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Search of human proteins with 4502929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] 728 0.0
gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 277 9e-75
gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 277 9e-75
gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 277 9e-75
gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 277 9e-75
gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 277 9e-75
gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 277 9e-75
gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 112 5e-25
gi|13540517 endothelial differentiation, sphingolipid G-protein-... 108 7e-24
gi|134244587 endothelial differentiation, sphingolipid G-protein... 104 1e-22
gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 103 2e-22
gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 103 2e-22
gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 103 2e-22
gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 102 4e-22
gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 102 7e-22
gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 101 1e-21
gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 101 1e-21
gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 100 2e-21
gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 96 5e-20
gi|4501951 adenosine A2b receptor [Homo sapiens] 91 2e-18
gi|5921992 adenosine A2a receptor [Homo sapiens] 90 4e-18
gi|5174535 melanocortin 5 receptor [Homo sapiens] 87 3e-17
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 82 7e-16
gi|119508433 melanocortin 4 receptor [Homo sapiens] 81 2e-15
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 80 4e-15
gi|170671732 melanocortin 3 receptor [Homo sapiens] 78 1e-14
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 76 4e-14
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 74 3e-13
gi|193083134 melanocortin 1 receptor [Homo sapiens] 74 3e-13
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 72 8e-13
>gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens]
Length = 360
Score = 728 bits (1878), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS 60
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
Sbjct: 1 MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS 60
Query: 61 SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS 120
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
Sbjct: 61 SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS 120
Query: 121 VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS 180
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
Sbjct: 121 VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS 180
Query: 181 ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD 240
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
Sbjct: 181 ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD 240
Query: 241 VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA 300
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
Sbjct: 241 VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA 300
Query: 301 LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC 360
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Sbjct: 301 LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC 360
>gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 108 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 167
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 168 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 227
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 228 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 287
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 288 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 347
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 348 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405
>gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 108 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 167
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 168 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 227
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 228 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 287
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 288 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 347
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 348 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405
>gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 108 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 167
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 168 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 227
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 228 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 287
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 288 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 347
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 348 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405
>gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 108 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 167
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 168 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 227
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 228 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 287
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 288 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 347
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 348 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405
>gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens]
Length = 472
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 108 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 167
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 168 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 227
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 228 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 287
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 288 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 347
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 348 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405
>gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens]
Length = 439
Score = 277 bits (709), Expect = 9e-75
Identities = 142/298 (47%), Positives = 196/298 (65%), Gaps = 15/298 (5%)
Query: 25 YMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS 84
+M+L+ Q+ A+AVL LG + LEN+ VL +IL S LR +PSY FIGSLA AD L S
Sbjct: 75 FMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGS 134
Query: 85 VVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKAL 144
V+F SF++FHVFH DS+ VFL K+G VT +FTASVGSL LTAIDRY+ + P +YK +
Sbjct: 135 VIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRI 194
Query: 145 LTRGRALVTLGIMWVLSALVSYLPLMGWTC--CPRPCSELFPLIPNDYLLSWLLFIAFLF 202
+TR +A+V +MW ++ +++ LPL+GW C CS++FP I YL+ W+ + L
Sbjct: 195 VTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLL 254
Query: 203 SGIIYTYGHVLWKAHQHVASL-------------SGHQDRQVPGMARMRLDVRLAKTLGL 249
I+Y Y ++LWKAH H + S QV + R+D+RLAKTL L
Sbjct: 255 LFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVL 314
Query: 250 VLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+L VL+ICW P+LA+M + + ++ +K FAFCSMLCL+NS VNP+IYALRS ++R
Sbjct: 315 ILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 372
>gi|4885295 G protein-coupled receptor 12 [Homo sapiens]
Length = 334
Score = 112 bits (280), Expect = 5e-25
Identities = 88/278 (31%), Positives = 139/278 (50%), Gaps = 22/278 (7%)
Query: 38 VLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97
VLCT G L + EN V+ +I + LR P +L IGSLA AD LA + +FV ++
Sbjct: 50 VLCTS-GTLISCENAIVVLIIFHNPSLRA-PMFLLIGSLALADLLAGIGLITNFVFAYL- 106
Query: 98 HGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIM 157
+ S+A L+ IG + +F+ASV SLL +DRYL L Y +Y + T V L ++
Sbjct: 107 --LQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVML 164
Query: 158 WVLSALVSYLPLMGWTCC--PRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHV--L 213
W S + LP+MGW C CS + PL N+ + + F+ F+F+ ++ Y + +
Sbjct: 165 WGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFL-FMFALMLQLYIQICKI 223
Query: 214 WKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTL 273
H H +L H + + TL ++L CW P +L + +
Sbjct: 224 VMRHAHQIALQHH----FLATSHYVTTRKGVSTLAIILGTFAACWMP------FTLYSLI 273
Query: 274 SDQV-KKAFAFCSML-CLINSMVNPVIYALRSGEIRSS 309
+D + + ++L NS++NPVIYA R+ EI+ +
Sbjct: 274 ADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKA 311
>gi|13540517 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 8 [Homo sapiens]
Length = 398
Score = 108 bits (270), Expect = 7e-24
Identities = 85/281 (30%), Positives = 131/281 (46%), Gaps = 12/281 (4%)
Query: 35 AVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNF 94
A AV+C + LEN+AVL L+L H P +L +GSL +D LA +A + +
Sbjct: 38 ADAVVCLAVCAFIVLENLAVL-LVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLS 96
Query: 95 HVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCL-RYPPSYKALLTRGRALVT 153
S A++ + G V + TASV SLL A++R L + R P+ + +RGR L
Sbjct: 97 GPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPA--PVSSRGRTLAM 154
Query: 154 LGIMWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGH 211
W +S L+ LP +GW C R CS + PL Y+L +L + + I Y
Sbjct: 155 AAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYAR 214
Query: 212 VLWKAHQHVASLSGHQDRQVPGMARMRLDVR---LAKTLGLVLAVLLICWFPVLALMAHS 268
+ + + L R R R L +TL +VL + CW P+ L+
Sbjct: 215 IYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLD 274
Query: 269 LA--TTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
+A + +A F L + NS++NP+IY L + ++R
Sbjct: 275 VACPARTCPVLLQADPFLG-LAMANSLLNPIIYTLTNRDLR 314
>gi|134244587 endothelial differentiation, sphingolipid
G-protein-coupled receptor, 5 [Homo sapiens]
Length = 353
Score = 104 bits (260), Expect = 1e-22
Identities = 84/317 (26%), Positives = 146/317 (46%), Gaps = 27/317 (8%)
Query: 6 VTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLR 65
V E N +K+ L++ + S + +LC + +EN+ VL + + +
Sbjct: 14 VQEHYNYTKETLETQETTSRQVASA----FIVILCCAI----VVENLLVLIAVARNSKFH 65
Query: 66 RKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLL 125
YLF+G+LA +D LA V F + + + + + GS +T +ASV SLL
Sbjct: 66 -SAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLL 124
Query: 126 LTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCP--RPCSELF 183
AI+R++ + Y + + R L+ +G W++S ++ LP++GW C CS +
Sbjct: 125 AIAIERHVAIAKVKLYGSDKSC-RMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVL 183
Query: 184 PLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRL 243
PL Y+L + + + I+ Y + + S H D P + L
Sbjct: 184 PLYAKHYVLCVVTIFSIILLAIVALYVRI------YCVVRSSHADMAAP------QTLAL 231
Query: 244 AKTLGLVLAVLLICWFPVLALMAHSLATTLSD--QVKKAFAFCSMLCLINSMVNPVIYAL 301
KT+ +VL V ++CW P +++ A + + KA F ++ L NS++NPVIY
Sbjct: 232 LKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTL-NSLLNPVIYTW 290
Query: 302 RSGEIRSSAHHCLAHWK 318
RS ++R L W+
Sbjct: 291 RSRDLRREVLRPLQCWR 307
>gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 103 bits (258), Expect = 2e-22
Identities = 74/269 (27%), Positives = 127/269 (47%), Gaps = 10/269 (3%)
Query: 49 LENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLL 108
L N+ V+ I + + P Y + +LA ADF A + + N + + +LL
Sbjct: 65 LANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLL 123
Query: 109 KIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLP 168
+ G + + TASV +LL AI+R++ + + ++ R +V + ++W ++ ++ +P
Sbjct: 124 RQGLIDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIP 182
Query: 169 LMGWTC-CP-RPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGH 226
+GW C C CS + PL + YL+ W +F F ++ Y H+ Q +S H
Sbjct: 183 SVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRH 242
Query: 227 QDRQVPGMARMR-LDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCS 285
G R R + L KT+ +VL +ICW P L L+ + D V F
Sbjct: 243 SS----GPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCD-VLAYEKFFL 297
Query: 286 MLCLINSMVNPVIYALRSGEIRSSAHHCL 314
+L NS +NP+IY+ R E+ ++ L
Sbjct: 298 LLAEFNSAMNPIIYSYRDKEMSATFRQIL 326
>gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens]
Length = 364
Score = 103 bits (258), Expect = 2e-22
Identities = 74/269 (27%), Positives = 127/269 (47%), Gaps = 10/269 (3%)
Query: 49 LENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLL 108
L N+ V+ I + + P Y + +LA ADF A + + N + + +LL
Sbjct: 65 LANLLVMVAIYVNRRFHF-PIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLL 123
Query: 109 KIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLP 168
+ G + + TASV +LL AI+R++ + + ++ R +V + ++W ++ ++ +P
Sbjct: 124 RQGLIDTSLTASVANLLAIAIERHITV-FRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIP 182
Query: 169 LMGWTC-CP-RPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGH 226
+GW C C CS + PL + YL+ W +F F ++ Y H+ Q +S H
Sbjct: 183 SVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRH 242
Query: 227 QDRQVPGMARMR-LDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCS 285
G R R + L KT+ +VL +ICW P L L+ + D V F
Sbjct: 243 SS----GPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCD-VLAYEKFFL 297
Query: 286 MLCLINSMVNPVIYALRSGEIRSSAHHCL 314
+L NS +NP+IY+ R E+ ++ L
Sbjct: 298 LLAEFNSAMNPIIYSYRDKEMSATFRQIL 326
>gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo
sapiens]
Length = 384
Score = 103 bits (258), Expect = 2e-22
Identities = 83/281 (29%), Positives = 133/281 (47%), Gaps = 23/281 (8%)
Query: 35 AVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGS-----LAGADFLASVVFAC 89
A+ L L LEN+ VL I S + RR Y + L GA +LA+V+ +
Sbjct: 48 ALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSG 107
Query: 90 SFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGR 149
+ F + + A + L+ G + AS SLL TA +R+ + P + R
Sbjct: 108 ART-FRL-----APAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSR 161
Query: 150 ALVTLGIMWVLSALVSYLPLMGWTC-CP-RPCSELFPLIPNDYLLSWLLFIAFLFSGIIY 207
+G+ W+L+AL+ LPL+GW C C CS L PL Y+L L+ A + + I+
Sbjct: 162 VYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMG 221
Query: 208 TYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAH 267
YG + + SG ++ P A R RL KT+ ++L L+CW P+ L+
Sbjct: 222 LYGAIF-----RLVQASG---QKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLA 273
Query: 268 SL--ATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEI 306
+ + + + + + L ++NS VNP+IY+ RS E+
Sbjct: 274 DVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREV 314
>gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens]
Length = 378
Score = 102 bits (255), Expect = 4e-22
Identities = 81/304 (26%), Positives = 140/304 (46%), Gaps = 17/304 (5%)
Query: 34 TAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVN 93
T VL ++ LEN+ VL I +++ + Y FIG+LA D LA + + + +
Sbjct: 40 TLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNR-MYFFIGNLALCDLLAGIAYKVNILM 98
Query: 94 FHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVT 153
S V+ L+ GS+ + AS SLL AI+R+L + Y A R R +
Sbjct: 99 SGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDAN-KRHRVFLL 157
Query: 154 LGIMWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGH 211
+G+ W+++ + LP++GW C CS + PL Y+ + + I+ Y
Sbjct: 158 IGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYAR 217
Query: 212 VLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLAT 271
+ + ++ H + + + L +T+ +V++V + CW P+ L +A
Sbjct: 218 IYFLVKSSSRKVANHNNSE--------RSMALLRTVVIVVSVFIACWSPLFILFLIDVAC 269
Query: 272 TLS--DQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAK 329
+ + KA F +L ++NS +NPVIY L S E+R + + + VRG G+ A
Sbjct: 270 RVQACPILFKAQWFI-VLAVLNSAMNPVIYTLASKEMRRAFFRLVCNC--LVRGRGARAS 326
Query: 330 EEAP 333
P
Sbjct: 327 PIQP 330
>gi|4885325 G protein-coupled receptor 3 [Homo sapiens]
Length = 330
Score = 102 bits (253), Expect = 7e-22
Identities = 79/282 (28%), Positives = 135/282 (47%), Gaps = 19/282 (6%)
Query: 31 PQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACS 90
P A V+ + G L + EN V+ +I+ + R P +L +GSLA AD LA +
Sbjct: 38 PSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRA-PMFLLVGSLAVADLLAGLGLV-- 94
Query: 91 FVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRA 150
++F + S + L+ +G + M FTAS+GSLL +DRYL L +Y + T R
Sbjct: 95 -LHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRT 153
Query: 151 LVTLGIMWVLSALVSYLPLMGWTCCP--RPCSELFPLIPNDYLLSWLLFIAFLFSGIIYT 208
V L ++W + + LP++ W C C ++PL N ++ + F +F ++
Sbjct: 154 YVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFF-MVFGIMLQL 212
Query: 209 YGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFP--VLALMA 266
Y + +H ++ Q +P + +A TL +VL CW P V L+
Sbjct: 213 YAQICRIVCRHAQQIA-LQRHLLPASHYVATRKGIA-TLAVVLGAFAACWLPFTVYCLLG 270
Query: 267 HSLATTLSDQVKKAFAFCSML-CLINSMVNPVIYALRSGEIR 307
+ + L + + ++L NSM+NP+IYA R+ +++
Sbjct: 271 DAHSPPL-------YTYLTLLPATYNSMINPIIYAFRNQDVQ 305
>gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens]
Length = 382
Score = 101 bits (251), Expect = 1e-21
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 16/279 (5%)
Query: 37 AVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHV 96
+V+ L+ LEN+ VL I + + R P Y FIG+LA +D LA V + + +
Sbjct: 49 SVVFILICCFIILENIFVLLTIWKTKKFHR-PMYYFIGNLALSDLLAGVAYTANLLLSGA 107
Query: 97 FHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRG----RALV 152
+ A + L+ GS+ + +ASV SLL AI+RY+ + K L G R +
Sbjct: 108 TTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITM-----LKMKLHNGSNNFRLFL 162
Query: 153 TLGIMWVLSALVSYLPLMGWTCCP--RPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYG 210
+ WV+S ++ LP+MGW C CS + PL Y+L L I+ Y
Sbjct: 163 LISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYC 222
Query: 211 HVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFP--VLALMAHS 268
+ L+ ++ + + + L KT+ +VL+V + CW P +L L+
Sbjct: 223 RIYSLVRTRSRRLTFRKNISKASRSSEK-SLALLKTVIIVLSVFIACWAPLFILLLLDVG 281
Query: 269 LATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIR 307
D + +A F +L ++NS NP+IY L + E+R
Sbjct: 282 CKVKTCDILFRAEYFL-VLAVLNSGTNPIIYTLTNKEMR 319
>gi|4885341 G protein-coupled receptor 6 [Homo sapiens]
Length = 362
Score = 101 bits (251), Expect = 1e-21
Identities = 90/276 (32%), Positives = 130/276 (47%), Gaps = 21/276 (7%)
Query: 38 VLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVF 97
VL + G + A EN V+ LI S+ LR P ++ +GSLA AD LA C + VF
Sbjct: 77 VLLCVSGTVIAGENALVVALIASTPALRT-PMFVLVGSLATADLLAG----CGLILHFVF 131
Query: 98 -HGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGI 156
+ V S+ V LL +G + +F ASV SLL +DRYL L +Y + T + L
Sbjct: 132 QYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA 191
Query: 157 MWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDY-LLSWLLFIAF-LFSGIIYTYGHV 212
W +S + LP++GW C CS + PL + LLS F+ F + + V
Sbjct: 192 TWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQV 251
Query: 213 LWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATT 272
+W+ H H +L H P +A R V TL +VL W P
Sbjct: 252 VWR-HAHQIALQQH-CLAPPHLAATRKGV---GTLAVVLGTFGASWLPFAI-----YCVV 301
Query: 273 LSDQVKKAFAFCSML-CLINSMVNPVIYALRSGEIR 307
S + + + ++L NSM+NP+IYA R+ EI+
Sbjct: 302 GSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQ 337
>gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens]
Length = 353
Score = 100 bits (249), Expect = 2e-21
Identities = 76/281 (27%), Positives = 138/281 (49%), Gaps = 21/281 (7%)
Query: 36 VAVLC--TLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVN 93
V VLC T L N V+ ++ + + P Y + +LA ADF A + + F+
Sbjct: 31 VIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHF-PFYYLLANLAAADFFAGIAYV--FLM 87
Query: 94 FHVFHGVDSKAV----FLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGR 149
F+ G SK + + L+ G + + TAS+ +LL+ A++R++ + + L T+ R
Sbjct: 88 FNT--GPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNL-TKKR 144
Query: 150 ALVTLGIMWVLSALVSYLPLMGWTCCPR--PCSELFPLIPNDYLLSWLL--FIAFLFSGI 205
+ + ++W ++ + +P +GW C CS L P+ YL+ W + +AFL +
Sbjct: 145 VTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVV 204
Query: 206 IYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALM 265
+Y +V K +V LS H + +R R ++L KT+ VL ++CW P L ++
Sbjct: 205 VYLRIYVYVKRKTNV--LSPHTSGSI---SRRRTPMKLMKTVMTVLGAFVVCWTPGLVVL 259
Query: 266 AHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEI 306
V+ + +L L+NS+VNP+IY+ + ++
Sbjct: 260 LLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDM 300
>gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens]
Length = 351
Score = 95.9 bits (237), Expect = 5e-20
Identities = 82/321 (25%), Positives = 141/321 (43%), Gaps = 18/321 (5%)
Query: 31 PQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACS 90
P+ V L + +L L N+ V+ I S+ + + P Y +G+LA AD A V +
Sbjct: 30 PKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQ-PIYYLLGNLAAADLFAGVAYL-- 86
Query: 91 FVNFHVFHGVDSKAV--FLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRG 148
F+ FH ++ + L+ G + + TASV +LL A++R+ + + L RG
Sbjct: 87 FLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRL-PRG 145
Query: 149 RALVTLGIMWVLSALVSYLPLMGWTC-CPRP-CSELFPLIPNDYLLSWLLFIAFLFSGII 206
R ++ + +WV + + LP W C C CS + PL+ YL W L +F ++
Sbjct: 146 RVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMV 205
Query: 207 YTYGHVLWKAHQHVASLSGHQDRQVPGMARMR-LDVRLAKTLGLVLAVLLICWFPVLALM 265
Y + + + V ++ H V R R + L KT+ ++L ++CW P ++
Sbjct: 206 AVYTRIFFYVRRRVQRMAEH----VSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVL 261
Query: 266 AHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLG 325
S V + +L NS+VN +Y+ R E+R + L C L
Sbjct: 262 LLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLL-----CCACLR 316
Query: 326 SEAKEEAPRSSVTETEADGKI 346
+E +S + A +I
Sbjct: 317 QSTRESVHYTSSAQGGASTRI 337
>gi|4501951 adenosine A2b receptor [Homo sapiens]
Length = 332
Score = 90.5 bits (223), Expect = 2e-18
Identities = 79/311 (25%), Positives = 143/311 (45%), Gaps = 27/311 (8%)
Query: 32 QKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSF 91
Q L ++ LS NV V + +++ L+ +Y F+ SLA AD +A +FA F
Sbjct: 6 QDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNY-FLVSLAAAD-VAVGLFAIPF 63
Query: 92 -VNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRA 150
+ + D L + +T +S+ SLL A+DRYL + P YK+L+T RA
Sbjct: 64 AITISLGFCTDFYGCLFLACFVLVLT-QSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRA 122
Query: 151 LVTLGIMWVLSALVSYLPLMGWTC-------CPRP--------CSELFPLIPNDYLLSWL 195
+ ++WVL+ + P +GW C P C + L N +S++
Sbjct: 123 RGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYM 182
Query: 196 LFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRL----DVRLAKTLGLVL 251
++ F F G + ++ + + ++ Q ++ M R ++ AK+L +++
Sbjct: 183 VY--FNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV 240
Query: 252 AVLLICWFPVLALMAHSLATTLSDQVKKAFA--FCSMLCLINSMVNPVIYALRSGEIRSS 309
+ +CW PV A+ +L + K +A +L NS+VNP++YA R+ + R +
Sbjct: 241 GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT 300
Query: 310 AHHCLAHWKKC 320
H ++ + C
Sbjct: 301 FHKIISRYLLC 311
>gi|5921992 adenosine A2a receptor [Homo sapiens]
Length = 412
Score = 89.7 bits (221), Expect = 4e-18
Identities = 80/292 (27%), Positives = 136/292 (46%), Gaps = 34/292 (11%)
Query: 43 LGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDS 102
+ +L+ L NV V + + + L+ +Y F+ SLA AD +A V A F + G +
Sbjct: 16 IAVLAILGNVLVCWAVWLNSNLQNVTNY-FVVSLAAAD-IAVGVLAIPFA-ITISTGFCA 72
Query: 103 KAVFLLKIGSVTMTFT-ASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLS 161
L I + T +S+ SLL AIDRY+ +R P Y L+T RA + I WVLS
Sbjct: 73 ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLS 132
Query: 162 ALVSYLPLMGWTCCPRP---------CSE-----LF-PLIPNDYLLSWLLFIAFLFSGII 206
+ P++GW C +P C E LF ++P +Y++ + F L ++
Sbjct: 133 FAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLL 192
Query: 207 Y--TYGHVLWKAHQHVASLSGHQDRQVPG---MARMRLDVRLAKTLGLVLAVLLICWFPV 261
Y + A + + + + + +PG + ++ +V AK+L +++ + +CW P+
Sbjct: 193 MLGVYLRIFLAARRQLKQM---ESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPL 249
Query: 262 LALMAHSLATTLSDQVKKAFAFCSMLCLI----NSMVNPVIYALRSGEIRSS 309
+ + T A + L ++ NS+VNP IYA R E R +
Sbjct: 250 HII---NCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQT 298
>gi|5174535 melanocortin 5 receptor [Homo sapiens]
Length = 325
Score = 86.7 bits (213), Expect = 3e-17
Identities = 90/305 (29%), Positives = 144/305 (47%), Gaps = 45/305 (14%)
Query: 35 AVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNF 94
AV V TL G++S LEN+ V+ I+ + L P Y F+ SLA AD L S+ A +
Sbjct: 39 AVEVFLTL-GVISLLENILVIGAIVKNKNLH-SPMYFFVCSLAVADMLVSMSSAWETITI 96
Query: 95 HVF---HGVDSKAVFLLKIGSV-----TMTFTASVGSLLLTAIDRYLCLRYPPSYKALLT 146
++ H V + A F+ I +V ++ AS+ SLL A+DRY+ + Y Y ++T
Sbjct: 97 YLLNNKHLVIADA-FVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMT 155
Query: 147 RGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLI-PNDYLLSWL--LFIAFLFS 203
R+ A+++ + W C C +F L + Y++ L +F A LF
Sbjct: 156 ARRS----------GAIIAGI----WAFC-TGCGIVFILYSESTYVILCLISMFFAMLFL 200
Query: 204 GIIYTYGHVLWKAHQHVASLSGHQDRQVPG--MARMRLDVRLAKTLGLVLAVLLICWFPV 261
++ Y H+ A HV ++ +PG AR R ++ A T+ ++L V +CW P
Sbjct: 201 -LVSLYIHMFLLARTHVKRIAA-----LPGASSARQRTSMQGAVTVTMLLGVFTVCWAPF 254
Query: 262 ---LALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWK 318
L LM + F +L + NS+++P+IYA RS E+R + +
Sbjct: 255 FLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEII---- 310
Query: 319 KCVRG 323
C RG
Sbjct: 311 -CCRG 314
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 82.0 bits (201), Expect = 7e-16
Identities = 82/326 (25%), Positives = 152/326 (46%), Gaps = 44/326 (13%)
Query: 36 VAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADF---LASVVFACSFV 92
+ ++ +L+ L NV V+ I +L+ +Y FI SLA AD LA V F + +
Sbjct: 36 MGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNY-FITSLACADLVMGLAVVPFGAAHI 94
Query: 93 NFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALV 152
++ + F I + TAS+ +L + A+DRY + P Y++LLT+ +A V
Sbjct: 95 LMKMWTFGNFWCEFWTSID--VLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARV 152
Query: 153 TLGIMWVLSALVSYLPL-MGW---------------TCCPRPCSELFPLIPNDYLLSW-- 194
+ ++W++S L S+LP+ M W TCC ++ + + + ++S+
Sbjct: 153 IILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASS--IVSFYV 210
Query: 195 -LLFIAFLFSGIIYTYGHVLWKAHQ-----HVASLSG-HQD-RQVPGMARMR----LDVR 242
L+ + F++S + L K + HV +LS QD R G+ R + +
Sbjct: 211 PLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHK 270
Query: 243 LAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQV--KKAFAFCSMLCLINSMVNPVIYA 300
KTLG+++ +CW P + ++ + D + K+ + + + +NS NP+IY
Sbjct: 271 ALKTLGIIMGTFTLCWLPFFIV---NIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC 327
Query: 301 LRSGEIRSSAHHCLAHWKKCVRGLGS 326
RS + R + L + ++ G+
Sbjct: 328 -RSPDFRIAFQELLCLRRSSLKAYGN 352
>gi|119508433 melanocortin 4 receptor [Homo sapiens]
Length = 332
Score = 80.9 bits (198), Expect = 2e-15
Identities = 75/280 (26%), Positives = 125/280 (44%), Gaps = 34/280 (12%)
Query: 43 LGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDS 102
LG++S LEN+ V+ I + L P Y FI SLA AD L SV + + + D+
Sbjct: 54 LGVISLLENILVIVAIAKNKNLH-SPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDT 112
Query: 103 KAV-FLLKIGSVT-----MTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGI 156
A F + I +V + AS+ SLL A+DRY + Y Y ++T R + +
Sbjct: 113 DAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISC 172
Query: 157 MWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKA 216
+W + L ++ S+ +I L + F +Y + ++ +
Sbjct: 173 IWAACTVSGILFII--------YSDSSAVI---ICLITMFFTMLALMASLYVHMFLMARL 221
Query: 217 H-QHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSD 275
H + +A L G G R +++ A TL +++ V ++CW P H +
Sbjct: 222 HIKRIAVLPG------TGAIRQGANMKGAITLTILIGVFVVCWAP---FFLHLIFYISCP 272
Query: 276 QVKKAFAFCS------MLCLINSMVNPVIYALRSGEIRSS 309
Q F S +L + NS+++P+IYALRS E+R +
Sbjct: 273 QNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKT 312
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 79.7 bits (195), Expect = 4e-15
Identities = 81/302 (26%), Positives = 132/302 (43%), Gaps = 41/302 (13%)
Query: 45 LLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKA 104
L + + N+ V+ + + LR +Y FI +LA AD L S V
Sbjct: 57 LFAIVGNILVILSVACNRHLRTPTNY-FIVNLAMADLLLSFTVLPFSAALEVLGYWVLGR 115
Query: 105 VFLLKIGSV-TMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSAL 163
+F +V + TAS+ SL +IDRY+ +RY Y L+TR +A++ L +WVLS +
Sbjct: 116 IFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTV 175
Query: 164 VSYLPLMGWT-----------CCPRPCSELFPLIPNDYLLSWLLFIAF------------ 200
+S PL+GW P LF + + Y+ ++ + +
Sbjct: 176 ISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTK 235
Query: 201 -LFSGIIYTYGH---VLWKAHQ---HVASLS-----GHQDRQ--VPGMARMRLDVRLAKT 246
L +G++ + + + H H +LS GH R + + + + AKT
Sbjct: 236 NLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKT 295
Query: 247 LGLVLAVLLICWFP-VLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGE 305
LG+V+ + ++CW P +AL SL +TL F L NS +NP+IY S E
Sbjct: 296 LGIVVGMFILCWLPFFIALPLGSLFSTLKPP-DAVFKVVFWLGYFNSCLNPIIYPCSSKE 354
Query: 306 IR 307
+
Sbjct: 355 FK 356
>gi|170671732 melanocortin 3 receptor [Homo sapiens]
Length = 323
Score = 78.2 bits (191), Expect = 1e-14
Identities = 71/286 (24%), Positives = 126/286 (44%), Gaps = 33/286 (11%)
Query: 43 LGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHG--V 100
LG++S LEN+ V+ ++ + L P Y F+ SLA AD L SV A + + H +
Sbjct: 48 LGIVSLLENILVILAVVRNGNLH-SPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYL 106
Query: 101 DSKAVFLLKIGSV-----TMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLG 155
+ F+ + ++ ++ AS+ +LL A+DRY+ + Y Y +++T +AL +
Sbjct: 107 TFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIV 166
Query: 156 IMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYL----LSWLLFIAFLFSGIIYTYGH 211
+WV CC C +F + + L + F L G +Y +
Sbjct: 167 AIWV--------------CC-GVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMF 211
Query: 212 VLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPV---LALMAHS 268
+ + H + D P + ++ A T+ ++L V + CW P L L+
Sbjct: 212 LFARLHVKRIAALPPADGVAP---QQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITC 268
Query: 269 LATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCL 314
F +L + NS+++P+IYA RS E+R++ L
Sbjct: 269 PTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREIL 314
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 76.3 bits (186), Expect = 4e-14
Identities = 86/300 (28%), Positives = 136/300 (45%), Gaps = 43/300 (14%)
Query: 37 AVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLAS-VVFACSFVNFH 95
A LC ++ L +A ++ L ++ + R S F+ SL +D + VV + +N
Sbjct: 31 AALCVVIALTAAANSL--LIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNAL 88
Query: 96 VFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLG 155
V ++ + LL M +AS+ +L L ++DRYL + P YK +T RAL +
Sbjct: 89 YGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVL 148
Query: 156 IMWVLSALVSYLP-LMGW-------TCCPRPCSELFPLIPNDYLLSWLLFIAFLFSG-II 206
W L+AL S+LP L+GW P C L +P + S L F FL SG I
Sbjct: 149 GAWSLAALASFLPLLLGWHELGHARPPVPGQC-RLLASLPFVLVASGLTF--FLPSGAIC 205
Query: 207 YTYGHVLWKAHQ---HVASLS------GHQDRQVPGMAR---------------MRLDVR 242
+TY +L A + VASL+ + QVP R R ++
Sbjct: 206 FTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALK 265
Query: 243 LAKTLGLVLAVLLICWFP-VLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYAL 301
+ TLG++L + + W P +A + ++ +S + F + L NS +NP+IY L
Sbjct: 266 ASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGL---FDVLTWLGYCNSTMNPIIYPL 322
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 73.6 bits (179), Expect = 3e-13
Identities = 89/357 (24%), Positives = 146/357 (40%), Gaps = 72/357 (20%)
Query: 28 LSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVF 87
LS + +L L+ LL NV V+ I + +L+ + LFI SLA AD + ++
Sbjct: 53 LSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTN-LFIMSLASADLVMGLLV 111
Query: 88 ACSFVNFHVFHGVDSKAVFLLKIGSV-TMTFTASVGSLLLTAIDRYLCLRYPPSYKALLT 146
V+ + + F SV + TAS+ +L + A+DRYL + P Y++LLT
Sbjct: 112 VPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLT 171
Query: 147 RGRALVTLGIMWVLSALVSYLP-LMGW---------------TCCPRPCSELFPLIPNDY 190
R RA + +W +SALVS+LP LM W CC + + + +
Sbjct: 172 RARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASS-- 229
Query: 191 LLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMAR-------------- 236
++S+ + + + + Y V +A + V + + R + G AR
Sbjct: 230 VVSFYVPLCIM----AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAP 285
Query: 237 --------------------------MRL----DVRLAKTLGLVLAVLLICWFP-VLALM 265
RL + + KTLG+++ V +CW P LA +
Sbjct: 286 PPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANV 345
Query: 266 AHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVR 322
+ L + F F + L NS NP+IY RS + R + L ++ R
Sbjct: 346 VKAFHRELVPD--RLFVFFNWLGYANSAFNPIIYC-RSPDFRKAFQGLLCCARRAAR 399
>gi|193083134 melanocortin 1 receptor [Homo sapiens]
Length = 317
Score = 73.6 bits (179), Expect = 3e-13
Identities = 73/285 (25%), Positives = 124/285 (43%), Gaps = 32/285 (11%)
Query: 43 LGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASV--VFACSFVNFHVFHGV 100
LGL+S +EN V+ I + L P Y FI LA +D L S V + + +
Sbjct: 48 LGLVSLVENALVVATIAKNRNLH-SPMYCFICCLALSDLLVSGSNVLETAVILLLEAGAL 106
Query: 101 DSKAVFLLKIGSVTMTFTAS--VGSLLLT---AIDRYLCLRYPPSYKALLTRGRALVTLG 155
++A L ++ +V T S + SL A+DRY+ + Y Y +++T RA +
Sbjct: 107 VARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVA 166
Query: 156 IMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGII---YTYGHV 212
+WV S + S L + + D++ L + F + ++ Y H+
Sbjct: 167 AIWVASVVFSTLFIAYY----------------DHVAVLLCLVVFFLAMLVLMAVLYVHM 210
Query: 213 LWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPV---LALMAHSL 269
L +A QH ++ RQ P ++ A TL ++L + +CW P L L+
Sbjct: 211 LARACQHAQGIARLHKRQRP--VHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCP 268
Query: 270 ATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCL 314
+ K F L + N++++P+IYA S E+R + L
Sbjct: 269 EHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVL 313
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 72.0 bits (175), Expect = 8e-13
Identities = 83/357 (23%), Positives = 141/357 (39%), Gaps = 59/357 (16%)
Query: 8 EIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRK 67
E +N S + +++ D L K ++AV+ +++ L + L N VL IL + +L
Sbjct: 14 EASNRSLNATETSEAWDPRTLQA-LKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTP 72
Query: 68 PSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFL-LKIGSVTMTFTASVGSLLL 126
+YL IGSLA D L S++ + + + H + + + + S TAS+ L +
Sbjct: 73 ANYL-IGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCV 131
Query: 127 TAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLI 186
A+DRY + Y T G A + I+W +S +S PL W + E+ +
Sbjct: 132 IALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLF-WRQA-KAQEEMSDCL 189
Query: 187 PNDYLLSWLLF-----------IAFLFSGIIY------------TYGHVLWKAHQHVASL 223
N +S+ ++ + + G IY YG AH S
Sbjct: 190 VNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSA 249
Query: 224 ------------SGHQDRQVPGMARMRLDVRLA------------------KTLGLVLAV 253
GH + + ++LA K LG++L
Sbjct: 250 GSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGA 309
Query: 254 LLICWFPVLALMAHSLATTLSDQVKKA-FAFCSMLCLINSMVNPVIYALRSGEIRSS 309
+ICW P + S + A F F + L +NS++NP+IY + + E R +
Sbjct: 310 FIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQA 366
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.138 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,971,809
Number of Sequences: 37866
Number of extensions: 513526
Number of successful extensions: 2886
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 415
Number of HSP's that attempted gapping in prelim test: 2153
Number of HSP's gapped (non-prelim): 815
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.