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Search of human proteins with 4502123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502123 apoptotic peptidase activating factor 1 isoform b
[Homo sapiens]
(1194 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 2442 0.0
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 2434 0.0
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 2421 0.0
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 2413 0.0
gi|32483363 apoptotic peptidase activating factor 1 isoform e [H... 605 e-172
gi|32189425 WD repeat domain 69 [Homo sapiens] 118 3e-26
gi|23199987 WD repeat domain 5B [Homo sapiens] 117 9e-26
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 115 2e-25
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 115 2e-25
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 115 3e-25
gi|16554629 WD repeat domain 5 [Homo sapiens] 115 3e-25
gi|16554627 WD repeat domain 5 [Homo sapiens] 115 3e-25
gi|26665869 WD repeat domain 51B [Homo sapiens] 105 3e-22
gi|21536371 telomerase-associated protein 1 [Homo sapiens] 105 3e-22
gi|113865883 WD repeat domain 38 [Homo sapiens] 104 4e-22
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 103 7e-22
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 103 7e-22
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 101 4e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 100 6e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 100 6e-21
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 100 1e-20
gi|148727341 serine/threonine kinase receptor associated protein... 97 7e-20
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 95 5e-19
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 95 5e-19
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 95 5e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 90 1e-17
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 90 1e-17
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 90 1e-17
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 90 1e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens] 90 1e-17
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 2442 bits (6329), Expect = 0.0
Identities = 1194/1194 (100%), Positives = 1194/1194 (100%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
Query: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
Query: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
Query: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
Query: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
Query: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
Query: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
Query: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
Query: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 840
DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG
Sbjct: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 840
Query: 841 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG 900
SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG
Sbjct: 841 SSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTG 900
Query: 901 QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD 960
QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD
Sbjct: 901 QIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD 960
Query: 961 EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1020
EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT
Sbjct: 961 EKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIIT 1020
Query: 1021 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080
GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA
Sbjct: 1021 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080
Query: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS 1140
FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS 1140
Query: 1141 AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1141 AGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 2434 bits (6307), Expect = 0.0
Identities = 1194/1205 (99%), Positives = 1194/1205 (99%), Gaps = 11/1205 (0%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
Query: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
Query: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
Query: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
Query: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
Query: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
Query: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 829
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLS 840
Query: 830 WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 889
WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI
Sbjct: 841 WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900
Query: 890 RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 949
RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK
Sbjct: 901 RRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960
Query: 950 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1009
KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF
Sbjct: 961 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSF 1020
Query: 1010 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1069
DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL
Sbjct: 1021 DGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHEL 1080
Query: 1070 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1129
RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL
Sbjct: 1081 RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDL 1140
Query: 1130 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI
Sbjct: 1141 CFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
Query: 1190 LQTLE 1194
LQTLE
Sbjct: 1201 LQTLE 1205
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 2421 bits (6275), Expect = 0.0
Identities = 1194/1237 (96%), Positives = 1194/1237 (96%), Gaps = 43/1237 (3%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSVRTVLCEGGVPQRPVVFVTRKK 120
Query: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD
Sbjct: 121 LVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQD 180
Query: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL
Sbjct: 181 KSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVL 240
Query: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH
Sbjct: 241 KAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAH 300
Query: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS
Sbjct: 301 SIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSIS 360
Query: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK
Sbjct: 361 VEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGK 420
Query: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM
Sbjct: 421 SFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHM 480
Query: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN
Sbjct: 481 ASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLN 540
Query: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV
Sbjct: 541 GHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVV 600
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE
Sbjct: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF----------------------------- 811
DPQEDMEVIVKCCSWSADGARIMVAAKNKIF
Sbjct: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQ 840
Query: 812 --------------LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET
Sbjct: 841 NHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Query: 858 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 917
KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP
Sbjct: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
Query: 918 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 977
HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN
Sbjct: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
Query: 978 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1037
WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC
Sbjct: 1021 WQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSC 1080
Query: 1038 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1097
DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI
Sbjct: 1081 DISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1140
Query: 1098 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1157
RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ
Sbjct: 1141 RIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQ 1200
Query: 1158 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 TFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1237
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 2413 bits (6253), Expect = 0.0
Identities = 1194/1248 (95%), Positives = 1194/1248 (95%), Gaps = 54/1248 (4%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 349
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
Sbjct: 301 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD 360
Query: 350 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 409
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
Sbjct: 361 YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 420
Query: 410 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 469
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
Sbjct: 421 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC 480
Query: 470 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 529
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
Sbjct: 481 MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV 540
Query: 530 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 589
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
Sbjct: 541 SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK 600
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
Sbjct: 601 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 660
Query: 650 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
Sbjct: 661 LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 720
Query: 710 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 769
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
Sbjct: 721 SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS 780
Query: 770 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF------------------ 811
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF
Sbjct: 781 INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 840
Query: 812 -------------------------LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 846
LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
Sbjct: 841 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS 900
Query: 847 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 906
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
Sbjct: 901 SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 960
Query: 907 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 966
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
Sbjct: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020
Query: 967 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1026
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
Sbjct: 1021 SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD 1080
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1086
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
Sbjct: 1081 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1140
Query: 1087 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1146
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
Sbjct: 1141 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK 1200
Query: 1147 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1248
>gi|32483363 apoptotic peptidase activating factor 1 isoform e [Homo
sapiens]
Length = 338
Score = 605 bits (1559), Expect = e-172
Identities = 311/338 (92%), Positives = 315/338 (93%), Gaps = 14/338 (4%)
Query: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
Sbjct: 1 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI 60
Query: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS-----------VRTVLCEGGVP 109
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSS VRTVLCEGGVP
Sbjct: 61 LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP 120
Query: 110 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 169
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
Sbjct: 121 QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG 180
Query: 170 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 229
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
Sbjct: 181 GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL 240
Query: 230 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 289
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
Sbjct: 241 ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN 300
Query: 290 MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRW 327
MKKADLPEQAHSIIKECK +V +L D ++W
Sbjct: 301 MKKADLPEQAHSIIKECK---VVERCHWGILTDLLHKW 335
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 118 bits (296), Expect = 3e-26
Identities = 78/266 (29%), Positives = 125/266 (46%), Gaps = 33/266 (12%)
Query: 603 HTDAVYHACFSED-GQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
H + VY F+ G +IA+ DKT +++ ETG+ + H E++C +F+ +
Sbjct: 133 HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
AT S+D K+W+ GE V+T HS ++ F S ++ TGS D + +WD +
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADT 250
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
N + GH ++ F+ D L+ + S D T KLWDAT+ ++
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT---------- 300
Query: 782 PQEDMEVIVKCCSW--------SADG-ARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVH 832
D E++ C + SADG ARI AA +R +A GH +
Sbjct: 301 -GHDDEILDSCFDYTGKLIATASADGTARIFSAA----------TRKCIAKLEGHEGEIS 349
Query: 833 GVMFSPDGSSFLTSSDDQTIRLWETK 858
+ F+P G+ LT S D+T R+W+ +
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQ 375
Score = 105 bits (261), Expect = 3e-22
Identities = 89/378 (23%), Positives = 155/378 (41%), Gaps = 54/378 (14%)
Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
+KAH + A + T S D+ K+W++ +GE ++T + H V F N+ +
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-NNPY 146
Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
+ATGS D KLW + +C +T GHT + F+P L+A+ S D T KLWD
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSK 820
+ E ++ E+I S++ G RI+ + + + +W+ D+ K
Sbjct: 207 QNGEEVYTLR-----------GHSAEII--SLSFNTSGDRIITGSFDHTVVVWDADTGRK 253
Query: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 880
V GH + + F+ D S LT S D+T +LW+ A K + ++E
Sbjct: 254 VNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD--------ATNGKCVATLTGHDDE 305
Query: 881 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 940
++ D+ +L IA +G I +
Sbjct: 306 ILDSCFDYTGKL-----------------------------IATASADGTARIFSAATRK 336
Query: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRL- 998
H+ + I F L++ S D ++W+ Q +C+ L GH + +
Sbjct: 337 CIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN 396
Query: 999 LKNSRLLSWSFDGTVKVW 1016
K + +++ S D T ++W
Sbjct: 397 YKGNIVITGSKDNTCRIW 414
Score = 101 bits (251), Expect = 5e-21
Identities = 68/256 (26%), Positives = 119/256 (46%), Gaps = 16/256 (6%)
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
R HT + F+ +A+ D T +++ + GE++ ++ H E++ +F+T
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
I T S D V +W++ TG V+ H +++ F L+ TGS D KLWD
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS--LILTGSMDKTCKLWDAT 291
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLE 780
+C T+ GH + + F KL+A+ SADGT +++ SA RK I LE
Sbjct: 292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIF---SAATRKCI------AKLE 342
Query: 781 DPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPD 839
+ ++ I S++ G ++ + +K +W+ + + GH + F+
Sbjct: 343 GHEGEISKI----SFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYK 398
Query: 840 GSSFLTSSDDQTIRLW 855
G+ +T S D T R+W
Sbjct: 399 GNIVITGSKDNTCRIW 414
Score = 84.3 bits (207), Expect = 6e-16
Identities = 47/164 (28%), Positives = 85/164 (51%), Gaps = 6/164 (3%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
+R H+ + F+ G RI + D T+ V+ A+TG K+ + H E+ +F+ D
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCS 274
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLW 717
I T S+DK K+W++ G+ V T H +++ +C +T L+AT S+D +++
Sbjct: 275 LILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK----LIATASADGTARIF 330
Query: 718 DLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
++C + GH ++ F+P L + S+D T ++WDA
Sbjct: 331 SAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDA 374
Score = 77.4 bits (189), Expect = 7e-14
Identities = 64/301 (21%), Positives = 123/301 (40%), Gaps = 8/301 (2%)
Query: 825 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVM-- 882
+ H+ + V + GS F+T S D+T +LW+T + + + + V N
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 883 -VLAVDHIRRLQLINGRTGQIDYLTE---AQVSCCCLSPHLQYIAFGDENGAIEILELVN 938
+ + +L + TG+ + A++ C +P +A G + ++ ++ N
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 939 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFR 997
+ H + + F +I+ S D + VW+ + + L GH +
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
Query: 998 LLKN-SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAK 1056
+ S +L+ S D T K+W+ G H +L + ++ SAD TA+
Sbjct: 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTAR 328
Query: 1057 IWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSE 1116
I+S + +L GH G + +F+ L TG + RIW+ G+ L + ++
Sbjct: 329 IFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388
Query: 1117 E 1117
E
Sbjct: 389 E 389
Score = 76.3 bits (186), Expect = 2e-13
Identities = 67/297 (22%), Positives = 118/297 (39%), Gaps = 8/297 (2%)
Query: 812 LWNTDSRSKVADCRGHLSWVHGVMFS-PDGSSFLTSSDDQTIRLW--ETKKVCKNSAVML 868
LW+T S ++ GH + V+ + F+ P G T S D+T +LW ET K
Sbjct: 118 LWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
Query: 869 KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE---AQVSCCCLSPHLQYIAFG 925
+ V + F +V +L + + G+ Y A++ + I G
Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
Query: 926 DENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF 985
+ + + + R H + F D +++ S D ++W+ KC+
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297
Query: 986 -LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1043
L GH + + D +L++ S DGT ++++ T H+G + +
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
+ S+DKTA+IW L L GH + AF+ ++ TG + RIW
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/182 (21%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL-DKCIFLRGHQETVKD--FR 997
+F+ H + ++ I+ S D ++W+ ++ L GH+ V F
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 998 LLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKI 1057
++ + SFD T K+W++ TG F H ++ + +T ++ S D TAK+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKL 203
Query: 1058 WSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHL----CAP 1113
W ++ LRGH+ + +F+ + TG + + +W+ G +++ CA
Sbjct: 204 WDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Query: 1114 LS 1115
+S
Sbjct: 264 IS 265
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 117 bits (292), Expect = 9e-26
Identities = 72/258 (27%), Positives = 121/258 (46%), Gaps = 18/258 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + +S D R+ S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLII 141
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ VKIW TG+ + T HS+ V+ HF S L+ +GS D ++WD
Sbjct: 142 SGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS--LIVSGSYDGLCRIWDAASG 199
Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 200 QCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT---------- 249
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 839
E ++S G + +V+ N +++WN ++ V +GH V P
Sbjct: 250 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT 308
Query: 840 GSSFLTSS--DDQTIRLW 855
+ +++ +D+TI+LW
Sbjct: 309 ENLIASAALENDKTIKLW 326
Score = 109 bits (272), Expect = 2e-23
Identities = 81/304 (26%), Positives = 148/304 (48%), Gaps = 30/304 (9%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT+AV FS +G+ +AS AD+ + ++ A G+ + H E+ A+S+D +
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +K+W+ +G+ + T HS V CC+F S+ L+ +GS D +K+W++
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSN--LIISGSFDETVKIWEVKTG 157
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ L+ S S DG ++WDA S K++
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL------------ 205
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 839
+D V +S +G I+ A N + LW+ + GH + + + FS
Sbjct: 206 VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVT 265
Query: 840 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 890
G ++ S S+D + +W +TK++ + L+ DVV EN + A+++ +
Sbjct: 266 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISAACHPTENLIASAALENDK 321
Query: 891 RLQL 894
++L
Sbjct: 322 TIKL 325
Score = 86.7 bits (213), Expect = 1e-16
Identities = 74/304 (24%), Positives = 145/304 (47%), Gaps = 27/304 (8%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD + +W A K++ + NLE
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL----YGHNLE------ 85
Query: 787 EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 845
+ +WS+D +R++ A+ +K + LW+ S + +GH ++V F+P + ++
Sbjct: 86 ---ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIIS 142
Query: 846 SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ-I 902
S D+T+++WE K K K + V F + ++++ + ++ + +GQ +
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCL 202
Query: 903 DYLTE---AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QF 957
L + VS SP+ +YI + +++ + R ++ HK + I F
Sbjct: 203 KTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANF 262
Query: 958 T-ADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGT 1012
+ K ++S S+D + +WN Q + + L+GH + V L++ + D T
Sbjct: 263 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKT 322
Query: 1013 VKVW 1016
+K+W
Sbjct: 323 IKLW 326
Score = 80.9 bits (198), Expect = 7e-15
Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 24/280 (8%)
Query: 928 NGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW---NWQLDKCI 984
N + E+ E N + + H + V ++F+ + + L SSS D I +W + + +K +
Sbjct: 20 NQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTL 79
Query: 985 FLRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDA 1043
+ GH + D +SRL+S S D T+K+W++ +G K H V C+ + +
Sbjct: 80 Y--GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1103
S S D+T KIW L L H+ V F+ +L+ +G +G RIW+ +
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 1104 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA--GGYIKWWNVVTGESSQTFYT 1161
+G+ L V+ + FSP+GK +++A +K W+ G +T+
Sbjct: 198 SGQCLKTLVDDDNPP-------VSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-- 248
Query: 1162 NGTNLKKIHVSPDFK-------TYVTVDNLGILYILQTLE 1194
G +K + +F + DNL ++ LQT E
Sbjct: 249 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKE 288
Score = 71.6 bits (174), Expect = 4e-12
Identities = 46/166 (27%), Positives = 84/166 (50%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D+T+++++ +TG+ L + AH D V F+
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGS 180
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAT--LDNTLKLWD 238
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ C T GH N +C F+ K + S S D + +W+
Sbjct: 239 YSRGRCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 283
Score = 67.0 bits (162), Expect = 1e-10
Identities = 62/288 (21%), Positives = 118/288 (40%), Gaps = 13/288 (4%)
Query: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMV 883
GH V V FSP+G +SS D+ I +W K K + DV + + +
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 884 LAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNR 940
++ + L+L + R+G+ + V CC +P I G + ++I E+ +
Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
Query: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRL 998
++ H V + F ++S S D ++W+ +C+ + V +
Sbjct: 159 CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 999 LKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKT 1054
N + +L+ + D T+K+W+ G K + H+ + T S S D
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 278
Query: 1055 AKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1100
IW+ + +L+GH V +A L+A+ +++ I++W
Sbjct: 279 VYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/114 (31%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLC--CAFS-TDDRFIATCSVDK 668
FS +G+ I + D TL+++ G L H++E C FS T ++I + S D
Sbjct: 218 FSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDN 277
Query: 669 KVKIWNSMTGELVHTYDEHSEQV--NCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
V IWN T E+V H++ V CH T + + A +D +KLW N
Sbjct: 278 LVYIWNLQTKEIVQKLQGHTDVVISAACHPTENL--IASAALENDKTIKLWMSN 329
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 115 bits (289), Expect = 2e-25
Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 658
++ H+ AV ++ DG + S DKT+ V+ +ETGE++ +K H V C
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ + T S D VK+W+ + T+ +++ QV F ++S ++ +G D +K+WD
Sbjct: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
L Q + TM GH +SV S + L S + D T+++WD ++ VK F N
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 837
+ + ++++ CSWS DG++I + ++ +++W+T SR + GH ++ V F
Sbjct: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
Query: 838 PDGSSFLTSSDDQTIRLWE 856
PD +++S D+ + + E
Sbjct: 337 PDEPIIISASSDKRLYMGE 355
Score = 92.4 bits (228), Expect = 2e-18
Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)
Query: 639 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 696
++ + HE EV CC F + +A+ D+ + +WN + G+ + T HS V H+
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117
Query: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 753
+L + S+D + +WD E + GHT+ VN C R P +L+ + S D
Sbjct: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173
Query: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 813
GT+KLWD RK ++ F Q +V+ + ++D I N I +W
Sbjct: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220
Query: 814 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 873
+ RGH V G+ S +GS L+++ D T+R+W+ + K+
Sbjct: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274
Query: 874 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 933
+FQ N + E + C SP IA G + + +
Sbjct: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
Query: 934 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 973
+ + RI H ++ + F DE +IS+S D +
Sbjct: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
Score = 90.1 bits (222), Expect = 1e-17
Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 847
V CC + +G+ + A ++ I LWN A +GH V + ++ DGS ++S
Sbjct: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
Query: 848 DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 907
D+T+ +W+++ R++ + G T ++
Sbjct: 129 TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155
Query: 908 AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 967
SC Q + G ++G +++ ++ Q+ FQ+ V + F +IS
Sbjct: 156 ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211
Query: 968 SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1024
D +I+VW+ + +K + +RGH ++V L + S LLS + D TV+VW++ KE
Sbjct: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
Query: 1025 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1077
+ QG V L C S D +K ++ SAD+ +W L++L GH G +
Sbjct: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
Query: 1078 CSAFSVDSTLLATGDDN 1094
AF D ++ + +
Sbjct: 332 EVAFHPDEPIIISASSD 348
Score = 58.9 bits (141), Expect = 3e-08
Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)
Query: 907 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 965
E +V CC P+ +A + I + + + + + H V + + D L
Sbjct: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
Query: 966 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1022
S+S D + VW+ + + + L+GH V + L + S DGTVK+W+I
Sbjct: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
Query: 1023 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080
K+ Q T VL+ + + + S D K+W + +RGH V +
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
Query: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1139
S + + L + + +R+W+V C + + + +SPDG +
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
Query: 1140 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
SA ++ W+ + + ++ ++ PD ++ + LY+
Sbjct: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
Score = 38.1 bits (87), Expect = 0.050
Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)
Query: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
L P+ L GH G V C F + + LA+ + I +WNV C + AT
Sbjct: 55 LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
Query: 1122 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1154
H G V +L ++ DG ML SA + W+ TGE
Sbjct: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 115 bits (289), Expect = 2e-25
Identities = 72/253 (28%), Positives = 116/253 (45%), Gaps = 15/253 (5%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HTD + CF G ++A+ D T++++ G+ +L + H V C + + F+A
Sbjct: 393 HTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVA 452
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S+DK KIW+ + T H++ VN F S+ LL T S+D L +WD
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLL--TSSADKTLSIWDARTG 510
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
C +++GH +S+N F P ++ASC A G KLWD SI++ P
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDI--------GP 562
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
EV ++ + G + A+ N + ++ GH + H V+FS DG
Sbjct: 563 SPGNEV-----NFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEI 617
Query: 843 FLTSSDDQTIRLW 855
+ D T+R W
Sbjct: 618 LFSGGSDGTVRTW 630
Score = 73.9 bits (180), Expect = 8e-13
Identities = 71/312 (22%), Positives = 124/312 (39%), Gaps = 36/312 (11%)
Query: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC 738
+L + + H V+C H +L + D K+ L + T FGHT+ ++ C
Sbjct: 343 KLKNIFRLHELPVSCVSM--QPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDC 400
Query: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
F P LA+ S D T+KLWD + L E V C+W +
Sbjct: 401 CFHPSGDKLATSSGDTTVKLWDLCKGD---------CILTFEGHSR----AVWSCTWHSC 447
Query: 799 GARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
G + ++ +K +W+ +S GH V+ + F P ++ LTSS D+T+ +W+
Sbjct: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
Query: 858 KK-VCKNSAVMLKQEV-DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL 915
+ +C+ S + D +F M+ + D G T D+ + +
Sbjct: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDAC-------GVTKLWDFRKLLPIVSIDI 560
Query: 916 SPHL----------QYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLI 965
P + +A NG I +L+L + I H+ + F+ D + L
Sbjct: 561 GPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEILF 619
Query: 966 SSSDDAEIQVWN 977
S D ++ W+
Sbjct: 620 SGGSDGTVRTWS 631
Score = 72.4 bits (176), Expect = 2e-12
Identities = 64/290 (22%), Positives = 117/290 (40%), Gaps = 18/290 (6%)
Query: 864 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 923
S V ++ D++ E + V + + ++ G D+L++ CC P +A
Sbjct: 356 SCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSD-----CCFHPSGDKLA 410
Query: 924 FGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC 983
+ +++ +L + H + VW + + + SSS D ++W+ ++C
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Query: 984 -IFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISH 1041
L GH ++V S LL+ S D T+ +W+ TG E+ H ++
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
Query: 1042 DATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1101
+S A K+W F LLP+ + F +LA NG I + +
Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLD 590
Query: 1102 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWN 1149
+ +GE+ L H + FS DG++L S G G ++ W+
Sbjct: 591 LKSGEIHKLMG---------HENEAHTVVFSHDGEILFSGGSDGTVRTWS 631
Score = 59.7 bits (143), Expect = 2e-08
Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 16/208 (7%)
Query: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNS-R 1003
H+ V + + L+S +D +V L KC L GH + + D + +
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLG--LPKCNVLLTGFGHTDWLSDCCFHPSGDK 408
Query: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1063
L + S D TVK+W++ G+ F H V SC +S+S DKT+KIW +
Sbjct: 409 LATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE 468
Query: 1064 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
L GH V F S L T + + IW+ G + E+ H
Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--------ICEQSLYGHM 520
Query: 1124 GWVTDLCFSPDGKMLIS--AGGYIKWWN 1149
+ D F P G M+ S A G K W+
Sbjct: 521 HSINDAIFDPRGHMIASCDACGVTKLWD 548
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/163 (27%), Positives = 69/163 (42%), Gaps = 3/163 (1%)
Query: 597 RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFST 656
R + HTD+V F + + ADKTL ++ A TG + H + F
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
Query: 657 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
IA+C K+W+ + + D N +F +S +LA S + + L
Sbjct: 531 RGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGR--VLAQASGNGVIHL 588
Query: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
DL E M GH N + FS D ++L S +DGT++ W
Sbjct: 589 LDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/199 (23%), Positives = 80/199 (40%), Gaps = 2/199 (1%)
Query: 905 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 964
L E VSC + PH + E+ ++L L + + F H + F L
Sbjct: 350 LHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKL 409
Query: 965 ISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLK-NSRLLSWSFDGTVKVWNIITGN 1022
+SS D +++W+ CI GH V + + S S D T K+W++ +
Sbjct: 410 ATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSER 469
Query: 1023 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1082
H +V S + + ++SADKT IW + L GH + + F
Sbjct: 470 CRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFD 529
Query: 1083 VDSTLLATGDDNGEIRIWN 1101
++A+ D G ++W+
Sbjct: 530 PRGHMIASCDACGVTKLWD 548
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 115 bits (287), Expect = 3e-25
Identities = 72/278 (25%), Positives = 126/278 (45%), Gaps = 40/278 (14%)
Query: 602 PHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI 661
P T ++H FS + S D T++V+ ETG+ +K H D V +F + +
Sbjct: 110 PVTRVIFHPVFSV----MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 662 ATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
A+CS D +K+W+ E + T H V+ + H++ A S D +K+W++
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSA--SRDKTIKMWEVQT 223
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
C T GH V R + D L+ASCS D T+++W + + +
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL----------- 272
Query: 782 PQEDMEVIVKCCSWSAD--------------------GARIMVAAKNK-IFLWNTDSRSK 820
+ E +V+C SW+ + G ++ +++K I +W+ +
Sbjct: 273 --REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330
Query: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 858
+ GH +WV GV+F G L+ +DD+T+R+W+ K
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK 368
Score = 80.5 bits (197), Expect = 9e-15
Identities = 62/246 (25%), Positives = 102/246 (41%), Gaps = 30/246 (12%)
Query: 917 PHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 976
P + E+ I++ + ++ H +V I F K L S S D I++W
Sbjct: 118 PVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW 177
Query: 977 NWQLDKCI-FLRGHQETVKDFRLLKNS-RLLSWSFDGTVKVWNIITGNKEKDFVCHQGTV 1034
++Q +CI + GH V ++ N ++S S D T+K+W + TG K F H+ V
Sbjct: 178 DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWV 237
Query: 1035 LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST-------- 1086
+ D T +S S D+T ++W ELR H V C +++ +S+
Sbjct: 238 RMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEAT 297
Query: 1087 ------------LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPD 1134
L +G + I++W+VS G L H WV + F
Sbjct: 298 GSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG--------HDNWVRGVLFHSG 349
Query: 1135 GKMLIS 1140
GK ++S
Sbjct: 350 GKFILS 355
Score = 69.3 bits (168), Expect = 2e-11
Identities = 75/338 (22%), Positives = 137/338 (40%), Gaps = 45/338 (13%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--E 787
GH + V F P ++ S S D T+K+WD + + +++ K +++D D +
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL--KGHTDSVQDISFDHSGK 163
Query: 788 VIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 847
++ C +A I LW+ + GH V V P+G +++S
Sbjct: 164 LLASC------------SADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211
Query: 848 DDQTIRLWETKK-VCKNSAVMLKQEVDVVFQENEVMVLAV---DHIRRLQLINGRTGQID 903
D+TI++WE + C + ++ V +V + ++A D R+ ++ + + +
Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE 271
Query: 904 YLT-EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 962
E V C +P Y + + G+ + KK+ F
Sbjct: 272 LREHEHVVECISWAPESSYSSISEATGS----------------ETKKSGKPGPF----- 310
Query: 963 TLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1020
L+S S D I++W+ C+ L GH V+ + +LS + D T++VW+
Sbjct: 311 -LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKN 369
Query: 1021 GNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1058
K H+ V S D A + S D+T K+W
Sbjct: 370 KRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 60.8 bits (146), Expect = 7e-09
Identities = 66/303 (21%), Positives = 120/303 (39%), Gaps = 29/303 (9%)
Query: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQENEVMV 883
GH S V V+F P S +++S+D TI++W ET + D+ F + ++
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 884 LAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELVNNR 940
+ ++L + + + VS + P+ +I + I++ E+
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGY 225
Query: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLL 999
++ H++ V ++ D + S S+D ++VW +C LR H+ V+
Sbjct: 226 CVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWA 285
Query: 1000 KNSR---------------------LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1038
S LLS S D T+K+W++ TG V H V
Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGV- 344
Query: 1039 ISHDATKFSSTSAD-KTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEI 1097
+ H KF + AD KT ++W + + L H V F + + TG + +
Sbjct: 345 LFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTV 404
Query: 1098 RIW 1100
++W
Sbjct: 405 KVW 407
Score = 58.9 bits (141), Expect = 3e-08
Identities = 40/155 (25%), Positives = 66/155 (42%), Gaps = 10/155 (6%)
Query: 1002 SRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1061
S ++S S D T+KVW+ TG+ E+ H +V H +S SAD T K+W F
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180
Query: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
+ + GH+ V A + + + + I++W V G + +
Sbjct: 181 GFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCV--------KTFTG 232
Query: 1122 HGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGE 1154
H WV + + DG ++ S ++ W V T E
Sbjct: 233 HREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE 267
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/81 (30%), Positives = 39/81 (48%)
Query: 593 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC 652
T + + + H + V F G+ I SC DKTL+V+ + + + AHE V
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSL 386
Query: 653 AFSTDDRFIATCSVDKKVKIW 673
F ++ T SVD+ VK+W
Sbjct: 387 DFHKTAPYVVTGSVDQTVKVW 407
Score = 35.8 bits (81), Expect = 0.25
Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 10/110 (9%)
Query: 1067 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1126
+ L GH V F +++ + ++ I++W+ G+ E H V
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF--------ERTLKGHTDSV 153
Query: 1127 TDLCFSPDGKML--ISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1174
D+ F GK+L SA IK W+ E +T + + N+ + + P+
Sbjct: 154 QDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 115 bits (287), Expect = 3e-25
Identities = 82/304 (26%), Positives = 150/304 (49%), Gaps = 30/304 (9%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 839
+ + +S +G I+ A N + LW+ + GH + + + FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 840 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 890
G ++ S S+D + +W +TK++ + L+ DVV EN + A+++ +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAALENDK 325
Query: 891 RLQL 894
++L
Sbjct: 326 TIKL 329
Score = 114 bits (284), Expect = 7e-25
Identities = 68/260 (26%), Positives = 121/260 (46%), Gaps = 18/260 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 839
E ++S G + +V+ N +++WN ++ V +GH V P
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 840 GSSFLTSS--DDQTIRLWET 857
+ +++ +D+TI+LW++
Sbjct: 313 ENIIASAALENDKTIKLWKS 332
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 23/223 (10%)
Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
+ H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDS--- 817
+ K++ DP V ++ DG+ I+ ++ + + +W+T S
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 818 -RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 859
++ + D +S+ V FSP+G L ++ D T++LW+ K
Sbjct: 206 LKTLIDDDNPPVSF---VKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 74/345 (21%), Positives = 150/345 (43%), Gaps = 61/345 (17%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
Query: 787 EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 845
+WS+D ++ A+ +K + +W+ S + +GH ++V F+P + ++
Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 846 SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 903
S D+++R+W+ K K K V F + ++++ + ++ + +GQ
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-- 204
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
CL + D+N + ++F+ + K
Sbjct: 205 ----------CLKTLID-----DDNPPVSF---------------------VKFSPNGKY 228
Query: 964 LISSSDDAEIQVWNWQLDKCI-FLRGHQE----TVKDFRLLKNSRLLSWSFDGTVKVWNI 1018
+++++ D +++W++ KC+ GH+ +F + ++S S D V +WN+
Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Query: 1019 ITGNKEKDFVCHQGTVLS--CDISHDATKFSSTSADKTAKIWSFD 1061
T + H V+S C + + ++ DKT K+W D
Sbjct: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 986 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1044
L GH + V + N L S S D +K+W G EK H+ + S D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 1045 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1104
S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 1105 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1158
G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T
Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ +C T GH N +C F+ K + S S D + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 69.7 bits (169), Expect = 2e-11
Identities = 59/291 (20%), Positives = 123/291 (42%), Gaps = 19/291 (6%)
Query: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW-----ETKKVCKNSAVMLKQEVDVVFQENE 880
GH V V FSP+G +SS D+ I++W + +K + + DV + +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS---DVAWSSDS 99
Query: 881 VMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELV 937
++++ + L++ + +G+ + V CC +P I G + ++ I ++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 938 NNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKD 995
+ ++ H V + F D ++SSS D ++W+ +C+ + V
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 996 FRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSA 1051
+ N + +L+ + D T+K+W+ G K + H+ + T S S
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 1052 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1100
D IW+ + +L+GH V +A ++A+ +++ I++W
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.0 bits (136), Expect = 1e-07
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 1030 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1088
H V S S + +S+SADK KIW ++D + GH + A+S DS LL
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
Query: 1089 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1146
+ D+ ++IW+VS+G+ L + H +V F+P +++S ++
Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 1147 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1192
W+V TG+ +T + + +H + D V+ G+ I T
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 115 bits (287), Expect = 3e-25
Identities = 82/304 (26%), Positives = 150/304 (49%), Gaps = 30/304 (9%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D +
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+
Sbjct: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
Query: 783 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVM--FSPD 839
+ + +S +G I+ A N + LW+ + GH + + + FS
Sbjct: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
Query: 840 GSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAVDHIR 890
G ++ S S+D + +W +TK++ + L+ DVV EN + A+++ +
Sbjct: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAALENDK 325
Query: 891 RLQL 894
++L
Sbjct: 326 TIKL 329
Score = 114 bits (284), Expect = 7e-25
Identities = 68/260 (26%), Positives = 121/260 (46%), Gaps = 18/260 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD
Sbjct: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
Query: 723 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
Query: 782 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLWNTDSRSKVADCRGHLSWVHGVMFSPD 839
E ++S G + +V+ N +++WN ++ V +GH V P
Sbjct: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
Query: 840 GSSFLTSS--DDQTIRLWET 857
+ +++ +D+TI+LW++
Sbjct: 313 ENIIASAALENDKTIKLWKS 332
Score = 93.2 bits (230), Expect = 1e-18
Identities = 61/223 (27%), Positives = 112/223 (50%), Gaps = 23/223 (10%)
Query: 642 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 701
+ H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 702 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD
Sbjct: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDS--- 817
+ K++ DP V ++ DG+ I+ ++ + + +W+T S
Sbjct: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
Query: 818 -RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 859
++ + D +S+ V FSP+G L ++ D T++LW+ K
Sbjct: 206 LKTLIDDDNPPVSF---VKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 85.1 bits (209), Expect = 4e-16
Identities = 74/345 (21%), Positives = 150/345 (43%), Gaps = 61/345 (17%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
Query: 787 EVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLT 845
+WS+D ++ A+ +K + +W+ S + +GH ++V F+P + ++
Sbjct: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 846 SSDDQTIRLWETK--KVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 903
S D+++R+W+ K K K V F + ++++ + ++ + +GQ
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ-- 204
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
CL + D+N + ++F+ + K
Sbjct: 205 ----------CLKTLID-----DDNPPVSF---------------------VKFSPNGKY 228
Query: 964 LISSSDDAEIQVWNWQLDKCI-FLRGHQE----TVKDFRLLKNSRLLSWSFDGTVKVWNI 1018
+++++ D +++W++ KC+ GH+ +F + ++S S D V +WN+
Sbjct: 229 ILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Query: 1019 ITGNKEKDFVCHQGTVLS--CDISHDATKFSSTSADKTAKIWSFD 1061
T + H V+S C + + ++ DKT K+W D
Sbjct: 289 QTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
Score = 80.1 bits (196), Expect = 1e-14
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 986 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1044
L GH + V + N L S S D +K+W G EK H+ + S D+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 1045 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1104
S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 1105 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1158
G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T
Sbjct: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
Score = 73.2 bits (178), Expect = 1e-12
Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
Query: 660 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
Query: 719 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 760
++ +C T GH N +C F+ K + S S D + +W+
Sbjct: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
Score = 69.7 bits (169), Expect = 2e-11
Identities = 59/291 (20%), Positives = 123/291 (42%), Gaps = 19/291 (6%)
Query: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLW-----ETKKVCKNSAVMLKQEVDVVFQENE 880
GH V V FSP+G +SS D+ I++W + +K + + DV + +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS---DVAWSSDS 99
Query: 881 VMVLAVDHIRRLQLINGRTGQIDYLTEAQ---VSCCCLSPHLQYIAFGDENGAIEILELV 937
++++ + L++ + +G+ + V CC +P I G + ++ I ++
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
Query: 938 NNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKD 995
+ ++ H V + F D ++SSS D ++W+ +C+ + V
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
Query: 996 FRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATK---FSSTSA 1051
+ N + +L+ + D T+K+W+ G K + H+ + T S S
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
Query: 1052 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG--DDNGEIRIW 1100
D IW+ + +L+GH V +A ++A+ +++ I++W
Sbjct: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 57.0 bits (136), Expect = 1e-07
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 1030 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1088
H V S S + +S+SADK KIW ++D + GH + A+S DS LL
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
Query: 1089 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1146
+ D+ ++IW+VS+G+ L + H +V F+P +++S ++
Sbjct: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 1147 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1192
W+V TG+ +T + + +H + D V+ G+ I T
Sbjct: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 105 bits (262), Expect = 3e-22
Identities = 68/256 (26%), Positives = 111/256 (43%), Gaps = 16/256 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H D V FS G +AS D+T++++ + K E KAH V FS D +F+A
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLA 118
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK +K+W+ +++ H+ V C F+ L+ + S D +K+WD K
Sbjct: 119 TASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR--LIVSCSEDKTIKIWDTTNK 176
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+C N N F+P +AS +D T+K+WD + V + + +
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWD---------VRVNKLLQHYQVH 227
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGS 841
V C S+ G ++ A+ + + + + + +GH V V FS G
Sbjct: 228 SGG----VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGE 283
Query: 842 SFLTSSDDQTIRLWET 857
F + D + LW T
Sbjct: 284 LFASGGADTQVLLWRT 299
Score = 95.9 bits (237), Expect = 2e-19
Identities = 71/286 (24%), Positives = 124/286 (43%), Gaps = 23/286 (8%)
Query: 705 LATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
LAT S D FL LW+ GH + V +FSP LLAS S D T++LW
Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKR 92
Query: 765 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVAD 823
+ V+ +SADG + A+++K I +W+ + +
Sbjct: 93 GKFSEFKAH-------------TAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 824 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE-TKKVCKNS---AVMLKQEVDVVFQEN 879
H WV FSPDG ++ S+D+TI++W+ T K C N+ +V VD F +
Sbjct: 140 LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD--FNPS 197
Query: 880 EVMVLAVDHIRRLQLINGRTGQI---DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILEL 936
+ + + +++ + R ++ + V+C P Y+ +G ++IL+L
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDL 257
Query: 937 VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 982
+ R+ + H V+ + F+ + S D ++ +W D+
Sbjct: 258 LEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDE 303
Score = 92.8 bits (229), Expect = 2e-18
Identities = 61/253 (24%), Positives = 114/253 (45%), Gaps = 16/253 (6%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H A+ S +G+++A+ D L ++ + + H+D V FS +A
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D+ V++W + H+ V F S+ LAT S D +K+W + ++
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMYRQ 134
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+++ HT+ V +FSPD +L+ SCS D T+K+WD T+ + + F N D
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVD- 193
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGS 841
++ G I A ++ + +W+ + + H V+ + F P G+
Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
Query: 842 SFLTSSDDQTIRL 854
+T+S D T+++
Sbjct: 242 YLITASSDGTLKI 254
Score = 92.4 bits (228), Expect = 2e-18
Identities = 67/251 (26%), Positives = 114/251 (45%), Gaps = 12/251 (4%)
Query: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR-GHQETVKDFRLLKNSRLL- 1005
HK + + + + K L ++S D + +WN++ + GH++ V + + LL
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 1006 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1065
S S D TV++W K +F H V S D S D ++ S DK+ K+WS
Sbjct: 77 SASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRF 136
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
L+ L H VRC+ FS D L+ + ++ I+IW+ +N + ++ + G+
Sbjct: 137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN--------NFSDSVGF 188
Query: 1126 VTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1183
+ F+P G + SAG +K W+V + Q + + + I P +T +
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASS 248
Query: 1184 LGILYILQTLE 1194
G L IL LE
Sbjct: 249 DGTLKILDLLE 259
Score = 88.6 bits (218), Expect = 3e-17
Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 2/160 (1%)
Query: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
+ HT V FS DGQ +A+ DK+++V+ L + H V C FS D R
Sbjct: 99 KAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRL 158
Query: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
I +CS DK +KIW++ + V+ + + N F S +A+ SD +K+WD+
Sbjct: 159 IVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSG--TCIASAGSDQTVKVWDVR 216
Query: 721 QKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ VN F P L + S+DGTLK+ D
Sbjct: 217 VNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILD 256
Score = 84.3 bits (207), Expect = 6e-16
Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 50/350 (14%)
Query: 825 RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVL 884
+GH + + + SP+G T+S D + LW K
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP------------------------- 49
Query: 885 AVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQS 944
H R + + G D +T Q SPH +A + + + F
Sbjct: 50 ---HARAYRYV----GHKDVVTSVQ-----FSPHGNLLASASRDRTVRLWIPDKRGKFSE 97
Query: 945 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1003
H V + F+AD + L ++S+D I+VW+ + ++ L H V+ + + R
Sbjct: 98 FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGR 157
Query: 1004 LL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1062
L+ S S D T+K+W+ +F G D + T +S +D+T K+W +
Sbjct: 158 LIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRV 217
Query: 1063 LLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATH 1122
L + H+G V C +F L T +G ++I ++ G L++ H
Sbjct: 218 NKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYT--------LQGH 269
Query: 1123 GGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIH 1170
G V + FS G++ S G + W E T NLK++H
Sbjct: 270 TGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHCKGLTK-RNLKRLH 318
Score = 57.4 bits (137), Expect = 8e-08
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 2/112 (1%)
Query: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
F+ G IAS G+D+T++V+ + L + H V C +F ++ T S D +K
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
I + + G L++T H+ V F+ L A+G +D + LW N E
Sbjct: 254 ILDLLEGRLIYTLQGHTGPVFTVSFSKGGE--LFASGGADTQVLLWRTNFDE 303
Score = 45.4 bits (106), Expect = 3e-04
Identities = 38/180 (21%), Positives = 62/180 (34%), Gaps = 52/180 (28%)
Query: 1024 EKDFVCHQGTVLSCDISHDATK-------------------------------------- 1045
E+ F H+ + S D+S + +
Sbjct: 11 ERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70
Query: 1046 ----FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN 1101
+S S D+T ++W D E + H VR FS D LAT ++ I++W+
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130
Query: 1102 VSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1159
+ L+ H WV FSPDG++++S IK W+ + F
Sbjct: 131 MYRQRFLY--------SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNF 182
Score = 36.2 bits (82), Expect = 0.19
Identities = 23/101 (22%), Positives = 39/101 (38%), Gaps = 1/101 (0%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H+ V F G + + +D TL++ G + ++ H V +FS A
Sbjct: 227 HSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFA 286
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
+ D +V +W + EL H + HF + H L
Sbjct: 287 SGGADTQVLLWRTNFDEL-HCKGLTKRNLKRLHFDSPPHLL 326
>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
Length = 2627
Score = 105 bits (261), Expect = 3e-22
Identities = 185/805 (22%), Positives = 300/805 (37%), Gaps = 175/805 (21%)
Query: 476 LAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEY-------RHILDEKDCA 528
L YH+ + L + +L + A EL + L+ Y L E D A
Sbjct: 1545 LPYHLLQSGNRGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVA 1604
Query: 529 VSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWIN 588
V F+ FL +L + P + Q +P S + QA L +++ + L W+N
Sbjct: 1605 V---FRTFLRQQASILSQYP-RLLPQQAANQPLDSPLCHQASLLSRRW--HLQHTLRWLN 1658
Query: 589 K----KNITNLS-RLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
K KN + S L V AV FS +GQR A A+ T+ + T ++ +
Sbjct: 1659 KPRTMKNQQSSSLSLAVSSSPTAV---AFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVV 1715
Query: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHL 703
+ D + C F +DD T + D +++W+ G V H Q+ C +
Sbjct: 1716 SGCDGISACLFLSDDTLFLT-AFDGLLELWDLQHGCRVLQTKAHQYQITGCCLSPDCR-- 1772
Query: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHT--NSVNHCRFSPDDKLLASCSADGTLKLWDA 761
LLAT LKLWD + + F HT S+N F P+ +++A+ S G++ +
Sbjct: 1773 LLATVCLGGCLKLWDTVRGQLA---FQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQV 1829
Query: 762 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSK 820
K + ++ +++ G + V + + LW ++
Sbjct: 1830 DGLKVTKDLGAPG-------------ASIRTLAFNVPGGVVAVGRLDSMVELWAWREGAR 1876
Query: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNS---AVMLKQEVDVVFQ 877
+A H +V +F G LT+ +D +++W ++ L + V
Sbjct: 1877 LAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALS 1936
Query: 878 ENEVMVLA---VDHIRRLQLINGRTGQIDYLTEAQVSCCC-LSPHLQYIAFGDENGAIEI 933
+ V D IR ++ +G G + VS LSP + + G E+G+++
Sbjct: 1937 PDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKV--LVSGAEDGSLQG 1994
Query: 934 LEL----VNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQL--------- 980
L + + SRFQ K V + ++ L S+S+D +Q+W QL
Sbjct: 1995 WALKECSLQSLWLLSRFQ--KPV--LGLATSQELLASASEDFTVQLWPRQLLTRPHKAED 2050
Query: 981 DKC-IFLRGHQETV----------------KDFRLL------------------------ 999
C LRGH+ V +D LL
Sbjct: 2051 FPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWV 2110
Query: 1000 ------KNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVL------------------ 1035
K++ L+S S DG+V +W+ +G + F+ HQ V
Sbjct: 2111 TGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTL 2170
Query: 1036 ----------------SCDISHDATKFSSTSA--------------DKTAKIWSFDLLLP 1065
S ISH A +A D ++W L+
Sbjct: 2171 KVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQ 2230
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
H L GH+G VR +A S S L+ T ++G +R+W V E C P S
Sbjct: 2231 THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPK-EADDTCIPRSSAA------- 2282
Query: 1126 VTDLCFSPDGKMLIS---AGGYIKW 1147
VT + ++PDG M +S AG I W
Sbjct: 2283 VTAVAWAPDGSMAVSGNQAGELILW 2307
Score = 66.2 bits (160), Expect = 2e-10
Identities = 67/323 (20%), Positives = 127/323 (39%), Gaps = 37/323 (11%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H D V +++D I SC +D ++ ++ E+G++L + H+ V A + + +
Sbjct: 2106 HRDWVTGCAWTKDNLLI-SCSSDGSVGLWDPESGQRLGQFLGHQSAV--SAVAAVEEHVV 2162
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT-------NSSHHLLLATGSSDCFLK 715
+ S D +K+W+ EL + HS ++ C LL+ T D +
Sbjct: 2163 SVSRDGTLKVWDHQGVELT-SIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATR 2221
Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
LW +T+ GH+ V S L+ + S DG+++LW + I
Sbjct: 2222 LWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCI----- 2276
Query: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAK-NKIFLWNTDSRSKVADCRGHLSWVHGV 834
P+ V +W+ DG+ + + ++ LW A GH+ G
Sbjct: 2277 ------PRS--SAAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHI----GA 2324
Query: 835 MFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQL 894
+ +F S D+ I W+ K ++ L ++ + QE+ ++ ++D
Sbjct: 2325 LIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDW------ 2378
Query: 895 INGRTGQIDYLTEAQVSCCCLSP 917
G L +A + C+ P
Sbjct: 2379 --APDGHFLILAKADLKLLCMKP 2399
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 104 bits (260), Expect = 4e-22
Identities = 63/254 (24%), Positives = 106/254 (41%), Gaps = 12/254 (4%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V + FS DGQ + + D + ++ +G+ L + H V C FS D A
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
+ S D V++W+ + + H V F+ S LA+G D + LWD+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ--LASGGWDKRVMLWDVQSG 137
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
+ + GH +S+ FSP LA+ S D T+ +WD S
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS----------HQA 187
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
E + C +SA G + I +W + S + +GH++WV + FSPD
Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELW 247
Query: 843 FLTSSDDQTIRLWE 856
++ + +++W+
Sbjct: 248 LASAGYSRMVKVWD 261
Score = 98.6 bits (244), Expect = 3e-20
Identities = 74/257 (28%), Positives = 120/257 (46%), Gaps = 16/257 (6%)
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
+V+ SP Q + G E+G + E + ++ H V +F+ D S+S
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 969 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1026
D +++W+ KC+ L+GHQ +V+ +SR L S +D V +W++ +G +
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL---HELRGHNGCVRCSAFSV 1083
V H+ ++ S D S ++ S D T IW ++ P L GH+ + C +S
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSA 202
Query: 1084 DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG- 1142
S LLA+G + I IW + LL + +G H WV + FSPD L SAG
Sbjct: 203 -SGLLASGSWDKTIHIWKPTTSSLL-----IQLKG---HVTWVKSIAFSPDELWLASAGY 253
Query: 1143 -GYIKWWNVVTGESSQT 1158
+K W+ TG+ +T
Sbjct: 254 SRMVKVWDCNTGKCLET 270
Score = 85.9 bits (211), Expect = 2e-16
Identities = 66/255 (25%), Positives = 117/255 (45%), Gaps = 20/255 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT V FS DG AS D T++++ + L +K H+ V +FS D R +A
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA 121
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ- 721
+ DK+V +W+ +G+++ H + + F+ + + LATGS D + +WDL
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVN--CLATGSWDSTVHIWDLRMV 179
Query: 722 --KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
+ GH+ +++ C LLAS S D T+ +W T++ +L
Sbjct: 180 TPAVSHQALEGHSANIS-CLCYSASGLLASGSWDKTIHIWKPTTS-------------SL 225
Query: 780 EDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSP 838
+ VK ++S D + A ++ + +W+ ++ + +G L H F+P
Sbjct: 226 LIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTP 285
Query: 839 DGSSFLTSSDDQTIR 853
DG ++ + DQT R
Sbjct: 286 DGKILVSGAADQTRR 300
Score = 82.8 bits (203), Expect = 2e-15
Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 53/320 (16%)
Query: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
H V+ FSPDG LT S+D + WET+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-------------------------- 53
Query: 887 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946
+ L + G TG + + C SP A + + + ++ + +
Sbjct: 54 ---QLLWRLGGHTGPVKF--------CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLK 102
Query: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVK--DFRLLKNSR 1003
H+++V + F+ D + L S D + +W+ Q + + L GH+++++ DF N
Sbjct: 103 GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNC- 161
Query: 1004 LLSWSFDGTVKVWNI--ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1061
L + S+D TV +W++ +T + +SC + +S S DKT IW
Sbjct: 162 LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPT 221
Query: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
L +L+GH V+ AFS D LA+ + +++W+ + G+ L + +
Sbjct: 222 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD----- 276
Query: 1122 HGGWVTDLC-FSPDGKMLIS 1140
V C F+PDGK+L+S
Sbjct: 277 ----VAHTCAFTPDGKILVS 292
Score = 76.6 bits (187), Expect = 1e-13
Identities = 50/168 (29%), Positives = 81/168 (48%), Gaps = 6/168 (3%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H +V FS D +++AS G DK + ++ ++G+ L + H D + FS
Sbjct: 100 VLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTV 159
Query: 659 RFIATCSVDKKVKIWN--SMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
+AT S D V IW+ +T + H + HS ++C ++ S LLA+GS D +
Sbjct: 160 NCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG---LLASGSWDKTIH 216
Query: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATS 763
+W + GH V FSPD+ LAS +K+WD +
Sbjct: 217 IWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 264
Score = 72.4 bits (176), Expect = 2e-12
Identities = 62/233 (26%), Positives = 101/233 (43%), Gaps = 12/233 (5%)
Query: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL 1005
QH V F+ D + L++ S+D + W + + ++ L GH VK R + L
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 1006 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLL 1064
S S D TV++W++ + HQ +V + S D+ + +S DK +W
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 1065 PLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGG 1124
L L GH ++ S FS LATG + + IW +L + +S + H
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW-----DLRMVTPAVSHQALEGHSA 193
Query: 1125 WVTDLCFSPDGKMLISAGGY---IKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1174
++ LC+S G L+++G + I W T + T +K I SPD
Sbjct: 194 NISCLCYSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPD 244
Score = 66.6 bits (161), Expect = 1e-10
Identities = 60/307 (19%), Positives = 119/307 (38%), Gaps = 42/307 (13%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V ++S DG ++ +++ ++ W T S + GH V FSPDG F ++S
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASC 83
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D T+RLW+ + + L+++ G ++ ++
Sbjct: 84 DCTVRLWDVARA-----------------------------KCLRVLKGHQRSVETVS-- 112
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
SP + +A G + + + ++ + ++ + H+ ++ F+ L + S
Sbjct: 113 ------FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGS 166
Query: 969 DDAEIQVWNWQLDKCIF----LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKE 1024
D+ + +W+ ++ L GH + + L S S+D T+ +W T +
Sbjct: 167 WDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLL 226
Query: 1025 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1084
H V S S D +S + K+W + L L+G AF+ D
Sbjct: 227 IQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPD 286
Query: 1085 STLLATG 1091
+L +G
Sbjct: 287 GKILVSG 293
Score = 47.8 bits (112), Expect = 6e-05
Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 10/158 (6%)
Query: 1025 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1084
K F H G V S S D + S D W L L GH G V+ FS D
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 1085 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG-- 1142
L A+ + +R+W+V+ + L + H V + FSPD + L S G
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRV--------LKGHQRSVETVSFSPDSRQLASGGWD 126
Query: 1143 GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1180
+ W+V +G+ + + +++ SP T
Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164
Score = 35.4 bits (80), Expect = 0.33
Identities = 21/79 (26%), Positives = 38/79 (48%)
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV 649
K T+ + ++ H V FS D +AS G + ++V+ TG+ L +K D
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278
Query: 650 LCCAFSTDDRFIATCSVDK 668
CAF+ D + + + + D+
Sbjct: 279 HTCAFTPDGKILVSGAADQ 297
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 103 bits (258), Expect = 7e-22
Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
Y TE ++ +SP + +A G +N I++ L + ++ H+ V I D
Sbjct: 265 YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
Query: 964 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1022
++ DD + + LRGH V R L +S LLS S D +++ W++ +
Sbjct: 320 ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
Query: 1023 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1082
+ H V DIS + F+S S D+TA++WSFD PL GH V C F
Sbjct: 376 NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
Query: 1083 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142
+S LATG + +R+W+ G + L H G V L FSP+GK L SAG
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
Query: 1143 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1174
+K W++ +G + + N+ + SPD
Sbjct: 488 EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V+ S AS D+T +++ + L H +V C F + ++A
Sbjct: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK V++W++ G V + H V F+ + +L A+ D LKLWDL
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ GHT+++ FSPD L+AS S D ++++WD
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 77.8 bits (190), Expect = 6e-14
Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 18/267 (6%)
Query: 636 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 695
G ++ ++ H V F D + +CS D ++ W+ + Y H+ V
Sbjct: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
Query: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 755
S + L A+GS D +LW ++ GH V+ +F P+ LA+ S D T
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 756 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWN 814
++LW A N + F P V ++S +G + A ++ ++ LW+
Sbjct: 450 VRLWSAQQGNSVR------LFTGHRGP-------VLSLAFSPNGKYLASAGEDQRLKLWD 496
Query: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 873
S + + RGH + + FSPD ++S D ++R+W+ + C A E+
Sbjct: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
Query: 874 VVFQENEVMVLAVDHIR-RLQLINGRT 899
V+ VL+V + L L+ G T
Sbjct: 557 GVYTGQMSNVLSVQFMACNLLLVTGIT 583
Score = 76.3 bits (186), Expect = 2e-13
Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 2/172 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
++R H VY F D + SC D +++ + + + + H V S
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ A+ S D+ ++W+ + Y H V+C F +S++L ATGS+D ++LW
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSI 770
Q GH V FSP+ K LAS D LKLWD S K +
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
Score = 73.9 bits (180), Expect = 8e-13
Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)
Query: 837 SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 890
SPD D+ I+LW + S + D++ +E++ A ++
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
Query: 891 RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 949
L+ G +L ++ + C ++Y G N ++Q H
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
Query: 950 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1006
VW + + S S D ++W++ D+ LR GH V + NS L+
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
Query: 1007 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1065
S D TV++W+ GN + F H+G VLS S + +S D+ K+W
Sbjct: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1104
ELRGH + FS DS L+A+ + +R+W++ N
Sbjct: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 62.8 bits (151), Expect = 2e-09
Identities = 68/312 (21%), Positives = 113/312 (36%), Gaps = 81/312 (25%)
Query: 704 LLATGSSDCFLKLWDLNQKECRNT--------------------------------MFGH 731
LLA G + +KLW L K+ ++ + GH
Sbjct: 282 LLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGH 341
Query: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 791
V RF D L SCS D +++ WD S + P D++ I
Sbjct: 342 CGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAY------PVWDLD-ISP 394
Query: 792 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 851
+ A G+ A LW+ D + GHL+ V V F P+ + T S D+T
Sbjct: 395 YSLYFASGSHDRTAR-----LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 852 IRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVS 911
+RLW + Q N V +L G G + L
Sbjct: 450 VRLWSAQ------------------QGNSV-----------RLFTGHRGPVLSLA----- 475
Query: 912 CCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDA 971
SP+ +Y+A E+ +++ +L + +++ H + + F+ D + S+S D
Sbjct: 476 ---FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532
Query: 972 EIQVWNWQLDKC 983
++VW+ + C
Sbjct: 533 SVRVWDIRNTYC 544
Score = 53.9 bits (128), Expect = 9e-07
Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V FS +G+ +AS G D+ L+++ +G E++ H D + FS D IA
Sbjct: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526
Query: 663 TCSVDKKVKIW-----------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
+ S+D V++W + + ELV Y V F + +LLL TG
Sbjct: 527 SASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQF--MACNLLLVTG 581
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 103 bits (258), Expect = 7e-22
Identities = 100/400 (25%), Positives = 167/400 (41%), Gaps = 45/400 (11%)
Query: 724 CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 783
C +++ GH+ +V FSP K LAS S D T++ WD ++ + + +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHW------- 158
Query: 784 EDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVA-DCRGHLSWVHGVMF----- 836
V SWS DG ++ KN +I LW+ + +V GH W+ G+ +
Sbjct: 159 ------VLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHA 212
Query: 837 SPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 895
+P+ +SS D ++R+W+T C+ Q V + + ++ + R +++
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVW 272
Query: 896 NGRTGQIDYLTEAQVSCCCLSPHLQYIA-------FGDENGAIEILEL-VNNRIFQSRFQ 947
G V C L H ++ + GA E E VN + Q Q
Sbjct: 273 RAHDG---------VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQ 323
Query: 948 HKK----TVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR--GHQETVKDFRLLKN 1001
K + +++ + L+S SDD + +W+ DK R GHQ + +
Sbjct: 324 ELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD 383
Query: 1002 SRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1060
SR++ S SFD ++K+W+ TG H V S D+ S S+D T K+W
Sbjct: 384 SRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Query: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
+L GH V +S D +A+G + +RIW
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 83.6 bits (205), Expect = 1e-15
Identities = 72/291 (24%), Positives = 128/291 (43%), Gaps = 40/291 (13%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H++AV FS G+ +AS D T++ + T K H VL ++S D R +A
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 663 TCSVDKKVKIWNSMTGELV-HTYDEHSEQVNCCHFT---NSSHHLLLATGSSDCFLKLWD 718
+ + ++ +W+ TG+ V T HS+ + + + +A+ S D +++WD
Sbjct: 173 SGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWD 232
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA----------------- 761
C + GHT SV R+ D LL S S D T+K+W A
Sbjct: 233 TTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVN 291
Query: 762 -----------TSANE--RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 808
T A E S+N + +L++ +E + + G +V+ +
Sbjct: 292 TMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKE--RALSRYNLVRGQGPERLVSGSD 349
Query: 809 --KIFLWN-TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
+FLW+ + + + GH + ++ V+FSPD ++S D++I+LW+
Sbjct: 350 DFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400
Score = 79.7 bits (195), Expect = 2e-14
Identities = 65/280 (23%), Positives = 111/280 (39%), Gaps = 58/280 (20%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTG 678
+AS D +++++ G + H V C + D + + S D+ +K+W + G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDG 277
Query: 679 ELVHTYDEHSEQVNCCHFTN---------------------------------SSHHLL- 704
L T H VN + S ++L+
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337
Query: 705 ------LATGSSDCFLKLWD-LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLK 757
L +GS D L LW K+ M GH +N FSPD +++AS S D ++K
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397
Query: 758 LWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMV--AAKNKIFLWNT 815
LWD + S+ V +WSAD +R++V ++ + + +W+
Sbjct: 398 LWDGRTGKYLASL-------------RGHVAAVYQIAWSAD-SRLLVSGSSDSTLKVWDV 443
Query: 816 DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 855
++ D GH V+ V +SPDG + D+ +R+W
Sbjct: 444 KAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 74.3 bits (181), Expect = 6e-13
Identities = 46/153 (30%), Positives = 78/153 (50%), Gaps = 3/153 (1%)
Query: 608 YHACFSEDGQRIASCGADKTLQVFK-AETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSV 666
Y+ + +R+ S D TL ++ AE + L + H+ + FS D R +A+ S
Sbjct: 333 YNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 667 DKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRN 726
DK +K+W+ TG+ + + H V ++ S LL +GSSD LK+WD+ ++
Sbjct: 393 DKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAM 450
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
+ GH + V +SPD + +AS D L++W
Sbjct: 451 DLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 56.6 bits (135), Expect = 1e-07
Identities = 32/130 (24%), Positives = 63/130 (48%), Gaps = 7/130 (5%)
Query: 588 NKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHED 647
+KK +T ++ H + FS D + +AS DK+++++ TG+ L ++ H
Sbjct: 361 DKKPLTRMTG-----HQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVA 415
Query: 648 EVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLAT 707
V A+S D R + + S D +K+W+ +L H+++V ++ +A+
Sbjct: 416 AVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQR--VAS 473
Query: 708 GSSDCFLKLW 717
G D L++W
Sbjct: 474 GGKDKCLRIW 483
Score = 50.4 bits (119), Expect = 1e-05
Identities = 34/131 (25%), Positives = 56/131 (42%), Gaps = 14/131 (10%)
Query: 1030 HQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLA 1089
H V+S S +S S D T + W P +GH V ++S D LA
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLA 172
Query: 1090 TGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCF-----SPDGKMLISAG-- 1142
+G NG+I +W+ S G+ + A H W+T L + +P+ + + S+
Sbjct: 173 SGCKNGQILLWDPSTGKQV-------GRTLAGHSKWITGLSWEPLHANPECRYVASSSKD 225
Query: 1143 GYIKWWNVVTG 1153
G ++ W+ G
Sbjct: 226 GSVRIWDTTAG 236
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 16/132 (12%)
Query: 1069 LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTD 1128
L GH+ V AFS LA+G + +R W++S C H WV
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC--------KGHRHWVLS 161
Query: 1129 LCFSPDGKMLISA--GGYIKWWNVVTGE------SSQTFYTNGTNLKKIHVSPDFKTYVT 1180
+ +SPDG+ L S G I W+ TG+ + + + G + + +H +P+ + +
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 1181 VDNLGILYILQT 1192
G + I T
Sbjct: 222 SSKDGSVRIWDT 233
Score = 35.0 bits (79), Expect = 0.43
Identities = 15/30 (50%), Positives = 21/30 (70%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFK 632
H D VY +S DGQR+AS G DK L++++
Sbjct: 455 HADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 101 bits (252), Expect = 4e-21
Identities = 79/280 (28%), Positives = 124/280 (44%), Gaps = 20/280 (7%)
Query: 586 WINKKNITN--LSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
W ++ TN + + +R H+ V S DGQ S D TL+++ TG
Sbjct: 43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV 102
Query: 644 AHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHH 702
H +VL AFS+D+R I + S DK +K+WN++ DE HSE V+C F+ +S +
Sbjct: 103 GHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
++ + D +K+W+L + + GHT +N SPD L AS DG LWD
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
Query: 763 SANERKS------INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 816
+ IN F N +K W +G I+ K ++ +T
Sbjct: 223 EGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKI--WDLEGKIIVDELKQEVI--STS 278
Query: 817 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
S+++ C L+W S DG + D +R+W+
Sbjct: 279 SKAEPPQCTS-LAW------SADGQTLFAGYTDNLVRVWQ 311
Score = 79.7 bits (195), Expect = 2e-14
Identities = 60/208 (28%), Positives = 101/208 (48%), Gaps = 22/208 (10%)
Query: 964 LISSSDDAEIQVWNWQLDKCIF------LRGHQETVKDFRLLKNSRL-LSWSFDGTVKVW 1016
++S+S D I +W D+ + LRGH V D + + + LS S+DGT+++W
Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Query: 1017 NIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGC 1075
++ TG + FV H VLS S D + S S DKT K+W + + + H+
Sbjct: 91 DLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEW 150
Query: 1076 VRCSAFSVDST---LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFS 1132
V C FS +S+ +++ G D +++WN++N +L + H G++ + S
Sbjct: 151 VSCVRFSPNSSNPIIVSCGWDK-LVKVWNLANCKL--------KTNHIGHTGYLNTVTVS 201
Query: 1133 PDGKMLISAG--GYIKWWNVVTGESSQT 1158
PDG + S G G W++ G+ T
Sbjct: 202 PDGSLCASGGKDGQAMLWDLNEGKHLYT 229
Score = 68.2 bits (165), Expect = 5e-11
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 18/256 (7%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSD 969
VS +S Q+ G +G + + +L + H K V + F++D + ++S S
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSR 125
Query: 970 DAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSR---LLSWSFDGTVKVWNIITGNK 1023
D I++WN L C + H E V R NS ++S +D VKVWN+
Sbjct: 126 DKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKL 184
Query: 1024 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1083
+ + + H G + + +S D + +S D A +W + L+ L G + FS
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
Query: 1084 DSTLL--ATGDDNGEIRIWNVSNGELL--HLCAPLSEEGAATHGGWVTDLCFSPDGKMLI 1139
+ L ATG I+IW++ G+++ L + + T L +S DG+ L
Sbjct: 244 NRYWLCAATGP---SIKIWDL-EGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLF 299
Query: 1140 S--AGGYIKWWNVVTG 1153
+ ++ W V G
Sbjct: 300 AGYTDNLVRVWQVTIG 315
Score = 45.1 bits (105), Expect = 4e-04
Identities = 39/144 (27%), Positives = 59/144 (40%), Gaps = 10/144 (6%)
Query: 721 QKECRNTMFGHTNSVNHCRFSPD-DKLLASCSADGTLKLWDATSANERKSINVKQFFLNL 779
Q R T+ GH V +P ++ S S D T+ +W T + + + Q L
Sbjct: 4 QMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLT--RDETNYGIPQRALRG 61
Query: 780 EDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSP 838
VI S+DG + + + LW+ + + GH V V FS
Sbjct: 62 HSHFVSDVVI------SSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS 115
Query: 839 DGSSFLTSSDDQTIRLWETKKVCK 862
D ++ S D+TI+LW T VCK
Sbjct: 116 DNRQIVSGSRDKTIKLWNTLGVCK 139
Score = 37.4 bits (85), Expect = 0.086
Identities = 29/117 (24%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 1069 LRGHNGCVRCSAFSV---DSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
L+GHNG V A + D L A+ D I +W ++ E + + + H +
Sbjct: 11 LKGHNGWVTQIATTPQFPDMILSASRDKT--IIMWKLTRDETNY---GIPQRALRGHSHF 65
Query: 1126 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1180
V+D+ S DG+ +S G ++ W++ TG +++ F + ++ + S D + V+
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 100 bits (250), Expect = 6e-21
Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)
Query: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1005
H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 1006 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1065
S S D TV++W + F H TV S D F + S DKT K+W+
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189
Query: 1126 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1183
VT + F P G + +AG +K W+V T Q + + + + P +T +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 1184 LGILYILQTLE 1194
L IL +E
Sbjct: 250 DSTLKILDLME 260
Score = 100 bits (249), Expect = 8e-21
Identities = 78/340 (22%), Positives = 135/340 (39%), Gaps = 53/340 (15%)
Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
LLA+GS D +++W N K HT +V F D + + S D T+K+W
Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 821
+ + ++F +L V+C +S DG I+ A+ +K + LW+ SR V
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 822 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 881
H +V V F P G+ + D T+++W+ +
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR----------------------- 217
Query: 882 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 941
R Q L A V+ P Y+ + ++IL+L+ R+
Sbjct: 218 --------------THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL 263
Query: 942 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 981
+ H+ + F+ + S D ++ VW D
Sbjct: 264 LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 97.4 bits (241), Expect = 7e-20
Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS + +++AS D L V+ + + H+D V C FS +A
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
+ S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 840
+ G I A N + +W+ + + + H + V+G+ F P G
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 841 SSFLTSSDDQTIRL 854
+ +T+S D T+++
Sbjct: 242 NYLITASSDSTLKI 255
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 89.0 bits (219), Expect = 2e-17
Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS G +AS DKT++++ + +AH V F +D +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK VK+W + + + + +H V C F+ L+ + S D +KLWD + +
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
EC ++ H V + F P +A+ D T+K+WD R ++ + L+
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 228
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 833
V S+ G ++ A ++DS K+ D GH
Sbjct: 229 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 834 VMFSPDGSSFLTSSDDQTIRLWET 857
V FS G F + D+ + +W++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300
Score = 72.0 bits (175), Expect = 3e-12
Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 55/339 (16%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
GH ++V FS + K LAS S D L +W K + F +D
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V C ++S G + +++K + +W + + + R H + V V F DG SF+T+SD
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D+T+++W T + + L Q ++
Sbjct: 124 DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 146
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
V C SP + I ++ +++ + + S +H V ++ F + ++
Sbjct: 147 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 969 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1026
D ++VW+ + + + + H V + L++ S D T+K+ +++ G
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1063
HQG + S F+S +D+ +W +FD++
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305
Score = 71.6 bits (174), Expect = 4e-12
Identities = 71/333 (21%), Positives = 130/333 (39%), Gaps = 47/333 (14%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V C +S + ++ + + + +W+ +S+ GH V V FSP G + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D+T+R+W +K E VF+ + V +V + ++
Sbjct: 82 DKTVRIWVPN---------VKGE-STVFRAHTATVRSVH----------------FCSDG 115
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
Q ++ D+ +++ + S QH V +F+ D + ++S+S
Sbjct: 116 Q----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 969 DDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1025
DD +++W+ +C+ G T DF + + + D TVKVW++ T +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Query: 1026 DFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDS 1085
+ H V + S+D T KI L+ L GH G AFS
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 1086 TLLATGDDNGEIRIWN-----VSNGELLHLCAP 1113
A+G + ++ +W V +GE+ + P
Sbjct: 284 EYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
Score = 71.2 bits (173), Expect = 5e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 968
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 969 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1026
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1086
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 1087 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290
Score = 50.4 bits (119), Expect = 1e-05
Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)
Query: 1024 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1083
E+ F H+ V D S + + +S S D +W + GH V C FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 1084 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1117
LLA+G + +RIW + + +H C+ S++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 1118 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1163
+ H WV FSPDG++++SA +K W+ + E ++ +G
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 100 bits (250), Expect = 6e-21
Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 12/251 (4%)
Query: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL- 1005
H+ V + F+ + K L S S D+ + VW+ + + GH++ V + LL
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 1006 SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1065
S S D TV++W + F H TV S D F + S DKT K+W+
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
L L H VRC+ FS D L+ + D+ +++W+ S+ E +H HGG+
Sbjct: 138 LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--------SYCEHGGF 189
Query: 1126 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDN 1183
VT + F P G + +AG +K W+V T Q + + + + P +T +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 1184 LGILYILQTLE 1194
L IL +E
Sbjct: 250 DSTLKILDLME 260
Score = 100 bits (249), Expect = 8e-21
Identities = 78/340 (22%), Positives = 135/340 (39%), Gaps = 53/340 (15%)
Query: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
K H D V C FS + + +A+ S+D + +W+ + + H + V C +F+ S H
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH- 74
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
LLA+GS D +++W N K HT +V F D + + S D T+K+W
Sbjct: 75 -LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW--- 130
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 821
+ + ++F +L V+C +S DG I+ A+ +K + LW+ SR V
Sbjct: 131 ------ATHRQKFLFSLSQHIN----WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 180
Query: 822 ADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEV 881
H +V V F P G+ + D T+++W+ +
Sbjct: 181 HSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR----------------------- 217
Query: 882 MVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI 941
R Q L A V+ P Y+ + ++IL+L+ R+
Sbjct: 218 --------------THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL 263
Query: 942 FQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 981
+ H+ + F+ + S D ++ VW D
Sbjct: 264 LYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 97.4 bits (241), Expect = 7e-20
Identities = 70/254 (27%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS + +++AS D L V+ + + H+D V C FS +A
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLA 77
Query: 663 TCSVDKKVKIW-NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ 721
+ S DK V+IW ++ GE + H+ V HF + + T S D +K+W ++
Sbjct: 78 SGSRDKTVRIWVPNVKGEST-VFRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHR 134
Query: 722 KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 781
++ ++ H N V +FSPD +L+ S S D T+KLWD +S S F+ D
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDG 840
+ G I A N + +W+ + + + H + V+G+ F P G
Sbjct: 195 -------------FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSG 241
Query: 841 SSFLTSSDDQTIRL 854
+ +T+S D T+++
Sbjct: 242 NYLITASSDSTLKI 255
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 98 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 157
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 158 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 215
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 216 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 257
Score = 89.0 bits (219), Expect = 2e-17
Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS G +AS DKT++++ + +AH V F +D +
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK VK+W + + + + +H V C F+ L+ + S D +KLWD + +
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 177
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
EC ++ H V + F P +A+ D T+K+WD R ++ + L+
Sbjct: 178 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 228
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 833
V S+ G ++ A ++DS K+ D GH
Sbjct: 229 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 276
Query: 834 VMFSPDGSSFLTSSDDQTIRLWET 857
V FS G F + D+ + +W++
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS 300
Score = 72.0 bits (175), Expect = 3e-12
Identities = 70/339 (20%), Positives = 135/339 (39%), Gaps = 55/339 (16%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
GH ++V FS + K LAS S D L +W K + F +D
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVW------HMKPQSRAYRFTGHKDA------- 63
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V C ++S G + +++K + +W + + + R H + V V F DG SF+T+SD
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D+T+++W T + + L Q ++
Sbjct: 124 DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 146
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
V C SP + I ++ +++ + + S +H V ++ F + ++
Sbjct: 147 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 206
Query: 969 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1026
D ++VW+ + + + + H V + L++ S D T+K+ +++ G
Sbjct: 207 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 266
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1063
HQG + S F+S +D+ +W +FD++
Sbjct: 267 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 305
Score = 71.6 bits (174), Expect = 4e-12
Identities = 71/333 (21%), Positives = 130/333 (39%), Gaps = 47/333 (14%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V C +S + ++ + + + +W+ +S+ GH V V FSP G + S
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D+T+R+W +K E VF+ + V +V + ++
Sbjct: 82 DKTVRIWVPN---------VKGE-STVFRAHTATVRSVH----------------FCSDG 115
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
Q ++ D+ +++ + S QH V +F+ D + ++S+S
Sbjct: 116 Q----------SFVTASDDK-TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 969 DDAEIQVWNWQLDKCIFL---RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEK 1025
DD +++W+ +C+ G T DF + + + D TVKVW++ T +
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQ 223
Query: 1026 DFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDS 1085
+ H V + S+D T KI L+ L GH G AFS
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283
Query: 1086 TLLATGDDNGEIRIWN-----VSNGELLHLCAP 1113
A+G + ++ +W V +GE+ + P
Sbjct: 284 EYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRP 316
Score = 71.2 bits (173), Expect = 5e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 968
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 122
Query: 969 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1026
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 123 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 182
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1086
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 183 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 242
Query: 1087 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 290
Score = 50.4 bits (119), Expect = 1e-05
Identities = 40/176 (22%), Positives = 67/176 (38%), Gaps = 36/176 (20%)
Query: 1024 EKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSV 1083
E+ F H+ V D S + + +S S D +W + GH V C FS
Sbjct: 12 ERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP 71
Query: 1084 DSTLLATGDDNGEIRIW-------------NVSNGELLHLCA------PLSEE------- 1117
LLA+G + +RIW + + +H C+ S++
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 1118 --------GAATHGGWVTDLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNG 1163
+ H WV FSPDG++++SA +K W+ + E ++ +G
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHG 187
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 99.8 bits (247), Expect = 1e-20
Identities = 61/198 (30%), Positives = 101/198 (51%), Gaps = 13/198 (6%)
Query: 576 EVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAET 635
+VD+G+ ++ +NIT +S ++ HT ++ CF D QR+AS D+ ++++ +
Sbjct: 206 DVDHGICIMD---AENITTVS-VIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
Query: 636 GEKLLEI-KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGEL------VHTYDEHS 688
LL I KAH + + C F+ F+ T S DK +KIWN TGE V H
Sbjct: 262 QATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHE 321
Query: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
V+ CHF S L+ +G D + +WD+ + + ++ GH + V S + K +
Sbjct: 322 GSVSSCHFARDSSFLI--SGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL 379
Query: 749 SCSADGTLKLWDATSANE 766
S S D T++LW+ +E
Sbjct: 380 SASKDRTMRLWNIEEIDE 397
Score = 84.3 bits (207), Expect = 6e-16
Identities = 75/342 (21%), Positives = 148/342 (43%), Gaps = 58/342 (16%)
Query: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
GH ++V+ C F DD L S S D T+KLWD + + D + +
Sbjct: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSV------------VRDFEHRPKAP 147
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V CS + D +R++ A+ +K + W+ ++ + R + +++ FSPDG ++ D
Sbjct: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
++ + ++ ++I + +I D+ T +
Sbjct: 207 ----------------------------VDHGICIMDAENITTVSVIK------DHHTRS 232
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISS 967
++ CC P Q +A + I+I ++ + + + H + + FT L +S
Sbjct: 233 -ITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS 291
Query: 968 SDDAEIQVWNWQLDK------CIFL-RGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNII 1019
S D +++WN + C+ L +GH+ +V ++S L+S FD TV +W++
Sbjct: 292 SWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVA 351
Query: 1020 TGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFD 1061
G ++ H V+ IS++ S S D+T ++W+ +
Sbjct: 352 EGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
Score = 84.0 bits (206), Expect = 8e-16
Identities = 59/258 (22%), Positives = 120/258 (46%), Gaps = 14/258 (5%)
Query: 607 VYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIAT-CS 665
V + D R+ + DKT++ + ETG+ L +++ ++ ++ C FS D +++ +
Sbjct: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFD 206
Query: 666 VDKKVKIWNSMTGELVHTY-DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKEC 724
VD + I ++ V D H+ + C F S + A+ S D +K+WD+ +
Sbjct: 207 VDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRV--ASVSLDRCIKIWDVTSQAT 264
Query: 725 RNTMF-GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQ 783
T+ H+N++++C F+ L + S D LK+W+ + R
Sbjct: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLM------- 317
Query: 784 EDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
+ E V C ++ D + ++ ++ + +W+ + +GH WV V S +
Sbjct: 318 QGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKW 377
Query: 843 FLTSSDDQTIRLWETKKV 860
L++S D+T+RLW +++
Sbjct: 378 ILSASKDRTMRLWNIEEI 395
Score = 70.1 bits (170), Expect = 1e-11
Identities = 66/324 (20%), Positives = 135/324 (41%), Gaps = 25/324 (7%)
Query: 584 LEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 643
L W ++ ++ + ++ H AV F D ++ S D T++++ G + + +
Sbjct: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
Query: 644 AH-EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
+ V+ C+ + D + S DK V+ W+ TG+L+ + + C F+ +
Sbjct: 142 HRPKAPVVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKY 200
Query: 703 LLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
++ + N HT S+ C F PD + +AS S D +K+WD T
Sbjct: 201 VVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVT 260
Query: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKV 821
S +I + I CC ++ G + ++ +K + +WN + +
Sbjct: 261 SQATLLTIT-----------KAHSNAISNCC-FTFSGHFLCTSSWDKNLKIWNVHT-GEF 307
Query: 822 ADC-------RGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQE--V 872
+C +GH V F+ D S ++ D+T+ +W+ + + ++ + +
Sbjct: 308 RNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVM 367
Query: 873 DVVFQENEVMVLAVDHIRRLQLIN 896
DV N+ +L+ R ++L N
Sbjct: 368 DVAISNNKKWILSASKDRTMRLWN 391
Score = 60.5 bits (145), Expect = 9e-09
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 13/172 (7%)
Query: 986 LRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCH-QGTVLSCDISHDA 1043
L GH+ V + +++LLS S+D TVK+W+ + G+ +DF + V+ C I+ D+
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATG-DDNGEIRIWNV 1102
++ + S DKT + W + L ++R V C FS D + +G D + I I +
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCK-FSPDGKYVVSGFDVDHGICIMDA 216
Query: 1103 SNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKML--ISAGGYIKWWNVVT 1152
N + + H +T CF PD + + +S IK W+V +
Sbjct: 217 ENITTVSVIKD-------HHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS 261
Score = 59.3 bits (142), Expect = 2e-08
Identities = 74/337 (21%), Positives = 137/337 (40%), Gaps = 56/337 (16%)
Query: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETK--KVCKNSAVMLKQEV-DVVFQENEVM 882
GH V F D + L+ S D T++LW+ V ++ K V + +
Sbjct: 100 GHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSR 159
Query: 883 VLAVDHIRRLQLINGRTGQIDYLT--EAQVSCCCLSPHLQYIAFG-DENGAIEILELVN- 938
V+A + + ++ + TG++ + + + C SP +Y+ G D + I I++ N
Sbjct: 160 VIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMDAENI 219
Query: 939 NRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNW--QLDKCIFLRGHQETVKDF 996
+ + H +++ F D + + S S D I++W+ Q + H + +
Sbjct: 220 TTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNC 279
Query: 997 RLLKNSRLL-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTA 1055
+ L + S+D +K+WN+ TG +F + A T
Sbjct: 280 CFTFSGHFLCTSSWDKNLKIWNVHTG-----------------------EFRNCGACVTL 316
Query: 1056 KIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLS 1115
++GH G V F+ DS+ L +G + + IW+V+ G LS
Sbjct: 317 -------------MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEG-----YRKLS 358
Query: 1116 EEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNV 1150
+G H WV D+ S + K ++SA ++ WN+
Sbjct: 359 LKG---HNDWVMDVAISNNKKWILSASKDRTMRLWNI 392
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 97.4 bits (241), Expect = 7e-20
Identities = 75/286 (26%), Positives = 126/286 (44%), Gaps = 35/286 (12%)
Query: 603 HTDAVYHACFS---EDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
HT V FS G + S D + + +TG+ + H+ V + D
Sbjct: 13 HTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDAT 72
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
AT + D K+W++++G+ + T H V FT S++LL TG D L+++DL
Sbjct: 73 KAATAAADFTAKVWDAVSGDELMTL-AHKHIVKTVDFTQDSNYLL--TGGQDKLLRIYDL 129
Query: 720 NQKECR-NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
N+ E + GHT+ + + +DK + S D T++LWD + E KS+N +
Sbjct: 130 NKPEAEPKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATMTEVKSLNFNMSVSS 188
Query: 779 LE------------------------DPQEDMEVIVKCCSWSADGARIMVAAKN---KIF 811
+E DP + E S S + + A K++
Sbjct: 189 MEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLY 248
Query: 812 LWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 857
++ +S ++ +GH +H V FSPDG + + S+D T+RLW+T
Sbjct: 249 KYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQT 294
Score = 60.8 bits (146), Expect = 7e-09
Identities = 50/260 (19%), Positives = 109/260 (41%), Gaps = 19/260 (7%)
Query: 727 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 786
T GH +V + D A+ +AD T K+WDA S +E ++ K
Sbjct: 54 TFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKH------------ 101
Query: 787 EVIVKCCSWSADGARIMVAAKNKIF-LWNTDS-RSKVADCRGHLSWVHGVMFSPDGSSFL 844
IVK ++ D ++ ++K+ +++ + ++ + GH S + ++ + L
Sbjct: 102 --IVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQIL 159
Query: 845 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVV--FQENEVMVLAVDHIRRLQLINGRTGQI 902
S+DD+T+RLW+ + + ++ V + E E++V+
Sbjct: 160 -SADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIK 218
Query: 903 DYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEK 962
+ A ++ L P +++ G E+ + + + +S H + ++F+ D +
Sbjct: 219 SFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGE 278
Query: 963 TLISSSDDAEIQVWNWQLDK 982
S S+D +++W + K
Sbjct: 279 LYASGSEDGTLRLWQTVVGK 298
Score = 48.9 bits (115), Expect = 3e-05
Identities = 35/106 (33%), Positives = 55/106 (51%), Gaps = 7/106 (6%)
Query: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW---SF 1060
L+S DG + TG+ F+ H+G V ++ DATK ++ +AD TAK+W S
Sbjct: 32 LISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSG 91
Query: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1106
D L+ L H V+ F+ DS L TG + +RI++++ E
Sbjct: 92 DELMTL----AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPE 133
Score = 46.6 bits (109), Expect = 1e-04
Identities = 55/310 (17%), Positives = 109/310 (35%), Gaps = 49/310 (15%)
Query: 802 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 861
I K L D+ + GH V G + D + T++ D T ++W+
Sbjct: 33 ISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDA---- 88
Query: 862 KNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQY 921
+E+M LA HI + +D+ ++ Y
Sbjct: 89 --------------VSGDELMTLAHKHIVKT---------VDFTQDSN-----------Y 114
Query: 922 IAFGDENGAIEILELVNNRIFQSRFQH-----KKTVWHIQFTADEKTLISSSDDAEIQVW 976
+ G ++ + I +L KK +W E I S+DD +++W
Sbjct: 115 LLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALW-----CSEDKQILSADDKTVRLW 169
Query: 977 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1036
+ + +V + +L ++ ++ + ++ + K F T+ S
Sbjct: 170 DHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA-PATINS 228
Query: 1037 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1096
+ + + D + ++ L +GH G + C FS D L A+G ++G
Sbjct: 229 ASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGT 288
Query: 1097 IRIWNVSNGE 1106
+R+W G+
Sbjct: 289 LRLWQTVVGK 298
Score = 35.8 bits (81), Expect = 0.25
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 623 GADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGE 679
G D L + +GE+L K H + C FS D A+ S D +++W ++ G+
Sbjct: 242 GEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
Score = 35.0 bits (79), Expect = 0.43
Identities = 43/249 (17%), Positives = 91/249 (36%), Gaps = 14/249 (5%)
Query: 948 HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLS 1006
HK VW D +++ D +VW+ + H+ VK ++S LL+
Sbjct: 58 HKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLT 117
Query: 1007 WSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1066
D ++++++ E + + + + K ++ DKT ++W + +
Sbjct: 118 GGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEV 177
Query: 1067 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWV 1126
L S S++ GEI + H L + +
Sbjct: 178 KSLN-----FNMSVSSMEYI------PEGEILVITYGRSIAFHSAVSLDPIKSFEAPATI 226
Query: 1127 TDLCFSPDGKMLISAGGYIKW--WNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNL 1184
P+ + L++ G K ++ +GE +++ + + + SPD + Y +
Sbjct: 227 NSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSED 286
Query: 1185 GILYILQTL 1193
G L + QT+
Sbjct: 287 GTLRLWQTV 295
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 94.7 bits (234), Expect = 5e-19
Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 257 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 313
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 314 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 369
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 370 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 424
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 837
+ S DG ++ + I +W+ ++ + + GH S G+
Sbjct: 425 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 472
Query: 838 PDGSSFLTSSDDQTIRLWETK 858
+ ++ + D T+++W+ K
Sbjct: 473 --DNILVSGNADSTVKIWDIK 491
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 840 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 897
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 330
Query: 898 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 956
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 390
Query: 957 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1015
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 391 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 447
Query: 1016 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1072
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 448 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 505
Query: 1073 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1119
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 506 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 550
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 922 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 981
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 333
Query: 982 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1040
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 334 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 390
Query: 1041 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 391 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 448
Query: 1101 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1125
+V G +H +G H
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 508
Query: 1126 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1161
VT L F+ + + S G +K W++ TGE + T
Sbjct: 509 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 544
Score = 73.6 bits (179), Expect = 1e-12
Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V+ H AV C DG+R+ S D ++V+ ET L ++ H + V F D
Sbjct: 378 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 433
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ + S+D +++W+ TG +HT H + ++ +L +G++D +K+WD
Sbjct: 434 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 489
Query: 719 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ +C T+ G H ++V +F+ + + + S DGT+KLWD
Sbjct: 490 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 532
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 977 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1033
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 246 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 1034 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 306 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 361
Query: 1094 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1150
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 362 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 410
Query: 1151 VT 1152
T
Sbjct: 411 ET 412
Score = 58.2 bits (139), Expect = 5e-08
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT+ VY F DG + S D +++V+ ETG + + H+ L D +
Sbjct: 422 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 477
Query: 663 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
+ + D VKIW+ TG+ + T ++H V C F + + T S D +KLWDL
Sbjct: 478 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 533
Query: 720 NQKE 723
E
Sbjct: 534 KTGE 537
Score = 39.7 bits (91), Expect = 0.017
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 476 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 533
Query: 676 MTGELV 681
TGE +
Sbjct: 534 KTGEFI 539
Score = 32.3 bits (72), Expect = 2.8
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1069 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1127
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 258 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 309
Query: 1128 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1171
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 310 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 351
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 94.7 bits (234), Expect = 5e-19
Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 375 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 431
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 487
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 542
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 837
+ S DG ++ + I +W+ ++ + + GH S G+
Sbjct: 543 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 590
Query: 838 PDGSSFLTSSDDQTIRLWETK 858
+ ++ + D T+++W+ K
Sbjct: 591 --DNILVSGNADSTVKIWDIK 609
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 840 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 897
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 448
Query: 898 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 956
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 508
Query: 957 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1015
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 509 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 565
Query: 1016 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1072
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 566 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 623
Query: 1073 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1119
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 624 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 668
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 922 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 981
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 451
Query: 982 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1040
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 452 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 508
Query: 1041 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 509 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 566
Query: 1101 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1125
+V G +H +G H
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
Query: 1126 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1161
VT L F+ + + S G +K W++ TGE + T
Sbjct: 627 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 662
Score = 73.6 bits (179), Expect = 1e-12
Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V+ H AV C DG+R+ S D ++V+ ET L ++ H + V F D
Sbjct: 496 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 551
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ + S+D +++W+ TG +HT H + ++ +L +G++D +K+WD
Sbjct: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 607
Query: 719 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ +C T+ G H ++V +F+ + + + S DGT+KLWD
Sbjct: 608 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 650
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 977 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1033
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 364 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 1034 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 424 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 479
Query: 1094 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1150
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 480 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 528
Query: 1151 VT 1152
T
Sbjct: 529 ET 530
Score = 58.2 bits (139), Expect = 5e-08
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT+ VY F DG + S D +++V+ ETG + + H+ L D +
Sbjct: 540 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 595
Query: 663 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
+ + D VKIW+ TG+ + T ++H V C F + + T S D +KLWDL
Sbjct: 596 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 651
Query: 720 NQKE 723
E
Sbjct: 652 KTGE 655
Score = 39.7 bits (91), Expect = 0.017
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
Query: 676 MTGELV 681
TGE +
Sbjct: 652 KTGEFI 657
Score = 32.3 bits (72), Expect = 2.8
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1069 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1127
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 427
Query: 1128 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1171
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 428 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 94.7 bits (234), Expect = 5e-19
Identities = 67/261 (25%), Positives = 118/261 (45%), Gaps = 27/261 (10%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V++ H D V C G RI S D TL+V+ A TG+ L + H V D
Sbjct: 295 VLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--D 351
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
I + S D+ +K+WN+ TGE +HT H+ V C H H + +GS D L++WD
Sbjct: 352 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL----HEKRVVSGSRDATLRVWD 407
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
+ +C + + GH +V ++ D + + S + D +K+WD + ++ Q N
Sbjct: 408 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPET---ETCLHTLQGHTN 462
Query: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFS 837
+ S DG ++ + I +W+ ++ + + GH S G+
Sbjct: 463 ------------RVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 510
Query: 838 PDGSSFLTSSDDQTIRLWETK 858
+ ++ + D T+++W+ K
Sbjct: 511 --DNILVSGNADSTVKIWDIK 529
Score = 85.1 bits (209), Expect = 4e-16
Identities = 64/287 (22%), Positives = 125/287 (43%), Gaps = 16/287 (5%)
Query: 840 GSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLING 897
G+ ++ SDD T+++W T K + ++N ++ + D R L++ N
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTD--RTLKVWNA 368
Query: 898 RTGQIDYLTEAQVSCC-CLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQ 956
TG+ + S C+ H + + G + + + ++ + H V +Q
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ 428
Query: 957 FTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKV 1015
+ D + ++S + D ++VW+ + + C+ L+GH V + ++S S D +++V
Sbjct: 429 Y--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRV 485
Query: 1016 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRG---H 1072
W++ TGN HQ ++ + S +AD T KIW L L+G H
Sbjct: 486 WDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIKTGQCLQTLQGPNKH 543
Query: 1073 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1119
V C F+ + T D+G +++W++ GE + L G+
Sbjct: 544 QSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGS 588
Score = 80.9 bits (198), Expect = 7e-15
Identities = 67/276 (24%), Positives = 110/276 (39%), Gaps = 43/276 (15%)
Query: 922 IAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLD 981
I G ++ +++ V + ++ H VW Q + +IS S D ++VWN +
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETG 371
Query: 982 KCIF-LRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDIS 1040
+CI L GH TV+ L R++S S D T++VW+I TG + H V +
Sbjct: 372 ECIHTLYGHTSTVRCMHL-HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC--VQ 428
Query: 1041 HDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
+D + S + D K+W + LH L+GH R + D + +G + IR+W
Sbjct: 429 YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RVYSLQFDGIHVVSGSLDTSIRVW 486
Query: 1101 NVSNGELLHLCAPLSE-----------------------------------EGAATHGGW 1125
+V G +H +G H
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546
Query: 1126 VTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYT 1161
VT L F+ + + S G +K W++ TGE + T
Sbjct: 547 VTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVT 582
Score = 73.6 bits (179), Expect = 1e-12
Identities = 46/165 (27%), Positives = 83/165 (50%), Gaps = 13/165 (7%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V+ H AV C DG+R+ S D ++V+ ET L ++ H + V F D
Sbjct: 416 VLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DG 471
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
+ + S+D +++W+ TG +HT H + ++ +L +G++D +K+WD
Sbjct: 472 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN----ILVSGNADSTVKIWD 527
Query: 719 LNQKECRNTMFG---HTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ +C T+ G H ++V +F+ + + + S DGT+KLWD
Sbjct: 528 IKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWD 570
Score = 71.6 bits (174), Expect = 4e-12
Identities = 53/182 (29%), Positives = 85/182 (46%), Gaps = 21/182 (11%)
Query: 977 NW---QLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1033
NW +L L+GH + V +R++S S D T+KVW+ +TG + V H G
Sbjct: 284 NWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 1034 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1093
V S + + S S D+T K+W+ + +H L GH VRC + + +G
Sbjct: 344 VWSSQMRDNI--IISGSTDRTLKVWNAETGECIHTLYGHTSTVRC--MHLHEKRVVSGSR 399
Query: 1094 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGY---IKWWNV 1150
+ +R+W++ G+ LH+ L AA C DG+ ++S G Y +K W+
Sbjct: 400 DATLRVWDIETGQCLHV---LMGHVAAVR-------CVQYDGRRVVS-GAYDFMVKVWDP 448
Query: 1151 VT 1152
T
Sbjct: 449 ET 450
Score = 58.2 bits (139), Expect = 5e-08
Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 11/124 (8%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
HT+ VY F DG + S D +++V+ ETG + + H+ L D +
Sbjct: 460 HTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILV 515
Query: 663 TCSVDKKVKIWNSMTGELVHTY---DEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL 719
+ + D VKIW+ TG+ + T ++H V C F + + T S D +KLWDL
Sbjct: 516 SGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN----FVITSSDDGTVKLWDL 571
Query: 720 NQKE 723
E
Sbjct: 572 KTGE 575
Score = 39.7 bits (91), Expect = 0.017
Identities = 21/66 (31%), Positives = 37/66 (56%), Gaps = 5/66 (7%)
Query: 619 IASCGADKTLQVFKAETGEKLLEIKA---HEDEVLCCAFSTDDRFIATCSVDKKVKIWNS 675
+ S AD T++++ +TG+ L ++ H+ V C F+ + F+ T S D VK+W+
Sbjct: 514 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 571
Query: 676 MTGELV 681
TGE +
Sbjct: 572 KTGEFI 577
Score = 32.3 bits (72), Expect = 2.8
Identities = 24/106 (22%), Positives = 46/106 (43%), Gaps = 15/106 (14%)
Query: 1069 LRGHNG-CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVT 1127
L+GH+ + C F + +G D+ +++W+ G+ L T G W +
Sbjct: 296 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLV------GHTGGVWSS 347
Query: 1128 DLCFSPDGKMLISAGG--YIKWWNVVTGESSQTFYTNGTNLKKIHV 1171
+ ++IS +K WN TGE T Y + + ++ +H+
Sbjct: 348 QM----RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 389
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 90.1 bits (222), Expect = 1e-17
Identities = 54/162 (33%), Positives = 75/162 (46%), Gaps = 2/162 (1%)
Query: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
V R HT V F DGQ + DKT++V+ + L + H + V C FS D
Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
R I + S DK VK+W+ + E VH+Y EH V F S +A D +K+WD
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSG--TCIAAAGMDNTVKVWD 177
Query: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
+ H+ +VN F P L + S+D TLK+ D
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILD 219
Score = 89.7 bits (221), Expect = 1e-17
Identities = 63/229 (27%), Positives = 100/229 (43%), Gaps = 12/229 (5%)
Query: 970 DAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKDF 1027
D+ + VW+ + + GH++ V + LL S S D TV++W + F
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 1028 VCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTL 1087
H TV S D F + S DKT K+W+ L L H VRC+ FS D L
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 1088 LATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYI 1145
+ + D+ +++W+ S+ E +H HGG+VT + F P G + +AG +
Sbjct: 122 IVSASDDKTVKLWDKSSRECVH--------SYCEHGGFVTYVDFHPSGTCIAAAGMDNTV 173
Query: 1146 KWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1194
K W+V T Q + + + + P +T + L IL +E
Sbjct: 174 KVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLME 222
Score = 89.0 bits (219), Expect = 2e-17
Identities = 66/264 (25%), Positives = 110/264 (41%), Gaps = 32/264 (12%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H DAV FS G +AS DKT++++ + +AH V F +D +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S DK VK+W + + + + +H V C F+ L+ + S D +KLWD + +
Sbjct: 82 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR--LIVSASDDKTVKLWDKSSR 139
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 782
EC ++ H V + F P +A+ D T+K+WD R ++ + L+
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV-----RTHRLLQHYQLH---- 190
Query: 783 QEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTDSRSKVAD---------CRGHLSWVHG 833
V S+ G ++ A ++DS K+ D GH
Sbjct: 191 ----SAAVNGLSFHPSGNYLITA--------SSDSTLKILDLMEGRLLYTLHGHQGPATT 238
Query: 834 VMFSPDGSSFLTSSDDQTIRLWET 857
V FS G F + D+ + +W++
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVWKS 262
Score = 87.0 bits (214), Expect = 9e-17
Identities = 62/232 (26%), Positives = 105/232 (45%), Gaps = 18/232 (7%)
Query: 625 DKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIW-NSMTGELVHT 683
D L V+ + + H+D V C FS +A+ S DK V+IW ++ GE
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-V 60
Query: 684 YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPD 743
+ H+ V HF + + T S D +K+W ++++ ++ H N V +FSPD
Sbjct: 61 FRAHTATVRSVHFCSDGQSFV--TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPD 118
Query: 744 DKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
+L+ S S D T+KLWD +S S F+ D + G I
Sbjct: 119 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD-------------FHPSGTCIA 165
Query: 804 VAA-KNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRL 854
A N + +W+ + + + H + V+G+ F P G+ +T+S D T+++
Sbjct: 166 AAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 84.0 bits (206), Expect = 8e-16
Identities = 69/317 (21%), Positives = 122/317 (38%), Gaps = 53/317 (16%)
Query: 666 VDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECR 725
+D + +W+ + + H + V C +F+ S H LLA+GS D +++W N K
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGES 58
Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
HT +V F D + + S D T+K+W + + ++F +L
Sbjct: 59 TVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW---------ATHRQKFLFSLSQHIN- 108
Query: 786 MEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFL 844
V+C +S DG I+ A+ +K + LW+ SR V H +V V F P G+
Sbjct: 109 ---WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIA 165
Query: 845 TSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDY 904
+ D T+++W+ + R Q
Sbjct: 166 AAGMDNTVKVWDVR-------------------------------------THRLLQHYQ 188
Query: 905 LTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTL 964
L A V+ P Y+ + ++IL+L+ R+ + H+ + F+ +
Sbjct: 189 LHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYF 248
Query: 965 ISSSDDAEIQVWNWQLD 981
S D ++ VW D
Sbjct: 249 ASGGSDEQVMVWKSNFD 265
Score = 71.2 bits (173), Expect = 5e-12
Identities = 60/236 (25%), Positives = 100/236 (42%), Gaps = 12/236 (5%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLISSS 968
V+C SP +A G + + I + N + + F+ H TV + F +D ++ +++S
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTAS 84
Query: 969 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNIITGNKEKD 1026
DD ++VW K +F L H V+ + + RL+ S S D TVK+W+ +
Sbjct: 85 DDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHS 144
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST 1086
+ H G V D T ++ D T K+W L + H+ V +F
Sbjct: 145 YCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGN 204
Query: 1087 LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142
L T + ++I ++ G LL+ H G T + FS G+ S G
Sbjct: 205 YLITASSDSTLKILDLMEGRLLYT--------LHGHQGPATTVAFSRTGEYFASGG 252
Score = 70.9 bits (172), Expect = 7e-12
Identities = 68/312 (21%), Positives = 121/312 (38%), Gaps = 46/312 (14%)
Query: 810 IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLK 869
+ +W+ +S+ GH V V FSP G + S D+T+R+W +K
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN---------VK 55
Query: 870 QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENG 929
E VF+ + V +V + ++ Q ++ D+
Sbjct: 56 GE-STVFRAHTATVRSVH----------------FCSDGQ----------SFVTASDDK- 87
Query: 930 AIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFL--- 986
+++ + S QH V +F+ D + ++S+SDD +++W+ +C+
Sbjct: 88 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 147
Query: 987 RGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKF 1046
G T DF + + + D TVKVW++ T + + H V
Sbjct: 148 HGGFVTYVDFHP-SGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYL 206
Query: 1047 SSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWN----- 1101
+ S+D T KI L+ L GH G AFS A+G + ++ +W
Sbjct: 207 ITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDI 266
Query: 1102 VSNGELLHLCAP 1113
V +GE+ + P
Sbjct: 267 VDHGEVTKVPRP 278
Score = 63.9 bits (154), Expect = 9e-10
Identities = 54/279 (19%), Positives = 113/279 (40%), Gaps = 42/279 (15%)
Query: 790 VKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSD 848
V C ++S G + +++K + +W + + + R H + V V F DG SF+T+SD
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85
Query: 849 DQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
D+T+++W T + + L Q ++
Sbjct: 86 DKTVKVWATHR--QKFLFSLSQHIN----------------------------------- 108
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
V C SP + I ++ +++ + + S +H V ++ F + ++
Sbjct: 109 WVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAG 168
Query: 969 DDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKD 1026
D ++VW+ + + + + H V + L++ S D T+K+ +++ G
Sbjct: 169 MDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 228
Query: 1027 FVCHQGTVLSCDISHDATKFSSTSADKTAKIW--SFDLL 1063
HQG + S F+S +D+ +W +FD++
Sbjct: 229 LHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIV 267
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 90.1 bits (222), Expect = 1e-17
Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)
Query: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
Query: 797 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 851
D + AA + LWN S K+ C G L+ FSP+GS F+T S
Sbjct: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
Query: 852 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 887
+ +W+ K C +S Q V Q + ++ +++
Sbjct: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
Query: 888 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 942
HI +L ++G A V C S Q + G + ++ + + I
Sbjct: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
Query: 943 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996
+ QH + V F + L + S D + +W + L+ R + +K F
Sbjct: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
Score = 89.4 bits (220), Expect = 2e-17
Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
Query: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
Query: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
Query: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 817
W + ++ F L + V C++S DG ++ + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
Query: 818 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
+ + H +V F+P+ T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 618 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 670
R+ASCG D ++++ L E+K H VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
Query: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
++++ T ++HT +H+ V C F ++ LLLATGS D + +W +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
Score = 59.3 bits (142), Expect = 2e-08
Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)
Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
+T+ H + VN C FS LLA+CS D T++L+ +++ F P +
Sbjct: 6 HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52
Query: 786 MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 843
V CC +S G + + + LWNT++ +A S V FSPD +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 844 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 903
+ + D T+ LW + + +
Sbjct: 113 ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
+ + ++ C SP+ + G G + + + R S H + F++ +
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 964 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1005
L S D ++++W ++L L GH V + ++L
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 1006 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1062
S S D +V V++ T N H V +C + + ++ S DKT IW FDL
Sbjct: 255 VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
Score = 58.2 bits (139), Expect = 5e-08
Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)
Query: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
H VH FSP G + S D T LW T EN M+ +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
Query: 887 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946
+ + + V C SP +A G +G + + + ++++
Sbjct: 93 EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
Query: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 998
++ F+ + ++ S ++ VW+ ++ +C+ H E D +
Sbjct: 137 VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
Query: 999 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1043
L+ RL S D VK+W + I G + K H VL+C SHD
Sbjct: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
S S DK+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 968
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
Query: 969 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1020
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
Query: 1021 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1067
+ EK H + CD S + +S D KIW SF +L
Sbjct: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
Query: 1068 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
Query: 1124 GWVTDLCFSPDGKMLISAGGYIKWWNV 1150
+VT F+P+ +L++ G K N+
Sbjct: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
Score = 48.5 bits (114), Expect = 4e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 1038 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1092
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
Query: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1150
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
Query: 1151 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
+ + + +L SP+ +VT + G L +
Sbjct: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
Score = 38.1 bits (87), Expect = 0.050
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1124
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
Query: 1125 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1174
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 90.1 bits (222), Expect = 1e-17
Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)
Query: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
Query: 797 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 851
D + AA + LWN S K+ C G L+ FSP+GS F+T S
Sbjct: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
Query: 852 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 887
+ +W+ K C +S Q V Q + ++ +++
Sbjct: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
Query: 888 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 942
HI +L ++G A V C S Q + G + ++ + + I
Sbjct: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
Query: 943 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996
+ QH + V F + L + S D + +W + L+ R + +K F
Sbjct: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
Score = 89.4 bits (220), Expect = 2e-17
Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
Query: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
Query: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
Query: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 817
W + ++ F L + V C++S DG ++ + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
Query: 818 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
+ + H +V F+P+ T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 618 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 670
R+ASCG D ++++ L E+K H VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
Query: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
++++ T ++HT +H+ V C F ++ LLLATGS D + +W +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
Score = 59.3 bits (142), Expect = 2e-08
Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)
Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
+T+ H + VN C FS LLA+CS D T++L+ +++ F P +
Sbjct: 6 HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52
Query: 786 MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 843
V CC +S G + + + LWNT++ +A S V FSPD +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 844 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 903
+ + D T+ LW + + +
Sbjct: 113 ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
+ + ++ C SP+ + G G + + + R S H + F++ +
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 964 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1005
L S D ++++W ++L L GH V + ++L
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 1006 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1062
S S D +V V++ T N H V +C + + ++ S DKT IW FDL
Sbjct: 255 VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
Score = 58.2 bits (139), Expect = 5e-08
Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)
Query: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
H VH FSP G + S D T LW T EN M+ +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
Query: 887 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946
+ + + V C SP +A G +G + + + ++++
Sbjct: 93 EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
Query: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 998
++ F+ + ++ S ++ VW+ ++ +C+ H E D +
Sbjct: 137 VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
Query: 999 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1043
L+ RL S D VK+W + I G + K H VL+C SHD
Sbjct: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
S S DK+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 968
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
Query: 969 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1020
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
Query: 1021 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1067
+ EK H + CD S + +S D KIW SF +L
Sbjct: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
Query: 1068 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
Query: 1124 GWVTDLCFSPDGKMLISAGGYIKWWNV 1150
+VT F+P+ +L++ G K N+
Sbjct: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
Score = 48.5 bits (114), Expect = 4e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 1038 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1092
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
Query: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1150
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
Query: 1151 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
+ + + +L SP+ +VT + G L +
Sbjct: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
Score = 38.1 bits (87), Expect = 0.050
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1124
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
Query: 1125 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1174
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 90.1 bits (222), Expect = 1e-17
Identities = 90/354 (25%), Positives = 144/354 (40%), Gaps = 64/354 (18%)
Query: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQ--KECRNTMFGHTNSVN 736
+L+HT +H + VNCC F+ S LLAT S D ++L+ L + + + HT +V+
Sbjct: 3 KLIHTLADHGDDVNCCAFSFS----LLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVH 58
Query: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
C FSP +LASCS DGT LW+ + Q +E P V+ C +S
Sbjct: 59 CCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSP---VRVCQFS 106
Query: 797 ADGARIMV-AAKNKIFLWNTDSRSKVADC----RGHLSWVHGVMFSPDGSSFLTSSDDQT 851
D + AA + LWN S K+ C G L+ FSP+GS F+T S
Sbjct: 107 PDSTCLASGAADGTVVLWNAQS-YKLYRCGSVKDGSLA---ACAFSPNGSFFVTGSSCGD 162
Query: 852 IRLWETKKVCKNS----------AVMLKQEVDVVFQ--------------ENEVMVLAVD 887
+ +W+ K C +S Q V Q + ++ +++
Sbjct: 163 LTVWDDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFT 222
Query: 888 HIRRLQL-----INGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIF 942
HI +L ++G A V C S Q + G + ++ + + I
Sbjct: 223 HILGFELKYKSTLSGHC--------APVLACAFSHDGQMLVSGSVDKSVIVYDTNTENIL 274
Query: 943 QSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996
+ QH + V F + L + S D + +W + L+ R + +K F
Sbjct: 275 HTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQF 328
Score = 89.4 bits (220), Expect = 2e-17
Identities = 69/279 (24%), Positives = 122/279 (43%), Gaps = 21/279 (7%)
Query: 590 KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHE-DE 648
++ T L ++ HT AV+ CFS G +ASC D T ++ E G+ L ++
Sbjct: 40 RDFTELPHSPLKFHTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSP 99
Query: 649 VLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708
V C FS D +A+ + D V +WN+ + +L + C F S + TG
Sbjct: 100 VRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGSVKDGSLAACAF--SPNGSFFVTG 157
Query: 709 SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDK----------LLASCSADGTLKL 758
SS L +WD ++ C ++ H + C FS LASC D +K+
Sbjct: 158 SSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKI 216
Query: 759 WDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDS 817
W + ++ F L + V C++S DG ++ + +K + +++T++
Sbjct: 217 WIVSFT------HILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNT 270
Query: 818 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 856
+ + H +V F+P+ T S D+T+ +W+
Sbjct: 271 ENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ 309
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/110 (34%), Positives = 60/110 (54%), Gaps = 9/110 (8%)
Query: 618 RIASCGADKTLQVFKAETGEKL-LEIK------AHEDEVLCCAFSTDDRFIATCSVDKKV 670
R+ASCG D ++++ L E+K H VL CAFS D + + + SVDK V
Sbjct: 204 RLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSV 263
Query: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
++++ T ++HT +H+ V C F ++ LLLATGS D + +W +
Sbjct: 264 IVYDTNTENILHTLTQHTRYVTTCAFAPNT--LLLATGSMDKTVNIWQFD 311
Score = 59.3 bits (142), Expect = 2e-08
Identities = 75/358 (20%), Positives = 130/358 (36%), Gaps = 72/358 (20%)
Query: 726 NTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQED 785
+T+ H + VN C FS LLA+CS D T++L+ +++ F P +
Sbjct: 6 HTLADHGDDVNCCAFS--FSLLATCSLDKTIRLY-----------SLRDFTELPHSPLKF 52
Query: 786 MEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHL-SWVHGVMFSPDGSSF 843
V CC +S G + + + LWNT++ +A S V FSPD +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCL 112
Query: 844 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 903
+ + D T+ LW + + +
Sbjct: 113 ASGAADGTVVLWNAQSY-------------------------------------KLYRCG 135
Query: 904 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963
+ + ++ C SP+ + G G + + + R S H + F++ +
Sbjct: 136 SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWD-DKMRCLHSEKAHDLGITCCDFSSQPVS 194
Query: 964 ----------LISSSDDAEIQVW--------NWQLDKCIFLRGHQETVKDFRLLKNSRLL 1005
L S D ++++W ++L L GH V + ++L
Sbjct: 195 DGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDGQML 254
Query: 1006 -SWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDL 1062
S S D +V V++ T N H V +C + + ++ S DKT IW FDL
Sbjct: 255 VSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDL 312
Score = 58.2 bits (139), Expect = 5e-08
Identities = 67/297 (22%), Positives = 110/297 (37%), Gaps = 64/297 (21%)
Query: 827 HLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
H VH FSP G + S D T LW T EN M+ +
Sbjct: 53 HTYAVHCCCFSPSGHILASCSTDGTTVLWNT--------------------ENGQMLAVM 92
Query: 887 DHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 946
+ + + V C SP +A G +G + + + ++++
Sbjct: 93 EQP----------------SGSPVRVCQFSPDSTCLASGAADGTVVLWNAQSYKLYRCGS 136
Query: 947 QHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL-------- 998
++ F+ + ++ S ++ VW+ ++ +C+ H E D +
Sbjct: 137 VKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKM-RCL----HSEKAHDLGITCCDFSSQ 191
Query: 999 --------LKNSRLLSWSFDGTVKVWNI----ITGNKEK---DFVCHQGTVLSCDISHDA 1043
L+ RL S D VK+W + I G + K H VL+C SHD
Sbjct: 192 PVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFELKYKSTLSGHCAPVLACAFSHDG 251
Query: 1044 TKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIW 1100
S S DK+ ++ + LH L H V AF+ ++ LLATG + + IW
Sbjct: 252 QMLVSGSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
Score = 52.0 bits (123), Expect = 3e-06
Identities = 65/267 (24%), Positives = 105/267 (39%), Gaps = 42/267 (15%)
Query: 910 VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI-QFTADEKTLISSS 968
V CCC SP +A +G + N ++ Q + + QF+ D L S +
Sbjct: 57 VHCCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPDSTCLASGA 116
Query: 969 DDAEIQVWNWQLDKCIFLRGHQETVKDFRLL------KNSRLLSWSFDGTVKVWN--IIT 1020
D + +WN Q K ++ G +VKD L S ++ S G + VW+ +
Sbjct: 117 ADGTVVLWNAQSYK-LYRCG---SVKDGSLAACAFSPNGSFFVTGSSCGDLTVWDDKMRC 172
Query: 1021 GNKEKDFVCHQGTVLSCDISHDAT----------KFSSTSADKTAKIW--SFDLLLPLH- 1067
+ EK H + CD S + +S D KIW SF +L
Sbjct: 173 LHSEK---AHDLGITCCDFSSQPVSDGEQGLQFFRLASCGQDCQVKIWIVSFTHILGFEL 229
Query: 1068 ----ELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
L GH V AFS D +L +G + + +++ + +LH H
Sbjct: 230 KYKSTLSGHCAPVLACAFSHDGQMLVSGSVDKSVIVYDTNTENILHT--------LTQHT 281
Query: 1124 GWVTDLCFSPDGKMLISAGGYIKWWNV 1150
+VT F+P+ +L++ G K N+
Sbjct: 282 RYVTTCAFAPN-TLLLATGSMDKTVNI 307
Score = 48.5 bits (114), Expect = 4e-05
Identities = 45/159 (28%), Positives = 68/159 (42%), Gaps = 14/159 (8%)
Query: 1038 DISHDATKFS---STSADKTAKIWSFDLL--LPLHELRGHNGCVRCSAFSVDSTLLATGD 1092
D++ A FS + S DKT +++S LP L+ H V C FS +LA+
Sbjct: 14 DVNCCAFSFSLLATCSLDKTIRLYSLRDFTELPHSPLKFHTYAVHCCCFSPSGHILASCS 73
Query: 1093 DNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLIS--AGGYIKWWNV 1150
+G +WN NG++L + S G V FSPD L S A G + WN
Sbjct: 74 TDGTTVLWNTENGQMLAVMEQPS-------GSPVRVCQFSPDSTCLASGAADGTVVLWNA 126
Query: 1151 VTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
+ + + +L SP+ +VT + G L +
Sbjct: 127 QSYKLYRCGSVKDGSLAACAFSPNGSFFVTGSSCGDLTV 165
Score = 38.1 bits (87), Expect = 0.050
Identities = 36/113 (31%), Positives = 51/113 (45%), Gaps = 13/113 (11%)
Query: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN-GELLHLCAPLSEEGAATHGG 1124
+H L H V C AFS +LLAT + IR++++ + EL H +PL A H
Sbjct: 5 IHTLADHGDDVNCCAFSF--SLLATCSLDKTIRLYSLRDFTELPH--SPLKFHTYAVH-- 58
Query: 1125 WVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF-YTNGTNLKKIHVSPD 1174
CFSP G +L S G WN G+ +G+ ++ SPD
Sbjct: 59 ---CCCFSPSGHILASCSTDGTTVLWNTENGQMLAVMEQPSGSPVRVCQFSPD 108
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 89.7 bits (221), Expect = 1e-17
Identities = 51/164 (31%), Positives = 83/164 (50%), Gaps = 2/164 (1%)
Query: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
H V+ FS G S G D+ +++ + + L H +V C F + ++A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722
T S D+ V++W+ + G V + H ++ F+ + LATG++D + LWD+
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR--FLATGATDGRVLLWDIGHG 701
Query: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
+ GHT++V RFS D ++LAS S D T++LWDA A E
Sbjct: 702 LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFE 745
Score = 86.3 bits (212), Expect = 2e-16
Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 16/232 (6%)
Query: 629 QVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHS 688
++ +T +L + H V +FS D ++ + S D V++W+ T + Y H+
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHN 585
Query: 689 EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLA 748
V F+ ++ + +G D +LW + + GH VN RF P+ +A
Sbjct: 586 YPVWDTQFSPYGYYFV--SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643
Query: 749 SCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN 808
+ SAD T++LWD + N + F + P + ++S +G + A +
Sbjct: 644 TGSADRTVRLWDVLNGN------CVRIFTGHKGP-------IHSLTFSPNGRFLATGATD 690
Query: 809 -KIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 859
++ LW+ V + +GH V + FS DG + S D T+RLW+ K
Sbjct: 691 GRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 76.6 bits (187), Expect = 1e-13
Identities = 73/293 (24%), Positives = 128/293 (43%), Gaps = 48/293 (16%)
Query: 743 DDKLLASCSADGTLKLWDATSANERKSINVKQFF-LNLEDPQEDMEVIVKCCSWSADGAR 801
D L+A AD T+++W T +K +VKQ L+L D + D +V+ R
Sbjct: 481 DSSLIAGGFADSTVRVWSVTP---KKLRSVKQASDLSLIDKESD-DVL----------ER 526
Query: 802 IMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVC 861
IM + + S++ GH V+G FSPD + L+SS+D T+RLW +
Sbjct: 527 IM----------DEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT 576
Query: 862 -------KNSAVMLKQEVDVVF------QENEVMVLAVDHIRRLQLINGRTGQIDYLTEA 908
N V Q + + + A DH + L++ G A
Sbjct: 577 CLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL--------A 628
Query: 909 QVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSS 968
V+C P+ Y+A G + + + +++N + HK + + F+ + + L + +
Sbjct: 629 DVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGA 688
Query: 969 DDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL-SWSFDGTVKVWNII 1019
D + +W+ + L+GH +TV R ++ +L S S D TV++W+ I
Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/268 (23%), Positives = 112/268 (41%), Gaps = 14/268 (5%)
Query: 839 DGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE-VMVLAVDH--IRRLQLI 895
D S D T+R+W K +V ++ ++ +E++ V+ +D L+++
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPK-KLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539
Query: 896 NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 955
G +G V SP Y+ E+G + + L H VW
Sbjct: 540 YGHSGP--------VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDT 591
Query: 956 QFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRLLSW-SFDGTV 1013
QF+ +S D ++W + + GH V R NS ++ S D TV
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 1014 KVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHN 1073
++W+++ GN + F H+G + S S + ++ + D +W L + EL+GH
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHT 711
Query: 1074 GCVRCSAFSVDSTLLATGDDNGEIRIWN 1101
V FS D +LA+G + +R+W+
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 72.4 bits (176), Expect = 2e-12
Identities = 46/152 (30%), Positives = 71/152 (46%), Gaps = 10/152 (6%)
Query: 1004 LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLL 1063
LLS S DGTV++W++ T + H V S F S D+ A++W+ D
Sbjct: 558 LLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHY 617
Query: 1064 LPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHG 1123
PL GH V C+ F +S +ATG + +R+W+V NG + + H
Sbjct: 618 QPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI--------FTGHK 669
Query: 1124 GWVTDLCFSPDGKMLISAG--GYIKWWNVVTG 1153
G + L FSP+G+ L + G + W++ G
Sbjct: 670 GPIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Score = 66.6 bits (161), Expect = 1e-10
Identities = 72/322 (22%), Positives = 126/322 (39%), Gaps = 64/322 (19%)
Query: 657 DDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKL 716
D IA D V++W S+T + + + + S+ L+ S D ++
Sbjct: 481 DSSLIAGGFADSTVRVW-SVTPKKLRSVKQASDLS------------LIDKESDDVLERI 527
Query: 717 WDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
D ++GH+ V FSPD L S S DGT++LW + + K
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFT--CLVGYKGHN 585
Query: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVM 835
+ D Q +S G + +++ LW TD + GHL+ V+
Sbjct: 586 YPVWDTQ-----------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR 634
Query: 836 FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 895
F P+ + T S D+T+RLW+ V + V ++
Sbjct: 635 FHPNSNYVATGSADRTVRLWD---VLNGNCV--------------------------RIF 665
Query: 896 NGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHI 955
G G I LT SP+ +++A G +G + + ++ + + H TV +
Sbjct: 666 TGHKGPIHSLT--------FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL 717
Query: 956 QFTADEKTLISSSDDAEIQVWN 977
+F+ D + L S S D +++W+
Sbjct: 718 RFSRDGEILASGSMDNTVRLWD 739
Score = 36.6 bits (83), Expect = 0.15
Identities = 35/110 (31%), Positives = 49/110 (44%), Gaps = 20/110 (18%)
Query: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 659
++ HTD V FS DG+ +AS D T++++ A IKA ED TDD
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDA--------IKAFED------LETDDF 752
Query: 660 FIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS 709
AT ++ + G TY S V HFT +L+LA G+
Sbjct: 753 TTATGHINLPENSQELLLG----TYMTKSTPVVHLHFTR--RNLVLAAGA 796
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,177,362
Number of Sequences: 37866
Number of extensions: 2003692
Number of successful extensions: 10177
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 211
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 4918
Number of HSP's gapped (non-prelim): 2596
length of query: 1194
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1080
effective length of database: 13,930,794
effective search space: 15045257520
effective search space used: 15045257520
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.