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Search of human proteins with 44888833
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44888833 PDZ domain containing 6 [Homo sapiens]
(942 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44888833 PDZ domain containing 6 [Homo sapiens] 1897 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 41 0.005
gi|63999048 syntaxin binding protein 4 [Homo sapiens] 40 0.013
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 39 0.017
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 39 0.017
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 38 0.039
gi|33188449 serine/arginine-rich protein-specific kinase 2 isofo... 38 0.051
gi|33188447 serine/arginine-rich protein-specific kinase 2 isofo... 38 0.051
gi|157502184 kinesin family member 6 [Homo sapiens] 37 0.11
gi|87196343 PDZ domain containing 2 [Homo sapiens] 37 0.11
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 36 0.15
gi|27734775 hypothetical protein LOC286499 [Homo sapiens] 36 0.15
gi|112382257 InaD-like [Homo sapiens] 36 0.19
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 35 0.25
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 35 0.25
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 35 0.25
gi|56118310 nuclear casein kinase and cyclin-dependent kinase su... 35 0.25
gi|172072597 retinoblastoma-like 2 (p130) [Homo sapiens] 35 0.33
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 35 0.43
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 35 0.43
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 34 0.56
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 34 0.56
gi|211971072 FERM and PDZ domain containing 4 [Homo sapiens] 34 0.56
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 34 0.56
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 34 0.73
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 34 0.73
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 34 0.73
gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo s... 33 0.96
gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo sa... 33 0.96
gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo sa... 33 0.96
>gi|44888833 PDZ domain containing 6 [Homo sapiens]
Length = 942
Score = 1897 bits (4915), Expect = 0.0
Identities = 942/942 (100%), Positives = 942/942 (100%)
Query: 1 MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQ 60
MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQ
Sbjct: 1 MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQ 60
Query: 61 KNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRR 120
KNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRR
Sbjct: 61 KNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRR 120
Query: 121 KRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLK 180
KRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLK
Sbjct: 121 KRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLK 180
Query: 181 LLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT 240
LLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT
Sbjct: 181 LLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT 240
Query: 241 TENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQ 300
TENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQ
Sbjct: 241 TENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQ 300
Query: 301 SGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGT 360
SGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGT
Sbjct: 301 SGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGT 360
Query: 361 QVTSSSLLLNGKQIHVAYWKESDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDS 420
QVTSSSLLLNGKQIHVAYWKESDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDS
Sbjct: 361 QVTSSSLLLNGKQIHVAYWKESDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDS 420
Query: 421 AFCQIENVPRLDHFFNLFFQRALQPAKLHSSASPSAQQYDASSAVLLDNLPGVRWLTLPL 480
AFCQIENVPRLDHFFNLFFQRALQPAKLHSSASPSAQQYDASSAVLLDNLPGVRWLTLPL
Sbjct: 421 AFCQIENVPRLDHFFNLFFQRALQPAKLHSSASPSAQQYDASSAVLLDNLPGVRWLTLPL 480
Query: 481 EIKMELDMALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAV 540
EIKMELDMALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAV
Sbjct: 481 EIKMELDMALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAV 540
Query: 541 YCRHYCLLPLAAKQRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYM 600
YCRHYCLLPLAAKQRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYM
Sbjct: 541 YCRHYCLLPLAAKQRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYM 600
Query: 601 LCVLLEAGGCASKAIGSPGPDCVYVDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWF 660
LCVLLEAGGCASKAIGSPGPDCVYVDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWF
Sbjct: 601 LCVLLEAGGCASKAIGSPGPDCVYVDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWF 660
Query: 661 LTGSREKTDSLTTSPILSRLQGTSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGC 720
LTGSREKTDSLTTSPILSRLQGTSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGC
Sbjct: 661 LTGSREKTDSLTTSPILSRLQGTSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGC 720
Query: 721 EGGEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPE 780
EGGEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPE
Sbjct: 721 EGGEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPE 780
Query: 781 KELEIYNTVKLTSGPENTLFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCL 840
KELEIYNTVKLTSGPENTLFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCL
Sbjct: 781 KELEIYNTVKLTSGPENTLFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCL 840
Query: 841 SIRAVFQQTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVM 900
SIRAVFQQTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVM
Sbjct: 841 SIRAVFQQTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVM 900
Query: 901 AYWVVGRLFLHPKPQELYVCFHDSVTEIAIEIAFKLFFGLTL 942
AYWVVGRLFLHPKPQELYVCFHDSVTEIAIEIAFKLFFGLTL
Sbjct: 901 AYWVVGRLFLHPKPQELYVCFHDSVTEIAIEIAFKLFFGLTL 942
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 41.2 bits (95), Expect = 0.005
Identities = 17/46 (36%), Positives = 30/46 (65%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPG 253
+++ L+PGG A K G++L GD L+ VNDV++ ++E + + G
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKG 773
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/63 (26%), Positives = 36/63 (57%), Gaps = 6/63 (9%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVND---VDVTTENIERVL--SCIPGPMQVK 258
DG ++V ++ GG+ + G++ IGD ++++N+ + VT +L + GP +K
Sbjct: 1027 DGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGP-DIK 1085
Query: 259 LTF 261
+T+
Sbjct: 1086 ITY 1088
Score = 31.6 bits (70), Expect = 3.6
Identities = 14/54 (25%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI-PGPMQVKLT 260
+++H + G+A K G++ GD ++ VN +D+ + ++ + P +V+LT
Sbjct: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLT 1707
Score = 31.2 bits (69), Expect = 4.8
Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 6/107 (5%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI-PGPMQVKLTFE---- 262
+++ L G A G++ +GD ++AV+D V IE+ +S + M VKLT
Sbjct: 1506 VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENP 1565
Query: 263 NAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQ-SGLNTPHI 308
++ V +K S+ S +V E E I+ S +TP I
Sbjct: 1566 DSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAI 1612
Score = 30.8 bits (68), Expect = 6.2
Identities = 14/45 (31%), Positives = 26/45 (57%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERV 247
G ++V +LPGG A + G++ GD ++ + D D+ + E+V
Sbjct: 274 GKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQV 318
>gi|63999048 syntaxin binding protein 4 [Homo sapiens]
Length = 553
Score = 39.7 bits (91), Expect = 0.013
Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 9/129 (6%)
Query: 202 QGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTF 261
+ +G + + ++PGG K G++ GD LV+VN + + E S I G KL
Sbjct: 41 RNEGPLVYIQEIIPGGDCYKDGRLKPGDQLVSVNKESMIGVSFEEAKSIITG---AKLRL 97
Query: 262 ENAYDVK--RETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHIIMYLTLQLDSE 319
E+A+++ R+ S Q + S TS L+ G Q S L+ + + S
Sbjct: 98 ESAWEIAFIRQKSDNIQPENLSCTS----LIEASGEYGPQASTLSLFSSPPEILIPKTSS 153
Query: 320 TSKEEQEIL 328
T K +IL
Sbjct: 154 TPKTNNDIL 162
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/50 (38%), Positives = 30/50 (60%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQV 257
+ V ++PGG A K GQ+L GD L+ V+ V + ++ + C+ GP QV
Sbjct: 955 IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQV 1004
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/50 (38%), Positives = 30/50 (60%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQV 257
+ V ++PGG A K GQ+L GD L+ V+ V + ++ + C+ GP QV
Sbjct: 977 IYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQV 1026
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 38.1 bits (87), Expect = 0.039
Identities = 28/96 (29%), Positives = 51/96 (53%), Gaps = 12/96 (12%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI-----PGPMQV 257
G + V +LP G+A++ G++ GD L+ VN VD+ ++ E V+S + G + +
Sbjct: 483 GGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSL 542
Query: 258 KLTF--ENAYDVKRETSHPRQ----KKTQSNTSDLV 287
L F E+A+ + + P Q K+T++ D+V
Sbjct: 543 -LVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIV 577
>gi|33188449 serine/arginine-rich protein-specific kinase 2 isoform
a [Homo sapiens]
Length = 699
Score = 37.7 bits (86), Expect = 0.051
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 18 GDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQKNGEL----FYLELSED 73
G+ QEE ED + E+ D + +++P W++S + NG + F LE D
Sbjct: 354 GEAEDQEEKEDAEKENIEKDE---DDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLD 410
Query: 74 EEESLLPETPTVNHVRFSENEIIIEDDYKERKKYE 108
+E+ + P N ++ +E E DY YE
Sbjct: 411 DEDDDEEDCP--NPEEYNLDEPNAESDYTYSSSYE 443
>gi|33188447 serine/arginine-rich protein-specific kinase 2 isoform
b [Homo sapiens]
Length = 688
Score = 37.7 bits (86), Expect = 0.051
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 9/95 (9%)
Query: 18 GDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQKNGEL----FYLELSED 73
G+ QEE ED + E+ D + +++P W++S + NG + F LE D
Sbjct: 343 GEAEDQEEKEDAEKENIEKDE---DDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLD 399
Query: 74 EEESLLPETPTVNHVRFSENEIIIEDDYKERKKYE 108
+E+ + P N ++ +E E DY YE
Sbjct: 400 DEDDDEEDCP--NPEEYNLDEPNAESDYTYSSSYE 432
>gi|157502184 kinesin family member 6 [Homo sapiens]
Length = 814
Score = 36.6 bits (83), Expect = 0.11
Identities = 26/93 (27%), Positives = 43/93 (46%)
Query: 116 KILRRKRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKA 175
K+L K++L S D LK + +K I++QR ++N+ VN K KA
Sbjct: 430 KLLNDKKILENNTVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKA 489
Query: 176 KEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERL 208
+E L L + Q++ R G +G+R+
Sbjct: 490 QEALHLAGMDRREFRQSQSPPFRLGNPEEGQRM 522
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 36.6 bits (83), Expect = 0.11
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 16/104 (15%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDV---TTENIERVLS-CIPGPMQVKLTFEN 263
+ +H L PG A + GD ++ VN V+V + +LS C PGP+++ +
Sbjct: 755 IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVI---- 810
Query: 264 AYDVKRETSHPRQKKTQSNTSDLV-KLLWGEEVEGIQQSGLNTP 306
HP K ++ +++ + + E E GL TP
Sbjct: 811 -------GRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTP 847
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 36.2 bits (82), Expect = 0.15
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 4/75 (5%)
Query: 3 SVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSY-SSASSDYDDLEPEWLDSVQK 61
++ S D +E + +EE+E+ DFE+ D Y + ++ E E+ ++
Sbjct: 882 NINSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEF---EEE 938
Query: 62 NGELFYLELSEDEEE 76
GEL E EDEEE
Sbjct: 939 EGELEEEEEEEDEEE 953
>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
Length = 248
Score = 36.2 bits (82), Expect = 0.15
Identities = 32/143 (22%), Positives = 64/143 (44%), Gaps = 9/143 (6%)
Query: 3 SVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQK- 61
S S S SSD S++E++ + + SY S+ S + E E +SV+K
Sbjct: 101 SCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKK 160
Query: 62 -------NGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQF 114
E LS+ ++S P+ ++ SE++ + K++++ E + +
Sbjct: 161 KKSKDETEKEKDVRSLSKKRKKS-YPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAK 219
Query: 115 TKILRRKRLLPKRCNKKNSNDNG 137
K+ ++K+ K+ +KK +G
Sbjct: 220 EKVKKKKKKQHKKHSKKKKKKSG 242
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 35.8 bits (81), Expect = 0.19
Identities = 38/156 (24%), Positives = 73/156 (46%), Gaps = 19/156 (12%)
Query: 131 KNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLKLLEVLVGIIH 190
+NS+ ++ L+ Q+ QK ++V Y+D Y + + L + Q K L I
Sbjct: 1494 RNSSHEEAITALR-QTPQKVRLVV---YRDEAHYRDEENLEIFPVDLQKKAGRGLGLSI- 1548
Query: 191 QTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDV---TTENIERV 247
GK+ +G + + ++ GG+A G+++ GD +++VN D+ + E + +
Sbjct: 1549 --------VGKR-NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATI 1599
Query: 248 LSCIPGPMQVKL--TFENAYDVKRETSHPRQKKTQS 281
L C G +Q+++ ++ R TS Q QS
Sbjct: 1600 LKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQS 1635
Score = 34.7 bits (78), Expect = 0.43
Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 7/80 (8%)
Query: 200 GKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI-PGPMQVK 258
GK +V+H + G+A + G++ GD ++ VN VD+ + E ++ + P +V+
Sbjct: 1454 GKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVR 1513
Query: 259 LTFENAYDVKRETSHPRQKK 278
L V R+ +H R ++
Sbjct: 1514 LV------VYRDEAHYRDEE 1527
Score = 31.6 bits (70), Expect = 3.6
Identities = 12/41 (29%), Positives = 24/41 (58%)
Query: 199 TGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDV 239
T G+ + V ++PG +A +G + + D +VAV+ V++
Sbjct: 386 TSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNI 426
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 35.4 bits (80), Expect = 0.25
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ 256
DGE + V +L GG A SG++ GD +++VN +D+ + E+ + + G Q
Sbjct: 337 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 389
Score = 35.0 bits (79), Expect = 0.33
Identities = 13/38 (34%), Positives = 26/38 (68%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT 240
GD + + ++PGG+A + G++ + D ++ VN+VDV+
Sbjct: 71 GDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVS 108
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 35.4 bits (80), Expect = 0.25
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ 256
DGE + V +L GG A SG++ GD +++VN +D+ + E+ + + G Q
Sbjct: 545 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 597
Score = 35.0 bits (79), Expect = 0.33
Identities = 13/38 (34%), Positives = 26/38 (68%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT 240
GD + + ++PGG+A + G++ + D ++ VN+VDV+
Sbjct: 227 GDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVS 264
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 35.4 bits (80), Expect = 0.25
Identities = 18/53 (33%), Positives = 31/53 (58%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ 256
DGE + V +L GG A SG++ GD +++VN +D+ + E+ + + G Q
Sbjct: 440 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 492
Score = 35.0 bits (79), Expect = 0.33
Identities = 13/38 (34%), Positives = 26/38 (68%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVT 240
GD + + ++PGG+A + G++ + D ++ VN+VDV+
Sbjct: 122 GDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVS 159
>gi|56118310 nuclear casein kinase and cyclin-dependent kinase
substrate 1 [Homo sapiens]
Length = 243
Score = 35.4 bits (80), Expect = 0.25
Identities = 29/130 (22%), Positives = 55/130 (42%), Gaps = 13/130 (10%)
Query: 10 RPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEW---------LDSVQ 60
R + ++ +SQE+ ED + +D + SA D+ E +
Sbjct: 42 REAKNKRRSGKNSQEDSEDSEDKDVKTKKDDSHSAEDSEDEKEDHKNVRQQRQAASKAAS 101
Query: 61 KNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIED----DYKERKKYEPKLKQFTK 116
K E+ ++ +EE+ E P S+ + ++ED DY KK K+ + +K
Sbjct: 102 KQREMLMEDVGSEEEQEEEDEAPFQEKDSGSDEDFLMEDDDDSDYGSSKKKNKKMVKKSK 161
Query: 117 ILRRKRLLPK 126
R+++ +PK
Sbjct: 162 PERKEKKMPK 171
>gi|172072597 retinoblastoma-like 2 (p130) [Homo sapiens]
Length = 1139
Score = 35.0 bits (79), Expect = 0.33
Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 4/71 (5%)
Query: 723 GEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPEKE 782
G D S +P + K R S+ S + S + L V + S P P L D+ E+E
Sbjct: 942 GSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEE 1001
Query: 783 ----LEIYNTV 789
++ YN +
Sbjct: 1002 RGDLIQFYNNI 1012
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 34.7 bits (78), Expect = 0.43
Identities = 16/48 (33%), Positives = 29/48 (60%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI 251
DGE + + +L GG A SG++ GD +++VN VD+ + E+ + +
Sbjct: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Score = 32.7 bits (73), Expect = 1.6
Identities = 35/172 (20%), Positives = 74/172 (43%), Gaps = 24/172 (13%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFE 262
GD + + ++ GG+A + G++ + D ++ VN+VDV + + + +
Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL----------K 297
Query: 263 NAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQ-QSGLNTPHI----IMYLTLQLD 317
A + R + +++K S +KL+ G + G G+ HI +Y+T ++
Sbjct: 298 EAGSIVR--LYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIE 355
Query: 318 SETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLL 369
+ ++ ++ + KL +V + L E VT + TS + L
Sbjct: 356 GGAAHKDGKL-------QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYL 400
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 34.7 bits (78), Expect = 0.43
Identities = 16/48 (33%), Positives = 29/48 (60%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCI 251
DGE + + +L GG A SG++ GD +++VN VD+ + E+ + +
Sbjct: 485 DGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Score = 32.7 bits (73), Expect = 1.6
Identities = 35/172 (20%), Positives = 74/172 (43%), Gaps = 24/172 (13%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFE 262
GD + + ++ GG+A + G++ + D ++ VN+VDV + + + +
Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEAL----------K 297
Query: 263 NAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQ-QSGLNTPHI----IMYLTLQLD 317
A + R + +++K S +KL+ G + G G+ HI +Y+T ++
Sbjct: 298 EAGSIVR--LYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIE 355
Query: 318 SETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLL 369
+ ++ ++ + KL +V + L E VT + TS + L
Sbjct: 356 GGAAHKDGKL-------QIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYL 400
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 34.3 bits (77), Expect = 0.56
Identities = 13/37 (35%), Positives = 25/37 (67%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDV 239
GD + + ++PGG+A + G++ + D ++ VN+VDV
Sbjct: 132 GDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Score = 33.1 bits (74), Expect = 1.3
Identities = 16/43 (37%), Positives = 27/43 (62%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIER 246
DGE + + +L GG A SG++ GD +++VN VD+ + E+
Sbjct: 375 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQ 417
Score = 30.8 bits (68), Expect = 6.2
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 12/107 (11%)
Query: 161 VNVYVNPKKLTVIKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAM 220
V +YV +K K E +KL++ G+ GD + V ++ GG+A
Sbjct: 187 VRLYVMRRKPPAEKVME-IKLIKGPKGLGFSIAGGVGNQHIPGDNS-IYVTKIIEGGAAH 244
Query: 221 KSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDV 267
K G++ IGD ++AVN V + E ++ + +N YDV
Sbjct: 245 KDGRLQIGDKILAVNSVGLEDVMHEDAVAAL----------KNTYDV 281
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 34.3 bits (77), Expect = 0.56
Identities = 13/37 (35%), Positives = 25/37 (67%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDV 239
GD + + ++PGG+A + G++ + D ++ VN+VDV
Sbjct: 86 GDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Score = 33.1 bits (74), Expect = 1.3
Identities = 16/43 (37%), Positives = 27/43 (62%)
Query: 204 DGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIER 246
DGE + + +L GG A SG++ GD +++VN VD+ + E+
Sbjct: 329 DGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQ 371
Score = 30.8 bits (68), Expect = 6.2
Identities = 29/107 (27%), Positives = 48/107 (44%), Gaps = 12/107 (11%)
Query: 161 VNVYVNPKKLTVIKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAM 220
V +YV +K K E +KL++ G+ GD + V ++ GG+A
Sbjct: 141 VRLYVMRRKPPAEKVME-IKLIKGPKGLGFSIAGGVGNQHIPGDNS-IYVTKIIEGGAAH 198
Query: 221 KSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDV 267
K G++ IGD ++AVN V + E ++ + +N YDV
Sbjct: 199 KDGRLQIGDKILAVNSVGLEDVMHEDAVAAL----------KNTYDV 235
>gi|211971072 FERM and PDZ domain containing 4 [Homo sapiens]
Length = 1322
Score = 34.3 bits (77), Expect = 0.56
Identities = 27/94 (28%), Positives = 46/94 (48%), Gaps = 4/94 (4%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ-VKLTF 261
G + +VV + PGG + G+++ GD +V +ND V+ ERV+ + + + LT
Sbjct: 94 GSEKPVVVRSVTPGGPS--EGKLIPGDQIVMINDEPVSAAPRERVIDLVRSCKESILLTV 151
Query: 262 ENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEV 295
Y + KK + S+ VK+ + EEV
Sbjct: 152 IQPYPSPKSAFISAAKKARLK-SNPVKVRFSEEV 184
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b
[Homo sapiens]
Length = 1143
Score = 34.3 bits (77), Expect = 0.56
Identities = 24/92 (26%), Positives = 46/92 (50%), Gaps = 5/92 (5%)
Query: 208 LVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDV 267
+ V +LP G+A+K G++ GD ++ VN DVT E +++ + Q + + +
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETA---SLVI 466
Query: 268 KRETSH--PRQKKTQSNTSDLVKLLWGEEVEG 297
R+ H PR+ + +D + + GE + G
Sbjct: 467 ARQEGHFLPRELDGRLRMNDQLIAVNGESLLG 498
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform
2 [Homo sapiens]
Length = 1562
Score = 33.9 bits (76), Expect = 0.73
Identities = 23/57 (40%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 205 GERLV-VHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLT 260
G+R+V V + PGG+AMK+G V GD ++ VN VT + V+ I V LT
Sbjct: 63 GDRIVLVQSVRPGGAAMKAG-VKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALT 118
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform
1 [Homo sapiens]
Length = 1522
Score = 33.9 bits (76), Expect = 0.73
Identities = 23/57 (40%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 205 GERLV-VHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLT 260
G+R+V V + PGG+AMK+G V GD ++ VN VT + V+ I V LT
Sbjct: 63 GDRIVLVQSVRPGGAAMKAG-VKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALT 118
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 33.9 bits (76), Expect = 0.73
Identities = 41/168 (24%), Positives = 73/168 (43%), Gaps = 23/168 (13%)
Query: 262 ENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHIIMYLTLQLDSETS 321
E A + + E S Q K Q+N+ D VK L EE+E I+ I+YL QLD+ T
Sbjct: 157 EEAMNTQLELSE--QLKFQNNSEDNVKKLQ-EEIEKIRPG---FEEQILYLQKQLDATTD 210
Query: 322 KEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLLNGKQIHVAYWKE 381
++++ + + EA+ + +N+ Q LL K IH KE
Sbjct: 211 EKKETVTQLQNIIEANSQ------------HYQKNINSLQ----EELLQLKAIHQEEVKE 254
Query: 382 SDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDSAF-CQIENV 428
+ E + +L + EN+++ + ++ + C++EN+
Sbjct: 255 LMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENL 302
>gi|239757877 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1662
Score = 33.5 bits (75), Expect = 0.96
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ-VKLTF 261
G +VV + PGG + ++L GD +VA+N+ DV+ ER++ I + + LT
Sbjct: 37 GSERPVVVRSVRPGGPS--ENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTV 94
Query: 262 ENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEV 295
+ + + KK + S+ VK+ + E+V
Sbjct: 95 LHTHQSPKSAFISAAKKAKLR-SNPVKVRFSEQV 127
>gi|89060961 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1810
Score = 33.5 bits (75), Expect = 0.96
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ-VKLTF 261
G +VV + PGG + ++L GD +VA+N+ DV+ ER++ I + + LT
Sbjct: 70 GSERPVVVRSVRPGGPS--ENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTV 127
Query: 262 ENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEV 295
+ + + KK + S+ VK+ + E+V
Sbjct: 128 LHTHQSPKSAFISAAKKAKLR-SNPVKVRFSEQV 160
>gi|89059963 PREDICTED: FERM and PDZ domain containing 3 [Homo
sapiens]
Length = 1810
Score = 33.5 bits (75), Expect = 0.96
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 203 GDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQ-VKLTF 261
G +VV + PGG + ++L GD +VA+N+ DV+ ER++ I + + LT
Sbjct: 70 GSERPVVVRSVRPGGPS--ENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTV 127
Query: 262 ENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEV 295
+ + + KK + S+ VK+ + E+V
Sbjct: 128 LHTHQSPKSAFISAAKKAKLR-SNPVKVRFSEQV 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,431,520
Number of Sequences: 37866
Number of extensions: 1858499
Number of successful extensions: 6391
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 6212
Number of HSP's gapped (non-prelim): 253
length of query: 942
length of database: 18,247,518
effective HSP length: 112
effective length of query: 830
effective length of database: 14,006,526
effective search space: 11625416580
effective search space used: 11625416580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.