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Search of human proteins with 4504379
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
(907 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 1815 0.0
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 970 0.0
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 926 0.0
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 810 0.0
gi|62912474 leucine-rich repeat-containing G protein-coupled rec... 733 0.0
gi|31657138 follicle stimulating hormone receptor isoform 1 prec... 201 3e-51
gi|106067657 luteinizing hormone/choriogonadotropin receptor pre... 198 2e-50
gi|64085121 thyroid stimulating hormone receptor isoform 1 precu... 190 6e-48
gi|31657136 follicle stimulating hormone receptor isoform 2 prec... 185 1e-46
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 170 5e-42
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 170 5e-42
gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo... 152 1e-36
gi|225579152 insulin-like growth factor binding protein, acid la... 150 4e-36
gi|4826772 insulin-like growth factor binding protein, acid labi... 150 4e-36
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 147 3e-35
gi|198041768 synleurin [Homo sapiens] 146 7e-35
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 145 1e-34
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 145 2e-34
gi|45505137 podocan [Homo sapiens] 139 9e-33
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 139 1e-32
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 135 1e-31
gi|188528675 slit homolog 1 [Homo sapiens] 135 1e-31
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 135 2e-31
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 134 5e-31
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 130 7e-30
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 126 8e-29
gi|11321571 slit homolog 3 [Homo sapiens] 126 8e-29
gi|4759146 slit homolog 2 [Homo sapiens] 125 1e-28
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 124 4e-28
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 124 4e-28
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 1815 bits (4702), Expect = 0.0
Identities = 907/907 (100%), Positives = 907/907 (100%)
Query: 1 MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSEL 60
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSEL
Sbjct: 1 MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSEL 60
Query: 61 PSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM 120
PSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM
Sbjct: 61 PSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM 120
Query: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ 180
LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ
Sbjct: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ 180
Query: 181 AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD 240
AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD
Sbjct: 181 AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD 240
Query: 241 LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA 300
LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA
Sbjct: 241 LNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSA 300
Query: 301 FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS 360
FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS
Sbjct: 301 FQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS 360
Query: 361 YNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFST 420
YNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFST
Sbjct: 361 YNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFST 420
Query: 421 LPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC 480
LPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC
Sbjct: 421 LPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCC 480
Query: 481 AFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQ 540
AFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQ
Sbjct: 481 AFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQ 540
Query: 541 CSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIA 600
CSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIA
Sbjct: 541 CSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIA 600
Query: 601 AVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAAL 660
AVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAAL
Sbjct: 601 AVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAAL 660
Query: 661 ERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEP 720
ERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEP
Sbjct: 661 ERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEP 720
Query: 721 STMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNC 780
STMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNC
Sbjct: 721 STMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNC 780
Query: 781 PVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYV 840
PVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYV
Sbjct: 781 PVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYV 840
Query: 841 WTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSS 900
WTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSS
Sbjct: 841 WTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSS 900
Query: 901 VAFVPCL 907
VAFVPCL
Sbjct: 901 VAFVPCL 907
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 970 bits (2507), Expect = 0.0
Identities = 495/893 (55%), Positives = 634/893 (70%), Gaps = 19/893 (2%)
Query: 22 GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL 81
G +P+ G CP CHC+ DG ++L DCS+LGLS +P +L T+YLDLSMNN+++L
Sbjct: 23 GGAPQPGPGPTACPAPCHCQEDG-IMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
Query: 82 LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
P LRFLEELRL+GN L++IP AF+GLYSLK+LMLQNNQL +P EAL L SLQ
Sbjct: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
Query: 142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHI 201
SLRLDAN IS VP F GL SLRHLWLDDNALTEIPV+A +L ALQAMTLALN+I HI
Sbjct: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
Query: 202 PDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKE 261
PDYAF NL+SLVVLHLHNNRI LG F+GLH+LETLDLNYN L EFP AIRTL L+E
Sbjct: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQE 261
Query: 262 LGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEF 321
LGFH+NNI++IPEKAF+GNP L TIHFYDNPIQFVGRSAFQ+LP+L TL+LNGA I EF
Sbjct: 262 LGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEF 321
Query: 322 PDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDL 381
PDL GT +LE LTLT A I LP +C QLP L+VL+LS+N +E+LPS CQKL++I L
Sbjct: 322 PDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGL 381
Query: 382 RHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITG 441
+HN I+EI DTF QL SL++L+L+WN I IHP AFSTL SL+KLDL+ N L++ P+ G
Sbjct: 382 QHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAG 441
Query: 442 LHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGD-N 500
L GL HLKL GN AL S ++FP+L+++E+PYAYQCC +G+C + +K S QW D +
Sbjct: 442 LGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLH 501
Query: 501 SSMDDLHKKDAGMFQAQDE----RDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLD 556
++ K+ G+ Q E +DL++ L+ ED K SVQCSP+PGPFKPCE+L +
Sbjct: 502 LDDEESSKRPLGLLARQAENHYDQDLDELQLEM-EDSKPHPSVQCSPTPGPFKPCEYLFE 560
Query: 557 GWLIRIGVWTIAVLALTCNALVTSTVFR-SPLYISPIKLLIGVIAAVNMLTGVSSAVLAG 615
W IR+ VW I +L++ CN LV TVF P+ + P+K ++G IA N LTG+S +LA
Sbjct: 561 SWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLAS 620
Query: 616 VDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETK 675
VDA TFG F+ +GA WE G+GC GFL++ SE+SV LLTLAA++ SV +
Sbjct: 621 VDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKS 680
Query: 676 APFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPL--PFGEPSTMGYMVALILLN 733
S++ +L C LA AA+PL +YGASPLCLP P G+P+ +G+ VAL+++N
Sbjct: 681 PSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMN 740
Query: 734 SLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINL 793
S CFL++ AY KLYC+L +GD E +WDC+MV+H+A L+F + +L CPVAFLSF+S++ L
Sbjct: 741 SFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGL 800
Query: 794 TFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSIN 853
++PE +K +LLVV+PLPACLNPLLY+LFNPHF++DL LR + L
Sbjct: 801 FPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRA-----GDSGPLAYAA 855
Query: 854 SDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYPVTESCHLSSVAFVPC 906
+ ++EK SCDSTQALV F+ + + + P P E+ SV + C
Sbjct: 856 AGELEKSSCDSTQALVAFSDVDLILEASEAGRP----PGLETYGFPSVTLISC 904
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 926 bits (2392), Expect = 0.0
Identities = 475/855 (55%), Positives = 607/855 (70%), Gaps = 18/855 (2%)
Query: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119
L +S+ S DLSMNN+++L P LRFLEELRL+GN L++IP AF+GLYSLK+L
Sbjct: 8 LVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKIL 67
Query: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179
MLQNNQL +P EAL L SLQSLRLDAN IS VP F GL SLRHLWLDDNALTEIPV
Sbjct: 68 MLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPV 127
Query: 180 QAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETL 239
+A +L ALQAMTLALN+I HIPDYAF NL+SLVVLHLHNNRI LG F+GLH+LETL
Sbjct: 128 RALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETL 187
Query: 240 DLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRS 299
DLNYN L EFP AIRTL L+ELGFH+NNI++IPEKAF+GNP L TIHFYDNPIQFVGRS
Sbjct: 188 DLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRS 247
Query: 300 AFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDL 359
AFQ+LP+L TL+LNGA I EFPDL GT +LE LTLT A I LP +C QLP L+VL+L
Sbjct: 248 AFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLEL 307
Query: 360 SYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFS 419
S+N +E+LPS CQKL++I L+HN I+EI DTF QL SL++L+L+WN I IHP AFS
Sbjct: 308 SHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 367
Query: 420 TLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQC 479
TL SL+KLDL+ N L++ P+ GL GL HLKL GN AL S ++FP+L+++E+PYAYQC
Sbjct: 368 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQC 427
Query: 480 CAFGVCENAYKISNQWNKGD-NSSMDDLHKKDAGMFQAQDE----RDLEDFLLDFEEDLK 534
C +G+C + +K S QW D + ++ K+ G+ Q E +DL++ L+ ED K
Sbjct: 428 CPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEM-EDSK 486
Query: 535 ALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFR-SPLYISPIK 593
SVQCSP+PGPFKPCE+L + W IR+ VW I +L++ CN LV TVF P+ + P+K
Sbjct: 487 PHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVK 546
Query: 594 LLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVF 653
++G IA N LTG+S +LA VDA TFG F+ +GA WE G+GC GFL++ SE+SV
Sbjct: 547 FVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVL 606
Query: 654 LLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCL 713
LLTLAA++ SV + S++ +L C LA AA+PL +YGASPLCL
Sbjct: 607 LLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCL 666
Query: 714 PL--PFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALL 771
P P G+P+ +G+ VAL+++NS CFL++ AY KLYC+L +GD E +WDC+MV+H+A L
Sbjct: 667 PYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWL 726
Query: 772 LFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDL 831
+F + +L CPVAFLSF+S++ L ++PE +K +LLVV+PLPACLNPLLY+LFNPHF++DL
Sbjct: 727 IFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDL 786
Query: 832 VSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDLPPSSVPSPAYP 891
LR + L + ++EK SCDSTQALV F+ + + + P P
Sbjct: 787 RRLRPRA-----GDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRP----P 837
Query: 892 VTESCHLSSVAFVPC 906
E+ SV + C
Sbjct: 838 GLETYGFPSVTLISC 852
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 810 bits (2093), Expect = 0.0
Identities = 427/828 (51%), Positives = 549/828 (66%), Gaps = 14/828 (1%)
Query: 10 LSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTS 69
L L L L GS+ SG C C C+ D R VDCS GL+ +P LS FT
Sbjct: 5 LGLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRR----VDCSGKGLTAVPEGLSAFTQ 60
Query: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
LD+SMNNI+QL + + FLEEL+LAGN L++I A +GL LKVL LQNNQL+ V
Sbjct: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
Query: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
P+EA++ L +LQSLRLDANHI+ VP F GL LRHLWLDDN+LTE+PV +L LQ
Sbjct: 121 PSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQ 180
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
A+TLALNKI IPD+AF NLSSLVVLHLHNN+I SL + CFDGL +LETLDLNYNNL EF
Sbjct: 181 ALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF 240
Query: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
P AI+ L +LKELGFHSN+I IP+ AF GNP L TIH YDNP+ FVG SAF +L +L +
Sbjct: 241 PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHS 300
Query: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
L + GAS + +FP+LTGT +LESLTLTG +ISS+P +C + L+ LDLSYN + DLPS
Sbjct: 301 LVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS 360
Query: 370 FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDL 429
F+ C L++I L+ N+IY+IK TFQ L+SLR L+L+ N I IH AF+TL + LD+
Sbjct: 361 FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDV 420
Query: 430 SSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAY 489
S N L+SFP GL+GL LKL GN L+ +++++F L+ + +PYAYQCCAF C++
Sbjct: 421 SFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYA 480
Query: 490 KISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFK 549
+ N DNS D ++ G A + L+ EE + + + C+PS G FK
Sbjct: 481 NL----NTEDNSLQDHSVAQEKGTADAANVTS----TLENEEHSQII--IHCTPSTGAFK 530
Query: 550 PCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVS 609
PCE+LL W+IR+ VW I ++AL N LV T F S + KL IG+I+ N+ G+
Sbjct: 531 PCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLISVSNLFMGIY 590
Query: 610 SAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYS 669
+ +L +DA ++G FA G WWE G GC V GFL++F+SES++FLL LA +ER S K
Sbjct: 591 TGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDI 650
Query: 670 AKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVAL 729
K +V LL L A PL +Y ASPLCLP P GE ++G+ V L
Sbjct: 651 MKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETPSLGFTVTL 710
Query: 730 ILLNSLCFLMMTIAYTKLYCNLDKGDLENIWDCSMVKHIALLLFTNCILNCPVAFLSFSS 789
+LLNSL FL+M + YTKLYCNL+K DL SM+KH+A L+FTNCI CPVAF SF+
Sbjct: 711 VLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAP 770
Query: 790 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSLRKQ 837
LI ISPE++K + L+ PLPACLNP+LY+ FNP FKED L+++
Sbjct: 771 LITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKEDWKLLKRR 818
>gi|62912474 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 3 [Homo sapiens]
Length = 828
Score = 733 bits (1892), Expect = 0.0
Identities = 377/746 (50%), Positives = 504/746 (67%), Gaps = 18/746 (2%)
Query: 169 LDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKK 228
L N LTE+ F L L+ + L+ N + HIP AF L SL +L L NN++ + +
Sbjct: 30 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 89
Query: 229 CFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF 288
L SL++LDLNYN L EFP AIRTL L+ELGFH+NNI++IPEKAF+GNP L TIHF
Sbjct: 90 ALWELPSLQSLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 149
Query: 289 YDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVC 348
YDNPIQFVGRSAFQ+LP+L TL+LNGA I EFPDL GT +LE LTLT A I LP +C
Sbjct: 150 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMC 209
Query: 349 NQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
QLP L+VL+LS+N +E+LPS CQKL++I L+HN I+EI DTF QL SL++L+L+WN
Sbjct: 210 QQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWN 269
Query: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPEL 468
I IHP AFSTL SL+KLDL+ N L++ P+ GL GL HLKL GN AL S ++FP+L
Sbjct: 270 AIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKL 329
Query: 469 KVIEMPYAYQCCAFGVCENAYKISNQWNKGD-NSSMDDLHKKDAGMFQAQDE----RDLE 523
+++E+PYAYQCC +G+C + +K S QW D + ++ K+ G+ Q E +DL+
Sbjct: 330 RILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLD 389
Query: 524 DFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVF 583
+ L+ ED K SVQCSP+PGPFKPCE+L + W IR+ VW I +L++ CN LV TVF
Sbjct: 390 ELQLEM-EDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVF 448
Query: 584 R-SPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGF 642
P+ + P+K ++G IA N LTG+S +LA VDA TFG F+ +GA WE G+GC GF
Sbjct: 449 AGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGF 508
Query: 643 LSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLG 702
L++ SE+SV LLTLAA++ SV + S++ +L C LA AA+PL
Sbjct: 509 LAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLAS 568
Query: 703 GSKYGASPLCLPL--PFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDLENIW 760
+YGASPLCLP P G+P+ +G+ VAL+++NS CFL++ AY KLYC+L +GD E +W
Sbjct: 569 VGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW 628
Query: 761 DCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLY 820
DC+MV+H+A L+F + +L CPVAFLSF+S++ L ++PE +K +LLVV+PLPACLNPLLY
Sbjct: 629 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY 688
Query: 821 ILFNPHFKEDLVSLRKQTYVWTRSKHPSLMSINSDDVEKQSCDSTQALVTFTSSSITYDL 880
+LFNPHF++DL LR + L + ++EK SCDSTQALV F+ + +
Sbjct: 689 LLFNPHFRDDLRRLRPRA-----GDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEA 743
Query: 881 PPSSVPSPAYPVTESCHLSSVAFVPC 906
+ P P E+ SV + C
Sbjct: 744 SEAGRP----PGLETYGFPSVTLISC 765
Score = 35.4 bits (80), Expect = 0.24
Identities = 27/78 (34%), Positives = 39/78 (50%), Gaps = 3/78 (3%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
+ L N I ++ + L L+ L L+ NA+ I AF+ L+SL L L +NQL +P
Sbjct: 240 IGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 299
Query: 131 TEALQNLRSLQSLRLDAN 148
L L L L+L N
Sbjct: 300 ---LAGLGGLMHLKLKGN 314
>gi|31657138 follicle stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 695
Score = 201 bits (510), Expect = 3e-51
Identities = 163/630 (25%), Positives = 286/630 (45%), Gaps = 62/630 (9%)
Query: 221 RIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN 280
++ + K F G LE ++++ N++ E A SNL +L H I EKA
Sbjct: 57 KLRVIQKGAFSGFGDLEKIEISQNDVLEVIEA-DVFSNLPKL--HEIRI----EKA---- 105
Query: 281 PSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQI 340
N + ++ AFQ+LP L+ L ++ I PD+ +I
Sbjct: 106 ----------NNLLYINPEAFQNLPNLQYLLISNTG-IKHLPDVH-------------KI 141
Query: 341 SSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSL 400
SL + + + N+ + + N L SV L K N I EI F L
Sbjct: 142 HSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNK-----NGIQEIHNCAFNGT-QL 195
Query: 401 RSLNLAWNKIAIIHPN-AFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSL 459
LNL+ N PN F + LD+S + S P GL L L+ + L+ L
Sbjct: 196 DELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKL 255
Query: 460 ISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDE 519
+ E L + Y CCAF N + ++ + N S+ L ++ M QA+ +
Sbjct: 256 PTLEKLVALMEASLTYPSHCCAFA---NWRRQISELHPICNKSI--LRQEVDYMTQARGQ 310
Query: 520 RD-------------LEDFLLDFEEDL-KALHSVQCSPSPGPFKPCEHLLDGWLIRIGVW 565
R + +F+ DL + V CSP P F PCE ++ ++R+ +W
Sbjct: 311 RSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIW 370
Query: 566 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFA 625
I++LA+T N +V + S ++ + L+ +A ++ G+ ++A VD T +
Sbjct: 371 FISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYH 430
Query: 626 RHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVII 685
+ W+ G GC GF ++FASE SV+ LT LER ++ ++ + + K ++
Sbjct: 431 NYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVM 490
Query: 686 LLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYT 745
++ + A A P+ G S Y +CLP+ P + Y+++L++LN L F+++ Y
Sbjct: 491 VMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYI 550
Query: 746 KLYCNLDKGDL-ENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFI 804
+Y + ++ + D + K +A+L+FT+ + P++F + S+ + + I+ K +
Sbjct: 551 HIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKIL 610
Query: 805 LLVVVPLPACLNPLLYILFNPHFKEDLVSL 834
L++ P+ +C NP LY +F +F+ D L
Sbjct: 611 LVLFHPINSCANPFLYAIFTKNFRRDFFIL 640
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/223 (29%), Positives = 103/223 (46%), Gaps = 39/223 (17%)
Query: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
CHC R+ L C + ++E+PS DL N I ELR
Sbjct: 23 CHCS--NRVFL---CQESKVTEIPS---------DLPRNAI---------------ELRF 53
Query: 98 AGNALTYIPKGAFTGLYSL-KVLMLQNNQLRHVPTEALQNLRSLQSLRLD-ANHISYVPP 155
L I KGAF+G L K+ + QN+ L + + NL L +R++ AN++ Y+ P
Sbjct: 54 VLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINP 113
Query: 156 SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN---KIHHIPDYAFGNLS-S 211
F L +L++L + + + +P + +LQ + L + IH I +F LS
Sbjct: 114 EAFQNLPNLQYLLISNTGIKHLP--DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFE 171
Query: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLN-YNNLDEFPTAI 253
V+L L+ N I + F+G L+ L+L+ NNL+E P +
Sbjct: 172 SVILWLNKNGIQEIHNCAFNGTQ-LDELNLSDNNNLEELPNDV 213
>gi|106067657 luteinizing hormone/choriogonadotropin receptor
precursor [Homo sapiens]
Length = 699
Score = 198 bits (503), Expect = 2e-50
Identities = 162/618 (26%), Positives = 285/618 (46%), Gaps = 34/618 (5%)
Query: 228 KCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHS-NNIRSIPEKAFVG--NPSL 283
+C L L L Y + P+ A R L+ + ++ +++ I AF N S
Sbjct: 43 RCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSE 102
Query: 284 ITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSL 343
I I N ++++ AF +LP L+ L++ I +FPD+T + ES +
Sbjct: 103 ILIQNTKN-LRYIEPGAFINLPRLKYLSICNTG-IRKFPDVTKVFSSESNFIL------- 153
Query: 344 PQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSL 403
+C+ NL + + N + + + SV KL N E++ F +L SL
Sbjct: 154 --EICD---NLHITTIPGNAFQGMNNESVTLKLYG-----NGFEEVQSHAFNGT-TLTSL 202
Query: 404 NLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISS 462
L N + +H AF LD+SS L + P GL + L T +++L+ L S
Sbjct: 203 ELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSR 262
Query: 463 ENFPELKVIEMPYAYQCCAFGVCEN-----AYKISNQWNKGDNSSMDDLHKKDAGMFQAQ 517
E F L + Y CCAF ++ IS ++K S++ ++ K
Sbjct: 263 ETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLA 322
Query: 518 DERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNAL 577
E +L + D+E + +C+P P F PCE ++ +R+ +W I +LA+ N
Sbjct: 323 -ESELSGW--DYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMT 379
Query: 578 VTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGC 637
V + S ++ + L+ ++ + G+ ++A VD+ T G + H W+ G GC
Sbjct: 380 VLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGC 439
Query: 638 HVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAA 697
GF ++FASE SV+ LT+ LER ++ Y+ + K +I+L L + +A
Sbjct: 440 STAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAM 499
Query: 698 VPLLGGSKYGASPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNLDKGDL- 756
+PL+G S Y +C P+ + Y++ +++LN + F ++ Y K+Y + +L
Sbjct: 500 LPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELM 559
Query: 757 ENIWDCSMVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLN 816
D + K +A+L+FT+ P++F + S+ + I+ K +L++ P+ +C N
Sbjct: 560 ATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCAN 619
Query: 817 PLLYILFNPHFKEDLVSL 834
P LY +F F+ D L
Sbjct: 620 PFLYAIFTKTFQRDFFLL 637
Score = 50.8 bits (120), Expect = 6e-06
Identities = 61/252 (24%), Positives = 110/252 (43%), Gaps = 29/252 (11%)
Query: 34 CPTHCHCEPDGRMLL---RVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR 90
CP C+C PDG + + L L+ LP + V S +N + ++ + + SL
Sbjct: 30 CPEPCNCVPDGALRCPGPTAGLTRLSLAYLP--VKVIPSQAFRGLNEVIKIEISQIDSLE 87
Query: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ-LRHVPTEALQNLRSLQSLRLDANH 149
+E AF L +L +++QN + LR++ A NL L+ L +
Sbjct: 88 RIE-------------ANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTG 134
Query: 150 ISYVP--PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLAL--NKIHHIPDYA 205
I P FS + D+ +T IP AF+ ++ +++TL L N + +A
Sbjct: 135 IRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNN-ESVTLKLYGNGFEEVQSHA 193
Query: 206 FGNLSSLVVLHLHNN-RIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELG 263
F N ++L L L N + + F G +TLD++ L P+ + ++ L +
Sbjct: 194 F-NGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRL--IA 250
Query: 264 FHSNNIRSIPEK 275
S +++ +P +
Sbjct: 251 TSSYSLKKLPSR 262
>gi|64085121 thyroid stimulating hormone receptor isoform 1
precursor [Homo sapiens]
Length = 764
Score = 190 bits (482), Expect = 6e-48
Identities = 171/704 (24%), Positives = 306/704 (43%), Gaps = 90/704 (12%)
Query: 234 HSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF-YDNP 292
H E + ++ P+ + LK + H +R+IP AF P++ I+ D
Sbjct: 32 HQEEDFRVTCKDIQRIPSLPPSTQTLKLIETH---LRTIPSHAFSNLPNISRIYVSIDVT 88
Query: 293 IQFVGRSAFQHLPELRTLTLNGASQITEF-PD-LTGTANLESLTLTGAQISSLPQTVCNQ 350
+Q + +F +L ++ + + +T PD L L+ L + + P
Sbjct: 89 LQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVY 148
Query: 351 LPN----LQVLDLSYNLLEDLPSFS-VCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNL 405
+ L++ D Y + +F +C + + L +N ++ F L ++ L
Sbjct: 149 STDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGT-KLDAVYL 207
Query: 406 AWNK-IAIIHPNAFSTL---PSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLIS 461
NK + +I +AF + PSL LD+S +++ P GL L L L+ L
Sbjct: 208 NKNKYLTVIDKDAFGGVYSGPSL--LDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPL 265
Query: 462 SENFPELKVIEMPYAYQCCAFG------------VCENAYKISNQWNKGDNSSMDDLHK- 508
S +F L ++ Y CCAF +C + S + K N+ LH+
Sbjct: 266 SLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQE 325
Query: 509 ------------KDAGMFQAQDER--------DLEDFLLDF--------EEDLKALHS-- 538
K+ FQ + ED ++ F EE L+A S
Sbjct: 326 YEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHY 385
Query: 539 ----------VQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLY 588
+ C+P F PCE ++ +RI VW +++LAL N V + S
Sbjct: 386 DYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYK 445
Query: 589 ISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFAS 648
++ + L+ +A + G+ ++A VD +T + H W+ G GC+ GF ++FAS
Sbjct: 446 LNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFAS 505
Query: 649 ESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGA 708
E SV+ LT+ LER +++ ++ + + K I++ + +A +PL+G S Y
Sbjct: 506 ELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAK 565
Query: 709 SPLCLPLPFGEPSTMGYMVALILLNSLCFLMMTIAYTKLYCNL-----DKGDLENIWDCS 763
+CLP+ P + Y+V ++ LN + F+++ Y K+Y + + GD D
Sbjct: 566 VSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDK----DTK 621
Query: 764 MVKHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLVVVPLPACLNPLLYILF 823
+ K +A+L+FT+ I P++F + S+++N I+ K +L++ PL +C NP LY +F
Sbjct: 622 IAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIF 681
Query: 824 NPHFKEDLVSL-------RKQTYVWTRSKHPSLMSINSDDVEKQ 860
F+ D+ L ++Q + + P NS D++ Q
Sbjct: 682 TKAFQRDVFILLSKFGICKRQAQAYRGQRVPPK---NSTDIQVQ 722
>gi|31657136 follicle stimulating hormone receptor isoform 2
precursor [Homo sapiens]
Length = 633
Score = 185 bits (470), Expect = 1e-46
Identities = 153/586 (26%), Positives = 268/586 (45%), Gaps = 63/586 (10%)
Query: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI-QFVGRSAFQHLPELRTLTLNGAS 316
N EL F +R I + AF G L I N + + + F +LP+L + + A+
Sbjct: 47 NAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKAN 106
Query: 317 QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 376
+ P+ N LPNLQ L +S ++ LP L
Sbjct: 107 NLLYIN---------------------PEAFQN-LPNLQYLLISNTGIKHLPDVHKIHSL 144
Query: 377 QKI--DLRHN-EIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKLDLS- 430
QK+ D++ N I+ I+ ++F L S S+ L NK I IH AF+ L +L+LS
Sbjct: 145 QKVLLDIQDNINIHTIERNSFVGL-SFESVILWLNKNGIQEIHNCAFNGT-QLDELNLSD 202
Query: 431 SNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYK 490
+N L P HG A +I SE P C +
Sbjct: 203 NNNLEELPNDVFHG----------ASGPVILSELHP------------ICNKSILRQEVD 240
Query: 491 ISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDL-KALHSVQCSPSPGPFK 549
Q +G SS+ + + ++ R + +F+ DL + V CSP P F
Sbjct: 241 YMTQ-ARGQRSSLAEDN-------ESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFN 292
Query: 550 PCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVS 609
PCE ++ ++R+ +W I++LA+T N +V + S ++ + L+ +A ++ G+
Sbjct: 293 PCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIY 352
Query: 610 SAVLAGVDAFTFGSFARHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYS 669
++A VD T + + W+ G GC GF ++FASE SV+ LT LER ++ ++
Sbjct: 353 LLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHA 412
Query: 670 AKFETKAPFSSLKVIILLCALLALTMAAVPLLGGSKYGASPLCLPLPFGEPSTMGYMVAL 729
+ + K ++++ + A A P+ G S Y +CLP+ P + Y+++L
Sbjct: 413 MQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSL 472
Query: 730 ILLNSLCFLMMTIAYTKLYCNLDKGDL-ENIWDCSMVKHIALLLFTNCILNCPVAFLSFS 788
++LN L F+++ Y +Y + ++ + D + K +A+L+FT+ + P++F + S
Sbjct: 473 LVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAIS 532
Query: 789 SLINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSL 834
+ + + I+ K +L++ P+ +C NP LY +F +F+ D L
Sbjct: 533 ASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFIL 578
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/223 (29%), Positives = 103/223 (46%), Gaps = 39/223 (17%)
Query: 38 CHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRL 97
CHC R+ L C + ++E+PS DL N I ELR
Sbjct: 23 CHCS--NRVFL---CQESKVTEIPS---------DLPRNAI---------------ELRF 53
Query: 98 AGNALTYIPKGAFTGLYSL-KVLMLQNNQLRHVPTEALQNLRSLQSLRLD-ANHISYVPP 155
L I KGAF+G L K+ + QN+ L + + NL L +R++ AN++ Y+ P
Sbjct: 54 VLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINP 113
Query: 156 SCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN---KIHHIPDYAFGNLS-S 211
F L +L++L + + + +P + +LQ + L + IH I +F LS
Sbjct: 114 EAFQNLPNLQYLLISNTGIKHLP--DVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFE 171
Query: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLDEFPTAI 253
V+L L+ N I + F+G L+ L+L + NNL+E P +
Sbjct: 172 SVILWLNKNGIQEIHNCAFNGT-QLDELNLSDNNNLEELPNDV 213
Score = 30.8 bits (68), Expect = 6.0
Identities = 45/203 (22%), Positives = 81/203 (39%), Gaps = 27/203 (13%)
Query: 171 DNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCF 230
++ +TEIP R+ L+ + L I FG+L + + N+ + + F
Sbjct: 34 ESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQ--NDVLEVIEADVF 91
Query: 231 DGLHSLETLDLNYNN--LDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF 288
L L + + N L P A + L NL+ L + I+ +P+ + + + +
Sbjct: 92 SNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDI 151
Query: 289 YDN-PIQFVGRSAF--------------QHLPELRTLTLNGASQITEFPDLTGTANLESL 333
DN I + R++F + E+ NG +Q+ E +L+ NLE L
Sbjct: 152 QDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNG-TQLDEL-NLSDNNNLEEL 209
Query: 334 T------LTGAQISSLPQTVCNQ 350
+G I S +CN+
Sbjct: 210 PNDVFHGASGPVILSELHPICNK 232
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 170 bits (431), Expect = 5e-42
Identities = 129/427 (30%), Positives = 204/427 (47%), Gaps = 30/427 (7%)
Query: 16 LQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSM 75
L L G + +G+ GCP+ C C + V+C+ + +P+ L L +
Sbjct: 13 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ----VECTGARIVAVPTPLPWNAMSLQILN 68
Query: 76 NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
+I++L +P ++ L LR+ N L+ I GAF L SL+ L L NN+L+ +P Q
Sbjct: 69 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 128
Query: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLAL 195
L SL+SL L +N + + P+ FS +L+ L L N L IP AF L L + L
Sbjct: 129 GLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK 188
Query: 196 NKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRT 255
N + HI F +L +L VL L+ NR+ + FDG
Sbjct: 189 NSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDG----------------------- 225
Query: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
L NL+EL N I + F N +L ++ +N I + S F LP+L LTL G
Sbjct: 226 LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGN 285
Query: 316 SQITEFPDLTG-TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
S + G NL L L ISSLP V + L LQVL LS N + + +F+
Sbjct: 286 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 345
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+L+++ L N + ++ + F+ L +L++++L N++ + N F+ + L+ + L +N
Sbjct: 346 LTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 405
Query: 433 LLSSFPI 439
L + P+
Sbjct: 406 QLENLPL 412
Score = 131 bits (330), Expect = 2e-30
Identities = 85/243 (34%), Positives = 121/243 (49%), Gaps = 1/243 (0%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L+L N+++ + P L L+ LRL N LT IP G F GL +L+ L LQ NQ+ +
Sbjct: 184 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 243
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
N +LQ L L NHIS +PPS F L L L L N+L E+ + F + L+
Sbjct: 244 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 303
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
+ L N I +PD F NL L VL L N+I + F+GL L L L+ N L +
Sbjct: 304 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 363
Query: 251 -TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
R L+NL+ + +N +R +P F L+ I +N ++ + F HL +L
Sbjct: 364 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 423
Query: 310 LTL 312
L L
Sbjct: 424 LRL 426
Score = 126 bits (316), Expect = 1e-28
Identities = 103/293 (35%), Positives = 145/293 (49%), Gaps = 8/293 (2%)
Query: 174 LTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGL 233
+TE+ F ++SAL A+ + N++ I AF NL SL L L NN++ L F GL
Sbjct: 71 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 130
Query: 234 HSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292
SLE+L L+ N L + P SNLKEL H N++ IP+ AF L ++ N
Sbjct: 131 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 190
Query: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPDLT--GTANLESLTLTGAQISSLPQTVCNQ 350
+ + FQHL L+ L L +++T+ P T G NL+ L L QI L + +
Sbjct: 191 LTHISPRVFQHLGNLQVLRLY-ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 249
Query: 351 LPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
NLQ L LS N + LP F +L ++ L N + E+ + F + +LR L L N
Sbjct: 250 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 309
Query: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNH--ALQSL 459
I+ + N FS L L L LS N +S +GLT L+ H ALQ L
Sbjct: 310 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 362
Score = 108 bits (269), Expect = 3e-23
Identities = 67/175 (38%), Positives = 96/175 (54%), Gaps = 1/175 (0%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L LS N+ISQL P+ L L L L GN+L + G F + +L+ L L +N + +P
Sbjct: 256 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 315
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
NLR LQ L L N IS++ P F+GL LR L L NAL ++ FR L+ LQ
Sbjct: 316 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 375
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
++L N++ +P F N++ L+ + L NN++ +L FD L L L L Y+N
Sbjct: 376 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL-YDN 429
Score = 64.3 bits (155), Expect = 5e-10
Identities = 65/247 (26%), Positives = 95/247 (38%), Gaps = 43/247 (17%)
Query: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL-NGAS 316
N L + +I + E F+ +LI + N + + AF++L LR L+L N
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 317 QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 376
Q+ G +LESL L+ NQL +Q FS C L
Sbjct: 120 QVLPIGLFQGLDSLESLLLSS-----------NQLLQIQPAH-----------FSQCSNL 157
Query: 377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 436
+++ L N + I F L+ L LNL N + I P F L +L L L N L+
Sbjct: 158 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD 217
Query: 437 FPITGLHGLTHLK----------------LTGNHALQSLISSEN----FPELKVIEMPYA 476
P+ GL +L+ NH LQ L S N P +++P
Sbjct: 218 IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL 277
Query: 477 YQCCAFG 483
+ FG
Sbjct: 278 NRLTLFG 284
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 170 bits (431), Expect = 5e-42
Identities = 129/427 (30%), Positives = 204/427 (47%), Gaps = 30/427 (7%)
Query: 16 LQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSM 75
L L G + +G+ GCP+ C C + V+C+ + +P+ L L +
Sbjct: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQ----VECTGARIVAVPTPLPWNAMSLQILN 62
Query: 76 NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
+I++L +P ++ L LR+ N L+ I GAF L SL+ L L NN+L+ +P Q
Sbjct: 63 THITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQ 122
Query: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLAL 195
L SL+SL L +N + + P+ FS +L+ L L N L IP AF L L + L
Sbjct: 123 GLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGK 182
Query: 196 NKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRT 255
N + HI F +L +L VL L+ NR+ + FDG
Sbjct: 183 NSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDG----------------------- 219
Query: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
L NL+EL N I + F N +L ++ +N I + S F LP+L LTL G
Sbjct: 220 LVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGN 279
Query: 316 SQITEFPDLTG-TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
S + G NL L L ISSLP V + L LQVL LS N + + +F+
Sbjct: 280 SLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNG 339
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+L+++ L N + ++ + F+ L +L++++L N++ + N F+ + L+ + L +N
Sbjct: 340 LTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 399
Query: 433 LLSSFPI 439
L + P+
Sbjct: 400 QLENLPL 406
Score = 131 bits (330), Expect = 2e-30
Identities = 85/243 (34%), Positives = 121/243 (49%), Gaps = 1/243 (0%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L+L N+++ + P L L+ LRL N LT IP G F GL +L+ L LQ NQ+ +
Sbjct: 178 LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLS 237
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
N +LQ L L NHIS +PPS F L L L L N+L E+ + F + L+
Sbjct: 238 PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRE 297
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
+ L N I +PD F NL L VL L N+I + F+GL L L L+ N L +
Sbjct: 298 LWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLD 357
Query: 251 -TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
R L+NL+ + +N +R +P F L+ I +N ++ + F HL +L
Sbjct: 358 GNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCE 417
Query: 310 LTL 312
L L
Sbjct: 418 LRL 420
Score = 126 bits (316), Expect = 1e-28
Identities = 103/293 (35%), Positives = 145/293 (49%), Gaps = 8/293 (2%)
Query: 174 LTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGL 233
+TE+ F ++SAL A+ + N++ I AF NL SL L L NN++ L F GL
Sbjct: 65 ITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGL 124
Query: 234 HSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNP 292
SLE+L L+ N L + P SNLKEL H N++ IP+ AF L ++ N
Sbjct: 125 DSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNS 184
Query: 293 IQFVGRSAFQHLPELRTLTLNGASQITEFPDLT--GTANLESLTLTGAQISSLPQTVCNQ 350
+ + FQHL L+ L L +++T+ P T G NL+ L L QI L + +
Sbjct: 185 LTHISPRVFQHLGNLQVLRLY-ENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHN 243
Query: 351 LPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
NLQ L LS N + LP F +L ++ L N + E+ + F + +LR L L N
Sbjct: 244 NHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDN 303
Query: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNH--ALQSL 459
I+ + N FS L L L LS N +S +GLT L+ H ALQ L
Sbjct: 304 HISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDL 356
Score = 108 bits (269), Expect = 3e-23
Identities = 67/175 (38%), Positives = 96/175 (54%), Gaps = 1/175 (0%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L LS N+ISQL P+ L L L L GN+L + G F + +L+ L L +N + +P
Sbjct: 250 LYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLP 309
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
NLR LQ L L N IS++ P F+GL LR L L NAL ++ FR L+ LQ
Sbjct: 310 DNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQN 369
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
++L N++ +P F N++ L+ + L NN++ +L FD L L L L Y+N
Sbjct: 370 ISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL-YDN 423
Score = 64.3 bits (155), Expect = 5e-10
Identities = 65/247 (26%), Positives = 95/247 (38%), Gaps = 43/247 (17%)
Query: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL-NGAS 316
N L + +I + E F+ +LI + N + + AF++L LR L+L N
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 317 QITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKL 376
Q+ G +LESL L+ NQL +Q FS C L
Sbjct: 114 QVLPIGLFQGLDSLESLLLSS-----------NQLLQIQPAH-----------FSQCSNL 151
Query: 377 QKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSS 436
+++ L N + I F L+ L LNL N + I P F L +L L L N L+
Sbjct: 152 KELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTD 211
Query: 437 FPITGLHGLTHLK----------------LTGNHALQSLISSEN----FPELKVIEMPYA 476
P+ GL +L+ NH LQ L S N P +++P
Sbjct: 212 IPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQL 271
Query: 477 YQCCAFG 483
+ FG
Sbjct: 272 NRLTLFG 278
>gi|18677729 relaxin/insulin-like family peptide receptor 2 [Homo
sapiens]
Length = 754
Score = 152 bits (384), Expect = 1e-36
Identities = 164/645 (25%), Positives = 271/645 (42%), Gaps = 96/645 (14%)
Query: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNI 269
+++ +L L N+IHSL K F + Y + LK++ N I
Sbjct: 137 NNVTLLSLKKNKIHSLPDKVF----------IKY-------------TKLKKIFLQHNCI 173
Query: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGT 327
R I KAF G +L ++ N I + F+ L +L L L+ + IT TG
Sbjct: 174 RHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDD-NPITRISQRLFTGL 232
Query: 328 ANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNE 385
+L L++ + +LP+ +C Q+P L +DL N ++ L + F C L + L N+
Sbjct: 233 NSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQ 292
Query: 386 IYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGL 445
I + TF L +L L+L+ N I + P+ F L L KL+LSSN P+ LH
Sbjct: 293 IGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSN-----PLMYLHKN 347
Query: 446 THLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDD 505
L LQSL +L+ IE+P
Sbjct: 348 QFESLK---QLQSL-------DLERIEIPNI----------------------------- 368
Query: 506 LHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVW 565
+ MFQ + +F A H C P E LL ++RI VW
Sbjct: 369 ----NTRMFQPMKNLS-HIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVW 423
Query: 566 TIAVLALTCNALVTSTVFRSPLYISPIKLLIGVIAAVNMLTGVSSAVLAGVDAFTFGSFA 625
IA + N V + + I ++ + L GV + D G +
Sbjct: 424 VIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQ 483
Query: 626 RHGAWWENGVGCHVIGFLSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVII 685
++ W V C ++GFL++ ++E SV LLT LE+ + + F P +I
Sbjct: 484 KYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVF--PFSNIRPGKRQTSVI 541
Query: 686 LLCALLA-LTMAAVPLLG----GSKYGASPLCLPLPFGEP---STMGYMVALIL-LNSLC 736
L+C +A +A +P G+ YG + +C PL + + + GY + + L +N L
Sbjct: 542 LICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLA 601
Query: 737 FLMMTIAYTKLYCNLDKGDLE--NIWDC-----SMVKHIALLLFTNCILNCPVAFLSFSS 789
FL++ +Y ++C++ K L+ + +C ++ ++F++ I PV + S
Sbjct: 602 FLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILS 661
Query: 790 LINLTFISPEVIKFILLVVVPLPACLNPLLYILFNPHFKEDLVSL 834
L + I + +I++ +P+ + LNP+LY L FK+ L L
Sbjct: 662 LFRVE-IPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQL 705
Score = 89.4 bits (220), Expect = 1e-17
Identities = 75/278 (26%), Positives = 127/278 (45%), Gaps = 7/278 (2%)
Query: 31 LRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR 90
L+ P C C+ ++C + L +P +S + L L N I L
Sbjct: 108 LKQYPQCCDCKET-----ELECVNGDLKSVPM-ISNNVTLLSLKKNKIHSLPDKVFIKYT 161
Query: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
L+++ L N + +I + AF GL +L++L L +N + + ++L L L LD N I
Sbjct: 162 KLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPI 221
Query: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLS 210
+ + F+GL+SL L + +N L +P Q + L + L N+I ++ + F +
Sbjct: 222 TRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCD 281
Query: 211 SLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNI 269
SL VL L N+I + +K F L +L LDL+ N + E P + L L++L SN +
Sbjct: 282 SLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPL 341
Query: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPEL 307
+ + F L ++ I + FQ + L
Sbjct: 342 MYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNL 379
Score = 83.2 bits (204), Expect = 1e-15
Identities = 62/195 (31%), Positives = 93/195 (47%), Gaps = 1/195 (0%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L L+ N I+ L P L L L L N +T I + FTGL SL L + NN L +P
Sbjct: 190 LYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALP 249
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
+ + L + L+ N I Y+ S F SL L+L N + +P + F SL L
Sbjct: 250 KQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGE 309
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
+ L+ N I + + F +L L L+L +N + L K F+ L L++LDL +
Sbjct: 310 LDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNIN 369
Query: 251 TAI-RTLSNLKELGF 264
T + + + NL + F
Sbjct: 370 TRMFQPMKNLSHIYF 384
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/182 (30%), Positives = 85/182 (46%), Gaps = 15/182 (8%)
Query: 75 MNNISQLLPNPL----PSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
+NN + LP + P L +++ L GN + Y+ F SL VL L NQ+ VP
Sbjct: 241 VNNYLEALPKQMCAQMPQLNWVD---LEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVP 297
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
+ +L++L L L +N I+ + P F L L+ L L N L + F SL LQ+
Sbjct: 298 EKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQS 357
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG---KKCF---DGLHSLETLDLNYN 244
+ L +I +I F + +L ++ N R S + C DG+ S E DL N
Sbjct: 358 LDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFE--DLLAN 415
Query: 245 NL 246
N+
Sbjct: 416 NI 417
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 150 bits (380), Expect = 4e-36
Identities = 122/367 (33%), Positives = 173/367 (47%), Gaps = 10/367 (2%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L+L N+++ L L L EL LAGN L Y+ F+GL L+ L L N LR +
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
L LQ L LD N I+ V P F GL +LR L L N + + F L L+
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
+ L+ N I + F +L L L L +NRI L ++ F+GL LE L L++N L E
Sbjct: 333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 392
Query: 251 T-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
A L+N+ + N +R++PE+ F G L ++H + + + F L LR
Sbjct: 393 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 452
Query: 310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
L L NG I E L G A L L LT Q++ LP + L L+ L LS N L +L
Sbjct: 453 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 511
Query: 368 PSFSV--CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
P+ ++ Q+ +D+ HN + + L LR L+L N + P P L
Sbjct: 512 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLE 567
Query: 426 KLDLSSN 432
+L L N
Sbjct: 568 RLWLEGN 574
Score = 148 bits (373), Expect = 3e-35
Identities = 145/463 (31%), Positives = 205/463 (44%), Gaps = 17/463 (3%)
Query: 7 GVLLSLPVLLQLATG-----GSSPRSGVLLRG--CPTHCHCE-PDGRMLLRVDCSDLGLS 58
G+ L+L +L +A G G+ P + G CP C C D L V CS L+
Sbjct: 45 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 104
Query: 59 ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKV 118
LP + T L L NN+S + P +L L L L G L + A GL +L
Sbjct: 105 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 164
Query: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178
L L+ NQLR + + +L SL L N +S + F GL SL L L N+L +P
Sbjct: 165 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 224
Query: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238
AFR L +L+ + LA N++ ++ F L+ L L L N + ++ F L L+
Sbjct: 225 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 284
Query: 239 LDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
L L+ N + P A L L+ L N + + E F G L + N I +
Sbjct: 285 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 344
Query: 298 RSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
F+ L L L L N Q+ E G LE LTL Q+ + L N+
Sbjct: 345 PRTFKDLHFLEELQLGHNRIRQLAE-RSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
Query: 356 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413
V++LS N L +LP F KL + L + + I+ TF L LR L L N + I
Sbjct: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463
Query: 414 HPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
+ L L++LDL+SN L+ P GL L +L L+ N
Sbjct: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 506
Score = 106 bits (264), Expect = 1e-22
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 1/206 (0%)
Query: 67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
F L L N I QL L LE L L N L + GAF GL ++ V+ L N L
Sbjct: 353 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Query: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
R++P + + L L SL L+ + + + P F+GL LR L+L DN L I Q+ L+
Sbjct: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 472
Query: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
L + L N++ H+P F L L L L NR+ L L LD+++N L
Sbjct: 473 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 532
Query: 247 DEFPTA-IRTLSNLKELGFHSNNIRS 271
+ P + + L L+ L +N++R+
Sbjct: 533 EALPNSLLAPLGRLRYLSLRNNSLRT 558
Score = 100 bits (250), Expect = 5e-21
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 4/269 (1%)
Query: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
+LDLS N ++ LL + P L L LRL+ NA+ + F L+ L+ L L +N++R +
Sbjct: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367
Query: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
+ + L L+ L LD N + V F GL ++ + L N L +P Q FR L L
Sbjct: 368 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 427
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
++ L + + I + F LS L L L +N + + ++ GL L LDL N L
Sbjct: 428 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 487
Query: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
P + + L L+ L N + +P A + N ++ + S L LR
Sbjct: 488 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 547
Query: 309 TLTLNGASQITEFPDLTGTANLESLTLTG 337
L+L S T P G LE L L G
Sbjct: 548 YLSLRNNSLRTFTPQPPG---LERLWLEG 573
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 150 bits (380), Expect = 4e-36
Identities = 122/367 (33%), Positives = 173/367 (47%), Gaps = 10/367 (2%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L+L N+++ L L L EL LAGN L Y+ F+GL L+ L L N LR +
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
L LQ L LD N I+ V P F GL +LR L L N + + F L L+
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
+ L+ N I + F +L L L L +NRI L ++ F+GL LE L L++N L E
Sbjct: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
Query: 251 T-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
A L+N+ + N +R++PE+ F G L ++H + + + F L LR
Sbjct: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
Query: 310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
L L NG I E L G A L L LT Q++ LP + L L+ L LS N L +L
Sbjct: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
Query: 368 PSFSV--CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
P+ ++ Q+ +D+ HN + + L LR L+L N + P P L
Sbjct: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLE 529
Query: 426 KLDLSSN 432
+L L N
Sbjct: 530 RLWLEGN 536
Score = 148 bits (373), Expect = 3e-35
Identities = 145/463 (31%), Positives = 205/463 (44%), Gaps = 17/463 (3%)
Query: 7 GVLLSLPVLLQLATG-----GSSPRSGVLLRG--CPTHCHCE-PDGRMLLRVDCSDLGLS 58
G+ L+L +L +A G G+ P + G CP C C D L V CS L+
Sbjct: 7 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 66
Query: 59 ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKV 118
LP + T L L NN+S + P +L L L L G L + A GL +L
Sbjct: 67 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 126
Query: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178
L L+ NQLR + + +L SL L N +S + F GL SL L L N+L +P
Sbjct: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186
Query: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238
AFR L +L+ + LA N++ ++ F L+ L L L N + ++ F L L+
Sbjct: 187 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 246
Query: 239 LDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
L L+ N + P A L L+ L N + + E F G L + N I +
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306
Query: 298 RSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
F+ L L L L N Q+ E G LE LTL Q+ + L N+
Sbjct: 307 PRTFKDLHFLEELQLGHNRIRQLAE-RSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
Query: 356 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413
V++LS N L +LP F KL + L + + I+ TF L LR L L N + I
Sbjct: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
Query: 414 HPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
+ L L++LDL+SN L+ P GL L +L L+ N
Sbjct: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
Score = 106 bits (264), Expect = 1e-22
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 1/206 (0%)
Query: 67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
F L L N I QL L LE L L N L + GAF GL ++ V+ L N L
Sbjct: 315 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Query: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
R++P + + L L SL L+ + + + P F+GL LR L+L DN L I Q+ L+
Sbjct: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
Query: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
L + L N++ H+P F L L L L NR+ L L LD+++N L
Sbjct: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
Query: 247 DEFPTA-IRTLSNLKELGFHSNNIRS 271
+ P + + L L+ L +N++R+
Sbjct: 495 EALPNSLLAPLGRLRYLSLRNNSLRT 520
Score = 100 bits (250), Expect = 5e-21
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 4/269 (1%)
Query: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
+LDLS N ++ LL + P L L LRL+ NA+ + F L+ L+ L L +N++R +
Sbjct: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
Query: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
+ + L L+ L LD N + V F GL ++ + L N L +P Q FR L L
Sbjct: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
++ L + + I + F LS L L L +N + + ++ GL L LDL N L
Sbjct: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
Query: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
P + + L L+ L N + +P A + N ++ + S L LR
Sbjct: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
Query: 309 TLTLNGASQITEFPDLTGTANLESLTLTG 337
L+L S T P G LE L L G
Sbjct: 510 YLSLRNNSLRTFTPQPPG---LERLWLEG 535
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 147 bits (372), Expect = 3e-35
Identities = 131/434 (30%), Positives = 206/434 (47%), Gaps = 22/434 (5%)
Query: 8 VLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVF 67
+L L + L+ T + PR+ C C C D +DC GL+ LP +L +
Sbjct: 20 LLWLLLLRLEPVTAAAGPRAP-----CAAACTCAGDS-----LDCGGRGLAALPGDLPSW 69
Query: 68 TSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLR 127
T L+LS N +S++ P L L+E+ L N LT +P + + L LQ+N++R
Sbjct: 70 TRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVS-LFLQHNKIR 128
Query: 128 HVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS- 186
V L+ SL+ L L N+I+ V +CF ++ L L N + + + AF LS
Sbjct: 129 SVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSR 188
Query: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
+L + L+ N+I +P AF L L L L+ NRI + F GL+SLE L L NN+
Sbjct: 189 SLLTLRLSKNRITQLPVRAF-KLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNI 247
Query: 247 DEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLP 305
+ A LS + L N++ + + G +L +H +N I + R +
Sbjct: 248 SKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQ 307
Query: 306 ELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYN- 362
+L L L N +++ E L ++L L L+ IS + + L +L+VLDL +N
Sbjct: 308 KLHELVLSFNNLTRLDE-ESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNE 366
Query: 363 ---LLEDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
+ED +FS L K+ L N+I + F L L LNL N I + +AF
Sbjct: 367 ISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAF 426
Query: 419 STLPSLIKLDLSSN 432
+ +L +L +SS+
Sbjct: 427 VKMKNLKELHISSD 440
Score = 48.5 bits (114), Expect = 3e-05
Identities = 55/176 (31%), Positives = 79/176 (44%), Gaps = 23/176 (13%)
Query: 47 LLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYI- 105
L R+D + L+EL S+LSV L LS N+IS + LR L L L N ++
Sbjct: 319 LTRLD--EESLAEL-SSLSV----LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTI 371
Query: 106 --PKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHS 163
GAF+GL SL L L N+++ V A L L+ L L N I V F + +
Sbjct: 372 EDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN 431
Query: 164 LRHL------WLDDNALTEIP-------VQAFRSLSALQAMTLALNKIHHIPDYAF 206
L+ L +L D L +P +QAF + + +L I +P +F
Sbjct: 432 LKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIFSVPPESF 487
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 146 bits (369), Expect = 7e-35
Identities = 125/404 (30%), Positives = 184/404 (45%), Gaps = 79/404 (19%)
Query: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
GC + C GR +++C +LGLS +P N T +L L+ NNIS
Sbjct: 31 GCSSVCQL-CTGR---QINCRNLGLSSIPKNFPESTVFLYLTGNNIS------------- 73
Query: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
YI + TGL+SL L L N+ + +V +A LR L L L+ N I
Sbjct: 74 -----------YINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKR 122
Query: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
+ P F GL +LR+L+L N++ +P F +L S+
Sbjct: 123 LDPGIFKGLLNLRNLYLQ------------------------YNQVSFVPRGVFNDLVSV 158
Query: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP-TAIRTLSNLKELGFHSNNIRS 271
L+L NR+ LG F G+ +L LDL+ NN+ + + L NL L SNN+
Sbjct: 159 QYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTK 218
Query: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
+P AF SL + NPI+ + AF+ G ANLE
Sbjct: 219 VPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK-----------------------GLANLE 255
Query: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEI 389
L L ++I ++ + + + NL+ L LS+N LE+L S FS+ + L + L N I I
Sbjct: 256 YLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISI 315
Query: 390 KVDTFQQL-LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
DTF+ + SL+ LNL++N + +HP L SLI L +SN
Sbjct: 316 DNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Score = 75.1 bits (183), Expect = 3e-13
Identities = 63/186 (33%), Positives = 88/186 (47%), Gaps = 3/186 (1%)
Query: 267 NNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDL-T 325
NNI I E G SL+ ++ ++ I +V AF L L L LN P +
Sbjct: 70 NNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFK 129
Query: 326 GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRH 383
G NL +L L Q+S +P+ V N L ++Q L+L N L L S F L+ +DL +
Sbjct: 130 GLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSN 189
Query: 384 NEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLH 443
N I I FQ L +L L L N + + NAF L SL +L LS N + +
Sbjct: 190 NNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFK 249
Query: 444 GLTHLK 449
GL +L+
Sbjct: 250 GLANLE 255
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 145 bits (367), Expect = 1e-34
Identities = 151/622 (24%), Positives = 260/622 (41%), Gaps = 85/622 (13%)
Query: 235 SLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI 293
++ + L +N + + P + +L++L +N I SI AF G SL ++ N I
Sbjct: 127 NVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRI 186
Query: 294 QFVGRSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLP-QTVCNQ 350
F+ F+ L L L + N S+I+ P G +L L L ++ LP + +C
Sbjct: 187 TFLKPGVFEDLHRLEWLIIEDNHLSRISP-PTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
Query: 351 LPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
+P L LDL N + +L + F C L + +R N+I + +TF L L L+L N
Sbjct: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
Query: 409 KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQ-SLISSENFPE 467
KI + P F L L +L+LS N + L LK ++ S I F
Sbjct: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRP 365
Query: 468 LKVIEMPY--AYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDF 525
L + Y +Q C +
Sbjct: 366 LMNLSHIYFKKFQYCGY------------------------------------------- 382
Query: 526 LLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIRIGVWTIAVLALTCNALVTSTVFRS 585
A H C P+ E+LL + R+ VW ++ A+TC + R
Sbjct: 383 ---------APHVRSCKPNTDGISSLENLLASIIQRVFVWVVS--AVTCFGNIFVICMR- 430
Query: 586 PLYISPIKLL---IGVIAAVNMLTGVSSAVLAGVDAFTFGSFARHGAWWENGVGCHVIGF 642
P S KL I + + L G+ V+ G D G + +H W C ++G
Sbjct: 431 PYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGS 490
Query: 643 LSIFASESSVFLLTLAALERGFSVKYSAKFETKAPFSSLKVIILLCALLALTMAAVPLLG 702
L+I ++E SV LLT LE+ + Y + ++ V+IL+ + +A +PL
Sbjct: 491 LAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIW-ITGFIVAFIPLSN 549
Query: 703 ----GSKYGASPLCLPLPFGEPSTMG---YMVALIL-LNSLCFLMMTIAYTKLYCNLDKG 754
+ YG + +C PL + ++G Y VA+ L +N F+++ +Y ++ ++ +
Sbjct: 550 KEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQS 609
Query: 755 -----DLENIWDCSMV--KHIALLLFTNCILNCPVAFLSFSSLINLTFISPEVIKFILLV 807
++ N M+ K ++FT+ + P+ + F SL+ + I + ++++
Sbjct: 610 AITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVE-IPGTITSWVVIF 668
Query: 808 VVPLPACLNPLLYILFNPHFKE 829
++P+ + LNP+LY L FKE
Sbjct: 669 ILPINSALNPILYTLTTRPFKE 690
Score = 102 bits (253), Expect = 2e-21
Identities = 78/287 (27%), Positives = 122/287 (42%), Gaps = 32/287 (11%)
Query: 30 LLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSL 89
L+ P C C+ L +DC + L +PS S T+
Sbjct: 96 LVGSVPVQCLCQG-----LELDCDETNLRAVPSVSSNVTA-------------------- 130
Query: 90 RFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANH 149
+ L N + +P F + L+ L LQNN++ + A + L SL L L N
Sbjct: 131 -----MSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNR 185
Query: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAF-GN 208
I+++ P F LH L L ++DN L+ I F L++L + L N + +PD +
Sbjct: 186 ITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQH 245
Query: 209 LSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSN 267
+ L L L N IH+L F +L L + N ++ L L EL SN
Sbjct: 246 MPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSN 305
Query: 268 NIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNG 314
I ++P F L ++ NPIQ + + F +L +L++L+L G
Sbjct: 306 KIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEG 352
Score = 94.4 bits (233), Expect = 4e-19
Identities = 81/315 (25%), Positives = 137/315 (43%), Gaps = 31/315 (9%)
Query: 126 LRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSL 185
LR VP+ + ++ ++ L N I +PP CF H L+ L+L +N +T I + AFR L
Sbjct: 118 LRAVPSVS----SNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGL 173
Query: 186 SALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN 245
++L + L+ N+I + F +L L L + +N + + F GL+SL L L N
Sbjct: 174 NSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNV 233
Query: 246 LDEFP--TAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQH 303
L P + + L L N+I ++ F+ +L + N I + + F
Sbjct: 234 LTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAP 293
Query: 304 LPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNL 363
L + L+ L L +I +LP + L L L+LSYN
Sbjct: 294 LQK-----------------------LDELDLGSNKIENLPPLIFKDLKELSQLNLSYNP 330
Query: 364 LEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTL 421
++ + + F KL+ + L EI I+ F+ L++L + + P+ S
Sbjct: 331 IQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCK 390
Query: 422 PSLIKLDLSSNLLSS 436
P+ + NLL+S
Sbjct: 391 PNTDGISSLENLLAS 405
Score = 45.8 bits (107), Expect = 2e-04
Identities = 47/178 (26%), Positives = 73/178 (41%), Gaps = 34/178 (19%)
Query: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
+LDL N+I L LT+I +L VL+++ N++ H+
Sbjct: 251 WLDLEGNHIHNL------------------RNLTFI------SCSNLTVLVMRKNKINHL 286
Query: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
L+ L L L +N I +PP F L L L L N + +I F L L+
Sbjct: 287 NENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLK 346
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLG--------KKCFDGLHSLETL 239
+++L +I +I F L +L H++ + G K DG+ SLE L
Sbjct: 347 SLSLEGIEISNIQQRMFRPLMNL--SHIYFKKFQYCGYAPHVRSCKPNTDGISSLENL 402
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 145 bits (366), Expect = 2e-34
Identities = 117/358 (32%), Positives = 170/358 (47%), Gaps = 12/358 (3%)
Query: 9 LLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFT 68
+LSLP+LL A + P +G GCP C C R V C+ L+ +P + T
Sbjct: 7 VLSLPLLLLPA---APPPAG----GCPARCECTVQTRA---VACTRRRLTAVPDGIPAET 56
Query: 69 SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
L+LS N I L P L +L LEEL L+ NA+ ++ GAF L L+VL L+ NQL+
Sbjct: 57 RLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKL 116
Query: 129 VPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSAL 188
+P L +L L L N + + F LHSLR L + DN L + +AF L AL
Sbjct: 117 IPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLAL 176
Query: 189 QAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLD 247
+ +TL + + + G+L SL L L + I SL + F L L L++ N+ L+
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 248 EFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPEL 307
E NL L NI ++P A L ++ NPI V R +F+ L L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
Query: 308 RTLTLNGA-SQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
R L L GA + E G + L L+ +S+L ++ + + L+ L + N L
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 104 bits (259), Expect = 4e-22
Identities = 104/360 (28%), Positives = 163/360 (45%), Gaps = 60/360 (16%)
Query: 102 LTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGL 161
LT +P G ++L L N++R + L L +L+ L L N I++V P F+ L
Sbjct: 45 LTAVPDGIPA---ETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANL 101
Query: 162 HSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNR 221
LR L L N L IP F L L + L+ NK+ + DY F +L SL L + +N
Sbjct: 102 PRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDND 161
Query: 222 IHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI--RTLSNLKELG---FHSNNIRSIPEKA 276
+ + ++ F GL +LE L L NL TA+ +L +L+ LG I S+ ++
Sbjct: 162 LVFVSRRAFAGLLALEELTLERCNL----TALSGESLGHLRSLGALRLRHLAIASLEDQN 217
Query: 277 FVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLT 336
F P L+ + + P+ L E+ +L G NL SL++T
Sbjct: 218 FRRLPGLLHLEIDNWPL----------LEEVAAGSLRGL-------------NLTSLSVT 254
Query: 337 GAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQ 396
I+++P +L L+LS+N + +P S F+
Sbjct: 255 HTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGS----------------------FRD 292
Query: 397 LLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHG---LTHLKLTGN 453
L+ LR L+LA +A++ P AF L + L+LS+NLLS+ + H L L++ GN
Sbjct: 293 LVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGN 352
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/81 (34%), Positives = 43/81 (53%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L+LS N IS + L L EL LAG L + AF GL +++L L NN L +
Sbjct: 275 LNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLE 334
Query: 131 TEALQNLRSLQSLRLDANHIS 151
++ +L++LR+D N ++
Sbjct: 335 ESTFHSVNTLETLRVDGNPLA 355
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 139 bits (351), Expect = 9e-33
Identities = 133/452 (29%), Positives = 203/452 (44%), Gaps = 47/452 (10%)
Query: 18 LATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNN 77
L P G CP C C +G VDC + L E P +L T++L L N
Sbjct: 100 LVLSPEEPGPGPAAVSCPRDCACSQEGV----VDCGGIDLREFPGDLPEHTNHLSLQNNQ 155
Query: 78 ISQLLPNPLPSLRFLEELRLAGNALTY--IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
+ ++ P L L LE L L N LT +P+ AF L +L L L NN+L P L
Sbjct: 156 LEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAP-RFLP 214
Query: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTE--IPVQAFRSLSALQAMTL 193
N +L S+ AN+++ + F +LR ++L +N L + +P F S ++ + L
Sbjct: 215 N--ALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLIL 272
Query: 194 ALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAI 253
+ N + H+P + +L LHL NN++ + F L SL L L N L +
Sbjct: 273 SSNFLRHVPKHL---PPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDN 329
Query: 254 RT---LSNLKELGFHSNNIRSIPEKAFVGNP-SLITIHFYDNPIQFVGRSAFQHLPELRT 309
T LS+L+ L SNN+ +P G P SL+ +H N I+ V + + L
Sbjct: 330 ETFWKLSSLEYLDLSSNNLSRVP----AGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEY 385
Query: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
L L+ ++Q+ E + L G L L + L N LE +PS
Sbjct: 386 LLLH-SNQLRE-------QGIHPLAFQG-------------LKRLHTVHLYNNALERVPS 424
Query: 370 FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI--IHPNAFSTLPSLIKL 427
+ ++++ + + HN+I I + F L LNL++N+I +H +AF L L L
Sbjct: 425 -GLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
Query: 428 DLSSNLLSSFPITGLHGLTHLKLTGNHALQSL 459
DLS N L + P GL H+ + L +L
Sbjct: 484 DLSGNRLHTLP-PGLPRNVHVLKVKRNELAAL 514
Score = 70.5 bits (171), Expect = 7e-12
Identities = 63/218 (28%), Positives = 103/218 (47%), Gaps = 13/218 (5%)
Query: 57 LSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALT--YIPKGAFTGLY 114
L +PS L L + N I+ + + FLEEL L+ N +T + + AF L
Sbjct: 419 LERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLR 478
Query: 115 SLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
L+ L L N+L +P +N+ L+ R N ++ + G+ LR L+L N L
Sbjct: 479 LLRSLDLSGNRLHTLPPGLPRNVHVLKVKR---NELAALARGALVGMAQLRELYLTSNRL 535
Query: 175 TE--IPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDG 232
+ +A+ L+ LQ + +A N++ IP+ G SL L+L NN+I ++ FD
Sbjct: 536 RSRALGPRAWVDLAHLQLLDIAGNQLTEIPE---GLPESLEYLYLQNNKISAVPANAFDS 592
Query: 233 LHSLETLDLNYNNL---DEFPTAIRTLSNLKELGFHSN 267
+L+ + L +N L +A R L +L+ L N
Sbjct: 593 TPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 139 bits (350), Expect = 1e-32
Identities = 115/407 (28%), Positives = 185/407 (45%), Gaps = 14/407 (3%)
Query: 34 CPTHCHCE-PDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
CP C C D D + + LP+NL T L M L + L
Sbjct: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNL---THILLFGMGR-GVLQSQSFSGMTVL 76
Query: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
+ L ++ + ++ + G F+ L LK L L N++ H+P L + L+ L LD N +
Sbjct: 77 QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG 136
Query: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
+ + F L +L+ L L+ N L +P F +L L+ + L+ N + H+P G + L
Sbjct: 137 IDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196
Query: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRS 271
L LH+NR+ SL + L +L L + N++ P A L NL L N++
Sbjct: 197 ERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
Query: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
+P F+ + +L + ++NP+ + F + L+ L LN +Q+ P NL
Sbjct: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN-RTQLRTLP-AAAFRNLS 314
Query: 332 SLTLTGA----QISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSV--CQKLQKIDLRHNE 385
L G ++S+LPQ L LQVL L N L LP + KL+++ LR N
Sbjct: 315 RLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNR 374
Query: 386 IYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+ + F+ L SL S+ L N++ + + F LP L ++ L N
Sbjct: 375 LRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 65.1 bits (157), Expect = 3e-10
Identities = 72/263 (27%), Positives = 106/263 (40%), Gaps = 40/263 (15%)
Query: 207 GNLSSLVVLHLHNNRIHSL---------GKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256
G+++ + L L N H L + F G+ L+ L ++ +++ P L
Sbjct: 38 GDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDL 97
Query: 257 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYD-NPIQFVGRSAFQHLPELRTLTLNGA 315
LK L N I +P A + L+ F D N ++ + ++ FQ L
Sbjct: 98 IKLKTLRLSRNKITHLPG-ALLDKMVLLEQLFLDHNALRGIDQNMFQKL----------- 145
Query: 316 SQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVC 373
NL+ L L Q+ LP ++ L NL++LDLS N L LP
Sbjct: 146 ------------VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQ 193
Query: 374 QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNL 433
KL+++ L N + + L +L L N I I P AF LP+L L LS N
Sbjct: 194 AKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNH 253
Query: 434 LSSFP---ITGLHGLTHLKLTGN 453
L+ P H LT L L N
Sbjct: 254 LAFLPSALFLHSHNLTLLTLFEN 276
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/105 (33%), Positives = 55/105 (52%), Gaps = 1/105 (0%)
Query: 70 YLDLSMN-NISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
YL ++++ +S L L L+ L L N LT +P G GL L+ + L+ N+LR
Sbjct: 318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRA 377
Query: 129 VPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNA 173
+P +NL SL+S++LD N + +P F L L + L N+
Sbjct: 378 LPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 135 bits (341), Expect = 1e-31
Identities = 126/414 (30%), Positives = 206/414 (49%), Gaps = 23/414 (5%)
Query: 32 RGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRF 91
R CPT C C D +DCS L+ LP L + + LDLS N +S + + + L+
Sbjct: 45 RPCPTTCRCLGD-----LLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQS 99
Query: 92 LEELRLAGNALTYIPK-GAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
L E++L N L IP G + ++ +L L N++ + E L+ +SL++L L +N+I
Sbjct: 100 LREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
Query: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSL-SALQAMTLALNKIHHIPDYAFGNL 209
S + + F L L++L+L+ N +T + F +L + L + L N+I IP F L
Sbjct: 158 SEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KL 214
Query: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDE-FPTAIRTLSNLKELGFHSNN 268
L L L+ N+I ++ F GL +L++L + N + + A LSN++ L NN
Sbjct: 215 PQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNN 274
Query: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAF---QHLPELRTLTLNGASQITEFPDLT 325
+ I + G L +H N I + A+ Q L EL LT N S++ +
Sbjct: 275 LTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL-DLTFNHLSRLDD-SSFL 332
Query: 326 GTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYN----LLEDL-PSFSVCQKLQKID 380
G + L +L + ++S + L +L+ LDL N +ED+ +FS KL+++
Sbjct: 333 GLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLI 392
Query: 381 LRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLL 434
L+ N I I F L +L L+L+ N I + NAFS + L +L L+++ L
Sbjct: 393 LQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 117 bits (293), Expect = 5e-26
Identities = 96/316 (30%), Positives = 144/316 (45%), Gaps = 25/316 (7%)
Query: 63 NLSVFTSYLDLSMNNISQLLPN--PLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLM 120
NL+ L L+ N IS + P LP L+ LE L N + + F GL +LK L
Sbjct: 189 NLANTLLVLKLNRNRISAIPPKMFKLPQLQHLE---LNRNKIKNVDGLTFQGLGALKSLK 245
Query: 121 LQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQ 180
+Q N + + A L +++ L+LD N+++ + GL L+ L L NA+ I
Sbjct: 246 MQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPD 305
Query: 181 AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLD 240
A+ L + L N + + D +F LS L LH+ NNR+ + F GL SL+TLD
Sbjct: 306 AWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLD 365
Query: 241 LNYN----NLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV 296
L N +++ A L L+ L N IRSI +KAF G +L + DN I +
Sbjct: 366 LKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSL 425
Query: 297 GRSAFQHLPELRTLTLNGAS-----QITEFPDLTGTANLESLT---------LTGAQISS 342
+AF + +L+ L LN +S Q+ P N +S L G I +
Sbjct: 426 QGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFA 485
Query: 343 LPQT--VCNQLPNLQV 356
+ VC+ P Q+
Sbjct: 486 VSPDGFVCDDFPKPQI 501
Score = 36.2 bits (82), Expect = 0.14
Identities = 36/113 (31%), Positives = 46/113 (40%), Gaps = 26/113 (23%)
Query: 346 TVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRS--- 402
T C L +L LD S L LP + + ++DL HN + IK + L SLR
Sbjct: 49 TTCRCLGDL--LDCSRKRLARLPE-PLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKL 105
Query: 403 --------------------LNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
L+LA N+I I P SL LDLSSN +S
Sbjct: 106 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS 158
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 135 bits (341), Expect = 1e-31
Identities = 122/413 (29%), Positives = 183/413 (44%), Gaps = 45/413 (10%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP C C VDC GL +P N+ T L+L+ NNI+++ N L+ L
Sbjct: 34 CPALCTCTGT-----TVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLR 88
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
L+L N + + +GAF + L+ L L NQL +P QN ++L L L N I +
Sbjct: 89 VLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAI 148
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
P F G L++L LD N ++ I AFR+L L+ +TL N I IP +F ++ L
Sbjct: 149 PRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLR 208
Query: 214 VLHLHNNRIH------------------SLGKKCFDGLHSLETLDLNYNNLDEF------ 249
LH+N + L +C G SL L++ EF
Sbjct: 209 TFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQC-SGPASLRGLNVAEVQKSEFSCSGQG 267
Query: 250 -----PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNP-----SLITIHFYDNPIQFVGRS 299
PT + + + SN I K P ++ I N I+ +
Sbjct: 268 EAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPG 327
Query: 300 AFQHLPELRTLTLNGASQITEF-PD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVL 357
AF +LR + L+ +QI E PD G +L SL L G +I+ LP+ V L LQ+L
Sbjct: 328 AFSPYRKLRRIDLSN-NQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLL 386
Query: 358 DLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWN 408
L+ N + + +F Q L + L N+I + TF L ++++L+LA N
Sbjct: 387 LLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Score = 112 bits (279), Expect = 2e-24
Identities = 119/435 (27%), Positives = 179/435 (41%), Gaps = 57/435 (13%)
Query: 22 GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL 81
G P + CP C C VDC GL+ +P+NL + + L +N I +
Sbjct: 270 GRVPTCTLSSGSCPAMCTCSNG-----IVDCRGKGLTAIPANLPETMTEIRLELNGIKSI 324
Query: 82 LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
P R L + L+ N + I AF GL SL L+L N++ +P L +LQ
Sbjct: 325 PPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQ 384
Query: 142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN----- 196
L L+AN I+ + P F L +L L L DN + + F SL A+Q + LA N
Sbjct: 385 LLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICD 444
Query: 197 -KIHHIPDYAFGN------LSSLVVLHLHNNRIHSLGKKCFD-------GLHSLETLDLN 242
+ + D+ N L N RI + K F + E LN
Sbjct: 445 CNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLN 504
Query: 243 --YNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV-GRS 299
N+ P R +N+ E S + IPE+ S + +N I +
Sbjct: 505 SECNSDVVCPHKCRCEANVVECS--SLKLTKIPERI---PQSTAELRLNNNEISILEATG 559
Query: 300 AFQHLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVL 357
F+ L L+ + L+ ++++E D G A++ L LT Q+ S+ + L L+ L
Sbjct: 560 MFKKLTHLKKINLSN-NKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTL 618
Query: 358 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNA 417
LR+N I I D+F L ++R L+L N+I + P A
Sbjct: 619 ----------------------MLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGA 656
Query: 418 FSTLPSLIKLDLSSN 432
F TL SL L+L +N
Sbjct: 657 FDTLQSLSTLNLLAN 671
Score = 99.8 bits (247), Expect = 1e-20
Identities = 99/364 (27%), Positives = 162/364 (44%), Gaps = 35/364 (9%)
Query: 138 RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNK 197
R+ + L L+ N+I+ + + F+GL LR L L +N + + AF + L+ + L N+
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 198 IHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTL 256
+H +P+ F N +L L L N I ++ +K F G L+ L L+ N + A R L
Sbjct: 121 LHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL 180
Query: 257 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAF--QHLPELRTLTLNG 314
L+ L ++NNI +IP +F P L T + N + A+ Q L + T+ L
Sbjct: 181 RGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGL-- 238
Query: 315 ASQITEFPDLTGTANLESLTLTGAQISSLP---QTVCNQLPNLQ---------------V 356
F +G A+L L + Q S Q ++P +
Sbjct: 239 ------FTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSNGI 292
Query: 357 LDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPN 416
+D L +P+ ++ + + +I L N I I F LR ++L+ N+IA I P+
Sbjct: 293 VDCRGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPD 351
Query: 417 AFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473
AF L SL L L N ++ P GL+ L L L N + I + F +L+ + +
Sbjct: 352 AFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKI--NCIRPDAFQDLQNLSL 409
Query: 474 PYAY 477
Y
Sbjct: 410 LSLY 413
Score = 91.7 bits (226), Expect = 3e-18
Identities = 93/364 (25%), Positives = 157/364 (43%), Gaps = 53/364 (14%)
Query: 139 SLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKI 198
++ +RL+ N I +PP FS LR + L +N + EI AF+ L +L ++ L NKI
Sbjct: 310 TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKI 369
Query: 199 HHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSN 258
+P FG L +L +L L+ N+I+ + P A + L N
Sbjct: 370 TDLPRGVFGGLYTLQLLLLNANKINCIR-----------------------PDAFQDLQN 406
Query: 259 LKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPE-LRTLTLNGASQ 317
L L + N I+S+ + F ++ T+H NP F+ + L + LRT + +
Sbjct: 407 LSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNP--FICDCNLKWLADFLRTNPIETSGA 464
Query: 318 ITEFPDLTGTANLESLTLTGAQISS-----LPQTVCNQLPN---------------LQVL 357
P + + + S+ +P T QL + V+
Sbjct: 465 RCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCEANVV 524
Query: 358 DLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIK-VDTFQQLLSLRSLNLAWNKIAIIHPN 416
+ S L +P + Q ++ L +NEI ++ F++L L+ +NL+ NK++ I
Sbjct: 525 ECSSLKLTKIPE-RIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDG 583
Query: 417 AFSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473
AF S+ +L L++N L S GL GL L L N S I +++F L+ + +
Sbjct: 584 AFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRI--SCIHNDSFTGLRNVRL 641
Query: 474 PYAY 477
Y
Sbjct: 642 LSLY 645
Score = 79.3 bits (194), Expect = 1e-14
Identities = 106/422 (25%), Positives = 165/422 (39%), Gaps = 87/422 (20%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP C CE + V+CS L L+++P + T+
Sbjct: 513 CPHKCRCEANV-----VECSSLKLTKIPERIPQSTA------------------------ 543
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
ELRL N ++ + TG++ + L L+ + L N +S +
Sbjct: 544 ELRLNNNEISILEA---TGMF--------------------KKLTHLKKINLSNNKVSEI 580
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
F G S+ L L N L I FR L L+ + L N+I I + +F L ++
Sbjct: 581 EDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVR 640
Query: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
+L L++N+I ++ FD L SL TL+L N + N +L + +R
Sbjct: 641 LLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFN---------CNC-QLAWLGGWLRK-- 688
Query: 274 EKAFVGNPSLITIHFYDN-PIQFVGRSAF------------------QHLPELRTLTLNG 314
K GNP F P+Q V F Q L T+
Sbjct: 689 RKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCS 748
Query: 315 ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
+ P N+ L L G Q + +P + + LQ++DLS N + L SF+
Sbjct: 749 NKHLRALPKGI-PKNVTELYLDGNQFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSFTN 806
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+L + L +N + I FQ L SLR L+L N I+ + F+ + SL L + +N
Sbjct: 807 MSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Query: 433 LL 434
L
Sbjct: 867 PL 868
Score = 74.7 bits (182), Expect = 4e-13
Identities = 84/340 (24%), Positives = 137/340 (40%), Gaps = 37/340 (10%)
Query: 138 RSLQSLRLDANHISYVPPS-CFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALN 196
+S LRL+ N IS + + F L L+ + L +N ++EI AF +++ + L N
Sbjct: 540 QSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTAN 599
Query: 197 KIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRT 255
++ I F L L L L NNRI + F GL ++ L L N + P A T
Sbjct: 600 QLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDT 659
Query: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
L +L L +N + A++G + G Q+ LR + L
Sbjct: 660 LQSLSTLNLLANPFNCNCQLAWLGG-------WLRKRKIVTGNPRCQNPDFLRQIPL--- 709
Query: 316 SQITEFPDLTGTANLES-------------------LTLTGAQISSLPQTVCNQLPNLQV 356
Q FPD E + + + +LP+ + + L +
Sbjct: 710 -QDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYL 768
Query: 357 LDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPN 416
+ L+ S + LQ +DL +N+I + +F + L +L L++N + I P
Sbjct: 769 DGNQFTLVPG--QLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL 826
Query: 417 AFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
AF L SL L L N +S+ + L+HL + N
Sbjct: 827 AFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 68.6 bits (166), Expect = 3e-11
Identities = 49/154 (31%), Positives = 74/154 (48%), Gaps = 11/154 (7%)
Query: 21 GGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQ 80
GG PR CP C C + V CS+ L LP + + L L N +
Sbjct: 726 GGCLPRPQ-----CPQECAC-----LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFT- 774
Query: 81 LLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSL 140
L+P L + ++L+ + L+ N ++ + +FT + L L+L N L+ +P A Q LRSL
Sbjct: 775 LVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSL 834
Query: 141 QSLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
+ L L N IS + F+ + SL HL + N L
Sbjct: 835 RLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 58.9 bits (141), Expect = 2e-08
Identities = 56/199 (28%), Positives = 80/199 (40%), Gaps = 27/199 (13%)
Query: 238 TLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
T+D + L P I N + L + NNI I + F G L + +N I V
Sbjct: 44 TVDCHGTGLQAIPKNIPR--NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVE 101
Query: 298 RSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVL 357
R AF + EL L LN Q+ LP+ + L L
Sbjct: 102 RGAFDDMKELERLRLN-----------------------RNQLHMLPELLFQNNQALSRL 138
Query: 358 DLSYNLLEDLP--SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHP 415
DLS N ++ +P +F L+ + L N+I I+ F+ L L L L N I I
Sbjct: 139 DLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPV 198
Query: 416 NAFSTLPSLIKLDLSSNLL 434
++F+ +P L L SN L
Sbjct: 199 SSFNHMPKLRTFRLHSNHL 217
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/124 (29%), Positives = 62/124 (50%), Gaps = 3/124 (2%)
Query: 76 NNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135
N + LP +P + + EL L GN T +P T Y L+++ L NN++ + +
Sbjct: 749 NKHLRALPKGIP--KNVTELYLDGNQFTLVPGQLSTFKY-LQLVDLSNNKISSLSNSSFT 805
Query: 136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLAL 195
N+ L +L L N + +PP F GL SLR L L N ++ + F +++L + +
Sbjct: 806 NMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGA 865
Query: 196 NKIH 199
N ++
Sbjct: 866 NPLY 869
Score = 48.1 bits (113), Expect = 4e-05
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 4/129 (3%)
Query: 95 LRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP 154
+R + L +PKG + L L NQ VP + L + LQ + L N IS +
Sbjct: 745 VRCSNKHLRALPKGIPKNVTEL---YLDGNQFTLVPGQ-LSTFKYLQLVDLSNNKISSLS 800
Query: 155 PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVV 214
S F+ + L L L NAL IP AF+ L +L+ ++L N I + + F +++SL
Sbjct: 801 NSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSH 860
Query: 215 LHLHNNRIH 223
L + N ++
Sbjct: 861 LAIGANPLY 869
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 135 bits (340), Expect = 2e-31
Identities = 102/357 (28%), Positives = 161/357 (45%), Gaps = 29/357 (8%)
Query: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
GCP C C + V C L +P + + T LDLS N + + P S L
Sbjct: 27 GCPARCECSAQNKS---VSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
Query: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
EE+ L+ N + + GAF L++L+ L L+ N+L+ VP L +L L + N I
Sbjct: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
Query: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
+ F LH+L+ L + DN L I +AF L +L+ +TL + +P A +L SL
Sbjct: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDLNY-NNLDEFPTAIRTLSNLKELGFHSNNIRS 271
+ LHL + I+++ F L L+ L+++Y LD P NL L + N+ +
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLE 331
+P AF L ++ NPI + F L L+
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDL-----------------------IRLQ 300
Query: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEI 386
L + GAQ+ ++ L L+VL++S NLLE L FS + L+ + + +N +
Sbjct: 301 ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 112 bits (280), Expect = 2e-24
Identities = 98/323 (30%), Positives = 157/323 (48%), Gaps = 28/323 (8%)
Query: 117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTE 176
K+L L N+L+ V E + L+ + L N I+ V P F+ L +LR L L N L
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 177 IPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSL 236
+P+ F LS L + ++ NKI + DY F +L +L L + +N + + + F GL SL
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSL 179
Query: 237 ETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFV 296
E L L NL PT LS+L+ SLI++H I +
Sbjct: 180 EQLTLEKCNLTAVPT--EALSHLR---------------------SLISLHLKHLNINNM 216
Query: 297 GRSAFQHLPELRTLTLNGASQITEFP--DLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
AF+ L L+ L ++ + P L G NL SL++T +S++P L L
Sbjct: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLVYL 275
Query: 355 QVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 412
L+LSYN + + + FS +LQ++ + ++ I+ +FQ L LR LN++ N +
Sbjct: 276 THLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLET 335
Query: 413 IHPNAFSTLPSLIKLDLSSNLLS 435
+ N FS+ +L L +++N L+
Sbjct: 336 LEENVFSSPRALEVLSINNNPLA 358
Score = 60.8 bits (146), Expect = 5e-09
Identities = 55/192 (28%), Positives = 78/192 (40%), Gaps = 25/192 (13%)
Query: 260 KELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQIT 319
K L N ++S+ + F+ P L I DN I V AF +L
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNL--------------- 104
Query: 320 EFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQ 377
NL SL L G ++ +P V L NL LD+S N + L F L+
Sbjct: 105 --------FNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
Query: 378 KIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF 437
+++ N++ I F LLSL L L + + A S L SLI L L +++
Sbjct: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
Query: 438 PITGLHGLTHLK 449
P+ L HLK
Sbjct: 217 PVYAFKRLFHLK 228
Score = 54.3 bits (129), Expect = 5e-07
Identities = 41/130 (31%), Positives = 64/130 (49%), Gaps = 7/130 (5%)
Query: 355 QVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 412
++LDLS N L+ + F L++IDL N I ++ F L +LRSL L N++ +
Sbjct: 60 KILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKL 119
Query: 413 IHPNAFSTLPSLIKLDLSSN---LLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELK 469
+ F+ L +L KLD+S N +L + LH L L++ N + IS F L
Sbjct: 120 VPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLV--YISHRAFSGLL 177
Query: 470 VIEMPYAYQC 479
+E +C
Sbjct: 178 SLEQLTLEKC 187
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/152 (32%), Positives = 75/152 (49%), Gaps = 15/152 (9%)
Query: 330 LESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIY 387
LE + L+ I+++ N L NL+ L L N L+ +P F+ L K+D+ N+I
Sbjct: 83 LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIV 142
Query: 388 EIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTH 447
+ FQ L +L+SL + N + I AFS L SL +L L L++ P L+H
Sbjct: 143 ILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVP---TEALSH 199
Query: 448 LKLTGNHALQSLISSENFPELKVIEMP-YAYQ 478
L+ SLIS + L + MP YA++
Sbjct: 200 LR--------SLISL-HLKHLNINNMPVYAFK 222
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/86 (30%), Positives = 44/86 (51%)
Query: 66 VFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125
V+ ++L+LS N IS + L L+EL + G L I +F GL L+VL + N
Sbjct: 273 VYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNL 332
Query: 126 LRHVPTEALQNLRSLQSLRLDANHIS 151
L + + R+L+ L ++ N ++
Sbjct: 333 LETLEENVFSSPRALEVLSINNNPLA 358
Score = 33.1 bits (74), Expect = 1.2
Identities = 17/59 (28%), Positives = 33/59 (55%), Gaps = 3/59 (5%)
Query: 398 LSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSF---PITGLHGLTHLKLTGN 453
+ + L+L+ N++ ++P F + P L ++DLS N++++ L L L+L GN
Sbjct: 57 IETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGN 115
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 134 bits (336), Expect = 5e-31
Identities = 105/362 (29%), Positives = 158/362 (43%), Gaps = 33/362 (9%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTS---YLDLSMNNIS----------- 79
CP C C + V CSD L+ +P ++ +T +++ S +
Sbjct: 22 CPMGCDC-----FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLT 76
Query: 80 ----------QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Q P+ L LE+L + G++ + F+ L SL L L N L +
Sbjct: 77 KVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEAL 136
Query: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
P Q+L +L+SL L N + +P F L L+ L L N L ++P + F L++LQ
Sbjct: 137 PEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQ 196
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
+ L+ N + +P FG L SL L L +N I L + F L LE L L N +
Sbjct: 197 TLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHL 256
Query: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
P +I +L NL L N +R +P F P L+ + N ++ V F HL LR
Sbjct: 257 PLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLR 316
Query: 309 TLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED 366
+L L+ + IT P L L L +++L + L L++L LS N L
Sbjct: 317 SLMLS-YNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTT 375
Query: 367 LP 368
LP
Sbjct: 376 LP 377
Score = 121 bits (303), Expect = 3e-27
Identities = 102/310 (32%), Positives = 146/310 (47%), Gaps = 11/310 (3%)
Query: 38 CHCEPD--GRMLLRVDCSDLGLSELPSNLSVF---TSYLDLSMN-NISQLLPNPL-PSLR 90
C PD G + D G S L + ++F TS L++N N+ + LP L L
Sbjct: 86 CQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLA 145
Query: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
LE L L GN L +P+ F L LK L L N L +P E L SLQ+L+L N +
Sbjct: 146 ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL 205
Query: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLS 210
S +P F L SL+ L+LD N ++E+P Q F L L+ + L N I H+P F +L
Sbjct: 206 SGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLG 265
Query: 211 SLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNI 269
+L L L N + L F L L L +N L+ LSNL+ L N I
Sbjct: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325
Query: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGT 327
+P F L+ ++ N + + + FQ+L +L L+L+ +Q+T P+
Sbjct: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS-KNQLTTLPEGIFDTN 384
Query: 328 ANLESLTLTG 337
NL +L L G
Sbjct: 385 YNLFNLALHG 394
Score = 107 bits (268), Expect = 4e-23
Identities = 87/300 (29%), Positives = 142/300 (47%), Gaps = 28/300 (9%)
Query: 155 PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVV 214
P F GL L L + ++ + F +L++L +TL N + +P+ F +L++L
Sbjct: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
Query: 215 LHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPE 274
LHL N++ +L ++ F L L+TL+L N L + +PE
Sbjct: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQ-----------------------LPE 186
Query: 275 KAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLES 332
+ F SL T+ +N + + + F L L+ L L+ ++ I+E P + LE
Sbjct: 187 ELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLD-SNNISELPPQVFSQLFCLER 245
Query: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIK 390
L L I+ LP ++ L NL L L +N+L LP+ F+ L + L HN++ +
Sbjct: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
Query: 391 VDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
TF L +LRSL L++N I + F L L+KL L SN L++ L+ L+L
Sbjct: 306 EGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLEL 365
Score = 92.0 bits (227), Expect = 2e-18
Identities = 63/174 (36%), Positives = 86/174 (49%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L L NNIS+L P L LE L L NA+T++P F L +L L LQ N LR +P
Sbjct: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP 281
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
+ L L L N + V F+ L +LR L L NA+T +P FR L L
Sbjct: 282 AGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVK 341
Query: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYN 244
+ L N + + F NLS L +L L N++ +L + FD ++L L L+ N
Sbjct: 342 LYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 55.5 bits (132), Expect = 2e-07
Identities = 52/202 (25%), Positives = 80/202 (39%), Gaps = 47/202 (23%)
Query: 260 KELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQIT 319
K + F + ++ +AF NP+L + F + + AF LP L
Sbjct: 52 KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRL------------ 99
Query: 320 EFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKI 379
E L +TG+ +L + + L +L L L++N+LE LP
Sbjct: 100 -----------EDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPE---------- 138
Query: 380 DLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPI 439
FQ L +L SL+L N++ + F L L L+L+ NLL+ P
Sbjct: 139 ------------GLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186
Query: 440 TGLHGLTHLKL--TGNHALQSL 459
H LT L+ N+AL L
Sbjct: 187 ELFHPLTSLQTLKLSNNALSGL 208
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/124 (27%), Positives = 58/124 (46%), Gaps = 5/124 (4%)
Query: 339 QISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLL 398
+++++P + N+ ++ S+ LE +F L K+ + ++ + + D F L
Sbjct: 39 ELATVPLDIPPYTKNIIFVETSFTTLETR-AFGSNPNLTKVVFLNTQLCQFRPDAFGGLP 97
Query: 399 SLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGNHA 455
L L + + + N FS L SL KL L+ N+L + P L L L L GN
Sbjct: 98 RLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQ- 156
Query: 456 LQSL 459
LQ+L
Sbjct: 157 LQAL 160
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 130 bits (326), Expect = 7e-30
Identities = 114/401 (28%), Positives = 170/401 (42%), Gaps = 70/401 (17%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP C C+ +L C++ GL +P S LP+P L +
Sbjct: 27 CPERCDCQHPQHLL----CTNRGLRVVPKTSS----------------LPSPHDVLTY-- 64
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
L GN +T I F L L+ L LQ NQ+R + + + L L+ L L N + +
Sbjct: 65 --SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
P + L LR L+ + N ++ + +F L +L + L N + +PD F L +L+
Sbjct: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182
Query: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
LHL +NRI LGK F L L L+L+ N L T + L+
Sbjct: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLR------------- 229
Query: 274 EKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLE 331
SL ++ N +Q +G FQHLP L L+L G +Q+T G L
Sbjct: 230 --------SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRG-NQLTHLAPEAFWGLEALR 280
Query: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
L L G ++S LP + L +L+ LDLS NE+ +
Sbjct: 281 ELRLEGNRLSQLPTALLEPLHSLEALDLS----------------------GNELSALHP 318
Query: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
TF L LR L+L N ++ + + F+ P+L +LDL N
Sbjct: 319 ATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 74.7 bits (182), Expect = 4e-13
Identities = 73/247 (29%), Positives = 109/247 (44%), Gaps = 11/247 (4%)
Query: 217 LHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEK 275
L N I ++ F L L LDL YN + P LS L+EL +N ++++
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 276 AFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGTANLESL 333
L ++ N I + R +F+ L L L L+G + + PD NL L
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDG-NALGALPDAVFAPLGNLLYL 184
Query: 334 TLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED----LPSFSVCQKLQKIDLRHNEIYEI 389
L +I L + QL L+ L+LS N L+ +F+ + L + L N + +
Sbjct: 185 HLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHL 244
Query: 390 KVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLT 446
FQ L L L+L N++ + P AF L +L +L L N LS P + LH L
Sbjct: 245 GPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLE 304
Query: 447 HLKLTGN 453
L L+GN
Sbjct: 305 ALDLSGN 311
Score = 52.0 bits (123), Expect = 3e-06
Identities = 35/105 (33%), Positives = 49/105 (46%)
Query: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
L L N ++ L P L L ELRL GN L+ +P L+SL+ L L N+L +
Sbjct: 258 LSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALH 317
Query: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALT 175
+L L+ L L N +S + F+ +L L LD N T
Sbjct: 318 PATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWT 362
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 126 bits (317), Expect = 8e-29
Identities = 96/334 (28%), Positives = 155/334 (46%), Gaps = 5/334 (1%)
Query: 33 GCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFL 92
GCP C C R +L C +P + T LDL N I L + S L
Sbjct: 41 GCPPRCECSAQDRAVL---CHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHL 97
Query: 93 EELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISY 152
EEL L N ++ + GAF L++L+ L L++N+L+ +P L +L L + N I
Sbjct: 98 EELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVI 157
Query: 153 VPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSL 212
+ F L++L+ L + DN L I +AF L++L+ +TL + IP A +L L
Sbjct: 158 LLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGL 217
Query: 213 VVLHLHNNRIHSLGKKCFDGLHSLETLDL-NYNNLDEFPTAIRTLSNLKELGFHSNNIRS 271
+VL L + I+++ F L+ L+ L++ ++ LD NL L N+ +
Sbjct: 218 IVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTA 277
Query: 272 IPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL-NGASQITEFPDLTGTANL 330
+P A L ++ NPI + S L L+ + L G + E G L
Sbjct: 278 VPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYL 337
Query: 331 ESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
L ++G Q+++L ++V + + NL+ L L N L
Sbjct: 338 RVLNVSGNQLTTLEESVFHSVGNLETLILDSNPL 371
Score = 112 bits (280), Expect = 2e-24
Identities = 95/334 (28%), Positives = 159/334 (47%), Gaps = 29/334 (8%)
Query: 105 IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSL 164
+P+G T ++L L N+++ + + + L+ L L+ N +S V P F+ L +L
Sbjct: 65 VPEGIPT---ETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNL 121
Query: 165 RHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHS 224
R L L N L IP+ F LS L + ++ NKI + DY F +L +L L + +N +
Sbjct: 122 RTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVY 181
Query: 225 LGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSL 283
+ + F GL+SLE L L NL PT A+ L L L NI +I + +F L
Sbjct: 182 ISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRL 241
Query: 284 ITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSL 343
+ H P L T+T P+ NL SL++T ++++
Sbjct: 242 KVLEI-------------SHWPYLDTMT----------PNCLYGLNLTSLSITHCNLTAV 278
Query: 344 PQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQ--KLQKIDLRHNEIYEIKVDTFQQLLSLR 401
P L L+ L+LSYN + + + + +LQ+I L ++ ++ F+ L LR
Sbjct: 279 PYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLR 338
Query: 402 SLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLS 435
LN++ N++ + + F ++ +L L L SN L+
Sbjct: 339 VLNVSGNQLTTLEESVFHSVGNLETLILDSNPLA 372
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/176 (32%), Positives = 85/176 (48%), Gaps = 17/176 (9%)
Query: 308 RTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
R TLN + FP +LE L L +S++ N L NL+ L L N L+ +
Sbjct: 82 RIKTLN-QDEFASFP------HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLI 134
Query: 368 PS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
P F+ L K+D+ N+I + FQ L +L+SL + N + I AFS L SL
Sbjct: 135 PLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLE 194
Query: 426 KLDLSSNLLSSFP---ITGLHGLTHLKLTGNHALQSLISSENFP---ELKVIEMPY 475
+L L L+S P ++ LHGL L+L H + I +F LKV+E+ +
Sbjct: 195 QLTLEKCNLTSIPTEALSHLHGLIVLRL--RHLNINAIRDYSFKRLYRLKVLEISH 248
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/86 (33%), Positives = 49/86 (56%)
Query: 66 VFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQ 125
V+ +L+LS N IS + + L L L+E++L G L + AF GL L+VL + NQ
Sbjct: 287 VYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQ 346
Query: 126 LRHVPTEALQNLRSLQSLRLDANHIS 151
L + ++ +L++L LD+N ++
Sbjct: 347 LTTLEESVFHSVGNLETLILDSNPLA 372
Score = 43.1 bits (100), Expect = 0.001
Identities = 28/78 (35%), Positives = 38/78 (48%), Gaps = 3/78 (3%)
Query: 379 IDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP 438
+DL N I + D F L L L N ++ + P AF+ L +L L L SN L P
Sbjct: 76 LDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIP 135
Query: 439 I---TGLHGLTHLKLTGN 453
+ TGL LT L ++ N
Sbjct: 136 LGVFTGLSNLTKLDISEN 153
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 126 bits (317), Expect = 8e-29
Identities = 120/437 (27%), Positives = 195/437 (44%), Gaps = 41/437 (9%)
Query: 7 GVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSV 66
GV ++ L LA +S SG CPT C C VDC LGL +P +
Sbjct: 7 GVGAAVRARLALALALASVLSGPPAVACPTKCTCSAAS-----VDCHGLGLRAVPRGIPR 61
Query: 67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
LDL NNI+++ L+ L L L N ++ I +GAF L L+ L L N+L
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Query: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
+ +P Q+ L L L N I +P F G+ +++L LD+N ++ I AFR+L
Sbjct: 122 QVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALR 181
Query: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIH----------------SLGK--K 228
L+ +TL N I I +F ++ + L LH+N ++ ++G+
Sbjct: 182 DLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTL 241
Query: 229 CFDGLH--SLETLDLNYNNL------DEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGN 280
C +H D+ E P+ + SNNI K +
Sbjct: 242 CMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEI 301
Query: 281 PS-----LITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEF-PD-LTGTANLESL 333
P+ ++ I N I+ + AF +L+ + ++ +QI++ PD G +L SL
Sbjct: 302 PANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS-KNQISDIAPDAFQGLKSLTSL 360
Query: 334 TLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL--PSFSVCQKLQKIDLRHNEIYEIKV 391
L G +I+ + + + + L +LQ+L L+ N + L +F Q L + L N++ I
Sbjct: 361 VLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISK 420
Query: 392 DTFQQLLSLRSLNLAWN 408
F L S+++L+LA N
Sbjct: 421 GLFAPLQSIQTLHLAQN 437
Score = 107 bits (268), Expect = 4e-23
Identities = 121/438 (27%), Positives = 182/438 (41%), Gaps = 93/438 (21%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP+ C C + VDC GL E+P+NL +
Sbjct: 280 CPSPCTCSNN-----IVDCRGKGLMEIPANLP------------------------EGIV 310
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
E+RL N++ IP GAFT LK + + NQ+ + +A Q L+SL SL L N I+ +
Sbjct: 311 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEI 370
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
F GL SL+ L L+ N + + V F+ L L ++L NK+ I F L S+
Sbjct: 371 AKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQ 430
Query: 214 VLHLHNNRI----HSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFH---S 266
LHL N H + + +ET ++ A + +S +K F S
Sbjct: 431 TLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRL--ANKRISQIKSKKFRCSGS 488
Query: 267 NNIRS-----------IPEKAFV-------GNPSLITIHFY-----------DNPIQFVG 297
+ RS PEK N L+ I + DN + +
Sbjct: 489 EDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLE 548
Query: 298 RSA-FQHLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
+ F+ LP LR + L+ ++I E + G A+++ L LTG Q+ ++ V L L
Sbjct: 549 ATGIFKKLPNLRKINLSN-NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGL 607
Query: 355 QVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIH 414
+ L L NL+ + + DTF L S+R L+L N+I I
Sbjct: 608 KTLMLRSNLIGCVSN----------------------DTFAGLSSVRLLSLYDNRITTIT 645
Query: 415 PNAFSTLPSLIKLDLSSN 432
P AF+TL SL ++L SN
Sbjct: 646 PGAFTTLVSLSTINLLSN 663
Score = 96.7 bits (239), Expect = 9e-20
Identities = 105/384 (27%), Positives = 169/384 (44%), Gaps = 36/384 (9%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL----LPNPLPSL 89
CP C CE G + VDCS+ L +PS+L + + L L+ N +S L + LP+L
Sbjct: 505 CPEKCRCE--GTI---VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNL 559
Query: 90 RFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANH 149
R ++ L+ N + + +GAF G S++ LML NQL V + L L++L L +N
Sbjct: 560 R---KINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNL 616
Query: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
I V F+GL S+R L L DN +T I AF +L +L + L N + A+
Sbjct: 617 IGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAW--- 673
Query: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNI 269
+ L RI S +C L E P + + G ++
Sbjct: 674 ---LGKWLRKRRIVSGNPRCQKPFF-----------LKEIPIQDVAIQDFTCDGNEESSC 719
Query: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFP-DLTGTA 328
+ P + + ++ + R + + E L L G + +T P +L+
Sbjct: 720 QLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE---LYLEG-NHLTAVPRELSALR 775
Query: 329 NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSVCQKLQKIDLRHNEI 386
+L + L+ IS L + + +L L LSYN L +P +F+ + L+ + L N+I
Sbjct: 776 HLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 835
Query: 387 YEIKVDTFQQLLSLRSLNLAWNKI 410
+ +F L SL L L N +
Sbjct: 836 SSVPEGSFNDLTSLSHLALGTNPL 859
Score = 84.3 bits (207), Expect = 5e-16
Identities = 81/329 (24%), Positives = 143/329 (43%), Gaps = 28/329 (8%)
Query: 143 LRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIP 202
+RL+ N I +P F+ L+ + + N +++I AF+ L +L ++ L NKI I
Sbjct: 312 IRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIA 371
Query: 203 DYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKEL 262
F L SL +L L+ N+I+ L F L +L L L N L +T+S
Sbjct: 372 KGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL-------QTISKGLFA 424
Query: 263 GFHSNNIRSIPEKAFVGNPSL--ITIHFYDNPIQFVG-------RSAFQHLPELRT--LT 311
S + + FV + L + + DNPI+ G R A + + ++++
Sbjct: 425 PLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFR 484
Query: 312 LNGASQITE------FPDLTGTANLES----LTLTGAQISSLPQTVCNQLPNLQVLDLSY 361
+G+ F DL + + ++ +P + + +L++ D
Sbjct: 485 CSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEV 544
Query: 362 NLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTL 421
++LE F L+KI+L +N+I E++ F S++ L L N++ +H F L
Sbjct: 545 SVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGL 604
Query: 422 PSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
L L L SNL+ GL+ ++L
Sbjct: 605 SGLKTLMLRSNLIGCVSNDTFAGLSSVRL 633
Score = 79.0 bits (193), Expect = 2e-14
Identities = 54/153 (35%), Positives = 76/153 (49%), Gaps = 6/153 (3%)
Query: 22 GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL 81
G+ S L CP C C M V CS+ GL LP + + L L N+++ +
Sbjct: 713 GNEESSCQLSPRCPEQCTC-----METVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAV 767
Query: 82 LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
P L +LR L + L+ N+++ + F+ + L L+L N+LR +P A LRSL+
Sbjct: 768 -PRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLR 826
Query: 142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNAL 174
L L N IS VP F+ L SL HL L N L
Sbjct: 827 VLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 63.5 bits (153), Expect = 8e-10
Identities = 47/158 (29%), Positives = 76/158 (48%), Gaps = 7/158 (4%)
Query: 258 NLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQ 317
N + L NNI I + F G +L +H DN + + R AFQ L +L L LN ++
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLN-KNK 120
Query: 318 ITEFPDL--TGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYN---LLEDLPSFSV 372
+ P+L T L L L+ QI +P+ + +++ L L N +ED +F
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIED-GAFRA 179
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKI 410
+ L+ + L +N I I V +F + +R+L L N +
Sbjct: 180 LRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/155 (32%), Positives = 78/155 (50%), Gaps = 11/155 (7%)
Query: 118 VLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDD---NAL 174
V+ N LR +P +++ L L+ NH++ VP L +LRHL L D N++
Sbjct: 735 VVRCSNKGLRALPRGMPKDVTELY---LEGNHLTAVPRE----LSALRHLTLIDLSNNSI 787
Query: 175 TEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLH 234
+ + F ++S L + L+ N++ IP +AF L SL VL LH N I S+ + F+ L
Sbjct: 788 SMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLT 847
Query: 235 SLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNI 269
SL L L N L ++R LS + G+ I
Sbjct: 848 SLSHLALGTNPL-HCDCSLRWLSEWVKAGYKEPGI 881
Score = 61.2 bits (147), Expect = 4e-09
Identities = 46/129 (35%), Positives = 64/129 (49%), Gaps = 4/129 (3%)
Query: 95 LRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVP 154
+R + L +P+G + L L+ N L VP E L LR L + L N IS +
Sbjct: 736 VRCSNKGLRALPRGMPKDVTEL---YLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLT 791
Query: 155 PSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVV 214
FS + L L L N L IPV AF L +L+ +TL N I +P+ +F +L+SL
Sbjct: 792 NYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSH 851
Query: 215 LHLHNNRIH 223
L L N +H
Sbjct: 852 LALGTNPLH 860
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/150 (31%), Positives = 72/150 (48%), Gaps = 6/150 (4%)
Query: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS 369
L N ++IT+ D G NL L L Q+S + + L L+ L L+ N L+ LP
Sbjct: 68 LDRNNITRITKM-DFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPE 126
Query: 370 --FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKL 427
F KL ++DL N+I I F+ + +++L L N I+ I AF L L L
Sbjct: 127 LLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEIL 186
Query: 428 DLSSNLLSSFPITGLHGLTH---LKLTGNH 454
L++N +S +T + + L+L NH
Sbjct: 187 TLNNNNISRILVTSFNHMPKIRTLRLHSNH 216
Score = 53.5 bits (127), Expect = 9e-07
Identities = 42/152 (27%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVCQKLQKIDLRHN 384
T + S+ G + ++P+ + N + LDL N + + F+ + L+ + L N
Sbjct: 39 TCSAASVDCHGLGLRAVPRGIPR---NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDN 95
Query: 385 EIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHG 444
++ I+ FQ L L L L NK+ ++ F + P L +LDLS N + P G
Sbjct: 96 QVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRG 155
Query: 445 LT---HLKLTGNHALQSLISSENFPELKVIEM 473
+T +L+L NH S I F L+ +E+
Sbjct: 156 ITDVKNLQLDNNHI--SCIEDGAFRALRDLEI 185
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 125 bits (315), Expect = 1e-28
Identities = 123/434 (28%), Positives = 179/434 (41%), Gaps = 62/434 (14%)
Query: 32 RGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRF 91
+ CP C C VDC L L +P N+ T LDL+ NNI
Sbjct: 26 QACPAQCSCSGS-----TVDCHGLALRSVPRNIPRNTERLDLNGNNI------------- 67
Query: 92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHIS 151
T I K F GL L+VL L N++ + A Q+L+ L+ LRL+ NH+
Sbjct: 68 -----------TRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQ 116
Query: 152 YVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSS 211
P F G L L L +N + IP +AFR ++ + L N+I I D AF L
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176
Query: 212 LVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNN-------------LDEFPTAIRTLSN 258
L VL L+NN I L F+ + L T L+ NN L + P
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQC 236
Query: 259 LKELGFHSNNIRSIPEKAFVGN-------PSLITIH------FYDNPIQFVGRSAFQ--- 302
+ +N+ + ++ FV + PS +H +N + G+ +
Sbjct: 237 MGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT 296
Query: 303 HLPELRTLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLS 360
+LPE T + I P + L + L+ QIS L L +L L L
Sbjct: 297 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLY 356
Query: 361 YNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAF 418
N + +LP F LQ + L N+I ++VD FQ L +L L+L NK+ I F
Sbjct: 357 GNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTF 416
Query: 419 STLPSLIKLDLSSN 432
S L ++ + L+ N
Sbjct: 417 SPLRAIQTMHLAQN 430
Score = 110 bits (274), Expect = 8e-24
Identities = 115/415 (27%), Positives = 176/415 (42%), Gaps = 39/415 (9%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP C C + VDC GL+E+P+NL + + L N I + P + L
Sbjct: 273 CPAACTCSNN-----IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLR 327
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
+ L+ N ++ + AF GL SL L+L N++ +P + L SLQ L L+AN I+ +
Sbjct: 328 RIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCL 387
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
F LH+L L L DN L I F L A+Q M LA N I D L+
Sbjct: 388 RVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPF--ICDCHLKWLAD-- 443
Query: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIR-------TLSNLKELGFHS 266
+LH N I + G +C L + +F + + T +L
Sbjct: 444 --YLHTNPIETSGARC-TSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDC 500
Query: 267 NNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT-LTLNGASQITEFPDLT 325
+ PEK ++ + N I +H+P+ L LN EF L
Sbjct: 501 FADLACPEKCRCEGTTVDCSNQKLNKIP-------EHIPQYTAELRLNN----NEFTVLE 549
Query: 326 GTA------NLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL--PSFSVCQKLQ 377
T L + + +I+ + + + + L+ N LE++ F + L+
Sbjct: 550 ATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLK 609
Query: 378 KIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+ LR N I + D+F L S+R L+L N+I + P AF TL SL L+L +N
Sbjct: 610 TLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLAN 664
Score = 89.4 bits (220), Expect = 1e-17
Identities = 87/357 (24%), Positives = 153/357 (42%), Gaps = 51/357 (14%)
Query: 131 TEALQNL-RSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
TE NL ++ +RL+ N I +PP FS LR + L +N ++E+ AF+ L +L
Sbjct: 292 TEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLN 351
Query: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
++ L NKI +P F L SL +L L+ N+I+ L F LH+L L L N L
Sbjct: 352 SLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTI 411
Query: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIH-------FYDNPIQFVG----- 297
A T S L R+I NP + H + NPI+ G
Sbjct: 412 --AKGTFSPL----------RAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTS 459
Query: 298 --RSAFQHLPELRTLTLNGASQITEFPDLTGTANLES----------------------L 333
R A + + ++++ +++ F + GT + S +
Sbjct: 460 PRRLANKRIGQIKSKKFRCSAKEQYF--IPGTEDYRSKLSGDCFADLACPEKCRCEGTTV 517
Query: 334 TLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDT 393
+ +++ +P+ + L++ + + +LE F +L+KI+ +N+I +I+
Sbjct: 518 DCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGA 577
Query: 394 FQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKL 450
F+ + + L N++ + F L SL L L SN ++ GL+ ++L
Sbjct: 578 FEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRL 634
Score = 85.1 bits (209), Expect = 3e-16
Identities = 106/422 (25%), Positives = 169/422 (40%), Gaps = 87/422 (20%)
Query: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLE 93
CP C CE VDCS+ L+++P ++ +T+
Sbjct: 506 CPEKCRCEGT-----TVDCSNQKLNKIPEHIPQYTA------------------------ 536
Query: 94 ELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYV 153
ELRL N T + TG++ + L L+ + N I+ +
Sbjct: 537 ELRLNNNEFTVLEA---TGIF--------------------KKLPQLRKINFSNNKITDI 573
Query: 154 PPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLV 213
F G + + L N L + + F+ L +L+ + L N+I + + +F LSS+
Sbjct: 574 EEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVR 633
Query: 214 VLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIP 273
+L L++N+I ++ FD LHSL TL+L N + L LG R +
Sbjct: 634 LLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFN-------CNCYLAWLGEWLRKKRIV- 685
Query: 274 EKAFVGNPSLITIHFYDN-PIQFVGRSAF--------------QHLPE----LRTLTLNG 314
GNP +F PIQ V F P L T+
Sbjct: 686 ----TGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCS 741
Query: 315 ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLP--SFSV 372
+ P ++ L L G Q + +P+ + N +L ++DLS N + L SFS
Sbjct: 742 NKGLKVLPKGI-PRDVTELYLDGNQFTLVPKELSNY-KHLTLIDLSNNRISTLSNQSFSN 799
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
+L + L +N + I TF L SLR L+L N I+++ AF+ L +L L + +N
Sbjct: 800 MTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGAN 859
Query: 433 LL 434
L
Sbjct: 860 PL 861
Score = 70.9 bits (172), Expect = 5e-12
Identities = 52/178 (29%), Positives = 77/178 (43%), Gaps = 30/178 (16%)
Query: 22 GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQL 81
G+ S L CPT C C + V CS+ GL LP +
Sbjct: 715 GNDDNSCSPLSRCPTECTC-----LDTVVRCSNKGLKVLPKGIP---------------- 753
Query: 82 LPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQ 141
R + EL L GN T +PK + L ++ L NN++ + ++ N+ L
Sbjct: 754 --------RDVTELYLDGNQFTLVPK-ELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLL 804
Query: 142 SLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIH 199
+L L N + +PP F GL SLR L L N ++ +P AF LSAL + + N ++
Sbjct: 805 TLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLY 862
Score = 57.8 bits (138), Expect = 5e-08
Identities = 79/303 (26%), Positives = 133/303 (43%), Gaps = 22/303 (7%)
Query: 167 LWLDDNALTEIPVQA-FRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSL 225
L L++N T + F+ L L+ + + NKI I + AF S + + L +NR+ ++
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENV 597
Query: 226 GKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLI 284
K F GL SL+TL L N + + LS+++ L + N I ++ AF SL
Sbjct: 598 QHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLS 657
Query: 285 TIHFYDNPIQFVGRSAF--QHLPELRTLTLNGASQ----ITEFP-------DLTGTANLE 331
T++ NP A+ + L + R +T N Q + E P D T +
Sbjct: 658 TLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGND 717
Query: 332 SLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKV 391
+ + +S P T C L V+ S L+ LP + + + ++ L N+ + +
Sbjct: 718 DNSCS--PLSRCP-TECTCLDT--VVRCSNKGLKVLPK-GIPRDVTELYLDGNQ-FTLVP 770
Query: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLT 451
L ++L+ N+I+ + +FS + L+ L LS N L P GL L+L
Sbjct: 771 KELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLL 830
Query: 452 GNH 454
H
Sbjct: 831 SLH 833
Score = 55.5 bits (132), Expect = 2e-07
Identities = 46/163 (28%), Positives = 80/163 (49%), Gaps = 6/163 (3%)
Query: 298 RSAFQHLPE-LRTLTLNG--ASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNL 354
RS +++P L LNG ++IT+ D G +L L L +IS++ + L L
Sbjct: 47 RSVPRNIPRNTERLDLNGNNITRITK-TDFAGLRHLRVLQLMENKISTIERGAFQDLKEL 105
Query: 355 QVLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAI 412
+ L L+ N L+ P F KL ++DL N+I I F+ + +++L L +N+I+
Sbjct: 106 ERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISC 165
Query: 413 IHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHA 455
I AF L L L L++N ++ + + + L+ H+
Sbjct: 166 IEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHS 208
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (311), Expect = 4e-28
Identities = 114/390 (29%), Positives = 168/390 (43%), Gaps = 59/390 (15%)
Query: 9 LLSLPVLLQLATGGSSPRSGVLLR-GCPTHCHCE--------PDGRMLLRVDCSDLGLSE 59
LL P+LL G ++ V CP C C+ R VDC+DL L+
Sbjct: 3 LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
Query: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119
+P L T L L N+I ++ + L L L EL L+ N+ + F L L L
Sbjct: 63 VPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSL 122
Query: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179
L+ NQL + + L SLQ L L+ N + + P FSGL +L L L+ N L I
Sbjct: 123 HLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDS 182
Query: 180 Q------------------------AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVL 215
+ FR L+ L+++ LA + I DYA L SL L
Sbjct: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESL 242
Query: 216 HLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHS-NNIRSIP 273
++N++ + ++ + + L+ LDLN N L P + +LKELG ++ + SI
Sbjct: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
Query: 274 EKAFVGNPSLITIHFYDNP-IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332
+ A V P L + +NP + F+ AF HLP++ TL LN +
Sbjct: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNA---------------- 346
Query: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYN 362
+S+L Q LPNLQ + L N
Sbjct: 347 -------LSALHQQTVESLPNLQEVGLHGN 369
Score = 115 bits (287), Expect = 2e-25
Identities = 96/312 (30%), Positives = 151/312 (48%), Gaps = 11/312 (3%)
Query: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
++ VPP+ +G +L L N++ + L+ L + L+ N D F L
Sbjct: 60 LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
Query: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNN 268
L+ LHL N++ L F GL SL+ L LN+N L P A LSNL L +SN
Sbjct: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
Query: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTG 326
+R+I + F P+L + N + + F+ L LR+L L G + + E D L G
Sbjct: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN-LREISDYALEG 235
Query: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386
+LESL+ Q++ +P+ Q+P L+ LDL+ N L+ + L +L N +
Sbjct: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
Query: 387 YE-IKVDTFQ--QLLSLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGL 442
E + +D F L L L++ N +++ IHP AF LP + L L++N LS+ +
Sbjct: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
Query: 443 HGLTHLKLTGNH 454
L +L+ G H
Sbjct: 356 ESLPNLQEVGLH 367
Score = 76.6 bits (187), Expect = 9e-14
Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 10/194 (5%)
Query: 80 QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRS 139
++LPN LE L + GN + I F L +L+ L+L LR + AL+ L+S
Sbjct: 186 EMLPN-------LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
Query: 140 LQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLA-LNKI 198
L+SL N ++ VP + L+ L L+ N L + F ++ L+ + L + ++
Sbjct: 239 LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEEL 298
Query: 199 HHIPDYAFGNLSSLVVLHLHNN-RIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256
I +A NL L L + NN R+ + + F L +ETL LN N L + +L
Sbjct: 299 VSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL 358
Query: 257 SNLKELGFHSNNIR 270
NL+E+G H N IR
Sbjct: 359 PNLQEVGLHGNPIR 372
Score = 68.2 bits (165), Expect = 3e-11
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 3/221 (1%)
Query: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
L+NL EL N+ + F P L+++H +N + + +F L L+ L LN
Sbjct: 92 LANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHN 151
Query: 316 SQITEFPD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL--PSFSV 372
P +G +NL L L + ++ LPNL++L + N ++ + +F
Sbjct: 152 QLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRP 211
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
L+ + L + EI + L SL SL+ N++A + A +P L LDL+ N
Sbjct: 212 LANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKN 271
Query: 433 LLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473
L + HLK G + ++ L+S + F + + E+
Sbjct: 272 PLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPEL 312
Score = 35.8 bits (81), Expect = 0.19
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 4/94 (4%)
Query: 61 PSNLSVFTSYLDLSMNNISQLLPNP---LPSLRFLEELRLAGNA-LTYIPKGAFTGLYSL 116
P + + +L +NN+ +L+ L +L L +L + N L++I AF L +
Sbjct: 278 PGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQM 337
Query: 117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
+ LML NN L + + +++L +LQ + L N I
Sbjct: 338 ETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 124 bits (311), Expect = 4e-28
Identities = 114/390 (29%), Positives = 168/390 (43%), Gaps = 59/390 (15%)
Query: 9 LLSLPVLLQLATGGSSPRSGVLLR-GCPTHCHCE--------PDGRMLLRVDCSDLGLSE 59
LL P+LL G ++ V CP C C+ R VDC+DL L+
Sbjct: 3 LLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTA 62
Query: 60 LPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVL 119
+P L T L L N+I ++ + L L L EL L+ N+ + F L L L
Sbjct: 63 VPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSL 122
Query: 120 MLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPV 179
L+ NQL + + L SLQ L L+ N + + P FSGL +L L L+ N L I
Sbjct: 123 HLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDS 182
Query: 180 Q------------------------AFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVL 215
+ FR L+ L+++ LA + I DYA L SL L
Sbjct: 183 RWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESL 242
Query: 216 HLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHS-NNIRSIP 273
++N++ + ++ + + L+ LDLN N L P + +LKELG ++ + SI
Sbjct: 243 SFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSID 302
Query: 274 EKAFVGNPSLITIHFYDNP-IQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLES 332
+ A V P L + +NP + F+ AF HLP++ TL LN +
Sbjct: 303 KFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNA---------------- 346
Query: 333 LTLTGAQISSLPQTVCNQLPNLQVLDLSYN 362
+S+L Q LPNLQ + L N
Sbjct: 347 -------LSALHQQTVESLPNLQEVGLHGN 369
Score = 115 bits (287), Expect = 2e-25
Identities = 96/312 (30%), Positives = 151/312 (48%), Gaps = 11/312 (3%)
Query: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
++ VPP+ +G +L L N++ + L+ L + L+ N D F L
Sbjct: 60 LTAVPPALPAGTQTLL---LQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
Query: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTLSNLKELGFHSNN 268
L+ LHL N++ L F GL SL+ L LN+N L P A LSNL L +SN
Sbjct: 117 PQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNL 176
Query: 269 IRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTG 326
+R+I + F P+L + N + + F+ L LR+L L G + + E D L G
Sbjct: 177 LRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMN-LREISDYALEG 235
Query: 327 TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEI 386
+LESL+ Q++ +P+ Q+P L+ LDL+ N L+ + L +L N +
Sbjct: 236 LQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNM 295
Query: 387 YE-IKVDTFQ--QLLSLRSLNLAWN-KIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGL 442
E + +D F L L L++ N +++ IHP AF LP + L L++N LS+ +
Sbjct: 296 EELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTV 355
Query: 443 HGLTHLKLTGNH 454
L +L+ G H
Sbjct: 356 ESLPNLQEVGLH 367
Score = 76.6 bits (187), Expect = 9e-14
Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 10/194 (5%)
Query: 80 QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRS 139
++LPN LE L + GN + I F L +L+ L+L LR + AL+ L+S
Sbjct: 186 EMLPN-------LEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQS 238
Query: 140 LQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLA-LNKI 198
L+SL N ++ VP + L+ L L+ N L + F ++ L+ + L + ++
Sbjct: 239 LESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEEL 298
Query: 199 HHIPDYAFGNLSSLVVLHLHNN-RIHSLGKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256
I +A NL L L + NN R+ + + F L +ETL LN N L + +L
Sbjct: 299 VSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESL 358
Query: 257 SNLKELGFHSNNIR 270
NL+E+G H N IR
Sbjct: 359 PNLQEVGLHGNPIR 372
Score = 68.2 bits (165), Expect = 3e-11
Identities = 57/221 (25%), Positives = 99/221 (44%), Gaps = 3/221 (1%)
Query: 256 LSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGA 315
L+NL EL N+ + F P L+++H +N + + +F L L+ L LN
Sbjct: 92 LANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHN 151
Query: 316 SQITEFPD-LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL--PSFSV 372
P +G +NL L L + ++ LPNL++L + N ++ + +F
Sbjct: 152 QLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRP 211
Query: 373 CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN 432
L+ + L + EI + L SL SL+ N++A + A +P L LDL+ N
Sbjct: 212 LANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKN 271
Query: 433 LLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEM 473
L + HLK G + ++ L+S + F + + E+
Sbjct: 272 PLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPEL 312
Score = 35.8 bits (81), Expect = 0.19
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 4/94 (4%)
Query: 61 PSNLSVFTSYLDLSMNNISQLLPNP---LPSLRFLEELRLAGNA-LTYIPKGAFTGLYSL 116
P + + +L +NN+ +L+ L +L L +L + N L++I AF L +
Sbjct: 278 PGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQM 337
Query: 117 KVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
+ LML NN L + + +++L +LQ + L N I
Sbjct: 338 ETLMLNNNALSALHQQTVESLPNLQEVGLHGNPI 371
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,723,168
Number of Sequences: 37866
Number of extensions: 1505525
Number of successful extensions: 9050
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 4372
Number of HSP's gapped (non-prelim): 1784
length of query: 907
length of database: 18,247,518
effective HSP length: 111
effective length of query: 796
effective length of database: 14,044,392
effective search space: 11179336032
effective search space used: 11179336032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.