Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4504151
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504151 granulin precursor [Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504151 granulin precursor [Homo sapiens] 1355 0.0
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 91 4e-18
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 79 9e-15
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 75 2e-13
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 73 6e-13
gi|55770876 notch4 preproprotein [Homo sapiens] 66 1e-10
gi|38490568 keratin associated protein 10-4 [Homo sapiens] 64 3e-10
gi|93102379 low density lipoprotein-related protein 1B precursor... 64 4e-10
gi|56237021 fibrillin 3 precursor [Homo sapiens] 63 7e-10
gi|134031945 SCO-spondin [Homo sapiens] 62 1e-09
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 62 2e-09
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 61 3e-09
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 61 3e-09
gi|148727298 keratin associated protein 10-6 [Homo sapiens] 60 4e-09
gi|110347437 latent transforming growth factor beta binding prot... 59 2e-08
gi|110347412 latent transforming growth factor beta binding prot... 59 2e-08
gi|110347431 latent transforming growth factor beta binding prot... 59 2e-08
gi|134244285 Notch homolog 3 [Homo sapiens] 58 2e-08
gi|38490571 keratin associated protein 10-7 [Homo sapiens] 58 3e-08
gi|66346695 fibrillin 2 precursor [Homo sapiens] 57 4e-08
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 57 4e-08
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 57 6e-08
gi|24430141 fibrillin 1 precursor [Homo sapiens] 55 2e-07
gi|63053512 keratin associated protein 10-1 [Homo sapiens] 55 2e-07
gi|61744471 low density lipoprotein receptor-related protein 8 i... 54 3e-07
gi|65301119 low density lipoprotein receptor-related protein 8 i... 54 3e-07
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 54 3e-07
gi|154759249 keratin associated protein 10-11 [Homo sapiens] 54 4e-07
gi|46249414 latent transforming growth factor beta binding prote... 53 9e-07
gi|46249412 latent transforming growth factor beta binding prote... 53 9e-07
>gi|4504151 granulin precursor [Homo sapiens]
Length = 593
Score = 1355 bits (3508), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGP 60
MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGP
Sbjct: 1 MWTLVSWVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGP 60
Query: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNS 120
CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNS
Sbjct: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNS 120
Query: 121 VGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCIT 180
VGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCIT
Sbjct: 121 VGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCIT 180
Query: 181 PTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC 240
PTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC
Sbjct: 181 PTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC 240
Query: 241 SDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ 300
SDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ
Sbjct: 241 SDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ 300
Query: 301 SGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQAL 360
SGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQAL
Sbjct: 301 SGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQAL 360
Query: 361 KRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS 420
KRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS
Sbjct: 361 KRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS 420
Query: 421 EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQH 480
EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQH
Sbjct: 421 EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQH 480
Query: 481 CCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQG 540
CCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQG
Sbjct: 481 CCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQG 540
Query: 541 WACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL 593
WACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL
Sbjct: 541 WACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL 593
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 90.5 bits (223), Expect = 4e-18
Identities = 155/647 (23%), Positives = 201/647 (31%), Gaps = 163/647 (25%)
Query: 18 TRCP---DGQFCPVA--CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHS 72
TRC DG P C PG +SC R + H G C +CSAGH
Sbjct: 828 TRCSCANDGHCHPATGHCSCAPGWTGFSCQR-------ACDTGHWGPDCSHPCNCSAGHG 880
Query: 73 CIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFE 132
+SG C C CP+G G C QR QC
Sbjct: 881 SCDAISGLCLCEAGYVGPRC---EQQCPQGHF----GPGCEQR--------CQC------ 919
Query: 133 CPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAF---------------CDLVHTR 177
C V G+ C + + CE H CP G F CD V+
Sbjct: 920 --QHGAACDHVSGACTCPAGWRGTFCE---HACPAGFFGLDCRSACNCTAGAACDAVNGS 974
Query: 178 CITPTGTH--PLAKKLPA----QRTNRAVALSSSVMCPDARSRCP-----DGSTCCE-LP 225
C+ P G A+ PA ++A A + C +C G +C + P
Sbjct: 975 CLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGPSCLQACP 1034
Query: 226 SGKYG--------------CCPMPNATCCSD-------HLHCCPQDT------------- 251
+G YG C P+ C + C P+D
Sbjct: 1035 AGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNG 1094
Query: 252 -VCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC------CRLQSGAW 304
+CD +CL T D C SCP G C CR G
Sbjct: 1095 GLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFT 1154
Query: 305 G------CCPFTQAVCCEDHIHCCPAGFTCDTQKGTCE--QGPHQVPWMEKAPAHLSLPD 356
G C P + C C C GTC G H ++ P P
Sbjct: 1155 GSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPG 1214
Query: 357 PQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGY---TCVAE 413
C+ + C + +C T G C P +D CPQG C
Sbjct: 1215 ---------CEQLCGCLNGGSCDAAT----GACRCPTGFLGTDCNLTCPQGRFGPNCTHV 1261
Query: 414 GQCQRGS--EIVAGLEKMPARRASLSHPR-------DIGCDQHTSCPVGQTCCPSLGGSW 464
C +G+ + V G P RA + R +GC+ SC G C S GS
Sbjct: 1262 CGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHAS-NGSC 1320
Query: 465 ACCQLPHAVCCEDRQHCCPA---GYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVEC 521
+C CE CP G C+++ SC + +PAT R C
Sbjct: 1321 SCGLGWTGRHCE---LACPPGRYGAACHLEC-SCHNN-STCEPATGTCR----------C 1365
Query: 522 GEGHFCHDNQTCCRDNRQGWAC---CPYRQGVCC--ADRRHCCPAGF 563
G G + + C G C C + G C R CPAGF
Sbjct: 1366 GPGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGF 1412
Score = 67.8 bits (164), Expect = 3e-11
Identities = 125/497 (25%), Positives = 154/497 (30%), Gaps = 109/497 (21%)
Query: 20 CPDGQFC-PVA--CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHS-CIF 75
C +G C PV+ C G A +C + L + RH GG C C C+
Sbjct: 1048 CQNGGTCDPVSGHCACPEGWAGLACEKECLPRDVRAGCRHSGG-CLNGGLCDPHTGRCLC 1106
Query: 76 TVSGTSSCCPFPEAVACGDGHHC-----CPRGFHCSADGRSCFQRSGNNSVGAIQ-CPDS 129
T C P + G C CP G C +C G G Q CP
Sbjct: 1107 PAGWTGDKCQSP-CLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPG 1165
Query: 130 QF--------ECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITP 181
F +CP + C G+ C C+ R CP G + C
Sbjct: 1166 SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQR---CPPGRYGPGCEQLCGCL 1222
Query: 182 TGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDG--STCCEL--PSGKYGCCPMPNA 237
G S RCP G T C L P G++G PN
Sbjct: 1223 NG--------------------GSCDAATGACRCPTGFLGTDCNLTCPQGRFG----PNC 1258
Query: 238 TCCSDHLHCCPQDTVCDLIQSKCLSKEN-ATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC 296
T H+ C Q CD + CL A P + G V C+ SC +G C
Sbjct: 1259 T----HVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFG-VGCEHTCSCRNGGLC 1313
Query: 297 ------CRLQSGAWG------CCPFTQAVCCEDHIHC-CPAGFTCDTQKGTCEQGP--HQ 341
C G G C P C H+ C C TC+ GTC GP +
Sbjct: 1314 HASNGSCSCGLGWTGRHCELACPPGRYGAAC--HLECSCHNNSTCEPATGTCRCGPGFYG 1371
Query: 342 VPWMEKAPAHLSLPDPQAL---KRDVPCDNVSS---CPS---SDTCCQLTSGEWGCCPIP 392
P Q L + PCD +S CP+ C E GC P
Sbjct: 1372 QACEHPCPPGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFC------ERGCEPGS 1425
Query: 393 EAVCCSDHQHC-CPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDI-------GC 444
C HQ C C G C + V GL P R+ + D C
Sbjct: 1426 FGEGC--HQRCDCDGGAPC----------DPVTGLCLCPPGRSGATCNLDCRRGQFGPSC 1473
Query: 445 DQHTSCPVGQTCCPSLG 461
H C G C P G
Sbjct: 1474 TLHCDCGGGADCDPVSG 1490
Score = 58.5 bits (140), Expect = 2e-08
Identities = 115/516 (22%), Positives = 156/516 (30%), Gaps = 117/516 (22%)
Query: 101 RGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQA----- 155
RG H + C S + ++ C D C + TC + +DG C P+
Sbjct: 500 RGEHTLTEKFVCLDDSFGHDC-SLTCDD----CRNGGTCLLGLDG----CDCPEGWTGLI 550
Query: 156 ---SCCEDRV--HC-----CPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSS 205
+C D +C C +G CD V C P G + +
Sbjct: 551 CNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKK 610
Query: 206 VMCPDARSRCPDGSTCCELPSGKYG------CCPMPNATCCSDHLHCC-PQDTVCDLIQS 258
C + R RC C G YG C P CS+ C P CD
Sbjct: 611 CNCAN-RGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDG 669
Query: 259 KCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDH 318
C K + +C E C GY G W C
Sbjct: 670 SCSCKAGFRGE-------------RCQAE--CELGY----FGPGCWQACT---------- 700
Query: 319 IHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVS-SCPSSDT 377
CP G CD+ G C ++ PA D ++ P +C SS +
Sbjct: 701 ---CPVGVACDSVSGECG---------KRCPAGFQGED---CGQECPVGTFGVNCSSSCS 745
Query: 378 CCQL-TSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASL 436
C G G C P D + CP+G + + + A + P A L
Sbjct: 746 CGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGLGCQEICPACQHAARCD--PETGACL 803
Query: 437 SHPRDIGCDQHTSCPVG------QTCCPSLGGSWACCQLPHAVCCE-----DRQHCCPAG 485
P +G CP G QT C H C Q C G
Sbjct: 804 CLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTG 863
Query: 486 -------YTCNVKARSCEKEVVSAQPATFLARSPHVGVK-DVECGEGHF---CHDNQTCC 534
+ CN A + +S L + +VG + + +C +GHF C C
Sbjct: 864 HWGPDCSHPCNCSAGHGSCDAIS---GLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQC- 919
Query: 535 RDNRQGWACCPYRQGVCCADR-------RHCCPAGF 563
Q A C + G C H CPAGF
Sbjct: 920 ----QHGAACDHVSGACTCPAGWRGTFCEHACPAGF 951
Score = 53.1 bits (126), Expect = 7e-07
Identities = 78/300 (26%), Positives = 100/300 (33%), Gaps = 70/300 (23%)
Query: 19 RCPDGQF---CPVAC-CLDPGG---ASYSCCRPL----LDKWPTTLSRHLGGPCQVDAHC 67
RCP G++ C C CL+ G A+ +C P D T G C C
Sbjct: 1205 RCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGC 1264
Query: 68 SAGHSCIFTVSGTSSCCPFPEAVACGDG-----------HHC-CPRGFHCSADGRSCFQR 115
G +C V+GT C P V C G H C C G C A SC
Sbjct: 1265 GQGAACD-PVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCG 1323
Query: 116 SG-NNSVGAIQCPDSQF--------ECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCP 166
G + CP ++ C + STC G+ C P CE H CP
Sbjct: 1324 LGWTGRHCELACPPGRYGAACHLECSCHNNSTC-EPATGTCRCGPGFYGQACE---HPCP 1379
Query: 167 ---------------HGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDA 211
HGA CD + RC+ P G H + + + C D
Sbjct: 1380 PGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDC-DG 1438
Query: 212 RSRCPDGSTCCELPSGKYGCCPMPNATCCSD----------HLHC-CPQDTVCDLIQSKC 260
+ C + C P G+ G ATC D LHC C CD + +C
Sbjct: 1439 GAPCDPVTGLCLCPPGRSG------ATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQC 1492
Score = 51.2 bits (121), Expect = 3e-06
Identities = 143/630 (22%), Positives = 197/630 (31%), Gaps = 157/630 (24%)
Query: 17 GTRCPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGG--------PCQVDAHCS 68
G RC G P C P G C+ +D+ T H GG P C
Sbjct: 136 GGRCVPGSAQPCHC---PPGFQGPRCQYDVDECRT----HNGGCQHRCVNTPGSYLCECK 188
Query: 69 AGHSCIFTVSGTSSCCPFPEAVACGDG---HHC-----------CPRGFHCSADGRSCFQ 114
G F + S C + A G+G HHC C GF DGR C +
Sbjct: 189 PG----FRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHCVR 244
Query: 115 RSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGC-CPM-----PQASCCEDRVHC---- 164
RS C + C C +V G C C + CED C
Sbjct: 245 RS--------PCANRNGSC---MHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGL 293
Query: 165 --CPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCC 222
C HG +C+ G A R + S C
Sbjct: 294 AQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNS------------------C 335
Query: 223 ELPSG--KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKEN-ATTDLLTKLPAHTV 279
E +G +GC C+ CP+ D Q C+ ++ A + ++ +
Sbjct: 336 EANNGGCSHGCSHTSAGPLCT-----CPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNP 390
Query: 280 GDVKCDMEVSCPDGYTCCRLQSGAWGC-----CPFTQAVCCEDHIHC----------CPA 324
G +C C GY RL + GC C ++ C +H HC C A
Sbjct: 391 GGYEC----GCYAGY---RLSADGCGCEDVDECASSRGGC--EH-HCTNLAGSFQCSCEA 440
Query: 325 GFTCDTQKGTCEQGPHQVPWME---KAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQL 381
G+ + C P + P ++ + P LP L+ ++P +D
Sbjct: 441 GYRLHEDRRGC--SPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAE 498
Query: 382 TSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGL------EKMPARRAS 435
GE + E C D TC C+ G + GL E +
Sbjct: 499 LRGEH---TLTEKFVCLDDSFGHDCSLTC---DDCRNGGTCLLGLDGCDCPEGWTGLICN 552
Query: 436 LSHPRDI---GCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGY------ 486
+ P D C SC G TC G C+ P V + + CP GY
Sbjct: 553 ETCPPDTFGKNCSFSCSCQNGGTCDSVTG----ACRCPPGVSGTNCEDGCPKGYYGKHCR 608
Query: 487 -TCNVKARSCEKEVVSA---QPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWA 542
CN R + A P + R H+ G G C + C + + Q
Sbjct: 609 KKCNCANRGRCHRLYGACLCDPGLY-GRFCHLTCPPWAFGPG--CSEECQCVQPHTQS-- 663
Query: 543 CCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
C R G C C AGF RG +C
Sbjct: 664 -CDKRDGSC------SCKAGF----RGERC 682
Score = 29.6 bits (65), Expect = 8.2
Identities = 57/221 (25%), Positives = 70/221 (31%), Gaps = 31/221 (14%)
Query: 372 CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCP--QGYTCVAE--------GQCQRGSE 421
C S++ L C P C HC P QG C + G CQ
Sbjct: 123 CLSAECSASLCFHGGRCVPGSAQPC-----HCPPGFQGPRCQYDVDECRTHNGGCQHRCV 177
Query: 422 IVAGLEKMPARRASLSHPRDIGCDQHTSCPVG----QTCCPSLGGSWACCQL-PHAVCCE 476
G + H C SC +G Q C L + CQ P E
Sbjct: 178 NTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQE 237
Query: 477 DRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSP-HVGVKDVECGEGHFCHDNQTCCR 535
D +HC C + SC Q LAR HVG + +G C D C
Sbjct: 238 DGRHCVRRS-PCANRNGSCMHR---CQVVRGLARCECHVGYQ--LAADGKACEDVDECAA 291
Query: 536 DNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRRE 576
Q C QG + C AG+ A G +C R E
Sbjct: 292 GLAQCAHGCLNTQG----SFKCVCHAGYELGADGRQCYRIE 328
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 79.3 bits (194), Expect = 9e-15
Identities = 160/615 (26%), Positives = 204/615 (33%), Gaps = 156/615 (25%)
Query: 21 PDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGH-SCIFTVSG 79
P G+ CP+ CC + GG+ + + +W T G PC++ C GH C
Sbjct: 184 PPGECCPI-CCTE-GGSHWEHGQ----EWTTP-----GDPCRI-CRCLEGHIQC--RQRE 229
Query: 80 TSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC 139
+S CP+P G CCP C +GR RSG VG+ P S C + S
Sbjct: 230 CASLCPYPARPLPGT---CCPVCDGCFLNGRE--HRSGE-PVGSGD-PCSHCRCANGSVQ 282
Query: 140 CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDL-----------------VHTRCITPT 182
C + C P+P + CCP C+ + RC
Sbjct: 283 CEPLP----CPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQA 338
Query: 183 GTHPLAKKLPAQRTNRAVALSSSVMCP----------DARSRCPDGSTC----CELPSGK 228
G ++ T A+ S +CP + PDG C C+ K
Sbjct: 339 G-EVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPK 397
Query: 229 YGCCPMPNATC---CSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTV----GD 281
G P A C CCP C + +N T P H G
Sbjct: 398 CGAVLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTD---ADSPCHACHCQDGT 454
Query: 282 VKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFT--------CDTQKG 333
V C + V CP TC R QSG CCP E+ + F+ C Q+G
Sbjct: 455 VTCSL-VDCPPT-TCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEG 512
Query: 334 TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDN-VSSC-------PS-------SDTC 378
P P +AP LP C N S C PS SD C
Sbjct: 513 HAHCQPRPCP---RAPCAHPLP-------GTCCPNDCSGCAFGGKEYPSGADFPHPSDPC 562
Query: 379 --CQLTSGEWGC-------CPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKM 429
C+ SG C P PE V CCPQ C A C
Sbjct: 563 RLCRCLSGNVQCLARRCVPLPCPEPVLLPG--ECCPQ---CPAPAGCP------------ 605
Query: 430 PARRASLSHPRDIGCDQHTSCPVGQTC--CPSLGGSWACCQL--PHAVCCEDRQ-HCCPA 484
R +H R Q P G C C L GS +C +L P A C RQ CCP+
Sbjct: 606 ---RPGAAHAR----HQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPS 658
Query: 485 GYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACC 544
C + KE S + SP C EG + + C A C
Sbjct: 659 CDGCLYQG----KEFASGERFP----SPTAACHLCLCWEGSVSCEPKACAP------ALC 704
Query: 545 PY-RQGVCCADRRHC 558
P+ +G CC D C
Sbjct: 705 PFPARGDCCPDCDGC 719
Score = 58.2 bits (139), Expect = 2e-08
Identities = 132/592 (22%), Positives = 176/592 (29%), Gaps = 165/592 (27%)
Query: 20 CPDGQF------CPVACCLDPGGASYSCCRPLLDKWPTTLSR-----------HLGGPCQ 62
C DG CP C P CC + P + H PCQ
Sbjct: 450 CQDGTVTCSLVDCPPTTCARPQSGPGQCC----PRCPDCILEEEVFVDGESFSHPRDPCQ 505
Query: 63 VDAHCSAGHS-----------CIFTVSGTSSCCPFPEAVACGDGHHCCPRGF---HCSAD 108
+ C GH+ C + GT CCP + C G P G H S
Sbjct: 506 -ECRCQEGHAHCQPRPCPRAPCAHPLPGT--CCP-NDCSGCAFGGKEYPSGADFPHPSDP 561
Query: 109 GRSCFQRSGNNSVGA-----IQCPDSQF-------ECPDFSTC----------------- 139
R C SGN A + CP+ +CP + C
Sbjct: 562 CRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPP 621
Query: 140 ------CVMVDGSWGC--CPMPQASCCEDRVH-CCPHGAFCDLVHTRCITPTGTHPLAKK 190
C+ +DGS C P P A C R CCP CD C+ ++
Sbjct: 622 GDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPS---CD----GCLYQGKEFASGER 674
Query: 191 LPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQD 250
P+ + L C +GS CE + CP P CCP
Sbjct: 675 FPSPTAACHLCL------------CWEGSVSCEPKACAPALCPFPARG------DCCPDC 716
Query: 251 TVCDLIQSKCLSKEN-----ATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWG 305
C+ + LS + +L T L G V C P G + + SG
Sbjct: 717 DGCEYLGESYLSNQEFPDPREPCNLCTCLG----GFVTCGRRPCEPPGCSHPLIPSGH-- 770
Query: 306 CCPFTQAVCCEDHIHCCPAGFTCDTQKG------TCEQGPHQVPWMEKAPAHLSLPDPQA 359
CCP Q C H +G T TC++G + PA P P
Sbjct: 771 CCPTCQG--CRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPG- 827
Query: 360 LKRDVPCDNVSSCPSSDTC----------------------CQLTSGEWGCC-----PIP 392
PC CP +C C+ +G+ C P+P
Sbjct: 828 -----PC----FCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLP 878
Query: 393 EAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPV 452
+ ++ CCP+ C+A G+ E G +P A S G
Sbjct: 879 CKLQVTERGSCCPRCRGCLAHGE-----EHPEGSRWVPPDSACSSCVCHEGVVTCARIQC 933
Query: 453 GQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQP 504
+C G CC P CE G + A CE + QP
Sbjct: 934 ISSCAQPRQGPHDCC--PQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQP 983
Score = 47.4 bits (111), Expect = 4e-05
Identities = 133/583 (22%), Positives = 174/583 (29%), Gaps = 153/583 (26%)
Query: 17 GTRCPDGQFCPVACCLDPGGASYSCCRPLLD-KWPTTLSRHLGGPCQVDAHCSAGHSCIF 75
G CPD C G SY + D + P L LGG F
Sbjct: 710 GDCCPDCDGCEYL------GESYLSNQEFPDPREPCNLCTCLGG---------------F 748
Query: 76 TVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPD 135
G C P G H P G HC + C + G + PD P
Sbjct: 749 VTCGRRPCEP------PGCSHPLIPSG-HCCPTCQGC-RYHGVTTASGETLPD-----PL 795
Query: 136 FSTC--CVMVDGSWGCC--PMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKL 191
TC C +GS C P P A C H P FC + H+ C++ H ++
Sbjct: 796 DPTCSLCTCQEGSMRCQKKPCPPALC----PHPSPGPCFCPVCHS-CLSQGREHQDGEEF 850
Query: 192 PAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDT 251
S C RC G C + C P+P ++ CCP+
Sbjct: 851 EGPA-------GSCEWC-----RCQAGQVSCV----RLQCPPLPCKLQVTERGSCCPR-- 892
Query: 252 VCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQ 311
C CL+ + +P D C V TC R+Q C +
Sbjct: 893 -C----RGCLAHGEEHPEGSRWVPP----DSACSSCVCHEGVVTCARIQ------CISSC 937
Query: 312 AVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSS 371
A + CCP C+ + E G P + + P P+
Sbjct: 938 AQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEG------------ 985
Query: 372 CPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCV-AEGQCQRGSEIVAGLEKMP 430
P S C + CP P + QHCCP TC A C G + G E P
Sbjct: 986 -PPSLRCHRRQCPSLVGCP-PSQLLPPGPQHCCP---TCAEALSNCSEG---LLGSELAP 1037
Query: 431 ARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQ--LPHAVCCEDRQH-----CCP 483
D +C C L +W C P C +H CCP
Sbjct: 1038 P-------------DPCYTCQ-----CQDL--TWLCIHQACPELSCPLSERHTPPGSCCP 1077
Query: 484 AGYTCNVKARSC---EKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQG 540
C +SC +EV S + T V+ C C+ R
Sbjct: 1078 ---VCRAPTQSCVHQGREVASGERWT------------VDTCTSCSCMAGTVRCQSQR-- 1120
Query: 541 WACCPYRQG---VCCADRRHCCPAGFRCAARGTKCLRREAPRW 580
C P G CCP RC R C+ P +
Sbjct: 1121 --CSPLSCGPDKAPALSPGSCCP---RCLPRPASCMAFGDPHY 1158
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 74.7 bits (182), Expect = 2e-13
Identities = 142/570 (24%), Positives = 172/570 (30%), Gaps = 148/570 (25%)
Query: 67 CSAGHSC----IF-TVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSV 121
C + HSC +F T G+ SC P C CP GFH G +C Q ++
Sbjct: 229 CPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLP---CPEGFH----GPNCSQECRCHNG 281
Query: 122 GAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITP 181
G C G C P C + CP G F C
Sbjct: 282 GL----------------CDRFTGQCRCAPGYTGDRCREE---CPVGRFGQ----DCAET 318
Query: 182 TGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDG--STCCELP-----SGKYGCCPM 234
P A+ PA + C D CPDG C+ P C PM
Sbjct: 319 CDCAPDARCFPANGACLCEHGFTGDRCTDRL--CPDGFYGLSCQAPCTCDREHSLSCHPM 376
Query: 235 PNATCCSDH---LHC---CPQDTVCDLIQSKCLSKEN----ATTDLLTKLPAHT------ 278
C LHC CPQDT Q CL AT+ L P +T
Sbjct: 377 NGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCAS 436
Query: 279 -----VGDVKCDMEVSCPDGYTC------CRLQSGAWG-------CCPFTQAVCCEDHIH 320
V C SC + C C + G W C P T C
Sbjct: 437 LCPPDTYGVNCSARCSCENAIACSPIDGECVCKEG-WQRGNCSVPCPPGTWGFSCNASCQ 495
Query: 321 CCPAGFTCDTQKG--TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC 378
C C Q G TC G H AH LP P+ + C + C SD C
Sbjct: 496 CAHEA-VCSPQTGACTCTPGWHG--------AHCQLPCPKGQFGE-GCASRCDCDHSDGC 545
Query: 379 ------CQLTSGEWGC-----CP-------IPEAVCCSDHQHCCPQGYTCV-AEG----Q 415
CQ +G G CP C + C P+ CV A G
Sbjct: 546 DPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPS 605
Query: 416 CQRGSEIVA-GLEKMPARRA--SLSHPRDIGC---DQHTSCPVGQTCCPSLGGSWA---- 465
CQR + G +P + A S HP + C T Q C P G W
Sbjct: 606 CQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPP---GHWGENCA 662
Query: 466 -CCQLPHAVCC--EDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECG 522
CQ H C +D CP G+T + C A + + +CG
Sbjct: 663 QTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCS-----------QPCQCG 711
Query: 523 EGHFCHDNQTCCRDNRQGWACCPYRQGVCC 552
G CH C C P G C
Sbjct: 712 PGEKCHPETGAC-------VCPPGHSGAPC 734
Score = 55.1 bits (131), Expect = 2e-07
Identities = 96/404 (23%), Positives = 123/404 (30%), Gaps = 91/404 (22%)
Query: 12 AGLVAGTRCPD---GQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAH-- 66
AGL CP G C C GG + L P H C D +
Sbjct: 387 AGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSG-LCQCAPGYTGPHCASLCPPDTYGV 445
Query: 67 -CSAGHSCIFTVSGTSSCCPFPEAVACGDGH---HC---CPRG---FHCSADGRSCFQRS 116
CSA SC +C P C +G +C CP G F C+A + +
Sbjct: 446 NCSARCSC----ENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAV 501
Query: 117 GNNSVGAIQCPDS------QFECP--DFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHG 168
+ GA C Q CP F C AS C+ C H
Sbjct: 502 CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGC--------------ASRCD-----CDHS 542
Query: 169 AFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPS-- 226
CD VH RC G L V S++ C + + P+ C P
Sbjct: 543 DGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFR 602
Query: 227 ----------GKYG--CCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKL 274
G+YG C P C++H C P + C CL+ D
Sbjct: 603 GPSCQRSCQPGRYGKRCVPCK----CANHSFCHPSNGTC-----YCLAGWTG-PDCSQPC 652
Query: 275 PAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGC------------CPF-TQAVCCEDHIHC 321
P G+ C C G T C Q G+ C CP T C C
Sbjct: 653 PPGHWGE-NCAQTCQCHHGGT-CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQC 710
Query: 322 CPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVP 365
P G C + G C P AP + + +P + P
Sbjct: 711 GP-GEKCHPETGACVCPPGH----SGAPCRIGIQEPFTVMPTTP 749
Score = 36.6 bits (83), Expect = 0.067
Identities = 59/220 (26%), Positives = 73/220 (33%), Gaps = 46/220 (20%)
Query: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ---RGSEI 422
C N SSC C SG + C Q C P Y + +CQ +
Sbjct: 150 CGNNSSCDPKSGVCSCPSG------LQPPNCL---QPCTPGYYGPACQFRCQCHGAPCDP 200
Query: 423 VAGLEKMPARRASLSHPRDIGCDQHTS---CPVGQTCCPSLGGSWACCQLPHAVCCEDRQ 479
G PA R S D+ C Q TS CP +C GG + Q P C
Sbjct: 201 QTGACFCPAERTGPS--CDVSCSQGTSGFFCPSTHSC--QNGGVF---QTPQGSC----- 248
Query: 480 HCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC--HDNQTCCRDN 537
CP G+ + + C P F P+ ++ C G C Q C
Sbjct: 249 -SCPPGWMGTICSLPC--------PEGF--HGPNCS-QECRCHNGGLCDRFTGQCRCAPG 296
Query: 538 RQGWAC---CPY-RQGVCCADRRHCCPAGFRCAARGTKCL 573
G C CP R G CA+ C P RC CL
Sbjct: 297 YTGDRCREECPVGRFGQDCAETCDCAPDA-RCFPANGACL 335
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 73.2 bits (178), Expect = 6e-13
Identities = 157/617 (25%), Positives = 199/617 (32%), Gaps = 156/617 (25%)
Query: 20 CPD-----GQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGH-SC 73
CP+ G CP GG+ + + +W T G PC++ C GH C
Sbjct: 234 CPEPVLRPGHCCPTCQGCTEGGSHWEHGQ----EWTTP-----GDPCRI-CRCLEGHIQC 283
Query: 74 IFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFEC 133
+S CP+P G CCP C +GR RSG VG+ P S C
Sbjct: 284 --RQRECASLCPYPARPLPGT---CCPVCDGCFLNGRE--HRSGE-PVGSGD-PCSHCRC 334
Query: 134 PDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDL-----------------VHT 176
+ S C + C P+P + CCP C+ +
Sbjct: 335 ANGSVQCEPLP----CPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCV 390
Query: 177 RCITPTGTHPLAKKLPAQRTNRAVALSSSVMCP----------DARSRCPDGSTC----C 222
RC G ++ T A+ S +CP + PDG C C
Sbjct: 391 RCSCQAG-EVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVC 449
Query: 223 ELPSGKYGCCPMPNATC---CSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTV 279
+ K G P A C CCP C + +N T P H
Sbjct: 450 QDGVPKCGAVLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTD---ADSPCHAC 506
Query: 280 ----GDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFT-------- 327
G V C + V CP TC R QSG CCP E+ + F+
Sbjct: 507 HCQDGTVTCSL-VDCPPT-TCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQE 564
Query: 328 CDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDN-VSSC-------PS----- 374
C Q+G P P +AP LP C N S C PS
Sbjct: 565 CRCQEGHAHCQPRPCP---RAPCAHPLP-------GTCCPNDCSGCAFGGKEYPSGADFP 614
Query: 375 --SDTC--CQLTSGEWGC-------CPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIV 423
SD C C+ SG C P PE V CCPQ A C
Sbjct: 615 HPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPG--ECCPQCPAAPAPAGCP------ 666
Query: 424 AGLEKMPARRASLSHPRDIGCDQHTSCPVGQTC--CPSLGGSWACCQL--PHAVCCEDRQ 479
R +H R Q P G C C L GS +C +L P A C RQ
Sbjct: 667 ---------RPGAAHAR----HQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQ 713
Query: 480 -HCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNR 538
CCP+ C + KE S + SP C EG + + C
Sbjct: 714 GPCCPSCDGCLYQG----KEFASGERFP----SPTAACHLCLCWEGSVSCEPKACAP--- 762
Query: 539 QGWACCPY-RQGVCCAD 554
A CP+ +G CC D
Sbjct: 763 ---ALCPFPARGDCCPD 776
Score = 33.5 bits (75), Expect = 0.57
Identities = 84/360 (23%), Positives = 106/360 (29%), Gaps = 85/360 (23%)
Query: 134 PDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPA 193
PD T CV DG+ C P PH C
Sbjct: 111 PDACTACVCQDGAAHCGPQAHL----------PHCRGCS--------------------- 139
Query: 194 QRTNRAVALSSSVMCPDARS--RCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDT 251
N + PDA + RC +G+ C G CP P A CC HC P
Sbjct: 140 --QNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCPEPGA-CCP---HCKPG-- 191
Query: 252 VCDLIQSKCLSKENATTDLLTKLPAHTV----GDVKCDMEVSCPDGYTCCRLQSGAWGCC 307
CD + E T L + P V+C M + CP C CC
Sbjct: 192 -CDY---EGQLYEEGVTFLSSSNPCLQCTCLRSRVRC-MALKCPPS-PCPEPVLRPGHCC 245
Query: 308 PFTQAVCCEDHIH------CCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK 361
P Q C E H G C + C +G Q E A P P
Sbjct: 246 PTCQG-CTEGGSHWEHGQEWTTPGDPCRICR--CLEGHIQCRQRECASL---CPYPARPL 299
Query: 362 RDVPCDNVSSC-------------PSSDTC--CQLTSGEWGCCPIPEAVCCSDHQ----- 401
C C S D C C+ +G C P+P H
Sbjct: 300 PGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPG 359
Query: 402 HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG 461
CCP C +G + E E+ R S ++ C++ CPV P+ G
Sbjct: 360 QCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCS-CQAGEVSCEEQ-ECPVTPCALPASG 417
Score = 29.6 bits (65), Expect = 8.2
Identities = 44/163 (26%), Positives = 50/163 (30%), Gaps = 31/163 (19%)
Query: 17 GTRCP-DGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIF 75
GT CP D C P GA + P L R L G Q A C
Sbjct: 590 GTCCPNDCSGCAFGGKEYPSGADFPHPSD-----PCRLCRCLSGNVQCLARRCVPLPCPE 644
Query: 76 TVSGTSSCCP----FPEAVAC---GDGH-----HCCPRGFHCSADGRSCFQRSGNNSVGA 123
V CCP P C G H + P G C R C G+ S
Sbjct: 645 PVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPC----RRCLCLDGSVSCQR 700
Query: 124 IQCPDSQFECPDFSTCCVMVDG---------SWGCCPMPQASC 157
+ CP + P CC DG S P P A+C
Sbjct: 701 LPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAAC 743
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 65.9 bits (159), Expect = 1e-10
Identities = 152/679 (22%), Positives = 215/679 (31%), Gaps = 193/679 (28%)
Query: 20 CPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHL-----GGPCQVDAHCSA----- 69
C P + C+D G S+SC P T L HL PC DA CS
Sbjct: 359 CIAATCAPGSTCIDRVG-SFSCLCP---PGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTG 414
Query: 70 --------GHS----------CIFTVSGTSSCCPFPEAVACGDGHHC-CPRGF---HCSA 107
G+S C+ G S C + +C CP G+ C A
Sbjct: 415 STLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEA 474
Query: 108 DGRSCFQRS---GNNSVGAIQ-----CPD--------------SQFECPDFSTCCVMVDG 145
D C + G+ + + CP + C + + C +++G
Sbjct: 475 DHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNG 534
Query: 146 SWGCCPMPQAS---CCEDRVHC----CPHGAFCD----LVHTRCITPTGTHPLAKKLPAQ 194
+ C +P S C ED C C +G C H +C+ + P
Sbjct: 535 -FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLP-------GFEGPRC 586
Query: 195 RTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCD 254
+T LS CP G++C +LP + CP + C P +
Sbjct: 587 QTEVDECLSDP---------CPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAP-----N 632
Query: 255 LIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVC 314
L Q K + K D K CPD G+ GC P
Sbjct: 633 LCQPKQICK-----------------DQKDKANCLCPD---------GSPGCAPPEDNCT 666
Query: 315 CEDHIHC------CPAGFT---CDTQKGTCEQGP-------HQVPWMEKAPAHLSLPDPQ 358
C H HC C G+T C+ + G C P + P P
Sbjct: 667 CH-HGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPT 725
Query: 359 ALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEA--VCCSDHQHC----CPQGYTCVA 412
+ C + C + +C G + CP C + +C C G TCV
Sbjct: 726 CSEEMTACHS-GPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVN 784
Query: 413 EG-----QCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSC---PVGQTCCPSLGGSW 464
C G + G R S + D C +C P G C G +
Sbjct: 785 RPGTFSCLCAMGFQ---GPRCEGKLRPSCA---DSPCRNRATCQDSPQGPRCLCPTGYTG 838
Query: 465 ACCQLPHAVC----CEDRQHC----------CPAGYT---CNVKARSCEKEVVSAQPATF 507
CQ +C C HC C G+T CN+ SC+K +S
Sbjct: 839 GSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALS--QGID 896
Query: 508 LARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPA-----G 562
++ H G V+ G +FCH C P QG C D + C + G
Sbjct: 897 VSSLCHNGGLCVDSGPSYFCH--------------CPPGFQGSLCQDHVNPCESRPCQNG 942
Query: 563 FRCAARGTKCLRREAPRWD 581
C A+ + L + AP +D
Sbjct: 943 ATCMAQPSGYLCQCAPGYD 961
Score = 55.1 bits (131), Expect = 2e-07
Identities = 157/677 (23%), Positives = 206/677 (30%), Gaps = 193/677 (28%)
Query: 16 AGTRCPDG----QFCPVAC---CLDPGGASYSCCRPLLD--KWPTTLSRHLGGPCQVDAH 66
+GTRC + + P A C D GA + C P + + T + L PC V A
Sbjct: 544 SGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGA- 602
Query: 67 CSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQC 126
SC P A C CP GF G+ C ++ C
Sbjct: 603 ---------------SCLDLPGAFFC-----LCPSGF----TGQLCEVPLCAPNL----C 634
Query: 127 PDSQFECPDFS--TCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGT 184
Q C D C+ DGS GC P P+ +C HC CD + TG
Sbjct: 635 QPKQI-CKDQKDKANCLCPDGSPGCAP-PEDNCTCHHGHCQRSSCVCD------VGWTGP 686
Query: 185 HPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMP-NATCCSDH 243
A+ L + P C G TC PSG CP CS+
Sbjct: 687 ECEAE------------LGGCISAP-----CAHGGTCYPQPSGYNCTCPTGYTGPTCSEE 729
Query: 244 LHCC--------------PQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDV---KCDM 286
+ C P C S + +TD P G
Sbjct: 730 MTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTF 789
Query: 287 EVSCPDGYTCCRLQSGAWGCC---PFTQAVCCEDHIH----CCPAGFT---CDTQKGTCE 336
C G+ R + C P C+D CP G+T C T C
Sbjct: 790 SCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCA 849
Query: 337 QGP--HQVPWMEKAPA--------------HLSLPDPQALKRDVPCDNVSSCPSSDTCCQ 380
Q P ++ P+ +L L Q D S C + C
Sbjct: 850 QKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLC-- 907
Query: 381 LTSGEWGCCPIP---EAVCCSDHQH-C----CPQGYTCVAEG-----QCQRG------SE 421
+ SG C P + C DH + C C G TC+A+ QC G S+
Sbjct: 908 VDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSK 967
Query: 422 IVAGLEKMPARRASLSHPRDIGCDQHTSCPVG---------------QTC-------CPS 459
+ + P P+ G H +CP G Q C C S
Sbjct: 968 ELDACQSQPCHNHGTCTPKPGGF--HCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHS 1025
Query: 460 LGGSWACCQLP--HAVCCE---DRQHCCPA--GYTCNVKARSCEKEVVSAQPATFLARSP 512
L ++ C LP CE D H P G TC E + P F+ P
Sbjct: 1026 LANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTC---------EATAGSPLGFICHCP 1076
Query: 513 HVGVKDVECGEG------HFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCA 566
G + C H CH C + G+ P R CA C +G+
Sbjct: 1077 K-GFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGF---PPR----CA-----CLSGY--- 1120
Query: 567 ARGTKCLRREAPRWDAP 583
G CL AP+ P
Sbjct: 1121 -GGPDCLTPPAPKGCGP 1136
Score = 39.3 bits (90), Expect = 0.010
Identities = 107/478 (22%), Positives = 152/478 (31%), Gaps = 119/478 (24%)
Query: 199 AVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMP---NATC----CSDHLHCCPQDT 251
+V ++C C +G TC L G+ C P TC + C
Sbjct: 19 SVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGG 78
Query: 252 VCDLIQSKCLSKENATTD-----LLTKLPAHTVGDVKCDMEVSCPDGYTC----CRLQSG 302
C + L ++ + L T LP T + +E CP + C +Q+
Sbjct: 79 SCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQAS 138
Query: 303 A---WGCCP-----------FTQAVCCED---------HIHC-CPAGF---TCDTQKGTC 335
C P F A C + I C CP GF C+ C
Sbjct: 139 GRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNEC 198
Query: 336 EQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCP--SSDTCCQLTSG--------E 385
Q P P + H +L Q L CP C+L +G
Sbjct: 199 FQDPGPCP--KGTSCHNTLGSFQCL-----------CPVGQEGPRCELRAGPCPPRGCSN 245
Query: 386 WGCCPIPEAVCCSDHQHCCPQGY----------TCVAEGQCQRGSEIVAGLEK----MPA 431
G C + + H CP G+ CV+ QCQ G GL+ P
Sbjct: 246 GGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSH-QCQNGGTCQDGLDTYTCLCPE 304
Query: 432 RRASLSHPRDIG-CDQH--TSCPVGQTCCPSLGGSWACC--QLPHAVCCEDRQHC----C 482
D+ C+ C G TC S G C C E+ C C
Sbjct: 305 TWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATC 364
Query: 483 PAGYTC--NVKARSC------------EKEVVSAQPA---TFLARSPHVGVKDVECGEGH 525
G TC V + SC +++ +QP + +P G C G+
Sbjct: 365 APGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGY 424
Query: 526 ---FCHDNQTCCRDNRQGWACCPYRQGVCCADRR---HC-CPAGF---RCAARGTKCL 573
CH + C +QG + C + G C + +C CP G+ RC A +CL
Sbjct: 425 SGPTCHQDLDECLMAQQGPSPCEH--GGSCLNTPGSFNCLCPPGYTGSRCEADHNECL 480
>gi|38490568 keratin associated protein 10-4 [Homo sapiens]
Length = 401
Score = 64.3 bits (155), Expect = 3e-10
Identities = 93/392 (23%), Positives = 124/392 (31%), Gaps = 88/392 (22%)
Query: 204 SSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC---SDHLHCCPQDTVCDLIQSKC 260
S V P +R P CE + GC +CC S L CC Q C
Sbjct: 54 SLVCTPVSRVSSPCCPVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCASSPC----QQAC 109
Query: 261 LSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFT--QAVCCEDH 318
T + C + V C D +CC+ S CC + Q CC
Sbjct: 110 CVPVCCKTVCCKPV---------CCVPVCCGDS-SCCQQSSCQSACCTSSPCQQACCVP- 158
Query: 319 IHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDN--VSSCPSSD 376
I C P C +C Q + +S P QA+ PC + +SSC S
Sbjct: 159 ICCKPV---CSGISSSCCQ-------QSSCVSCVSSPCCQAVCEPSPCQSGCISSCTPS- 207
Query: 377 TCCQLTSGEWGCCP---------IP--------EAVCCSDHQHCCPQGY---TCVAEGQC 416
CCQ +S + CC +P + VC D CC Q C C
Sbjct: 208 -CCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSEDSSSCCQQSSCQPACCTSSPC 266
Query: 417 QRGSEIVAGLEKM---PARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAV 473
Q+ + + + P + C Q +SC CC S CC V
Sbjct: 267 QQACCVPVCCKPVCCKPVGSVPICSGASSLCCQQSSCQ--PACCTSSQSQQGCCV---PV 321
Query: 474 CCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTC 533
CC+ C P C+ + SC ++ S QPA C C
Sbjct: 322 CCKP-VSCVP---VCSGASSSCCQQ-SSCQPA---------------------CCTTSCC 355
Query: 534 CRDNRQGWACCPYRQGVCCADRRHCCPAGFRC 565
+ C P + CC CC C
Sbjct: 356 RPSSSVSLLCRPVCRPACCVPVPSCCAPTSSC 387
Score = 47.0 bits (110), Expect = 5e-05
Identities = 64/258 (24%), Positives = 75/258 (29%), Gaps = 39/258 (15%)
Query: 18 TRCPDGQFCPVACCLDP--GGASYSCCRPL----LDKWPTTLSRHLGGPCQVDAHCSAGH 71
T P Q C V C P G S SCC+ P + PCQ S
Sbjct: 147 TSSPCQQACCVPICCKPVCSGISSSCCQQSSCVSCVSSPCCQAVCEPSPCQSGCISSCTP 206
Query: 72 SCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFH---CSADGRSCFQRSGNNSVGAIQCPD 128
SC S +CC CC CS D SC Q+S P
Sbjct: 207 SCCQQSSCQPACCTSSSCQQACCVPVCCKTVCCKPVCSEDSSSCCQQSSCQPACCTSSPC 266
Query: 129 SQFECPDFS---TCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTH 185
Q C CC V GS C + CC+ C P C P
Sbjct: 267 QQACCVPVCCKPVCCKPV-GSVPICSGASSLCCQQS-SCQPACCTSSQSQQGCCVPVCCK 324
Query: 186 PLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTC--------CELPSGKYG--CCPMP 235
P+ S +C A S C S+C C PS C P+
Sbjct: 325 PV---------------SCVPVCSGASSSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVC 369
Query: 236 NATCCSDHLHCCPQDTVC 253
CC CC + C
Sbjct: 370 RPACCVPVPSCCAPTSSC 387
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 63.9 bits (154), Expect = 4e-10
Identities = 130/575 (22%), Positives = 190/575 (33%), Gaps = 136/575 (23%)
Query: 74 IFTVSGTSSCCPFPEAVACGDGHHCC---PRG-FHCSA--------DGRSCFQRSGNNSV 121
I + T+SC P A+ G H C P G +CS D R + S N+
Sbjct: 2454 IAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAY 2513
Query: 122 GAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASC--CEDRV-----------HCCPHG 168
+C + EC D+ C DG C CE+R C PHG
Sbjct: 2514 SEFECGNG--ECIDYQLTC---DGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHG 2568
Query: 169 AFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVM-CPDARSRCPDGSTCCELPSG 227
CD G + + + L V C RC DG TC
Sbjct: 2569 KLCD----------GENDCG--------DNSDELDCKVSTCATVEFRCADG-TC------ 2603
Query: 228 KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME 287
+P + C+ ++ C + C N KL T G ++C+
Sbjct: 2604 ------IPRSARCNQNIDCADASD-----EKNC---NNTDCTHFYKLGVKTTGFIRCNST 2649
Query: 288 VSCP------DGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAG------FTCDTQKGTC 335
C DG C S C P CE++ CP+G + CD QK C
Sbjct: 2650 SLCVLPTWICDGSNDCGDYSDELKC-PVQNKHKCEENYFSCPSGRCILNTWICDGQKD-C 2707
Query: 336 EQGPHQVPWMEKAPAH-LSLPDPQALKRDVPCDNVSSC----PSSDTCCQLTSGEWGCCP 390
E G + + + + + + CD C SD+ C G C
Sbjct: 2708 EDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSIC----GAITCAA 2763
Query: 391 IPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMP----ARRASLSH-----PRD 441
+ C + C P+ + C E C GS+ ++ P A + H P+
Sbjct: 2764 --DMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQ 2821
Query: 442 IGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDR-----QHCCPAGYTC-------- 488
CD C G P G + C C + R Q C + C
Sbjct: 2822 FVCDHDDDCGDGSDESPQCG--YRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 2879
Query: 489 -NVKARSCEKEVVSAQPATFLARS----PHVGVKD--VECGEG---HFCHDNQTCCRDNR 538
N K +S E+ S + F+ ++ P G+ D +CG+G CH N+ C
Sbjct: 2880 LNPKCKSAEQ---SCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNCHINE-CLSKKV 2935
Query: 539 QGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
G C Q + + + C P GF+ G C+
Sbjct: 2936 SG--CSQDCQDLPVSYKCKCWP-GFQLKDDGKTCV 2967
Score = 57.8 bits (138), Expect = 3e-08
Identities = 110/504 (21%), Positives = 163/504 (32%), Gaps = 135/504 (26%)
Query: 71 HSCIFTVSGTSSCCPFPEAVACGDGHHC-CPRGFHCSADGRSCFQRSGNNSVGAIQCPDS 129
H C+ G S C +A G H C CP F+ +AD R+C C S
Sbjct: 3275 HLCMINNGGCSHLC----LLAPGKTHTCACPTNFYLAADNRTCLS----------NCTAS 3320
Query: 130 QFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAK 189
QF C C + W C + D CP
Sbjct: 3321 QFRCKT-DKC---IPFWWKCDTVDDCGDGSDEPDDCP----------------------- 3353
Query: 190 KLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQ 249
C R +C G+ C LP+ + C + SD L+C
Sbjct: 3354 ---------------EFRCQPGRFQC--GTGLCALPA--FICDGENDCGDNSDELNC--- 3391
Query: 250 DT-VCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDM---EVSCPDGYTCCRLQSGAWG 305
DT VC Q KC + L GD + + E SC Y C+
Sbjct: 3392 DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHC-- 3449
Query: 306 CCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVP 365
++ C++ C A + K TC GPH+ + + +PD
Sbjct: 3450 ---ISKLWVCDEDPDCADASDEANCDKKTC--GPHEF----QCKNNNCIPDHWR------ 3494
Query: 366 CDNVSSCPSSDTCCQLTSGEWGC----CPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSE 421
CD+ + C + S E C C + + +C + C + C + C GS+
Sbjct: 3495 CDSQNDCSDN-------SDEENCKPQTCTLKDFLCANG--DCVSSRFWCDGDFDCADGSD 3545
Query: 422 IVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHC 481
R S +D C GQ C P+ W C ED + C
Sbjct: 3546 ---------ERNCETSCSKD-----QFRCSNGQ-CIPA---KWKCDGHEDCKYGEDEKSC 3587
Query: 482 CPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGW 541
PA TC+ +E + A A G + +C +G D T C++++
Sbjct: 3588 EPASPTCS------SREYICASDGCISASLKCNG--EYDCADGSDEMDCVTECKEDQ--- 3636
Query: 542 ACCPYRQGVCCADRRHCCPAGFRC 565
+R C ++ HC P + C
Sbjct: 3637 ----FR----CKNKAHCIPIRWLC 3652
Score = 53.9 bits (128), Expect = 4e-07
Identities = 121/516 (23%), Positives = 166/516 (32%), Gaps = 114/516 (22%)
Query: 26 CPVACCLDPGGASYSCC-RPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCC 84
C C PGG +C LLD+ TT C + + H C +G C
Sbjct: 805 CSTLCLAIPGGRVCACADNQLLDENGTT--------CTFNPGEALPHIC---KAGEFRC- 852
Query: 85 PFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQ--CPDSQFECPDFSTCCV- 141
HC + C D C S +SV CPD QF+C + C+
Sbjct: 853 ---------KNRHCIQARWKCDGDD-DCLDGSDEDSVNCFNHSCPDDQFKCQ--NNRCIP 900
Query: 142 ---MVDGSWGC---------------CPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG 183
+ DG+ C C + Q SC R C P CD C T
Sbjct: 901 KRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGR--CIPRAWLCDR-EDDCGDQTD 957
Query: 184 -----THPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCP--MPN 236
P + L +SS C D+ C DG S + GC N
Sbjct: 958 EMASCEFPTCEPLTQFVCKSGRCISSKWHC-DSDDDCGDG-------SDEVGCVHSCFDN 1009
Query: 237 ATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTV-----GDVKCDMEVSC- 290
CS C P CD + C + TK H+ + +C + +C
Sbjct: 1010 QFRCSSG-RCIPGHWACD-GDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV 1067
Query: 291 PDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCC--PAGFTCDTQKGTCEQGPHQVPWMEKA 348
PD + C G C + C I C F+C G C + KA
Sbjct: 1068 PDLWRC----DGEKDCEDGSDEKGCNGTIRLCDHKTKFSC-WSTGRC---------INKA 1113
Query: 349 PAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCP--- 405
D + + CD+ P C TS C PE +C + + CP
Sbjct: 1114 WVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTS----VCLQPEKLC--NGKKDCPDGS 1167
Query: 406 -QGYTC----VAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ-HTSCPVGQTCCPS 459
+GY C + G C +V P R S P + ++ + +C + C
Sbjct: 1168 DEGYLCDECSLNNGGCSNHCSVV------PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNH 1221
Query: 460 LGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
L S C Q H V C C G+ +V SC
Sbjct: 1222 LKCSQVCEQHKHTVKCS-----CYEGWKLDVDGESC 1252
Score = 44.3 bits (103), Expect = 3e-04
Identities = 107/497 (21%), Positives = 151/497 (30%), Gaps = 123/497 (24%)
Query: 67 CSAGHSCI---FTVSGTSSC--------CP----FPEAVACGDGHHCCPRGFHCSADGRS 111
C+ CI +G C CP P+ C HC + + C D
Sbjct: 3403 CTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDP-D 3461
Query: 112 CFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFC 171
C S + C +F+C + + C + W C S D +C P C
Sbjct: 3462 CADASDEANCDKKTCGPHEFQCKN-NNC---IPDHWRCDSQNDCSDNSDEENCKPQT--C 3515
Query: 172 DLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGST--CCELPSGK- 228
L C +SS C D C DGS CE K
Sbjct: 3516 TLKDFLCANGD------------------CVSSRFWC-DGDFDCADGSDERNCETSCSKD 3556
Query: 229 -----YGCCPMPNATCCSDHLHCC--PQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGD 281
G C +P C H C + C+ C S+E +
Sbjct: 3557 QFRCSNGQC-IPAKWKCDGHEDCKYGEDEKSCEPASPTCSSRE-----YICASDGCISAS 3610
Query: 282 VKCDMEVSCPDGYTCCRLQSGAWGC---CPFTQAVCCEDHIHCCPAGFTCD--------T 330
+KC+ E C DG S C C Q C++ HC P + CD +
Sbjct: 3611 LKCNGEYDCADG-------SDEMDCVTECKEDQ-FRCKNKAHCIPIRWLCDGIHDCVDGS 3662
Query: 331 QKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSS-----DTCCQLTSGE 385
+ CE+G + + +A L L V CD C + D C +
Sbjct: 3663 DEENCERGGN----ICRADEFLCNNSLCKLHFWV-CDGEDDCGDNSDEAPDMCVKFL--- 3714
Query: 386 WGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEI--VAGLEKMPARRASLSH----- 438
CP C +++ C C +C S+ G AR
Sbjct: 3715 ---CPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN 3771
Query: 439 ----PRDIGCDQHTSC------------PVGQTCCPSL---GGSWACCQLPHAVCCEDRQ 479
P D+ CD+ C P TC ++ G C Q+ +V C
Sbjct: 3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCR--- 3828
Query: 480 HCCPAGYTCNVKARSCE 496
C G+ N+K R CE
Sbjct: 3829 --CKPGFQRNMKNRQCE 3843
Score = 38.5 bits (88), Expect = 0.018
Identities = 88/417 (21%), Positives = 137/417 (32%), Gaps = 94/417 (22%)
Query: 20 CPDG---QFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFT 76
C DG + C +C D S C P KW C C G
Sbjct: 3540 CADGSDERNCETSCSKDQFRCSNGQCIPA--KWK----------CDGHEDCKYGED---- 3583
Query: 77 VSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDF 136
SC P C R + C++DG C S ++C + +++C D
Sbjct: 3584 ---EKSCEPASPT--------CSSREYICASDG--CISAS-------LKC-NGEYDCADG 3622
Query: 137 STCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRT 196
S V C Q C +++ HC P CD +H C+ + + R
Sbjct: 3623 SDEMDCVTE----CKEDQFRC-KNKAHCIPIRWLCDGIHD-CVDGSDEENCERGGNICRA 3676
Query: 197 NRAVALSSSVMCP------DARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQD 250
+ L ++ +C D C D S K+ CP C ++ C +
Sbjct: 3677 DE--FLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKF-LCPSTRPHRCRNNRICLQSE 3733
Query: 251 TVCDLIQSKC---LSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ-----SG 302
+C+ I +C +++ L K + C + P C RL S
Sbjct: 3734 QMCNGI-DECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSD 3792
Query: 303 AWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGT--CEQGPHQVPWMEKAPAHLSLPDPQAL 360
GC CED+++ C C+ K + C P Q
Sbjct: 3793 EQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCR----------------CKPGFQRN 3836
Query: 361 KRDVPCDNVSSCPSSDTC---CQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG 414
++ C++++ C TC C G + C VC + Q + TC+AEG
Sbjct: 3837 MKNRQCEDLNECLVFGTCSHQCINVEGSYKC------VCDQNFQE---RNNTCIAEG 3884
Score = 38.1 bits (87), Expect = 0.023
Identities = 70/347 (20%), Positives = 105/347 (30%), Gaps = 75/347 (21%)
Query: 257 QSKCLSKENATT--DLLTKLPA-HTVGDVKCDMEVSCPD-GYTCCRLQSGAWGCCPFTQA 312
++K LS+ + T+ D L+ + + H + D++ PD C + +G GC
Sbjct: 3233 KTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNG--GCSHLCLL 3290
Query: 313 VCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSC 372
+ H CP F TC + + + CD V C
Sbjct: 3291 APGKTHTCACPTNFYLAADNRTCLSNC--------TASQFRCKTDKCIPFWWKCDTVDDC 3342
Query: 373 PSS----DTC----CQLTSGEWGC----CPIPEAVC-----CSDHQ-------HCCPQG- 407
D C CQ G + C C +P +C C D+ H C G
Sbjct: 3343 GDGSDEPDDCPEFRCQ--PGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQ 3400
Query: 408 YTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACC 467
+ C +C + G + P + + C + C L W C
Sbjct: 3401 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKL---WVCD 3457
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC 527
+ P D +C TC C K+ C H+
Sbjct: 3458 EDPDCADASDEANCDKK--TCGPHEFQC---------------------KNNNCIPDHWR 3494
Query: 528 HDNQTCCRDNRQGWAC----CPYRQGVC----CADRRHCCPAGFRCA 566
D+Q C DN C C + +C C R C F CA
Sbjct: 3495 CDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCA 3541
Score = 32.7 bits (73), Expect = 0.97
Identities = 89/402 (22%), Positives = 132/402 (32%), Gaps = 83/402 (20%)
Query: 208 CPDARSRCPDGSTCCE-LPSGKYGC----CPMPNATCCSDHLHCCPQDTVCDLIQSKCLS 262
C AR +C C + C CP C ++ C P+ +CD C S
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNR--CIPKRWLCDGAND-CGS 913
Query: 263 KENATTDLLT----KLPAHTVGDVKC-------DMEVSC---PDGYTCCRLQSGAWGCCP 308
E+ + T ++ + G+ +C D E C D C + C P
Sbjct: 914 NEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPT----CEP 969
Query: 309 FTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWME-------KAPAHLSLPDPQALK 361
TQ VC C + + CD+ C G +V + + + +P A
Sbjct: 970 LTQFVCKSGR--CISSKWHCDSDDD-CGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACD 1026
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSE 421
D C + S + + GC C +C P + C E C+ GS+
Sbjct: 1027 GDNDCGDFSDEAQINCTKEEIHSPAGCNG--NEFQCHPDGNCVPDLWRCDGEKDCEDGSD 1084
Query: 422 IVAGLEKMPARRASLSHPRDIGCDQHT--SCPVGQTCCPSLGGSWACCQLPHAVCCEDR- 478
EK L CD T SC C + +W C + CED+
Sbjct: 1085 -----EKGCNGTIRL-------CDHKTKFSCWSTGRC---INKAWVC---DGDIDCEDQS 1126
Query: 479 -QHCCPAGYTCNVKARSCEKEV-VSAQPATFLARSPHVGVKDVECG--EGHFCHDNQTCC 534
+ C + + C C + V QP G KD G EG+ C + C
Sbjct: 1127 DEDDCDS-FLCGPPKHPCANDTSVCLQPEKLCN-----GKKDCPDGSDEGYLCDE----C 1176
Query: 535 RDNRQG----WACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
N G + P R G+ C+ CP G + C
Sbjct: 1177 SLNNGGCSNHCSVVPGR-GIVCS-----CPEGLQLNKDNKTC 1212
Score = 30.8 bits (68), Expect = 3.7
Identities = 68/297 (22%), Positives = 95/297 (31%), Gaps = 48/297 (16%)
Query: 26 CPVACCLDPGGASYSCCR-PLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCC 84
C C L+P GA+ C L L C++ C G CI G C
Sbjct: 4181 CEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLT--CENGGRCILNEKGDLRCH 4238
Query: 85 PFP--EAVACGDGHHC---CPRGFHC--SADGR---SCFQRSGNNSVGAIQCPDSQFECP 134
+P C + +HC C G C S GR SC + G C D C
Sbjct: 4239 CWPSYSGERC-EVNHCSNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCEDF---CQ 4294
Query: 135 DFSTCCVMVDGSWGCCPMPQ--ASCCEDRV--HCCPHGAFC---DLVHTRCITPT----- 182
+ TC V C P+ C+ V H C + C D C+ PT
Sbjct: 4295 NGGTCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGP 4354
Query: 183 -----------GTHPLAKK----LPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
G H + K + TN +A S C C +G TC P
Sbjct: 4355 KCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASS----CQLCDGYCYNGGTCQLDPET 4410
Query: 228 KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKC 284
C + P+ + D I ++ ++ L+T + +G V C
Sbjct: 4411 NVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTLITTLVIGLVLC 4467
Score = 30.0 bits (66), Expect = 6.3
Identities = 38/178 (21%), Positives = 62/178 (34%), Gaps = 27/178 (15%)
Query: 235 PNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGY 294
P C DH+ C Q +CD C + + D + ++E+ CP +
Sbjct: 34 PGEFLCHDHVTCVSQSWLCD-GDPDCPDDSDESLDTCPE-----------EVEIKCPLNH 81
Query: 295 TCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFT----CDTQKGTCEQGPHQVP-WMEKAP 349
C G C +Q +C + + CP G+ C C+Q Q M +
Sbjct: 82 IAC---LGTNKCVHLSQ-LC--NGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNS 135
Query: 350 AHLSLPDPQALKRD-VPCDNVSSCPSSDTC---CQLTSGEWGCCPIPEAVCCSDHQHC 403
D + D C + C TC C+ T G + C + + D++ C
Sbjct: 136 TRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSC 193
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 63.2 bits (152), Expect = 7e-10
Identities = 137/623 (21%), Positives = 192/623 (30%), Gaps = 143/623 (22%)
Query: 30 CCLDPGGASY--SCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCI--FTVSGTSSC-- 83
C ++ GAS CC L W + R C++D C+ G + + T + C
Sbjct: 821 CEVNLQGASLRSECCATLGAAWGSPCER-----CEIDPACARGFARMTGVTCDDVNECES 875
Query: 84 ----CPFPEAVACGDGHHC-CPRGFHCSADGR--------SCFQRSGNNSVGAIQCPDSQ 130
CP V C CP G A GR CF R + G + P
Sbjct: 876 FPGVCPNGRCVNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECG-VTLPGKY 934
Query: 131 FECPDFSTCCVMVDGSWG----CCPMPQASCCEDRVHCCPHG---AFCDLVHTRCI-TPT 182
CC + WG CP P++ + CP G A D + R
Sbjct: 935 ----RMDVCCCSIGAVWGVECEACPDPESL---EFASLCPRGLGFASRDFLSGRPFYKDV 987
Query: 183 GTHPLAKKLPAQRTNRAVALSSSVMCP-----DARSR-CPDGSTCCELPS--GKYGCCPM 234
+ L T R S C DA+ R C D C P G+ C
Sbjct: 988 NECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNT 1047
Query: 235 PNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLT---KLPAHTVGDVKCDMEVSCP 291
P + C C P ++ C+ + D L +T G KC CP
Sbjct: 1048 PGSFECE----CFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTDGSYKCQ----CP 1099
Query: 292 DGY------TCCR---LQSGAWGCCPFTQAVCCEDHIHC-CPAGFT-------------C 328
G+ T C S + G CP Q V C C AGF C
Sbjct: 1100 PGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINEC 1159
Query: 329 DTQKGTCE------QGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLT 382
Q G C+ +G ++ + + +PD +A C +V C + C
Sbjct: 1160 RVQNGGCDVHCINTEGSYRCSCGQ---GYSLMPDGRA------CADVDECEENPRVCD-- 1208
Query: 383 SGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPR-- 440
G P C D P TCV +C I + + + + H +
Sbjct: 1209 QGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQLG 1268
Query: 441 ------DIGCDQHTSCPVG------QTCCPSLGGSWACCQLPHAVC----CEDRQHCCPA 484
GC C VG C ++ GS++C LP V C D C
Sbjct: 1269 YMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQ 1328
Query: 485 GYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACC 544
+ C+ + + S + G+G FC D C
Sbjct: 1329 EHRCSPRGDCLN-----------VPGSYRCTCRQGFAGDGFFCEDRDECA---------- 1367
Query: 545 PYRQGVCCADRRHC--CPAGFRC 565
+ V D C P G+RC
Sbjct: 1368 ---ENVDLCDNGQCLNAPGGYRC 1387
Score = 54.3 bits (129), Expect = 3e-07
Identities = 139/607 (22%), Positives = 193/607 (31%), Gaps = 175/607 (28%)
Query: 31 CLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHC-----------------SAGHSC 73
C P G +Y+ + SR PCQ +A C S G +C
Sbjct: 1746 CECPAGFNYNSILLACEDVDECGSRE--SPCQQNADCINIPGSYRCKCTRGYKLSPGGAC 1803
Query: 74 IFTVSGTSSCCPFPEAVACGD------GHHC-CPRGFHCSADGRSCF-------QRSGN- 118
+ G + C P + GD + C C RGF SAD C Q GN
Sbjct: 1804 V----GRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNG 1859
Query: 119 ---NSVGAIQC-------PDSQFECPDFSTCCVMVDG--SWGCCPMPQAS---CCEDRVH 163
N +G+ C +C DF C +V +G C S C+D
Sbjct: 1860 TCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFE 1919
Query: 164 CCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDA----RSRCPDGS 219
G C + C++ GT LP T + + S +CP C D
Sbjct: 1920 LTADGKNC-VDTNECLSLAGT-----CLPG--TCQNLEGSFRCICPPGFQVQSDHCIDID 1971
Query: 220 TCCELPS-----------GKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATT 268
C E P+ G + C P SD+ H C D QS C ++ A
Sbjct: 1972 ECSEEPNLCLFGTCTNSPGSFQCL-CPPGFVLSDNGHRC-----FDTRQSFCFTRFEAGK 2025
Query: 269 DLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSG-AWGCCPFTQAVCCEDHIHCCPAGFT 327
+ K A +C CC + G WG D CP
Sbjct: 2026 CSVPK--AFNTTKTRC-----------CCSKRPGEGWG-----------DPCELCP---- 2057
Query: 328 CDTQKGTCEQGPHQVPWMEKAP-AHLSLPDPQALKRDVP--CDNVSSCPSSDTCCQLTSG 384
Q+G+ + E P H ++P P + DV +N C ++ C T G
Sbjct: 2058 ---QEGS-------AAFQELCPFGHGAVPGPDDSREDVNECAENPGVC--TNGVCVNTDG 2105
Query: 385 EWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGC 444
+ C CP GY S G+ + S+ HP C
Sbjct: 2106 SFRC--------------ECPFGY-----------SLDFTGINCVDTDECSVGHP----C 2136
Query: 445 DQHTSCPVGQTCCPSLGGSWACC----QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVV 500
Q TC +GG C + + CED C C + + E +
Sbjct: 2137 GQ-------GTCTNVIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYL 2189
Query: 501 SAQPATFLARSPHVGVKDV-ECGEG-HFCHDNQTCCRDNRQGWAC-CP------YRQGVC 551
PA + R +DV EC +G CH C++ +AC CP G
Sbjct: 2190 CTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEG 2249
Query: 552 CADRRHC 558
C D C
Sbjct: 2250 CTDDNEC 2256
Score = 53.5 bits (127), Expect = 5e-07
Identities = 133/616 (21%), Positives = 186/616 (30%), Gaps = 147/616 (23%)
Query: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGF------HCSADGRSCFQ 114
C D G +C T G+ C C GH +G CS C
Sbjct: 1075 CARDPLLCRGGTCTNT-DGSYKC-------QCPPGHELTAKGTACEDIDECSLSDGLCPH 1126
Query: 115 RSGNNSVGAIQC---------PDSQFECPDFSTC----------CVMVDGSWGCCP---- 151
N +GA QC PD Q C D + C C+ +GS+ C
Sbjct: 1127 GQCVNVIGAFQCSCHAGFQSTPDRQ-GCVDINECRVQNGGCDVHCINTEGSYRCSCGQGY 1185
Query: 152 --MPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCP 209
MP C D C + CD H C G H R + + P
Sbjct: 1186 SLMPDGRACADVDECEENPRVCDQGH--CTNMPGGH------------RCLCYDGFMATP 1231
Query: 210 DARSRCPDGSTC-----------CELPSGKYGC-CPM-----PNATCCSDHLHCCPQDTV 252
D R+ C D C CE G + C C + AT CSD C
Sbjct: 1232 DMRT-CVDVDECDLNPHICLHGDCENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
Query: 253 CDLIQSKCLSKENATTDLLTKLPAHTVGDVKC-DMEVSCPDGYTC-----CRLQSGAWGC 306
CD + CL+ + + LP +C D++ + C C G++ C
Sbjct: 1291 CDS-HASCLNIPGSFS--CRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRC 1347
Query: 307 CPFT----QAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKR 362
CED C CD G C P + + DP R
Sbjct: 1348 TCRQGFAGDGFFCEDRDECAENVDLCDN--GQCLNAPGGY----RCECEMGF-DPTEDHR 1400
Query: 363 DVPCDNVSSCPSSDTCC-------------------QLTSGEWGCCPIPEAVCCSDHQHC 403
C +V C + C +L G C I E C+D +C
Sbjct: 1401 --ACQDVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDINE---CADPVNC 1455
Query: 404 C-------PQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPR-DIGCDQHTSCPVGQT 455
P Y C + V ++ +H R D G VG T
Sbjct: 1456 INGVCINTPGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVT 1515
Query: 456 ---CCPSLGGSWA-CCQLPHAVCCEDRQHCCPA--GYTCNVKARSCEKEVVSAQPATFLA 509
CC SLG +W C+L + + CP G+ N + +++ Q L
Sbjct: 1516 RASCCCSLGRAWGNPCELCPMANTTEYRTLCPGGEGFQPN-RITVILEDIDECQELPGLC 1574
Query: 510 RSPH----VGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--------CADRRH 557
+ G EC G+ ++ C D + C G+C +
Sbjct: 1575 QGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDE----CSTHSGICGPGTCYNTLGNYTC 1630
Query: 558 CCPAGFRCAARGTKCL 573
CPA + G C+
Sbjct: 1631 VCPAEYLQVNGGNNCM 1646
Score = 50.1 bits (118), Expect = 6e-06
Identities = 114/534 (21%), Positives = 172/534 (32%), Gaps = 132/534 (24%)
Query: 73 CIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQC------ 126
C+ T CPF ++ G +C CS G C Q + N +G +C
Sbjct: 2100 CVNTDGSFRCECPFGYSLDF-TGINCVDTD-ECSV-GHPCGQGTCTNVIGGFECACADGF 2156
Query: 127 -PDSQFECPDFSTC----------CVMVDGSWGC-CPMPQA------------SCCEDRV 162
P C D C C +GS+ C CP C + +
Sbjct: 2157 EPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQ 2216
Query: 163 HCCPHGAFC-DLVHT-RCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGST 220
C G C +L+ T C+ P G PL T+ + +C + R GS
Sbjct: 2217 DCHARGMECKNLIGTFACVCPPGMRPLPGSGEGC-TDDNECHAQPDLCVNGRCVNTAGSF 2275
Query: 221 CCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVG 280
C+ G P P T C D +++Q+ C S +++++ +T+ G
Sbjct: 2276 RCDCDEGFQ---PSPTLTECHDIRQ---GPCFAEVLQTMCRSL-SSSSEAVTRAECCCGG 2328
Query: 281 D----VKCDM---------EVSCP--DGYTC-------CRLQSGAWGCCPFTQAVCCEDH 318
+C++ CP GYT CR+ + C + +
Sbjct: 2329 GRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHL---CAHGECINSLGS 2385
Query: 319 IHC-CPAGFTCDTQKGTC------EQGPHQVPWM---EKAPAHLSLPDPQALKRDV-PCD 367
C C AG+T D TC Q P ++ K S P L+ D C
Sbjct: 2386 FRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCK 2445
Query: 368 NVSSCPSSDTCCQL----TSGEWGC-CP----------IPEAVC------CSDHQHC--- 403
++ C S CQ T G + C CP C C H HC
Sbjct: 2446 DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNT 2505
Query: 404 -------CPQGYTCVAEG-------------QCQRGSEIVAGLEKMPARRASLSHPRDIG 443
C QG+T V+ G +CQ G + G + + H +
Sbjct: 2506 PGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQLGGYRCSCPQGFTQHSQWAQ 2565
Query: 444 CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEK 497
C C + C GS +C C CP+G+ + C++
Sbjct: 2566 CVDENECALSPPTC----GSASCRNTLGGFRC-----VCPSGFDFDQALGGCQE 2610
Score = 49.7 bits (117), Expect = 8e-06
Identities = 103/481 (21%), Positives = 137/481 (28%), Gaps = 161/481 (33%)
Query: 93 GDGHHCCPRGFHCSADGRSCF-------------QRSGNNSVGAIQCP-----DSQF--- 131
G H C GF A R+C Q + N+ G+ +C +S F
Sbjct: 1007 GSFHCACAGGFALDAQERNCTDIDECRISPDLCGQGTCVNTPGSFECECFPGYESGFMLM 1066
Query: 132 -ECPDFSTC-----------CVMVDGSWGC-CP-----MPQASCCEDRVHCCPHGAFCDL 173
C D C C DGS+ C CP + + CED C C
Sbjct: 1067 KNCMDVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCP- 1125
Query: 174 VHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTC----------CE 223
H +C+ G + Q T PD R C D + C C
Sbjct: 1126 -HGQCVNVIGAFQCSCHAGFQST------------PD-RQGCVDINECRVQNGGCDVHCI 1171
Query: 224 LPSGKYGCCP------MPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAH 277
G Y C MP+ C+D C VCD Q C T +P
Sbjct: 1172 NTEGSYRCSCGQGYSLMPDGRACADVDECEENPRVCD--QGHC-----------TNMP-- 1216
Query: 278 TVGDVKC---DMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKG- 333
G +C D ++ PD TC + C +C F C Q G
Sbjct: 1217 --GGHRCLCYDGFMATPDMRTCVDVDE-----CDLNPHICLHGDCENTKGSFVCHCQLGY 1269
Query: 334 -------------TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSC---PSSDT 377
CE G H CD+ +SC P S +
Sbjct: 1270 MVRKGATGCSDVDECEVGGHN------------------------CDSHASCLNIPGSFS 1305
Query: 378 CCQLTSGEWGCCP--IPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRAS 435
C C P + + C D C Q + C G C V G + R+
Sbjct: 1306 C--------RCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLN----VPGSYRCTCRQGF 1353
Query: 436 LSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
C+ C C + C P CE C G+ R+C
Sbjct: 1354 AGD--GFFCEDRDECAENVDLC----DNGQCLNAPGGYRCE-----CEMGFDPTEDHRAC 1402
Query: 496 E 496
+
Sbjct: 1403 Q 1403
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/125 (28%), Positives = 48/125 (38%), Gaps = 17/125 (13%)
Query: 456 CCPSLGGSWAC-CQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPH- 513
CC ++G +W C+L C + H C G+ N+ +C+ +V Q L +
Sbjct: 210 CCATVGRAWGLPCEL-----CPAQPHPCRRGFIPNIHTGACQ-DVDECQAVPGLCQGGSC 263
Query: 514 ---VGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCAD------RRHCCPAGFR 564
VG C GH D+ C D R G G C D RR CC R
Sbjct: 264 VNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGR 323
Query: 565 CAARG 569
C A G
Sbjct: 324 CWAAG 328
Score = 45.4 bits (106), Expect = 1e-04
Identities = 106/498 (21%), Positives = 141/498 (28%), Gaps = 150/498 (30%)
Query: 16 AGTRCPDGQFC---PVAC----CLDPGGASYSCCRPLLDKWPTTLSRH--LGGPCQVDA- 65
+G C D C P C C++ G+ C PT H GPC +
Sbjct: 2246 SGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVL 2305
Query: 66 --HCSAGHSCIFTVSGTSSCC-------------PFPEAVACGDGHHCCPRGFHCSADGR 110
C + S V+ CC P P A CP G +A+GR
Sbjct: 2306 QTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAY---RKLCPHGSGYTAEGR 2362
Query: 111 S----------CFQRSGNNSVGAIQC-------PDSQFE-CPDFSTC----------CVM 142
C NS+G+ +C PD+ C D C C
Sbjct: 2363 DVDECRMLAHLCAHGECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKN 2422
Query: 143 VDGSWGC-CPM-----PQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRT 196
GS+ C CP C+D C C + C+ G + P T
Sbjct: 2423 TKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNCQFL---CVNTVGAFTC--RCPPGFT 2477
Query: 197 NRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCD-- 254
A + C C C P G + C T S H C CD
Sbjct: 2478 QHHQACFDNDECSAQPGPCGAHGHCHNTP-GSFRCECHQGFTLVSSG-HGCEDVNECDGP 2535
Query: 255 -LIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCC------ 307
Q C ++ +G +C SCP G+T Q W C
Sbjct: 2536 HRCQHGCQNQ---------------LGGYRC----SCPQGFT----QHSQWAQCVDENEC 2572
Query: 308 ----PFTQAVCCEDHI---HC-CPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQA 359
P + C + + C CP+GF D G C++
Sbjct: 2573 ALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQE---------------------- 2610
Query: 360 LKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRG 419
V C C + C P C CPQGY +G C G
Sbjct: 2611 ---------VDECAGRRGPCS-----YSCANTPGGFLCG-----CPQGYFRAGQGHCVSG 2651
Query: 420 SEIVAGLEKMPARRASLS 437
G + P + LS
Sbjct: 2652 LGFSPGPQDTPDKEELLS 2669
Score = 44.7 bits (104), Expect = 2e-04
Identities = 124/572 (21%), Positives = 168/572 (29%), Gaps = 163/572 (28%)
Query: 75 FTVSGTSSCCPFPEAVA-----CGDGH--------HC-CPRGFHCSADGRSCFQRSGNNS 120
F V+ C F E C GH HC C GF +ADG++C + S
Sbjct: 1876 FVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLS 1935
Query: 121 VGAIQCPDSQFECPDFSTCCVMVDGSWGC-CP---MPQASCCEDRVHCCPHGAFCDLVHT 176
+ P + C ++GS+ C CP Q+ C D C C +
Sbjct: 1936 LAGTCLPGT----------CQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLC--LFG 1983
Query: 177 RCITPTGTHPLAKKLPAQRTNRAVALSSSVMCP------DARSRCPDGSTCCELPSGKYG 230
C G S +CP D RC D + G
Sbjct: 1984 TCTNSPG-------------------SFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAG 2024
Query: 231 CCPMPNA-------TCCS--------DHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLP 275
C +P A CCS D CPQ+ Q C A P
Sbjct: 2025 KCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSA-AFQELCPFGHGAVPG-----P 2078
Query: 276 AHTVGDVK--CDMEVSCPDGYTCCRLQSGAWGC-CPFTQA-----VCCEDHIHCCPAGFT 327
+ DV + C +G C G++ C CPF + + C D C G
Sbjct: 2079 DDSREDVNECAENPGVCTNG--VCVNTDGSFRCECPFGYSLDFTGINCVDTDE-CSVGHP 2135
Query: 328 CDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQL----TS 383
C +GTC + + E A A P + C+++ C + C T
Sbjct: 2136 CG--QGTC---TNVIGGFECACADGFEPGLM-----MTCEDIDECSLNPLLCAFRCHNTE 2185
Query: 384 GEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG-QCQRGSEIVAGLEKMPARRASLSHPRDI 442
G + C CP GYT +G C+ E G + AR
Sbjct: 2186 GSYLC--------------TCPAGYTLREDGAMCRDVDECADGQQDCHARGME------- 2224
Query: 443 GCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSA 502
C +L G++AC P C C+ + C
Sbjct: 2225 --------------CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVN 2270
Query: 503 QPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--------CAD 554
+F +C EG T C D RQG Q +C
Sbjct: 2271 TAGSFRC----------DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVT 2320
Query: 555 RRHCCPAGFR--------CAARGTKCLRREAP 578
R CC G R C GT R+ P
Sbjct: 2321 RAECCCGGGRGWGPRCELCPLPGTSAYRKLCP 2352
Score = 43.1 bits (100), Expect = 7e-04
Identities = 144/662 (21%), Positives = 207/662 (31%), Gaps = 164/662 (24%)
Query: 23 GQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSS 82
GQ C CL+ G+ + C+ D + T +C + C+ +++GT
Sbjct: 1895 GQVCRFGHCLNTAGSFHCLCQ---DGFELTAD---------GKNCVDTNECL-SLAGT-- 1939
Query: 83 CCPFPEAVACGDGHHCCPRGF-----------HCSADGRSCFQRSGNNSVGAIQC----- 126
C P G CP GF CS + C + NS G+ QC
Sbjct: 1940 CLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPG 1999
Query: 127 ---PDSQFECPDFSTCCVMVDGSWGCCPMPQA-------SCCE--------DRVHCCPH- 167
D+ C D G C +P+A CC D CP
Sbjct: 2000 FVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQE 2059
Query: 168 --GAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELP 225
AF +L P G H R + + +C + DGS CE P
Sbjct: 2060 GSAAFQEL------CPFG-HGAVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECP 2112
Query: 226 SG------KYGCC---------PMPNATC----------CSDH-----LHCCPQDTVCDL 255
G C P TC C+D + C C L
Sbjct: 2113 FGYSLDFTGINCVDTDECSVGHPCGQGTCTNVIGGFECACADGFEPGLMMTCEDIDECSL 2172
Query: 256 IQSKCLSK-ENATTDLLTKLPA-HTVGD--VKCDMEVSCPDGYTCCRLQS-------GAW 304
C + N L PA +T+ + C C DG C + G +
Sbjct: 2173 NPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGMECKNLIGTF 2232
Query: 305 GC--------CPFTQAVCCEDH-IHCCP------------AGFTCDTQKGTCEQGPHQVP 343
C P + C +D+ H P F CD C++G P
Sbjct: 2233 ACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCD-----CDEGFQPSP 2287
Query: 344 WMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDT---CCQLTSGEWG----CCPIPEAVC 396
+ + P + + + C ++SS + T CC WG CP+P
Sbjct: 2288 TLTECHDIRQGPCFAEVLQTM-CRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGT-- 2344
Query: 397 CSDHQHCCPQGYTCVAEG----QCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPV 452
S ++ CP G AEG +C+ + + A E + + + H C +
Sbjct: 2345 -SAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCH-----CQAGYTPDA 2398
Query: 453 GQTCCPSLGGSWACCQLPH--AVCCEDRQH----CCPAGYTCNVKARSCE--KEVVSAQP 504
T C + C Q+P C++ + CP GY R+C+ E S Q
Sbjct: 2399 TATTCLDMD---ECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQH 2455
Query: 505 ATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRR-HCCPAGF 563
VG C G H C DN + C + G C A H P F
Sbjct: 2456 NCQFLCVNTVGAFTCRCPPGFTQH--HQACFDNDE----CSAQPGPCGAHGHCHNTPGSF 2509
Query: 564 RC 565
RC
Sbjct: 2510 RC 2511
Score = 43.1 bits (100), Expect = 7e-04
Identities = 76/329 (23%), Positives = 99/329 (30%), Gaps = 72/329 (21%)
Query: 66 HCSAGHSCIFTVSGTSSCC---------PFPEAVAC----GDGHHCCPRGFHCSADGRSC 112
HC AG +T T++ C P P C G CPRG+ DGR+C
Sbjct: 2389 HCQAG----YTPDATATTCLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTC 2444
Query: 113 FQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGC-CP---MPQASCCEDRVHCCPHG 168
+C Q C CV G++ C CP C D C
Sbjct: 2445 KDLD--------ECTSRQHNC---QFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493
Query: 169 AFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARS-----RCPDGSTCCE 223
C H C H + +SS C D RC G C+
Sbjct: 2494 GPCG-AHGHC------HNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG---CQ 2543
Query: 224 LPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVK 283
G Y C T S C ++ C L C S +T+G +
Sbjct: 2544 NQLGGYRCSCPQGFTQHSQWAQCVDENE-CALSPPTCGSAS----------CRNTLGGFR 2592
Query: 284 CDMEVSCPDGYTCCRLQSGAWGC-----CPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQG 338
C CP G+ GC C + C + P GF C +G G
Sbjct: 2593 C----VCPSGFD---FDQALGGCQEVDECAGRRGPCSYSCAN-TPGGFLCGCPQGYFRAG 2644
Query: 339 P-HQVPWMEKAPAHLSLPDPQALKRDVPC 366
H V + +P PD + L C
Sbjct: 2645 QGHCVSGLGFSPGPQDTPDKEELLSSEAC 2673
Score = 39.7 bits (91), Expect = 0.008
Identities = 111/512 (21%), Positives = 157/512 (30%), Gaps = 130/512 (25%)
Query: 26 CPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCP 85
C C++ G + C P PT + C CI VSG C
Sbjct: 458 CHHGDCVNIPGTYHCRCYPGFQATPTRQA------------CVDVDECI--VSG--GLCH 501
Query: 86 FPEAVACGDGHHC-CPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC----C 140
V C C GF S DG++C + EC + C C
Sbjct: 502 LGRCVNTEGSFQCVCNAGFELSPDGKNCVDHN---------------ECATSTMCVNGVC 546
Query: 141 VMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAV 200
+ DGS+ C C+ P G +C + C TP G + + R
Sbjct: 547 LNEDGSFSC-------LCKPGFLLAPGGHYC-MDIDECQTP-GICVNGHCTNTEGSFRCQ 597
Query: 201 ALSSSVMCPDARSRCPD---GSTCCELPSGKYGCCPMP-------NATCCSDHLH----- 245
L + D R C D STC + + G C P + CC++ H
Sbjct: 598 CLGGLAVGTDGRV-CVDTHVRSTC--YGAIEKGSCARPFPGTVTKSECCCANPDHGFGEP 654
Query: 246 --CCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGA 303
CP + Q+ C S TTD + + D EV C +G C G+
Sbjct: 655 CQLCPAKDSAE-FQALCSSGLGITTD------GRDINECALDPEV-CANG--VCENLRGS 704
Query: 304 WGC-CPF-----TQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDP 357
+ C C C D C CD G C+ P + P
Sbjct: 705 YRCVCNLGYEAGASGKDCTDVDECALNSLLCD--NGWCQNSPGS--YSCSCPPGFHFWQD 760
Query: 358 QALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ 417
+ +DV D S P C+ +G + C C P G C+ +
Sbjct: 761 TEICKDV--DECLSSPCVSGVCRNLAGSYTC-------KCGPGSRLDPSGTFCLDSTKGT 811
Query: 418 RGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWAC----CQLPHA- 472
+I ++ + ASL CC +LG +W C++ A
Sbjct: 812 CWLKIQESRCEVNLQGASLR----------------SECCATLGAAWGSPCERCEIDPAC 855
Query: 473 ---------VCCEDRQHC------CPAGYTCN 489
V C+D C CP G N
Sbjct: 856 ARGFARMTGVTCDDVNECESFPGVCPNGRCVN 887
Score = 36.2 bits (82), Expect = 0.087
Identities = 118/570 (20%), Positives = 178/570 (31%), Gaps = 130/570 (22%)
Query: 63 VDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFH--------CSADGRSCFQ 114
VD H + +C + S PFP V + CC H C A + FQ
Sbjct: 612 VDTHVRS--TCYGAIEKGSCARPFPGTVTKSEC--CCANPDHGFGEPCQLCPAKDSAEFQ 667
Query: 115 RSGNNSVGAIQCPDSQFECP-DFSTC----CVMVDGSWGC-CPM-----PQASCCEDRVH 163
++ +G EC D C C + GS+ C C + C D
Sbjct: 668 ALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEAGASGKDCTDVDE 727
Query: 164 CCPHGAFCDLVHTR-------CITPTGTH-----PLAKKLPAQRTNRAVALSSSVMCPDA 211
C + CD + C P G H + K + ++ V+ +
Sbjct: 728 CALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVSGVCRNLAGSY 787
Query: 212 RSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDL-IQSKCLSKEN-ATTD 269
+C GS PSG + C TC Q++ C++ +Q L E AT
Sbjct: 788 TCKCGPGSRLD--PSGTF-CLDSTKGTCWLKI-----QESRCEVNLQGASLRSECCATLG 839
Query: 270 LLTKLPAHTVGDVKCDMEVSCPDGY------TCCRLQS--GAWGCCPFTQAVCCEDHIHC 321
P +C+++ +C G+ TC + G CP + V C
Sbjct: 840 AAWGSPCE-----RCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRC 894
Query: 322 -CPAGFTCDTQKGTCEQ---GPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDT 377
CP G D C P + W E ++LP + D
Sbjct: 895 ECPEGLMLDASGRLCVDVRLEPCFLRWDEDE-CGVTLPGKYRM---------------DV 938
Query: 378 CCQLTSGEWG----CCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARR 433
CC WG CP PE++ + CP+G + + ++G
Sbjct: 939 CCCSIGAVWGVECEACPDPESL---EFASLCPRGLGFASR-------DFLSGRPFY---- 984
Query: 434 ASLSHPRDIG-CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKA 492
+D+ C TC ++G C A+ ++R C C +
Sbjct: 985 ------KDVNECKVFPGLCTHGTCRNTVGSFHCACAGGFALDAQERN--CTDIDECRISP 1036
Query: 493 RSCEKEVVSAQPATFLARSPHVGVKDVECGEGHF--------CHDNQTCCRDNR--QGWA 542
C + P +F + EC G+ C D C RD +G
Sbjct: 1037 DLCGQGTCVNTPGSF----------ECECFPGYESGFMLMKNCMDVDECARDPLLCRGGT 1086
Query: 543 CCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
C C CP G A+GT C
Sbjct: 1087 CTNTDGSYKCQ-----CPPGHELTAKGTAC 1111
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 62.4 bits (150), Expect = 1e-09
Identities = 133/558 (23%), Positives = 176/558 (31%), Gaps = 120/558 (21%)
Query: 24 QFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHL--GGPCQVDAHCSAGHSCIFTVSGTS 81
+ C + C GG Y C P PT +H G CQV A C G C
Sbjct: 1269 ELCSLQC---EGGQVYEACGPTCP--PTCHEQHPEPGWHCQVVA-CVEGCFCPEGTLLHG 1322
Query: 82 SCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCV 141
C P + C G + P G D +C C + Q+ C
Sbjct: 1323 GACLEPASCPCEWGRNSFPPGSVLQKDCGNC------------TCQEGQWHC-------- 1362
Query: 142 MVDGSWGCCPMPQASC------CEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPA-- 193
G G C +C C++ HC PHG CD + G+ P
Sbjct: 1363 --GGDGGHCEELVPACAEGEALCQENGHCVPHGWLCD---NQDDCGDGSDEEGCAAPGCG 1417
Query: 194 ---QRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQD 250
+ L +++C D + C DG+ P CP C C P
Sbjct: 1418 EGQMTCSSGHCLPLALLC-DRQDDCGDGTDEPSYP------CPQGLLACADG--RCLPPA 1468
Query: 251 TVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKC-DMEVSCPDGYTCCRLQSGAWGCCPF 309
+CD CL + + L G V C EVSC DG TC GA C
Sbjct: 1469 LLCD-GHPDCLDAADEESCL---------GQVTCVPGEVSCVDG-TCL----GAIQLC-- 1511
Query: 310 TQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNV 369
D + CP G D G C +P + PA +LP P D +
Sbjct: 1512 -------DGVWDCPDG--ADEGPGHC-----PLPSLPTPPAS-TLPGPSPGSLDTASSPL 1556
Query: 370 SSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGS-EIVAGLEK 428
+S + C E+ C C P+G+ C E C GS E G
Sbjct: 1557 ASASPAPPCGPF---EFRC----------GSGECTPRGWRCDQEEDCADGSDERGCGGPC 1603
Query: 429 MPARRASLSHPRDIG----CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPA 484
P P + CD CP G P G P+ ++ CP
Sbjct: 1604 APHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPN 1663
Query: 485 GYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACC 544
G TC C+ + +P + SP ++ CG C R C
Sbjct: 1664 G-TCIGFQLVCDGQPDCGRPGQ-VGPSP----EEQGCGAWGPWSPWGPCSR------TCG 1711
Query: 545 PYRQGVCCADRRHCCPAG 562
P+ QG R C P G
Sbjct: 1712 PWGQG----RSRRCSPLG 1725
Score = 57.4 bits (137), Expect = 4e-08
Identities = 147/655 (22%), Positives = 204/655 (31%), Gaps = 152/655 (23%)
Query: 7 WVALTAGLVAGTRCPDGQFCPVACCLDPGGASYSC-CRPLLDKWP--TTLSRHLGG-PCQ 62
W V G CP+G CL+P SC C + +P + L + G CQ
Sbjct: 1301 WHCQVVACVEGCFCPEGTLLHGGACLEPA----SCPCEWGRNSFPPGSVLQKDCGNCTCQ 1356
Query: 63 VDA-HCSA-GHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNS 120
HC G C V C EA+ C + HC P G+ C + C S
Sbjct: 1357 EGQWHCGGDGGHCEELV----PACAEGEAL-CQENGHCVPHGWLCD-NQDDCGDGSDEEG 1410
Query: 121 VGAIQCPDSQFECPD--FSTCCVMVDGSWGC----------CPMPQASCCEDRVHCCPHG 168
A C + Q C ++ D C CP +C + R C P
Sbjct: 1411 CAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGR--CLPPA 1468
Query: 169 AFCDLVHTRCITPTGTHPLAKK---LPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELP 225
CD H C+ + +P + + ++ D CPDG+ E P
Sbjct: 1469 LLCD-GHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGAD--EGP 1525
Query: 226 SGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDV--- 282
G CP+P+ P L S + A++ L + PA G
Sbjct: 1526 ----GHCPLPS----------LPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFR 1571
Query: 283 -----------KCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQ 331
+CD E C DG + G G C A C HC CD
Sbjct: 1572 CGSGECTPRGWRCDQEEDCADGSD----ERGCGGPCAPHHAPCARGP-HCVSPEQLCDGV 1626
Query: 332 K---GTCEQGPHQVPWMEK--APAHLSLPDPQ-------ALKRDVPCDNVSSC------- 372
+ ++GP + P LP P+ + + CD C
Sbjct: 1627 RQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDCGRPGQVG 1686
Query: 373 --PSSDTC-----------CQLTSGEWG------CCPIPEAVC--CSDHQHCCPQGYT-- 409
P C C T G WG C P+ V C +H +T
Sbjct: 1687 PSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPGPEHQSQACFTAA 1746
Query: 410 CVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQ- 468
C +G+ S E R +++ R H+ G+TC GG + Q
Sbjct: 1747 CPVDGEWSTWSPWSVCSEPC---RGTMTRQRQC----HSPQNGGRTCAALPGGLHSTRQT 1799
Query: 469 -------LPHAVCCEDR--QHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDV 519
P+A C + Q C P TC + +S Q D
Sbjct: 1800 KPCPQDGCPNATCSGELMFQPCAPCPLTC---------DDISGQVTC---------PPDW 1841
Query: 520 ECGE-GHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
CG G +C + Q +GW P RQ C D P G R A C+
Sbjct: 1842 PCGSPGCWCPEGQVL---GSEGWCVWP-RQCPCLVDGARYWP-GQRIKADCQLCI 1891
Score = 46.6 bits (109), Expect = 6e-05
Identities = 95/416 (22%), Positives = 124/416 (29%), Gaps = 119/416 (28%)
Query: 59 GPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHC-CPRGFHCSADGRSCFQRSG 117
GP +HCS SC + + C P GD +C PR A G C
Sbjct: 3256 GPWGPWSHCS--RSCGGGLRSRTRACDQPPPQGLGD--YCEGPR-----AQGEVC----- 3301
Query: 118 NNSVGAIQCPDSQFECPDFSTCCVMVDGS-WGCCPMPQASCCEDRVHC---------CPH 167
A+ CP T C ++G+ + C P C+D VHC CP
Sbjct: 3302 ----QALPCP---------VTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWRCQPGCYCPP 3348
Query: 168 GAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
G C+ P G L QR + P AR PDG C G
Sbjct: 3349 GQVLSSNGAICVQP-GHCSCLDLLTGQRHH-----------PGARLARPDGCNHCTCLEG 3396
Query: 228 KYGC----CPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVK 283
+ C CP+P C C Q + + S+ A P G
Sbjct: 3397 RLNCTDLPCPVPGGWCPWSEWTMCSQPC-----RGQTRSRSRACA-----CPTPQHGGAP 3446
Query: 284 CDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVP 343
C E ++GA + CP+ TC GP
Sbjct: 3447 CTGEAG----------EAGA------------QHQREACPSYATCPVDGAWGPWGPWSPC 3484
Query: 344 WMEKAPAHLSL-----PDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCS 398
M +H S P P+ R P ++ S P + Q T C
Sbjct: 3485 DMCLGQSHRSRACSRPPTPEG-GRPCPGNHTQSRPCQENSTQCTD-------------CG 3530
Query: 399 DHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQ 454
Q P G C CQ S S+ P +GC CP+GQ
Sbjct: 3531 GGQSLHPCGQPCPRS--CQDLSP------------GSVCQPGSVGCQPTCGCPLGQ 3572
Score = 41.6 bits (96), Expect = 0.002
Identities = 113/499 (22%), Positives = 148/499 (29%), Gaps = 111/499 (22%)
Query: 26 CPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCP 85
CPV C GA YS C P + L H CQ +C G +S + C
Sbjct: 3306 CPVTNCTAIEGAEYSPCGPPCPRSCDDLV-HCVWRCQPGCYCPPGQ----VLSSNGAICV 3360
Query: 86 FPEAVAC-----GDGHHCCPRGFHCSADG-RSCFQRSGNNSVGAIQCPDSQFECPDFSTC 139
P +C G HH P DG C G + + CP CP
Sbjct: 3361 QPGHCSCLDLLTGQRHH--PGARLARPDGCNHCTCLEGRLNCTDLPCPVPGGWCP----- 3413
Query: 140 CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPT--GTHPLAKKLPAQRTN 197
W C P R C C TP G + A +
Sbjct: 3414 ----WSEWTMCSQPCRGQTRSRSRAC-----------ACPTPQHGGAPCTGEAGEAGAQH 3458
Query: 198 RAVALSSSVMCPDARSRCPDG--STC--CELPSGKYGCCPMP-----NATCCSDHLHCCP 248
+ A S CP + P G S C C S + C P C +H P
Sbjct: 3459 QREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRP 3518
Query: 249 QDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGC-- 306
C TD H G C SC D Q G+ GC
Sbjct: 3519 -----------CQENSTQCTDCGGGQSLHPCGQ-PCPR--SCQDLSPGSVCQPGSVGCQP 3564
Query: 307 ---CPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRD 363
CP Q +D + PA C Q G +P + A ++L+
Sbjct: 3565 TCGCPLGQ--LSQDGLCVPPAHCRCQYQPGAM-----GIPENQSRSAGSRFSSWESLEPG 3617
Query: 364 V----PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRG 419
PCDN C +G C +P+ CP + G +
Sbjct: 3618 EVVTGPCDN----------CTCVAGILQCQEVPD----------CPDPGVWSSWGPWEDC 3657
Query: 420 SEIVAGLEKMPARR---------ASLSHPRDIGCDQHTSCPVG---QTCCPSLGGSWACC 467
S G E++ +RR A S + CP G + C P G ++C
Sbjct: 3658 SVSCGGGEQLRSRRCARPPCPGPARQSRTCSTQVCREAGCPAGRLYRECQPGEGCPFSCA 3717
Query: 468 QLPHAV-C----CEDRQHC 481
+ V C CE+ HC
Sbjct: 3718 HVTQQVGCFSEGCEEGCHC 3736
Score = 38.1 bits (87), Expect = 0.023
Identities = 117/515 (22%), Positives = 151/515 (29%), Gaps = 137/515 (26%)
Query: 11 TAGLVAGTRCPDGQFCPVACCLDPGGASYSCCRPLLD----KW-------------PTTL 53
TA L CPD CP +C G C P +W P
Sbjct: 4597 TAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPWAQ 4656
Query: 54 SRHLGGPCQVDAHCSAGHSCIFTVSGTS----SCCPFPEAVACGDGHHCCPRGFHCS--- 106
GGPC C A +FT+ + SC + V C G C G C
Sbjct: 4657 ESCNGGPC---PECEA-QDTVFTLDCANQCPHSCADLWDRVQCLQGP--CRPGCRCPPGQ 4710
Query: 107 --ADGR-------SCFQRSGNNS-----VGAIQ-------CPDSQFECPDFSTCCVMVDG 145
DGR C S N S A+Q C + CP +
Sbjct: 4711 LVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCPHQECPVLGPWS 4770
Query: 146 SWGCCPMPQASCCEDRVHCCPHG---AFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVAL 202
+W C P +R C G A C T P + P Q V
Sbjct: 4771 AWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPECPPGQ-----VLS 4825
Query: 203 SSSVMCPDARSRCPDGSTCCELPSGKYGC-CP----MPNATCCSDHLHCCPQDTVCDLIQ 257
+ + CP G+ C + P + GC CP + N TC C Q + L
Sbjct: 4826 ACATSCPCLCWHLQPGAICVQEPC-QPGCGCPGGQLLHNGTCVPPTACPCTQHS---LPW 4881
Query: 258 SKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCED 317
L+ E + LP TV C T C GA+ C V C+
Sbjct: 4882 GLTLTLEEQAQE----LPPGTVLTRNC----------TRCVCHGGAFSC----SLVDCQ- 4922
Query: 318 HIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDT 377
P G T W + AP L L + L+ +
Sbjct: 4923 ----VPPGET----------------WQQVAPGELGLCEQTCLEMNA------------- 4949
Query: 378 CCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ---RGSEIVAGLEKMPARRA 434
T + C + C H Q CV E C+ G + G E A +
Sbjct: 4950 ----TKTQSNCSSARASGCVCQPGHFRSQAGPCVPEDHCECWHLGRPHLPGSEWQEACES 5005
Query: 435 SLSHPRDIGCDQHTS---CPVGQ-------TCCPS 459
L C QH S C G+ +CCPS
Sbjct: 5006 CLCLSGRPVCTQHCSPLTCAQGEEMVLEPGSCCPS 5040
Score = 34.7 bits (78), Expect = 0.25
Identities = 51/228 (22%), Positives = 75/228 (32%), Gaps = 37/228 (16%)
Query: 364 VPCDNVSSCPSSD---TCCQLTSGEWGCCPIPEAVCCSDHQHC-----CPQGYT-----C 410
+PC+ + CP+ TC C + E + C D Q C CP+G C
Sbjct: 4056 MPCE--AGCPAGMEVVTCANRCPRR--CSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGC 4111
Query: 411 VAEGQCQ----RGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWAC 466
V G C +G G + A + C CP C S +W+
Sbjct: 4112 VPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQ-PCPPPTHCAWSHWSAWSP 4170
Query: 467 CQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHV--GVKDVECGEG 524
C H+ C Q T A C +E +QP + P G + G+
Sbjct: 4171 CS--HS-CGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRSRTLGDS 4227
Query: 525 HFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
+ Q C +C P +GV C D P + + + C
Sbjct: 4228 WLQGECQRC--------SCTP--EGVICEDTECAVPEAWTLWSSWSDC 4265
Score = 33.9 bits (76), Expect = 0.43
Identities = 77/351 (21%), Positives = 110/351 (31%), Gaps = 73/351 (20%)
Query: 280 GDVKCDMEVSCPDG--YTC---CRLQSGAW----GCCPFTQAVCC-EDHIH--------- 320
G C E+S P G TC C SG C P C E H++
Sbjct: 3102 GPASC-AELSAPRGTNQTCHPGCHCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRP 3160
Query: 321 ----CCPAGFTCDTQKGTCEQG-PHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSS 375
C +G + C +G P PW + S + + + S+ PS+
Sbjct: 3161 CENCSCVSGLIANCSSWPCAEGEPTWSPWTPWSQCSASCGPARCHRHRFCARSPSAVPST 3220
Query: 376 DTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAE----GQCQRGSEIVAGLEKMPA 431
L + C PEA + + C QG G S G +
Sbjct: 3221 VAPLPLPATPTPLCSGPEA----EEEPCLLQGCDRAGGWGPWGPWSHCSRSCGGGLRSRT 3276
Query: 432 RRASLSHPRDIG--CD---------QHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQH 480
R P+ +G C+ Q CPV C G ++ C P C+D H
Sbjct: 3277 RACDQPPPQGLGDYCEGPRAQGEVCQALPCPV-TNCTAIEGAEYSPCGPPCPRSCDDLVH 3335
Query: 481 C---------CPAGYTCNVKARSCEK-------EVVSAQ---PATFLARSPHVGVKDVEC 521
C CP G + C + ++++ Q P LAR G C
Sbjct: 3336 CVWRCQPGCYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPD--GCNHCTC 3393
Query: 522 GEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
EG + C GW CP+ + C+ C R +R C
Sbjct: 3394 LEGRLNCTDLPCPVPG--GW--CPWSEWTMCSQP---CRGQTRSRSRACAC 3437
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 61.6 bits (148), Expect = 2e-09
Identities = 106/500 (21%), Positives = 164/500 (32%), Gaps = 95/500 (19%)
Query: 93 GDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPM 152
G H C GF DGR+C A Q P + E ++ + + P+
Sbjct: 625 GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPL-------PL 677
Query: 153 PQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDAR 212
PQ + C+D C + + G + P ++ V C D +
Sbjct: 678 PQPNTCKDNGPC-----------KQVCSTVGGSAICSCFPGY-----AIMADGVSCED-Q 720
Query: 213 SRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLT 272
C G+ C S + C + C +H C + + KC+ TDL T
Sbjct: 721 DECLMGAHDC---SRRQFCVNTLGSFYCVNHTVLCADGYILNA-HRKCVDINECVTDLHT 776
Query: 273 ----KLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTC 328
+ +T+G C ++C GY L+ G C C H C GF C
Sbjct: 777 CSRGEHCVNTLGSFHCYKALTCEPGYA---LKDGE---CEDVDE--CAMGTHTCQPGFLC 828
Query: 329 DTQKGT--CEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPS-SDTC-----CQ 380
KG+ C+ + L DP+ C +++ C S S+ C C
Sbjct: 829 QNTKGSFYCQARQRCMDGF--------LQDPEG-----NCVDINECTSLSEPCRPGFSCI 875
Query: 381 LTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRG------SEIVAGLEKMPARRA 434
T G + C P + C+ H G CV +C+ G ++ L
Sbjct: 876 NTVGSYTCQRNP--LICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933
Query: 435 SLSHPRDI---GCDQHTSC--PVGQTC---CPSLGGSWACCQLPHAVCCEDRQHCCPAGY 486
RD GC C G+ C C + GS+ C + D + C
Sbjct: 934 KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC----- 988
Query: 487 TCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPY 546
CE + S + A G C +G+ ++ C D + C
Sbjct: 989 ---EDVNECEAQRCSQECANI------YGSYQCYCRQGYQLAEDGHTCTDIDE----CAQ 1035
Query: 547 RQGVCCADRRHCCPAGFRCA 566
G+ C R P ++CA
Sbjct: 1036 GAGILCTFRCLNVPGSYQCA 1055
Score = 60.1 bits (144), Expect = 6e-09
Identities = 108/476 (22%), Positives = 149/476 (31%), Gaps = 110/476 (23%)
Query: 140 CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRA 199
C+ GS+ C P S +D C P G P A + PA ++ +
Sbjct: 620 CINTVGSYHCACFPGFSLQDDGRTCRPEG-------------HPPQPEAPQEPALKSEFS 666
Query: 200 VALSSSVMCP-DARSRCPDGSTC---CELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDL 255
S+++ P + C D C C G C P +D + C QD C +
Sbjct: 667 QVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDE-CLM 725
Query: 256 IQSKCLSKENATTDLLTKLPAHTVGDVKC-DMEVSCPDGYTCCRLQSGAWGCCPFTQAVC 314
C ++ +T+G C + V C DGY
Sbjct: 726 GAHDCSRRQ---------FCVNTLGSFYCVNHTVLCADGY-------------------I 757
Query: 315 CEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLP-DPQALKRDVPCDNVSSCP 373
H C C T TC +G H V + + +L +P +D C++V C
Sbjct: 758 LNAHRKCVDIN-ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECA 816
Query: 374 -SSDTC-----CQLTSGEWGC----------CPIPEAVC-----CSDHQHCCPQGYTC-- 410
+ TC CQ T G + C PE C C+ C G++C
Sbjct: 817 MGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCIN 876
Query: 411 -VAEGQCQRGSEIVAGLEKMPARRASLSHPRDIG--CDQHTSCPVGQTCCPSLGGSWACC 467
V CQR P A H D G C C G C G C
Sbjct: 877 TVGSYTCQRN----------PLICARGYHASDDGTKCVDVNECETGVHRC---GEGQVCH 923
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSC-EKEVVSAQPATFLARSPHVGVKDVEC----- 521
LP + C+ C AG+ + R C + A P + + C
Sbjct: 924 NLPGSYRCD-----CKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASG 978
Query: 522 ----GEGHFCHDNQTC----CRD---NRQGWACCPYRQGVCCADRRHCCPAGFRCA 566
+G C D C C N G C RQG A+ H C CA
Sbjct: 979 FLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECA 1034
Score = 45.8 bits (107), Expect = 1e-04
Identities = 84/371 (22%), Positives = 111/371 (29%), Gaps = 128/371 (34%)
Query: 320 HC-CPAGFTCDTQKGTCEQGPHQVPWMEKAPAH----------------LSLPDPQALKR 362
HC C GF+ TC H P +AP L LP P K
Sbjct: 628 HCACFPGFSLQDDGRTCRPEGH--PPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD 685
Query: 363 DVPCDNVS----------------------SCPSSDTC------------CQLTSGEWGC 388
+ PC V SC D C C T G + C
Sbjct: 686 NGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDQDECLMGAHDCSRRQFCVNTLGSFYC 745
Query: 389 CPIPEAVCCSD------HQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHP--- 439
+ V C+D H+ C C RG V L +A P
Sbjct: 746 --VNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYA 803
Query: 440 -RDIGCDQHTSCPVG-QTC-----CPSLGGSWAC----------CQLPHAVC-----CED 477
+D C+ C +G TC C + GS+ C Q P C C
Sbjct: 804 LKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTS 863
Query: 478 RQHCCPAGYTC--NVKARSCEKEVVSAQPATFLARSPHV---GVKDVE----------CG 522
C G++C V + +C++ + AR H G K V+ CG
Sbjct: 864 LSEPCRPGFSCINTVGSYTCQRNPL------ICARGYHASDDGTKCVDVNECETGVHRCG 917
Query: 523 EGHFCHD---NQTC--------------CRDNRQGWA----CCPYRQGVCCADRRHCCPA 561
EG CH+ + C C D + WA C + R C +
Sbjct: 918 EGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCAS 977
Query: 562 GFRCAARGTKC 572
GF AA G +C
Sbjct: 978 GFLLAADGKRC 988
Score = 36.6 bits (83), Expect = 0.067
Identities = 66/296 (22%), Positives = 89/296 (30%), Gaps = 78/296 (26%)
Query: 67 CSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSC---------FQRSG 117
C G SCI TV + C C RG+H S DG C R G
Sbjct: 868 CRPGFSCINTVG----------SYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCG 917
Query: 118 NNSV-----GAIQCP-DSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRV---HC-CPH 167
V G+ +C + F+ F C+ V+ W CE+ + C C
Sbjct: 918 EGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCAS 977
Query: 168 GAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVAL---SSSVMCPDARSRCPDGSTCCEL 224
G RC + AQR ++ A S C DG TC ++
Sbjct: 978 GFLLAADGKRCED-------VNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDI 1030
Query: 225 PS-----------------GKYGC-CPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENA 266
G Y C CP T ++ C D C L C E
Sbjct: 1031 DECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDE-CALGTHNCSEAET- 1088
Query: 267 TTDLLTKLPAHTV-GDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC 321
H + G +C + CP Y +Q C + C D + C
Sbjct: 1089 ---------CHNIQGSFRC-LRFECPPNY----VQVSKTKC----ERTTCHDFLEC 1126
Score = 34.3 bits (77), Expect = 0.33
Identities = 30/129 (23%), Positives = 48/129 (37%), Gaps = 46/129 (35%)
Query: 454 QTCCPSLGGSWA-----CCQLPHA-----VCCEDRQHCCPAGYTCNVKARSCEKEVVSAQ 503
+TCC + G WA C ++P + VC ++HCC + ++ +SC V+ A+
Sbjct: 443 ETCCAA-GQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVS----YLQEKSCMAGVLGAK 497
Query: 504 PATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGF 563
+ +TC ++ Y+Q CC CC G
Sbjct: 498 -------------------------EGETCGAEDNDSCGISLYKQ--CC----DCCGLGL 526
Query: 564 RCAARGTKC 572
R A G C
Sbjct: 527 RVRAEGQSC 535
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 61.2 bits (147), Expect = 3e-09
Identities = 106/443 (23%), Positives = 144/443 (32%), Gaps = 112/443 (25%)
Query: 29 ACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCP--F 86
AC PG + + C + P + G CQ+ C G C +++G +C P
Sbjct: 378 ACTCQPGWSGHHCN----ESCPVG---YYGDGCQLPCTCQNGADC-HSITGGCTCAPGFM 429
Query: 87 PE--AVACGDGHH--------CCPRGFHCSADGRSCFQRSGNNSVGA-IQCPDSQF--EC 133
E AV+C G + C G CS SC + G + + CP + C
Sbjct: 430 GEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNC 489
Query: 134 PDFSTC-----CVMVDGSWGCCPMPQASCCEDRVHCCPHGAF-------CDLVHTRCITP 181
+ TC C +DGS C P CE CP G F CD H P
Sbjct: 490 NESCTCANGAACSPIDGSCSCTPGWLGDTCELP---CPDGTFGLNCSEHCDCSHADGCDP 546
Query: 182 TGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATC-C 240
H +A + + C STC P G++G P + +C C
Sbjct: 547 VTGHCCC-----------LAGWTGIRCD---------STC---PPGRWG--PNCSVSCSC 581
Query: 241 SDHLHCCPQDTVCD--------LIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPD 292
+ C P+D C+ L Q C P G C
Sbjct: 582 ENGGSCSPEDGSCECAPGFRGPLCQRIC--------------PPGFYGHGCAQPCPLCVH 627
Query: 293 GYTCCRLQSGAWGCCP-FTQAVC------------CEDHIHCCPAGFTCDTQKGTCEQGP 339
C SG C P F+ A+C C C G TC G+C+ P
Sbjct: 628 SSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNG-TCSPIDGSCQCFP 686
Query: 340 HQVPWMEKAPAHLSLPD--PQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCC 397
W+ K + P A C N +SC + D C T G G + C
Sbjct: 687 G---WIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTG-------LFC 736
Query: 398 SDHQHCCPQGYTCVAEGQCQRGS 420
+ G C QCQ G+
Sbjct: 737 TQRCPAAFFGKDCGRVCQCQNGA 759
Score = 58.9 bits (141), Expect = 1e-08
Identities = 127/524 (24%), Positives = 165/524 (31%), Gaps = 115/524 (21%)
Query: 84 CPFPEAVAC--GDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCV 141
C P+ C G G C G G C R QC + C + CV
Sbjct: 112 CVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRC--------QCQNGAL-CNPITGACV 162
Query: 142 MVDGSWG------CCPMPQASCCEDRVHC-CPHGAFCDLVHTRCITPTG-THPLAKKLPA 193
G G C P C+ + C C HGA CD C+ G T ++L
Sbjct: 163 CAAGFRGWRCEELCAPGTHGKGCQ--LPCQCRHGASCDPRAGECLCAPGYTGVYCEELCP 220
Query: 194 QRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVC 253
++ A + CP C +G TC + +G+ C P C+ CP T
Sbjct: 221 PGSHGA---HCELRCP-----CQNGGTCHHI-TGECACPPGWTGAVCAQP---CPPGTFG 268
Query: 254 DLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPF-TQA 312
C D H G + C GY R Q CPF +
Sbjct: 269 QNCSQDCPCHHGGQCD-------HVTG------QCHCTAGYMGDRCQEE----CPFGSFG 311
Query: 313 VCCEDHIHCCPAGFTCDTQKGTCEQGP-HQVPWMEKAPAHLSLPDPQALKRDVPCDNVSS 371
C H C G C G CE P ++ P ++ L P +PC
Sbjct: 312 FQCSQHCDCHNGG-QCSPTTGACECEPGYKGPRCQERLCPEGLHGPGC---TLPC----P 363
Query: 372 CPSSDT-CCQLTSGEWGCCPIPEAVCCSDHQHCCPQGY---TCVAEGQCQRGSE---IVA 424
C + +T C +G C P C++ CP GY C CQ G++ I
Sbjct: 364 CDADNTISCHPVTGACTCQPGWSGHHCNE---SCPVGYYGDGCQLPCTCQNGADCHSITG 420
Query: 425 GLEKMPARRASL------SHPRDIGCDQHTSCPVGQTCCPSLGGSWAC--------CQLP 470
G P + + C SC G TC P + GS C C LP
Sbjct: 421 GCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSP-VDGSCTCKEGWQGLDCTLP 479
Query: 471 HAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDN 530
CP+G +C + A A A SP G C G
Sbjct: 480 -----------CPSG----TWGLNCNESCTCANGA---ACSPIDG--SCSCTPGWLGDTC 519
Query: 531 QTCCRDNRQGWAC-----CPYRQGVCCADRRHCCP----AGFRC 565
+ C D G C C + G C HCC G RC
Sbjct: 520 ELPCPDGTFGLNCSEHCDCSHADG-CDPVTGHCCCLAGWTGIRC 562
Score = 40.8 bits (94), Expect = 0.004
Identities = 82/354 (23%), Positives = 100/354 (28%), Gaps = 95/354 (26%)
Query: 20 CPDGQF---CPVAC-CLDPGGAS----YSCCRPLLDKWP------TTLSRHLGGPCQVDA 65
CPDG F C C C G + CC L W T G C V
Sbjct: 523 CPDGTFGLNCSEHCDCSHADGCDPVTGHCCC---LAGWTGIRCDSTCPPGRWGPNCSVSC 579
Query: 66 HCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQ 125
C G SC G+ C P C CP GF+ G C Q
Sbjct: 580 SCENGGSCS-PEDGSCECAPGFRGPLC---QRICPPGFY----GHGCAQ----------P 621
Query: 126 CPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTH 185
CP C S C + G C P + C C G F
Sbjct: 622 CP----LCVHSSRPCHHISGICECLPGFSGALCNQ---VCAGGYF-------------GQ 661
Query: 186 PLAKKLPAQRTNRAVALSSSVMC------PDARSRCPDGSTCCELPSGKYGCCPMPNATC 239
A+ + S C D CP G P+ + C A+C
Sbjct: 662 DCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWG---PACFHACSCHNGASC 718
Query: 240 CSDH--LHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC- 296
++ HC P T Q + PA G C C +G +C
Sbjct: 719 SAEDGACHCTPGWTGLFCTQ---------------RCPAAFFGK-DCGRVCQCQNGASCD 762
Query: 297 -----CRLQSGAWG------CCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGP 339
C ++G G C P T C+ C TCD GTC P
Sbjct: 763 HISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNS-TCDHVTGTCYCSP 815
Score = 35.8 bits (81), Expect = 0.11
Identities = 57/225 (25%), Positives = 76/225 (33%), Gaps = 64/225 (28%)
Query: 13 GLVAGTRCPDGQF---CPVACCLDPGGA------SYSCCR----PLLDKW--PTTLSRHL 57
G+ + CP G++ C V+C + GG+ S C PL + P
Sbjct: 559 GIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGC 618
Query: 58 GGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQ--R 115
PC + H S C +SG C P C + C G+ G+ C Q
Sbjct: 619 AQPCPLCVHSS--RPC-HHISGICECLPGFSGALC---NQVCAGGYF----GQDCAQLCS 668
Query: 116 SGNNSV-----GAIQC------PDSQFECPD-------FSTC-------CVMVDGSWGCC 150
NN G+ QC D CP F C C DG+ C
Sbjct: 669 CANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCT 728
Query: 151 P----------MPQASCCED--RVHCCPHGAFCDLVHTRCITPTG 183
P P A +D RV C +GA CD + +C TG
Sbjct: 729 PGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTG 773
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 60.8 bits (146), Expect = 3e-09
Identities = 131/540 (24%), Positives = 169/540 (31%), Gaps = 131/540 (24%)
Query: 81 SSCCP-FPE---------AVACGDGHHCCPRGFHCSAD--GRSCFQRSGNNSVGAIQCPD 128
S CCP F E A C G P C G +C + G C
Sbjct: 92 SQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGP-HCT- 149
Query: 129 SQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVH-----------C-CPHGAFCDLVHT 176
S+ +C + C + G+ C + CEDR C C +GA CD V
Sbjct: 150 SRCQCKN-GALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHVTG 208
Query: 177 RCITPTG-THPLAKKL--PAQRTNRAVALSSSVMCPDARSRCP--DGSTC------CELP 225
C P G T + L P + P RCP +G C C P
Sbjct: 209 ECRCPPGYTGAFCEDLCPPGKHG------------PQCEQRCPCQNGGVCHHVTGECSCP 256
Query: 226 SGKYG-CCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKC 284
SG G C P CP+ +C T D T
Sbjct: 257 SGWMGTVCGQP-----------CPEGRFGKNCSQECQCHNGGTCDAATG----------- 294
Query: 285 DMEVSCPDGYTCCRLQSGAWGCCPF-TQAVCCEDHIHCCPAGFTCDTQKGT--CEQGPHQ 341
+ C GYT R Q CP T V C + C G C G CE G
Sbjct: 295 --QCHCSPGYTGERCQDE----CPVGTYGVLCAETCQCVNGG-KCYHVSGACLCEAGFAG 347
Query: 342 VPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDT-CCQLTSGEWGCCPIPEAVCCSDH 400
E+ A L P+ L + CD C +T C SGE C P + C +
Sbjct: 348 ----ERCEARLC---PEGL-YGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYC--N 397
Query: 401 QHCCP--QGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVG----- 453
+ C P G C CQ G++ + K P G D T CP+G
Sbjct: 398 ETCSPGFYGEACQQICSCQNGADCDSVTGKCTCA------PGFKGIDCSTPCPLGTYGIN 451
Query: 454 ---------QTCCPSLGGSWACCQLPHAVCCEDRQHCCPA---GYTCNVKARSCEKEVVS 501
C + GS C H V C R CP+ G+ CN+ + +
Sbjct: 452 CSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIR---CPSGTWGFGCNLTCQCLNGGACN 508
Query: 502 AQPATFLARSPHVGVK-DVECGEGHF---CHDNQTC-----CRDNRQGWACCPYRQGVCC 552
T G K ++ C +G + C + C C C P GV C
Sbjct: 509 TLDGTCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHC 568
Score = 59.3 bits (142), Expect = 1e-08
Identities = 153/616 (24%), Positives = 193/616 (31%), Gaps = 191/616 (31%)
Query: 13 GLVAGTRCPDGQF---CPVACCLDPGG----ASYSC-CRP------LLDKWPTTLSRHLG 58
G V G CP+G+F C C GG A+ C C P D+ P G
Sbjct: 261 GTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGT---YG 317
Query: 59 GPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHC--CPRGFHCSADGRSCFQRS 116
C C G C + VSG C EA G+ CP G + G C +R
Sbjct: 318 VLCAETCQCVNGGKC-YHVSGACLC----EAGFAGERCEARLCPEGLY----GIKCDKR- 367
Query: 117 GNNSVGAIQCP---DSQFECPDFSTCCVMVDGSWG------CCPMPQASCCEDRVHCCPH 167
CP ++ C S C G G C P C+ ++ C +
Sbjct: 368 ---------CPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQ-QICSCQN 417
Query: 168 GAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCP-DARSRCPDGSTCCE--- 223
GA CD V +C G + P + SS C DA DGS C+
Sbjct: 418 GADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGW 477
Query: 224 --------LPSGK--YGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTK 273
PSG +GC N TC C C+ + C +
Sbjct: 478 HGVDCSIRCPSGTWGFGC----NLTC------QCLNGGACNTLDGTCTCAPGWRGE---- 523
Query: 274 LPAHTVGDVKCDMEVSCPD---GYTCCRL--QSGAWGCCPFTQAVCCEDHIHCCP--AGF 326
KC E+ C D G C S A GC P T H C P +G
Sbjct: 524 ---------KC--ELPCQDGTYGLNCAERCDCSHADGCHPTT------GHCRCLPGWSGV 566
Query: 327 TCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEW 386
CD+ GP + SLP C N +SC D C+ G
Sbjct: 567 HCDSVCAEGRWGP-----------NCSLP--------CYCKNGASCSPDDGICECAPGFR 607
Query: 387 G------CCPIPEAVCCSDHQHCCPQGYTCV-AEGQCQRGSEIVAGLEKMPARRASLSHP 439
G C P CS CPQ CV + G C + GL
Sbjct: 608 GTTCQRICSPGFYGHRCS---QTCPQ---CVHSSGPCHH----ITGL------------- 644
Query: 440 RDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDR--QHC-----CPAGYTCNVKA 492
CD C P G+ L + VC R ++C C TCN
Sbjct: 645 ----CD----------CLPGFTGA-----LCNEVCPSGRFGKNCAGICTCTNNGTCNPID 685
Query: 493 RSCE-----KEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYR 547
RSC+ +QP P+ + C G FC C+ C P
Sbjct: 686 RSCQCYPGWIGSDCSQPCPPAHWGPNC-IHTCNCHNGAFCSAYDGECK-------CTPGW 737
Query: 548 QGVCCADRRHCCPAGF 563
G+ C R CP GF
Sbjct: 738 TGLYCTQR---CPLGF 750
Score = 55.5 bits (132), Expect = 1e-07
Identities = 106/438 (24%), Positives = 147/438 (33%), Gaps = 102/438 (23%)
Query: 30 CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEA 89
C PG + C T G CQ C G C +V+G +C P +
Sbjct: 385 CACKPGWSGLYCNE-------TCSPGFYGEACQQICSCQNGADCD-SVTGKCTCAPGFKG 436
Query: 90 VACGD-------GHHC-----CPRGFHCSADGRSCFQRSGNNSVG-AIQCPDSQFECPDF 136
+ C G +C C CS SC ++G + V +I+CP +
Sbjct: 437 IDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCN 496
Query: 137 STC-------CVMVDGSWGCCPMPQASCCEDRVHCCPHGAF-------CDLVHTRCITPT 182
TC C +DG+ C P + CE C G + CD H PT
Sbjct: 497 LTCQCLNGGACNTLDGTCTCAPGWRGEKCELP---CQDGTYGLNCAERCDCSHADGCHPT 553
Query: 183 GTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC-CPMPNATCCS 241
H + LP S V C S C E G++G C +P C
Sbjct: 554 TGH--CRCLPGW---------SGVHCD---------SVCAE---GRWGPNCSLP--CYCK 588
Query: 242 DHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEV-SCPDGYTCCRLQ 300
+ C P D +C+ C TT ++ + +C C C
Sbjct: 589 NGASCSPDDGICE-----CAPGFRGTT--CQRICSPGFYGHRCSQTCPQCVHSSGPCHHI 641
Query: 301 SGAWGCCP-FTQAVCCEDHIHCCPAG---------FTCDTQKGTCEQGPHQVP----WME 346
+G C P FT A+C E CP+G TC T GTC W+
Sbjct: 642 TGLCDCLPGFTGALCNE----VCPSGRFGKNCAGICTC-TNNGTCNPIDRSCQCYPGWIG 696
Query: 347 KAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQ 406
+ S P P A C + +C + C GE C P + C+ CP
Sbjct: 697 ---SDCSQPCPPA-HWGPNCIHTCNCHNG-AFCSAYDGECKCTPGWTGLYCTQR---CPL 748
Query: 407 GY---TCVAEGQCQRGSE 421
G+ C QCQ G++
Sbjct: 749 GFYGKDCALICQCQNGAD 766
Score = 33.1 bits (74), Expect = 0.74
Identities = 58/252 (23%), Positives = 78/252 (30%), Gaps = 64/252 (25%)
Query: 56 HLGGPCQVDAHCSAGHSCI--FTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCF 113
H GPC H + C+ FT + + CP G C C+ RSC
Sbjct: 633 HSSGPCH---HITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQ 689
Query: 114 QRSGNNSVGAIQ-CPDSQFECPDFSTC-------CVMVDGSWGCCPMPQASCCEDR---- 161
G Q CP + + TC C DG C P C R
Sbjct: 690 CYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLG 749
Query: 162 --------VHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARS 213
+ C +GA CD + +C TG M
Sbjct: 750 FYGKDCALICQCQNGADCDHISGQCTCRTG----------------------FMGRHCEQ 787
Query: 214 RCPDGSTCCELPSGKYGC---CPMPNATCCSDHL----HCCP--QDTVCDLIQSKCLSKE 264
+CP G+ YGC C N + C DH+ +C P + CD +
Sbjct: 788 KCPSGTY-------GYGCRQICDCLNNSTC-DHITGTCYCSPGWKGARCDQAGVIIVGNL 839
Query: 265 NATTDLLTKLPA 276
N+ + T LPA
Sbjct: 840 NSLSRTSTALPA 851
>gi|148727298 keratin associated protein 10-6 [Homo sapiens]
Length = 365
Score = 60.5 bits (145), Expect = 4e-09
Identities = 79/316 (25%), Positives = 109/316 (34%), Gaps = 61/316 (19%)
Query: 204 SSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCC---SDHLHCCPQDTVCDLIQSKC 260
S V P +R P CE + GC +CC S L CC Q C
Sbjct: 54 SLVCTPVSRVSSPCCPVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCASSPC----QQAC 109
Query: 261 LSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFT--QAVCCEDH 318
T + C + V C D +CC+ S CC + Q CC
Sbjct: 110 CVPVCCKTVCCKPV---------CCVSVCCGDS-SCCQQSSCQSACCTSSPCQQACCVPV 159
Query: 319 IHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC 378
CC C +C Q + +S P QA+ PC + + + +C
Sbjct: 160 --CCKP--VCSGISSSCCQ-------QSSCVSCVSSPCCQAVCEPSPCQSGCTSSCTPSC 208
Query: 379 CQLTSGEWGCC---PIPEAVC---CSDHQHCCPQGYTCVAEGQ--CQRGSEIVAGLEKMP 430
CQ +S + CC P +A C C C P TC + CQ+ S A P
Sbjct: 209 CQQSSCQPTCCTSSPCQQACCVPVCCVPVCCVP---TCSEDSSSCCQQSSCQPACCTSSP 265
Query: 431 ARRA---SLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQ-------LPHAVCCEDRQH 480
+ A + C Q +SC CC + +CC+ L H VC +
Sbjct: 266 CQHACCVPVCSGASTSCCQQSSCQ--PACCTA-----SCCRPSSSVSLLCHPVC---KST 315
Query: 481 CCPAGYTCNVKARSCE 496
CC +C A SC+
Sbjct: 316 CCVPVPSCGASASSCQ 331
Score = 52.0 bits (123), Expect = 2e-06
Identities = 71/292 (24%), Positives = 94/292 (32%), Gaps = 91/292 (31%)
Query: 306 CCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK---- 361
CCP T CE C +G T C+Q Q+ +P + P K
Sbjct: 67 CCPVT----CEPSP--CQSGCTSSCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCC 120
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWGCC---PIPEA----VCCSD-----HQHCCPQG-- 407
+ V C VS C +CCQ +S + CC P +A VCC CC Q
Sbjct: 121 KPVCC--VSVCCGDSSCCQQSSCQSACCTSSPCQQACCVPVCCKPVCSGISSSCCQQSSC 178
Query: 408 YTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACC 467
+CV+ CQ A E P + S C Q + P TCC S ACC
Sbjct: 179 VSCVSSPCCQ------AVCEPSPCQSGCTSSCTPSCCQQSSCQP---TCCTSSPCQQACC 229
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC 527
VCC CC TC+
Sbjct: 230 V---PVCCVPV--CCVP--TCS-------------------------------------- 244
Query: 528 HDNQTCCRDNRQGWACCPYR--QGVCCADRRHCCPAGFRCAARGTKCLRREA 577
D+ +CC+ + ACC Q CC C+ T C ++ +
Sbjct: 245 EDSSSCCQQSSCQPACCTSSPCQHACCVP---------VCSGASTSCCQQSS 287
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/309 (22%), Positives = 98/309 (31%), Gaps = 52/309 (16%)
Query: 26 CPVACCLDP--GGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSC 83
CPV C P G + SC + L+ PCQ A C C TV C
Sbjct: 68 CPVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCASSPCQ-QACCVP--VCCKTVCCKPVC 124
Query: 84 CPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMV 143
C +V CGD SC Q+S S P Q CCV V
Sbjct: 125 CV---SVCCGDS---------------SCCQQSSCQSACCTSSPCQQ-------ACCVPV 159
Query: 144 DGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALS 203
CC + C CC + V + C + + P Q +
Sbjct: 160 -----CC---KPVCSGISSSCCQQSSCVSCVSSPCC-----QAVCEPSPCQSGCTSSCTP 206
Query: 204 SSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSK 263
S + C S C + C P+ CS+ C Q + C Q C +
Sbjct: 207 SCCQQSSCQPTCCTSSPCQQACCVPVCCVPVCCVPTCSEDSSSCCQQSSC---QPACCT- 262
Query: 264 ENATTDLLTKLPAHTVGDVKCDMEVSCPDG---YTCCRLQSG-AWGCCPFTQAVCCEDHI 319
++ +P + C + SC +CCR S + C P ++ CC
Sbjct: 263 -SSPCQHACCVPVCSGASTSCCQQSSCQPACCTASCCRPSSSVSLLCHPVCKSTCCVPVP 321
Query: 320 HCCPAGFTC 328
C + +C
Sbjct: 322 SCGASASSC 330
Score = 42.7 bits (99), Expect = 0.001
Identities = 65/228 (28%), Positives = 76/228 (33%), Gaps = 32/228 (14%)
Query: 18 TRCPDGQFCPVACCLDP--GGASYSCCRP----LLDKWPTTLSRHLGGPCQVDAHCSAGH 71
T P Q C V C P G S SCC+ P + PCQ S
Sbjct: 147 TSSPCQQACCVPVCCKPVCSGISSSCCQQSSCVSCVSSPCCQAVCEPSPCQSGCTSSCTP 206
Query: 72 SCIFTVSGTSSCC-PFPEAVACGDGHHCCPRGF--HCSADGRSCFQRSGNNSVGAIQCPD 128
SC S +CC P AC C P CS D SC Q+S S C
Sbjct: 207 SCCQQSSCQPTCCTSSPCQQACCVPVCCVPVCCVPTCSEDSSSCCQQS---SCQPACCTS 263
Query: 129 SQFECPDFSTCCVMV--DGSWGCCPMP--QASCCEDRVHCC-PHGAFCDLVHTRC----- 178
S P CCV V S CC Q +CC CC P + L H C
Sbjct: 264 S----PCQHACCVPVCSGASTSCCQQSSCQPACC--TASCCRPSSSVSLLCHPVCKSTCC 317
Query: 179 --ITPTGTHPLAKKLPAQRTNRAVALSSSVMC--PDARSRCPDGSTCC 222
+ G + + RT V+L MC P S C + C
Sbjct: 318 VPVPSCGASASSCQPSCCRTASCVSLLCRPMCSRPACYSLCSGQKSSC 365
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 58.5 bits (140), Expect = 2e-08
Identities = 146/594 (24%), Positives = 191/594 (32%), Gaps = 138/594 (23%)
Query: 17 GTRCPDGQFC--------PVACCLDPGGASYSC-CRPLLDKWPTTLSRHLGGPC-QVDAH 66
GTRC D C P C PG S+ C C P P C +V
Sbjct: 515 GTRCIDVDECRRVPPPCAPGRCENSPG--SFRCVCGPGFRAGPRAAECLDVDECHRVPPP 572
Query: 67 CSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQC 126
C G C P + C CP G+ + G SC +C
Sbjct: 573 CDLGR-----------CENTPGSFLC-----VCPAGYQAAPHGASC--------QDVDEC 608
Query: 127 PDSQFECPDFSTCCVMVDGSWGC-CPMP-QASCCEDRV-HCCPHGAFCDLVHTRCITPTG 183
S C C + GS+ C CP + S CE+ V C C RC G
Sbjct: 609 TQSPGLCG--RGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG--PGRCDNTAG 664
Query: 184 THPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC-CPM---PN--- 236
+ A PA +R + ARS P CE G + C CPM PN
Sbjct: 665 SFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAG 722
Query: 237 ATC-----CSDHLHCCPQDTV-------C-------DLIQSKCLSKENATTDLLTKLP-- 275
+ C C +HL C Q+ V C L + +C + ++ P
Sbjct: 723 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 782
Query: 276 --AHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKG 333
+T G +C SC GY R SG G C C + C P G +T
Sbjct: 783 HCTNTEGSFRC----SCAPGY---RAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGS 833
Query: 334 ---TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC----CQLTSGEW 386
TC G P R C +V C D C C T G +
Sbjct: 834 FACTCAPGYRPGP------------------RGASCLDVDECSEEDLCQSGICTNTDGSF 875
Query: 387 GCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ 446
C +C H+ P +C+ +C+ + G ++ S RD
Sbjct: 876 EC------ICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 928
Query: 447 HTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPAT 506
H P G C + C + +C R P Y C +C+ QP
Sbjct: 929 HAG-PEG--TCDDVD---ECQEYGPEICGAQRCENTPGSYRC---TPACDP---GYQP-- 974
Query: 507 FLARSPHVGVKDV-ECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCA-DRRHC 558
+P G +DV EC FC + C N G C QG A D RHC
Sbjct: 975 ----TPGGGCQDVDECRNRSFCGAHAVC--QNLPGSFQCLCDQGYEGARDGRHC 1022
Score = 50.4 bits (119), Expect = 4e-06
Identities = 102/403 (25%), Positives = 121/403 (30%), Gaps = 108/403 (26%)
Query: 213 SRCPDGSTC-----------CELPSGKYGCC------PMPNATCCSDHLHCCPQDTVCDL 255
+RC D C CE G + C P A C D C CDL
Sbjct: 516 TRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL 575
Query: 256 IQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC-----------CRLQSGAW 304
+C EN L PA G SC D C C+ G++
Sbjct: 576 --GRC---ENTPGSFLCVCPA---GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSF 627
Query: 305 GC-CP--FTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK 361
C CP F + C ED C C G C+ PA P A
Sbjct: 628 RCVCPAGFRGSACEEDVDECAQEPPPCGP--GRCDNTAGSFHCA--CPAGFRSRGPGA-- 681
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG-QCQRGS 420
PC +V C S C +G C E Q CP G+ G +C+
Sbjct: 682 ---PCQDVDECARSPPPCT-----YGRCENTEG----SFQCVCPMGFQPNTAGSECEDVD 729
Query: 421 EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLP-----HAVCC 475
E C+ H +CP GQ C S GS+ C P H C
Sbjct: 730 E----------------------CENHLACP-GQECVNS-PGSFQCRTCPSGHHLHRGRC 765
Query: 476 EDRQHCCPAGYTCNVKARSCEKEV---VSAQPATFLARSPHVG-VKDV-ECGEGHFCHDN 530
D C C E S P + A S G DV EC EG FC +
Sbjct: 766 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG-YRAPSGRPGPCADVNECLEGDFCFPH 824
Query: 531 QTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
C N G C C G+R RG CL
Sbjct: 825 GECL--NTDGSFACT-------------CAPGYRPGPRGASCL 852
Score = 44.7 bits (104), Expect = 2e-04
Identities = 97/472 (20%), Positives = 129/472 (27%), Gaps = 133/472 (28%)
Query: 93 GDGHHCCPRGF-------------HCSADGRSCFQRSGNNSVGAIQC-------PDSQ-F 131
G H CP GF C+ C N+ G+ QC P++
Sbjct: 664 GSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 723
Query: 132 ECPDFSTC----------CVMVDGSWGCCPMPQA------------SCCEDRVHCCPHGA 169
EC D C CV GS+ C P C C PHG
Sbjct: 724 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 783
Query: 170 FCDLVHT-RCITPTGTH-PLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
+ + RC G P + P N L P DGS C G
Sbjct: 784 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGSFACTCAPG 841
Query: 228 KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME 287
P P C D C + DL QS + + + + + P H G
Sbjct: 842 YR---PGPRGASCLDVDECSEE----DLCQSGICTNTDGSFECICP-PGHRAG------- 886
Query: 288 VSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK 347
PD +C + C A+C P + C C+ G H P
Sbjct: 887 ---PDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRD---CDPGYHAGP---- 932
Query: 348 APAHLSLPDPQALKRDVPCDNVSSCP--SSDTC----CQLTSGEWGCCPIPEAVCCSDHQ 401
+ CD+V C + C C+ T G + C P
Sbjct: 933 ---------------EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTP----------- 966
Query: 402 HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG 461
C GY G CQ E C + C C +L
Sbjct: 967 -ACDPGYQPTPGGGCQDVDE----------------------CRNRSFCG-AHAVCQNLP 1002
Query: 462 GSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPH 513
GS+ C D +HC C C + +FL P+
Sbjct: 1003 GSFQCLCDQGYEGARDGRHCVDVN-ECETLQGVCGAALCENVEGSFLCVCPN 1053
Score = 40.4 bits (93), Expect = 0.005
Identities = 99/437 (22%), Positives = 134/437 (30%), Gaps = 102/437 (23%)
Query: 208 CPDARSR----CPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSK 263
CP R C D C ++G C A + CP + D +S C+S+
Sbjct: 277 CPTGFERVNGSCEDVDECATGGRCQHGEC----ANTRGGYTCVCPDGFLLDSSRSSCISQ 332
Query: 264 ENATTDLLTKLPAHTV-GDVKCDMEV--SCPDGYTCCRLQSGAWG-----CCPFTQAVCC 315
+ K P V D C + + + CC AWG C PF
Sbjct: 333 HVISE---AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGS---- 385
Query: 316 EDHIHCCPAG-----FTCDTQKGTCEQG----------PHQVPWMEKA-----PAHLSLP 355
E CPAG D + T G P +P + P H P
Sbjct: 386 EGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEP 445
Query: 356 DPQALKR-----DVPCDNV---------SSCPSSDTCCQ--LTSGEWGCCPIPEAVCCSD 399
P+ ++P ++ S PSS C + G C P C+
Sbjct: 446 RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC 505
Query: 400 HQ--HCCPQGYTCVAEGQCQR--------GSEIVAGLEKMPARRASLSHPRDIGCDQHTS 449
PQG C+ +C+R E G + + PR C
Sbjct: 506 DSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE 565
Query: 450 C-----PVGQTCCPSLGGSWACC------QLPHAVCCEDRQHCCPAGYTCNVKARSCEKE 498
C P C + GS+ C PH C+D C + C A C+
Sbjct: 566 CHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA--CKN- 622
Query: 499 VVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--CADRR 556
P +F P G + C E D C ++ P G C A
Sbjct: 623 ----LPGSFRCVCP-AGFRGSACEE-----DVDECAQEPP------PCGPGRCDNTAGSF 666
Query: 557 HC-CPAGFRCAARGTKC 572
HC CPAGFR G C
Sbjct: 667 HCACPAGFRSRGPGAPC 683
Score = 36.6 bits (83), Expect = 0.067
Identities = 66/279 (23%), Positives = 84/279 (30%), Gaps = 44/279 (15%)
Query: 305 GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV 364
G C VC P+G+TC C+ G +P D +R
Sbjct: 480 GMCQRNPQVCGPGRCISRPSGYTC-----ACDSG------FRLSPQGTRCIDVDECRRVP 528
Query: 365 PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVA 424
P C +S + G G P A C D C C G+C E
Sbjct: 529 PPCAPGRCENSPGSFRCVCGP-GFRAGPRAAECLDVDECHRVPPPCDL-GRC----ENTP 582
Query: 425 GLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPA 484
G + P C C T P L G AC LP + C CPA
Sbjct: 583 GSFLCVCPAGYQAAPHGASCQDVDEC----TQSPGLCGRGACKNLPGSFRC-----VCPA 633
Query: 485 GY---TCNVKARSCEKEVVSAQP-------ATFLARSPHVGVKDVECGEGHFCHDNQTCC 534
G+ C C +E P +F P G + G G C D C
Sbjct: 634 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP-AGFR--SRGPGAPCQDVDECA 690
Query: 535 RDNRQGWACCPYRQGVCCADRRHC-CPAGFRCAARGTKC 572
R C Y + C CP GF+ G++C
Sbjct: 691 RSPPP----CTYGRCENTEGSFQCVCPMGFQPNTAGSEC 725
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 58.5 bits (140), Expect = 2e-08
Identities = 146/594 (24%), Positives = 191/594 (32%), Gaps = 138/594 (23%)
Query: 17 GTRCPDGQFC--------PVACCLDPGGASYSC-CRPLLDKWPTTLSRHLGGPC-QVDAH 66
GTRC D C P C PG S+ C C P P C +V
Sbjct: 545 GTRCIDVDECRRVPPPCAPGRCENSPG--SFRCVCGPGFRAGPRAAECLDVDECHRVPPP 602
Query: 67 CSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQC 126
C G C P + C CP G+ + G SC +C
Sbjct: 603 CDLGR-----------CENTPGSFLC-----VCPAGYQAAPHGASC--------QDVDEC 638
Query: 127 PDSQFECPDFSTCCVMVDGSWGC-CPMP-QASCCEDRV-HCCPHGAFCDLVHTRCITPTG 183
S C C + GS+ C CP + S CE+ V C C RC G
Sbjct: 639 TQSPGLCG--RGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG--PGRCDNTAG 694
Query: 184 THPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC-CPM---PN--- 236
+ A PA +R + ARS P CE G + C CPM PN
Sbjct: 695 SFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAG 752
Query: 237 ATC-----CSDHLHCCPQDTV-------C-------DLIQSKCLSKENATTDLLTKLP-- 275
+ C C +HL C Q+ V C L + +C + ++ P
Sbjct: 753 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 812
Query: 276 --AHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKG 333
+T G +C SC GY R SG G C C + C P G +T
Sbjct: 813 HCTNTEGSFRC----SCAPGY---RAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGS 863
Query: 334 ---TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC----CQLTSGEW 386
TC G P R C +V C D C C T G +
Sbjct: 864 FACTCAPGYRPGP------------------RGASCLDVDECSEEDLCQSGICTNTDGSF 905
Query: 387 GCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ 446
C +C H+ P +C+ +C+ + G ++ S RD
Sbjct: 906 EC------ICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 958
Query: 447 HTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPAT 506
H P G C + C + +C R P Y C +C+ QP
Sbjct: 959 HAG-PEG--TCDDVD---ECQEYGPEICGAQRCENTPGSYRC---TPACDP---GYQP-- 1004
Query: 507 FLARSPHVGVKDV-ECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCA-DRRHC 558
+P G +DV EC FC + C N G C QG A D RHC
Sbjct: 1005 ----TPGGGCQDVDECRNRSFCGAHAVC--QNLPGSFQCLCDQGYEGARDGRHC 1052
Score = 50.4 bits (119), Expect = 4e-06
Identities = 102/403 (25%), Positives = 121/403 (30%), Gaps = 108/403 (26%)
Query: 213 SRCPDGSTC-----------CELPSGKYGCC------PMPNATCCSDHLHCCPQDTVCDL 255
+RC D C CE G + C P A C D C CDL
Sbjct: 546 TRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL 605
Query: 256 IQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC-----------CRLQSGAW 304
+C EN L PA G SC D C C+ G++
Sbjct: 606 --GRC---ENTPGSFLCVCPA---GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSF 657
Query: 305 GC-CP--FTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK 361
C CP F + C ED C C G C+ PA P A
Sbjct: 658 RCVCPAGFRGSACEEDVDECAQEPPPCGP--GRCDNTAGSFHCA--CPAGFRSRGPGA-- 711
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG-QCQRGS 420
PC +V C S C +G C E Q CP G+ G +C+
Sbjct: 712 ---PCQDVDECARSPPPCT-----YGRCENTEG----SFQCVCPMGFQPNTAGSECEDVD 759
Query: 421 EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLP-----HAVCC 475
E C+ H +CP GQ C S GS+ C P H C
Sbjct: 760 E----------------------CENHLACP-GQECVNS-PGSFQCRTCPSGHHLHRGRC 795
Query: 476 EDRQHCCPAGYTCNVKARSCEKEV---VSAQPATFLARSPHVG-VKDV-ECGEGHFCHDN 530
D C C E S P + A S G DV EC EG FC +
Sbjct: 796 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG-YRAPSGRPGPCADVNECLEGDFCFPH 854
Query: 531 QTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
C N G C C G+R RG CL
Sbjct: 855 GECL--NTDGSFACT-------------CAPGYRPGPRGASCL 882
Score = 44.7 bits (104), Expect = 2e-04
Identities = 97/472 (20%), Positives = 129/472 (27%), Gaps = 133/472 (28%)
Query: 93 GDGHHCCPRGF-------------HCSADGRSCFQRSGNNSVGAIQC-------PDSQ-F 131
G H CP GF C+ C N+ G+ QC P++
Sbjct: 694 GSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 753
Query: 132 ECPDFSTC----------CVMVDGSWGCCPMPQA------------SCCEDRVHCCPHGA 169
EC D C CV GS+ C P C C PHG
Sbjct: 754 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 813
Query: 170 FCDLVHT-RCITPTGTH-PLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
+ + RC G P + P N L P DGS C G
Sbjct: 814 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGSFACTCAPG 871
Query: 228 KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME 287
P P C D C + DL QS + + + + + P H G
Sbjct: 872 YR---PGPRGASCLDVDECSEE----DLCQSGICTNTDGSFECICP-PGHRAG------- 916
Query: 288 VSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK 347
PD +C + C A+C P + C C+ G H P
Sbjct: 917 ---PDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRD---CDPGYHAGP---- 962
Query: 348 APAHLSLPDPQALKRDVPCDNVSSCP--SSDTC----CQLTSGEWGCCPIPEAVCCSDHQ 401
+ CD+V C + C C+ T G + C P
Sbjct: 963 ---------------EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTP----------- 996
Query: 402 HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG 461
C GY G CQ E C + C C +L
Sbjct: 997 -ACDPGYQPTPGGGCQDVDE----------------------CRNRSFCG-AHAVCQNLP 1032
Query: 462 GSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPH 513
GS+ C D +HC C C + +FL P+
Sbjct: 1033 GSFQCLCDQGYEGARDGRHCVDVN-ECETLQGVCGAALCENVEGSFLCVCPN 1083
Score = 40.4 bits (93), Expect = 0.005
Identities = 99/437 (22%), Positives = 134/437 (30%), Gaps = 102/437 (23%)
Query: 208 CPDARSR----CPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSK 263
CP R C D C ++G C A + CP + D +S C+S+
Sbjct: 307 CPTGFERVNGSCEDVDECATGGRCQHGEC----ANTRGGYTCVCPDGFLLDSSRSSCISQ 362
Query: 264 ENATTDLLTKLPAHTV-GDVKCDMEV--SCPDGYTCCRLQSGAWG-----CCPFTQAVCC 315
+ K P V D C + + + CC AWG C PF
Sbjct: 363 HVISE---AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGS---- 415
Query: 316 EDHIHCCPAG-----FTCDTQKGTCEQG----------PHQVPWMEKA-----PAHLSLP 355
E CPAG D + T G P +P + P H P
Sbjct: 416 EGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEP 475
Query: 356 DPQALKR-----DVPCDNV---------SSCPSSDTCCQ--LTSGEWGCCPIPEAVCCSD 399
P+ ++P ++ S PSS C + G C P C+
Sbjct: 476 RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC 535
Query: 400 HQ--HCCPQGYTCVAEGQCQR--------GSEIVAGLEKMPARRASLSHPRDIGCDQHTS 449
PQG C+ +C+R E G + + PR C
Sbjct: 536 DSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE 595
Query: 450 C-----PVGQTCCPSLGGSWACC------QLPHAVCCEDRQHCCPAGYTCNVKARSCEKE 498
C P C + GS+ C PH C+D C + C A C+
Sbjct: 596 CHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA--CKN- 652
Query: 499 VVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--CADRR 556
P +F P G + C E D C ++ P G C A
Sbjct: 653 ----LPGSFRCVCP-AGFRGSACEE-----DVDECAQEPP------PCGPGRCDNTAGSF 696
Query: 557 HC-CPAGFRCAARGTKC 572
HC CPAGFR G C
Sbjct: 697 HCACPAGFRSRGPGAPC 713
Score = 36.6 bits (83), Expect = 0.067
Identities = 66/279 (23%), Positives = 84/279 (30%), Gaps = 44/279 (15%)
Query: 305 GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV 364
G C VC P+G+TC C+ G +P D +R
Sbjct: 510 GMCQRNPQVCGPGRCISRPSGYTC-----ACDSG------FRLSPQGTRCIDVDECRRVP 558
Query: 365 PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVA 424
P C +S + G G P A C D C C G+C E
Sbjct: 559 PPCAPGRCENSPGSFRCVCGP-GFRAGPRAAECLDVDECHRVPPPCDL-GRC----ENTP 612
Query: 425 GLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPA 484
G + P C C T P L G AC LP + C CPA
Sbjct: 613 GSFLCVCPAGYQAAPHGASCQDVDEC----TQSPGLCGRGACKNLPGSFRC-----VCPA 663
Query: 485 GY---TCNVKARSCEKEVVSAQP-------ATFLARSPHVGVKDVECGEGHFCHDNQTCC 534
G+ C C +E P +F P G + G G C D C
Sbjct: 664 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP-AGFR--SRGPGAPCQDVDECA 720
Query: 535 RDNRQGWACCPYRQGVCCADRRHC-CPAGFRCAARGTKC 572
R C Y + C CP GF+ G++C
Sbjct: 721 RSPPP----CTYGRCENTEGSFQCVCPMGFQPNTAGSEC 755
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 58.5 bits (140), Expect = 2e-08
Identities = 146/594 (24%), Positives = 191/594 (32%), Gaps = 138/594 (23%)
Query: 17 GTRCPDGQFC--------PVACCLDPGGASYSC-CRPLLDKWPTTLSRHLGGPC-QVDAH 66
GTRC D C P C PG S+ C C P P C +V
Sbjct: 582 GTRCIDVDECRRVPPPCAPGRCENSPG--SFRCVCGPGFRAGPRAAECLDVDECHRVPPP 639
Query: 67 CSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQC 126
C G C P + C CP G+ + G SC +C
Sbjct: 640 CDLGR-----------CENTPGSFLC-----VCPAGYQAAPHGASC--------QDVDEC 675
Query: 127 PDSQFECPDFSTCCVMVDGSWGC-CPMP-QASCCEDRV-HCCPHGAFCDLVHTRCITPTG 183
S C C + GS+ C CP + S CE+ V C C RC G
Sbjct: 676 TQSPGLCG--RGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG--PGRCDNTAG 731
Query: 184 THPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC-CPM---PN--- 236
+ A PA +R + ARS P CE G + C CPM PN
Sbjct: 732 SFHCA--CPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAG 789
Query: 237 ATC-----CSDHLHCCPQDTV-------C-------DLIQSKCLSKENATTDLLTKLP-- 275
+ C C +HL C Q+ V C L + +C + ++ P
Sbjct: 790 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 849
Query: 276 --AHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKG 333
+T G +C SC GY R SG G C C + C P G +T
Sbjct: 850 HCTNTEGSFRC----SCAPGY---RAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGS 900
Query: 334 ---TCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC----CQLTSGEW 386
TC G P R C +V C D C C T G +
Sbjct: 901 FACTCAPGYRPGP------------------RGASCLDVDECSEEDLCQSGICTNTDGSF 942
Query: 387 GCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ 446
C +C H+ P +C+ +C+ + G ++ S RD
Sbjct: 943 EC------ICPPGHR-AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 995
Query: 447 HTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPAT 506
H P G C + C + +C R P Y C +C+ QP
Sbjct: 996 HAG-PEG--TCDDVD---ECQEYGPEICGAQRCENTPGSYRC---TPACDP---GYQP-- 1041
Query: 507 FLARSPHVGVKDV-ECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCA-DRRHC 558
+P G +DV EC FC + C N G C QG A D RHC
Sbjct: 1042 ----TPGGGCQDVDECRNRSFCGAHAVC--QNLPGSFQCLCDQGYEGARDGRHC 1089
Score = 50.4 bits (119), Expect = 4e-06
Identities = 102/403 (25%), Positives = 121/403 (30%), Gaps = 108/403 (26%)
Query: 213 SRCPDGSTC-----------CELPSGKYGCC------PMPNATCCSDHLHCCPQDTVCDL 255
+RC D C CE G + C P A C D C CDL
Sbjct: 583 TRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL 642
Query: 256 IQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC-----------CRLQSGAW 304
+C EN L PA G SC D C C+ G++
Sbjct: 643 --GRC---ENTPGSFLCVCPA---GYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSF 694
Query: 305 GC-CP--FTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK 361
C CP F + C ED C C G C+ PA P A
Sbjct: 695 RCVCPAGFRGSACEEDVDECAQEPPPCGP--GRCDNTAGSFHCA--CPAGFRSRGPGA-- 748
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEG-QCQRGS 420
PC +V C S C +G C E Q CP G+ G +C+
Sbjct: 749 ---PCQDVDECARSPPPCT-----YGRCENTEG----SFQCVCPMGFQPNTAGSECEDVD 796
Query: 421 EIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLP-----HAVCC 475
E C+ H +CP GQ C S GS+ C P H C
Sbjct: 797 E----------------------CENHLACP-GQECVNS-PGSFQCRTCPSGHHLHRGRC 832
Query: 476 EDRQHCCPAGYTCNVKARSCEKEV---VSAQPATFLARSPHVG-VKDV-ECGEGHFCHDN 530
D C C E S P + A S G DV EC EG FC +
Sbjct: 833 TDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPG-YRAPSGRPGPCADVNECLEGDFCFPH 891
Query: 531 QTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
C N G C C G+R RG CL
Sbjct: 892 GECL--NTDGSFACT-------------CAPGYRPGPRGASCL 919
Score = 44.7 bits (104), Expect = 2e-04
Identities = 97/472 (20%), Positives = 129/472 (27%), Gaps = 133/472 (28%)
Query: 93 GDGHHCCPRGF-------------HCSADGRSCFQRSGNNSVGAIQC-------PDSQ-F 131
G H CP GF C+ C N+ G+ QC P++
Sbjct: 731 GSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGS 790
Query: 132 ECPDFSTC----------CVMVDGSWGCCPMPQA------------SCCEDRVHCCPHGA 169
EC D C CV GS+ C P C C PHG
Sbjct: 791 ECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGH 850
Query: 170 FCDLVHT-RCITPTGTH-PLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
+ + RC G P + P N L P DGS C G
Sbjct: 851 CTNTEGSFRCSCAPGYRAPSGRPGPCADVNE--CLEGDFCFPHGECLNTDGSFACTCAPG 908
Query: 228 KYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME 287
P P C D C + DL QS + + + + + P H G
Sbjct: 909 YR---PGPRGASCLDVDECSEE----DLCQSGICTNTDGSFECICP-PGHRAG------- 953
Query: 288 VSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK 347
PD +C + C A+C P + C C+ G H P
Sbjct: 954 ---PDLASCLDVDE----CRERGPALCGSQRCENSPGSYRCVRD---CDPGYHAGP---- 999
Query: 348 APAHLSLPDPQALKRDVPCDNVSSCP--SSDTC----CQLTSGEWGCCPIPEAVCCSDHQ 401
+ CD+V C + C C+ T G + C P
Sbjct: 1000 ---------------EGTCDDVDECQEYGPEICGAQRCENTPGSYRCTP----------- 1033
Query: 402 HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG 461
C GY G CQ E C + C C +L
Sbjct: 1034 -ACDPGYQPTPGGGCQDVDE----------------------CRNRSFCG-AHAVCQNLP 1069
Query: 462 GSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPH 513
GS+ C D +HC C C + +FL P+
Sbjct: 1070 GSFQCLCDQGYEGARDGRHCVDVN-ECETLQGVCGAALCENVEGSFLCVCPN 1120
Score = 40.4 bits (93), Expect = 0.005
Identities = 99/437 (22%), Positives = 134/437 (30%), Gaps = 102/437 (23%)
Query: 208 CPDARSR----CPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSK 263
CP R C D C ++G C A + CP + D +S C+S+
Sbjct: 344 CPTGFERVNGSCEDVDECATGGRCQHGEC----ANTRGGYTCVCPDGFLLDSSRSSCISQ 399
Query: 264 ENATTDLLTKLPAHTV-GDVKCDMEV--SCPDGYTCCRLQSGAWG-----CCPFTQAVCC 315
+ K P V D C + + + CC AWG C PF
Sbjct: 400 HVISE---AKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGS---- 452
Query: 316 EDHIHCCPAG-----FTCDTQKGTCEQG----------PHQVPWMEKA-----PAHLSLP 355
E CPAG D + T G P +P + P H P
Sbjct: 453 EGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEP 512
Query: 356 DPQALKR-----DVPCDNV---------SSCPSSDTCCQ--LTSGEWGCCPIPEAVCCSD 399
P+ ++P ++ S PSS C + G C P C+
Sbjct: 513 RPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCAC 572
Query: 400 HQ--HCCPQGYTCVAEGQCQR--------GSEIVAGLEKMPARRASLSHPRDIGCDQHTS 449
PQG C+ +C+R E G + + PR C
Sbjct: 573 DSGFRLSPQGTRCIDVDECRRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDE 632
Query: 450 C-----PVGQTCCPSLGGSWACC------QLPHAVCCEDRQHCCPAGYTCNVKARSCEKE 498
C P C + GS+ C PH C+D C + C A C+
Sbjct: 633 CHRVPPPCDLGRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA--CKN- 689
Query: 499 VVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--CADRR 556
P +F P G + C E D C ++ P G C A
Sbjct: 690 ----LPGSFRCVCP-AGFRGSACEE-----DVDECAQEPP------PCGPGRCDNTAGSF 733
Query: 557 HC-CPAGFRCAARGTKC 572
HC CPAGFR G C
Sbjct: 734 HCACPAGFRSRGPGAPC 750
Score = 36.6 bits (83), Expect = 0.067
Identities = 66/279 (23%), Positives = 84/279 (30%), Gaps = 44/279 (15%)
Query: 305 GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV 364
G C VC P+G+TC C+ G +P D +R
Sbjct: 547 GMCQRNPQVCGPGRCISRPSGYTC-----ACDSG------FRLSPQGTRCIDVDECRRVP 595
Query: 365 PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVA 424
P C +S + G G P A C D C C G+C E
Sbjct: 596 PPCAPGRCENSPGSFRCVCGP-GFRAGPRAAECLDVDECHRVPPPCDL-GRC----ENTP 649
Query: 425 GLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPA 484
G + P C C T P L G AC LP + C CPA
Sbjct: 650 GSFLCVCPAGYQAAPHGASCQDVDEC----TQSPGLCGRGACKNLPGSFRC-----VCPA 700
Query: 485 GY---TCNVKARSCEKEVVSAQP-------ATFLARSPHVGVKDVECGEGHFCHDNQTCC 534
G+ C C +E P +F P G + G G C D C
Sbjct: 701 GFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP-AGFR--SRGPGAPCQDVDECA 757
Query: 535 RDNRQGWACCPYRQGVCCADRRHC-CPAGFRCAARGTKC 572
R C Y + C CP GF+ G++C
Sbjct: 758 RSPPP----CTYGRCENTEGSFQCVCPMGFQPNTAGSEC 792
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 58.2 bits (139), Expect = 2e-08
Identities = 153/635 (24%), Positives = 197/635 (31%), Gaps = 156/635 (24%)
Query: 10 LTAGLVAGTRC---PDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPC----- 61
L++ G RC PDG+F C P G CR +D+ GG C
Sbjct: 124 LSSPCAHGARCSVGPDGRFL----CSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPG 179
Query: 62 QVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRG---FHCSA----DGRSCFQ 114
C AG++ + C P P C +G C G + C+ +G++C
Sbjct: 180 SFRCQCPAGYTGPLCENPAVPCAPSP----CRNGGTCRQSGDLTYDCACLPGFEGQNC-- 233
Query: 115 RSGNNSVGAIQCPDSQFECPDFSTCCVMVDG--SWGC-CPMPQAS--CCEDRVHCCPHGA 169
V CP + C + TC VDG ++ C CP C ED C
Sbjct: 234 -----EVNVDDCPGHR--CLNGGTC---VDGVNTYNCQCPPEWTGQFCTEDVDECQLQPN 283
Query: 170 FCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPD-ARSRCPDGSTC------- 221
C T C G H N S S D A + C G+TC
Sbjct: 284 ACHNGGT-CFNTLGGHSCVC------VNGWTGESCSQNIDDCATAVCFHGATCHDRVASF 336
Query: 222 -CELPSGKYGCCPMPNATCCSDHLH-----------------CCPQDT--VCDLIQSKCL 261
C P GK G + C S+ H C P T CD +C
Sbjct: 337 YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
Query: 262 SKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCC--PFTQAVCCEDHI 319
N L +T G C C GYT R ++ C P C D I
Sbjct: 397 IGANPCEHL--GRCVNTQGSFLC----QCGRGYTGPRCETDVNECLSGPCRNQATCLDRI 450
Query: 320 H----CCPAGFT---CDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVS-- 370
C AGFT C+ C+ P + V D V+
Sbjct: 451 GQFTCICMAGFTGTYCEVDIDECQSSP-------------------CVNGGVCKDRVNGF 491
Query: 371 --SCPS--SDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSE-IVAG 425
+CPS S + CQL E P C D P GY C +C G E +
Sbjct: 492 SCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQ----PDGYEC----RCAEGFEGTLCD 543
Query: 426 LEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLP--------HAVCC-- 475
H R + SC C P G+ Q+ H C
Sbjct: 544 RNVDDCSPDPCHHGRCVDGIASFSC----ACAPGYTGTRCESQVDECRSQPCRHGGKCLD 599
Query: 476 -EDRQHC-CPAGYT---CNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDN 530
D+ C CP+G T C V C ++ P TF + D C G
Sbjct: 600 LVDKYLCRCPSGTTGVNCEVNIDDC-----ASNPCTFGVCRDGINRYDCVCQPGF----T 650
Query: 531 QTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRC 565
C A P +G C D + GFRC
Sbjct: 651 GPLCNVEINECASSPCGEGGSCVDGEN----GFRC 681
Score = 48.9 bits (115), Expect = 1e-05
Identities = 152/655 (23%), Positives = 198/655 (30%), Gaps = 169/655 (25%)
Query: 51 TTLSRHLGGPCQVDAHCS---AGHSCIFTVSGTSSCC----------PFPEAVACGD--- 94
T ++ L GPC+ A C +CI T + C P C D
Sbjct: 430 TDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVN 489
Query: 95 GHHC-CPRGFH---CSADGRSCFQRSGNNSVGAIQCPDSQFEC----------------- 133
G C CP GF C D C N + PD +EC
Sbjct: 490 GFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG-YECRCAEGFEGTLCDRNVDD 548
Query: 134 --PDFSTCCVMVDG----SWGCCPMPQASCCEDRV-HC----CPHGAFC-DLVHTR-CIT 180
PD VDG S C P + CE +V C C HG C DLV C
Sbjct: 549 CSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC 608
Query: 181 PTGT--------------HPLAKKLPAQRTNRAVALS----SSVMC-----PDARSRCPD 217
P+GT +P + NR + + +C A S C +
Sbjct: 609 PSGTTGVNCEVNIDDCASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE 668
Query: 218 GSTCCELPSGKYGCCPMPN-ATCCSDHLHCCPQD---------------TVCDLIQSKCL 261
G +C + +G CP + C H C + VC+ S
Sbjct: 669 GGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPR 728
Query: 262 SKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC 321
++ D P G D G+ C C P Q CE C
Sbjct: 729 CSQSLARDACESQPCRAGGTCSSD-----GMGFHCT--------CPPGVQGRQCELLSPC 775
Query: 322 CPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV-PCDNVSSCPSSDTCCQ 380
P C+ G CE P Q+P + P P Q +DV C + C C
Sbjct: 776 TPN--PCE-HGGRCESAPGQLP-VCSCPQGWQGPRCQ---QDVDECAGPAPCGPHGICTN 828
Query: 381 LTSGEWGCC---PIPEAVCCSDHQHCCPQGYTCVAEGQCQR--GSEIVAGLEKMPARRAS 435
L +G + C C D C P C+ G CQ GS + L R +
Sbjct: 829 L-AGSFSCTCHGGYTGPSCDQDINDCDPN--PCLNGGSCQDGVGSFSCSCLPGFAGPRCA 885
Query: 436 LSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
RD+ D+ S P G C S+ C CP GY C
Sbjct: 886 ----RDV--DECLSNPCGPGTCTDHVASFTC--------------TCPPGY----GGFHC 921
Query: 496 EKEVVSAQPATFLARSPHV-GVKDVEC------GEGHFCHDNQTC----------CRDNR 538
E+++ P++ V GV C H H+ C C
Sbjct: 922 EQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAH 981
Query: 539 QGWACC-------PYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRD 586
G+ C P Q + R C G RC G CL P W L D
Sbjct: 982 PGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLC--PPGWSGRLCD 1034
Score = 46.2 bits (108), Expect = 8e-05
Identities = 92/394 (23%), Positives = 127/394 (32%), Gaps = 58/394 (14%)
Query: 213 SRCPDGSTCCELPSGKYGC-CP---MPNATCCSDHLHC--CPQDTVCDLIQSKCLSKENA 266
S C +G C +LPS + C CP + D H C VC QS ++
Sbjct: 47 SPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVC---QSSVVA---G 100
Query: 267 TTDLLTKLPAHTVGDVKCDMEVSC--------------PDGYTCCRLQSGAWGCCPFTQA 312
T + P G C + C PDG C C P Q
Sbjct: 101 TARFSCRCPRGFRGP-DCSLPDPCLSSPCAHGARCSVGPDGRFLC-------SCPPGYQG 152
Query: 313 VCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSC 372
C + C G C GTC P + P VPC S C
Sbjct: 153 RSCRSDVDECRVGEPC-RHGGTCLNTPGSF----RCQCPAGYTGPLCENPAVPC-APSPC 206
Query: 373 PSSDTCCQLTSGEWGCCPIP--EAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMP 430
+ TC Q + C +P E C + CP G+ C+ G C G + P
Sbjct: 207 RNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCP-GHRCLNGGTCVDGVNTYNC--QCP 263
Query: 431 ARRASLSHPRDIG-CD-QHTSCPVGQTCCPSLGGSWACC--QLPHAVCCEDRQHCCPAGY 486
D+ C Q +C G TC +LGG C C ++ C A
Sbjct: 264 PEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATA-- 321
Query: 487 TCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCP- 545
C +C V S A + ++ + D C + CH++ C + G A C
Sbjct: 322 VC-FHGATCHDRVASFYCACPMGKTGLLCHLDDAC-VSNPCHEDAICDTNPVNGRAICTC 379
Query: 546 ---YRQGVCCADRRHCCPAGFRCAARGTKCLRRE 576
+ G C D C C G +C+ +
Sbjct: 380 PPGFTGGACDQDVDECSIGANPCEHLG-RCVNTQ 412
Score = 45.4 bits (106), Expect = 1e-04
Identities = 72/262 (27%), Positives = 88/262 (33%), Gaps = 59/262 (22%)
Query: 339 PHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGC-CP---IPEA 394
P P + P L L P A PC + S C + C QL S E C CP + E
Sbjct: 18 PPPPPPVRALPLLLLLAGPGAAAP--PCLDGSPCANGGRCTQLPSREAACLCPPGWVGER 75
Query: 395 VCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQ 454
D H P C G CQ S +VAG R S PR + C +
Sbjct: 76 CQLEDPCHSGP----CAGRGVCQ--SSVVAG-----TARFSCRCPRGF---RGPDCSLPD 121
Query: 455 TCCPSLGGSWACCQLPHAVCCEDRQHC-CPAGYTCNVKARSCEKEVVSAQ---------- 503
C S A C +V + R C CP GY + RSC +V +
Sbjct: 122 PCLSSPCAHGARC----SVGPDGRFLCSCPPGY----QGRSCRSDVDECRVGEPCRHGGT 173
Query: 504 ----PATF-----------LARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
P +F L +P V C G C + D AC P +
Sbjct: 174 CLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYD----CACLPGFE 229
Query: 549 GVCCADRRHCCPAGFRCAARGT 570
G C CP G RC GT
Sbjct: 230 GQNCEVNVDDCP-GHRCLNGGT 250
Score = 44.3 bits (103), Expect = 3e-04
Identities = 137/610 (22%), Positives = 184/610 (30%), Gaps = 177/610 (29%)
Query: 16 AGTRCPDGQFCPVA--CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSC 73
A C DG C C P + C P W +G CQ++ C +G
Sbjct: 39 AAPPCLDGSPCANGGRCTQLPSREAACLCPP---GW-------VGERCQLEDPCHSG--- 85
Query: 74 IFTVSGTSSCCPFPEAVACGDGHHCC--PRGFHCSADGRSCFQRSGNNSVGAIQCPDSQF 131
+G C +V G C PRGF G C ++ P
Sbjct: 86 --PCAGRGVC---QSSVVAGTARFSCRCPRGFR----GPDC----------SLPDPCLSS 126
Query: 132 ECPDFSTCCVMVDGSWGC-CP--MPQASCCEDRVHC-----CPHGAFCDLVHT----RCI 179
C + C V DG + C CP SC D C C HG C ++T RC
Sbjct: 127 PCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTC--LNTPGSFRCQ 184
Query: 180 TPTG-THPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNAT 238
P G T PL + N AV P A S C +G TC + Y C +P
Sbjct: 185 CPAGYTGPLCE-------NPAV--------PCAPSPCRNGGTCRQSGDLTYDCACLPGF- 228
Query: 239 CCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCR 298
+ C++ C P H +C +C DG
Sbjct: 229 ----------EGQNCEVNVDDC--------------PGH-----RCLNGGTCVDGVNTYN 259
Query: 299 LQSGAWGCCP--FTQAVCCEDHIHC------CPAGFTCDTQKG----TCEQGPHQVPWME 346
Q CP +T C ED C C G TC G C G W
Sbjct: 260 CQ------CPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG-----W-- 306
Query: 347 KAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQ 406
++ +++ + C TC + + CP+ +
Sbjct: 307 ---------TGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKT------------ 345
Query: 407 GYTCVAEGQCQRG---SEIVAGLEKMPARRASLSHPRDIG--CDQHT-SCPVGQTCCPSL 460
G C + C + + + R P G CDQ C +G C L
Sbjct: 346 GLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHL 405
Query: 461 GGSWACCQLPHAVCCEDRQHCCPAGYT---CNVKARSCEKEVVSAQPATFLARSPHVGVK 517
G C + C+ C GYT C C Q AT L R
Sbjct: 406 G---RCVNTQGSFLCQ-----CGRGYTGPRCETDVNECLSGPCRNQ-ATCLDRIGQFTCI 456
Query: 518 DVECGEGHFCH-DNQTC----------CRDNRQGWAC-CP--YRQGVCCADRRHCCPAGF 563
+ G +C D C C+D G++C CP + C D C
Sbjct: 457 CMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC 516
Query: 564 RCAARGTKCL 573
R G KC+
Sbjct: 517 R---NGAKCV 523
Score = 44.3 bits (103), Expect = 3e-04
Identities = 129/545 (23%), Positives = 172/545 (31%), Gaps = 129/545 (23%)
Query: 31 CLDPGGASYSC-CRPLLDKWPTTLSRH-----LGGPCQVDAHCSAGH-----SCI--FTV 77
C+D G S+SC CRP + +H L PC CSA H +C+ FT
Sbjct: 939 CVD-GVNSFSCLCRP---GYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTG 994
Query: 78 SGTSSCCPFPEAVACGDGHHCCPRGFHCSA----DGRSCFQRS-------GNNSVGAIQC 126
+ + C +G C G +C GR C RS V Q
Sbjct: 995 PQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQL 1054
Query: 127 PDSQFEC--PDFSTCCVMVDGSWG-------------------------------CCPMP 153
+ +C D S CV +G G C P
Sbjct: 1055 CQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGY 1114
Query: 154 QASCCEDRV-HC----CPHGAFC-DLV-HTRCITPTGTHPLAKKLPAQRTNRAVALSSSV 206
CED V C C HG C DLV C P GT + ++ L
Sbjct: 1115 NGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPL---- 1170
Query: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNAT---CCSDHLHCCPQDTVCDLIQSK-CLS 262
D+ RC TC +L G CP P T C +D C + C ++ CL
Sbjct: 1171 ---DSGPRCLHNGTCVDLVGGFRCTCP-PGYTGLRCEADINEC--RSGACHAAHTRDCLQ 1224
Query: 263 KENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC-----CRLQSGAWGCCPFTQAVCCED 317
L +C +S + C CR G G FT
Sbjct: 1225 DPGGGFRCLCHA---GFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFT------- 1274
Query: 318 HIHCCPA--GFTCDTQKGTCE--QGPHQVPWME-------KAPAHLSLPDPQALKRDVPC 366
HC G C+ +C Q P VP + P LS P ++ P
Sbjct: 1275 -CHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPG 1333
Query: 367 DNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYT---CVAEGQCQRGSEIV 423
+ +SC ++ L G P+ C+ C QG+T C A SE
Sbjct: 1334 ASNASCAAAPC---LHGGSCRPAPLAPFFRCA-----CAQGWTGPRCEAPAAAPEVSE-- 1383
Query: 424 AGLEKMPARRASLSHPRDIGCDQHTSCP----VGQTCCPSLGGSWACCQLPHAVCCEDRQ 479
E R A + D CD+ + P G C S+G W C+ +
Sbjct: 1384 ---EPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS 1440
Query: 480 HCCPA 484
C PA
Sbjct: 1441 RCDPA 1445
>gi|38490571 keratin associated protein 10-7 [Homo sapiens]
Length = 370
Score = 57.8 bits (138), Expect = 3e-08
Identities = 89/374 (23%), Positives = 120/374 (32%), Gaps = 88/374 (23%)
Query: 140 CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTG--THPLAKKLPAQRTN 197
C SW P+ SCCE CC LV TP + P +
Sbjct: 25 CDSCSDSWQVDDCPE-SCCEPP--CCAPAPCLSLV----CTPVSYVSSPCCRVTCEPSPC 77
Query: 198 RAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCC-PMPNATCCSDHLHCCPQDTVCDLI 256
++ SS +S C CC + CC P+ T C ++C P VC
Sbjct: 78 QSGCTSSCTPSCCQQSSCQ--LACCASSPCQQACCVPVCCKTVCCKPVYCVP---VCS-- 130
Query: 257 QSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCE 316
GD C + SC CC CC +CC+
Sbjct: 131 -----------------------GDSSCCQQSSCQSA--CCTSSPCQQACCV---PICCK 162
Query: 317 DHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDN--VSSCPS 374
C +C C+Q + +S P QA+ PC + +SSC
Sbjct: 163 PV--CSGISSSC------CQQS--------SCVSCVSSPCCQAVCEPSPCQSGCISSCTP 206
Query: 375 SDTCCQLTSGEWGCC---PIPEAVC-------------CSDHQHCCPQGYTCVAEGQCQR 418
S CCQ +S + CC P +A C CSD C Q C Q Q+
Sbjct: 207 S--CCQQSSCKPACCTSSPCQQACCVPVCCKPVCCVPTCSDDSGSCCQP-ACCTSSQSQQ 263
Query: 419 GSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVG---QTCC-PSLGGSWACCQLPHAVC 474
G + + P + C Q +SC +CC PS S C + C
Sbjct: 264 GCCVPVCCK--PVCCVPVCSGASTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPVCRPAC 321
Query: 475 CEDRQHCCPAGYTC 488
C CC +C
Sbjct: 322 CVPVPSCCAPTSSC 335
Score = 54.3 bits (129), Expect = 3e-07
Identities = 91/400 (22%), Positives = 124/400 (31%), Gaps = 77/400 (19%)
Query: 105 CSAD----GRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQAS--CC 158
CS+D R C S ++ + Q D C + C S C P+ S CC
Sbjct: 9 CSSDLSYGSRVCLPGSCDSCSDSWQVDDCPESCCEPPCCAPAPCLSLVCTPVSYVSSPCC 68
Query: 159 EDRVHC----CPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSR 214
RV C C G + C + P Q+ +V C
Sbjct: 69 --RVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKPVYCV 126
Query: 215 --CPDGSTCCELPSGKYGCCPM-PNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLL 271
C S+CC+ S + CC P C + C P VC I S C + + + +
Sbjct: 127 PVCSGDSSCCQQSSCQSACCTSSPCQQACCVPICCKP---VCSGISSSCCQQSSCVSCVS 183
Query: 272 TKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCC---PFTQAVC---CEDHIHCCPAG 325
+ C +CC+ S CC P QA C C + C P
Sbjct: 184 SPCCQAVCEPSPCQSGCISSCTPSCCQQSSCKPACCTSSPCQQACCVPVCCKPVCCVP-- 241
Query: 326 FTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGE 385
TC G+C Q PA CC + +
Sbjct: 242 -TCSDDSGSCCQ-----------PA---------------------------CCTSSQSQ 262
Query: 386 WGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRAS----LSHPRD 441
GCC +P VCC CC + + CQ+ S A R +S L P
Sbjct: 263 QGCC-VP--VCCKPV--CCVPVCSGASTSCCQQSSCQPACCTTSCCRPSSSVSLLCRPV- 316
Query: 442 IGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHC 481
C PV C P+ +CC+ V R C
Sbjct: 317 --CRPACCVPVPSCCAPTSSCQASCCRPASCVSLLCRPAC 354
Score = 54.3 bits (129), Expect = 3e-07
Identities = 75/323 (23%), Positives = 100/323 (30%), Gaps = 44/323 (13%)
Query: 26 CPVACCLDPGGASYSC----CRPL-LDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGT 80
CP +CC P A C C P+ P PCQ S SC S
Sbjct: 37 CPESCCEPPCCAPAPCLSLVCTPVSYVSSPCCRVTCEPSPCQSGCTSSCTPSCCQQSSCQ 96
Query: 81 SSCC---PFPEA--------VACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDS 129
+CC P +A C +C P CS D SC Q+S S P
Sbjct: 97 LACCASSPCQQACCVPVCCKTVCCKPVYCVPV---CSGDS-SCCQQSSCQSACCTSSPCQ 152
Query: 130 QFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAK 189
Q CCV + CC + C CC + V + C + +
Sbjct: 153 Q-------ACCVPI-----CC---KPVCSGISSSCCQQSSCVSCVSSPCC-----QAVCE 192
Query: 190 KLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQ 249
P Q + S + C S C + C P+ CSD C Q
Sbjct: 193 PSPCQSGCISSCTPSCCQQSSCKPACCTSSPCQQACCVPVCCKPVCCVPTCSDDSGSCCQ 252
Query: 250 DTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDG---YTCCRLQSG-AWG 305
C QS+ + +P + C + SC +CCR S +
Sbjct: 253 PACCTSSQSQQGCCVPVCCKPVCCVPVCSGASTSCCQQSSCQPACCTTSCCRPSSSVSLL 312
Query: 306 CCPFTQAVCCEDHIHCCPAGFTC 328
C P + CC CC +C
Sbjct: 313 CRPVCRPACCVPVPSCCAPTSSC 335
Score = 48.1 bits (113), Expect = 2e-05
Identities = 72/342 (21%), Positives = 105/342 (30%), Gaps = 93/342 (27%)
Query: 310 TQAVCCEDHIH----CCPAGFTCDT-----QKGTCEQGPHQVPWMEKAP---------AH 351
T +VC D + C P +CD+ Q C + + P AP ++
Sbjct: 5 TMSVCSSDLSYGSRVCLPG--SCDSCSDSWQVDDCPESCCEPPCCAPAPCLSLVCTPVSY 62
Query: 352 LSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCC---PIPEAVC------------ 396
+S P + PC + + + +CCQ +S + CC P +A C
Sbjct: 63 VSSPCCRVTCEPSPCQSGCTSSCTPSCCQQSSCQLACCASSPCQQACCVPVCCKTVCCKP 122
Query: 397 ------CSDHQHCCPQG---YTCVAEGQCQRG-------SEIVAGL-------------- 426
CS CC Q C CQ+ + +G+
Sbjct: 123 VYCVPVCSGDSSCCQQSSCQSACCTSSPCQQACCVPICCKPVCSGISSSCCQQSSCVSCV 182
Query: 427 ---------EKMPARRASLSHPRDIGCDQH-------TSCPVGQTCCPSLGGSWACCQLP 470
E P + +S C Q TS P Q CC + CC
Sbjct: 183 SSPCCQAVCEPSPCQSGCISSCTPSCCQQSSCKPACCTSSPCQQACCVPVCCKPVCCV-- 240
Query: 471 HAVCCEDRQHCC-PAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHD 529
C +D CC PA T + + C V +P + P C + C
Sbjct: 241 -PTCSDDSGSCCQPACCTSSQSQQGC-CVPVCCKPVCCV---PVCSGASTSCCQQSSCQP 295
Query: 530 ---NQTCCRDNRQ-GWACCPYRQGVCCADRRHCCPAGFRCAA 567
+CCR + C P + CC CC C A
Sbjct: 296 ACCTTSCCRPSSSVSLLCRPVCRPACCVPVPSCCAPTSSCQA 337
Score = 29.6 bits (65), Expect = 8.2
Identities = 40/146 (27%), Positives = 50/146 (34%), Gaps = 20/146 (13%)
Query: 20 CPDGQFCPVACCLDPGGASYSCCRPLLDK---WPTTLSRHLGGPCQVDAHCSAGHS---C 73
C C ACC +CC P+ K T S G CQ A C++ S C
Sbjct: 208 CCQQSSCKPACCTS-SPCQQACCVPVCCKPVCCVPTCSDDSGSCCQ-PACCTSSQSQQGC 265
Query: 74 IFTVSGTSSCCPFPEAVACGDGHHCCPRGF-HCSADGRSCFQRSGNNSVGAIQCPDSQFE 132
V CC V G CC + + SC + S +SV + P +
Sbjct: 266 CVPVCCKPVCCV---PVCSGASTSCCQQSSCQPACCTTSCCRPS--SSVSLLCRPVCR-- 318
Query: 133 CPDFSTCCVMVDGSWGCCPMPQASCC 158
CCV V QASCC
Sbjct: 319 ----PACCVPVPSCCAPTSSCQASCC 340
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 57.4 bits (137), Expect = 4e-08
Identities = 129/608 (21%), Positives = 187/608 (30%), Gaps = 163/608 (26%)
Query: 67 CSAGHSCIFTVSGTSSCCPFP-----EAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSV 121
CS G CI T CP V C D C + G C + N +
Sbjct: 2182 CSNGQ-CINTDGSFRCECPMGYNLDYTGVRCVDTDEC--------SIGNPCGNGTCTNVI 2232
Query: 122 GAIQC-------PDSQFECPDFSTC----------CVMVDGSWGC-CPMPQA-----SCC 158
G+ +C P C D + C C+ GS+ C CP+ A C
Sbjct: 2233 GSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMC 2292
Query: 159 EDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDG 218
+D C C+ C GT +CP +R PDG
Sbjct: 2293 KDLDECAEGLHDCESRGMMCKNLIGTF-------------------MCICPPGMARRPDG 2333
Query: 219 STCCELPS--GKYGCCPMPNATC----------CSDHLHCCPQDTVC----------DLI 256
C + K G C N C C++ T C +++
Sbjct: 2334 EGCVDENECRTKPGICE--NGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVL 2391
Query: 257 QSKCLSKENATTDLLTKLPAHTVGDV----KCDM---------EVSCPDG--YTC----- 296
Q+ C +++ +L+TK G +C++ + CP G YT
Sbjct: 2392 QTIC-QMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDI 2450
Query: 297 --CRLQSGAWGCCPFTQAVCCEDHIHC-CPAGFTCDTQKGT-------CEQGPHQVPWME 346
C++ C Q + C C G+T D GT C Q P ++
Sbjct: 2451 DECKVMPNL---CTNGQCINTMGSFRCFCKVGYTTDIS-GTSCIDLDECSQSPKPCNYIC 2506
Query: 347 K---APAHLSLPDPQALKRD-VPCDNVSSCPSSDTCCQL----TSGEWGC-CP---IPEA 394
K S P L+ D C ++ C + CQ T G + C CP
Sbjct: 2507 KNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHH 2566
Query: 395 VCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQ 454
C D+ C Q C A+G CQ G +R + C+ C
Sbjct: 2567 TACIDNNECGSQPSLCGAKGICQN----TPGSFSCECQRGFSLDATGLNCEDVDECDGNH 2622
Query: 455 TC---CPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARS 511
C C ++ G + C CP GY + + C E + P + S
Sbjct: 2623 RCQHGCQNILGGYRC--------------GCPQGYIQHYQWNQCVDENECSNPNACGSAS 2668
Query: 512 PH--VGVKDVECGEG-------HFCHD-NQTCCRDNRQGWACCPYRQGVCCADRRHCCPA 561
+ +G C G CHD N+ N + C G C CP
Sbjct: 2669 CYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCG-----CPP 2723
Query: 562 GFRCAARG 569
G+ +G
Sbjct: 2724 GYYRVGQG 2731
Score = 49.7 bits (117), Expect = 8e-06
Identities = 128/583 (21%), Positives = 180/583 (30%), Gaps = 160/583 (27%)
Query: 84 CPFPEAVACGDGHHC-CPRGFHCSADGRSCFQRS-----GNNSVGAIQCPDSQFECPDFS 137
C F G C CP GF S +GR CF N G P + F
Sbjct: 2067 CLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKA-FNTTKAK 2125
Query: 138 TCCVMVDG-SWG----CCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLP 192
CC + G WG CP +D CP+G H L
Sbjct: 2126 CCCSKMPGEGWGDPCELCPKDDEVAFQD---LCPYG----------------HGTVPSLH 2166
Query: 193 AQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG------KYGCC---------PMPNA 237
R + L S +C + + DGS CE P G C P N
Sbjct: 2167 DTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNG 2226
Query: 238 TC----------CSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPA-HTVGDVKCDM 286
TC C++ P D+ E A LL +T G +C
Sbjct: 2227 TCTNVIGSFECNCNEGFEPGPMMNCEDI-------NECAQNPLLCAFRCMNTFGSYEC-- 2277
Query: 287 EVSCPDGYT-------CCRLQSGAWGC--CPFTQAVCCEDHIH----CCPAGFT------ 327
+CP GY C L A G C ++ + C++ I CP G
Sbjct: 2278 --TCPIGYALREDQKMCKDLDECAEGLHDCE-SRGMMCKNLIGTFMCICPPGMARRPDGE 2334
Query: 328 -------CDTQKGTCEQG-----------PHQVPWMEKAPAHLSLPDPQAL----KRDVP 365
C T+ G CE G + + L + Q L
Sbjct: 2335 GCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTI 2394
Query: 366 CDNVSS----CPSSDTCCQLTSGEWG----CCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ 417
C SS S+ CC G WG CP+P + ++ CP G +G+
Sbjct: 2395 CQMASSSRNLVTKSECCCDGGRG-WGHQCELCPLPGT---AQYKKICPHGPGYTTDGRDI 2450
Query: 418 RGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWAC-CQLPH----- 471
+++ L C GQ C + GS+ C C++ +
Sbjct: 2451 DECKVMPNL-----------------------CTNGQ--CINTMGSFRCFCKVGYTTDIS 2485
Query: 472 AVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDV-ECGEGHFCHDN 530
C D C + CN ++ E + P ++ + KD+ EC H+
Sbjct: 2486 GTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQ--HNC 2543
Query: 531 QTCCRDNRQGWAC-CP---YRQGVCCADRRHCCPAGFRCAARG 569
Q C + G+ C CP + C D C C A+G
Sbjct: 2544 QFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKG 2586
Score = 48.5 bits (114), Expect = 2e-05
Identities = 124/588 (21%), Positives = 169/588 (28%), Gaps = 167/588 (28%)
Query: 119 NSVGAIQCP--------DSQFECPDFSTC------------CVMVDGSWGC-----CPMP 153
N +G+ +C D C D C C+ GS+ C +
Sbjct: 1826 NQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLS 1885
Query: 154 QASCCEDRVHC------CPHGAFCDLVHT-RCITPTGTHPLAKKLPAQRTNRAVALSSSV 206
C DR C C HG DL + +CI G A
Sbjct: 1886 PNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK---------------ASQDQT 1930
Query: 207 MCPDARS--RCPDGSTCCELPSGKYGCCPMP------NATC-----CSDHLHCCPQDTVC 253
MC D R P G+ C+ G Y C P N C CS ++ C
Sbjct: 1931 MCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRC 1990
Query: 254 --DLIQSKCLSKENATTDLLTKLPAHTVGDVKC-DMEVSCPDGYTCCRLQSGAWGCCPFT 310
++ KCL E LT + + +C + SC G TC L+ CP
Sbjct: 1991 FNEIGSFKCLCNEGYE---LTPDGKNCIDTNECVALPGSCSPG-TCQNLEGSFRCICPPG 2046
Query: 311 QAV----------CCEDHIHC---------------CPAGFTCDTQKGTCEQGPHQVPWM 345
V C ED C CP GF C +
Sbjct: 2047 YEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFT 2106
Query: 346 EKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGE-WG----CCPIPEAVCCSDH 400
S+P + + CC GE WG CP + V D
Sbjct: 2107 NFENGKCSVP------------KAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQD- 2153
Query: 401 QHCCPQGYTCV---------------AEGQCQRGSEI-VAGLEKMPARRASLSHPRDIGC 444
CP G+ V + G C G I G + + C
Sbjct: 2154 --LCPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC 2211
Query: 445 DQHTSCPVGQTC----CPSLGGSWAC-----CQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
C +G C C ++ GS+ C + + CED C C + +
Sbjct: 2212 VDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNT 2271
Query: 496 EKEVVSAQPATFLARSPHVGVKDV-ECGEG-HFCHDNQTCCRDNRQGWAC-CP-----YR 547
P + R KD+ EC EG H C C++ + C CP
Sbjct: 2272 FGSYECTCPIGYALREDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRP 2331
Query: 548 QGVCCADRRHC----------------------CPAGFRCAARGTKCL 573
G C D C C GF+ ++ GT+CL
Sbjct: 2332 DGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECL 2379
Score = 44.7 bits (104), Expect = 2e-04
Identities = 130/649 (20%), Positives = 197/649 (30%), Gaps = 149/649 (22%)
Query: 30 CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFT--VSGTSSCCPFP 87
C PG +Y CR + + + + + +C+ C + + G+ C P
Sbjct: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDME-ERNCTDIDECRISPDLCGSGICVNTP 1135
Query: 88 EAVACG--DGHHC-------CPRGFHCSADGRSCFQRSGNNSVGAIQCP--------DSQ 130
+ C +G+ C C + C + N+ G+ QC S+
Sbjct: 1136 GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSR 1195
Query: 131 FECPDFSTC-----------CVMVDGSWGCC------PMPQASCCEDRVHCCPHGAFCDL 173
+C D + C CV + G++ C P C D C CD
Sbjct: 1196 EDCVDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCD- 1254
Query: 174 VHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCP 233
T+C G++ + + + C + C DG C +P G+Y C
Sbjct: 1255 --TQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDIC-DGGQCTNIP-GEYRCLC 1310
Query: 234 MPNATCCSDHLHCCPQDTVCDLIQSKCL-------------------SKENATTDLLTKL 274
D + C CDL + C+ S + TT T +
Sbjct: 1311 YDGFMASMD-MKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGC-TDV 1368
Query: 275 PAHTVGDVKCDMEVSC---PDGYTC-CR---------------LQSGAWGCCPFTQAVCC 315
+G CDM SC P + C CR +G C Q V
Sbjct: 1369 DECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNT 1428
Query: 316 EDHIHC-CPAGFT-----------CDTQKGTCEQGPH-QVPWMEKAPAHLSLPDPQALKR 362
C C GFT C CE G VP + + P + R
Sbjct: 1429 PGSYRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFT-PASDSR 1487
Query: 363 DVPCDNVSSCPSSDTC----CQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQR 418
C ++ C + C C G + C C D G C +C
Sbjct: 1488 S--CQDIDECSFQNICVFGTCNNLPGMFHCI-------CDDGYELDRTGGNCTDIDECAD 1538
Query: 419 GSEIVAGLEKMPARRASLSHPRD-------IGC----------------DQHTSCP---- 451
V GL R + P D +GC D SC
Sbjct: 1539 PINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIG 1598
Query: 452 VG---QTCCPSLGGSWA-CCQLPHAVCCEDRQHCCPAGYTCNVKARS-CEKEVVSAQPAT 506
VG +CC SLG +W C+ V + CP G + +++ Q
Sbjct: 1599 VGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELP 1658
Query: 507 FLARSPH----VGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC 551
L + + G EC +G++ ++ C D + C GVC
Sbjct: 1659 GLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDE----CFAHPGVC 1703
Score = 38.5 bits (88), Expect = 0.018
Identities = 86/395 (21%), Positives = 116/395 (29%), Gaps = 104/395 (26%)
Query: 61 CQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRS--------- 111
C D GH C CP P CP G + DGR
Sbjct: 2410 CCCDGGRGWGHQC--------ELCPLP---GTAQYKKICPHGPGYTTDGRDIDECKVMPN 2458
Query: 112 -CFQRSGNNSVGAIQC--------PDSQFECPDFSTC----------CVMVDGSWGC-CP 151
C N++G+ +C S C D C C +GS+ C CP
Sbjct: 2459 LCTNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCP 2518
Query: 152 -----MPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSV 206
C+D C C + C+ G K P T A +
Sbjct: 2519 RGYVLQEDGKTCKDLDECQTKQHNCQFL---CVNTLGGFTC--KCPPGFTQHHTACIDNN 2573
Query: 207 MCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENA 266
C S C C P G + C + + L+C D CD +C ++
Sbjct: 2574 ECGSQPSLCGAKGICQNTP-GSFSCECQRGFSLDATGLNCEDVDE-CDG-NHRC---QHG 2627
Query: 267 TTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGF 326
++L G +C CP GY +Q W C C + C A
Sbjct: 2628 CQNIL--------GGYRC----GCPQGY----IQHYQWNQCVDENE--CSNPNACGSASC 2669
Query: 327 --TCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSG 384
T + K C P+ S + C +V+ C SS C
Sbjct: 2670 YNTLGSYKCAC-------------PSGFSFDQFSSA-----CHDVNECSSSKNPCN---- 2707
Query: 385 EWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRG 419
+GC C CP GY V +G C G
Sbjct: 2708 -YGCSNTEGGYLCG-----CPPGYYRVGQGHCVSG 2736
Score = 37.7 bits (86), Expect = 0.030
Identities = 128/620 (20%), Positives = 183/620 (29%), Gaps = 187/620 (30%)
Query: 26 CPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCP 85
C C++ G+ Y C + PT + C + C+ T G+ C
Sbjct: 544 CTNGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNT-DGSFQCI- 601
Query: 86 FPEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC----CV 141
C GF + DG++C EC + C C+
Sbjct: 602 -------------CNAGFELTTDGKNCVDHD---------------ECTTTNMCLNGMCI 633
Query: 142 MVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNR--- 198
DGS+ C C+ P+G +C V C TP G + ++ + R
Sbjct: 634 NEDGSFKC-------ICKPGFVLAPNGRYCTDV-DECQTP-GICMNGHCINSEGSFRCDC 684
Query: 199 ----AVALSSSVMCPDARSRCPDGSTCCELPSGKYGCC--PMPNAT-----CCS------ 241
AV + V C D R STC K G C P P A CC+
Sbjct: 685 PPGLAVGMDGRV-CVDTHMR----STC--YGGIKKGVCVRPFPGAVTKSECCCANPDYGF 737
Query: 242 -DHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQ 300
+ CP + C S T D + + D ++ C +G C
Sbjct: 738 GEPCQPCPAKNSAE-FHGLCSSGVGITVD------GRDINECALDPDI-CANG--ICENL 787
Query: 301 SGAWGC-C-----PFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSL 354
G++ C C P C D C CD G C P +
Sbjct: 788 RGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCD--NGLCRNTP--------GSYSCTC 837
Query: 355 PDPQALKRDV-PCDNVSSC---PSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC 410
P + + C++++ C P + C+ G + C CS G C
Sbjct: 838 PPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNC-------ECSPGSKLSSTGLIC 890
Query: 411 V--AEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQH-TSCPVGQTCCPSLGGSWAC- 466
+ +G C + D C+ + + CC +LG +W
Sbjct: 891 IDSLKGTCWLNIQ-------------------DSRCEVNINGATLKSECCATLGAAWGSP 931
Query: 467 ---CQLPHA----------VCCEDRQHC------CPAGYTCNVKARSCEKEVVSAQPATF 507
C+L A V CED C CP G N K
Sbjct: 932 CERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSK---------------- 975
Query: 508 LARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRC-- 565
G EC EG C D R + + C H P FR
Sbjct: 976 -------GSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECI----HPVPGKFRMDA 1024
Query: 566 ------AARGTKCLRREAPR 579
AA GT+C E P+
Sbjct: 1025 CCCAVGAAWGTEC--EECPK 1042
Score = 34.3 bits (77), Expect = 0.33
Identities = 34/117 (29%), Positives = 43/117 (36%), Gaps = 20/117 (17%)
Query: 58 GGPC-----QVDAHCSAGHSCIFTVS---GTSSCCPFPEAVACGD------GHHC-CPRG 102
GG C + C AGH T C P G+ + C CPRG
Sbjct: 289 GGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETGECSNTVGSYFCVCPRG 348
Query: 103 FHCSADGRSCF-QRSGNNSVGAIQCPDSQFECPDFST---CCVMVDGSWGCCPMPQA 155
+ S DG C QR+G G + +Q E P T CC WG +P+A
Sbjct: 349 YVTSTDGSRCIDQRTGMCFSGLVNGRCAQ-ELPGRMTKMQCCCEPGRCWGIGTIPEA 404
Score = 32.3 bits (72), Expect = 1.3
Identities = 110/532 (20%), Positives = 161/532 (30%), Gaps = 116/532 (21%)
Query: 99 CPRGFHCSADGR------SCFQRSGNNSVGAIQCPDSQFEC---PDFSTCCVMVDGSWGC 149
CP+G++ S D R CF G G + C P++ + V+G C
Sbjct: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEY----MQVNGGHNC 1732
Query: 150 CPMPQASC--------CED--------RVHCCPH--GAFCDLVHTRCITPTGT---HPLA 188
M ++ C CE+ R+ CC + G + C TP GT +
Sbjct: 1733 MDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEPCPTP-GTADFKTIC 1791
Query: 189 KKLPA----QRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHL 244
+P T +AV + C + C +G ++ S + C P +D L
Sbjct: 1792 GNIPGFTFDIHTGKAVDIDE---CKEIPGICANGVCINQIGSFR---CECPTGFSYNDLL 1845
Query: 245 HCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAW 304
C C + C + NA ++ G +C+ C G+ +GA
Sbjct: 1846 LVCEDIDECSNGDNLC--QRNADC-------INSPGSYRCE----CAAGFKLS--PNGA- 1889
Query: 305 GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV 364
C D C C QG +Q H Q +
Sbjct: 1890 ----------CVDRNECLEIPNVCSHGLCVDLQGSYQ------CICHNGFKASQDQTMCM 1933
Query: 365 PCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVC-----CSDHQHCCPQGYTCVAEGQCQRG 419
D P + C+ T G + C P C D C G+C
Sbjct: 1934 DVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRC--F 1991
Query: 420 SEIVAGLEKMPARRASLSHPRDIGCDQHTSC-PVGQTC----CPSLGGSWACCQLPHAVC 474
+EI G K P C C + +C C +L GS+ C
Sbjct: 1992 NEI--GSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRC-------- 2041
Query: 475 CEDRQHCCPAGYTCNVKARSC-EKEVVSAQP--ATFLARSPHVGVKDVECGEGHFCHDNQ 531
CP GY VK+ +C + P F + + G C G DN
Sbjct: 2042 ------ICPPGY--EVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNG 2093
Query: 532 TCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAP 583
C D RQ + + G C P F C + W P
Sbjct: 2094 RRCFDTRQSFCFTNFENGKCSV------PKAFNTTKAKCCCSKMPGEGWGDP 2139
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 57.4 bits (137), Expect = 4e-08
Identities = 107/473 (22%), Positives = 148/473 (31%), Gaps = 94/473 (19%)
Query: 71 HSCIFTVSGTSSCCPFPEAVACGDGHHC-CPRGFHCSADGRSCFQRSGNNSVGAIQCPDS 129
H C G S+ C ++ G GH C CP F+ +DGR+C C S
Sbjct: 3292 HPCKVNNGGCSNLC----LLSPGGGHKCACPTNFYLGSDGRTCVSN----------CTAS 3337
Query: 130 QFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPL-- 187
QF C + C + W C D CP C +C T T+P
Sbjct: 3338 QFVCKN-DKC---IPFWWKCDTEDDCGDHSDEPPDCPEFK-CRPGQFQCSTGICTNPAFI 3392
Query: 188 -------AKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC--------C 232
+ V L S C + +RC G C +G+ C C
Sbjct: 3393 CDGDNDCQDNSDEANCDIHVCLPSQFKCTNT-NRCIPGIFRC---NGQDNCGDGEDERDC 3448
Query: 233 P----MPNATCCSDHLHCCPQDTVCD--------------LIQSKCLSKENATTDLLTKL 274
P PN CS C P+ VCD Q C E D +
Sbjct: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCI 3508
Query: 275 PAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGT 334
PA KCD E C DG + + C P+ C+++ C P + CD
Sbjct: 3509 PARW----KCDGEDDCGDGSDEPKEECDERTCEPYQFR--CKNN-RCVPGRWQCDYDNDC 3561
Query: 335 CEQGPHQVPWMEK-APAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGC---CP 390
+ + + + S + + + CD C S E C C
Sbjct: 3562 GDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADG-------SDEKDCTPRCD 3614
Query: 391 IPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVA---GLEKMPAR----RASLSHPRDIG 443
+ + C S H C P + C A+ C GS+ A G+ P +L P
Sbjct: 3615 MDQFQCKSGH--CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWK 3672
Query: 444 CDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCE 496
CD C P + VC +R C C R C+
Sbjct: 3673 CDGEDDCGDNSDENPE--------ECARFVCPPNRPFRCKNDRVCLWIGRQCD 3717
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/261 (22%), Positives = 82/261 (31%), Gaps = 35/261 (13%)
Query: 293 GYTCCRLQSGAWGC---CPFT----QAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWM 345
G CR+ +G GC C T Q C ED + D TC P VP
Sbjct: 803 GTNKCRVNNG--GCSSLCLATPGSRQCACAEDQV--------LDADGVTCLANPSYVPPP 852
Query: 346 EKAPAHLSLPDPQALKRDVPCDNVSSC-PSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCC 404
+ P + + + ++ CD + C +SD L CP C ++ C
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQH--TCPSDRFKC--ENNRCI 908
Query: 405 PQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTC-----CPS 459
P + C + C + E A P C P+ TC C
Sbjct: 909 PNRWLCDGDNDCGNSED-----ESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGD 963
Query: 460 LGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDV 519
A C P C Q C G N+ R C+ + + S
Sbjct: 964 RSDESASCAYP--TCFPLTQFTCNNGRCININWR-CDNDNDCGDNSDEAGCSHSCSSTQF 1020
Query: 520 ECGEGHFCHDNQTCCRDNRQG 540
+C G ++ TC DN G
Sbjct: 1021 KCNSGRCIPEHWTCDGDNDCG 1041
Score = 44.7 bits (104), Expect = 2e-04
Identities = 111/511 (21%), Positives = 155/511 (30%), Gaps = 104/511 (20%)
Query: 26 CPVACCLDPGGASYSCCRP-LLDKWPTTLSRHLGGP-------CQVDAHCSAGHSCI--- 74
C C PG +C +LD T L P CQ A CI
Sbjct: 814 CSSLCLATPGSRQCACAEDQVLDADGVTC---LANPSYVPPPQCQPGEFACANSRCIQER 870
Query: 75 FTVSGTSSC---------------CPFPEAVACGDGHHCCPRGFHCSAD---GRSCFQRS 116
+ G + C CP + C + + C P + C D G S +
Sbjct: 871 WKCDGDNDCLDNSDEAPALCHQHTCP-SDRFKC-ENNRCIPNRWLCDGDNDCGNS--EDE 926
Query: 117 GNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHT 176
N + A CP +QF C S C+ + SW C D C + L
Sbjct: 927 SNATCSARTCPPNQFSCA--SGRCIPI--SWTCDLDDDCGDRSDESASCAYPTCFPLTQF 982
Query: 177 RCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC---CP 233
C ++ C + RC + + C + S + GC C
Sbjct: 983 TC-------------------------NNGRCININWRCDNDNDCGD-NSDEAGCSHSCS 1016
Query: 234 MPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDG 293
C S C P+ CD + C + T T G D E C
Sbjct: 1017 STQFKCNSG--RCIPEHWTCD-GDNDCGDYSDETHANCTNQATRPPGGCHTD-EFQCRLD 1072
Query: 294 YTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCD-TQKGTCEQGPHQVPWMEKAPAHL 352
C L+ W C T + D C CD + K C+ + KA
Sbjct: 1073 GLCIPLR---WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCI---SKAWVCD 1126
Query: 353 SLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVC-----C---SDHQHCC 404
D + + C++++ P S C TS C P+ +C C SD C
Sbjct: 1127 GDNDCEDNSDEENCESLACRPPSHPCANNTS----VCLPPDKLCDGNDDCGDGSDEGELC 1182
Query: 405 PQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSW 464
Q + G C + G S ++G D HT C + C L S
Sbjct: 1183 DQ--CSLNNGGCSHNCSVAPG----EGIVCSCPLGMELGPDNHT-CQIQSYCAKHLKCSQ 1235
Query: 465 ACCQLPHAVCCEDRQHCCPAGYTCNVKARSC 495
C Q +V C C G+ SC
Sbjct: 1236 KCDQNKFSVKCS-----CYEGWVLEPDGESC 1261
Score = 43.1 bits (100), Expect = 7e-04
Identities = 104/469 (22%), Positives = 149/469 (31%), Gaps = 74/469 (15%)
Query: 71 HSCIFTVSGTSSCCPFPEAVACGDGHHC-CPRGFHCSADGRSCFQRSGNNSVGAIQCPDS 129
+ C G SS C +A C C ADG +C + + V QC
Sbjct: 805 NKCRVNNGGCSSLC-----LATPGSRQCACAEDQVLDADGVTCL--ANPSYVPPPQCQPG 857
Query: 130 QFECPDFSTCCVM----VDGSWGCCPMPQASCCEDRVHCCPHGAF-CDLVHTRCITPTGT 184
+F C + + C+ DG C + H CP F C+ + RCI P
Sbjct: 858 EFACAN--SRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCE--NNRCI-PNRW 912
Query: 185 HPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHL 244
+ + A S+ CP + C G C + + C + SD
Sbjct: 913 LCDGDNDCGNSEDESNATCSARTCPPNQFSCASGR-CIPI---SWTCDLDDDCGDRSDES 968
Query: 245 HCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAW 304
C T L Q C + + +CD + C D ++G
Sbjct: 969 ASCAYPTCFPLTQFTCNNGRCININW------------RCDNDNDCGDNSD----EAGCS 1012
Query: 305 GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLP------DPQ 358
C TQ C C P +TCD G + G + + P D
Sbjct: 1013 HSCSSTQFKCNSGR--CIPEHWTCD---GDNDCGDYSDETHANCTNQATRPPGGCHTDEF 1067
Query: 359 ALKRDVPCDNVSSCPSSDTCCQLTSGEWGC------CPIPEAVCCSDHQHCCPQGYTCVA 412
+ D C + DT C +S E C C C D C + + C
Sbjct: 1068 QCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDG 1127
Query: 413 EGQCQRGS--EIVAGLEKMP-----ARRASLSHPRDIGCDQHTSCPVG-------QTCCP 458
+ C+ S E L P A S+ P D CD + C G C
Sbjct: 1128 DNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSL 1187
Query: 459 SLGG-SWACCQLP--HAVC-CEDRQHCCPAGYTCNVKARSCEKEVVSAQ 503
+ GG S C P VC C P +TC +++ C K + +Q
Sbjct: 1188 NNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQS-YCAKHLKCSQ 1235
Score = 40.0 bits (92), Expect = 0.006
Identities = 68/327 (20%), Positives = 102/327 (31%), Gaps = 69/327 (21%)
Query: 292 DGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQK--GTCEQGPHQVPWMEKAP 349
DG TC C +Q VC D C P + CDT+ G P P + P
Sbjct: 3326 DGRTCV-------SNCTASQFVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRP 3376
Query: 350 AHLSLPDPQALKRDVPCDNVSSC---------------PSSDTCCQLT---------SGE 385
CD + C PS C +G+
Sbjct: 3377 GQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQ 3436
Query: 386 WGC--------CP----IPEAVCCSDHQHCCPQGYTCVAEGQCQRGS-------EIVAGL 426
C CP P CS + C P+ + C + C GS ++ G+
Sbjct: 3437 DNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGV 3496
Query: 427 EKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGY 486
++ + + P CD C G P C+ P+ C++ + C P +
Sbjct: 3497 DEFRCKDSGRCIPARWKCDGEDDCGDGSD-EPKEECDERTCE-PYQFRCKNNR-CVPGRW 3553
Query: 487 TC---NVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWAC 543
C N + ++E + +P + + C G + D C D C
Sbjct: 3554 QCDYDNDCGDNSDEESCTPRPCS----ESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Query: 544 ---CPYRQGVCCADRRHCCPAGFRCAA 567
C Q C + HC P +RC A
Sbjct: 3610 TPRCDMDQFQCKSG--HCIPLRWRCDA 3634
Score = 38.1 bits (87), Expect = 0.023
Identities = 50/228 (21%), Positives = 72/228 (31%), Gaps = 46/228 (20%)
Query: 365 PCDNVSSCPSSDTCCQLT------SGEWGC-------CPIPEAVCCSDHQHCCPQGYTCV 411
PC+ S C + C S E C CP+ C S C P +TC
Sbjct: 2659 PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR--CIPMSWTCD 2716
Query: 412 AEGQCQRGSEIVAGLEKMPARRASLSHPRDIG----CDQHTSCP---------VGQTCCP 458
E C+ G + + + + R I CD C G+TC P
Sbjct: 2717 KEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGP 2776
Query: 459 SLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKD 518
S S++C P C + C C A ++ + + ++
Sbjct: 2777 S---SFSC---PGTHVCVPERWLCDGDKDC---ADGADESIAAGCLYNSTCDDREFMCQN 2827
Query: 519 VECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCA 566
+C HF D+ C D C Y C P+ FRCA
Sbjct: 2828 RQCIPKHFVCDHDRDCADGSDESPECEYPT---------CGPSEFRCA 2866
Score = 34.3 bits (77), Expect = 0.33
Identities = 46/237 (19%), Positives = 69/237 (29%), Gaps = 82/237 (34%)
Query: 306 CCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVP 365
C P + C D I C G+ CD ++ C G + P +
Sbjct: 27 CSP--KQFACRDQITCISKGWRCDGER-DCPDGSDEAPEI-------------------- 63
Query: 366 CDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQ-CQRGSEIVA 424
CP +A C ++H C CV + C + +
Sbjct: 64 -----------------------CPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMD 100
Query: 425 GLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAV-----CCEDRQ 479
G ++ P R + +GC H C P+L G C + C+D
Sbjct: 101 GSDEGPHCRELQGNCSRLGCQHH--------CVPTLDGPTCYCNSSFQLQADGKTCKDFD 152
Query: 480 HC--------------------CPAGYTCNVKARSC--EKEVVSAQPATFLARSPHV 514
C C GY RSC + E V P +A S ++
Sbjct: 153 ECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNI 209
Score = 30.4 bits (67), Expect = 4.8
Identities = 31/122 (25%), Positives = 42/122 (34%), Gaps = 45/122 (36%)
Query: 55 RHLGGPCQVDA---HCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADGRS 111
R+ G C++D HC G +C + SG +C CP GF G
Sbjct: 4225 RYTGDKCELDQCWEHCRNGGTCAASPSGMPTCR--------------CPTGF----TGPK 4266
Query: 112 CFQR-----SGNNSVGAI-----------------QCPDSQFE--CPDFSTCCVMVDGSW 147
C Q+ NNS + +C Q C +F TC + DGS
Sbjct: 4267 CTQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQYRQCSGYCENFGTCQMAADGSR 4326
Query: 148 GC 149
C
Sbjct: 4327 QC 4328
Score = 30.0 bits (66), Expect = 6.3
Identities = 20/85 (23%), Positives = 26/85 (30%), Gaps = 28/85 (32%)
Query: 87 PEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGS 146
P+ AC D C +G+ C G CPD E P+
Sbjct: 29 PKQFACRDQITCISKGWRCD---------------GERDCPDGSDEAPEI---------- 63
Query: 147 WGCCPMPQASCCEDRVHCCPHGAFC 171
CP +A C+ H C C
Sbjct: 64 ---CPQSKAQRCQPNEHNCLGTELC 85
Score = 29.6 bits (65), Expect = 8.2
Identities = 24/91 (26%), Positives = 34/91 (37%), Gaps = 20/91 (21%)
Query: 260 CLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHI 319
C K+ A D +T + +CD E CPDG A CP ++A C+ +
Sbjct: 27 CSPKQFACRDQITCISKGW----RCDGERDCPDG------SDEAPEICPQSKAQRCQPNE 76
Query: 320 HCCPAGFTCDTQKGTC----------EQGPH 340
H C C C ++GPH
Sbjct: 77 HNCLGTELCVPMSRLCNGVQDCMDGSDEGPH 107
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 56.6 bits (135), Expect = 6e-08
Identities = 98/454 (21%), Positives = 149/454 (32%), Gaps = 92/454 (20%)
Query: 140 CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRA 199
C+ GS+ C P S +D C P G P A + PA ++ +
Sbjct: 620 CINTVGSYHCACFPGFSLQDDGRTCRPEGH-------------PPQPEAPQEPALKSEFS 666
Query: 200 VALSSSVMCPDAR-SRCPDGSTC---CELPSGKYGCCPMPNATCCSDHLHCCP-QDTVCD 254
S+++ P + + C D C C G C P +D + C + V D
Sbjct: 667 QVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTD 726
Query: 255 LIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVC 314
L C E+ +T+G C ++C GY L+ G C
Sbjct: 727 L--HTCSRGEHCV---------NTLGSFHCYKALTCEPGYA---LKDGE---CEDVDE-- 767
Query: 315 CEDHIHCCPAGFTCDTQKGT--CEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSC 372
C H C GF C KG+ C+ + L DP+ C +++ C
Sbjct: 768 CAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGF--------LQDPEG-----NCVDINEC 814
Query: 373 PS-SDTC-----CQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRG------S 420
S S+ C C T G + C P + C+ H G CV +C+ G
Sbjct: 815 TSLSEPCRPGFSCINTVGSYTCQRNP--LICARGYHASDDGTKCVDVNECETGVHRCGEG 872
Query: 421 EIVAGLEKMPARRASLSHPRDI---GCDQHTSC--PVGQTC---CPSLGGSWACCQLPHA 472
++ L RD GC C G+ C C + GS+ C
Sbjct: 873 QVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGF 932
Query: 473 VCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQT 532
+ D + C CE + S + A G C +G+ ++
Sbjct: 933 LLAADGKRC--------EDVNECEAQRCSQECANI------YGSYQCYCRQGYQLAEDGH 978
Query: 533 CCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCA 566
C D + C G+ C R P ++CA
Sbjct: 979 TCTDIDE----CAQGAGILCTFRCLNVPGSYQCA 1008
Score = 54.3 bits (129), Expect = 3e-07
Identities = 79/331 (23%), Positives = 105/331 (31%), Gaps = 95/331 (28%)
Query: 320 HC-CPAGFTCDTQKGTCEQGPHQVPWMEKAPAH----------------LSLPDPQALKR 362
HC C GF+ TC H P +AP L LP P K
Sbjct: 628 HCACFPGFSLQDDGRTCRPEGH--PPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKD 685
Query: 363 DVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEI 422
+ PC V S C G + + V C D C +T C RG
Sbjct: 686 NGPCKQVCSTVGGSAICSCFP---GYAIMADGVSCEDINECVTDLHT------CSRGEHC 736
Query: 423 VAGLEKMPARRASLSHP----RDIGCDQHTSCPVG-QTC-----CPSLGGSWAC------ 466
V L +A P +D C+ C +G TC C + GS+ C
Sbjct: 737 VNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRC 796
Query: 467 ----CQLPHAVC-----CEDRQHCCPAGYTC--NVKARSCEKEVVSAQPATFLARSPHV- 514
Q P C C C G++C V + +C++ + AR H
Sbjct: 797 MDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPL------ICARGYHAS 850
Query: 515 --GVKDVE----------CGEGHFCHD---NQTC--------------CRDNRQGWA--- 542
G K V+ CGEG CH+ + C C D + WA
Sbjct: 851 DDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPG 910
Query: 543 -CCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
C + R C +GF AA G +C
Sbjct: 911 RLCQHTCENTLGSYRCSCASGFLLAADGKRC 941
Score = 48.5 bits (114), Expect = 2e-05
Identities = 121/536 (22%), Positives = 174/536 (32%), Gaps = 115/536 (21%)
Query: 71 HSCIFTVSGTSSCCPFPEAVACGDGHHCCPRGFHCSADG------RSCFQRSGNNSVGAI 124
H CI TV G+ C FP DG C P G + +S F + +N++ +
Sbjct: 618 HLCINTV-GSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTI-PL 675
Query: 125 QCPDSQFECPDFSTC---CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHT----- 176
P C D C C V GS C P + D V C +HT
Sbjct: 676 PLPQPN-TCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGE 734
Query: 177 RCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTC-----CELPSGKYGC 231
C+ G+ K L + AL C D TC C+ G + C
Sbjct: 735 HCVNTLGSFHCYKALTCE---PGYALKDG-ECEDVDECAMGTHTCQPGFLCQNTKGSFYC 790
Query: 232 CPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME-VSC 290
C D P+ D+ ++C S + + +TVG C + C
Sbjct: 791 QARQR---CMDGFLQDPEGNCVDI--NECTSLSEPCRPGFSCI--NTVGSYTCQRNPLIC 843
Query: 291 PDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPA 350
GY C + CE +H C G C H +P +
Sbjct: 844 ARGY---HASDDGTKCVDVNE---CETGVHRCGEGQVC-----------HNLPGSYRCDC 886
Query: 351 HLSLPDPQALKRDV---PCDNVSSCPSS-----DTCCQLTSGEWGCCPIPEAVCCSDHQH 402
+RD C +V+ C +S C+ T G + C + +D +
Sbjct: 887 ------KAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKR 940
Query: 403 CCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG- 461
C V E + QR S+ A + + + + D HT + + C G
Sbjct: 941 C-----EDVNECEAQRCSQECANI--YGSYQCYCRQGYQLAEDGHTCTDIDE-CAQGAGI 992
Query: 462 -GSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDV- 519
++ C +P + C C GYT RSC KDV
Sbjct: 993 LCTFRCLNVPGSYQCA----CPEQGYTMTANGRSC---------------------KDVD 1027
Query: 520 ECGEG-HFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLR 574
EC G H C + +TC N QG C R CP + ++ TKC R
Sbjct: 1028 ECALGTHNCSEAETC--HNIQGSFRC----------LRFECPPNYVQVSK-TKCER 1070
Score = 38.1 bits (87), Expect = 0.023
Identities = 101/486 (20%), Positives = 151/486 (31%), Gaps = 104/486 (21%)
Query: 59 GPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVACGDGHHC-----CPRGFHCSADGRSCF 113
GPC+ CS TV G++ C FP DG C C H + G C
Sbjct: 687 GPCK--QVCS-------TVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCV 737
Query: 114 QRSGN-NSVGAIQCPD----SQFECPDFSTCCVMVDGSWGCCPMPQASCCEDRVHCCPHG 168
G+ + A+ C EC D C + G+ C P C++ G
Sbjct: 738 NTLGSFHCYKALTCEPGYALKDGECEDVDECAM---GTHTCQP---GFLCQN-----TKG 786
Query: 169 AFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGK 228
+F RC+ P + C C G +C G
Sbjct: 787 SFYCQARQRCMDGFLQDPEGNCVDINE------------CTSLSEPCRPGFSCIN-TVGS 833
Query: 229 YGCCPMPNATCCSDHLHCCPQDTVC-DLIQSKCLSKENATTDLLTKLPAHTVGDVKCDME 287
Y C N C+ H T C D+ + + + LP G +CD
Sbjct: 834 YTC--QRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLP----GSYRCD-- 885
Query: 288 VSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK 347
C G+ Q A+G C C TC+ G+
Sbjct: 886 --CKAGF-----QRDAFGRGCIDVNECWASPGRLCQ--HTCENTLGSYR--------CSC 928
Query: 348 APAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQG 407
A L D + C++V+ C + C Q + +G + C +Q G
Sbjct: 929 ASGFLLAADGKR------CEDVNEC-EAQRCSQECANIYGSY---QCYCRQGYQ-LAEDG 977
Query: 408 YTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACC 467
+TC +C +G+ I+ L+ P C CP G +
Sbjct: 978 HTCTDIDECAQGAGILCTFR-------CLNVPGSYQC-----------ACPEQGYTMTA- 1018
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC 527
+ C+D C + C+ +A +C S + F +V V +C E C
Sbjct: 1019 ---NGRSCKDVDECALGTHNCS-EAETCHNIQGSFRCLRFECPPNYVQVSKTKC-ERTTC 1073
Query: 528 HDNQTC 533
HD C
Sbjct: 1074 HDFLEC 1079
Score = 34.3 bits (77), Expect = 0.33
Identities = 30/129 (23%), Positives = 48/129 (37%), Gaps = 46/129 (35%)
Query: 454 QTCCPSLGGSWA-----CCQLPHA-----VCCEDRQHCCPAGYTCNVKARSCEKEVVSAQ 503
+TCC + G WA C ++P + VC ++HCC + ++ +SC V+ A+
Sbjct: 443 ETCCAA-GQQWAIDNDECLEIPESGTEDNVCRTAQRHCCVS----YLQEKSCMAGVLGAK 497
Query: 504 PATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGF 563
+ +TC ++ Y+Q CC CC G
Sbjct: 498 -------------------------EGETCGAEDNDSCGISLYKQ--CC----DCCGLGL 526
Query: 564 RCAARGTKC 572
R A G C
Sbjct: 527 RVRAEGQSC 535
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 149/683 (21%), Positives = 206/683 (30%), Gaps = 227/683 (33%)
Query: 20 CPDGQFCPV-ACCLDPGGASYSC-CRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTV 77
C +G C A C++ G SY C C+P ++ +T + CQ + + CI TV
Sbjct: 1812 CQNGPVCQRNAECINTAG-SYRCDCKPGY-RFTSTGQCNDRNECQEIPNICSHGQCIDTV 1869
Query: 78 SGTSSCCPFP----------------EAVACGDG--------HHC-CPRGFHCS-----A 107
C E ACG+G +C C GF S
Sbjct: 1870 GSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCI 1929
Query: 108 DGRSCFQRSGN--------NSVGAIQC---------PDSQFECPDFSTC----------- 139
D C +GN N+VG+ QC PD + C D + C
Sbjct: 1930 DVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGR-TCVDINECLLEPRKCAPGT 1988
Query: 140 CVMVDGSWGCCPMP----QASCCEDRVHCCPHGAFCDLVHT-------RCITPTGTHPLA 188
C +DGS+ C P Q CED C C L +C+ P G
Sbjct: 1989 CQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEG----- 2043
Query: 189 KKLPAQRTNRAVALSSSVM-CPDAR-SRCP---DGSTCCELPS---GKYGCCPMPNATCC 240
+LSSS C D R S C +G C S K CC
Sbjct: 2044 -----------FSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGW 2092
Query: 241 SDHLHCCPQDT------VCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGY 294
D CP + +C + +++ D+ +C C G
Sbjct: 2093 GDPCELCPTEPDEAFRQICPYGSGIIVGPDDSAVDM-----------DECKEPDVCKHGQ 2141
Query: 295 TCCRLQSGAWGC-CPFTQAVC---CEDHIHCC---PAGF-TCDTQKG----TCEQGPHQV 342
C G++ C CPF + C D C P G TC G TCE+G
Sbjct: 2142 --CINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPG 2199
Query: 343 PWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQL----TSGEWGCCPIPEAVCCS 398
P M C++++ C + C T G + C
Sbjct: 2200 PMMT-------------------CEDINECAQNPLLCAFRCVNTYGSYECK--------- 2231
Query: 399 DHQHCCPQGYT-------CVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCP 451
CP GY C E +C+ G C
Sbjct: 2232 -----CPVGYVLREDRRMCKDEDECEEGKH---------------------------DCT 2259
Query: 452 VGQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARS 511
Q C +L G++ C P D + C C K CE ++
Sbjct: 2260 EKQMECKNLIGTYMCICGPGYQRRPDGEGCVDEN-ECQTKPGICENGRCLNTRGSYTC-- 2316
Query: 512 PHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVC--------CADRRHCCPAGF 563
EC +G NQ C DNR+G+ Q +C + CC G
Sbjct: 2317 --------ECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGG 2368
Query: 564 R--------CAARGTKCLRREAP 578
R C +GT ++ P
Sbjct: 2369 RGWGPHCEICPFQGTVAFKKLCP 2391
Score = 51.2 bits (121), Expect = 3e-06
Identities = 127/566 (22%), Positives = 170/566 (30%), Gaps = 129/566 (22%)
Query: 22 DGQFCPVACCLDPGGASYSC-CRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGT 80
D C C + G SY C C P P + C++ AH C+ + G
Sbjct: 1120 DPLLCRGGVCHNTEG-SYRCECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLI-GK 1177
Query: 81 SSCCPFPEAVACGDGHHCCPRGFHCSADGRSCFQRSGN------NSVGAIQC-------- 126
C AC G+H P C D C +G NS G+ +C
Sbjct: 1178 YQC-------ACNPGYHSTPDRLFC-VDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL 1229
Query: 127 -PDSQFECPDFSTC-----------CVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLV 174
PD Q C D C C + G + C ED C CDL
Sbjct: 1230 MPD-QRSCTDIDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNE-CDLN 1287
Query: 175 HTRCITPT-----GTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKY 229
C++ T G+ + + C C + C +G +
Sbjct: 1288 PNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNT-AGSF 1346
Query: 230 GCCPMPN-----ATC-----CSDHLHCCPQDTVCDLIQS--KCLSKENATTDLLTKLPA- 276
C P C CS+ H C Q C +CL KE T D T
Sbjct: 1347 KCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLD 1406
Query: 277 ------HTVGDVKCDMEVSCPDGYTC-CRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCD 329
+ G+ +C ++ P GY C C + G P CED C
Sbjct: 1407 ECSENLNLCGNGQC---LNAPGGYRCECDM-----GFVPSADGKACEDIDECSLPNICVF 1458
Query: 330 TQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC----CQLTSGE 385
GTC H +P + + + + + C +V+ C TC C T G
Sbjct: 1459 ---GTC----HNLPGLFRCECEIGY---ELDRSGGNCTDVNECLDPTTCISGNCVNTPGS 1508
Query: 386 WGC-CPI-----PEAVCCSDHQ--HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLS 437
+ C CP P V C D + +C G +EI G+ K SL
Sbjct: 1509 YICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCC-CSLG 1567
Query: 438 HPRDIGCDQHTSCPVGQTC-----CPSLGGSWACCQLPHAVCCEDRQHC----------- 481
C+ CP T CP G P V ED C
Sbjct: 1568 KAWGTPCEM---CPAVNTSEYKILCP---GGEGFRPNPITVILEDIDECQELPGLCQGGK 1621
Query: 482 -----------CPAGYTCNVKARSCE 496
CP GY N R C+
Sbjct: 1622 CINTFGSFQCRCPTGYYLNEDTRVCD 1647
Score = 49.7 bits (117), Expect = 8e-06
Identities = 133/644 (20%), Positives = 189/644 (29%), Gaps = 162/644 (25%)
Query: 30 CCLDPGGASYS--CCRPLLDKW--PTTLSRHLGGPCQVDAHCSAGHSCIFTVSGT----- 80
C ++ GA+ CC L W P TL CQVD C G+S + GT
Sbjct: 862 CEININGATLKSQCCSSLGAAWGSPCTL-------CQVDPICGKGYS---RIKGTQCEDI 911
Query: 81 SSCCPFPEAVACG------DGHHC-CPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFEC 133
C FP G C CP G A GR C ++ D +
Sbjct: 912 DECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLDIRLETCF--LRYEDEECTL 969
Query: 134 P-----DFSTCCVMVDGSWGC-----CPMPQASCCEDRVHCCPHGA-------------F 170
P CC V +WG CPM E+ CP G F
Sbjct: 970 PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEE---LCPRGPGFATKEITNGKPFF 1026
Query: 171 CDLVHTRCITPTGTHPLAKKLPAQ---RTNRAVALSSSVMCPDARSRCPDGSTCCELPS- 226
D+ + I TH + R + AL S C D C P
Sbjct: 1027 KDINECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSE------ERNCTDIDECRISPDL 1080
Query: 227 -GKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSK-CLSKENATTDLLT---KLPAHTVGD 281
G+ C P C C + + K C+ + D L + +T G
Sbjct: 1081 CGRGQCVNTPGDFECK-----CDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGS 1135
Query: 282 VKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAG---------------- 325
+C+ CP G+ +L C + CE H CP G
Sbjct: 1136 YRCE----CPPGH---QLSPNISACIDINE---CELSAHLCPNGRCVNLIGKYQCACNPG 1185
Query: 326 -------------FTCDTQKGTCE------QGPHQVPWMEKAPAHLSLPDPQALKRDVPC 366
C G CE +G ++ P +PD ++ C
Sbjct: 1186 YHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQ---PGFALMPDQRS------C 1236
Query: 367 DNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGL 426
++ C + C G+ P C D TCV +C I
Sbjct: 1237 TDIDECEDNPNICD--GGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSG 1294
Query: 427 EKMPARRASLSH--------PRDIGCDQHTSCPVG------QTCCPSLGGSWACCQLP-- 470
+ + + H GC C +G C + GS+ C P
Sbjct: 1295 TCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGW 1354
Query: 471 --HAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFCH 528
+ C D C + C+ A C+ + S + L + + G C + C
Sbjct: 1355 IGDGIKCTDLDECSNGTHMCSQHA-DCKNTMGSYR---CLCKEGYTG-DGFTCTDLDECS 1409
Query: 529 DNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKC 572
+N C + + C G C C GF +A G C
Sbjct: 1410 ENLNLCGNGQ----CLNAPGGYRCE-----CDMGFVPSADGKAC 1444
Score = 48.9 bits (115), Expect = 1e-05
Identities = 121/533 (22%), Positives = 172/533 (32%), Gaps = 122/533 (22%)
Query: 93 GDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC----CVMVDGSWG 148
G H C GFH + DG++C + EC + C C+ DGS+
Sbjct: 551 GSFHCVCNAGFHVTRDGKNC---------------EDMDECSIRNMCLNGMCINEDGSFK 595
Query: 149 CCPMPQASCCEDRVHC-----CPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALS 203
C P D +C C C ++ RC+ G++ + P AV L
Sbjct: 596 CICKPGFQLASDGRYCKDINECETPGIC--MNGRCVNTDGSY-RCECFP----GLAVGLD 648
Query: 204 SSVMCPDA--RSRCPDG---STCCELPSG---KYGCCPMPNATCCSDHLHCCPQDTVCDL 255
V C D RS C G C + G K CC + CP +
Sbjct: 649 GRV-CVDTHMRSTCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAE- 706
Query: 256 IQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGC-CPFTQAV- 313
Q+ C S T+ + + D ++ CP+G C G + C C V
Sbjct: 707 YQALCSSGPGMTS------AGSDINECALDPDI-CPNG--ICENLRGTYKCICNSGYEVD 757
Query: 314 ----CCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDV-PCDN 368
C D C CD G C P + P K D+ C++
Sbjct: 758 STGKNCVDINECVLNSLLCD--NGQCRNTPGSFV--------CTCPKGFIYKPDLKTCED 807
Query: 369 VSSCPSS---DTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCV--AEGQCQRGSEIV 423
+ C SS + C+ + G + C CS P C+ +G C + ++
Sbjct: 808 IDECESSPCINGVCKNSPGSFIC-------ECSSESTLDPTKTICIETIKGTCWQ--TVI 858
Query: 424 AGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCCP 483
G ++ A+L CC SLG +W P +C D C
Sbjct: 859 DGRCEININGATLK----------------SQCCSSLGAAWGS---PCTLCQVD--PICG 897
Query: 484 AGYTCNVKARSCEK----EVVSAQPATFLARSPHVGVKDVECGEGHFCHDNQTCCRDNRQ 539
GY+ +K CE EV L + K +C G C D R
Sbjct: 898 KGYS-RIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFK-CQCPSGMTLDATGRICLDIRL 955
Query: 540 GWACCPYRQGVCCAD--RRH-----CCPAGFRCAARGT----KCLRREAPRWD 581
Y C RH CC G AA GT +C R P ++
Sbjct: 956 ETCFLRYEDEECTLPIAGRHRMDACCCSVG---AAWGTEECEECPMRNTPEYE 1005
Score = 46.2 bits (108), Expect = 8e-05
Identities = 115/543 (21%), Positives = 162/543 (29%), Gaps = 111/543 (20%)
Query: 92 CGDGHHC-CPRGFHCSAD-GRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGC 149
CG G P F C D G N + +C C C +GS+ C
Sbjct: 1081 CGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCR--GGVCHNTEGSYRC 1138
Query: 150 -CP-----MPQASCCED------RVHCCPHGAFCDLV-HTRCITPTGTHPLAKKLPAQRT 196
CP P S C D H CP+G +L+ +C G H +L
Sbjct: 1139 ECPPGHQLSPNISACIDINECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDI 1198
Query: 197 NRAVALSSS--------------------VMCPDARS-----RCP------DGSTCCELP 225
+ ++ + PD RS C DG C +P
Sbjct: 1199 DECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIP 1258
Query: 226 SGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCD 285
G+Y C + S+ + C CDL + CLS T + K
Sbjct: 1259 -GEYRCL-CYDGFMASEDMKTCVDVNECDLNPNICLS--------------GTCENTKGS 1302
Query: 286 MEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGT--CEQGPHQVP 343
C GY+ + G GC + CE H C C G+ C P
Sbjct: 1303 FICHCDMGYSG---KKGKTGCTDINE---CEIGAHNCGKHAVCTNTAGSFKCSCSP---G 1353
Query: 344 WMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGC-CP---IPEAVCCSD 399
W+ L + C N + S C+ T G + C C + C+D
Sbjct: 1354 WIGDGIKCTDLDE---------CSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTD 1404
Query: 400 HQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTC--- 456
C C GQC G + + C+ C + C
Sbjct: 1405 LDECSENLNLC-GNGQCLN----APGGYRCECDMGFVPSADGKACEDIDECSLPNICVFG 1459
Query: 457 -CPSLGGSWAC-CQLPHAV-----CCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLA 509
C +L G + C C++ + + C D C + + + P F
Sbjct: 1460 TCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFEL 1519
Query: 510 RSPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
VG D G C+ + DN G C GV + CC G A G
Sbjct: 1520 NPTRVGCVDTRSGN---CYLDIRPRGDN--GDTACSNEIGVGVSKASCCCSLG---KAWG 1571
Query: 570 TKC 572
T C
Sbjct: 1572 TPC 1574
Score = 46.2 bits (108), Expect = 8e-05
Identities = 119/586 (20%), Positives = 171/586 (29%), Gaps = 137/586 (23%)
Query: 14 LVAGTRCPDGQFCPVA------CCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHC 67
++AG C D C V C + G C + P + Q C
Sbjct: 2158 ILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLC 2217
Query: 68 SAGHSCIFTVSGTSSCCPFPEAVA-----CGDGHHCCPRGFHCSADGRSCFQRSGNNSVG 122
+ C+ T CP + C D C C+ C N +G
Sbjct: 2218 A--FRCVNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDCTEKQMEC-----KNLIG 2270
Query: 123 AIQC---------PDSQFECPDFSTC-----------CVMVDGSWGC-------CPMPQA 155
C PD + C D + C C+ GS+ C Q
Sbjct: 2271 TYMCICGPGYQRRPDGE-GCVDENECQTKPGICENGRCLNTRGSYTCECNDGFTASPNQD 2329
Query: 156 SCCEDRVHCCPHGAFCDLVHTRC-ITPTGTHPLAKK----------------LPAQRTNR 198
C ++R C F +++ C I + +P+ K P Q T
Sbjct: 2330 ECLDNREGYC----FTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGT-- 2383
Query: 199 AVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDH--LHC-CPQDTVCDL 255
++ +CP R +G+ E C N C +D HC C D+
Sbjct: 2384 ---VAFKKLCPHGRGFMTNGADIDECKVIHDVC---RNGECVNDRGSYHCICKTGYTPDI 2437
Query: 256 IQSKC--LSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAV 313
+ C L++ N + +T G +C SCP GY LQ C +
Sbjct: 2438 TGTSCVDLNECNQAPKPCNFICKNTEGSYQC----SCPKGYI---LQEDGRSCKDLDE-- 2488
Query: 314 CCEDHIHCCP-------AGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPC 366
C H C GFTC G + H S D D+
Sbjct: 2489 -CATKQHNCQFLCVNTIGGFTCKCPPGFTQH-------------HTSCIDNNECTSDI-- 2532
Query: 367 DNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGL 426
+ S CQ T G + C C C +CQ G + + G
Sbjct: 2533 ----NLCGSKGICQNTPGSF-TCECQRGFSLDQTGSSCEDVDECEGNHRCQHGCQNIIGG 2587
Query: 427 EKMPARRASLSHPRDIGCDQHTSCPVGQTC----CPSLGGSWACCQLPHAVCCEDRQHCC 482
+ + L H + C C C C + GS+ C C
Sbjct: 2588 YRCSCPQGYLQHYQWNQCVDENECLSAHICGGASCHNTLGSYKC--------------MC 2633
Query: 483 PAGYTCNVKARSCE--KEVVSAQPATFLARSPHVGVKDVECGEGHF 526
PAG+ + C+ E SAQ S G C G+F
Sbjct: 2634 PAGFQYEQFSGGCQDINECGSAQAPCSYGCSNTEGGYLCGCPPGYF 2679
Score = 43.9 bits (102), Expect = 4e-04
Identities = 65/273 (23%), Positives = 96/273 (35%), Gaps = 49/273 (17%)
Query: 320 HCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCC 379
H C GF TC G ++ H + + C N SC SD C
Sbjct: 87 HSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQHCN----------IRCMNGGSC--SDDHC 134
Query: 380 QLTSGEWGC-CPIPEAVCCSDHQHCCPQGYTCVAEGQCQ-----RGSEIVAGLEKMPARR 433
G G C P VC S C G CVA +C G + P
Sbjct: 135 LCQKGYIGTHCGQP--VCESG----CLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFT 188
Query: 434 ASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWAC-CQLPHAVCCEDRQHCCPAGYTCNVKA 492
+S+ G C CC ++G +W C++ C + H C G+ N++
Sbjct: 189 V-ISNQMCQGQLSGIVC-TKTLCCATVGRAWGHPCEM-----CPAQPHPCRRGFIPNIRT 241
Query: 493 RSCEKEVVSAQPATFLARSPH----VGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQ 548
+C+ +V Q L + + VG + +C GH ++ C D + C
Sbjct: 242 GACQ-DVDECQAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDIDE----CSTIP 296
Query: 549 GVC-------CADRRHC-CPAGFRCAARGTKCL 573
G+C C CP GF + GT+C+
Sbjct: 297 GICEGGECTNTVSSYFCKCPPGFYTSPDGTRCI 329
Score = 39.3 bits (90), Expect = 0.010
Identities = 68/339 (20%), Positives = 100/339 (29%), Gaps = 115/339 (33%)
Query: 99 CPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGC-CP---MPQ 154
CP+G+ DGRSC +C Q C CV G + C CP
Sbjct: 2470 CPKGYILQEDGRSCKDLD--------ECATKQHNC---QFLCVNTIGGFTCKCPPGFTQH 2518
Query: 155 ASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRT---NRAVALSSSVMCPDA 211
+ C D C T I G+ + + P T R +L +
Sbjct: 2519 HTSCIDNNEC-----------TSDINLCGSKGICQNTPGSFTCECQRGFSLDQT------ 2561
Query: 212 RSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLL 271
S C D C ++GC + CS CPQ + ++C+ +
Sbjct: 2562 GSSCEDVDECEGNHRCQHGCQNIIGGYRCS-----CPQGYLQHYQWNQCVDENEC----- 2611
Query: 272 TKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQ 331
L AH G C + G++ C CPAGF +
Sbjct: 2612 --LSAHICGGASCHNTL-------------GSYKCM--------------CPAGFQYEQF 2642
Query: 332 KGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPI 391
G C+ +++ C S+ C +GC
Sbjct: 2643 SGGCQ-------------------------------DINECGSAQAPCS-----YGCSNT 2666
Query: 392 PEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMP 430
C CP GY + +G C G + G + P
Sbjct: 2667 EGGYLCG-----CPPGYFRIGQGHCVSGMGMGRGNPEPP 2700
Score = 37.7 bits (86), Expect = 0.030
Identities = 123/588 (20%), Positives = 177/588 (30%), Gaps = 135/588 (22%)
Query: 31 CLDPGGASYSC----CRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPF 86
CL P G S S C+ L + ++ GG C S HS CC
Sbjct: 2038 CLCPEGFSLSSSGRRCQDL--RMSYCYAKFEGGKCSSPK--SRNHS-------KQECCCA 2086
Query: 87 PEAVACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQF----ECPDFSTC--- 139
+ GD CP + F++ G I PD EC + C
Sbjct: 2087 LKGEGWGDPCELCP------TEPDEAFRQICPYGSGIIVGPDDSAVDMDECKEPDVCKHG 2140
Query: 140 -CVMVDGSWGC-CPMPQASC---CEDRVHC-----CPHGAFCDLVHT-RCITPTGTHPLA 188
C+ DGS+ C CP C D C C +G +++ C G P
Sbjct: 2141 QCINTDGSYRCECPFGYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEP-- 2198
Query: 189 KKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGC--CPMPNATCCSDHLHC 246
+ C D + C YG C P +
Sbjct: 2199 --------------GPMMTCEDINECAQNPLLCAFRCVNTYGSYECKCPVGYVLREDRRM 2244
Query: 247 CPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGC 306
C + C+ + C K+ +L +G C C GY R G GC
Sbjct: 2245 CKDEDECEEGKHDCTEKQMECKNL--------IGTYMC----ICGPGYQ--RRPDGE-GC 2289
Query: 307 -----CPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALK 361
C +C +TC+ G P+Q ++ + Q +
Sbjct: 2290 VDENECQTKPGICENGRCLNTRGSYTCECNDGFTAS-PNQDECLDNREGYCFTEVLQNMC 2348
Query: 362 RDVPCDNVSSCPSSDTCCQLTSGEWG----CCPIPEAVCCSDHQHCCPQGYTCVAEGQCQ 417
+ + N + S+ CC G WG CP V + CP G + G
Sbjct: 2349 Q-IGSSNRNPVTKSECCCDGGRG-WGPHCEICPFQGTVA---FKKLCPHGRGFMTNGADI 2403
Query: 418 RGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWA-----CCQLP-- 470
+++ + R + R H C G T P + G+ C Q P
Sbjct: 2404 DECKVIHDV----CRNGECVNDRG---SYHCICKTGYT--PDITGTSCVDLNECNQAPKP 2454
Query: 471 -HAVC--CEDRQHC-CPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDV-ECGEGH 525
+ +C E C CP GY RSC KD+ EC
Sbjct: 2455 CNFICKNTEGSYQCSCPKGYILQEDGRSC---------------------KDLDECATKQ 2493
Query: 526 FCHDNQTCCRDNRQGWAC-CP---YRQGVCCADRRHCCPAGFRCAARG 569
H+ Q C + G+ C CP + C D C C ++G
Sbjct: 2494 --HNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKG 2539
>gi|63053512 keratin associated protein 10-1 [Homo sapiens]
Length = 282
Score = 54.7 bits (130), Expect = 2e-07
Identities = 76/284 (26%), Positives = 96/284 (33%), Gaps = 67/284 (23%)
Query: 15 VAGTRCPDG---QFCPVACCLDPGGASYSCCRPL--LDKWPTTLSRHLG---------GP 60
V + C D CP +CC +P + SCC P L T +SR P
Sbjct: 8 VCSSACSDSWQVDACPESCC-EPHCCALSCCAPAPCLTLVCTPVSRVSSPCCQAACEPSP 66
Query: 61 CQVDAHCSAGHSCIFTVSGTSSCC---PFPEAVA---CGDGHHCCPRGFHCSADGRSCFQ 114
CQ S SC S +CC P +A C C P CS D SC Q
Sbjct: 67 CQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCLPT---CSKDSSSCCQ 123
Query: 115 RSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCC-PMPQA-SCCEDRVHCCP----HG 168
+S S C S + +CCV V CC P+ +C ED CC H
Sbjct: 124 QS---SCQPTCCASSSSQ----QSCCVPV-----CCKPVCYVPTCSEDSSSCCQQSSCHP 171
Query: 169 AFCDL--VHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTC----- 221
A C C P P+ K + +C A + C S+C
Sbjct: 172 ACCTSSPCQQACCVPVRCKPVCCK----------PICCVPVCSGASTSCCQQSSCQPACC 221
Query: 222 ---CELPSGKYG--CCPMPNATCCSDHLHCCPQDTVCDLIQSKC 260
C PS C P+ CC CC + C Q+ C
Sbjct: 222 TTSCCRPSSSVSLLCRPVCRPACCMPVSSCCAPASSC---QASC 262
Score = 53.1 bits (126), Expect = 7e-07
Identities = 73/297 (24%), Positives = 99/297 (33%), Gaps = 70/297 (23%)
Query: 296 CCRLQSGAW--GCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLS 353
C S +W CP + CCE H CC +C C P + + + +S
Sbjct: 9 CSSACSDSWQVDACPES---CCEPH--CC--ALSC------CAPAPC-LTLVCTPVSRVS 54
Query: 354 LPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCC---PIPEA----VCC--------- 397
P QA PC + + + +CCQ +S + CC P +A VCC
Sbjct: 55 SPCCQAACEPSPCQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCLPTC 114
Query: 398 -SDHQHCCPQGY---TCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVG 453
D CC Q TC A Q+ + + P C Q +SC
Sbjct: 115 SKDSSSCCQQSSCQPTCCASSSSQQSCCVPVCCK--PVCYVPTCSEDSSSCCQQSSC--H 170
Query: 454 QTCCPSLGGSWACCQLP---HAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLAR 510
CC S ACC +P VCC + CC C+ + SC ++ S QPA
Sbjct: 171 PACCTSSPCQQACC-VPVRCKPVCC--KPICCVP--VCSGASTSCCQQ-SSCQPA----- 219
Query: 511 SPHVGVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAA 567
C C + C P + CC CC C A
Sbjct: 220 ----------------CCTTSCCRPSSSVSLLCRPVCRPACCMPVSSCCAPASSCQA 260
Score = 46.2 bits (108), Expect = 8e-05
Identities = 85/351 (24%), Positives = 107/351 (30%), Gaps = 86/351 (24%)
Query: 137 STCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRT 196
S C SW P+ SCCE HCC A C+T T P R
Sbjct: 7 SVCSSACSDSWQVDACPE-SCCEP--HCC---ALSCCAPAPCLTLVCT-------PVSRV 53
Query: 197 NRAVALSSSVMCPDARSRCPDGST--CCELPSGKYGCCPM-PNATCCSDHLHCCPQDTVC 253
+ ++ P +S C T CC+ S + CC P C + C P VC
Sbjct: 54 SSPCCQAACEPSP-CQSGCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKP---VC 109
Query: 254 DLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAV 313
CL P + C + SC TCC S CC V
Sbjct: 110 ------CL-------------PTCSKDSSSCCQQSSCQP--TCCASSSSQQSCCV---PV 145
Query: 314 CCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCP 373
CC+ + TC +C Q P S P QA V C V
Sbjct: 146 CCKPVCYVP----TCSEDSSSCCQQSSCHP-----ACCTSSPCQQACCVPVRCKPV---- 192
Query: 374 SSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGY---TCVAEGQCQRGSEIVAGLEKMP 430
CC+ CC +P VC CC Q C C+ S +
Sbjct: 193 ----CCKPI-----CC-VP--VCSGASTSCCQQSSCQPACCTTSCCRPSSSV-------- 232
Query: 431 ARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHC 481
+ L P C PV C P+ +CC+ V R C
Sbjct: 233 ---SLLCRPV---CRPACCMPVSSCCAPASSCQASCCRPASCVSLLCRPAC 277
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 54.3 bits (129), Expect = 3e-07
Identities = 87/350 (24%), Positives = 117/350 (33%), Gaps = 59/350 (16%)
Query: 236 NATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDV-KCDMEVSCPDGY 294
N C C D D K+ T H + + KCD E CPDG
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
Query: 295 -----TCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK-A 348
TC + CP + C C PA + CD +K CE G + A
Sbjct: 116 DESEATCTKQ------VCPAEKLSCGPTSHKCVPASWRCDGEK-DCEGGADEAGCATLCA 168
Query: 349 PAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGC----CPIPEAVCCSDHQHCC 404
P + L CD C S E GC C E C D C
Sbjct: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDG-------SDERGCADPACGPREFRCGGDGGGAC 221
Query: 405 -PQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGS 463
P+ + C + C+ S+ A L P A+ S P +C G+ C LG
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGAT-SAPAACATASQFACRSGE--CVHLG-- 276
Query: 464 WACCQLPHAVCCEDR--QHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVEC 521
W C C+D+ + CP G +C + T + H ++ +C
Sbjct: 277 WRC---DGDRDCKDKSDEADCPLG--------TCRGDEFQCGDGTCVLAIKHCN-QEQDC 324
Query: 522 GEGHFCHDNQTCCRDNRQGWACCPYRQGVC---CADRR---HC-CPAGFR 564
+G D C QG C + G C C D + C CPAGF+
Sbjct: 325 PDG---SDEAGCL----QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 367
Score = 40.8 bits (94), Expect = 0.004
Identities = 70/291 (24%), Positives = 90/291 (30%), Gaps = 44/291 (15%)
Query: 210 DARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTD 269
D CPDGS E K CP +C C P CD + + A
Sbjct: 106 DGEEECPDGSDESEATCTKQ-VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 270 LLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC-CPAGFTC 328
L G+ C V DG C S GC C C G C
Sbjct: 165 TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC---ADPACGPREFRCGGDGGGAC 221
Query: 329 DTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVS--SCPSSDTCCQLTSGEW 386
++ C++ ++A P P A C S +C S + C L W
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHL---GW 277
Query: 387 GCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ 446
C + SD CP G E QC G+ ++A + H C+Q
Sbjct: 278 RCDGDRDCKDKSDEAD-CPLGTCRGDEFQCGDGTCVLA-----------IKH-----CNQ 320
Query: 447 HTSCPVG----------QTCCPSLGG-SWACCQLPHAVCCEDRQHCCPAGY 486
CP G C + GG S C L C CPAG+
Sbjct: 321 EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC-----TCPAGF 366
Score = 37.7 bits (86), Expect = 0.030
Identities = 82/346 (23%), Positives = 109/346 (31%), Gaps = 80/346 (23%)
Query: 22 DGQFCPVACCLDPGGASYSCCRP--LLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSG 79
D CP C D + ++C + ++W C + C G S +
Sbjct: 77 DEDDCPKKTCAD---SDFTCDNGHCIHERWK----------CDGEEECPDG-SDESEATC 122
Query: 80 TSSCCPFPEAVACGD-GHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFS- 137
T CP E ++CG H C P + C DG + + + A C +F+C + S
Sbjct: 123 TKQVCP-AEKLSCGPTSHKCVPASWRC--DGEKDCEGGADEAGCATLCAPHEFQCGNRSC 179
Query: 138 -TCCVMVDGSWGC--------CPMPQASCCEDRV------HCCPHGAFCDL--------- 173
+ DG C C P E R C P CD
Sbjct: 180 LAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSD 239
Query: 174 -VHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCC 232
C P P A PA + S C RC DG C+ S + C
Sbjct: 240 EAAELCGRP---GPGATSAPAACATASQFACRSGECVHLGWRC-DGDRDCKDKSDEADC- 294
Query: 233 PMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPD 292
P TC D C D C L C +++ E C
Sbjct: 295 --PLGTCRGDEFQC--GDGTCVLAIKHCNQEQDCPDG---------------SDEAGCLQ 335
Query: 293 GYTCCRLQSGAWGCCPFTQAVCCEDHI--HC-CPAGFTCDTQKGTC 335
G C +G GC +C + I C CPAGF QK TC
Sbjct: 336 GLNECLHNNG--GC----SHICTDLKIGFECTCPAGFQLLDQK-TC 374
Score = 31.6 bits (70), Expect = 2.2
Identities = 30/123 (24%), Positives = 43/123 (34%), Gaps = 18/123 (14%)
Query: 458 PSLGGSWAC--CQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVG 515
P LGG C+ C +R C P+ + C+ + P A S
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADS---- 89
Query: 516 VKDVECGEGHFCHDNQTC-----CRDNR-QGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
D C GH H+ C C D + A C + VC A++ C P +C
Sbjct: 90 --DFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ--VCPAEKLSCGPTSHKCVPAS 145
Query: 570 TKC 572
+C
Sbjct: 146 WRC 148
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 54.3 bits (129), Expect = 3e-07
Identities = 87/350 (24%), Positives = 117/350 (33%), Gaps = 59/350 (16%)
Query: 236 NATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDV-KCDMEVSCPDGY 294
N C C D D K+ T H + + KCD E CPDG
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGS 115
Query: 295 -----TCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEK-A 348
TC + CP + C C PA + CD +K CE G + A
Sbjct: 116 DESEATCTKQ------VCPAEKLSCGPTSHKCVPASWRCDGEK-DCEGGADEAGCATLCA 168
Query: 349 PAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGC----CPIPEAVCCSDHQHCC 404
P + L CD C S E GC C E C D C
Sbjct: 169 PHEFQCGNRSCLAAVFVCDGDDDCGDG-------SDERGCADPACGPREFRCGGDGGGAC 221
Query: 405 -PQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGS 463
P+ + C + C+ S+ A L P A+ S P +C G+ C LG
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGAT-SAPAACATASQFACRSGE--CVHLG-- 276
Query: 464 WACCQLPHAVCCEDR--QHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVEC 521
W C C+D+ + CP G +C + T + H ++ +C
Sbjct: 277 WRC---DGDRDCKDKSDEADCPLG--------TCRGDEFQCGDGTCVLAIKHCN-QEQDC 324
Query: 522 GEGHFCHDNQTCCRDNRQGWACCPYRQGVC---CADRR---HC-CPAGFR 564
+G D C QG C + G C C D + C CPAGF+
Sbjct: 325 PDG---SDEAGCL----QGLNECLHNNGGCSHICTDLKIGFECTCPAGFQ 367
Score = 40.8 bits (94), Expect = 0.004
Identities = 70/291 (24%), Positives = 90/291 (30%), Gaps = 44/291 (15%)
Query: 210 DARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTD 269
D CPDGS E K CP +C C P CD + + A
Sbjct: 106 DGEEECPDGSDESEATCTKQ-VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 270 LLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHC-CPAGFTC 328
L G+ C V DG C S GC C C G C
Sbjct: 165 TLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC---ADPACGPREFRCGGDGGGAC 221
Query: 329 DTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVS--SCPSSDTCCQLTSGEW 386
++ C++ ++A P P A C S +C S + C L W
Sbjct: 222 IPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGE-CVHL---GW 277
Query: 387 GCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQ 446
C + SD CP G E QC G+ ++A + H C+Q
Sbjct: 278 RCDGDRDCKDKSDEAD-CPLGTCRGDEFQCGDGTCVLA-----------IKH-----CNQ 320
Query: 447 HTSCPVG----------QTCCPSLGG-SWACCQLPHAVCCEDRQHCCPAGY 486
CP G C + GG S C L C CPAG+
Sbjct: 321 EQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC-----TCPAGF 366
Score = 37.7 bits (86), Expect = 0.030
Identities = 82/346 (23%), Positives = 109/346 (31%), Gaps = 80/346 (23%)
Query: 22 DGQFCPVACCLDPGGASYSCCRP--LLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSG 79
D CP C D + ++C + ++W C + C G S +
Sbjct: 77 DEDDCPKKTCAD---SDFTCDNGHCIHERWK----------CDGEEECPDG-SDESEATC 122
Query: 80 TSSCCPFPEAVACGD-GHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFS- 137
T CP E ++CG H C P + C DG + + + A C +F+C + S
Sbjct: 123 TKQVCP-AEKLSCGPTSHKCVPASWRC--DGEKDCEGGADEAGCATLCAPHEFQCGNRSC 179
Query: 138 -TCCVMVDGSWGC--------CPMPQASCCEDRV------HCCPHGAFCDL--------- 173
+ DG C C P E R C P CD
Sbjct: 180 LAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSD 239
Query: 174 -VHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCC 232
C P P A PA + S C RC DG C+ S + C
Sbjct: 240 EAAELCGRP---GPGATSAPAACATASQFACRSGECVHLGWRC-DGDRDCKDKSDEADC- 294
Query: 233 PMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPD 292
P TC D C D C L C +++ E C
Sbjct: 295 --PLGTCRGDEFQC--GDGTCVLAIKHCNQEQDCPDG---------------SDEAGCLQ 335
Query: 293 GYTCCRLQSGAWGCCPFTQAVCCEDHI--HC-CPAGFTCDTQKGTC 335
G C +G GC +C + I C CPAGF QK TC
Sbjct: 336 GLNECLHNNG--GC----SHICTDLKIGFECTCPAGFQLLDQK-TC 374
Score = 31.6 bits (70), Expect = 2.2
Identities = 30/123 (24%), Positives = 43/123 (34%), Gaps = 18/123 (14%)
Query: 458 PSLGGSWAC--CQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVG 515
P LGG C+ C +R C P+ + C+ + P A S
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADS---- 89
Query: 516 VKDVECGEGHFCHDNQTC-----CRDNR-QGWACCPYRQGVCCADRRHCCPAGFRCAARG 569
D C GH H+ C C D + A C + VC A++ C P +C
Sbjct: 90 --DFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQ--VCPAEKLSCGPTSHKCVPAS 145
Query: 570 TKC 572
+C
Sbjct: 146 WRC 148
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 54.3 bits (129), Expect = 3e-07
Identities = 127/636 (19%), Positives = 192/636 (30%), Gaps = 144/636 (22%)
Query: 26 CPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCP 85
C C + PGG ++C P D + T +SG++ C P
Sbjct: 3476 CSHLCLIKPGGKGFTCECP--DDFRT-----------------------LQLSGSTYCMP 3510
Query: 86 FPEAV--ACGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQ-CPDSQFECPDFSTCCVM 142
+ C + C P + C + C S ++ + C QF+C D
Sbjct: 3511 MCSSTQFLCANNEKCIPIWWKCDGQ-KDCSDGSDELALCPQRFCRLGQFQCSD------- 3562
Query: 143 VDGSWGCCPMPQASC-----C-----EDRVHCCPHGAFCD-----LVHTRCITPTGTHPL 187
G C PQ C C EDR+ C H CD + RCI P
Sbjct: 3563 -----GNCTSPQTLCNAHQNCPDGSDEDRLLCENH--HCDSNEWQCANKRCI-PESWQCD 3614
Query: 188 AKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTC-----CELPSGKYGCCPMPNATC--- 239
++ + +S C + RC +G C++ + P C
Sbjct: 3615 TFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSS 3674
Query: 240 -----------CSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEV 288
C + C P+ VC+ + ++N+ + H VGD +C
Sbjct: 3675 AHLCDNFTEFSCKTNYRCIPKWAVCNGVDD---CRDNSDEQGCEERTCHPVGDFRCKNHH 3731
Query: 289 SCP-----DGYTCCRLQSGAWGCCPFTQAVCCEDHI-----HCCPAGFTCDTQKGTCEQG 338
P DG C S C P C E C P+ + CD +
Sbjct: 3732 CIPLRWQCDGQNDCGDNSDEENCAP---RECTESEFRCVNQQCIPSRWICDHYNDCGDNS 3788
Query: 339 PHQVPWMEKA-PAHLSLPDPQALKRDVPCDNVSSC--PSSDTCCQLTSGEWGCCPIPEAV 395
+ M P + + ++ CD + C S + C + C
Sbjct: 3789 DERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFE 3848
Query: 396 CCSDHQHCCPQGYTCVAEGQCQRGSEIVAGL-----------EKMPARRASLSHPRDIGC 444
C + C P + C + C GS+ L + R SH G
Sbjct: 3849 C--KNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGV 3906
Query: 445 D----------QHTSCPVGQTCC--PSLGGSWACCQLPHAVCCEDRQHC--------CPA 484
D +H P + C G+ C +PH C+D C C
Sbjct: 3907 DDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHC--IPHDNVCDDADDCGDWSDELGCNK 3964
Query: 485 GYTCNVKARSCEKEVVSAQPATFLARSP---HVGVKD-VECGEGHFCHDNQTC---CRDN 537
G CE+ F+ V D C + + C TC CR+
Sbjct: 3965 GKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNT 4024
Query: 538 RQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCL 573
+ + C +DR G RCAA G+ L
Sbjct: 4025 KGSYECVCADGFTSMSDR-----PGKRCAAEGSSPL 4055
Score = 51.6 bits (122), Expect = 2e-06
Identities = 85/403 (21%), Positives = 126/403 (31%), Gaps = 90/403 (22%)
Query: 92 CGDGHHCCPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTCCVMVDGSWGCCP 151
CG GH C P + C + C + + C F+C C + SW C
Sbjct: 35 CGSGH-CIPADWRCDGT-KDCSDDADEIGCAVVTCQQGYFKCQSEGQC---IPNSWVCDQ 89
Query: 152 MPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDA 211
D C C C + + S C
Sbjct: 90 DQDCDDGSDERQDCSQST-CSSHQITC------------------SNGQCIPSEYRCDHV 130
Query: 212 RSRCPDGS--TCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTD 269
R CPDG+ C+ P+ + C D+ C CD K ++++
Sbjct: 131 RD-CPDGADENDCQYPTCEQLTC---------DNGACYNTSQKCDW---KVDCRDSSDEI 177
Query: 270 LLTKLPAHTVGDVKCDMEVSCPDGYTC-----CRLQSGAWGCCPFTQAVCCEDHIHCCPA 324
T++ H + C P Y C C+ S C T C + CP+
Sbjct: 178 NCTEICLHN--EFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPT----CGGYQFTCPS 231
Query: 325 G------FTCDTQ--------KGTCEQGPHQVPWMEKAPAHLSLPDP-QALKRDVPCDNV 369
G + CD + + CE GPH V + +P S P+ + + CD +
Sbjct: 232 GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVH--KCSPREWSCPESGRCISIYKVCDGI 289
Query: 370 SSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQH--------CCPQGY--------TCVAE 413
CP + ++G++ + A+ C H CP GY TCV
Sbjct: 290 LDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEF 349
Query: 414 GQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTC 456
CQ E P R L H C++ GQ C
Sbjct: 350 DDCQIWGICDQKCESRPGRH--LCH-----CEEGYILERGQYC 385
Score = 44.7 bits (104), Expect = 2e-04
Identities = 74/323 (22%), Positives = 100/323 (30%), Gaps = 80/323 (24%)
Query: 228 KYGCCPMPNATCCS--DHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCD 285
K G C +PN C D H + +C + + C S T +PAH +CD
Sbjct: 1034 KNGRC-VPNYYLCDGVDDCHDNSDEQLCGTLNNTC-SSSAFTCGHGECIPAHW----RCD 1087
Query: 286 MEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQK----GTCEQGPHQ 341
C DG + A C TQ C D+ C + CDT G+ E+ +
Sbjct: 1088 KRNDCVDGSDEHNCPTHAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSDEKNCNS 1145
Query: 342 VPWMEKAPAHLSLPDPQALKRDVPCDNVSSC--------------------PSSDTC--- 378
+ P+ + P+ + + CD C S D C
Sbjct: 1146 TETCQ--PSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGV 1203
Query: 379 ---------CQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEKM 429
C S E GC P +C SD C G +C + + G ++
Sbjct: 1204 TNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEH 1263
Query: 430 PA-------------------RRASLSHPRDIGC---DQHTSCPVGQTCCPSLGGSWACC 467
A RA L RD C CP CPS W C
Sbjct: 1264 NACVPKTCPSSYFHCDNGNCIHRAWLC-DRDNDCGDMSDEKDCPTQPFRCPS--WQWQC- 1319
Query: 468 QLPHAVCCEDRQHC-----CPAG 485
L H +C C CP G
Sbjct: 1320 -LGHNICVNLSVVCDGIFDCPNG 1341
Score = 42.0 bits (97), Expect = 0.002
Identities = 105/561 (18%), Positives = 166/561 (29%), Gaps = 125/561 (22%)
Query: 35 GGASYSCC--RPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSGTSSCCPFPEAVAC 92
G +S++C R + ++W C D C G + +V +C P A C
Sbjct: 2701 GASSFTCSNGRCISEEWK----------CDNDNDCGDGSDEMESVCALHTCSP--TAFTC 2748
Query: 93 GDGHHCCPRGFHCS--------ADGRSCFQRSGNNSVGAI----QCPDSQFECPDFSTCC 140
+G C + C +D C R N + + +C +F C C
Sbjct: 2749 ANGR-CVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCH 2807
Query: 141 VMVDGSWGCCPMPQASC------CEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQ 194
CP +C C + C P CD G +
Sbjct: 2808 DNNTSDEKNCP--DRTCQSGYTKCHNSNICIPRVYLCD----------GDNDCGDNSDEN 2855
Query: 195 RTNRAVALSSSVMCPDARSRCP------DGSTCCELPSGKYGCCPMPNATCCSDHL---- 244
T SS A RC D T C S + C TC +D
Sbjct: 2856 PTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDG 2915
Query: 245 -HCCPQDTVCDLIQS-----------KCLSKENATTDLLTK---------LPAHTVGDVK 283
C P + +CD +C ++ + ++ L +P V
Sbjct: 2916 GRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWV---- 2971
Query: 284 CDMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVP 343
CD +V C DGY Q+ C + C + C P F CD + +
Sbjct: 2972 CDGDVDCTDGYD--ENQNCTRRTCSENEFTC--GYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Query: 344 WMEKAPAH-LSLPDPQALKRDVPCDNVSSC-PSSDTCCQLTSGEWGCCPIPEAVCCSDHQ 401
+ + + + + + + CD + C SD L C PE C H+
Sbjct: 3028 LYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHL-------CHTPEPT-CPPHE 3079
Query: 402 HCCPQGYTCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLG 461
C G C + + ++ P GCD + C +L
Sbjct: 3080 FKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHN--------CTDTLT 3131
Query: 462 GSWACCQLPHAV-----CCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGV 516
+ C+ + + C D C + C+ K CE +G
Sbjct: 3132 SFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK---CENV---------------IGS 3173
Query: 517 KDVECGEGHFCHDNQTCCRDN 537
+C G+ + CR N
Sbjct: 3174 YICKCAPGYLREPDGKTCRQN 3194
Score = 38.1 bits (87), Expect = 0.023
Identities = 60/292 (20%), Positives = 91/292 (31%), Gaps = 78/292 (26%)
Query: 67 CSAGHSCIFTVS---GTSSC--------CP-------FPEAVACGDGHHCCPRGFHCSAD 108
C++G CI + G C CP + C + C P + C
Sbjct: 1194 CASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGH 1253
Query: 109 GRSCFQRSGNNSVGAIQCPDSQFECPDFSTC---CVMVDGSWGCCPMPQASCCEDRVHCC 165
+ +N+ CP S F C D C + D C M C + C
Sbjct: 1254 PDCLYGSDEHNACVPKTCPSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRC 1312
Query: 166 PHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELP 225
P + L H C+ + SV+C D CP+G+
Sbjct: 1313 PSWQWQCLGHNICV-----------------------NLSVVC-DGIFDCPNGT------ 1342
Query: 226 SGKYGCCPMPNATCCSDHLHCCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDV-KC 284
P+ N CSD C + V + +KCL L + T D+ +C
Sbjct: 1343 ----DESPLCNGNSCSDFNGGCTHECVQEPFGAKCL----CPLGFLLANDSKTCEDIDEC 1394
Query: 285 DMEVSCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCE 336
D+ SC C G++ C C G+ ++ TC+
Sbjct: 1395 DILGSCSQH---CYNMRGSFRC--------------SCDTGYMLESDGRTCK 1429
Score = 37.4 bits (85), Expect = 0.039
Identities = 63/298 (21%), Positives = 84/298 (28%), Gaps = 50/298 (16%)
Query: 287 EVSCPDGYTCCRLQSGAWGCC-------PFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGP 339
+V+ G C + G C P Q VC CP G + TCE P
Sbjct: 964 DVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCG------CPYGMRLASNHLTCEGDP 1017
Query: 340 HQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTC-----CQLTSGEWGCCPIPEA 394
P P Q PC N P+ C C S E C +
Sbjct: 1018 TNEP-----------PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNT 1066
Query: 395 VCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGLEK--MPARRASLSHPRDIGCDQHTSCPV 452
CS C G A +C + ++ V G ++ P + CD H
Sbjct: 1067 --CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISK 1124
Query: 453 GQTCCPSLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSP 512
C C C + C P+ + C R + V + S
Sbjct: 1125 NWVCDTDND----CGDGSDEKNCNSTETCQPSQFNCP-NHRCIDLSFVCDGDKDCVDGSD 1179
Query: 513 HVG------VKDVECGEGHFCH------DNQTCCRDNRQGWACCPYRQGVCCADRRHC 558
VG +C G C D C DN C G+C +D C
Sbjct: 1180 EVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQC 1237
Score = 35.4 bits (80), Expect = 0.15
Identities = 61/289 (21%), Positives = 86/289 (29%), Gaps = 54/289 (18%)
Query: 291 PDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPA 350
P+G C G W + ++ C + FTC G C
Sbjct: 2670 PNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSN--GRC--------------- 2712
Query: 351 HLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTC 410
+ + CDN + C + C P A C++ + C Y C
Sbjct: 2713 ---------ISEEWKCDNDNDCGDGSDEMESVCALHTCSPT--AFTCANGR-CVQYSYRC 2760
Query: 411 VAEGQCQRGSEIVAGL--------EKMPARRASLSHPRDIGCDQHTSCPVGQTC----CP 458
C GS+ L E M R + PR+ C+ +C T CP
Sbjct: 2761 DYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCI--PREFICNGVDNCHDNNTSDEKNCP 2818
Query: 459 SLGGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARSC--EKEVVSAQPATFLARSPHVGV 516
CQ + C + C P Y C+ C + T S
Sbjct: 2819 D-----RTCQSGYTKC-HNSNICIPRVYLCDGD-NDCGDNSDENPTYCTTHTCSSSEFQC 2871
Query: 517 KDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRC 565
C H+ D +T C D A C + + C AD C G RC
Sbjct: 2872 ASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKC--DGGRC 2918
>gi|154759249 keratin associated protein 10-11 [Homo sapiens]
Length = 298
Score = 53.9 bits (128), Expect = 4e-07
Identities = 74/306 (24%), Positives = 99/306 (32%), Gaps = 60/306 (19%)
Query: 200 VALSSSVMCPDARSR------CPDGSTCCELPSGKYGCC-PMPN-------ATCCSDHLH 245
+A S+ +C A S CP+ +CCE P CC P P+ +C S
Sbjct: 1 MAASTMSVCSSAYSDSWQVDDCPE--SCCEPPCSAPSCCAPAPSLSLVCTPVSCVSSP-- 56
Query: 246 CCPQDTVCDLIQSKCLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTCCRLQSGAWG 305
CC QS C S + C + SC CC
Sbjct: 57 CCQAACEPSACQSGCTSSCTPS----------------CCQQSSCQPA--CCTSSPCQQA 98
Query: 306 CCP--FTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRD 363
CC + VCC+ + C P C C Q Q + + P K
Sbjct: 99 CCVPVCCKTVCCKP-VCCVPV--CCGAASSCCRQSSCQPACCASSSCQPACCVPVCCK-- 153
Query: 364 VPCDNVSSCPS-SDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEI 422
P VS+C S +CCQ +S + CC S Q CC C C+ +
Sbjct: 154 -PVCCVSTCSEDSSSCCQQSSCQPACC-----TSSSYQQACCVP--VCCKTVYCKPICCV 205
Query: 423 VAGLEKMPARRASLSHPRDIGCDQHTSCPVGQTCCPSLGGSWACCQLPHAVCCEDRQHCC 482
RAS S + C +C C PS S C + + CC CC
Sbjct: 206 PV------CSRASSSRCQQPSCQP--ACCTTSCCRPSSSVSLLCHPVCRSTCCVPVSSCC 257
Query: 483 PAGYTC 488
+C
Sbjct: 258 APTSSC 263
Score = 52.4 bits (124), Expect = 1e-06
Identities = 71/298 (23%), Positives = 89/298 (29%), Gaps = 78/298 (26%)
Query: 290 CPDGYTCCRLQSGAWGCC---PFTQAVC----CEDHIHC--------CPAGFTCDTQKGT 334
CP+ +CC A CC P VC C C C +G T
Sbjct: 22 CPE--SCCEPPCSAPSCCAPAPSLSLVCTPVSCVSSPCCQAACEPSACQSGCTSSCTPSC 79
Query: 335 CEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEA 394
C+Q Q A PC P CC+ + CC +P
Sbjct: 80 CQQSSCQ----------------PACCTSSPCQQACCVP---VCCKTVCCKPVCC-VP-- 117
Query: 395 VCCSDHQHCCPQGY---TCVAEGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCP 451
VCC CC Q C A CQ + + P S C Q +SC
Sbjct: 118 VCCGAASSCCRQSSCQPACCASSSCQPACCVPVCCK--PVCCVSTCSEDSSSCCQQSSCQ 175
Query: 452 VGQTCCPSLGGSWACCQLPHAVCCED---RQHCCPAGYTCNVKARSCEKEVVSAQPATFL 508
CC S ACC VCC+ + CC C+ +A S + S QPA
Sbjct: 176 --PACCTSSSYQQACCV---PVCCKTVYCKPICCVP--VCS-RASSSRCQQPSCQPACCT 227
Query: 509 ARSPHVGVKDVECGEGHFCHDNQTCCRDNRQ-GWACCPYRQGVCCADRRHCCPAGFRC 565
+CCR + C P + CC CC C
Sbjct: 228 T----------------------SCCRPSSSVSLLCHPVCRSTCCVPVSSCCAPTSSC 263
Score = 47.0 bits (110), Expect = 5e-05
Identities = 60/244 (24%), Positives = 74/244 (30%), Gaps = 68/244 (27%)
Query: 20 CPDGQFCPVACCLDPGGASYSCCRPLLDKWPTTLSRHLGGPCQVDAHCSAGHSCIFTVSG 79
C C ACC+ P CC+P+ C V C A SC S
Sbjct: 89 CCTSSPCQQACCV-PVCCKTVCCKPV---------------CCVPVCCGAASSCCRQSSC 132
Query: 80 TSSCCPFPEAVACGDGHHCCPRGF---HCSADGRSCFQRSGNNSVGAIQCPDSQFECPDF 136
+CC CC CS D SC Q+S S C S ++
Sbjct: 133 QPACCASSSCQPACCVPVCCKPVCCVSTCSEDSSSCCQQS---SCQPACCTSSSYQ---- 185
Query: 137 STCCVMVDGSWGCCPMPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRT 196
CCV V CC+ V+C P C P +
Sbjct: 186 QACCVPV-------------CCKT-VYCKPI----------CCVPVCSR----------- 210
Query: 197 NRAVALSSSVMCPDARSRCPDGSTCCELPSGKYGCCPMPNATCCSDHLHCCPQDTVCDLI 256
A SS P + C S C S C P+ +TCC CC + C
Sbjct: 211 ----ASSSRCQQPSCQPACCTTSCCRPSSSVSLLCHPVCRSTCCVPVSSCCAPTSSC--- 263
Query: 257 QSKC 260
QS C
Sbjct: 264 QSSC 267
Score = 29.6 bits (65), Expect = 8.2
Identities = 42/155 (27%), Positives = 52/155 (33%), Gaps = 20/155 (12%)
Query: 16 AGTRCPDGQFCPVACCLDPGGASYSCCRPLLDK---WPTTLSRHLGGPCQVDAHCSAGHS 72
A + C C ACC +CC P+ K +T S CQ S +
Sbjct: 122 AASSCCRQSSCQPACCAS-SSCQPACCVPVCCKPVCCVSTCSEDSSSCCQ---QSSCQPA 177
Query: 73 CIFTVSGTSSCCPFPEAVACGDGHHCCPRGFH--CS-ADGRSCFQRSGNNSVGAIQC--P 127
C + S +CC C +C P CS A C Q S + C P
Sbjct: 178 CCTSSSYQQACC----VPVCCKTVYCKPICCVPVCSRASSSRCQQPSCQPACCTTSCCRP 233
Query: 128 DSQFE--CPDF--STCCVMVDGSWGCCPMPQASCC 158
S C STCCV V Q+SCC
Sbjct: 234 SSSVSLLCHPVCRSTCCVPVSSCCAPTSSCQSSCC 268
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 52.8 bits (125), Expect = 9e-07
Identities = 109/523 (20%), Positives = 166/523 (31%), Gaps = 119/523 (22%)
Query: 99 CPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC----CVMVDGSWGC--CP- 151
CP GF S +G +C EC C CV G++ C C
Sbjct: 943 CPAGFMASEEGTNCIDVD---------------ECLRPDVCGEGHCVNTVGAFRCEYCDS 987
Query: 152 ---MPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMC 208
M Q CED C D +C+ G++ R + C
Sbjct: 988 GYRMTQRGRCEDIDECLNPSTCPD---EQCVNSPGSYQCVPCTEGFR-------GWNGQC 1037
Query: 209 PDARSRCPDGSTC----CELPSGKYGCCPMPNATCCSDHLHC-----CPQDTVCDLIQSK 259
D C + + C C G Y C T DH HC C Q +C + +
Sbjct: 1038 LDV-DECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLC--VNGQ 1094
Query: 260 CLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC----CRLQSGAWGCCPFTQAVC- 314
C + E + + + +C+ C + C CR G++ C VC
Sbjct: 1095 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQC------VCD 1148
Query: 315 -----------CEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAH-LSLPDPQALKR 362
CED C C Q+G C + A ++ + PD L
Sbjct: 1149 QGYRASGLGDHCEDINECLEDKSVC--QRGDC---------INTAGSYDCTCPDGFQLDD 1197
Query: 363 DVPCDNVSSCPSSDTC-----CQLTSGEWGCCPIPEAVCCSDHQHC-----CPQGYTCVA 412
+ C +++ C C C T G + C +D + C C C +
Sbjct: 1198 NKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDS 1257
Query: 413 EGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPV-----GQTCCPSLGGSWACC 467
G C AG + + + GC C + G+ C ++ GS+ C
Sbjct: 1258 HGFCDN----TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC- 1312
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC 527
VC ++ Q P C + S + +V QP + + + D +
Sbjct: 1313 -----VCADENQEYSPMTGQCRSRT-STDLDVDVDQPKE-EKKECYYNLNDASLCDNVLA 1365
Query: 528 HD--NQTCCRDNRQGWA--C----CPYRQGVCCADRRHCCPAG 562
+ Q CC + GW C CP + A+ CP G
Sbjct: 1366 PNVTKQECCCTSGAGWGDNCEIFPCPV---LGTAEFTEMCPKG 1405
Score = 32.0 bits (71), Expect = 1.6
Identities = 39/178 (21%), Positives = 59/178 (33%), Gaps = 43/178 (24%)
Query: 83 CCPFPEAVACGDGHHC-CPRGFHCSADGRSC--FQRSGNNSV-----------GAIQC-- 126
C P E + HC C +GF SADGR+C NN+V G+ +C
Sbjct: 1213 CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLC 1272
Query: 127 ------PDSQFECPDFSTC-----------CVMVDGSWGCCPMPQASCCEDRVHCCPHGA 169
P C D + C C V+GS+ C C ++ P
Sbjct: 1273 YQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCV------CADENQEYSPMTG 1326
Query: 170 FCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
C + + P +K +L +V+ P+ + CC +G
Sbjct: 1327 QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ----ECCCTSGAG 1380
>gi|46249412 latent transforming growth factor beta binding protein 1
isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 52.8 bits (125), Expect = 9e-07
Identities = 109/523 (20%), Positives = 166/523 (31%), Gaps = 119/523 (22%)
Query: 99 CPRGFHCSADGRSCFQRSGNNSVGAIQCPDSQFECPDFSTC----CVMVDGSWGC--CP- 151
CP GF S +G +C EC C CV G++ C C
Sbjct: 617 CPAGFMASEEGTNCIDVD---------------ECLRPDVCGEGHCVNTVGAFRCEYCDS 661
Query: 152 ---MPQASCCEDRVHCCPHGAFCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMC 208
M Q CED C D +C+ G++ R + C
Sbjct: 662 GYRMTQRGRCEDIDECLNPSTCPD---EQCVNSPGSYQCVPCTEGFR-------GWNGQC 711
Query: 209 PDARSRCPDGSTC----CELPSGKYGCCPMPNATCCSDHLHC-----CPQDTVCDLIQSK 259
D C + + C C G Y C T DH HC C Q +C + +
Sbjct: 712 LDV-DECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLC--VNGQ 768
Query: 260 CLSKENATTDLLTKLPAHTVGDVKCDMEVSCPDGYTC----CRLQSGAWGCCPFTQAVC- 314
C + E + + + +C+ C + C CR G++ C VC
Sbjct: 769 CKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQC------VCD 822
Query: 315 -----------CEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAH-LSLPDPQALKR 362
CED C C Q+G C + A ++ + PD L
Sbjct: 823 QGYRASGLGDHCEDINECLEDKSVC--QRGDC---------INTAGSYDCTCPDGFQLDD 871
Query: 363 DVPCDNVSSCPSSDTC-----CQLTSGEWGCCPIPEAVCCSDHQHC-----CPQGYTCVA 412
+ C +++ C C C T G + C +D + C C C +
Sbjct: 872 NKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDS 931
Query: 413 EGQCQRGSEIVAGLEKMPARRASLSHPRDIGCDQHTSCPV-----GQTCCPSLGGSWACC 467
G C AG + + + GC C + G+ C ++ GS+ C
Sbjct: 932 HGFCDN----TAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLC- 986
Query: 468 QLPHAVCCEDRQHCCPAGYTCNVKARSCEKEVVSAQPATFLARSPHVGVKDVECGEGHFC 527
VC ++ Q P C + S + +V QP + + + D +
Sbjct: 987 -----VCADENQEYSPMTGQCRSRT-STDLDVDVDQPKE-EKKECYYNLNDASLCDNVLA 1039
Query: 528 HD--NQTCCRDNRQGWA--C----CPYRQGVCCADRRHCCPAG 562
+ Q CC + GW C CP + A+ CP G
Sbjct: 1040 PNVTKQECCCTSGAGWGDNCEIFPCPV---LGTAEFTEMCPKG 1079
Score = 32.0 bits (71), Expect = 1.6
Identities = 39/178 (21%), Positives = 59/178 (33%), Gaps = 43/178 (24%)
Query: 83 CCPFPEAVACGDGHHC-CPRGFHCSADGRSC--FQRSGNNSV-----------GAIQC-- 126
C P E + HC C +GF SADGR+C NN+V G+ +C
Sbjct: 887 CGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLC 946
Query: 127 ------PDSQFECPDFSTC-----------CVMVDGSWGCCPMPQASCCEDRVHCCPHGA 169
P C D + C C V+GS+ C C ++ P
Sbjct: 947 YQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCV------CADENQEYSPMTG 1000
Query: 170 FCDLVHTRCITPTGTHPLAKKLPAQRTNRAVALSSSVMCPDARSRCPDGSTCCELPSG 227
C + + P +K +L +V+ P+ + CC +G
Sbjct: 1001 QCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQ----ECCCTSGAG 1054
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.138 0.514
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,008,254
Number of Sequences: 37866
Number of extensions: 1757416
Number of successful extensions: 7780
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 277
Number of HSP's that attempted gapping in prelim test: 5470
Number of HSP's gapped (non-prelim): 1690
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.