BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 [Homo sapiens] (763 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ... 1549 0.0 gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ... 1513 0.0 gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ... 1196 0.0 gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ... 757 0.0 gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 755 0.0 gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 744 0.0 gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 659 0.0 gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 636 0.0 gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 551 e-157 gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor... 303 4e-82 gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ... 302 7e-82 gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapi... 80 7e-15 gi|28212222 WFIKKN2 protein [Homo sapiens] 68 3e-11 gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sap... 64 7e-10 gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sap... 64 7e-10 gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 ... 62 2e-09 gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 p... 62 2e-09 gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 ... 62 2e-09 gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09 gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP... 62 2e-09 gi|73760409 tissue factor pathway inhibitor isoform b precursor ... 62 3e-09 gi|5454114 tissue factor pathway inhibitor isoform a precursor [... 62 3e-09 gi|145309328 papilin [Homo sapiens] 61 4e-09 gi|7662316 HIV-1 Vpr binding protein [Homo sapiens] 60 8e-09 gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo s... 58 4e-08 gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo s... 58 4e-08 gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo ... 58 4e-08 gi|4503257 death-domain associated protein isoform a [Homo sapiens] 57 5e-08 gi|215422388 death-domain associated protein isoform a [Homo sap... 57 5e-08 gi|215422366 death-domain associated protein isoform b [Homo sap... 57 5e-08 >gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 [Homo sapiens] Length = 763 Score = 1549 bits (4010), Expect = 0.0 Identities = 763/763 (100%), Positives = 763/763 (100%) Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240 Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300 Query: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420 Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480 Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540 Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600 Query: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD Sbjct: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660 Query: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ Sbjct: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720 Query: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI Sbjct: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 >gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2 [Homo sapiens] Length = 751 Score = 1513 bits (3918), Expect = 0.0 Identities = 751/763 (98%), Positives = 751/763 (98%), Gaps = 12/763 (1%) Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240 Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300 Query: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420 Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480 Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540 Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600 Query: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660 PFHPFPALPENE GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD Sbjct: 601 PFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 648 Query: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ Sbjct: 649 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 708 Query: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI Sbjct: 709 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751 >gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3 [Homo sapiens] Length = 695 Score = 1196 bits (3094), Expect = 0.0 Identities = 632/764 (82%), Positives = 645/764 (84%), Gaps = 70/764 (9%) Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180 Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEE Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEE--------------------- 219 Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300 DE+EEE E+ ED D Y F + + E+ TE D D+ Sbjct: 220 -----------------DEEEEEEEDEEEDYDVYKSEFP-TEADLEDFTEAAVDEDDEDE 261 Query: 301 EITHDVKAVCSQEAMTGPCRAVMPR-WYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAV 359 E +V V R +Y+D KG G+ ++ V Sbjct: 262 EEGEEV---------------VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDV 306 Query: 360 CKAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 419 +PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA Sbjct: 307 ---KVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363 Query: 420 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 479 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL Sbjct: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423 Query: 480 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 539 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER Sbjct: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483 Query: 540 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 599 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF Sbjct: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543 Query: 600 HPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETL 659 HPFHPFPALPENE GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETL Sbjct: 544 HPFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETL 591 Query: 660 DVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKR 719 DVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKR Sbjct: 592 DVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKR 651 Query: 720 QYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 QYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI Sbjct: 652 QYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695 >gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4 [Homo sapiens] Length = 522 Score = 757 bits (1955), Expect = 0.0 Identities = 388/403 (96%), Positives = 390/403 (96%), Gaps = 12/403 (2%) Query: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420 K ++PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK Sbjct: 132 KCLVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 191 Query: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ Sbjct: 192 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 251 Query: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR Sbjct: 252 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 311 Query: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH Sbjct: 312 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 371 Query: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660 PFHPFPALPENE GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD Sbjct: 372 PFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 419 Query: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ Sbjct: 420 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 479 Query: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI Sbjct: 480 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 522 Score = 276 bits (706), Expect = 5e-74 Identities = 135/135 (100%), Positives = 135/135 (100%) Query: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN Sbjct: 1 MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60 Query: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK Sbjct: 61 MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120 Query: 121 KQCKSRFVTPFKCLV 135 KQCKSRFVTPFKCLV Sbjct: 121 KQCKSRFVTPFKCLV 135 >gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sapiens] Length = 751 Score = 755 bits (1950), Expect = 0.0 Identities = 403/779 (51%), Positives = 527/779 (67%), Gaps = 64/779 (8%) Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74 L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56 Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132 +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++ Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116 Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192 CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+ Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176 Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251 D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236 Query: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 +E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V Sbjct: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290 Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPL 369 CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + IP T Sbjct: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAA 350 Query: 370 PTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQ 428 T D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ Sbjct: 351 STPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKK 410 Query: 429 TLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHR 488 +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP Sbjct: 411 AVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRH 470 Query: 489 ILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLY 548 + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY Sbjct: 471 VFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLY 530 Query: 549 KVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---V 588 VP VA+EIQ+E+DELLQ+++ A+M D S++ET V V Sbjct: 531 NVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPV 590 Query: 589 SSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINS 645 + E S +++ P+H F PA ENE +P P GL + + I S Sbjct: 591 NGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI-S 648 Query: 646 KNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAV 703 + K+D D +V ++++F AE VG + A+IGL+V V Sbjct: 649 EVKMDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGGV 691 Query: 704 AIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762 IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ Sbjct: 692 VIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750 >gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sapiens] Length = 770 Score = 744 bits (1920), Expect = 0.0 Identities = 402/798 (50%), Positives = 528/798 (66%), Gaps = 83/798 (10%) Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74 L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56 Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132 +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++ Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116 Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192 CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+ Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176 Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251 D+F G E+VCCP + +V + EED+ + + DY D + + A+ E+ E Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236 Query: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 +E DDED+E+G+EV E+ + Y+ E T + T + + + V+ V Sbjct: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREV 290 Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP---- 365 CS++A TGPCRA++ RWYFD+++GKC F YGGCGGNRNNF++E+YCMAVC + + Sbjct: 291 CSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLL 350 Query: 366 ----------PTPLPT------NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVK 409 P LPT + VD Y ET D+NEHA FQKAKE+LE +HR RM +V Sbjct: 351 KTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVM 410 Query: 410 KEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRR 469 +EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR Sbjct: 411 REWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRR 470 Query: 470 MALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQV 529 +ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQV Sbjct: 471 LALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQV 530 Query: 530 MTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM---------- 572 MTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ A+M Sbjct: 531 MTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGN 590 Query: 573 DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGS 626 D S++ET V V+ E S +++ P+H F PA ENE +P P Sbjct: 591 DALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRG 649 Query: 627 GVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPL 684 GL + + I S+ K+D D +V ++++F AE VG Sbjct: 650 LTTRPGSGLTNIKTEEI-SEVKMDAEFRHDSGYEVHHQKLVFFAEDVGS----------- 697 Query: 685 REDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNK 744 + A+IGL+V V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+K Sbjct: 698 ------NKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSK 751 Query: 745 MQNHGYENPTYKYLEQMQ 762 MQ +GYENPTYK+ EQMQ Sbjct: 752 MQQNGYENPTYKFFEQMQ 769 >gi|209915573 amyloid beta A4 protein isoform f precursor [Homo sapiens] Length = 714 Score = 659 bits (1700), Expect = 0.0 Identities = 357/720 (49%), Positives = 473/720 (65%), Gaps = 75/720 (10%) Query: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150 E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+ Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78 Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210 F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP + Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138 Query: 211 SVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDE--DDEDEEEGEEV 267 +V + EED+ + + DY D + + A+ E+ E +E DDED+E+G+EV Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198 Query: 268 VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWY 327 E+ + Y+ E T + T + + + V+ VCS++A TGPCRA++ RWY Sbjct: 199 EEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWY 252 Query: 328 FDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIP--------------PTPLPT-- 371 FD+++GKC F YGGCGGNRNNF++E+YCMAVC + + P LPT Sbjct: 253 FDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTA 312 Query: 372 ----NDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAER 427 + VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA++ Sbjct: 313 ASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADK 372 Query: 428 QTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPH 487 + +IQHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP Sbjct: 373 KAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPR 432 Query: 488 RILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLL 547 + L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLL Sbjct: 433 HVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLL 492 Query: 548 YKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR--- 587 Y VP VA+EIQ+E+DELLQ+++ A+M D S++ET V Sbjct: 493 YNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLP 552 Query: 588 VSSEES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVIN 644 V+ E S +++ P+H F PA ENE +P P GL + + I Sbjct: 553 VNGEFSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI- 610 Query: 645 SKNKVDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIA 702 S+ K+D D +V ++++F AE VG + A+IGL+V Sbjct: 611 SEVKMDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGG 653 Query: 703 VAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762 V IATVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ Sbjct: 654 VVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713 >gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sapiens] Length = 695 Score = 636 bits (1641), Expect = 0.0 Identities = 371/776 (47%), Positives = 474/776 (61%), Gaps = 114/776 (14%) Query: 15 LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74 L LLLL TA AL + NAG +AEPQIAMFCG+LNMH+N+Q GKW+ DP Sbjct: 5 LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56 Query: 75 TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132 +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++ Sbjct: 57 SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116 Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192 CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+ Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176 Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEA 252 D+F G E+VCCP EE + + + EE+D DV+ T D D +E Sbjct: 177 DKFRGVEFVCCPLA-----------EESDNVDSADAEEDDSDVWWGGADT--DYADGSED 223 Query: 253 AVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQ 312 V E E+EE E E+ D D GD+ EE EP + T I Sbjct: 224 KVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE- 281 Query: 313 EAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTN 372 S + VR +P T T Sbjct: 282 ------------------SVEEVVR--------------------------VPTTAASTP 297 Query: 373 D-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLI 431 D VD Y ET D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +I Sbjct: 298 DAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVI 357 Query: 432 QHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQ 491 QHFQ V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP + Sbjct: 358 QHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFN 417 Query: 492 ALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVP 551 L++YVRAE KDR HT++H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP Sbjct: 418 MLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVP 477 Query: 552 YVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSE 591 VA+EIQ+E+DELLQ+++ A+M D S++ET V V+ E Sbjct: 478 AVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGE 537 Query: 592 ES-EEIPPFHPF--HPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNK 648 S +++ P+H F PA ENE +P P GL + + I S+ K Sbjct: 538 FSLDDLQPWHSFGADSVPANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI-SEVK 595 Query: 649 VDENMVIDETLDV--KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIA 706 +D D +V ++++F AE VG + A+IGL+V V IA Sbjct: 596 MDAEFRHDSGYEVHHQKLVFFAEDVGS-----------------NKGAIIGLMVGGVVIA 638 Query: 707 TVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762 TVIVI+LVML+K+QY +I HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ Sbjct: 639 TVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694 >gi|209915570 amyloid beta A4 protein isoform e precursor [Homo sapiens] Length = 639 Score = 551 bits (1421), Expect = e-157 Identities = 326/698 (46%), Positives = 419/698 (60%), Gaps = 106/698 (15%) Query: 93 EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150 E+YPELQITNV+EANQ V+I NWC+R +KQCK+ FV P++CLVGEFVSD LLVP+KC+ Sbjct: 19 EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78 Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210 F H+ERM+VCE H HWHTV KE C + L+ YGMLLPCG+D+F G E+VCCP Sbjct: 79 FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLA---- 134 Query: 211 SVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVED 270 EE + + + EE+D DV+ T D D +E V E E+EE E E+ Sbjct: 135 -------EESDNVDSADAEEDDSDVWWGGADT--DYADGSEDKVVEVAEEEEVAEVEEEE 185 Query: 271 RDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDL 330 D D GD+ EE EP + T I Sbjct: 186 ADDDEDDEDGDEVEEE-AEEPYEEATERTTSIATTTTTTTE------------------- 225 Query: 331 SKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTND-VDVYFETSADDNEHAR 389 S + VR +P T T D VD Y ET D+NEHA Sbjct: 226 SVEEVVR--------------------------VPTTAASTPDAVDKYLETPGDENEHAH 259 Query: 390 FQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEK 449 FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQHFQ V++LE+EAA+E+ Sbjct: 260 FQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANER 319 Query: 450 QQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIR 509 QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP + L++YVRAE KDR HT++ Sbjct: 320 QQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLK 379 Query: 510 HYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR 569 H++HV VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++ Sbjct: 380 HFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQ 439 Query: 570 -------ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHPF--HPFP 606 A+M D S++ET V V+ E S +++ P+H F P Sbjct: 440 NYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVP 499 Query: 607 ALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV--KEM 664 A ENE +P P GL + + I S+ K+D D +V +++ Sbjct: 500 ANTENE-VEPVDARPAADRGLTTRPGSGLTNIKTEEI-SEVKMDAEFRHDSGYEVHHQKL 557 Query: 665 IFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTI 724 +F AE VG + A+IGL+V V IATVIVI+LVML+K+QY +I Sbjct: 558 VFFAEDVGS-----------------NKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSI 600 Query: 725 SHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 762 HG+VEVD +TPEERHL+KMQ +GYENPTYK+ EQMQ Sbjct: 601 HHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 638 >gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor [Homo sapiens] Length = 651 Score = 303 bits (776), Expect = 4e-82 Identities = 172/398 (43%), Positives = 243/398 (61%), Gaps = 33/398 (8%) Query: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423 + PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP Sbjct: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343 Query: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483 KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP Sbjct: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403 Query: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543 P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS Sbjct: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463 Query: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603 L LL + P++AQE++ +I ELL + + A SSE+ + P Sbjct: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP----- 512 Query: 604 PFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKE 663 P+++D PM G EQD S K N + V Sbjct: 513 -----PDSKDADT----PMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNA 553 Query: 664 MIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYG 722 + E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG Sbjct: 554 SVPRGFPFHSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYG 611 Query: 723 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQ 760 ISHG+VEVDPMLT EE+ L ++Q HGYENPTY++LE+ Sbjct: 612 AISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 649 Score = 188 bits (478), Expect = 1e-47 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%) Query: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 Query: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P Sbjct: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190 F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197 Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243 G D+F G EYVCC P +G S E EDEEE+ FP Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252 Query: 244 ADLEDFTEAAVDEDDED 260 D + F E E++E+ Sbjct: 253 VD-DYFVEPPQAEEEEE 268 >gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor [Homo sapiens] Length = 650 Score = 302 bits (774), Expect = 7e-82 Identities = 172/398 (43%), Positives = 243/398 (61%), Gaps = 34/398 (8%) Query: 364 IPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 423 + PTP PT+ VD+YF + +EH F +AK LE R +++ V +EW A+ Q+KNLP Sbjct: 284 VTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLP 343 Query: 424 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 483 KA+RQ L +HFQ++++ LE++ + E+Q+LVETH RV A++ND+RR ALE +LAALQ+DP Sbjct: 344 KADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADP 403 Query: 484 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 543 P+ R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER NQS Sbjct: 404 PQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQS 463 Query: 544 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 603 L LL + P++AQE++ +I ELL + + A SSE+ + P Sbjct: 464 LGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP----- 512 Query: 604 PFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKE 663 P+++D PM G EQD S K N + V Sbjct: 513 -----PDSKDDT-----PMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNA 552 Query: 664 MIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYG 722 + E +R+ + P +S A+ GLL++ ++IV+S+++L RK+ YG Sbjct: 553 SVPRGFPFHSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYG 610 Query: 723 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQ 760 ISHG+VEVDPMLT EE+ L ++Q HGYENPTY++LE+ Sbjct: 611 AISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEE 648 Score = 188 bits (478), Expect = 1e-47 Identities = 104/257 (40%), Positives = 143/257 (55%), Gaps = 23/257 (8%) Query: 15 LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73 L LLLL+ PA+ +LAG + G A Q+A CG+L +H +++TG+WEPD Sbjct: 24 LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77 Query: 74 PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130 P ++ C + VL+YC++MYPELQI V +A Q + ++ WC + C V P Sbjct: 78 PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137 Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190 F+CL GEFVS+ LLVPE C+F H+ERM+ CE+ H +EAC +QG+ L+ GMLLPC Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197 Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243 G D+F G EYVCC P +G S E EDEEE+ FP Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252 Query: 244 ADLEDFTEAAVDEDDED 260 D + F E E++E+ Sbjct: 253 VD-DYFVEPPQAEEEEE 268 >gi|10863909 serine protease inhibitor, Kunitz type, 2 [Homo sapiens] Length = 252 Score = 80.1 bits (196), Expect = 7e-15 Identities = 34/83 (40%), Positives = 46/83 (55%) Query: 288 PTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNR 347 P+ P + + + C+ A+TGPCRA PRWYFD+ + C FIYGGC GN+ Sbjct: 111 PSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNK 170 Query: 348 NNFESEDYCMAVCKAMIPPTPLP 370 N++ SE+ CM C PLP Sbjct: 171 NSYRSEEACMLRCFRQQENPPLP 193 Score = 62.0 bits (149), Expect = 2e-09 Identities = 22/51 (43%), Positives = 34/51 (66%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 C + G CRA MPRW+++++ G C F+YGGC GN NN+ +++ C+ C Sbjct: 38 CLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKC 88 >gi|28212222 WFIKKN2 protein [Homo sapiens] Length = 576 Score = 68.2 bits (165), Expect = 3e-11 Identities = 27/53 (50%), Positives = 34/53 (64%) Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 A CS A+ GPC+A PRW ++ G+C F+YGGC GN NNFES + C C Sbjct: 384 AACSLPALQGPCKAYAPRWAYNSQTGQCQSFVYGGCEGNGNNFESREACEESC 436 Score = 44.3 bits (103), Expect = 4e-04 Identities = 18/53 (33%), Positives = 26/53 (49%) Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 A C + + C RW+FD C+ F +G C N N+FE+ + CM C Sbjct: 326 AECLKPPDSEDCGEEQTRWHFDAQANNCLTFTFGHCHRNLNHFETYEACMLAC 378 >gi|4502067 alpha-1-microglobulin/bikunin preproprotein [Homo sapiens] Length = 352 Score = 63.5 bits (153), Expect = 7e-10 Identities = 28/53 (52%), Positives = 31/53 (58%) Query: 308 AVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 A C+ + GPCRA + W FD KGKCV F YGGC GN N F SE C C Sbjct: 285 AACNLPIVRGPCRAFIQLWAFDAVKGKCVLFPYGGCQGNGNKFYSEKECREYC 337 Score = 51.6 bits (122), Expect = 3e-06 Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 1/74 (1%) Query: 290 EPGSDGTMSDKEITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNN 349 E GS G E+T + C GPC + R++++ + C F YGGC GN NN Sbjct: 212 EEGSGGGQLVTEVTKKEDS-CQLGYSAGPCMGMTSRYFYNGTSMACETFQYGGCMGNGNN 270 Query: 350 FESEDYCMAVCKAM 363 F +E C+ C+ + Sbjct: 271 FVTEKECLQTCRTV 284 >gi|189571689 serine protease inhibitor, Kunitz type, 3 [Homo sapiens] Length = 89 Score = 63.5 bits (153), Expect = 7e-10 Identities = 25/53 (47%), Positives = 32/53 (60%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 VC+ GPC+ M RW+F+ G+C F YGGCGGN NNF ++ C CK Sbjct: 35 VCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKFCK 87 >gi|74027265 serine peptidase inhibitor, Kunitz type 1 isoform 2 precursor [Homo sapiens] Length = 513 Score = 62.4 bits (150), Expect = 2e-09 Identities = 25/57 (43%), Positives = 33/57 (57%) Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363 K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ + Sbjct: 372 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 428 Score = 61.6 bits (148), Expect = 3e-09 Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 6/118 (5%) Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249 Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPT 367 C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ + P+ Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGPS 307 >gi|4504329 serine peptidase inhibitor, Kunitz type 1 isoform 2 precursor [Homo sapiens] Length = 513 Score = 62.4 bits (150), Expect = 2e-09 Identities = 25/57 (43%), Positives = 33/57 (57%) Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363 K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ + Sbjct: 372 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 428 Score = 61.6 bits (148), Expect = 3e-09 Identities = 36/118 (30%), Positives = 58/118 (49%), Gaps = 6/118 (5%) Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249 Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPT 367 C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ + P+ Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGPS 307 >gi|32313599 serine peptidase inhibitor, Kunitz type 1 isoform 1 precursor [Homo sapiens] Length = 529 Score = 62.4 bits (150), Expect = 2e-09 Identities = 25/57 (43%), Positives = 33/57 (57%) Query: 307 KAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363 K C TG C+ +PRWY++ C RF YGGC GN+NNFE E C+ C+ + Sbjct: 388 KGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGI 444 Score = 60.5 bits (145), Expect = 6e-09 Identities = 35/114 (30%), Positives = 56/114 (49%), Gaps = 6/114 (5%) Query: 250 TEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 T+ V+ D ++ E + E + T D+ E+ T + +S K+ T D Sbjct: 196 TDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPED--TANVTVTVLSTKQ-TEDY--- 249 Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAM 363 C G CR PRWY+D ++ C F+YGGC GN+NN+ E+ C+ C+ + Sbjct: 250 CLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGV 303 >gi|31563528 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 isoform 2 [Homo sapiens] Length = 117 Score = 62.0 bits (149), Expect = 2e-09 Identities = 24/53 (45%), Positives = 30/53 (56%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 VC TGPC A W++D C F+YGGC GN NNF+S+ C+ CK Sbjct: 60 VCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCK 112 >gi|10732863 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 isoform 1 precursor [Homo sapiens] Length = 133 Score = 62.0 bits (149), Expect = 2e-09 Identities = 24/53 (45%), Positives = 30/53 (56%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 VC TGPC A W++D C F+YGGC GN NNF+S+ C+ CK Sbjct: 76 VCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCK 128 >gi|73760409 tissue factor pathway inhibitor isoform b precursor [Homo sapiens] Length = 251 Score = 61.6 bits (148), Expect = 3e-09 Identities = 24/51 (47%), Positives = 36/51 (70%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 C+ +A GPC+A+M R++F++ +C FIYGGC GN+N FES + C +C Sbjct: 54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104 Score = 50.8 bits (120), Expect = 5e-06 Identities = 21/52 (40%), Positives = 31/52 (59%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 C E G CR + R++++ +C RF YGGC GN NNFE+ + C +C+ Sbjct: 125 CFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICE 176 >gi|5454114 tissue factor pathway inhibitor isoform a precursor [Homo sapiens] Length = 304 Score = 61.6 bits (148), Expect = 3e-09 Identities = 24/51 (47%), Positives = 36/51 (70%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360 C+ +A GPC+A+M R++F++ +C FIYGGC GN+N FES + C +C Sbjct: 54 CAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104 Score = 55.1 bits (131), Expect = 2e-07 Identities = 25/52 (48%), Positives = 30/52 (57%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 C A G CRA R+Y++ GKC F Y GCGGN NNF S+ C+ CK Sbjct: 217 CLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACK 268 Score = 50.8 bits (120), Expect = 5e-06 Identities = 21/52 (40%), Positives = 31/52 (59%) Query: 310 CSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCK 361 C E G CR + R++++ +C RF YGGC GN NNFE+ + C +C+ Sbjct: 125 CFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICE 176 >gi|145309328 papilin [Homo sapiens] Length = 1251 Score = 60.8 bits (146), Expect = 4e-09 Identities = 30/70 (42%), Positives = 36/70 (51%), Gaps = 2/70 (2%) Query: 303 THDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKA 362 +H C + G C RWYF S G+C RF YGGC GN NNF SE CM+ C+ Sbjct: 720 SHAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQECMSSCQG 779 Query: 363 MI--PPTPLP 370 + P P P Sbjct: 780 SLHGPRRPQP 789 >gi|7662316 HIV-1 Vpr binding protein [Homo sapiens] Length = 1507 Score = 60.1 bits (144), Expect = 8e-09 Identities = 33/95 (34%), Positives = 50/95 (52%), Gaps = 7/95 (7%) Query: 215 EEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYY 274 E+EEED+EEEE+E+E++D D ++ E D + EA ++EDD +E GE+ D Sbjct: 1398 EDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDND---- 1453 Query: 275 YDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAV 309 F D N E G DG D + +V+ + Sbjct: 1454 ---FSPSDEELANLLEEGEDGEDEDSDADEEVELI 1485 Score = 35.0 bits (79), Expect = 0.26 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 28/98 (28%) Query: 212 VSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE-- 269 V ++ EDE+EEE+++EEE E+++D+E+ ++ + Sbjct: 1389 VGRQRLAEDEDEEEDQEEEEQ-----------------------EEEDDDEDDDDTDDLD 1425 Query: 270 --DRDYYYDTFKGDDYNEENPTEPG-SDGTMSDKEITH 304 D D + +D N EN E G +D + SD+E+ + Sbjct: 1426 ELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELAN 1463 >gi|55743106 alpha 3 type VI collagen isoform 5 precursor [Homo sapiens] Length = 2971 Score = 57.8 bits (138), Expect = 4e-08 Identities = 23/56 (41%), Positives = 31/56 (55%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364 +C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++ Sbjct: 2905 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 2960 >gi|55743098 alpha 3 type VI collagen isoform 1 precursor [Homo sapiens] Length = 3177 Score = 57.8 bits (138), Expect = 4e-08 Identities = 23/56 (41%), Positives = 31/56 (55%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364 +C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++ Sbjct: 3111 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 3166 >gi|240255535 alpha 3 type VI collagen isoform 4 precursor [Homo sapiens] Length = 2570 Score = 57.8 bits (138), Expect = 4e-08 Identities = 23/56 (41%), Positives = 31/56 (55%) Query: 309 VCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMI 364 +C G CR + +WY+D + C RF YGGCGGN N F S+ C VC ++ Sbjct: 2504 ICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVCAPVL 2559 >gi|4503257 death-domain associated protein isoform a [Homo sapiens] Length = 740 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%) Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262 CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+ Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481 Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301 E EE +D + E EPG + S E Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520 >gi|215422388 death-domain associated protein isoform a [Homo sapiens] Length = 740 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%) Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262 CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+ Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481 Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301 E EE +D + E EPG + S E Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520 >gi|215422366 death-domain associated protein isoform b [Homo sapiens] Length = 752 Score = 57.4 bits (137), Expect = 5e-08 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%) Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262 CP + +++EE DEEEEEEE+EEE+ E E DLE E EDDE+E+ Sbjct: 439 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 493 Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301 E EE +D + E EPG + S E Sbjct: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 532 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.132 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,187,195 Number of Sequences: 37866 Number of extensions: 1593729 Number of successful extensions: 34691 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 550 Number of HSP's successfully gapped in prelim test: 428 Number of HSP's that attempted gapping in prelim test: 15732 Number of HSP's gapped (non-prelim): 8630 length of query: 763 length of database: 18,247,518 effective HSP length: 110 effective length of query: 653 effective length of database: 14,082,258 effective search space: 9195714474 effective search space used: 9195714474 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.