   +  + W   G + + AS  D ++ V D+
Sbjct: 531 IWNTQSGNL----------VHSYRGTGGIFEVCWNARGDK-VGASASDGSVCVLDL 575


>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
          Length = 461

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%)

Query: 196 VASLAWKPLSASVLAVACQSC-ILIWTLDPTSLSTRPSSGCAQVLSHP-----GHTP-VT 248
           V  +AW P + +V+A   + C +++W +        P  G    L  P     GHT  V 
Sbjct: 84  VLDIAWCPHNDNVIASGSEDCTVMVWEI--------PDGGLMLPLREPVVTLEGHTKRVG 135

Query: 249 SLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPL--PWFRGGGVTNLLWSPDGSKILATT 306
            +AW  +   +L ++  D  I VWDV T   +    P      + ++ WS DG  I  + 
Sbjct: 136 IVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSC 195

Query: 307 PSAVFRVWEAQMWT 320
                R+ E +  T
Sbjct: 196 RDKRVRIIEPRKGT 209



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 11/33 (33%), Positives = 19/33 (57%), Gaps = 1/33 (3%)

Query: 243 GHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           GHT PV  +AW P    ++++   D  + VW++
Sbjct: 79  GHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEI 111


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 50/241 (20%), Positives = 82/241 (34%), Gaps = 67/241 (27%)

Query: 156 VFAWHPHTNKFAVALLDDSVRVYNASSTIVPS-----LKHRLQ---------RNVASLAW 201
           + AW+P ++  A    D + R++N S           L+H ++         ++V SL W
Sbjct: 174 ICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDW 233

Query: 202 KPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLS 261
                 +   +      IWT D    ST        +  H G  P+ +L W   G  +LS
Sbjct: 234 NSEGTLLATGSYDGFARIWTKDGNLAST--------LGQHKG--PIFALKWNKKGNFILS 283

Query: 262 ASPVDAAIRVWDV------------------------------STETCV---------PL 282
           A  VD    +WD                               ST+ C+         P+
Sbjct: 284 AG-VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPI 342

Query: 283 PWFRG--GGVTNLLWSPDGSKILATTPSAVFRVWEAQMWTC-ERWPTLSGRCQTGCWSPD 339
             F+G    V  + W P G+ + + +     ++W  +   C       +    T  WSP 
Sbjct: 343 KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402

Query: 340 G 340
           G
Sbjct: 403 G 403



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 28/156 (17%), Positives = 61/156 (39%), Gaps = 17/156 (10%)

Query: 196 VASLAWKPLSASVLAVACQSCILIWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPS 255
           V ++ W P    + + +    + IW++            C   L    +  + ++ W+P+
Sbjct: 352 VNAIKWDPTGNLLASCSDDMTLKIWSMK--------QDNCVHDLQ-AHNKEIYTIKWSPT 402

Query: 256 G--------GRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKILATTP 307
           G          +L+++  D+ +R+WDV    C+         V ++ +SPDG  + + + 
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSF 462

Query: 308 SAVFRVWEAQMWTCERWPTLSGRCQTGCWSPDGSRL 343
                +W  Q          +G     CW+  G ++
Sbjct: 463 DKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKV 498



 Score = 36.2 bits (82), Expect = 0.079
 Identities = 27/112 (24%), Positives = 45/112 (40%), Gaps = 12/112 (10%)

Query: 243 GHT-PVTSLAWAPSGGRLLSASPVDAAIRVWDVSTETCVPLPWFRGGGVTNLLWSPDGS- 300
           GHT  V ++ W P+G  L S S  D  +++W +  + CV         +  + WSP G  
Sbjct: 347 GHTNEVNAIKWDPTGNLLASCSD-DMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPG 405

Query: 301 --------KILATTPSAVFRVWEAQMWTCERWPTLSGR-CQTGCWSPDGSRL 343
                    + + +  +  R+W+     C    T       +  +SPDG  L
Sbjct: 406 TNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYL 457



 Score = 29.6 bits (65), Expect = 7.4
 Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 12/116 (10%)

Query: 160 HPHTN-KFAVALLDDSVRVYNASSTIVPSLKHRLQRNVASLAWKPLSASVLAVACQSCIL 218
           +P+ N   A A  D +VR+++    I      + Q  V S+A+ P    + + +   C+ 
Sbjct: 408 NPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVH 467

Query: 219 IWTLDPTSLSTRPSSGCAQVLSHPGHTPVTSLAWAPSGGRLLSASPVDAAIRVWDV 274
           IW     +L          V S+ G   +  + W  +G + + AS  D ++ V D+
Sbjct: 468 IWNTQTGAL----------VHSYRGTGGIFEVCWNAAGDK-VGASASDGSVCVLDL 512


>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 6/128 (4%)

Query: 196 VASLAWKPLSASVLAVACQSC-ILIWTLDPTSLSTRPSSGCAQVLSHPGHTP-VTSLAWA 253
           V  + W P +  V+A   + C +++W +    L T P +    VL   GHT  V  +AW 
Sbjct: 85  VLDIDWCPHNDEVIASGSEDCTVMVWQIPENGL-TSPLTEPVVVLE--GHTKRVGIIAWH 141

Query: 254 PSGGRLLSASPVDAAIRVWDVST-ETCVPLPWFRGGGVTNLLWSPDGSKILATTPSAVFR 312
           P+   +L ++  D  + +W+V T E    L       + N+ W+ +GS   +       R
Sbjct: 142 PTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVR 201

Query: 313 VWEAQMWT 320
           + + +  T
Sbjct: 202 IIDPRRGT 209


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.452 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,976,083
Number of Sequences: 37866
Number of extensions: 1451227
Number of successful extensions: 5979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 130
Number of HSP's that attempted gapping in prelim test: 5533
Number of HSP's gapped (non-prelim): 480
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.